Search of human proteins with 238908508

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
         (860 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|238908508 leucine-rich repeat and death domain-containing pro...  1679   0.0  
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]          219   1e-56
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom...   210   4e-54
gi|95113664 leucine rich repeat containing 1 [Homo sapiens]           192   9e-49
gi|21361633 leucine rich repeat containing 40 [Homo sapiens]          176   6e-44
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]        170   5e-42
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]         170   5e-42
gi|16904383 leucine rich repeat containing 7 [Homo sapiens]           160   4e-39
gi|45827729 scribble isoform b [Homo sapiens]                         156   9e-38
gi|45827731 scribble isoform a [Homo sapiens]                         156   9e-38
gi|110825984 malignant fibrous histiocytoma amplified sequence 1...   155   2e-37
gi|4503743 flightless I homolog [Homo sapiens]                        144   5e-34
gi|37221175 PH domain and leucine rich repeat protein phosphatas...   133   8e-31
gi|65301141 PH domain and leucine rich repeat protein phosphatas...   131   3e-30
gi|19923729 leucine rich repeat containing 8 family, member C [H...   115   1e-25
gi|197333692 leucine rich repeat containing 8 family, member B [...   115   2e-25
gi|21245134 leucine rich repeat containing 8 family, member B [H...   115   2e-25
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   112   2e-24
gi|193788651 leucine rich repeat containing 69 [Homo sapiens]         112   2e-24
gi|14249428 leucine-rich repeats and calponin homology (CH) doma...   108   2e-23
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   107   5e-23
gi|4507531 toll-like receptor 3 [Homo sapiens]                        107   6e-23
gi|21389431 leucine rich repeat containing 39 [Homo sapiens]          106   1e-22
gi|62241040 leucine rich repeat containing 8 family, member A [H...   106   1e-22
gi|187829877 leucine rich repeat containing 8 family, member A [...   106   1e-22
gi|187829871 leucine rich repeat containing 8 family, member A [...   106   1e-22
gi|197333706 leucine rich repeat containing 8 family, member D [...   105   2e-22
gi|34222199 leucine rich repeat containing 8 family, member D [H...   105   2e-22
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   105   2e-22
gi|190014581 leucine rich repeat containing 2 [Homo sapiens]          103   5e-22

>gi|238908508 leucine-rich repeat and death domain-containing
           protein [Homo sapiens]
          Length = 860

 Score = 1679 bits (4348), Expect = 0.0
 Identities = 860/860 (100%), Positives = 860/860 (100%)

Query: 1   MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETHP 60
           MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETHP
Sbjct: 1   MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETHP 60

Query: 61  RQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHE 120
           RQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHE
Sbjct: 61  RQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHE 120

Query: 121 TVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQ 180
           TVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQ
Sbjct: 121 TVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQ 180

Query: 181 GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF 240
           GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF
Sbjct: 181 GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF 240

Query: 241 FYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300
           FYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC
Sbjct: 241 FYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300

Query: 301 FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360
           FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK
Sbjct: 301 FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360

Query: 361 LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL 420
           LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL
Sbjct: 361 LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL 420

Query: 421 RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP 480
           RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP
Sbjct: 421 RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP 480

Query: 481 LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDL 540
           LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDL
Sbjct: 481 LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDL 540

Query: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600
           GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN
Sbjct: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600

Query: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660
           LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN
Sbjct: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660

Query: 661 NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF 720
           NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF
Sbjct: 661 NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF 720

Query: 721 SLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFE 780
           SLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFE
Sbjct: 721 SLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFE 780

Query: 781 FLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIG 840
           FLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIG
Sbjct: 781 FLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIG 840

Query: 841 AYEIMDKITALNLFTRAIKF 860
           AYEIMDKITALNLFTRAIKF
Sbjct: 841 AYEIMDKITALNLFTRAIKF 860


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score =  219 bits (557), Expect = 1e-56
 Identities = 143/483 (29%), Positives = 254/483 (52%), Gaps = 28/483 (5%)

Query: 216 LNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDT 275
           L++S   I  +P  I +L  + +L+ Y+N +++ P+++ CL NL  L+L +N L  +PD+
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164

Query: 276 LPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDH 335
           L +LK LR+L+L +N+L   P  +  L  L +L L  N I+++ K+I+ L  L  L +  
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224

Query: 336 NKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCA 395
           NK+  L  EI +L  +  L +A N+LE +  +I N  ++  L L  N L ++P+ I   +
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284

Query: 396 MLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITD 455
            L  L L  N+L+ +P+ + K + L +L++  NN+  + + +                  
Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL------------------ 326

Query: 456 VPIEIKNCQKIIKIELSYNKIMYFPL-GLCALDSLYYLSVNGNYISEIPVDI-SFSKQLL 513
               + +  K+  + L+ N    +P+ G     ++Y L++  N I++IP  I S +K L 
Sbjct: 327 ----LSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLS 382

Query: 514 HLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPR 573
            L + +N+L      F +  ++  L+L  NQ+ KIP  +S ++SL VLIL  N  +  P 
Sbjct: 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPH 442

Query: 574 ELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633
            L  L  L+ LDL EN+L+ + ++I  LK +QKL  ++NQ    P  +  L +L  L + 
Sbjct: 443 GLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLG 502

Query: 634 QIKGRKLTRLPGELSNMTQLKELDISNNA-IREIPRNIGELRNLVSLHAYNNQISYLPPS 692
           +     LT LP E+  +  L+EL +++N  +  +P  +     L  +   N  +S+LPP 
Sbjct: 503 E---NLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQ 559

Query: 693 LLS 695
           +++
Sbjct: 560 IVA 562



 Score =  198 bits (504), Expect = 2e-50
 Identities = 149/479 (31%), Positives = 231/479 (48%), Gaps = 24/479 (5%)

Query: 193 LSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSD 252
           L L +  +  LPS I+ L  L  L +  N +  +P E+  L N+  L    N + + P  
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164

Query: 253 LECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTG 312
           L+ L  L +L L  NKLR IP  +  L +L  L L +N++TT  K +  L KL  L +  
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224

Query: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFR 372
           N I  LP EI EL NL TL + HN+L  L  EI    +I  L L  N+L  +   I N  
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284

Query: 373 ELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK 432
            L  L L  N L  IP  ++ C+ LE L+L +N ++ LP+ +  L++L KL    N++  
Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL--LSSLVKL----NSLTL 338

Query: 433 ITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA-LDSLYY 491
             +C          +FS                I  + + +N+I   P G+ +    L  
Sbjct: 339 ARNCFQLYPVGGPSQFS---------------TIYSLNMEHNRINKIPFGIFSRAKVLSK 383

Query: 492 LSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPAS 551
           L++  N ++ +P+D      ++ L L+ N+L    E    L++L+ L L  N +KK+P  
Sbjct: 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHG 443

Query: 552 ISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSS 611
           + N+  L  L L  NK E+ P E+  L++LQ L L+ NQL  +   I +L  +  L    
Sbjct: 444 LGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGE 503

Query: 612 NQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNI 670
           N   H P E+  L++LE+L ++      L  LP EL+  ++L  + I N  +  +P  I
Sbjct: 504 NLLTHLPEEIGTLENLEELYLND--NPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560



 Score =  187 bits (475), Expect = 4e-47
 Identities = 132/429 (30%), Positives = 214/429 (49%), Gaps = 6/429 (1%)

Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367
           LDL+   I  LP  I+EL  L  L +  NKL  L  E+  L+ +  L L++N L  +   
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164

Query: 368 IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNR 427
           ++N ++LR+L L  N L+ IP  +     L  L L  N++T + K I  L+ L  L +  
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224

Query: 428 NNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALD 487
           N + ++   I  L N+ +L+ + N +  +P EI NC +I  ++L +N+++  P  +  L 
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284

Query: 488 SLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCS-LINLKYLDLGKNQIK 546
           SL  L +  N +S IP  ++    L  L L  N +    E   S L+ L  L L +N  +
Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344

Query: 547 KIPASISNMIS-LHVLILCCNKFETFPRELCTLEN-LQVLDLSENQLQKISSDICNLKGI 604
             P    +  S ++ L +  N+    P  + +    L  L++ +NQL  +  D      +
Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSM 404

Query: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR 664
            +LN ++NQ    P ++  L SLE L +S      L +LP  L N+ +L+ELD+  N + 
Sbjct: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSN---NLLKKLPHGLGNLRKLRELDLEENKLE 461

Query: 665 EIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKE 724
            +P  I  L++L  L   NNQ++ LP  +  L +L  L L  N LT LP  I  + +L+E
Sbjct: 462 SLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEE 521

Query: 725 INFDDNPLL 733
           +  +DNP L
Sbjct: 522 LYLNDNPNL 530



 Score =  179 bits (453), Expect = 1e-44
 Identities = 118/412 (28%), Positives = 198/412 (48%), Gaps = 29/412 (7%)

Query: 354 LQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKY 413
           L L+   + ++   I+   +L  L L  N L+++P ++ C   L  L+LS+N LT LP  
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164

Query: 414 IHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSY 473
           +  L  LR L +  N + +I   +  L+++ +L    N IT V  +IKN  K+  + +  
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224

Query: 474 NKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLI 533
           NKI   P  +  L +L  L V  N +  +P +I    Q+ +L+L  N+LL   +   +L 
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284

Query: 534 NLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCT---------------- 577
           +L  L L  N++  IP S++   +L  L L  N   T P  L +                
Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344

Query: 578 ---------LENLQVLDLSENQLQKISSDICN-LKGIQKLNFSSNQFIHFPIELCQLQSL 627
                       +  L++  N++ KI   I +  K + KLN   NQ    P++     S+
Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSM 404

Query: 628 EQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQIS 687
            +LN++     +LT++P ++S +  L+ L +SNN ++++P  +G LR L  L    N++ 
Sbjct: 405 VELNLAT---NQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLE 461

Query: 688 YLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
            LP  +  L DLQ+L L+ N LT LP  I ++ +L  +   +N L   P EI
Sbjct: 462 SLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEI 513



 Score =  171 bits (434), Expect = 2e-42
 Identities = 138/552 (25%), Positives = 250/552 (45%), Gaps = 50/552 (9%)

Query: 61  RQNTLESTSSSGRKSKRNEEQKKNLQFSE-----TSTRTGTSQSLSSLTGRTAEYQALVN 115
           R+   +++   G++SK  E + K     +     ++ + G + S+ +   R         
Sbjct: 24  REKEAKASGGFGKESKEKEPKTKGKDAKDGKKDSSAAQPGVAFSVDNTIKRPNPAPGTRK 83

Query: 116 FLSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQ 175
             S+  V +   +  EEN  +L         +L  + +   P  I ++  +  LYL  N+
Sbjct: 84  KSSNAEVIKELNKCREENSMRL---------DLSKRSIHILPSSIKELTQLTELYLYSNK 134

Query: 176 IKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGN 235
           +++   A+ G L+ L  L+L EN L+SLP  +  L  LR+L++ HN +  IP  + +L +
Sbjct: 135 LQSLP-AEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193

Query: 236 IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTF 295
           +  L+   N I     D++ L  L +LS+ +NK++ +P  +  L  L  L++ +NQL   
Sbjct: 194 LTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHL 253

Query: 296 PKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQ 355
           PK +    ++ +LDL  N +  LP  I  L +L  L + +N+L+ +   + +   ++EL 
Sbjct: 254 PKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELN 313

Query: 356 LADNKLEVISHKI-------------------------ENFRELRILILDKNLLKNIPEK 390
           L +N +  +   +                           F  +  L ++ N +  IP  
Sbjct: 314 LENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFG 373

Query: 391 I-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFS 449
           I S   +L  L++ DN+LT LP       ++ +L++  N + KI + +S L ++  L  S
Sbjct: 374 IFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433

Query: 450 GNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFS 509
            N++  +P  + N +K+ +++L  NK+   P  +  L  L  L +  N ++ +P  I   
Sbjct: 434 NNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHL 493

Query: 510 KQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFE 569
             L HL L EN L    E   +L NL+ L L  N          N+ SL   +  C+K  
Sbjct: 494 TNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN---------PNLHSLPFELALCSKLS 544

Query: 570 TFPRELCTLENL 581
               E C L +L
Sbjct: 545 IMSIENCPLSHL 556



 Score =  120 bits (301), Expect = 5e-27
 Identities = 101/363 (27%), Positives = 164/363 (45%), Gaps = 23/363 (6%)

Query: 481 LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDL 540
           L  C  ++   L ++   I  +P  I    QL  L L  NKL         L+NL  L L
Sbjct: 94  LNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLAL 153

Query: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600
            +N +  +P S+ N+  L +L L  NK    P  +  L++L  L L  N++  +  DI N
Sbjct: 154 SENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKN 213

Query: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660
           L  +  L+   N+    P E+ +L +L  L+++     +L  LP E+ N TQ+  LD+ +
Sbjct: 214 LSKLSMLSIRENKIKQLPAEIGELCNLITLDVAH---NQLEHLPKEIGNCTQITNLDLQH 270

Query: 661 NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALP-SAIYNI 719
           N + ++P  IG L +L  L    N++S +P SL   + L++LNL  NN++ LP S + ++
Sbjct: 271 NELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSL 330

Query: 720 FSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNF 779
             L  +    N     PV    G   ++    L     R  KI   IF            
Sbjct: 331 VKLNSLTLARNCFQLYPV---GGPSQFSTIYSLNMEHNRINKIPFGIFSRAK-------- 379

Query: 780 EFLCQKLNLANSE-TDMPT-----KSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLI 833
             +  KLN+ +++ T +P       S V L+   +Q   I +  S  +SL    L + L+
Sbjct: 380 --VLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 437

Query: 834 RAL 836
           + L
Sbjct: 438 KKL 440



 Score =  117 bits (293), Expect = 5e-26
 Identities = 77/263 (29%), Positives = 125/263 (47%), Gaps = 3/263 (1%)

Query: 518 SENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCT 577
           S N  +I   + C   N   LDL K  I  +P+SI  +  L  L L  NK ++ P E+  
Sbjct: 85  SSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGC 144

Query: 578 LENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKG 637
           L NL  L LSEN L  +   + NLK ++ L+   N+    P  + +L SL  L    ++ 
Sbjct: 145 LVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTL---YLRF 201

Query: 638 RKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLN 697
            ++T +  ++ N+++L  L I  N I+++P  IGEL NL++L   +NQ+ +LP  + +  
Sbjct: 202 NRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT 261

Query: 698 DLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADE 757
            +  L+L  N L  LP  I N+ SL  +    N L   P  + K   L  +         
Sbjct: 262 QITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIST 321

Query: 758 RDEKILEKIFKIVANNITETNFE 780
             E +L  + K+ +  +    F+
Sbjct: 322 LPESLLSSLVKLNSLTLARNCFQ 344


>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
           sapiens]
          Length = 560

 Score =  210 bits (535), Expect = 4e-54
 Identities = 144/474 (30%), Positives = 237/474 (50%), Gaps = 11/474 (2%)

Query: 292 LTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKI 351
           LT  P  +    +L  + L  N I  +P+EI+ LKN+  L +D N L  L   +  L  +
Sbjct: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96

Query: 352 KELQLADNKLEVISHKIENF----RELRILILDKNLLKNIPEKI-SCCAMLECLSLSDNK 406
           + L L+ N +   S  + +F    RELR+   D   LK IP  I      LE L L+ N 
Sbjct: 97  ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTD---LKEIPVVIFKNLHHLELLGLTGNH 153

Query: 407 LTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466
           L  LPK I     LR++++ RN        +  L  +  ++   N I  +P EI +   +
Sbjct: 154 LKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGL 213

Query: 467 IKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFS 526
            K  ++ N +   P  LC    L  L ++ N +  IP   +  +++  + LS N+L    
Sbjct: 214 QKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273

Query: 527 EHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDL 586
              C   +L  L LG   + ++  S   +++L  L L  N     P ++C L+NL+VL L
Sbjct: 274 RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGL 333

Query: 587 SENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE 646
            +N++ ++ S++ +L  ++ L  + N+F+ FP E+  L SLE+L I Q +G KLT +P  
Sbjct: 334 DDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEH 393

Query: 647 LSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSG 706
           +  +  LKEL I NN +  +P ++G + NL  L   +N +  LP ++     L++L L  
Sbjct: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453

Query: 707 NNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC-KGKQLYTIARYLQRADERD 759
           N LT LP  + ++ +LK +   DNP+  PP E+C +G +   I +YL+    R+
Sbjct: 454 NLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNE--AIWKYLKENRNRN 505



 Score =  177 bits (448), Expect = 5e-44
 Identities = 130/458 (28%), Positives = 219/458 (47%), Gaps = 35/458 (7%)

Query: 129 VSEENQKQLGLGADNFT------VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGA 182
           +   NQ    +  + FT      V+LE   ++E P++I ++K ++ LYLDKN +++   A
Sbjct: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89

Query: 183 DSGDLLGLEILSLQENGLSSLP----------SEIQL---------------LHNLRILN 217
             G L  LE L L  N + S             E++L               LH+L +L 
Sbjct: 90  -LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLG 148

Query: 218 VSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLP 277
           ++ NH+  +PKEI     +R+++   N  E FP +L  L  LEI+ L +NK+  IP+ + 
Sbjct: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIG 208

Query: 278 SLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNK 337
            L  L+   +  N L   P +LC   +L  LDL+ NL+ S+PK   EL+ +  + +  N+
Sbjct: 209 HLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNR 268

Query: 338 LTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAML 397
           L  +   I +   +  L L +  L  +         LR L L +N L + P +I     L
Sbjct: 269 LEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNL 328

Query: 398 ECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSL---EFSGNIIT 454
           E L L DNK+ +LP  +  L+ L+ L +  N  +   + +  L ++  L   +  G  +T
Sbjct: 329 EVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLT 388

Query: 455 DVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514
            VP  I+  Q + ++ +  N + Y P+ L ++ +L  L    N + ++P  I  ++ L  
Sbjct: 389 YVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKE 448

Query: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASI 552
           L L +N L    E+  SL+NLK L L  N +++ P  +
Sbjct: 449 LRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 66/258 (25%), Positives = 110/258 (42%), Gaps = 26/258 (10%)

Query: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574
           ++ S   L        +   L+ + L  NQI++IP  I  + ++ VL L  N   +    
Sbjct: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89

Query: 575 LCTLENLQVLDLSENQLQKISSDICN-LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633
           L  L +L+ LDLS N +   S  + + L  +++L          P+ +   ++L  L + 
Sbjct: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVI--FKNLHHLELL 147

Query: 634 QIKGRKLTRLPGELSNMTQLKE-----------------------LDISNNAIREIPRNI 670
            + G  L  LP E+ N T+L+E                       +D+  N I  IP  I
Sbjct: 148 GLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEI 207

Query: 671 GELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDN 730
           G L  L   +  +N +  LP SL   + L  L+LS N L ++P +   +  + EI    N
Sbjct: 208 GHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGN 267

Query: 731 PLLRPPVEICKGKQLYTI 748
            L + P  IC+   L+ +
Sbjct: 268 RLEKVPRLICRWTSLHLL 285



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 52/181 (28%), Positives = 85/181 (46%), Gaps = 27/181 (14%)

Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
           ++L    L   P  I  +K ++ L LD N+I     ++ G L  L+IL L  N   S P 
Sbjct: 308 LDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLP-SELGSLSKLKILGLTGNEFLSFPE 366

Query: 206 EIQLLHNLRILNVSHNH---ISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEIL 262
           E+  L +L  L +  +    ++++P+ I +L ++++L+  NN++E  P  L  + NLE+L
Sbjct: 367 EVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVL 426

Query: 263 S-----------------------LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL 299
                                   L  N L H+P+ L SL  L+VL L  N +   PK +
Sbjct: 427 DCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486

Query: 300 C 300
           C
Sbjct: 487 C 487



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 35/120 (29%), Positives = 63/120 (52%), Gaps = 2/120 (1%)

Query: 157 PKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRIL 216
           P+ I K++ +K LY++ N ++ +     G +  LE+L  + N L  LP  I     L+ L
Sbjct: 391 PEHIRKLQSLKELYIENNHLE-YLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKEL 449

Query: 217 NVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILS-LGKNKLRHIPDT 275
            +  N ++H+P+ +  L N++ L   +N +E  P ++   GN  I   L +N+ R+I  T
Sbjct: 450 RLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNIMAT 509


>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
          Length = 524

 Score =  192 bits (489), Expect = 9e-49
 Identities = 123/369 (33%), Positives = 206/369 (55%), Gaps = 5/369 (1%)

Query: 318 LPKEI-RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRI 376
           +P+EI R  ++LE LL+D N+L  L  + FQL+K+++L L+DN+++ +  +I NF +L  
Sbjct: 27  VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86

Query: 377 LILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDC 436
           L + +N +  IPE IS C  L+    S N LT LP+   +L NL  L VN  ++  + + 
Sbjct: 87  LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146

Query: 437 ISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNG 496
           I +L N+ SLE   N++T +P  +   +++ +++L  N+I   P  + AL  L  L ++G
Sbjct: 147 IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDG 206

Query: 497 NYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMI 556
           N +SE+P +I   K LL L++SEN+L    E    L +L  L + +N ++ IP  I  + 
Sbjct: 207 NQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLK 266

Query: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616
            L +L +  N+    P  +   E+L  L L+ENQL  +   I  LK +  LN   N+ + 
Sbjct: 267 KLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVS 326

Query: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676
            P E+    S   L +  ++  +LTR+P E+S  T+L  LD++ N +  +P ++  L+ L
Sbjct: 327 LPKEIGGCCS---LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-L 382

Query: 677 VSLHAYNNQ 685
            +L   +NQ
Sbjct: 383 KALWLSDNQ 391



 Score =  170 bits (430), Expect = 6e-42
 Identities = 132/490 (26%), Positives = 228/490 (46%), Gaps = 12/490 (2%)

Query: 190 LEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENF 249
           LE L L  N L  LP +   L  LR L +S N I  +P EI+    + +L    N I   
Sbjct: 38  LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEI 97

Query: 250 PSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLD 309
           P  +     L++     N L  +P++ P L+ L  L++    L + P+ +  L  L SL+
Sbjct: 98  PESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLE 157

Query: 310 LTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIE 369
           L  NL++ LP  + +L+ LE L + +N++  L   I  LL +K+L L  N+L  +  +I 
Sbjct: 158 LRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG 217

Query: 370 NFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNN 429
           N + L  L + +N L+ +PE+IS    L  L +S N L  +P  I KL  L  L V++N 
Sbjct: 218 NLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNR 277

Query: 430 MVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSL 489
           + ++ + +    ++  L  + N +  +P  I   +K+  +    NK++  P  +    SL
Sbjct: 278 LTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSL 337

Query: 490 YYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKK-I 548
               V  N ++ IP ++S + +L  L+++ N+LL       +L  LK L L  NQ +  +
Sbjct: 338 TVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQSQPLL 396

Query: 549 PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLN 608
                   +    IL C      P E    ENL      EN +  +S +  N + + +++
Sbjct: 397 TFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVS 456

Query: 609 FSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQ-LKELDISNNAIREIP 667
                     I   + +  E+ N ++   R+ T  PGEL +M + ++ L    NA + + 
Sbjct: 457 ---------AIRFVEDEKDEEDNETRTLLRRATPHPGELKHMKKTVENLRNDMNAAKGLD 507

Query: 668 RNIGELRNLV 677
            N  E+ + +
Sbjct: 508 SNKNEVNHAI 517



 Score =  158 bits (400), Expect = 2e-38
 Identities = 109/354 (30%), Positives = 178/354 (50%), Gaps = 4/354 (1%)

Query: 387 IPEKISCCAM-LECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICS 445
           +PE+I   A  LE L L  N+L ELP+   +L  LRKL ++ N + ++   I++   +  
Sbjct: 27  VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86

Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
           L+ S N I ++P  I  C+ +   + S N +   P     L +L  LSVN   +  +P +
Sbjct: 87  LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146

Query: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565
           I     L  LEL EN L    +    L  L+ LDLG N+I  +P SI  ++ L  L L  
Sbjct: 147 IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDG 206

Query: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625
           N+    P+E+  L+NL  LD+SEN+L+++  +I  L  +  L  S N     P  + +L+
Sbjct: 207 NQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLK 266

Query: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685
            L  L + Q    +LT+LP  +     L EL ++ N +  +P++IG+L+ L +L+A  N+
Sbjct: 267 KLSILKVDQ---NRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK 323

Query: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
           +  LP  +     L    +  N LT +P+ +     L  ++   N LL  P+ +
Sbjct: 324 LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377



 Score =  119 bits (299), Expect = 9e-27
 Identities = 95/300 (31%), Positives = 138/300 (46%), Gaps = 26/300 (8%)

Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
           L    N + ++P +     K+ K+ LS N+I   P  +     L  L V+ N I EIP  
Sbjct: 41  LLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPES 100

Query: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565
           ISF K L   + S N L    E F  L NL  L +    ++ +P +I N+ +L  L L  
Sbjct: 101 ISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRE 160

Query: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625
           N     P  L  L  L+ LDL  N++  +   I  L  ++ L    NQ    P E+  L+
Sbjct: 161 NLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLK 220

Query: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685
           +L  L++S+    +L RLP E+S +T L +L IS N +  IP  IG+L+ L         
Sbjct: 221 NLLCLDVSE---NRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKL--------- 268

Query: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745
                 S+L ++         N LT LP A+    SL E+   +N LL  P  I K K+L
Sbjct: 269 ------SILKVDQ--------NRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKL 314



 Score =  110 bits (274), Expect = 7e-24
 Identities = 76/245 (31%), Positives = 123/245 (50%), Gaps = 4/245 (1%)

Query: 502 IPVDI-SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHV 560
           +P +I  +++ L  L L  N+L    E F  L+ L+ L L  N+I+++P  I+N + L  
Sbjct: 27  VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86

Query: 561 LILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIE 620
           L +  N+    P  +   + LQV D S N L ++      L+ +  L+ +       P  
Sbjct: 87  LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146

Query: 621 LCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLH 680
           +  L +L  L   +++   LT LP  L+ + +L+ELD+ NN I  +P +IG L +L  L 
Sbjct: 147 IGNLYNLASL---ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLW 203

Query: 681 AYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC 740
              NQ+S LP  + +L +L  L++S N L  LP  I  + SL ++    N L   P  I 
Sbjct: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIG 263

Query: 741 KGKQL 745
           K K+L
Sbjct: 264 KLKKL 268



 Score =  108 bits (269), Expect = 3e-23
 Identities = 67/224 (29%), Positives = 112/224 (50%), Gaps = 6/224 (2%)

Query: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616
           SL  L+L  N+    P +   L  L+ L LS+N++Q++  +I N   + +L+ S N+   
Sbjct: 37  SLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPE 96

Query: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676
            P  +   ++L+   ++   G  LTRLP     +  L  L +++ +++ +P NIG L NL
Sbjct: 97  IPESISFCKALQ---VADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNL 153

Query: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736
            SL    N ++YLP SL  L  L++L+L  N +  LP +I  +  LK++  D N L   P
Sbjct: 154 ASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELP 213

Query: 737 VEICKGKQLYTI---ARYLQRADERDEKILEKIFKIVANNITET 777
            EI   K L  +      L+R  E    +      +++ N+ ET
Sbjct: 214 QEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLET 257



