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Search of human proteins with 239741279
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo
sapiens]
(561 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens] 1099 0.0
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 377 e-104
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 375 e-104
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa... 374 e-103
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa... 374 e-103
gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member ... 370 e-102
gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member ... 370 e-102
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 273 2e-73
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 273 2e-73
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 273 2e-73
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 253 4e-67
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 253 4e-67
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 253 4e-67
gi|169178850 PREDICTED: similar to coiled-coil domain containing... 170 4e-42
gi|169217383 PREDICTED: similar to coiled-coil domain containing... 169 6e-42
gi|239750312 PREDICTED: similar to hCG1744891 [Homo sapiens] 168 1e-41
gi|239747109 PREDICTED: hypothetical protein XP_002344496 [Homo ... 168 1e-41
gi|239743762 PREDICTED: hypothetical protein XP_002342954 [Homo ... 165 1e-40
gi|149363632 coiled-coil domain containing 29 [Homo sapiens] 164 3e-40
gi|239742325 PREDICTED: similar to coiled-coil domain containing... 160 2e-39
gi|149363642 coiled-coil domain containing 144A [Homo sapiens] 151 2e-36
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 142 8e-34
gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH po... 129 5e-30
gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH po... 125 8e-29
gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens] 121 1e-27
gi|124517695 ankyrin repeat domain 36B [Homo sapiens] 121 1e-27
gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens] 116 6e-26
gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo... 116 6e-26
gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo... 116 6e-26
gi|169169660 PREDICTED: hypothetical protein [Homo sapiens] 100 6e-21
>gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens]
Length = 561
Score = 1099 bits (2843), Expect = 0.0
Identities = 561/561 (100%), Positives = 561/561 (100%)
Query: 1 MAQVAVSTLPIEDEESVEDEESLESRMVVTFLSALDSMVRPSVLTFYSSVGLGDVGISDE 60
MAQVAVSTLPIEDEESVEDEESLESRMVVTFLSALDSMVRPSVLTFYSSVGLGDVGISDE
Sbjct: 1 MAQVAVSTLPIEDEESVEDEESLESRMVVTFLSALDSMVRPSVLTFYSSVGLGDVGISDE 60
Query: 61 SAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGKGKGPPAK 120
SAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGKGKGPPAK
Sbjct: 61 SAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGKGKGPPAK 120
Query: 121 HPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNT 180
HPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNT
Sbjct: 121 HPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNT 180
Query: 181 NKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHDREELERKEKQYKK 240
NKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHDREELERKEKQYKK
Sbjct: 181 NKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHDREELERKEKQYKK 240
Query: 241 EVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMK 300
EVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMK
Sbjct: 241 EVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMK 300
Query: 301 EMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIE 360
EMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIE
Sbjct: 301 EMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIE 360
Query: 361 SGKKDLMLEEKNKKLMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKLTMLESP 420
SGKKDLMLEEKNKKLMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKLTMLESP
Sbjct: 361 SGKKDLMLEEKNKKLMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKLTMLESP 420
Query: 421 LEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMK 480
LEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMK
Sbjct: 421 LEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMK 480
Query: 481 KVQQECEKLEEDKKMLEEEILNLKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHL 540
KVQQECEKLEEDKKMLEEEILNLKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHL
Sbjct: 481 KVQQECEKLEEDKKMLEEEILNLKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHL 540
Query: 541 QEQAEHKKQLEQLNKDIIQLH 561
QEQAEHKKQLEQLNKDIIQLH
Sbjct: 541 QEQAEHKKQLEQLNKDIIQLH 561
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
sapiens]
Length = 823
Score = 377 bits (967), Expect = e-104
Identities = 239/529 (45%), Positives = 323/529 (61%), Gaps = 46/529 (8%)
Query: 54 DVGISDESAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGK 113
DVG SDESAVSI HEL VDSLP DD+DL+VATKQCVPEKVSEPL G SHEKGNRIVNG+
Sbjct: 265 DVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGNRIVNGQ 324
Query: 114 GKGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQ 173
G+GPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQ LPVA EEEQER ERSEKKQ Q
Sbjct: 325 GEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQ 384
Query: 174 VKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHD------ 227
VKEGNNTNKSEKIQLSEN+C STSSAAA RLT+QRK+GKTYPQQFPKKLK+EHD
Sbjct: 385 VKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQ 444
Query: 228 ---------------REELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSL 272
REELERKEKQYKKEVEAKQLEPTVQSL+MK KT RNTPN+
Sbjct: 445 ENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNR--DFH 502
Query: 273 RYSQKKVIGFRNS--PNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHE 330
+ + K + N D++ +Q+I MK +N E K N V+E L+
Sbjct: 503 NHEEMKGLMDENCILKADIAILRQEICTMKN--DNLE-KENKYLKDIKIVKETNAALEKY 559
Query: 331 NPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYE 390
E+ + + + +++ + +++ + L +E K+L + + + L
Sbjct: 560 IKLNEEMITETAFR--YQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAI 617
Query: 391 REKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDD 450
+ +E V R L+ +L++ + +E S DE + ++L + + +F+
Sbjct: 618 SKHSESVKTERNLKL----ALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFN- 672
Query: 451 FMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENS 510
A+ K K +++ L+++ VQ + + ++ + ++E N + + NS
Sbjct: 673 ------ALKDK---FRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNS 723
Query: 511 MVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKDIIQ 559
+ + ++E L V++L+++H +E +HK+ + + + I+
Sbjct: 724 TGKWNCVEERICHLQRENAWLVQQLDDVHQKE--DHKEIVTNIQRGFIE 770
Score = 212 bits (540), Expect = 6e-55
Identities = 127/259 (49%), Positives = 161/259 (62%), Gaps = 17/259 (6%)
Query: 155 VALEEEQ--ERCERSEKKQSQVKEGNNTNKSEKIQLSENV------CHSTSSAAADRLTK 206
+ L EE E R +++ + +K N +E ++ E+ S S A ++K
Sbjct: 560 IKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISK 619
Query: 207 QRKVGKTYPQQFPKKLKKEHDRE---ELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRN 263
+ KT + KL E R+ ++E K + E + L + +K ++
Sbjct: 620 HSESVKT---ERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD 676
Query: 264 TPNQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEER 323
+ SLR KK + NDLSQTQQQ +EMKEMY+NAEAKVNNSTGKW+CVEER
Sbjct: 677 KFRKTRDSLR---KKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEER 733
Query: 324 ICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLK 383
IC LQ EN + QQLDDVHQKEDHKEIVTNIQRGFIESGKKDL+LEEK+KKLMNECDHLK
Sbjct: 734 ICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLK 793
Query: 384 ESLFQYEREKAERVVVVRQ 402
ESLFQYEREK E VV +++
Sbjct: 794 ESLFQYEREKTEGVVSIKE 812
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
sapiens]
Length = 823
Score = 375 bits (964), Expect = e-104
Identities = 239/529 (45%), Positives = 322/529 (60%), Gaps = 46/529 (8%)
Query: 54 DVGISDESAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGK 113
DVG SDESAVSI HEL VDSLP DD+DL+VATKQCVPEKVSEPL G SHEKGNRIVNG+
Sbjct: 265 DVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGNRIVNGQ 324
Query: 114 GKGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQ 173
G+GPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQ LPVA EEEQER ERSEKKQ Q
Sbjct: 325 GEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQ 384
Query: 174 VKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHD------ 227
VKEGNNTNKSEKIQLSEN+C STSSAAA RLT+QRK+GKTYPQQFPKKLK+EHD
Sbjct: 385 VKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQ 444
Query: 228 ---------------REELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSL 272
REELERKEKQYKKEVEAKQLEPTVQSL+MK KT RNTPN+
Sbjct: 445 ENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNR--DFH 502
Query: 273 RYSQKKVIGFRNS--PNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHE 330
+ + K + N D++ +Q+I MK +N E K N V+E L+
Sbjct: 503 NHEEMKGLMDENCILKADIAILRQEICTMKN--DNLE-KENKYLKDIKIVKETNAALEKY 559
Query: 331 NPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYE 390
E+ + + + +++ + ++ + L +E K+L + + + L
Sbjct: 560 IKLNEEMITETAFR--YQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAI 617
Query: 391 REKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDD 450
+ +E V R L+ +L++ + +E S DE + ++L + + +F+
Sbjct: 618 SKHSESVKTERNLKL----ALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFN- 672
Query: 451 FMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENS 510
A+ K K +++ L+++ VQ + + ++ + ++E N + + NS
Sbjct: 673 ------ALKDK---FRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNS 723
Query: 511 MVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKDIIQ 559
+ + ++E L V++L+++H +E +HK+ + + + I+
Sbjct: 724 TGKWNCVEERICHLQRENAWLVQQLDDVHQKE--DHKEIVTNIQRGFIE 770
Score = 212 bits (540), Expect = 6e-55
Identities = 129/263 (49%), Positives = 160/263 (60%), Gaps = 19/263 (7%)
Query: 147 LRAEQTLPVALEEEQE----RCERSEKKQSQVKEGNNTNKSEKIQLSENVCHSTSSAAAD 202
L E A +QE + E + +KE K K +L ++ S S A
Sbjct: 562 LNEEMITETAFRYQQELNYLKAENTRLNAELLKE-----KESKKRLEADI-ESYQSRLAA 615
Query: 203 RLTKQRKVGKTYPQQFPKKLKKEHDRE---ELERKEKQYKKEVEAKQLEPTVQSLDMKLK 259
++K + KT + KL E R+ ++E K + E + L + +K
Sbjct: 616 AISKHSESVKT---ERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFN 672
Query: 260 TTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSC 319
++ + SLR KK + NDLSQTQQQ +EMKEMY+NAEAKVNNSTGKW+C
Sbjct: 673 ALKDKFRKTRDSLR---KKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNC 729
Query: 320 VEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNEC 379
VEERIC LQ EN + QQLDDVHQKEDHKEIVTNIQRGFIESGKKDL+LEEK+KKLMNEC
Sbjct: 730 VEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNEC 789
Query: 380 DHLKESLFQYEREKAERVVVVRQ 402
DHLKESLFQYEREK E VV +++
Sbjct: 790 DHLKESLFQYEREKTEGVVSIKE 812
>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
sapiens]
Length = 823
Score = 374 bits (960), Expect = e-103
Identities = 243/537 (45%), Positives = 321/537 (59%), Gaps = 62/537 (11%)
Query: 54 DVGISDESAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGK 113
DVG SDESAVSI HEL VDSLP DD+DL+VATKQCVPEKVSEPL G SHEKGNRIVNG+
Sbjct: 265 DVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGNRIVNGQ 324
Query: 114 GKGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQ 173
G+GPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQ LPVA EEEQER ERSEKKQ Q
Sbjct: 325 GEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQ 384
Query: 174 VKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHD------ 227
