Guide to the Human Genome
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Search of human proteins with 239741053

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239741053 PREDICTED: similar to Putative PRAME family member
24 [Homo sapiens]
         (474 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239741053 PREDICTED: similar to Putative PRAME family member ...   956   0.0  
gi|59676587 PRAME family member 8 [Homo sapiens]                      955   0.0  
gi|59676593 PRAME family member 7 [Homo sapiens]                      954   0.0  
gi|124249372 PRAME family member 12 [Homo sapiens]                    802   0.0  
gi|61696142 PRAME family member 5 [Homo sapiens]                      585   e-167
gi|58219004 PRAME family member 6 [Homo sapiens]                      585   e-167
gi|239741045 PREDICTED: PRAME family member 23 [Homo sapiens]         580   e-166
gi|148356236 PRAME family member 15 [Homo sapiens]                    575   e-164
gi|61102721 PRAME family member 9 [Homo sapiens]                      575   e-164
gi|153792112 PRAME family member 20 [Homo sapiens]                    566   e-161
gi|153945800 PRAME family member 21 [Homo sapiens]                    566   e-161
gi|239741043 PREDICTED: PRAME family member 11 [Homo sapiens]         565   e-161
gi|59958373 PRAME family member 4 [Homo sapiens]                      564   e-161
gi|239741047 PREDICTED: PRAME family member 25-like [Homo sapiens]    523   e-148
gi|226437621 PRAME family member 11 [Homo sapiens]                    507   e-143
gi|46249373 preferentially expressed antigen in melanoma [Homo s...   454   e-128
gi|46249371 preferentially expressed antigen in melanoma [Homo s...   454   e-128
gi|46249369 preferentially expressed antigen in melanoma [Homo s...   454   e-128
gi|46249367 preferentially expressed antigen in melanoma [Homo s...   454   e-128
gi|5174641 preferentially expressed antigen in melanoma [Homo sa...   454   e-128
gi|12738831 PRAME family member 1 [Homo sapiens]                      450   e-126
gi|153791443 PRAME family member 18 [Homo sapiens]                    448   e-126
gi|66954681 PRAME family member 13 [Homo sapiens]                     448   e-126
gi|194018546 PRAME family member 10 [Homo sapiens]                    446   e-125
gi|194306635 PRAME family member 19 [Homo sapiens]                    445   e-125
gi|154800493 PRAME family member 22 [Homo sapiens]                    441   e-124
gi|194306638 PRAME family member 3 [Homo sapiens]                     441   e-124
gi|157426839 PRAME family member 17 [Homo sapiens]                    440   e-123
gi|113865933 PRAME family member 16 [Homo sapiens]                    438   e-123
gi|12738834 PRAME family member 2 [Homo sapiens]                      437   e-122

>gi|239741053 PREDICTED: similar to Putative PRAME family member 24
           [Homo sapiens]
          Length = 474

 Score =  956 bits (2472), Expect = 0.0
 Identities = 474/474 (100%), Positives = 474/474 (100%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP
Sbjct: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT
Sbjct: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120

Query: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180
           ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC
Sbjct: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180

Query: 181 KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNI 240
           KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNI
Sbjct: 181 KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNI 240

Query: 241 RASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT 300
           RASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT
Sbjct: 241 RASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT 300

Query: 301 DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGI 360
           DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGI
Sbjct: 301 DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGI 360

Query: 361 MDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDT 420
           MDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDT
Sbjct: 361 MDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDT 420

Query: 421 QGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
           QGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC
Sbjct: 421 QGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474


>gi|59676587 PRAME family member 8 [Homo sapiens]
          Length = 474

 Score =  955 bits (2468), Expect = 0.0
 Identities = 473/474 (99%), Positives = 474/474 (100%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP
Sbjct: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT
Sbjct: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120

Query: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180
           ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC
Sbjct: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180

Query: 181 KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNI 240
           +ELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNI
Sbjct: 181 QELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNI 240

Query: 241 RASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT 300
           RASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT
Sbjct: 241 RASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT 300

Query: 301 DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGI 360
           DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGI
Sbjct: 301 DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGI 360

Query: 361 MDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDT 420
           MDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDT
Sbjct: 361 MDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDT 420

Query: 421 QGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
           QGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC
Sbjct: 421 QGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474


>gi|59676593 PRAME family member 7 [Homo sapiens]
          Length = 474

 Score =  954 bits (2465), Expect = 0.0
 Identities = 473/474 (99%), Positives = 473/474 (99%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP
Sbjct: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT
Sbjct: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120

Query: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180
           ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC
Sbjct: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180

Query: 181 KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNI 240
           KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNI
Sbjct: 181 KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNI 240

Query: 241 RASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT 300
           RASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT
Sbjct: 241 RASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT 300

Query: 301 DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGI 360
           DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGI
Sbjct: 301 DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGI 360

Query: 361 MDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDT 420
           MDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDT
Sbjct: 361 MDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDT 420

Query: 421 QGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
           QGALCWGRFAELGAELMKT RDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC
Sbjct: 421 QGALCWGRFAELGAELMKTPRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474


>gi|124249372 PRAME family member 12 [Homo sapiens]
          Length = 483

 Score =  802 bits (2071), Expect = 0.0
 Identities = 397/473 (83%), Positives = 426/473 (90%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MS++APPRLLELA Q LLRD+ALAI T+EELPRELFP LFMEAF+RR CETL TMVQAWP
Sbjct: 1   MSLQAPPRLLELAEQSLLRDRALAIPTLEELPRELFPPLFMEAFTRRCCETLTTMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           FT LPLGSLMKS +LE  ++VLEG+D LL Q+VRPR+ KLQVLDLRNVDENF  I+SGA+
Sbjct: 61  FTCLPLGSLMKSCNLEIFRAVLEGLDALLAQKVRPRRWKLQVLDLRNVDENFWGIWSGAS 120

Query: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180
           A  PEALS+++TA NCP  G QQP MV +DLC KN  LDECLTH LEWGKQRKGLLHVCC
Sbjct: 121 ALSPEALSKRRTAGNCPRPGGQQPLMVILDLCFKNGMLDECLTHFLEWGKQRKGLLHVCC 180

Query: 181 KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNI 240
           KELQ+FG+ IH IIEVLN VELDCIQEVEVCCPWELS L++FAPYLGQMRNLRKLVLFNI
Sbjct: 181 KELQIFGIAIHRIIEVLNTVELDCIQEVEVCCPWELSILIRFAPYLGQMRNLRKLVLFNI 240

Query: 241 RASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT 300
             SACIP D K QF+ +FTSQFLKLDYFQ L MHSVSFLEGHLDQLLRCLQA LE VVMT
Sbjct: 241 HVSACIPLDRKEQFVIQFTSQFLKLDYFQKLYMHSVSFLEGHLDQLLRCLQAPLETVVMT 300

Query: 301 DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGI 360
           +CLLSESDLKHLSWCPSIRQLKELDLRG+TLTHFSPEPL+ LLEQ  ATLQTLDLEDCGI
Sbjct: 301 ECLLSESDLKHLSWCPSIRQLKELDLRGITLTHFSPEPLSVLLEQAEATLQTLDLEDCGI 360

Query: 361 MDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDT 420
           +DSQLSAILP LSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYD 
Sbjct: 361 VDSQLSAILPALSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDA 420

Query: 421 QGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCL 473
           QGALCWGRF++LGAELMKTLRDLRQPKIIVF TVPCPRCGIRASYDLEPSHCL
Sbjct: 421 QGALCWGRFSQLGAELMKTLRDLRQPKIIVFSTVPCPRCGIRASYDLEPSHCL 473


>gi|61696142 PRAME family member 5 [Homo sapiens]
          Length = 476

 Score =  585 bits (1509), Expect = e-167
 Identities = 300/476 (63%), Positives = 360/476 (75%), Gaps = 2/476 (0%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIR PPRLLELA + LLRDQALA+ST+EELP ELFP LFMEAFSRRRCE LK MVQAWP
Sbjct: 1   MSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPL  L+K P LE+ ++VL+G+D LLTQ V PR+ KLQVLDL++V ENF  ++S A 
Sbjct: 61  FRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVWSEAM 120

Query: 121 AS--FPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A   F  A   K+   +CP    QQP  VF++L LKNRTLDE LT LL W KQRK LLH+
Sbjct: 121 AHGCFLNAKRNKKPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CCK+L++ GMP  +I  +L MV LDCIQEVEV C W L  L +F PYLG MRNL+KLVL 
Sbjct: 181 CCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLVLS 240

Query: 239 NIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVV 298
           ++  S  + P+ K + + +FT+QFLKL   Q LSM+SVSFLEGHLDQLL CL+ SL+++ 
Sbjct: 241 HMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSLKVLT 300

