BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|238908508 leucine-rich repeat and death domain-containing protein [Homo sapiens] (860 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|238908508 leucine-rich repeat and death domain-containing pro... 1679 0.0 gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 219 1e-56 gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 210 4e-54 gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 192 9e-49 gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 176 6e-44 gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 170 5e-42 gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 170 5e-42 gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 160 4e-39 gi|45827729 scribble isoform b [Homo sapiens] 156 9e-38 gi|45827731 scribble isoform a [Homo sapiens] 156 9e-38 gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 155 2e-37 gi|4503743 flightless I homolog [Homo sapiens] 144 5e-34 gi|37221175 PH domain and leucine rich repeat protein phosphatas... 133 8e-31 gi|65301141 PH domain and leucine rich repeat protein phosphatas... 131 3e-30 gi|19923729 leucine rich repeat containing 8 family, member C [H... 115 1e-25 gi|197333692 leucine rich repeat containing 8 family, member B [... 115 2e-25 gi|21245134 leucine rich repeat containing 8 family, member B [H... 115 2e-25 gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 112 2e-24 gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 112 2e-24 gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 108 2e-23 gi|157694513 leucine-rich repeat-containing G protein-coupled re... 107 5e-23 gi|4507531 toll-like receptor 3 [Homo sapiens] 107 6e-23 gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 106 1e-22 gi|62241040 leucine rich repeat containing 8 family, member A [H... 106 1e-22 gi|187829877 leucine rich repeat containing 8 family, member A [... 106 1e-22 gi|187829871 leucine rich repeat containing 8 family, member A [... 106 1e-22 gi|197333706 leucine rich repeat containing 8 family, member D [... 105 2e-22 gi|34222199 leucine rich repeat containing 8 family, member D [H... 105 2e-22 gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 105 2e-22 gi|190014581 leucine rich repeat containing 2 [Homo sapiens] 103 5e-22 >gi|238908508 leucine-rich repeat and death domain-containing protein [Homo sapiens] Length = 860 Score = 1679 bits (4348), Expect = 0.0 Identities = 860/860 (100%), Positives = 860/860 (100%) Query: 1 MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETHP 60 MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETHP Sbjct: 1 MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETHP 60 Query: 61 RQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHE 120 RQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHE Sbjct: 61 RQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHE 120 Query: 121 TVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQ 180 TVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQ Sbjct: 121 TVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQ 180 Query: 181 GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF 240 GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF Sbjct: 181 GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF 240 Query: 241 FYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300 FYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC Sbjct: 241 FYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300 Query: 301 FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360 FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK Sbjct: 301 FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360 Query: 361 LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL 420 LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL Sbjct: 361 LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL 420 Query: 421 RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP 480 RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP Sbjct: 421 RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP 480 Query: 481 LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDL 540 LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDL Sbjct: 481 LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDL 540 Query: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN Sbjct: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600 Query: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN Sbjct: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660 Query: 661 NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF 720 NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF Sbjct: 661 NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF 720 Query: 721 SLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFE 780 SLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFE Sbjct: 721 SLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFE 780 Query: 781 FLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIG 840 FLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIG Sbjct: 781 FLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIG 840 Query: 841 AYEIMDKITALNLFTRAIKF 860 AYEIMDKITALNLFTRAIKF Sbjct: 841 AYEIMDKITALNLFTRAIKF 860 >gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] Length = 582 Score = 219 bits (557), Expect = 1e-56 Identities = 143/483 (29%), Positives = 254/483 (52%), Gaps = 28/483 (5%) Query: 216 LNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDT 275 L++S I +P I +L + +L+ Y+N +++ P+++ CL NL L+L +N L +PD+ Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164 Query: 276 LPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDH 335 L +LK LR+L+L +N+L P + L L +L L N I+++ K+I+ L L L + Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224 Query: 336 NKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCA 395 NK+ L EI +L + L +A N+LE + +I N ++ L L N L ++P+ I + Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284 Query: 396 MLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITD 455 L L L N+L+ +P+ + K + L +L++ NN+ + + + Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL------------------ 326 Query: 456 VPIEIKNCQKIIKIELSYNKIMYFPL-GLCALDSLYYLSVNGNYISEIPVDI-SFSKQLL 513 + + K+ + L+ N +P+ G ++Y L++ N I++IP I S +K L Sbjct: 327 ----LSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLS 382 Query: 514 HLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPR 573 L + +N+L F + ++ L+L NQ+ KIP +S ++SL VLIL N + P Sbjct: 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPH 442 Query: 574 ELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633 L L L+ LDL EN+L+ + ++I LK +QKL ++NQ P + L +L L + Sbjct: 443 GLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLG 502 Query: 634 QIKGRKLTRLPGELSNMTQLKELDISNNA-IREIPRNIGELRNLVSLHAYNNQISYLPPS 692 + LT LP E+ + L+EL +++N + +P + L + N +S+LPP Sbjct: 503 E---NLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQ 559 Query: 693 LLS 695 +++ Sbjct: 560 IVA 562 Score = 198 bits (504), Expect = 2e-50 Identities = 149/479 (31%), Positives = 231/479 (48%), Gaps = 24/479 (5%) Query: 193 LSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSD 252 L L + + LPS I+ L L L + N + +P E+ L N+ L N + + P Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164 Query: 253 LECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTG 312 L+ L L +L L NKLR IP + L +L L L +N++TT K + L KL L + Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224 Query: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFR 372 N I LP EI EL NL TL + HN+L L EI +I L L N+L + I N Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284 Query: 373 ELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK 432 L L L N L IP ++ C+ LE L+L +N ++ LP+ + L++L KL N++ Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL--LSSLVKL----NSLTL 338 Query: 433 ITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA-LDSLYY 491 +C +FS I + + +N+I P G+ + L Sbjct: 339 ARNCFQLYPVGGPSQFS---------------TIYSLNMEHNRINKIPFGIFSRAKVLSK 383 Query: 492 LSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPAS 551 L++ N ++ +P+D ++ L L+ N+L E L++L+ L L N +KK+P Sbjct: 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHG 443 Query: 552 ISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSS 611 + N+ L L L NK E+ P E+ L++LQ L L+ NQL + I +L + L Sbjct: 444 LGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGE 503 Query: 612 NQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNI 670 N H P E+ L++LE+L ++ L LP EL+ ++L + I N + +P I Sbjct: 504 NLLTHLPEEIGTLENLEELYLND--NPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560 Score = 187 bits (475), Expect = 4e-47 Identities = 132/429 (30%), Positives = 214/429 (49%), Gaps = 6/429 (1%) Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367 LDL+ I LP I+EL L L + NKL L E+ L+ + L L++N L + Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164 Query: 368 IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNR 427 ++N ++LR+L L N L+ IP + L L L N++T + K I L+ L L + Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224 Query: 428 NNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALD 487 N + ++ I L N+ +L+ + N + +P EI NC +I ++L +N+++ P + L Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284 Query: 488 SLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCS-LINLKYLDLGKNQIK 546 SL L + N +S IP ++ L L L N + E S L+ L L L +N + Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344 Query: 547 KIPASISNMIS-LHVLILCCNKFETFPRELCTLEN-LQVLDLSENQLQKISSDICNLKGI 604 P + S ++ L + N+ P + + L L++ +NQL + D + Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSM 404 Query: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR 664 +LN ++NQ P ++ L SLE L +S L +LP L N+ +L+ELD+ N + Sbjct: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSN---NLLKKLPHGLGNLRKLRELDLEENKLE 461 Query: 665 EIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKE 724 +P I L++L L NNQ++ LP + L +L L L N LT LP I + +L+E Sbjct: 462 SLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEE 521 Query: 725 INFDDNPLL 733 + +DNP L Sbjct: 522 LYLNDNPNL 530 Score = 179 bits (453), Expect = 1e-44 Identities = 118/412 (28%), Positives = 198/412 (48%), Gaps = 29/412 (7%) Query: 354 LQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKY 413 L L+ + ++ I+ +L L L N L+++P ++ C L L+LS+N LT LP Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164 Query: 414 IHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSY 473 + L LR L + N + +I + L+++ +L N IT V +IKN K+ + + Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224 Query: 474 NKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLI 533 NKI P + L +L L V N + +P +I Q+ +L+L N+LL + +L Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284 Query: 534 NLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCT---------------- 577 +L L L N++ IP S++ +L L L N T P L + Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344 Query: 578 ---------LENLQVLDLSENQLQKISSDICN-LKGIQKLNFSSNQFIHFPIELCQLQSL 627 + L++ N++ KI I + K + KLN NQ P++ S+ Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSM 404 Query: 628 EQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQIS 687 +LN++ +LT++P ++S + L+ L +SNN ++++P +G LR L L N++ Sbjct: 405 VELNLAT---NQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLE 461 Query: 688 YLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739 LP + L DLQ+L L+ N LT LP I ++ +L + +N L P EI Sbjct: 462 SLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEI 513 Score = 171 bits (434), Expect = 2e-42 Identities = 138/552 (25%), Positives = 250/552 (45%), Gaps = 50/552 (9%) Query: 61 RQNTLESTSSSGRKSKRNEEQKKNLQFSE-----TSTRTGTSQSLSSLTGRTAEYQALVN 115 R+ +++ G++SK E + K + ++ + G + S+ + R Sbjct: 24 REKEAKASGGFGKESKEKEPKTKGKDAKDGKKDSSAAQPGVAFSVDNTIKRPNPAPGTRK 83 Query: 116 FLSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQ 175 S+ V + + EEN +L +L + + P I ++ + LYL N+ Sbjct: 84 KSSNAEVIKELNKCREENSMRL---------DLSKRSIHILPSSIKELTQLTELYLYSNK 134 Query: 176 IKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGN 235 +++ A+ G L+ L L+L EN L+SLP + L LR+L++ HN + IP + +L + Sbjct: 135 LQSLP-AEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDS 193 Query: 236 IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTF 295 + L+ N I D++ L L +LS+ +NK++ +P + L L L++ +NQL Sbjct: 194 LTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHL 253 Query: 296 PKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQ 355 PK + ++ +LDL N + LP I L +L L + +N+L+ + + + ++EL Sbjct: 254 PKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELN 313 Query: 356 LADNKLEVISHKI-------------------------ENFRELRILILDKNLLKNIPEK 390 L +N + + + F + L ++ N + IP Sbjct: 314 LENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFG 373 Query: 391 I-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFS 449 I S +L L++ DN+LT LP ++ +L++ N + KI + +S L ++ L S Sbjct: 374 IFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILS 433 Query: 450 GNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFS 509 N++ +P + N +K+ +++L NK+ P + L L L + N ++ +P I Sbjct: 434 NNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHL 493 Query: 510 KQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFE 569 L HL L EN L E +L NL+ L L N N+ SL + C+K Sbjct: 494 TNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN---------PNLHSLPFELALCSKLS 544 Query: 570 TFPRELCTLENL 581 E C L +L Sbjct: 545 IMSIENCPLSHL 556 Score = 120 bits (301), Expect = 5e-27 Identities = 101/363 (27%), Positives = 164/363 (45%), Gaps = 23/363 (6%) Query: 481 LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDL 540 L C ++ L ++ I +P I QL L L NKL L+NL L L Sbjct: 94 LNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLAL 153 Query: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600 +N + +P S+ N+ L +L L NK P + L++L L L N++ + DI N Sbjct: 154 SENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKN 213 Query: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660 L + L+ N+ P E+ +L +L L+++ +L LP E+ N TQ+ LD+ + Sbjct: 214 LSKLSMLSIRENKIKQLPAEIGELCNLITLDVAH---NQLEHLPKEIGNCTQITNLDLQH 270 Query: 661 NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALP-SAIYNI 719 N + ++P IG L +L L N++S +P SL + L++LNL NN++ LP S + ++ Sbjct: 271 NELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSL 330 Query: 720 FSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNF 779 L + N PV G ++ L R KI IF Sbjct: 331 VKLNSLTLARNCFQLYPV---GGPSQFSTIYSLNMEHNRINKIPFGIFSRAK-------- 379 Query: 780 EFLCQKLNLANSE-TDMPT-----KSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLI 833 + KLN+ +++ T +P S V L+ +Q I + S +SL L + L+ Sbjct: 380 --VLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 437 Query: 834 RAL 836 + L Sbjct: 438 KKL 440 Score = 117 bits (293), Expect = 5e-26 Identities = 77/263 (29%), Positives = 125/263 (47%), Gaps = 3/263 (1%) Query: 518 SENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCT 577 S N +I + C N LDL K I +P+SI + L L L NK ++ P E+ Sbjct: 85 SSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGC 144 Query: 578 LENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKG 637 L NL L LSEN L + + NLK ++ L+ N+ P + +L SL L ++ Sbjct: 145 LVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTL---YLRF 201 Query: 638 RKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLN 697 ++T + ++ N+++L L I N I+++P IGEL NL++L +NQ+ +LP + + Sbjct: 202 NRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT 261 Query: 698 DLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADE 757 + L+L N L LP I N+ SL + N L P + K L + Sbjct: 262 QITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIST 321 Query: 758 RDEKILEKIFKIVANNITETNFE 780 E +L + K+ + + F+ Sbjct: 322 LPESLLSSLVKLNSLTLARNCFQ 344 >gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo sapiens] Length = 560 Score = 210 bits (535), Expect = 4e-54 Identities = 144/474 (30%), Positives = 237/474 (50%), Gaps = 11/474 (2%) Query: 292 LTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKI 351 LT P + +L + L N I +P+EI+ LKN+ L +D N L L + L + Sbjct: 37 LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96 Query: 352 KELQLADNKLEVISHKIENF----RELRILILDKNLLKNIPEKI-SCCAMLECLSLSDNK 406 + L L+ N + S + +F RELR+ D LK IP I LE L L+ N Sbjct: 97 ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTD---LKEIPVVIFKNLHHLELLGLTGNH 153 Query: 407 LTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466 L LPK I LR++++ RN + L + ++ N I +P EI + + Sbjct: 154 LKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGL 213 Query: 467 IKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFS 526 K ++ N + P LC L L ++ N + IP + +++ + LS N+L Sbjct: 214 QKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273 Query: 527 EHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDL 586 C +L L LG + ++ S +++L L L N P ++C L+NL+VL L Sbjct: 274 RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGL 333 Query: 587 SENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE 646 +N++ ++ S++ +L ++ L + N+F+ FP E+ L SLE+L I Q +G KLT +P Sbjct: 334 DDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEH 393 Query: 647 LSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSG 706 + + LKEL I NN + +P ++G + NL L +N + LP ++ L++L L Sbjct: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453 Query: 707 NNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC-KGKQLYTIARYLQRADERD 759 N LT LP + ++ +LK + DNP+ PP E+C +G + I +YL+ R+ Sbjct: 454 NLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNE--AIWKYLKENRNRN 505 Score = 177 bits (448), Expect = 5e-44 Identities = 130/458 (28%), Positives = 219/458 (47%), Gaps = 35/458 (7%) Query: 129 VSEENQKQLGLGADNFT------VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGA 182 + NQ + + FT V+LE ++E P++I ++K ++ LYLDKN +++ A Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89 Query: 183 DSGDLLGLEILSLQENGLSSLP----------SEIQL---------------LHNLRILN 217 G L LE L L N + S E++L LH+L +L Sbjct: 90 -LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLG 148 Query: 218 VSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLP 277 ++ NH+ +PKEI +R+++ N E FP +L L LEI+ L +NK+ IP+ + Sbjct: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIG 208 Query: 278 SLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNK 337 L L+ + N L P +LC +L LDL+ NL+ S+PK EL+ + + + N+ Sbjct: 209 HLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNR 268 Query: 338 LTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAML 397 L + I + + L L + L + LR L L +N L + P +I L Sbjct: 269 LEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNL 328 Query: 398 ECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSL---EFSGNIIT 454 E L L DNK+ +LP + L+ L+ L + N + + + L ++ L + G +T Sbjct: 329 EVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLT 388 Query: 455 DVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514 VP I+ Q + ++ + N + Y P+ L ++ +L L N + ++P I ++ L Sbjct: 389 YVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKE 448 Query: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASI 552 L L +N L E+ SL+NLK L L N +++ P + Sbjct: 449 LRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486 Score = 85.1 bits (209), Expect = 3e-16 Identities = 66/258 (25%), Positives = 110/258 (42%), Gaps = 26/258 (10%) Query: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574 ++ S L + L+ + L NQI++IP I + ++ VL L N + Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89 Query: 575 LCTLENLQVLDLSENQLQKISSDICN-LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633 L L +L+ LDLS N + S + + L +++L P+ + ++L L + Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVI--FKNLHHLELL 147 Query: 634 QIKGRKLTRLPGELSNMTQLKE-----------------------LDISNNAIREIPRNI 670 + G L LP E+ N T+L+E +D+ N I IP I Sbjct: 148 GLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEI 207 Query: 671 GELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDN 730 G L L + +N + LP SL + L L+LS N L ++P + + + EI N Sbjct: 208 GHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGN 267 Query: 731 PLLRPPVEICKGKQLYTI 748 L + P IC+ L+ + Sbjct: 268 RLEKVPRLICRWTSLHLL 285 Score = 72.0 bits (175), Expect = 2e-12 Identities = 52/181 (28%), Positives = 85/181 (46%), Gaps = 27/181 (14%) Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205 ++L L P I +K ++ L LD N+I ++ G L L+IL L N S P Sbjct: 308 LDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLP-SELGSLSKLKILGLTGNEFLSFPE 366 Query: 206 EIQLLHNLRILNVSHNH---ISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEIL 262 E+ L +L L + + ++++P+ I +L ++++L+ NN++E P L + NLE+L Sbjct: 367 EVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVL 426 Query: 263 S-----------------------LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL 299 L N L H+P+ L SL L+VL L N + PK + Sbjct: 427 DCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486 Query: 300 C 300 C Sbjct: 487 C 487 Score = 54.7 bits (130), Expect = 4e-07 Identities = 35/120 (29%), Positives = 63/120 (52%), Gaps = 2/120 (1%) Query: 157 PKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRIL 216 P+ I K++ +K LY++ N ++ + G + LE+L + N L LP I L+ L Sbjct: 391 PEHIRKLQSLKELYIENNHLE-YLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKEL 449 Query: 217 NVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILS-LGKNKLRHIPDT 275 + N ++H+P+ + L N++ L +N +E P ++ GN I L +N+ R+I T Sbjct: 450 RLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNIMAT 509 >gi|95113664 leucine rich repeat containing 1 [Homo sapiens] Length = 524 Score = 192 bits (489), Expect = 9e-49 Identities = 123/369 (33%), Positives = 206/369 (55%), Gaps = 5/369 (1%) Query: 318 LPKEI-RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRI 376 +P+EI R ++LE LL+D N+L L + FQL+K+++L L+DN+++ + +I NF +L Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86 Query: 377 LILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDC 436 L + +N + IPE IS C L+ S N LT LP+ +L NL L VN ++ + + Sbjct: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146 Query: 437 ISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNG 496 I +L N+ SLE N++T +P + +++ +++L N+I P + AL L L ++G Sbjct: 147 IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDG 206 Query: 497 NYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMI 556 N +SE+P +I K LL L++SEN+L E L +L L + +N ++ IP I + Sbjct: 207 NQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLK 266 Query: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616 L +L + N+ P + E+L L L+ENQL + I LK + LN N+ + Sbjct: 267 KLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVS 326 Query: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676 P E+ S L + ++ +LTR+P E+S T+L LD++ N + +P ++ L+ L Sbjct: 327 LPKEIGGCCS---LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-L 382 Query: 677 VSLHAYNNQ 685 +L +NQ Sbjct: 383 KALWLSDNQ 391 Score = 170 bits (430), Expect = 6e-42 Identities = 132/490 (26%), Positives = 228/490 (46%), Gaps = 12/490 (2%) Query: 190 LEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENF 249 LE L L N L LP + L LR L +S N I +P EI+ + +L N I Sbjct: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEI 97 Query: 250 PSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLD 309 P + L++ N L +P++ P L+ L L++ L + P+ + L L SL+ Sbjct: 98 PESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLE 157 Query: 310 LTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIE 369 L NL++ LP + +L+ LE L + +N++ L I LL +K+L L N+L + +I Sbjct: 158 LRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG 217 Query: 370 NFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNN 429 N + L L + +N L+ +PE+IS L L +S N L +P I KL L L V++N Sbjct: 218 NLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNR 277 Query: 430 MVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSL 489 + ++ + + ++ L + N + +P I +K+ + NK++ P + SL Sbjct: 278 LTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSL 337 Query: 490 YYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKK-I 548 V N ++ IP ++S + +L L+++ N+LL +L LK L L NQ + + Sbjct: 338 TVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQSQPLL 396 Query: 549 PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLN 608 + IL C P E ENL EN + +S + N + + +++ Sbjct: 397 TFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVS 456 Query: 609 FSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQ-LKELDISNNAIREIP 667 I + + E+ N ++ R+ T PGEL +M + ++ L NA + + Sbjct: 457 ---------AIRFVEDEKDEEDNETRTLLRRATPHPGELKHMKKTVENLRNDMNAAKGLD 507 Query: 668 RNIGELRNLV 677 N E+ + + Sbjct: 508 SNKNEVNHAI 517 Score = 158 bits (400), Expect = 2e-38 Identities = 109/354 (30%), Positives = 178/354 (50%), Gaps = 4/354 (1%) Query: 387 IPEKISCCAM-LECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICS 445 +PE+I A LE L L N+L ELP+ +L LRKL ++ N + ++ I++ + Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86 Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505 L+ S N I ++P I C+ + + S N + P L +L LSVN + +P + Sbjct: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146 Query: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565 I L LEL EN L + L L+ LDLG N+I +P SI ++ L L L Sbjct: 147 IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDG 206 Query: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625 N+ P+E+ L+NL LD+SEN+L+++ +I L + L S N P + +L+ Sbjct: 207 NQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLK 266 Query: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685 L L + Q +LT+LP + L EL ++ N + +P++IG+L+ L +L+A N+ Sbjct: 267 KLSILKVDQ---NRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK 323 Query: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739 + LP + L + N LT +P+ + L ++ N LL P+ + Sbjct: 324 LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377 Score = 119 bits (299), Expect = 9e-27 Identities = 95/300 (31%), Positives = 138/300 (46%), Gaps = 26/300 (8%) Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505 L N + ++P + K+ K+ LS