VKEGNNTNKSEKIQLSEN+C STSSAAA RLT+QRK+GKTYPQQFPKKLK+EHD
Sbjct: 385 VKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQ 444
Query: 228 ---------------REELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSL 272
REELERKEKQYKKEVEAKQLEPTVQSL+MK KT RNTPN
Sbjct: 445 ENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNW--DFH 502
Query: 273 RYSQKKVIGFRNS--PNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHE 330
+ + K + N D++ +Q+I MK +N E K N V+E L+
Sbjct: 503 NHEEMKGLMDENCILKADIAILRQEICTMKN--DNLE-KENKYLKDIKIVKETNAALEKY 559
Query: 331 NPCIEQQLDDV---HQKE--DHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKES 385
E+ + + +Q+E D K T + +L+ E+++KK L+
Sbjct: 560 IKLNEEMITETAFRYQQELNDLKAENTRL--------NAELLKEKESKK------RLEAD 605
Query: 386 LFQYEREKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVE 445
+ Y+ A + + ++S+K L+ LE + ++ + K + E
Sbjct: 606 IESYQSRLAAAI-------SKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKAENE 658
Query: 446 ---SQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILN 502
Q + + A+ K K +++ L+++ VQ + + ++ + ++E N
Sbjct: 659 FLTEQLSETQIKFNALKDK---FRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQN 715
Query: 503 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKDIIQ 559
+ + NS + + ++E L V++L+++H +E +HK+ + + + I+
Sbjct: 716 AEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKE--DHKEIVTNIQRGFIE 770
Score = 213 bits (543), Expect = 3e-55
Identities = 127/259 (49%), Positives = 161/259 (62%), Gaps = 17/259 (6%)
Query: 155 VALEEEQ--ERCERSEKKQSQVKEGNNTNKSEKIQLSENV------CHSTSSAAADRLTK 206
+ L EE E R +++ + +K N +E ++ E+ S S A ++K
Sbjct: 560 IKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISK 619
Query: 207 QRKVGKTYPQQFPKKLKKEHDRE---ELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRN 263
+ KT + KL E R+ ++E K + E + L + +K ++
Sbjct: 620 HSESVKT---ERNLKLALERTRDVSVQVEMSSAISKVKAENEFLTEQLSETQIKFNALKD 676
Query: 264 TPNQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEER 323
+ SLR KK + NDLSQTQQQ +EMKEMY+NAEAKVNNSTGKW+CVEER
Sbjct: 677 KFRKTRDSLR---KKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEER 733
Query: 324 ICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLK 383
IC LQ EN + QQLDDVHQKEDHKEIVTNIQRGFIESGKKDL+LEEK+KKLMNECDHLK
Sbjct: 734 ICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLK 793
Query: 384 ESLFQYEREKAERVVVVRQ 402
ESLFQYEREK E VV +++
Sbjct: 794 ESLFQYEREKTEGVVSIKE 812
>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
sapiens]
Length = 823
Score = 374 bits (959), Expect = e-103
Identities = 238/529 (44%), Positives = 321/529 (60%), Gaps = 46/529 (8%)
Query: 54 DVGISDESAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGK 113
DVG SDESAVSI HEL VDSLP DD+DL+VATKQCVPEKVSEPL G SHEKGNRIVNG+
Sbjct: 265 DVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGNRIVNGQ 324
Query: 114 GKGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQ 173
G+GPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQ LPVA EEEQ+R ERSEKKQ Q
Sbjct: 325 GEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQQRHERSEKKQPQ 384
Query: 174 VKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHD------ 227
VKEGNNTNKSEKIQLSEN+C STSSAAA RLT+QRK+GKTYPQQFPKKLK+EHD
Sbjct: 385 VKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQ 444
Query: 228 ---------------REELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSL 272
REELERKEKQYKKEVEAKQLEPTVQSL+MK KT RNTPN
Sbjct: 445 ENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNW--DFH 502
Query: 273 RYSQKKVIGFRNS--PNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHE 330
+ + K + N D++ +Q+I MK +N E K N V+E L+
Sbjct: 503 NHEEMKGLMDENCILKADIAILRQEICTMKN--DNLE-KENKYLKDIKIVKETNAALEKY 559
Query: 331 NPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYE 390
E+ + + + +++ + +++ + L +E K+L + + + L
Sbjct: 560 IKLNEEMITETAFR--YQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAI 617
Query: 391 REKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDD 450
+ +E V R L+ +L++ + +E S DE + ++L + + +F+
Sbjct: 618 SKHSESVKTERNLKL----ALERTQDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFN- 672
Query: 451 FMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENS 510
A+ K K +++ L+++ VQ + ++ + ++E N + + NS
Sbjct: 673 ------ALKDK---FRKTRDSLRKKSLALETVQNNLSQTQQQTQEMKEMYQNAEAKVNNS 723
Query: 511 MVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKDIIQ 559
+ + ++E L V++L+++H +E +HK+ + + + I+
Sbjct: 724 TGKWNCVEERICHLQRENAWLVQQLDDVHQKE--DHKEIVTNIQRGFIE 770
Score = 207 bits (527), Expect = 2e-53
Identities = 123/257 (47%), Positives = 159/257 (61%), Gaps = 13/257 (5%)
Query: 155 VALEEEQ--ERCERSEKKQSQVKEGNNTNKSEKIQLSENV------CHSTSSAAADRLTK 206
+ L EE E R +++ + +K N +E ++ E+ S S A ++K
Sbjct: 560 IKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISK 619
Query: 207 QRKVGKTYPQQFPKKLKKEHDRE-ELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTP 265
+ KT + L++ D ++E K + E + L + +K ++
Sbjct: 620 HSESVKT-ERNLKLALERTQDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKF 678
Query: 266 NQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERIC 325
+ SLR KK + N+LSQTQQQ +EMKEMY+NAEAKVNNSTGKW+CVEERIC
Sbjct: 679 RKTRDSLR---KKSLALETVQNNLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERIC 735
Query: 326 QLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKES 385
LQ EN + QQLDDVHQKEDHKEIVTNIQRGFIESGKKD +LEEK+KKLMNECDHLKES
Sbjct: 736 HLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDFVLEEKSKKLMNECDHLKES 795
Query: 386 LFQYEREKAERVVVVRQ 402
LFQYEREK E VV +++
Sbjct: 796 LFQYEREKTEVVVSIKE 812
>gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 370 bits (951), Expect = e-102
Identities = 242/511 (47%), Positives = 306/511 (59%), Gaps = 60/511 (11%)
Query: 54 DVGISDESAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGK 113
DVG SDESAVSI HELCVDSL LDDE LSVA KQCVPEKVSEPLRGPSH KGNRIVNGK
Sbjct: 265 DVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEKVSEPLRGPSHGKGNRIVNGK 324
Query: 114 GKGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQ 173
G+GPPAKHPSLKPSTE+EDPAVKGAVQ KNVQTLRAEQ LPVA EEEQ+R ERSEKKQ Q
Sbjct: 325 GEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQ 384
Query: 174 VKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHD------ 227
V EGNNT KSEKIQLSEN+CHST SAAADRLT+QRK+GKTYPQQFPKKLK+EHD
Sbjct: 385 VIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQ 444
Query: 228 ---------------REELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSL 272
REELERKEKQYKKEVEAKQLEPTVQSL+MK KT RNTPNQ
Sbjct: 445 ENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARNTPNQ--DFH 502
Query: 273 RYSQKKVIGFRNS--PNDLSQTQQQIKEMKE---MYENAEAKVNNSTGKWSCVEERICQL 327
+ + K + N D++ +Q+I MK EN K + + E+ +L
Sbjct: 503 NHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKL 562
Query: 328 QHENPC-----IEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHL 382
E +Q+L+D+ K ++ + + + L +E KKL E +
Sbjct: 563 NEEMITKTAFWYQQELNDL--KAENTRLNSEL-----------LKEKESKKKLEAEIESY 609
Query: 383 KESLFQYEREKAERVVVVRQLQ--QEAADSLKKLTMLESPLEGISHYHINLDETQVPKKK 440
+ L + +E V R L+ E + + + S + I + L E Q+ K +
Sbjct: 610 QSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTE-QLSKMQ 668
Query: 441 LFQVESQFDDFMAEKEAVSSKCVNL---AKEIQVFQQELLSMKKVQQECE----KLEEDK 493
+ + + D F ++ + K + L ++ QQ++ MK++ Q E K
Sbjct: 669 I-KFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKW 727
Query: 494 KMLEEEILNLKTH---MENSMVELSKLQEYK 521
+EE I L+ +E +V++ + +++K
Sbjct: 728 NCVEERICQLQRENPWLEQQLVDVHQKEDHK 758
Score = 213 bits (542), Expect = 4e-55
Identities = 126/263 (47%), Positives = 164/263 (62%), Gaps = 19/263 (7%)
Query: 147 LRAEQTLPVALEEEQE----RCERSEKKQSQVKEGNNTNKSE-KIQLSENVCHSTSSAAA 201
L E A +QE + E + +KE + K E +I+ ++ + S +
Sbjct: 562 LNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHS 621
Query: 202 DRLTKQR--KVGKTYPQQFPKKLKKEHDREELERKEKQYKKEVEAKQLEPTVQSLDMKLK 259
+ + +R K+ Q +++K D E+E K +++ Q++ +L K +
Sbjct: 622 ENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIK--FNTLKDKFR 679
Query: 260 TTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSC 319
TR+T +KK + NDLSQTQQQIKEMKEMY++AEAKV+ STGKW+C
Sbjct: 680 KTRDT----------LRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNC 729
Query: 320 VEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNEC 379
VEERICQLQ ENP +EQQL DVHQKEDHKEIV NIQRGFIES KKDLMLEEKNKKLMNE
Sbjct: 730 VEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEY 789
Query: 380 DHLKESLFQYEREKAERVVVVRQ 402
DHLKESLFQYER+KAE VV +++
Sbjct: 790 DHLKESLFQYERQKAETVVSIKE 812
>gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 370 bits (951), Expect = e-102
Identities = 242/511 (47%), Positives = 306/511 (59%), Gaps = 60/511 (11%)
Query: 54 DVGISDESAVSILHELCVDSLPTLDDEDLSVATKQCVPEKVSEPLRGPSHEKGNRIVNGK 113
DVG SDESAVSI HELCVDSL LDDE LSVA KQCVPEKVSEPLRGPSH KGNRIVNGK
Sbjct: 265 DVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQCVPEKVSEPLRGPSHGKGNRIVNGK 324
Query: 114 GKGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQ 173
G+GPPAKHPSLKPSTE+EDPAVKGAVQ KNVQTLRAEQ LPVA EEEQ+R ERSEKKQ Q
Sbjct: 325 GEGPPAKHPSLKPSTEMEDPAVKGAVQXKNVQTLRAEQALPVASEEEQQRRERSEKKQPQ 384
Query: 174 VKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHD------ 227
V EGNNT KSEKIQLSEN+CHST SAAADRLT+QRK+GKTYPQQFPKKLK+EHD
Sbjct: 385 VIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQ 444
Query: 228 ---------------REELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSL 272
REELERKEKQYKKEVEAKQLEPTVQSL+MK KT RNTPNQ
Sbjct: 445 ENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKPKTARNTPNQ--DFH 502
Query: 273 RYSQKKVIGFRNS--PNDLSQTQQQIKEMKE---MYENAEAKVNNSTGKWSCVEERICQL 327
+ + K + N D++ +Q+I MK EN K + + E+ +L
Sbjct: 503 NHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIKIAKETNAALEKCIKL 562
Query: 328 QHENPC-----IEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHL 382
E +Q+L+D+ K ++ + + + L +E KKL E +
Sbjct: 563 NEEMITKTAFWYQQELNDL--KAENTRLNSEL-----------LKEKESKKKLEAEIESY 609
Query: 383 KESLFQYEREKAERVVVVRQLQ--QEAADSLKKLTMLESPLEGISHYHINLDETQVPKKK 440
+ L + +E V R L+ E + + + S + I + L E Q+ K +
Sbjct: 610 QSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTE-QLSKMQ 668
Query: 441 LFQVESQFDDFMAEKEAVSSKCVNL---AKEIQVFQQELLSMKKVQQECE----KLEEDK 493
+ + + D F ++ + K + L ++ QQ++ MK++ Q E K
Sbjct: 669 I-KFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKW 727
Query: 494 KMLEEEILNLKTH---MENSMVELSKLQEYK 521
+EE I L+ +E +V++ + +++K
Sbjct: 728 NCVEERICQLQRENPWLEQQLVDVHQKEDHK 758
Score = 213 bits (542), Expect = 4e-55
Identities = 126/263 (47%), Positives = 164/263 (62%), Gaps = 19/263 (7%)
Query: 147 LRAEQTLPVALEEEQE----RCERSEKKQSQVKEGNNTNKSE-KIQLSENVCHSTSSAAA 201
L E A +QE + E + +KE + K E +I+ ++ + S +
Sbjct: 562 LNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHS 621
Query: 202 DRLTKQR--KVGKTYPQQFPKKLKKEHDREELERKEKQYKKEVEAKQLEPTVQSLDMKLK 259
+ + +R K+ Q +++K D E+E K +++ Q++ +L K +
Sbjct: 622 ENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIK--FNTLKDKFR 679
Query: 260 TTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSC 319
TR+T +KK + NDLSQTQQQIKEMKEMY++AEAKV+ STGKW+C
Sbjct: 680 KTRDT----------LRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNC 729
Query: 320 VEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNEC 379
VEERICQLQ ENP +EQQL DVHQKEDHKEIV NIQRGFIES KKDLMLEEKNKKLMNE
Sbjct: 730 VEERICQLQRENPWLEQQLVDVHQKEDHKEIVINIQRGFIESRKKDLMLEEKNKKLMNEY 789
Query: 380 DHLKESLFQYEREKAERVVVVRQ 402