Query: 299 MTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDC 358
           +T+C+L ESDLKHLS CPSI QLK LDL G+ LT++S  PL  LLE+V ATL+ LDL+DC
Sbjct: 301 ITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDC 360

Query: 359 GIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESY 418
           GI+DSQ++AILP LSRC +L+TFSFCGN ISMA LENLL HT+ L  L +ELYPAP ESY
Sbjct: 361 GIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYPAPRESY 420

Query: 419 DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
           D  G LCW RFA++ AELMK +RDLR PK I+FCT  CP CG R+ YDLE   C C
Sbjct: 421 DADGTLCWSRFAQIRAELMKRVRDLRHPKRILFCTDCCPDCGNRSFYDLEADQCCC 476


>gi|58219004 PRAME family member 6 [Homo sapiens]
          Length = 476

 Score =  585 bits (1507), Expect = e-167
 Identities = 300/476 (63%), Positives = 359/476 (75%), Gaps = 2/476 (0%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIR PPRLLELA + LLRDQALA+ST+EELP ELFP LFMEAFSRRRCE LK MVQAWP
Sbjct: 1   MSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPL  L+K P LE+ ++VL+G+D LLTQ V PR+ KLQVLDL++V ENF  ++S A 
Sbjct: 61  FRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVWSEAM 120

Query: 121 AS--FPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A   F  A   K    +CP    QQP  VF++L LKNRTLDE LT LL W KQRK LLH+
Sbjct: 121 ARGCFLNAKRNKTPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CCK+L++ GMP  +I  +L MV LDCIQEVEV C W L  L +F PYLG MRNL+KLVL 
Sbjct: 181 CCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLVLS 240

Query: 239 NIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVV 298
           ++  S  + P+ K + + +FT+QFLKL   Q LSM+SVSFLEGHLDQLL CL+ SL+++ 
Sbjct: 241 HMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSLKVLT 300

Query: 299 MTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDC 358
           +T+C+L ESDLKHLS CPSI QLK LDL G+ LT++S  PL  LLE+V ATL+ LDL+DC
Sbjct: 301 ITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDC 360

Query: 359 GIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESY 418
           GI+DSQ++AILP LSRC +L+TFSFCGN ISMA LENLL HT+ L  L +ELYPAP ESY
Sbjct: 361 GIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYPAPRESY 420

Query: 419 DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
           D  G LCW RFA++ AELMK +RDLR PK I+FCT  CP CG R+ YDLE   C C
Sbjct: 421 DADGTLCWSRFAQIRAELMKRVRDLRHPKRILFCTDCCPDCGNRSFYDLEADQCCC 476


>gi|239741045 PREDICTED: PRAME family member 23 [Homo sapiens]
          Length = 476

 Score =  580 bits (1496), Expect = e-166
 Identities = 298/476 (62%), Positives = 358/476 (75%), Gaps = 2/476 (0%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIR PPRLLELA + LLRDQALA+ST+EELP ELFP LFMEAFSRRRCE LK MVQAWP
Sbjct: 1   MSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPL  L+K P LE+ ++VL+G+D LLTQ V PR+ KLQVLDL++V ENF  ++S A 
Sbjct: 61  FRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVWSEAM 120

Query: 121 AS--FPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A   F  A   K+   +CP    QQP  VF++L LKNRTLDE LT LL W KQRK LLH+
Sbjct: 121 AHGCFLNAKRNKKPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CCK+L++ GMP  +I  +L MV LDCIQEVEV C W L  L +F PYLG MRNL+KLVL 
Sbjct: 181 CCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLVLS 240

Query: 239 NIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVV 298
           ++  S  + P+ K + + +FT+QFLKL   Q LSM+SVSFLEGHLDQLL CL+ SL+++ 
Sbjct: 241 HMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSLKVLT 300

Query: 299 MTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDC 358
           +T+C+L ESDLKHLS CPSI QLK LDL G+ LT++S  PL  LLE+V ATL+ LDL+DC
Sbjct: 301 ITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDC 360

Query: 359 GIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESY 418
           GI+DSQ++AILP LS C +L+TFSFCGN ISMA LENLL HT+ L  L +ELYPAP ESY
Sbjct: 361 GIIDSQVNAILPALSCCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYPAPRESY 420

Query: 419 DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
           D  G LCW RF ++ AELMK +RDLR PK I+FCT  CP CG R+ YDLE   C C
Sbjct: 421 DADGTLCWSRFPQIRAELMKRVRDLRHPKRILFCTDCCPDCGNRSFYDLEADQCCC 476


>gi|148356236 PRAME family member 15 [Homo sapiens]
          Length = 478

 Score =  575 bits (1482), Expect = e-164
 Identities = 295/476 (61%), Positives = 357/476 (75%), Gaps = 2/476 (0%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIR PPRLLELA + LLRDQALA+ST+EELP ELFP LFMEAFSRRRCE LK MVQAWP
Sbjct: 3   MSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWP 62

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPL  L+K P LE+ ++VL+G+D LLTQ VRPR+ KLQVLDL++V ENF  ++S A 
Sbjct: 63  FRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDVCENFWMVWSEAM 122

Query: 121 AS--FPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A   F  A   K+   +CP    +QP  VF++L LKNRTLDE LT+LL W KQRK LLH+
Sbjct: 123 AHGCFLNAKRNKKPVQDCPRMRGRQPLTVFVELWLKNRTLDEYLTYLLLWVKQRKDLLHL 182

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CCK+L++ GMP  +I  +L MV LDCIQEVEV C W L  L +F PYLG MRNL+KLVL 
Sbjct: 183 CCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLVLS 242

Query: 239 NIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVV 298
           ++  S  + P+ K + + +FT+QFLKL   Q L M+SVSFLEGHLDQLL CL+ SL+++ 
Sbjct: 243 HMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLLSCLKTSLKVLT 302

Query: 299 MTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDC 358
           +T+C+L ESDLKHLS CPSI QLK LDL G+ LT++S  PL  LLE+V ATL+ LDL+DC
Sbjct: 303 ITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDC 362

Query: 359 GIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESY 418
           GI+DSQ++AILP LSRC +L+TFSFCGN I MA LENLL HT+ L  L +ELYPAP ESY
Sbjct: 363 GIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLCVELYPAPRESY 422

Query: 419 DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
              G LCW RFA++ AELM  +RDLR PK I+FCT  CP CG R+ YDLE     C
Sbjct: 423 GADGTLCWSRFAQIRAELMNRVRDLRHPKRILFCTDYCPDCGNRSFYDLEADQYCC 478


>gi|61102721 PRAME family member 9 [Homo sapiens]
          Length = 478

 Score =  575 bits (1482), Expect = e-164
 Identities = 295/476 (61%), Positives = 357/476 (75%), Gaps = 2/476 (0%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIR PPRLLELA + LLRDQALA+ST+EELP ELFP LFMEAFSRRRCE LK MVQAWP
Sbjct: 3   MSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWP 62

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPL  L+K P LE+ ++VL+G+D LLTQ VRPR+ KLQVLDL++V ENF  ++S A 
Sbjct: 63  FRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDVCENFWMVWSEAM 122

Query: 121 AS--FPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A   F  A   K+   +CP    +QP  VF++L LKNRTLDE LT+LL W KQRK LLH+
Sbjct: 123 AHGCFLNAKRNKKPVQDCPRMRGRQPLTVFVELWLKNRTLDEYLTYLLLWVKQRKDLLHL 182

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CCK+L++ GMP  +I  +L MV LDCIQEVEV C W L  L +F PYLG MRNL+KLVL 
Sbjct: 183 CCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLVLS 242

Query: 239 NIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVV 298
           ++  S  + P+ K + + +FT+QFLKL   Q L M+SVSFLEGHLDQLL CL+ SL+++ 
Sbjct: 243 HMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLLSCLKTSLKVLT 302

Query: 299 MTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDC 358
           +T+C+L ESDLKHLS CPSI QLK LDL G+ LT++S  PL  LLE+V ATL+ LDL+DC
Sbjct: 303 ITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDC 362

Query: 359 GIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESY 418
           GI+DSQ++AILP LSRC +L+TFSFCGN I MA LENLL HT+ L  L +ELYPAP ESY
Sbjct: 363 GIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLCVELYPAPRESY 422

Query: 419 DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
              G LCW RFA++ AELM  +RDLR PK I+FCT  CP CG R+ YDLE     C
Sbjct: 423 GADGTLCWSRFAQIRAELMNRVRDLRHPKRILFCTDYCPDCGNRSFYDLEADQYCC 478


