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Search of human proteins with 238908495
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|238908495 similar to pleckstrin homology domain protein
(5V327) [Homo sapiens]
(506 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|238908495 similar to pleckstrin homology domain protein (5V32... 988 0.0
gi|71061468 centromere protein E [Homo sapiens] 82 9e-16
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 82 1e-15
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 82 1e-15
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 80 4e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 80 4e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 80 4e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 80 4e-15
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 80 6e-15
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 79 1e-14
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 79 1e-14
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 78 2e-14
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 78 2e-14
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 77 4e-14
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 77 4e-14
gi|148746195 trichohyalin [Homo sapiens] 77 5e-14
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 76 8e-14
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 74 2e-13
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 74 3e-13
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 74 4e-13
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 74 4e-13
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 73 5e-13
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 73 7e-13
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 73 7e-13
gi|31982906 cingulin-like 1 [Homo sapiens] 73 7e-13
gi|156104908 myosin heavy chain 6 [Homo sapiens] 72 9e-13
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 71 2e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 71 2e-12
gi|122937396 coiled-coil domain containing 150 [Homo sapiens] 71 2e-12
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 71 3e-12
>gi|238908495 similar to pleckstrin homology domain protein (5V327)
[Homo sapiens]
Length = 506
Score = 988 bits (2555), Expect = 0.0
Identities = 506/506 (100%), Positives = 506/506 (100%)
Query: 1 MFTSKSNSVSPSPSLEQADSDALDISTKVQLYGVLWKRPFGRPSAKWSRRFFIIKESFLL 60
MFTSKSNSVSPSPSLEQADSDALDISTKVQLYGVLWKRPFGRPSAKWSRRFFIIKESFLL
Sbjct: 1 MFTSKSNSVSPSPSLEQADSDALDISTKVQLYGVLWKRPFGRPSAKWSRRFFIIKESFLL 60
Query: 61 YYSESEKKSFETNKYFNIHPKGVIPLGGCLVEPKEEPSMPYAMKISHQDFHGNILLAAES 120
YYSESEKKSFETNKYFNIHPKGVIPLGGCLVEPKEEPSMPYAMKISHQDFHGNILLAAES
Sbjct: 61 YYSESEKKSFETNKYFNIHPKGVIPLGGCLVEPKEEPSMPYAMKISHQDFHGNILLAAES 120
Query: 121 EFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQ 180
EFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQ
Sbjct: 121 EFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQ 180
Query: 181 REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLT 240
REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLT
Sbjct: 181 REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLT 240
Query: 241 ESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLE 300
ESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLE
Sbjct: 241 ESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLE 300
Query: 301 EKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMD 360
EKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMD
Sbjct: 301 EKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMD 360
Query: 361 LERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIM 420
LERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIM
Sbjct: 361 LERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIM 420
Query: 421 KNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKEVAKRLSRD 480
KNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKEVAKRLSRD
Sbjct: 421 KNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKEVAKRLSRD 480
Query: 481 QRFRESIYHIMATQPGAPSALSRGGK 506
QRFRESIYHIMATQPGAPSALSRGGK
Sbjct: 481 QRFRESIYHIMATQPGAPSALSRGGK 506
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 82.4 bits (202), Expect = 9e-16
Identities = 88/393 (22%), Positives = 182/393 (46%), Gaps = 25/393 (6%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELC 178
ES+ +Q Q L M ++ + T +++ + K ++ L++ E +L E +E+
Sbjct: 1381 ESQSKQEQSLNMKEKDNETTKIVSEMEQ--FKPKDSALLRIEIEMLGLSKRLQESHDEMK 1438
Query: 179 LQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRH 238
+++++L+RL +VL++E Q +E ++E+ + + + EL++ CLK E+ ELR
Sbjct: 1439 SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR- 1497
Query: 239 LTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQL 298
+L + E+S +K+ + ++ +N +Q + + EQ N++QI E +++
Sbjct: 1498 --VNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ--------FNIKQISEVQEKV 1547
Query: 299 LEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVR 358
E K E R K + +++E + +++ Q Q +Q + EK++ +R +A R
Sbjct: 1548 NELKQFKEHR-KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIER 1606
Query: 359 MDLERRLREAEGALRSLE----QGLNSKVRNKEKEERMRADVSHLKRFFEE---CIRNAE 411
L+ +E ++ + Q L N E +E+M ++ HLK FE + N E
Sbjct: 1607 DQLKENTKEIVAKMKESQEKEYQFLKMTAVN-ETQEKM-CEIEHLKEQFETQKLNLENIE 1664
Query: 412 LE-AKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEEL 470
E ++ I+ ++ ++ T+ R + +K + T D EEL
Sbjct: 1665 TENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLR-ETITRDLEKQEEL 1723
Query: 471 KEVAKRLSRDQRFRESIYHIMATQPGAPSALSR 503
K V L Q + + I++ + S + +
Sbjct: 1724 KIVHMHLKEHQETIDKLRGIVSEKTNEISNMQK 1756
Score = 72.4 bits (176), Expect = 9e-13
Identities = 67/356 (18%), Positives = 162/356 (45%), Gaps = 29/356 (8%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVV 205
++ ++S+E++ L+L ++L E EE+ + +++EE++R+ + L+ E+ Q +E
Sbjct: 1561 DSALQSIESKMLELT-------NRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT 1613
Query: 206 QEL--RMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQ---TLEELSIEKKKTLEM 260
+E+ +M++ Q K L + +++ E+ HL E + LE + E + ++
Sbjct: 1614 KEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQI 1673
Query: 261 LEENENHLQTLANQSEQ--------PPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKEN 312
L EN ++++ + + L NLR+ + + EE + +KE+
Sbjct: 1674 LHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEH 1733
Query: 313 EERSRALEEEREFYSSQSQALQNSLQELTAEKQQAE-RELKAEVKVRMDLERRLREAEGA 371
+E +++ R S ++ + N ++L + ++LK + ++R+ L+E +
Sbjct: 1734 QE---TIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI-AHMHLKEQQET 1789
Query: 372 LRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAAT 431
+ L ++ K +K M+ D+ + +E I+ + + +K V +
Sbjct: 1790 IDKLRGIVSEKT---DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKV 1846
Query: 432 RRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKEVAKRLSRDQRFRESI 487
++ + + S + + ++ + +L N+EE+K V K +R E++
Sbjct: 1847 SEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH-ENLEEMKSVMKERDNLRRVEETL 1901
Score = 71.6 bits (174), Expect = 2e-12
Identities = 77/367 (20%), Positives = 159/367 (43%), Gaps = 30/367 (8%)
Query: 123 EQTQWLEMLQESGKVTWKNAQLGEAM--IKSLEAQGLQLAKEKQEYLDKLMEETEELCLQ 180
+Q Q L + +E ++ K ++ +K+ E + E+ E KL E EE+
Sbjct: 1139 KQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSI 1198
Query: 181 REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRH-L 239
++R+ L+ L + E E+ ++E+ Q K EL++ LK ++ ELR +
Sbjct: 1199 TKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSV 1258
Query: 240 TESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLL 299
+E Q + +EK T + + + L + E P N++++ E + +
Sbjct: 1259 SEKTAQIINTQDLEKSHT-----KLQEEIPVLHEEQELLP-------NVKEVSETQETMN 1306
Query: 300 EEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRM 359
E +LL E+ ++ +E ER + + Q Q ++ LT E+ + +K ++V+
Sbjct: 1307 ELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL-KTIKEALEVKH 1365
Query: 360 D-LERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPV 418
D L+ +RE ++ + + KEK+ VS +++F + +E +M
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM-- 1423
Query: 419 IMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKE-VAKRL 477
++R++ + + +D++ Q + S+ D E +KE VAK L
Sbjct: 1424 ---------LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESD-QLKENIKEIVAKHL 1473
Query: 478 SRDQRFR 484
++ +
Sbjct: 1474 ETEEELK 1480
Score = 70.9 bits (172), Expect = 3e-12
Identities = 79/334 (23%), Positives = 159/334 (47%), Gaps = 52/334 (15%)
Query: 117 AAESEFEQTQWLEM--LQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEET 174
+ + EF+ + L M Q+ V +N ++ + ++ L+KE Q++ L
Sbjct: 814 STDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVN--------LSKEAQKFDSSLGALK 865
Query: 175 EELC-----LQREQREELERLNQVLEAEKQQFEE---VVQELRMEQEQIKRELELTARCL 226
EL LQ + RE ERLN+ +E K+Q E +Q + E+ I +L+ T +
Sbjct: 866 TELSYKTQELQEKTREVQERLNE-MEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924
Query: 227 KGVEQEKKELRHLTESLQQTLEELSI--------------EKKKTLEMLEENENHLQTLA 272
K + QEK +L+ L ESLQ ++L + + LE L++++ + TL
Sbjct: 925 KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK 984
Query: 273 NQ-SEQPPPSGGLHSNLRQIEEKMQQLL-----EEKLLAE--KRMKENEERSRALEEERE 324
++ SE+ + + N + +++ QQ + ++ L A+ + + + + + +E++R+
Sbjct: 985 SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRK 1044
Query: 325 FYS--SQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSK 382
+S + LQ L+ + AEK+Q + +LK +++ ++ + LR L+ ++ + +
Sbjct: 1045 IFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQE 1104
Query: 383 VRNKEKEERMRADVSHLKRFFEECIRNAELEAKM 416
+ K+E L R C R AE+E K+
Sbjct: 1105 KNHAIKKE------GELSR---TCDRLAEVEEKL 1129
Score = 68.9 bits (167), Expect = 1e-11
Identities = 88/396 (22%), Positives = 171/396 (43%), Gaps = 54/396 (13%)
Query: 131 LQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLD---KLMEETEELCLQREQREEL 187
L++ T K E + K ++ Q L L+K + E L+ KL E EE+ ++R+ L
Sbjct: 1835 LKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNL 1894
Query: 188 ERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQE--------------- 232
R+ + L+ E+ Q +E +QE + +I++EL+ TAR L +E
Sbjct: 1895 RRVEETLKLERDQLKESLQETKARDLEIQQELK-TARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 233 ----KKELRHLTESLQQTLEELSIEKKKTLEMLEENE---------NHLQTLANQSE-QP 278
+K+L + LQ+ ++EL +KK L++L E N ++ L Q E Q
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQEL---QKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQN 2010
Query: 279 PPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQ 338
+ + Q+ +K+ + LEE + K E +L+ ER+ + + +L+
Sbjct: 2011 LSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIA-------TLR 2063
Query: 339 ELTAEKQQAERELKAEVKVRMD----LERRLREAEGALRSLEQGLNSKVRNKEKEERMRA 394
E+ A +Q ++K E ++ D L LRE ++ L + + + E R+
Sbjct: 2064 EMIARDRQ-NHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSL 2122
Query: 395 DVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSW-----N 449
D+ F +E + +P + + A +R S FHR +
Sbjct: 2123 DLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRC-SMEFHRIMKKLKYVLSYVT 2181
Query: 450 DMKPSQSFMTSQLDANNMEELKEVAKRLSRDQRFRE 485
+K Q ++ + + ++E+++ + L + Q ++
Sbjct: 2182 KIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQ 2217
Score = 58.9 bits (141), Expect = 1e-08
Identities = 52/216 (24%), Positives = 112/216 (51%), Gaps = 30/216 (13%)
Query: 161 KEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQI---KR 217
KE+QE +DKL + E+ ++L + + LE + +E +QEL+ + Q+ K+
Sbjct: 1784 KEQQETIDKLRG------IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK 1837
Query: 218 ELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQ 277
++ T + + +EQ KK+++ +SL TL +L IE + L EN ++++ + +
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKD--QSL--TLSKLEIENLNLAQKLHENLEEMKSVMKERD- 1892
Query: 278 PPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEE---REFYSSQSQALQ 334
NLR++EE ++ LE L E ++E + R +++E S + +
Sbjct: 1893 ---------NLRRVEETLK--LERDQLKES-LQETKARDLEIQQELKTARMLSKEHKETV 1940
Query: 335 NSLQELTAEKQQAERELKAEV-KVRMDLERRLREAE 369
+ L+E +EK +++ ++ K + +L+++++E +
Sbjct: 1941 DKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQ 1976
Score = 58.2 bits (139), Expect = 2e-08
Identities = 60/244 (24%), Positives = 109/244 (44%), Gaps = 21/244 (8%)
Query: 158 QLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKR 217
QL EK+E KL E+ + + +R+ + L E + +V+ + + ++
Sbjct: 516 QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLEN 575
Query: 218 ELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQ 277
EL L+ E + K+L+ +S Q LE + ++ +LE +E+ + QTL +
Sbjct: 576 ELSSKVELLREKEDQIKKLQEYIDS--QKLENIKMDLSYSLESIEDPKQMKQTLFDAE-- 631
Query: 278 PPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSL 337
+ + + L E L +++MKE + +E + + Y SQ +A +
Sbjct: 632 --------TVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683
Query: 338 QELTAEKQQAERELK-----AEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERM 392
+L E Q A E+ + KV DL L E EG + L++ LN +V E+ E +
Sbjct: 684 VDLEKELQSAFNEITKLTSLIDGKVPKDLLCNL-ELEGKITDLQKELNKEV---EENEAL 739
Query: 393 RADV 396
R +V
Sbjct: 740 REEV 743
Score = 57.0 bits (136), Expect = 4e-08
Identities = 82/420 (19%), Positives = 188/420 (44%), Gaps = 39/420 (9%)
Query: 113 NILLAAESEFEQTQWLEMLQESG--KVTWKNAQLGEAMIKSLEAQGLQ-LAKEKQEYLDK 169
N L + SE E ++ L M + +G K ++ +G + LEA+ Q L + ++ ++
Sbjct: 981 NTLKSKISE-EVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKD--NE 1037
Query: 170 LMEETEELCLQREQREELERLNQVLEAEKQQFE-----------EVVQELRMEQEQIKRE 218
++E+ ++ +++ EL+++ + + AEK+Q + E +ELR+ +++K++
Sbjct: 1038 IIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQ 1097
Query: 219 LELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQP 278
E+ A+ +++ EL + L + E+L + ++ E ++ N + ++ ++
Sbjct: 1098 QEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1157
Query: 279 PPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREF-------YSSQSQ 331
L + L+ E ++ + E+L +++ EN E +++ +ER+ + ++
Sbjct: 1158 NEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERD 1217
Query: 332 ALQNSLQELTAEKQQAERELK------AEVKVRMDLERRLREAEGALRSLEQGLNSKVRN 385
L+ ++E+ A Q + ELK E + +D RR + A Q L
Sbjct: 1218 HLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTK 1277
Query: 386 KEKEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSS 445
++E + + L +E E ++ ++ + S RI+ R R +
Sbjct: 1278 LQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIE---MERLRLN 1334
Query: 446 TSWNDMKPSQSFMTSQLDANNMEELKEVAKRLSRDQ---RFRESIYHIMATQPGAPSALS 502
+ + + +T + D N++ +KE A + DQ RE++ I +Q +L+
Sbjct: 1335 EKFQESQEEIKSLTKERD--NLKTIKE-ALEVKHDQLKEHIRETLAKIQESQSKQEQSLN 1391
Score = 52.4 bits (124), Expect = 1e-06
Identities = 64/275 (23%), Positives = 129/275 (46%), Gaps = 26/275 (9%)
Query: 148 MIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQE 207
++ +LE +G + Q+ L+K +EE E L + EL+ L +E +++ ++ +E
Sbjct: 712 LLCNLELEGK--ITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEE 769
Query: 208 LRM---EQEQIKRELELTARCLKGVEQE----KKELRHLTESLQQTLEELSIEKKKTLEM 260
L + E++++ E+ ++G+ +E K +L + + T +E + KTL M
Sbjct: 770 LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQE--FQNFKTLHM 827
Query: 261 ---------LEENENHLQTLANQSEQPPP-SGGLHSNLRQIEEKMQQLLEEKLLAEKRMK 310
LEENE Q + N S++ L + ++ K Q+L E+ ++R+
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLN 887
Query: 311 ENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEG 370
E E+ L+E+ E S Q ++ +T + QQ E+K + + DL++ +
Sbjct: 888 EMEQ----LKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQI 943
Query: 371 ALRSLEQGLNSKVR-NKEKEERMRADVSHLKRFFE 404
L+ ++ V N + +E++R + LK+ E
Sbjct: 944 ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978
Score = 45.1 bits (105), Expect = 2e-04
Identities = 64/282 (22%), Positives = 115/282 (40%), Gaps = 52/282 (18%)
Query: 151 SLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRM 210
SLE + + K++ L +L+EE + LQ+ Q E++E L ++L L +
Sbjct: 363 SLETRAQAMEKDQ---LAQLLEEKD--LLQKVQNEKIENLTRMLVTSSS--------LTL 409
Query: 211 EQEQIKRELELTARCLKGVEQEKKE-----------------------LRHLTESLQQTL 247
+QE + CL + + K LR + ES+
Sbjct: 410 QQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSES 469
Query: 248 EELSIEKKKTLEMLEENE-NHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAE 306
+ S TL+ L E E N L NQ L ++ + +QL EK E
Sbjct: 470 DVFS----NTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEME 525
Query: 307 KRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAE---RELKAEVKVRMDLER 363
++KE + ER+ Q L + + L + AE ++L+ E+ +++L
Sbjct: 526 LKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVEL-- 583
Query: 364 RLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEE 405
LRE E ++ L++ ++S +K E ++ D+S+ E+
Sbjct: 584 -LREKEDQIKKLQEYIDS-----QKLENIKMDLSYSLESIED 619
Score = 29.6 bits (65), Expect = 6.7
Identities = 34/149 (22%), Positives = 61/149 (40%), Gaps = 16/149 (10%)
Query: 208 LRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENH 267
L ++ E I+ E E++ ++Q+ ++L L + LS E K E + E H
Sbjct: 2543 LILKSEHIRLEKEISK-----LKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAH 2597
Query: 268 LQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKEN------EERSRALEE 321
Q S + P G S +QI +E+ L + KE+ + RS++L
Sbjct: 2598 KQVTCENSPKSPKVTGTASKKKQITPSQ---CKERNLQDPVPKESPKSCFFDSRSKSLPS 2654
Query: 322 ER--EFYSSQSQALQNSLQELTAEKQQAE 348
++ + S L +Q AE ++
Sbjct: 2655 PHPVRYFDNSSLGLCPEVQNAGAESVDSQ 2683
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 82.0 bits (201), Expect = 1e-15
Identities = 97/389 (24%), Positives = 177/389 (45%), Gaps = 44/389 (11%)
Query: 130 MLQESGKVTWKNAQLG-EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQ----- 183
M +E V + QL E + +E QL EK + ++L ETE LC + E+
Sbjct: 848 MAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE-LCAEAEELRARL 906
Query: 184 ---REELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVE--QEKKELRH 238
++ELE + LEA ++ EE Q L+ E++++++ ++ L+ E ++K +L
Sbjct: 907 TAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEK 966
Query: 239 LT--------ESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQ 290
+T E Q LE+ + + K ++LE+ T N +E+ S L + L+
Sbjct: 967 VTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT--NLTEEEEKSKSL-AKLKN 1023
Query: 291 IEEKMQQLLEEKL-LAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAER 349
E M LEE+L EK+ +E E+ R LE + S Q LQ + EL + + E
Sbjct: 1024 KHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 350 ELKAEVKVRMDLE--------RRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSH--- 398
EL+A + R++ E +++RE E + L++ L S+ ++ K E+ + D+
Sbjct: 1084 ELQAAL-ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELE 1142
Query: 399 -LKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSF 457
LK E+ + + + ++ + V I K K+ + +M+ S
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKREQEVNILK------KTLEEEAKTHEAQIQEMRQKHSQ 1196
Query: 458 MTSQLDANNMEELKEVAKRLSRDQRFRES 486
+L A +E+ K V L + ++ E+
Sbjct: 1197 AVEEL-AEQLEQTKRVKANLEKAKQTLEN 1224
Score = 76.3 bits (186), Expect = 6e-14
Identities = 65/228 (28%), Positives = 115/228 (50%), Gaps = 24/228 (10%)
Query: 157 LQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIK 216
LQ++++++E +M + EEL RE++ E N++ E E Q + + ++L++ QEQ++
Sbjct: 838 LQVSRQEEE----MMAKEEELVKVREKQLAAE--NRLTEMETLQSQLMAEKLQL-QEQLQ 890
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
E EL A E +ELR + +Q LEE+ + + +E EE HLQ + +
Sbjct: 891 AETELCA--------EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
Q L L + E Q+L EK+ E ++K+ EE LE++ + + + L++
Sbjct: 943 QNIQE--LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000
Query: 337 LQELTAEKQQAERELKAEVKVR-------MDLERRLREAEGALRSLEQ 377
+ E T + E + K+ K++ DLE RLR E + LE+
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Score = 66.2 bits (160), Expect = 6e-11
Identities = 82/296 (27%), Positives = 143/296 (48%), Gaps = 56/296 (18%)
Query: 136 KVTWKNAQLGEA--MIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELE---RL 190
KVT +L ++ +++ +L K+ L+ +++T+EL LQ E R++L +L
Sbjct: 1274 KVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA-LESQLQDTQEL-LQEENRQKLSLSTKL 1331
Query: 191 NQVLEAEKQQFEEVVQELRMEQEQIKRELEL------------------TARCLKGVEQE 232
QV E EK F E ++E +E+ K LE + CL+ E+
Sbjct: 1332 KQV-EDEKNSFREQLEE----EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 233 KKELRHLTESLQQTLEEL-----SIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSN 287
K++L+ E L Q EE +EK KT + +E ++ L L +Q + N
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDKLEKTKT-RLQQELDDLLVDLDHQRQSA-------CN 1438
Query: 288 LRQIEEKMQQLL-EEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQ 346
L + ++K QLL EEK ++ K EER RA E RE +++ +L +L+E +K +
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYA---EERDRAEAEARE-KETKALSLARALEEAMEQKAE 1494
Query: 347 AER-------ELKAEVKVRMDLERRLREAEGALRSLEQGLNS-KVRNKEKEERMRA 394
ER E++ + + D+ + + E E + R+LEQ + K + +E E+ ++A
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQA 1550
Score = 65.1 bits (157), Expect = 1e-10
Identities = 78/322 (24%), Positives = 144/322 (44%), Gaps = 36/322 (11%)
Query: 117 AAESEFEQTQWLEMLQESGKVTWKNAQ---LGEAMIKSLEAQGLQLAKEKQEYLDKLMEE 173
A E +Q ++ ++L E ++ K A+ EA + E + L LA+ L++ ME+
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA----LEEAMEQ 1491
Query: 174 TEEL-CLQREQREELERLNQV----------LEAEKQQFEEVVQELRMEQEQIKRELELT 222
EL L ++ R E+E L LE K+ E+ V+E++ + E+++ EL+ T
Sbjct: 1492 KAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT 1551
Query: 223 ARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTL-EMLEENENHLQTLANQSEQPPPS 281
+E + ++ E Q +E S EKKK L + E E L+ Q +
Sbjct: 1552 EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAA 1611
Query: 282 GGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELT 341
+++E ++ L A K E ++ R L+ + + + + S +E+
Sbjct: 1612 ------RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 342 AEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQ---GLNSKVRNK--------EKEE 390
A+ ++ E++LK+ + L+ L AE A R +Q L ++ N E++
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725
Query: 391 RMRADVSHLKRFFEECIRNAEL 412
R+ A ++ L+ EE N EL
Sbjct: 1726 RLEARIAQLEEELEEEQGNTEL 1747
Score = 56.6 bits (135), Expect = 5e-08
Identities = 73/332 (21%), Positives = 133/332 (40%), Gaps = 42/332 (12%)
Query: 94 KEEPSMPYAMKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLE 153
KEE ++ + N+ L E E + LQE + + E + L
Sbjct: 1081 KEEELQAALARVEEEAAQKNMALKKIRELESQ--ISELQEDLESERASRNKAEKQKRDLG 1138
Query: 154 AQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQ- 212
+ L E ++ LD + E L+ ++ +E+ L + LE E + E +QE+R +
Sbjct: 1139 EELEALKTELEDTLDSTAAQQE---LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195
Query: 213 ----------EQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLE 262
EQ KR + + +E E+ EL + + L Q + ++KK L+
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255
Query: 263 ENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEE 322
E LQ N+ E+ ++ +K+ +L E + +++ +S L ++
Sbjct: 1256 E----LQVKFNEGERV---------RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 323 REFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSK 382
SQ Q Q LQE +K +LK + +L E E A +LE+ + +
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIAT- 1361
Query: 383 VRNKEKEERMRADVSHLKRFFEE---CIRNAE 411
+ A V+ +K+ E+ C+ AE
Sbjct: 1362 ---------LHAQVADMKKKMEDSVGCLETAE 1384
Score = 54.3 bits (129), Expect = 3e-07
Identities = 58/273 (21%), Positives = 121/273 (44%), Gaps = 48/273 (17%)
Query: 142 AQLGEAMIKSLEAQGLQLAKE--------------KQEYLDKLMEETEELCLQREQREEL 187
A+ E +KS+EA+ +QL +E + E D++ + + L E++ L
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 188 E----RLNQVLEAEKQQFEEVVQELR---MEQEQIKRELELTARCLKGVEQEKKELRHLT 240
E +L + LE E+ E + L+ ++ +QI +L L + E +++L
Sbjct: 1728 EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787
Query: 241 ESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLE 300
+ L+ L+E+ K S+ L + + Q+EE++ +
Sbjct: 1788 KELKVKLQEMEGTVK-------------------SKYKASITALEAKIAQLEEQLDNETK 1828
Query: 301 EKLLAEKRMKENEERSR----ALEEER---EFYSSQSQALQNSLQELTAEKQQAERELKA 353
E+ A K+++ E++ + +++ER E Y Q+ L++L + ++AE E +
Sbjct: 1829 ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQR 1888
Query: 354 EVKVRMDLERRLREAEGALRSLEQGLNSKVRNK 386
R L+R L +A ++ + ++S ++NK