DHLKESLFQYER+KAE VV +++
Sbjct: 790 DHLKESLFQYERQKAETVVSIKE 812
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 273 bits (699), Expect = 2e-73
Identities = 207/583 (35%), Positives = 275/583 (47%), Gaps = 171/583 (29%)
Query: 141 RKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNTNKSE---KIQLSENVCHSTS 197
+K + +AE L VA EE+QER ERSE KQ Q + K E L ++
Sbjct: 388 KKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKE 447
Query: 198 SAAA---DRLTKQRKVGK----------------------------TYPQQ--------- 217
A D L K++K + Y QQ
Sbjct: 448 ELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENA 507
Query: 218 -FPKKLKKE-HDREELERKEK-----------QYKKEVEAKQLEPTVQSLD--------- 255
KL+KE H++E LE + + +Y + +E K LE + D
Sbjct: 508 RLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRADDVSRHETMG 567
Query: 256 ---------------------MKLKTTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQ 294
+K T + + +LR +K + + DL Q Q
Sbjct: 568 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALR---EKTLALESVQLDLKQAQH 624
Query: 295 QIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNI 354
+IKEMK+M+ N EAK + S GK + EERI Q + EN +E+QL+D ++ D+KEIV NI
Sbjct: 625 RIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINI 684
Query: 355 QRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKL 414
R +E+GK+DL LEE+NK+LMNE ++LKE L QYE+EKAER V+VR+ Q+E D LKK
Sbjct: 685 HRDCLENGKEDL-LEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKF 743
Query: 415 TMLESPLEGISHYHINLDETQVPKKKLFQVESQ----FDDFMAEKEAVS----------- 459
+M ESPLEG SH HINLDET KKKLFQVE Q ++F E +S
Sbjct: 744 SMSESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRK 803
Query: 460 ------------SKCVNLA------------------------------KEIQVFQQELL 477
KC+ + K Q F +
Sbjct: 804 KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMA 863
Query: 478 SMKKVQQECEKLEEDKKML------------------------EEEILNLKTHMENSMVE 513
+ V +C L +D ++L EE++LNLKTHME MVE
Sbjct: 864 EKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVE 923
Query: 514 LSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKD 556
L K+QEYKSELDERAMQA+EKLEEIHLQ+QAE++KQLEQLNKD
Sbjct: 924 LGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKD 966
Score = 35.0 bits (79), Expect = 0.18
Identities = 67/335 (20%), Positives = 133/335 (39%), Gaps = 56/335 (16%)
Query: 234 KEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGFRN--------- 284
K+K ++ E++ ++ + + + T +QI + R +++ G++
Sbjct: 767 KKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINML 826
Query: 285 ---SPNDLS----QTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQ 337
+ D S Q+K M +++ + K ++ + V + L +N + Q+
Sbjct: 827 NAFANEDFSCHGDLNTDQLK-MDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQE 885
Query: 338 LDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQ------YER 391
L + + ++ E +E KK MLEEK ++N H+++ + + Y+
Sbjct: 886 LLSMGKVQEKCEK--------LEKDKK--MLEEK---VLNLKTHMEKDMVELGKVQEYKS 932
Query: 392 EKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDDF 451
E ER + + +E L+K E LE +N D T KKK ++ F
Sbjct: 933 ELDERAMQAIEKLEEI--HLQKQAEYEKQLE-----QLNKDNTASLKKKELTLKDVECKF 985
Query: 452 MAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENSM 511
K A L + + F L + + ++ K DKK+ +++ K ME
Sbjct: 986 SKMKTAYEDVTTELEEYKEAFAVALKANSSMSEKITK--SDKKI---AVISTKLFMEK-- 1038
Query: 512 VELSKLQEYKSELDER---AMQAVEKLEEIHLQEQ 543
+++ + S L R + VE L I L +
Sbjct: 1039 ---ERMEYFLSTLPMRPDPELPCVENLNSIELNRK 1070
Score = 32.3 bits (72), Expect = 1.2
Identities = 80/382 (20%), Positives = 160/382 (41%), Gaps = 62/382 (16%)
Query: 222 LKKEHDREELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIG 281
+K E+ ++ +RK+ + +KE + V S + + + R+ Q S Y +KK
Sbjct: 373 MKPENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEM 432
Query: 282 FRN----------------SPNDLSQTQ----QQIKEMKEMYENAEAKVNNS----TGKW 317
F N ND + + Q+IK + E+ N E V + T K
Sbjct: 433 FGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKV 492
Query: 318 SCVEERICQLQHENPCIEQQLD-DVHQKED--------HKEIVTNIQRGFIESGKKDLML 368
+ +++ L+ EN + +L+ + H KE H + T I +KDL L
Sbjct: 493 AQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLEL 552
Query: 369 ----------EEKNKKLMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKLTMLE 418
E +++ E L + + + ++ +E D+L++ T+
Sbjct: 553 VLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTL-- 610
Query: 419 SPLEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLS 478
+ ++L + Q K++ Q+ + KE+ S N ++E ++ Q+EL +
Sbjct: 611 ----ALESVQLDLKQAQHRIKEMKQMHPNGE----AKESQSIGKQNSSEE-RIRQRELEN 661
Query: 479 MKKVQQ-ECEKLEEDKKMLEEEILNL-KTHMENSMVELSKLQEYKSELDERAMQAVEKLE 536
+ +Q E + E D K E ++N+ + +EN +L L+E EL EKL
Sbjct: 662 LLLERQLEDARKEGDNK---EIVINIHRDCLENGKEDL--LEERNKELMNEYNYLKEKLL 716
Query: 537 EIHLQEQAEHKKQLEQLNKDII 558
+ + +E+AE + + + ++++
Sbjct: 717 Q-YEKEKAEREVIVREFQEELV 737
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 273 bits (699), Expect = 2e-73
Identities = 207/583 (35%), Positives = 275/583 (47%), Gaps = 171/583 (29%)
Query: 141 RKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNTNKSE---KIQLSENVCHSTS 197
+K + +AE L VA EE+QER ERSE KQ Q + K E L ++
Sbjct: 417 KKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKE 476
Query: 198 SAAA---DRLTKQRKVGK----------------------------TYPQQ--------- 217
A D L K++K + Y QQ
Sbjct: 477 ELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENA 536
Query: 218 -FPKKLKKE-HDREELERKEK-----------QYKKEVEAKQLEPTVQSLD--------- 255
KL+KE H++E LE + + +Y + +E K LE + D
Sbjct: 537 RLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRADDVSRHETMG 596
Query: 256 ---------------------MKLKTTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQ 294
+K T + + +LR +K + + DL Q Q
Sbjct: 597 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALR---EKTLALESVQLDLKQAQH 653
Query: 295 QIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNI 354
+IKEMK+M+ N EAK + S GK + EERI Q + EN +E+QL+D ++ D+KEIV NI
Sbjct: 654 RIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINI 713
Query: 355 QRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKL 414
R +E+GK+DL LEE+NK+LMNE ++LKE L QYE+EKAER V+VR+ Q+E D LKK
Sbjct: 714 HRDCLENGKEDL-LEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKF 772
Query: 415 TMLESPLEGISHYHINLDETQVPKKKLFQVESQ----FDDFMAEKEAVS----------- 459
+M ESPLEG SH HINLDET KKKLFQVE Q ++F E +S
Sbjct: 773 SMSESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRK 832
Query: 460 ------------SKCVNLA------------------------------KEIQVFQQELL 477
KC+ + K Q F +
Sbjct: 833 KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMA 892
Query: 478 SMKKVQQECEKLEEDKKML------------------------EEEILNLKTHMENSMVE 513
+ V +C L +D ++L EE++LNLKTHME MVE
Sbjct: 893 EKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVE 952
Query: 514 LSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKD 556
L K+QEYKSELDERAMQA+EKLEEIHLQ+QAE++KQLEQLNKD
Sbjct: 953 LGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKD 995
Score = 35.0 bits (79), Expect = 0.18
Identities = 67/335 (20%), Positives = 133/335 (39%), Gaps = 56/335 (16%)
Query: 234 KEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGFRN--------- 284
K+K ++ E++ ++ + + + T +QI + R +++ G++
Sbjct: 796 KKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINML 855
Query: 285 ---SPNDLS----QTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQ 337
+ D S Q+K M +++ + K ++ + V + L +N + Q+
Sbjct: 856 NAFANEDFSCHGDLNTDQLK-MDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQE 914
Query: 338 LDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQ------YER 391
L + + ++ E +E KK MLEEK ++N H+++ + + Y+
Sbjct: 915 LLSMGKVQEKCEK--------LEKDKK--MLEEK---VLNLKTHMEKDMVELGKVQEYKS 961
Query: 392 EKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDDF 451
E ER + + +E L+K E LE +N D T KKK ++ F
Sbjct: 962 ELDERAMQAIEKLEEI--HLQKQAEYEKQLE-----QLNKDNTASLKKKELTLKDVECKF 1014
Query: 452 MAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENSM 511
K A L + + F L + + ++ K DKK+ +++ K ME
Sbjct: 1015 SKMKTAYEDVTTELEEYKEAFAVALKANSSMSEKITK--SDKKI---AVISTKLFMEK-- 1067
Query: 512 VELSKLQEYKSELDER---AMQAVEKLEEIHLQEQ 543
+++ + S L R + VE L I L +
Sbjct: 1068 ---ERMEYFLSTLPMRPDPELPCVENLNSIELNRK 1099
Score = 32.3 bits (72), Expect = 1.2
Identities = 80/382 (20%), Positives = 160/382 (41%), Gaps = 62/382 (16%)
Query: 222 LKKEHDREELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIG 281
+K E+ ++ +RK+ + +KE + V S + + + R+ Q S Y +KK
Sbjct: 402 MKPENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEM 461
Query: 282 FRN----------------SPNDLSQTQ----QQIKEMKEMYENAEAKVNNS----TGKW 317
F N ND + + Q+IK + E+ N E V + T K
Sbjct: 462 FGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKV 521
Query: 318 SCVEERICQLQHENPCIEQQLD-DVHQKED--------HKEIVTNIQRGFIESGKKDLML 368
+ +++ L+ EN + +L+ + H KE H + T I +KDL L
Sbjct: 522 AQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLEL 581
Query: 369 ----------EEKNKKLMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKLTMLE 418
E +++ E L + + + ++ +E D+L++ T+
Sbjct: 582 VLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTL-- 639
Query: 419 SPLEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLS 478
+ ++L + Q K++ Q+ + KE+ S N ++E ++ Q+EL +
Sbjct: 640 ----ALESVQLDLKQAQHRIKEMKQMHPNGE----AKESQSIGKQNSSEE-RIRQRELEN 690
Query: 479 MKKVQQ-ECEKLEEDKKMLEEEILNL-KTHMENSMVELSKLQEYKSELDERAMQAVEKLE 536
+ +Q E + E D K E ++N+ + +EN +L L+E EL EKL
Sbjct: 691 LLLERQLEDARKEGDNK---EIVINIHRDCLENGKEDL--LEERNKELMNEYNYLKEKLL 745
Query: 537 EIHLQEQAEHKKQLEQLNKDII 558
+ + +E+AE + + + ++++
Sbjct: 746 Q-YEKEKAEREVIVREFQEELV 766
>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1139
Score = 273 bits (699), Expect = 2e-73
Identities = 207/583 (35%), Positives = 275/583 (47%), Gaps = 171/583 (29%)
Query: 141 RKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNTNKSE---KIQLSENVCHSTS 197
+K + +AE L VA EE+QER ERSE KQ Q + K E L ++
Sbjct: 417 KKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKE 476
Query: 198 SAAA---DRLTKQRKVGK----------------------------TYPQQ--------- 217
A D L K++K + Y QQ
Sbjct: 477 ELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENA 536
Query: 218 -FPKKLKKE-HDREELERKEK-----------QYKKEVEAKQLEPTVQSLD--------- 255
KL+KE H++E LE + + +Y + +E K LE + D
Sbjct: 537 RLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRADDVSRHETMG 596
Query: 256 ---------------------MKLKTTRNTPNQINQSLRYSQKKVIGFRNSPNDLSQTQQ 294
+K T + + +LR +K + + DL Q Q
Sbjct: 597 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALR---EKTLALESVQLDLKQAQH 653
Query: 295 QIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNI 354
+IKEMK+M+ N EAK + S GK + EERI Q + EN +E+QL+D ++ D+KEIV NI
Sbjct: 654 RIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINI 713
Query: 355 QRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKL 414
R +E+GK+DL LEE+NK+LMNE ++LKE L QYE+EKAER V+VR+ Q+E D LKK
Sbjct: 714 HRDCLENGKEDL-LEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKF 772
Query: 415 TMLESPLEGISHYHINLDETQVPKKKLFQVESQ----FDDFMAEKEAVS----------- 459
+M ESPLEG SH HINLDET KKKLFQVE Q ++F E +S
Sbjct: 773 SMSESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRK 832
Query: 460 ------------SKCVNLA------------------------------KEIQVFQQELL 477
KC+ + K Q F +
Sbjct: 833 KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMA 892
Query: 478 SMKKVQQECEKLEEDKKML------------------------EEEILNLKTHMENSMVE 513
+ V +C L +D ++L EE++LNLKTHME MVE
Sbjct: 893 EKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVE 952