>gi|153792112 PRAME family member 20 [Homo sapiens]
          Length = 475

 Score =  566 bits (1459), Expect = e-161
 Identities = 296/476 (62%), Positives = 356/476 (74%), Gaps = 3/476 (0%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIR PPRLLELA + LLRD+ALAIST+EELP ELFP LFMEAFSRR CE LK MVQAWP
Sbjct: 1   MSIRTPPRLLELAGRSLLRDEALAISTLEELPTELFPPLFMEAFSRRHCEALKLMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPLGSLMK P  E+ ++VL+G+D LLT  VR R+ KLQVLDL++V ENF  ++S A 
Sbjct: 61  FLRLPLGSLMKRPCPETFQAVLDGLDALLTHRVRLRRWKLQVLDLQDVSENFWMVWSEAM 120

Query: 121 AS--FPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A    P A+  ++   +CP    QQP  VFIDLCLKNRTLDE  T L  W KQR+GL+H+
Sbjct: 121 ARRCLPNAMMNRKPVQDCPRMRGQQPLTVFIDLCLKNRTLDEYFTCLFLWVKQREGLVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CCK+L++ GM  H+I  +L  V LDCIQEVEV C W L  L +F PYLGQMRNLRKLVL 
Sbjct: 181 CCKKLKMLGMLFHNIRNILKTVNLDCIQEVEVNCNWTLPVLAEFTPYLGQMRNLRKLVLS 240

Query: 239 NIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVV 298
           +I  S  I P+ K +F+ +FT+QFLKL   Q L M+SVSFLEGHLDQ+L CL+ SL ++ 
Sbjct: 241 DID-SRYISPEQKKEFVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQMLSCLKTSLNILA 299

Query: 299 MTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDC 358
           +T+C+L ESDLKHLS  PSI QLK LDL G  L +FS  PL  LLE+V ATL+ LDL+DC
Sbjct: 300 ITNCVLLESDLKHLSKYPSIGQLKTLDLSGTRLANFSLVPLQVLLEKVAATLEYLDLDDC 359

Query: 359 GIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESY 418
           GI+DSQ++AILP LSRC +L+TFSF GN IS A LENLL HT+ L+ L LELYPAP ESY
Sbjct: 360 GIVDSQVNAILPALSRCFELTTFSFRGNPISTATLENLLCHTIRLNNLCLELYPAPRESY 419

Query: 419 DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
           D +G +C  RFA+LGAELM  +R LR+P+ I+FCT  CP+CG R+ YDLE   C C
Sbjct: 420 DVRGIVCRSRFAQLGAELMGRVRALREPERILFCTDYCPQCGNRSLYDLEVDRCCC 475


>gi|153945800 PRAME family member 21 [Homo sapiens]
          Length = 475

 Score =  566 bits (1459), Expect = e-161
 Identities = 296/476 (62%), Positives = 356/476 (74%), Gaps = 3/476 (0%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIR PPRLLELA + LLRD+ALAIST+EELP ELFP LFMEAFSRR CE LK MVQAWP
Sbjct: 1   MSIRTPPRLLELAGRSLLRDEALAISTLEELPTELFPPLFMEAFSRRHCEALKLMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPLGSLMK P  E+ ++VL+G+D LLT  VR R+ KLQVLDL++V ENF  ++S A 
Sbjct: 61  FLRLPLGSLMKRPCPETFQAVLDGLDALLTHRVRLRRWKLQVLDLQDVSENFWMVWSEAM 120

Query: 121 AS--FPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A    P A+  ++   +CP    QQP  VFIDLCLKNRTLDE  T L  W KQR+GL+H+
Sbjct: 121 ARRCLPNAMMNRKPVQDCPRMRGQQPLTVFIDLCLKNRTLDEYFTCLFLWVKQREGLVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CCK+L++ GM  H+I  +L  V LDCIQEVEV C W L  L +F PYLGQMRNLRKLVL 
Sbjct: 181 CCKKLKMLGMLFHNIRNILKTVNLDCIQEVEVNCNWTLPVLAEFTPYLGQMRNLRKLVLS 240

Query: 239 NIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVV 298
           +I  S  I P+ K +F+ +FT+QFLKL   Q L M+SVSFLEGHLDQ+L CL+ SL ++ 
Sbjct: 241 DID-SRYISPEQKKEFVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQMLSCLKTSLNILA 299

Query: 299 MTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDC 358
           +T+C+L ESDLKHLS  PSI QLK LDL G  L +FS  PL  LLE+V ATL+ LDL+DC
Sbjct: 300 ITNCVLLESDLKHLSKYPSIGQLKTLDLSGTRLANFSLVPLQVLLEKVAATLEYLDLDDC 359

Query: 359 GIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESY 418
           GI+DSQ++AILP LSRC +L+TFSF GN IS A LENLL HT+ L+ L LELYPAP ESY
Sbjct: 360 GIVDSQVNAILPALSRCFELTTFSFRGNPISTATLENLLCHTIRLNNLCLELYPAPRESY 419

Query: 419 DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
           D +G +C  RFA+LGAELM  +R LR+P+ I+FCT  CP+CG R+ YDLE   C C
Sbjct: 420 DVRGIVCRSRFAQLGAELMGRVRALREPERILFCTDYCPQCGNRSLYDLEVDRCCC 475


>gi|239741043 PREDICTED: PRAME family member 11 [Homo sapiens]
          Length = 513

 Score =  565 bits (1456), Expect = e-161
 Identities = 292/476 (61%), Positives = 353/476 (74%), Gaps = 2/476 (0%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSIR PPRLLEL  + LLRDQALA+ST+EELP ELFP LFMEAFSRRRCE LK MVQAWP
Sbjct: 38  MSIRIPPRLLELXGRSLLRDQALAVSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWP 97

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPL  L+K P LE+ ++VL+G+D LLTQ VRPR+ KLQVLDL++V ENF  ++S A 
Sbjct: 98  FRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDVCENFWMVWSEAM 157

Query: 121 AS--FPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A   F  A   K    +CP    +QP  VF++L LKNRTLDE LT LL W KQR+ LLH+
Sbjct: 158 AHGCFLNAKRNKTPVQDCPRMRERQPLTVFVELWLKNRTLDEYLTCLLLWVKQRRDLLHL 217

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CCK+L++ GMP  +I  +L MV LDCIQEVEV C W L  L +F PYLG +RNL+KLVL 
Sbjct: 218 CCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWILPILTQFTPYLGHLRNLQKLVLS 277

Query: 239 NIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVV 298
           ++  S  + P+ K + + +FT+QFLKL   Q L M+SVSFLEGHLDQLL CL+ SL+++ 
Sbjct: 278 HMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLLSCLKTSLKVLT 337

Query: 299 MTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDC 358
           +T+C+L ESDLKHLS CPSI QLK LDL G+ LT++S  PL  LLE+V ATL+ LDL+DC
Sbjct: 338 ITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDC 397

Query: 359 GIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESY 418
           GI+DSQ++AILP LSRC +L+TFSFCGN I MA LENLL HT+ L  L LELYPAP ESY
Sbjct: 398 GIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLCLELYPAPQESY 457

Query: 419 DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
              G LCW RFA++ AELMK +R LR PK I+FCT  CP  G R+ YDLE     C
Sbjct: 458 GADGTLCWSRFAQIRAELMKKVRHLRHPKRILFCTDNCPDHGDRSFYDLEADQYCC 513


>gi|59958373 PRAME family member 4 [Homo sapiens]
          Length = 478

 Score =  564 bits (1454), Expect = e-161
 Identities = 290/476 (60%), Positives = 353/476 (74%), Gaps = 2/476 (0%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSI  PPRLLELA + LLRDQALA+ST+EELP ELFP LFMEAFSRRRCE LK MVQ+WP
Sbjct: 3   MSIWTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQSWP 62

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPL  L+K P LE+ ++VL+G+D LL   VRPR+ KLQVLDL++V ENF  ++S A 
Sbjct: 63  FRRLPLRPLIKMPCLEAFQAVLDGLDALLNLGVRPRRWKLQVLDLQDVCENFWMVWSEAM 122

Query: 121 AS--FPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A   F  A   K+  ++CP    +QP  VF++L LKNRTLDE LT LL W KQRK LLH+
Sbjct: 123 AHGCFLNAKRNKKPVEDCPRMRGRQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHL 182

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CCK+L++ GMP  +I  +L MV LDCIQEVEV C W L  L +F PYLG MRNL+KL+L 
Sbjct: 183 CCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLILS 242

Query: 239 NIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVV 298
           ++  S  + P+ K + + +FT+QFLKL   Q L M+SVSFLEGHLDQLL CL+ SL+ + 
Sbjct: 243 HMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLLSCLKTSLKFLT 302

Query: 299 MTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDC 358
           +T+C+L ESDLKHLS CPSI QLK LDL G+ LT++S  PL  LLE+V ATL+ LDL+DC
Sbjct: 303 ITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDC 362