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 72/263 (27%), Positives = 113/263 (42%), Gaps = 51/263 (19%)

Query: 121 TVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQ 180
           +V ++S Q   EN   +G   +  ++ L    L   P  + +++ ++ L L  N+I    
Sbjct: 134 SVNDISLQSLPEN---IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190

Query: 181 GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF 240
            +  G LL L+ L L  N LS LP EI  L NL  L+VS N +  +P+EIS L ++  L 
Sbjct: 191 ES-IGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLV 249

Query: 241 FYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300
              N +E  P  +  L  L IL + +N+L  +P+ +   ++L  L L  NQL T PK++ 
Sbjct: 250 ISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIG 309

Query: 301 FLPKLISL----------------------------------------------DLTGNL 314
            L KL +L                                              D+ GN 
Sbjct: 310 KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNR 369

Query: 315 ISSLPKEIRELKNLETLLMDHNK 337
           +  LP  +  LK L+ L +  N+
Sbjct: 370 LLHLPLSLTALK-LKALWLSDNQ 391


>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
          Length = 602

 Score =  176 bits (447), Expect = 6e-44
 Identities = 143/506 (28%), Positives = 245/506 (48%), Gaps = 52/506 (10%)

Query: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI 246
           L  L +L + +N L+SLPS I+ L NL+ LNVSHN +  +P+EI+ L N++ L+  +N +
Sbjct: 104 LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNEL 163

Query: 247 ENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLI 306
                  E L NLE L L  N L  +P +  SL +L  LNL  N+L + P  +  + +L 
Sbjct: 164 TCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLK 223

Query: 307 SLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI-S 365
            LD   NL+ ++P E+  +++LE L +  NKL FL  E      +KEL + +N++E++ +
Sbjct: 224 HLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIEMLEA 282

Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425
             +++   + +L L  N LK++P++I     LE L LS+N ++ LP  +  L +L+ L +
Sbjct: 283 EHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLAL 341

Query: 426 NRNNMVKITDCISHLNNICSLEFSGNIITD---------------VPIEIK-NCQKIIKI 469
             N +  I   I        L++  + I D               +P E + N   II +
Sbjct: 342 EGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITL 401

Query: 470 EL---SYNKIMYFPLGLC-ALDSLYYLSVN--GNYISEIPVDISFSKQLL-HLELSENKL 522
           ++   S  +    P  +  A+ S    S+N   N + EIP  +   K+++  ++LS NKL
Sbjct: 402 KILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKL 461

Query: 523 LIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQ 582
              S   C L  L +LDL  N +  +P  + +++ L  + L  N+F+  P  L  +  L+
Sbjct: 462 SFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLE 521

Query: 583 VLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTR 642
            + +S NQ+  +                            +++ +E L    ++   L +
Sbjct: 522 TILISNNQVGSVDPQ-------------------------KMKMMENLTTLDLQNNDLLQ 556

Query: 643 LPGELSNMTQLKELDISNNAIREIPR 668
           +P EL N   L+ L +  N  R +PR
Sbjct: 557 IPPELGNCVNLRTLLLDGNPFR-VPR 581



 Score =  169 bits (429), Expect = 8e-42
 Identities = 140/541 (25%), Positives = 255/541 (47%), Gaps = 48/541 (8%)

Query: 235 NIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTT 294
           ++ +L   NN +++   DL  L  L +L +  N+L  +P  +  L+ L+ LN+ +N+L  
Sbjct: 83  DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142

Query: 295 FPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKEL 354
            P+ +  L  L  L L  N ++ + +   +L NLE L + +N LT +      L  +  L
Sbjct: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202

Query: 355 QLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYI 414
            L+ N+L+ +  +I   + L+ L  + NLL+ IP +++    LE L L  NKL  LP++ 
Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF- 261

Query: 415 HKLNNLRKLHVNRNNMVKI-TDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSY 473
              + L++LHV  N +  +  + + HLN+I  L+   N +  VP EI   + + +++LS 
Sbjct: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSN 321

Query: 474 NKIMYFPLGLCALDSLYYLSVNGNYISEIPVDI---SFSKQLLHLE-------------L 517
           N I   P  L  L  L +L++ GN +  I  +I      + L +L               
Sbjct: 322 NDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESA 380

Query: 518 SENKLLIFSE---HFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574
           +E  + + SE   +  ++I LK LD    Q   IP  + + +  +++             
Sbjct: 381 TETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTS----------- 429

Query: 575 LCTLENLQVLDLSENQLQKISSDICNLKG-IQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633
                    ++ S+NQL +I   +  LK  +  ++ S N+     +ELC LQ L  L++ 
Sbjct: 430 ---------INFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDL- 479

Query: 634 QIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSL 693
             +   L  LP E+ ++ +L+ +++S N  + +P  +  +  L ++   NNQ+  + P  
Sbjct: 480 --RNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQK 537

Query: 694 LSL-NDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYL 752
           + +  +L  L+L  N+L  +P  + N  +L+ +  D NP   P   I   K    I  YL
Sbjct: 538 MKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILM-KGTAAILEYL 596

Query: 753 Q 753
           +
Sbjct: 597 R 597



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 58/175 (33%), Positives = 95/175 (54%), Gaps = 5/175 (2%)

Query: 580 NLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRK 639
           +L  L +S N+LQ ++ D+  L  +  L+   NQ    P  + +L++L++LN+S     K
Sbjct: 83  DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSH---NK 139

Query: 640 LTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDL 699
           L  LP E++N+  LK L + +N +  I     +L NL  L   NN ++ +P S  SL+ L
Sbjct: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSL 199

Query: 700 QQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQR 754
            +LNLS N L +LP+ I  +  LK ++ + N L   P E+   + L  +  YL+R
Sbjct: 200 VRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELL--YLRR 252



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 30/82 (36%), Positives = 48/82 (58%)

Query: 651 TQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLT 710
           T L +L ISNN ++ +  ++  L  L  L  ++NQ++ LP ++  L +LQ+LN+S N L 
Sbjct: 82  TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141

Query: 711 ALPSAIYNIFSLKEINFDDNPL 732
            LP  I N+ +LK +    N L
Sbjct: 142 ILPEEITNLRNLKCLYLQHNEL 163



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 38/125 (30%), Positives = 58/125 (46%), Gaps = 5/125 (4%)

Query: 629 QLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISY 688
           QLN+S   GR L+ +P  +  +      + + N          E  +L  L   NN++  
Sbjct: 40  QLNLS---GRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQS 96

Query: 689 LPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTI 748
           L   L  L  L  L++  N LT+LPSAI  + +L+++N   N L   P EI   + L  +
Sbjct: 97  LTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCL 156

Query: 749 ARYLQ 753
             YLQ
Sbjct: 157 --YLQ 159



 Score = 33.5 bits (75), Expect = 0.87
 Identities = 22/100 (22%), Positives = 48/100 (48%), Gaps = 2/100 (2%)

Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSL-P 204
           ++L    L   P+++  +  ++ + L  N+ K         +  LE + +  N + S+ P
Sbjct: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEV-LYRIFTLETILISNNQVGSVDP 535

Query: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
            +++++ NL  L++ +N +  IP E+    N+R L    N
Sbjct: 536 QKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 20/77 (25%), Positives = 35/77 (45%)

Query: 145 TVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLP 204
           T+NL     +  P+ + +I  ++ + +  NQ+ +        +  L  L LQ N L  +P
Sbjct: 499 TINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIP 558

Query: 205 SEIQLLHNLRILNVSHN 221
            E+    NLR L +  N
Sbjct: 559 PELGNCVNLRTLLLDGN 575


>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
          Length = 1302

 Score =  170 bits (431), Expect = 5e-42
 Identities = 118/396 (29%), Positives = 188/396 (47%), Gaps = 27/396 (6%)

Query: 351 IKELQLADNKLEVISHKIENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409
           +  L  +   LE +  +I  F + L  L LD N ++ +P+++  C  L  LSL DN LT 
Sbjct: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83

Query: 410 LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469
           LP  I  L NLR+L V++N                        I + P  IKNC+ +  +
Sbjct: 84  LPASIANLINLRELDVSKNG-----------------------IQEFPENIKNCKVLTIV 120

Query: 470 ELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHF 529
           E S N I   P G   L +L  L +N  ++  +P +     +L  LEL EN+L +  +  
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180

Query: 530 CSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589
             L  L+ LDLG N+  ++P  +  +  L    +  N+    P  + +L+ L  LD+S+N
Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240

Query: 590 QLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSN 649
            ++ +   I   + +Q L  SSN     P  +  L+++  L I +    +L  LP  +  
Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE---NQLMYLPDSIGG 297

Query: 650 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNL 709
           +  ++ELD S N +  +P +IG+L NL +  A +N +  LPP + S  ++  L L  N L
Sbjct: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357

Query: 710 TALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745
             LP  + ++  LK IN  DN L   P    K +QL
Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393



 Score =  154 bits (389), Expect = 3e-37
 Identities = 108/399 (27%), Positives = 190/399 (47%), Gaps = 24/399 (6%)

Query: 216 LNVSHNHISHIPKEISQLGN-IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274
           L+ SH  +  +PKEI      + +L+   N IE  P  L    +L  LSL  N L  +P 
Sbjct: 27  LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86

Query: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMD 334
           ++ +L  LR L++  N +  FP+ +     L  ++ + N IS LP    +L NL  L ++
Sbjct: 87  SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146

Query: 335 HNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC 394
              L FL     +L K++ L+L +N+L+++   +    +L  L L  N    +PE +   
Sbjct: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206

Query: 395 AMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT 454
           + L+   +  N+LT +P +I  L  L  L V++NN+  + + IS   N+  L  S N + 
Sbjct: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ 266

Query: 455 DVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514
            +P  I + + I  +++  N++MY P  +  L S+  L  + N +  +P  I        
Sbjct: 267 QLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG------- 319

Query: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574
                            L NL+      N ++++P  I +  ++ VL L  NK ET P E
Sbjct: 320 ----------------QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363

Query: 575 LCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613
           +  ++ L+V++LS+N+L+ +      L+ +  +  S NQ
Sbjct: 364 MGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402



 Score =  150 bits (378), Expect = 6e-36
 Identities = 119/424 (28%), Positives = 193/424 (45%), Gaps = 48/424 (11%)

Query: 145 TVNLEAKGLQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSL 203
           T++     L++ PK+I    K ++ LYLD NQI+        +   L  LSL +N L++L
Sbjct: 26  TLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP-KQLFNCQSLHKLSLPDNDLTTL 84

Query: 204 PSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILS 263
           P+ I  L NLR L+VS N I   P+ I     +  +    N I   P     L NL  L 
Sbjct: 85  PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLY 144

Query: 264 LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIR 323
           L    L  +P     L  L++L L  NQL   PK +  L +L  LDL  N  + +P+ + 
Sbjct: 145 LNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE 204

Query: 324 ELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNL 383
           +L  L+   MD N+LTF+   I  L ++  L ++ N +E++                   
Sbjct: 205 QLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE------------------ 246

Query: 384 LKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNI 443
                E IS C  L+ L LS N L +LP+ I  L N+  L ++ N ++ + D I      
Sbjct: 247 -----EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI------ 295

Query: 444 CSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503
                 G +I+           + +++ S+N++   P  +  L +L   + + NY+ ++P
Sbjct: 296 ------GGLIS-----------VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338

Query: 504 VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLIL 563
            +I   K +  L L  NKL    E    +  LK ++L  N++K +P S + +  L  + L
Sbjct: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWL 398

Query: 564 CCNK 567
             N+
Sbjct: 399 SDNQ 402



 Score =  138 bits (348), Expect = 2e-32
 Identities = 91/340 (26%), Positives = 169/340 (49%), Gaps = 7/340 (2%)

Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
           L    N I ++P ++ NCQ + K+ L  N +   P  +  L +L  L V+ N I E P +
Sbjct: 51  LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPEN 110

Query: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565
           I   K L  +E S N +    + F  L+NL  L L    ++ +PA+   +  L +L L  
Sbjct: 111 IKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRE 170

Query: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625
           N+ +  P+ +  L  L+ LDL  N+  ++   +  L G+++    +N+    P  +  L+
Sbjct: 171 NQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLK 230

Query: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685
            L  L++S+     +  +   +S    L++L +S+N+++++P  IG L+N+ +L    NQ
Sbjct: 231 QLTYLDVSK---NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287

Query: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745
           + YLP S+  L  +++L+ S N + ALPS+I  + +L+    D N L + P EI   K +
Sbjct: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347

Query: 746 YTIARYLQRADERDEKILE----KIFKIVANNITETNFEF 781
             +  +  + +   E++ +    K+  +  N +    F F
Sbjct: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSF 387


>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
          Length = 1371

 Score =  170 bits (431), Expect = 5e-42
 Identities = 118/396 (29%), Positives = 188/396 (47%), Gaps = 27/396 (6%)

Query: 351 IKELQLADNKLEVISHKIENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409
           +  L  +   LE +  +I  F + L  L LD N ++ +P+++  C  L  LSL DN LT 
Sbjct: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83

Query: 410 LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469
           LP  I  L NLR+L V++N                        I + P  IKNC+ +  +
Sbjct: 84  LPASIANLINLRELDVSKNG-----------------------IQEFPENIKNCKVLTIV 120

Query: 470 ELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHF 529
           E S N I   P G   L +L  L +N  ++  +P +     +L  LEL EN+L +  +  
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180

Query: 530 CSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589
             L  L+ LDLG N+  ++P  +  +  L    +  N+    P  + +L+ L  LD+S+N
Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240

Query: 590 QLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSN 649
            ++ +   I   + +Q L  SSN     P  +  L+++  L I +    +L  LP  +  
Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE---NQLMYLPDSIGG 297

Query: 650 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNL 709
           +  ++ELD S N +  +P +IG+L NL +  A +N +  LPP + S  ++  L L  N L
Sbjct: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357

Query: 710 TALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745
             LP  + ++  LK IN  DN L   P    K +QL
Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393



 Score =  154 bits (389), Expect = 3e-37
 Identities = 108/399 (27%), Positives = 190/399 (47%), Gaps = 24/399 (6%)

Query: 216 LNVSHNHISHIPKEISQLGN-IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274
           L+ SH  +  +PKEI      + +L+   N IE  P  L    +L  LSL  N L  +P 
Sbjct: 27  LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86

Query: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMD 334
           ++ +L  LR L++  N +  FP+ +     L  ++ + N IS LP    +L NL  L ++
Sbjct: 87  SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146

Query: 335 HNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC 394
              L FL     +L K++ L+L +N+L+++   +    +L  L L  N    +PE +   
Sbjct: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206

Query: 395 AMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT 454
           + L+   +  N+LT +P +I  L  L  L V++NN+  + + IS   N+  L  S N + 
Sbjct: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ 266

Query: 455 DVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514
            +P  I + + I  +++  N++MY P  +  L S+  L  + N +  +P  I        
Sbjct: 267 QLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG------- 319

Query: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574
                            L NL+      N ++++P  I +  ++ VL L  NK ET P E
Sbjct: 320 ----------------QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363

Query: 575 LCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613
           +  ++ L+V++LS+N+L+ +      L+ +  +  S NQ
Sbjct: 364 MGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402



 Score =  150 bits (378), Expect = 6e-36
 Identities = 119/424 (28%), Positives = 193/424 (45%), Gaps = 48/424 (11%)

Query: 145 TVNLEAKGLQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSL 203
           T++     L++ PK+I    K ++ LYLD NQI+        +   L  LSL +N L++L
Sbjct: 26  TLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP-KQLFNCQSLHKLSLPDNDLTTL 84

Query: 204 PSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILS 263
           P+ I  L NLR L+VS N I   P+ I     +  +    N I   P     L NL  L 
Sbjct: 85  PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLY 144

Query: 264 LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIR 323
           L    L  +P     L  L++L L  NQL   PK +  L +L  LDL  N  + +P+ + 
Sbjct: 145 LNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE 204

Query: 324 ELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNL 383
           +L  L+   MD N+LTF+   I  L ++  L ++ N +E++                   
Sbjct: 205 QLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE------------------ 246

Query: 384 LKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNI 443
                E IS C  L+ L LS N L +LP+ I  L N+  L ++ N ++ + D I      
Sbjct: 247 -----EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI------ 295

Query: 444 CSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503
                 G +I+           + +++ S+N++   P  +  L +L   + + NY+ ++P
Sbjct: 296 ------GGLIS-----------VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338

Query: 504 VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLIL 563
            +I   K +  L L  NKL    E    +  LK ++L  N++K +P S + +  L  + L
Sbjct: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWL 398

Query: 564 CCNK 567
             N+
Sbjct: 399 SDNQ 402



 Score =  138 bits (348), Expect = 2e-32
 Identities = 91/340 (26%), Positives = 169/340 (49%), Gaps = 7/340 (2%)

Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
           L    N I ++P ++ NCQ + K+ L  N +   P  +  L +L  L V+ N I E P +
Sbjct: 51  LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPEN 110

Query: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565
           I   K L  +E S N +    + F  L+NL  L L    ++ +PA+   +  L +L L  
Sbjct: 111 IKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRE 170

Query: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625
           N+ +  P+ +  L  L+ LDL  N+  ++   +  L G+++    +N+    P  +  L+
Sbjct: 171 NQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLK 230

Query: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685
            L  L++S+     +  +   +S    L++L +S+N+++++P  IG L+N+ +L    NQ
Sbjct: 231 QLTYLDVSK---NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287

Query: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745
           + YLP S+  L  +++L+ S N + ALPS+I  + +L+    D N L + P EI   K +
Sbjct: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347

Query: 746 YTIARYLQRADERDEKILE----KIFKIVANNITETNFEF 781
             +  +  + +   E++ +    K+  +  N +    F F
Sbjct: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSF 387


>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
          Length = 1537

 Score =  160 bits (406), Expect = 4e-39
 Identities = 101/355 (28%), Positives = 176/355 (49%), Gaps = 23/355 (6%)

Query: 190 LEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENF 249
           LE L L  N +  LP ++     LR L++  N +S++P  I+ L N+++L    N ++ F
Sbjct: 48  LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107

Query: 250 PSDLECLGNLEILSLGKNKLRHIPD-------------------TLPS----LKTLRVLN 286
           P +++C   L I+    N +  +PD                    LP+    L  LR+L 
Sbjct: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILE 167

Query: 287 LEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIF 346
           L  N L T PK++  L +L  LDL  N    LP+ + +++NL  L MD+N L  L   I 
Sbjct: 168 LRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIG 227

Query: 347 QLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNK 406
           +L  +  L ++ N++E +   I     L  L+L  N+L+ +P+ I     L  L + DN+
Sbjct: 228 KLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQ 287

Query: 407 LTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466
           LT LP  I  L+ L +   + N +  +   I +L+++ +L    N + ++P EI +C+ +
Sbjct: 288 LTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNV 347

Query: 467 IKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENK 521
             + L  NK+ + P  +  +  L  L+++ N +  +P   +  K+L  L LS+N+
Sbjct: 348 TVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402



 Score =  159 bits (403), Expect = 8e-39
 Identities = 108/363 (29%), Positives = 178/363 (49%), Gaps = 4/363 (1%)

Query: 384 LKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442
           L+ +P+++ +    LE L L  N++ ELPK +     LRKL +  N++  +   I+ L N
Sbjct: 34  LQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93

Query: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502
           +  L+ S N + + P  IK C+ +  IE S N I   P G   L +L  L +N  ++  +
Sbjct: 94  LKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFL 153

Query: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562
           P +     +L  LEL EN L    +    L  L+ LDLG N+  ++P  +  + +L  L 
Sbjct: 154 PANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELW 213

Query: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622
           +  N  +  P  +  L+ L  LD+S+N+++ +  DI   + ++ L  SSN     P  + 
Sbjct: 214 MDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIG 273

Query: 623 QLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY 682
            L+ L  L +      +LT LP  + N++ L+E D S N +  +P  IG L +L +L   
Sbjct: 274 LLKKLTTLKVDD---NQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVD 330

Query: 683 NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKG 742
            N +  LP  + S  ++  ++L  N L  LP  I  +  L+ +N  DN L   P    K 
Sbjct: 331 ENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKL 390

Query: 743 KQL 745
           K+L
Sbjct: 391 KEL 393



 Score =  155 bits (393), Expect = 1e-37
 Identities = 114/402 (28%), Positives = 192/402 (47%), Gaps = 24/402 (5%)

Query: 213 LRILNVSHNHISHIPKEISQLGN-IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271
           + +L+ SH  +  +PKE+      + +L+   N IE  P  L     L  LS+  N L +
Sbjct: 24  ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83

Query: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331
           +P T+ SL  L+ L++  N +  FP+ +     L  ++ + N IS LP    +L NL  L
Sbjct: 84  LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143

Query: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKI 391
            ++   L FL     +L+K                       LRIL L +N LK +P+ +
Sbjct: 144 YLNDAFLEFLPANFGRLVK-----------------------LRILELRENHLKTLPKSM 180

Query: 392 SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGN 451
              A LE L L +N+  ELP+ + ++ NLR+L ++ N +  +   I  L  +  L+ S N
Sbjct: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240

Query: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQ 511
            I  V ++I  C+ +  + LS N +   P  +  L  L  L V+ N ++ +P  I     
Sbjct: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300

Query: 512 LLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETF 571
           L   + S N+L         L +L+ L + +N + ++P  I +  ++ V+ L  NK E  
Sbjct: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL 360

Query: 572 PRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613
           P E+  ++ L+VL+LS+N+L+ +      LK +  L  S NQ
Sbjct: 361 PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402



 Score =  135 bits (341), Expect = 1e-31
 Identities = 94/367 (25%), Positives = 186/367 (50%), Gaps = 7/367 (1%)

Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
           L    N I ++P ++ NCQ + K+ +  N +   P  + +L +L  L ++ N + E P +
Sbjct: 51  LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPEN 110

Query: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565
           I   K L  +E S N +    + F  L+NL  L L    ++ +PA+   ++ L +L L  
Sbjct: 111 IKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRE 170

Query: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625
           N  +T P+ +  L  L+ LDL  N+  ++   +  ++ +++L   +N     P  + +L+
Sbjct: 171 NHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLK 230

Query: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685
            L  L++S+    ++  +  ++S    L++L +S+N ++++P +IG L+ L +L   +NQ
Sbjct: 231 MLVYLDMSK---NRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQ 287

Query: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745
           ++ LP ++ +L+ L++ + S N L +LPS I  + SL+ +  D+N L   P EI   K +
Sbjct: 288 LTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNV 347

Query: 746 YTIARYLQRADERDEKILE----KIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTV 801
             ++    + +   E+I +    ++  +  N +    F F   K   A   +D  +K+ +
Sbjct: 348 TVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALI 407

Query: 802 SLSERAH 808
            L   AH
Sbjct: 408 PLQTEAH 414



 Score =  135 bits (339), Expect = 2e-31
 Identities = 97/378 (25%), Positives = 174/378 (46%), Gaps = 27/378 (7%)

Query: 308 LDLTGNLISSLPKEIREL-KNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISH 366
           LD +   +  +PKE+    + LE L +D N++  L  ++F    +++L + DN L  +  
Sbjct: 27  LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86

Query: 367 KIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVN 426
            I +   L+ L + KN ++  PE I CC  L  +  S N +++LP    +L NL +L++N
Sbjct: 87  TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146

Query: 427 -----------------------RNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNC 463
                                   N++  +   +  L  +  L+   N   ++P  +   
Sbjct: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQI 206

Query: 464 QKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLL 523
           Q + ++ +  N +   P  +  L  L YL ++ N I  + +DIS  + L  L LS N L 
Sbjct: 207 QNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQ 266

Query: 524 IFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQV 583
              +    L  L  L +  NQ+  +P +I N+  L      CN+ E+ P  +  L +L+ 
Sbjct: 267 QLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRT 326

Query: 584 LDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRL 643
           L + EN L ++  +I + K +  ++  SN+    P E+ Q+Q L  LN+S     +L  L
Sbjct: 327 LAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSD---NRLKNL 383

Query: 644 PGELSNMTQLKELDISNN 661
           P   + + +L  L +S+N
Sbjct: 384 PFSFTKLKELAALWLSDN 401



 Score =  123 bits (308), Expect = 8e-28
 Identities = 90/306 (29%), Positives = 139/306 (45%), Gaps = 45/306 (14%)

Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKT----------------------FQGAD 183
           +++   G+QEFP++I   K +  +    N I                        F  A+
Sbjct: 97  LDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPAN 156

Query: 184 SGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYN 243
            G L+ L IL L+EN L +LP  +  L  L  L++ +N    +P+ + Q+ N+R+L+  N
Sbjct: 157 FGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDN 216

Query: 244 NYIENFPSDLECLGNLEILSLGKNK-----------------------LRHIPDTLPSLK 280
           N ++  P  +  L  L  L + KN+                       L+ +PD++  LK
Sbjct: 217 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLK 276

Query: 281 TLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTF 340
            L  L ++ NQLT  P  +  L  L   D + N + SLP  I  L +L TL +D N L  
Sbjct: 277 KLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPE 336

Query: 341 LAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECL 400
           L  EI     +  + L  NKLE +  +I   ++LR+L L  N LKN+P   +    L  L
Sbjct: 337 LPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAAL 396

Query: 401 SLSDNK 406
            LSDN+
Sbjct: 397 WLSDNQ 402



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 71/248 (28%), Positives = 112/248 (45%), Gaps = 32/248 (12%)

Query: 117 LSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQI 176
           L +   GE+ P+V ++ Q    L  DN         LQ  P  I K+K + YL + KN+I
Sbjct: 191 LGNNEFGEL-PEVLDQIQNLRELWMDN-------NALQVLPGSIGKLKMLVYLDMSKNRI 242

Query: 177 KTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNI 236
           +T     SG    LE L L  N L  LP  I LL  L  L V  N ++ +P  I  L  +
Sbjct: 243 ETVDMDISG-CEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLL 301

Query: 237 RQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFP 296
            +     N +E+ PS +  L +L  L++ +N L  +P  + S K + V++L  N+L    
Sbjct: 302 EEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKL---- 357

Query: 297 KALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQL 356
                                LP+EI +++ L  L +  N+L  L     +L ++  L L
Sbjct: 358 -------------------EFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWL 398

Query: 357 ADNKLEVI 364
           +DN+ + +
Sbjct: 399 SDNQSKAL 406


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score =  156 bits (394), Expect = 9e-38
 Identities = 108/380 (28%), Positives = 196/380 (51%), Gaps = 5/380 (1%)

Query: 307 SLDLTGNLISSLPKEI-RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365
           S+D     + ++P+EI R  ++LE LL+D N+L  L    F+LL +++L L+DN+++ + 
Sbjct: 16  SVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLP 75

Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425
            ++ NF +L  L + +N +  IPE I  C  LE    S N L+ LP    +L +L  L +
Sbjct: 76  PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL 135

Query: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA 485
           N  ++  +   + +L N+ +LE   N++  +P  +    K+ +++L  N +   P  L A
Sbjct: 136 NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195

Query: 486 LDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQI 545
           L +L  L ++ N +S +P ++   ++L+ L++SEN+L         L+ L  L L +N +
Sbjct: 196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255