Query: 514 LSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKD 556
L K+QEYKSELDERAMQA+EKLEEIHLQ+QAE++KQLEQLNKD
Sbjct: 953 LGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKD 995
Score = 35.0 bits (79), Expect = 0.18
Identities = 67/335 (20%), Positives = 133/335 (39%), Gaps = 56/335 (16%)
Query: 234 KEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGFRN--------- 284
K+K ++ E++ ++ + + + T +QI + R +++ G++
Sbjct: 796 KKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINML 855
Query: 285 ---SPNDLS----QTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQ 337
+ D S Q+K M +++ + K ++ + V + L +N + Q+
Sbjct: 856 NAFANEDFSCHGDLNTDQLK-MDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQE 914
Query: 338 LDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQ------YER 391
L + + ++ E +E KK MLEEK ++N H+++ + + Y+
Sbjct: 915 LLSMGKVQEKCEK--------LEKDKK--MLEEK---VLNLKTHMEKDMVELGKVQEYKS 961
Query: 392 EKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDDF 451
E ER + + +E L+K E LE +N D T KKK ++ F
Sbjct: 962 ELDERAMQAIEKLEEI--HLQKQAEYEKQLE-----QLNKDNTASLKKKELTLKDVECKF 1014
Query: 452 MAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENSM 511
K A L + + F L + + ++ K DKK+ +++ K ME
Sbjct: 1015 SKMKTAYEDVTTELEEYKEAFAVALKANSSMSEKITK--SDKKI---AVISTKLFMEK-- 1067
Query: 512 VELSKLQEYKSELDER---AMQAVEKLEEIHLQEQ 543
+++ + S L R + VE L I L +
Sbjct: 1068 ---ERMEYFLSTLPMRPDPELPCVENLNSIELNRK 1099
Score = 32.3 bits (72), Expect = 1.2
Identities = 80/382 (20%), Positives = 160/382 (41%), Gaps = 62/382 (16%)
Query: 222 LKKEHDREELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIG 281
+K E+ ++ +RK+ + +KE + V S + + + R+ Q S Y +KK
Sbjct: 402 MKPENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEM 461
Query: 282 FRN----------------SPNDLSQTQ----QQIKEMKEMYENAEAKVNNS----TGKW 317
F N ND + + Q+IK + E+ N E V + T K
Sbjct: 462 FGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKV 521
Query: 318 SCVEERICQLQHENPCIEQQLD-DVHQKED--------HKEIVTNIQRGFIESGKKDLML 368
+ +++ L+ EN + +L+ + H KE H + T I +KDL L
Sbjct: 522 AQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLEL 581
Query: 369 ----------EEKNKKLMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKLTMLE 418
E +++ E L + + + ++ +E D+L++ T+
Sbjct: 582 VLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTL-- 639
Query: 419 SPLEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLS 478
+ ++L + Q K++ Q+ + KE+ S N ++E ++ Q+EL +
Sbjct: 640 ----ALESVQLDLKQAQHRIKEMKQMHPNGE----AKESQSIGKQNSSEE-RIRQRELEN 690
Query: 479 MKKVQQ-ECEKLEEDKKMLEEEILNL-KTHMENSMVELSKLQEYKSELDERAMQAVEKLE 536
+ +Q E + E D K E ++N+ + +EN +L L+E EL EKL
Sbjct: 691 LLLERQLEDARKEGDNK---EIVINIHRDCLENGKEDL--LEERNKELMNEYNYLKEKLL 745
Query: 537 EIHLQEQAEHKKQLEQLNKDII 558
+ + +E+AE + + + ++++
Sbjct: 746 Q-YEKEKAEREVIVREFQEELV 766
>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 253 bits (645), Expect = 4e-67
Identities = 203/592 (34%), Positives = 292/592 (49%), Gaps = 169/592 (28%)
Query: 131 EDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEG------------- 177
E A+K A +K + +AE L VA EE+QER +RSE KQ Q +
Sbjct: 377 ETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFM 436
Query: 178 ----------------NNTNKSEK--IQLSENVCHSTSSAAADRLTKQRKVGKT---YPQ 216
N++ + EK IQ +++ ++ ++ + KT Y Q
Sbjct: 437 LKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQ 496
Query: 217 QFP----------KKLKKE-HDREELERKEK-----------QYKKEVEAKQLEPTVQSL 254
Q +L+KE H++E LE + + +Y + VE K LE +
Sbjct: 497 QLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRA 556
Query: 255 D------------------------------MKLKTTRNTPNQINQSLRYSQKKVIGFRN 284
D +K T + + +LR +K + +
Sbjct: 557 DDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALR---EKTLALGS 613
Query: 285 SPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQK 344
DL Q Q +IKEMK+M+ N EAK + S GK + +EERI Q + EN +E+QL+D ++
Sbjct: 614 VQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKE 673
Query: 345 EDHKEIVTNIQRGFIESGKKDLM-------LEEKN--KKLMNEC---------------- 379
D+KEIV NI R +E+GK+DL+ ++E N K+ + +C
Sbjct: 674 GDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE 733
Query: 380 ---DHLK--------------------------ESLFQYE----------REKAERVVVV 400
DHLK + LFQ E R+ E + ++
Sbjct: 734 ELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLL 793
Query: 401 -----------RQLQQEAADSLKKLTMLESPLEGISHY----HINLDETQVPKKKLFQ-V 444
R+L++EA K L M + L ++ H +L+ Q+ LF+ +
Sbjct: 794 NYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKL 853
Query: 445 ESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLK 504
+ +F+D +AEKEAVSS+CVNLAK+ +V QELLSM+ VQ++CEKLE+DKKMLEEE+LNLK
Sbjct: 854 KQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLK 913
Query: 505 THMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKD 556
THME MVEL KLQEYKSELDERA+Q +EKLEEIHLQ+QAE++KQLEQLNKD
Sbjct: 914 THMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKD 965
>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1002
Score = 253 bits (645), Expect = 4e-67
Identities = 203/592 (34%), Positives = 292/592 (49%), Gaps = 169/592 (28%)
Query: 131 EDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEG------------- 177
E A+K A +K + +AE L VA EE+QER +RSE KQ Q +
Sbjct: 270 ETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFM 329
Query: 178 ----------------NNTNKSEK--IQLSENVCHSTSSAAADRLTKQRKVGKT---YPQ 216
N++ + EK IQ +++ ++ ++ + KT Y Q
Sbjct: 330 LKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQ 389
Query: 217 QFP----------KKLKKE-HDREELERKEK-----------QYKKEVEAKQLEPTVQSL 254
Q +L+KE H++E LE + + +Y + VE K LE +
Sbjct: 390 QLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRA 449
Query: 255 D------------------------------MKLKTTRNTPNQINQSLRYSQKKVIGFRN 284
D +K T + + +LR +K + +
Sbjct: 450 DDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALR---EKTLALGS 506
Query: 285 SPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQK 344
DL Q Q +IKEMK+M+ N EAK + S GK + +EERI Q + EN +E+QL+D ++
Sbjct: 507 VQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKE 566
Query: 345 EDHKEIVTNIQRGFIESGKKDLM-------LEEKN--KKLMNEC---------------- 379
D+KEIV NI R +E+GK+DL+ ++E N K+ + +C
Sbjct: 567 GDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE 626
Query: 380 ---DHLK--------------------------ESLFQYE----------REKAERVVVV 400
DHLK + LFQ E R+ E + ++
Sbjct: 627 ELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLL 686
Query: 401 -----------RQLQQEAADSLKKLTMLESPLEGISHY----HINLDETQVPKKKLFQ-V 444
R+L++EA K L M + L ++ H +L+ Q+ LF+ +
Sbjct: 687 NYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKL 746
Query: 445 ESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLK 504
+ +F+D +AEKEAVSS+CVNLAK+ +V QELLSM+ VQ++CEKLE+DKKMLEEE+LNLK
Sbjct: 747 KQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLK 806
Query: 505 THMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKD 556
THME MVEL KLQEYKSELDERA+Q +EKLEEIHLQ+QAE++KQLEQLNKD
Sbjct: 807 THMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKD 858
>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 253 bits (645), Expect = 4e-67
Identities = 203/592 (34%), Positives = 292/592 (49%), Gaps = 169/592 (28%)
Query: 131 EDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEG------------- 177
E A+K A +K + +AE L VA EE+QER +RSE KQ Q +
Sbjct: 377 ETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFM 436
Query: 178 ----------------NNTNKSEK--IQLSENVCHSTSSAAADRLTKQRKVGKT---YPQ 216
N++ + EK IQ +++ ++ ++ + KT Y Q
Sbjct: 437 LKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQ 496
Query: 217 QFP----------KKLKKE-HDREELERKEK-----------QYKKEVEAKQLEPTVQSL 254
Q +L+KE H++E LE + + +Y + VE K LE +
Sbjct: 497 QLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRA 556
Query: 255 D------------------------------MKLKTTRNTPNQINQSLRYSQKKVIGFRN 284
D +K T + + +LR +K + +
Sbjct: 557 DDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALR---EKTLALGS 613
Query: 285 SPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQK 344
DL Q Q +IKEMK+M+ N EAK + S GK + +EERI Q + EN +E+QL+D ++
Sbjct: 614 VQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKE 673
Query: 345 EDHKEIVTNIQRGFIESGKKDLM-------LEEKN--KKLMNEC---------------- 379
D+KEIV NI R +E+GK+DL+ ++E N K+ + +C
Sbjct: 674 GDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE 733
Query: 380 ---DHLK--------------------------ESLFQYE----------REKAERVVVV 400
DHLK + LFQ E R+ E + ++
Sbjct: 734 ELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLL 793
Query: 401 -----------RQLQQEAADSLKKLTMLESPLEGISHY----HINLDETQVPKKKLFQ-V 444
R+L++EA K L M + L ++ H +L+ Q+ LF+ +
Sbjct: 794 NYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKL 853
Query: 445 ESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLK 504
+ +F+D +AEKEAVSS+CVNLAK+ +V QELLSM+ VQ++CEKLE+DKKMLEEE+LNLK
Sbjct: 854 KQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLK 913
Query: 505 THMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKD 556
THME MVEL KLQEYKSELDERA+Q +EKLEEIHLQ+QAE++KQLEQLNKD
Sbjct: 914 THMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKD 965
>gi|169178850 PREDICTED: similar to coiled-coil domain containing 29
[Homo sapiens]
Length = 197
Score = 170 bits (430), Expect = 4e-42
Identities = 86/108 (79%), Positives = 100/108 (92%)
Query: 443 QVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILN 502
+++ +FDD MAE+EAVSSKCVNL+K+ QV QQELLSMKKVQQECEKLEE++KMLEEEILN
Sbjct: 33 KLKQKFDDLMAEEEAVSSKCVNLSKDNQVIQQELLSMKKVQQECEKLEENQKMLEEEILN 92
Query: 503 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQL 550
LKTHMENSMVELSKLQEYKSELDERAMQAVEKL+EIHLQ + + +Q+
Sbjct: 93 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLKEIHLQMELDCVEQI 140
>gi|169217383 PREDICTED: similar to coiled-coil domain containing 29
[Homo sapiens]
Length = 185
Score = 169 bits (428), Expect = 6e-42
Identities = 86/108 (79%), Positives = 98/108 (90%)
Query: 443 QVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILN 502
+++ +FDD E+EAVSSKCVNLAK+ QV QQELLSMKKVQQECEKLEEDKKMLEEEILN
Sbjct: 33 KLKQKFDDLTPEEEAVSSKCVNLAKDNQVIQQELLSMKKVQQECEKLEEDKKMLEEEILN 92
Query: 503 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQL 550
LKTHMEN+MVELSKLQEYKSE DERA+QAVEKLEEIHLQ +A+ +Q+
Sbjct: 93 LKTHMENNMVELSKLQEYKSETDERAIQAVEKLEEIHLQMEADCVEQI 140
>gi|239750312 PREDICTED: similar to hCG1744891 [Homo sapiens]
Length = 154
Score = 168 bits (426), Expect = 1e-41
Identities = 86/108 (79%), Positives = 98/108 (90%)
Query: 443 QVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILN 502
+++ +FDD E+EAVSSKCVNLAK+ QV QQELLSMKKVQQECEKLEEDKKMLEEEILN
Sbjct: 33 KLKQKFDDLTPEEEAVSSKCVNLAKDNQVIQQELLSMKKVQQECEKLEEDKKMLEEEILN 92
Query: 503 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQL 550
LKTHMEN+MVELSKLQEYKSE DERA+QAVEKLEEIHLQ +A+ +Q+
Sbjct: 93 LKTHMENNMVELSKLQEYKSEPDERAIQAVEKLEEIHLQMEADCVEQI 140
>gi|239747109 PREDICTED: hypothetical protein XP_002344496 [Homo
sapiens]
Length = 146
Score = 168 bits (426), Expect = 1e-41
Identities = 85/99 (85%), Positives = 95/99 (95%)
Query: 443 QVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILN 502
+++ +FDD MAE+EAVSSKCVNL+K+ QV QQELLSMKKVQQECEKLEE++KMLEEEILN
Sbjct: 33 KLKQKFDDLMAEEEAVSSKCVNLSKDNQVIQQELLSMKKVQQECEKLEENQKMLEEEILN 92
Query: 503 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQ 541
LKTHMENSMVELSKLQEYKSELDERAMQAVEKL+EIHLQ
Sbjct: 93 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLKEIHLQ 131
>gi|239743762 PREDICTED: hypothetical protein XP_002342954 [Homo