Sbjct: 1889 ANASRRKLQRELEDATETADAMNREVSS-LKNK 1920
Score = 37.7 bits (86), Expect = 0.025
Identities = 42/217 (19%), Positives = 95/217 (43%), Gaps = 26/217 (11%)
Query: 294 KMQQLLEEKLLAEKRMKENEERSRALEEE--REFYSSQSQALQNSLQELTAEKQQAEREL 351
K++ LL+ E+ M + EE + E++ E ++ + LQ+ +L AEK Q + +L
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQS---QLMAEKLQLQEQL 889
Query: 352 KAEVKV---RMDLERRLREAEGALRSLEQGLNSKVRNKE--------KEERMRADVSHLK 400
+AE ++ +L RL + L + L ++V +E ++++M+ ++ L+
Sbjct: 890 QAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE 949
Query: 401 RFFEE--------CIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMK 452
EE + EAK+ + + + + + K + R + ++
Sbjct: 950 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 453 PSQSFMTSQLDANNMEE--LKEVAKRLSRDQRFRESI 487
+ S N E + ++ +RL R+++ R+ +
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL 1046
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 82.0 bits (201), Expect = 1e-15
Identities = 80/346 (23%), Positives = 167/346 (48%), Gaps = 40/346 (11%)
Query: 33 GVLWKRPFGRPSAKWSRRFFIIKESFLLYYSESEKKSFETNKYFNIHPKGVIPLGG-CLV 91
G LWKR G W+ R+F ++ S L Y+ E K +G+IPL C V
Sbjct: 221 GYLWKR--GHLRRNWAERWFQLQPSCLCYFGSEECKE----------KRGIIPLDAHCCV 268
Query: 92 E---PKEEPSMPYAMKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAM 148
E ++ + +K +++ + ++A ++ +W +Q + ++ A+ ++
Sbjct: 269 EVLPDRDGKRCMFCVKTANRTYE----MSASDTRQRQEWTAAIQMAIRL---QAEGKTSL 321
Query: 149 IKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQ-REELERLNQVLEAEKQQFEEVVQE 207
K L+ Q +E++E ++ EE L+ +Q +EE ER Q LE ++ + +
Sbjct: 322 HKDLK----QKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERL 377
Query: 208 LRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENH 267
L+ E+E+ + + + L+G +E ++ R ++ + EE + +++ ++ LEE +
Sbjct: 378 LQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQR 437
Query: 268 LQT---LANQSEQPPPSGGLHSN--LRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEE 322
LQ L ++ + S + L + EEK++QL++ K E+ ++ ++ L++E
Sbjct: 438 LQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQE 497
Query: 323 REFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREA 368
S Q Q L+E+ +Q+A+ +++A +R+LR+A
Sbjct: 498 MAQQSRSLQQAQQQLEEVRQNRQRADEDVEA-------AQRKLRQA 536
Score = 53.1 bits (126), Expect = 6e-07
Identities = 56/222 (25%), Positives = 98/222 (44%), Gaps = 28/222 (12%)
Query: 210 MEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQ 269
M ++ E TA + + + L + L+Q E ++++ EE LQ
Sbjct: 292 MSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQ 351
Query: 270 TLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQ 329
L + E R+++E ++ L E + AE+ ++E EER R+ E +
Sbjct: 352 QLQEEKE------------RKLQE-LELLQEAQRQAERLLQEEEERRRSQHRELQ----- 393
Query: 330 SQALQNSLQELTAEK--QQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKE 387
QAL+ L+E + QAE ELK E R +R++E E + L++ L +V+ +
Sbjct: 394 -QALEGQLREAEQARASMQAEMELKEEEAARQ--RQRIKELEEMQQRLQEALQLEVKARR 450
Query: 388 KEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKA 429
EE +R + L EE +L+ M + + YI +A
Sbjct: 451 DEESVRIAQTRLLEEEEE-----KLKQLMQLKEEQERYIERA 487
Score = 37.4 bits (85), Expect = 0.032
Identities = 43/185 (23%), Positives = 82/185 (44%), Gaps = 18/185 (9%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETE 175
+ AE E ++ + Q ++ +L EA+ LE + + + + +L+EE E
Sbjct: 410 MQAEMELKEEEAARQRQRIKELEEMQQRLQEAL--QLEVKARRDEESVRIAQTRLLEEEE 467
Query: 176 ELCLQREQ-REELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKK 234
E Q Q +EE ER + + EK +EL+ E Q R L+ + L+ V Q ++
Sbjct: 468 EKLKQLMQLKEEQERYIERAQQEK-------EELQQEMAQQSRSLQQAQQQLEEVRQNRQ 520
Query: 235 ELRHLTESLQQTLEELS-------IEKKKTLEMLEENENHLQTLANQSE-QPPPSGGLHS 286
E+ Q+ L + S ++ + + +E + T ++ S QPP S
Sbjct: 521 RADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDS 580
Query: 287 NLRQI 291
+L+++
Sbjct: 581 SLKRL 585
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 80.1 bits (196), Expect = 4e-15
Identities = 86/345 (24%), Positives = 159/345 (46%), Gaps = 50/345 (14%)
Query: 124 QTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQ 183
Q + ++ ++ + T + Q E +K LE + QL +EK ++L ETE
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA----- 904
Query: 184 REELERLNQVLEAEKQQFEEVVQEL--RMEQE-----QIKRELELTARCLKGVEQEKKEL 236
E E + L A+KQ+ EE++ E+ R+E+E Q++ E + A+ + +E++ +E
Sbjct: 905 --EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 237 RHLTESLQQTLEELSIEKK-------------------KTLEMLEENENHLQTLANQSEQ 277
+ LQ LE+++ E K K ++LEE + L T N +E+
Sbjct: 963 EAARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT--NLAEE 1018
Query: 278 PPPSGGLHSNLRQIEEKMQQLLEEKL-LAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
+ L + L+ E M LE +L EK +E E+ R LE + + Q LQ
Sbjct: 1019 EEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 337 LQELTAEKQQAERELKA-------EVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKE 389
+ EL + + E EL+A E+ + + +++RE EG + L++ L+S+ + K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 390 ERMRADVSH----LKRFFEECIRNAELEAKMPVIMKNSVYIHKAA 430
E+ + D+ LK E+ + + + ++ + V + K A
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Score = 74.7 bits (182), Expect = 2e-13
Identities = 81/281 (28%), Positives = 138/281 (49%), Gaps = 52/281 (18%)
Query: 148 MIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREEL-----------------ERL 190
M+ E + ++LAK+ L +++T+EL LQ E R++L ++L
Sbjct: 1295 MLNEAEGKAIKLAKDVAS-LSSQLQDTQEL-LQEETRQKLNVSTKLRQLEEERNSLQDQL 1352
Query: 191 NQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEEL 250
++ +EA KQ E + L ++ K++L+ A ++ +E+ KK + E+L Q EE
Sbjct: 1353 DEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE- 1410
Query: 251 SIEKKKTLEMLEENENHLQT--------LANQSEQPPPSGGLHSNLRQIEEKMQQLL-EE 301
K + LE+ +N LQ L NQ + L SNL + + K QLL EE
Sbjct: 1411 ---KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ-------LVSNLEKKQRKFDQLLAEE 1460
Query: 302 KLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERE---LKAE---- 354
K ++ K +ER RA E RE +++ +L +L+E K++ ER LKAE
Sbjct: 1461 KNISSKYA---DERDRAEAEARE-KETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Query: 355 VKVRMDLERRLREAEGALRSLEQGLNS-KVRNKEKEERMRA 394
V + D+ + + E E + R+LE + K + +E E+ ++A
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Score = 72.8 bits (177), Expect = 7e-13
Identities = 63/248 (25%), Positives = 119/248 (47%), Gaps = 31/248 (12%)
Query: 157 LQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIK 216
LQ+ ++++E + + +EL +E++++ E N++ E E Q+ ++ +E + QEQ++
Sbjct: 845 LQVTRQEEE----MQAKEDELQKTKERQQKAE--NELKELE-QKHSQLTEEKNLLQEQLQ 897
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
E EL A E +E+R + +Q LEE+ E + LE EE + Q A + +
Sbjct: 898 AETELYA--------EAEEMRVRLAAKKQELEEILHEMEARLE--EEEDRGQQLQAERKK 947
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
L L + E Q+L EK+ AE ++K+ E+ ++++ S + + L+
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 337 LQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADV 396
+ +LT + E + K K++ E + E E L+ KEE+ R ++
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK--------------KEEKSRQEL 1053
Query: 397 SHLKRFFE 404
LKR E
Sbjct: 1054 EKLKRKLE 1061
Score = 67.0 bits (162), Expect = 4e-11
Identities = 79/330 (23%), Positives = 146/330 (44%), Gaps = 60/330 (18%)
Query: 115 LLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGL-------QLAKEKQEYL 167
+L E + E+ + + KVT EA IK LE + L +L+KE++
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVT------AEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 168 DKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRM---EQEQIKRELELTAR 224
+++ + T L + E+ + L +L K + E ++ EL + ++E+ ++ELE R
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKL-------KNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 225 CLKG---------------VEQEKKELRHLTESLQQTLEELSIE---KKKTLEMLEENEN 266
L+G + + K +L E LQ L L E K L+ + E E
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 267 HLQTLA----------NQSEQPPPSGG--LHSNLRQIEEKMQQLLEEKLLAEKRMKENEE 314
H+ L N++E+ G L + ++E+ + ++ L KR +E
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 315 RSRALEEEREFYSSQSQALQN----SLQELTAEKQQAERELKAEVKVRMDLERRLREAEG 370
+AL+EE + +Q Q ++ +++ELT + +Q +R K + LE+ + G
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 371 ALRSLEQGLNSKVRNKEKEERMRADVSHLK 400
LR L Q +K + K++++ A V L+
Sbjct: 1239 ELRVLGQ---AKQEVEHKKKKLEAQVQELQ 1265
Score = 65.5 bits (158), Expect = 1e-10
Identities = 72/315 (22%), Positives = 130/315 (41%), Gaps = 23/315 (7%)
Query: 116 LAAESEFEQTQWL-----EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLD-- 168
L A+ E E+T + E L S KN E ++LE Q ++ + +E D
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555
Query: 169 ------KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELT 222
KL E L+ + +L+ ++ E +++Q + + E E E +++ L
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615
Query: 223 ARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTL-ANQSEQPPPS 281
A K +E + K+L +S + EE + +K +++ + L+ A++ E +
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 282 GGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELT 341
+ +E + QL E+ AE+ K+ + L EE S ALQ+ + L
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 342 AEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKR 401
A Q E EL+ E + R+R+A L L ++ +K E R +
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER--- 1792
Query: 402 FFEECIRNAELEAKM 416
+N EL +K+
Sbjct: 1793 ------QNKELRSKL 1801
Score = 65.5 bits (158), Expect = 1e-10
Identities = 71/272 (26%), Positives = 123/272 (45%), Gaps = 27/272 (9%)
Query: 128 LEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKE--------KQEYLDKLMEETEELCL 179
LE + S + A+ E KSLEA +QL ++ KQ L+K E EEL
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-EELAEELAS 1719
Query: 180 QREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKEL--- 236
R L+ + LEA Q EE EL EQ ++ + + + EQ EL
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEE---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 237 RHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQ 296
R + + ++L + K+ L E E A +S+ L + + Q+EE+++
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEG-----AVKSKFKSTIAALEAKIAQLEEQVE 1831
Query: 297 QLLEEKLLAEKRMKENEERSRAL----EEER---EFYSSQSQALQNSLQELTAEKQQAER 349
Q EK A K +K+ +++ + + E+ER E Y Q++ +++L + ++AE
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891
Query: 350 ELKAEVKVRMDLERRLREAEGALRSLEQGLNS 381
E + R L+R L EA + ++ + +N+
Sbjct: 1892 ESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Score = 58.2 bits (139), Expect = 2e-08
Identities = 79/347 (22%), Positives = 143/347 (41%), Gaps = 73/347 (21%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQ---LGEAMIKSLEAQGLQLAKEKQEYLDKLME 172
L + E +Q ++ ++L E ++ K A EA + E + L LA+ +E L
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----- 1496
Query: 173 ETEELCLQREQREELERLNQVLEAEKQ--------------QFEEVVQELRMEQEQIKRE 218
E +EELER N++L+AE + + E+ + L + E++K +
Sbjct: 1497 ---------EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 219 LELTARCLKGVEQEKKELRHLTESLQ-------QTLEELSIEKKKTLE-MLEENENHLQT 270
LE L+ E K L ++L+ Q +E + EK++ L+ L E E L+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 271 LANQ-----SEQPPPSGGL-------HSNLRQIEEKMQQLLEEKLLAEKR---------- 308
Q + + G L S ++ EE ++QL KL A+ +
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL--RKLQAQMKDFQRELEDAR 1665
Query: 309 ---------MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRM 359
KENE+++++LE + A + + ++ EK++ EL + + R
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725
Query: 360 DLERRLREAEGALRSLEQGLNSKVRNKE-KEERMRADVSHLKRFFEE 405
L+ R E + LE+ L + N E +R+R ++ E
Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Score = 56.2 bits (134), Expect = 7e-08
Identities = 55/230 (23%), Positives = 104/230 (45%), Gaps = 10/230 (4%)
Query: 156 GLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQ--- 212
G +L K E D L + L+ ++ +E+ L + L+ E + E VQE+R +
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 213 -EQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTL 271
E++ +LE R +++ K+ L L L L K++ ++ E +Q L
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 272 ANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQ 331
++ S G + ++ +K+ +L E + E E ++ L ++ SSQ Q
Sbjct: 1265 QSKC-----SDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 332 ALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNS 381
Q LQE T +K +L+ + R L+ +L E A ++LE+ +++
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Score = 55.5 bits (132), Expect = 1e-07
Identities = 62/281 (22%), Positives = 119/281 (42%), Gaps = 36/281 (12%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLME----------ETEELCLQREQ----REELERLN 191
E +K LE Q K ++E + +L + E E+ R++ +E E+
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1682
Query: 192 QVLEAEKQQFEEVV-------QELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQ 244
+ LEA+ Q +E + ++ +E+E++ EL + ++ EK+ L L+
Sbjct: 1683 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE 1742
Query: 245 QTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLL 304
+ LEE + + + + + L+N+ + + + RQ E+ + L KL
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL- 1801
Query: 305 AEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERR 364
E A++ + + S AL+ + +L + +Q RE +A K +++
Sbjct: 1802 --------HEMEGAVKSK---FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 365 LREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEE 405
L+E L +E + KE+ E+ A V LKR EE
Sbjct: 1851 LKE---ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Score = 34.7 bits (78), Expect = 0.21
Identities = 30/111 (27%), Positives = 54/111 (48%), Gaps = 3/111 (2%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVV 205
EA I LE Q Q A+EKQ L ++ ++L +E ++E ++ E K+Q E+
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKL---KEILLQVEDERKMAEQYKEQAEKGN 1876
Query: 206 QELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKK 256
++ + Q++ E + R + ++EL TES + E++ K K
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 80.1 bits (196), Expect = 4e-15
Identities = 86/345 (24%), Positives = 159/345 (46%), Gaps = 50/345 (14%)
Query: 124 QTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQ 183
Q + ++ ++ + T + Q E +K LE + QL +EK ++L ETE
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA----- 911
Query: 184 REELERLNQVLEAEKQQFEEVVQEL--RMEQE-----QIKRELELTARCLKGVEQEKKEL 236
E E + L A+KQ+ EE++ E+ R+E+E Q++ E + A+ + +E++ +E
Sbjct: 912 --EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 237 RHLTESLQQTLEELSIEKK-------------------KTLEMLEENENHLQTLANQSEQ 277
+ LQ LE+++ E K K ++LEE + L T N +E+
Sbjct: 970 EAARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT--NLAEE 1025
Query: 278 PPPSGGLHSNLRQIEEKMQQLLEEKL-LAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
+ L + L+ E M LE +L EK +E E+ R LE + + Q LQ
Sbjct: 1026 EEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 337 LQELTAEKQQAERELKA-------EVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKE 389
+ EL + + E EL+A E+ + + +++RE EG + L++ L+S+ + K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 390 ERMRADVSH----LKRFFEECIRNAELEAKMPVIMKNSVYIHKAA 430
E+ + D+ LK E+ + + + ++ + V + K A
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Score = 74.7 bits (182), Expect = 2e-13
Identities = 81/281 (28%), Positives = 138/281 (49%), Gaps = 52/281 (18%)
Query: 148 MIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREEL-----------------ERL 190
M+ E + ++LAK+ L +++T+EL LQ E R++L ++L
Sbjct: 1302 MLNEAEGKAIKLAKDVAS-LSSQLQDTQEL-LQEETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 191 NQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEEL 250
++ +EA KQ E + L ++ K++L+ A ++ +E+ KK + E+L Q EE
Sbjct: 1360 DEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE- 1417
Query: 251 SIEKKKTLEMLEENENHLQT--------LANQSEQPPPSGGLHSNLRQIEEKMQQLL-EE 301
K + LE+ +N LQ L NQ + L SNL + + K QLL EE
Sbjct: 1418 ---KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ-------LVSNLEKKQRKFDQLLAEE 1467
Query: 302 KLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERE---LKAE---- 354
K ++ K +ER RA E RE +++ +L +L+E K++ ER LKAE
Sbjct: 1468 KNISSKYA---DERDRAEAEARE-KETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Query: 355 VKVRMDLERRLREAEGALRSLEQGLNS-KVRNKEKEERMRA 394
V + D+ + + E E + R+LE + K + +E E+ ++A
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Score = 72.8 bits (177), Expect = 7e-13
Identities = 63/248 (25%), Positives = 119/248 (47%), Gaps = 31/248 (12%)
Query: 157 LQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIK 216
LQ+ ++++E + + +EL +E++++ E N++ E E Q+ ++ +E + QEQ++
Sbjct: 852 LQVTRQEEE----MQAKEDELQKTKERQQKAE--NELKELE-QKHSQLTEEKNLLQEQLQ 904
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
E EL A E +E+R + +Q LEE+ E + LE EE + Q A + +
Sbjct: 905 AETELYA--------EAEEMRVRLAAKKQELEEILHEMEARLE--EEEDRGQQLQAERKK 954
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
L L + E Q+L EK+ AE ++K+ E+ ++++ S + + L+
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 337 LQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADV 396
+ +LT + E + K K++ E + E E L+ KEE+ R ++
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK--------------KEEKSRQEL 1060
Query: 397 SHLKRFFE 404
LKR E
Sbjct: 1061 EKLKRKLE 1068
Score = 67.0 bits (162), Expect = 4e-11
Identities = 79/330 (23%), Positives = 146/330 (44%), Gaps = 60/330 (18%)
Query: 115 LLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGL-------QLAKEKQEYL 167
+L E + E+ + + KVT EA IK LE + L +L+KE++
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVT------AEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 168 DKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRM---EQEQIKRELELTAR 224
+++ + T L + E+ + L +L K + E ++ EL + ++E+ ++ELE R
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKL-------KNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 225 CLKG---------------VEQEKKELRHLTESLQQTLEELSIE---KKKTLEMLEENEN 266
L+G + + K +L E LQ L L E K L+ + E E
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 267 HLQTLA----------NQSEQPPPSGG--LHSNLRQIEEKMQQLLEEKLLAEKRMKENEE 314
H+ L N++E+ G L + ++E+ + ++ L KR +E
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 315 RSRALEEEREFYSSQSQALQN----SLQELTAEKQQAERELKAEVKVRMDLERRLREAEG 370
+AL+EE + +Q Q ++ +++ELT + +Q +R K + LE+ + G
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 371 ALRSLEQGLNSKVRNKEKEERMRADVSHLK 400
LR L Q +K + K++++ A V L+
Sbjct: 1246 ELRVLGQ---AKQEVEHKKKKLEAQVQELQ 1272
Score = 65.5 bits (158), Expect = 1e-10
Identities = 72/315 (22%), Positives = 130/315 (41%), Gaps = 23/315 (7%)
Query: 116 LAAESEFEQTQWL-----EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLD-- 168
L A+ E E+T + E L S KN E ++LE Q ++ + +E D
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562
Query: 169 ------KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELT 222
KL E L+ + +L+ ++ E +++Q + + E E E +++ L
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622
Query: 223 ARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTL-ANQSEQPPPS 281
A K +E + K+L +S + EE + +K +++ + L+ A++ E +
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 282 GGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELT 341
+ +E + QL E+ AE+ K+ + L EE S ALQ+ + L
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 342 AEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKR 401
A Q E EL+ E + R+R+A L L ++ +K E R +
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER--- 1799
Query: 402 FFEECIRNAELEAKM 416
+N EL +K+
Sbjct: 1800 ------QNKELRSKL 1808
Score = 65.5 bits (158), Expect = 1e-10
Identities = 71/272 (26%), Positives = 123/272 (45%), Gaps = 27/272 (9%)
Query: 128 LEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKE--------KQEYLDKLMEETEELCL 179
LE + S + A+ E KSLEA +QL ++ KQ L+K E EEL
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-EELAEELAS 1726
Query: 180 QREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKEL--- 236
R L+ + LEA Q EE EL EQ ++ + + + EQ EL
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEE---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 237 RHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQ 296
R + + ++L + K+ L E E A +S+ L + + Q+EE+++
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEG-----AVKSKFKSTIAALEAKIAQLEEQVE 1838
Query: 297 QLLEEKLLAEKRMKENEERSRAL----EEER---EFYSSQSQALQNSLQELTAEKQQAER 349
Q EK A K +K+ +++ + + E+ER E Y Q++ +++L + ++AE
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898
Query: 350 ELKAEVKVRMDLERRLREAEGALRSLEQGLNS 381
E + R L+R L EA + ++ + +N+
Sbjct: 1899 ESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Score = 58.2 bits (139), Expect = 2e-08
Identities = 79/347 (22%), Positives = 143/347 (41%), Gaps = 73/347 (21%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQ---LGEAMIKSLEAQGLQLAKEKQEYLDKLME 172
L + E +Q ++ ++L E ++ K A EA + E + L LA+ +E L
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----- 1503
Query: 173 ETEELCLQREQREELERLNQVLEAEKQ--------------QFEEVVQELRMEQEQIKRE 218
E +EELER N++L+AE + + E+ + L + E++K +
Sbjct: 1504 ---------EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 219 LELTARCLKGVEQEKKELRHLTESLQ-------QTLEELSIEKKKTLE-MLEENENHLQT 270
LE L+ E K L ++L+ Q +E + EK++ L+ L E E L+
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 271 LANQ-----SEQPPPSGGL-------HSNLRQIEEKMQQLLEEKLLAEKR---------- 308
Q + + G L S ++ EE ++QL KL A+ +
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL--RKLQAQMKDFQRELEDAR 1672
Query: 309 ---------MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRM 359
KENE+++++LE + A + + ++ EK++ EL + + R
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732
Query: 360 DLERRLREAEGALRSLEQGLNSKVRNKE-KEERMRADVSHLKRFFEE 405
L+ R E + LE+ L + N E +R+R ++ E
Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Score = 56.2 bits (134), Expect = 7e-08
Identities = 55/230 (23%), Positives = 104/230 (45%), Gaps = 10/230 (4%)
Query: 156 GLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQ--- 212
G +L K E D L + L+ ++ +E+ L + L+ E + E VQE+R +
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 213 -EQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTL 271
E++ +LE R +++ K+ L L L L K++ ++ E +Q L
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 272 ANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQ 331
++ S G + ++ +K+ +L E + E E ++ L ++ SSQ Q
Sbjct: 1272 QSKC-----SDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 332 ALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNS 381
Q LQE T +K +L+ + R L+ +L E A ++LE+ +++
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Score = 55.5 bits (132), Expect = 1e-07
Identities = 62/281 (22%), Positives = 119/281 (42%), Gaps = 36/281 (12%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLME----------ETEELCLQREQ----REELERLN 191
E +K LE Q K ++E + +L + E E+ R++ +E E+
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1689
Query: 192 QVLEAEKQQFEEVV-------QELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQ 244
+ LEA+ Q +E + ++ +E+E++ EL + ++ EK+ L L+
Sbjct: 1690 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE 1749
Query: 245 QTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLL 304
+ LEE + + + + + L+N+ + + + RQ E+ + L KL
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL- 1808
Query: 305 AEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERR 364
E A++ + + S AL+ + +L + +Q RE +A K +++
Sbjct: 1809 --------HEMEGAVKSK---FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 365 LREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEE 405
L+E L +E + KE+ E+ A V LKR EE
Sbjct: 1858 LKE---ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Score = 34.7 bits (78), Expect = 0.21
Identities = 30/111 (27%), Positives = 54/111 (48%), Gaps = 3/111 (2%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVV 205
EA I LE Q Q A+EKQ L ++ ++L +E ++E ++ E K+Q E+
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKL---KEILLQVEDERKMAEQYKEQAEKGN 1883
Query: 206 QELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKK 256
++ + Q++ E + R + ++EL TES + E++ K K
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 80.1 bits (196), Expect = 4e-15
Identities = 86/345 (24%), Positives = 159/345 (46%), Gaps = 50/345 (14%)