Query: 546 KKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQ 605
           +++P  I  +  L +L +  N+       +   ENL  L L+EN L  +   +  L  + 
Sbjct: 256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLT 315

Query: 606 KLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIRE 665
            LN   N     P E   +     L++  ++  +L  LP EL++ T+L  LD++ N ++ 
Sbjct: 316 NLNVDRNHLEALPPE---IGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQS 372

Query: 666 IPRNIGELRNLVSLHAYNNQ 685
           +P  +  L NL +L    NQ
Sbjct: 373 LPFALTHL-NLKALWLAENQ 391



 Score =  155 bits (393), Expect = 1e-37
 Identities = 108/354 (30%), Positives = 178/354 (50%), Gaps = 4/354 (1%)

Query: 384 LKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442
           L+ +PE+I      LE L L  N+L ELPK   +L NLRKL ++ N + ++   +++   
Sbjct: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83

Query: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502
           +  L+ S N I ++P  IK C+ +   + S N +   P G   L SL +L++N   +  +
Sbjct: 84  LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143

Query: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562
           P D+     L+ LEL EN L         L+ L+ LDLG N ++ +P ++  + +L  L 
Sbjct: 144 PGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELW 203

Query: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622
           L  N+    P EL  L  L  LD+SEN+L+++ +++  L  +  L  S N     P  + 
Sbjct: 204 LDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIG 263

Query: 623 QLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY 682
           QL+ L  L + Q +  ++T   G+  N   L EL ++ N +  +PR++G+L  L +L+  
Sbjct: 264 QLKQLSILKVDQNRLCEVTEAIGDCEN---LSELILTENLLMALPRSLGKLTKLTNLNVD 320

Query: 683 NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736
            N +  LPP +     L  L+L  N L  LP  + +   L  ++   N L   P
Sbjct: 321 RNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374



 Score =  154 bits (388), Expect = 4e-37
 Identities = 112/404 (27%), Positives = 194/404 (48%), Gaps = 25/404 (6%)

Query: 190 LEILSLQENGLSSLPSEI-QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIEN 248
           +E +  +   L ++P EI +   +L  L +  N +  +PK   +L N+R+L   +N I+ 
Sbjct: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73

Query: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308
            P ++     L  L + +N +  IP+++   K L + +   N L+  P     L  L  L
Sbjct: 74  LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133

Query: 309 DLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368
            L    + +LP ++  L NL TL +  N L  L   +  L+K+++L L  N LEV+   +
Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193

Query: 369 ENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
                LR L LD+N L  +P ++     L CL +S+N+L ELP  +  L  L  L +++N
Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253

Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
            + ++ D I  L  +  L+   N + +V   I +C+ + ++ L+ N +M  P  L  L  
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313

Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
           L  L+V+ N++  +P +I     L  L L +N+L +                       +
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV-----------------------L 350

Query: 549 PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQ 592
           P  +++   LHVL +  N+ ++ P  L  L NL+ L L+ENQ Q
Sbjct: 351 PPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393



 Score =  152 bits (385), Expect = 1e-36
 Identities = 108/356 (30%), Positives = 172/356 (48%), Gaps = 1/356 (0%)

Query: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317
           +LE L L  N+LR +P     L  LR L L  N++   P  +    +L+ LD++ N I  
Sbjct: 37  SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96

Query: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377
           +P+ I+  K LE      N L+ L     QL  +  L L D  L+ +   + N   L  L
Sbjct: 97  IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL 156

Query: 378 ILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCI 437
            L +NLLK++P  +S    LE L L  N L  LP  +  L NLR+L ++RN +  +   +
Sbjct: 157 ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216

Query: 438 SHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497
            +L  +  L+ S N + ++P E+     +  + LS N +   P G+  L  L  L V+ N
Sbjct: 217 GNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQN 276

Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
            + E+   I   + L  L L+EN L+        L  L  L++ +N ++ +P  I   ++
Sbjct: 277 RLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336

Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613
           L VL L  N+    P EL     L VLD++ N+LQ +   + +L  ++ L  + NQ
Sbjct: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391



 Score =  147 bits (370), Expect = 5e-35
 Identities = 109/370 (29%), Positives = 177/370 (47%), Gaps = 3/370 (0%)

Query: 153 LQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLH 211
           LQ  P++I +  + ++ L LD NQ++         LL L  L L +N +  LP E+    
Sbjct: 24  LQAVPEEIYRYSRSLEELLLDANQLRELP-KPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82

Query: 212 NLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271
            L  L+VS N I  IP+ I     +    F  N +   P     L +L  L+L    L+ 
Sbjct: 83  QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA 142

Query: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331
           +P  + +L  L  L L  N L + P +L FL KL  LDL GN +  LP  +  L NL  L
Sbjct: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202

Query: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKI 391
            +D N+L+ L  E+  L ++  L +++N+LE +  ++     L  L+L +NLL+ +P+ I
Sbjct: 203 WLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGI 262

Query: 392 SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGN 451
                L  L +  N+L E+ + I    NL +L +  N ++ +   +  L  + +L    N
Sbjct: 263 GQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRN 322

Query: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQ 511
            +  +P EI  C  +  + L  N++   P  L     L+ L V GN +  +P  ++    
Sbjct: 323 HLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALT-HLN 381

Query: 512 LLHLELSENK 521
           L  L L+EN+
Sbjct: 382 LKALWLAENQ 391



 Score =  103 bits (258), Expect = 5e-22
 Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 4/248 (1%)

Query: 499 ISEIPVDI-SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
           +  +P +I  +S+ L  L L  N+L    + F  L+NL+ L L  N+I+++P  ++N + 
Sbjct: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83

Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
           L  L +  N     P  +   + L++ D S N L ++      L+ +  L  +       
Sbjct: 84  LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143

Query: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLV 677
           P ++  L +L  L   +++   L  LP  LS + +L++LD+  N +  +P  +G L NL 
Sbjct: 144 PGDVGNLANLVTL---ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200

Query: 678 SLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPV 737
            L    NQ+S LPP L +L  L  L++S N L  LP+ +  +  L ++    N L R P 
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260

Query: 738 EICKGKQL 745
            I + KQL
Sbjct: 261 GIGQLKQL 268



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 61/201 (30%), Positives = 106/201 (52%), Gaps = 3/201 (1%)

Query: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616
           SL  L+L  N+    P+    L NL+ L LS+N++Q++  ++ N   + +L+ S N    
Sbjct: 37  SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96

Query: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676
            P  +   ++LE   I+   G  L+RLP   + +  L  L +++ +++ +P ++G L NL
Sbjct: 97  IPESIKFCKALE---IADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANL 153

Query: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736
           V+L    N +  LP SL  L  L+QL+L GN+L  LP  +  + +L+E+  D N L   P
Sbjct: 154 VTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALP 213

Query: 737 VEICKGKQLYTIARYLQRADE 757
            E+   ++L  +     R +E
Sbjct: 214 PELGNLRRLVCLDVSENRLEE 234


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score =  156 bits (394), Expect = 9e-38
 Identities = 108/380 (28%), Positives = 196/380 (51%), Gaps = 5/380 (1%)

Query: 307 SLDLTGNLISSLPKEI-RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365
           S+D     + ++P+EI R  ++LE LL+D N+L  L    F+LL +++L L+DN+++ + 
Sbjct: 16  SVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLP 75

Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425
            ++ NF +L  L + +N +  IPE I  C  LE    S N L+ LP    +L +L  L +
Sbjct: 76  PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL 135

Query: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA 485
           N  ++  +   + +L N+ +LE   N++  +P  +    K+ +++L  N +   P  L A
Sbjct: 136 NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195

Query: 486 LDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQI 545
           L +L  L ++ N +S +P ++   ++L+ L++SEN+L         L+ L  L L +N +
Sbjct: 196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255

Query: 546 KKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQ 605
           +++P  I  +  L +L +  N+       +   ENL  L L+EN L  +   +  L  + 
Sbjct: 256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLT 315

Query: 606 KLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIRE 665
            LN   N     P E   +     L++  ++  +L  LP EL++ T+L  LD++ N ++ 
Sbjct: 316 NLNVDRNHLEALPPE---IGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQS 372

Query: 666 IPRNIGELRNLVSLHAYNNQ 685
           +P  +  L NL +L    NQ
Sbjct: 373 LPFALTHL-NLKALWLAENQ 391



 Score =  155 bits (393), Expect = 1e-37
 Identities = 108/354 (30%), Positives = 178/354 (50%), Gaps = 4/354 (1%)

Query: 384 LKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442
           L+ +PE+I      LE L L  N+L ELPK   +L NLRKL ++ N + ++   +++   
Sbjct: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83

Query: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502
           +  L+ S N I ++P  IK C+ +   + S N +   P G   L SL +L++N   +  +
Sbjct: 84  LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143

Query: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562
           P D+     L+ LEL EN L         L+ L+ LDLG N ++ +P ++  + +L  L 
Sbjct: 144 PGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELW 203

Query: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622
           L  N+    P EL  L  L  LD+SEN+L+++ +++  L  +  L  S N     P  + 
Sbjct: 204 LDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIG 263

Query: 623 QLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY 682
           QL+ L  L + Q +  ++T   G+  N   L EL ++ N +  +PR++G+L  L +L+  
Sbjct: 264 QLKQLSILKVDQNRLCEVTEAIGDCEN---LSELILTENLLMALPRSLGKLTKLTNLNVD 320

Query: 683 NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736
            N +  LPP +     L  L+L  N L  LP  + +   L  ++   N L   P
Sbjct: 321 RNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374



 Score =  154 bits (388), Expect = 4e-37
 Identities = 112/404 (27%), Positives = 194/404 (48%), Gaps = 25/404 (6%)

Query: 190 LEILSLQENGLSSLPSEI-QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIEN 248
           +E +  +   L ++P EI +   +L  L +  N +  +PK   +L N+R+L   +N I+ 
Sbjct: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73

Query: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308
            P ++     L  L + +N +  IP+++   K L + +   N L+  P     L  L  L
Sbjct: 74  LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133

Query: 309 DLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368
            L    + +LP ++  L NL TL +  N L  L   +  L+K+++L L  N LEV+   +
Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193

Query: 369 ENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
                LR L LD+N L  +P ++     L CL +S+N+L ELP  +  L  L  L +++N
Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253

Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
            + ++ D I  L  +  L+   N + +V   I +C+ + ++ L+ N +M  P  L  L  
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313

Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
           L  L+V+ N++  +P +I     L  L L +N+L +                       +
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV-----------------------L 350

Query: 549 PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQ 592
           P  +++   LHVL +  N+ ++ P  L  L NL+ L L+ENQ Q
Sbjct: 351 PPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393



 Score =  152 bits (385), Expect = 1e-36
 Identities = 108/356 (30%), Positives = 172/356 (48%), Gaps = 1/356 (0%)

Query: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317
           +LE L L  N+LR +P     L  LR L L  N++   P  +    +L+ LD++ N I  
Sbjct: 37  SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96

Query: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377
           +P+ I+  K LE      N L+ L     QL  +  L L D  L+ +   + N   L  L
Sbjct: 97  IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL 156

Query: 378 ILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCI 437
            L +NLLK++P  +S    LE L L  N L  LP  +  L NLR+L ++RN +  +   +
Sbjct: 157 ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216

Query: 438 SHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497
            +L  +  L+ S N + ++P E+     +  + LS N +   P G+  L  L  L V+ N
Sbjct: 217 GNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQN 276

Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
            + E+   I   + L  L L+EN L+        L  L  L++ +N ++ +P  I   ++
Sbjct: 277 RLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336

Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613
           L VL L  N+    P EL     L VLD++ N+LQ +   + +L  ++ L  + NQ
Sbjct: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391



 Score =  147 bits (370), Expect = 5e-35
 Identities = 109/370 (29%), Positives = 177/370 (47%), Gaps = 3/370 (0%)

Query: 153 LQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLH 211
           LQ  P++I +  + ++ L LD NQ++         LL L  L L +N +  LP E+    
Sbjct: 24  LQAVPEEIYRYSRSLEELLLDANQLRELP-KPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82

Query: 212 NLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271
            L  L+VS N I  IP+ I     +    F  N +   P     L +L  L+L    L+ 
Sbjct: 83  QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA 142

Query: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331
           +P  + +L  L  L L  N L + P +L FL KL  LDL GN +  LP  +  L NL  L
Sbjct: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202

Query: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKI 391
            +D N+L+ L  E+  L ++  L +++N+LE +  ++     L  L+L +NLL+ +P+ I
Sbjct: 203 WLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGI 262

Query: 392 SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGN 451
                L  L +  N+L E+ + I    NL +L +  N ++ +   +  L  + +L    N
Sbjct: 263 GQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRN 322

Query: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQ 511
            +  +P EI  C  +  + L  N++   P  L     L+ L V GN +  +P  ++    
Sbjct: 323 HLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALT-HLN 381

Query: 512 LLHLELSENK 521
           L  L L+EN+
Sbjct: 382 LKALWLAENQ 391



 Score =  103 bits (258), Expect = 5e-22
 Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 4/248 (1%)

Query: 499 ISEIPVDI-SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
           +  +P +I  +S+ L  L L  N+L    + F  L+NL+ L L  N+I+++P  ++N + 
Sbjct: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83

Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
           L  L +  N     P  +   + L++ D S N L ++      L+ +  L  +       
Sbjct: 84  LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143

Query: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLV 677
           P ++  L +L  L   +++   L  LP  LS + +L++LD+  N +  +P  +G L NL 
Sbjct: 144 PGDVGNLANLVTL---ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200

Query: 678 SLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPV 737
            L    NQ+S LPP L +L  L  L++S N L  LP+ +  +  L ++    N L R P 
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260

Query: 738 EICKGKQL 745
            I + KQL
Sbjct: 261 GIGQLKQL 268



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 61/201 (30%), Positives = 106/201 (52%), Gaps = 3/201 (1%)

Query: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616
           SL  L+L  N+    P+    L NL+ L LS+N++Q++  ++ N   + +L+ S N    
Sbjct: 37  SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96

Query: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676
            P  +   ++LE   I+   G  L+RLP   + +  L  L +++ +++ +P ++G L NL
Sbjct: 97  IPESIKFCKALE---IADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANL 153

Query: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736
           V+L    N +  LP SL  L  L+QL+L GN+L  LP  +  + +L+E+  D N L   P
Sbjct: 154 VTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALP 213

Query: 737 VEICKGKQLYTIARYLQRADE 757
            E+   ++L  +     R +E
Sbjct: 214 PELGNLRRLVCLDVSENRLEE 234


>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
           [Homo sapiens]
          Length = 1052

 Score =  155 bits (392), Expect = 2e-37
 Identities = 108/358 (30%), Positives = 179/358 (50%), Gaps = 30/358 (8%)

Query: 397 LECLSLSDNKLTELPKYIHK-LNNLRKLHVNRNNMVKITDCISHL-NNICSLEFSGNIIT 454
           +E L+L +N L E+P+ +   L +LR L + RN   ++   ++ L +++  L+ S N +T
Sbjct: 65  IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124

Query: 455 DVPIEIKNC-QKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLL 513
            +  E+ +  +++ K+ LS+N++   P  L AL  L  L V+ N ++ +P  +S   +L 
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184

Query: 514 HLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPR 573
            L++  N+L  F      L+ L+ LD+  N+++ +P  IS + +L +L L   +  T P 
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244

Query: 574 ELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633
             C L +L+ L L  N LQ + +    L+ ++ LN SSN F  FP  L  L  LE     
Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLE----- 299

Query: 634 QIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSL 693
                                EL +S N +  +P  I  L  L++L   NN+I YLP S+
Sbjct: 300 ---------------------ELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSI 338

Query: 694 LSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARY 751
           + L  L++L L GN +  LP     +  +      DNPL++PP E+C  K +  IA Y
Sbjct: 339 VELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCM-KGIPYIAAY 395



 Score =  145 bits (366), Expect = 2e-34
 Identities = 101/333 (30%), Positives = 167/333 (50%), Gaps = 17/333 (5%)

Query: 185 GDLLG-LEILSLQENGLSSLPSEI-QLLHNLRILNVSHNHISHIPKEI-SQLGNIRQLFF 241
           G  LG L +L L+ N  + LP  + +L H+L  L+VSHN ++ +  E+ S L  +R+L  
Sbjct: 83  GSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNL 142

Query: 242 YNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF 301
            +N +   P+ L  L +LE L +  N+L H+PD+L  L  LR L++++NQLT FP+ L  
Sbjct: 143 SHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQ 202

Query: 302 LPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKL 361
           L  L  LD++ N +  LP++I  L+ L+ L +   +L  L     +L  ++ L L +N L
Sbjct: 203 LVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGL 262

Query: 362 EVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLR 421
           + +  +    + L++L L  NL +  P  +   A LE L LS N+LT +P  I  L  L 
Sbjct: 263 QALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLL 322

Query: 422 KLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPL 481
            L ++ N +  + D I  L  +  L   GN I  +P       ++   ++  N ++  P 
Sbjct: 323 TLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPY 382

Query: 482 GLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514
            +C              +  IP   ++ K+L H
Sbjct: 383 EVC--------------MKGIPYIAAYQKELAH 401



 Score =  124 bits (311), Expect = 4e-28
 Identities = 94/346 (27%), Positives = 173/346 (50%), Gaps = 7/346 (2%)

Query: 351 IKELQLADNKLEVISHKIEN-FRELRILILDKNLLKNIPEKISCCAM-LECLSLSDNKLT 408
           I+ L L +N LE +   + +    LR+L+L +N    +P  ++     L  L +S N+LT
Sbjct: 65  IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124

Query: 409 EL-PKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKII 467
            L  + +  L  LRKL+++ N +  +   +  L ++  L+ S N +  +P  +    ++ 
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184

Query: 468 KIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE 527
            +++ +N++  FP  L  L +L  L V+ N +  +P DIS  + L  L LS  +L     
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244

Query: 528 HFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLS 587
            FC L +L+ L L  N ++ +PA  S +  L +L L  N FE FP  L  L  L+ L LS
Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304

Query: 588 ENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGEL 647
            NQL  + S I  L  +  L   +N+  + P  + +L  LE+L    ++G ++  LP   
Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEEL---VLQGNQIAVLPDHF 361

Query: 648 SNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSL 693
             ++++    I +N + + P  +  ++ +  + AY  ++++  P++
Sbjct: 362 GQLSRVGLWKIKDNPLIQPPYEVC-MKGIPYIAAYQKELAHSQPAV 406



 Score =  121 bits (303), Expect = 3e-27
 Identities = 104/368 (28%), Positives = 156/368 (42%), Gaps = 45/368 (12%)

Query: 256 LGNLEILSLGKNKLRHIPDTLPS-LKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL 314
           LG++E L+LG N L  +P+ L S L +LRVL L  N+    P A                
Sbjct: 62  LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPA---------------- 105

Query: 315 ISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFREL 374
           ++ L   + EL       + HN+LT L  E+   L                      REL
Sbjct: 106 VAELGHHLTELD------VSHNRLTALGAEVVSAL----------------------REL 137

Query: 375 RILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKIT 434
           R L L  N L  +P ++   A LE L +S N+L  LP  +  L+ LR L V+ N +    
Sbjct: 138 RKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFP 197

Query: 435 DCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSV 494
             +  L  +  L+ S N +  +P +I   + +  + LS  ++   P G C L SL  L +
Sbjct: 198 RQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLML 257

Query: 495 NGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN 554
           + N +  +P   S  ++L  L LS N    F      L  L+ L L +NQ+  +P+ IS 
Sbjct: 258 DNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG 317

Query: 555 MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQF 614
           +  L  L L  N+    P  +  L  L+ L L  NQ+  +      L  +       N  
Sbjct: 318 LGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPL 377

Query: 615 IHFPIELC 622
           I  P E+C
Sbjct: 378 IQPPYEVC 385



 Score =  115 bits (287), Expect = 2e-25
 Identities = 92/346 (26%), Positives = 159/346 (45%), Gaps = 26/346 (7%)

Query: 210 LHNLRILNVSHNHISHIPKEI-SQLGNIRQLFFYNNYIENFPSDLECLGN-LEILSLGKN 267
           L ++  LN+ +N +  +P+ + S LG++R L    N     P  +  LG+ L  L +  N
Sbjct: 62  LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121

Query: 268 KLRHI-PDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326
           +L  +  + + +L+ LR LNL +NQL   P  L  L  L  LD++ N ++ LP  +  L 
Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLS 181

Query: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKN 386
            L TL +DHN+LT    ++ QL+ ++EL ++ N+L                       + 
Sbjct: 182 RLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRL-----------------------RG 218

Query: 387 IPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSL 446
           +PE IS    L+ L LS  +L  LP    +L +L  L ++ N +  +    S L  +  L
Sbjct: 219 LPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKML 278

Query: 447 EFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDI 506
             S N+  + P  +     + ++ LS N++   P  +  L  L  L ++ N I  +P  I
Sbjct: 279 NLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSI 338

Query: 507 SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASI 552
                L  L L  N++ +  +HF  L  +    +  N + + P  +
Sbjct: 339 VELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384



 Score =  102 bits (254), Expect = 2e-21
 Identities = 71/249 (28%), Positives = 116/249 (46%), Gaps = 1/249 (0%)

Query: 163 IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNH 222
           ++ ++ L L  NQ+     A  G L  LE L +  N L+ LP  +  L  LR L+V HN 
Sbjct: 134 LRELRKLNLSHNQLPALP-AQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQ 192

Query: 223 ISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTL 282
           ++  P+++ QL  + +L   +N +   P D+  L  L+IL L   +L  +P     L +L
Sbjct: 193 LTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASL 252

Query: 283 RVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLA 342
             L L+ N L   P     L +L  L+L+ NL    P  +  L  LE L +  N+LT + 
Sbjct: 253 ESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVP 312

Query: 343 VEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSL 402
             I  L ++  L L +N++  +   I     L  L+L  N +  +P+     + +    +
Sbjct: 313 SLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKI 372

Query: 403 SDNKLTELP 411
            DN L + P
Sbjct: 373 KDNPLIQPP 381



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 28/95 (29%), Positives = 55/95 (57%), Gaps = 3/95 (3%)

Query: 648 SNMTQLKELDISNNAIREIPRNIGE-LRNLVSLHAYNNQISYLPPSLLSL-NDLQQLNLS 705
           +N+  ++ L++ NN + E+P  +G  L +L  L    N+ + LPP++  L + L +L++S
Sbjct: 60  ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119

Query: 706 GNNLTALPSAIYN-IFSLKEINFDDNPLLRPPVEI 739
            N LTAL + + + +  L+++N   N L   P ++
Sbjct: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQL 154



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 3/138 (2%)

Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
           +NL +   +EFP  +L +  ++ LYL +NQ+ +     SG L  L  L L  N +  LP 
Sbjct: 278 LNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG-LGRLLTLWLDNNRIRYLPD 336

Query: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLG 265
            I  L  L  L +  N I+ +P    QL  +      +N +   P ++ C+  +  ++  
Sbjct: 337 SIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV-CMKGIPYIAAY 395

Query: 266 KNKLRHI-PDTLPSLKTL 282
           + +L H  P   P LK L
Sbjct: 396 QKELAHSQPAVQPRLKLL 413


>gi|4503743 flightless I homolog [Homo sapiens]
          Length = 1269

 Score =  144 bits (362), Expect = 5e-34
 Identities = 105/362 (29%), Positives = 180/362 (49%), Gaps = 25/362 (6%)

Query: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI 246
           +  L  L L   GL  LP E+  L  L  L+VSHN+++ +  E+S L ++R +    N +
Sbjct: 32  MTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSL 91

Query: 247 EN--FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF-LP 303
           +N   P D+  L +L +L L  N+L   P  L + K + VLNL +N + T P  L   L 
Sbjct: 92  KNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLT 151

Query: 304 KLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEV 363
            L+ LDL+ N + SLP ++R L +L+TL+++ N L  L  ++ QL  +  LQ        
Sbjct: 152 DLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPL--LHAQLRQLPAMTALQTLH----- 204

Query: 364 ISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKL 423
                        L   +    N+P  +   + L  + LS N LT +P+ ++ L +LR+L
Sbjct: 205 -------------LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRL 251

Query: 424 HVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMY--FPL 481
           +++ N + +++ CI    ++ +L  S N +T +P  I    K+ K+ L+ NK+ +   P 
Sbjct: 252 NLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPS 311

Query: 482 GLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLG 541
           G+  L +L       N +  +P  +    +L  L L++N L+   E    L  ++ LD+ 
Sbjct: 312 GIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVR 371

Query: 542 KN 543
           +N
Sbjct: 372 EN 373



 Score =  137 bits (345), Expect = 4e-32
 Identities = 110/379 (29%), Positives = 190/379 (50%), Gaps = 20/379 (5%)

Query: 388 PEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLE 447
           PE +     L  L L+   L  LP+ +  L  L  L V+ NN+  +   +S L ++ ++ 
Sbjct: 26  PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85

Query: 448 FSGNIITD--VPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
              N + +  VP +I     +  ++LS+N++   P  L    ++  L+++ N I  IP  
Sbjct: 86  ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145

Query: 506 ISFS-KQLLHLELSENKLLIFSEHFCSLINLKYLDLGKN-----QIKKIPASISNMISLH 559
           +  +   LL+L+LSEN+L         L++L+ L L  N     Q++++PA    M +L 
Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA----MTALQ 201

Query: 560 VLILCCNKF--ETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
            L L   +      P  L  L NL  +DLS N L ++   +  L  +++LN SSNQ    
Sbjct: 202 TLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITEL 261

Query: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR--EIPRNIGELRN 675
            + + Q   +E LN+S+    +LT LP  +  +++LK+L +++N +    +P  IG+L N
Sbjct: 262 SLCIDQWVHVETLNLSR---NQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTN 318

Query: 676 LVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNP-LLR 734
           L    A NN +  +P SL     L++L L+ N+L  LP AI+ +  ++ ++  +NP L+ 
Sbjct: 319 LEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVM 378

Query: 735 PPVEICKGKQLYTIARYLQ 753
           PP    +  + Y I   LQ
Sbjct: 379 PPKPADRAAEWYNIDFSLQ 397



 Score =  111 bits (278), Expect = 3e-24
 Identities = 84/275 (30%), Positives = 139/275 (50%), Gaps = 5/275 (1%)

Query: 142 DNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLS 201
           D   ++L    L E P+++   K +  L L  N I T       +L  L  L L EN L 
Sbjct: 105 DLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLE 164

Query: 202 SLPSEIQLLHNLRILNVSHNHISHIP-KEISQLGNIRQLFFYNNYI--ENFPSDLECLGN 258
           SLP +++ L +L+ L ++ N + H   +++  +  ++ L   +      N P+ LE L N
Sbjct: 165 SLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSN 224

Query: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSL 318
           L  + L  N L  +P+ L +L +LR LNL  NQ+T     +     + +L+L+ N ++SL
Sbjct: 225 LADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSL 284

Query: 319 PKEIRELKNLETLLMDHNKLTF--LAVEIFQLLKIKELQLADNKLEVISHKIENFRELRI 376
           P  I +L  L+ L ++ NKL F  L   I +L  ++E   A+N LE++   +    +LR 
Sbjct: 285 PSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRK 344