sapiens]
Length = 183
Score = 165 bits (417), Expect = 1e-40
Identities = 83/116 (71%), Positives = 100/116 (86%)
Query: 443 QVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILN 502
+++ +FDD AEKEA+SSKCVNLAK+ QV QQE LSMKKVQQ+CEKLEEDKKML+EEILN
Sbjct: 55 KLKQKFDDLTAEKEALSSKCVNLAKDNQVLQQEFLSMKKVQQQCEKLEEDKKMLKEEILN 114
Query: 503 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKDII 558
LKTHMEN+ VELSKLQEYK ELDE+AMQAVEK+EEIHLQ + + +Q+ + K I+
Sbjct: 115 LKTHMENNRVELSKLQEYKLELDEKAMQAVEKIEEIHLQMELDCVEQITRETKRIV 170
>gi|149363632 coiled-coil domain containing 29 [Homo sapiens]
Length = 161
Score = 164 bits (414), Expect = 3e-40
Identities = 82/116 (70%), Positives = 100/116 (86%)
Query: 443 QVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILN 502
+++ +FDD A+KEA+SSKCVNLAK+ QV QQE LSMKKVQQ+CEKLEEDKKML+EEILN
Sbjct: 33 KLKQKFDDLTAQKEALSSKCVNLAKDNQVLQQEFLSMKKVQQQCEKLEEDKKMLKEEILN 92
Query: 503 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKDII 558
LKTHMEN+ VE+SKLQEYK ELDE+AMQAVEKLEEIHLQ + + +Q+ + K I+
Sbjct: 93 LKTHMENNRVEISKLQEYKLELDEKAMQAVEKLEEIHLQMELDCVEQITRETKRIV 148
>gi|239742325 PREDICTED: similar to coiled-coil domain containing 29
[Homo sapiens]
Length = 150
Score = 160 bits (406), Expect = 2e-39
Identities = 82/104 (78%), Positives = 96/104 (92%)
Query: 447 QFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTH 506
+FDD MAE+EAVSSKCVNLAK+ QV QQELLSMKKVQQECEKLEE++KMLEEEILNLKTH
Sbjct: 2 RFDDLMAEEEAVSSKCVNLAKDNQVIQQELLSMKKVQQECEKLEENQKMLEEEILNLKTH 61
Query: 507 MENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQL 550
MENS+VELS+LQ+YKSELDERAMQAVEKL+EI+L + + +Q+
Sbjct: 62 MENSIVELSELQDYKSELDERAMQAVEKLKEINLHMEPDCIEQI 105
>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
Length = 1427
Score = 151 bits (381), Expect = 2e-36
Identities = 123/404 (30%), Positives = 202/404 (50%), Gaps = 81/404 (20%)
Query: 172 SQVKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLK---KEHDR 228
S+++ G + +I++ C AAA R Q + + F + + + HD+
Sbjct: 897 SELENGKQNQERLEIEMESYRCRL---AAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDK 953
Query: 229 EELERKEKQYKKEVEAKQL---EPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGFRNS 285
+++ Q K E+ +++L E + SL ++L TR+ + + L Q+
Sbjct: 954 MKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQR-------- 1005
Query: 286 PNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQKE 345
DLSQTQ Q KE ++MY+ ++K+ K VEER+ QLQ EN + QQLDD H+K
Sbjct: 1006 --DLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKA 1063
Query: 346 DHKEIVTN-IQRGF--------IESGKKDLMLEEKNKKLMNECDHLKESLFQYEREKAER 396
+ +E ++ IQ F ES K+ L L+EKNK+LM+E +HLKE + Q E+EKA R
Sbjct: 1064 NSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGR 1123
Query: 397 VVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKE 456
+ + + Q+ VP + L
Sbjct: 1124 KIDLTEAQE-----------------------------TVPSRCLH-------------- 1140
Query: 457 AVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENSMVELSK 516
++ E+ QQ L SMK +Q++CE L+++KK L++E++NLK++ME +M+E K
Sbjct: 1141 ------LDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGK 1194
Query: 517 LQEYKSELDERAMQAV-EKLEE--IHLQEQAE-HKKQLEQLNKD 556
+ +K ++ERA + + EKL E + LQ+QA +QL QL +D
Sbjct: 1195 AEWHKLLIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQLRED 1238
Score = 54.7 bits (130), Expect = 2e-07
Identities = 75/361 (20%), Positives = 153/361 (42%), Gaps = 54/361 (14%)
Query: 227 DREELERKEKQYKKEVEAK-QLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGFRNS 285
D E+L KE++ K VE K QL+ ++ L +L+T RN + + Q +QK++ +
Sbjct: 722 DSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQL----SE 777
Query: 286 PNDLSQTQQQI-----KEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDD 340
D Q QI KE++ + +++++ K + C LQ E + ++D
Sbjct: 778 EQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDT 837
Query: 341 VHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKL-----MNECDHLKESLFQYEREKAE 395
+ + KE + + E + ++EKN L +NE + L E++ QY +
Sbjct: 838 IKNQNKQKE------KKYFEDIE---AVKEKNDNLQKIIKLNE-ETLTETILQYSGQLNN 887
Query: 396 RVVVVRQLQQEAADSLKKLTMLESPLEG----ISHYHINLDETQVPK--KKLFQ------ 443
+ L E + + LE +E ++ + D++Q + K FQ
Sbjct: 888 LTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEW 947
Query: 444 ------VESQFDDFMAEKEAVSSKCVNLAKEIQVFQ-----------QELLSMKKVQQEC 486
++ A+ E +S K N +I Q +E L +++VQ++
Sbjct: 948 VRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDL 1007
Query: 487 EKLEEDKKMLEEEILNLKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEH 546
+ + KK E+ ++ ++ + + ++E S+L M ++L++ H + ++
Sbjct: 1008 SQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQE 1067
Query: 547 K 547
K
Sbjct: 1068 K 1068
Score = 41.6 bits (96), Expect = 0.002
Identities = 94/508 (18%), Positives = 199/508 (39%), Gaps = 120/508 (23%)
Query: 149 AEQTLPVALEEE-QERCERSEKKQSQVKEGNNTNKSEKIQLSENV------CHSTSSAAA 201
+++T V L EE Q+ ++ + + + ++E K E +QL ++V S S+ +
Sbjct: 483 SDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELS 542
Query: 202 DRLTKQRKVGKT---YPQQFPKKLKKEHDR-------EELERKEKQYKKEVEAKQLEPT- 250
LT VG QQ P+K EHDR E+ E K + Y + A +EP+
Sbjct: 543 GTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSE 602
Query: 251 -------------------VQSLDMKLKTTRNTP--------------------NQINQS 271
++ L M+ K + + P +Q+
Sbjct: 603 IASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVK 662
Query: 272 LRYSQKKVIGFRNSPNDLSQTQ-----QQIKEMKEMYE-------------NAEAKVNNS 313
L+ + V +N ++ +T+ Q+I+ KE+Y+ NA+ N
Sbjct: 663 LKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKD 722
Query: 314 TG-------------------KWSC--VEERICQLQHENPCIEQQLDDVHQKEDHKEIVT 352
+ KW+ + + + +++ + Q+ +D ++ ++
Sbjct: 723 SEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDAR 782
Query: 353 NIQRGFIESGKKDLMLEEKNKKLMNECDH---LKESLFQYEREKAERVVVVR-QLQQEAA 408
+Q + S +K+ LE KK+ +E H ++ LF + E + ++R ++
Sbjct: 783 ILQDQILTSKQKE--LEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKN 840
Query: 409 DSLKKLTMLESPLEGISHYHINLDE-----TQVPKKKLFQVESQFDDFMAEKEAVSSKCV 463
+ +K +E + + NL + + + + Q Q ++ AE + ++S+
Sbjct: 841 QNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELE 900
Query: 464 NLAKEIQVFQQELLS----MKKVQQECEK------LEEDKKMLEEEILNLKTHMENSMVE 513
N + + + E+ S + ++C++ L+ D + +E + L M+ V+
Sbjct: 901 NGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMK---VD 957
Query: 514 LSKLQEYKSELDERAMQAVEKLEEIHLQ 541
+S LQ L E+ A K+ + +Q
Sbjct: 958 MSGLQAKNEILSEKLSNAESKINSLQIQ 985
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 142 bits (358), Expect = 8e-34
Identities = 126/466 (27%), Positives = 227/466 (48%), Gaps = 59/466 (12%)
Query: 127 STEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQS----QVKEGNNTNK 182
S E+E + A++ K + R ++ L Q +C+ E +Q QVK K
Sbjct: 1075 SLEIEFHHTRDALREKTLGLERVQKDL------SQTQCQMKEMEQKYQNEQVKVNKYIGK 1128
Query: 183 SEKIQ------LSENVC-HSTSSAAADRLTKQRKVGKTYPQQFP---KKLKKEHDREEL- 231
E ++ SEN+ A ++ + K QF +KL+ E +++ L
Sbjct: 1129 QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL 1188
Query: 232 --ER-----------KEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKK 278
ER KE+QY+ E E + E V+ L +L T + SL + +
Sbjct: 1189 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRY 1248
Query: 279 VIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENP----CI 334
I + DL + QI+ + ++ + K +++ +L+ +N +
Sbjct: 1249 RINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEK---MQDHKQKLEKDNAKLKVTV 1305
Query: 335 EQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYEREKA 394
++Q+D + +E+ N+ + +K E+ KKLM L+ +L Q ++
Sbjct: 1306 KKQMDKI------EELQKNLLNANLSEDEK-----EQLKKLMELKQSLECNLDQEMKKNV 1354
Query: 395 ERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKK-KLFQVESQFDDFMA 453
E + + + KKL E+ G +H +L +Q ++ +++ + DD A
Sbjct: 1355 ELEREITGFKNLLKMTRKKLNEYEN---GEFSFHGDLKTSQFEMDIQINKLKHKIDDLTA 1411
Query: 454 EKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENSMVE 513
E E SKC++L + Q+ Q+ELLSMK VQ++CEKL+++KK LE+E++NL++H+E +MVE
Sbjct: 1412 ELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVE 1471
Query: 514 LSKLQEYKSELDERAMQAV-EKLEEIH--LQEQAEHKKQLEQLNKD 556
L ++++YK E++ERA Q + EKL+E++ LQ QA ++ LEQ ++
Sbjct: 1472 LGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFREN 1517
Score = 87.8 bits (216), Expect = 2e-17
Identities = 134/534 (25%), Positives = 238/534 (44%), Gaps = 103/534 (19%)
Query: 118 PAKHPSLKPSTEVEDPAVKGAVQRKNVQTLR-AEQTLPVALEEEQERCERSEKKQSQVKE 176
P ++ LKP+ E++D A K+VQT + AE L VA EEEQER E SE Q QV+E
Sbjct: 490 PERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQER-EGSENNQPQVEE 548
Query: 177 GNNTNKSEKIQLSENVCHSTSSAAA-----DRLTKQRKVGKTYPQQFPKKLKKEH----- 226
+++ ++++S N+ + A D L ++RK G+T QQFP+K KE+
Sbjct: 549 ERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSGP 608
Query: 227 --DREELERKEKQYKKEVEAKQ--------------LEPTVQSLDMKLKTTRNTPNQINQ 270
+E++ EK+ + E+ L+ S ++ P +
Sbjct: 609 ALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTS 668
Query: 271 SLRYSQKKVIGFRNSPNDLSQTQQQIKEMKEM----YEN---------AEAKVNNSTGK- 316
+ + K I + +DL+Q+ + E E+ Y+N E K + S K
Sbjct: 669 NEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKI 728
Query: 317 ----WSCVEERICQLQHENPC------IEQQLDDVH--QKE--DHKEIVTNIQRGFIESG 362
SC ER+ +L+ +N C I++ D V+ Q+E + KEI + ++ +E
Sbjct: 729 QDAALSC--ERLLELK-KNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWE 785
Query: 363 KKDLML-------EEKNKKLMNECDHLKESLFQYEREKAERVVVVRQLQ----------- 404
++ L EEK + + ++E L + E + + V V +QL+
Sbjct: 786 RELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELR 845
Query: 405 ----------QEAADSLKKLTMLESP---LEGISHYHINLD-ETQVPKKKLFQVESQFDD 450
QE D+ ++L+ ++ +GI H++ E ++ +KK+ S +
Sbjct: 846 TVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHE 905
Query: 451 FMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECE-KLEEDKKMLEEEILNL-KTHME 508
E++ +S K L +EI + + E+ ++K QE E K ED K+++E+ +L KT +
Sbjct: 906 ---EEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQ 962
Query: 509 NSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQ-LEQLNKDIIQLH 561
N + +Y L +V E L + E++KQ E+L ++ H
Sbjct: 963 NEETLTQTISQYNGRL------SVLTAENAMLNSKLENEKQSKERLEAEVESYH 1010
>gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH
polyclonal antibodies [Homo sapiens]
Length = 1430
Score = 129 bits (325), Expect = 5e-30
Identities = 114/413 (27%), Positives = 203/413 (49%), Gaps = 41/413 (9%)
Query: 129 EVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNTNKSEKIQL 188
E ED + + + + LR E+ E++ + E + + ++ K + L
Sbjct: 1018 EKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNEETL 1077
Query: 189 SENV-CHSTSSAAA--------DRLTKQRKVGK---TYPQQFPKKLKK---EHDREELER 233
+E + C+S AA +L KQR+ G+ T Q + +L +HD+ +
Sbjct: 1078 AETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEMQSYRCRLNAALCDHDQSHSSK 1137
Query: 234 KEKQ--YKKEVEA-----KQLEPTVQSLDMKLKTTRNTPNQINQSLRYS----QKKVIGF 282
++++ ++ V+ + L V L ++L + + L Y+ ++K + F
Sbjct: 1138 RDQELAFQGTVDKCCHLQENLNSHVLILSLQLSKAESKFRVLETELHYTGEALKEKALVF 1197
Query: 283 RNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVH 342
+ ++L Q Q Q+K++++MY++ + K +ER CQL+ +N ++QQLDD
Sbjct: 1198 EHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK----QERFCQLKKQNMLLQQQLDDAR 1253
Query: 343 QKEDHKE-IVTNIQRGF--------IESGKKDLMLEEKNKKLMNECDHLKESLFQYEREK 393
K D++E + NIQ E K L+LEE NK L+NE +H KE QYE+EK
Sbjct: 1254 NKADNQEKAILNIQARCDARVENLQAECRKHRLLLEEDNKMLVNELNHSKEKKCQYEKEK 1313
Query: 394 AERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDE-TQVPKKKLFQVESQFDDFM 452