N+I P + L L V+ N I EIP Sbjct: 41 LLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPES 100 Query: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565 ISF K L + S N L E F L NL L + ++ +P +I N+ +L L L Sbjct: 101 ISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRE 160 Query: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625 N P L L L+ LDL N++ + I L ++ L NQ P E+ L+ Sbjct: 161 NLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLK 220 Query: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685 +L L++S+ +L RLP E+S +T L +L IS N + IP IG+L+ L Sbjct: 221 NLLCLDVSE---NRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKL--------- 268 Query: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745 S+L ++ N LT LP A+ SL E+ +N LL P I K K+L Sbjct: 269 ------SILKVDQ--------NRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKL 314 Score = 110 bits (274), Expect = 7e-24 Identities = 76/245 (31%), Positives = 123/245 (50%), Gaps = 4/245 (1%) Query: 502 IPVDI-SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHV 560 +P +I +++ L L L N+L E F L+ L+ L L N+I+++P I+N + L Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86 Query: 561 LILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIE 620 L + N+ P + + LQV D S N L ++ L+ + L+ + P Sbjct: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146 Query: 621 LCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLH 680 + L +L L +++ LT LP L+ + +L+ELD+ NN I +P +IG L +L L Sbjct: 147 IGNLYNLASL---ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLW 203 Query: 681 AYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC 740 NQ+S LP + +L +L L++S N L LP I + SL ++ N L P I Sbjct: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIG 263 Query: 741 KGKQL 745 K K+L Sbjct: 264 KLKKL 268 Score = 108 bits (269), Expect = 3e-23 Identities = 67/224 (29%), Positives = 112/224 (50%), Gaps = 6/224 (2%) Query: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616 SL L+L N+ P + L L+ L LS+N++Q++ +I N + +L+ S N+ Sbjct: 37 SLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPE 96 Query: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676 P + ++L+ ++ G LTRLP + L L +++ +++ +P NIG L NL Sbjct: 97 IPESISFCKALQ---VADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNL 153 Query: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736 SL N ++YLP SL L L++L+L N + LP +I + LK++ D N L P Sbjct: 154 ASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELP 213 Query: 737 VEICKGKQLYTI---ARYLQRADERDEKILEKIFKIVANNITET 777 EI K L + L+R E + +++ N+ ET Sbjct: 214 QEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLET 257 Score = 77.8 bits (190), Expect = 4e-14 Identities = 72/263 (27%), Positives = 113/263 (42%), Gaps = 51/263 (19%) Query: 121 TVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQ 180 +V ++S Q EN +G + ++ L L P + +++ ++ L L N+I Sbjct: 134 SVNDISLQSLPEN---IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190 Query: 181 GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF 240 + G LL L+ L L N LS LP EI L NL L+VS N + +P+EIS L ++ L Sbjct: 191 ES-IGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLV 249 Query: 241 FYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300 N +E P + L L IL + +N+L +P+ + ++L L L NQL T PK++ Sbjct: 250 ISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIG 309 Query: 301 FLPKLISL----------------------------------------------DLTGNL 314 L KL +L D+ GN Sbjct: 310 KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNR 369 Query: 315 ISSLPKEIRELKNLETLLMDHNK 337 + LP + LK L+ L + N+ Sbjct: 370 LLHLPLSLTALK-LKALWLSDNQ 391 >gi|21361633 leucine rich repeat containing 40 [Homo sapiens] Length = 602 Score = 176 bits (447), Expect = 6e-44 Identities = 143/506 (28%), Positives = 245/506 (48%), Gaps = 52/506 (10%) Query: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI 246 L L +L + +N L+SLPS I+ L NL+ LNVSHN + +P+EI+ L N++ L+ +N + Sbjct: 104 LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNEL 163 Query: 247 ENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLI 306 E L NLE L L N L +P + SL +L LNL N+L + P + + +L Sbjct: 164 TCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLK 223 Query: 307 SLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI-S 365 LD NL+ ++P E+ +++LE L + NKL FL E +KEL + +N++E++ + Sbjct: 224 HLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIEMLEA 282 Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425 +++ + +L L N LK++P++I LE L LS+N ++ LP + L +L+ L + Sbjct: 283 EHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLAL 341 Query: 426 NRNNMVKITDCISHLNNICSLEFSGNIITD---------------VPIEIK-NCQKIIKI 469 N + I I L++ + I D +P E + N II + Sbjct: 342 EGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITL 401 Query: 470 EL---SYNKIMYFPLGLC-ALDSLYYLSVN--GNYISEIPVDISFSKQLL-HLELSENKL 522 ++ S + P + A+ S S+N N + EIP + K+++ ++LS NKL Sbjct: 402 KILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKL 461 Query: 523 LIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQ 582 S C L L +LDL N + +P + +++ L + L N+F+ P L + L+ Sbjct: 462 SFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLE 521 Query: 583 VLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTR 642 + +S NQ+ + +++ +E L ++ L + Sbjct: 522 TILISNNQVGSVDPQ-------------------------KMKMMENLTTLDLQNNDLLQ 556 Query: 643 LPGELSNMTQLKELDISNNAIREIPR 668 +P EL N L+ L + N R +PR Sbjct: 557 IPPELGNCVNLRTLLLDGNPFR-VPR 581 Score = 169 bits (429), Expect = 8e-42 Identities = 140/541 (25%), Positives = 255/541 (47%), Gaps = 48/541 (8%) Query: 235 NIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTT 294 ++ +L NN +++ DL L L +L + N+L +P + L+ L+ LN+ +N+L Sbjct: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142 Query: 295 FPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKEL 354 P+ + L L L L N ++ + + +L NLE L + +N LT + L + L Sbjct: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202 Query: 355 QLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYI 414 L+ N+L+ + +I + L+ L + NLL+ IP +++ LE L L NKL LP++ Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF- 261 Query: 415 HKLNNLRKLHVNRNNMVKI-TDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSY 473 + L++LHV N + + + + HLN+I L+ N + VP EI + + +++LS Sbjct: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSN 321 Query: 474 NKIMYFPLGLCALDSLYYLSVNGNYISEIPVDI---SFSKQLLHLE-------------L 517 N I P L L L +L++ GN + I +I + L +L Sbjct: 322 NDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESA 380 Query: 518 SENKLLIFSE---HFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574 +E + + SE + ++I LK LD Q IP + + + +++ Sbjct: 381 TETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTS----------- 429 Query: 575 LCTLENLQVLDLSENQLQKISSDICNLKG-IQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633 ++ S+NQL +I + LK + ++ S N+ +ELC LQ L L++ Sbjct: 430 ---------INFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDL- 479 Query: 634 QIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSL 693 + L LP E+ ++ +L+ +++S N + +P + + L ++ NNQ+ + P Sbjct: 480 --RNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQK 537 Query: 694 LSL-NDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYL 752 + + +L L+L N+L +P + N +L+ + D NP P I K I YL Sbjct: 538 MKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILM-KGTAAILEYL 596 Query: 753 Q 753 + Sbjct: 597 R 597 Score = 89.0 bits (219), Expect = 2e-17 Identities = 58/175 (33%), Positives = 95/175 (54%), Gaps = 5/175 (2%) Query: 580 NLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRK 639 +L L +S N+LQ ++ D+ L + L+ NQ P + +L++L++LN+S K Sbjct: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSH---NK 139 Query: 640 LTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDL 699 L LP E++N+ LK L + +N + I +L NL L NN ++ +P S SL+ L Sbjct: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSL 199 Query: 700 QQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQR 754 +LNLS N L +LP+ I + LK ++ + N L P E+ + L + YL+R Sbjct: 200 VRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELL--YLRR 252 Score = 53.1 bits (126), Expect = 1e-06 Identities = 30/82 (36%), Positives = 48/82 (58%) Query: 651 TQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLT 710 T L +L ISNN ++ + ++ L L L ++NQ++ LP ++ L +LQ+LN+S N L Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141 Query: 711 ALPSAIYNIFSLKEINFDDNPL 732 LP I N+ +LK + N L Sbjct: 142 ILPEEITNLRNLKCLYLQHNEL 163 Score = 42.0 bits (97), Expect = 0.002 Identities = 38/125 (30%), Positives = 58/125 (46%), Gaps = 5/125 (4%) Query: 629 QLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISY 688 QLN+S GR L+ +P + + + + N E +L L NN++ Sbjct: 40 QLNLS---GRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQS 96 Query: 689 LPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTI 748 L L L L L++ N LT+LPSAI + +L+++N N L P EI + L + Sbjct: 97 LTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCL 156 Query: 749 ARYLQ 753 YLQ Sbjct: 157 --YLQ 159 Score = 33.5 bits (75), Expect = 0.87 Identities = 22/100 (22%), Positives = 48/100 (48%), Gaps = 2/100 (2%) Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSL-P 204 ++L L P+++ + ++ + L N+ K + LE + + N + S+ P Sbjct: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEV-LYRIFTLETILISNNQVGSVDP 535 Query: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244 +++++ NL L++ +N + IP E+ N+R L N Sbjct: 536 QKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575 Score = 32.3 bits (72), Expect = 1.9 Identities = 20/77 (25%), Positives = 35/77 (45%) Query: 145 TVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLP 204 T+NL + P+ + +I ++ + + NQ+ + + L L LQ N L +P Sbjct: 499 TINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIP 558 Query: 205 SEIQLLHNLRILNVSHN 221 E+ NLR L + N Sbjct: 559 PELGNCVNLRTLLLDGN 575 >gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] Length = 1302 Score = 170 bits (431), Expect = 5e-42 Identities = 118/396 (29%), Positives = 188/396 (47%), Gaps = 27/396 (6%) Query: 351 IKELQLADNKLEVISHKIENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409 + L + LE + +I F + L L LD N ++ +P+++ C L LSL DN LT Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83 Query: 410 LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469 LP I L NLR+L V++N I + P IKNC+ + + Sbjct: 84 LPASIANLINLRELDVSKNG-----------------------IQEFPENIKNCKVLTIV 120 Query: 470 ELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHF 529 E S N I P G L +L L +N ++ +P + +L LEL EN+L + + Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180 Query: 530 CSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589 L L+ LDLG N+ ++P + + L + N+ P + +L+ L LD+S+N Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240 Query: 590 QLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSN 649 ++ + I + +Q L SSN P + L+++ L I + +L LP + Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE---NQLMYLPDSIGG 297 Query: 650 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNL 709 + ++ELD S N + +P +IG+L NL + A +N + LPP + S ++ L L N L Sbjct: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357 Query: 710 TALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745 LP + ++ LK IN DN L P K +QL Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393 Score = 154 bits (389), Expect = 3e-37 Identities = 108/399 (27%), Positives = 190/399 (47%), Gaps = 24/399 (6%) Query: 216 LNVSHNHISHIPKEISQLGN-IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274 L+ SH + +PKEI + +L+ N IE P L +L LSL N L +P Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86 Query: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMD 334 ++ +L LR L++ N + FP+ + L ++ + N IS LP +L NL L ++ Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146 Query: 335 HNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC 394 L FL +L K++ L+L +N+L+++ + +L L L N +PE + Sbjct: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206 Query: 395 AMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT 454 + L+ + N+LT +P +I L L L V++NN+ + + IS N+ L S N + Sbjct: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ 266 Query: 455 DVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514 +P I + + I +++ N++MY P + L S+ L + N + +P I Sbjct: 267 QLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG------- 319 Query: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574 L NL+ N ++++P I + ++ VL L NK ET P E Sbjct: 320 ----------------QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363 Query: 575 LCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613 + ++ L+V++LS+N+L+ + L+ + + S NQ Sbjct: 364 MGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402 Score = 150 bits (378), Expect = 6e-36 Identities = 119/424 (28%), Positives = 193/424 (45%), Gaps = 48/424 (11%) Query: 145 TVNLEAKGLQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSL 203 T++ L++ PK+I K ++ LYLD NQI+ + L LSL +N L++L Sbjct: 26 TLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP-KQLFNCQSLHKLSLPDNDLTTL 84 Query: 204 PSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILS 263 P+ I L NLR L+VS N I P+ I + + N I P L NL L Sbjct: 85 PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLY 144 Query: 264 LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIR 323 L L +P L L++L L NQL PK + L +L LDL N + +P+ + Sbjct: 145 LNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE 204 Query: 324 ELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNL 383 +L L+ MD N+LTF+ I L ++ L ++ N +E++ Sbjct: 205 QLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE------------------ 246 Query: 384 LKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNI 443 E IS C L+ L LS N L +LP+ I L N+ L ++ N ++ + D I Sbjct: 247 -----EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI------ 295 Query: 444 CSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503 G +I+ + +++ S+N++ P + L +L + + NY+ ++P Sbjct: 296 ------GGLIS-----------VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338 Query: 504 VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLIL 563 +I K + L L NKL E + LK ++L N++K +P S + + L + L Sbjct: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWL 398 Query: 564 CCNK 567 N+ Sbjct: 399 SDNQ 402 Score = 138 bits (348), Expect = 2e-32 Identities = 91/340 (26%), Positives = 169/340 (49%), Gaps = 7/340 (2%) Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505 L N I ++P ++ NCQ + K+ L N + P + L +L L V+ N I E P + Sbjct: 51 LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPEN 110 Query: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565 I K L +E S N + + F L+NL L L ++ +PA+ + L +L L Sbjct: 111 IKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRE 170 Query: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625 N+ + P+ + L L+ LDL N+ ++ + L G+++ +N+ P + L+ Sbjct: 171 NQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLK 230 Query: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685 L L++S+ + + +S L++L +S+N+++++P IG L+N+ +L NQ Sbjct: 231 QLTYLDVSK---NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287 Query: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745 + YLP S+ L +++L+ S N + ALPS+I + +L+ D N L + P EI K + Sbjct: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347 Query: 746 YTIARYLQRADERDEKILE----KIFKIVANNITETNFEF 781 + + + + E++ + K+ + N + F F Sbjct: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSF 387 >gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] Length = 1371 Score = 170 bits (431), Expect = 5e-42 Identities = 118/396 (29%), Positives = 188/396 (47%), Gaps = 27/396 (6%) Query: 351 IKELQLADNKLEVISHKIENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409 + L + LE + +I F + L L LD N ++ +P+++ C L LSL DN LT Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83 Query: 410 LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469 LP I L NLR+L V++N I + P IKNC+ + + Sbjct: 84 LPASIANLINLRELDVSKNG-----------------------IQEFPENIKNCKVLTIV 120 Query: 470 ELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHF 529 E S N I P G L +L L +N ++ +P + +L LEL EN+L + + Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180 Query: 530 CSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589 L L+ LDLG N+ ++P + + L + N+ P + +L+ L LD+S+N Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240 Query: 590 QLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSN 649 ++ + I + +Q L SSN P + L+++ L I + +L LP + Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE---NQLMYLPDSIGG 297 Query: 650 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNL 709 + ++ELD S N + +P +IG+L NL + A +N + LPP + S ++ L L N L Sbjct: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357 Query: 710 TALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745 LP + ++ LK IN DN L P K +QL Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393 Score = 154 bits (389), Expect = 3e-37 Identities = 108/399 (27%), Positives = 190/399 (47%), Gaps = 24/399 (6%) Query: 216 LNVSHNHISHIPKEISQLGN-IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274 L+ SH + +PKEI + +L+ N IE P L +L LSL N L +P Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86 Query: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMD 334 ++ +L LR L++ N + FP+ + L ++ + N IS LP +L NL L ++ Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146 Query: 335 HNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC 394 L FL +L K++ L+L +N+L+++ + +L L L N +PE + Sbjct: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206 Query: 395 AMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT 454 + L+ + N+LT +P +I L L L V++NN+ + + IS N+ L S N + Sbjct: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ 266 Query: 455 DVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514 +P I + + I +++ N++MY P + L S+ L + N + +P I Sbjct: 267 QLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG------- 319 Query: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574 L NL+ N ++++P I + ++ VL L NK ET P E Sbjct: 320 ----------------QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363 Query: 575 LCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613 + ++ L+V++LS+N+L+ + L+ + + S NQ Sbjct: 364 MGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402 Score = 150 bits (378), Expect = 6e-36 Identities = 119/424 (28%), Positives = 193/424 (45%), Gaps = 48/424 (11%) Query: 145 TVNLEAKGLQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSL 203 T++ L++ PK+I K ++ LYLD NQI+ + L LSL +N L++L Sbjct: 26 TLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP-KQLFNCQSLHKLSLPDNDLTTL 84 Query: 204 PSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILS 263 P+ I L NLR L+VS N I P+ I + + N I P L NL L Sbjct: 85 PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLY 144 Query: 264 LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIR 323 L L +P L L++L L NQL PK + L +L LDL N + +P+ + Sbjct: 145 LNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE 204 Query: 324 ELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNL 383 +L L+ MD N+LTF+ I L ++ L ++ N +E++ Sbjct: 205 QLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE------------------ 246 Query: 384 LKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNI 443 E IS C L+ L LS N L +LP+ I L N+ L ++ N ++ + D I Sbjct: 247 -----EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI------ 295 Query: 444 CSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503 G +I+ + +++ S+N++ P + L +L + + NY+ ++P Sbjct: 296 ------GGLIS-----------VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338 Query: 504 VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLIL 563 +I K + L L NKL E + LK ++L N++K +P S + + L + L Sbjct: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWL 398 Query: 564 CCNK 567 N+ Sbjct: 399 SDNQ 402 Score = 138 bits (348), Expect = 2e-32 Identities = 91/340 (26%), Positives = 169/340 (49%), Gaps = 7/340 (2%) Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505 L N I ++P ++ NCQ + K+ L N + P + L +L L V+ N I E P + Sbjct: 51 LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPEN 110 Query: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565 I K L +E S N + + F L+NL L L ++ +PA+ + L +L L Sbjct: 111 IKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRE 170 Query: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625 N+ + P+ + L L+ LDL N+ ++ + L G+++ +N+ P + L+ Sbjct: 171 NQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLK 230 Query: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685 L L++S+ + + +S L++L +S+N+++++P IG L+N+ +L NQ Sbjct: 231 QLTYLDVSK---NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287 Query: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745 + YLP S+ L +++L+ S N + ALPS+I + +L+ D N L + P EI K + Sbjct: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347 Query: 746 YTIARYLQRADERDEKILE----KIFKIVANNITETNFEF 781 + + + + E++ + K+ + N + F F Sbjct: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSF 387 >gi|16904383 leucine rich repeat containing 7 [Homo sapiens] Length = 1537 Score = 160 bits (406), Expect = 4e-39 Identities = 101/355 (28%), Positives = 176/355 (49%), Gaps = 23/355 (6%) Query: 190 LEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENF 249 LE L L N + LP ++ LR L++ N +S++P I+ L N+++L N ++ F Sbjct: 48 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107 Query: 250 PSDLECLGNLEILSLGKNKLRHIPD-------------------TLPS----LKTLRVLN 286 P +++C L I+ N + +PD LP+ L LR+L Sbjct: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILE 167 Query: 287 LEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIF 346 L N L T PK++ L +L LDL N LP+ + +++NL L MD+N L L I Sbjct: 168 LRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIG 227 Query: 347 QLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNK 406 +L + L ++ N++E + I L L+L N+L+ +P+ I L L + DN+ Sbjct: 228 KLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQ 287 Query: 407 LTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466 LT LP I L+ L + + N + + I +L+++ +L N + ++P EI +C+ + Sbjct: 288 LTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNV 347 Query: 467 IKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENK 521 + L NK+ + P + + L L+++ N + +P + K+L L LS+N+ Sbjct: 348 TVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402 Score = 159 bits (403), Expect = 8e-39 Identities = 108/363 (29%), Positives = 178/363 (49%), Gaps = 4/363 (1%) Query: 384 LKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442 L+ +P+++ + LE L L N++ ELPK + LRKL + N++ + I+ L N Sbjct: 34 LQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93 Query: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502 + L+ S N + + P IK C+ + IE S N I P G L +L L +N ++ + Sbjct: 94 LKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFL 153 Query: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562 P + +L LEL EN L + L L+ LDLG N+ ++P + + +L L Sbjct: 154 PANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELW 213 Query: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622 + N + P + L+ L LD+S+N+++ + DI + ++ L SSN P + Sbjct: 214 MDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIG 273 Query: 623 QLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY 682 L+ L L + +LT LP + N++ L+E D S N + +P IG L +L +L Sbjct: 274 LLKKLTTLKVDD---NQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVD 330 Query: 683 NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKG 742 N + LP + S ++ ++L N L LP I + L+ +N DN L P K Sbjct: 331 ENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKL 390 Query: 743 KQL 745 K+L Sbjct: 391 KEL 393 Score = 155 bits (393), Expect = 1e-37 Identities = 114/402 (28%), Positives = 192/402 (47%), Gaps = 24/402 (5%) Query: 213 LRILNVSHNHISHIPKEISQLGN-IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271 + +L+ SH + +PKE+ + +L+ N IE P L L LS+ N L + Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83 Query: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331 +P T+ SL L+ L++ N + FP+ + L ++ + N IS LP +L NL L Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143 Query: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKI 391 ++ L FL +L+K LRIL L +N LK +P+ + Sbjct: 144 YLNDAFLEFLPANFGRLVK-----------------------LRILELRENHLKTLPKSM 180 Query: 392 SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGN 451 A LE L L +N+ ELP+ + ++ NLR+L ++ N + + I L + L+ S N Sbjct: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240 Query: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQ 511 I V ++I C+ + + LS N + P + L L L V+ N ++ +P I Sbjct: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300 Query: 512 LLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETF 571 L + S N+L L +L+ L + +N + ++P I + ++ V+ L NK E Sbjct: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL 360 Query: 572 PRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613 P E+ ++ L+VL+LS+N+L+ + LK + L S NQ Sbjct: 361 PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402 Score = 135 bits (341), Expect = 1e-31 Identities = 94/367 (25%), Positives = 186/367 (50%), Gaps = 7/367 (1%) Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505 L N I ++P ++ NCQ + K+ + N + P + +L +L L ++ N + E P + Sbjct: 51 LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPEN 110 Query: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565 I K L +E S N + + F L+NL L L ++ +PA+ ++ L +L L Sbjct: 111 IKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRE 170 Query: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625 N +T P+ + L L+ LDL N+ ++ + ++ +++L +N P + +L+ Sbjct: 171 NHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLK 230 Query: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685 L L++S+ ++ + ++S L++L +S+N ++++P +IG L+ L +L +NQ Sbjct: 231 MLVYLDMSK---NRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQ 287 Query: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745 ++ LP ++ +L+ L++ + S N L +LPS I + SL+ + D+N L P EI K + Sbjct: 