Query: 359 GIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESY 418
           GI+DSQ++AILP LSRC +L+TFSFCGN I MA LENLL HT+ L  L +ELYPAP ESY
Sbjct: 363 GIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLCVELYPAPRESY 422

Query: 419 DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
              G LCW RFA++ AELM  +RDLR PK I+FCT  CP CG R+ YDLE     C
Sbjct: 423 GADGTLCWSRFAQIRAELMNRVRDLRHPKRILFCTDYCPDCGNRSFYDLEADQYCC 478


>gi|239741047 PREDICTED: PRAME family member 25-like [Homo sapiens]
          Length = 474

 Score =  523 bits (1347), Expect = e-148
 Identities = 278/479 (58%), Positives = 350/479 (73%), Gaps = 10/479 (2%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MS++AP RLLELA Q LL DQALAIS ++ELPRELFP LF+EAF+ RRCE LK MVQAWP
Sbjct: 1   MSLQAPRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F  LPLGSLMK+P LE L  V++G+D LL Q+VRPR+ KLQVL+LR+VDENF  I+SGA 
Sbjct: 61  FPCLPLGSLMKTPDLEILHYVVDGIDCLLAQKVRPRRRKLQVLELRDVDENFWTIWSGAR 120

Query: 121 --ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
             +  PEA+S++QT ++CP TG +QP  VF+D+CLK + +DE L+    W + R+G +H+
Sbjct: 121 PLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRGSVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEV---CCPWELSTLVKFAPYLGQMRNLRKL 235
           CC ++  + M I +   +L  V  D IQ +E+   C P     +V+F+PYL QMRNLRKL
Sbjct: 181 CCTKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWP---CMIVEFSPYLSQMRNLRKL 237

Query: 236 VLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLE 295
            + +      +  D++ Q IA FT+QFLKL   Q L M+SVSFLEGHLDQLL CL+ SL+
Sbjct: 238 FISD-GCRYLLSSDSQEQ-IAPFTTQFLKLHCLQKLYMNSVSFLEGHLDQLLSCLKTSLK 295

Query: 296 MVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDL 355
           ++ +T+C+L ESDLKHLS CPSI QLK LDL G+ LT++S  PL  LLE+V ATL+ LDL
Sbjct: 296 VLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDL 355

Query: 356 EDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPL 415
           +DCGI+DSQ++AILP LSRC +L+TFSFCGN ISMA LENLL HT+ L  L LELYPAP 
Sbjct: 356 DDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCLELYPAPR 415

Query: 416 ESYDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC 474
           ESY   G LCW RF ++ AELMK +RDLR PK I+F T  CP CG R+ YDLE     C
Sbjct: 416 ESYGADGTLCWSRFTQIRAELMKRVRDLRHPKRILFGTDYCPDCGNRSFYDLEADQYCC 474


>gi|226437621 PRAME family member 11 [Homo sapiens]
          Length = 436

 Score =  507 bits (1305), Expect = e-143
 Identities = 261/436 (59%), Positives = 319/436 (73%), Gaps = 2/436 (0%)

Query: 41  MEAFSRRRCETLKTMVQAWPFTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKL 100
           MEAFSRRRCE LK MVQAWPF RLPL  L+K P LE+ ++VL+G+D LLTQ VRPR+ KL
Sbjct: 1   MEAFSRRRCEALKLMVQAWPFRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVRPRRWKL 60

Query: 101 QVLDLRNVDENFCDIFSGATAS--FPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTL 158
           QVLDL++V ENF  ++S A A   F  A   K    +CP    +QP  VF++L LKNRTL
Sbjct: 61  QVLDLQDVCENFWMVWSEAMAHGCFLNAKRNKTPVQDCPRMRERQPLTVFVELWLKNRTL 120

Query: 159 DECLTHLLEWGKQRKGLLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELST 218
           DE LT LL W KQR+ LLH+CCK+L++ GMP  +I  +L MV LDCIQEVEV C W L  
Sbjct: 121 DEYLTCLLLWVKQRRDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWILPI 180

Query: 219 LVKFAPYLGQMRNLRKLVLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSF 278
           L +F PYLG +RNL+KLVL ++  S  + P+ K + + +FT+QFLKL   Q L M+SVSF
Sbjct: 181 LTQFTPYLGHLRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSF 240

Query: 279 LEGHLDQLLRCLQASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEP 338
           LEGHLDQLL CL+ SL+++ +T+C+L ESDLKHLS CPSI QLK LDL G+ LT++S  P
Sbjct: 241 LEGHLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVP 300

Query: 339 LTGLLEQVVATLQTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLR 398
           L  LLE+V ATL+ LDL+DCGI+DSQ++AILP LSRC +L+TFSFCGN I MA LENLL 
Sbjct: 301 LQILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLS 360

Query: 399 HTVGLSKLSLELYPAPLESYDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPR 458
           HT+ L  L LELYPAP ESY   G LCW RFA++ AELMK +R LR PK I+FCT  CP 
Sbjct: 361 HTIILKNLCLELYPAPQESYGADGTLCWSRFAQIRAELMKKVRHLRHPKRILFCTDNCPD 420

Query: 459 CGIRASYDLEPSHCLC 474
            G R+ YDLE     C
Sbjct: 421 HGDRSFYDLEADQYCC 436


>gi|46249373 preferentially expressed antigen in melanoma [Homo
           sapiens]
          Length = 509

 Score =  454 bits (1168), Expect = e-128
 Identities = 255/485 (52%), Positives = 329/485 (67%), Gaps = 16/485 (3%)

Query: 5   APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64
           +P RL+ELA Q LL+D+ALAI+ +E LPRELFP LFM AF  R  +TLK MVQAWPFT L
Sbjct: 22  SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81

Query: 65  PLGSLMKSPHL--ESLKSVLEGVDVLLTQEVRPRQSKLQVLDLR-NVDENFCDIFSGATA 121
           PLG LMK  HL  E+ K+VL+G+DVLL QEVRPR+ KLQVLDLR N  ++F  ++SG  A
Sbjct: 82  PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141

Query: 122 S---FPEA-----LSQKQTADNCPGTGRQQPFM---VFIDLCLKNRTLDECLTHLLEWGK 170
           S   FPE      +++K+  D    T  +QPF+   V +DL LK    DE  ++L+E  K
Sbjct: 142 SLYSFPEPEAAQPMTKKRKVDGL-STEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVK 200

Query: 171 QRKGLLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMR 230
           ++K +L +CCK+L++F MP+  I  +L MV+LD I+++EV C W+L TL KF+PYLGQM 
Sbjct: 201 RKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSPYLGQMI 260

Query: 231 NLRKLVLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCL 290
           NLR+L+L +I AS+ I P+ + Q+IA+FTSQFL L   Q L + S+ FL G LDQLLR +
Sbjct: 261 NLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHV 320

Query: 291 QASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATL 350
              LE + +T+C LSE D+ HLS  PS+ QL  L L GV LT  SPEPL  LLE+  ATL
Sbjct: 321 MNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATL 380

Query: 351 QTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLEL 410
           Q L  ++CGI D QL A+LP LS CSQL+T SF GN IS++AL++LL+H +GLS L+  L
Sbjct: 381 QDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVL 440

Query: 411 YPAPLESY-DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEP 469
           YP PLESY D  G L   R A L A L + L +L +P ++     PCP CG R  YD EP
Sbjct: 441 YPVPLESYEDIHGTLHLERLAYLHARLRELLCELGRPSMVWLSANPCPHCGDRTFYDPEP 500

Query: 470 SHCLC 474
             C C
Sbjct: 501 ILCPC 505


>gi|46249371 preferentially expressed antigen in melanoma [Homo
           sapiens]
          Length = 509

 Score =  454 bits (1168), Expect = e-128
 Identities = 255/485 (52%), Positives = 329/485 (67%), Gaps = 16/485 (3%)

Query: 5   APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64
           +P RL+ELA Q LL+D+ALAI+ +E LPRELFP LFM AF  R  +TLK MVQAWPFT L
Sbjct: 22  SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81

Query: 65  PLGSLMKSPHL--ESLKSVLEGVDVLLTQEVRPRQSKLQVLDLR-NVDENFCDIFSGATA 121
           PLG LMK  HL  E+ K+VL+G+DVLL QEVRPR+ KLQVLDLR N  ++F  ++SG  A
Sbjct: 82  PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141

Query: 122 S---FPEA-----LSQKQTADNCPGTGRQQPFM---VFIDLCLKNRTLDECLTHLLEWGK 170
           S   FPE      +++K+  D    T  +QPF+   V +DL LK    DE  ++L+E  K
Sbjct: 142 SLYSFPEPEAAQPMTKKRKVDGL-STEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVK 200