Query: 124 QTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQ 183
Q + ++ ++ + T + Q E +K LE + QL +EK ++L ETE
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA----- 911
Query: 184 REELERLNQVLEAEKQQFEEVVQEL--RMEQE-----QIKRELELTARCLKGVEQEKKEL 236
E E + L A+KQ+ EE++ E+ R+E+E Q++ E + A+ + +E++ +E
Sbjct: 912 --EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 237 RHLTESLQQTLEELSIEKK-------------------KTLEMLEENENHLQTLANQSEQ 277
+ LQ LE+++ E K K ++LEE + L T N +E+
Sbjct: 970 EAARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT--NLAEE 1025
Query: 278 PPPSGGLHSNLRQIEEKMQQLLEEKL-LAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
+ L + L+ E M LE +L EK +E E+ R LE + + Q LQ
Sbjct: 1026 EEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 337 LQELTAEKQQAERELKA-------EVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKE 389
+ EL + + E EL+A E+ + + +++RE EG + L++ L+S+ + K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 390 ERMRADVSH----LKRFFEECIRNAELEAKMPVIMKNSVYIHKAA 430
E+ + D+ LK E+ + + + ++ + V + K A
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Score = 74.7 bits (182), Expect = 2e-13
Identities = 81/281 (28%), Positives = 138/281 (49%), Gaps = 52/281 (18%)
Query: 148 MIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREEL-----------------ERL 190
M+ E + ++LAK+ L +++T+EL LQ E R++L ++L
Sbjct: 1302 MLNEAEGKAIKLAKDVAS-LSSQLQDTQEL-LQEETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 191 NQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEEL 250
++ +EA KQ E + L ++ K++L+ A ++ +E+ KK + E+L Q EE
Sbjct: 1360 DEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE- 1417
Query: 251 SIEKKKTLEMLEENENHLQT--------LANQSEQPPPSGGLHSNLRQIEEKMQQLL-EE 301
K + LE+ +N LQ L NQ + L SNL + + K QLL EE
Sbjct: 1418 ---KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ-------LVSNLEKKQRKFDQLLAEE 1467
Query: 302 KLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERE---LKAE---- 354
K ++ K +ER RA E RE +++ +L +L+E K++ ER LKAE
Sbjct: 1468 KNISSKYA---DERDRAEAEARE-KETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Query: 355 VKVRMDLERRLREAEGALRSLEQGLNS-KVRNKEKEERMRA 394
V + D+ + + E E + R+LE + K + +E E+ ++A
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Score = 72.8 bits (177), Expect = 7e-13
Identities = 63/248 (25%), Positives = 119/248 (47%), Gaps = 31/248 (12%)
Query: 157 LQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIK 216
LQ+ ++++E + + +EL +E++++ E N++ E E Q+ ++ +E + QEQ++
Sbjct: 852 LQVTRQEEE----MQAKEDELQKTKERQQKAE--NELKELE-QKHSQLTEEKNLLQEQLQ 904
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
E EL A E +E+R + +Q LEE+ E + LE EE + Q A + +
Sbjct: 905 AETELYA--------EAEEMRVRLAAKKQELEEILHEMEARLE--EEEDRGQQLQAERKK 954
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
L L + E Q+L EK+ AE ++K+ E+ ++++ S + + L+
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 337 LQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADV 396
+ +LT + E + K K++ E + E E L+ KEE+ R ++
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK--------------KEEKSRQEL 1060
Query: 397 SHLKRFFE 404
LKR E
Sbjct: 1061 EKLKRKLE 1068
Score = 67.0 bits (162), Expect = 4e-11
Identities = 79/330 (23%), Positives = 146/330 (44%), Gaps = 60/330 (18%)
Query: 115 LLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGL-------QLAKEKQEYL 167
+L E + E+ + + KVT EA IK LE + L +L+KE++
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVT------AEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 168 DKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRM---EQEQIKRELELTAR 224
+++ + T L + E+ + L +L K + E ++ EL + ++E+ ++ELE R
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKL-------KNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 225 CLKG---------------VEQEKKELRHLTESLQQTLEELSIE---KKKTLEMLEENEN 266
L+G + + K +L E LQ L L E K L+ + E E
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 267 HLQTLA----------NQSEQPPPSGG--LHSNLRQIEEKMQQLLEEKLLAEKRMKENEE 314
H+ L N++E+ G L + ++E+ + ++ L KR +E
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 315 RSRALEEEREFYSSQSQALQN----SLQELTAEKQQAERELKAEVKVRMDLERRLREAEG 370
+AL+EE + +Q Q ++ +++ELT + +Q +R K + LE+ + G
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 371 ALRSLEQGLNSKVRNKEKEERMRADVSHLK 400
LR L Q +K + K++++ A V L+
Sbjct: 1246 ELRVLGQ---AKQEVEHKKKKLEAQVQELQ 1272
Score = 67.0 bits (162), Expect = 4e-11
Identities = 75/284 (26%), Positives = 128/284 (45%), Gaps = 30/284 (10%)
Query: 128 LEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKE--------KQEYLDKLMEETEELCL 179
LE + S + A+ E KSLEA +QL ++ KQ L+K E EEL
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-EELAEELAS 1726
Query: 180 QREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKEL--- 236
R L+ + LEA Q EE EL EQ ++ + + + EQ EL
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEE---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 237 RHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQ 296
R + + ++L + K+ L E E A +S+ L + + Q+EE+++
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEG-----AVKSKFKSTIAALEAKIAQLEEQVE 1838
Query: 297 QLLEEKLLAEKRMKENEERSRAL----EEER---EFYSSQSQALQNSLQELTAEKQQAER 349
Q EK A K +K+ +++ + + E+ER E Y Q++ +++L + ++AE
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898
Query: 350 ELKAEVKVRMDLERRLREAEGALRSLEQGLN---SKVRNKEKEE 390
E + R L+R L EA + ++ + +N SK+R +E
Sbjct: 1899 ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQE 1942
Score = 65.5 bits (158), Expect = 1e-10
Identities = 72/315 (22%), Positives = 130/315 (41%), Gaps = 23/315 (7%)
Query: 116 LAAESEFEQTQWL-----EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLD-- 168
L A+ E E+T + E L S KN E ++LE Q ++ + +E D
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562
Query: 169 ------KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELT 222
KL E L+ + +L+ ++ E +++Q + + E E E +++ L
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622
Query: 223 ARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTL-ANQSEQPPPS 281
A K +E + K+L +S + EE + +K +++ + L+ A++ E +
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 282 GGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELT 341
+ +E + QL E+ AE+ K+ + L EE S ALQ+ + L
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 342 AEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKR 401
A Q E EL+ E + R+R+A L L ++ +K E R +
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER--- 1799
Query: 402 FFEECIRNAELEAKM 416
+N EL +K+
Sbjct: 1800 ------QNKELRSKL 1808
Score = 58.2 bits (139), Expect = 2e-08
Identities = 79/347 (22%), Positives = 143/347 (41%), Gaps = 73/347 (21%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQ---LGEAMIKSLEAQGLQLAKEKQEYLDKLME 172
L + E +Q ++ ++L E ++ K A EA + E + L LA+ +E L
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----- 1503
Query: 173 ETEELCLQREQREELERLNQVLEAEKQ--------------QFEEVVQELRMEQEQIKRE 218
E +EELER N++L+AE + + E+ + L + E++K +
Sbjct: 1504 ---------EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 219 LELTARCLKGVEQEKKELRHLTESLQ-------QTLEELSIEKKKTLE-MLEENENHLQT 270
LE L+ E K L ++L+ Q +E + EK++ L+ L E E L+
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 271 LANQ-----SEQPPPSGGL-------HSNLRQIEEKMQQLLEEKLLAEKR---------- 308
Q + + G L S ++ EE ++QL KL A+ +
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL--RKLQAQMKDFQRELEDAR 1672
Query: 309 ---------MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRM 359
KENE+++++LE + A + + ++ EK++ EL + + R
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732
Query: 360 DLERRLREAEGALRSLEQGLNSKVRNKE-KEERMRADVSHLKRFFEE 405
L+ R E + LE+ L + N E +R+R ++ E
Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Score = 56.2 bits (134), Expect = 7e-08
Identities = 55/230 (23%), Positives = 104/230 (45%), Gaps = 10/230 (4%)
Query: 156 GLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQ--- 212
G +L K E D L + L+ ++ +E+ L + L+ E + E VQE+R +
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 213 -EQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTL 271
E++ +LE R +++ K+ L L L L K++ ++ E +Q L
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 272 ANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQ 331
++ S G + ++ +K+ +L E + E E ++ L ++ SSQ Q
Sbjct: 1272 QSKC-----SDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 332 ALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNS 381
Q LQE T +K +L+ + R L+ +L E A ++LE+ +++
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 80.1 bits (196), Expect = 4e-15
Identities = 86/345 (24%), Positives = 159/345 (46%), Gaps = 50/345 (14%)
Query: 124 QTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQ 183
Q + ++ ++ + T + Q E +K LE + QL +EK ++L ETE
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA----- 904
Query: 184 REELERLNQVLEAEKQQFEEVVQEL--RMEQE-----QIKRELELTARCLKGVEQEKKEL 236
E E + L A+KQ+ EE++ E+ R+E+E Q++ E + A+ + +E++ +E
Sbjct: 905 --EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 237 RHLTESLQQTLEELSIEKK-------------------KTLEMLEENENHLQTLANQSEQ 277
+ LQ LE+++ E K K ++LEE + L T N +E+
Sbjct: 963 EAARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT--NLAEE 1018
Query: 278 PPPSGGLHSNLRQIEEKMQQLLEEKL-LAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
+ L + L+ E M LE +L EK +E E+ R LE + + Q LQ
Sbjct: 1019 EEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 337 LQELTAEKQQAERELKA-------EVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKE 389
+ EL + + E EL+A E+ + + +++RE EG + L++ L+S+ + K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 390 ERMRADVSH----LKRFFEECIRNAELEAKMPVIMKNSVYIHKAA 430
E+ + D+ LK E+ + + + ++ + V + K A
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Score = 74.7 bits (182), Expect = 2e-13
Identities = 81/281 (28%), Positives = 138/281 (49%), Gaps = 52/281 (18%)
Query: 148 MIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREEL-----------------ERL 190
M+ E + ++LAK+ L +++T+EL LQ E R++L ++L
Sbjct: 1295 MLNEAEGKAIKLAKDVAS-LSSQLQDTQEL-LQEETRQKLNVSTKLRQLEEERNSLQDQL 1352
Query: 191 NQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEEL 250
++ +EA KQ E + L ++ K++L+ A ++ +E+ KK + E+L Q EE
Sbjct: 1353 DEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE- 1410
Query: 251 SIEKKKTLEMLEENENHLQT--------LANQSEQPPPSGGLHSNLRQIEEKMQQLL-EE 301
K + LE+ +N LQ L NQ + L SNL + + K QLL EE
Sbjct: 1411 ---KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ-------LVSNLEKKQRKFDQLLAEE 1460
Query: 302 KLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERE---LKAE---- 354
K ++ K +ER RA E RE +++ +L +L+E K++ ER LKAE
Sbjct: 1461 KNISSKYA---DERDRAEAEARE-KETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Query: 355 VKVRMDLERRLREAEGALRSLEQGLNS-KVRNKEKEERMRA 394
V + D+ + + E E + R+LE + K + +E E+ ++A
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Score = 72.8 bits (177), Expect = 7e-13
Identities = 63/248 (25%), Positives = 119/248 (47%), Gaps = 31/248 (12%)
Query: 157 LQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIK 216
LQ+ ++++E + + +EL +E++++ E N++ E E Q+ ++ +E + QEQ++
Sbjct: 845 LQVTRQEEE----MQAKEDELQKTKERQQKAE--NELKELE-QKHSQLTEEKNLLQEQLQ 897
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
E EL A E +E+R + +Q LEE+ E + LE EE + Q A + +
Sbjct: 898 AETELYA--------EAEEMRVRLAAKKQELEEILHEMEARLE--EEEDRGQQLQAERKK 947
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
L L + E Q+L EK+ AE ++K+ E+ ++++ S + + L+
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 337 LQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADV 396
+ +LT + E + K K++ E + E E L+ KEE+ R ++
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK--------------KEEKSRQEL 1053
Query: 397 SHLKRFFE 404
LKR E
Sbjct: 1054 EKLKRKLE 1061
Score = 67.0 bits (162), Expect = 4e-11
Identities = 79/330 (23%), Positives = 146/330 (44%), Gaps = 60/330 (18%)
Query: 115 LLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGL-------QLAKEKQEYL 167
+L E + E+ + + KVT EA IK LE + L +L+KE++
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVT------AEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 168 DKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRM---EQEQIKRELELTAR 224
+++ + T L + E+ + L +L K + E ++ EL + ++E+ ++ELE R
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKL-------KNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 225 CLKG---------------VEQEKKELRHLTESLQQTLEELSIE---KKKTLEMLEENEN 266
L+G + + K +L E LQ L L E K L+ + E E
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 267 HLQTLA----------NQSEQPPPSGG--LHSNLRQIEEKMQQLLEEKLLAEKRMKENEE 314
H+ L N++E+ G L + ++E+ + ++ L KR +E
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 315 RSRALEEEREFYSSQSQALQN----SLQELTAEKQQAERELKAEVKVRMDLERRLREAEG 370
+AL+EE + +Q Q ++ +++ELT + +Q +R K + LE+ + G
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 371 ALRSLEQGLNSKVRNKEKEERMRADVSHLK 400
LR L Q +K + K++++ A V L+
Sbjct: 1239 ELRVLGQ---AKQEVEHKKKKLEAQVQELQ 1265
Score = 67.0 bits (162), Expect = 4e-11
Identities = 75/284 (26%), Positives = 128/284 (45%), Gaps = 30/284 (10%)
Query: 128 LEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKE--------KQEYLDKLMEETEELCL 179
LE + S + A+ E KSLEA +QL ++ KQ L+K E EEL
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-EELAEELAS 1719
Query: 180 QREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKEL--- 236
R L+ + LEA Q EE EL EQ ++ + + + EQ EL
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEE---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 237 RHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQ 296
R + + ++L + K+ L E E A +S+ L + + Q+EE+++
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEG-----AVKSKFKSTIAALEAKIAQLEEQVE 1831
Query: 297 QLLEEKLLAEKRMKENEERSRAL----EEER---EFYSSQSQALQNSLQELTAEKQQAER 349
Q EK A K +K+ +++ + + E+ER E Y Q++ +++L + ++AE
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891
Query: 350 ELKAEVKVRMDLERRLREAEGALRSLEQGLN---SKVRNKEKEE 390
E + R L+R L EA + ++ + +N SK+R +E
Sbjct: 1892 ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQE 1935
Score = 65.5 bits (158), Expect = 1e-10
Identities = 72/315 (22%), Positives = 130/315 (41%), Gaps = 23/315 (7%)
Query: 116 LAAESEFEQTQWL-----EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLD-- 168
L A+ E E+T + E L S KN E ++LE Q ++ + +E D
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555
Query: 169 ------KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELT 222
KL E L+ + +L+ ++ E +++Q + + E E E +++ L
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615
Query: 223 ARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTL-ANQSEQPPPS 281
A K +E + K+L +S + EE + +K +++ + L+ A++ E +
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 282 GGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELT 341
+ +E + QL E+ AE+ K+ + L EE S ALQ+ + L
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 342 AEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKR 401
A Q E EL+ E + R+R+A L L ++ +K E R +
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER--- 1792
Query: 402 FFEECIRNAELEAKM 416
+N EL +K+
Sbjct: 1793 ------QNKELRSKL 1801
Score = 58.2 bits (139), Expect = 2e-08
Identities = 79/347 (22%), Positives = 143/347 (41%), Gaps = 73/347 (21%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQ---LGEAMIKSLEAQGLQLAKEKQEYLDKLME 172
L + E +Q ++ ++L E ++ K A EA + E + L LA+ +E L
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----- 1496
Query: 173 ETEELCLQREQREELERLNQVLEAEKQ--------------QFEEVVQELRMEQEQIKRE 218
E +EELER N++L+AE + + E+ + L + E++K +
Sbjct: 1497 ---------EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 219 LELTARCLKGVEQEKKELRHLTESLQ-------QTLEELSIEKKKTLE-MLEENENHLQT 270
LE L+ E K L ++L+ Q +E + EK++ L+ L E E L+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 271 LANQ-----SEQPPPSGGL-------HSNLRQIEEKMQQLLEEKLLAEKR---------- 308
Q + + G L S ++ EE ++QL KL A+ +
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL--RKLQAQMKDFQRELEDAR 1665
Query: 309 ---------MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRM 359
KENE+++++LE + A + + ++ EK++ EL + + R
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725
Query: 360 DLERRLREAEGALRSLEQGLNSKVRNKE-KEERMRADVSHLKRFFEE 405
L+ R E + LE+ L + N E +R+R ++ E
Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Score = 56.2 bits (134), Expect = 7e-08
Identities = 55/230 (23%), Positives = 104/230 (45%), Gaps = 10/230 (4%)
Query: 156 GLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQ--- 212
G +L K E D L + L+ ++ +E+ L + L+ E + E VQE+R +
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 213 -EQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTL 271
E++ +LE R +++ K+ L L L L K++ ++ E +Q L
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 272 ANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQ 331
++ S G + ++ +K+ +L E + E E ++ L ++ SSQ Q
Sbjct: 1265 QSKC-----SDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 332 ALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNS 381
Q LQE T +K +L+ + R L+ +L E A ++LE+ +++
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 79.7 bits (195), Expect = 6e-15
Identities = 76/313 (24%), Positives = 143/313 (45%), Gaps = 40/313 (12%)
Query: 114 ILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEE 173
+L +AE+E E E Q++ K+ EA K LE + + L KEK + ++ E
Sbjct: 842 LLKSAETEKEMATMKEEFQKTKDELAKS----EAKRKELEEKMVTLLKEKNDLQLQVQSE 897
Query: 174 ------TEELCLQ---------------REQREELERLNQVLEAEKQQFEEVVQELRMEQ 212
EE C Q E+ EE E +N L A+K++ E+ EL+ +
Sbjct: 898 ADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDI 957
Query: 213 EQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLA 272
+ ++ L + E + K L L +T+ +LS EKK E H QTL
Sbjct: 958 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKAL------QETHQQTLD 1011
Query: 273 NQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERS-RALEEEREFYSSQSQ 331
+ + L ++E+++ LE L EK+++ + ER+ R LE + + +
Sbjct: 1012 DLQAEEDKVNILTKAKTKLEQQVDD-LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070
Query: 332 ALQNSLQELTAEKQQAERE-------LKAEVKVRMDLERRLREAEGALRSLEQGLNSKVR 384
++N Q+L + ++ E E ++ E V + L+++++E + + L + + ++
Sbjct: 1071 DMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERA 1130
Query: 385 NKEKEERMRADVS 397
++ K E+ R+D+S
Sbjct: 1131 SRAKAEKQRSDLS 1143
Score = 62.4 bits (150), Expect = 9e-10
Identities = 82/338 (24%), Positives = 147/338 (43%), Gaps = 63/338 (18%)
Query: 114 ILLAAESEFEQTQW-LEMLQESGKVT----WKNAQLGEAMIKSLEAQGLQLAKEKQEYLD 168
+L + ++E+TQ LE Q+ + +K + E + LE L +E +
Sbjct: 1455 VLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLET----LRRENKNLQQ 1510
Query: 169 KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQE--------------LRMEQEQ 214
++ + TE++ +Q ELE++ + +E EK + + ++E +++E Q
Sbjct: 1511 EISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQ 1570
Query: 215 IKRELE-LTARCLKGVEQEKKELRHLTESLQQTL--------EELSIEKKK--TLEMLEE 263
+K E++ A + ++Q K+ + E++Q TL + L ++KK L +E
Sbjct: 1571 VKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEI 1630
Query: 264 NENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEER 323
NH LA +S LR L E +L + ++ E+ L+E+
Sbjct: 1631 QLNHANRLAAES------------LRNYRNTQGILKETQLHLDDALRGQED----LKEQL 1674
Query: 324 EFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKV 383
++ LQ ++EL A +Q ER K E+ L +A ++ L S +
Sbjct: 1675 AIVERRANLLQAEIEELWATLEQTERSRKI-------AEQELLDASERVQLLHTQNTSLI 1727
Query: 384 RNKEKEERMRADVSHLKRFFEECI---RNAELEAKMPV 418
K+K E DVS L+ EE I RNAE +AK +
Sbjct: 1728 NTKKKLEN---DVSQLQSEVEEVIQESRNAEEKAKKAI 1762
Score = 60.8 bits (146), Expect = 3e-09
Identities = 64/285 (22%), Positives = 127/285 (44%), Gaps = 33/285 (11%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELE 188
E L+E + + A L +A I+ L A Q + ++ +L++ +E + L Q L
Sbjct: 1668 EDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1727
Query: 189 RLNQVLEAEKQQF----EEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQ 244
+ LE + Q EEV+QE R +E+ K+ + A + +++E+ HL
Sbjct: 1728 NTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHL----- 1782
Query: 245 QTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGG------LHSNLRQIEEKMQQL 298
++ + LE+ LQ +++EQ GG L + +R++E +++
Sbjct: 1783 ----------ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENE 1832
Query: 299 LEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTA-------EKQQAEREL 351
+ A K ++++E R + L + E LQ+ + +L A + ++AE +
Sbjct: 1833 QKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQS 1892
Query: 352 KAEVKVRMDLERRLREAEGALRSLEQGLNS-KVRNKEKEERMRAD 395
A + L+ L EAE E +N +V+++E ++ A+
Sbjct: 1893 NANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
Score = 60.5 bits (145), Expect = 4e-09
Identities = 50/243 (20%), Positives = 112/243 (46%), Gaps = 20/243 (8%)
Query: 169 KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKG 228
K E +E+ +E+ ++ + EA++++ EE + L E+ ++ +++ A L
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 229 VEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNL 288
E+ ++L L+ ++E++ + EE E + + A + + L ++
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAE------EEEEINAELTAKKRKLEDECSELKKDI 957
Query: 289 RQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAE 348
+E + ++ +EK E ++K E L+E S + +ALQ + Q+ + Q E
Sbjct: 958 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEE 1017
Query: 349 RELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIR 408
++ K + LE+++ + EG+L E+E+++R D+ KR E ++
Sbjct: 1018 DKVNILTKAKTKLEQQVDDLEGSL--------------EQEKKLRMDLERAKRKLEGDLK 1063
Query: 409 NAE 411
A+
Sbjct: 1064 LAQ 1066
Score = 52.4 bits (124), Expect = 1e-06
Identities = 84/401 (20%), Positives = 177/401 (44%), Gaps = 33/401 (8%)
Query: 113 NILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLME 172
NIL A+++ EQ ++ L+ S + K E + LE L+LA+E ++ +
Sbjct: 1021 NILTKAKTKLEQQ--VDDLEGSLEQEKKLRMDLERAKRKLEGD-LKLAQESTMDMENDKQ 1077
Query: 173 ETEELCLQREQREELERLNQVLEAEKQQFEEV-----VQELRMEQEQIKRELELTARCLK 227
+ +E + +++E E N + + E +Q E+ ++EL+ E++ E+E
Sbjct: 1078 QLDE----KLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRA 1133
Query: 228 GVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPP-PSGGLHS 286
E+++ +L E + + LEE +E+ ++ E Q L E+ + +
Sbjct: 1134 KAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVA 1193
Query: 287 NLRQIEEKMQQLLEEKLLAEKRMKENEERSRA-LEEEREFYSSQSQALQNSLQELTAEKQ 345
LR+ L E++ +R+K+ E+ ++ L+ E + SS ++A+ + L +
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCR 1253
Query: 346 QAERELKAEVKVRMDLERRLREAEGALRS-LEQGLNSKVRNKEKEERMRADVSHLKRFFE 404
E ++ +E+K + + ++RL A R+ L+ R ++++ + + +S K+
Sbjct: 1254 SLEDQV-SELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST 1312
Query: 405 ECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTS---- 460
+ I + + + KN++ H + R C R + Q ++
Sbjct: 1313 QQIEELKHQLEEETKAKNAL-AHALQSSR-HDCDLLREQYEEEQEGKAELQRALSKANSE 1370
Query: 461 --------QLDA-NNMEELKEVAKRLSRDQRFRESIYHIMA 492
+ DA EEL+E K+L+ QR +E+ H+ A
Sbjct: 1371 VAQWRTKYETDAIQRTEELEEAKKKLA--QRLQEAEEHVEA 1409
Score = 51.2 bits (121), Expect = 2e-06
Identities = 87/431 (20%), Positives = 171/431 (39%), Gaps = 69/431 (16%)
Query: 103 MKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKE 162
+K+ D N ++++ + L++ + + +I L AQ +L E
Sbjct: 1227 LKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTE 1286
Query: 163 KQEYLDKLMEETEELCLQ-----REQREELERLNQVLEAE---KQQFEEVVQELRME--- 211
EY + ++E + L Q + +++E L LE E K +Q R +
Sbjct: 1287 AGEY-SRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDL 1345
Query: 212 -QEQIKRELELTARCLKGVEQEKKEL-----RHLTESLQQTLEELSIEKKKTLEMLEENE 265
+EQ + E E A + + + E+ ++ T+++Q+T EEL KKK + L+E E
Sbjct: 1346 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQEAE 1404
Query: 266 NHL--------------QTLANQSE--------QPPPSGGLHSNLRQIEEKMQQLLE--E 301
H+ Q L N+ E L R ++ + + + E
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE 1464
Query: 302 KLLAEKRMKENEERSRALE------------EEREFYSSQSQALQNSLQELTAEKQQAER 349
+ AE + E RS + E ++ E +++ LQ + +LT + + +
Sbjct: 1465 ETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGK 1524
Query: 350 ELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRN 409
++ K++ +E+ E + AL E L + K R++ +++ +K + I
Sbjct: 1525 QIHELEKIKKQVEQEKCEIQAALEEAEASLE---HEEGKILRIQLELNQVKSEVDRKI-- 1579