288 LTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNV 347 Query: 746 YTIARYLQRADERDEKILE----KIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTV 801 ++ + + E+I + ++ + N + F F K A +D +K+ + Sbjct: 348 TVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALI 407 Query: 802 SLSERAH 808 L AH Sbjct: 408 PLQTEAH 414 Score = 135 bits (339), Expect = 2e-31 Identities = 97/378 (25%), Positives = 174/378 (46%), Gaps = 27/378 (7%) Query: 308 LDLTGNLISSLPKEIREL-KNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISH 366 LD + + +PKE+ + LE L +D N++ L ++F +++L + DN L + Sbjct: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86 Query: 367 KIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVN 426 I + L+ L + KN ++ PE I CC L + S N +++LP +L NL +L++N Sbjct: 87 TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146 Query: 427 -----------------------RNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNC 463 N++ + + L + L+ N ++P + Sbjct: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQI 206 Query: 464 QKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLL 523 Q + ++ + N + P + L L YL ++ N I + +DIS + L L LS N L Sbjct: 207 QNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQ 266 Query: 524 IFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQV 583 + L L L + NQ+ +P +I N+ L CN+ E+ P + L +L+ Sbjct: 267 QLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRT 326 Query: 584 LDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRL 643 L + EN L ++ +I + K + ++ SN+ P E+ Q+Q L LN+S +L L Sbjct: 327 LAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSD---NRLKNL 383 Query: 644 PGELSNMTQLKELDISNN 661 P + + +L L +S+N Sbjct: 384 PFSFTKLKELAALWLSDN 401 Score = 123 bits (308), Expect = 8e-28 Identities = 90/306 (29%), Positives = 139/306 (45%), Gaps = 45/306 (14%) Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKT----------------------FQGAD 183 +++ G+QEFP++I K + + N I F A+ Sbjct: 97 LDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPAN 156 Query: 184 SGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYN 243 G L+ L IL L+EN L +LP + L L L++ +N +P+ + Q+ N+R+L+ N Sbjct: 157 FGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDN 216 Query: 244 NYIENFPSDLECLGNLEILSLGKNK-----------------------LRHIPDTLPSLK 280 N ++ P + L L L + KN+ L+ +PD++ LK Sbjct: 217 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLK 276 Query: 281 TLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTF 340 L L ++ NQLT P + L L D + N + SLP I L +L TL +D N L Sbjct: 277 KLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPE 336 Query: 341 LAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECL 400 L EI + + L NKLE + +I ++LR+L L N LKN+P + L L Sbjct: 337 LPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAAL 396 Query: 401 SLSDNK 406 LSDN+ Sbjct: 397 WLSDNQ 402 Score = 84.7 bits (208), Expect = 3e-16 Identities = 71/248 (28%), Positives = 112/248 (45%), Gaps = 32/248 (12%) Query: 117 LSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQI 176 L + GE+ P+V ++ Q L DN LQ P I K+K + YL + KN+I Sbjct: 191 LGNNEFGEL-PEVLDQIQNLRELWMDN-------NALQVLPGSIGKLKMLVYLDMSKNRI 242 Query: 177 KTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNI 236 +T SG LE L L N L LP I LL L L V N ++ +P I L + Sbjct: 243 ETVDMDISG-CEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLL 301 Query: 237 RQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFP 296 + N +E+ PS + L +L L++ +N L +P + S K + V++L N+L Sbjct: 302 EEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKL---- 357 Query: 297 KALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQL 356 LP+EI +++ L L + N+L L +L ++ L L Sbjct: 358 -------------------EFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWL 398 Query: 357 ADNKLEVI 364 +DN+ + + Sbjct: 399 SDNQSKAL 406 >gi|45827729 scribble isoform b [Homo sapiens] Length = 1630 Score = 156 bits (394), Expect = 9e-38 Identities = 108/380 (28%), Positives = 196/380 (51%), Gaps = 5/380 (1%) Query: 307 SLDLTGNLISSLPKEI-RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365 S+D + ++P+EI R ++LE LL+D N+L L F+LL +++L L+DN+++ + Sbjct: 16 SVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLP 75 Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425 ++ NF +L L + +N + IPE I C LE S N L+ LP +L +L L + Sbjct: 76 PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL 135 Query: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA 485 N ++ + + +L N+ +LE N++ +P + K+ +++L N + P L A Sbjct: 136 NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195 Query: 486 LDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQI 545 L +L L ++ N +S +P ++ ++L+ L++SEN+L L+ L L L +N + Sbjct: 196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255 Query: 546 KKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQ 605 +++P I + L +L + N+ + ENL L L+EN L + + L + Sbjct: 256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLT 315 Query: 606 KLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIRE 665 LN N P E + L++ ++ +L LP EL++ T+L LD++ N ++ Sbjct: 316 NLNVDRNHLEALPPE---IGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQS 372 Query: 666 IPRNIGELRNLVSLHAYNNQ 685 +P + L NL +L NQ Sbjct: 373 LPFALTHL-NLKALWLAENQ 391 Score = 155 bits (393), Expect = 1e-37 Identities = 108/354 (30%), Positives = 178/354 (50%), Gaps = 4/354 (1%) Query: 384 LKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442 L+ +PE+I LE L L N+L ELPK +L NLRKL ++ N + ++ +++ Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83 Query: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502 + L+ S N I ++P IK C+ + + S N + P G L SL +L++N + + Sbjct: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143 Query: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562 P D+ L+ LEL EN L L+ L+ LDLG N ++ +P ++ + +L L Sbjct: 144 PGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELW 203 Query: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622 L N+ P EL L L LD+SEN+L+++ +++ L + L S N P + Sbjct: 204 LDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIG 263 Query: 623 QLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY 682 QL+ L L + Q + ++T G+ N L EL ++ N + +PR++G+L L +L+ Sbjct: 264 QLKQLSILKVDQNRLCEVTEAIGDCEN---LSELILTENLLMALPRSLGKLTKLTNLNVD 320 Query: 683 NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736 N + LPP + L L+L N L LP + + L ++ N L P Sbjct: 321 RNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374 Score = 154 bits (388), Expect = 4e-37 Identities = 112/404 (27%), Positives = 194/404 (48%), Gaps = 25/404 (6%) Query: 190 LEILSLQENGLSSLPSEI-QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIEN 248 +E + + L ++P EI + +L L + N + +PK +L N+R+L +N I+ Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73 Query: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308 P ++ L L + +N + IP+++ K L + + N L+ P L L L Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133 Query: 309 DLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368 L + +LP ++ L NL TL + N L L + L+K+++L L N LEV+ + Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193 Query: 369 ENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428 LR L LD+N L +P ++ L CL +S+N+L ELP + L L L +++N Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253 Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488 + ++ D I L + L+ N + +V I +C+ + ++ L+ N +M P L L Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313 Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548 L L+V+ N++ +P +I L L L +N+L + + Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV-----------------------L 350 Query: 549 PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQ 592 P +++ LHVL + N+ ++ P L L NL+ L L+ENQ Q Sbjct: 351 PPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393 Score = 152 bits (385), Expect = 1e-36 Identities = 108/356 (30%), Positives = 172/356 (48%), Gaps = 1/356 (0%) Query: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317 +LE L L N+LR +P L LR L L N++ P + +L+ LD++ N I Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96 Query: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377 +P+ I+ K LE N L+ L QL + L L D L+ + + N L L Sbjct: 97 IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL 156 Query: 378 ILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCI 437 L +NLLK++P +S LE L L N L LP + L NLR+L ++RN + + + Sbjct: 157 ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216 Query: 438 SHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497 +L + L+ S N + ++P E+ + + LS N + P G+ L L L V+ N Sbjct: 217 GNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQN 276 Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557 + E+ I + L L L+EN L+ L L L++ +N ++ +P I ++ Sbjct: 277 RLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336 Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613 L VL L N+ P EL L VLD++ N+LQ + + +L ++ L + NQ Sbjct: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391 Score = 147 bits (370), Expect = 5e-35 Identities = 109/370 (29%), Positives = 177/370 (47%), Gaps = 3/370 (0%) Query: 153 LQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLH 211 LQ P++I + + ++ L LD NQ++ LL L L L +N + LP E+ Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELP-KPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82 Query: 212 NLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271 L L+VS N I IP+ I + F N + P L +L L+L L+ Sbjct: 83 QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA 142 Query: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331 +P + +L L L L N L + P +L FL KL LDL GN + LP + L NL L Sbjct: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202 Query: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKI 391 +D N+L+ L E+ L ++ L +++N+LE + ++ L L+L +NLL+ +P+ I Sbjct: 203 WLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGI 262 Query: 392 SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGN 451 L L + N+L E+ + I NL +L + N ++ + + L + +L N Sbjct: 263 GQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRN 322 Query: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQ 511 + +P EI C + + L N++ P L L+ L V GN + +P ++ Sbjct: 323 HLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALT-HLN 381 Query: 512 LLHLELSENK 521 L L L+EN+ Sbjct: 382 LKALWLAENQ 391 Score = 103 bits (258), Expect = 5e-22 Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 4/248 (1%) Query: 499 ISEIPVDI-SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557 + +P +I +S+ L L L N+L + F L+NL+ L L N+I+++P ++N + Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83 Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617 L L + N P + + L++ D S N L ++ L+ + L + Sbjct: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143 Query: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLV 677 P ++ L +L L +++ L LP LS + +L++LD+ N + +P +G L NL Sbjct: 144 PGDVGNLANLVTL---ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200 Query: 678 SLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPV 737 L NQ+S LPP L +L L L++S N L LP+ + + L ++ N L R P Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260 Query: 738 EICKGKQL 745 I + KQL Sbjct: 261 GIGQLKQL 268 Score = 98.6 bits (244), Expect = 2e-20 Identities = 61/201 (30%), Positives = 106/201 (52%), Gaps = 3/201 (1%) Query: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616 SL L+L N+ P+ L NL+ L LS+N++Q++ ++ N + +L+ S N Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96 Query: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676 P + ++LE I+ G L+RLP + + L L +++ +++ +P ++G L NL Sbjct: 97 IPESIKFCKALE---IADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANL 153 Query: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736 V+L N + LP SL L L+QL+L GN+L LP + + +L+E+ D N L P Sbjct: 154 VTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALP 213 Query: 737 VEICKGKQLYTIARYLQRADE 757 E+ ++L + R +E Sbjct: 214 PELGNLRRLVCLDVSENRLEE 234 >gi|45827731 scribble isoform a [Homo sapiens] Length = 1655 Score = 156 bits (394), Expect = 9e-38 Identities = 108/380 (28%), Positives = 196/380 (51%), Gaps = 5/380 (1%) Query: 307 SLDLTGNLISSLPKEI-RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365 S+D + ++P+EI R ++LE LL+D N+L L F+LL +++L L+DN+++ + Sbjct: 16 SVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLP 75 Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425 ++ NF +L L + +N + IPE I C LE S N L+ LP +L +L L + Sbjct: 76 PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL 135 Query: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA 485 N ++ + + +L N+ +LE N++ +P + K+ +++L N + P L A Sbjct: 136 NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195 Query: 486 LDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQI 545 L +L L ++ N +S +P ++ ++L+ L++SEN+L L+ L L L +N + Sbjct: 196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255 Query: 546 KKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQ 605 +++P I + L +L + N+ + ENL L L+EN L + + L + Sbjct: 256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLT 315 Query: 606 KLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIRE 665 LN N P E + L++ ++ +L LP EL++ T+L LD++ N ++ Sbjct: 316 NLNVDRNHLEALPPE---IGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQS 372 Query: 666 IPRNIGELRNLVSLHAYNNQ 685 +P + L NL +L NQ Sbjct: 373 LPFALTHL-NLKALWLAENQ 391 Score = 155 bits (393), Expect = 1e-37 Identities = 108/354 (30%), Positives = 178/354 (50%), Gaps = 4/354 (1%) Query: 384 LKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442 L+ +PE+I LE L L N+L ELPK +L NLRKL ++ N + ++ +++ Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83 Query: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502 + L+ S N I ++P IK C+ + + S N + P G L SL +L++N + + Sbjct: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143 Query: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562 P D+ L+ LEL EN L L+ L+ LDLG N ++ +P ++ + +L L Sbjct: 144 PGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELW 203 Query: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622 L N+ P EL L L LD+SEN+L+++ +++ L + L S N P + Sbjct: 204 LDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIG 263 Query: 623 QLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY 682 QL+ L L + Q + ++T G+ N L EL ++ N + +PR++G+L L +L+ Sbjct: 264 QLKQLSILKVDQNRLCEVTEAIGDCEN---LSELILTENLLMALPRSLGKLTKLTNLNVD 320 Query: 683 NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736 N + LPP + L L+L N L LP + + L ++ N L P Sbjct: 321 RNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374 Score = 154 bits (388), Expect = 4e-37 Identities = 112/404 (27%), Positives = 194/404 (48%), Gaps = 25/404 (6%) Query: 190 LEILSLQENGLSSLPSEI-QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIEN 248 +E + + L ++P EI + +L L + N + +PK +L N+R+L +N I+ Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73 Query: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308 P ++ L L + +N + IP+++ K L + + N L+ P L L L Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133 Query: 309 DLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368 L + +LP ++ L NL TL + N L L + L+K+++L L N LEV+ + Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193 Query: 369 ENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428 LR L LD+N L +P ++ L CL +S+N+L ELP + L L L +++N Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253 Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488 + ++ D I L + L+ N + +V I +C+ + ++ L+ N +M P L L Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313 Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548 L L+V+ N++ +P +I L L L +N+L + + Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV-----------------------L 350 Query: 549 PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQ 592 P +++ LHVL + N+ ++ P L L NL+ L L+ENQ Q Sbjct: 351 PPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393 Score = 152 bits (385), Expect = 1e-36 Identities = 108/356 (30%), Positives = 172/356 (48%), Gaps = 1/356 (0%) Query: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317 +LE L L N+LR +P L LR L L N++ P + +L+ LD++ N I Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96 Query: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377 +P+ I+ K LE N L+ L QL + L L D L+ + + N L L Sbjct: 97 IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL 156 Query: 378 ILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCI 437 L +NLLK++P +S LE L L N L LP + L NLR+L ++RN + + + Sbjct: 157 ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216 Query: 438 SHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497 +L + L+ S N + ++P E+ + + LS N + P G+ L L L V+ N Sbjct: 217 GNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQN 276 Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557 + E+ I + L L L+EN L+ L L L++ +N ++ +P I ++ Sbjct: 277 RLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336 Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613 L VL L N+ P EL L VLD++ N+LQ + + +L ++ L + NQ Sbjct: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391 Score = 147 bits (370), Expect = 5e-35 Identities = 109/370 (29%), Positives = 177/370 (47%), Gaps = 3/370 (0%) Query: 153 LQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLH 211 LQ P++I + + ++ L LD NQ++ LL L L L +N + LP E+ Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELP-KPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82 Query: 212 NLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271 L L+VS N I IP+ I + F N + P L +L L+L L+ Sbjct: 83 QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA 142 Query: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331 +P + +L L L L N L + P +L FL KL LDL GN + LP + L NL L Sbjct: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202 Query: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKI 391 +D N+L+ L E+ L ++ L +++N+LE + ++ L L+L +NLL+ +P+ I Sbjct: 203 WLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGI 262 Query: 392 SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGN 451 L L + N+L E+ + I NL +L + N ++ + + L + +L N Sbjct: 263 GQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRN 322 Query: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQ 511 + +P EI C + + L N++ P L L+ L V GN + +P ++ Sbjct: 323 HLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALT-HLN 381 Query: 512 LLHLELSENK 521 L L L+EN+ Sbjct: 382 LKALWLAENQ 391 Score = 103 bits (258), Expect = 5e-22 Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 4/248 (1%) Query: 499 ISEIPVDI-SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557 + +P +I +S+ L L L N+L + F L+NL+ L L N+I+++P ++N + Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83 Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617 L L + N P + + L++ D S N L ++ L+ + L + Sbjct: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143 Query: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLV 677 P ++ L +L L +++ L LP LS + +L++LD+ N + +P +G L NL Sbjct: 144 PGDVGNLANLVTL---ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200 Query: 678 SLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPV 737 L NQ+S LPP L +L L L++S N L LP+ + + L ++ N L R P Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260 Query: 738 EICKGKQL 745 I + KQL Sbjct: 261 GIGQLKQL 268 Score = 98.6 bits (244), Expect = 2e-20 Identities = 61/201 (30%), Positives = 106/201 (52%), Gaps = 3/201 (1%) Query: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616 SL L+L N+ P+ L NL+ L LS+N++Q++ ++ N + +L+ S N Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96 Query: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676 P + ++LE I+ G L+RLP + + L L +++ +++ +P ++G L NL Sbjct: 97 IPESIKFCKALE---IADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANL 153 Query: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736 V+L N + LP SL L L+QL+L GN+L LP + + +L+E+ D N L P Sbjct: 154 VTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALP 213 Query: 737 VEICKGKQLYTIARYLQRADE 757 E+ ++L + R +E Sbjct: 214 PELGNLRRLVCLDVSENRLEE 234 >gi|110825984 malignant fibrous histiocytoma amplified sequence 1 [Homo sapiens] Length = 1052 Score = 155 bits (392), Expect = 2e-37 Identities = 108/358 (30%), Positives = 179/358 (50%), Gaps = 30/358 (8%) Query: 397 LECLSLSDNKLTELPKYIHK-LNNLRKLHVNRNNMVKITDCISHL-NNICSLEFSGNIIT 454 +E L+L +N L E+P+ + L +LR L + RN ++ ++ L +++ L+ S N +T Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124 Query: 455 DVPIEIKNC-QKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLL 513 + E+ + +++ K+ LS+N++ P L AL L L V+ N ++ +P +S +L Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184 Query: 514 HLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPR 573 L++ N+L F L+ L+ LD+ N+++ +P IS + +L +L L + T P Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244 Query: 574 ELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633 C L +L+ L L N LQ + + L+ ++ LN SSN F FP L L LE Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLE----- 299 Query: 634 QIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSL 693 EL +S N + +P I L L++L NN+I YLP S+ Sbjct: 300 ---------------------ELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSI 338 Query: 694 LSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARY 751 + L L++L L GN + LP + + DNPL++PP E+C K + IA Y Sbjct: 339 VELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCM-KGIPYIAAY 395 Score = 145 bits (366), Expect = 2e-34 Identities = 101/333 (30%), Positives = 167/333 (50%), Gaps = 17/333 (5%) Query: 185 GDLLG-LEILSLQENGLSSLPSEI-QLLHNLRILNVSHNHISHIPKEI-SQLGNIRQLFF 241 G LG L +L L+ N + LP + +L H+L L+VSHN ++ + E+ S L +R+L Sbjct: 83 GSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNL 142 Query: 242 YNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF 301 +N + P+ L L +LE L + N+L H+PD+L L LR L++++NQLT FP+ L Sbjct: 143 SHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQ 202 Query: 302 LPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKL 361 L L LD++ N + LP++I L+ L+ L + +L L +L ++ L L +N L Sbjct: 203 LVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGL 262 Query: 362 EVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLR 421 + + + + L++L L NL + P + A LE L LS N+LT +P I L L Sbjct: 263 QALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLL 322 Query: 422 KLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPL 481 L ++ N + + D I L + L GN I +P ++ ++ N ++ P Sbjct: 323 TLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPY 382 Query: 482 GLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514 +C + IP ++ K+L H Sbjct: 383 EVC--------------MKGIPYIAAYQKELAH 401 Score = 124 bits (311), Expect = 4e-28 Identities = 94/346 (27%), Positives = 173/346 (50%), Gaps = 7/346 (2%) Query: 351 IKELQLADNKLEVISHKIEN-FRELRILILDKNLLKNIPEKISCCAM-LECLSLSDNKLT 408 I+ L L +N LE + + + LR+L+L +N +P ++ L L +S N+LT Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124 Query: 409 EL-PKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKII 467 L + + L LRKL+++ N + + + L ++ L+ S N + +P + ++ Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184 Query: 468 KIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE 527 +++ +N++ FP L L +L L V+ N + +P DIS + L L LS +L Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244 Query: 528 HFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLS 587 FC L +L+ L L N ++ +PA S + L +L L N FE FP L L L+ L LS Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304 Query: 588 ENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGEL 647 NQL + S I L + L +N+ + P + +L LE+L ++G ++ LP Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEEL---VLQGNQIAVLPDHF 361 Query: 648 SNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSL 693 ++++ I +N + + P + ++ + + AY ++++ P++ Sbjct: 362 GQLSRVGLWKIKDNPLIQPPYEVC-MKGIPYIAAYQKELAHSQPAV 406 Score = 121 bits (303), Expect = 3e-27 Identities = 104/368 (28%), Positives = 156/368 (42%), Gaps = 45/368 (12%) Query: 256 LGNLEILSLGKNKLRHIPDTLPS-LKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL 314 LG++E L+LG N L +P+ L S L +LRVL L N+ P A Sbjct: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPA---------------- 105 Query: 315 ISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFREL 374 ++ L + EL + HN+LT L E+ L REL Sbjct: 106 VAELGHHLTELD------VSHNRLTALGAEVVSAL----------------------REL 137 Query: 375 RILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKIT 434 R L L N L +P ++ A LE L +S N+L LP + L+ LR L V+ N + Sbjct: 138 RKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFP 197 Query: 435 DCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSV 494 + L + L+ S N + +P +I + + + LS ++ P G C L SL L + Sbjct: 198 RQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLML 257 Query: 495 NGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN 554 + N + +P S ++L L LS N F L L+ L L +NQ+ +P+ IS Sbjct: 258 DNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG 317 Query: 555 MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQF 614 + L L L N+ P + L L+ L L NQ+ + L + N Sbjct: 318 LGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPL 377 Query: 615 IHFPIELC 622 I P E+C Sbjct: 378 IQPPYEVC 385 Score = 115 bits (287), Expect = 2e-25 Identities = 92/346 (26%), Positives = 159/346 (45%), Gaps = 26/346 (7%) Query: 210 LHNLRILNVSHNHISHIPKEI-SQLGNIRQLFFYNNYIENFPSDLECLGN-LEILSLGKN 267 L ++ LN+ +N + +P+ + S LG++R L N P + LG+ L L + N Sbjct: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121 Query: 268 KLRHI-PDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326 +L + + + +L+ LR LNL +NQL P L L L LD++ N ++ LP + L Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLS 181 Query: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKN 386 L TL +DHN+LT ++ QL+ ++EL ++ N+L + Sbjct: 182 RLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRL-----------------------RG 218 Query: 387 IPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSL 446 +PE IS L+ L LS +L LP +L +L L ++ N + + S L + L Sbjct: 219 LPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKML 278 Query: 447 EFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDI 506 S N+ + P + + ++ LS N++ P + L L L ++ N I +P I Sbjct: 279 NLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSI 338 Query: 507 SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASI 552 L L L N++ + +HF L + + N + + P + Sbjct: 339 VELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384 Score = 102 bits (254), Expect = 2e-21 Identities = 71/249 (28%), Positives = 116/249 (46%), Gaps = 1/249 (0%) Query: 163 IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNH 222 ++ ++ L L NQ+ A G L LE L + N L+ LP + L LR L+V HN Sbjct: 134 LRELRKLNLSHNQLPALP-AQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQ 192 Query: 223 ISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTL 282 ++ P+++ QL + +L +N + P D+ L L+IL L +L +P L +L Sbjct: 193 LTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASL 252 Query: 283 RVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLA 342 L L+ N L P L +L L+L+ NL P + L LE L + N+LT + Sbjct: 253 ESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVP 312 Query: 343 VEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSL 402 I L ++ L L +N++ + I L L+L N + +P+ + + + Sbjct: 313 SLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKI 372 Query: 403 SDNKLTELP 411 DN L + P Sbjct: 373 KDNPLIQPP 381 Score = 46.6 bits (109), Expect = 1e-04 Identities = 28/95 (29%), Positives = 55/95 (57%), Gaps = 3/95 (3%) Query: 648 SNMTQLKELDISNNAIREIPRNIGE-LRNLVSLHAYNNQISYLPPSLLSL-NDLQQLNLS 705 +N+ ++ L++ NN + E+P +G L +L L N+ + LPP++ L + L +L++S Sbjct: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119 Query: 706 GNNLTALPSAIYN-IFSLKEINFDDNPLLRPPVEI 739 N LTAL + + + + L+++N N L P ++ Sbjct: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQL 154 Score = 46.6 bits (109), Expect = 1e-04 Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 3/138 (2%) Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205 +NL + +EFP +L + ++ LYL +NQ+ + SG L L L L N + LP Sbjct: 278 LNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG-LGRLLTLWLDNNRIRYLPD 336 Query: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLG 265 I L L L + N I+ +P QL + +N + P ++ C+ + ++ Sbjct: 337 SIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV-CMKGIPYIAAY 395 Query: 266 KNKLRHI-PDTLPSLKTL 282 + +L H P P LK L Sbjct: 396 QKELAHSQPAVQPRLKLL 413 >gi|4503743 flightless I homolog [Homo sapiens] Length = 1269 Score = 144 bits (362), Expect = 5e-34 Identities = 105/362 (29%), Positives = 180/362 (49%), Gaps = 25/362 (6%) Query: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI 246 + L L L GL LP E+ L L L+VSHN+++ + E+S L ++R + N + Sbjct: 32 MTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSL 91 Query: 247 EN--FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF-LP 303 +N P D+ L +L +L L N+L P L + K + VLNL +N + T P L L Sbjct: 92 KNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLT 151 Query: 304 KLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEV 363 L+ LDL+ N + SLP ++R L +L+TL+++ N L L ++ QL + LQ Sbjct: 152 DLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPL--LHAQLRQLPAMTALQTLH----- 204 Query: 364 ISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKL 423 L + N+P + + L + LS N LT +P+ ++ L +LR+L Sbjct: 205 -------------LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRL 251 Query: 424 HVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMY--FPL 481 +++ N + +++ CI ++ +L S N +T +P I K+ K+ L+ NK+ + P Sbjct: 252 NLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPS 311 Query: 482 GLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLG 541 G+ L +L N + +P + +L L L++N L+ E L ++ LD+ Sbjct: 312 GIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVR 371 Query: 542 KN 543 +N Sbjct: 372 EN 373 Score = 137 bits (345), Expect = 4e-32 Identities = 110/379 (29%), Positives = 190/379 (50%), Gaps = 20/379 (5%) Query: 388 PEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLE 447 PE + L L L+ L LP+ + L L L V+ NN+ + +S L ++ ++ Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85 Query: 448 FSGNIITD--VPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505 N + + VP +I + ++LS+N++ P L ++ L+++ N I IP Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145 Query: 506 ISFS-KQLLHLELSENKLLIFSEHFCSLINLKYLDLGKN-----QIKKIPASISNMISLH 559 + + LL+L+LSEN+L L++L+ L L N Q++++PA M +L Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA----MTALQ 201 Query: 560 VLILCCNKF--ETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617 L L + P L L NL +DLS N L ++ + L +++LN SSNQ Sbjct: 202 TLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITEL 261 Query: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR--EIPRNIGELRN 675 + + Q +E LN+S+ +LT LP + +++LK+L +++N + +P IG+L N Sbjct: 262 SLCIDQWVHVETLNLSR---NQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTN 318 Query: 676 LVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNP-LLR 734 L A NN + +P SL L++L L+ N+L LP AI+ + ++ ++ +NP L+ Sbjct: 319 LEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVM 378 Query: 735 PPVEICKGKQLYTIARYLQ 753 PP + + Y I LQ Sbjct: 379 PPKPADRAAEWYNIDFSLQ 397 Score = 111 bits (278), Expect = 3e-24 Identities = 84/275 (30%), Positives = 139/275 (50%), Gaps = 5/275 (1%) Query: 142 DNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLS 201 D ++L L E P+++ K + L L N I T +L L L L EN L Sbjct: 105 DLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLE 164 Query: 202 SLPSEIQLLHNLRILNVSHNHISHIP-KEISQLGNIRQLFFYNNYI--ENFPSDLECLGN 258 SLP +++ L +L+ L ++ N + H +++ + ++ L + N P+ LE L N Sbjct: 165 SLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSN 224 Query: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSL 318 L + L N L +P+ L +L +LR LNL NQ+T + + +L+L+ N ++SL Sbjct: 225 LADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSL 284 Query: 319 PKEIRELKNLETLLMDHNKLTF--LAVEIFQLLKIKELQLADNKLEVISHKIENFRELRI 376 P I +L L+ L ++ NKL F L I +L ++E A+N LE++ + +LR Sbjct: 285 PSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRK 344 Query: 377 LILDKNLLKNIPEKISCCAMLECLSLSDNKLTELP 411 L+L+KN L +PE I +E L + +N +P Sbjct: 345 LVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379 >gi|37221175 PH domain and leucine rich repeat protein phosphatase [Homo sapiens] Length = 1205 Score = 133 bits (334), Expect = 8e-31 Identities = 132/502 (26%), Positives = 238/502 (47%), Gaps = 33/502 (6%) Query: 193 LSLQENGLSSLPS--------EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244 L+L++N L PS E+Q L+ LN+S+NH+ P + + + +L N Sbjct: 153 LNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCN 212 Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304 + + P+ + + NL+ L N L+ +P L ++K L L L +N+ T P+ L L Sbjct: 213 ALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTA 272 Query: 305 LISLDLTGNLISSLP----KEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360 + L ++GN + +L +++ +K+++ L KL +A E+ L + +L L DNK Sbjct: 273 VDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKL--IADEVDFLQHVTQLDLRDNK 330 Query: 361 LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL 420 L + I F + +L ++N L + C L+ L S N+L +L Y N L Sbjct: 331 LGDLDAMI--FNNIEVLHCERNQLVTLD---ICGYFLKALYASSNELVQLDVY-PVPNYL 384 Query: 421 RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP 480 + V+RN + + + + + L+ N I ++P + + K+ +N++ P Sbjct: 385 SYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLP 444 Query: 481 LGLCALDSLYYLSVNGNYISEIPVDISF-SKQLLHLELSENKL-----LIFSEHFCSLIN 534 L S+ L V N + E+P ++ + L L S NKL SE S++ Sbjct: 445 ERL-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQ 503 Query: 535 LKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFP-RELCTLENLQVLDLSENQLQK 593 YL K +P ++ L +L + N+ ++FP ++ LE L+ +DLS N+L+ Sbjct: 504 ELYLTNNSLTDKCVPL-LTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKA 562 Query: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQL 653 I + I N + + + SN FP E+ QL ++ +++S + ++T LP L +L Sbjct: 563 IPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVT-LPENLP--PKL 618 Query: 654 KELDISNNAIREIPRNIGELRN 675 +ELD++ N + EL N Sbjct: 619 QELDLTGNPRLVLDHKTLELLN 640 Score = 131 bits (329), Expect = 3e-30 Identities = 135/493 (27%), Positives = 225/493 (45%), Gaps = 80/493 (16%) Query: 246 IENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLK---------TLRVLNLEYNQLTTFP 296 +E+ P++L +L L+L +N LR P +LP+ + L+ LNL N L FP Sbjct: 137 LEHLPANLFYSQDLTHLNLKQNFLRQNP-SLPAARGLNELQRFTKLKSLNLSNNHLGDFP 195 Query: 297 KALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQL 356 A+C +P L L+++ N + S+P + + NL+T L+D N L L E+ Sbjct: 196 LAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAEL----------- 244 Query: 357 ADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHK 416 EN ++L L L N +IPE + ++ L +S N + L + Sbjct: 245 ------------ENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETL-----R 287 Query: 417 LNNLRKL----HVN-RNNMVK--ITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469 L LRK+ HV+ R N+++ I D + L ++ L+ N + D+ I N +++ Sbjct: 288 LQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHC 347 Query: 470 ELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHF 529 E N+++ + L +LY S + PV L ++++S N+L E Sbjct: 348 ER--NQLVTLDICGYFLKALYASSNELVQLDVYPVP----NYLSYMDVSRNRLENVPEWV 401 Query: 530 CSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589 C L+ LD+G NQI ++PA + SL L+ N+ P L +++VLD+ N Sbjct: 402 CESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERL-ERTSVEVLDVQHN 460 Query: 590 QLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSN 649 QL ++ ++ L + SL LN S K L P LS Sbjct: 461 QLLELPPNL----------------------LMKADSLRFLNASANKLESLP--PATLSE 496 Query: 650 MTQ--LKELDISNNAIRE--IPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLS 705 T L+EL ++NN++ + +P G + AYN S+ + L +L++++LS Sbjct: 497 ETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLS 556 Query: 706 GNNLTALPSAIYN 718 GN L A+P+ I N Sbjct: 557 GNKLKAIPTTIMN 569 Score = 82.0 bits (201), Expect = 2e-15 Identities = 91/398 (22%), Positives = 167/398 (41%), Gaps = 38/398 (9%) Query: 412 KYIHKLNNLRKLHVNRNNMVKITDC-ISHL-------NNICSLEFSGNIITDVPI----- 458 +Y+ L + K+ R + V ++ C + HL ++ L N + P Sbjct: 111 EYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAAR 170 Query: 459 ---EIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHL 515 E++ K+ + LS N + FPL +C++ +L L+V+ N + +P + L Sbjct: 171 GLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTF 230 Query: 516 ELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE- 574 L N L ++ L YL L N+ IP + + ++ L + N ET + Sbjct: 231 LLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQA 290 Query: 575 LCTLENLQVLDLSENQLQKISSDICN-LKGIQKLNFSSNQ--------FIHFPIELCQLQ 625 L + +++ +DL N ++K+ +D + L+ + +L+ N+ F + + C+ Sbjct: 291 LRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERN 350 Query: 626 SLEQLNISQIKGRKLTRLPGELSNM------TQLKELDISNNAIREIPRNIGELRNLVSL 679 L L+I + L EL + L +D+S N + +P + E R L L Sbjct: 351 QLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVL 410 Query: 680 HAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLR-PPVE 738 +NQI LP L + L++L N L LP + S++ ++ N LL PP Sbjct: 411 DIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLERT-SVEVLDVQHNQLLELPPNL 469 Query: 739 ICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITE 776 + K L R+L + + E + N+I + Sbjct: 470 LMKADSL----RFLNASANKLESLPPATLSEETNSILQ 503 Score = 55.8 bits (133), Expect = 2e-07 Identities = 41/178 (23%), Positives = 75/178 (42%), Gaps = 17/178 (9%) Query: 568 FETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIE------- 620 F+TF L L QV ++ ++ + C+L+ + F S H ++ Sbjct: 106 FDTFTEYLRWLR--QVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQN 163 Query: 621 --------LCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGE 672 L +LQ +L + L P + ++ L EL++S NA+R +P +G Sbjct: 164 PSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGV 223 Query: 673 LRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDN 730 + NL + N + LP L ++ L L LS N T +P + + ++ ++ N Sbjct: 224 MHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGN 281 >gi|65301141 PH domain and leucine rich repeat protein phosphatase-like [Homo sapiens] Length = 1323 Score = 131 bits (329), Expect = 3e-30 Identities = 153/539 (28%), Positives = 255/539 (47%), Gaps = 42/539 (7%) Query: 216 LNVSHNHISHIPKEISQLGNIRQLFFYNNYIE-NFPSDLECL---GNLEILSLGKNKLRH 271 +++S + +P+ + +I L +N+++ P L+ L L+ L+L NKL Sbjct: 254 VDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGL 313 Query: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331 P L + TL LNL N P + L L +L L GN +++LP+E+ L+ L +L Sbjct: 314 FPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSL 373 Query: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN-FRELRILILDKNLLKN-IPE 389 + N + + +L + + +A N LEV++ + N ++ + L N LK + E Sbjct: 374 GISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIE 433 Query: 390 KISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFS 449 + + + L DN+LT+L + L +L +LH RN + ++T +S + + +L S Sbjct: 434 NLEGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELT--LSGFS-LRTLYAS 488 Query: 450 GNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFS 509 N +T V + + ++LS N + P C + L V+ N ++E+PV I S Sbjct: 489 SNRLTAVNV-YPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSS 547 Query: 510 KQLLHLELSEN---KLLIFSEHFCSLINLKYLDLGKNQIKKIPASI-SNMISLHVLILCC 565 L L L N L EH I L+ LDL N + ++P ++ S ++L L Sbjct: 548 LSLRKLMLGHNHVQNLPTLVEH----IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASA 603 Query: 566 NKFETFPRELCT----LENLQVLDLSENQL--QKISSDICNLKGIQKLNFSSNQFIHFPI 619 N E+ P CT L LQ+L L+ N L Q I + +L ++ L+ ++NQ FP Sbjct: 604 NSLESLP-SACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPA 661 Query: 620 -ELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVS 678 +L +L+ LE+LN+S G KL +P ++N +L L +N I P E+ L Sbjct: 662 SKLNKLEQLEELNLS---GNKLKTIPTTIANCKRLHTLVAHSNNISIFP----EILQLPQ 714 Query: 679 LH----AYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFS-LKEINFDDNPL 732 + + N+ L P L LQ L+L+GN L +IFS + + D PL Sbjct: 715 IQFVDLSCNDLTEILIPEALPAT-LQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPL 772 Score = 122 bits (305), Expect = 2e-27 Identities = 149/571 (26%), Positives = 250/571 (43%), Gaps = 48/571 (8%) Query: 102 SLTGRTAEYQALVNFLSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDIL 161 SL +A QA +S ET+ E + Q + TV+L L+E P+ + Sbjct: 213 SLAFSSAGAQAQTYHVSFETLAEYQRW---QRQASKVVSQRISTVDLSCYSLEEVPEHLF 269 Query: 162 KIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHN 221 + + YL L N + LE + GL +L QL + LN+SHN Sbjct: 270 YSQDITYLNLRHN------------FMQLE----RPGGLDTLYKFSQL----KGLNLSHN 309 Query: 222 HISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKT 281 + P + ++ + +L N + PS + L NL+ L L N L +P+ L +L+ Sbjct: 310 KLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQ 369 Query: 282 LRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEI-RELKNLETLLMDHNKLTF 340 L L + +N + P+ L L + + GN + L + + +++ + + N L Sbjct: 370 LSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKT 429 Query: 341 LAVEIFQLLK-IKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLEC 399 + +E + K I + L DN+L + + + L L +N L+ E L Sbjct: 430 MVIENLEGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLR---ELTLSGFSLRT 484 Query: 400 LSLSDNKLTELPKY-IHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPI 458 L S N+LT + Y + L L L ++RN + + D I L+ S N++T+VP+ Sbjct: 485 LYASSNRLTAVNVYPVPSL--LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPV 542 Query: 459 EIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSK--QLLHLE 516 I + + K+ L +N + P L L L + N ++ +P D FSK L +L Sbjct: 543 RILSSLSLRKLMLGHNHVQNLPT-LVEHIPLEVLDLQHNALTRLP-DTLFSKALNLRYLN 600 Query: 517 LSENKL-----LIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETF 571 S N L E S++ L YL + IP + + + L +L L N+ +TF Sbjct: 601 ASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGH-LHLRILHLANNQLQTF 659 Query: 572 P-RELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQL 630 P +L LE L+ L+LS N+L+ I + I N K + L SN FP ++ L Q+ Sbjct: 660 PASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFP----EILQLPQI 715 Query: 631 NISQIKGRKLTRLPGELSNMTQLKELDISNN 661 + LT + + L++LD++ N Sbjct: 716 QFVDLSCNDLTEILIPEALPATLQDLDLTGN 746 Score = 47.4 bits (111), Expect = 6e-05 Identities = 64/272 (23%), Positives = 108/272 (39%), Gaps = 35/272 (12%) Query: 604 IQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNM---TQLKELDISN 660 I ++ S P L Q + LN+ +L R PG L + +QLK L++S+ Sbjct: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRH-NFMQLER-PGGLDTLYKFSQLKGLNLSH 308 Query: 661 NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF 720 N + P + E+ L L+ N LP + +L +LQ L L GN LT LP + N+ Sbjct: 309 NKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQ 368 Query: 721 SLKEINFDDNPLLRPPVEICKGKQLYTIA-----------------RYLQRADERDEKIL 763 L + N + P K L + +++ D R + Sbjct: 369 QLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLK 428 Query: 764 EKIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSL 823 + + + N T+ + +L TD+ S SL + L + Q +L+L Sbjct: 429 TMVIENLEGNKHITHVDLRDNRL------TDLDLSSLCSLEQ-----LHCGRNQLRELTL 477 Query: 824 TAAALRDQLIRA--LTMIGAYEIMDKITALNL 853 + +LR + LT + Y + +T L+L Sbjct: 478 SGFSLRTLYASSNRLTAVNVYPVPSLLTFLDL 509 >gi|19923729 leucine rich repeat containing 8 family, member C [Homo sapiens] Length = 803 Score = 115 bits (289), Expect = 1e-25 Identities = 105/389 (26%), Positives = 186/389 (47%), Gaps = 38/389 (9%) Query: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-N 258 LS LP + + L+ L + IP I+QL N+++L + ++ + L L N Sbjct: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492 Query: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNL------EYNQLTTFPKALCFLPKLISLDLTG 312 L++LS+ + +R +P + L+ L L L + ++ T ++L L L L + Sbjct: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTL-ESLRDLKSLKILSIKS 551 Query: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAV--EIFQLLKIKELQLADNKLEVISHKIEN 370 N +S +P+ + ++ + + HN T L + + ++ + EL+L LE I H + + Sbjct: 552 N-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFS 610 Query: 371 FRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428 L+ L L +N LK+I E +S + L L L N +T +P++I KL +L +L Sbjct: 611 LLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERL----- 665 Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488 FS N I +P + C KI ++LSYN I + P + L S Sbjct: 666 ------------------SFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQS 707 Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548 L Y S+ N + +P ++ F K+L L++ +N L + S +L+ L YLD+ N + + Sbjct: 708 LQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEIL 767 Query: 549 PASISNMISLH--VLILCCNKFETFPREL 575 P + + +L L++ FET P ++ Sbjct: 768 PPELGDCRALKRAGLVVEDALFETLPSDV 796 Score = 97.4 bits (241), Expect = 5e-20 Identities = 93/375 (24%), Positives = 161/375 (42%), Gaps = 36/375 (9%) Query: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK-N 327 L +PDT+ + L+ L LE + P + L L L L + + LK N Sbjct: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492 Query: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI-----ENFRELRILILDKN 382 L+ L + + + L ++ L ++EL L + IS + + + L+IL + N Sbjct: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN 552 Query: 383 LLKNIPEKI---SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439 + K IP+ + S C+ KL L + K+ NL +L + ++ +I + Sbjct: 553 VSK-IPQAVVDVSSHLQKMCIHNDGTKLVMLNN-LKKMTNLTELELVHCDLERIPHAVFS 610 Query: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497 L ++ L+ N + + + ++ +K+ ++L +N I Y P + L SL LS Sbjct: 611 LLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLS---- 666 Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557 S NK+ + H ++YLDL N I+ IP I + S Sbjct: 667 -------------------FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQS 707 Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617 L + CNK E+ P EL + L+ L + +N L +S I NL + L+ N F Sbjct: 708 LQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEIL 767 Query: 618 PIELCQLQSLEQLNI 632 P EL ++L++ + Sbjct: 768 PPELGDCRALKRAGL 782 Score = 90.1 bits (222), Expect = 8e-18 Identities = 106/441 (24%), Positives = 186/441 (42%), Gaps = 98/441 (22%) Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367 L+L ++S LP + E+ L++L ++ K + I QL ++EL L +++ S Sbjct: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485 Query: 368 IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNR 427 + +E L+ LS+ + + ELP +++ L NL +L+ Sbjct: 486 LSFLKE----------------------NLKVLSVKFDDMRELPPWMYGLRNLEELY--- 520 Query: 428 NNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALD 487 + +SH +I +V +E L L Sbjct: 521 -----LVGSLSH-----------DISRNVTLE----------------------SLRDLK 542 Query: 488 SLYYLSVNGNYISEIP---VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQ 544 SL LS+ N +S+IP VD+S Q + + KL++ + + + NL L+L Sbjct: 543 SLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLN-NLKKMTNLTELELVHCD 600 Query: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC--NLK 602 +++IP ++ +++SL Q LDL EN L+ I + +L+ Sbjct: 601 LERIPHAVFSLLSL-----------------------QELDLKENNLKSIEEIVSFQHLR 637 Query: 603 GIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNA 662 + L N + P + +L SLE+L+ S K+ LP L +++ LD+S N Sbjct: 638 KLTVLKLWHNSITYIPEHIKKLTSLERLSFSH---NKIEVLPSHLFLCNKIRYLDLSYND 694 Query: 663 IREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSL 722 IR IP IG L++L N++ LP L L+ L + N+L+ L I N+ L Sbjct: 695 IRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 754 Query: 723 KEINFDDN--PLLRPPVEICK 741 ++ N +L P + C+ Sbjct: 755 SYLDVKGNHFEILPPELGDCR 775 Score = 87.4 bits (215), Expect = 5e-17 Identities = 74/318 (23%), Positives = 154/318 (48%), Gaps = 8/318 (2%) Query: 157 PKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRIL 216 P I ++ ++ L L + +K A S L++LS++ + + LP + L NL L Sbjct: 460 PATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEEL 519 Query: 217 ----NVSHNHISHIPKE-ISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271 ++SH+ ++ E + L +++ L +N + + ++ +L+ + + + + Sbjct: 520 YLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKL 579 Query: 272 IP-DTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPK--EIRELKNL 328 + + L + L L L + L P A+ L L LDL N + S+ + + L+ L Sbjct: 580 VMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKL 639 Query: 329 ETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIP 388 L + HN +T++ I +L ++ L + NK+EV+ + ++R L L N ++ IP Sbjct: 640 TVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIP 699 Query: 389 EKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEF 448 +I L+ S++ NK+ LP ++ L+ L + +N++ ++ I +L + L+ Sbjct: 700 PEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDV 759 Query: 449 SGNIITDVPIEIKNCQKI 466 GN +P E+ +C+ + Sbjct: 760 KGNHFEILPPELGDCRAL 777 Score = 84.0 bits (206), Expect = 6e-16 Identities = 59/209 (28%), Positives = 102/209 (48%), Gaps = 27/209 (12%) Query: 187 LLGLEILSLQENGLSSLPSEIQLLH--NLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244 LL L+ L L+EN L S+ + H L +L + HN I++IP+ I +L ++ +L F +N Sbjct: 611 LLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHN 670 Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304 IE PS L + L L N +R IP + L++L+ + Sbjct: 671 KIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS------------------ 712 Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI 364 +T N + SLP E+ K L+TL + N L+ L+ +I LL + L + N E++ Sbjct: 713 -----ITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEIL 767 Query: 365 SHKIENFRELRI--LILDKNLLKNIPEKI 391 ++ + R L+ L+++ L + +P + Sbjct: 768 PPELGDCRALKRAGLVVEDALFETLPSDV 796 Score = 80.9 bits (198), Expect = 5e-15 Identities = 84/358 (23%), Positives = 155/358 (43%), Gaps = 38/358 (10%) Query: 402 LSDNKLTELPKYIHKLNN-------LRKLHVNRNNMVKIT--------DCISHLNNICSL 446 +S+NKL +L LNN +KL N +N +++ D + + + SL Sbjct: 395 VSENKLKQL-----NLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSL 449 Query: 447 EFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL-DSLYYLSVNGNYISEIPVD 505 + +P I + ++ L + L L ++L LSV + + E+P Sbjct: 450 KLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPW 509 Query: 506 ISFSKQLLHL--------ELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557 + + L L ++S N L E L +LK L + K+ + KIP ++ + +S Sbjct: 510 MYGLRNLEELYLVGSLSHDISRNVTL---ESLRDLKSLKILSI-KSNVSKIPQAVVD-VS 564 Query: 558 LHVLILCCNKFET---FPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQF 614 H+ +C + T L + NL L+L L++I + +L +Q+L+ N Sbjct: 565 SHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL 624 Query: 615 IHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELR 674 E+ Q L +L + ++ +T +P + +T L+ L S+N I +P ++ Sbjct: 625 KSIE-EIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCN 683 Query: 675 NLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPL 732 + L N I ++PP + L LQ +++ N + +LP +Y LK + N L Sbjct: 684 KIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741 >gi|197333692 leucine rich repeat containing 8 family, member B [Homo sapiens] Length = 803 Score = 115 bits (287), Expect = 2e-25 Identities = 113/396 (28%), Positives = 191/396 (48%), Gaps = 40/396 (10%) Query: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQL-FFYNNYIENFPSDLECLGN 258 L+ LP + L + +L++ +P +SQL N+++L ++++ + + P+ N Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488 Query: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNLEY----NQLTTFP-KALCFLPKLISLDLTGN 313 L+IL L ++ IP + LK L+ L L QL+T + L L +L L + Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548 Query: 314 LISSLPKEIREL-KNLETLLMDH--NKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN 370 L S +P+ + +L +L+ L +D+ +KL L + +++ +K L+L LE I H I + Sbjct: 549 L-SRIPQVVTDLLPSLQKLSLDNEGSKLVVLN-NLKKMVNLKSLELISCDLERIPHSIFS 606 Query: 371 FRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428 L L L +N LK + E IS + L CL L N + +P I L+NL +L ++ N Sbjct: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666 Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488 N I ++P+++ C K+ ++LSYN + + P + L + Sbjct: 667 N-----------------------IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSN 703 Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548 L Y +V N I +P + K+L L L +N L+ S H L NL +L+L N ++ + Sbjct: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763 Query: 549 PASISNMISL--HVLILCCNKFETFPRELCTLENLQ 582 P + SL + LI+ N T P L E LQ Sbjct: 764 PPELEGCQSLKRNCLIVEENLLNTLP--LPVTERLQ 797 Score = 97.8 bits (242), Expect = 4e-20 Identities = 67/216 (31%), Positives = 111/216 (51%), Gaps = 8/216 (3%) Query: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEIS--QLGNIRQLFFYNN 244 ++ L+ L L L +P I L+NL L++ N++ + + IS L N+ L ++N Sbjct: 584 MVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHN 643 Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304 I P+ + L NLE LSL N + ++P L L L+L YN LT P+ + +L Sbjct: 644 NIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSN 703 Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI 364 L +T N I LP + + K L+ LL+ N L L+ + +L + L+L N LE + Sbjct: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763 Query: 365 SHKIENFRELR--ILILDKNLLKNIP----EKISCC 394 ++E + L+ LI+++NLL +P E++ C Sbjct: 764 PPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTC 799 Score = 96.3 bits (238), Expect = 1e-19 Identities = 81/298 (27%), Positives = 134/298 (44%), Gaps = 32/298 (10%) Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLD----KNQIKTFQGADSGDLLGLEIL-------- 193 + L+ + + P+ + +K +K LYL Q+ T Q DL L L Sbjct: 492 LRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSR 551 Query: 194 ----------SLQENGLSSLPSEIQLLHNLR------ILNVSHNHISHIPKEISQLGNIR 237 SLQ+ L + S++ +L+NL+ L + + IP I L N+ Sbjct: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611 Query: 238 QLFFYNNYIENFPS--DLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTF 295 +L N ++ + L NL L L N + +IP + +L L L+L++N + Sbjct: 612 ELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENL 671 Query: 296 PKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQ 355 P L KL LDL+ N ++ +P+EI+ L NL+ + +N + L +FQ K++ L Sbjct: 672 PLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731 Query: 356 LADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLE--CLSLSDNKLTELP 411 L N L +S + L L L N L+ +P ++ C L+ CL + +N L LP Sbjct: 732 LGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789 Score = 95.5 bits (236), Expect = 2e-19 Identities = 100/399 (25%), Positives = 179/399 (44%), Gaps = 75/399 (18%) Query: 128 QVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGD- 186 +VSE KQ+ L E+ + LK K VK DK ++ F D Sbjct: 390 EVSENKLKQINLN-------------NEWTVEKLKSKLVKNAQ-DKIELHLFMLNGLPDN 435 Query: 187 ---LLGLEILSLQENGLSSLPS---------EIQLLH---------------NLRILNVS 219 L +E+LSL+ LPS E+++ H NL+IL + Sbjct: 436 VFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLK 495 Query: 220 HNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-----NLEILSLGKNKLRHIP- 273 + IP+ + L N+++L+ + S ++ G NL L L K+ L IP Sbjct: 496 FTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYL-KSSLSRIPQ 554 Query: 274 ---DTLPSLKTL----------------RVLNLEYNQLTT-----FPKALCFLPKLISLD 309 D LPSL+ L +++NL+ +L + P ++ L L LD Sbjct: 555 VVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELD 614 Query: 310 LTGNLISSLPKEI--RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367 L N + ++ + I + L+NL L + HN + ++ +I L +++L L N +E + + Sbjct: 615 LRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQ 674 Query: 368 IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNR 427 + +L L L N L IPE+I + L+ ++++N + LP + + L+ L + + Sbjct: 675 LFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGK 734 Query: 428 NNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466 N+++ ++ + L+N+ LE GN + +P E++ CQ + Sbjct: 735 NSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773 Score = 84.7 bits (208), Expect = 3e-16 Identities = 103/376 (27%), Positives = 165/376 (43%), Gaps = 43/376 (11%) Query: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373 +++ LP + EL +E L ++ L + QL+ +KEL++ + L V+ H F E Sbjct: 428 MLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSL-VVDHPALAFLE 486 Query: 374 --LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIH-----KLNNLRKLHVN 426 L+IL L + IP + L+ L LS L E + L NLR L++ Sbjct: 487 ENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYL- 545 Query: 427 RNNMVKI----TDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLG 482 ++++ +I TD + L + SL+ G+ + + + N +K++ ++ Sbjct: 546 KSSLSRIPQVVTDLLPSLQKL-SLDNEGSKL----VVLNNLKKMVNLK------------ 588 Query: 483 LCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDL 540 SL +S + + IP I L L+L EN L E F L NL L L Sbjct: 589 -----SLELISCD---LERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKL 640 Query: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600 N I IPA I + +L L L N E P +L L LDLS N L I +I Sbjct: 641 WHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQY 700 Query: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660 L +Q ++N P L Q + L+ L + + L+ GELSN+T L++ Sbjct: 701 LSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLT---HLELIG 757 Query: 661 NAIREIPRNIGELRNL 676 N + +P + ++L Sbjct: 758 NYLETLPPELEGCQSL 773 Score = 79.7 bits (195), Expect = 1e-14 Identities = 56/153 (36%), Positives = 78/153 (50%), Gaps = 4/153 (2%) Query: 182 ADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFF 241 A G L LE LSL N + +LP ++ L L L++S+NH++ IP+EI L N++ Sbjct: 650 AQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAV 709 Query: 242 YNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL-- 299 NN IE P L L+ L LGKN L ++ + L L L L N L T P L Sbjct: 710 TNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEG 769 Query: 300 CFLPKLISLDLTGNLISSLPKEIRELKNLETLL 332 C K L + NL+++LP + E L+T L Sbjct: 770 CQSLKRNCLIVEENLLNTLPLPVTE--RLQTCL 800 Score = 79.0 bits (193), Expect = 2e-14 Identities = 97/431 (22%), Positives = 188/431 (43%), Gaps = 41/431 (9%) Query: 355 QLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYI 414 ++++NKL+ I+ E + L L+KN +KI + L LP + Sbjct: 390 EVSENKLKQINLN----NEWTVEKLKSKLVKNAQDKIELHLFM---------LNGLPDNV 436 Query: 415 HKLNNLRKLHVNRNNMVKITDCISHLNNICSLE-FSGNIITDVPIEIKNCQKIIKIELSY 473 +L + L + VK+ +S L N+ L + +++ D P + + + L + Sbjct: 437 FELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKF 496 Query: 474 NKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLI 533 ++ P + L +L L ++G + E QL ++L E F L Sbjct: 497 TEMGKIPRWVFHLKNLKELYLSGCVLPE---------QLSTMQL---------EGFQDLK 538 Query: 534 NLKYLDLGKNQIKKIPASISNMI-SLHVLILCCNKFETFP-RELCTLENLQVLDLSENQL 591 NL+ L L K+ + +IP +++++ SL L L + L + NL+ L+L L Sbjct: 539 NLRTLYL-KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDL 597 Query: 592 QKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMT 651 ++I I +L + +L+ N + E+ Q L+ L+ ++ + +P ++ ++ Sbjct: 598 ERIPHSIFSLNNLHELDLRENN-LKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALS 656 Query: 652 QLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTA 711 L++L + +N I +P + L L N ++++P + L++LQ ++ NN+ Sbjct: 657 NLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEM 716 Query: 712 LPSAIYNIFSLKEINFDDNPL--LRPPV-EICKGKQLYTIARYLQRADERDE--KILEKI 766 LP ++ L+ + N L L P V E+ L I YL+ E + L++ Sbjct: 717 LPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776 Query: 767 FKIVANNITET 777 IV N+ T Sbjct: 777 CLIVEENLLNT 787 >gi|21245134 leucine rich repeat containing 8 family, member B [Homo sapiens] Length = 803 Score = 115 bits (287), Expect = 2e-25 Identities = 113/396 (28%), Positives = 191/396 (48%), Gaps = 40/396 (10%) Query: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQL-FFYNNYIENFPSDLECLGN 258 L+ LP + L + +L++ +P +SQL N+++L ++++ + + P+ N Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488 Query: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNLEY----NQLTTFP-KALCFLPKLISLDLTGN 313 L+IL L ++ IP + LK L+ L L QL+T + L L +L L + Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548 Query: 314 LISSLPKEIREL-KNLETLLMDH--NKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN 370 L S +P+ + +L +L+ L +D+ +KL L + +++ +K L+L LE I H I + Sbjct: 549 L-SRIPQVVTDLLPSLQKLSLDNEGSKLVVLN-NLKKMVNLKSLELISCDLERIPHSIFS 606 Query: 371 FRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428 L L L +N LK + E IS + L CL L N + +P I L+NL +L ++ N Sbjct: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666 Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488 N I ++P+++ C K+ ++LSYN + + P + L + Sbjct: 667 N-----------------------IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSN 703 Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548 L Y +V N I +P + K+L L L +N L+ S H L NL +L+L N ++ + Sbjct: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763 Query: 549 PASISNMISL--HVLILCCNKFETFPRELCTLENLQ 582 P + SL + LI+ N T P L E LQ Sbjct: 764 PPELEGCQSLKRNCLIVEENLLNTLP--LPVTERLQ 797 Score = 97.8 bits (242), Expect = 4e-20 Identities = 67/216 (31%), Positives = 111/216 (51%), Gaps = 8/216 (3%) Query: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEIS--QLGNIRQLFFYNN 244 ++ L+ L L L +P I L+NL L++ N++ + + IS L N+ L ++N Sbjct: 584 MVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHN 643 Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304 I P+ + L NLE LSL N + ++P L L L+L YN LT P+ + +L Sbjct: 644 NIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSN 703 Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI 364 L +T N I LP + + K L+ LL+ N L L+ + +L + L+L N LE + Sbjct: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763 Query: 365 SHKIENFRELR--ILILDKNLLKNIP----EKISCC 394 ++E + L+ LI+++NLL +P E++ C Sbjct: 764 PPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTC 799 Score = 96.3 bits (238), Expect = 1e-19 Identities = 81/298 (27%), Positives = 134/298 (44%), Gaps = 32/298 (10%) Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLD----KNQIKTFQGADSGDLLGLEIL-------- 193 + L+ + + P+ + +K +K LYL Q+ T Q DL L L Sbjct: 492 LRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSR 551 Query: 194 ----------SLQENGLSSLPSEIQLLHNLR------ILNVSHNHISHIPKEISQLGNIR 237 SLQ+ L + S++ +L+NL+ L + + IP I L N+ Sbjct: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611 Query: 238 QLFFYNNYIENFPS--DLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTF 295 +L N ++ + L NL L L N + +IP + +L L L+L++N + Sbjct: 612 ELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENL 671 Query: 296 PKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQ 355 P L KL LDL+ N ++ +P+EI+ L NL+ + +N + L +FQ K++ L Sbjct: 672 PLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731 Query: 356 LADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLE--CLSLSDNKLTELP 411 L N L +S + L L L N L+ +P ++ C L+ CL + +N L LP Sbjct: 732 LGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789 Score = 95.5 bits (236), Expect = 2e-19 Identities = 100/399 (25%), Positives = 179/399 (44%), Gaps = 75/399 (18%) Query: 128 QVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGD- 186 +VSE KQ+ L E+ + LK K VK DK ++ F D Sbjct: 390 EVSENKLKQINLN-------------NEWTVEKLKSKLVKNAQ-DKIELHLFMLNGLPDN 435 Query: 187 ---LLGLEILSLQENGLSSLPS---------EIQLLH---------------NLRILNVS 219 L +E+LSL+ LPS E+++ H NL+IL + Sbjct: 436 VFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLK 495 Query: 220 HNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-----NLEILSLGKNKLRHIP- 273 + IP+ + L N+++L+ + S ++ G NL L L K+ L IP Sbjct: 496 FTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYL-KSSLSRIPQ 554 Query: 274 ---DTLPSLKTL----------------RVLNLEYNQLTT-----FPKALCFLPKLISLD 309 D LPSL+ L +++NL+ +L + P ++ L L LD Sbjct: 555 VVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELD 614 Query: 310 LTGNLISSLPKEI--RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367 L N + ++ + I + L+NL L + HN + ++ +I L +++L L N +E + + Sbjct: 615 LRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQ 674 Query: 368 IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNR 427 + +L L L N L IPE+I + L+ ++++N + LP + + L+ L + + Sbjct: 675 LFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGK 734 Query: 428 NNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466 N+++ ++ + L+N+ LE GN + +P E++ CQ + Sbjct: 735 NSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773 Score = 84.7 bits (208), Expect = 3e-16 Identities = 103/376 (27%), Positives = 165/376 (43%), Gaps = 43/376 (11%) Query: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373 +++ LP + EL +E L ++ L + QL+ +KEL++ + L V+ H F E Sbjct: 428 MLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSL-VVDHPALAFLE 486 Query: 374 --LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIH-----KLNNLRKLHVN 426 L+IL L + IP + L+ L LS L E + L NLR L++ Sbjct: 487 ENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYL- 545 Query: 427 RNNMVKI----TDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLG 482 ++++ +I TD + L + SL+ G+ + + + N +K++ ++ Sbjct: 546 KSSLSRIPQVVTDLLPSLQKL-SLDNEGSKL----VVLNNLKKMVNLK------------ 588 Query: 483 LCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDL 540 SL +S + + IP I L L+L EN L E F L NL L L Sbjct: 589 -----SLELISCD---LERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKL 640 Query: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600 N I IPA I + +L L L N E P +L L LDLS N L I +I Sbjct: 641 WHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQY 700 Query: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660 L +Q ++N P L Q + L+ L + + L+ GELSN+T L++ Sbjct: 701 LSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLT---HLELIG 757 Query: 661 NAIREIPRNIGELRNL 676 N + +P + ++L Sbjct: 758 NYLETLPPELEGCQSL 773 Score = 79.7 bits (195), Expect = 1e-14 Identities = 56/153 (36%), Positives = 78/153 (50%), Gaps = 4/153 (2%) Query: 182 ADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFF 241 A G L LE LSL N + +LP ++ L L L++S+NH++ IP+EI L N++ Sbjct: 650 AQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAV 709 Query: 242 YNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL-- 299 NN IE P L L+ L LGKN L ++ + L L L L N L T P L Sbjct: 710 TNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEG 769 Query: 300 CFLPKLISLDLTGNLISSLPKEIRELKNLETLL 332 C K L + NL+++LP + E L+T L Sbjct: 770 CQSLKRNCLIVEENLLNTLPLPVTE--RLQTCL 800 Score = 79.0 bits (193), Expect = 2e-14 Identities = 97/431 (22%), Positives = 188/431 (43%), Gaps = 41/431 (9%) Query: 355 QLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYI 414 ++++NKL+ I+ E + L L+KN +KI + L LP + Sbjct: 390 EVSENKLKQINLN----NEWTVEKLKSKLVKNAQDKIELHLFM---------LNGLPDNV 436 Query: 415 HKLNNLRKLHVNRNNMVKITDCISHLNNICSLE-FSGNIITDVPIEIKNCQKIIKIELSY 473 +L + L + VK+ +S L N+ L + +++ D P + + + L + Sbjct: 437 FELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKF 496 Query: 474 NKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLI 533 ++ P + L +L L ++G + E QL ++L E F L Sbjct: 497 TEMGKIPRWVFHLKNLKELYLSGCVLPE---------QLSTMQL---------EGFQDLK 538 Query: 534 NLKYLDLGKNQIKKIPASISNMI-SLHVLILCCNKFETFP-RELCTLENLQVLDLSENQL 591 NL+ L L K+ + +IP +++++ SL L L + L + NL+ L+L L Sbjct: 539 NLRTLYL-KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDL 597 Query: 592 QKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMT 651 ++I I +L + +L+ N + E+ Q L+ L+ ++ + +P ++ ++ Sbjct: 598 ERIPHSIFSLNNLHELDLRENN-LKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALS 656 Query: 652 QLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTA 711 L++L + +N I +P + L L N ++++P + L++LQ ++ NN+ Sbjct: 657 NLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEM 716 Query: 712 LPSAIYNIFSLKEINFDDNPL--LRPPV-EICKGKQLYTIARYLQRADERDE--KILEKI 766 LP ++ L+ + N L L P V E+ L I YL+ E + L++ Sbjct: 717 LPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776 Query: 767 FKIVANNITET 777 IV N+ T Sbjct: 777 CLIVEENLLNT 787 >gi|4504379 leucine-rich repeat-containing G protein-coupled receptor 5 [Homo sapiens] Length = 907 Score = 112 bits (279), Expect = 2e-24 Identities = 112/395 (28%), Positives = 201/395 (50%), Gaps = 22/395 (5%) Query: 154 QEFPKDILKIKYVKYLYLDKNQIKTF-QGADSGDLLGLEILSLQENGLSSLPSE-IQLLH 211 Q P + +++++ L L N + +GA +G L L++L LQ N L +P+E +Q L Sbjct: 80 QLLPNPLPSLRFLEELRLAGNALTYIPKGAFTG-LYSLKVLMLQNNQLRHVPTEALQNLR 138 Query: 212 NLRILNVSHNHISHIPKE-ISQLGNIRQLFFYNNYIENFP-SDLECLGNLEILSLGKNKL 269 +L+ L + NHIS++P S L ++R L+ +N + P L L+ ++L NK+ Sbjct: 139 SLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKI 198 Query: 270 RHIPD-TLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTGNLISSLPKEIRELK 326 HIPD +L +L VL+L N++ + K CF L L +LDL N + P IR L Sbjct: 199 HHIPDYAFGNLSSLVVLHLHNNRIHSLGKK-CFDGLHSLETLDLNYNNLDEFPTAIRTLS 257 Query: 327 NLETLLMDHNKLTFLAVEIF-QLLKIKELQLADNKLEVISHK-IENFRELRILILD-KNL 383 NL+ L N + + + F + + DN ++ + ++ ELR L L+ + Sbjct: 258 NLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQ 317 Query: 384 LKNIPEKISCCAMLECLSLSDNKLTELPKYI-HKLNNLRKLHVNRNNMVKITDCISHLNN 442 + P+ ++ A LE L+L+ +++ LP+ + ++L NL+ L ++ N+++ S Sbjct: 318 ITEFPD-LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLS-YNLLEDLPSFSVCQK 375 Query: 443 ICSLEFSGNIITDVPIE-IKNCQKIIKIELSYNKI-MYFPLGLCALDSLYYLSVNGNYIS 500 + ++ N I ++ ++ + + + L++NKI + P L SL L ++ N +S Sbjct: 376 LQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435 Query: 501 EIPVDISFSKQLLHLELSEN---KLLIFSEHFCSL 532 P I+ L HL+L+ N + LI SE+F L Sbjct: 436 SFP--ITGLHGLTHLKLTGNHALQSLISSENFPEL 468 Score = 107 bits (266), Expect = 6e-23 Identities = 121/415 (29%), Positives = 195/415 (46%), Gaps = 33/415 (7%) Query: 308 LDLTGNLISSL-PKEIRELKNLETLLMDHNKLTFLAVEIFQ-LLKIKELQLADNKLE-VI 364 LDL+ N IS L P + L+ LE L + N LT++ F L +K L L +N+L V Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130 Query: 365 SHKIENFRELRILILDKNLLKNIPEKISCCAMLECLS---LSDNKLTELP-KYIHKLNNL 420 + ++N R L+ L LD N + +P SC + L L L DN LTE+P + L+ L Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPP--SCFSGLHSLRHLWLDDNALTEIPVQAFRSLSAL 188 Query: 421 RKLHVNRNNMVKITD-CISHLNNICSLEFSGNIITDVPIEIKNC----QKIIKIELSYNK 475 + + + N + I D +L+++ L N I + K C + ++L+YN Sbjct: 189 QAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLG---KKCFDGLHSLETLDLNYNN 245 Query: 476 IMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSK-QLLHLELSENKL-LIFSEHFCSLI 533 + FP + L +L L + N I IP L+ + +N + + F L Sbjct: 246 LDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLP 305 Query: 534 NLKYLDL-GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCT-LENLQVLDLSENQL 591 L+ L L G +QI + P ++ +L L L + + P+ +C L NLQVLDLS N L Sbjct: 306 ELRTLTLNGASQITEFP-DLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 364 Query: 592 QKISS-DICNLKGIQKLNFSSNQFIHFPIELCQ-LQSLEQLNISQIKGRKLTRLPGELSN 649 + + S +C + +QK++ N+ ++ Q L SL LN++ K + P S Sbjct: 365 EDLPSFSVC--QKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIH--PNAFST 420 Query: 650 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNL 704 + L +LD+S+N + P I L L L N + SL+S + +L + Sbjct: 421 LPSLIKLDLSSNLLSSFP--ITGLHGLTHLKLTGN---HALQSLISSENFPELKV 470 Score = 101 bits (252), Expect = 3e-21 Identities = 126/402 (31%), Positives = 189/402 (47%), Gaps = 17/402 (4%) Query: 223 ISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD-TLPSLKT 281 +S +P +S + L NN + P+ L L LE L L N L +IP L + Sbjct: 57 LSELPSNLSVFTSYLDLSM-NNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYS 115 Query: 282 LRVLNLEYNQLTTFP-KALCFLPKLISLDLTGNLISSLPKE-IRELKNLETLLMDHNKLT 339 L+VL L+ NQL P +AL L L SL L N IS +P L +L L +D N LT Sbjct: 116 LKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALT 175 Query: 340 FLAVEIFQLLK-IKELQLADNKLEVI-SHKIENFRELRILILDKNLLKNIPEK-ISCCAM 396 + V+ F+ L ++ + LA NK+ I + N L +L L N + ++ +K Sbjct: 176 EIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHS 235 Query: 397 LECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLN-NICSLEFSGNIITD 455 LE L L+ N L E P I L+NL++L + NN+ I + N ++ ++ F N I Sbjct: 236 LETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQF 295 Query: 456 V-PIEIKNCQKIIKIELS-YNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDI-SFSKQL 512 V ++ ++ + L+ ++I FP L +L L++ G IS +P + + L Sbjct: 296 VGRSAFQHLPELRTLTLNGASQITEFP-DLTGTANLESLTLTGAQISSLPQTVCNQLPNL 354 Query: 513 LHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPA-SISNMISLHVLILCCNKFETF 571 L+LS N LL F L+ +DL N+I +I + ++SL L L NK Sbjct: 355 QVLDLSYN-LLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII 413 Query: 572 -PRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSN 612 P TL +L LDLS N L S I L G+ L + N Sbjct: 414 HPNAFSTLPSLIKLDLSSNLLS--SFPITGLHGLTHLKLTGN 453 Score = 79.0 bits (193), Expect = 2e-14 Identities = 68/222 (30%), Positives = 108/222 (48%), Gaps = 9/222 (4%) Query: 537 YLDLGKNQIKKI-PASISNMISLHVLILCCNKFETFPRELCT-LENLQVLDLSENQLQKI 594 YLDL N I ++ P + ++ L L L N P+ T L +L+VL L NQL+ + Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129 Query: 595 SSD-ICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE-LSNMTQ 652 ++ + NL+ +Q L +N + P L L + LT +P + +++ Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSC--FSGLHSLRHLWLDDNALTEIPVQAFRSLSA 187 Query: 653 LKELDISNNAIREIPRN-IGELRNLVSLHAYNNQISYLPPSLLS-LNDLQQLNLSGNNLT 710 L+ + ++ N I IP G L +LV LH +NN+I L L+ L+ L+L+ NNL Sbjct: 188 LQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLD 247 Query: 711 ALPSAIYNIFSLKEINFDDNPLLRPPVEICKGK-QLYTIARY 751 P+AI + +LKE+ F N + P + G L TI Y Sbjct: 248 EFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFY 289 Score = 64.7 bits (156), Expect = 4e-10 Identities = 88/331 (26%), Positives = 147/331 (44%), Gaps = 48/331 (14%) Query: 469 IELSYNKI-MYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLL--IF 525 ++LS N I P L +L L L + GN ++ IP L + + +N L + Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130 Query: 526 SEHFCSLINLKYLDLGKNQIKKIPAS-ISNMISLHVLILCCNKFETFP-RELCTLENLQV 583 +E +L +L+ L L N I +P S S + SL L L N P + +L LQ Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190 Query: 584 LDLSENQLQKISS-DICNLKGIQKLNFSSNQFIHFPIELC--QLQSLEQLNISQIKGRKL 640 + L+ N++ I NL + L+ +N+ IH + C L SLE L+++ L Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNR-IHSLGKKCFDGLHSLETLDLNY---NNL 246 Query: 641 TRLPGELSNMTQLKELDISNNAIREIPRN--IGELRNLVSLHAYNNQISY--------LP 690 P + ++ LKEL +N IR IP +G +L+++H Y+N I + LP Sbjct: 247 DEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGN-PSLITIHFYDNPIQFVGRSAFQHLP 305 Query: 691 ----------------PSLLSLNDLQQLNLSGNNLTALPSAIYN-IFSLKEINFDDNPLL 733 P L +L+ L L+G +++LP + N + +L+ ++ N L Sbjct: 306 ELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLE 365 Query: 734 RPPVEICKGKQLYTIARYLQRADERDEKILE 764 P +++ + LQ+ D R +I E Sbjct: 366 DLP--------SFSVCQKLQKIDLRHNEIYE 388 >gi|193788651 leucine rich repeat containing 69 [Homo sapiens] Length = 347 Score = 112 bits (279), Expect = 2e-24 Identities = 63/204 (30%), Positives = 110/204 (53%), Gaps = 1/204 (0%) Query: 400 LSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIE 459 ++L+ K+T++P + KL L+ L + N + K+ + +L + +L N++ +VP E Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78 Query: 460 IKNCQKIIKIELSYNKIMYFPLGLC-ALDSLYYLSVNGNYISEIPVDISFSKQLLHLELS 518 +K + + LS N+I F G C L +L L++N N+++++P ++S K L ++ ++ Sbjct: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138 Query: 519 ENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTL 578 N+L C L NL L L NQ+ IP I + L L+L N P ELC L Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198 Query: 579 ENLQVLDLSENQLQKISSDICNLK 602 + L++LD++ N +Q S +LK Sbjct: 199 KKLRILDIAGNIIQIFPSGFQDLK 222 Score = 110 bits (274), Expect = 7e-24 Identities = 64/193 (33%), Positives = 107/193 (55%), Gaps = 4/193 (2%) Query: 185 GDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244 G L GL+ L LQ N + + E+ L L LN+ +N + +P+E+ L +++ L N Sbjct: 34 GKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGN 93 Query: 245 YIENF-PSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLP 303 I F P + L NL +L+L N L +P + LK+L +++ YNQL + P+ LCFL Sbjct: 94 RICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLE 153 Query: 304 KLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEV 363 L+ L L N + +P+EI+ LK L+ LL+ N + L E+ L K++ L +A N +++ Sbjct: 154 NLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQI 213 Query: 364 ISHKIENFRELRI 376 F++L++ Sbjct: 214 FP---SGFQDLKL 223 Score = 99.0 bits (245), Expect = 2e-20 Identities = 67/254 (26%), Positives = 116/254 (45%), Gaps = 11/254 (4%) Query: 534 NLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQK 593 N K + L ++ K+P+++ + L L+L N ELC L L L+L N L++ Sbjct: 15 NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74 Query: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQL 653 + ++ L ++ L+ S N+ F C L+ L + + LT+LP E+S + L Sbjct: 75 VPEEMKYLTSLKNLHLSGNRICRFAPGACD--GLQNLILLNLNNNHLTQLPQEVSRLKSL 132 Query: 654 KELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALP 713 + I+ N + IPR + L NLV L NQ+ +P + L LQ+L L+ NN+ LP Sbjct: 133 TYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLP 192 Query: 714 SAIYNIFSLKEINFDDNPL---------LRPPVEICKGKQLYTIARYLQRADERDEKILE 764 + ++ L+ ++ N + L+ C+G L+ + E + E Sbjct: 193 EELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENVWSLQE 252 Query: 765 KIFKIVANNITETN 778 + V N + E N Sbjct: 253 ITSRFVMNQLAENN 266 Score = 95.9 bits (237), Expect = 1e-19 Identities = 59/199 (29%), Positives = 111/199 (55%), Gaps = 1/199 (0%) Query: 191 EILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP 250 +I++L ++ +PS + L L+ L + +N I + E+ L + L NN +E P Sbjct: 17 KIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVP 76 Query: 251 SDLECLGNLEILSLGKNKL-RHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLD 309 +++ L +L+ L L N++ R P L+ L +LNL N LT P+ + L L + Sbjct: 77 EEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMS 136 Query: 310 LTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIE 369 + N ++S+P+E+ L+NL L +++N+L + EI L K+++L LA N + V+ ++ Sbjct: 137 INYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELC 196 Query: 370 NFRELRILILDKNLLKNIP 388 + ++LRIL + N+++ P Sbjct: 197 DLKKLRILDIAGNIIQIFP 215 Score = 94.4 bits (233), Expect = 4e-19 Identities = 67/238 (28%), Positives = 122/238 (51%), Gaps = 3/238 (1%) Query: 212 NLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271 N +I+ ++ ++ +P + +L ++ L NN I +L L L L+LG N L Sbjct: 15 NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74 Query: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCF-LPKLISLDLTGNLISSLPKEIRELKNLET 330 +P+ + L +L+ L+L N++ F C L LI L+L N ++ LP+E+ LK+L Sbjct: 75 VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134 Query: 331 LLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEK 390 + +++N+L + E+ L + ELQL N+L I +I+ ++L+ L+L +N + +PE+ Sbjct: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194 Query: 391 ISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCIS-HLNNICSLE 447 + L L ++ N + P L LR+ + N + IS N+ SL+ Sbjct: 195 LCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVISTQQENVWSLQ 251 Score = 94.4 bits (233), Expect = 4e-19 Identities = 62/189 (32%), Positives = 97/189 (51%), Gaps = 1/189 (0%) Query: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505 + +G +T +P + + + L N I LC L L L++ N + E+P + Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78 Query: 506 ISFSKQLLHLELSENKLLIFSEHFCS-LINLKYLDLGKNQIKKIPASISNMISLHVLILC 564 + + L +L LS N++ F+ C L NL L+L N + ++P +S + SL + + Sbjct: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138 Query: 565 CNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQL 624 N+ + PRELC LENL L L+ NQL I +I LK +QKL + N P ELC L Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198 Query: 625 QSLEQLNIS 633 + L L+I+ Sbjct: 199 KKLRILDIA 207 Score = 87.0 bits (214), Expect = 7e-17 Identities = 59/204 (28%), Positives = 106/204 (51%), Gaps = 1/204 (0%) Query: 280 KTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLT 339 K +++ L ++T P AL LP L +L L NLI + E+ L L TL + +N L Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73 Query: 340 FLAVEIFQLLKIKELQLADNKL-EVISHKIENFRELRILILDKNLLKNIPEKISCCAMLE 398 + E+ L +K L L+ N++ + + L +L L+ N L +P+++S L Sbjct: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133 Query: 399 CLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPI 458 +S++ N+L +P+ + L NL +L +N N ++ I + I L + L + N I +P Sbjct: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193 Query: 459 EIKNCQKIIKIELSYNKIMYFPLG 482 E+ + +K+ ++++ N I FP G Sbjct: 194 ELCDLKKLRILDIAGNIIQIFPSG 217 Score = 84.7 bits (208), Expect = 3e-16 Identities = 69/244 (28%), Positives = 114/244 (46%), Gaps = 34/244 (13%) Query: 145 TVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLP 204 T+NL L+E P+++ + +K L+L N+I F L L +L+L N L+ LP Sbjct: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123 Query: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264 E+ L +L +++++N ++ IP R+L F N +E L L Sbjct: 124 QEVSRLKSLTYMSINYNQLASIP---------RELCFLENLVE--------------LQL 160 Query: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRE 324 N+L IP+ + LK L+ L L N + P+ LC L KL LD+ GN+I P ++ Sbjct: 161 NYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQD 220 Query: 325 LKNLE------TLLMDHNKLTFLAVEIFQLLKIKEL----QLADNKLEVISHKIENFREL 374 LK E L + ++ ++ L +I QLA+N + IE + ++ Sbjct: 221 LKLREFYCEGNPLFLQQPVISTQQENVWSLQEITSRFVMNQLAENN-PFLMDDIERYPQV 279 Query: 375 RILI 378 R +I Sbjct: 280 RSMI 283 Score = 71.2 bits (173), Expect = 4e-12 Identities = 47/162 (29%), Positives = 82/162 (50%), Gaps = 4/162 (2%) Query: 579 ENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGR 638 +N +++ L+ ++ K+ S + L G++ L +N ELC L L LN+ Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLG---NN 70 Query: 639 KLTRLPGELSNMTQLKELDISNNAI-REIPRNIGELRNLVSLHAYNNQISYLPPSLLSLN 697 L +P E+ +T LK L +S N I R P L+NL+ L+ NN ++ LP + L Sbjct: 71 LLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK 130 Query: 698 DLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739 L ++++ N L ++P + + +L E+ + N L+ P EI Sbjct: 131 SLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEI 172 Score = 67.8 bits (164), Expect = 4e-11 Identities = 61/202 (30%), Positives = 94/202 (46%), Gaps = 1/202 (0%) Query: 228 KEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNL 287 K +S N + + + PS L L L+ L L N + + L +L L LNL Sbjct: 8 KALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNL 67 Query: 288 EYNQLTTFPKALCFLPKLISLDLTGNLISSL-PKEIRELKNLETLLMDHNKLTFLAVEIF 346 N L P+ + +L L +L L+GN I P L+NL L +++N LT L E+ Sbjct: 68 GNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVS 127 Query: 347 QLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNK 406 +L + + + N+L I ++ L L L+ N L IPE+I L+ L L+ N Sbjct: 128 RLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNN 187 Query: 407 LTELPKYIHKLNNLRKLHVNRN 428 + LP+ + L LR L + N Sbjct: 188 IGVLPEELCDLKKLRILDIAGN 209 Score = 46.2 bits (108), Expect = 1e-04 Identities = 29/98 (29%), Positives = 46/98 (46%) Query: 647 LSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSG 706 LS K + ++ + ++P +G+L L +L NN I + P L +L L LNL Sbjct: 10 LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69 Query: 707 NNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQ 744 N L +P + + SLK ++ N + R C G Q Sbjct: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQ 107 >gi|14249428 leucine-rich repeats and calponin homology (CH) domain containing 3 [Homo sapiens] Length = 712 Score = 108 bits (270), Expect = 2e-23 Identities = 71/209 (33%), Positives = 104/209 (49%), Gaps = 8/209 (3%) Query: 538 LDLGKNQIKKIPASISN--MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKIS 595 L L ++++ P +N + L N+ P E C +L+ L+L +N ++ I Sbjct: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121 Query: 596 SDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKE 655 I NL+ + LN S NQ P+ LC L L + KL LP E+ ++ L E Sbjct: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLP----LKVLIASNNKLVSLPEEIGHLRHLME 177 Query: 656 LDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSA 715 LD+S N I+ IP IG L L L+ N + +LP L L L +L+ S N +T +P Sbjct: 178 LDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLDFSCNKITTIPVC 236 Query: 716 IYNIFSLKEINFDDNPLLRPPVEIC-KGK 743 N+ L+ I D+NPL PP +IC KGK Sbjct: 237 YRNLRHLQTITLDNNPLQSPPAQICIKGK 265 Score = 93.2 bits (230), Expect = 9e-19 Identities = 70/228 (30%), Positives = 114/228 (50%), Gaps = 9/228 (3%) Query: 469 IELSYNKIMYFPLGLCALD--SLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFS 526 + LS K+ FP G D ++ N +SEIP++ L +L L +N + Sbjct: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121 Query: 527 EHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDL 586 E +L L +L++ +NQ+ +P + N+ L VLI NK + P E+ L +L LD+ Sbjct: 122 EAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDV 180 Query: 587 SENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE 646 S N++Q I S I NL+ ++ LN N +H P EL +L L +L+ S K+T +P Sbjct: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLDFS---CNKITTIPVC 236 Query: 647 LSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY-NNQISYLPPSL 693 N+ L+ + + NN ++ P I ++ V + Y N Q + P L Sbjct: 237 YRNLRHLQTITLDNNPLQSPPAQIC-IKGKVHIFKYLNIQACKIAPDL 283 Score = 80.9 bits (198), Expect = 5e-15 Identities = 61/217 (28%), Positives = 104/217 (47%), Gaps = 4/217 (1%) Query: 270 RHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTGNLISSLPKEIRELKN 327 R + L VL+L +L FP+ L DL+ N +S +P E + Sbjct: 47 RSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVS 106 Query: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNI 387 LE L + N + ++ I L + L ++ N+L + + N L++LI N L ++ Sbjct: 107 LENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSL 165 Query: 388 PEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLE 447 PE+I L L +S N++ +P I L LR L+V RN++V + + ++ L + L+ Sbjct: 166 PEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLD 224 Query: 448 FSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLC 484 FS N IT +P+ +N + + I L N + P +C Sbjct: 225 FSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQIC 261 Score = 78.6 bits (192), Expect = 2e-14 Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 27/216 (12%) Query: 215 ILNVSHNHISHIPKEISQ--LGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHI 272 +L++S + P+ + L + + N + P + +LE L+L +N +R+I Sbjct: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120 Query: 273 PDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLL 332 P+ + +L+ L LN+ NQL+T P LC LP L+ L+ Sbjct: 121 PEAILNLQALTFLNISRNQLSTLPVHLCNLP------------------------LKVLI 156 Query: 333 MDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKIS 392 +NKL L EI L + EL ++ N+++ I +I N LR L + +N L ++PE+++ Sbjct: 157 ASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELA 216 Query: 393 CCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428 ++ L S NK+T +P L +L+ + ++ N Sbjct: 217 ELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNN 251 Score = 76.6 bits (187), Expect = 9e-14 Identities = 67/257 (26%), Positives = 116/257 (45%), Gaps = 30/257 (11%) Query: 385 KNIPEKISCCAMLECLSLSDNKLTELPKYI--HKLNNLRKLHVNRNNMVKITDCISHLNN 442 +++ + A+ LSLS KL E P+ H L + + ++RN + Sbjct: 47 RSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRL------------ 94 Query: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502 +++PIE + + + L N I Y P + L +L +L+++ N +S + Sbjct: 95 -----------SEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTL 143 Query: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562 PV + + L L S NKL+ E L +L LD+ N+I+ IP+ I N+ +L L Sbjct: 144 PVHLC-NLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLN 202 Query: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622 + N P EL L ++ LD S N++ I NL+ +Q + +N P ++C Sbjct: 203 VRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQIC 261 Query: 623 ---QLQSLEQLNISQIK 636 ++ + LNI K Sbjct: 262 IKGKVHIFKYLNIQACK 278 Score = 75.1 bits (183), Expect = 3e-13 Identities = 64/221 (28%), Positives = 104/221 (47%), Gaps = 34/221 (15%) Query: 169 LYLDKNQIKTF-QGADSGDLLGLEILSLQENGLSSLPSE--------------------- 206 L L +++ F +GA + DL L N LS +P E Sbjct: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121 Query: 207 --IQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264 I L L LN+S N +S +P + L ++ L NN + + P ++ L +L L + Sbjct: 122 EAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDV 180 Query: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRE 324 N+++ IP + +L+ LR LN+ N L P+ L LP LI LD + N I+++P R Sbjct: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELP-LIRLDFSCNKITTIPVCYRN 239 Query: 325 LKNLETLLMDHNKLTFL--------AVEIFQLLKIKELQLA 357 L++L+T+ +D+N L V IF+ L I+ ++A Sbjct: 240 LRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIA 280 Score = 69.7 bits (169), Expect = 1e-11 Identities = 53/192 (27%), Positives = 91/192 (47%), Gaps = 7/192 (3%) Query: 118 SHETVGEVSPQVSEENQKQLGLGADNFT----VNLEAKGLQEFPKDILKIKYVKYLYLDK 173 +H+ +S ++ + A +F +NL ++ P+ IL ++ + +L + + Sbjct: 78 NHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISR 137 Query: 174 NQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQL 233 NQ+ T L L++L N L SLP EI L +L L+VS N I IP +I L Sbjct: 138 NQLSTLPVHLCN--LPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNL 195 Query: 234 GNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLT 293 +R L N++ + P +L L + L NK+ IP +L+ L+ + L+ N L Sbjct: 196 EALRDLNVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQ 254 Query: 294 TFPKALCFLPKL 305 + P +C K+ Sbjct: 255 SPPAQICIKGKV 266 Score = 60.5 bits (145), Expect = 7e-09 Identities = 39/118 (33%), Positives = 60/118 (50%), Gaps = 3/118 (2%) Query: 624 LQSLEQLNISQIKGRKLTRLPGELSN--MTQLKELDISNNAIREIPRNIGELRNLVSLHA 681 L+ + + GRKL P +N +T D+S N + EIP +L +L+ Sbjct: 53 LEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNL 112 Query: 682 YNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739 Y N I Y+P ++L+L L LN+S N L+ LP + N+ LK + +N L+ P EI Sbjct: 113 YQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEI 169 >gi|157694513 leucine-rich repeat-containing G protein-coupled receptor 4 [Homo sapiens] Length = 951 Score = 107 bits (267), Expect = 5e-23 Identities = 128/465 (27%), Positives = 209/465 (44%), Gaps = 67/465 (14%) Query: 255 CLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPK-ALCFLPKLISLDLTGN 313 C G+ + GK L +P+ L + + L++ N +T P+ A P L L L GN Sbjct: 35 CDGDRRVDCSGKG-LTAVPEGLSAFT--QALDISMNNITQLPEDAFKNFPFLEELQLAGN 91 Query: 314 LISSL-PKEIRELKNLETLLMDHNKLTFLAVEIFQ-LLKIKELQLADNKL-EVISHKIEN 370 +S + PK + LK L+ L + +N+L + E + L ++ L+L N + V E Sbjct: 92 DLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEG 151 Query: 371 FRELRILILDKNLLKNIP-EKISCCAMLECLSLSDNKLTELPKYIH-KLNNLRKLHVNRN 428 +LR L LD N L +P +S L+ L+L+ NK++ +P + L++L LH++ N Sbjct: 152 LVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN 211 Query: 429 NMVKITD-CISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALD 487 + ++ C L+N+ +L+ L+YN + FP + AL Sbjct: 212 KIRSLSQHCFDGLDNLETLD-----------------------LNYNNLGEFPQAIKALP 248 Query: 488 SLYYLSVNGNYISEIPVDISFSKQLLH-LELSENKL-LIFSEHFCSLINLKYLDL-GKNQ 544 SL L + N IS IP LL + L +N L + + F +L +L L + G + Sbjct: 249 SLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASM 308 Query: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLEN-LQVLDLSENQLQKISSDICNLKG 603 +++ P +++ + L L L K + P LC + L+ LDLS N ++ D+ + G Sbjct: 309 VQQFP-NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIR----DLPSFNG 363 Query: 604 IQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAI 663 L + SL++ I QIK G + L+ LD+S N I Sbjct: 364 CHAL---------------EEISLQRNQIYQIK-------EGTFQGLISLRILDLSRNLI 401 Query: 664 REI-PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGN 707 EI R L + +L N+++ P LN L QL L GN Sbjct: 402 HEIHSRAFATLGPITNLDVSFNELTSFPTE--GLNGLNQLKLVGN 444 Score = 93.2 bits (230), Expect = 9e-19 Identities = 101/397 (25%), Positives = 173/397 (43%), Gaps = 41/397 (10%) Query: 138 GLGADNFTVNLEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQ 196 GL A +++ + + P+D K +++ L L N + L L++L+LQ Sbjct: 54 GLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQ 113 Query: 197 ENGLSSLPSE-IQLLHNLRILNVSHNHISHIPKEISQ-LGNIRQLFFYNNYIENFP-SDL 253 N L ++PSE I+ L L+ L + NHI+ +P++ + L +R L+ +N + P L Sbjct: 114 NNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPL 173 Query: 254 ECLGNLEILSLGKNKLRHIPD-------------------------TLPSLKTLRVLNLE 288 L L+ L+L NK+ IPD L L L+L Sbjct: 174 SNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLN 233 Query: 289 YNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKN-LETLLMDHNKLTFLAVEIF- 346 YN L FP+A+ LP L L N IS +P + L T+ + N L+F+ F Sbjct: 234 YNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFH 293 Query: 347 QLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC---AMLECLSLS 403 L + L + + + L L L + +IP + C ML L LS Sbjct: 294 NLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNL--CQEQKMLRTLDLS 351 Query: 404 DNKLTELPKYIHKLNNLRKLHVNRNNMVKITD-CISHLNNICSLEFSGNIITDVPIE-IK 461 N + +LP + + + L ++ + RN + +I + L ++ L+ S N+I ++ Sbjct: 352 YNNIRDLPSF-NGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFA 410 Query: 462 NCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNY 498 I +++S+N++ FP L+ L L + GN+ Sbjct: 411 TLGPITNLDVSFNELTSFPTE--GLNGLNQLKLVGNF 445 Score = 80.1 bits (196), Expect = 8e-15 Identities = 72/216 (33%), Positives = 102/216 (47%), Gaps = 21/216 (9%) Query: 538 LDLGKNQIKKIPA-SISNMISLHVLILCCNKFETF-PRELCTLENLQVLDLSENQLQKIS 595 LD+ N I ++P + N L L L N P+ L L+ L+VL L NQL+ + Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121 Query: 596 SD-ICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE-LSNMTQL 653 S+ I L +Q L +N P + + L QL + LT +P LSN+ L Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPED--SFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179 Query: 654 KELDISNNAIREIPR-NIGELRNLVSLHAYNNQISYLPPSLLS-LNDLQQLNLSGNNLTA 711 + L ++ N I IP L +LV LH +NN+I L L++L+ L+L+ NNL Sbjct: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGE 239 Query: 712 LPSAIYNIFSLKEIN-------------FDDNPLLR 734 P AI + SLKE+ FD NPLLR Sbjct: 240 FPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLR 275 Score = 69.3 bits (168), Expect = 1e-11 Identities = 72/282 (25%), Positives = 132/282 (46%), Gaps = 18/282 (6%) Query: 445 SLEFSGNIITDVPIE-IKNCQKIIKIELSYNKIMYF-PLGLCALDSLYYLSVNGNYISEI 502 +L+ S N IT +P + KN + +++L+ N + + P L L L L++ N + + Sbjct: 61 ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV 120 Query: 503 PVD-ISFSKQLLHLELSENKLLIFSEH-FCSLINLKYLDLGKNQIKKIPAS-ISNMISLH 559 P + I L L L N + E F L+ L++L L N + ++P +SN+ +L Sbjct: 121 PSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQ 180 Query: 560 VLILCCNKFETFPRELCT-LENLQVLDLSENQLQKISSDICN-LKGIQKLNFSSNQFIHF 617 L L NK + P T L +L VL L N+++ +S + L ++ L+ + N F Sbjct: 181 ALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF 240 Query: 618 PIELCQLQSLEQLNISQIKGRKLTRLP-GELSNMTQLKELDISNNAIREIPR----NIGE 672 P + L SL++L ++ +P G L+ + + +N + + N+ + Sbjct: 241 PQAIKALPSLKELGFHS---NSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSD 297 Query: 673 LRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPS 714 L +LV A Q P+L L+ L L+G ++++P+ Sbjct: 298 LHSLVIRGASMVQQF---PNLTGTVHLESLTLTGTKISSIPN 336 >gi|4507531 toll-like receptor 3 [Homo sapiens] Length = 904 Score = 107 bits (266), Expect = 6e-23 Identities = 157/620 (25%), Positives = 270/620 (43%), Gaps = 62/620 (10%) Query: 215 ILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS-DLECLGNLEILSLGKNKLRHI- 272 + + SH ++ +P ++ NI L +N + P+ + L L +G N + + Sbjct: 34 VADCSHLKLTQVPDDLPT--NITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLE 91 Query: 273 PDTLPSLKTLRVLNLEYNQLTTFP-KALCFLPKLISLDLTGNLISSLPKE-IRELKNLET 330 P+ L L+VLNL++N+L+ K F L L L N I + + KNL T Sbjct: 92 PELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLIT 151 Query: 331 LLMDHNKL--TFLAVEIFQLLKIKELQLADNKLEVI-SHKIENFRE--LRILILDKNLLK 385 L + HN L T L ++ QL ++EL L++NK++ + S +++ F L+ L L N +K Sbjct: 152 LDLSHNGLSSTKLGTQV-QLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIK 210 Query: 386 NI-PEKISCCAMLECLSLSDNKLTELPKYIHKL------NNLRKLHVNRNNMVKITDCIS 438 P L L L++ +L P KL ++R L ++ N+ + T + Sbjct: 211 EFSPGCFHAIGRLFGLFLNNVQLG--PSLTEKLCLELANTSIRNLSLS-NSQLSTTSNTT 267 Query: 439 HLN----NICSLEFSGNIITDVPIE-IKNCQKIIKIELSYNKIMY-FPLGLCALDSLYYL 492 L N+ L+ S N + V + ++ L YN I + F L L ++ YL Sbjct: 268 FLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYL 327 Query: 493 SVNGNY------ISEIPVDISFSKQLL----HLELSENKLL-IFSEHFCSLINLKYLDLG 541 ++ ++ ++ +P FS Q L HL + +N + I S F LINLKYL L Sbjct: 328 NLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLS 387 Query: 542 KNQIKKIPASISNMISL-----HVLILCCNKFETFPRELCT-LENLQVLDLSENQL--QK 593 + + +SL H+L L NK + + L +L+VLDL N++ + Sbjct: 388 NSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQEL 447 Query: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQL-QSLEQLNISQIKGRKLTRLPGELSNMTQ 652 + L+ I ++ S N+++ L SL++L + ++ + + P + Sbjct: 448 TGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRN 507 Query: 653 LKELDISNNAIREIPRNIGE-LRNLVSLHAYNNQISYLPPS---------LLSLNDLQQL 702 L LD+SNN I I ++ E L L L +N ++ L L L+ L L Sbjct: 508 LTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHIL 567 Query: 703 NLSGNNLTALPSAIY-NIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEK 761 NL N +P ++ ++F LK I+ N L P + + + L Sbjct: 568 NLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQ---VSLKSLNLQKNLITS 624 Query: 762 ILEKIFKIVANNITETNFEF 781 + +K+F N+TE + F Sbjct: 625 VEKKVFGPAFRNLTELDMRF 644 Score = 65.9 bits (159), Expect = 2e-10 Identities = 134/541 (24%), Positives = 220/541 (40%), Gaps = 117/541 (21%) Query: 117 LSHETVG--EVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKN 174 LSH + ++ QV EN ++L L N + + L+ DI +K L L N Sbjct: 154 LSHNGLSSTKLGTQVQLENLQELLLS------NNKIQALKSEELDIFANSSLKKLELSSN 207 Query: 175 QIKTFQGA---DSGDLLGLEILSLQENGLSSLPSEIQLLH-NLRILNVSHNHISHIPKEI 230 QIK F G L GL + ++Q + ++L + ++R L++S++ +S Sbjct: 208 QIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLS-TTSNT 266 Query: 231 SQLG----NIRQL-FFYNNYIENFPSDLECLGNLEILSLGKNKLRHI-PDTLPSLKTLRV 284 + LG N+ L YNN L LE L N ++H+ +L L +R Sbjct: 267 TFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRY 326 Query: 285 LNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPK----EIRELKNLETLLMDHNKLTF 340 LNL+ + F + ISL +SLPK + LK LE L M+ N + Sbjct: 327 LNLKRS----------FTKQSISL-------ASLPKIDDFSFQWLKCLEHLNMEDNDIPG 369 Query: 341 LAVEIFQ-LLKIKELQLADNKLEVISHKIENF-----RELRILILDKNLLKNIP-EKISC 393 + +F L+ +K L L+++ + + E F L IL L KN + I + S Sbjct: 370 IKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSW 429 Query: 394 CAMLECLSLSDNKLTE-------------------LPKYIHKLNN-------LRKLHVNR 427 LE L L N++ + KY+ N L++L + R Sbjct: 430 LGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRR 489 Query: 428 ---NNMVKITDCISHLNNICSLEFSGNIITDVPIE-IKNCQKIIKIELSYNKI------- 476 N+ L N+ L+ S N I ++ + ++ +K+ ++L +N + Sbjct: 490 VALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHA 549 Query: 477 -----MYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCS 531 +YF GL L+ L++ N EIPV++ F Sbjct: 550 NPGGPIYFLKGL---SHLHILNLESNGFDEIPVEV----------------------FKD 584 Query: 532 LINLKYLDLGKNQIKKIPASI-SNMISLHVLILCCNKFETFPRELC--TLENLQVLDLSE 588 L LK +DLG N + +PAS+ +N +SL L L N + +++ NL LD+ Sbjct: 585 LFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRF 644 Query: 589 N 589 N Sbjct: 645 N 645 >gi|21389431 leucine rich repeat containing 39 [Homo sapiens] Length = 335 Score = 106 bits (264), Expect = 1e-22 Identities = 76/265 (28%), Positives = 135/265 (50%), Gaps = 9/265 (3%) Query: 350 KIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409 +IK+L + + HK+ E R+ L + EK++ L + + Sbjct: 21 RIKKLNEDLKREKEFQHKLVRIWEERVS------LTKLREKVTREDGRVILKIEKEEWKT 74 Query: 410 LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469 LP + KLN L++ ++R ++KI + I N+ L+ S N I+++P I ++ ++ Sbjct: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134 Query: 470 ELSYNKIMYFP--LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE 527 LSYNKI P L CA L+VN + I ++P ++S +L HL+LS N Sbjct: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRD-ICDLPQELSNLLKLTHLDLSMNDFTTIPL 193 Query: 528 HFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLS 587 ++ L++LD+G N+++++P +I M +LH L L N+ P+ + ++NL L LS Sbjct: 194 AVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLS 253 Query: 588 ENQLQKISSDICNLKGIQKLNFSSN 612 N+LQ I + + ++ +NF N Sbjct: 254 NNKLQDIPVCMEEMANLRFVNFRDN 278 Score = 103 bits (258), Expect = 5e-22 Identities = 75/246 (30%), Positives = 116/246 (47%), Gaps = 25/246 (10%) Query: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIK 546 D L + +P + QL +L LL E NL LDL +N I Sbjct: 60 DGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTIS 119 Query: 547 KIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606 +IP I + L LIL NK +T P+EL +L+ L+L+ N+ DIC+L Sbjct: 120 EIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNR------DICDL----- 168 Query: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666 P EL L L L++S T +P + NM L+ LD+ +N + ++ Sbjct: 169 -----------PQELSNLLKLTHLDLSM---NDFTTIPLAVLNMPALEWLDMGSNKLEQL 214 Query: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEIN 726 P I ++NL +L N+I+ LP ++ ++ +L L LS N L +P + + +L+ +N Sbjct: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVN 274 Query: 727 FDDNPL 732 F DNPL Sbjct: 275 FRDNPL 280 Score = 101 bits (252), Expect = 3e-21 Identities = 76/239 (31%), Positives = 115/239 (48%), Gaps = 10/239 (4%) Query: 148 LEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEI 207 L K +E + ILKI+ ++ L + +K Q L+ L GL +P I Sbjct: 52 LREKVTREDGRVILKIEKEEWKTLPSSLLKLNQ---------LQEWQLHRTGLLKIPEFI 102 Query: 208 QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKN 267 NL +L++S N IS IP I L +++L N I+ P +L +LE L L N Sbjct: 103 GRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVN 162 Query: 268 K-LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326 + + +P L +L L L+L N TT P A+ +P L LD+ N + LP I ++ Sbjct: 163 RDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQ 222 Query: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLK 385 NL TL + N++T L I + + L L++NKL+ I +E LR + N LK Sbjct: 223 NLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281 Score = 92.8 bits (229), Expect = 1e-18 Identities = 63/220 (28%), Positives = 108/220 (49%), Gaps = 2/220 (0%) Query: 215 ILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274 IL + +P + +L +++ + + P + NL +L L +N + IP Sbjct: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123 Query: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL-ISSLPKEIRELKNLETLLM 333 + L L+ L L YN++ T PK L L L+L N I LP+E+ L L L + Sbjct: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183 Query: 334 DHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISC 393 N T + + + + ++ L + NKLE + IE + L L L +N + +P+ IS Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243 Query: 394 CAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKI 433 L L LS+NKL ++P + ++ NLR ++ R+N +K+ Sbjct: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNF-RDNPLKL 282 Score = 90.9 bits (224), Expect = 5e-18 Identities = 74/260 (28%), Positives = 128/260 (49%), Gaps = 5/260 (1%) Query: 376 ILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITD 435 IL ++K K +P + L+ L L ++P++I + NL L ++RN + +I Sbjct: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123 Query: 436 CISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNK-IMYFPLGLCALDSLYYLSV 494 I L + L S N I VP E+ NC + K+EL+ N+ I P L L L +L + Sbjct: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183 Query: 495 NGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN 554 + N + IP+ + L L++ NKL + + NL L L +N+I +P +ISN Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243 Query: 555 MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI---QKLNFSS 611 M +L L+L NK + P + + NL+ ++ +N L K+ + +G ++ Sbjct: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL-KLKVSLPPSEGTDEEEERELFG 302 Query: 612 NQFIHFPIELCQLQSLEQLN 631 QF+H I+ + ++ Q+N Sbjct: 303 LQFMHTYIQESRRRADHQVN 322 Score = 85.9 bits (211), Expect = 1e-16 Identities = 63/216 (29%), Positives = 104/216 (48%), Gaps = 6/216 (2%) Query: 247 ENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLI 306 + PS L L L+ L + L IP+ + + L VL+L N ++ P + L +L Sbjct: 73 KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132 Query: 307 SLDLTGNLISSLPKEIRELKNLETLLMDHNK-LTFLAVEIFQLLKIKELQLADNKLEVIS 365 L L+ N I ++PKE+ +LE L + N+ + L E+ LLK+ L L+ N I Sbjct: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192 Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425 + N L L + N L+ +P+ I L L L N++T LP+ I + NL L + Sbjct: 193 LAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVL 252 Query: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIK 461 + N + I C+ + N+ + F N P+++K Sbjct: 253 SNNKLQDIPVCMEEMANLRFVNFRDN-----PLKLK 283 Score = 31.6 bits (70), Expect = 3.3 Identities = 47/188 (25%), Positives = 75/188 (39%), Gaps = 19/188 (10%) Query: 639 KLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLND 698 KL R+ E ++T+L+E ++ R G V L + LP SLL LN Sbjct: 38 KLVRIWEERVSLTKLRE---------KVTREDGR----VILKIEKEEWKTLPSSLLKLNQ 84 Query: 699 LQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADER 758 LQ+ L L +P I +L ++ N + P I +L + + Sbjct: 85 LQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTV 144 Query: 759 DEKI-----LEKIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTVSLSERAHQALVI 813 +++ LEK+ V +I + E L L L + + M +T+ L+ AL Sbjct: 145 PKELSNCASLEKLELAVNRDICDLPQE-LSNLLKLTHLDLSMNDFTTIPLAVLNMPALEW 203 Query: 814 WKTQSNKL 821 SNKL Sbjct: 204 LDMGSNKL 211 >gi|62241040 leucine rich repeat containing 8 family, member A [Homo sapiens] Length = 810 Score = 106 bits (264), Expect = 1e-22 Identities = 96/372 (25%), Positives = 170/372 (45%), Gaps = 36/372 (9%) Query: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK-N 327 L IPDT+ L L VL LE T P ++ L L L L + L+ N Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494 Query: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQL-----ADNKLEVISHKIENFRELRILILDKN 382 L L + + + + I+ L ++EL L A+N ++ + + L++L L N Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554 Query: 383 LLKNIPEKISCCAM-LECLSLSDN--KLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439 L K +P+ ++ + L+ LS+++ KL L + K+ NL +L + R ++ +I I Sbjct: 555 LSK-LPQVVTDVGVHLQKLSINNEGTKLIVLNS-LKKMANLTELELIRCDLERIPHSIFS 612 Query: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497 L+N+ ++ N + + I ++ ++ ++L YN I Y P+ + L +L L +N N Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672 Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557 I +IP + + ++L +YLDL N + +PA I + + Sbjct: 673 KIEKIPTQLFYCRKL-----------------------RYLDLSHNNLTFLPADIGLLQN 709 Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617 L L + N+ ET P EL L+ L L N LQ + S + L + ++ N+ Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769 Query: 618 PIELCQLQSLEQ 629 P+EL + L++ Sbjct: 770 PVELGECPLLKR 781 Score = 103 bits (257), Expect = 7e-22 Identities = 129/511 (25%), Positives = 212/511 (41%), Gaps = 38/511 (7%) Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304 Y+ N D++C ++E L+ R P ++L Y L F +C Sbjct: 285 YVHNIKFDVDCTVDIESLT----GYRTYRCAHPLATLFKILASFYISLVIFYGLICMYT- 339 Query: 305 LISLDLTGNLISSLPK----EIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360 L L SL K IRE + + N F+ I Q + + A Sbjct: 340 -----LWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFL 394 Query: 361 LEVISHKIENFRELRILILDK---NLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKL 417 EV +K+ LDK L KN +K+ + L+ +P + L Sbjct: 395 SEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFM---------LSGIPDTVFDL 445 Query: 418 NNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT-DVPIEIKNCQKIIKIELSYNKI 476 L L + V I I+ L + L + P + + + + + I Sbjct: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505 Query: 477 MYFPLGLCALDSLYYLSVNGNYISE----IPVD-ISFSKQLLHLELSENKLLIFSEHFCS 531 PL + +L +L L + GN +E I +D + K+L L L N + Sbjct: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV 565 Query: 532 LINLKYLDLGKNQIKKIPA-SISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQ 590 ++L+ L + K I S+ M +L L L E P + +L NLQ +DL +N Sbjct: 566 GVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNN 625 Query: 591 LQKISSDIC--NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELS 648 L+ I I +L + L N + PI++ L +LE+L +++ K+ ++P +L Sbjct: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR---NKIEKIPTQLF 682 Query: 649 NMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNN 708 +L+ LD+S+N + +P +IG L+NL +L N+I LPP L L+ L+L N Sbjct: 683 YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNV 742 Query: 709 LTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739 L +LPS + + +L +I N L PVE+ Sbjct: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVEL 773 Score = 100 bits (249), Expect = 6e-21 Identities = 106/391 (27%), Positives = 173/391 (44%), Gaps = 25/391 (6%) Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367 L+L ++S +P + +L LE L ++ + I QL +KEL L ++ + Sbjct: 428 LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPA 487 Query: 368 IENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVN 426 + RE LR L + +K IP I LE L L+ N E +YI ++ LR+L Sbjct: 488 LAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYI-VIDGLREL--- 543 Query: 427 RNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL 486 +K+ S+L+ + ++TDV + ++ + I K++ L + Sbjct: 544 --KRLKVLRLKSNLSKL------PQVVTDVGVHLQK----LSINNEGTKLIVLN-SLKKM 590 Query: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDLGKNQ 544 +L L + + IP I L ++L +N L E F L L L L N Sbjct: 591 ANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650 Query: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI 604 I IP I N+ +L L L NK E P +L L+ LDLS N L + +DI L+ + Sbjct: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL 710 Query: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR 664 Q L ++N+ P EL Q + L L++ L LP + +T L ++++ N + Sbjct: 711 QNLAITANRIETLPPELFQCRKLRALHLGN---NVLQSLPSRVGELTNLTQIELRGNRLE 767 Query: 665 EIPRNIGE--LRNLVSLHAYNNQISYLPPSL 693 +P +GE L L + + LPP + Sbjct: 768 CLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798 Score = 90.9 bits (224), Expect = 5e-18 Identities = 72/271 (26%), Positives = 128/271 (47%), Gaps = 28/271 (10%) Query: 197 ENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP--SDLE 254 EN + ++ L L++L + N +S +P+ ++ +G Q NN + L+ Sbjct: 530 ENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588 Query: 255 CLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTG 312 + NL L L + L IP ++ SL L+ ++L+ N L T + + F L +L L L Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648 Query: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFR 372 N I+ +P +I L NLE L ++ NK+ + ++F K++ L L+ N L Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT---------- 698 Query: 373 ELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK 432 L D LL+N L+ L+++ N++ LP + + LR LH+ N + Sbjct: 699 ---FLPADIGLLQN----------LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQS 745 Query: 433 ITDCISHLNNICSLEFSGNIITDVPIEIKNC 463 + + L N+ +E GN + +P+E+ C Sbjct: 746 LPSRVGELTNLTQIELRGNRLECLPVELGEC 776 Score = 89.0 bits (219), Expect = 2e-17 Identities = 59/187 (31%), Positives = 97/187 (51%), Gaps = 4/187 (2%) Query: 187 LLGLEILSLQENGLSSLPSEI--QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244 L L+ + L++N L ++ I Q LH L L + +NHI++IP +I L N+ +L+ N Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672 Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304 IE P+ L L L L N L +P + L+ L+ L + N++ T P L K Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732 Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQ--LLKIKELQLADNKLE 362 L +L L N++ SLP + EL NL + + N+L L VE+ + LLK L + ++ Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792 Query: 363 VISHKIE 369 + +++ Sbjct: 793 TLPPEVK 799 Score = 84.7 bits (208), Expect = 3e-16 Identities = 72/261 (27%), Positives = 127/261 (48%), Gaps = 7/261 (2%) Query: 143 NFTVNLEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGA-DSGDLLGLEILSLQENGL 200 + T NL A+ + D L+ +K +K L L N K Q D G + L+ LS+ G Sbjct: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQKLSINNEGT 579 Query: 201 SSLP-SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS--DLECLG 257 + + ++ + NL L + + IP I L N++++ +N ++ + L Sbjct: 580 KLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH 639 Query: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317 L L L N + +IP + +L L L L N++ P L + KL LDL+ N ++ Sbjct: 640 RLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699 Query: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377 LP +I L+NL+ L + N++ L E+FQ K++ L L +N L+ + ++ L + Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759 Query: 378 ILDKNLLKNIPEKISCCAMLE 398 L N L+ +P ++ C +L+ Sbjct: 760 ELRGNRLECLPVELGECPLLK 780 >gi|187829877 leucine rich repeat containing 8 family, member A [Homo sapiens] Length = 810 Score = 106 bits (264), Expect = 1e-22 Identities = 96/372 (25%), Positives = 170/372 (45%), Gaps = 36/372 (9%) Query: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK-N 327 L IPDT+ L L VL LE T P ++ L L L L + L+ N Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494 Query: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQL-----ADNKLEVISHKIENFRELRILILDKN 382 L L + + + + I+ L ++EL L A+N ++ + + L++L L N Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554 Query: 383 LLKNIPEKISCCAM-LECLSLSDN--KLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439 L K +P+ ++ + L+ LS+++ KL L + K+ NL +L + R ++ +I I Sbjct: 555 LSK-LPQVVTDVGVHLQKLSINNEGTKLIVLNS-LKKMANLTELELIRCDLERIPHSIFS 612 Query: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497 L+N+ ++ N + + I ++ ++ ++L YN I Y P+ + L +L L +N N Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672 Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557 I +IP + + ++L +YLDL N + +PA I + + Sbjct: 673 KIEKIPTQLFYCRKL-----------------------RYLDLSHNNLTFLPADIGLLQN 709 Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617 L L + N+ ET P EL L+ L L N LQ + S + L + ++ N+ Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769 Query: 618 PIELCQLQSLEQ 629 P+EL + L++ Sbjct: 770 PVELGECPLLKR 781 Score = 103 bits (257), Expect = 7e-22 Identities = 129/511 (25%), Positives = 212/511 (41%), Gaps = 38/511 (7%) Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304 Y+ N D++C ++E L+ R P ++L Y L F +C Sbjct: 285 YVHNIKFDVDCTVDIESLT----GYRTYRCAHPLATLFKILASFYISLVIFYGLICMYT- 339 Query: 305 LISLDLTGNLISSLPK----EIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360 L L SL K IRE + + N F+ I Q + + A Sbjct: 340 -----LWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFL 394 Query: 361 LEVISHKIENFRELRILILDK---NLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKL 417 EV +K+ LDK L KN +K+ + L+ +P + L Sbjct: 395 SEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFM---------LSGIPDTVFDL 445 Query: 418 NNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT-DVPIEIKNCQKIIKIELSYNKI 476 L L + V I I+ L + L + P + + + + + I Sbjct: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505 Query: 477 MYFPLGLCALDSLYYLSVNGNYISE----IPVD-ISFSKQLLHLELSENKLLIFSEHFCS 531 PL + +L +L L + GN +E I +D + K+L L L N + Sbjct: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV 565 Query: 532 LINLKYLDLGKNQIKKIPA-SISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQ 590 ++L+ L + K I S+ M +L L L E P + +L NLQ +DL +N Sbjct: 566 GVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNN 625 Query: 591 LQKISSDIC--NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELS 648 L+ I I +L + L N + PI++ L +LE+L +++ K+ ++P +L Sbjct: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR---NKIEKIPTQLF 682 Query: 649 NMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNN 708 +L+ LD+S+N + +P +IG L+NL +L N+I LPP L L+ L+L N Sbjct: 683 YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNV 742 Query: 709 LTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739 L +LPS + + +L +I N L PVE+ Sbjct: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVEL 773 Score = 100 bits (249), Expect = 6e-21 Identities = 106/391 (27%), Positives = 173/391 (44%), Gaps = 25/391 (6%) Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367 L+L ++S +P + +L LE L ++ + I QL +KEL L ++ + Sbjct: 428 LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPA 487 Query: 368 IENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVN 426 + RE LR L + +K IP I LE L L+ N E +YI ++ LR+L Sbjct: 488 LAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYI-VIDGLREL--- 543 Query: 427 RNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL 486 +K+ S+L+ + ++TDV + ++ + I K++ L + Sbjct: 544 --KRLKVLRLKSNLSKL------PQVVTDVGVHLQK----LSINNEGTKLIVLN-SLKKM 590 Query: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDLGKNQ 544 +L L + + IP I L ++L +N L E F L L L L N Sbjct: 591 ANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650 Query: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI 604 I IP I N+ +L L L NK E P +L L+ LDLS N L + +DI L+ + Sbjct: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL 710 Query: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR 664 Q L ++N+ P EL Q + L L++ L LP + +T L ++++ N + Sbjct: 711 QNLAITANRIETLPPELFQCRKLRALHLGN---NVLQSLPSRVGELTNLTQIELRGNRLE 767 Query: 665 EIPRNIGE--LRNLVSLHAYNNQISYLPPSL 693 +P +GE L L + + LPP + Sbjct: 768 CLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798 Score = 90.9 bits (224), Expect = 5e-18 Identities = 72/271 (26%), Positives = 128/271 (47%), Gaps = 28/271 (10%) Query: 197 ENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP--SDLE 254 EN + ++ L L++L + N +S +P+ ++ +G Q NN + L+ Sbjct: 530 ENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588 Query: 255 CLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTG 312 + NL L L + L IP ++ SL L+ ++L+ N L T + + F L +L L L Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648 Query: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFR 372 N I+ +P +I L NLE L ++ NK+ + ++F K++ L L+ N L Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT---------- 698 Query: 373 ELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK 432 L D LL+N L+ L+++ N++ LP + + LR LH+ N + Sbjct: 699 ---FLPADIGLLQN----------LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQS 745 Query: 433 ITDCISHLNNICSLEFSGNIITDVPIEIKNC 463 + + L N+ +E GN + +P+E+ C Sbjct: 746 LPSRVGELTNLTQIELRGNRLECLPVELGEC 776 Score = 89.0 bits (219), Expect = 2e-17 Identities = 59/187 (31%), Positives = 97/187 (51%), Gaps = 4/187 (2%) Query: 187 LLGLEILSLQENGLSSLPSEI--QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244 L L+ + L++N L ++ I Q LH L L + +NHI++IP +I L N+ +L+ N Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672 Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304 IE P+ L L L L N L +P + L+ L+ L + N++ T P L K Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732 Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQ--LLKIKELQLADNKLE 362 L +L L N++ SLP + EL NL + + N+L L VE+ + LLK L + ++ Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792 Query: 363 VISHKIE 369 + +++ Sbjct: 793 TLPPEVK 799 Score = 84.7 bits (208), Expect = 3e-16 Identities = 72/261 (27%), Positives = 127/261 (48%), Gaps = 7/261 (2%) Query: 143 NFTVNLEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGA-DSGDLLGLEILSLQENGL 200 + T NL A+ + D L+ +K +K L L N K Q D G + L+ LS+ G Sbjct: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQKLSINNEGT 579 Query: 201 SSLP-SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS--DLECLG 257 + + ++ + NL L + + IP I L N++++ +N ++ + L Sbjct: 580 KLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH 639 Query: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317 L L L N + +IP + +L L L L N++ P L + KL LDL+ N ++ Sbjct: 640 RLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699 Query: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377 LP +I L+NL+ L + N++ L E+FQ K++ L L +N L+ + ++ L + Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759 Query: 378 ILDKNLLKNIPEKISCCAMLE 398 L N L+ +P ++ C +L+ Sbjct: 760 ELRGNRLECLPVELGECPLLK 780 >gi|187829871 leucine rich repeat containing 8 family, member A [Homo sapiens] Length = 810 Score = 106 bits (264), Expect = 1e-22 Identities = 96/372 (25%), Positives = 170/372 (45%), Gaps = 36/372 (9%) Query: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK-N 327 L IPDT+ L L VL LE T P ++ L L L L + L+ N Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494 Query: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQL-----ADNKLEVISHKIENFRELRILILDKN 382 L L + + + + I+ L ++EL L A+N ++ + + L++L L N Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554 Query: 383 LLKNIPEKISCCAM-LECLSLSDN--KLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439 L K +P+ ++ + L+ LS+++ KL L + K+ NL +L + R ++ +I I Sbjct: 555 LSK-LPQVVTDVGVHLQKLSINNEGTKLIVLNS-LKKMANLTELELIRCDLERIPHSIFS 612 Query: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497 L+N+ ++ N + + I ++ ++ ++L YN I Y P+ + L +L L +N N Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672 Query: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557 I +IP + + ++L +YLDL N + +PA I + + Sbjct: 673 KIEKIPTQLFYCRKL-----------------------RYLDLSHNNLTFLPADIGLLQN 709 Query: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617 L L + N+ ET P EL L+ L L N LQ + S + L + ++ N+ Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769 Query: 618 PIELCQLQSLEQ 629 P+EL + L++ Sbjct: 770 PVELGECPLLKR 781 Score = 103 bits (257), Expect = 7e-22 Identities = 129/511 (25%), Positives = 212/511 (41%), Gaps = 38/511 (7%) Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304 Y+ N D++C ++E L+ R P ++L Y L F +C Sbjct: 285 YVHNIKFDVDCTVDIESLT----GYRTYRCAHPLATLFKILASFYISLVIFYGLICMYT- 339 Query: 305 LISLDLTGNLISSLPK----EIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360 L L SL K IRE + + N F+ I Q + + A Sbjct: 340 -----LWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFL 394 Query: 361 LEVISHKIENFRELRILILDK---NLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKL 417 EV +K+ LDK L KN +K+ + L+ +P + L Sbjct: 395 SEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFM---------LSGIPDTVFDL 445 Query: 418 NNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT-DVPIEIKNCQKIIKIELSYNKI 476 L L + V I I+ L + L + P + + + + + I Sbjct: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505 Query: 477 MYFPLGLCALDSLYYLSVNGNYISE----IPVD-ISFSKQLLHLELSENKLLIFSEHFCS 531 PL + +L +L L + GN +E I +D + K+L L L N + Sbjct: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV 565 Query: 532 LINLKYLDLGKNQIKKIPA-SISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQ 590 ++L+ L + K I S+ M +L L L E P + +L NLQ +DL +N Sbjct: 566 GVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNN 625 Query: 591 LQKISSDIC--NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELS 648 L+ I I +L + L N + PI++ L +LE+L +++ K+ ++P +L Sbjct: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR---NKIEKIPTQLF 682 Query: 649 NMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNN 708 +L+ LD+S+N + +P +IG L+NL +L N+I LPP L L+ L+L N Sbjct: 683 YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNV 742 Query: 709 LTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739 L +LPS + + +L +I N L PVE+ Sbjct: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVEL 773 Score = 100 bits (249), Expect = 6e-21 Identities = 106/391 (27%), Positives = 173/391 (44%), Gaps = 25/391 (6%) Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367 L+L ++S +P + +L LE L ++ + I QL +KEL L ++ + Sbjct: 428 LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPA 487 Query: 368 IENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVN 426 + RE LR L + +K IP I LE L L+ N E +YI ++ LR+L Sbjct: 488 LAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYI-VIDGLREL--- 543 Query: 427 RNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL 486 +K+ S+L+ + ++TDV + ++ + I K++ L + Sbjct: 544 --KRLKVLRLKSNLSKL------PQVVTDVGVHLQK----LSINNEGTKLIVLN-SLKKM 590 Query: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDLGKNQ 544 +L L + + IP I L ++L +N L E F L L L L N Sbjct: 591 ANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650 Query: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI 604 I IP I N+ +L L L NK E P +L L+ LDLS N L + +DI L+ + Sbjct: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL 710 Query: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR 664 Q L ++N+ P EL Q + L L++ L LP + +T L ++++ N + Sbjct: 711 QNLAITANRIETLPPELFQCRKLRALHLGN---NVLQSLPSRVGELTNLTQIELRGNRLE 767 Query: 665 EIPRNIGE--LRNLVSLHAYNNQISYLPPSL 693 +P +GE L L + + LPP + Sbjct: 768 CLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798 Score = 90.9 bits (224), Expect = 5e-18 Identities = 72/271 (26%), Positives = 128/271 (47%), Gaps = 28/271 (10%) Query: 197 ENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP--SDLE 254 EN + ++ L L++L + N +S +P+ ++ +G Q NN + L+ Sbjct: 530 ENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588 Query: 255 CLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTG 312 + NL L L + L IP ++ SL L+ ++L+ N L T + + F L +L L L Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648 Query: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFR 372 N I+ +P +I L NLE L ++ NK+ + ++F K++ L L+ N L Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT---------- 698 Query: 373 ELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK 432 L D LL+N L+ L+++ N++ LP + + LR LH+ N + Sbjct: 699 ---FLPADIGLLQN----------LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQS 745 Query: 433 ITDCISHLNNICSLEFSGNIITDVPIEIKNC 463 + + L N+ +E GN + +P+E+ C Sbjct: 746 LPSRVGELTNLTQIELRGNRLECLPVELGEC 776 Score = 89.0 bits (219), Expect = 2e-17 Identities = 59/187 (31%), Positives = 97/187 (51%), Gaps = 4/187 (2%) Query: 187 LLGLEILSLQENGLSSLPSEI--QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244 L L+ + L++N L ++ I Q LH L L + +NHI++IP +I L N+ +L+ N Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672 Query: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304 IE P+ L L L L N L +P + L+ L+ L + N++ T P L K Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732 Query: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQ--LLKIKELQLADNKLE 362 L +L L N++ SLP + EL NL + + N+L L VE+ + LLK L + ++ Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792 Query: 363 VISHKIE 369 + +++ Sbjct: 793 TLPPEVK 799 Score = 84.7 bits (208), Expect = 3e-16 Identities = 72/261 (27%), Positives = 127/261 (48%), Gaps = 7/261 (2%) Query: 143 NFTVNLEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGA-DSGDLLGLEILSLQENGL 200 + T NL A+ + D L+ +K +K L L N K Q D G + L+ LS+ G Sbjct: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQKLSINNEGT 579 Query: 201 SSLP-SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS--DLECLG 257 + + ++ + NL L + + IP I L N++++ +N ++ + L Sbjct: 580 KLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH 639 Query: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317 L L L N + +IP + +L L L L N++ P L + KL LDL+ N ++ Sbjct: 640 RLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699 Query: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377 LP +I L+NL+ L + N++ L E+FQ K++ L L +N L+ + ++ L + Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759 Query: 378 ILDKNLLKNIPEKISCCAMLE 398 L N L+ +P ++ C +L+ Sbjct: 760 ELRGNRLECLPVELGECPLLK 780 >gi|197333706 leucine rich repeat containing 8 family, member D [Homo sapiens] Length = 858 Score = 105 bits (262), Expect = 2e-22 Identities = 105/394 (26%), Positives = 184/394 (46%), Gaps = 48/394 (12%) Query: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-- 257 LS +P + L +L +L + + IP +ISQ+ N+++L ++ + P+ +E Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQEL-----HLCHCPAKVEQTAFS 533 Query: 258 ----NLEILSLGKNKLRHIPDTLPSLKTLRVL------NLEYNQLTTFPKALCFLPKLIS 307 +L L + + IP + LK LR L N E N++ ++L L L Sbjct: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGL-ESLRELRHLKI 592 Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAV--EIFQLLKIKELQLADNKLEVIS 365 L + NL + +P I ++ T L+ HN T L V + +++ + EL+L + +LE I Sbjct: 593 LHVKSNL-TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIP 651 Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKL 423 H I + L+ L L N ++ I E IS + L CL L NK+ +P Sbjct: 652 HAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPP----------- 700 Query: 424 HVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGL 483 I+H+ N+ SL FS N + +P+ + + QK+ +++SYN I P+ + Sbjct: 701 ------------SITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEI 748 Query: 484 CALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKN 543 L +L +L + GN + +P + +L L L +N + E L L L+L N Sbjct: 749 GLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGN 808 Query: 544 QIKKIPASIS--NMISLHVLILCCNKFETFPREL 575 + ++PA + M+ L++ + F+T P E+ Sbjct: 809 CLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842 Score = 102 bits (253), Expect = 2e-21 Identities = 101/387 (26%), Positives = 167/387 (43%), Gaps = 47/387 (12%) Query: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVK----------ITDCISHLNNICSLEFSGN 451 +S+NKL E+ + H++RN K + D + L ++ L+ Sbjct: 441 VSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELI 500 Query: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL-DSLYYLSVNGNYISEIPVDISFSK 510 +P +I + ++ L + L D L L V ++EIP + K Sbjct: 501 PEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLK 560 Query: 511 QLLHLEL-----SENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN----------- 554 L L L