Query: 171 QRKGLLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMR 230
           ++K +L +CCK+L++F MP+  I  +L MV+LD I+++EV C W+L TL KF+PYLGQM 
Sbjct: 201 RKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSPYLGQMI 260

Query: 231 NLRKLVLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCL 290
           NLR+L+L +I AS+ I P+ + Q+IA+FTSQFL L   Q L + S+ FL G LDQLLR +
Sbjct: 261 NLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHV 320

Query: 291 QASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATL 350
              LE + +T+C LSE D+ HLS  PS+ QL  L L GV LT  SPEPL  LLE+  ATL
Sbjct: 321 MNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATL 380

Query: 351 QTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLEL 410
           Q L  ++CGI D QL A+LP LS CSQL+T SF GN IS++AL++LL+H +GLS L+  L
Sbjct: 381 QDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVL 440

Query: 411 YPAPLESY-DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEP 469
           YP PLESY D  G L   R A L A L + L +L +P ++     PCP CG R  YD EP
Sbjct: 441 YPVPLESYEDIHGTLHLERLAYLHARLRELLCELGRPSMVWLSANPCPHCGDRTFYDPEP 500

Query: 470 SHCLC 474
             C C
Sbjct: 501 ILCPC 505


>gi|46249369 preferentially expressed antigen in melanoma [Homo
           sapiens]
          Length = 509

 Score =  454 bits (1168), Expect = e-128
 Identities = 255/485 (52%), Positives = 329/485 (67%), Gaps = 16/485 (3%)

Query: 5   APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64
           +P RL+ELA Q LL+D+ALAI+ +E LPRELFP LFM AF  R  +TLK MVQAWPFT L
Sbjct: 22  SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81

Query: 65  PLGSLMKSPHL--ESLKSVLEGVDVLLTQEVRPRQSKLQVLDLR-NVDENFCDIFSGATA 121
           PLG LMK  HL  E+ K+VL+G+DVLL QEVRPR+ KLQVLDLR N  ++F  ++SG  A
Sbjct: 82  PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141

Query: 122 S---FPEA-----LSQKQTADNCPGTGRQQPFM---VFIDLCLKNRTLDECLTHLLEWGK 170
           S   FPE      +++K+  D    T  +QPF+   V +DL LK    DE  ++L+E  K
Sbjct: 142 SLYSFPEPEAAQPMTKKRKVDGL-STEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVK 200

Query: 171 QRKGLLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMR 230
           ++K +L +CCK+L++F MP+  I  +L MV+LD I+++EV C W+L TL KF+PYLGQM 
Sbjct: 201 RKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSPYLGQMI 260

Query: 231 NLRKLVLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCL 290
           NLR+L+L +I AS+ I P+ + Q+IA+FTSQFL L   Q L + S+ FL G LDQLLR +
Sbjct: 261 NLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHV 320

Query: 291 QASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATL 350
              LE + +T+C LSE D+ HLS  PS+ QL  L L GV LT  SPEPL  LLE+  ATL
Sbjct: 321 MNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATL 380

Query: 351 QTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLEL 410
           Q L  ++CGI D QL A+LP LS CSQL+T SF GN IS++AL++LL+H +GLS L+  L
Sbjct: 381 QDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVL 440

Query: 411 YPAPLESY-DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEP 469
           YP PLESY D  G L   R A L A L + L +L +P ++     PCP CG R  YD EP
Sbjct: 441 YPVPLESYEDIHGTLHLERLAYLHARLRELLCELGRPSMVWLSANPCPHCGDRTFYDPEP 500

Query: 470 SHCLC 474
             C C
Sbjct: 501 ILCPC 505


>gi|46249367 preferentially expressed antigen in melanoma [Homo
           sapiens]
          Length = 509

 Score =  454 bits (1168), Expect = e-128
 Identities = 255/485 (52%), Positives = 329/485 (67%), Gaps = 16/485 (3%)

Query: 5   APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64
           +P RL+ELA Q LL+D+ALAI+ +E LPRELFP LFM AF  R  +TLK MVQAWPFT L
Sbjct: 22  SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81

Query: 65  PLGSLMKSPHL--ESLKSVLEGVDVLLTQEVRPRQSKLQVLDLR-NVDENFCDIFSGATA 121
           PLG LMK  HL  E+ K+VL+G+DVLL QEVRPR+ KLQVLDLR N  ++F  ++SG  A
Sbjct: 82  PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141

Query: 122 S---FPEA-----LSQKQTADNCPGTGRQQPFM---VFIDLCLKNRTLDECLTHLLEWGK 170
           S   FPE      +++K+  D    T  +QPF+   V +DL LK    DE  ++L+E  K
Sbjct: 142 SLYSFPEPEAAQPMTKKRKVDGL-STEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVK 200

Query: 171 QRKGLLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMR 230
           ++K +L +CCK+L++F MP+  I  +L MV+LD I+++EV C W+L TL KF+PYLGQM 
Sbjct: 201 RKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSPYLGQMI 260

Query: 231 NLRKLVLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCL 290
           NLR+L+L +I AS+ I P+ + Q+IA+FTSQFL L   Q L + S+ FL G LDQLLR +
Sbjct: 261 NLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHV 320

Query: 291 QASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATL 350
              LE + +T+C LSE D+ HLS  PS+ QL  L L GV LT  SPEPL  LLE+  ATL
Sbjct: 321 MNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATL 380

Query: 351 QTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLEL 410
           Q L  ++CGI D QL A+LP LS CSQL+T SF GN IS++AL++LL+H +GLS L+  L
Sbjct: 381 QDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVL 440

Query: 411 YPAPLESY-DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEP 469
           YP PLESY D  G L   R A L A L + L +L +P ++     PCP CG R  YD EP
Sbjct: 441 YPVPLESYEDIHGTLHLERLAYLHARLRELLCELGRPSMVWLSANPCPHCGDRTFYDPEP 500

Query: 470 SHCLC 474
             C C
Sbjct: 501 ILCPC 505


>gi|5174641 preferentially expressed antigen in melanoma [Homo
           sapiens]
          Length = 509

 Score =  454 bits (1168), Expect = e-128
 Identities = 255/485 (52%), Positives = 329/485 (67%), Gaps = 16/485 (3%)

Query: 5   APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64
           +P RL+ELA Q LL+D+ALAI+ +E LPRELFP LFM AF  R  +TLK MVQAWPFT L
Sbjct: 22  SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81

Query: 65  PLGSLMKSPHL--ESLKSVLEGVDVLLTQEVRPRQSKLQVLDLR-NVDENFCDIFSGATA 121
           PLG LMK  HL  E+ K+VL+G+DVLL QEVRPR+ KLQVLDLR N  ++F  ++SG  A
Sbjct: 82  PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141

Query: 122 S---FPEA-----LSQKQTADNCPGTGRQQPFM---VFIDLCLKNRTLDECLTHLLEWGK 170
           S   FPE      +++K+  D    T  +QPF+   V +DL LK    DE  ++L+E  K
Sbjct: 142 SLYSFPEPEAAQPMTKKRKVDGL-STEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVK 200

Query: 171 QRKGLLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMR 230
           ++K +L +CCK+L++F MP+  I  +L MV+LD I+++EV C W+L TL KF+PYLGQM 
Sbjct: 201 RKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSPYLGQMI 260

Query: 231 NLRKLVLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCL 290
           NLR+L+L +I AS+ I P+ + Q+IA+FTSQFL L   Q L + S+ FL G LDQLLR +
Sbjct: 261 NLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHV 320

Query: 291 QASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATL 350
              LE + +T+C LSE D+ HLS  PS+ QL  L L GV LT  SPEPL  LLE+  ATL
Sbjct: 321 MNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATL 380

Query: 351 QTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLEL 410
           Q L  ++CGI D QL A+LP LS CSQL+T SF GN IS++AL++LL+H +GLS L+  L
Sbjct: 381 QDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVL 440

Query: 411 YPAPLESY-DTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEP 469
           YP PLESY D  G L   R A L A L + L +L +P ++     PCP CG R  YD EP
Sbjct: 441 YPVPLESYEDIHGTLHLERLAYLHARLRELLCELGRPSMVWLSANPCPHCGDRTFYDPEP 500

Query: 470 SHCLC 474
             C C
Sbjct: 501 ILCPC 505


>gi|12738831 PRAME family member 1 [Homo sapiens]
          Length = 474

 Score =  450 bits (1157), Expect = e-126
 Identities = 258/478 (53%), Positives = 327/478 (68%), Gaps = 11/478 (2%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSI+APPRLLELA Q LLRDQAL+IS MEELPR L+  LFMEAFSRR  +TL  MVQAWP
Sbjct: 1   MSIQAPPRLLELAGQSLLRDQALSISAMEELPRVLYLPLFMEAFSRRHFQTLTVMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           FT LPLGSLMK+ HLE+LK++LEG+ +LLTQ+ RPR+ KLQVLDLR+VDENF   + GA 
Sbjct: 61  FTCLPLGSLMKTLHLETLKALLEGLHMLLTQKDRPRRWKLQVLDLRDVDENFWARWPGAW 120