Query: 410 AELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEE 469
AE + ++ + +N TR +++ + S ND + M D N ME
Sbjct: 1580 AEKDEEIDQLKRNH-------TRVVETMQSTLDAEIRSRNDALRVKKKMEG--DLNEMEI 1630
Query: 470 LKEVAKRLSRD 480
A RL+ +
Sbjct: 1631 QLNHANRLAAE 1641
Score = 48.1 bits (113), Expect = 2e-05
Identities = 84/399 (21%), Positives = 157/399 (39%), Gaps = 33/399 (8%)
Query: 37 KRPFGRPSAKWSRRFFIIKESFLLYYSESEKKSFETNKYFNIHPKGVIPLGGCLVEPK-- 94
+R F + ++W +++ + ES S E K N++ + + L E K
Sbjct: 1449 QRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNL 1508
Query: 95 --EEPSMPYAMKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSL 152
E + + + H + + E E+ + L+E+ A L K L
Sbjct: 1509 QQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEA------EASLEHEEGKIL 1562
Query: 153 EAQGLQLAKEKQEYLDKLMEETEELC-LQREQREELERLNQVLEAE----------KQQF 201
Q L+L + K E K+ E+ EE+ L+R +E + L+AE K++
Sbjct: 1563 RIQ-LELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKM 1621
Query: 202 EEVVQELRMEQEQIKRELELTARCLKGVEQEKKELR-HLTESL--QQTLEELSIEKKKTL 258
E + E+ ++ R + R + + KE + HL ++L Q+ L+E ++
Sbjct: 1622 EGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRA 1681
Query: 259 EMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRA 318
+L+ L Q+E+ L E++Q L + K+ E
Sbjct: 1682 NLLQAEIEELWATLEQTERSRKIA--EQELLDASERVQLLHTQNTSLINTKKKLENDVSQ 1739
Query: 319 LEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQG 378
L+ E E +S+ + ++ + ELK E LER + E ++ L+
Sbjct: 1740 LQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1799
Query: 379 LNSKVR-----NKEKEERMRADVSHLKRFFE-ECIRNAE 411
L+ + K++ +++ A V L+ E E RNAE
Sbjct: 1800 LDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAE 1838
Score = 43.5 bits (101), Expect = 5e-04
Identities = 38/197 (19%), Positives = 100/197 (50%), Gaps = 12/197 (6%)
Query: 124 QTQWLEMLQES--GKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQR 181
Q++ E++QES + K A AM+ A+ L+ ++ +L+++ + E+
Sbjct: 1741 QSEVEEVIQESRNAEEKAKKAITDAAMM----AEELKKEQDTSAHLERMKKNLEQTVKDL 1796
Query: 182 EQR-EELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLT 240
+ R +E E+L L+ K+Q +++ +R + +++ E + A +KG+ + ++ ++ LT
Sbjct: 1797 QHRLDEAEQL--ALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELT 1854
Query: 241 ESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLE 300
++ + + + + ++ L+ + A ++E+ S S R+++ ++++ E
Sbjct: 1855 YQTEEDRKNV-LRLQDLVDKLQAKVKSYKRQAEEAEE--QSNANLSKFRKLQHELEEAEE 1911
Query: 301 EKLLAEKRMKENEERSR 317
+AE ++ + +SR
Sbjct: 1912 RADIAESQVNKLRVKSR 1928
Score = 37.0 bits (84), Expect = 0.042
Identities = 39/164 (23%), Positives = 72/164 (43%), Gaps = 7/164 (4%)
Query: 254 KKKTLEMLEENENHLQTLANQSEQPPPS-GGLHSNLRQIEEKMQQLLEEKLLAEKRMKEN 312
K K L E E + T+ + ++ + +++EEKM LL+EK + +++
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSE 897
Query: 313 EERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGAL 372
+ EE E L+ ++E+T E+ + E E+ AE+ + +R+L + L
Sbjct: 898 ADSLADAEERCEQLIKNKIQLEAKIKEVT-ERAEEEEEINAELTAK---KRKLEDECSEL 953
Query: 373 RSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKM 416
+ L + EKE+ A + +K EE E AK+
Sbjct: 954 KKDIDDLELTLAKVEKEK--HATENKVKNLTEEMAGLDETIAKL 995
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 79.0 bits (193), Expect = 1e-14
Identities = 87/386 (22%), Positives = 171/386 (44%), Gaps = 36/386 (9%)
Query: 114 ILLAAESEFEQTQWLEMLQ----ESGKVTWKNAQLGEAMIKSL------------EAQGL 157
+L +AE+E E E Q E K K +L E M+ L EA+GL
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 158 QLAKEKQEYLDKLMEETEELCLQ-REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIK 216
A+E+ + L K + E + E+ E+ E +N L A+K++ E+ EL+ + + ++
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
L + E + K L L +T+ +L+ EKK E H QTL +
Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL------QEAHQQTLDDLQA 1018
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERS-RALEEEREFYSSQSQALQN 335
+ L ++E+++ L E L EK+++ + ER+ R LE + + ++N
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVDDL-EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 336 SLQELTAEKQQAEREL-------KAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEK 388
Q+L + ++ E E+ + E + + L+++++E + + LE+ + ++ ++ K
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137
Query: 389 EERMRADVSHLKRFFEECIRNA--ELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSST 446
E+ R+D+S E + A A++ + K K ++ H ++T
Sbjct: 1138 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1197
Query: 447 SWNDMKPSQSFMTSQLDANNMEELKE 472
S + + Q+D N++ +K+
Sbjct: 1198 LRKKHADSVAELGEQID--NLQRVKQ 1221
Score = 68.2 bits (165), Expect = 2e-11
Identities = 72/338 (21%), Positives = 150/338 (44%), Gaps = 27/338 (7%)
Query: 94 KEEPSMPYAMKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLE 153
++E + ++ + + G++ LA ES + + L E K ++ I+ +
Sbjct: 1045 EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQ 1104
Query: 154 AQGLQLAKEKQEYLDKLMEETEELCLQREQREELER----LNQVLEAEKQQFEEV----- 204
A G+QL K+ +E ++ E EE+ +R R + E+ L++ LE ++ EE
Sbjct: 1105 ALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1164
Query: 205 ------------VQELRMEQEQIKRELELTARCLKGVEQEK-KELRHLTESLQQTLEELS 251
Q++R + E+ + E TA L+ + EL ++LQ+ ++L
Sbjct: 1165 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1224
Query: 252 IEKKKTLEMLEENENHLQTLA----NQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEK 307
EK + +++ ++++T++ N + S L+ EE+ Q+L+ +
Sbjct: 1225 KEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRG 1284
Query: 308 RMK-ENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLR 366
R++ E+ E SR L+E+ S S+ Q Q++ K+Q E E+KA+ + L+
Sbjct: 1285 RLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRH 1344
Query: 367 EAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFE 404
+ + E+ SK + + +V+ + +E
Sbjct: 1345 DCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYE 1382
Score = 55.8 bits (133), Expect = 9e-08
Identities = 69/319 (21%), Positives = 137/319 (42%), Gaps = 42/319 (13%)
Query: 118 AESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEEL 177
AE E Q + + E K+ KNA E + LE L +E + ++ + TE++
Sbjct: 1471 AELEASQKEARSLGTELFKI--KNAY--EESLDQLET----LKRENKNLQQEISDLTEQI 1522
Query: 178 CLQREQREELERLNQVLEAEKQQFEEVVQE--------------LRMEQEQIKRELE-LT 222
++ ELE++ + +E EK + + ++E +++E Q+K E++
Sbjct: 1523 AEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1582
Query: 223 ARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSG 282
A + ++Q K+ + ES+Q TL+ + + + ++ E L + Q
Sbjct: 1583 AEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1642
Query: 283 GLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTA 342
LR L + ++ + ++ E+ L+E+ ++ LQ ++EL A
Sbjct: 1643 A--EALRNYRNTQGILKDTQIHLDDALRSQED----LKEQLAMVERRANLLQAEIEELRA 1696
Query: 343 EKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRF 402
+Q ER K E+ L +A ++ L S + K+K + D+S ++
Sbjct: 1697 TLEQTERSRKI-------AEQELLDASERVQLLHTQNTSLINTKKK---LETDISQMQGE 1746
Query: 403 FEECI---RNAELEAKMPV 418
E+ + RNAE +AK +
Sbjct: 1747 MEDILQEARNAEEKAKKAI 1765
Score = 48.9 bits (115), Expect = 1e-05
Identities = 75/377 (19%), Positives = 152/377 (40%), Gaps = 60/377 (15%)
Query: 103 MKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKE 162
MK+ D N+ ++++ + L++ + + +I L AQ +L E
Sbjct: 1230 MKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTE 1289
Query: 163 KQEYLDKLMEETEELCLQREQ-----REELERLNQVLEAE---KQQFEEVVQELRME--- 211
E+ + ++E E L Q + +++E L + LE E K +Q R +
Sbjct: 1290 SGEF-SRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 212 -QEQIKRELELTARCLKGVEQEKKEL-----RHLTESLQQTLEELSIEKKKTLEMLEENE 265
+EQ + E E A + + + E+ ++ T+++Q+T EEL KKK + L+ E
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQAAE 1407
Query: 266 NHL--------------QTLANQSEQ--------PPPSGGLHSNLRQIEEKMQQLLE--E 301
H+ Q L N+ E L R ++ + + + E
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCE 1467
Query: 302 KLLAEKRMKENEERSRALE------------EEREFYSSQSQALQNSLQELTAEKQQAER 349
+ AE + E RS E ++ E +++ LQ + +LT + + +
Sbjct: 1468 ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1527
Query: 350 ELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRN 409
+ K++ +E+ E + AL E L + K R++ +++ +K + I
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLE---HEEGKILRIQLELNQVKSEVDRKI-- 1582
Query: 410 AELEAKMPVIMKNSVYI 426
AE + ++ + +N + I
Sbjct: 1583 AEKDEEIDQLKRNHIRI 1599
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/265 (23%), Positives = 117/265 (44%), Gaps = 39/265 (14%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELE 188
E L+E + + A L +A I+ L A Q + ++ +L++ +E + L Q L
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730
Query: 189 RLNQVLEAEKQQF----EEVVQELR--------------MEQEQIKRELELTARCLKGVE 230
+ LE + Q E+++QE R M E++K+E + +A +E
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH----LE 1786
Query: 231 QEKKELRHLTESLQQTL---EELSIE-KKKTLEMLEENENHL--QTLANQSEQPPPSGGL 284
+ KK + + LQ L E+L+++ KK ++ LE L + + Q GL
Sbjct: 1787 RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGL 1846
Query: 285 HSNLRQIEEKMQQLLEEKL-------LAEK---RMKENEERSRALEEEREFYSSQSQALQ 334
+ R+++E Q E++ L +K ++K + ++ EE+ ++ + LQ
Sbjct: 1847 RKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ 1906
Query: 335 NSLQELTAEKQQAEREL-KAEVKVR 358
+ L+E AE ++ K VK R
Sbjct: 1907 HELEEAEERADIAESQVNKLRVKSR 1931
Score = 43.1 bits (100), Expect = 6e-04
Identities = 38/207 (18%), Positives = 104/207 (50%), Gaps = 17/207 (8%)
Query: 124 QTQWLEMLQESGKVTWKNAQ-LGEAMIKSLEAQGLQLAKEKQEYLDKLMEET-EELCLQR 181
Q + ++LQE+ K + + +A + + E + Q E + K ME+T ++L L+
Sbjct: 1744 QGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRL 1803
Query: 182 EQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTE 241
++ E+L L+ K+Q +++ +R + +++ E + A +KG+ + ++ ++ LT
Sbjct: 1804 DEAEQL-----ALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTY 1858
Query: 242 SLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLH-SNLRQIEEKMQQLLE 300
++ + + + +++++ + +++ Q+E+ + + R+++ ++++ E
Sbjct: 1859 QTEEDRKNI----LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914
Query: 301 EKLLAEK-----RMKENEERSRALEEE 322
+AE R+K E ++ + EE
Sbjct: 1915 RADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 42.7 bits (99), Expect = 8e-04
Identities = 59/275 (21%), Positives = 117/275 (42%), Gaps = 22/275 (8%)
Query: 157 LQLAKEKQEYLDKLMEETEELC-LQREQREELERLNQVLEAEKQQFEEVVQ-ELRMEQEQ 214
L+L + K E K+ E+ EE+ L+R +E + L+AE + + ++ + +ME +
Sbjct: 1569 LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL 1628
Query: 215 IKRELELT------ARCLKGVEQEKKELR----HLTESL--QQTLEELSIEKKKTLEMLE 262
+ E++L A L+ + L+ HL ++L Q+ L+E ++ +L+
Sbjct: 1629 NEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQ 1688
Query: 263 ENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEE 322
L+ Q+E+ L E++Q L + K+ E ++ E
Sbjct: 1689 AEIEELRATLEQTERSRKIA--EQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGE 1746
Query: 323 REFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSK 382
E +++ + ++ + ELK E LER + E ++ L+ L+
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806
Query: 383 VR-----NKEKEERMRADVSHLKRFFE-ECIRNAE 411
+ K++ +++ A V L+ E E RNAE
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAE 1841
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 79.0 bits (193), Expect = 1e-14
Identities = 87/386 (22%), Positives = 171/386 (44%), Gaps = 36/386 (9%)
Query: 114 ILLAAESEFEQTQWLEMLQ----ESGKVTWKNAQLGEAMIKSL------------EAQGL 157
+L +AE+E E E Q E K K +L E M+ L EA+GL
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 158 QLAKEKQEYLDKLMEETEELCLQ-REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIK 216
A+E+ + L K + E + E+ E+ E +N L A+K++ E+ EL+ + + ++
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
L + E + K L L +T+ +L+ EKK E H QTL +
Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL------QEAHQQTLDDLQA 1018
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERS-RALEEEREFYSSQSQALQN 335
+ L ++E+++ L E L EK+++ + ER+ R LE + + ++N
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVDDL-EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 336 SLQELTAEKQQAEREL-------KAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEK 388
Q+L + ++ E E+ + E + + L+++++E + + LE+ + ++ ++ K
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137
Query: 389 EERMRADVSHLKRFFEECIRNA--ELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSST 446
E+ R+D+S E + A A++ + K K ++ H ++T
Sbjct: 1138 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1197
Query: 447 SWNDMKPSQSFMTSQLDANNMEELKE 472
S + + Q+D N++ +K+
Sbjct: 1198 LRKKHADSVAELGEQID--NLQRVKQ 1221
Score = 68.2 bits (165), Expect = 2e-11
Identities = 72/338 (21%), Positives = 150/338 (44%), Gaps = 27/338 (7%)
Query: 94 KEEPSMPYAMKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLE 153
++E + ++ + + G++ LA ES + + L E K ++ I+ +
Sbjct: 1045 EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQ 1104
Query: 154 AQGLQLAKEKQEYLDKLMEETEELCLQREQREELER----LNQVLEAEKQQFEEV----- 204
A G+QL K+ +E ++ E EE+ +R R + E+ L++ LE ++ EE
Sbjct: 1105 ALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1164
Query: 205 ------------VQELRMEQEQIKRELELTARCLKGVEQEK-KELRHLTESLQQTLEELS 251
Q++R + E+ + E TA L+ + EL ++LQ+ ++L
Sbjct: 1165 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1224
Query: 252 IEKKKTLEMLEENENHLQTLA----NQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEK 307
EK + +++ ++++T++ N + S L+ EE+ Q+L+ +
Sbjct: 1225 KEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRG 1284
Query: 308 RMK-ENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLR 366
R++ E+ E SR L+E+ S S+ Q Q++ K+Q E E+KA+ + L+
Sbjct: 1285 RLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRH 1344
Query: 367 EAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFE 404
+ + E+ SK + + +V+ + +E
Sbjct: 1345 DCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYE 1382
Score = 55.8 bits (133), Expect = 9e-08
Identities = 69/319 (21%), Positives = 137/319 (42%), Gaps = 42/319 (13%)
Query: 118 AESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEEL 177
AE E Q + + E K+ KNA E + LE L +E + ++ + TE++
Sbjct: 1471 AELEASQKEARSLGTELFKI--KNAY--EESLDQLET----LKRENKNLQQEISDLTEQI 1522
Query: 178 CLQREQREELERLNQVLEAEKQQFEEVVQE--------------LRMEQEQIKRELE-LT 222
++ ELE++ + +E EK + + ++E +++E Q+K E++
Sbjct: 1523 AEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1582
Query: 223 ARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSG 282
A + ++Q K+ + ES+Q TL+ + + + ++ E L + Q
Sbjct: 1583 AEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1642
Query: 283 GLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTA 342
LR L + ++ + ++ E+ L+E+ ++ LQ ++EL A
Sbjct: 1643 A--EALRNYRNTQGILKDTQIHLDDALRSQED----LKEQLAMVERRANLLQAEIEELRA 1696
Query: 343 EKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRF 402
+Q ER K E+ L +A ++ L S + K+K + D+S ++
Sbjct: 1697 TLEQTERSRKI-------AEQELLDASERVQLLHTQNTSLINTKKK---LETDISQMQGE 1746
Query: 403 FEECI---RNAELEAKMPV 418
E+ + RNAE +AK +
Sbjct: 1747 MEDILQEARNAEEKAKKAI 1765
Score = 48.9 bits (115), Expect = 1e-05
Identities = 75/377 (19%), Positives = 152/377 (40%), Gaps = 60/377 (15%)
Query: 103 MKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKE 162
MK+ D N+ ++++ + L++ + + +I L AQ +L E
Sbjct: 1230 MKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTE 1289
Query: 163 KQEYLDKLMEETEELCLQREQ-----REELERLNQVLEAE---KQQFEEVVQELRME--- 211
E+ + ++E E L Q + +++E L + LE E K +Q R +
Sbjct: 1290 SGEF-SRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 212 -QEQIKRELELTARCLKGVEQEKKEL-----RHLTESLQQTLEELSIEKKKTLEMLEENE 265
+EQ + E E A + + + E+ ++ T+++Q+T EEL KKK + L+ E
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQAAE 1407
Query: 266 NHL--------------QTLANQSEQ--------PPPSGGLHSNLRQIEEKMQQLLE--E 301
H+ Q L N+ E L R ++ + + + E
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCE 1467
Query: 302 KLLAEKRMKENEERSRALE------------EEREFYSSQSQALQNSLQELTAEKQQAER 349
+ AE + E RS E ++ E +++ LQ + +LT + + +
Sbjct: 1468 ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1527
Query: 350 ELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRN 409
+ K++ +E+ E + AL E L + K R++ +++ +K + I
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLE---HEEGKILRIQLELNQVKSEVDRKI-- 1582
Query: 410 AELEAKMPVIMKNSVYI 426
AE + ++ + +N + I
Sbjct: 1583 AEKDEEIDQLKRNHIRI 1599
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/265 (23%), Positives = 117/265 (44%), Gaps = 39/265 (14%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELE 188
E L+E + + A L +A I+ L A Q + ++ +L++ +E + L Q L
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730
Query: 189 RLNQVLEAEKQQF----EEVVQELR--------------MEQEQIKRELELTARCLKGVE 230
+ LE + Q E+++QE R M E++K+E + +A +E
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH----LE 1786
Query: 231 QEKKELRHLTESLQQTL---EELSIE-KKKTLEMLEENENHL--QTLANQSEQPPPSGGL 284
+ KK + + LQ L E+L+++ KK ++ LE L + + Q GL
Sbjct: 1787 RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGL 1846
Query: 285 HSNLRQIEEKMQQLLEEKL-------LAEK---RMKENEERSRALEEEREFYSSQSQALQ 334
+ R+++E Q E++ L +K ++K + ++ EE+ ++ + LQ
Sbjct: 1847 RKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ 1906
Query: 335 NSLQELTAEKQQAEREL-KAEVKVR 358
+ L+E AE ++ K VK R
Sbjct: 1907 HELEEAEERADIAESQVNKLRVKSR 1931
Score = 43.1 bits (100), Expect = 6e-04
Identities = 38/207 (18%), Positives = 104/207 (50%), Gaps = 17/207 (8%)
Query: 124 QTQWLEMLQESGKVTWKNAQ-LGEAMIKSLEAQGLQLAKEKQEYLDKLMEET-EELCLQR 181
Q + ++LQE+ K + + +A + + E + Q E + K ME+T ++L L+
Sbjct: 1744 QGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRL 1803
Query: 182 EQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTE 241
++ E+L L+ K+Q +++ +R + +++ E + A +KG+ + ++ ++ LT
Sbjct: 1804 DEAEQL-----ALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTY 1858
Query: 242 SLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLH-SNLRQIEEKMQQLLE 300
++ + + + +++++ + +++ Q+E+ + + R+++ ++++ E
Sbjct: 1859 QTEEDRKNI----LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914
Query: 301 EKLLAEK-----RMKENEERSRALEEE 322
+AE R+K E ++ + EE
Sbjct: 1915 RADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 42.7 bits (99), Expect = 8e-04
Identities = 59/275 (21%), Positives = 117/275 (42%), Gaps = 22/275 (8%)
Query: 157 LQLAKEKQEYLDKLMEETEELC-LQREQREELERLNQVLEAEKQQFEEVVQ-ELRMEQEQ 214
L+L + K E K+ E+ EE+ L+R +E + L+AE + + ++ + +ME +
Sbjct: 1569 LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL 1628
Query: 215 IKRELELT------ARCLKGVEQEKKELR----HLTESL--QQTLEELSIEKKKTLEMLE 262
+ E++L A L+ + L+ HL ++L Q+ L+E ++ +L+
Sbjct: 1629 NEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQ 1688
Query: 263 ENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEE 322
L+ Q+E+ L E++Q L + K+ E ++ E
Sbjct: 1689 AEIEELRATLEQTERSRKIA--EQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGE 1746
Query: 323 REFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSK 382
E +++ + ++ + ELK E LER + E ++ L+ L+
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806
Query: 383 VR-----NKEKEERMRADVSHLKRFFE-ECIRNAE 411
+ K++ +++ A V L+ E E RNAE
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAE 1841
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 78.2 bits (191), Expect = 2e-14
Identities = 83/377 (22%), Positives = 167/377 (44%), Gaps = 37/377 (9%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSL------------EAQGLQLAKEKQEY 166
+ EFE+T+ +E K K +L E M+ + EA L A+E+ +
Sbjct: 857 KEEFEKTK-----EELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQ 911
Query: 167 LDKLMEETEELCLQ-REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARC 225
L K + E + E+ E+ E +N L A+K++ E+ EL+ + + ++ L +
Sbjct: 912 LIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 971
Query: 226 LKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLH 285
E + K L L +T+ +L+ EKK E H QTL + + L
Sbjct: 972 KHATENKVKNLTEEMAGLDETIAKLTKEKKAL------QEAHQQTLDDLQAEEDKVNTLT 1025
Query: 286 SNLRQIEEKMQQLLEEKLLAEKRMKENEERS-RALEEEREFYSSQSQALQNSLQELTAEK 344
++E+++ L E L EK+++ + ER+ R LE + + + ++N Q+L +
Sbjct: 1026 KAKIKLEQQVDDL-EGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKL 1084
Query: 345 QQAERELKA-------EVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVS 397
++ E E+ E + M L+++++E + + LE+ + ++ ++ K E+ R+D+S
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144
Query: 398 HLKRFFEECIRNA--ELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQ 455
E + A A++ + K K ++ H ++T S
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1204
Query: 456 SFMTSQLDANNMEELKE 472
+ + Q+D N++ +K+
Sbjct: 1205 AELGEQID--NLQRVKQ 1219
Score = 67.4 bits (163), Expect = 3e-11
Identities = 71/338 (21%), Positives = 151/338 (44%), Gaps = 27/338 (7%)
Query: 94 KEEPSMPYAMKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLE 153
++E + ++ + + G++ LA ES + + L E K ++ I+ +
Sbjct: 1043 EQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQ 1102
Query: 154 AQGLQLAKEKQEYLDKLMEETEELCLQREQREELER----LNQVLEAEKQQFEEV----- 204
A G+QL K+ +E ++ E EE+ +R R + E+ L++ LE ++ EE
Sbjct: 1103 ALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1162
Query: 205 ------------VQELRMEQEQIKRELELTARCLKGVEQEK-KELRHLTESLQQTLEELS 251
Q++R + E+ + E TA L+ + EL ++LQ+ ++L
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1222
Query: 252 IEKKKTLEMLEENENHLQTLAN-QSEQPPPSGGLHSNLRQI---EEKMQQLLEEKLLAEK 307
EK + +++ ++++T++ + L L +I EE+ Q+L+ +
Sbjct: 1223 KEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRA 1282
Query: 308 RMK-ENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLR 366
R++ E+ E SR L+E+ S S+ Q Q++ K+Q E E+KA+ + L+
Sbjct: 1283 RLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRH 1342
Query: 367 EAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFE 404
+ + E+ +K + + ++V+ + +E
Sbjct: 1343 DCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYE 1380
Score = 61.6 bits (148), Expect = 2e-09
Identities = 49/243 (20%), Positives = 112/243 (46%), Gaps = 20/243 (8%)
Query: 169 KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKG 228
K E +E+ +E+ E+ + EA++++ EE + L E+ ++ +++ A L
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 229 VEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNL 288
E+ +L L+ ++E++ + +E E + + A + + L ++
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAE------DEEEINAELTAKKRKLEDECSELKKDI 958
Query: 289 RQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAE 348
+E + ++ +EK E ++K E L+E + + +ALQ + Q+ + Q E
Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE 1018
Query: 349 RELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIR 408
++ K ++ LE+++ + EG+L E+E+++R D+ KR E ++
Sbjct: 1019 DKVNTLTKAKIKLEQQVDDLEGSL--------------EQEKKIRMDLERAKRKLEGDLK 1064
Query: 409 NAE 411
A+
Sbjct: 1065 LAQ 1067
Score = 60.1 bits (144), Expect = 5e-09
Identities = 71/319 (22%), Positives = 137/319 (42%), Gaps = 42/319 (13%)
Query: 118 AESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEEL 177
AE E Q + + E K+ KNA E + LE L +E + ++ + TE++
Sbjct: 1469 AELEASQKESRSLSTELFKI--KNAY--EESLDQLET----LKRENKNLQQEISDLTEQI 1520
Query: 178 CLQREQREELERLNQVLEAEKQQFEEVVQE--------------LRMEQEQIKRELE-LT 222
++ ELE++ + +E EK + + ++E +++E Q+K E++
Sbjct: 1521 AEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1580
Query: 223 ARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSG 282
A + ++Q K+ + ES+Q TL+ + + + ++ E L + Q
Sbjct: 1581 AEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1640
Query: 283 GLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTA 342
LR L + +L + ++ E+ L+E+ ++ LQ ++EL A
Sbjct: 1641 A--EALRNYRNTQAILKDTQLHLDDALRSQED----LKEQLAMVERRANLLQAEIEELRA 1694
Query: 343 EKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRF 402
+Q ER K E+ L +A ++ L S + K+K + D+S ++
Sbjct: 1695 TLEQTERSRKI-------AEQELLDASERVQLLHTQNTSLINTKKK---LETDISQIQGE 1744
Query: 403 FEECI---RNAELEAKMPV 418
E+ I RNAE +AK +
Sbjct: 1745 MEDIIQEARNAEEKAKKAI 1763
Score = 53.5 bits (127), Expect = 4e-07
Identities = 71/349 (20%), Positives = 148/349 (42%), Gaps = 56/349 (16%)
Query: 103 MKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKE 162
MK+ D N+ ++++ + L++ + + +I L AQ +L E
Sbjct: 1228 MKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTE 1287
Query: 163 KQEYLDKLMEETEELCLQREQ-----REELERLNQVLEAE---KQQFEEVVQELRME--- 211
EY + ++E + L Q + +++E L + LE E K +Q R +