Query: 377 LILDKNLLKNIPEKISCCAMLECLSLSDNKLTELP 411
           L+L+KN L  +PE I     +E L + +N    +P
Sbjct: 345 LVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379


>gi|37221175 PH domain and leucine rich repeat protein phosphatase
           [Homo sapiens]
          Length = 1205

 Score =  133 bits (334), Expect = 8e-31
 Identities = 132/502 (26%), Positives = 238/502 (47%), Gaps = 33/502 (6%)

Query: 193 LSLQENGLSSLPS--------EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
           L+L++N L   PS        E+Q    L+ LN+S+NH+   P  +  +  + +L    N
Sbjct: 153 LNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCN 212

Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
            + + P+ +  + NL+   L  N L+ +P  L ++K L  L L +N+ T  P+ L  L  
Sbjct: 213 ALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTA 272

Query: 305 LISLDLTGNLISSLP----KEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360
           +  L ++GN + +L     +++  +K+++  L    KL  +A E+  L  + +L L DNK
Sbjct: 273 VDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKL--IADEVDFLQHVTQLDLRDNK 330

Query: 361 LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL 420
           L  +   I  F  + +L  ++N L  +     C   L+ L  S N+L +L  Y    N L
Sbjct: 331 LGDLDAMI--FNNIEVLHCERNQLVTLD---ICGYFLKALYASSNELVQLDVY-PVPNYL 384

Query: 421 RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP 480
             + V+RN +  + + +     +  L+   N I ++P  +     + K+   +N++   P
Sbjct: 385 SYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLP 444

Query: 481 LGLCALDSLYYLSVNGNYISEIPVDISF-SKQLLHLELSENKL-----LIFSEHFCSLIN 534
             L    S+  L V  N + E+P ++   +  L  L  S NKL        SE   S++ 
Sbjct: 445 ERL-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQ 503

Query: 535 LKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFP-RELCTLENLQVLDLSENQLQK 593
             YL       K +P  ++    L +L +  N+ ++FP  ++  LE L+ +DLS N+L+ 
Sbjct: 504 ELYLTNNSLTDKCVPL-LTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKA 562

Query: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQL 653
           I + I N + +  +   SN    FP E+ QL  ++ +++S  +  ++T LP  L    +L
Sbjct: 563 IPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVT-LPENLP--PKL 618

Query: 654 KELDISNNAIREIPRNIGELRN 675
           +ELD++ N    +     EL N
Sbjct: 619 QELDLTGNPRLVLDHKTLELLN 640



 Score =  131 bits (329), Expect = 3e-30
 Identities = 135/493 (27%), Positives = 225/493 (45%), Gaps = 80/493 (16%)

Query: 246 IENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLK---------TLRVLNLEYNQLTTFP 296
           +E+ P++L    +L  L+L +N LR  P +LP+ +          L+ LNL  N L  FP
Sbjct: 137 LEHLPANLFYSQDLTHLNLKQNFLRQNP-SLPAARGLNELQRFTKLKSLNLSNNHLGDFP 195

Query: 297 KALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQL 356
            A+C +P L  L+++ N + S+P  +  + NL+T L+D N L  L  E+           
Sbjct: 196 LAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAEL----------- 244

Query: 357 ADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHK 416
                       EN ++L  L L  N   +IPE +     ++ L +S N +  L     +
Sbjct: 245 ------------ENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETL-----R 287

Query: 417 LNNLRKL----HVN-RNNMVK--ITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469
           L  LRK+    HV+ R N+++  I D +  L ++  L+   N + D+   I N  +++  
Sbjct: 288 LQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHC 347

Query: 470 ELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHF 529
           E   N+++   +    L +LY  S     +   PV       L ++++S N+L    E  
Sbjct: 348 ER--NQLVTLDICGYFLKALYASSNELVQLDVYPVP----NYLSYMDVSRNRLENVPEWV 401

Query: 530 CSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589
           C    L+ LD+G NQI ++PA +    SL  L+   N+    P  L    +++VLD+  N
Sbjct: 402 CESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERL-ERTSVEVLDVQHN 460

Query: 590 QLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSN 649
           QL ++  ++                      L +  SL  LN S  K   L   P  LS 
Sbjct: 461 QLLELPPNL----------------------LMKADSLRFLNASANKLESLP--PATLSE 496

Query: 650 MTQ--LKELDISNNAIRE--IPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLS 705
            T   L+EL ++NN++ +  +P   G     +   AYN   S+    +  L +L++++LS
Sbjct: 497 ETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLS 556

Query: 706 GNNLTALPSAIYN 718
           GN L A+P+ I N
Sbjct: 557 GNKLKAIPTTIMN 569



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 91/398 (22%), Positives = 167/398 (41%), Gaps = 38/398 (9%)

Query: 412 KYIHKLNNLRKLHVNRNNMVKITDC-ISHL-------NNICSLEFSGNIITDVPI----- 458
           +Y+  L  + K+   R + V ++ C + HL        ++  L    N +   P      
Sbjct: 111 EYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAAR 170

Query: 459 ---EIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHL 515
              E++   K+  + LS N +  FPL +C++ +L  L+V+ N +  +P  +     L   
Sbjct: 171 GLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTF 230

Query: 516 ELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE- 574
            L  N L        ++  L YL L  N+   IP  +  + ++  L +  N  ET   + 
Sbjct: 231 LLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQA 290

Query: 575 LCTLENLQVLDLSENQLQKISSDICN-LKGIQKLNFSSNQ--------FIHFPIELCQLQ 625
           L  + +++ +DL  N ++K+ +D  + L+ + +L+   N+        F +  +  C+  
Sbjct: 291 LRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERN 350

Query: 626 SLEQLNISQIKGRKLTRLPGELSNM------TQLKELDISNNAIREIPRNIGELRNLVSL 679
            L  L+I     + L     EL  +        L  +D+S N +  +P  + E R L  L
Sbjct: 351 QLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVL 410

Query: 680 HAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLR-PPVE 738
              +NQI  LP  L   + L++L    N L  LP  +    S++ ++   N LL  PP  
Sbjct: 411 DIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLERT-SVEVLDVQHNQLLELPPNL 469

Query: 739 ICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITE 776
           + K   L    R+L  +  + E +         N+I +
Sbjct: 470 LMKADSL----RFLNASANKLESLPPATLSEETNSILQ 503



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 41/178 (23%), Positives = 75/178 (42%), Gaps = 17/178 (9%)

Query: 568 FETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIE------- 620
           F+TF   L  L   QV  ++  ++  +    C+L+ +    F S    H  ++       
Sbjct: 106 FDTFTEYLRWLR--QVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQN 163

Query: 621 --------LCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGE 672
                   L +LQ   +L    +    L   P  + ++  L EL++S NA+R +P  +G 
Sbjct: 164 PSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGV 223

Query: 673 LRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDN 730
           + NL +     N +  LP  L ++  L  L LS N  T +P  +  + ++ ++    N
Sbjct: 224 MHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGN 281


>gi|65301141 PH domain and leucine rich repeat protein
           phosphatase-like [Homo sapiens]
          Length = 1323

 Score =  131 bits (329), Expect = 3e-30
 Identities = 153/539 (28%), Positives = 255/539 (47%), Gaps = 42/539 (7%)

Query: 216 LNVSHNHISHIPKEISQLGNIRQLFFYNNYIE-NFPSDLECL---GNLEILSLGKNKLRH 271
           +++S   +  +P+ +    +I  L   +N+++   P  L+ L     L+ L+L  NKL  
Sbjct: 254 VDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGL 313

Query: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331
            P  L  + TL  LNL  N     P  +  L  L +L L GN +++LP+E+  L+ L +L
Sbjct: 314 FPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSL 373

Query: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN-FRELRILILDKNLLKN-IPE 389
            +  N  + +     +L  +  + +A N LEV++  + N    ++ + L  N LK  + E
Sbjct: 374 GISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIE 433

Query: 390 KISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFS 449
            +     +  + L DN+LT+L   +  L +L +LH  RN + ++T  +S  + + +L  S
Sbjct: 434 NLEGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELT--LSGFS-LRTLYAS 488

Query: 450 GNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFS 509
            N +T V +       +  ++LS N +   P   C    +  L V+ N ++E+PV I  S
Sbjct: 489 SNRLTAVNV-YPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSS 547

Query: 510 KQLLHLELSEN---KLLIFSEHFCSLINLKYLDLGKNQIKKIPASI-SNMISLHVLILCC 565
             L  L L  N    L    EH    I L+ LDL  N + ++P ++ S  ++L  L    
Sbjct: 548 LSLRKLMLGHNHVQNLPTLVEH----IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASA 603

Query: 566 NKFETFPRELCT----LENLQVLDLSENQL--QKISSDICNLKGIQKLNFSSNQFIHFPI 619
           N  E+ P   CT    L  LQ+L L+ N L  Q I   + +L  ++ L+ ++NQ   FP 
Sbjct: 604 NSLESLP-SACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPA 661

Query: 620 -ELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVS 678
            +L +L+ LE+LN+S   G KL  +P  ++N  +L  L   +N I   P    E+  L  
Sbjct: 662 SKLNKLEQLEELNLS---GNKLKTIPTTIANCKRLHTLVAHSNNISIFP----EILQLPQ 714

Query: 679 LH----AYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFS-LKEINFDDNPL 732
           +     + N+    L P  L    LQ L+L+GN    L     +IFS +  +  D  PL
Sbjct: 715 IQFVDLSCNDLTEILIPEALPAT-LQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPL 772



 Score =  122 bits (305), Expect = 2e-27
 Identities = 149/571 (26%), Positives = 250/571 (43%), Gaps = 48/571 (8%)

Query: 102 SLTGRTAEYQALVNFLSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDIL 161
           SL   +A  QA    +S ET+ E       + Q    +     TV+L    L+E P+ + 
Sbjct: 213 SLAFSSAGAQAQTYHVSFETLAEYQRW---QRQASKVVSQRISTVDLSCYSLEEVPEHLF 269

Query: 162 KIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHN 221
             + + YL L  N             + LE    +  GL +L    QL    + LN+SHN
Sbjct: 270 YSQDITYLNLRHN------------FMQLE----RPGGLDTLYKFSQL----KGLNLSHN 309

Query: 222 HISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKT 281
            +   P  + ++  + +L    N   + PS +  L NL+ L L  N L  +P+ L +L+ 
Sbjct: 310 KLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQ 369

Query: 282 LRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEI-RELKNLETLLMDHNKLTF 340
           L  L + +N  +  P+    L  L  + + GN +  L   +   + +++ + +  N L  
Sbjct: 370 LSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKT 429

Query: 341 LAVEIFQLLK-IKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLEC 399
           + +E  +  K I  + L DN+L  +   + +   L  L   +N L+   E       L  
Sbjct: 430 MVIENLEGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLR---ELTLSGFSLRT 484

Query: 400 LSLSDNKLTELPKY-IHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPI 458
           L  S N+LT +  Y +  L  L  L ++RN +  + D       I  L+ S N++T+VP+
Sbjct: 485 LYASSNRLTAVNVYPVPSL--LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPV 542

Query: 459 EIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSK--QLLHLE 516
            I +   + K+ L +N +   P  L     L  L +  N ++ +P D  FSK   L +L 
Sbjct: 543 RILSSLSLRKLMLGHNHVQNLPT-LVEHIPLEVLDLQHNALTRLP-DTLFSKALNLRYLN 600

Query: 517 LSENKL-----LIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETF 571
            S N L         E   S++ L YL       + IP  + + + L +L L  N+ +TF
Sbjct: 601 ASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGH-LHLRILHLANNQLQTF 659

Query: 572 P-RELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQL 630
           P  +L  LE L+ L+LS N+L+ I + I N K +  L   SN    FP    ++  L Q+
Sbjct: 660 PASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFP----EILQLPQI 715

Query: 631 NISQIKGRKLTRLPGELSNMTQLKELDISNN 661
               +    LT +    +    L++LD++ N
Sbjct: 716 QFVDLSCNDLTEILIPEALPATLQDLDLTGN 746



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 64/272 (23%), Positives = 108/272 (39%), Gaps = 35/272 (12%)

Query: 604 IQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNM---TQLKELDISN 660
           I  ++ S       P  L   Q +  LN+      +L R PG L  +   +QLK L++S+
Sbjct: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRH-NFMQLER-PGGLDTLYKFSQLKGLNLSH 308

Query: 661 NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF 720
           N +   P  + E+  L  L+   N    LP  + +L +LQ L L GN LT LP  + N+ 
Sbjct: 309 NKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQ 368

Query: 721 SLKEINFDDNPLLRPPVEICKGKQLYTIA-----------------RYLQRADERDEKIL 763
            L  +    N   + P    K   L  +                   +++  D R   + 
Sbjct: 369 QLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLK 428

Query: 764 EKIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSL 823
             + + +  N   T+ +    +L      TD+   S  SL +     L   + Q  +L+L
Sbjct: 429 TMVIENLEGNKHITHVDLRDNRL------TDLDLSSLCSLEQ-----LHCGRNQLRELTL 477

Query: 824 TAAALRDQLIRA--LTMIGAYEIMDKITALNL 853
           +  +LR     +  LT +  Y +   +T L+L
Sbjct: 478 SGFSLRTLYASSNRLTAVNVYPVPSLLTFLDL 509


>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
           sapiens]
          Length = 803

 Score =  115 bits (289), Expect = 1e-25
 Identities = 105/389 (26%), Positives = 186/389 (47%), Gaps = 38/389 (9%)

Query: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-N 258
           LS LP  +  +  L+ L +       IP  I+QL N+++L  +   ++   + L  L  N
Sbjct: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492

Query: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNL------EYNQLTTFPKALCFLPKLISLDLTG 312
           L++LS+  + +R +P  +  L+ L  L L      + ++  T  ++L  L  L  L +  
Sbjct: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTL-ESLRDLKSLKILSIKS 551

Query: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAV--EIFQLLKIKELQLADNKLEVISHKIEN 370
           N +S +P+ + ++ +    +  HN  T L +   + ++  + EL+L    LE I H + +
Sbjct: 552 N-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFS 610

Query: 371 FRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
              L+ L L +N LK+I E +S   +  L  L L  N +T +P++I KL +L +L     
Sbjct: 611 LLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERL----- 665

Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
                              FS N I  +P  +  C KI  ++LSYN I + P  +  L S
Sbjct: 666 ------------------SFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQS 707

Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
           L Y S+  N +  +P ++ F K+L  L++ +N L + S    +L+ L YLD+  N  + +
Sbjct: 708 LQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEIL 767

Query: 549 PASISNMISLH--VLILCCNKFETFPREL 575
           P  + +  +L    L++    FET P ++
Sbjct: 768 PPELGDCRALKRAGLVVEDALFETLPSDV 796



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 93/375 (24%), Positives = 161/375 (42%), Gaps = 36/375 (9%)

Query: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK-N 327
           L  +PDT+  +  L+ L LE  +    P  +  L  L  L L    +      +  LK N
Sbjct: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492

Query: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI-----ENFRELRILILDKN 382
           L+ L +  + +  L   ++ L  ++EL L  +    IS  +      + + L+IL +  N
Sbjct: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN 552

Query: 383 LLKNIPEKI---SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439
           + K IP+ +   S      C+     KL  L   + K+ NL +L +   ++ +I   +  
Sbjct: 553 VSK-IPQAVVDVSSHLQKMCIHNDGTKLVMLNN-LKKMTNLTELELVHCDLERIPHAVFS 610

Query: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497
           L ++  L+   N +  +   +  ++ +K+  ++L +N I Y P  +  L SL  LS    
Sbjct: 611 LLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLS---- 666

Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
                               S NK+ +   H      ++YLDL  N I+ IP  I  + S
Sbjct: 667 -------------------FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQS 707

Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
           L    + CNK E+ P EL   + L+ L + +N L  +S  I NL  +  L+   N F   
Sbjct: 708 LQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEIL 767

Query: 618 PIELCQLQSLEQLNI 632
           P EL   ++L++  +
Sbjct: 768 PPELGDCRALKRAGL 782



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 106/441 (24%), Positives = 186/441 (42%), Gaps = 98/441 (22%)

Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367
           L+L   ++S LP  + E+  L++L ++  K   +   I QL  ++EL L    +++ S  
Sbjct: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485

Query: 368 IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNR 427
           +   +E                       L+ LS+  + + ELP +++ L NL +L+   
Sbjct: 486 LSFLKE----------------------NLKVLSVKFDDMRELPPWMYGLRNLEELY--- 520

Query: 428 NNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALD 487
                +   +SH           +I  +V +E                       L  L 
Sbjct: 521 -----LVGSLSH-----------DISRNVTLE----------------------SLRDLK 542

Query: 488 SLYYLSVNGNYISEIP---VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQ 544
           SL  LS+  N +S+IP   VD+S   Q + +     KL++ + +   + NL  L+L    
Sbjct: 543 SLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLN-NLKKMTNLTELELVHCD 600

Query: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC--NLK 602
           +++IP ++ +++SL                       Q LDL EN L+ I   +   +L+
Sbjct: 601 LERIPHAVFSLLSL-----------------------QELDLKENNLKSIEEIVSFQHLR 637

Query: 603 GIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNA 662
            +  L    N   + P  + +L SLE+L+ S     K+  LP  L    +++ LD+S N 
Sbjct: 638 KLTVLKLWHNSITYIPEHIKKLTSLERLSFSH---NKIEVLPSHLFLCNKIRYLDLSYND 694

Query: 663 IREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSL 722
           IR IP  IG L++L       N++  LP  L     L+ L +  N+L+ L   I N+  L
Sbjct: 695 IRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 754

Query: 723 KEINFDDN--PLLRPPVEICK 741
             ++   N   +L P +  C+
Sbjct: 755 SYLDVKGNHFEILPPELGDCR 775



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 74/318 (23%), Positives = 154/318 (48%), Gaps = 8/318 (2%)

Query: 157 PKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRIL 216
           P  I ++  ++ L L +  +K    A S     L++LS++ + +  LP  +  L NL  L
Sbjct: 460 PATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEEL 519

Query: 217 ----NVSHNHISHIPKE-ISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271
               ++SH+   ++  E +  L +++ L   +N  +   + ++   +L+ + +  +  + 
Sbjct: 520 YLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKL 579

Query: 272 IP-DTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPK--EIRELKNL 328
           +  + L  +  L  L L +  L   P A+  L  L  LDL  N + S+ +    + L+ L
Sbjct: 580 VMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKL 639

Query: 329 ETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIP 388
             L + HN +T++   I +L  ++ L  + NK+EV+   +    ++R L L  N ++ IP
Sbjct: 640 TVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIP 699

Query: 389 EKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEF 448
            +I     L+  S++ NK+  LP  ++    L+ L + +N++  ++  I +L  +  L+ 
Sbjct: 700 PEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDV 759

Query: 449 SGNIITDVPIEIKNCQKI 466
            GN    +P E+ +C+ +
Sbjct: 760 KGNHFEILPPELGDCRAL 777



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 59/209 (28%), Positives = 102/209 (48%), Gaps = 27/209 (12%)

Query: 187 LLGLEILSLQENGLSSLPSEIQLLH--NLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
           LL L+ L L+EN L S+   +   H   L +L + HN I++IP+ I +L ++ +L F +N
Sbjct: 611 LLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHN 670

Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
            IE  PS L     +  L L  N +R IP  +  L++L+  +                  
Sbjct: 671 KIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS------------------ 712

Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI 364
                +T N + SLP E+   K L+TL +  N L+ L+ +I  LL +  L +  N  E++
Sbjct: 713 -----ITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEIL 767

Query: 365 SHKIENFRELRI--LILDKNLLKNIPEKI 391
             ++ + R L+   L+++  L + +P  +
Sbjct: 768 PPELGDCRALKRAGLVVEDALFETLPSDV 796



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 84/358 (23%), Positives = 155/358 (43%), Gaps = 38/358 (10%)

Query: 402 LSDNKLTELPKYIHKLNN-------LRKLHVNRNNMVKIT--------DCISHLNNICSL 446
           +S+NKL +L      LNN        +KL  N +N +++         D +  +  + SL
Sbjct: 395 VSENKLKQL-----NLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSL 449

Query: 447 EFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL-DSLYYLSVNGNYISEIPVD 505
           +        +P  I     + ++ L    +      L  L ++L  LSV  + + E+P  
Sbjct: 450 KLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPW 509

Query: 506 ISFSKQLLHL--------ELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
           +   + L  L        ++S N  L   E    L +LK L + K+ + KIP ++ + +S
Sbjct: 510 MYGLRNLEELYLVGSLSHDISRNVTL---ESLRDLKSLKILSI-KSNVSKIPQAVVD-VS 564

Query: 558 LHVLILCCNKFET---FPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQF 614
            H+  +C +   T       L  + NL  L+L    L++I   + +L  +Q+L+   N  
Sbjct: 565 SHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL 624

Query: 615 IHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELR 674
                E+   Q L +L + ++    +T +P  +  +T L+ L  S+N I  +P ++    
Sbjct: 625 KSIE-EIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCN 683

Query: 675 NLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPL 732
            +  L    N I ++PP +  L  LQ  +++ N + +LP  +Y    LK +    N L
Sbjct: 684 KIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741


>gi|197333692 leucine rich repeat containing 8 family, member B
           [Homo sapiens]
          Length = 803

 Score =  115 bits (287), Expect = 2e-25
 Identities = 113/396 (28%), Positives = 191/396 (48%), Gaps = 40/396 (10%)

Query: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQL-FFYNNYIENFPSDLECLGN 258
           L+ LP  +  L  + +L++       +P  +SQL N+++L  ++++ + + P+      N
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488

Query: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNLEY----NQLTTFP-KALCFLPKLISLDLTGN 313
           L+IL L   ++  IP  +  LK L+ L L       QL+T   +    L  L +L L  +
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548

Query: 314 LISSLPKEIREL-KNLETLLMDH--NKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN 370
           L S +P+ + +L  +L+ L +D+  +KL  L   + +++ +K L+L    LE I H I +
Sbjct: 549 L-SRIPQVVTDLLPSLQKLSLDNEGSKLVVLN-NLKKMVNLKSLELISCDLERIPHSIFS 606

Query: 371 FRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
              L  L L +N LK + E IS   +  L CL L  N +  +P  I  L+NL +L ++ N
Sbjct: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666

Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
           N                       I ++P+++  C K+  ++LSYN + + P  +  L +
Sbjct: 667 N-----------------------IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSN 703

Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
           L Y +V  N I  +P  +   K+L  L L +N L+  S H   L NL +L+L  N ++ +
Sbjct: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763

Query: 549 PASISNMISL--HVLILCCNKFETFPRELCTLENLQ 582
           P  +    SL  + LI+  N   T P  L   E LQ
Sbjct: 764 PPELEGCQSLKRNCLIVEENLLNTLP--LPVTERLQ 797



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 67/216 (31%), Positives = 111/216 (51%), Gaps = 8/216 (3%)

Query: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEIS--QLGNIRQLFFYNN 244
           ++ L+ L L    L  +P  I  L+NL  L++  N++  + + IS   L N+  L  ++N
Sbjct: 584 MVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHN 643

Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
            I   P+ +  L NLE LSL  N + ++P  L     L  L+L YN LT  P+ + +L  
Sbjct: 644 NIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSN 703

Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI 364
           L    +T N I  LP  + + K L+ LL+  N L  L+  + +L  +  L+L  N LE +
Sbjct: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763

Query: 365 SHKIENFRELR--ILILDKNLLKNIP----EKISCC 394
             ++E  + L+   LI+++NLL  +P    E++  C
Sbjct: 764 PPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTC 799



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 81/298 (27%), Positives = 134/298 (44%), Gaps = 32/298 (10%)

Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLD----KNQIKTFQGADSGDLLGLEIL-------- 193
           + L+   + + P+ +  +K +K LYL       Q+ T Q     DL  L  L        
Sbjct: 492 LRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSR 551

Query: 194 ----------SLQENGLSSLPSEIQLLHNLR------ILNVSHNHISHIPKEISQLGNIR 237
                     SLQ+  L +  S++ +L+NL+       L +    +  IP  I  L N+ 
Sbjct: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611

Query: 238 QLFFYNNYIENFPS--DLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTF 295
           +L    N ++        + L NL  L L  N + +IP  + +L  L  L+L++N +   
Sbjct: 612 ELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENL 671

Query: 296 PKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQ 355
           P  L    KL  LDL+ N ++ +P+EI+ L NL+   + +N +  L   +FQ  K++ L 
Sbjct: 672 PLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731

Query: 356 LADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLE--CLSLSDNKLTELP 411
           L  N L  +S  +     L  L L  N L+ +P ++  C  L+  CL + +N L  LP
Sbjct: 732 LGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 100/399 (25%), Positives = 179/399 (44%), Gaps = 75/399 (18%)

Query: 128 QVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGD- 186
           +VSE   KQ+ L               E+  + LK K VK    DK ++  F      D 
Sbjct: 390 EVSENKLKQINLN-------------NEWTVEKLKSKLVKNAQ-DKIELHLFMLNGLPDN 435

Query: 187 ---LLGLEILSLQENGLSSLPS---------EIQLLH---------------NLRILNVS 219
              L  +E+LSL+      LPS         E+++ H               NL+IL + 
Sbjct: 436 VFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLK 495

Query: 220 HNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-----NLEILSLGKNKLRHIP- 273
              +  IP+ +  L N+++L+     +    S ++  G     NL  L L K+ L  IP 
Sbjct: 496 FTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYL-KSSLSRIPQ 554

Query: 274 ---DTLPSLKTL----------------RVLNLEYNQLTT-----FPKALCFLPKLISLD 309
              D LPSL+ L                +++NL+  +L +      P ++  L  L  LD
Sbjct: 555 VVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELD 614

Query: 310 LTGNLISSLPKEI--RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367
           L  N + ++ + I  + L+NL  L + HN + ++  +I  L  +++L L  N +E +  +
Sbjct: 615 LRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQ 674

Query: 368 IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNR 427
           +    +L  L L  N L  IPE+I   + L+  ++++N +  LP  + +   L+ L + +
Sbjct: 675 LFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGK 734

Query: 428 NNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466
           N+++ ++  +  L+N+  LE  GN +  +P E++ CQ +
Sbjct: 735 NSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 103/376 (27%), Positives = 165/376 (43%), Gaps = 43/376 (11%)

Query: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373
           +++ LP  + EL  +E L ++      L   + QL+ +KEL++  + L V+ H    F E
Sbjct: 428 MLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSL-VVDHPALAFLE 486

Query: 374 --LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIH-----KLNNLRKLHVN 426
             L+IL L    +  IP  +     L+ L LS   L E    +       L NLR L++ 
Sbjct: 487 ENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYL- 545

Query: 427 RNNMVKI----TDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLG 482
           ++++ +I    TD +  L  + SL+  G+ +    + + N +K++ ++            
Sbjct: 546 KSSLSRIPQVVTDLLPSLQKL-SLDNEGSKL----VVLNNLKKMVNLK------------ 588

Query: 483 LCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDL 540
                SL  +S +   +  IP  I     L  L+L EN L    E   F  L NL  L L
Sbjct: 589 -----SLELISCD---LERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKL 640

Query: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600
             N I  IPA I  + +L  L L  N  E  P +L     L  LDLS N L  I  +I  
Sbjct: 641 WHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQY 700