Query: 121 A--SFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A   FPE  S++QTA++CP  G  QP  VFID+CLK    DECL +L +W  QR+GL+H+
Sbjct: 121 ALSCFPETTSKRQTAEDCPRMGEHQPLKVFIDICLKEIPQDECLRYLFQWVYQRRGLVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CC +L  +  PI  + + L ++ L+ IQE+E+        + K   YL +M+NLRKLV  
Sbjct: 181 CCSKLVNYLTPIKYLRKSLKIIYLNSIQELEIRNMSWPRLIRKLRCYLKEMKNLRKLVF- 239

Query: 239 NIRASAC--IPPDNK--GQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASL 294
               S C     DN+  G+ +A+F+S FL+L++ Q L +  ++F  GHL+QL+RCLQ  L
Sbjct: 240 ----SRCHHYTSDNELQGRLVAKFSSVFLRLEHLQLLKIKLITFFSGHLEQLIRCLQNPL 295

Query: 295 EMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLD 354
           E + +T   L E D+K LS  PS+  LK L+L  V L   S EPL  LLE++ A+L+TL 
Sbjct: 296 ENLELTYGYLLEEDMKCLSQYPSLGYLKHLNLSYVLLFRISLEPLGALLEKIAASLKTLI 355

Query: 355 LEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAP 414
           LE C I  SQLSAILP LSRCSQL+TF F  N +S+ AL++LLRHT GLSKLSLE YPAP
Sbjct: 356 LEGCQIHYSQLSAILPALSRCSQLTTFYFGRNCMSIDALKDLLRHTSGLSKLSLETYPAP 415

Query: 415 LESYDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHC 472
            ES ++   + W  F  L AELM TLR++RQPK I     PCP CG   S +LE   C
Sbjct: 416 EESLNSLVRVNWEIFTPLRAELMCTLREVRQPKRIFIGPTPCPSCGSSPSEELELHLC 473


>gi|153791443 PRAME family member 18 [Homo sapiens]
          Length = 479

 Score =  448 bits (1153), Expect = e-126
 Identities = 248/479 (51%), Positives = 326/479 (68%), Gaps = 11/479 (2%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MS +AP RLLELA Q LLRDQALAIS ++ELPRELFP LF+EAF+ RRCE LK MVQAWP
Sbjct: 1   MSFQAPRRLLELAGQSLLRDQALAISVLDELPRELFPRLFVEAFTSRRCEVLKVMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F  LPLGSLMK+P LE L  V++G+D LL Q+VRPR+ KLQVL++R+VDENF  I+SGA 
Sbjct: 61  FPCLPLGSLMKTPDLEILHYVVDGIDCLLAQKVRPRRWKLQVLEMRDVDENFWTIWSGAR 120

Query: 121 --ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
             +  PEA+S++QT ++CP TG +QP  VF+D+CLK +++DE L+    W + R+  +H+
Sbjct: 121 PLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKSVDEDLSFFSGWVQHRRRSVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEV---CCPWELSTLVKFAPYLGQMRNLRKL 235
           CC ++  + M I +   +L  V  D IQ +E+   C P  ++ + +   YL QM+NLRKL
Sbjct: 181 CCTKVVNYSMNILNFRNILETVYPDSIQVLEIWNMCWPCMVAEVSR---YLSQMKNLRKL 237

Query: 236 VLFNIRASACIPP-DNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASL 294
            + +      +P  +++GQ +A F+S FL+L+Y Q L M  + F EG+LDQL+RCL++ L
Sbjct: 238 FISD--GCGYLPSFESQGQLVAEFSSVFLRLEYLQMLYMRRIRFFEGYLDQLIRCLKSPL 295

Query: 295 EMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLD 354
           E + +T   L E DLK L W PS+ QLK+L+L   TL     EPL  LLE+V ATLQTL 
Sbjct: 296 ETLALTYGSLDEEDLKCLPWYPSLSQLKQLNLSHGTLRFIRLEPLRALLEKVAATLQTLF 355

Query: 355 LEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAP 414
           L DCGI DS+L  ILP LSRCS L+TF F GN  SM  L++LLRHT  LS LSLE YPAP
Sbjct: 356 LVDCGIGDSKLRVILPALSRCSNLTTFCFHGNDTSMDGLKDLLRHTGRLSNLSLETYPAP 415

Query: 415 LESYDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCL 473
            ES D +G +       L AELM+ LR++R+P  I F  V CP CG+  +  LE + CL
Sbjct: 416 RESLDNRGRVISELLTPLQAELMRILREVREPNRIFFGPVSCPCCGMSPTEQLEFNFCL 474


>gi|66954681 PRAME family member 13 [Homo sapiens]
          Length = 474

 Score =  448 bits (1153), Expect = e-126
 Identities = 255/476 (53%), Positives = 325/476 (68%), Gaps = 7/476 (1%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSI+APPRLLELA Q LLRDQAL+IS MEELPR L+  LFMEAF RR  +TL  MVQAWP
Sbjct: 1   MSIQAPPRLLELAGQSLLRDQALSISAMEELPRVLYLPLFMEAFRRRHFQTLTVMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           FT LPLGSLMK+ HLE+LK++LEG+ +LLTQ+ RPR+ KLQVLDLR+VDENF   + GA 
Sbjct: 61  FTCLPLGSLMKTLHLETLKALLEGLHMLLTQKDRPRRWKLQVLDLRDVDENFWARWPGAW 120

Query: 121 A--SFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A   FPE +S++QTA++CP  G  QP  VFID+CLK    DECL +L +W  QR+GL+H+
Sbjct: 121 ALSCFPETMSKRQTAEDCPRMGEHQPLKVFIDICLKEIPQDECLRYLFQWVYQRRGLVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLF 238
           CC +L  +  PI  + + L ++ L+ IQ++E+        + K   YL +M+NLRKLV  
Sbjct: 181 CCSKLVNYLTPIKHLRKSLKIIYLNSIQQLEIRNMSWPRLIRKLRCYLKEMKNLRKLVFS 240

Query: 239 NIRASACIPPDNK--GQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEM 296
               S     DN+  G+ + +F+S FL+L++ Q L +  ++F  GHL+QL+RCLQ  LE 
Sbjct: 241 RCHHSMS---DNELEGRLVTKFSSVFLRLEHLQLLKIKLITFFSGHLEQLIRCLQNPLEN 297

Query: 297 VVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLE 356
           + +T   L E D+K LS  PS+  LK L+L  V L   S EPL  LLE++ A+L+TL LE
Sbjct: 298 LELTYGYLLEEDMKCLSQYPSLGYLKHLNLSYVLLFRISLEPLGALLEKIAASLETLILE 357

Query: 357 DCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLE 416
            C I  SQLSAILP LS CSQL+TF F  N +SM AL++LLRHT GLSKLSLE YPAP E
Sbjct: 358 GCQIHYSQLSAILPGLSHCSQLTTFYFGRNCMSMGALKDLLRHTSGLSKLSLETYPAPEE 417

Query: 417 SYDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHC 472
           S ++   + W  FA L AELM TLR++RQPK I     PCP CG   S +LE   C
Sbjct: 418 SLNSLVRVDWEIFALLRAELMCTLREVRQPKRIFIGPTPCPSCGSSPSEELELHLC 473


>gi|194018546 PRAME family member 10 [Homo sapiens]
          Length = 474

 Score =  446 bits (1146), Expect = e-125
 Identities = 248/463 (53%), Positives = 315/463 (68%), Gaps = 5/463 (1%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MS++AP RLLELA Q LLR+Q L I T++ELPRE+FP +FMEAFS RR E LK MVQAWP
Sbjct: 1   MSLQAPSRLLELAGQSLLRNQFLTIFTLDELPREVFPLMFMEAFSMRRFEALKLMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F  LPLGSLMK+ HLE+L++VL G+D L+ Q+VRPR+ KLQVLDLR+VDENF  I+SGA 
Sbjct: 61  FLSLPLGSLMKTLHLETLQAVLRGLDTLVAQKVRPRRWKLQVLDLRDVDENFWTIWSGAR 120

Query: 121 --ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
             +  PEA+S++QT ++CP  G  QP  VFIDLCLK  TLDECL++L  W   R+GL+H+
Sbjct: 121 VLSCSPEAMSKRQTVEDCPRMGEHQPLKVFIDLCLKESTLDECLSYLFGWIHYRRGLVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVL- 237
           CC ++Q + MP  S   +L  +  D IQE+EV     L+   KFAPYL QM NLR+L L 
Sbjct: 181 CCSKVQNYSMPTSSFRNLLERIYPDSIQELEVWKKCSLNKTGKFAPYLSQMSNLRELFLA 240