Sbjct: 1288 SGEY-SRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDL 1346
Query: 212 -QEQIKRELELTARCLKGVEQEKKEL-----RHLTESLQQTLEELSIEKKKTLEMLEENE 265
+EQ + E E A + + + E+ ++ T+++Q+T EEL KKK + L++ E
Sbjct: 1347 LREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQDAE 1405
Query: 266 NHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLL-------------------EEKLLAE 306
H++ + + L ++++ +++ L+ +K+LAE
Sbjct: 1406 EHVEAVNAK------CASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAE 1459
Query: 307 KRMK--ENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERR 364
+ K E A ++E S++ ++N+ +E + + +RE K + DL +
Sbjct: 1460 WKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQ 1519
Query: 365 LREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELE 413
+ E + LE K++ + ++E+ S L+ EE + E E
Sbjct: 1520 IAEGGKRIHELE-----KIKKQVEQEK-----SELQAALEEAEASLEHE 1558
Score = 52.0 bits (123), Expect = 1e-06
Identities = 63/265 (23%), Positives = 118/265 (44%), Gaps = 39/265 (14%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELE 188
E L+E + + A L +A I+ L A Q + ++ +L++ +E + L Q L
Sbjct: 1669 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1728
Query: 189 RLNQVLEAEKQQF----EEVVQELR--------------MEQEQIKRELELTA---RCLK 227
+ LE + Q E+++QE R M E++K+E + +A R K
Sbjct: 1729 NTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Query: 228 GVEQEKKELRHLTESLQQTLEELSIE-KKKTLEMLEENENHL--QTLANQSEQPPPSGGL 284
+EQ K+L+H + E+L+++ KK ++ LE L + + Q GL
Sbjct: 1789 NLEQTVKDLQHRLDE----AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGL 1844
Query: 285 HSNLRQIEEKMQQLLEEKL-------LAEK---RMKENEERSRALEEEREFYSSQSQALQ 334
+ R+++E Q E++ L +K ++K + ++ EE+ S+ + +Q
Sbjct: 1845 RKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQ 1904
Query: 335 NSLQELTAEKQQAEREL-KAEVKVR 358
+ L+E AE ++ K VK R
Sbjct: 1905 HELEEAEERADIAESQVNKLRVKSR 1929
Score = 43.5 bits (101), Expect = 5e-04
Identities = 30/179 (16%), Positives = 93/179 (51%), Gaps = 13/179 (7%)
Query: 151 SLEAQGLQLAKEKQEYLDKLMEETEELCLQREQR-EELERLNQVLEAEKQQFEEVVQELR 209
++ A+ L+ ++ +L+++ + E+ + R +E E+L L+ K+Q +++ +R
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL--ALKGGKKQIQKLEARVR 1824
Query: 210 MEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQ 269
+ +++ E + +KG+ + +++++ LT ++ + + + +++++ + ++
Sbjct: 1825 ELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNI----LRLQDLVDKLQAKVK 1880
Query: 270 TLANQSEQPPPSGGLH-SNLRQIEEKMQQLLEEKLLAEK-----RMKENEERSRALEEE 322
+ Q+E+ ++ S R+I+ ++++ E +AE R+K E ++ + EE
Sbjct: 1881 SYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939
Score = 41.6 bits (96), Expect = 0.002
Identities = 57/275 (20%), Positives = 116/275 (42%), Gaps = 22/275 (8%)
Query: 157 LQLAKEKQEYLDKLMEETEELC-LQREQREELERLNQVLEAEKQQFEEVVQ-ELRMEQEQ 214
L+L + K E K+ E+ EE+ ++R +E + L+AE + + ++ + +ME +
Sbjct: 1567 LELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL 1626
Query: 215 IKRELELT------ARCLKGVEQEKKELR----HLTESL--QQTLEELSIEKKKTLEMLE 262
+ E++L A L+ + L+ HL ++L Q+ L+E ++ +L+
Sbjct: 1627 NEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQ 1686
Query: 263 ENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEE 322
L+ Q+E+ L E++Q L + K+ E ++ E
Sbjct: 1687 AEIEELRATLEQTERSRKIA--EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE 1744
Query: 323 REFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSK 382
E +++ + ++ + ELK E LER + E ++ L+ L+
Sbjct: 1745 MEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1804
Query: 383 VR-----NKEKEERMRADVSHLKRFFE-ECIRNAE 411
+ K++ +++ A V L+ E E RN E
Sbjct: 1805 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNVE 1839
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 77.8 bits (190), Expect = 2e-14
Identities = 84/355 (23%), Positives = 149/355 (41%), Gaps = 58/355 (16%)
Query: 114 ILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEE 173
+L +AE+E E + ++E + T + EA K LE + + L +EK + ++ E
Sbjct: 843 LLKSAEAEKE----MATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 174 TEELCLQREQREELERLNQVLEAEKQQF-EEVVQELRMEQEQIKRELELTARC------- 225
TE L E+ E L + +LEA+ ++ E + +E M E + ++ L +C
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 226 ------LKGVEQEK-------------------------KELRHLTESLQQTLEELSIEK 254
L VE+EK KE + L E+ QQTL++L +E+
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 255 KKTLEMLEEN---ENHLQTLANQSEQPP--------PSGGLHSNLRQIEEKMQQLLEEKL 303
K +++ N E L EQ L +L+ +E + L +K
Sbjct: 1019 DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078
Query: 304 LAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLER 363
E+++K+ E L+ + + S Q ++EL A ++ E E++AE +R +E+
Sbjct: 1079 QIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEK 1138
Query: 364 R----LREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEA 414
+ RE E LE+ + E ++ A+ ++R EE E A
Sbjct: 1139 QRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193
Score = 58.2 bits (139), Expect = 2e-08
Identities = 84/402 (20%), Positives = 177/402 (44%), Gaps = 29/402 (7%)
Query: 103 MKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLG----EAMIKSLEAQGLQ 158
+++ +G I + A+ E +QT LE E K + + E +K + +
Sbjct: 1014 LQVEEDKVNGLIKINAKLE-QQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 159 LAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRE 218
L +KQ+ +KL ++ EL Q + + + E+++ + QF++ ++EL+ E+++ E
Sbjct: 1073 LENDKQQIEEKLKKKEFELS-QLQAKIDDEQVHSL------QFQKKIKELQARIEELEEE 1125
Query: 219 LELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQP 278
+E +E+++ +L E + + LEE S +EM ++ E Q + E+
Sbjct: 1126 IEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEA 1185
Query: 279 P-PSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRA-LEEEREFYSSQSQALQNS 336
+ LR+ + L E++ +R+K+ E+ ++ L+ E + +S +AL S
Sbjct: 1186 TLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKS 1245
Query: 337 LQELTAEKQQAE---RELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKE------ 387
+ + E E+KA+ + + L L + L++ L+ +V KE
Sbjct: 1246 KSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQL 1305
Query: 388 --KEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSS 445
++ + + LKR EE + A ++ + + + + +R+
Sbjct: 1306 TKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRAL 1365
Query: 446 TSWNDMKPSQSFMTSQLDA-NNMEELKEVAKRLSRDQRFRES 486
+ N + +Q + DA EEL+E K+L+ QR +E+
Sbjct: 1366 SKANS-EVAQWRTKYETDAIQRTEELEEAKKKLA--QRLQEA 1404
Score = 54.7 bits (130), Expect = 2e-07
Identities = 99/447 (22%), Positives = 181/447 (40%), Gaps = 97/447 (21%)
Query: 123 EQTQWLEMLQ-ESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQR 181
+QTQ + L + ++ +N +L ++ E+ QL K KQ +L E L+R
Sbjct: 1269 QQTQLIHDLNMQKARLQTQNGELSHR-VEEKESLISQLTKSKQALTQQLEE------LKR 1321
Query: 182 EQREELERLNQVLEAEKQQFEE--VVQELRMEQEQIKRELELTARCLKGVEQEKKELR-- 237
+ EE + N + A + + +++E E+++ K EL+ R L E + R
Sbjct: 1322 QMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQ---RALSKANSEVAQWRTK 1378
Query: 238 HLTESLQQTLEELSIEKKKTLEMLEENENHLQTLAN-----QSEQPPPSGGLHSNLRQIE 292
+ T+++Q+T EEL KKK + L+E E + +T + + + G + +R +E
Sbjct: 1379 YETDAIQRT-EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437
Query: 293 EK--------MQQLLEEKLLAEKRMKENEER---------SRALEEE----REFYSS--- 328
+Q +K+LAE + K +E + SR+L E R Y
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 329 -------QSQALQNSLQELTAE-------KQQAERELKAEVKVRMDLERRLREAEGALR- 373
+++ LQ + +LT + Q+AE+ K + + DL+ L E EG+L
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 374 -------------SLEQGLNSKVRNKEK----------------------EERMRADVSH 398
++ L+ KV K++ E R R D
Sbjct: 1558 EESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALR 1617
Query: 399 LKRFFEECIRNAELEAKMPVIMKNSVYIH-KAATRRIKSCRFHRRRSSTSWNDMKPSQSF 457
LK+ E + E++ H + ++K + H + S D+K Q
Sbjct: 1618 LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLK-EQLA 1676
Query: 458 MTSQLDANNMEELKEVAKRLSRDQRFR 484
+ + + +EEL+E+ L + +R R
Sbjct: 1677 IVERRNGLLLEELEEMKVALEQTERTR 1703
Score = 52.8 bits (125), Expect = 7e-07
Identities = 66/267 (24%), Positives = 125/267 (46%), Gaps = 38/267 (14%)
Query: 157 LQLAKEKQEYLDKLMEETEEL-CLQREQREELERLNQVLEAE----------KQQFEEVV 205
L+L++ K E K++E+ EE+ L+R + E L VL+AE K++ E +
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626
Query: 206 QELRMEQEQIKRELELTARCLKGVEQEKKELR-HLTESLQQT---LEELSIEKKKTLEML 261
E+ ++ R++ T + L+ V+ + K+ + HL ++L+ E+L+I +++ +L
Sbjct: 1627 NEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLL 1686
Query: 262 EENENHLQTLANQ------SEQPPPSGG-----LHSNLRQIEEKMQQLLEEKLLAEKRMK 310
EE E L SEQ LHS + ++L + + ++
Sbjct: 1687 EELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVE 1746
Query: 311 ENEERSRALEEEREFYSSQSQALQNSL---QELTAEKQQAERELKAEVKVRMDLERRLRE 367
+ + SR EE+ + + + + L Q+ +A ++ ++ L+ VK DL+ RL E
Sbjct: 1747 NSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK---DLQHRLDE 1803
Query: 368 AE-----GALRSLEQGLNSKVRNKEKE 389
AE G + + Q L ++VR E E
Sbjct: 1804 AEQLALKGGKKQI-QKLENRVRELENE 1829
Score = 40.8 bits (94), Expect = 0.003
Identities = 27/175 (15%), Positives = 90/175 (51%), Gaps = 8/175 (4%)
Query: 151 SLEAQGLQLAKEKQEYLDKLMEETEELCLQREQR-EELERLNQVLEAEKQQFEEVVQELR 209
++ A+ L+ ++ +L+++ + E+ + R +E E+L L+ K+Q +++ +R
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL--ALKGGKKQIQKLENRVR 1824
Query: 210 MEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQ 269
+ ++ E + A LKG + +++++ +T ++ + + + +++++ + ++
Sbjct: 1825 ELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNI----LRLQDLVDKLQAKVK 1880
Query: 270 TLANQSEQPPPSGGLH-SNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEER 323
+ Q+E+ S R+++ ++++ E +AE ++ + +SR + ++
Sbjct: 1881 SYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQK 1935
Score = 39.7 bits (91), Expect = 0.007
Identities = 41/164 (25%), Positives = 68/164 (41%), Gaps = 3/164 (1%)
Query: 254 KKKTLEMLEENENHLQTLANQSEQPPPS-GGLHSNLRQIEEKMQQLLEEKLLAEKRMKEN 312
K K L E E + T+ E+ + +++EEKM LL+EK + +++
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 313 EERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAE-VKVRMDLERRLREAEGA 371
E EE E L+ ++ELT E+ + E E+ +E V + +LE + +
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELT-ERLEEEEEMNSELVAKKRNLEDKCSSLKRD 957
Query: 372 LRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAK 415
+ LE L + K E ++S EE I E K
Sbjct: 958 IDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKK 1001
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 77.0 bits (188), Expect = 4e-14
Identities = 64/237 (27%), Positives = 120/237 (50%), Gaps = 12/237 (5%)
Query: 161 KEKQEYLD-KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQEL-RMEQ--EQIK 216
KE+Q + + EE E+L Q+ + ++ RL +V +++ +V+Q R+EQ E+ K
Sbjct: 537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK 596
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
+++E + ++ KE R E ++ +E+ + EE L+ L + E
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
+ L + +E++++ E K LAE+R +E E+ R +E RE Q + Q
Sbjct: 657 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE----QERREQER 712
Query: 337 LQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMR 393
++ E+Q AE+E + E + R+ ER L+E E ALR ++ L ++ K+K+E +
Sbjct: 713 REQ---ERQLAEQERRREQE-RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 765
Score = 72.4 bits (176), Expect = 9e-13
Identities = 72/270 (26%), Positives = 131/270 (48%), Gaps = 50/270 (18%)
Query: 140 KNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQR-----EELERLNQVL 194
K Q E + + EA+ L+ K +++ +L EE+ L+RE+R + ER+ Q+
Sbjct: 537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRL----EEVKLKREERLRKVLQARERVEQMK 592
Query: 195 EAEKQQFEEVVQEL------------------------RMEQEQIKRELELTARCLKGVE 230
E +K+Q E+ ++ +ME+ + +R+ E AR L+ ++
Sbjct: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
Query: 231 QEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQ 290
QE++E RH E LQ+ EE +K E + LA Q EQ R+
Sbjct: 653 QEEEERRH-QELLQKKKEEEQERLRKAAEA--------KRLAEQREQERREQERREQERR 703
Query: 291 IEEKMQQLL--EEKLLAEKRMKENEER---SRALEEEREFYSSQSQALQNSLQELTAEKQ 345
+E+ +Q +E+ LAE+ + +ER R L+E + Q + LQ L+E +K+
Sbjct: 704 EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE---KKK 760
Query: 346 QAERELKAEVKVRMDLERRLREAEGALRSL 375
+ E++ AE +++ + E++ +EA GA ++L
Sbjct: 761 KEEQQRLAERQLQEEQEKKAKEAAGASKAL 790
Score = 60.1 bits (144), Expect = 5e-09
Identities = 57/235 (24%), Positives = 111/235 (47%), Gaps = 25/235 (10%)
Query: 182 EQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTE 241
++R+ LE L + EAE+ + ++V ++ R E++K LK E+ +K L+
Sbjct: 537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVK---------LKREERLRKVLQ---- 583
Query: 242 SLQQTLEELSIEKKKTLEMLEENENHLQTLANQ---SEQPPPSGGLHSNLRQIEEKMQQL 298
++ +E++ EKKK +E + A + +E+ + ++E + +Q
Sbjct: 584 -ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQE 642
Query: 299 LEEKLLAEKRMKENEERSRAL-----EEEREFYSSQSQALQNSLQELTAEKQQAERELKA 353
E + L + +E E R + L EEE+E ++A + + Q ++Q RE +
Sbjct: 643 EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
Query: 354 EVKVRMDLERRLRE---AEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEE 405
+ R + ERR +E AE R ++ L ++ +E+E+ +R L+R EE
Sbjct: 703 REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
Score = 47.4 bits (111), Expect = 3e-05
Identities = 52/201 (25%), Positives = 96/201 (47%), Gaps = 26/201 (12%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEEL- 177
E +F Q + ++ + A+ A K E + + +E+ L L +E EE
Sbjct: 600 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 659
Query: 178 ---CLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKK 234
LQ+++ EE ERL + EA K+ E+ QE R EQ +RE E + + E+ ++
Sbjct: 660 HQELLQKKKEEEQERLRKAAEA-KRLAEQREQERR---EQERREQERREQERREQERREQ 715
Query: 235 ELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEK 294
E + + ++ E L E++ L+E E L+ Q + R++EEK
Sbjct: 716 ERQLAEQERRREQERLQAERE-----LQEREKALRLQKEQLQ------------RELEEK 758
Query: 295 MQQLLEEKLLAEKRMKENEER 315
++ E++ LAE++++E +E+
Sbjct: 759 KKK-EEQQRLAERQLQEEQEK 778
Score = 43.9 bits (102), Expect = 3e-04
Identities = 39/145 (26%), Positives = 72/145 (49%), Gaps = 18/145 (12%)
Query: 119 ESEFEQTQWLEMLQESGK----VTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEET 174
E E + +WL+ +E + + K + E + K+ EA+ L +E QE ++ E
Sbjct: 642 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE-QERREQERREQ 700
Query: 175 EELCLQREQREELERLNQVLEAEKQQFEEVVQE----------LRMEQEQIKRELELTAR 224
E +R ++E E+ Q+ E E+++ +E +Q LR+++EQ++RELE
Sbjct: 701 ERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELE---E 757
Query: 225 CLKGVEQEKKELRHLTESLQQTLEE 249
K EQ++ R L E ++ +E
Sbjct: 758 KKKKEEQQRLAERQLQEEQEKKAKE 782
Score = 41.6 bits (96), Expect = 0.002
Identities = 66/333 (19%), Positives = 128/333 (38%), Gaps = 28/333 (8%)
Query: 158 QLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKR 217
Q A+ K+ Y + E EE Q + EEL+ + +VV+ LR ++R
Sbjct: 445 QSARRKRSYKQAVSELDEE---QHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQR 501
Query: 218 ELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQ 277
L K ++ T ++++ LE L E Q + E
Sbjct: 502 NQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVE- 560
Query: 278 PPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSL 337
E+K ++L E KL E+R+++ + +E+ +E + + ++
Sbjct: 561 --------------EDKRRRLEEVKLKREERLRKVLQARERVEQMKE---EKKKQIEQKF 603
Query: 338 QELTAEKQQAERELKAEVKVRMDLE-RRLREAEGALRSLEQGLNSKVRNKEKEERMRADV 396
++ + ++A+ E AE K + +++ E E + E+ + +E+EER ++
Sbjct: 604 AQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQEL 663
Query: 397 SHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWND----MK 452
K+ E+ EAK + + + RR + R RR +
Sbjct: 664 LQKKKEEEQERLRKAAEAKR--LAEQREQERREQERREQERREQERREQERREQERQLAE 721
Query: 453 PSQSFMTSQLDANNMEELKEVAKRLSRDQRFRE 485
+ +L A + +E A RL ++Q RE
Sbjct: 722 QERRREQERLQAERELQEREKALRLQKEQLQRE 754
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 77.0 bits (188), Expect = 4e-14
Identities = 64/237 (27%), Positives = 120/237 (50%), Gaps = 12/237 (5%)
Query: 161 KEKQEYLD-KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQEL-RMEQ--EQIK 216
KE+Q + + EE E+L Q+ + ++ RL +V +++ +V+Q R+EQ E+ K
Sbjct: 533 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK 592
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
+++E + ++ KE R E ++ +E+ + EE L+ L + E
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
+ L + +E++++ E K LAE+R +E E+ R +E RE Q + Q
Sbjct: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE----QERREQER 708
Query: 337 LQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMR 393
++ E+Q AE+E + E + R+ ER L+E E ALR ++ L ++ K+K+E +
Sbjct: 709 REQ---ERQLAEQERRREQE-RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
Score = 72.4 bits (176), Expect = 9e-13
Identities = 72/270 (26%), Positives = 131/270 (48%), Gaps = 50/270 (18%)
Query: 140 KNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQR-----EELERLNQVL 194
K Q E + + EA+ L+ K +++ +L EE+ L+RE+R + ER+ Q+
Sbjct: 533 KERQRLENLRRKEEAEQLRRQKVEEDKRRRL----EEVKLKREERLRKVLQARERVEQMK 588
Query: 195 EAEKQQFEEVVQEL------------------------RMEQEQIKRELELTARCLKGVE 230
E +K+Q E+ ++ +ME+ + +R+ E AR L+ ++
Sbjct: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
Query: 231 QEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQ 290
QE++E RH E LQ+ EE +K E + LA Q EQ R+
Sbjct: 649 QEEEERRH-QELLQKKKEEEQERLRKAAEA--------KRLAEQREQERREQERREQERR 699
Query: 291 IEEKMQQLL--EEKLLAEKRMKENEER---SRALEEEREFYSSQSQALQNSLQELTAEKQ 345
+E+ +Q +E+ LAE+ + +ER R L+E + Q + LQ L+E +K+
Sbjct: 700 EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE---KKK 756
Query: 346 QAERELKAEVKVRMDLERRLREAEGALRSL 375
+ E++ AE +++ + E++ +EA GA ++L
Sbjct: 757 KEEQQRLAERQLQEEQEKKAKEAAGASKAL 786
Score = 60.5 bits (145), Expect = 4e-09
Identities = 57/237 (24%), Positives = 112/237 (47%), Gaps = 25/237 (10%)
Query: 180 QREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHL 239
+ ++R+ LE L + EAE+ + ++V ++ R E++K LK E+ +K L+
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVK---------LKREERLRKVLQ-- 579
Query: 240 TESLQQTLEELSIEKKKTLEMLEENENHLQTLANQ---SEQPPPSGGLHSNLRQIEEKMQ 296
++ +E++ EKKK +E + A + +E+ + ++E + +
Sbjct: 580 ---ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRK 636
Query: 297 QLLEEKLLAEKRMKENEERSRAL-----EEEREFYSSQSQALQNSLQELTAEKQQAEREL 351
Q E + L + +E E R + L EEE+E ++A + + Q ++Q RE
Sbjct: 637 QEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQ 696
Query: 352 KAEVKVRMDLERRLRE---AEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEE 405
+ + R + ERR +E AE R ++ L ++ +E+E+ +R L+R EE
Sbjct: 697 ERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 753
Score = 47.4 bits (111), Expect = 3e-05
Identities = 52/201 (25%), Positives = 96/201 (47%), Gaps = 26/201 (12%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEEL- 177
E +F Q + ++ + A+ A K E + + +E+ L L +E EE
Sbjct: 596 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
Query: 178 ---CLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKK 234
LQ+++ EE ERL + EA K+ E+ QE R EQ +RE E + + E+ ++
Sbjct: 656 HQELLQKKKEEEQERLRKAAEA-KRLAEQREQERR---EQERREQERREQERREQERREQ 711
Query: 235 ELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEK 294
E + + ++ E L E++ L+E E L+ Q + R++EEK
Sbjct: 712 ERQLAEQERRREQERLQAERE-----LQEREKALRLQKEQLQ------------RELEEK 754
Query: 295 MQQLLEEKLLAEKRMKENEER 315
++ E++ LAE++++E +E+
Sbjct: 755 KKK-EEQQRLAERQLQEEQEK 774
Score = 43.9 bits (102), Expect = 3e-04
Identities = 39/145 (26%), Positives = 72/145 (49%), Gaps = 18/145 (12%)
Query: 119 ESEFEQTQWLEMLQESGK----VTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEET 174
E E + +WL+ +E + + K + E + K+ EA+ L +E QE ++ E
Sbjct: 638 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE-QERREQERREQ 696
Query: 175 EELCLQREQREELERLNQVLEAEKQQFEEVVQE----------LRMEQEQIKRELELTAR 224
E +R ++E E+ Q+ E E+++ +E +Q LR+++EQ++RELE
Sbjct: 697 ERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELE---E 753
Query: 225 CLKGVEQEKKELRHLTESLQQTLEE 249
K EQ++ R L E ++ +E
Sbjct: 754 KKKKEEQQRLAERQLQEEQEKKAKE 778
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/333 (20%), Positives = 129/333 (38%), Gaps = 32/333 (9%)
Query: 158 QLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKR 217
Q A+ K+ Y + E EE Q + EEL+ + +VV+ LR ++R
Sbjct: 445 QSARRKRSYKQAVSELDEE---QHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQR 501
Query: 218 ELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQ 277
L K ++ T E+ +++ LE L E Q + E
Sbjct: 502 NQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEK----ERQRLENLRRKEEAEQLRRQKVE- 556
Query: 278 PPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSL 337
E+K ++L E KL E+R+++ + +E+ +E + + ++
Sbjct: 557 --------------EDKRRRLEEVKLKREERLRKVLQARERVEQMKE---EKKKQIEQKF 599
Query: 338 QELTAEKQQAERELKAEVKVRMDLE-RRLREAEGALRSLEQGLNSKVRNKEKEERMRADV 396
++ + ++A+ E AE K + +++ E E + E+ + +E+EER ++
Sbjct: 600 AQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQEL 659
Query: 397 SHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWND----MK 452
K+ E+ EAK + + + RR + R RR +
Sbjct: 660 LQKKKEEEQERLRKAAEAKR--LAEQREQERREQERREQERREQERREQERREQERQLAE 717
Query: 453 PSQSFMTSQLDANNMEELKEVAKRLSRDQRFRE 485
+ +L A + +E A RL ++Q RE
Sbjct: 718 QERRREQERLQAERELQEREKALRLQKEQLQRE 750
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 76.6 bits (187), Expect = 5e-14
Identities = 79/357 (22%), Positives = 156/357 (43%), Gaps = 31/357 (8%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVV 205
E +++ + + +E+Q DK +++ EE L E + + E EK+ EE
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ-----EREKKYREE-- 993
Query: 206 QELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENE 265
+EL+ E+EQ+ RE R + Q +K+ + LQQ E+L E+++ + E
Sbjct: 994 EELQQEEEQLLREEREKRRRQEWERQYRKK-----DELQQEEEQLLREEREKRRLQERER 1048
Query: 266 NHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREF 325
+ + Q E+ G R+ E + Q EE+L E+ EE + +ERE
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Query: 326 YSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNS--KV 383
+ + LQ ++L E+++ R R +LER+ RE E + EQ L +
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRR--------RQELERQYREEEEVQQEEEQLLREEPEK 1160
Query: 384 RNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHR-- 441
R +++ ER + L++ E+ +R + + + + Y + +R K + +R
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRRQE---RERQYREEEELQRQKRKQRYRDE 1217
Query: 442 -RRSSTSWNDMKPSQSFMTSQ---LDANNMEELKEVAKRLSRDQRFRESIYHIMATQ 494
+RS W ++ + E+ +++ RD++ ++ + H++ Q
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Score = 73.6 bits (179), Expect = 4e-13
Identities = 71/261 (27%), Positives = 124/261 (47%), Gaps = 19/261 (7%)
Query: 161 KEKQEYLDKLMEETEELCLQREQ---REELERLNQVLEAEKQQFEEVVQELRMEQEQIKR 217
+ +Q+ + EE E L+REQ RE+ R Q L E+Q E Q+LR EQ Q++R
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE--QQLRREQ-QLRR 415
Query: 218 ELELTA--RCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQS 275
E +L + + E+E+ E +H E +Q L+ E++ L+ EE E H Q Q
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475
Query: 276 ---EQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQA 332
+Q L + E + QQ E+ L ++ + E+R + EEE Q
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL----QQR 531
Query: 333 LQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERM 392
L++ Q ++++ E+ LK E + R++ ERR E L+ ++ ++ +E+E R
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERR----EQRLKREQEERRDQLLKREEERRQ 587
Query: 393 RADVSHLKRFFEECIRNAELE 413
+ + E+ ++ E+E
Sbjct: 588 QRLKREQEERLEQRLKREEVE 608
Score = 73.2 bits (178), Expect = 5e-13
Identities = 78/298 (26%), Positives = 134/298 (44%), Gaps = 27/298 (9%)
Query: 118 AESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEEL 177
++ + +W L+E K A+ + QL KE+Q L EE EE
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE-------QLRKEQQ----LLQEEEEE- 912
Query: 178 CLQREQREELERLNQVLE-AEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKEL 236
LQRE+RE+ R Q + E++Q ++ ++L E+ + +R E + K + ++KE
Sbjct: 913 -LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971
Query: 237 RHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQ 296
+ L E ++ + E++K EE + + L + + R+ +E Q
Sbjct: 972 QLLGEEPEKRRRQ---EREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 297 QLLEEKLLAEKRMKEN-EERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEV 355