Query: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660
           L  +Q    ++N     P  L Q + L+ L + +     L+   GELSN+T    L++  
Sbjct: 701 LSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLT---HLELIG 757

Query: 661 NAIREIPRNIGELRNL 676
           N +  +P  +   ++L
Sbjct: 758 NYLETLPPELEGCQSL 773



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 56/153 (36%), Positives = 78/153 (50%), Gaps = 4/153 (2%)

Query: 182 ADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFF 241
           A  G L  LE LSL  N + +LP ++ L   L  L++S+NH++ IP+EI  L N++    
Sbjct: 650 AQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAV 709

Query: 242 YNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL-- 299
            NN IE  P  L     L+ L LGKN L ++   +  L  L  L L  N L T P  L  
Sbjct: 710 TNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEG 769

Query: 300 CFLPKLISLDLTGNLISSLPKEIRELKNLETLL 332
           C   K   L +  NL+++LP  + E   L+T L
Sbjct: 770 CQSLKRNCLIVEENLLNTLPLPVTE--RLQTCL 800



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 97/431 (22%), Positives = 188/431 (43%), Gaps = 41/431 (9%)

Query: 355 QLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYI 414
           ++++NKL+ I+       E  +  L   L+KN  +KI     +         L  LP  +
Sbjct: 390 EVSENKLKQINLN----NEWTVEKLKSKLVKNAQDKIELHLFM---------LNGLPDNV 436

Query: 415 HKLNNLRKLHVNRNNMVKITDCISHLNNICSLE-FSGNIITDVPIEIKNCQKIIKIELSY 473
            +L  +  L +     VK+   +S L N+  L  +  +++ D P      + +  + L +
Sbjct: 437 FELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKF 496

Query: 474 NKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLI 533
            ++   P  +  L +L  L ++G  + E         QL  ++L         E F  L 
Sbjct: 497 TEMGKIPRWVFHLKNLKELYLSGCVLPE---------QLSTMQL---------EGFQDLK 538

Query: 534 NLKYLDLGKNQIKKIPASISNMI-SLHVLILCCNKFETFP-RELCTLENLQVLDLSENQL 591
           NL+ L L K+ + +IP  +++++ SL  L L     +      L  + NL+ L+L    L
Sbjct: 539 NLRTLYL-KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDL 597

Query: 592 QKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMT 651
           ++I   I +L  + +L+   N  +    E+   Q L+ L+  ++    +  +P ++  ++
Sbjct: 598 ERIPHSIFSLNNLHELDLRENN-LKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALS 656

Query: 652 QLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTA 711
            L++L + +N I  +P  +     L  L    N ++++P  +  L++LQ   ++ NN+  
Sbjct: 657 NLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEM 716

Query: 712 LPSAIYNIFSLKEINFDDNPL--LRPPV-EICKGKQLYTIARYLQRADERDE--KILEKI 766
           LP  ++    L+ +    N L  L P V E+     L  I  YL+      E  + L++ 
Sbjct: 717 LPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776

Query: 767 FKIVANNITET 777
             IV  N+  T
Sbjct: 777 CLIVEENLLNT 787


>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
           sapiens]
          Length = 803

 Score =  115 bits (287), Expect = 2e-25
 Identities = 113/396 (28%), Positives = 191/396 (48%), Gaps = 40/396 (10%)

Query: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQL-FFYNNYIENFPSDLECLGN 258
           L+ LP  +  L  + +L++       +P  +SQL N+++L  ++++ + + P+      N
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488

Query: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNLEY----NQLTTFP-KALCFLPKLISLDLTGN 313
           L+IL L   ++  IP  +  LK L+ L L       QL+T   +    L  L +L L  +
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548

Query: 314 LISSLPKEIREL-KNLETLLMDH--NKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN 370
           L S +P+ + +L  +L+ L +D+  +KL  L   + +++ +K L+L    LE I H I +
Sbjct: 549 L-SRIPQVVTDLLPSLQKLSLDNEGSKLVVLN-NLKKMVNLKSLELISCDLERIPHSIFS 606

Query: 371 FRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
              L  L L +N LK + E IS   +  L CL L  N +  +P  I  L+NL +L ++ N
Sbjct: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666

Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
           N                       I ++P+++  C K+  ++LSYN + + P  +  L +
Sbjct: 667 N-----------------------IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSN 703

Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
           L Y +V  N I  +P  +   K+L  L L +N L+  S H   L NL +L+L  N ++ +
Sbjct: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763

Query: 549 PASISNMISL--HVLILCCNKFETFPRELCTLENLQ 582
           P  +    SL  + LI+  N   T P  L   E LQ
Sbjct: 764 PPELEGCQSLKRNCLIVEENLLNTLP--LPVTERLQ 797



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 67/216 (31%), Positives = 111/216 (51%), Gaps = 8/216 (3%)

Query: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEIS--QLGNIRQLFFYNN 244
           ++ L+ L L    L  +P  I  L+NL  L++  N++  + + IS   L N+  L  ++N
Sbjct: 584 MVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHN 643

Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
            I   P+ +  L NLE LSL  N + ++P  L     L  L+L YN LT  P+ + +L  
Sbjct: 644 NIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSN 703

Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI 364
           L    +T N I  LP  + + K L+ LL+  N L  L+  + +L  +  L+L  N LE +
Sbjct: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763

Query: 365 SHKIENFRELR--ILILDKNLLKNIP----EKISCC 394
             ++E  + L+   LI+++NLL  +P    E++  C
Sbjct: 764 PPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTC 799



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 81/298 (27%), Positives = 134/298 (44%), Gaps = 32/298 (10%)

Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLD----KNQIKTFQGADSGDLLGLEIL-------- 193
           + L+   + + P+ +  +K +K LYL       Q+ T Q     DL  L  L        
Sbjct: 492 LRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSR 551

Query: 194 ----------SLQENGLSSLPSEIQLLHNLR------ILNVSHNHISHIPKEISQLGNIR 237
                     SLQ+  L +  S++ +L+NL+       L +    +  IP  I  L N+ 
Sbjct: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611

Query: 238 QLFFYNNYIENFPS--DLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTF 295
           +L    N ++        + L NL  L L  N + +IP  + +L  L  L+L++N +   
Sbjct: 612 ELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENL 671

Query: 296 PKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQ 355
           P  L    KL  LDL+ N ++ +P+EI+ L NL+   + +N +  L   +FQ  K++ L 
Sbjct: 672 PLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731

Query: 356 LADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLE--CLSLSDNKLTELP 411
           L  N L  +S  +     L  L L  N L+ +P ++  C  L+  CL + +N L  LP
Sbjct: 732 LGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 100/399 (25%), Positives = 179/399 (44%), Gaps = 75/399 (18%)

Query: 128 QVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGD- 186
           +VSE   KQ+ L               E+  + LK K VK    DK ++  F      D 
Sbjct: 390 EVSENKLKQINLN-------------NEWTVEKLKSKLVKNAQ-DKIELHLFMLNGLPDN 435

Query: 187 ---LLGLEILSLQENGLSSLPS---------EIQLLH---------------NLRILNVS 219
              L  +E+LSL+      LPS         E+++ H               NL+IL + 
Sbjct: 436 VFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLK 495

Query: 220 HNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-----NLEILSLGKNKLRHIP- 273
              +  IP+ +  L N+++L+     +    S ++  G     NL  L L K+ L  IP 
Sbjct: 496 FTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYL-KSSLSRIPQ 554

Query: 274 ---DTLPSLKTL----------------RVLNLEYNQLTT-----FPKALCFLPKLISLD 309
              D LPSL+ L                +++NL+  +L +      P ++  L  L  LD
Sbjct: 555 VVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELD 614

Query: 310 LTGNLISSLPKEI--RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367
           L  N + ++ + I  + L+NL  L + HN + ++  +I  L  +++L L  N +E +  +
Sbjct: 615 LRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQ 674

Query: 368 IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNR 427
           +    +L  L L  N L  IPE+I   + L+  ++++N +  LP  + +   L+ L + +
Sbjct: 675 LFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGK 734

Query: 428 NNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466
           N+++ ++  +  L+N+  LE  GN +  +P E++ CQ +
Sbjct: 735 NSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 103/376 (27%), Positives = 165/376 (43%), Gaps = 43/376 (11%)

Query: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373
           +++ LP  + EL  +E L ++      L   + QL+ +KEL++  + L V+ H    F E
Sbjct: 428 MLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSL-VVDHPALAFLE 486

Query: 374 --LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIH-----KLNNLRKLHVN 426
             L+IL L    +  IP  +     L+ L LS   L E    +       L NLR L++ 
Sbjct: 487 ENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYL- 545

Query: 427 RNNMVKI----TDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLG 482
           ++++ +I    TD +  L  + SL+  G+ +    + + N +K++ ++            
Sbjct: 546 KSSLSRIPQVVTDLLPSLQKL-SLDNEGSKL----VVLNNLKKMVNLK------------ 588

Query: 483 LCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDL 540
                SL  +S +   +  IP  I     L  L+L EN L    E   F  L NL  L L
Sbjct: 589 -----SLELISCD---LERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKL 640

Query: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600
             N I  IPA I  + +L  L L  N  E  P +L     L  LDLS N L  I  +I  
Sbjct: 641 WHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQY 700

Query: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660
           L  +Q    ++N     P  L Q + L+ L + +     L+   GELSN+T    L++  
Sbjct: 701 LSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLT---HLELIG 757

Query: 661 NAIREIPRNIGELRNL 676
           N +  +P  +   ++L
Sbjct: 758 NYLETLPPELEGCQSL 773



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 56/153 (36%), Positives = 78/153 (50%), Gaps = 4/153 (2%)

Query: 182 ADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFF 241
           A  G L  LE LSL  N + +LP ++ L   L  L++S+NH++ IP+EI  L N++    
Sbjct: 650 AQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAV 709

Query: 242 YNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL-- 299
            NN IE  P  L     L+ L LGKN L ++   +  L  L  L L  N L T P  L  
Sbjct: 710 TNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEG 769

Query: 300 CFLPKLISLDLTGNLISSLPKEIRELKNLETLL 332
           C   K   L +  NL+++LP  + E   L+T L
Sbjct: 770 CQSLKRNCLIVEENLLNTLPLPVTE--RLQTCL 800



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 97/431 (22%), Positives = 188/431 (43%), Gaps = 41/431 (9%)

Query: 355 QLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYI 414
           ++++NKL+ I+       E  +  L   L+KN  +KI     +         L  LP  +
Sbjct: 390 EVSENKLKQINLN----NEWTVEKLKSKLVKNAQDKIELHLFM---------LNGLPDNV 436

Query: 415 HKLNNLRKLHVNRNNMVKITDCISHLNNICSLE-FSGNIITDVPIEIKNCQKIIKIELSY 473
            +L  +  L +     VK+   +S L N+  L  +  +++ D P      + +  + L +
Sbjct: 437 FELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKF 496

Query: 474 NKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLI 533
            ++   P  +  L +L  L ++G  + E         QL  ++L         E F  L 
Sbjct: 497 TEMGKIPRWVFHLKNLKELYLSGCVLPE---------QLSTMQL---------EGFQDLK 538

Query: 534 NLKYLDLGKNQIKKIPASISNMI-SLHVLILCCNKFETFP-RELCTLENLQVLDLSENQL 591
           NL+ L L K+ + +IP  +++++ SL  L L     +      L  + NL+ L+L    L
Sbjct: 539 NLRTLYL-KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDL 597

Query: 592 QKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMT 651
           ++I   I +L  + +L+   N  +    E+   Q L+ L+  ++    +  +P ++  ++
Sbjct: 598 ERIPHSIFSLNNLHELDLRENN-LKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALS 656

Query: 652 QLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTA 711
            L++L + +N I  +P  +     L  L    N ++++P  +  L++LQ   ++ NN+  
Sbjct: 657 NLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEM 716

Query: 712 LPSAIYNIFSLKEINFDDNPL--LRPPV-EICKGKQLYTIARYLQRADERDE--KILEKI 766
           LP  ++    L+ +    N L  L P V E+     L  I  YL+      E  + L++ 
Sbjct: 717 LPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776

Query: 767 FKIVANNITET 777
             IV  N+  T
Sbjct: 777 CLIVEENLLNT 787


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  112 bits (279), Expect = 2e-24
 Identities = 112/395 (28%), Positives = 201/395 (50%), Gaps = 22/395 (5%)

Query: 154 QEFPKDILKIKYVKYLYLDKNQIKTF-QGADSGDLLGLEILSLQENGLSSLPSE-IQLLH 211
           Q  P  +  +++++ L L  N +    +GA +G L  L++L LQ N L  +P+E +Q L 
Sbjct: 80  QLLPNPLPSLRFLEELRLAGNALTYIPKGAFTG-LYSLKVLMLQNNQLRHVPTEALQNLR 138

Query: 212 NLRILNVSHNHISHIPKE-ISQLGNIRQLFFYNNYIENFP-SDLECLGNLEILSLGKNKL 269
           +L+ L +  NHIS++P    S L ++R L+  +N +   P      L  L+ ++L  NK+
Sbjct: 139 SLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKI 198

Query: 270 RHIPD-TLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTGNLISSLPKEIRELK 326
            HIPD    +L +L VL+L  N++ +  K  CF  L  L +LDL  N +   P  IR L 
Sbjct: 199 HHIPDYAFGNLSSLVVLHLHNNRIHSLGKK-CFDGLHSLETLDLNYNNLDEFPTAIRTLS 257

Query: 327 NLETLLMDHNKLTFLAVEIF-QLLKIKELQLADNKLEVISHK-IENFRELRILILD-KNL 383
           NL+ L    N +  +  + F     +  +   DN ++ +     ++  ELR L L+  + 
Sbjct: 258 NLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQ 317

Query: 384 LKNIPEKISCCAMLECLSLSDNKLTELPKYI-HKLNNLRKLHVNRNNMVKITDCISHLNN 442
           +   P+ ++  A LE L+L+  +++ LP+ + ++L NL+ L ++  N+++     S    
Sbjct: 318 ITEFPD-LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLS-YNLLEDLPSFSVCQK 375

Query: 443 ICSLEFSGNIITDVPIE-IKNCQKIIKIELSYNKI-MYFPLGLCALDSLYYLSVNGNYIS 500
           +  ++   N I ++ ++  +    +  + L++NKI +  P     L SL  L ++ N +S
Sbjct: 376 LQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435

Query: 501 EIPVDISFSKQLLHLELSEN---KLLIFSEHFCSL 532
             P  I+    L HL+L+ N   + LI SE+F  L
Sbjct: 436 SFP--ITGLHGLTHLKLTGNHALQSLISSENFPEL 468



 Score =  107 bits (266), Expect = 6e-23
 Identities = 121/415 (29%), Positives = 195/415 (46%), Gaps = 33/415 (7%)

Query: 308 LDLTGNLISSL-PKEIRELKNLETLLMDHNKLTFLAVEIFQ-LLKIKELQLADNKLE-VI 364
           LDL+ N IS L P  +  L+ LE L +  N LT++    F  L  +K L L +N+L  V 
Sbjct: 71  LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130

Query: 365 SHKIENFRELRILILDKNLLKNIPEKISCCAMLECLS---LSDNKLTELP-KYIHKLNNL 420
           +  ++N R L+ L LD N +  +P   SC + L  L    L DN LTE+P +    L+ L
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPP--SCFSGLHSLRHLWLDDNALTEIPVQAFRSLSAL 188

Query: 421 RKLHVNRNNMVKITD-CISHLNNICSLEFSGNIITDVPIEIKNC----QKIIKIELSYNK 475
           + + +  N +  I D    +L+++  L    N I  +    K C      +  ++L+YN 
Sbjct: 189 QAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLG---KKCFDGLHSLETLDLNYNN 245

Query: 476 IMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSK-QLLHLELSENKL-LIFSEHFCSLI 533
           +  FP  +  L +L  L  + N I  IP         L+ +   +N +  +    F  L 
Sbjct: 246 LDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLP 305

Query: 534 NLKYLDL-GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCT-LENLQVLDLSENQL 591
            L+ L L G +QI + P  ++   +L  L L   +  + P+ +C  L NLQVLDLS N L
Sbjct: 306 ELRTLTLNGASQITEFP-DLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 364

Query: 592 QKISS-DICNLKGIQKLNFSSNQFIHFPIELCQ-LQSLEQLNISQIKGRKLTRLPGELSN 649
           + + S  +C  + +QK++   N+     ++  Q L SL  LN++  K   +   P   S 
Sbjct: 365 EDLPSFSVC--QKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIH--PNAFST 420

Query: 650 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNL 704
           +  L +LD+S+N +   P  I  L  L  L    N   +   SL+S  +  +L +
Sbjct: 421 LPSLIKLDLSSNLLSSFP--ITGLHGLTHLKLTGN---HALQSLISSENFPELKV 470



 Score =  101 bits (252), Expect = 3e-21
 Identities = 126/402 (31%), Positives = 189/402 (47%), Gaps = 17/402 (4%)

Query: 223 ISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD-TLPSLKT 281
           +S +P  +S   +   L   NN  +  P+ L  L  LE L L  N L +IP      L +
Sbjct: 57  LSELPSNLSVFTSYLDLSM-NNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYS 115

Query: 282 LRVLNLEYNQLTTFP-KALCFLPKLISLDLTGNLISSLPKE-IRELKNLETLLMDHNKLT 339
           L+VL L+ NQL   P +AL  L  L SL L  N IS +P      L +L  L +D N LT
Sbjct: 116 LKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALT 175

Query: 340 FLAVEIFQLLK-IKELQLADNKLEVI-SHKIENFRELRILILDKNLLKNIPEK-ISCCAM 396
            + V+ F+ L  ++ + LA NK+  I  +   N   L +L L  N + ++ +K       
Sbjct: 176 EIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHS 235

Query: 397 LECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLN-NICSLEFSGNIITD 455
           LE L L+ N L E P  I  L+NL++L  + NN+  I +     N ++ ++ F  N I  
Sbjct: 236 LETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQF 295

Query: 456 V-PIEIKNCQKIIKIELS-YNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDI-SFSKQL 512
           V     ++  ++  + L+  ++I  FP  L    +L  L++ G  IS +P  + +    L
Sbjct: 296 VGRSAFQHLPELRTLTLNGASQITEFP-DLTGTANLESLTLTGAQISSLPQTVCNQLPNL 354

Query: 513 LHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPA-SISNMISLHVLILCCNKFETF 571
             L+LS N LL     F     L+ +DL  N+I +I   +   ++SL  L L  NK    
Sbjct: 355 QVLDLSYN-LLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII 413

Query: 572 -PRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSN 612
            P    TL +L  LDLS N L   S  I  L G+  L  + N
Sbjct: 414 HPNAFSTLPSLIKLDLSSNLLS--SFPITGLHGLTHLKLTGN 453



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 68/222 (30%), Positives = 108/222 (48%), Gaps = 9/222 (4%)

Query: 537 YLDLGKNQIKKI-PASISNMISLHVLILCCNKFETFPRELCT-LENLQVLDLSENQLQKI 594
           YLDL  N I ++ P  + ++  L  L L  N     P+   T L +L+VL L  NQL+ +
Sbjct: 70  YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129

Query: 595 SSD-ICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE-LSNMTQ 652
            ++ + NL+ +Q L   +N   + P        L  L    +    LT +P +   +++ 
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSC--FSGLHSLRHLWLDDNALTEIPVQAFRSLSA 187

Query: 653 LKELDISNNAIREIPRN-IGELRNLVSLHAYNNQISYLPPSLLS-LNDLQQLNLSGNNLT 710
           L+ + ++ N I  IP    G L +LV LH +NN+I  L       L+ L+ L+L+ NNL 
Sbjct: 188 LQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLD 247

Query: 711 ALPSAIYNIFSLKEINFDDNPLLRPPVEICKGK-QLYTIARY 751
             P+AI  + +LKE+ F  N +   P +   G   L TI  Y
Sbjct: 248 EFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFY 289



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 88/331 (26%), Positives = 147/331 (44%), Gaps = 48/331 (14%)

Query: 469 IELSYNKI-MYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLL--IF 525
           ++LS N I    P  L +L  L  L + GN ++ IP         L + + +N  L  + 
Sbjct: 71  LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130

Query: 526 SEHFCSLINLKYLDLGKNQIKKIPAS-ISNMISLHVLILCCNKFETFP-RELCTLENLQV 583
           +E   +L +L+ L L  N I  +P S  S + SL  L L  N     P +   +L  LQ 
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190

Query: 584 LDLSENQLQKISS-DICNLKGIQKLNFSSNQFIHFPIELC--QLQSLEQLNISQIKGRKL 640
           + L+ N++  I      NL  +  L+  +N+ IH   + C   L SLE L+++      L
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNR-IHSLGKKCFDGLHSLETLDLNY---NNL 246

Query: 641 TRLPGELSNMTQLKELDISNNAIREIPRN--IGELRNLVSLHAYNNQISY--------LP 690
              P  +  ++ LKEL   +N IR IP    +G   +L+++H Y+N I +        LP
Sbjct: 247 DEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGN-PSLITIHFYDNPIQFVGRSAFQHLP 305

Query: 691 ----------------PSLLSLNDLQQLNLSGNNLTALPSAIYN-IFSLKEINFDDNPLL 733
                           P L    +L+ L L+G  +++LP  + N + +L+ ++   N L 
Sbjct: 306 ELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLE 365

Query: 734 RPPVEICKGKQLYTIARYLQRADERDEKILE 764
             P         +++ + LQ+ D R  +I E
Sbjct: 366 DLP--------SFSVCQKLQKIDLRHNEIYE 388


>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
          Length = 347

 Score =  112 bits (279), Expect = 2e-24
 Identities = 63/204 (30%), Positives = 110/204 (53%), Gaps = 1/204 (0%)

Query: 400 LSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIE 459
           ++L+  K+T++P  + KL  L+ L +  N + K+   + +L  + +L    N++ +VP E
Sbjct: 19  ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78

Query: 460 IKNCQKIIKIELSYNKIMYFPLGLC-ALDSLYYLSVNGNYISEIPVDISFSKQLLHLELS 518
           +K    +  + LS N+I  F  G C  L +L  L++N N+++++P ++S  K L ++ ++
Sbjct: 79  MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138

Query: 519 ENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTL 578
            N+L       C L NL  L L  NQ+  IP  I  +  L  L+L  N     P ELC L
Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198

Query: 579 ENLQVLDLSENQLQKISSDICNLK 602
           + L++LD++ N +Q   S   +LK
Sbjct: 199 KKLRILDIAGNIIQIFPSGFQDLK 222



 Score =  110 bits (274), Expect = 7e-24
 Identities = 64/193 (33%), Positives = 107/193 (55%), Gaps = 4/193 (2%)

Query: 185 GDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
           G L GL+ L LQ N +  +  E+  L  L  LN+ +N +  +P+E+  L +++ L    N
Sbjct: 34  GKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGN 93

Query: 245 YIENF-PSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLP 303
            I  F P   + L NL +L+L  N L  +P  +  LK+L  +++ YNQL + P+ LCFL 
Sbjct: 94  RICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLE 153

Query: 304 KLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEV 363
            L+ L L  N +  +P+EI+ LK L+ LL+  N +  L  E+  L K++ L +A N +++
Sbjct: 154 NLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQI 213

Query: 364 ISHKIENFRELRI 376
                  F++L++
Sbjct: 214 FP---SGFQDLKL 223



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 67/254 (26%), Positives = 116/254 (45%), Gaps = 11/254 (4%)

Query: 534 NLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQK 593
           N K + L   ++ K+P+++  +  L  L+L  N       ELC L  L  L+L  N L++
Sbjct: 15  NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74

Query: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQL 653
           +  ++  L  ++ L+ S N+   F    C    L+ L +  +    LT+LP E+S +  L
Sbjct: 75  VPEEMKYLTSLKNLHLSGNRICRFAPGACD--GLQNLILLNLNNNHLTQLPQEVSRLKSL 132

Query: 654 KELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALP 713
             + I+ N +  IPR +  L NLV L    NQ+  +P  +  L  LQ+L L+ NN+  LP
Sbjct: 133 TYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLP 192

Query: 714 SAIYNIFSLKEINFDDNPL---------LRPPVEICKGKQLYTIARYLQRADERDEKILE 764
             + ++  L+ ++   N +         L+     C+G  L+     +    E    + E
Sbjct: 193 EELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENVWSLQE 252

Query: 765 KIFKIVANNITETN 778
              + V N + E N
Sbjct: 253 ITSRFVMNQLAENN 266



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 59/199 (29%), Positives = 111/199 (55%), Gaps = 1/199 (0%)

Query: 191 EILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP 250
           +I++L    ++ +PS +  L  L+ L + +N I  +  E+  L  +  L   NN +E  P
Sbjct: 17  KIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVP 76

Query: 251 SDLECLGNLEILSLGKNKL-RHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLD 309
            +++ L +L+ L L  N++ R  P     L+ L +LNL  N LT  P+ +  L  L  + 
Sbjct: 77  EEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMS 136

Query: 310 LTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIE 369
           +  N ++S+P+E+  L+NL  L +++N+L  +  EI  L K+++L LA N + V+  ++ 
Sbjct: 137 INYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELC 196

Query: 370 NFRELRILILDKNLLKNIP 388
           + ++LRIL +  N+++  P
Sbjct: 197 DLKKLRILDIAGNIIQIFP 215



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 67/238 (28%), Positives = 122/238 (51%), Gaps = 3/238 (1%)

Query: 212 NLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271
           N +I+ ++   ++ +P  + +L  ++ L   NN I     +L  L  L  L+LG N L  
Sbjct: 15  NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74

Query: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCF-LPKLISLDLTGNLISSLPKEIRELKNLET 330
           +P+ +  L +L+ L+L  N++  F    C  L  LI L+L  N ++ LP+E+  LK+L  
Sbjct: 75  VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134

Query: 331 LLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEK 390
           + +++N+L  +  E+  L  + ELQL  N+L  I  +I+  ++L+ L+L +N +  +PE+
Sbjct: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194

Query: 391 ISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCIS-HLNNICSLE 447
           +     L  L ++ N +   P     L  LR+ +   N +      IS    N+ SL+
Sbjct: 195 LCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVISTQQENVWSLQ 251



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 62/189 (32%), Positives = 97/189 (51%), Gaps = 1/189 (0%)

Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
           +  +G  +T +P  +     +  + L  N I      LC L  L  L++  N + E+P +
Sbjct: 19  ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78

Query: 506 ISFSKQLLHLELSENKLLIFSEHFCS-LINLKYLDLGKNQIKKIPASISNMISLHVLILC 564
           + +   L +L LS N++  F+   C  L NL  L+L  N + ++P  +S + SL  + + 
Sbjct: 79  MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138

Query: 565 CNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQL 624
            N+  + PRELC LENL  L L+ NQL  I  +I  LK +QKL  + N     P ELC L
Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198

Query: 625 QSLEQLNIS 633
           + L  L+I+
Sbjct: 199 KKLRILDIA 207



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 59/204 (28%), Positives = 106/204 (51%), Gaps = 1/204 (0%)

Query: 280 KTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLT 339
           K  +++ L   ++T  P AL  LP L +L L  NLI  +  E+  L  L TL + +N L 
Sbjct: 14  KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73