Query: 238 FNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMV 297
           F       +    +   I    S FL L Y Q L +  +S ++ HL+ LLR L+  L   
Sbjct: 241 FGYERELYVSV--QWPCIPDLDSPFLCLYYPQMLYIKKISNIKEHLEHLLRYLKNPLGAF 298

Query: 298 VMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLED 357
           + +D  L++ D++ LS  PS+ QLKEL L  + +     EPL  LLE+V ATL+TL L+D
Sbjct: 299 IFSDAYLTDRDMECLSQYPSLSQLKELRLIHILMWTTHLEPLGVLLEKVAATLKTLVLKD 358

Query: 358 CGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLES 417
           C I D QL  +LP LS CSQL+TF+F GN  SM AL++LLRHT GLSKL LELYPAPLES
Sbjct: 359 CRIQDPQLRVLLPALSHCSQLTTFNFHGNETSMNALKDLLRHTGGLSKLGLELYPAPLES 418

Query: 418 YDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCG 460
            D +G + W     + AELM+TLR++RQPK I F  VPCP CG
Sbjct: 419 LDYKGHVNWEILTPIRAELMRTLREVRQPKRIFFGPVPCPNCG 461


>gi|194306635 PRAME family member 19 [Homo sapiens]
          Length = 479

 Score =  445 bits (1144), Expect = e-125
 Identities = 247/479 (51%), Positives = 325/479 (67%), Gaps = 11/479 (2%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MS +AP RLLELA Q LLRDQALAIS ++ELPRELFP LF+EAF+ RRCE LK MVQAWP
Sbjct: 1   MSFQAPRRLLELAGQSLLRDQALAISVLDELPRELFPRLFVEAFTSRRCEVLKVMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F  LPLGSLMK+P LE L  V++G+D LL Q+VRPR+ KLQVL++R+VDENF  I+SGA 
Sbjct: 61  FPCLPLGSLMKTPDLEILHYVVDGIDCLLAQKVRPRRWKLQVLEMRDVDENFWTIWSGAR 120

Query: 121 --ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
             +  PEA+S++QT ++CP TG +QP  VF+D+CLK +++DE L+    W + R+  +H+
Sbjct: 121 PLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKSVDEDLSFFSGWVQHRRRSVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEV---CCPWELSTLVKFAPYLGQMRNLRKL 235
           CC ++  + M I +   +L  V  D IQ +E+   C P  ++ + +   YL QM+NLRKL
Sbjct: 181 CCTKVVNYSMNILNFRNILETVYPDSIQVLEIWNMCWPCMVAEVSR---YLSQMKNLRKL 237

Query: 236 VLFNIRASACIPP-DNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASL 294
            + +      +P  +++GQ +A F+S FL+L+Y Q L M  + F EG+LDQL+RCL++ L
Sbjct: 238 FISD--GCGYLPSFESQGQLVAEFSSVFLRLEYLQMLYMRRIRFFEGYLDQLIRCLKSPL 295

Query: 295 EMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLD 354
           E + +T   L E DLK L W PS+ QLK+L+L   TL     EPL  LLE+V ATLQTL 
Sbjct: 296 ETLALTYGSLDEEDLKCLPWYPSLSQLKQLNLSHGTLRFIRLEPLRALLEKVAATLQTLF 355

Query: 355 LEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAP 414
           L DCGI  S+L  ILP LSRCS L+TF F GN  SM  L++LLRHT  LS LSLE YPAP
Sbjct: 356 LVDCGIGYSKLRVILPALSRCSNLTTFCFHGNDTSMDGLKDLLRHTGRLSNLSLETYPAP 415

Query: 415 LESYDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCL 473
            ES D +G +       L AELM+ LR++R+P  I F  V CP CG+  +  LE + CL
Sbjct: 416 RESLDNRGRVISELLTPLQAELMRILREVREPNRIFFGPVSCPCCGMSPTEQLEFNFCL 474


>gi|154800493 PRAME family member 22 [Homo sapiens]
          Length = 481

 Score =  441 bits (1134), Expect = e-124
 Identities = 247/478 (51%), Positives = 320/478 (66%), Gaps = 9/478 (1%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MS++AP RLLELA Q LL DQALAIS ++ELPRELFP LF+EAF+ RRCE LK MVQAWP
Sbjct: 3   MSLQAPRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQAWP 62

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F  LPLGSLMK+P LE L  V++G+D LL Q+VRPR+ KLQVL+LR+VDENF  I+SGA 
Sbjct: 63  FPCLPLGSLMKTPDLEILHYVVDGIDCLLAQKVRPRRWKLQVLELRDVDENFWTIWSGAR 122

Query: 121 --ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
             +  PEA+S++QT ++CP TG +QP  VF+D+CLK + +DE L+    W + R+G +H+
Sbjct: 123 PLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRGSVHL 182

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEV---CCPWELSTLVKFAPYLGQMRNLRKL 235
           CC ++  + M I +   +L  V  D IQ +E+   C P     +V+F+ YL QMRNLRKL
Sbjct: 183 CCTKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWP---CMIVEFSRYLSQMRNLRKL 239

Query: 236 VLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLE 295
            + +      +  D++ Q +A F+S  L+L+Y Q L +  V F  GHLDQL+RCL++ LE
Sbjct: 240 FISD-GCRYLLSSDSQEQLVAEFSSVLLRLEYLQMLYVRRVCFFRGHLDQLIRCLRSPLE 298

Query: 296 MVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDL 355
            + +T   L + DLK L   PS+ QLK+L+L    L     EPL  LLE+V ATLQTL L
Sbjct: 299 TLALTYGFLEKVDLKCLPRYPSLSQLKQLNLSHGALRFIRLEPLRALLEKVAATLQTLFL 358

Query: 356 EDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPL 415
            DCGI DS+L  ILP LS CS L+TF F GN  SM  L++LLRHT  LS LSLE YPAP 
Sbjct: 359 VDCGIRDSKLRVILPALSCCSNLTTFCFHGNDTSMDGLKDLLRHTGRLSNLSLETYPAPR 418

Query: 416 ESYDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCL 473
           ES D +G +       L AELM+ LR++R+PK I F  V CP CG   +  LE + CL
Sbjct: 419 ESLDDRGRVISELLTPLQAELMRILREVREPKRIFFGPVSCPCCGTSPTEQLEFNFCL 476


>gi|194306638 PRAME family member 3 [Homo sapiens]
          Length = 481

 Score =  441 bits (1134), Expect = e-124
 Identities = 247/478 (51%), Positives = 319/478 (66%), Gaps = 9/478 (1%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MS++AP RLLELA Q LL DQALAIS ++ELPRELFP LF+EAF+ RRCE LK MVQAWP
Sbjct: 3   MSLQAPRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQAWP 62

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F  LPLGSLMK+P LE L  V++G+D LL Q+VRPR+ KLQVL+LR+VDENF  I+SGA 
Sbjct: 63  FPCLPLGSLMKTPDLEILHYVVDGIDCLLAQKVRPRRRKLQVLELRDVDENFWTIWSGAR 122

Query: 121 --ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
             +  PEA+S++QT ++CP TG +QP  VF+D+CLK + +DE L+    W + R+G +H+
Sbjct: 123 PLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRGSVHL 182

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEV---CCPWELSTLVKFAPYLGQMRNLRKL 235
           CC ++  + M I +   +L  V  D IQ +E+   C P     +V+F  YL QMRNLRKL
Sbjct: 183 CCTKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWP---CMIVEFIRYLSQMRNLRKL 239

Query: 236 VLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLE 295
            + +      +  D++ Q +A F+S  L+L+Y Q L +  V F  GHLDQL+RCL++ LE
Sbjct: 240 FISD-GCRYLLSSDSQEQLVAEFSSVLLRLEYLQMLYVRRVCFFRGHLDQLIRCLRSPLE 298

Query: 296 MVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDL 355
            + +T   L + DLK L   PS+ QLK+L+L    L     EPL  LLE+V ATLQTL L
Sbjct: 299 TLALTYGFLEKVDLKCLPRYPSLSQLKQLNLSHGALRFIRLEPLRALLEKVAATLQTLFL 358

Query: 356 EDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPL 415
            DCGI DS+L  ILP LS CS L+TF F GN  SM  L++LLRHT  LS LSLE YPAP 
Sbjct: 359 VDCGIRDSKLRVILPALSCCSNLTTFCFHGNDTSMDGLKDLLRHTGRLSNLSLETYPAPR 418

Query: 416 ESYDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCL 473
           ES D +G +       L AELM+ LR++R+PK I F  V CP CG   +  LE + CL
Sbjct: 419 ESLDDRGRVISELLTPLQAELMRILREVREPKRIFFGPVSCPCCGTSPTEQLEFNFCL 476