+ EE+LL E+R K +ER R EE E + Q L + T +Q+ ER+ + E
Sbjct: 1029 E--EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE--TRRRQELERQYRKEE 1084
Query: 356 KVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELE 413
+++ + E+ LRE R E + R +EE ++ + L R E R ELE
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQE-----RERQCREEEELQQEEEQLLREEREKRRRQELE 1137
Score = 73.2 bits (178), Expect = 5e-13
Identities = 90/356 (25%), Positives = 155/356 (43%), Gaps = 34/356 (9%)
Query: 140 KNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQ 199
K Q E + E + + + +++Y ++ + EE L RE+RE+ R E E+Q
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR----QEWERQ 1019
Query: 200 QFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTL-EELSIEKKKTL 258
++ EL+ E+EQ+ RE E R L+ E++ +E L + +Q L EE +++ L
Sbjct: 1020 YRKK--DELQQEEEQLLRE-EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 259 EMLEENENHLQTLANQ-SEQPPPSGGLHSNLRQI--EEKMQQLLEEKLLAEKRMKENEER 315
E E LQ Q + P RQ EE++QQ E+ L E+ + +E
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 316 SRALEEEREFYSSQSQALQNS-----LQELTAE-KQQAERELKAEVKVRMDLERRLREAE 369
R EE E + Q L+ QEL + +++ E + + E +R + E+R +E E
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196
Query: 370 GALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKA 429
R E+ K + + ++E R+D LK +E NA + N VY
Sbjct: 1197 RQYREEEELQRQKRKQRYRDEDQRSD---LKWQWEPEKENA--------VRDNKVYCKGR 1245
Query: 430 ATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKEVAKRLSRDQRFRE 485
+ + + R S D+ Q + Q + + +E + + RD+ F E
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDL---QHLLGEQQERDREQERR---RWQQRDRHFPE 1295
Score = 70.1 bits (170), Expect = 5e-12
Identities = 75/339 (22%), Positives = 151/339 (44%), Gaps = 26/339 (7%)
Query: 160 AKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQ-QFEEVVQELR-----MEQE 213
A+E+Q+ + + E EE +R QR E E+ Q LE E+Q Q E Q+L+ ++++
Sbjct: 800 AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 214 QIKRELELTARCLKG---VEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQT 270
Q +R + R K +E+E+K RH + E+L +K ++L+E E LQ
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL----RKEQQLLQEEEEELQR 915
Query: 271 LANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQS 330
+ + + EE++QQ E+ L E+ + +ER R ++++ +
Sbjct: 916 EEREKRRRQEQERQYRE----EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971
Query: 331 QALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNK-EKE 389
Q L ++ +Q+ E++ + E +++ + E+ LRE R E + +++ ++E
Sbjct: 972 QLLGEEPEK--RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 390 ERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWN 449
E KR +E R E ++ + + + RR + R +R+
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE 1089
Query: 450 DMK------PSQSFMTSQLDANNMEELKEVAKRLSRDQR 482
+ + + + EEL++ ++L R++R
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Score = 69.3 bits (168), Expect = 8e-12
Identities = 81/320 (25%), Positives = 140/320 (43%), Gaps = 44/320 (13%)
Query: 123 EQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQ-------LAKEKQEYLDKLMEETE 175
E+ + + L+ ++ + + E ++K E + L+ L +E++E D+L++ E
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 176 ELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKR---ELELTARCLKGVEQE 232
E QR +RE+ ERL Q L ++++ E + QE R EQ ++KR E E + LK EQE
Sbjct: 584 ERRQQRLKREQEERLEQRL--KREEVERLEQEERREQ-RLKREEPEEERRQQLLKSEEQE 640
Query: 233 KKELRHLTESLQQTLEELSIEKKKTLEMLE-------ENENHLQTLANQSEQ-------- 277
++ + L QQ E +++++ E LE E E Q LA + ++
Sbjct: 641 ERRQQQLRRE-QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 278 --PPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQN 335
P L S + K+ K ++R +E EE+ R E E ++ + Q
Sbjct: 700 RIPKWQWQLESEADARQSKVYS-RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 336 SLQE----------LTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRN 385
+E + ++ + L A +R ER+LR E R EQ +
Sbjct: 759 QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR--EQRFLPEEEE 816
Query: 386 KEKEERMRADVSHLKRFFEE 405
KE+ R R + +F EE
Sbjct: 817 KEQRRRQRREREKELQFLEE 836
Score = 67.4 bits (163), Expect = 3e-11
Identities = 77/296 (26%), Positives = 128/296 (43%), Gaps = 41/296 (13%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLM---------EETEELCL 179
E LQE + Q E ++ LE Q L+ ++++E + + +E E
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 180 QREQREELERLNQVLEAEKQQF-----EEVVQELRMEQEQIKRELELTARCLKGVEQEKK 234
Q E+RE+ ER Q E +QQ E Q+LR EQE+ +RE +L EQE++
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR------EQEEE 371
Query: 235 ELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLR--QIE 292
QQ E + +++ L ++ Q Q + LR Q E
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Query: 293 EKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELK 352
E+ +Q E++ ++ +E EER L+ E E + + + L+ E+++ ER LK
Sbjct: 432 ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR-DQEEERRERWLK 490
Query: 353 AEVKVRMDL----------------ERRLREAEGALRSLEQGLNSKVR-NKEKEER 391
E + R + E+RL+ E R L+Q L S+ + +E+EER
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEER-LQQRLRSEQQLRREQEER 545
Score = 66.6 bits (161), Expect = 5e-11
Identities = 88/378 (23%), Positives = 160/378 (42%), Gaps = 55/378 (14%)
Query: 161 KEKQEYLDKLMEETEELCLQREQ--REELE-RLNQVLEAEKQQFEEVVQE----LRMEQE 213
K +++ L++ E EE+ + EQ REE E R Q LE + ++ EE+ QE LR EQE
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQE 1189
Query: 214 QIKRELELTARCLKGVEQEKKELRHLTESLQQTLE-------ELSIEKKKTLEMLEENEN 266
+ ++E E R + ++++K++ R+ E + L+ E ++ K ENE
Sbjct: 1190 KRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQ 1249
Query: 267 HLQTLANQSEQPPPSGGLHSNL-------------------RQIEEKMQQLLEEKLLAEK 307
Q +Q L L R E+ Q EE+ A++
Sbjct: 1250 FRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKR 1309
Query: 308 RMKENEERSRALEEERE----------FYSSQSQALQNSLQELTAEKQQAERELKAEVKV 357
R ++++E + L EERE + + Q LQ +E +Q+ +R+ + E
Sbjct: 1310 RDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER-EEQPLRRQERDRKFREEELR 1368
Query: 358 RMDLERRLREAEGALRSLEQGL-----NSKVRNKEKEERMRADVSHLKRFFEECIRNAEL 412
+ R+ E E LR E+ ++R +E+E+++R D R E+ + E
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428
Query: 413 EAK-----MPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNM 467
+ K V + ++++ R + R + Q + D +
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488
Query: 468 EELKEVAKRLSRDQRFRE 485
EE +++ +R RD++FRE
Sbjct: 1489 EEEQQL-RRQERDRKFRE 1505
Score = 66.2 bits (160), Expect = 6e-11
Identities = 62/240 (25%), Positives = 116/240 (48%), Gaps = 15/240 (6%)
Query: 159 LAKEKQEYLDKLMEETEELCLQREQREELERL-NQVLEAEKQQFEEVVQELRMEQEQIKR 217
L KE+++ ++ + EL +E+ E+L +L Q L E+Q+ E+ Q LR EQ Q++R
Sbjct: 253 LRKEEEKLQEEEPQRQREL---QEEEEQLRKLERQELRRERQEEEQQQQRLRREQ-QLRR 308
Query: 218 ELELTARCLKGVEQEKKELRHLTESL--QQTLEELSIEKKKTLEMLEENENHLQTLANQS 275
+ E R + +E++E R E QQ E +++ L +E E Q L +
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368
Query: 276 EQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQN 335
E+ L +Q+ + Q E++L E++++ ++ R + RE + Q L+
Sbjct: 369 EEERREQQLRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427
Query: 336 SLQ----ELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEER 391
+ E E+++ E+ LK E + R D +R E E R ++ +++ ++EER
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE---RHEQERRKQQLKRDQEEER 484
Score = 65.9 bits (159), Expect = 8e-11
Identities = 94/422 (22%), Positives = 180/422 (42%), Gaps = 47/422 (11%)
Query: 94 KEEPSMPYAMKISHQDFHGNILLAAESEFEQTQWLEML--QESGKVTWKNAQ-LGEAMIK 150
+EEP K Q+ L E + E+ + LE Q + W+ Q E +
Sbjct: 130 EEEPGQRRRQKRQEQERE---LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER 186
Query: 151 SLEAQGLQLAK--EKQEYLDKLMEETEELC-LQREQREEL-----ERLNQVL-EAEKQQF 201
E + LQ K E +E+ D+ EL L+R+ REE ER ++V E E++++
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW 246
Query: 202 EEVVQELRMEQEQIKRELELTARCLKGVEQ-----EKKELRHLTESLQQTLEELSIEKKK 256
+ LR E+E+++ E R L+ E+ E++ELR + +Q + L E++
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 257 TLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERS 316
+ EE + Q E+ E+ ++ E++L E+ + ++
Sbjct: 307 RRKQEEERREQQEERREQQER--------------REQQEERREQQLRREQEERREQQLR 352
Query: 317 RALEEE-REFYSSQSQALQNSLQELTAEKQ-QAERELKAEVKVRMD----LERRLREAEG 370
R EEE RE + Q + Q+L E+Q + E++L+ E ++R + E++LR +
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 371 ALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAA 430
R EQ L + + + ++E R + H + E+ ++ + E + + + H+
Sbjct: 413 LRR--EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470
Query: 431 TRRIKSCRFHRRRSSTSW-----NDMKPSQSFMTSQLDANNMEELKEVAKRLSRDQRFRE 485
R+ + R W + + Q QL E ++ KR ++R ++
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530
Query: 486 SI 487
+
Sbjct: 531 RL 532
Score = 64.7 bits (156), Expect = 2e-10
Identities = 72/275 (26%), Positives = 120/275 (43%), Gaps = 39/275 (14%)
Query: 153 EAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQ 212
+ Q + A++ QE D L E+ E Q ++R++ R LE E+++ + Q
Sbjct: 839 QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ--LEEERKRRRHTLYAKPALQ 896
Query: 213 EQIKRELELTARCLKGVEQEKKELRHLTES---------LQQTLEELSIEKKKTLEMLEE 263
EQ+++E +L + +++E++E R E LQQ E+L E+++ E
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 264 NENH-----LQTLANQ--SEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKE----- 311
+ LQ Q E+P + EE+ Q EE+LL E+R K
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 312 ----------NEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAEREL---KAEVKVR 358
+E + L EERE Q + Q +E E QQ E +L + E + R
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE---ELQQEEEQLLGEERETRRR 1073
Query: 359 MDLERRLREAEGALRSLEQGLNSKVRNKEKEERMR 393
+LER+ R+ E + EQ L + + ++ER R
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Score = 62.4 bits (150), Expect = 9e-10
Identities = 70/333 (21%), Positives = 150/333 (45%), Gaps = 56/333 (16%)
Query: 163 KQEYLDKLMEETEEL-CLQREQREELERLNQVLEAEKQ-QFEEVVQELRMEQEQIKRELE 220
+QE K ++E ++L C +REQ+ +R + E E+Q +E ++ R E++Q++R+
Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ-- 1442
Query: 221 LTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPP 280
E+E+K L + L+Q E+++ L+ EE + H Q +
Sbjct: 1443 ---------ERERKFLEE-EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK------ 1486
Query: 281 SGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQEL 340
+ E+++++ ++ E+ ++ E + LEEE++ + Q Q ++
Sbjct: 1487 -------FLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ------RKF 1533
Query: 341 TAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLK 400
E+QQ R+ + + + R D +R+ RE E + E+ ++ +E++ + R +
Sbjct: 1534 LQEEQQLRRQERGQQR-RQDRDRKFREEEQLRQEREE---QQLSRQERDRKFRLE----- 1584
Query: 401 RFFEECIRNAELEAKMPVIMKNSVYIHK-AATRRIKSCRFHRRRSSTSWNDMKPSQSFMT 459
E+ +R E E K M++ + + ++++ R + R + Q
Sbjct: 1585 ---EQKVRRQEQERK---FMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638
Query: 460 SQLDANNMEELKEVAK-------RLSRDQRFRE 485
+ D +EE ++ + R RD++FRE
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671
Score = 62.0 bits (149), Expect = 1e-09
Identities = 87/396 (21%), Positives = 165/396 (41%), Gaps = 43/396 (10%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELC 178
E E +Q + E L + T + +L K E Q + ++E + +E E C
Sbjct: 1053 EEELQQEE--EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 179 LQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRH 238
+ E+ ++ E E EK++ +E+ ++ R E+E++++E E R E+ E R
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYR-EEEEVQQEEEQLLR-------EEPEKRR 1162
Query: 239 LTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQL 298
E +Q EE +++++ + EE E Q Q + R +E +
Sbjct: 1163 RQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD 1222
Query: 299 LEEKLLAEKR--MKENEE--RSRALEEEREFYSSQ--SQALQNSLQELTAEKQQAEREL- 351
L+ + EK +++N+ + R E+ R+ SQ + Q LQ L E+Q+ +RE
Sbjct: 1223 LKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE 1282
Query: 352 ---------------KAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADV 396
+ E + + + +RR R+++ + L + K R +E + + R +
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE 1342
Query: 397 SHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQS 456
L+ E+ +R E + K + H+ R+ RR +K Q
Sbjct: 1343 QLLQEREEQPLRRQERDRK----FREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 457 F----MTSQLDANNMEELKEVAKRLS---RDQRFRE 485
QL + + +E ++LS RD++FRE
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434
Score = 61.6 bits (148), Expect = 2e-09
Identities = 82/355 (23%), Positives = 154/355 (43%), Gaps = 37/355 (10%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETE 175
L E + + Q L QE + K+ Q E + + +++E ++ +E
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 176 ELCLQREQREELERLNQVLEAE--KQQFEEVVQELRMEQEQ-----IKR--ELELTARCL 226
+ L+R+Q EE LE E ++Q E Q+LR EQE+ +KR E E + L
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 227 KGVEQEKKELRHLTESLQQTLEELSIEKKKTLEML--EENENHLQTLANQSEQPPPSGGL 284
+ +Q ++E E L + EE +E+++ + L E+ E Q L + E+
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER------- 585
Query: 285 HSNLRQIEEKMQQLLEEKLLAEK--RMKENEERSRAL-----EEEREFYSSQSQALQNSL 337
++++ + ++ LE++L E+ R+++ E R + L EEER +S+ +
Sbjct: 586 --RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Query: 338 QELTAEKQQAERE--LKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRAD 395
Q+ +QQ RE LK E + +R RE E R E ++ ++ ER+++
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL---AEEEQEQARERIKSR 700
Query: 396 VSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWND 450
+ + E +E +A+ + R+ + + RR S W +
Sbjct: 701 IPKWQWQLE-----SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Score = 61.2 bits (147), Expect = 2e-09
Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 25/255 (9%)
Query: 153 EAQGLQLAKEKQEYLDKLM--EETEELCLQREQREELE--RLNQVLEAEKQQFEEVVQ-- 206
E + QL +E+QE ++ + EE EE QR +RE E R ++ E E++Q E ++
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 207 ----ELRMEQEQIKRELELTARCLKGV----EQEKKELRHLTESLQQTLEELSIEKKKTL 258
+ ++E E R+ ++ +R K QE++E R ES Q EE +++
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ- 759
Query: 259 EMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRA 318
EE + T Q+E+ G + R +++ E +L AE+R ++ E+R
Sbjct: 760 ---EEEQRRDFTWQWQAEEKSERGRQRLSARP---PLREQRERQLRAEER-QQREQRFLP 812
Query: 319 LEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQG 378
EEE+E Q + + LQ L E+Q RE +++ + E L+E + RS EQ
Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ---EEEDGLQEDQERRRSQEQR 869
Query: 379 LNSKVRNKEKEERMR 393
+ K R + +EER R
Sbjct: 870 RDQKWRWQLEEERKR 884
Score = 58.9 bits (141), Expect = 1e-08
Identities = 66/241 (27%), Positives = 120/241 (49%), Gaps = 43/241 (17%)
Query: 163 KQEYLDKLMEETEELC---LQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKREL 219
+QE K ++E ++L L+R+ REE E+L Q E E+ + +E +++ +E+EQ++ E
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREE-EQLRQETEQEQLRRQERYRKI-LEEEQLRPER 1759
Query: 220 ELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPP 279
E + L+ E+++K E L+Q EE + +++ E E Q Q +P
Sbjct: 1760 E--EQQLRRQERDRKFREE--EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815
Query: 280 PSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQE 339
G + R EE++Q LEE+ E+R+++ +R EE+ +++Q ++ + QE
Sbjct: 1816 QRDGKY---RWEEEQLQ--LEEQ---EQRLRQERDRQYRAEEQ---FATQEKSRREE-QE 1863
Query: 340 LTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHL 399
L E++Q K R + ER+LRE +R ++KEE+ V +
Sbjct: 1864 LWQEEEQ---------KRRQERERKLRE-------------EHIRRQQKEEQRHRQVGEI 1901
Query: 400 K 400
K
Sbjct: 1902 K 1902
Score = 58.2 bits (139), Expect = 2e-08
Identities = 59/259 (22%), Positives = 129/259 (49%), Gaps = 28/259 (10%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQRE--ELERLNQVLEAEKQ-QFE 202
E ++ E Q QL +E+ D+ E E+L +RE+++ ER + LE E Q + +
Sbjct: 1601 EQQLRRQEGQQ-QLRQER----DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 203 EVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLE 262
E Q+LR ++++ RE E + L+ E+++ + ++ ++L ++++ + E
Sbjct: 1656 EREQQLRHDRDRKFREEE---QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQE 1712
Query: 263 ENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEE---KLLAEKRMKENEERSRAL 319
E + Q L + + LRQ E+ Q +E K+L E++++ E +
Sbjct: 1713 EQQLRRQELERKFRE-------EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLR 1765
Query: 320 EEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLER---RLREAEGALRSLE 376
+ER+ + + L+ +E Q+++R+ + E ++R + E R ++ +G R E
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEE 1825
Query: 377 QGLNSKVRNKEKEERMRAD 395
+ +++ +E+E+R+R +
Sbjct: 1826 E----QLQLEEQEQRLRQE 1840
Score = 57.8 bits (138), Expect = 2e-08
Identities = 64/257 (24%), Positives = 114/257 (44%), Gaps = 20/257 (7%)
Query: 169 KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKG 228
+L EE + Q+ Q +E E ++EKQ+ E R ++E ++ E R +
Sbjct: 128 QLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR 187
Query: 229 VEQEK------KELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSG 282
E+E+ E + Q EL ++K E ++ Q Q E+
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR 247
Query: 283 GLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALE-----EEREFYSSQSQAL--QN 335
+ LR+ EEK+Q EE+ ++ ++E EE+ R LE ER+ Q Q L +
Sbjct: 248 KRETVLRKEEEKLQ---EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ 304
Query: 336 SLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRAD 395
L+ E+++ ++E + E + R + + RE + R E+ ++R +++EER
Sbjct: 305 QLRRKQEEERREQQEERREQQERREQQEERREQQ-LRREQEERREQQLRREQEEERRE-- 361
Query: 396 VSHLKRFFEECIRNAEL 412
L+R EE R +L
Sbjct: 362 -QQLRREQEEERREQQL 377
Score = 55.5 bits (132), Expect = 1e-07
Identities = 63/280 (22%), Positives = 133/280 (47%), Gaps = 25/280 (8%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLE-AEKQQFEEV 204
E +++ E Q L + +++L+ EE L+R++RE+ R ++ + E++Q +
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLE------EEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 205 VQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLE-----ELSIEKKKTLE 259
+E ++ +++ R+ + L+ E+E+K L+ + +Q LE E + ++ E
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 260 MLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRAL 319
L E + + L + +P LR+ +E+ ++ EE+ L ++R E++ R+
Sbjct: 1739 QLRRQERYRKILEEEQLRPERE---EQQLRR-QERDRKFREEEQLRQER---EEQQLRSQ 1791
Query: 320 EEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLR-EAEGALRSLEQ- 377
E +R+F + + Q+L +++ + + E + E+RLR E + R+ EQ
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851
Query: 378 GLNSKVRNKE----KEERMRADVSHLKRFFEECIRNAELE 413
K R +E +EE + ++ EE IR + E
Sbjct: 1852 ATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE 1891
Score = 45.1 bits (105), Expect = 2e-04
Identities = 49/201 (24%), Positives = 90/201 (44%), Gaps = 26/201 (12%)
Query: 146 EAMIKSLEAQGLQLAKEKQ---EYLDKLMEETEELCLQREQRE--ELERLNQVLEAEKQQ 200
E ++ E + L +E+Q + L++ E E+L + EQ + ER ++LE E+ +
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756
Query: 201 FEEVVQELRM--------EQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSI 252
E Q+LR E+EQ+++E E + L+ E ++K E L+Q EE +
Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQERE--EQQLRSQESDRKFREE--EQLRQEREEQQL 1812
Query: 253 EKKKT---------LEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKL 303
++ LEE E L+ ++ + R+ E+++ Q E+K
Sbjct: 1813 RPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKR 1872
Query: 304 LAEKRMKENEERSRALEEERE 324
E+ K EE R ++E +
Sbjct: 1873 RQERERKLREEHIRRQQKEEQ 1893
Score = 34.7 bits (78), Expect = 0.21
Identities = 31/115 (26%), Positives = 50/115 (43%), Gaps = 27/115 (23%)
Query: 124 QTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQ 183
+ Q L Q GK W+ QL LE Q +L +E+ D+ E+ Q +
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQL------QLEEQEQRLRQER----DRQYRAEEQFATQEKS 1857
Query: 184 REELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRH 238
R E + L Q E +++Q +E ++ +E I+R Q+K+E RH
Sbjct: 1858 RREEQELWQEEEQKRRQ----ERERKLREEHIRR-------------QQKEEQRH 1895
Score = 31.6 bits (70), Expect = 1.8
Identities = 37/194 (19%), Positives = 79/194 (40%), Gaps = 15/194 (7%)
Query: 299 LEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVR 358
L+E+ A KE+ + R EE++ + + + L+ + +K+Q + AE + +
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 359 MDLERRLREAEGALRSLE-----QGLNSKVRNKEKEERMRADVSHLKRFF--EECIRNAE 411
+ + RL + + R E Q + + +EE++++ H F EE +R E
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 412 LEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKP---SQSFMTSQLDANNME 468
L + ++ K RR + R + W + + + +
Sbjct: 215 L-----LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 469 ELKEVAKRLSRDQR 482
EL+E ++L + +R
Sbjct: 270 ELQEEEEQLRKLER 283
Score = 30.0 bits (66), Expect = 5.2
Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 8/123 (6%)
Query: 289 RQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQ----ELTAEK 344
R+ E + +QL EE ++R ++ +E+ R L E E Q + Q Q EL ++
Sbjct: 120 RRFEPRDRQLEEEP--GQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQR 177
Query: 345 Q--QAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRF 402
Q Q E +AE + + E L + ++R K +EE+ + R
Sbjct: 178 QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV 237
Query: 403 FEE 405
F+E
Sbjct: 238 FQE 240
>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
Length = 841
Score = 75.9 bits (185), Expect = 8e-14
Identities = 99/416 (23%), Positives = 180/416 (43%), Gaps = 58/416 (13%)
Query: 124 QTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYL---DKLMEETEELCLQ 180
+TQ L ML+E Q +A + L Q L + QE L +L+E+ +E+ +
Sbjct: 352 KTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQE 411
Query: 181 REQ-REELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTA----RCLKGVEQE-KK 234
+EQ +EL+ + E K +E+ E E+ Q K EL + + GV ++
Sbjct: 412 KEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYER 471
Query: 235 ELRHLTESLQQTLEELS----IEKKKT--LEMLEENENHLQTLANQSEQPPPSGGLHSNL 288
ELR L E ++ EEL EK +T LE L++ LQ + + G L
Sbjct: 472 ELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGA--KGWFERRL 529
Query: 289 RQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAE 348
++ EE +QQ + +E+ AL++ RE ++++ + + LQ++ + +QA+
Sbjct: 530 KEAEESLQQ-------------QQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQ 576
Query: 349 RE----------LKAEVKVRMDLERRL-REAEGALRSLEQGLNSKVRNKEKEERMRADV- 396
E LK EVK +D +R L ++ AL+ L++ L+ + + +K + D+
Sbjct: 577 EERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDIL 636
Query: 397 --SHLKRFFEECI---RNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDM 451
S + EE + N+ + S + ++ R +S R S+S
Sbjct: 637 TNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQ 696
Query: 452 KPSQSFMTSQLDANNMEELKEVAKRLSRDQR----FRESIYHIMATQPGAPSALSR 503
P + ++ EE+ E+ +RL+ Q+ E + H+ + L R
Sbjct: 697 PPRPAELSD-------EEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCR 745
Score = 60.1 bits (144), Expect = 5e-09
Identities = 92/408 (22%), Positives = 164/408 (40%), Gaps = 66/408 (16%)
Query: 124 QTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELC----- 178
+ +W EM +E ++ W+ Q + S +A+ +L +E + +KL ++ E C
Sbjct: 193 ELKW-EMEKEEKRLLWEQLQ---GLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 248
Query: 179 ---LQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKE 235
L + R ++E L Q EA+ + Q+L+ E E + L A + E+ E
Sbjct: 249 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSL---AELRDQRQGERLE 305
Query: 236 LRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQ------------PPPSGG 283
+LQ + S + ++ +E L N L+T EQ + G
Sbjct: 306 HAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTG 365
Query: 284 LHSNLRQIEEKMQQL----------LEEKLLAEKRM--------KENEERSRALEEEREF 325
L + L+Q + + + L L+E L A R+ +E E+ ++ L+E R+
Sbjct: 366 LAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKS 425
Query: 326 YSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRN 385
+ L E EK Q + EL A VR+ R +E G E+ L +
Sbjct: 426 AEKRKAMLDELAMETLQEKSQHKEELGA---VRL---RHEKEVLGVRARYERELRELHED 479
Query: 386 KEK-EERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKA------ATRRIKSCR 438
K++ EE +R + EE R ELE + + +H RR+K
Sbjct: 480 KKRQEEELRGQIR------EEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE 533
Query: 439 FHRRRSSTSWND-MKPSQSFMTSQLDANNMEELKEVAKRLSRDQRFRE 485
++ + +K + ++L EEL++V +L + Q R+