Query: 340 FLAVEIFQLLKIKELQLADNKL-EVISHKIENFRELRILILDKNLLKNIPEKISCCAMLE 398
            +  E+  L  +K L L+ N++        +  + L +L L+ N L  +P+++S    L 
Sbjct: 74  EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133

Query: 399 CLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPI 458
            +S++ N+L  +P+ +  L NL +L +N N ++ I + I  L  +  L  + N I  +P 
Sbjct: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193

Query: 459 EIKNCQKIIKIELSYNKIMYFPLG 482
           E+ + +K+  ++++ N I  FP G
Sbjct: 194 ELCDLKKLRILDIAGNIIQIFPSG 217



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 69/244 (28%), Positives = 114/244 (46%), Gaps = 34/244 (13%)

Query: 145 TVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLP 204
           T+NL    L+E P+++  +  +K L+L  N+I  F       L  L +L+L  N L+ LP
Sbjct: 64  TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123

Query: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264
            E+  L +L  +++++N ++ IP         R+L F  N +E              L L
Sbjct: 124 QEVSRLKSLTYMSINYNQLASIP---------RELCFLENLVE--------------LQL 160

Query: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRE 324
             N+L  IP+ +  LK L+ L L  N +   P+ LC L KL  LD+ GN+I   P   ++
Sbjct: 161 NYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQD 220

Query: 325 LKNLE------TLLMDHNKLTFLAVEIFQLLKIKEL----QLADNKLEVISHKIENFREL 374
           LK  E       L +    ++     ++ L +I       QLA+N    +   IE + ++
Sbjct: 221 LKLREFYCEGNPLFLQQPVISTQQENVWSLQEITSRFVMNQLAENN-PFLMDDIERYPQV 279

Query: 375 RILI 378
           R +I
Sbjct: 280 RSMI 283



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 47/162 (29%), Positives = 82/162 (50%), Gaps = 4/162 (2%)

Query: 579 ENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGR 638
           +N +++ L+  ++ K+ S +  L G++ L   +N       ELC L  L  LN+      
Sbjct: 14  KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLG---NN 70

Query: 639 KLTRLPGELSNMTQLKELDISNNAI-REIPRNIGELRNLVSLHAYNNQISYLPPSLLSLN 697
            L  +P E+  +T LK L +S N I R  P     L+NL+ L+  NN ++ LP  +  L 
Sbjct: 71  LLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK 130

Query: 698 DLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
            L  ++++ N L ++P  +  + +L E+  + N L+  P EI
Sbjct: 131 SLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEI 172



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 61/202 (30%), Positives = 94/202 (46%), Gaps = 1/202 (0%)

Query: 228 KEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNL 287
           K +S   N + +      +   PS L  L  L+ L L  N +  +   L +L  L  LNL
Sbjct: 8   KALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNL 67

Query: 288 EYNQLTTFPKALCFLPKLISLDLTGNLISSL-PKEIRELKNLETLLMDHNKLTFLAVEIF 346
             N L   P+ + +L  L +L L+GN I    P     L+NL  L +++N LT L  E+ 
Sbjct: 68  GNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVS 127

Query: 347 QLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNK 406
           +L  +  + +  N+L  I  ++     L  L L+ N L  IPE+I     L+ L L+ N 
Sbjct: 128 RLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNN 187

Query: 407 LTELPKYIHKLNNLRKLHVNRN 428
           +  LP+ +  L  LR L +  N
Sbjct: 188 IGVLPEELCDLKKLRILDIAGN 209



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 29/98 (29%), Positives = 46/98 (46%)

Query: 647 LSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSG 706
           LS     K + ++   + ++P  +G+L  L +L   NN I  + P L +L  L  LNL  
Sbjct: 10  LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69

Query: 707 NNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQ 744
           N L  +P  +  + SLK ++   N + R     C G Q
Sbjct: 70  NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQ 107


>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
           containing 3 [Homo sapiens]
          Length = 712

 Score =  108 bits (270), Expect = 2e-23
 Identities = 71/209 (33%), Positives = 104/209 (49%), Gaps = 8/209 (3%)

Query: 538 LDLGKNQIKKIPASISN--MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKIS 595
           L L   ++++ P   +N  +       L  N+    P E C   +L+ L+L +N ++ I 
Sbjct: 62  LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121

Query: 596 SDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKE 655
             I NL+ +  LN S NQ    P+ LC L     L +      KL  LP E+ ++  L E
Sbjct: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLP----LKVLIASNNKLVSLPEEIGHLRHLME 177

Query: 656 LDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSA 715
           LD+S N I+ IP  IG L  L  L+   N + +LP  L  L  L +L+ S N +T +P  
Sbjct: 178 LDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLDFSCNKITTIPVC 236

Query: 716 IYNIFSLKEINFDDNPLLRPPVEIC-KGK 743
             N+  L+ I  D+NPL  PP +IC KGK
Sbjct: 237 YRNLRHLQTITLDNNPLQSPPAQICIKGK 265



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 70/228 (30%), Positives = 114/228 (50%), Gaps = 9/228 (3%)

Query: 469 IELSYNKIMYFPLGLCALD--SLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFS 526
           + LS  K+  FP G    D        ++ N +SEIP++      L +L L +N +    
Sbjct: 62  LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121

Query: 527 EHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDL 586
           E   +L  L +L++ +NQ+  +P  + N+  L VLI   NK  + P E+  L +L  LD+
Sbjct: 122 EAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDV 180

Query: 587 SENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE 646
           S N++Q I S I NL+ ++ LN   N  +H P EL +L  L +L+ S     K+T +P  
Sbjct: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLDFS---CNKITTIPVC 236

Query: 647 LSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY-NNQISYLPPSL 693
             N+  L+ + + NN ++  P  I  ++  V +  Y N Q   + P L
Sbjct: 237 YRNLRHLQTITLDNNPLQSPPAQIC-IKGKVHIFKYLNIQACKIAPDL 283



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 61/217 (28%), Positives = 104/217 (47%), Gaps = 4/217 (1%)

Query: 270 RHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTGNLISSLPKEIRELKN 327
           R +   L       VL+L   +L  FP+      L      DL+ N +S +P E     +
Sbjct: 47  RSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVS 106

Query: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNI 387
           LE L +  N + ++   I  L  +  L ++ N+L  +   + N   L++LI   N L ++
Sbjct: 107 LENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSL 165

Query: 388 PEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLE 447
           PE+I     L  L +S N++  +P  I  L  LR L+V RN++V + + ++ L  +  L+
Sbjct: 166 PEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLD 224

Query: 448 FSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLC 484
           FS N IT +P+  +N + +  I L  N +   P  +C
Sbjct: 225 FSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQIC 261



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 27/216 (12%)

Query: 215 ILNVSHNHISHIPKEISQ--LGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHI 272
           +L++S   +   P+  +   L +  +     N +   P +     +LE L+L +N +R+I
Sbjct: 61  VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120

Query: 273 PDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLL 332
           P+ + +L+ L  LN+  NQL+T P  LC LP                        L+ L+
Sbjct: 121 PEAILNLQALTFLNISRNQLSTLPVHLCNLP------------------------LKVLI 156

Query: 333 MDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKIS 392
             +NKL  L  EI  L  + EL ++ N+++ I  +I N   LR L + +N L ++PE+++
Sbjct: 157 ASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELA 216

Query: 393 CCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
              ++  L  S NK+T +P     L +L+ + ++ N
Sbjct: 217 ELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNN 251



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 67/257 (26%), Positives = 116/257 (45%), Gaps = 30/257 (11%)

Query: 385 KNIPEKISCCAMLECLSLSDNKLTELPKYI--HKLNNLRKLHVNRNNMVKITDCISHLNN 442
           +++   +   A+   LSLS  KL E P+    H L +  +  ++RN +            
Sbjct: 47  RSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRL------------ 94

Query: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502
                      +++PIE  +   +  + L  N I Y P  +  L +L +L+++ N +S +
Sbjct: 95  -----------SEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTL 143

Query: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562
           PV +  +  L  L  S NKL+   E    L +L  LD+  N+I+ IP+ I N+ +L  L 
Sbjct: 144 PVHLC-NLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLN 202

Query: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622
           +  N     P EL  L  ++ LD S N++  I     NL+ +Q +   +N     P ++C
Sbjct: 203 VRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQIC 261

Query: 623 ---QLQSLEQLNISQIK 636
              ++   + LNI   K
Sbjct: 262 IKGKVHIFKYLNIQACK 278



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 64/221 (28%), Positives = 104/221 (47%), Gaps = 34/221 (15%)

Query: 169 LYLDKNQIKTF-QGADSGDLLGLEILSLQENGLSSLPSE--------------------- 206
           L L   +++ F +GA + DL       L  N LS +P E                     
Sbjct: 62  LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121

Query: 207 --IQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264
             I  L  L  LN+S N +S +P  +  L  ++ L   NN + + P ++  L +L  L +
Sbjct: 122 EAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDV 180

Query: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRE 324
             N+++ IP  + +L+ LR LN+  N L   P+ L  LP LI LD + N I+++P   R 
Sbjct: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELP-LIRLDFSCNKITTIPVCYRN 239

Query: 325 LKNLETLLMDHNKLTFL--------AVEIFQLLKIKELQLA 357
           L++L+T+ +D+N L            V IF+ L I+  ++A
Sbjct: 240 LRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIA 280



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 53/192 (27%), Positives = 91/192 (47%), Gaps = 7/192 (3%)

Query: 118 SHETVGEVSPQVSEENQKQLGLGADNFT----VNLEAKGLQEFPKDILKIKYVKYLYLDK 173
           +H+        +S     ++ + A +F     +NL    ++  P+ IL ++ + +L + +
Sbjct: 78  NHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISR 137

Query: 174 NQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQL 233
           NQ+ T         L L++L    N L SLP EI  L +L  L+VS N I  IP +I  L
Sbjct: 138 NQLSTLPVHLCN--LPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNL 195

Query: 234 GNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLT 293
             +R L    N++ + P +L  L  +  L    NK+  IP    +L+ L+ + L+ N L 
Sbjct: 196 EALRDLNVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQ 254

Query: 294 TFPKALCFLPKL 305
           + P  +C   K+
Sbjct: 255 SPPAQICIKGKV 266



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 39/118 (33%), Positives = 60/118 (50%), Gaps = 3/118 (2%)

Query: 624 LQSLEQLNISQIKGRKLTRLPGELSN--MTQLKELDISNNAIREIPRNIGELRNLVSLHA 681
           L+      +  + GRKL   P   +N  +T     D+S N + EIP       +L +L+ 
Sbjct: 53  LEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNL 112

Query: 682 YNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
           Y N I Y+P ++L+L  L  LN+S N L+ LP  + N+  LK +   +N L+  P EI
Sbjct: 113 YQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEI 169


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  107 bits (267), Expect = 5e-23
 Identities = 128/465 (27%), Positives = 209/465 (44%), Gaps = 67/465 (14%)

Query: 255 CLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPK-ALCFLPKLISLDLTGN 313
           C G+  +   GK  L  +P+ L +    + L++  N +T  P+ A    P L  L L GN
Sbjct: 35  CDGDRRVDCSGKG-LTAVPEGLSAFT--QALDISMNNITQLPEDAFKNFPFLEELQLAGN 91

Query: 314 LISSL-PKEIRELKNLETLLMDHNKLTFLAVEIFQ-LLKIKELQLADNKL-EVISHKIEN 370
            +S + PK +  LK L+ L + +N+L  +  E  + L  ++ L+L  N +  V     E 
Sbjct: 92  DLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEG 151

Query: 371 FRELRILILDKNLLKNIP-EKISCCAMLECLSLSDNKLTELPKYIH-KLNNLRKLHVNRN 428
             +LR L LD N L  +P   +S    L+ L+L+ NK++ +P +    L++L  LH++ N
Sbjct: 152 LVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN 211

Query: 429 NMVKITD-CISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALD 487
            +  ++  C   L+N+ +L+                       L+YN +  FP  + AL 
Sbjct: 212 KIRSLSQHCFDGLDNLETLD-----------------------LNYNNLGEFPQAIKALP 248

Query: 488 SLYYLSVNGNYISEIPVDISFSKQLLH-LELSENKL-LIFSEHFCSLINLKYLDL-GKNQ 544
           SL  L  + N IS IP        LL  + L +N L  + +  F +L +L  L + G + 
Sbjct: 249 SLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASM 308

Query: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLEN-LQVLDLSENQLQKISSDICNLKG 603
           +++ P +++  + L  L L   K  + P  LC  +  L+ LDLS N ++    D+ +  G
Sbjct: 309 VQQFP-NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIR----DLPSFNG 363

Query: 604 IQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAI 663
              L               +  SL++  I QIK        G    +  L+ LD+S N I
Sbjct: 364 CHAL---------------EEISLQRNQIYQIK-------EGTFQGLISLRILDLSRNLI 401

Query: 664 REI-PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGN 707
            EI  R    L  + +L    N+++  P     LN L QL L GN
Sbjct: 402 HEIHSRAFATLGPITNLDVSFNELTSFPTE--GLNGLNQLKLVGN 444



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 101/397 (25%), Positives = 173/397 (43%), Gaps = 41/397 (10%)

Query: 138 GLGADNFTVNLEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQ 196
           GL A    +++    + + P+D  K   +++ L L  N +          L  L++L+LQ
Sbjct: 54  GLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQ 113

Query: 197 ENGLSSLPSE-IQLLHNLRILNVSHNHISHIPKEISQ-LGNIRQLFFYNNYIENFP-SDL 253
            N L ++PSE I+ L  L+ L +  NHI+ +P++  + L  +R L+  +N +   P   L
Sbjct: 114 NNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPL 173

Query: 254 ECLGNLEILSLGKNKLRHIPD-------------------------TLPSLKTLRVLNLE 288
             L  L+ L+L  NK+  IPD                             L  L  L+L 
Sbjct: 174 SNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLN 233

Query: 289 YNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKN-LETLLMDHNKLTFLAVEIF- 346
           YN L  FP+A+  LP L  L    N IS +P    +    L T+ +  N L+F+    F 
Sbjct: 234 YNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFH 293

Query: 347 QLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC---AMLECLSLS 403
            L  +  L +    +      +     L  L L    + +IP  +  C    ML  L LS
Sbjct: 294 NLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNL--CQEQKMLRTLDLS 351

Query: 404 DNKLTELPKYIHKLNNLRKLHVNRNNMVKITD-CISHLNNICSLEFSGNIITDVPIE-IK 461
            N + +LP + +  + L ++ + RN + +I +     L ++  L+ S N+I ++      
Sbjct: 352 YNNIRDLPSF-NGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFA 410

Query: 462 NCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNY 498
               I  +++S+N++  FP     L+ L  L + GN+
Sbjct: 411 TLGPITNLDVSFNELTSFPTE--GLNGLNQLKLVGNF 445



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 72/216 (33%), Positives = 102/216 (47%), Gaps = 21/216 (9%)

Query: 538 LDLGKNQIKKIPA-SISNMISLHVLILCCNKFETF-PRELCTLENLQVLDLSENQLQKIS 595
           LD+  N I ++P  +  N   L  L L  N      P+ L  L+ L+VL L  NQL+ + 
Sbjct: 62  LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121

Query: 596 SD-ICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE-LSNMTQL 653
           S+ I  L  +Q L   +N     P +    + L QL    +    LT +P   LSN+  L
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPED--SFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179

Query: 654 KELDISNNAIREIPR-NIGELRNLVSLHAYNNQISYLPPSLLS-LNDLQQLNLSGNNLTA 711
           + L ++ N I  IP      L +LV LH +NN+I  L       L++L+ L+L+ NNL  
Sbjct: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGE 239

Query: 712 LPSAIYNIFSLKEIN-------------FDDNPLLR 734
            P AI  + SLKE+              FD NPLLR
Sbjct: 240 FPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLR 275



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 72/282 (25%), Positives = 132/282 (46%), Gaps = 18/282 (6%)

Query: 445 SLEFSGNIITDVPIE-IKNCQKIIKIELSYNKIMYF-PLGLCALDSLYYLSVNGNYISEI 502
           +L+ S N IT +P +  KN   + +++L+ N + +  P  L  L  L  L++  N +  +
Sbjct: 61  ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV 120

Query: 503 PVD-ISFSKQLLHLELSENKLLIFSEH-FCSLINLKYLDLGKNQIKKIPAS-ISNMISLH 559
           P + I     L  L L  N +    E  F  L+ L++L L  N + ++P   +SN+ +L 
Sbjct: 121 PSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQ 180

Query: 560 VLILCCNKFETFPRELCT-LENLQVLDLSENQLQKISSDICN-LKGIQKLNFSSNQFIHF 617
            L L  NK  + P    T L +L VL L  N+++ +S    + L  ++ L+ + N    F
Sbjct: 181 ALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF 240

Query: 618 PIELCQLQSLEQLNISQIKGRKLTRLP-GELSNMTQLKELDISNNAIREIPR----NIGE 672
           P  +  L SL++L         ++ +P G       L+ + + +N +  +      N+ +
Sbjct: 241 PQAIKALPSLKELGFHS---NSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSD 297

Query: 673 LRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPS 714
           L +LV   A   Q     P+L     L+ L L+G  ++++P+
Sbjct: 298 LHSLVIRGASMVQQF---PNLTGTVHLESLTLTGTKISSIPN 336


>gi|4507531 toll-like receptor 3 [Homo sapiens]
          Length = 904

 Score =  107 bits (266), Expect = 6e-23
 Identities = 157/620 (25%), Positives = 270/620 (43%), Gaps = 62/620 (10%)

Query: 215 ILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS-DLECLGNLEILSLGKNKLRHI- 272
           + + SH  ++ +P ++    NI  L   +N +   P+ +      L  L +G N +  + 
Sbjct: 34  VADCSHLKLTQVPDDLPT--NITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLE 91

Query: 273 PDTLPSLKTLRVLNLEYNQLTTFP-KALCFLPKLISLDLTGNLISSLPKE-IRELKNLET 330
           P+    L  L+VLNL++N+L+    K   F   L  L L  N I  +      + KNL T
Sbjct: 92  PELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLIT 151

Query: 331 LLMDHNKL--TFLAVEIFQLLKIKELQLADNKLEVI-SHKIENFRE--LRILILDKNLLK 385
           L + HN L  T L  ++ QL  ++EL L++NK++ + S +++ F    L+ L L  N +K
Sbjct: 152 LDLSHNGLSSTKLGTQV-QLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIK 210

Query: 386 NI-PEKISCCAMLECLSLSDNKLTELPKYIHKL------NNLRKLHVNRNNMVKITDCIS 438
              P        L  L L++ +L   P    KL       ++R L ++ N+ +  T   +
Sbjct: 211 EFSPGCFHAIGRLFGLFLNNVQLG--PSLTEKLCLELANTSIRNLSLS-NSQLSTTSNTT 267

Query: 439 HLN----NICSLEFSGNIITDVPIE-IKNCQKIIKIELSYNKIMY-FPLGLCALDSLYYL 492
            L     N+  L+ S N +  V  +      ++    L YN I + F   L  L ++ YL
Sbjct: 268 FLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYL 327

Query: 493 SVNGNY------ISEIPVDISFSKQLL----HLELSENKLL-IFSEHFCSLINLKYLDLG 541
           ++  ++      ++ +P    FS Q L    HL + +N +  I S  F  LINLKYL L 
Sbjct: 328 NLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLS 387

Query: 542 KNQIKKIPASISNMISL-----HVLILCCNKFETFPRELCT-LENLQVLDLSENQL--QK 593
            +       +    +SL     H+L L  NK      +  + L +L+VLDL  N++  + 
Sbjct: 388 NSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQEL 447

Query: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQL-QSLEQLNISQIKGRKLTRLPGELSNMTQ 652
              +   L+ I ++  S N+++        L  SL++L + ++  + +   P     +  
Sbjct: 448 TGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRN 507

Query: 653 LKELDISNNAIREIPRNIGE-LRNLVSLHAYNNQISYLPPS---------LLSLNDLQQL 702
           L  LD+SNN I  I  ++ E L  L  L   +N ++ L            L  L+ L  L
Sbjct: 508 LTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHIL 567

Query: 703 NLSGNNLTALPSAIY-NIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEK 761
           NL  N    +P  ++ ++F LK I+   N L   P  +   +      + L         
Sbjct: 568 NLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQ---VSLKSLNLQKNLITS 624

Query: 762 ILEKIFKIVANNITETNFEF 781
           + +K+F     N+TE +  F
Sbjct: 625 VEKKVFGPAFRNLTELDMRF 644



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 134/541 (24%), Positives = 220/541 (40%), Gaps = 117/541 (21%)

Query: 117 LSHETVG--EVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKN 174
           LSH  +   ++  QV  EN ++L L       N + + L+    DI     +K L L  N
Sbjct: 154 LSHNGLSSTKLGTQVQLENLQELLLS------NNKIQALKSEELDIFANSSLKKLELSSN 207

Query: 175 QIKTFQGA---DSGDLLGLEILSLQENGLSSLPSEIQLLH-NLRILNVSHNHISHIPKEI 230
           QIK F        G L GL + ++Q     +    ++L + ++R L++S++ +S      
Sbjct: 208 QIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLS-TTSNT 266

Query: 231 SQLG----NIRQL-FFYNNYIENFPSDLECLGNLEILSLGKNKLRHI-PDTLPSLKTLRV 284
           + LG    N+  L   YNN           L  LE   L  N ++H+   +L  L  +R 
Sbjct: 267 TFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRY 326

Query: 285 LNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPK----EIRELKNLETLLMDHNKLTF 340
           LNL+ +          F  + ISL       +SLPK      + LK LE L M+ N +  
Sbjct: 327 LNLKRS----------FTKQSISL-------ASLPKIDDFSFQWLKCLEHLNMEDNDIPG 369

Query: 341 LAVEIFQ-LLKIKELQLADNKLEVISHKIENF-----RELRILILDKNLLKNIP-EKISC 393
           +   +F  L+ +K L L+++   + +   E F       L IL L KN +  I  +  S 
Sbjct: 370 IKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSW 429

Query: 394 CAMLECLSLSDNKLTE-------------------LPKYIHKLNN-------LRKLHVNR 427
              LE L L  N++ +                     KY+    N       L++L + R
Sbjct: 430 LGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRR 489

Query: 428 ---NNMVKITDCISHLNNICSLEFSGNIITDVPIE-IKNCQKIIKIELSYNKI------- 476
               N+         L N+  L+ S N I ++  + ++  +K+  ++L +N +       
Sbjct: 490 VALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHA 549

Query: 477 -----MYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCS 531
                +YF  GL     L+ L++  N   EIPV++                      F  
Sbjct: 550 NPGGPIYFLKGL---SHLHILNLESNGFDEIPVEV----------------------FKD 584

Query: 532 LINLKYLDLGKNQIKKIPASI-SNMISLHVLILCCNKFETFPRELC--TLENLQVLDLSE 588
           L  LK +DLG N +  +PAS+ +N +SL  L L  N   +  +++      NL  LD+  
Sbjct: 585 LFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRF 644

Query: 589 N 589
           N
Sbjct: 645 N 645


>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
          Length = 335

 Score =  106 bits (264), Expect = 1e-22
 Identities = 76/265 (28%), Positives = 135/265 (50%), Gaps = 9/265 (3%)

Query: 350 KIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409
           +IK+L     + +   HK+    E R+       L  + EK++       L +   +   
Sbjct: 21  RIKKLNEDLKREKEFQHKLVRIWEERVS------LTKLREKVTREDGRVILKIEKEEWKT 74

Query: 410 LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469
           LP  + KLN L++  ++R  ++KI + I    N+  L+ S N I+++P  I    ++ ++
Sbjct: 75  LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134

Query: 470 ELSYNKIMYFP--LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE 527
            LSYNKI   P  L  CA      L+VN + I ++P ++S   +L HL+LS N       
Sbjct: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRD-ICDLPQELSNLLKLTHLDLSMNDFTTIPL 193

Query: 528 HFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLS 587
              ++  L++LD+G N+++++P +I  M +LH L L  N+    P+ +  ++NL  L LS
Sbjct: 194 AVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLS 253

Query: 588 ENQLQKISSDICNLKGIQKLNFSSN 612
            N+LQ I   +  +  ++ +NF  N
Sbjct: 254 NNKLQDIPVCMEEMANLRFVNFRDN 278



 Score =  103 bits (258), Expect = 5e-22
 Identities = 75/246 (30%), Positives = 116/246 (47%), Gaps = 25/246 (10%)

Query: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIK 546
           D    L +       +P  +    QL   +L    LL   E      NL  LDL +N I 
Sbjct: 60  DGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTIS 119

Query: 547 KIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606
           +IP  I  +  L  LIL  NK +T P+EL    +L+ L+L+ N+      DIC+L     
Sbjct: 120 EIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNR------DICDL----- 168

Query: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666
                      P EL  L  L  L++S       T +P  + NM  L+ LD+ +N + ++
Sbjct: 169 -----------PQELSNLLKLTHLDLSM---NDFTTIPLAVLNMPALEWLDMGSNKLEQL 214

Query: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEIN 726
           P  I  ++NL +L    N+I+ LP ++ ++ +L  L LS N L  +P  +  + +L+ +N
Sbjct: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVN 274

Query: 727 FDDNPL 732
           F DNPL
Sbjct: 275 FRDNPL 280



 Score =  101 bits (252), Expect = 3e-21
 Identities = 76/239 (31%), Positives = 115/239 (48%), Gaps = 10/239 (4%)

Query: 148 LEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEI 207
           L  K  +E  + ILKI+  ++  L  + +K  Q         L+   L   GL  +P  I
Sbjct: 52  LREKVTREDGRVILKIEKEEWKTLPSSLLKLNQ---------LQEWQLHRTGLLKIPEFI 102

Query: 208 QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKN 267
               NL +L++S N IS IP  I  L  +++L    N I+  P +L    +LE L L  N
Sbjct: 103 GRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVN 162

Query: 268 K-LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326
           + +  +P  L +L  L  L+L  N  TT P A+  +P L  LD+  N +  LP  I  ++
Sbjct: 163 RDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQ 222

Query: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLK 385
           NL TL +  N++T L   I  +  +  L L++NKL+ I   +E    LR +    N LK
Sbjct: 223 NLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 63/220 (28%), Positives = 108/220 (49%), Gaps = 2/220 (0%)

Query: 215 ILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274
           IL +       +P  + +L  +++   +   +   P  +    NL +L L +N +  IP 
Sbjct: 64  ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123

Query: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL-ISSLPKEIRELKNLETLLM 333
            +  L  L+ L L YN++ T PK L     L  L+L  N  I  LP+E+  L  L  L +
Sbjct: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183

Query: 334 DHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISC 393
             N  T + + +  +  ++ L +  NKLE +   IE  + L  L L +N +  +P+ IS 
Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243

Query: 394 CAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKI 433
              L  L LS+NKL ++P  + ++ NLR ++  R+N +K+
Sbjct: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNF-RDNPLKL 282



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 74/260 (28%), Positives = 128/260 (49%), Gaps = 5/260 (1%)

Query: 376 ILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITD 435
           IL ++K   K +P  +     L+   L    L ++P++I +  NL  L ++RN + +I  
Sbjct: 64  ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123