AER V VRQLQQ+ D L K + ++ L+ S + I L+ Q +KKL Q+ SQF +
Sbjct: 1314 AEREVAVRQLQQKQDDVLNKRSATKALLDASSRHCIYLENGMQDSRKKLDQMRSQFQEIQ 1373
Query: 453 AEKEAVSSKCVNLAKEIQVFQQELLSMKK-VQQECEKLEEDKKMLEEEILNLK 504
+ A + + Q + E + M+K ++++ E++E +K+L+ L L+
Sbjct: 1374 DQLTATIRCTKEMEGDAQKLEVENVMMRKIIKKQDEQIERFEKILQHSSLMLQ 1426
Score = 46.2 bits (108), Expect = 8e-05
Identities = 106/495 (21%), Positives = 202/495 (40%), Gaps = 70/495 (14%)
Query: 108 RIVNGKGKGP--PAKHPSLKPSTEVEDPAVKGAVQRKNVQTLR-AEQTLPVALEEEQERC 164
RI G G P P+LK + E ++ + A + K+VQT AEQ L +A E EQ+R
Sbjct: 764 RITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRL 823
Query: 165 ERSEKKQSQVKE--GNNTNKSEKIQLSENVCHSTSSAAAD-----RLTKQR--------- 208
E E Q QVK + + + IQ S+ V S + L Q
Sbjct: 824 EEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVH 883
Query: 209 --KVGKTY-------------PQQFPKKLKKEHDREELERKEKQYKKEVEAKQLEPTVQS 253
K+ KT+ +Q K++K ++ + +K K+E+++ QL+
Sbjct: 884 LLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSEKEEIKS-QLKHETLE 942
Query: 254 LDMKLKTTRNTPNQINQSLR----YSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAK 309
L+ +L + R Q + R QK R + K +K ++AE +
Sbjct: 943 LEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVE 1002
Query: 310 V---NNSTGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDL 366
+ N++ + S +E+ L HEN ++ ++ + ++D + N+++ ++ KD
Sbjct: 1003 LKTGGNNSNQVSETDEKE-DLLHENRLMQDEIARLRLEKDTIK-NQNLEKKYL----KDF 1056
Query: 367 ML-----EEKNKKLMNECDHLKESLFQYEREKA----ERVVVVRQLQQEAADSLKKLTML 417
+ E+ K L + L E++ Y + A E + +L+++ + T +
Sbjct: 1057 EIVKRKHEDLQKALKRNEETLAETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEM 1116
Query: 418 ESPLEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQEL- 476
+S ++ + D++ K+ D +A + V KC +L + + L
Sbjct: 1117 QSYRCRLNAALCDHDQSHSSKR---------DQELAFQGTV-DKCCHLQENLNSHVLILS 1166
Query: 477 LSMKKVQQECEKLEEDKKMLEEEILNLKTHMENSMVELSKLQEYKSELDERAMQAVEKLE 536
L + K + + LE + E + E+ EL + Q ++++ +E
Sbjct: 1167 LQLSKAESKFRVLETELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTME 1226
Query: 537 E-IHLQEQ-AEHKKQ 549
+ I QE+ + KKQ
Sbjct: 1227 KCIEKQERFCQLKKQ 1241
Score = 45.4 bits (106), Expect = 1e-04
Identities = 102/506 (20%), Positives = 185/506 (36%), Gaps = 74/506 (14%)
Query: 120 KHPSLKPSTEVEDPAVKGAVQRKNVQ-----TLRAEQTLPVALEEEQERCERS-EKKQSQ 173
K P+LK +T+ ED A + K+ + + R + L +E+ + EKK +
Sbjct: 472 KQPALKATTDEEDSVSIIATEIKDGEKSGTVSSRKKPALKATSDEKDSFSNITREKKDGE 531
Query: 174 VKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHDREELER 233
+ ++ K ++ + + S S A + K + +T + P LK D ++
Sbjct: 532 ISRTVSSQKPPALKATSDEEDSVLSIAREE--KDGEKSRTVSSEQPPGLKATRDEKDSLL 589
Query: 234 KEKQYKKEVE-----AKQLEPTVQSLDMKLKTTRN-------------TPNQINQSLRYS 275
+ KK E + +P +++ K + N +Q +L+ +
Sbjct: 590 NIARGKKYGEKTRRVSSHKQPALKATSDKENSVPNMATETKDEQISGTVSSQKQPALKAT 649
Query: 276 QKKVIGFRNSPNDLSQTQQQ--IKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPC 333
K N P ++ QQ + K++ A + +S S + I Q
Sbjct: 650 SDKKDSVSNIPTEIKDGQQSGTVSSQKQLAWKATSVKKDSV---SNIATEIKDGQIRGTV 706
Query: 334 IEQQLDDVHQKEDHKEIVTNIQRGFIESGKKD-----------LMLEEKNKKLMNECDHL 382
Q+ + D K+ V+NI R I+ G+K ++ +K L+N +
Sbjct: 707 SSQRQPALKATGDEKDSVSNIARE-IKDGEKSGTVSPQKQSAQKVIFKKKVSLLNIATRI 765
Query: 383 K---ESLFQYER---------EKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHIN 430
+S +Y E V+ ++ S LE EG
Sbjct: 766 TGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRLEE 825
Query: 431 LDETQVPKKKLFQVESQFDDFMAEKEAVS----SKCVNLAKEIQVFQQE---------LL 477
+ Q K DD + + VS S C N I + Q LL
Sbjct: 826 YENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVHLL 885
Query: 478 SMKKVQQECEKLEEDK----KMLEEEILNLKTHMENSMVELSKLQEYKSELDERAMQAVE 533
+KK C++L E K + L +I LK LS+ +E KS+L ++ +
Sbjct: 886 KIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSEKEEIKSQLKHETLELEK 945
Query: 534 KLEEIHLQEQAEHKKQ--LEQLNKDI 557
+L + Q E KK+ +E+L++ +
Sbjct: 946 ELCSLRFAIQQEKKKRRNVEELHQKV 971
>gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH
polyclonal antibodies [Homo sapiens]
Length = 868
Score = 125 bits (315), Expect = 8e-29
Identities = 113/413 (27%), Positives = 201/413 (48%), Gaps = 41/413 (9%)
Query: 129 EVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNTNKSEKIQL 188
E ED + + + + LR E+ E++ + E + + ++ K + L
Sbjct: 456 EKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNEETL 515
Query: 189 SENV-CHSTSSAAA--------DRLTKQRKVGK---TYPQQFPKKLKK---EHDREELER 233
+E + C+S AA +L KQR+ G+ T Q + +L +HD+ +
Sbjct: 516 AETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEMQSYRCRLNAALCDHDQSHSSK 575
Query: 234 KEKQ--YKKEVEA-----KQLEPTVQSLDMKLKTTRNTPNQINQSLRYS----QKKVIGF 282
++++ ++ V+ + L V L ++L + + L Y+ ++K + F
Sbjct: 576 RDQELAFQGTVDKCCHLQENLNSHVLILSLQLSKAESKFRVLETELHYTGEALKEKALVF 635
Query: 283 RNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVH 342
+ ++L Q Q Q+K++++MY++ + K +ER CQL+ +N ++QQLDD
Sbjct: 636 EHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK----QERFCQLKKQNMLLQQQLDDAR 691
Query: 343 QKEDHKE-IVTNIQRGF--------IESGKKDLMLEEKNKKLMNECDHLKESLFQYEREK 393
K D++E + NIQ E K L+LEE NK L+NE H KE QYE+EK
Sbjct: 692 NKADNQEKAILNIQARCDARVENLQAECRKHRLLLEEDNKMLVNELTHSKEKECQYEKEK 751
Query: 394 AERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDE-TQVPKKKLFQVESQFDDFM 452
AER V VRQLQQ+ D L K + ++ L+ S + L+ Q +KKL Q+ SQF +
Sbjct: 752 AEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSQFQEIQ 811
Query: 453 AEKEAVSSKCVNLAKEIQVFQQELLSMKK-VQQECEKLEEDKKMLEEEILNLK 504
+ A + + Q + E + M+K ++++ E++E +K+L+ L L+
Sbjct: 812 DQLTATIRCTKEMEGDAQKLEVENVMMRKIIKKQDEQIERFEKILQHSSLMLQ 864
Score = 46.2 bits (108), Expect = 8e-05
Identities = 106/495 (21%), Positives = 202/495 (40%), Gaps = 70/495 (14%)
Query: 108 RIVNGKGKGP--PAKHPSLKPSTEVEDPAVKGAVQRKNVQTLR-AEQTLPVALEEEQERC 164
RI G G P P+LK + E ++ + A + K+VQT AEQ L +A E EQ+R
Sbjct: 202 RITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRL 261
Query: 165 ERSEKKQSQVKE--GNNTNKSEKIQLSENVCHSTSSAAAD-----RLTKQR--------- 208
E E Q QVK + + + IQ S+ V S + L Q
Sbjct: 262 EEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVH 321
Query: 209 --KVGKTY-------------PQQFPKKLKKEHDREELERKEKQYKKEVEAKQLEPTVQS 253
K+ KT+ +Q K++K ++ + +K K+E+++ QL+
Sbjct: 322 LLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSEKEEIKS-QLKHETLE 380
Query: 254 LDMKLKTTRNTPNQINQSLR----YSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAK 309
L+ +L + R Q + R QK R + K +K ++AE +
Sbjct: 381 LEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVE 440
Query: 310 V---NNSTGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDL 366
+ N++ + S +E+ L HEN ++ ++ + ++D + N+++ ++ KD
Sbjct: 441 LKTGGNNSNQVSETDEKE-DLLHENRLMQDEIARLRLEKDTIK-NQNLEKKYL----KDF 494
Query: 367 ML-----EEKNKKLMNECDHLKESLFQYEREKA----ERVVVVRQLQQEAADSLKKLTML 417
+ E+ K L + L E++ Y + A E + +L+++ + T +
Sbjct: 495 EIVKRKHEDLQKALKRNEETLAETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEM 554
Query: 418 ESPLEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQEL- 476
+S ++ + D++ K+ D +A + V KC +L + + L
Sbjct: 555 QSYRCRLNAALCDHDQSHSSKR---------DQELAFQGTV-DKCCHLQENLNSHVLILS 604
Query: 477 LSMKKVQQECEKLEEDKKMLEEEILNLKTHMENSMVELSKLQEYKSELDERAMQAVEKLE 536
L + K + + LE + E + E+ EL + Q ++++ +E
Sbjct: 605 LQLSKAESKFRVLETELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTME 664
Query: 537 E-IHLQEQ-AEHKKQ 549
+ I QE+ + KKQ
Sbjct: 665 KCIEKQERFCQLKKQ 679
Score = 37.4 bits (85), Expect = 0.037
Identities = 40/160 (25%), Positives = 63/160 (39%), Gaps = 19/160 (11%)
Query: 417 LESPLEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVS----SKCVNLAKEIQVF 472
LE EG + Q K DD + + VS S C N I +
Sbjct: 250 LEMASEGEQKRLEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLI 309
Query: 473 QQE---------LLSMKKVQQECEKLEEDK----KMLEEEILNLKTHMENSMVELSKLQE 519
Q LL +KK C++L E K + L +I LK LS+ +E
Sbjct: 310 DQHEMKCKDCVHLLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSEKEE 369
Query: 520 YKSELDERAMQAVEKLEEIHLQEQAEHKKQ--LEQLNKDI 557
KS+L ++ ++L + Q E KK+ +E+L++ +
Sbjct: 370 IKSQLKHETLELEKELCSLRFAIQQEKKKRRNVEELHQKV 409
>gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]
Length = 1524
Score = 121 bits (304), Expect = 1e-27
Identities = 89/302 (29%), Positives = 158/302 (52%), Gaps = 26/302 (8%)
Query: 225 EHDREELERKEKQ--YKKEVEA-----KQLEPTVQSLDMKLKTTRNTPNQINQSLRYS-- 275
+HD+ +++++ ++ V+ + L V L ++L + + L Y+
Sbjct: 1223 DHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGE 1282
Query: 276 --QKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPC 333
++K + F + ++L Q Q Q+K++++MY++ + K +ER CQL+ +N
Sbjct: 1283 ALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK----QERFCQLKKQNML 1338
Query: 334 IEQQLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDLMLEEKNKKLMNECDHLKE 384
++QQLDD K D++E + NIQ E K L+LEE NK L+NE +H KE
Sbjct: 1339 LQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKE 1398
Query: 385 SLFQYEREKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDE-TQVPKKKLFQ 443
QYE+EKAER V VRQLQQ+ D L K + ++ L+ S + L+ Q +KKL Q
Sbjct: 1399 KECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQ 1458
Query: 444 VESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKK-VQQECEKLEEDKKMLEEEILN 502
+ SQF + + A + + Q + E + M+K ++++ +++E +K+L+ L
Sbjct: 1459 MRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQHSSLM 1518
Query: 503 LK 504
L+
Sbjct: 1519 LQ 1520
Score = 48.5 bits (114), Expect = 2e-05
Identities = 100/444 (22%), Positives = 183/444 (41%), Gaps = 60/444 (13%)
Query: 108 RIVNGKGKGP--PAKHPSLKPSTEVEDPAVKGAVQRKNVQTLR-AEQTLPVALEEEQERC 164
RI G G P P+LK + E ++ + A + K+VQT AEQ L +A E EQ+R
Sbjct: 858 RITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRL 917
Query: 165 ERSEKKQSQVKE--GNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKL 222
E E Q QVK + + + IQ S+ V S D L K Q K
Sbjct: 918 EEYENNQPQVKNQIHSRDDLDDIIQSSQTV-----SEDGDSLCCNCKNVILLIDQHEMKC 972
Query: 223 KKEHDREELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGF 282
K +++ +K+ ++ K + + L +K++ +N + + + R S+K+ I
Sbjct: 973 KDCVHLLKIKNTFCLWKRLIKLK--DNHCEQLRVKIRKLKNKASVLQK--RISEKEEI-- 1026
Query: 283 RNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVH 342
SQ + +I E+++ + + K VEE H+ + ++L
Sbjct: 1027 ------KSQLKHEILELEKELCSLRFAIQQEKKKRRNVEE-----VHQK--VREKLRITE 1073
Query: 343 QKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYEREKAERVVVVRQ 402
++ + VT + ++S + +L N ++E D KE L R + + +R
Sbjct: 1074 EQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDE-KEDLLHENRLMQDEIARLR- 1131
Query: 403 LQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVSSKC 462
L+K T+ LE Y L + ++ K+K +D ++A+
Sbjct: 1132 --------LEKDTIKNQNLE--KKY---LKDFEIVKRK-------HEDL---QKALKRNG 1168
Query: 463 VNLAKEIQVFQQELLSM----KKVQQECEKLEEDKKMLEEEILNLKTHMENSMVELSKLQ 518
LAK I + +L ++ ++ + EK E ++ LE E+ + + + + +
Sbjct: 1169 ETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSH 1228
Query: 519 EYKSELDERAMQAVEKLEEIHLQE 542
K + + V+K HLQE
Sbjct: 1229 SSKRDQELAFQGTVDKCR--HLQE 1250
Score = 30.4 bits (67), Expect = 4.5
Identities = 91/466 (19%), Positives = 179/466 (38%), Gaps = 68/466 (14%)
Query: 120 KHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQV----- 174
K P+LK +++ ED + A + K+ E++ V+ E+ S++K S +
Sbjct: 642 KPPALKGTSDEEDSVLGIARENKD-----GEKSRTVSSEKPPGLKATSDEKDSVLNIARG 696
Query: 175 -KEGNNTN--KSEKIQLSENVCHSTSSA---AADRLTKQRKVGKTYPQQFPKKLKKEHDR 228
K+G T S K + +C S A ++ K ++ T Q LK D+
Sbjct: 697 KKDGEKTRTVSSPKQPALKAICDKEDSVPNMATEK--KDEQISGTVSCQKQPALKATSDK 754