>gi|157426839 PRAME family member 17 [Homo sapiens]
          Length = 474

 Score =  440 bits (1132), Expect = e-123
 Identities = 244/463 (52%), Positives = 311/463 (67%), Gaps = 5/463 (1%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MS+++P RLLELA Q LLR+Q L I  ++ELPRE+FP +FMEA S R  E LK MVQAWP
Sbjct: 1   MSLQSPSRLLELAGQSLLRNQFLTIFILDELPREVFPLMFMEASSMRHFEALKLMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPLGSLMK+PHLE+L++VL+G+D LL Q++RPR+ KLQVLDLR+VD NF  I+SGA 
Sbjct: 61  FLRLPLGSLMKTPHLETLQAVLKGLDTLLAQKLRPRRWKLQVLDLRDVDGNFWTIWSGAR 120

Query: 121 A--SFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A    PEA+S++QT ++ P TG  QP  VFIDLC K  TLDECL++L  W   R+GL+H+
Sbjct: 121 ALSCSPEAMSKRQTVEDYPRTGEHQPLKVFIDLCQKESTLDECLSYLCRWIHYRRGLVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVL- 237
           CC ++Q + MP  S   +L  V  D IQE+E+     L+   KFAPYL QM NLRKL L 
Sbjct: 181 CCNKVQNYSMPTSSFRNLLKRVYPDSIQELEIKRKCSLNKTGKFAPYLSQMSNLRKLFLA 240

Query: 238 FNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMV 297
           F       +    + QF+      FL L Y Q L +  +S ++ HL+ LLRCL+  L   
Sbjct: 241 FGYDDELYV--SGQQQFVPDLDCPFLCLYYPQMLYIRKISNIKEHLEHLLRCLKNPLGTF 298

Query: 298 VMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLED 357
           +     L++ D++ LS  PS+ QLKEL L  + +   + EPL  LLE+V ATL+ L L+D
Sbjct: 299 IFCHAYLADQDMECLSQYPSLSQLKELHLIHILMWTTNLEPLGALLEKVAATLEILTLKD 358

Query: 358 CGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLES 417
           C I DSQL  +LP LSRCSQL+TF F GN  S  AL++LL HT GLSKL LELYPAPLE 
Sbjct: 359 CQIQDSQLRVLLPALSRCSQLTTFYFRGNETSTNALKDLLCHTGGLSKLGLELYPAPLEC 418

Query: 418 YDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCG 460
            D +G + W   A + AELM TLR++RQPK I F  +PCP CG
Sbjct: 419 LDNRGHVNWEILAPIRAELMCTLREVRQPKRIFFGPIPCPSCG 461


>gi|113865933 PRAME family member 16 [Homo sapiens]
          Length = 474

 Score =  438 bits (1127), Expect = e-123
 Identities = 243/463 (52%), Positives = 310/463 (66%), Gaps = 5/463 (1%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MS+++P RLLELA Q LLR+Q L I  ++ELPRE+FP +FMEA S R  E LK MVQAWP
Sbjct: 1   MSLQSPSRLLELAGQSLLRNQFLTIFILDELPREVFPLMFMEASSMRHFEALKLMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           F RLPLGSLMK+PHLE+L++VL+G+D LL Q++RPR+ KLQVLDLR+VD NF  I+SGA 
Sbjct: 61  FLRLPLGSLMKTPHLETLQAVLKGLDTLLAQKLRPRRWKLQVLDLRDVDGNFWTIWSGAR 120

Query: 121 A--SFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A    PEA+ ++QT ++ P TG  QP  VFIDLC K  TLDECL++L  W   R+GL+H+
Sbjct: 121 ALSCSPEAMRKRQTVEDYPRTGEHQPLKVFIDLCQKESTLDECLSYLCRWIHYRRGLVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVL- 237
           CC ++Q + MP  S   +L  V  D IQE+E+     L+   KFAPYL QM NLRKL L 
Sbjct: 181 CCNKVQNYSMPTSSFRNLLKRVYPDSIQELEIKRKCSLNKTGKFAPYLSQMSNLRKLFLA 240

Query: 238 FNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMV 297
           F       +    + QF+      FL L Y Q L +  +S ++ HL+ LLRCL+  L   
Sbjct: 241 FGYDDELYV--SGQQQFVPDLDCPFLCLYYPQMLYIRKISNIKEHLEHLLRCLKNPLGTF 298

Query: 298 VMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLED 357
           +     L++ D++ LS  PS+ QLKEL L  + +   + EPL  LLE+V ATL+ L L+D
Sbjct: 299 IFCHAYLADQDMECLSQYPSLSQLKELHLIHILMWTTNLEPLGALLEKVAATLEILTLKD 358

Query: 358 CGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLES 417
           C I DSQL  +LP LSRCSQL+TF F GN  S  AL++LL HT GLSKL LELYPAPLE 
Sbjct: 359 CQIQDSQLRVLLPALSRCSQLTTFYFRGNETSTNALKDLLCHTGGLSKLGLELYPAPLEC 418

Query: 418 YDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCG 460
            D +G + W   A + AELM TLR++RQPK I F  +PCP CG
Sbjct: 419 LDNRGHVNWEILAPIRAELMCTLREVRQPKRIFFGPIPCPSCG 461


>gi|12738834 PRAME family member 2 [Homo sapiens]
          Length = 474

 Score =  437 bits (1123), Expect = e-122
 Identities = 257/481 (53%), Positives = 322/481 (66%), Gaps = 17/481 (3%)

Query: 1   MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWP 60
           MSI+APPRLLELA Q LLRDQAL+IS MEELPR L+  LF EAFSRR  +TL  MVQAWP
Sbjct: 1   MSIQAPPRLLELAGQSLLRDQALSISAMEELPRVLYLPLFREAFSRRHFQTLTVMVQAWP 60

Query: 61  FTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT 120
           FT LPL SLMK+ HLE LK++LEG+ +LLTQ+ RPR+ KLQVLDLR+VDENF   + GA 
Sbjct: 61  FTCLPLVSLMKTLHLEPLKALLEGLHMLLTQKDRPRRWKLQVLDLRDVDENFWARWPGAW 120

Query: 121 A--SFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHV 178
           A   FPEA+S++QTA++CP TG  QP  VFID+CLK    DECL +L +W  QR+GL+H+
Sbjct: 121 ALSCFPEAMSKRQTAEDCPRTGEHQPLKVFIDICLKEIPQDECLRYLFQWVYQRRGLVHL 180

Query: 179 CCKELQVFGMPIHSIIEVLNMVELDCIQEVEV---CCPWELSTLVKFAPYLGQMRNLRKL 235
           CC +L  +  PI  + + L ++ ++ I E+E+   C P     + K   YL +M+ L KL
Sbjct: 181 CCSKLVNYLTPIKYLRKSLKIIYINSIGELEIHNTCWP---HLIRKLYCYLKEMKTLCKL 237

Query: 236 VLFNIRASAC--IPPDNK--GQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQ 291
           V      S C     DN+  G  + RFTS FL+L++ Q L +  ++F  GHL+QL+RCLQ
Sbjct: 238 VF-----SRCHHYTSDNELEGWLVTRFTSVFLRLEHLQLLKIKLITFFSGHLEQLIRCLQ 292

Query: 292 ASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQ 351
             LE + +T   L E DLK LS  PS+  LK L+L  V L   S EPL  LLE++ A+L+
Sbjct: 293 NPLENLELTCGNLLEEDLKCLSQFPSLGYLKHLNLSYVLLFRISLEPLGALLEKIAASLE 352

Query: 352 TLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELY 411
           TL LE C I  SQLSAILP LS CSQL+TF F  N +S+ AL++LLRHT GLSKLSLE Y
Sbjct: 353 TLVLEGCQIHYSQLSAILPGLSCCSQLTTFYFGSNCMSIDALKDLLRHTSGLSKLSLETY 412

Query: 412 PAPLESYDTQGALCWGRFAELGAELMKTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSH 471
           PAP ES ++   + W  F  L AELM TLR+ RQPK I     PCP CG   S +LE   
Sbjct: 413 PAPEESLNSLVRVNWEIFTPLRAELMCTLREFRQPKRIFIGPTPCPSCGSSPSEELELHL 472

Query: 472 C 472
           C
Sbjct: 473 C 473


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.138    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,329,510
Number of Sequences: 37866
Number of extensions: 728501
Number of successful extensions: 2278
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 2132
Number of HSP's gapped (non-prelim): 75
length of query: 474
length of database: 18,247,518
effective HSP length: 106
effective length of query: 368
effective length of database: 14,233,722
effective search space: 5238009696
effective search space used: 5238009696
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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