Query: 436 CISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNK-IMYFPLGLCALDSLYYLSV 494
            I  L  +  L  S N I  VP E+ NC  + K+EL+ N+ I   P  L  L  L +L +
Sbjct: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183

Query: 495 NGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN 554
           + N  + IP+ +     L  L++  NKL    +    + NL  L L +N+I  +P +ISN
Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243

Query: 555 MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI---QKLNFSS 611
           M +L  L+L  NK +  P  +  + NL+ ++  +N L K+   +   +G    ++     
Sbjct: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL-KLKVSLPPSEGTDEEEERELFG 302

Query: 612 NQFIHFPIELCQLQSLEQLN 631
            QF+H  I+  + ++  Q+N
Sbjct: 303 LQFMHTYIQESRRRADHQVN 322



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 63/216 (29%), Positives = 104/216 (48%), Gaps = 6/216 (2%)

Query: 247 ENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLI 306
           +  PS L  L  L+   L +  L  IP+ +   + L VL+L  N ++  P  +  L +L 
Sbjct: 73  KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132

Query: 307 SLDLTGNLISSLPKEIRELKNLETLLMDHNK-LTFLAVEIFQLLKIKELQLADNKLEVIS 365
            L L+ N I ++PKE+    +LE L +  N+ +  L  E+  LLK+  L L+ N    I 
Sbjct: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192

Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425
             + N   L  L +  N L+ +P+ I     L  L L  N++T LP+ I  + NL  L +
Sbjct: 193 LAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVL 252

Query: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIK 461
           + N +  I  C+  + N+  + F  N     P+++K
Sbjct: 253 SNNKLQDIPVCMEEMANLRFVNFRDN-----PLKLK 283



 Score = 31.6 bits (70), Expect = 3.3
 Identities = 47/188 (25%), Positives = 75/188 (39%), Gaps = 19/188 (10%)

Query: 639 KLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLND 698
           KL R+  E  ++T+L+E         ++ R  G     V L     +   LP SLL LN 
Sbjct: 38  KLVRIWEERVSLTKLRE---------KVTREDGR----VILKIEKEEWKTLPSSLLKLNQ 84

Query: 699 LQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADER 758
           LQ+  L    L  +P  I    +L  ++   N +   P  I    +L  +     +    
Sbjct: 85  LQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTV 144

Query: 759 DEKI-----LEKIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTVSLSERAHQALVI 813
            +++     LEK+   V  +I +   E L   L L + +  M   +T+ L+     AL  
Sbjct: 145 PKELSNCASLEKLELAVNRDICDLPQE-LSNLLKLTHLDLSMNDFTTIPLAVLNMPALEW 203

Query: 814 WKTQSNKL 821
               SNKL
Sbjct: 204 LDMGSNKL 211


>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
           sapiens]
          Length = 810

 Score =  106 bits (264), Expect = 1e-22
 Identities = 96/372 (25%), Positives = 170/372 (45%), Gaps = 36/372 (9%)

Query: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK-N 327
           L  IPDT+  L  L VL LE     T P ++  L  L  L L           +  L+ N
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494

Query: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQL-----ADNKLEVISHKIENFRELRILILDKN 382
           L  L +    +  + + I+ L  ++EL L     A+N   ++   +   + L++L L  N
Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554

Query: 383 LLKNIPEKISCCAM-LECLSLSDN--KLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439
           L K +P+ ++   + L+ LS+++   KL  L   + K+ NL +L + R ++ +I   I  
Sbjct: 555 LSK-LPQVVTDVGVHLQKLSINNEGTKLIVLNS-LKKMANLTELELIRCDLERIPHSIFS 612

Query: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497
           L+N+  ++   N +  +   I  ++  ++  ++L YN I Y P+ +  L +L  L +N N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672

Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
            I +IP  + + ++L                       +YLDL  N +  +PA I  + +
Sbjct: 673 KIEKIPTQLFYCRKL-----------------------RYLDLSHNNLTFLPADIGLLQN 709

Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
           L  L +  N+ ET P EL     L+ L L  N LQ + S +  L  + ++    N+    
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769

Query: 618 PIELCQLQSLEQ 629
           P+EL +   L++
Sbjct: 770 PVELGECPLLKR 781



 Score =  103 bits (257), Expect = 7e-22
 Identities = 129/511 (25%), Positives = 212/511 (41%), Gaps = 38/511 (7%)

Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
           Y+ N   D++C  ++E L+      R      P     ++L   Y  L  F   +C    
Sbjct: 285 YVHNIKFDVDCTVDIESLT----GYRTYRCAHPLATLFKILASFYISLVIFYGLICMYT- 339

Query: 305 LISLDLTGNLISSLPK----EIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360
                L   L  SL K     IRE  +   +    N   F+   I Q   +   + A   
Sbjct: 340 -----LWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFL 394

Query: 361 LEVISHKIENFRELRILILDK---NLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKL 417
            EV  +K+          LDK    L KN  +K+     +         L+ +P  +  L
Sbjct: 395 SEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFM---------LSGIPDTVFDL 445

Query: 418 NNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT-DVPIEIKNCQKIIKIELSYNKI 476
             L  L +     V I   I+ L  +  L         + P      + +  + + +  I
Sbjct: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505

Query: 477 MYFPLGLCALDSLYYLSVNGNYISE----IPVD-ISFSKQLLHLELSENKLLIFSEHFCS 531
              PL + +L +L  L + GN  +E    I +D +   K+L  L L  N   +       
Sbjct: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV 565

Query: 532 LINLKYLDLGKNQIKKIPA-SISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQ 590
            ++L+ L +     K I   S+  M +L  L L     E  P  + +L NLQ +DL +N 
Sbjct: 566 GVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNN 625

Query: 591 LQKISSDIC--NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELS 648
           L+ I   I   +L  +  L    N   + PI++  L +LE+L +++    K+ ++P +L 
Sbjct: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR---NKIEKIPTQLF 682

Query: 649 NMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNN 708
              +L+ LD+S+N +  +P +IG L+NL +L    N+I  LPP L     L+ L+L  N 
Sbjct: 683 YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNV 742

Query: 709 LTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
           L +LPS +  + +L +I    N L   PVE+
Sbjct: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVEL 773



 Score =  100 bits (249), Expect = 6e-21
 Identities = 106/391 (27%), Positives = 173/391 (44%), Gaps = 25/391 (6%)

Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367
           L+L   ++S +P  + +L  LE L ++      +   I QL  +KEL L     ++ +  
Sbjct: 428 LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPA 487

Query: 368 IENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVN 426
           +   RE LR L +    +K IP  I     LE L L+ N   E  +YI  ++ LR+L   
Sbjct: 488 LAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYI-VIDGLREL--- 543

Query: 427 RNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL 486
               +K+    S+L+ +        ++TDV + ++     + I     K++     L  +
Sbjct: 544 --KRLKVLRLKSNLSKL------PQVVTDVGVHLQK----LSINNEGTKLIVLN-SLKKM 590

Query: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDLGKNQ 544
            +L  L +    +  IP  I     L  ++L +N L    E   F  L  L  L L  N 
Sbjct: 591 ANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650

Query: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI 604
           I  IP  I N+ +L  L L  NK E  P +L     L+ LDLS N L  + +DI  L+ +
Sbjct: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL 710

Query: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR 664
           Q L  ++N+    P EL Q + L  L++       L  LP  +  +T L ++++  N + 
Sbjct: 711 QNLAITANRIETLPPELFQCRKLRALHLGN---NVLQSLPSRVGELTNLTQIELRGNRLE 767

Query: 665 EIPRNIGE--LRNLVSLHAYNNQISYLPPSL 693
            +P  +GE  L     L    +  + LPP +
Sbjct: 768 CLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 72/271 (26%), Positives = 128/271 (47%), Gaps = 28/271 (10%)

Query: 197 ENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP--SDLE 254
           EN    +   ++ L  L++L +  N +S +P+ ++ +G   Q    NN        + L+
Sbjct: 530 ENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588

Query: 255 CLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTG 312
            + NL  L L +  L  IP ++ SL  L+ ++L+ N L T  + + F  L +L  L L  
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648

Query: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFR 372
           N I+ +P +I  L NLE L ++ NK+  +  ++F   K++ L L+ N L           
Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT---------- 698

Query: 373 ELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK 432
               L  D  LL+N          L+ L+++ N++  LP  + +   LR LH+  N +  
Sbjct: 699 ---FLPADIGLLQN----------LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQS 745

Query: 433 ITDCISHLNNICSLEFSGNIITDVPIEIKNC 463
           +   +  L N+  +E  GN +  +P+E+  C
Sbjct: 746 LPSRVGELTNLTQIELRGNRLECLPVELGEC 776



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 59/187 (31%), Positives = 97/187 (51%), Gaps = 4/187 (2%)

Query: 187 LLGLEILSLQENGLSSLPSEI--QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
           L  L+ + L++N L ++   I  Q LH L  L + +NHI++IP +I  L N+ +L+   N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672

Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
            IE  P+ L     L  L L  N L  +P  +  L+ L+ L +  N++ T P  L    K
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732

Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQ--LLKIKELQLADNKLE 362
           L +L L  N++ SLP  + EL NL  + +  N+L  L VE+ +  LLK   L + ++   
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792

Query: 363 VISHKIE 369
            +  +++
Sbjct: 793 TLPPEVK 799



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 72/261 (27%), Positives = 127/261 (48%), Gaps = 7/261 (2%)

Query: 143 NFTVNLEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGA-DSGDLLGLEILSLQENGL 200
           + T NL A+  +    D L+ +K +K L L  N  K  Q   D G  + L+ LS+   G 
Sbjct: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQKLSINNEGT 579

Query: 201 SSLP-SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS--DLECLG 257
             +  + ++ + NL  L +    +  IP  I  L N++++   +N ++        + L 
Sbjct: 580 KLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH 639

Query: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317
            L  L L  N + +IP  + +L  L  L L  N++   P  L +  KL  LDL+ N ++ 
Sbjct: 640 RLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699

Query: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377
           LP +I  L+NL+ L +  N++  L  E+FQ  K++ L L +N L+ +  ++     L  +
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759

Query: 378 ILDKNLLKNIPEKISCCAMLE 398
            L  N L+ +P ++  C +L+
Sbjct: 760 ELRGNRLECLPVELGECPLLK 780


>gi|187829877 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  106 bits (264), Expect = 1e-22
 Identities = 96/372 (25%), Positives = 170/372 (45%), Gaps = 36/372 (9%)

Query: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK-N 327
           L  IPDT+  L  L VL LE     T P ++  L  L  L L           +  L+ N
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494

Query: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQL-----ADNKLEVISHKIENFRELRILILDKN 382
           L  L +    +  + + I+ L  ++EL L     A+N   ++   +   + L++L L  N
Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554

Query: 383 LLKNIPEKISCCAM-LECLSLSDN--KLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439
           L K +P+ ++   + L+ LS+++   KL  L   + K+ NL +L + R ++ +I   I  
Sbjct: 555 LSK-LPQVVTDVGVHLQKLSINNEGTKLIVLNS-LKKMANLTELELIRCDLERIPHSIFS 612

Query: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497
           L+N+  ++   N +  +   I  ++  ++  ++L YN I Y P+ +  L +L  L +N N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672

Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
            I +IP  + + ++L                       +YLDL  N +  +PA I  + +
Sbjct: 673 KIEKIPTQLFYCRKL-----------------------RYLDLSHNNLTFLPADIGLLQN 709

Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
           L  L +  N+ ET P EL     L+ L L  N LQ + S +  L  + ++    N+    
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769

Query: 618 PIELCQLQSLEQ 629
           P+EL +   L++
Sbjct: 770 PVELGECPLLKR 781



 Score =  103 bits (257), Expect = 7e-22
 Identities = 129/511 (25%), Positives = 212/511 (41%), Gaps = 38/511 (7%)

Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
           Y+ N   D++C  ++E L+      R      P     ++L   Y  L  F   +C    
Sbjct: 285 YVHNIKFDVDCTVDIESLT----GYRTYRCAHPLATLFKILASFYISLVIFYGLICMYT- 339

Query: 305 LISLDLTGNLISSLPK----EIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360
                L   L  SL K     IRE  +   +    N   F+   I Q   +   + A   
Sbjct: 340 -----LWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFL 394

Query: 361 LEVISHKIENFRELRILILDK---NLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKL 417
            EV  +K+          LDK    L KN  +K+     +         L+ +P  +  L
Sbjct: 395 SEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFM---------LSGIPDTVFDL 445

Query: 418 NNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT-DVPIEIKNCQKIIKIELSYNKI 476
             L  L +     V I   I+ L  +  L         + P      + +  + + +  I
Sbjct: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505

Query: 477 MYFPLGLCALDSLYYLSVNGNYISE----IPVD-ISFSKQLLHLELSENKLLIFSEHFCS 531
              PL + +L +L  L + GN  +E    I +D +   K+L  L L  N   +       
Sbjct: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV 565

Query: 532 LINLKYLDLGKNQIKKIPA-SISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQ 590
            ++L+ L +     K I   S+  M +L  L L     E  P  + +L NLQ +DL +N 
Sbjct: 566 GVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNN 625

Query: 591 LQKISSDIC--NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELS 648
           L+ I   I   +L  +  L    N   + PI++  L +LE+L +++    K+ ++P +L 
Sbjct: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR---NKIEKIPTQLF 682

Query: 649 NMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNN 708
              +L+ LD+S+N +  +P +IG L+NL +L    N+I  LPP L     L+ L+L  N 
Sbjct: 683 YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNV 742

Query: 709 LTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
           L +LPS +  + +L +I    N L   PVE+
Sbjct: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVEL 773



 Score =  100 bits (249), Expect = 6e-21
 Identities = 106/391 (27%), Positives = 173/391 (44%), Gaps = 25/391 (6%)

Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367
           L+L   ++S +P  + +L  LE L ++      +   I QL  +KEL L     ++ +  
Sbjct: 428 LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPA 487

Query: 368 IENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVN 426
           +   RE LR L +    +K IP  I     LE L L+ N   E  +YI  ++ LR+L   
Sbjct: 488 LAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYI-VIDGLREL--- 543

Query: 427 RNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL 486
               +K+    S+L+ +        ++TDV + ++     + I     K++     L  +
Sbjct: 544 --KRLKVLRLKSNLSKL------PQVVTDVGVHLQK----LSINNEGTKLIVLN-SLKKM 590

Query: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDLGKNQ 544
            +L  L +    +  IP  I     L  ++L +N L    E   F  L  L  L L  N 
Sbjct: 591 ANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650

Query: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI 604
           I  IP  I N+ +L  L L  NK E  P +L     L+ LDLS N L  + +DI  L+ +
Sbjct: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL 710

Query: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR 664
           Q L  ++N+    P EL Q + L  L++       L  LP  +  +T L ++++  N + 
Sbjct: 711 QNLAITANRIETLPPELFQCRKLRALHLGN---NVLQSLPSRVGELTNLTQIELRGNRLE 767

Query: 665 EIPRNIGE--LRNLVSLHAYNNQISYLPPSL 693
            +P  +GE  L     L    +  + LPP +
Sbjct: 768 CLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 72/271 (26%), Positives = 128/271 (47%), Gaps = 28/271 (10%)

Query: 197 ENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP--SDLE 254
           EN    +   ++ L  L++L +  N +S +P+ ++ +G   Q    NN        + L+
Sbjct: 530 ENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588

Query: 255 CLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTG 312
            + NL  L L +  L  IP ++ SL  L+ ++L+ N L T  + + F  L +L  L L  
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648

Query: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFR 372
           N I+ +P +I  L NLE L ++ NK+  +  ++F   K++ L L+ N L           
Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT---------- 698

Query: 373 ELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK 432
               L  D  LL+N          L+ L+++ N++  LP  + +   LR LH+  N +  
Sbjct: 699 ---FLPADIGLLQN----------LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQS 745

Query: 433 ITDCISHLNNICSLEFSGNIITDVPIEIKNC 463
           +   +  L N+  +E  GN +  +P+E+  C
Sbjct: 746 LPSRVGELTNLTQIELRGNRLECLPVELGEC 776



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 59/187 (31%), Positives = 97/187 (51%), Gaps = 4/187 (2%)

Query: 187 LLGLEILSLQENGLSSLPSEI--QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
           L  L+ + L++N L ++   I  Q LH L  L + +NHI++IP +I  L N+ +L+   N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672

Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
            IE  P+ L     L  L L  N L  +P  +  L+ L+ L +  N++ T P  L    K
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732

Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQ--LLKIKELQLADNKLE 362
           L +L L  N++ SLP  + EL NL  + +  N+L  L VE+ +  LLK   L + ++   
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792

Query: 363 VISHKIE 369
            +  +++
Sbjct: 793 TLPPEVK 799



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 72/261 (27%), Positives = 127/261 (48%), Gaps = 7/261 (2%)

Query: 143 NFTVNLEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGA-DSGDLLGLEILSLQENGL 200
           + T NL A+  +    D L+ +K +K L L  N  K  Q   D G  + L+ LS+   G 
Sbjct: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQKLSINNEGT 579

Query: 201 SSLP-SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS--DLECLG 257
             +  + ++ + NL  L +    +  IP  I  L N++++   +N ++        + L 
Sbjct: 580 KLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH 639

Query: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317
            L  L L  N + +IP  + +L  L  L L  N++   P  L +  KL  LDL+ N ++ 
Sbjct: 640 RLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699

Query: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377
           LP +I  L+NL+ L +  N++  L  E+FQ  K++ L L +N L+ +  ++     L  +
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759

Query: 378 ILDKNLLKNIPEKISCCAMLE 398
            L  N L+ +P ++  C +L+
Sbjct: 760 ELRGNRLECLPVELGECPLLK 780


>gi|187829871 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  106 bits (264), Expect = 1e-22
 Identities = 96/372 (25%), Positives = 170/372 (45%), Gaps = 36/372 (9%)

Query: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK-N 327
           L  IPDT+  L  L VL LE     T P ++  L  L  L L           +  L+ N
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494

Query: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQL-----ADNKLEVISHKIENFRELRILILDKN 382
           L  L +    +  + + I+ L  ++EL L     A+N   ++   +   + L++L L  N
Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554

Query: 383 LLKNIPEKISCCAM-LECLSLSDN--KLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439
           L K +P+ ++   + L+ LS+++   KL  L   + K+ NL +L + R ++ +I   I  
Sbjct: 555 LSK-LPQVVTDVGVHLQKLSINNEGTKLIVLNS-LKKMANLTELELIRCDLERIPHSIFS 612

Query: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497
           L+N+  ++   N +  +   I  ++  ++  ++L YN I Y P+ +  L +L  L +N N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672

Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
            I +IP  + + ++L                       +YLDL  N +  +PA I  + +
Sbjct: 673 KIEKIPTQLFYCRKL-----------------------RYLDLSHNNLTFLPADIGLLQN 709

Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
           L  L +  N+ ET P EL     L+ L L  N LQ + S +  L  + ++    N+    
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769

Query: 618 PIELCQLQSLEQ 629
           P+EL +   L++
Sbjct: 770 PVELGECPLLKR 781



 Score =  103 bits (257), Expect = 7e-22
 Identities = 129/511 (25%), Positives = 212/511 (41%), Gaps = 38/511 (7%)

Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
           Y+ N   D++C  ++E L+      R      P     ++L   Y  L  F   +C    
Sbjct: 285 YVHNIKFDVDCTVDIESLT----GYRTYRCAHPLATLFKILASFYISLVIFYGLICMYT- 339

Query: 305 LISLDLTGNLISSLPK----EIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360
                L   L  SL K     IRE  +   +    N   F+   I Q   +   + A   
Sbjct: 340 -----LWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFL 394

Query: 361 LEVISHKIENFRELRILILDK---NLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKL 417
            EV  +K+          LDK    L KN  +K+     +         L+ +P  +  L
Sbjct: 395 SEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFM---------LSGIPDTVFDL 445

Query: 418 NNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT-DVPIEIKNCQKIIKIELSYNKI 476
             L  L +     V I   I+ L  +  L         + P      + +  + + +  I
Sbjct: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505

Query: 477 MYFPLGLCALDSLYYLSVNGNYISE----IPVD-ISFSKQLLHLELSENKLLIFSEHFCS 531
              PL + +L +L  L + GN  +E    I +D +   K+L  L L  N   +       
Sbjct: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV 565

Query: 532 LINLKYLDLGKNQIKKIPA-SISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQ 590
            ++L+ L +     K I   S+  M +L  L L     E  P  + +L NLQ +DL +N 
Sbjct: 566 GVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNN 625

Query: 591 LQKISSDIC--NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELS 648
           L+ I   I   +L  +  L    N   + PI++  L +LE+L +++    K+ ++P +L 
Sbjct: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR---NKIEKIPTQLF 682

Query: 649 NMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNN 708
              +L+ LD+S+N +  +P +IG L+NL +L    N+I  LPP L     L+ L+L  N 
Sbjct: 683 YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNV 742

Query: 709 LTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
           L +LPS +  + +L +I    N L   PVE+
Sbjct: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVEL 773



 Score =  100 bits (249), Expect = 6e-21
 Identities = 106/391 (27%), Positives = 173/391 (44%), Gaps = 25/391 (6%)

Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367
           L+L   ++S +P  + +L  LE L ++      +   I QL  +KEL L     ++ +  
Sbjct: 428 LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPA 487

Query: 368 IENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVN 426
           +   RE LR L +    +K IP  I     LE L L+ N   E  +YI  ++ LR+L   
Sbjct: 488 LAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYI-VIDGLREL--- 543

Query: 427 RNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL 486
               +K+    S+L+ +        ++TDV + ++     + I     K++     L  +
Sbjct: 544 --KRLKVLRLKSNLSKL------PQVVTDVGVHLQK----LSINNEGTKLIVLN-SLKKM 590

Query: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDLGKNQ 544
            +L  L +    +  IP  I     L  ++L +N L    E   F  L  L  L L  N 
Sbjct: 591 ANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650

Query: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI 604
           I  IP  I N+ +L  L L  NK E  P +L     L+ LDLS N L  + +DI  L+ +
Sbjct: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL 710

Query: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR 664
           Q L  ++N+    P EL Q + L  L++       L  LP  +  +T L ++++  N + 
Sbjct: 711 QNLAITANRIETLPPELFQCRKLRALHLGN---NVLQSLPSRVGELTNLTQIELRGNRLE 767

Query: 665 EIPRNIGE--LRNLVSLHAYNNQISYLPPSL 693
            +P  +GE  L     L    +  + LPP +
Sbjct: 768 CLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 72/271 (26%), Positives = 128/271 (47%), Gaps = 28/271 (10%)

Query: 197 ENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP--SDLE 254
           EN    +   ++ L  L++L +  N +S +P+ ++ +G   Q    NN        + L+
Sbjct: 530 ENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588

Query: 255 CLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTG 312
            + NL  L L +  L  IP ++ SL  L+ ++L+ N L T  + + F  L +L  L L  
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648

Query: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFR 372
           N I+ +P +I  L NLE L ++ NK+  +  ++F   K++ L L+ N L           
Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT---------- 698

Query: 373 ELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK 432
               L  D  LL+N          L+ L+++ N++  LP  + +   LR LH+  N +  
Sbjct: 699 ---FLPADIGLLQN----------LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQS 745

Query: 433 ITDCISHLNNICSLEFSGNIITDVPIEIKNC 463
           +   +  L N+  +E  GN +  +P+E+  C
Sbjct: 746 LPSRVGELTNLTQIELRGNRLECLPVELGEC 776



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 59/187 (31%), Positives = 97/187 (51%), Gaps = 4/187 (2%)

Query: 187 LLGLEILSLQENGLSSLPSEI--QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
           L  L+ + L++N L ++   I  Q LH L  L + +NHI++IP +I  L N+ +L+   N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672

Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
            IE  P+ L     L  L L  N L  +P  +  L+ L+ L +  N++ T P  L    K
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732

Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQ--LLKIKELQLADNKLE 362
           L +L L  N++ SLP  + EL NL  + +  N+L  L VE+ +  LLK   L + ++   
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792

Query: 363 VISHKIE 369
            +  +++
Sbjct: 793 TLPPEVK 799



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 72/261 (27%), Positives = 127/261 (48%), Gaps = 7/261 (2%)

Query: 143 NFTVNLEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGA-DSGDLLGLEILSLQENGL 200
           + T NL A+  +    D L+ +K +K L L  N  K  Q   D G  + L+ LS+   G 
Sbjct: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQKLSINNEGT 579

Query: 201 SSLP-SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS--DLECLG 257
             +  + ++ + NL  L +    +  IP  I  L N++++   +N ++        + L 
Sbjct: 580 KLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH 639

Query: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317
            L  L L  N + +IP  + +L  L  L L  N++   P  L +  KL  LDL+ N ++ 
Sbjct: 640 RLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699

Query: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377
           LP +I  L+NL+ L +  N++  L  E+FQ  K++ L L +N L+ +  ++     L  +
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759

Query: 378 ILDKNLLKNIPEKISCCAMLE 398
            L  N L+ +P ++  C +L+
Sbjct: 760 ELRGNRLECLPVELGECPLLK 780


>gi|197333706 leucine rich repeat containing 8 family, member D
           [Homo sapiens]
          Length = 858

 Score =  105 bits (262), Expect = 2e-22
 Identities = 105/394 (26%), Positives = 184/394 (46%), Gaps = 48/394 (12%)

Query: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-- 257
           LS +P  +  L +L +L +     + IP +ISQ+ N+++L     ++ + P+ +E     
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQEL-----HLCHCPAKVEQTAFS 533

Query: 258 ----NLEILSLGKNKLRHIPDTLPSLKTLRVL------NLEYNQLTTFPKALCFLPKLIS 307
               +L  L +    +  IP  +  LK LR L      N E N++    ++L  L  L  
Sbjct: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGL-ESLRELRHLKI 592

Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAV--EIFQLLKIKELQLADNKLEVIS 365
           L +  NL + +P  I ++    T L+ HN  T L V   + +++ + EL+L + +LE I 
Sbjct: 593 LHVKSNL-TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIP 651

Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKL 423
           H I +   L+ L L  N ++ I E IS   +  L CL L  NK+  +P            
Sbjct: 652 HAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPP----------- 700

Query: 424 HVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGL 483
                        I+H+ N+ SL FS N +  +P+ + + QK+  +++SYN I   P+ +
Sbjct: 701 ------------SITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEI 748

Query: 484 CALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKN 543
             L +L +L + GN +  +P  +    +L  L L +N +    E    L  L  L+L  N
Sbjct: 749 GLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGN 808

Query: 544 QIKKIPASIS--NMISLHVLILCCNKFETFPREL 575
            + ++PA +    M+    L++  + F+T P E+
Sbjct: 809 CLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842



 Score =  102 bits (253), Expect = 2e-21
 Identities = 101/387 (26%), Positives = 167/387 (43%), Gaps = 47/387 (12%)

Query: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVK----------ITDCISHLNNICSLEFSGN 451
           +S+NKL E+           + H++RN   K          + D +  L ++  L+    
Sbjct: 441 VSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELI 500

Query: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL-DSLYYLSVNGNYISEIPVDISFSK 510
               +P +I     + ++ L +            L D L  L V    ++EIP  +   K
Sbjct: 501 PEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLK 560

Query: 511 QLLHLEL-----SENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN----------- 554
            L  L L     SEN  +I  E    L +LK L + K+ + K+P++I++           
Sbjct: 561 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIH 619