Query: 229 EE------LERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQS-------LRYS 275
++ E K+ Q V + Q +P ++ +K + N +I L Y+
Sbjct: 755 KDSVSNIPTEIKDGQQSGTVSS-QKQPAWKATSVKKDSVSNIATEIKDGQIRGTGILEYT 813
Query: 276 --------QKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQL 327
++K S Q Q K + + + TG W E L
Sbjct: 814 FNVMFDQIEEKFTSLNKSAGVSPQKQSAQKVIFKKKVSLLNIATRITGGWKSGTEYPENL 873
Query: 328 QHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDL-MLEEKNKKLMNECDHLKESL 386
IE + ++ K++ T+ ++DL M E +K + E ++ + +
Sbjct: 874 PTLKATIENKNSVLNTATKMKDVQTSTP------AEQDLEMASEGEQKRLEEYENNQPQV 927
Query: 387 FQ--YEREKAERVVVVRQLQQEAADSL----KKLTMLESPLEGISHYHINLDETQVPKKK 440
+ R+ + ++ Q E DSL K + +L +D+ ++ K
Sbjct: 928 KNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILL-------------IDQHEMKCKD 974
Query: 441 LFQVESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKV-QQECEKLEEDKKMLEEE 499
+ + F K + K N ++++V ++L + V Q+ + EE K L+ E
Sbjct: 975 CVHLLKIKNTFCLWKRLIKLKD-NHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 1033
Query: 500 ILNLKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAE 545
IL L+ + + + + ++ + ++E + EKL Q + E
Sbjct: 1034 ILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIE 1079
>gi|124517695 ankyrin repeat domain 36B [Homo sapiens]
Length = 1121
Score = 121 bits (304), Expect = 1e-27
Identities = 89/302 (29%), Positives = 158/302 (52%), Gaps = 26/302 (8%)
Query: 225 EHDREELERKEKQ--YKKEVEA-----KQLEPTVQSLDMKLKTTRNTPNQINQSLRYS-- 275
+HD+ +++++ ++ V+ + L V L ++L + + L Y+
Sbjct: 820 DHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGE 879
Query: 276 --QKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPC 333
++K + F + ++L Q Q Q+K++++MY++ + K +ER CQL+ +N
Sbjct: 880 ALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK----QERFCQLKKQNML 935
Query: 334 IEQQLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDLMLEEKNKKLMNECDHLKE 384
++QQLDD K D++E + NIQ E K L+LEE NK L+NE +H KE
Sbjct: 936 LQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKE 995
Query: 385 SLFQYEREKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDE-TQVPKKKLFQ 443
QYE+EKAER V VRQLQQ+ D L K + ++ L+ S + L+ Q +KKL Q
Sbjct: 996 KECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQ 1055
Query: 444 VESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKK-VQQECEKLEEDKKMLEEEILN 502
+ SQF + + A + + Q + E + M+K ++++ +++E +K+L+ L
Sbjct: 1056 MRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQHSSLM 1115
Query: 503 LK 504
L+
Sbjct: 1116 LQ 1117
Score = 48.1 bits (113), Expect = 2e-05
Identities = 100/444 (22%), Positives = 182/444 (40%), Gaps = 60/444 (13%)
Query: 108 RIVNGKGKGP--PAKHPSLKPSTEVEDPAVKGAVQRKNVQTLR-AEQTLPVALEEEQERC 164
RI G G P +LK + E +D + A + K VQT AEQ L +A E EQ+R
Sbjct: 455 RITGGGKSGTEYPENLRTLKATIENKDSVLNTATKMKEVQTSTPAEQDLEMASEGEQKRL 514
Query: 165 ERSEKKQSQVKE--GNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKL 222
E E Q QVK + + + IQ S+ V S D L K Q K
Sbjct: 515 EEYENNQPQVKNQIHSRDDLDDIIQSSQTV-----SEDGDSLCCNCKNVILLIDQHEMKC 569
Query: 223 KKEHDREELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGF 282
K +++ +K+ ++ K + + L +K++ +N + + + R S+K+ I
Sbjct: 570 KDCVHLLKIKNTFCLWKRLIKLK--DNHCEQLRVKIRKLKNKASVLQK--RISEKEEI-- 623
Query: 283 RNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVH 342
SQ + +I E+++ + + K VEE H+ + ++L
Sbjct: 624 ------KSQLKHEILELEKELCSLRFAIQQEKKKRRNVEE-----LHQK--VREKLRITE 670
Query: 343 QKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYEREKAERVVVVRQ 402
++ + VT + ++S + +L N ++E D KE L R + + +R
Sbjct: 671 EQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDE-KEDLLHENRLMQDEIARLR- 728
Query: 403 LQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDDFMAEKEAVSSKC 462
L+K T+ LE Y L + ++ K+K +D ++A+
Sbjct: 729 --------LEKDTIKNQNLE--KKY---LKDFEIVKRK-------HEDL---QKALKRNG 765
Query: 463 VNLAKEIQVFQQELLSM----KKVQQECEKLEEDKKMLEEEILNLKTHMENSMVELSKLQ 518
LAK I + +L ++ ++ + EK E ++ LE E+ + + + + + +
Sbjct: 766 ETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYRCRLNAARCDHDQSH 825
Query: 519 EYKSELDERAMQAVEKLEEIHLQE 542
K + + V+K HLQE
Sbjct: 826 SSKRDQELAFQGTVDKCR--HLQE 847
Score = 37.4 bits (85), Expect = 0.037
Identities = 91/469 (19%), Positives = 185/469 (39%), Gaps = 79/469 (16%)
Query: 120 KHPSLKPSTEVEDPAVKGAVQRKNVQ---TLRAEQTLPVALEEEQERCERSEKKQSQVKE 176
K PSLK +++ ED A + K+ Q T+ ++ AL+ ++ + +++K+
Sbjct: 299 KQPSLKATSDKEDSVPNMATETKDEQISGTVSCQK--QPALKATSDKKDSVSNIPTEIKD 356
Query: 177 GNNTNKSEKIQLSENVCHSTSSAAADRLT------KQRKVGKTYPQQFPKKLKKEHDREE 230
G +S + + +S D ++ K ++ T Q LK D ++
Sbjct: 357 G---QQSGTVSSQKQPAWKATSVKKDSVSNIATEIKDGQIRGTVSSQRRPALKTTGDEKD 413
Query: 231 ----LERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKKVIGFRNSP 286
+ R+ K +K + + Q + K K SL ++ G S
Sbjct: 414 SVSNIAREIKDGEKSGTVSPQKQSAQKVIFKKKV----------SLLNIATRITGGGKSG 463
Query: 287 NDLSQTQQQIK---EMKEMYENAEAK---VNNSTGKWSCVE-------ERICQLQHENPC 333
+ + + +K E K+ N K V ST +E +R+ + ++ P
Sbjct: 464 TEYPENLRTLKATIENKDSVLNTATKMKEVQTSTPAEQDLEMASEGEQKRLEEYENNQPQ 523
Query: 334 IEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYEREK 393
++ Q +H ++D +I+ + Q + E L C ++ + Q+E +
Sbjct: 524 VKNQ---IHSRDDLDDIIQSSQ-----------TVSEDGDSLCCNCKNVILLIDQHEMKC 569
Query: 394 AERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDDFMA 453
+ V +++ +K L L + H ++ +V +KL S ++
Sbjct: 570 KDCVHLLK---------IKNTFCLWKRLIKLKDNH--CEQLRVKIRKLKNKASVLQKRIS 618
Query: 454 EKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENSMVE 513
EKE + S+ L EI ++EL S++ Q +E KK E L+ K + + E
Sbjct: 619 EKEEIKSQ---LKHEILELEKELCSLRFAIQ-----QEKKKRRNVEELHQKVREKLRITE 670
Query: 514 LSKLQEYKSELD-ERAMQAVEKLEEIHLQEQAEHKKQLEQLNKDIIQLH 561
++Y+ E D + ++ K E+ L+ + Q+ + ++ LH
Sbjct: 671 ----EQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLH 715
Score = 33.9 bits (76), Expect = 0.41
Identities = 95/497 (19%), Positives = 178/497 (35%), Gaps = 81/497 (16%)
Query: 127 STEVEDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNTNKSEKI 186
+TE++D G V + L+A E++ EKK ++ ++ K +
Sbjct: 181 ATEIKDGEKSGTVSSQKKPALKATSD-----EKDSFSNITREKKDGEISRTVSSQKPPAL 235
Query: 187 QLSENVCHSTSSAAADRLTKQRKVGKTYPQQFPKKLKKEHDREELERKEKQYKKEVE--- 243
+ + S + A ++ K + +T + P LK D ++ + KK+ E
Sbjct: 236 KATSVKEDSVLNIAREK--KDGEKSRTVSFEQPPGLKATRDEKDSLLNIARGKKDGEKTR 293
Query: 244 --AKQLEPTVQSLDMKLKTTRNTPNQINQ-------------SLRYSQKKVIGFRNSPND 288
+ +P++++ K + N + +L+ + K N P +
Sbjct: 294 RVSSHKQPSLKATSDKEDSVPNMATETKDEQISGTVSCQKQPALKATSDKKDSVSNIPTE 353
Query: 289 LSQTQQQ--IKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQKED 346
+ QQ + K+ A + +S S + I Q Q+ + D
Sbjct: 354 IKDGQQSGTVSSQKQPAWKATSVKKDSV---SNIATEIKDGQIRGTVSSQRRPALKTTGD 410
Query: 347 HKEIVTNIQRGFIESGKKD-----------LMLEEKNKKLMNECDHLK---ESLFQYER- 391
K+ V+NI R I+ G+K ++ +K L+N + +S +Y
Sbjct: 411 EKDSVSNIARE-IKDGEKSGTVSPQKQSAQKVIFKKKVSLLNIATRITGGGKSGTEYPEN 469
Query: 392 --------EKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQ 443
E + V+ +E S LE EG + Q K
Sbjct: 470 LRTLKATIENKDSVLNTATKMKEVQTSTPAEQDLEMASEGEQKRLEEYENNQPQVKNQIH 529
Query: 444 VESQFDDFMAEKEAVS----SKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKM--LE 497
DD + + VS S C N I + Q + K +C L + K L
Sbjct: 530 SRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCK----DCVHLLKIKNTFCLW 585
Query: 498 EEILNLK-THMENSMVELSKL--------------QEYKSELDERAMQAVEKLEEIHLQE 542
+ ++ LK H E V++ KL +E KS+L ++ ++L +
Sbjct: 586 KRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAI 645
Query: 543 QAEHKKQ--LEQLNKDI 557
Q E KK+ +E+L++ +
Sbjct: 646 QQEKKKRRNVEELHQKV 662
>gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]
Length = 917
Score = 116 bits (290), Expect = 6e-26
Identities = 95/314 (30%), Positives = 159/314 (50%), Gaps = 27/314 (8%)
Query: 157 LEEEQERCERSEKKQSQVKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVG---KT 213
++E E E++ K+ + T S+++ NV ++ L K+++ +T
Sbjct: 596 IKENNEDLEKTLKRNEETLTKTITRYSKEL----NVLMDENTMLNSELQKEKQSMSRLET 651
Query: 214 YPQQFPKKLKK---EHDREELERKEKQYKKEVEAKQL----EPT---VQSLDMKLKTTRN 263
+ + +L +HD+ + +++ Q + + E T +Q L +L +
Sbjct: 652 EMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAES 711
Query: 264 TPNQINQSLRYSQK----KVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSC 319
T + + L Y ++ K + + LS+TQ+++++++ MY+N + + K
Sbjct: 712 TSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQS 771
Query: 320 VEERICQLQHENPCIEQQLDDVHQKEDHKE-IVTNIQRGFIESGKK----DLMLEEKNKK 374
VE+ + QLQ +N +QQ +D +K D++E + NIQ ++ +K LEE NK
Sbjct: 772 VEDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKG 831
Query: 375 LMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINL-DE 433
LM EC LKE QYE+EK ER VV RQLQ+E D+L K +LE+ LE S INL DE
Sbjct: 832 LMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEISSERRINLEDE 891
Query: 434 TQVPKKKLFQVESQ 447
Q KKKL Q+ SQ
Sbjct: 892 AQSLKKKLGQMRSQ 905
Score = 66.6 bits (161), Expect = 6e-11
Identities = 115/482 (23%), Positives = 207/482 (42%), Gaps = 86/482 (17%)
Query: 156 ALEEEQERCERSEKKQSQVKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTY- 214
++E+++ CER + K ++K NN + +K+ LSE + S + K++ +
Sbjct: 431 SIEDQKCYCERLKVKFQKMK--NNISVLQKV-LSETDKTKSQSEHQNLQGKKKLCNLRFI 487
Query: 215 -PQQFPKKLKKEH----DREELERKEKQYKKEVEAK-QLEPTVQSLDMKLKTTRNTPNQ- 267
QQ +++K E D EEL+ E+QY+ + E K Q + T++SL+++LKT R+ NQ
Sbjct: 488 LQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQN 547
Query: 268 ---------INQSLRYSQKKVIGFRNSPNDLSQTQQQ--------IKEMKEMYENAEAKV 310
+ Q + ++ R + + Q+ I+ +KE E+ E +
Sbjct: 548 FHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTL 607
Query: 311 NNS----TGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFI------- 359
+ T + + + L EN + +L Q E R +
Sbjct: 608 KRNEETLTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDH 667
Query: 360 ---ESGKKDLMLEEKNKKLMNECDHLKES------LFQYEREKAERVV--VVRQLQQEAA 408
+S K+DL L ++ +NE HL+E + + KAE + +L E
Sbjct: 668 DQRQSSKRDLQLAFQST--VNEWCHLQEDTNSHIQILSQQLSKAESTSSGLETELHYER- 724
Query: 409 DSLKKLTM-----------LESPLEGISHYHIN---LDETQVPKKK-----LFQVESQFD 449
++LK+ T+ + LE I H + N + E V K++ LFQ++SQ
Sbjct: 725 EALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNL 784
Query: 450 DFMAEKEAVSSKCVNLAKEIQVFQQELL-SMKKVQQECEKLEEDKKMLEEEILNLKTHM- 507
+ + K N K I Q + +++K+Q EC KLEE+ K L +E LK
Sbjct: 785 LYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQC 844
Query: 508 -------ENSMVELSKLQEYKSELDER----AMQAVEKLEEIHLQEQAEH-KKQLEQLNK 555
E +V +E L+++ AM + I+L+++A+ KK+L Q+
Sbjct: 845 QYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEISSERRINLEDEAQSLKKKLGQMRS 904
Query: 556 DI 557
+
Sbjct: 905 QV 906
Score = 60.5 bits (145), Expect = 4e-09
Identities = 100/475 (21%), Positives = 180/475 (37%), Gaps = 81/475 (17%)
Query: 136 KGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNTNKSEKIQLSENVCHS 195
K +RK++Q +EQ L + E EQER E E Q QV+E +++K+++S NV
Sbjct: 260 KANKRRKSLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRNVHAD 319
Query: 196 TS---SAAADRLTKQRKVGKTYPQQFPKKLKKEHDREELERKEKQYKKEVEAK------- 245
S + D L + K K Q P K E DR L RK K +V+++
Sbjct: 320 DSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDR--LARKTSNEKSKVKSQIYFTDDL 377
Query: 246 -----QLEPTVQ---------------------------SLDMKLKTTRNTPNQINQSLR 273
E T + SL T I
Sbjct: 378 NDISGSSEKTSEDDELPYSDDENFMLLIKQSGMECKDFVSLSKSKNATAACGRSIEDQKC 437
Query: 274 YSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPC 333
Y ++ + F+ N++S Q+ + E + +E + N GK R Q E
Sbjct: 438 YCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQ--NLQGKKKLCNLRFILQQQEEER 495