SEN +I E L +LK L + K+ + K+P++I++ Sbjct: 561 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIH 619 Query: 555 --------------MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC- 599 M+++ L L + E P + +L NLQ LDL N ++ I I Sbjct: 620 NDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISF 679 Query: 600 -NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDI 658 +LK + L N+ + P + +++LE L S KL LP + ++ +L+ LD+ Sbjct: 680 QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSN---NKLESLPVAVFSLQKLRCLDV 736 Query: 659 SNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYN 718 S N I IP IG L+NL LH N++ LP L L+ LNL N +T+LP + Sbjct: 737 SYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQ 796 Query: 719 IFSLKEINFDDNPLLRPPVEICKGKQL 745 + L ++ N L R P ++ + + L Sbjct: 797 LSQLTQLELKGNCLDRLPAQLGQCRML 823 Score = 99.8 bits (247), Expect = 1e-20 Identities = 87/336 (25%), Positives = 155/336 (46%), Gaps = 37/336 (11%) Query: 191 EILSLQENGLSSLPSEIQ------LLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244 ++ +LQE L P++++ L +LR L+V ++ IP + L N+R+L+ N Sbjct: 511 QMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN 570 Query: 245 Y-IENFP----SDLECLGNLEILSLGKNKLR---HIPDTLPSLKTLRV------------ 284 EN L L +L+IL + N + +I D P L L + Sbjct: 571 LNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNS 630 Query: 285 ---------LNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEI--RELKNLETLLM 333 L L+ +L P A+ L L LDL N I ++ + I + LK L L + Sbjct: 631 LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKL 690 Query: 334 DHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISC 393 HNK+ + I + ++ L ++NKLE + + + ++LR L + N + IP +I Sbjct: 691 WHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGL 750 Query: 394 CAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNII 453 L+ L ++ NK+ LPK + K LR L++ +N + + + + L+ + LE GN + Sbjct: 751 LQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCL 810 Query: 454 TDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSL 489 +P ++ C+ + K L ++ L L ++L Sbjct: 811 DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEAL 846 Score = 98.6 bits (244), Expect = 2e-20 Identities = 76/276 (27%), Positives = 137/276 (49%), Gaps = 9/276 (3%) Query: 155 EFPKDILKIKYVKYLYLDKN---QIKTFQGADS-GDLLGLEILSLQENGLSSLPSEIQLL 210 E P + +K ++ LYL N + G +S +L L+IL ++ N L+ +PS I + Sbjct: 551 EIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDV 609 Query: 211 HNLRILNVSHNHISH--IPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNK 268 V HN + + + ++ N+ +L N +E P + L NL+ L L N Sbjct: 610 APHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNN 669 Query: 269 LRHIPDTLP--SLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326 +R I + + LK L L L +N++ T P ++ + L SL + N + SLP + L+ Sbjct: 670 IRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQ 729 Query: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKN 386 L L + +N ++ + +EI L ++ L + NK++++ ++ +LR L L +N + + Sbjct: 730 KLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITS 789 Query: 387 IPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRK 422 +PEK+ + L L L N L LP + + L+K Sbjct: 790 LPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKK 825 Score = 93.2 bits (230), Expect = 9e-19 Identities = 99/418 (23%), Positives = 174/418 (41%), Gaps = 77/418 (18%) Query: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373 ++S +P + +L +L+ L ++ + +I Q+ ++EL L +V R+ Sbjct: 478 MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRD 537 Query: 374 LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV-----NRN 428 L CL + + E+P +++ L NLR+L++ + N Sbjct: 538 ----------------------HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSEN 575 Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488 N + + + L ++ L N+ T VP I + + + +N D Sbjct: 576 NKMIGLESLRELRHLKILHVKSNL-TKVPSNITDVAPHLTKLVIHN------------DG 622 Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548 L +N + + LEL +L SL NL+ LDL N I+ I Sbjct: 623 TKLLVLNS---------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTI 673 Query: 549 PASIS--NMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606 IS ++ L L L NK T P + ++NL+ L S N+L+ + + +L+ ++ Sbjct: 674 EEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRC 733 Query: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666 L+ S N PIE+ LQ+L+ L+I+ G K+ LP +L +L+ L++ N I + Sbjct: 734 LDVSYNNISMIPIEIGLLQNLQHLHIT---GNKVDILPKQLFKCIKLRTLNLGQNCITSL 790 Query: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKE 724 P +G+L + L QL L GN L LP+ + LK+ Sbjct: 791 PEKVGQL-----------------------SQLTQLELKGNCLDRLPAQLGQCRMLKK 825 >gi|34222199 leucine rich repeat containing 8 family, member D [Homo sapiens] Length = 858 Score = 105 bits (262), Expect = 2e-22 Identities = 105/394 (26%), Positives = 184/394 (46%), Gaps = 48/394 (12%) Query: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-- 257 LS +P + L +L +L + + IP +ISQ+ N+++L ++ + P+ +E Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQEL-----HLCHCPAKVEQTAFS 533 Query: 258 ----NLEILSLGKNKLRHIPDTLPSLKTLRVL------NLEYNQLTTFPKALCFLPKLIS 307 +L L + + IP + LK LR L N E N++ ++L L L Sbjct: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGL-ESLRELRHLKI 592 Query: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAV--EIFQLLKIKELQLADNKLEVIS 365 L + NL + +P I ++ T L+ HN T L V + +++ + EL+L + +LE I Sbjct: 593 LHVKSNL-TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIP 651 Query: 366 HKIENFRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKL 423 H I + L+ L L N ++ I E IS + L CL L NK+ +P Sbjct: 652 HAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPP----------- 700 Query: 424 HVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGL 483 I+H+ N+ SL FS N + +P+ + + QK+ +++SYN I P+ + Sbjct: 701 ------------SITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEI 748 Query: 484 CALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKN 543 L +L +L + GN + +P + +L L L +N + E L L L+L N Sbjct: 749 GLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGN 808 Query: 544 QIKKIPASIS--NMISLHVLILCCNKFETFPREL 575 + ++PA + M+ L++ + F+T P E+ Sbjct: 809 CLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842 Score = 102 bits (253), Expect = 2e-21 Identities = 101/387 (26%), Positives = 167/387 (43%), Gaps = 47/387 (12%) Query: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVK----------ITDCISHLNNICSLEFSGN 451 +S+NKL E+ + H++RN K + D + L ++ L+ Sbjct: 441 VSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELI 500 Query: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL-DSLYYLSVNGNYISEIPVDISFSK 510 +P +I + ++ L + L D L L V ++EIP + K Sbjct: 501 PEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLK 560 Query: 511 QLLHLEL-----SENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN----------- 554 L L L SEN +I E L +LK L + K+ + K+P++I++ Sbjct: 561 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIH 619 Query: 555 --------------MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC- 599 M+++ L L + E P + +L NLQ LDL N ++ I I Sbjct: 620 NDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISF 679 Query: 600 -NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDI 658 +LK + L N+ + P + +++LE L S KL LP + ++ +L+ LD+ Sbjct: 680 QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSN---NKLESLPVAVFSLQKLRCLDV 736 Query: 659 SNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYN 718 S N I IP IG L+NL LH N++ LP L L+ LNL N +T+LP + Sbjct: 737 SYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQ 796 Query: 719 IFSLKEINFDDNPLLRPPVEICKGKQL 745 + L ++ N L R P ++ + + L Sbjct: 797 LSQLTQLELKGNCLDRLPAQLGQCRML 823 Score = 99.8 bits (247), Expect = 1e-20 Identities = 87/336 (25%), Positives = 155/336 (46%), Gaps = 37/336 (11%) Query: 191 EILSLQENGLSSLPSEIQ------LLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244 ++ +LQE L P++++ L +LR L+V ++ IP + L N+R+L+ N Sbjct: 511 QMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN 570 Query: 245 Y-IENFP----SDLECLGNLEILSLGKNKLR---HIPDTLPSLKTLRV------------ 284 EN L L +L+IL + N + +I D P L L + Sbjct: 571 LNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNS 630 Query: 285 ---------LNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEI--RELKNLETLLM 333 L L+ +L P A+ L L LDL N I ++ + I + LK L L + Sbjct: 631 LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKL 690 Query: 334 DHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISC 393 HNK+ + I + ++ L ++NKLE + + + ++LR L + N + IP +I Sbjct: 691 WHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGL 750 Query: 394 CAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNII 453 L+ L ++ NK+ LPK + K LR L++ +N + + + + L+ + LE GN + Sbjct: 751 LQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCL 810 Query: 454 TDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSL 489 +P ++ C+ + K L ++ L L ++L Sbjct: 811 DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEAL 846 Score = 98.6 bits (244), Expect = 2e-20 Identities = 76/276 (27%), Positives = 137/276 (49%), Gaps = 9/276 (3%) Query: 155 EFPKDILKIKYVKYLYLDKN---QIKTFQGADS-GDLLGLEILSLQENGLSSLPSEIQLL 210 E P + +K ++ LYL N + G +S +L L+IL ++ N L+ +PS I + Sbjct: 551 EIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDV 609 Query: 211 HNLRILNVSHNHISH--IPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNK 268 V HN + + + ++ N+ +L N +E P + L NL+ L L N Sbjct: 610 APHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNN 669 Query: 269 LRHIPDTLP--SLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326 +R I + + LK L L L +N++ T P ++ + L SL + N + SLP + L+ Sbjct: 670 IRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQ 729 Query: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKN 386 L L + +N ++ + +EI L ++ L + NK++++ ++ +LR L L +N + + Sbjct: 730 KLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITS 789 Query: 387 IPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRK 422 +PEK+ + L L L N L LP + + L+K Sbjct: 790 LPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKK 825 Score = 93.2 bits (230), Expect = 9e-19 Identities = 99/418 (23%), Positives = 174/418 (41%), Gaps = 77/418 (18%) Query: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373 ++S +P + +L +L+ L ++ + +I Q+ ++EL L +V R+ Sbjct: 478 MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRD 537 Query: 374 LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV-----NRN 428 L CL + + E+P +++ L NLR+L++ + N Sbjct: 538 ----------------------HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSEN 575 Query: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488 N + + + L ++ L N+ T VP I + + + +N D Sbjct: 576 NKMIGLESLRELRHLKILHVKSNL-TKVPSNITDVAPHLTKLVIHN------------DG 622 Query: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548 L +N + + LEL +L SL NL+ LDL N I+ I Sbjct: 623 TKLLVLNS---------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTI 673 Query: 549 PASIS--NMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606 IS ++ L L L NK T P + ++NL+ L S N+L+ + + +L+ ++ Sbjct: 674 EEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRC 733 Query: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666 L+ S N PIE+ LQ+L+ L+I+ G K+ LP +L +L+ L++ N I + Sbjct: 734 LDVSYNNISMIPIEIGLLQNLQHLHIT---GNKVDILPKQLFKCIKLRTLNLGQNCITSL 790 Query: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKE 724 P +G+L + L QL L GN L LP+ + LK+ Sbjct: 791 PEKVGQL-----------------------SQLTQLELKGNCLDRLPAQLGQCRMLKK 825 >gi|62912470 leucine-rich repeat-containing G protein-coupled receptor 6 isoform 1 [Homo sapiens] Length = 967 Score = 105 bits (261), Expect = 2e-22 Identities = 120/435 (27%), Positives = 195/435 (44%), Gaps = 64/435 (14%) Query: 285 LNLEYNQLTTF-PKALCFLPKLISLDLTGNLISSLPKE-IRELKNLETLLMDHNKLTFLA 342 L+L N LT P L L L L+GN +S +P + L +L+ L++ +N+L + Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130 Query: 343 VE-IFQLLKIKELQLADNKLEVISHK-IENFRELRILILDKNLLKNIPEK-ISCCAMLEC 399 E +++L ++ L+L N + ++ + E LR L LD N L IP + ++ L+ Sbjct: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190 Query: 400 LSLSDNKLTELPKY-IHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPI 458 ++L+ N+++ +P Y L +L LH++ N I HL S E N+ T Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNR-------IQHLGTH-SFEGLHNLET---- 238 Query: 459 EIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH-LEL 517 ++L+YNK+ FP+ + L L L + N I IP LL + Sbjct: 239 ----------LDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 288 Query: 518 SENKL-LIFSEHFCSLINLKYLDL-GKNQIKKIPASISNMISLHVLILCCNKFETFPREL 575 +N + + F L L L L G I++ P + SL +L L P + Sbjct: 289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIRLLPSGM 347 Query: 576 C-TLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQ 634 C L L+VL+LS NQ++++ S L + Q LE++ + Sbjct: 348 CQQLPRLRVLELSHNQIEELPS------------------------LHRCQKLEEIGLQH 383 Query: 635 IKGRKLTRLPGE-LSNMTQLKELDISNNAIREI-PRNIGELRNLVSLHAYNNQISYLPPS 692 ++ + + S ++ L+ LD+S NAIR I P L +LV L +NQ++ LP Sbjct: 384 ---NRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP-- 438 Query: 693 LLSLNDLQQLNLSGN 707 L L L L L GN Sbjct: 439 LAGLGGLMHLKLKGN 453 Score = 101 bits (251), Expect = 3e-21 Identities = 97/369 (26%), Positives = 169/369 (45%), Gaps = 38/369 (10%) Query: 163 IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSE-IQLLHNLRILNVSHN 221 +++++ L L N + G L L+IL LQ N L +P+E + L +L+ L + N Sbjct: 89 LRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDAN 148 Query: 222 HISHIP-KEISQLGNIRQLFFYNNYIENFP-SDLECLGNLEILSLGKNKLRHIPD----- 274 IS +P + L ++R L+ +N + P L L L+ ++L N++ HIPD Sbjct: 149 LISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQN 208 Query: 275 --------------------TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL 314 + L L L+L YN+L FP A+ L +L L N Sbjct: 209 LTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNN 268 Query: 315 ISSLP-KEIRELKNLETLLMDHNKLTFLAVEIFQLL-KIKELQLADNKLEVISH-KIENF 371 I ++P K L+T+ N + F+ FQ L K+ L L + +++ ++ Sbjct: 269 IKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGT 327 Query: 372 RELRILILDKNLLKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNM 430 L IL L + ++ +P + L L LS N++ ELP +H+ L ++ + N + Sbjct: 328 TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS-LHRCQKLEEIGLQHNRI 386 Query: 431 VKI-TDCISHLNNICSLEFSGNIITDV-PIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488 +I D S L+++ +L+ S N I + P ++K++L+ N++ P L L Sbjct: 387 WEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP--LAGLGG 444 Query: 489 LYYLSVNGN 497 L +L + GN Sbjct: 445 LMHLKLKGN 453 Score = 98.2 bits (243), Expect = 3e-20 Identities = 120/410 (29%), Positives = 188/410 (45%), Gaps = 40/410 (9%) Query: 193 LSLQENGLSSLPSEIQLLHNLRILN---VSHNHISHIP-KEISQLGNIRQLFFYNNYIEN 248 L L N L+ L + L H+LR L +S NH+SHIP + S L +++ L NN + Sbjct: 71 LDLSMNNLTEL--QPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGG 128 Query: 249 FPSD-LECLGNLEILSLGKNKLRHIPD-TLPSLKTLRVLNLEYNQLTTFP-KALCFLPKL 305 P++ L L +L+ L L N + +P+ + L +LR L L+ N LT P +AL LP L Sbjct: 129 IPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPAL 188 Query: 306 ISLDLTGNLISSLPK-EIRELKNLETLLMDHNKLTFLAVEIFQ-LLKIKELQLADNKLEV 363 ++ L N IS +P + L +L L + +N++ L F+ L ++ L L NKL+ Sbjct: 189 QAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQE 248 Query: 364 ISHKIENFRELRILILDKNLLKNIPEK-ISCCAMLECLSLSDNKLTELPKYIHKLNNLRK 422 I L+ L N +K IPEK +L+ + DN + + + L K Sbjct: 249 FPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGR--SAFQYLPK 306 Query: 423 LHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLG 482 LH +L +G + ++K + + L+ I P G Sbjct: 307 LH--------------------TLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG 346 Query: 483 LC-ALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLL-IFSEHFCSLINLKYLDL 540 +C L L L ++ N I E+P + ++L + L N++ I ++ F L +L+ LDL Sbjct: 347 MCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDL 405 Query: 541 GKNQIKKI-PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589 N I+ I P + S + SL L L N+ T P L L L L L N Sbjct: 406 SWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP--LAGLGGLMHLKLKGN 453 Score = 73.6 bits (179), Expect = 8e-13 Identities = 88/368 (23%), Positives = 143/368 (38%), Gaps = 80/368 (21%) Query: 148 LEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSE 206 L+ L E P L + ++ + L N+I +L L +L L N + L + Sbjct: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228 Query: 207 -IQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP--------------- 250 + LHNL L++++N + P I LG +++L F+NN I+ P Sbjct: 229 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 288 Query: 251 ----------SDLECLGNLEILSL-GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL 299 S + L L LSL G ++ PD L +L +L L + P + Sbjct: 289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSGM 347 Query: 300 C-FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIF-QLLKIKELQLA 357 C LP+L L+L+ N I LP + + LE + + HN++ + + F QL ++ L L+ Sbjct: 348 CQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLS 406 Query: 358 DNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKL 417 N + I PE S L L L+DN+LT LP Sbjct: 407 WNAIRSIH----------------------PEAFSTLHSLVKLDLTDNQLTTLP------ 438 Query: 418 NNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIM 477 ++ L + L+ GN+ + K+ +E+ Y Sbjct: 439 -------------------LAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPY-AYQ 478 Query: 478 YFPLGLCA 485 P G+CA Sbjct: 479 CCPYGMCA 486 Score = 67.0 bits (162), Expect = 7e-11 Identities = 68/241 (28%), Positives = 109/241 (45%), Gaps = 11/241 (4%) Query: 499 ISEIPVDISFSKQLLHLELSENKLLIFSEH-FCSLINLKYLDLGKNQIKKIPA-SISNMI 556 +S +P D+ +L+LS N L F L L+ L L N + IP + S + Sbjct: 57 LSAVPGDLD--PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLY 114 Query: 557 SLHVLILCCNKFETFPRE-LCTLENLQVLDLSENQLQKISS-DICNLKGIQKLNFSSNQF 614 SL +L+L N+ P E L L +LQ L L N + + L ++ L N Sbjct: 115 SLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 174 Query: 615 IHFPIELCQLQSLEQLNISQIKGRKLTRLPG-ELSNMTQLKELDISNNAIREIPRNIGE- 672 P+ L +L L + +++ +P N+T L L + NN I+ + + E Sbjct: 175 TEIPVRA--LNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEG 232 Query: 673 LRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALP-SAIYNIFSLKEINFDDNP 731 L NL +L N++ P ++ +L LQ+L NN+ A+P A L+ I+F DNP Sbjct: 233 LHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNP 292 Query: 732 L 732 + Sbjct: 293 I 293 Score = 55.8 bits (133), Expect = 2e-07 Identities = 66/223 (29%), Positives = 93/223 (41%), Gaps = 53/223 (23%) Query: 145 TVNLEAKGLQEFPKDILKIKYVKYLYLDKNQI-----KTFQG------------------ 181 T++L LQEFP I + ++ L N I K F G Sbjct: 238 TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 297 Query: 182 ---------------------ADSGDLLG---LEILSLQENGLSSLPSEI-QLLHNLRIL 216 + DL G LEIL+L G+ LPS + Q L LR+L Sbjct: 298 RSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVL 357 Query: 217 NVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSD-LECLGNLEILSLGKNKLRHI-PD 274 +SHN I +P + + + ++ +N I +D L +L+ L L N +R I P+ Sbjct: 358 ELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416 Query: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317 +L +L L+L NQLTT P L L L+ L L GNL S Sbjct: 417 AFSTLHSLVKLDLTDNQLTTLP--LAGLGGLMHLKLKGNLALS 457 >gi|190014581 leucine rich repeat containing 2 [Homo sapiens] Length = 371 Score = 103 bits (258), Expect = 5e-22 Identities = 74/247 (29%), Positives = 127/247 (51%), Gaps = 28/247 (11%) Query: 488 SLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKK 547 S + ++G + +E+P + L +S + I + ++ LDL KNQI Sbjct: 99 SAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISH 158 Query: 548 IPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN-QLQKISSDICNLKGIQK 606 +PA I + +L L + N ++ P EL ENL+ LD S N +L ++ ++ NLK + Sbjct: 159 LPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTF 218 Query: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666 ++ S+N+F PI C L+ M+ L+ LDIS+N + ++ Sbjct: 219 VDISANKFSSVPI--CVLR------------------------MSNLQWLDISSNNLTDL 252 Query: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFS-LKEI 725 P++I L L S Y N+++YLP S+L+L L L +SG++L LP+A+ + + LK + Sbjct: 253 PQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFV 312 Query: 726 NFDDNPL 732 + DNP+ Sbjct: 313 SLMDNPI 319 Score = 95.1 bits (235), Expect = 2e-19 Identities = 58/212 (27%), Positives = 107/212 (50%), Gaps = 1/212 (0%) Query: 201 SSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLE 260 SSLP + + + +S H + +P + + ++R+ + N I+ P+ ++ + Sbjct: 88 SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMR 147 Query: 261 ILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL-ISSLP 319 IL L KN++ H+P + LK L+ LN+ +N L + P L L LD +GNL + LP Sbjct: 148 ILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELP 207 Query: 320 KEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILIL 379 E+ LK + + + NK + + + + ++ ++ L ++ N L + I+ EL+ +L Sbjct: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLL 267 Query: 380 DKNLLKNIPEKISCCAMLECLSLSDNKLTELP 411 KN L +P + L L +S + L ELP Sbjct: 268 YKNKLTYLPYSMLNLKKLTLLVVSGDHLVELP 299 Score = 86.3 bits (212), Expect = 1e-16 Identities = 65/250 (26%), Positives = 125/250 (50%), Gaps = 10/250 (4%) Query: 281 TLRVLN-LEYNQLT---TFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHN 336 ++R+L+ +E N LT + PK +L+G + LP ++E +L + + Sbjct: 72 SVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNT 131 Query: 337 KLTFLA--VEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC 394 + + +++FQ ++I L L N++ + +I + L+ L + N LK+IP ++ C Sbjct: 132 LIQIIPTYIQLFQAMRI--LDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDC 189 Query: 395 AMLECLSLSDN-KLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNII 453 LE L S N +L ELP + L + + ++ N + C+ ++N+ L+ S N + Sbjct: 190 ENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNL 249 Query: 454 TDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDI-SFSKQL 512 TD+P +I +++ L NK+ Y P + L L L V+G+++ E+P + S L Sbjct: 250 TDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPL 309 Query: 513 LHLELSENKL 522 + L +N + Sbjct: 310 KFVSLMDNPI 319 Score = 84.7 bits (208), Expect = 3e-16 Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 2/227 (0%) Query: 183 DSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFY 242 D G + L + LP ++ +LR +S+ I IP I +R L Sbjct: 93 DRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLP 152 Query: 243 NNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYN-QLTTFPKALCF 301 N I + P+++ CL NL+ L++G N L+ IP L + L L+ N +L P L Sbjct: 153 KNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSN 212 Query: 302 LPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKL 361 L ++ +D++ N SS+P + + NL+ L + N LT L +I +L +++ L NKL Sbjct: 213 LKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKL 272 Query: 362 EVISHKIENFRELRILILDKNLLKNIPEKI-SCCAMLECLSLSDNKL 407 + + + N ++L +L++ + L +P + L+ +SL DN + Sbjct: 273 TYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPI 319 Score = 73.6 bits (179), Expect = 8e-13 Identities = 49/200 (24%), Positives = 97/200 (48%), Gaps = 1/200 (0%) Query: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIK 461 LS TELP + + +LR+ +++ + I I + L+ N I+ +P EI Sbjct: 105 LSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIG 164 Query: 462 NCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNY-ISEIPVDISFSKQLLHLELSEN 520 + + ++ + +N + P L ++L L +GN + E+P ++S KQ+ +++S N Sbjct: 165 CLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISAN 224 Query: 521 KLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLEN 580 K + NL++LD+ N + +P I + L +L NK P + L+ Sbjct: 225 KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKK 284 Query: 581 LQVLDLSENQLQKISSDICN 600 L +L +S + L ++ + +C+ Sbjct: 285 LTLLVVSGDHLVELPTALCD 304 Score = 70.5 bits (171), Expect = 6e-12 Identities = 54/199 (27%), Positives = 92/199 (46%), Gaps = 25/199 (12%) Query: 547 KIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606 ++P S+ L + + P + + +++LDL +NQ+ + ++I LK +++ Sbjct: 112 ELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKE 171 Query: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666 LN N P EL ++LE+L+ S +L LP ELSN+ Q+ +DIS N Sbjct: 172 LNVGFNYLKSIPPELGDCENLERLDCSG--NLELMELPFELSNLKQVTFVDISAN----- 224 Query: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEIN 726 + S +P +L +++LQ L++S NNLT LP I + L+ Sbjct: 225 ------------------KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFL 266 Query: 727 FDDNPLLRPPVEICKGKQL 745 N L P + K+L Sbjct: 267 LYKNKLTYLPYSMLNLKKL 285 Score = 67.0 bits (162), Expect = 7e-11 Identities = 45/156 (28%), Positives = 80/156 (51%), Gaps = 2/156 (1%) Query: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQEN-GLSSLP 204 ++L + P +I +K +K L + N +K+ + GD LE L N L LP Sbjct: 149 LDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIP-PELGDCENLERLDCSGNLELMELP 207 Query: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264 E+ L + +++S N S +P + ++ N++ L +N + + P D++ L L+ L Sbjct: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLL 267 Query: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300 KNKL ++P ++ +LK L +L + + L P ALC Sbjct: 268 YKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALC 303 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.134 0.372 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,539,127 Number of Sequences: 37866 Number of extensions: 1222040 Number of successful extensions: 8735 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 130 Number of HSP's successfully gapped in prelim test: 221 Number of HSP's that attempted gapping in prelim test: 4247 Number of HSP's gapped (non-prelim): 1947 length of query: 860 length of database: 18,247,518 effective HSP length: 111 effective length of query: 749 effective length of database: 14,044,392 effective search space: 10519249608 effective search space used: 10519249608 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.