Query: 555 --------------MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC- 599
                         M+++  L L   + E  P  + +L NLQ LDL  N ++ I   I  
Sbjct: 620 NDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISF 679

Query: 600 -NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDI 658
            +LK +  L    N+ +  P  +  +++LE L  S     KL  LP  + ++ +L+ LD+
Sbjct: 680 QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSN---NKLESLPVAVFSLQKLRCLDV 736

Query: 659 SNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYN 718
           S N I  IP  IG L+NL  LH   N++  LP  L     L+ LNL  N +T+LP  +  
Sbjct: 737 SYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQ 796

Query: 719 IFSLKEINFDDNPLLRPPVEICKGKQL 745
           +  L ++    N L R P ++ + + L
Sbjct: 797 LSQLTQLELKGNCLDRLPAQLGQCRML 823



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 87/336 (25%), Positives = 155/336 (46%), Gaps = 37/336 (11%)

Query: 191 EILSLQENGLSSLPSEIQ------LLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
           ++ +LQE  L   P++++      L  +LR L+V    ++ IP  +  L N+R+L+   N
Sbjct: 511 QMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN 570

Query: 245 Y-IENFP----SDLECLGNLEILSLGKNKLR---HIPDTLPSLKTLRV------------ 284
              EN        L  L +L+IL +  N  +   +I D  P L  L +            
Sbjct: 571 LNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNS 630

Query: 285 ---------LNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEI--RELKNLETLLM 333
                    L L+  +L   P A+  L  L  LDL  N I ++ + I  + LK L  L +
Sbjct: 631 LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKL 690

Query: 334 DHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISC 393
            HNK+  +   I  +  ++ L  ++NKLE +   + + ++LR L +  N +  IP +I  
Sbjct: 691 WHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGL 750

Query: 394 CAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNII 453
              L+ L ++ NK+  LPK + K   LR L++ +N +  + + +  L+ +  LE  GN +
Sbjct: 751 LQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCL 810

Query: 454 TDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSL 489
             +P ++  C+ + K  L     ++  L L   ++L
Sbjct: 811 DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEAL 846



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 76/276 (27%), Positives = 137/276 (49%), Gaps = 9/276 (3%)

Query: 155 EFPKDILKIKYVKYLYLDKN---QIKTFQGADS-GDLLGLEILSLQENGLSSLPSEIQLL 210
           E P  +  +K ++ LYL  N   +     G +S  +L  L+IL ++ N L+ +PS I  +
Sbjct: 551 EIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDV 609

Query: 211 HNLRILNVSHNHISH--IPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNK 268
                  V HN  +   +   + ++ N+ +L   N  +E  P  +  L NL+ L L  N 
Sbjct: 610 APHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNN 669

Query: 269 LRHIPDTLP--SLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326
           +R I + +    LK L  L L +N++ T P ++  +  L SL  + N + SLP  +  L+
Sbjct: 670 IRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQ 729

Query: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKN 386
            L  L + +N ++ + +EI  L  ++ L +  NK++++  ++    +LR L L +N + +
Sbjct: 730 KLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITS 789

Query: 387 IPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRK 422
           +PEK+   + L  L L  N L  LP  + +   L+K
Sbjct: 790 LPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKK 825



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 99/418 (23%), Positives = 174/418 (41%), Gaps = 77/418 (18%)

Query: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373
           ++S +P  + +L +L+ L ++      +  +I Q+  ++EL L     +V        R+
Sbjct: 478 MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRD 537

Query: 374 LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV-----NRN 428
                                  L CL +    + E+P +++ L NLR+L++     + N
Sbjct: 538 ----------------------HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSEN 575

Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
           N +   + +  L ++  L    N+ T VP  I +    +   + +N            D 
Sbjct: 576 NKMIGLESLRELRHLKILHVKSNL-TKVPSNITDVAPHLTKLVIHN------------DG 622

Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
              L +N          +     +  LEL   +L        SL NL+ LDL  N I+ I
Sbjct: 623 TKLLVLNS---------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTI 673

Query: 549 PASIS--NMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606
              IS  ++  L  L L  NK  T P  +  ++NL+ L  S N+L+ +   + +L+ ++ 
Sbjct: 674 EEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRC 733

Query: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666
           L+ S N     PIE+  LQ+L+ L+I+   G K+  LP +L    +L+ L++  N I  +
Sbjct: 734 LDVSYNNISMIPIEIGLLQNLQHLHIT---GNKVDILPKQLFKCIKLRTLNLGQNCITSL 790

Query: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKE 724
           P  +G+L                       + L QL L GN L  LP+ +     LK+
Sbjct: 791 PEKVGQL-----------------------SQLTQLELKGNCLDRLPAQLGQCRMLKK 825


>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
           sapiens]
          Length = 858

 Score =  105 bits (262), Expect = 2e-22
 Identities = 105/394 (26%), Positives = 184/394 (46%), Gaps = 48/394 (12%)

Query: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-- 257
           LS +P  +  L +L +L +     + IP +ISQ+ N+++L     ++ + P+ +E     
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQEL-----HLCHCPAKVEQTAFS 533

Query: 258 ----NLEILSLGKNKLRHIPDTLPSLKTLRVL------NLEYNQLTTFPKALCFLPKLIS 307
               +L  L +    +  IP  +  LK LR L      N E N++    ++L  L  L  
Sbjct: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGL-ESLRELRHLKI 592

Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAV--EIFQLLKIKELQLADNKLEVIS 365
           L +  NL + +P  I ++    T L+ HN  T L V   + +++ + EL+L + +LE I 
Sbjct: 593 LHVKSNL-TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIP 651

Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKL 423
           H I +   L+ L L  N ++ I E IS   +  L CL L  NK+  +P            
Sbjct: 652 HAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPP----------- 700

Query: 424 HVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGL 483
                        I+H+ N+ SL FS N +  +P+ + + QK+  +++SYN I   P+ +
Sbjct: 701 ------------SITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEI 748

Query: 484 CALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKN 543
             L +L +L + GN +  +P  +    +L  L L +N +    E    L  L  L+L  N
Sbjct: 749 GLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGN 808

Query: 544 QIKKIPASIS--NMISLHVLILCCNKFETFPREL 575
            + ++PA +    M+    L++  + F+T P E+
Sbjct: 809 CLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842



 Score =  102 bits (253), Expect = 2e-21
 Identities = 101/387 (26%), Positives = 167/387 (43%), Gaps = 47/387 (12%)

Query: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVK----------ITDCISHLNNICSLEFSGN 451
           +S+NKL E+           + H++RN   K          + D +  L ++  L+    
Sbjct: 441 VSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELI 500

Query: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL-DSLYYLSVNGNYISEIPVDISFSK 510
               +P +I     + ++ L +            L D L  L V    ++EIP  +   K
Sbjct: 501 PEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLK 560

Query: 511 QLLHLEL-----SENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN----------- 554
            L  L L     SEN  +I  E    L +LK L + K+ + K+P++I++           
Sbjct: 561 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIH 619

Query: 555 --------------MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC- 599
                         M+++  L L   + E  P  + +L NLQ LDL  N ++ I   I  
Sbjct: 620 NDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISF 679

Query: 600 -NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDI 658
            +LK +  L    N+ +  P  +  +++LE L  S     KL  LP  + ++ +L+ LD+
Sbjct: 680 QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSN---NKLESLPVAVFSLQKLRCLDV 736

Query: 659 SNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYN 718
           S N I  IP  IG L+NL  LH   N++  LP  L     L+ LNL  N +T+LP  +  
Sbjct: 737 SYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQ 796

Query: 719 IFSLKEINFDDNPLLRPPVEICKGKQL 745
           +  L ++    N L R P ++ + + L
Sbjct: 797 LSQLTQLELKGNCLDRLPAQLGQCRML 823



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 87/336 (25%), Positives = 155/336 (46%), Gaps = 37/336 (11%)

Query: 191 EILSLQENGLSSLPSEIQ------LLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
           ++ +LQE  L   P++++      L  +LR L+V    ++ IP  +  L N+R+L+   N
Sbjct: 511 QMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN 570

Query: 245 Y-IENFP----SDLECLGNLEILSLGKNKLR---HIPDTLPSLKTLRV------------ 284
              EN        L  L +L+IL +  N  +   +I D  P L  L +            
Sbjct: 571 LNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNS 630

Query: 285 ---------LNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEI--RELKNLETLLM 333
                    L L+  +L   P A+  L  L  LDL  N I ++ + I  + LK L  L +
Sbjct: 631 LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKL 690

Query: 334 DHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISC 393
            HNK+  +   I  +  ++ L  ++NKLE +   + + ++LR L +  N +  IP +I  
Sbjct: 691 WHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGL 750

Query: 394 CAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNII 453
              L+ L ++ NK+  LPK + K   LR L++ +N +  + + +  L+ +  LE  GN +
Sbjct: 751 LQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCL 810

Query: 454 TDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSL 489
             +P ++  C+ + K  L     ++  L L   ++L
Sbjct: 811 DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEAL 846



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 76/276 (27%), Positives = 137/276 (49%), Gaps = 9/276 (3%)

Query: 155 EFPKDILKIKYVKYLYLDKN---QIKTFQGADS-GDLLGLEILSLQENGLSSLPSEIQLL 210
           E P  +  +K ++ LYL  N   +     G +S  +L  L+IL ++ N L+ +PS I  +
Sbjct: 551 EIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDV 609

Query: 211 HNLRILNVSHNHISH--IPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNK 268
                  V HN  +   +   + ++ N+ +L   N  +E  P  +  L NL+ L L  N 
Sbjct: 610 APHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNN 669

Query: 269 LRHIPDTLP--SLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326
           +R I + +    LK L  L L +N++ T P ++  +  L SL  + N + SLP  +  L+
Sbjct: 670 IRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQ 729

Query: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKN 386
            L  L + +N ++ + +EI  L  ++ L +  NK++++  ++    +LR L L +N + +
Sbjct: 730 KLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITS 789

Query: 387 IPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRK 422
           +PEK+   + L  L L  N L  LP  + +   L+K
Sbjct: 790 LPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKK 825



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 99/418 (23%), Positives = 174/418 (41%), Gaps = 77/418 (18%)

Query: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373
           ++S +P  + +L +L+ L ++      +  +I Q+  ++EL L     +V        R+
Sbjct: 478 MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRD 537

Query: 374 LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV-----NRN 428
                                  L CL +    + E+P +++ L NLR+L++     + N
Sbjct: 538 ----------------------HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSEN 575

Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
           N +   + +  L ++  L    N+ T VP  I +    +   + +N            D 
Sbjct: 576 NKMIGLESLRELRHLKILHVKSNL-TKVPSNITDVAPHLTKLVIHN------------DG 622

Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
              L +N          +     +  LEL   +L        SL NL+ LDL  N I+ I
Sbjct: 623 TKLLVLNS---------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTI 673

Query: 549 PASIS--NMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606
              IS  ++  L  L L  NK  T P  +  ++NL+ L  S N+L+ +   + +L+ ++ 
Sbjct: 674 EEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRC 733

Query: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666
           L+ S N     PIE+  LQ+L+ L+I+   G K+  LP +L    +L+ L++  N I  +
Sbjct: 734 LDVSYNNISMIPIEIGLLQNLQHLHIT---GNKVDILPKQLFKCIKLRTLNLGQNCITSL 790

Query: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKE 724
           P  +G+L                       + L QL L GN L  LP+ +     LK+
Sbjct: 791 PEKVGQL-----------------------SQLTQLELKGNCLDRLPAQLGQCRMLKK 825


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  105 bits (261), Expect = 2e-22
 Identities = 120/435 (27%), Positives = 195/435 (44%), Gaps = 64/435 (14%)

Query: 285 LNLEYNQLTTF-PKALCFLPKLISLDLTGNLISSLPKE-IRELKNLETLLMDHNKLTFLA 342
           L+L  N LT   P     L  L  L L+GN +S +P +    L +L+ L++ +N+L  + 
Sbjct: 71  LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130

Query: 343 VE-IFQLLKIKELQLADNKLEVISHK-IENFRELRILILDKNLLKNIPEK-ISCCAMLEC 399
            E +++L  ++ L+L  N + ++  +  E    LR L LD N L  IP + ++    L+ 
Sbjct: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190

Query: 400 LSLSDNKLTELPKY-IHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPI 458
           ++L+ N+++ +P Y    L +L  LH++ N        I HL    S E   N+ T    
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNR-------IQHLGTH-SFEGLHNLET---- 238

Query: 459 EIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH-LEL 517
                     ++L+YNK+  FP+ +  L  L  L  + N I  IP        LL  +  
Sbjct: 239 ----------LDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 288

Query: 518 SENKL-LIFSEHFCSLINLKYLDL-GKNQIKKIPASISNMISLHVLILCCNKFETFPREL 575
            +N +  +    F  L  L  L L G   I++ P  +    SL +L L        P  +
Sbjct: 289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIRLLPSGM 347

Query: 576 C-TLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQ 634
           C  L  L+VL+LS NQ++++ S                        L + Q LE++ +  
Sbjct: 348 CQQLPRLRVLELSHNQIEELPS------------------------LHRCQKLEEIGLQH 383

Query: 635 IKGRKLTRLPGE-LSNMTQLKELDISNNAIREI-PRNIGELRNLVSLHAYNNQISYLPPS 692
               ++  +  +  S ++ L+ LD+S NAIR I P     L +LV L   +NQ++ LP  
Sbjct: 384 ---NRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP-- 438

Query: 693 LLSLNDLQQLNLSGN 707
           L  L  L  L L GN
Sbjct: 439 LAGLGGLMHLKLKGN 453



 Score =  101 bits (251), Expect = 3e-21
 Identities = 97/369 (26%), Positives = 169/369 (45%), Gaps = 38/369 (10%)

Query: 163 IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSE-IQLLHNLRILNVSHN 221
           +++++ L L  N +    G     L  L+IL LQ N L  +P+E +  L +L+ L +  N
Sbjct: 89  LRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDAN 148

Query: 222 HISHIP-KEISQLGNIRQLFFYNNYIENFP-SDLECLGNLEILSLGKNKLRHIPD----- 274
            IS +P +    L ++R L+  +N +   P   L  L  L+ ++L  N++ HIPD     
Sbjct: 149 LISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQN 208

Query: 275 --------------------TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL 314
                               +   L  L  L+L YN+L  FP A+  L +L  L    N 
Sbjct: 209 LTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNN 268

Query: 315 ISSLP-KEIRELKNLETLLMDHNKLTFLAVEIFQLL-KIKELQLADNKLEVISH-KIENF 371
           I ++P K       L+T+    N + F+    FQ L K+  L L +  +++     ++  
Sbjct: 269 IKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGT 327

Query: 372 RELRILILDKNLLKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNM 430
             L IL L +  ++ +P  +      L  L LS N++ ELP  +H+   L ++ +  N +
Sbjct: 328 TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS-LHRCQKLEEIGLQHNRI 386

Query: 431 VKI-TDCISHLNNICSLEFSGNIITDV-PIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
            +I  D  S L+++ +L+ S N I  + P        ++K++L+ N++   P  L  L  
Sbjct: 387 WEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP--LAGLGG 444

Query: 489 LYYLSVNGN 497
           L +L + GN
Sbjct: 445 LMHLKLKGN 453



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 120/410 (29%), Positives = 188/410 (45%), Gaps = 40/410 (9%)

Query: 193 LSLQENGLSSLPSEIQLLHNLRILN---VSHNHISHIP-KEISQLGNIRQLFFYNNYIEN 248
           L L  N L+ L  +  L H+LR L    +S NH+SHIP +  S L +++ L   NN +  
Sbjct: 71  LDLSMNNLTEL--QPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGG 128

Query: 249 FPSD-LECLGNLEILSLGKNKLRHIPD-TLPSLKTLRVLNLEYNQLTTFP-KALCFLPKL 305
            P++ L  L +L+ L L  N +  +P+ +   L +LR L L+ N LT  P +AL  LP L
Sbjct: 129 IPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPAL 188

Query: 306 ISLDLTGNLISSLPK-EIRELKNLETLLMDHNKLTFLAVEIFQ-LLKIKELQLADNKLEV 363
            ++ L  N IS +P    + L +L  L + +N++  L    F+ L  ++ L L  NKL+ 
Sbjct: 189 QAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQE 248

Query: 364 ISHKIENFRELRILILDKNLLKNIPEK-ISCCAMLECLSLSDNKLTELPKYIHKLNNLRK 422
               I     L+ L    N +K IPEK      +L+ +   DN +  + +       L K
Sbjct: 249 FPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGR--SAFQYLPK 306

Query: 423 LHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLG 482
           LH                    +L  +G +      ++K    +  + L+   I   P G
Sbjct: 307 LH--------------------TLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG 346

Query: 483 LC-ALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLL-IFSEHFCSLINLKYLDL 540
           +C  L  L  L ++ N I E+P  +   ++L  + L  N++  I ++ F  L +L+ LDL
Sbjct: 347 MCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDL 405

Query: 541 GKNQIKKI-PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589
             N I+ I P + S + SL  L L  N+  T P  L  L  L  L L  N
Sbjct: 406 SWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP--LAGLGGLMHLKLKGN 453



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 88/368 (23%), Positives = 143/368 (38%), Gaps = 80/368 (21%)

Query: 148 LEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSE 206
           L+   L E P   L  +  ++ + L  N+I         +L  L +L L  N +  L + 
Sbjct: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228

Query: 207 -IQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP--------------- 250
             + LHNL  L++++N +   P  I  LG +++L F+NN I+  P               
Sbjct: 229 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 288

Query: 251 ----------SDLECLGNLEILSL-GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL 299
                     S  + L  L  LSL G   ++  PD L    +L +L L    +   P  +
Sbjct: 289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSGM 347

Query: 300 C-FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIF-QLLKIKELQLA 357
           C  LP+L  L+L+ N I  LP  +   + LE + + HN++  +  + F QL  ++ L L+
Sbjct: 348 CQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLS 406

Query: 358 DNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKL 417
            N +  I                       PE  S    L  L L+DN+LT LP      
Sbjct: 407 WNAIRSIH----------------------PEAFSTLHSLVKLDLTDNQLTTLP------ 438

Query: 418 NNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIM 477
                              ++ L  +  L+  GN+         +  K+  +E+ Y    
Sbjct: 439 -------------------LAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPY-AYQ 478

Query: 478 YFPLGLCA 485
             P G+CA
Sbjct: 479 CCPYGMCA 486



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 68/241 (28%), Positives = 109/241 (45%), Gaps = 11/241 (4%)

Query: 499 ISEIPVDISFSKQLLHLELSENKLLIFSEH-FCSLINLKYLDLGKNQIKKIPA-SISNMI 556
           +S +P D+       +L+LS N L       F  L  L+ L L  N +  IP  + S + 
Sbjct: 57  LSAVPGDLD--PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLY 114

Query: 557 SLHVLILCCNKFETFPRE-LCTLENLQVLDLSENQLQKISS-DICNLKGIQKLNFSSNQF 614
           SL +L+L  N+    P E L  L +LQ L L  N +  +       L  ++ L    N  
Sbjct: 115 SLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 174

Query: 615 IHFPIELCQLQSLEQLNISQIKGRKLTRLPG-ELSNMTQLKELDISNNAIREIPRNIGE- 672
              P+    L +L  L    +   +++ +P     N+T L  L + NN I+ +  +  E 
Sbjct: 175 TEIPVRA--LNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEG 232

Query: 673 LRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALP-SAIYNIFSLKEINFDDNP 731
           L NL +L    N++   P ++ +L  LQ+L    NN+ A+P  A      L+ I+F DNP
Sbjct: 233 LHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNP 292

Query: 732 L 732
           +
Sbjct: 293 I 293



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 66/223 (29%), Positives = 93/223 (41%), Gaps = 53/223 (23%)

Query: 145 TVNLEAKGLQEFPKDILKIKYVKYLYLDKNQI-----KTFQG------------------ 181
           T++L    LQEFP  I  +  ++ L    N I     K F G                  
Sbjct: 238 TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 297

Query: 182 ---------------------ADSGDLLG---LEILSLQENGLSSLPSEI-QLLHNLRIL 216
                                 +  DL G   LEIL+L   G+  LPS + Q L  LR+L
Sbjct: 298 RSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVL 357

Query: 217 NVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSD-LECLGNLEILSLGKNKLRHI-PD 274
            +SHN I  +P  + +   + ++   +N I    +D    L +L+ L L  N +R I P+
Sbjct: 358 ELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416

Query: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317
              +L +L  L+L  NQLTT P  L  L  L+ L L GNL  S
Sbjct: 417 AFSTLHSLVKLDLTDNQLTTLP--LAGLGGLMHLKLKGNLALS 457


>gi|190014581 leucine rich repeat containing 2 [Homo sapiens]
          Length = 371

 Score =  103 bits (258), Expect = 5e-22
 Identities = 74/247 (29%), Positives = 127/247 (51%), Gaps = 28/247 (11%)

Query: 488 SLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKK 547
           S +   ++G + +E+P  +     L    +S   + I   +      ++ LDL KNQI  
Sbjct: 99  SAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISH 158

Query: 548 IPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN-QLQKISSDICNLKGIQK 606
           +PA I  + +L  L +  N  ++ P EL   ENL+ LD S N +L ++  ++ NLK +  
Sbjct: 159 LPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTF 218

Query: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666
           ++ S+N+F   PI  C L+                        M+ L+ LDIS+N + ++
Sbjct: 219 VDISANKFSSVPI--CVLR------------------------MSNLQWLDISSNNLTDL 252

Query: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFS-LKEI 725
           P++I  L  L S   Y N+++YLP S+L+L  L  L +SG++L  LP+A+ +  + LK +
Sbjct: 253 PQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFV 312

Query: 726 NFDDNPL 732
           +  DNP+
Sbjct: 313 SLMDNPI 319



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 58/212 (27%), Positives = 107/212 (50%), Gaps = 1/212 (0%)

Query: 201 SSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLE 260
           SSLP +     +  +  +S  H + +P  + +  ++R+ +  N  I+  P+ ++    + 
Sbjct: 88  SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMR 147

Query: 261 ILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL-ISSLP 319
           IL L KN++ H+P  +  LK L+ LN+ +N L + P  L     L  LD +GNL +  LP
Sbjct: 148 ILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELP 207

Query: 320 KEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILIL 379
            E+  LK +  + +  NK + + + + ++  ++ L ++ N L  +   I+   EL+  +L
Sbjct: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLL 267

Query: 380 DKNLLKNIPEKISCCAMLECLSLSDNKLTELP 411
            KN L  +P  +     L  L +S + L ELP
Sbjct: 268 YKNKLTYLPYSMLNLKKLTLLVVSGDHLVELP 299



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 65/250 (26%), Positives = 125/250 (50%), Gaps = 10/250 (4%)

Query: 281 TLRVLN-LEYNQLT---TFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHN 336
           ++R+L+ +E N LT   + PK           +L+G   + LP  ++E  +L    + + 
Sbjct: 72  SVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNT 131

Query: 337 KLTFLA--VEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC 394
            +  +   +++FQ ++I  L L  N++  +  +I   + L+ L +  N LK+IP ++  C
Sbjct: 132 LIQIIPTYIQLFQAMRI--LDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDC 189

Query: 395 AMLECLSLSDN-KLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNII 453
             LE L  S N +L ELP  +  L  +  + ++ N    +  C+  ++N+  L+ S N +
Sbjct: 190 ENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNL 249

Query: 454 TDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDI-SFSKQL 512
           TD+P +I   +++    L  NK+ Y P  +  L  L  L V+G+++ E+P  +   S  L
Sbjct: 250 TDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPL 309

Query: 513 LHLELSENKL 522
             + L +N +
Sbjct: 310 KFVSLMDNPI 319



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 2/227 (0%)

Query: 183 DSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFY 242
           D G      +  L     + LP  ++   +LR   +S+  I  IP  I     +R L   
Sbjct: 93  DRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLP 152

Query: 243 NNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYN-QLTTFPKALCF 301
            N I + P+++ CL NL+ L++G N L+ IP  L   + L  L+   N +L   P  L  
Sbjct: 153 KNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSN 212

Query: 302 LPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKL 361
           L ++  +D++ N  SS+P  +  + NL+ L +  N LT L  +I +L +++   L  NKL
Sbjct: 213 LKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKL 272

Query: 362 EVISHKIENFRELRILILDKNLLKNIPEKI-SCCAMLECLSLSDNKL 407
             + + + N ++L +L++  + L  +P  +      L+ +SL DN +
Sbjct: 273 TYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPI 319



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 49/200 (24%), Positives = 97/200 (48%), Gaps = 1/200 (0%)

Query: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIK 461
           LS    TELP  + +  +LR+ +++   +  I   I     +  L+   N I+ +P EI 
Sbjct: 105 LSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIG 164

Query: 462 NCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNY-ISEIPVDISFSKQLLHLELSEN 520
             + + ++ + +N +   P  L   ++L  L  +GN  + E+P ++S  KQ+  +++S N
Sbjct: 165 CLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISAN 224

Query: 521 KLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLEN 580
           K          + NL++LD+  N +  +P  I  +  L   +L  NK    P  +  L+ 
Sbjct: 225 KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKK 284

Query: 581 LQVLDLSENQLQKISSDICN 600
           L +L +S + L ++ + +C+
Sbjct: 285 LTLLVVSGDHLVELPTALCD 304



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 54/199 (27%), Positives = 92/199 (46%), Gaps = 25/199 (12%)

Query: 547 KIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606
           ++P S+     L    +     +  P  +   + +++LDL +NQ+  + ++I  LK +++
Sbjct: 112 ELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKE 171

Query: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666
           LN   N     P EL   ++LE+L+ S     +L  LP ELSN+ Q+  +DIS N     
Sbjct: 172 LNVGFNYLKSIPPELGDCENLERLDCSG--NLELMELPFELSNLKQVTFVDISAN----- 224

Query: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEIN 726
                             + S +P  +L +++LQ L++S NNLT LP  I  +  L+   
Sbjct: 225 ------------------KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFL 266

Query: 727 FDDNPLLRPPVEICKGKQL 745
              N L   P  +   K+L
Sbjct: 267 LYKNKLTYLPYSMLNLKKL 285



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 45/156 (28%), Positives = 80/156 (51%), Gaps = 2/156 (1%)

Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQEN-GLSSLP 204
           ++L    +   P +I  +K +K L +  N +K+    + GD   LE L    N  L  LP
Sbjct: 149 LDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIP-PELGDCENLERLDCSGNLELMELP 207

Query: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264
            E+  L  +  +++S N  S +P  + ++ N++ L   +N + + P D++ L  L+   L
Sbjct: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLL 267

Query: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300
            KNKL ++P ++ +LK L +L +  + L   P ALC
Sbjct: 268 YKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALC 303


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,539,127
Number of Sequences: 37866
Number of extensions: 1222040
Number of successful extensions: 8735
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 221
Number of HSP's that attempted gapping in prelim test: 4247
Number of HSP's gapped (non-prelim): 1947
length of query: 860
length of database: 18,247,518
effective HSP length: 111
effective length of query: 749
effective length of database: 14,044,392
effective search space: 10519249608
effective search space used: 10519249608
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.