Sbjct: 534 ESLQQQQQEQEEALKQCREQHAAELKGKE-EELQDVRDQLEQAQEERD 580
Score = 55.8 bits (133), Expect = 9e-08
Identities = 78/401 (19%), Positives = 157/401 (39%), Gaps = 50/401 (12%)
Query: 138 TWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQ----REQREELERLNQV 193
T K Q EA +SL Q E+ E+ L +++ +Q +EQ E L N
Sbjct: 278 TQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNA 337
Query: 194 LEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIE 253
L E++ E ++ + A L+ + E ++L + L L+E
Sbjct: 338 LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 397
Query: 254 KKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEE---KLLAEKRMK 310
+ LE L+E + L + ++ R+ EK + +L+E + L EK
Sbjct: 398 NSRLLEQLQEIGQEKEQLTQELQE----------ARKSAEKRKAMLDELAMETLQEKSQH 447
Query: 311 ENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEG 370
+ E + L E+E +++ + L+EL +K++ E EL+ +++ R L +
Sbjct: 448 KEELGAVRLRHEKEVLGVRAR-YERELRELHEDKKRQEEELRGQIREEKARTRELETLQQ 506
Query: 371 ALRSLEQGLNS--------KVRNKEKEERMRADVSHLKRFFEECIRN--AELEAKMPVIM 420
+ L+ ++S + R KE EE ++ + ++C AEL+ K +
Sbjct: 507 TVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQ 566
Query: 421 KNSVYIHKAATRR-----------------IKSCRFHRRRSSTSWNDMKPSQSFMTSQLD 463
+ +A R + R ++ S + D+K L+
Sbjct: 567 DVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK-----RQLHLE 621
Query: 464 ANNMEELKEVAKRLSRDQRFRESIYHIMATQPGAPSALSRG 504
++L+E + + + + R + ++ ++ +PS G
Sbjct: 622 RKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTG 662
Score = 48.9 bits (115), Expect = 1e-05
Identities = 65/302 (21%), Positives = 135/302 (44%), Gaps = 25/302 (8%)
Query: 118 AESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLA--KEKQEYLDKLMEETE 175
+E EF++ Q ++L+ + N QL + + K+ G++L ++K YLDK + +
Sbjct: 6 SEEEFQRMQ-AQLLE----LRTNNYQLSDELRKN----GVELTSLRQKVAYLDKEFSKAQ 56
Query: 176 ELCLQREQREELERL---NQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQE 232
+ + ++ +E+E L N++L+A+ EE + R++ + E ++ +EQE
Sbjct: 57 KALSKSKKAQEVEVLLSENEMLQAKLHSQEE---DFRLQNSTLMAEFSKLCSQMEQLEQE 113
Query: 233 KKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIE 292
++L+ + + + L + EN + +A E+ G S + + +
Sbjct: 114 NQQLKEGAAG-AGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQ 172
Query: 293 EKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELK 352
+LA + E E + +EE+ Q Q L++S Q T+ Q+ +L
Sbjct: 173 GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLS 232
Query: 353 AEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAEL 412
++K + +E+ L++ ++ L + RNK +E + R + H + EL
Sbjct: 233 EKLK-------KKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQEL 285
Query: 413 EA 414
EA
Sbjct: 286 EA 287
Score = 40.4 bits (93), Expect = 0.004
Identities = 60/245 (24%), Positives = 101/245 (41%), Gaps = 38/245 (15%)
Query: 207 ELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENEN 266
E+ ++ E K E L L+G+E K+ T LQ+ L +LS + KK E +
Sbjct: 191 EVELKWEMEKEEKRLLWEQLQGLESSKQAE---TSRLQEELAKLSEKLKKKQESFCRLQT 247
Query: 267 HLQTLANQS-----EQPPPSGGLHSNLRQIEEKMQQLLE--EKLLAEKRMKENEERS--- 316
+TL N S E H +K+QQ LE + LAE R + ER
Sbjct: 248 EKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHA 307
Query: 317 ---RALEEEREFYSSQSQ-----------ALQNSLQEL----TAEKQQAERELKAEVKVR 358
RAL+++ S+ +Q AL+ SL L TA+ Q+ + +
Sbjct: 308 AALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLA 367
Query: 359 MDLERRLREAEGAL-------RSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAE 411
+L+++ E E + L++ L + R E+ + + + L + +E ++AE
Sbjct: 368 AELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAE 427
Query: 412 LEAKM 416
M
Sbjct: 428 KRKAM 432
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 74.3 bits (181), Expect = 2e-13
Identities = 57/267 (21%), Positives = 138/267 (51%), Gaps = 17/267 (6%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELE 188
++ ++ G+V + Q+ E + E +G Q+ +++ + ++ + E+ EQ E++
Sbjct: 151 QVREQEGQVREQEGQVREQEGQVREQEG-QVREQEGQVREQEGQMGEQEGQMGEQEEQMG 209
Query: 189 RLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLE 248
+ ++ +++Q E +++R ++EQ+ + E + + V+++++++R E +++ E
Sbjct: 210 EQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEE 269
Query: 249 ELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKR 308
++ ++++ L+ E+ E QT Q EQ +R+ EE+M++ E+ E++
Sbjct: 270 QMREQEEQMLKQKEQTEQEEQT-GEQEEQ----------MREQEEQMREQEEQMREQEEQ 318
Query: 309 MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERE---LKAEVKVRMDLERRL 365
M+E EE+ ++E + + + Q + Q E+Q E+E K E +VR E+
Sbjct: 319 MREQEEQMG--KQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR 376
Query: 366 REAEGALRSLEQGLNSKVRNKEKEERM 392
++ E + EQ + + E++E+M
Sbjct: 377 KQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Score = 68.6 bits (166), Expect = 1e-11
Identities = 57/266 (21%), Positives = 129/266 (48%), Gaps = 15/266 (5%)
Query: 129 EMLQESGKVTWKNAQLGE--AMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREE 186
++ ++ G+V + Q+GE + E Q + ++ Q+ +++ E+ E++ Q EQ E
Sbjct: 179 QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238
Query: 187 LERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQT 246
E Q E + Q+ EE ++R ++EQ++ + E ++ E++ + + TE +QT
Sbjct: 239 QEEQVQKQEEQVQKQEE---QMRKQEEQMREQEEQ----MREQEEQMLKQKEQTEQEEQT 291
Query: 247 LEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAE 306
E+ +++ +M E+ E + EQ G + + +E+M + E+ E
Sbjct: 292 GEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE 351
Query: 307 KRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLR 366
++M E EE+ + EE+ Q + + +++ + ++ E ++ + + + + ++R
Sbjct: 352 EQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR 411
Query: 367 EAEGALRSLEQGLNSKVRNKEKEERM 392
E E EQ K + +++EE M
Sbjct: 412 EQE------EQMGEQKEQMRKQEEHM 431
Score = 62.8 bits (151), Expect = 7e-10
Identities = 55/249 (22%), Positives = 126/249 (50%), Gaps = 16/249 (6%)
Query: 129 EMLQESGKVTWKNAQLGEA---MIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQRE 185
+M ++ G++ + Q+GE M K E G Q +E+ ++ M E EE ++Q E
Sbjct: 193 QMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQ--EEQMRKQEEQMGEQEEQV--QKQEE 248
Query: 186 ELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQ 245
++++ + + +++Q E +++R ++EQ+ ++ E T + + EQE+ ++R E +++
Sbjct: 249 QVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEE-QMREQEEQMRE 307
Query: 246 TLEELSIEKKKTLEMLEENENHLQTLANQSEQ----PPPSGGLHSNLRQIEEKMQQLLEE 301
E++ ++++ E E+ + + Q EQ + + EE+MQ+ E+
Sbjct: 308 QEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQ 367
Query: 302 KLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDL 361
E++M++ EE+ R EE+ Q + + +++ +K+Q RE + ++ + +
Sbjct: 368 VRKQEEQMRKQEEQMRKQEEQMR---KQEEQMGEQKEQMGEQKEQM-REQEEQMGEQKEQ 423
Query: 362 ERRLREAEG 370
R+ E G
Sbjct: 424 MRKQEEHMG 432
Score = 62.8 bits (151), Expect = 7e-10
Identities = 53/237 (22%), Positives = 119/237 (50%), Gaps = 19/237 (8%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQLGEA--MIKSLEAQGLQLAKEKQEYLDKLMEE 173
+ + E Q Q +M ++ ++ + Q+GE ++ E Q +Q +E+ ++ M E
Sbjct: 208 MGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQ-VQKQEEQMRKQEEQMRE 266
Query: 174 TEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEK 233
EE REQ E++ + + E E+Q E+ +E EQE+ RE E + + +++
Sbjct: 267 QEEQ--MREQEEQMLKQKEQTEQEEQTGEQ--EEQMREQEEQMREQE------EQMREQE 316
Query: 234 KELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEE 293
+++R E + + E++ +K++ E E+ + + Q EQ +R+ EE
Sbjct: 317 EQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ---EEQVRKQEE 373
Query: 294 KMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERE 350
+M++ E+ E++M++ EE+ + E++E Q + ++ +++ +K+Q ++
Sbjct: 374 QMRKQEEQMRKQEEQMRKQEEQ---MGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQ 427
Score = 57.8 bits (138), Expect = 2e-08
Identities = 52/284 (18%), Positives = 135/284 (47%), Gaps = 20/284 (7%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELE 188
++ ++ G+V + Q+ E + E +G +E Q + +E ++ ++ + E
Sbjct: 123 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 182
Query: 189 RLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLE 248
+ QV E E Q E+ Q E++ ++E ++ +++++++ E +++ E
Sbjct: 183 QEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQM--------QKQEEQMGEQEEQMRKQEE 234
Query: 249 ELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKR 308
++ ++++ + E+ + + + Q EQ +R+ EE+M++ EE++L +K
Sbjct: 235 QMGEQEEQVQKQEEQVQKQEEQMRKQEEQ----------MREQEEQMREQ-EEQMLKQKE 283
Query: 309 MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAEREL-KAEVKVRMDLERRLRE 367
E EE++ EE+ Q + + ++E + ++ E ++ K E ++ E+ +
Sbjct: 284 QTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQ 343
Query: 368 AEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAE 411
E + EQ + + +++EE++R +++ E+ + E
Sbjct: 344 KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEE 387
Score = 56.6 bits (135), Expect = 5e-08
Identities = 63/281 (22%), Positives = 124/281 (44%), Gaps = 5/281 (1%)
Query: 131 LQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERL 190
L + G+V + Q+ E + E +G +E Q + +E ++ ++ + E+
Sbjct: 48 LPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 107
Query: 191 NQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEEL 250
QV E E Q E+ Q EQE RE E R +G Q +++ + E Q E+
Sbjct: 108 GQVREQEGQVREQEGQV--REQEGQVREQEGQVREQEG--QVREQEGQVREQEGQVREQE 163
Query: 251 SIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMK 310
+++ ++ E+ + EQ G + + EE+M + E+ E++M
Sbjct: 164 GQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMG 223
Query: 311 ENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEG 370
E EE+ R EE+ Q Q + +Q+ + ++ E +++ + + + E ++ + +
Sbjct: 224 EQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKE 283
Query: 371 ALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAE 411
EQ + + +E+EE+MR + R EE +R E
Sbjct: 284 QTEQEEQTGEQEEQMREQEEQMREQEEQM-REQEEQMREQE 323
Score = 55.8 bits (133), Expect = 9e-08
Identities = 57/283 (20%), Positives = 126/283 (44%), Gaps = 4/283 (1%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELE 188
++ ++ G+V + Q+ E + E +G +E Q + +E ++ ++ + E
Sbjct: 53 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 112
Query: 189 RLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLE 248
+ QV E E Q E+ Q EQE RE E R +G Q +++ + E Q E
Sbjct: 113 QEGQVREQEGQVREQEGQV--REQEGQVREQEGQVREQEG--QVREQEGQVREQEGQVRE 168
Query: 249 ELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKR 308
+ +++ ++ E+ + EQ G + + EE+MQ+ E+ E++
Sbjct: 169 QEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQ 228
Query: 309 MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREA 368
M++ EE+ EE+ + Q Q + +++ + ++ E +++ + + + + + +
Sbjct: 229 MRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQE 288
Query: 369 EGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAE 411
E EQ + + +E+EE+MR ++ E+ + E
Sbjct: 289 EQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEE 331
Score = 53.5 bits (127), Expect = 4e-07
Identities = 59/284 (20%), Positives = 130/284 (45%), Gaps = 7/284 (2%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELE 188
++ ++ G+V + Q+ E + E +G +E Q + +E ++ ++ + E
Sbjct: 95 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 154
Query: 189 RLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKG-VEQEKKELRHLTESLQQTL 247
+ QV E E Q E+ Q EQE RE E R +G + +++ ++ E + +
Sbjct: 155 QEGQVREQEGQVREQEGQV--REQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQE 212
Query: 248 EELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEK 307
E++ ++++ E E+ + + Q EQ +++ EE+M++ E+ E+
Sbjct: 213 EQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ---EEQVQKQEEQMRKQEEQMREQEE 269
Query: 308 RMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLRE 367
+M+E EE+ +E+ E + + ++ ++Q E+ + E ++R E+ ++
Sbjct: 270 QMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQ 329
Query: 368 AEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAE 411
E EQ K + ++EE+M +++ EE +R E
Sbjct: 330 EEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQK-QEEQVRKQE 372
Score = 47.0 bits (110), Expect = 4e-05
Identities = 58/309 (18%), Positives = 125/309 (40%), Gaps = 14/309 (4%)
Query: 179 LQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRH 238
+ R EEL+ N L+ E Q E E+++ +++KR+LE L Q +++
Sbjct: 1 MPRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQ 60
Query: 239 LTESLQQTLEELSIEKKKTLEMLEEN----ENHLQTLANQSEQPPPSGGLHSNLRQIEEK 294
+ E Q E+ +++ ++ E+ E Q + + G + Q+ E+
Sbjct: 61 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 120
Query: 295 MQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAE 354
Q+ E+ E +++E E + R E + Q + + ++E + ++ E +++ +
Sbjct: 121 EGQVREQ----EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 176
Query: 355 VKVRMDLERRLREAEGALRSLEQGLNSKVRNK-EKEERMRADVSHLKRFFEECIRNAE-L 412
+ E ++RE EG + E + + E+EE+M+ + E+ + E +
Sbjct: 177 EGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQM 236
Query: 413 EAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKE 472
+ + K + K + K R + M+ + M Q + EE
Sbjct: 237 GEQEEQVQKQEEQVQKQEEQMRKQEEQMREQE----EQMREQEEQMLKQKEQTEQEEQTG 292
Query: 473 VAKRLSRDQ 481
+ R+Q
Sbjct: 293 EQEEQMREQ 301
Score = 43.1 bits (100), Expect = 6e-04
Identities = 63/282 (22%), Positives = 127/282 (45%), Gaps = 20/282 (7%)
Query: 140 KNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQ 199
KNA+L E + + +E + ++ +E KL ET+++ L +E + E+ QV E E Q
Sbjct: 12 KNAELQEEL-QLVETEKSEIQLHIKELKRKL--ETDKIPLPQEGQVR-EQEGQVREQEGQ 67
Query: 200 QFEEVVQELRMEQEQIKRELELTARCLKG-VEQEKKELRH----LTESLQQTLEELSIEK 254
E+ Q EQE RE E R +G V +++ ++R + E Q E+ +
Sbjct: 68 VREQEGQV--REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 125
Query: 255 KKTLEMLEEN----ENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMK 310
++ ++ E+ E Q + + G + Q+ E+ Q+ E+ E +++
Sbjct: 126 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ----EGQVR 181
Query: 311 ENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAEREL-KAEVKVRMDLERRLREAE 369
E E + R E + Q + + E + Q+ E ++ + E ++R E+ + E
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEE 241
Query: 370 GALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAE 411
+ EQ + + +++EE+MR ++ E+ ++ E
Sbjct: 242 QVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKE 283
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/171 (16%), Positives = 84/171 (49%), Gaps = 20/171 (11%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEA--MIKSLEAQGLQLAKEKQEYLDKLMEETEE 176
E E + + E + + + T + Q GE ++ E Q + ++ +E +++ E+ E+
Sbjct: 266 EQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQ 325
Query: 177 LCLQREQ-----------REELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARC 225
+ Q EQ +E++ + + + +++Q ++ +++R ++EQ++++ E
Sbjct: 326 MGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE----- 380
Query: 226 LKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
+ ++++++R E + + E++ +K++ E E+ + + Q E
Sbjct: 381 --QMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429
Score = 32.0 bits (71), Expect = 1.4
Identities = 25/130 (19%), Positives = 60/130 (46%), Gaps = 14/130 (10%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELC 178
E E + + E + E + W+ E M K E G E++E + K E+
Sbjct: 321 EQEEQMGKQEEQMWEQKEQMWEQK---EQMWKQEEQMG-----EQEEQMQKQEEQV---- 368
Query: 179 LQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRH 238
R+Q E++ + + + +++Q + +++ ++EQ+ + E + + ++K+++R
Sbjct: 369 --RKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRK 426
Query: 239 LTESLQQTLE 248
E + + E
Sbjct: 427 QEEHMGEQKE 436
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 73.9 bits (180), Expect = 3e-13
Identities = 70/300 (23%), Positives = 139/300 (46%), Gaps = 33/300 (11%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSL------------EAQGLQLAKEKQEY 166
+ EFE+T+ +E K K +L E M+ + EA L A+E+ +
Sbjct: 857 KEEFEKTK-----EELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQ 911
Query: 167 LDKLMEETEELCLQ-REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARC 225
L K + E + E+ E+ E +N L A+K++ E+ EL+ + + ++ L +
Sbjct: 912 LIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 971
Query: 226 LKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLH 285
E + K L L +T+ +L+ EKK E H QTL + + L
Sbjct: 972 KHATENKVKNLTEEMAGLDETIAKLTKEKKAL------QEAHQQTLDDLQMEEDKVNTLT 1025
Query: 286 SNLRQIEEKMQQLLEEKLLAEKRMKENEERS-RALEEEREFYSSQSQALQNSLQELTAEK 344
++E+++ L E L EK++ + ER+ R LE + + + +N Q+L +
Sbjct: 1026 KAKTKLEQQVDDL-EGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKL 1084
Query: 345 QQAEREL-------KAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVS 397
++ E E+ + E + + L+++++E + + LE+ + ++ ++ K E+ R+D+S
Sbjct: 1085 KKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144
Score = 61.2 bits (147), Expect = 2e-09
Identities = 77/374 (20%), Positives = 161/374 (43%), Gaps = 58/374 (15%)
Query: 121 EFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQ 180
E + Q E L+E+ K + Q E ++++ ++ L K KQ +L E E+L +
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQ----RLQNEVEDLMI- 1434
Query: 181 REQREELERLNQV---LEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELR 237
++ER N L+ +++ F++V+ E + + E+ + ELE +
Sbjct: 1435 -----DVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEAS--------------- 1474
Query: 238 HLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQ 297
Q+ LS E K EE+ +HL+TL ++ + +++++
Sbjct: 1475 ------QKESRSLSTELFKVKNAYEESLDHLETLKREN-------------KNLQQEISD 1515
Query: 298 LLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKV 357
L E+ K + E E+ + L+ E+ + + + SL+ + + + EL +V
Sbjct: 1516 LTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELN---QV 1572
Query: 358 RMDLERRLREAEGALRSLEQG----LNSKVRNKEKEERMRADVSHLKRFFEECIRNAELE 413
+ +++R++ E + L L++ + S + E R R D +K+ E + E++
Sbjct: 1573 KSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQ 1632
Query: 414 AKMPVIMKNSVYIHKAATRRI-KSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNME-ELK 471
+ T+ I K + H + +D+K + + + AN M+ E++
Sbjct: 1633 LNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERR--ANLMQAEVE 1690
Query: 472 EVAKRLSRDQRFRE 485
E+ L R +R R+
Sbjct: 1691 ELRASLERTERGRK 1704
Score = 58.9 bits (141), Expect = 1e-08
Identities = 48/243 (19%), Positives = 110/243 (45%), Gaps = 20/243 (8%)
Query: 169 KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKG 228
K E +E+ +E+ E+ + EA++++ EE + L E+ ++ +++ A L
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 229 VEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNL 288
E+ +L L+ ++E++ + +E E + + A + + L ++
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAE------DEEEINAELTAKKRKLEDECSELKKDI 958
Query: 289 RQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAE 348
+E + ++ +EK E ++K E L+E + + +ALQ + Q+ + Q E
Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEE 1018
Query: 349 RELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIR 408
++ K + LE+++ + EG+L E+E+++ D+ KR E ++
Sbjct: 1019 DKVNTLTKAKTKLEQQVDDLEGSL--------------EQEKKLCMDLERAKRKLEGDLK 1064
Query: 409 NAE 411
A+
Sbjct: 1065 LAQ 1067
Score = 52.0 bits (123), Expect = 1e-06
Identities = 56/259 (21%), Positives = 109/259 (42%), Gaps = 40/259 (15%)
Query: 141 NAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQ 200
N Q EA+ QG+ K+ Q +LD + ++L +EQ +ER +++AE
Sbjct: 1637 NRQAAEALRNLRNTQGI--LKDTQLHLDDAIRGQDDL---KEQLAMVERRANLMQAEV-- 1689
Query: 201 FEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEM 260
E+++ LE T R K EQE + + L L KKK
Sbjct: 1690 ------------EELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETD 1737
Query: 261 LEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALE 320
+ + + ++ + ++ R EEK ++ + + + + +K+ ++ S LE
Sbjct: 1738 ISQIQGEMEDIVQEA-------------RNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
Query: 321 EEREFYSSQSQALQNSLQELTAEKQQAER-ELKAEVKVRMDLERRLREAEGALRSLEQGL 379
+ ++ ++++L +AE+ LK K LE R+RE E + S ++
Sbjct: 1785 R-------MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHN 1837
Query: 380 NSKVRNKEKEERMRADVSH 398
V+ K ER ++++
Sbjct: 1838 VEAVKGLRKHERRVKELTY 1856
Score = 51.6 bits (122), Expect = 2e-06
Identities = 64/372 (17%), Positives = 149/372 (40%), Gaps = 46/372 (12%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELC-LQREQREELERLNQVLEAEKQQFEEV 204
E +K + + +KQ+ +KL ++ E+ LQ + +E +A Q ++
Sbjct: 1060 EGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDE--------QALAIQLQKK 1111
Query: 205 VQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEEN 264
++EL+ E+++ E+E E+++ +L E + + LEE +EM ++
Sbjct: 1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1171
Query: 265 ENHLQTLANQSEQ----------------PPPSGGLHSNLRQIEEKMQQLLEEKLLAEKR 308
E Q + E+ L + ++ Q+L +EK +
Sbjct: 1172 EAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKME 1231
Query: 309 MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAER---ELKAEVKVRMDLE--- 362
+ + + + + + + L++ L E+ ++++ +R EL A+ K R+ E
Sbjct: 1232 INDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQ-KARLHTESGE 1290
Query: 363 --RRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIM 420
R+L E + + L +G + + E+ +R + + K +++A + ++
Sbjct: 1291 FSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCD---LL 1347
Query: 421 KNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKEVAKRLSRD 480
+ + A ++ W + + + EEL+E K+L+
Sbjct: 1348 REQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRT-------EELEEAKKKLA-- 1398
Query: 481 QRFRESIYHIMA 492
QR +++ H+ A
Sbjct: 1399 QRLQDAEEHVEA 1410
Score = 48.9 bits (115), Expect = 1e-05
Identities = 66/294 (22%), Positives = 133/294 (45%), Gaps = 46/294 (15%)
Query: 125 TQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQ- 183
T+ + LQE+ + T + Q+ E + +L +L ++ + L+ +E+ ++LC+ E+
Sbjct: 997 TKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDD-LEGSLEQEKKLCMDLERA 1055
Query: 184 REELE---RLNQV----LEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKEL 236
+ +LE +L Q E +KQQ E +++ E ++ ++E ++++ KEL
Sbjct: 1056 KRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKEL 1115
Query: 237 RHLTESLQQTLE--------------ELSIEKKKTLEMLEENENHLQTLANQSEQPPPSG 282
+ E L++ +E +LS E ++ E LEE +++
Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK----- 1170
Query: 283 GLHSNLRQIE-EKMQQLLEEKLLAEKRMKENEERSRALEEER----EFYSSQSQALQNSL 337
R+ E +KM++ LEE L ++E + AL ++ Q +LQ
Sbjct: 1171 ------REAEFQKMRRDLEESTL------QHEATAAALRKKHADSVAELGEQIDSLQRVK 1218
Query: 338 QELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEER 391
Q+L EK + + E+ + + E R+LE L S+++ KE+E++
Sbjct: 1219 QKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQL-SEIKTKEEEQQ 1271
Score = 45.8 bits (107), Expect = 9e-05
Identities = 78/363 (21%), Positives = 146/363 (40%), Gaps = 49/363 (13%)
Query: 142 AQLGEAMIKSLEAQGLQLAKEKQEY-------------LDKLMEETEELCLQREQR---- 184
A+LGE I SL+ +L KEK E + K E++C E +
Sbjct: 1205 AELGE-QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEI 1263
Query: 185 ----EELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLT 240
EE +RL L A+K + L E + R+L+ + + + K+
Sbjct: 1264 KTKEEEQQRLINELSAQKAR-------LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQI 1316
Query: 241 ESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLE 300
E L++ LEE + K L+ + L Q E+ + +++ M +
Sbjct: 1317 EELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA------ELQRGMSKANS 1370
Query: 301 EKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMD 360
E +A+ R K + + EE E +Q LQ++ + + A + K + +++ +
Sbjct: 1371 E--VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNE 1428
Query: 361 LERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIM 420
+E + + E + + L+ K RN +K ++ K+ +EE AELEA
Sbjct: 1429 VEDLMIDVERS-NAACIALDKKQRNFDKV------LAEWKQKYEE--TQAELEASQKESR 1479
Query: 421 KNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQL--DANNMEELKEVAKRLS 478
S + K +S H +++ S +T Q+ ++ EL++V K+L
Sbjct: 1480 SLSTELFKVKNAYEESLD-HLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLD 1538
Query: 479 RDQ 481
++
Sbjct: 1539 HEK 1541
Score = 42.4 bits (98), Expect = 0.001
Identities = 36/207 (17%), Positives = 103/207 (49%), Gaps = 17/207 (8%)
Query: 124 QTQWLEMLQESGKVTWKNAQ-LGEAMIKSLEAQGLQLAKEKQEYLDKLMEET-EELCLQR 181
Q + +++QE+ K + + +A + + E + Q E + K ME+T ++L L+
Sbjct: 1742 QGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRL 1801
Query: 182 EQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTE 241