Query: 334 I------EQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLF 387
I E+ ++++ E+ T +++ + L L+ +L + ++
Sbjct: 496 IKAEELYEKDIEELKIMEEQYRTQTEVKK------QSKLTLKSLEVELKTVRSNSNQNFH 549
Query: 388 QYEREKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQ 447
+ERE R L QE ++ L ++ I H + ET+ K ++ +
Sbjct: 550 THERE--------RDLWQENHLMRDEIARLRLEIDTIKHQN---QETENKYFKDIEIIKE 598
Query: 448 FDDFMAE-----KEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILN 502
++ + + +E ++ +KE+ V E + E +K ++ LE E+ +
Sbjct: 599 NNEDLEKTLKRNEETLTKTITRYSKELNVLMDE---NTMLNSELQKEKQSMSRLETEMES 655
Query: 503 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQL--EQLNK 555
+ + ++ + + Q K +L V E HLQE Q+ +QL+K
Sbjct: 656 YRCRLAAALCDHDQRQSSKRDLQLAFQSTVN--EWCHLQEDTNSHIQILSQQLSK 708
>gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo
sapiens]
Length = 917
Score = 116 bits (290), Expect = 6e-26
Identities = 95/314 (30%), Positives = 159/314 (50%), Gaps = 27/314 (8%)
Query: 157 LEEEQERCERSEKKQSQVKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVG---KT 213
++E E E++ K+ + T S+++ NV ++ L K+++ +T
Sbjct: 596 IKENNEDLEKTLKRNEETLTKTITRYSKEL----NVLMDENTMLNSELQKEKQSMSRLET 651
Query: 214 YPQQFPKKLKK---EHDREELERKEKQYKKEVEAKQL----EPT---VQSLDMKLKTTRN 263
+ + +L +HD+ + +++ Q + + E T +Q L +L +
Sbjct: 652 EMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAES 711
Query: 264 TPNQINQSLRYSQK----KVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSC 319
T + + L Y ++ K + + LS+TQ+++++++ MY+N + + K
Sbjct: 712 TSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQS 771
Query: 320 VEERICQLQHENPCIEQQLDDVHQKEDHKE-IVTNIQRGFIESGKK----DLMLEEKNKK 374
VE+ + QLQ +N +QQ +D +K D++E + NIQ ++ +K LEE NK
Sbjct: 772 VEDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKG 831
Query: 375 LMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINL-DE 433
LM EC LKE QYE+EK ER VV RQLQ+E D+L K +LE+ LE S INL DE
Sbjct: 832 LMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEISSERRINLEDE 891
Query: 434 TQVPKKKLFQVESQ 447
Q KKKL Q+ SQ
Sbjct: 892 AQSLKKKLGQMRSQ 905
Score = 66.6 bits (161), Expect = 6e-11
Identities = 115/482 (23%), Positives = 207/482 (42%), Gaps = 86/482 (17%)
Query: 156 ALEEEQERCERSEKKQSQVKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTY- 214
++E+++ CER + K ++K NN + +K+ LSE + S + K++ +
Sbjct: 431 SIEDQKCYCERLKVKFQKMK--NNISVLQKV-LSETDKTKSQSEHQNLQGKKKLCNLRFI 487
Query: 215 -PQQFPKKLKKEH----DREELERKEKQYKKEVEAK-QLEPTVQSLDMKLKTTRNTPNQ- 267
QQ +++K E D EEL+ E+QY+ + E K Q + T++SL+++LKT R+ NQ
Sbjct: 488 LQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQN 547
Query: 268 ---------INQSLRYSQKKVIGFRNSPNDLSQTQQQ--------IKEMKEMYENAEAKV 310
+ Q + ++ R + + Q+ I+ +KE E+ E +
Sbjct: 548 FHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTL 607
Query: 311 NNS----TGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFI------- 359
+ T + + + L EN + +L Q E R +
Sbjct: 608 KRNEETLTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDH 667
Query: 360 ---ESGKKDLMLEEKNKKLMNECDHLKES------LFQYEREKAERVV--VVRQLQQEAA 408
+S K+DL L ++ +NE HL+E + + KAE + +L E
Sbjct: 668 DQRQSSKRDLQLAFQST--VNEWCHLQEDTNSHIQILSQQLSKAESTSSGLETELHYER- 724
Query: 409 DSLKKLTM-----------LESPLEGISHYHIN---LDETQVPKKK-----LFQVESQFD 449
++LK+ T+ + LE I H + N + E V K++ LFQ++SQ
Sbjct: 725 EALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNL 784
Query: 450 DFMAEKEAVSSKCVNLAKEIQVFQQELL-SMKKVQQECEKLEEDKKMLEEEILNLKTHM- 507
+ + K N K I Q + +++K+Q EC KLEE+ K L +E LK
Sbjct: 785 LYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQC 844
Query: 508 -------ENSMVELSKLQEYKSELDER----AMQAVEKLEEIHLQEQAEH-KKQLEQLNK 555
E +V +E L+++ AM + I+L+++A+ KK+L Q+
Sbjct: 845 QYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEISSERRINLEDEAQSLKKKLGQMRS 904
Query: 556 DI 557
+
Sbjct: 905 QV 906
Score = 60.5 bits (145), Expect = 4e-09
Identities = 100/475 (21%), Positives = 180/475 (37%), Gaps = 81/475 (17%)
Query: 136 KGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNTNKSEKIQLSENVCHS 195
K +RK++Q +EQ L + E EQER E E Q QV+E +++K+++S NV
Sbjct: 260 KANKRRKSLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRNVHAD 319
Query: 196 TS---SAAADRLTKQRKVGKTYPQQFPKKLKKEHDREELERKEKQYKKEVEAK------- 245
S + D L + K K Q P K E DR L RK K +V+++
Sbjct: 320 DSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDR--LARKTSNEKSKVKSQIYFTDDL 377
Query: 246 -----QLEPTVQ---------------------------SLDMKLKTTRNTPNQINQSLR 273
E T + SL T I
Sbjct: 378 NDISGSSEKTSEDDELPYSDDENFMLLIKQSGMECKDFVSLSKSKNATAACGRSIEDQKC 437
Query: 274 YSQKKVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPC 333
Y ++ + F+ N++S Q+ + E + +E + N GK R Q E
Sbjct: 438 YCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQ--NLQGKKKLCNLRFILQQQEEER 495
Query: 334 I------EQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLF 387
I E+ ++++ E+ T +++ + L L+ +L + ++
Sbjct: 496 IKAEELYEKDIEELKIMEEQYRTQTEVKK------QSKLTLKSLEVELKTVRSNSNQNFH 549
Query: 388 QYEREKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQ 447
+ERE R L QE ++ L ++ I H + ET+ K ++ +
Sbjct: 550 THERE--------RDLWQENHLMRDEIARLRLEIDTIKHQN---QETENKYFKDIEIIKE 598
Query: 448 FDDFMAE-----KEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILN 502
++ + + +E ++ +KE+ V E + E +K ++ LE E+ +
Sbjct: 599 NNEDLEKTLKRNEETLTKTITRYSKELNVLMDE---NTMLNSELQKEKQSMSRLETEMES 655
Query: 503 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQL--EQLNK 555
+ + ++ + + Q K +L V E HLQE Q+ +QL+K
Sbjct: 656 YRCRLAAALCDHDQRQSSKRDLQLAFQSTVN--EWCHLQEDTNSHIQILSQQLSK 708
>gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo
sapiens]
Length = 917
Score = 116 bits (290), Expect = 6e-26
Identities = 95/314 (30%), Positives = 159/314 (50%), Gaps = 27/314 (8%)
Query: 157 LEEEQERCERSEKKQSQVKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVG---KT 213
++E E E++ K+ + T S+++ NV ++ L K+++ +T
Sbjct: 596 IKENNEDLEKTLKRNEEALTKTITRYSKEL----NVLMDENTMLNSELQKEKQSMSRLET 651
Query: 214 YPQQFPKKLKK---EHDREELERKEKQYKKEVEAKQL----EPT---VQSLDMKLKTTRN 263
+ + +L +HD+ + +++ Q + + E T +Q L +L +
Sbjct: 652 EMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAES 711
Query: 264 TPNQINQSLRYSQK----KVIGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSC 319
T + + L Y ++ K + + LS+TQ+++++++ MY+N + + K
Sbjct: 712 TSSGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQS 771
Query: 320 VEERICQLQHENPCIEQQLDDVHQKEDHKE-IVTNIQRGFIESGKK----DLMLEEKNKK 374
VE+ + QLQ +N +QQ +D +K D++E + NIQ ++ +K LEE NK
Sbjct: 772 VEDGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKG 831
Query: 375 LMNECDHLKESLFQYEREKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINL-DE 433
LM EC LKE QYE+EK ER VV RQLQ+E D+L K +LE+ LE S INL DE
Sbjct: 832 LMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEISSERRINLEDE 891
Query: 434 TQVPKKKLFQVESQ 447
Q KKKL Q+ SQ
Sbjct: 892 AQSLKKKLGQMRSQ 905
Score = 66.6 bits (161), Expect = 6e-11
Identities = 115/482 (23%), Positives = 207/482 (42%), Gaps = 86/482 (17%)
Query: 156 ALEEEQERCERSEKKQSQVKEGNNTNKSEKIQLSENVCHSTSSAAADRLTKQRKVGKTY- 214
++E+++ CER + K ++K NN + +K+ LSE + S + K++ +
Sbjct: 431 SIEDQKCYCERLKVKFQKMK--NNISVLQKV-LSETDKTKSQSEHQNLQGKKKLCNLRFI 487
Query: 215 -PQQFPKKLKKEH----DREELERKEKQYKKEVEAK-QLEPTVQSLDMKLKTTRNTPNQ- 267
QQ +++K E D EEL+ E+QY+ + E K Q + T++SL+++LKT R+ NQ
Sbjct: 488 LQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQN 547
Query: 268 ---------INQSLRYSQKKVIGFRNSPNDLSQTQQQ--------IKEMKEMYENAEAKV 310
+ Q + ++ R + + Q+ I+ +KE E+ E +
Sbjct: 548 FHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTL 607
Query: 311 NNS----TGKWSCVEERICQLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFI------- 359
+ T + + + L EN + +L Q E R +
Sbjct: 608 KRNEEALTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDH 667
Query: 360 ---ESGKKDLMLEEKNKKLMNECDHLKES------LFQYEREKAERVV--VVRQLQQEAA 408
+S K+DL L ++ +NE HL+E + + KAE + +L E
Sbjct: 668 DQRQSSKRDLQLAFQST--VNEWCHLQEDTNSHIQILSQQLSKAESTSSGLETELHYER- 724
Query: 409 DSLKKLTM-----------LESPLEGISHYHIN---LDETQVPKKK-----LFQVESQFD 449
++LK+ T+ + LE I H + N + E V K++ LFQ++SQ
Sbjct: 725 EALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNL 784
Query: 450 DFMAEKEAVSSKCVNLAKEIQVFQQELL-SMKKVQQECEKLEEDKKMLEEEILNLKTHM- 507
+ + K N K I Q + +++K+Q EC KLEE+ K L +E LK
Sbjct: 785 LYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQC 844
Query: 508 -------ENSMVELSKLQEYKSELDER----AMQAVEKLEEIHLQEQAEH-KKQLEQLNK 555
E +V +E L+++ AM + I+L+++A+ KK+L Q+
Sbjct: 845 QYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEISSERRINLEDEAQSLKKKLGQMRS 904
Query: 556 DI 557
+
Sbjct: 905 QV 906
Score = 59.3 bits (142), Expect = 9e-09
Identities = 99/469 (21%), Positives = 178/469 (37%), Gaps = 81/469 (17%)
Query: 142 KNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEGNNTNKSEKIQLSENVCHSTS---S 198
K++Q +EQ L + E EQER E E Q QV+E +++K+++S NV S +
Sbjct: 266 KSLQNSNSEQDLEMTSEGEQERLEGCESSQPQVEEKMKKCRNKKMEVSRNVHADDSDNYN 325
Query: 199 AAADRLTKQRKVGKTYPQQFPKKLKKEHDREELERKEKQYKKEVEAK------------Q 246
D L + K K Q P K E DR L RK K +V+++
Sbjct: 326 DDVDELIHKIKNRKPDNHQSPGKENGEFDR--LARKTSNEKSKVKSQIYFTDDLNDISGS 383
Query: 247 LEPTVQ---------------------------SLDMKLKTTRNTPNQINQSLRYSQKKV 279
E T + SL T I Y ++
Sbjct: 384 SEKTSEDDELPYSDDENFMLLIEQSGMECKDFVSLSKSKNATAACGRSIEDQKCYCERLK 443
Query: 280 IGFRNSPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCI----- 334
+ F+ N++S Q+ + E + +E + N GK R Q E I
Sbjct: 444 VKFQKMKNNISVLQKVLSETDKTKSQSEHQ--NLQGKKKLCNLRFILQQQEEERIKAEEL 501
Query: 335 -EQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYEREK 393
E+ ++++ E+ T +++ + L L+ +L + ++ +ERE
Sbjct: 502 YEKDIEELKIMEEQYRTQTEVKK------QSKLTLKSLEVELKTVRSNSNQNFHTHERE- 554
Query: 394 AERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDDFMA 453
R L QE ++ L ++ I H + ET+ K ++ + ++ +
Sbjct: 555 -------RDLWQENHLMRDEIARLRLEIDTIKHQN---QETENKYFKDIEIIKENNEDLE 604
Query: 454 E-----KEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHME 508
+ +EA++ +KE+ V E + E +K ++ LE E+ + + +
Sbjct: 605 KTLKRNEEALTKTITRYSKELNVLMDE---NTMLNSELQKEKQSMSRLETEMESYRCRLA 661
Query: 509 NSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQL--EQLNK 555
++ + + Q K +L V E HLQE Q+ +QL+K
Sbjct: 662 AALCDHDQRQSSKRDLQLAFQSTVN--EWCHLQEDTNSHIQILSQQLSK 708
>gi|169169660 PREDICTED: hypothetical protein [Homo sapiens]
Length = 460
Score = 99.8 bits (247), Expect = 6e-21
Identities = 52/90 (57%), Positives = 70/90 (77%), Gaps = 1/90 (1%)
Query: 461 KCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLKTHMENSMVELSKLQEY 520
KC+ LAK+ QV QQELLSMK+VQQ+C+KLEE K+LE+E++NLKTH E +MVE ++E
Sbjct: 335 KCLYLAKKNQVIQQELLSMKEVQQKCKKLEEVNKILEQEVVNLKTH-EKNMVEFGDVEEC 393
Query: 521 KSELDERAMQAVEKLEEIHLQEQAEHKKQL 550
K +L+ERA Q +EKLEEI+LQ K++
Sbjct: 394 KLQLEERAGQEIEKLEEINLQRACLSAKKV 423
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.333
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,475,066
Number of Sequences: 37866
Number of extensions: 987439
Number of successful extensions: 12415
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 307
Number of HSP's successfully gapped in prelim test: 1010
Number of HSP's that attempted gapping in prelim test: 6139
Number of HSP's gapped (non-prelim): 4286
length of query: 561
length of database: 18,247,518
effective HSP length: 107
effective length of query: 454
effective length of database: 14,195,856
effective search space: 6444918624
effective search space used: 6444918624
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.