++ E+L L+ K+Q +++ +R + +++ E + +KG+ + ++ ++ LT
Sbjct: 1802 DEAEQL-----ALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTY 1856
Query: 242 SLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLH-SNLRQIEEKMQQLLE 300
++ + + + +++++ + ++ Q+E+ ++ + R+++ ++++ E
Sbjct: 1857 QTEEDRKNI----LRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKE 1912
Query: 301 EKLLAEK-----RMKENEERSRALEEE 322
+AE R+K E ++ + EE
Sbjct: 1913 RADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 36.6 bits (83), Expect = 0.055
Identities = 77/396 (19%), Positives = 161/396 (40%), Gaps = 65/396 (16%)
Query: 101 YAMKISHQDFHGNILLAAESEFEQTQWLEMLQES----GKVTWKNAQLGEAMIKSLEAQG 156
+ +I + DF + S + Q+++ + S G + + Q K G
Sbjct: 713 FPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIEIDHTQYKFGHTKVFFKAG 772
Query: 157 L--QLAKEKQEYLDKLMEETEELC----LQREQREELERLNQV--LEAEKQQFEEVVQEL 208
L L + + E L +L+ T+ +C ++ E R+ +ER + ++ + F V
Sbjct: 773 LLGTLEEMRDEKLAQLITRTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAFMNVKHWP 832
Query: 209 RMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHL 268
M+ + L LK E EK E+ ++ E ++T EEL+ + K
Sbjct: 833 WMKLYFKIKPL------LKSAETEK-EMANMKEEFEKTKEELAKTEAKR----------- 874
Query: 269 QTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSS 328
+++EEKM L++EK + +++ + EE +
Sbjct: 875 --------------------KELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIK 914
Query: 329 QSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEK 388
L+ ++E+T E+ + E E+ AE+ + +R+L + L+ L + EK
Sbjct: 915 TKIQLEAKIKEVT-ERAEDEEEINAELTAK---KRKLEDECSELKKDIDDLELTLAKVEK 970
Query: 389 EERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSW 448
E+ A + +K EE A L+ + + K + +A + + + + +T
Sbjct: 971 EK--HATENKVKNLTEEM---AGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNT-- 1023
Query: 449 NDMKPSQSFMTSQLD--ANNMEELKEVAKRLSRDQR 482
+ +++ + Q+D ++E+ K++ L R +R
Sbjct: 1024 --LTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKR 1057
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 73.6 bits (179), Expect = 4e-13
Identities = 71/311 (22%), Positives = 140/311 (45%), Gaps = 40/311 (12%)
Query: 114 ILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEE 173
+L +AE+E E E Q++ K+ EA K LE + + L +EK + ++ E
Sbjct: 840 LLKSAETEKEMATMKEEFQKTKDELAKS----EAKRKELEEKLVTLVQEKNDLQLQVQAE 895
Query: 174 TEEL------CLQ---------------REQREELERLNQVLEAEKQQFEEVVQELRMEQ 212
+E L C Q E+ E+ E +N L A+K++ E+ EL+ +
Sbjct: 896 SENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955
Query: 213 EQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLA 272
+ ++ L + E + K L L +T+ +L+ EKK E H Q L
Sbjct: 956 DDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL------QEAHQQALD 1009
Query: 273 NQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERS-RALEEEREFYSSQSQ 331
+ + L+ ++E++++ L E L EK+++ + ER+ R LE + +
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDL-ESSLEQEKKLRVDLERNKRKLEGDLKLAQESIL 1068
Query: 332 ALQNSLQELTA-------EKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVR 384
L+N Q+L E Q + +++ E + + +++++E + + LE+ + ++
Sbjct: 1069 DLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA 1128
Query: 385 NKEKEERMRAD 395
+ K E+ R+D
Sbjct: 1129 TRAKTEKQRSD 1139
Score = 73.2 bits (178), Expect = 5e-13
Identities = 80/310 (25%), Positives = 135/310 (43%), Gaps = 68/310 (21%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQR------- 181
E L+E+G VT +L K EA+ L+L ++ +E L E L++
Sbjct: 1149 ERLEEAGGVTSTQIELN----KKREAEFLKLRRDLEEAT--LQHEAMVAALRKKHADSVA 1202
Query: 182 ---EQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRH 238
EQ + L+R+ Q LE EK +F+ + +L E + + + + +E + E R
Sbjct: 1203 ELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARG 1262
Query: 239 LTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQL 298
E +Q++L EL+ +K + LQT A + RQ+EEK +
Sbjct: 1263 KNEEIQRSLSELTTQKSR-----------LQTEAGELS------------RQLEEKESIV 1299
Query: 299 LEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQ--ELTAEKQQAERELKAEV- 355
+ + ++ EE R LEEE + ++ + ALQ+S +L E+ + E+E KAE+
Sbjct: 1300 SQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1359
Query: 356 ---------------KVRMDLERRLREAEGALRSLEQGL----------NSKVRNKEK-E 389
K D +R E E A + L Q L N+K + EK +
Sbjct: 1360 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTK 1419
Query: 390 ERMRADVSHL 399
+R++ +V L
Sbjct: 1420 QRLQGEVEDL 1429
Score = 61.2 bits (147), Expect = 2e-09
Identities = 81/398 (20%), Positives = 166/398 (41%), Gaps = 62/398 (15%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELC 178
ES EQ + L + E +N + E +K + L L +KQ+ ++L ++ E C
Sbjct: 1036 ESSLEQEKKLRVDLE------RNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYC 1089
Query: 179 LQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEK----K 234
+ + E+ + L QF++ ++EL+ E+++ E+E E+++ +
Sbjct: 1090 QLQSKVEDEQTLG-------LQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYAR 1142
Query: 235 ELRHLTESLQQ----TLEELSIEKKKTLEML-------EENENHLQTLA----NQSEQPP 279
EL L+E L++ T ++ + KK+ E L E H +A ++
Sbjct: 1143 ELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVA 1202
Query: 280 PSGGLHSNLRQIEEKMQQL----------LEEKLLAEKRMKENEER-SRALEEEREFYSS 328
G NL+++++K+++ L + + + K N E+ R LE++
Sbjct: 1203 ELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARG 1262
Query: 329 QSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEK 388
+++ +Q SL ELT +K + + E +L R+L E E + L + + + E+
Sbjct: 1263 KNEEIQRSLSELTTQKSRLQTEAG-------ELSRQLEEKESIVSQLSRSKQAFTQQTEE 1315
Query: 389 EERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSW 448
+R + + K ++++ + + KA +R S W
Sbjct: 1316 LKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS---KANSEVAQW 1372
Query: 449 NDMKPSQSFMTSQLDANNMEELKEVAKRLSRDQRFRES 486
+ + + EEL+E K+L+ QR ++S
Sbjct: 1373 RTKYETDAIQRT-------EELEEAKKKLA--QRLQDS 1401
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/267 (20%), Positives = 122/267 (45%), Gaps = 34/267 (12%)
Query: 169 KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKG 228
K E +E+ +E+ ++ + EA++++ EE + L E+ ++ +++ + L
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 229 VEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNL 288
E+ +L L+ ++E++ + +E E + + A + + L ++
Sbjct: 902 AEERCDQLIKAKFQLEAKIKEVTERAE------DEEEINAELTAKKRKLEDECSELKKDI 955
Query: 289 RQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQ----NSLQELTAEK 344
+E + ++ +EK E ++K E L+E + + +ALQ +L +L AE+
Sbjct: 956 DDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Query: 345 -----------------QQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKE 387
+ E L+ E K+R+DLER R+ EG L+ ++ + +K+
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 1075
Query: 388 K-EERMRADVSHLKRFFEECIRNAELE 413
+ +ER++ K+ FE C +++E
Sbjct: 1076 QLDERLK------KKDFEYCQLQSKVE 1096
Score = 57.4 bits (137), Expect = 3e-08
Identities = 70/305 (22%), Positives = 136/305 (44%), Gaps = 34/305 (11%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEY---LDKLME 172
L ++ E EQT L+ ++ ++ + +L E I++ A + K++ +Y L++L E
Sbjct: 1091 LQSKVEDEQTLGLQFQKKIKELQARIEELEEE-IEAERATRAKTEKQRSDYARELEELSE 1149
Query: 173 ETEE--------LCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQE----QIKRELE 220
EE + L +++ E +L + LE Q E +V LR + ++ +++
Sbjct: 1150 RLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQID 1209
Query: 221 LTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPP 280
R + +E+EK E + + L ++E +S + K LE + +TL +Q
Sbjct: 1210 NLQRVKQKLEKEKSEFKLEIDDLSSSMESVS-KSKANLEKI------CRTLEDQL----- 1257
Query: 281 SGGLHSNLRQIEEKMQQLLEEKLLAEKRMK-ENEERSRALEEEREFYSSQSQALQNSLQE 339
S R E++Q+ L E + R++ E E SR LEE+ S S++ Q Q+
Sbjct: 1258 -----SEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQ 1312
Query: 340 LTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHL 399
K+Q E E KA+ + L+ + + E+ K + + ++V+
Sbjct: 1313 TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1372
Query: 400 KRFFE 404
+ +E
Sbjct: 1373 RTKYE 1377
Score = 51.6 bits (122), Expect = 2e-06
Identities = 67/258 (25%), Positives = 107/258 (41%), Gaps = 38/258 (14%)
Query: 141 NAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQ 200
N Q E + QG QL K+ Q +LD + E+L +EQ +ER +L+AE
Sbjct: 1634 NRQAAETLKHLRSVQG-QL-KDTQLHLDDALRGQEDL---KEQLAIVERRANLLQAE--- 1685
Query: 201 FEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEM 260
V+ELR EQ T R K EQE + + L L KKK
Sbjct: 1686 ----VEELRATLEQ-------TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKK---- 1730
Query: 261 LEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALE 320
LE + LQ+ + + + R EEK ++ + + + + +K+ ++ S LE
Sbjct: 1731 LETDLMQLQSEVEDASR---------DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1781
Query: 321 EEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLN 380
++ + LQ+ L E + LK K LE R+RE E L ++
Sbjct: 1782 RMKKNLEQTVKDLQHRLDE------AEQLALKGGKKQIQKLETRIRELEFELEGEQKKNT 1835
Query: 381 SKVRNKEKEERMRADVSH 398
V+ K ER ++++
Sbjct: 1836 ESVKGLRKYERRVKELTY 1853
Score = 46.6 bits (109), Expect = 5e-05
Identities = 70/344 (20%), Positives = 142/344 (41%), Gaps = 70/344 (20%)
Query: 121 EFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQ 180
E + Q E L+E+ K + Q E ++++ A+ L K KQ +L E E+L +
Sbjct: 1377 ETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQ----RLQGEVEDLMVD 1432
Query: 181 REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELT---ARCL----------- 226
E+ L L+ +++ F++V+ E + + E+ + ELE + +R L
Sbjct: 1433 VERANSLAA---ALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAY 1489
Query: 227 --------------KGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLA 272
K +EQE +L +T+ EL +K+ + +E + +Q
Sbjct: 1490 EEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL----EKSRKQIELEKADIQLAL 1545
Query: 273 NQSE-----QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERS-----RALEEE 322
++E + + L Q++ ++ + + EK +++K N +R+ AL+ E
Sbjct: 1546 EEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE 1605
Query: 323 ---REFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGL 379
R + ++ L E+ + A R+ +K LR +G L+ + L
Sbjct: 1606 VRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLK-------HLRSVQGQLKDTQLHL 1658
Query: 380 NSKVRNKE-----------KEERMRADVSHLKRFFEECIRNAEL 412
+ +R +E + ++A+V L+ E+ R +L
Sbjct: 1659 DDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKL 1702
Score = 37.4 bits (85), Expect = 0.032
Identities = 64/326 (19%), Positives = 132/326 (40%), Gaps = 47/326 (14%)
Query: 159 LAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRE 218
L + + + L KL+ T+ +C R E +++ Q E+ + + ++ +
Sbjct: 774 LEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKL 833
Query: 219 LELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQP 278
LK E EK E+ + E Q+T +EL+ + K
Sbjct: 834 FFKIKPLLKSAETEK-EMATMKEEFQKTKDELAKSEAKR--------------------- 871
Query: 279 PPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQ 338
+++EEK+ L++EK + +++ E EE + L+ ++
Sbjct: 872 ----------KELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIK 921
Query: 339 ELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSH 398
E+T E+ + E E+ AE+ + +R+L + L+ L + EKE+ A +
Sbjct: 922 EVT-ERAEDEEEINAELTAK---KRKLEDECSELKKDIDDLELTLAKVEKEK--HATENK 975
Query: 399 LKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFM 458
+K EE E AK+ K H+ A +++ N + ++S +
Sbjct: 976 VKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQA-------EEDKVNSLNKTKSKL 1028
Query: 459 TSQLD--ANNMEELKEVAKRLSRDQR 482
Q++ +++E+ K++ L R++R
Sbjct: 1029 EQQVEDLESSLEQEKKLRVDLERNKR 1054
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 73.6 bits (179), Expect = 4e-13
Identities = 87/372 (23%), Positives = 172/372 (46%), Gaps = 39/372 (10%)
Query: 142 AQLGEAMIKS------LEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLE 195
AQL +A+ KS L+A+ + L +EK + + +L E E L EQ E L + LE
Sbjct: 869 AQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLE 928
Query: 196 AEKQQFEEVVQE------------LRMEQE--QIKRELELTARCLKGVEQEKKELRHLTE 241
A ++ E V+E ++E E ++K+E++ L E+EK+ H +
Sbjct: 929 ARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVK 988
Query: 242 SLQQTLEELSIEKKKTLEMLE-ENENHLQTLAN-QSEQPPPSGGLHSNLR------QIEE 293
+L + +E L+ + K + E H QTL + E+ S +NL+ ++E
Sbjct: 989 NLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEG 1048
Query: 294 KMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKA 353
++Q + ++ E+ + + E + E E S + L L++ E Q +++
Sbjct: 1049 ALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVEN 1108
Query: 354 EVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSH----LKRFFEECIRN 409
E + L++ ++E + ++ L++ L ++ + K ER RAD++ L EE +
Sbjct: 1109 EKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEE-VGG 1167
Query: 410 AELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEE 469
+ L A++ + K K R ++ H +S S +K + ++L+ +E
Sbjct: 1168 SSL-AQLEITKKQETKFQK-LHRDMEEATLHFETTSAS---LKKRHADSLAELE-GQVEN 1221
Query: 470 LKEVAKRLSRDQ 481
L++V ++L +D+
Sbjct: 1222 LQQVKQKLEKDK 1233
Score = 63.2 bits (152), Expect = 6e-10
Identities = 79/402 (19%), Positives = 174/402 (43%), Gaps = 30/402 (7%)
Query: 92 EPKEEPSMPYAMKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKS 151
E K + ++ +A++ + +D LL + E EQ E+ + KV + Q +
Sbjct: 1334 ETKSQSALAHALQKAQRDCD---LLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENN 1390
Query: 152 LEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRME 211
+ + L K+E +L E E + + + LER L+ E + ++R
Sbjct: 1391 VIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSA 1450
Query: 212 QEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTL 271
++ ++ + + L +Q+ +E + L ++ Q+ ++ LS E K EE+ +TL
Sbjct: 1451 AARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETL 1510
Query: 272 ANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQ 331
++ + ++E++ L + K + E E+ + +EEE+ +
Sbjct: 1511 RREN-------------KNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLE 1557
Query: 332 ALQNSLQELTAEKQQAERE-LKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEE 390
+ +L+ ++ + E L+A+ ++ L + E E R + ++S + + E
Sbjct: 1558 ETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEA 1617
Query: 391 RMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATR---RIKSCRFHRRRSSTS 447
+ R +V+ LK+ EE + E+E ++ + K+ + +IK + S+
Sbjct: 1618 KSRIEVTRLKKKMEEDLN--EMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQL 1675
Query: 448 WNDMKPS-------QSFMTSQL-DANNMEELKEVAKRLSRDQ 481
+D+K S + S+L D +++E E +RLS ++
Sbjct: 1676 NSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEE 1717
Score = 54.7 bits (130), Expect = 2e-07
Identities = 57/236 (24%), Positives = 101/236 (42%), Gaps = 19/236 (8%)
Query: 157 LQLAKEKQEYLDKLMEE-TEELCLQREQREELERLNQVLEAEK---QQFEEVVQELRMEQ 212
L+L +E E L+ EEL R++ EL ++N +E EK Q ++ V+EL+ +
Sbjct: 1071 LKLNRESMENLESSQRHLAEEL---RKKELELSQMNSKVENEKGLVAQLQKTVKELQTQI 1127
Query: 213 EQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLA 272
+ +K +LE +E+E+ +L L + LEE+ LE+ ++ E Q L
Sbjct: 1128 KDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLH 1187
Query: 273 NQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQA 332
E+ LH K + + E +++ ++ + LE+++ +
Sbjct: 1188 RDMEE----ATLHFETTSASLKKRH-ADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDD 1242
Query: 333 LQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEK 388
L ++++T K AE K+ E RL EA L + Q N K K
Sbjct: 1243 LLTRVEQMTRAKANAE-------KLCTLYEERLHEATAKLDKVTQLANDLAAQKTK 1291
Score = 54.3 bits (129), Expect = 3e-07
Identities = 67/323 (20%), Positives = 138/323 (42%), Gaps = 24/323 (7%)
Query: 167 LDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCL 226
L K E EE+ +E+ +L++ + E ++++ + L E+ + +L+ L
Sbjct: 851 LVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETL 910
Query: 227 KGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHS 286
VE++ + L L+ ++ELS + EE E + + A + L
Sbjct: 911 ANVEEQCEWLIKSKIQLEARVKELSERVE------EEEEINSELTARGRKLEDECFELKK 964
Query: 287 NLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQ 346
+ +E + + +EK E ++K E L E+ + ++ +Q + Q+ +
Sbjct: 965 EIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHM 1024
Query: 347 AERELKAEVKVRMDLERRLREAEGAL-----------RSLEQGLNSKVRNKEKEERMRAD 395
E +L + K + LE+++ E EGAL R L + + N+E E + +
Sbjct: 1025 EEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESS 1084
Query: 396 VSHL-----KRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWND 450
HL K+ E N+++E + ++ + + + T +IK + T+
Sbjct: 1085 QRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQT-QIKDLKEKLEAERTTRAK 1143
Query: 451 MKPSQSFMTSQLDANNMEELKEV 473
M+ ++ +T L A+ E L+EV
Sbjct: 1144 MERERADLTQDL-ADLNERLEEV 1165
Score = 50.1 bits (118), Expect = 5e-06
Identities = 58/298 (19%), Positives = 135/298 (45%), Gaps = 36/298 (12%)
Query: 123 EQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQRE 182
+ TQ L+E V + L ++ ++ L + Q + ++ ++L+E TE + L
Sbjct: 1671 DSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYT 1730
Query: 183 QREELERLNQVLEAE----KQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRH 238
Q L + LEA+ +++ EEVVQE + +E+ K+ A + +++++ + H
Sbjct: 1731 QNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAH 1790
Query: 239 LTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQL 298
L ++T E +E+ LQ ++EQ G ++++E ++++
Sbjct: 1791 L---------------ERTRENMEQTITDLQKRLAEAEQMALMGS-RKQIQKLESRVRE- 1833
Query: 299 LEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVR 358
LE +L E R +R ++ L+ ++ELT + ++ ++ L + ++ +
Sbjct: 1834 LEGELEGEIRRSAEAQRG-------------ARRLERCIKELTYQAEEDKKNL-SRMQTQ 1879
Query: 359 MD-LERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAK 415
MD L+ +++ + + E N + +K++ +V E + +++A+
Sbjct: 1880 MDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAR 1937
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 73.2 bits (178), Expect = 5e-13
Identities = 77/355 (21%), Positives = 164/355 (46%), Gaps = 42/355 (11%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVV 205
E IK LEA L++ K++ L L + QR+ +LE L + + +E+V
Sbjct: 729 EGQIKKLEADSLEVKASKEQALQDLQQ-------QRQLNTDLELRATELSKQLEMEKEIV 781
Query: 206 QELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENE 265
R++ ++ LE + L E+EK+ L+ E+L Q E I+ ++ ++
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ---ETKIQHEELNNRIQTTV 838
Query: 266 NHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRA----LEE 321
LQ + + E L + L +++K+ ++ + ++ ++ ++ +A LE+
Sbjct: 839 TELQKVKMEKE------ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 322 EREFYSSQSQA-LQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLN 380
+ Q Q ++N+L+E K+ E+E +A +++++L + L Q N
Sbjct: 893 TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ-------LIQAQN 945
Query: 381 SKVRNKEKEERMRADVSHLKRFFEECIRNAEL---EAKMPVIMKNSV--YIHKAATRRIK 435
+ +N+++E++++ +++ LK+ E+ + E E K+ V+ K + + + T+ +
Sbjct: 946 TLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQ 1005
Query: 436 SCRFHRRRSSTSWNDMKPSQ-SFMTSQLDANNME--------ELKEVAKRLSRDQ 481
+ + S N+ + SQ +F Q D E +LK V ++LS Q
Sbjct: 1006 ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ 1060
Score = 67.4 bits (163), Expect = 3e-11
Identities = 75/303 (24%), Positives = 128/303 (42%), Gaps = 34/303 (11%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEEL--CLQREQRE- 185
+ L+ S K Q G+A I LE +L + Q ++ ++E +EL L++E+
Sbjct: 867 DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEAS 926
Query: 186 -----ELERLNQVL----------EAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVE 230
EL + + L E E+QQ + + EL+ EQ K+++E LK
Sbjct: 927 HQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986
Query: 231 QEKKELRH-LTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE-----QPPPSGGL 284
+K EL + L + L Q +EL+ EK+K + +L+ N Q Q + +
Sbjct: 987 LQKTELENKLQQQLTQAAQELAAEKEK-ISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Query: 285 HSNLRQIEEKMQQLLEEKLLAEKRMKENEER--------SRALEEEREFYSSQSQALQNS 336
+L+ +EEK+ L +E L++ + N+ + LE++ Q Q +
Sbjct: 1046 RQDLKSVEEKLS-LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104
Query: 337 LQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADV 396
LQ++ EK E+EL E ++E E + L + L S KE D
Sbjct: 1105 LQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDA 1164
Query: 397 SHL 399
L
Sbjct: 1165 KQL 1167
Score = 65.9 bits (159), Expect = 8e-11
Identities = 72/311 (23%), Positives = 139/311 (44%), Gaps = 26/311 (8%)
Query: 115 LLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLME-E 173
L A+++ EQ +L++ G K L + KS E L L KE+++ K+ E
Sbjct: 504 LREAQNDLEQ-----VLRQIGDKDQKIQNLEALLQKSKENISL-LEKEREDLYAKIQAGE 557
Query: 174 TEELCLQREQ------REELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLK 227
E L + Q +E++ +L + L+ + + ++ + L + ++ K L +
Sbjct: 558 GETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVL 617
Query: 228 GVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENE-----------NHLQTLANQ-S 275
+E EL ++ + +L I+ K E+L E NHL T N
Sbjct: 618 SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQ 677
Query: 276 EQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQN 335
++ + + L Q+ K+Q E E +KE +E+ +LE++ E Q + L+
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737
Query: 336 SLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNS-KVRNKEKEERMRA 394
E+ A K+QA ++L+ + ++ DLE R E L ++ ++S ++ ++K E + +
Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES 797
Query: 395 DVSHLKRFFEE 405
L + EE
Sbjct: 798 IKQKLTKQEEE 808
Score = 58.2 bits (139), Expect = 2e-08
Identities = 80/374 (21%), Positives = 173/374 (46%), Gaps = 67/374 (17%)
Query: 153 EAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERL-NQVLEAEKQQFEEVVQELRME 211
E GLQL E + KL+E +L + +E +L ++ L ++QQ ++ +L
Sbjct: 406 EQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465
Query: 212 QEQIKREL----ELTARCLKGVEQEKKE----------LRHLTESLQQTLEELSIEKKK- 256
+EQ+K ++ EL + K +Q +++ LR L+Q L ++ + +K
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 525
Query: 257 -TLE-MLEENENHLQTLANQSE----QPPPSGGLHSNLRQIEEKMQQLLEE-KLLAEKRM 309
LE +L++++ ++ L + E + G + L Q++EK L E+ L EK
Sbjct: 526 QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK 585
Query: 310 KENEERSRALE------EEREFYSSQSQ----ALQNSLQELTAEKQQAER-------ELK 352
++E +A E +E++ + +Q +L+ S+ EL ++ +++ ++K
Sbjct: 586 NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
Query: 353 AEVKV-----------RMDLERRLREAEGALRSLEQGLNS--------KVRNKEKEERMR 393
A+ ++ R DL+ L A+ AL+ +Q LN + ++K+E
Sbjct: 646 AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705
Query: 394 ADVSHLKRFFEECI----RNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWN 449
SHLK + E+ + + ELE ++ + +S+ + + + ++ + R+ ++
Sbjct: 706 QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT---- 761
Query: 450 DMKPSQSFMTSQLD 463
D++ + ++ QL+
Sbjct: 762 DLELRATELSKQLE 775
Score = 57.0 bits (136), Expect = 4e-08
Identities = 63/275 (22%), Positives = 130/275 (47%), Gaps = 29/275 (10%)
Query: 152 LEAQGLQLAKEKQEYLDKLMEETEELCLQREQR-EELERLNQVLEAEKQQFEEVVQELRM 210
L+ G++ ++ L ++ + + L+RE+ E+L+ + L+++ E + +LR
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRS 274
Query: 211 EQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQT 270
E + +E+ A ++ +++ K + LT+ QTL E ++K++ LEE N
Sbjct: 275 ELAKGPQEV---AVYVQELQKLKSSVNELTQK-NQTLTENLLKKEQDYTKLEEKHN---- 326
Query: 271 LANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEK-------RMKENEERSRALEEER 323
E+ + + L Q + QQL +E + E E ++ L+EE
Sbjct: 327 -----EESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL 381
Query: 324 EFYSSQSQALQ---NSLQELTAEKQQAERELKAEVKVR----MDLERRLREAEGALRSLE 376
++ Q L+ LQ+ EK+Q +L++E+ ++ ER+L EA G L+
Sbjct: 382 SEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 441
Query: 377 QGLNSKVRNKEKE-ERMRADVSHLKRFFEECIRNA 410
Q + K+ +KE++ ++ +S L+ +E + N+
Sbjct: 442 QLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNS 476
Score = 56.6 bits (135), Expect = 5e-08
Identities = 85/385 (22%), Positives = 170/385 (44%), Gaps = 37/385 (9%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETE 175
L++E ++ Q + LQ K++ QL E + S E Q QL K KQ++ ++ +
Sbjct: 443 LSSEKLMDKEQQVADLQL--KLSRLEEQLKEKVTNSTELQH-QLDKTKQQHQEQQALQQS 499
Query: 176 ELCLQREQREELER-LNQV---------LEAEKQQFEEVVQELRMEQEQIKRELELTARC 225
RE + +LE+ L Q+ LEA Q+ +E + L E+E + +++
Sbjct: 500 TTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE 559
Query: 226 LKGVEQEKKELRHLTESLQQTLEELSIE-------KKKTLEMLEENENHLQTLANQSEQP 278
+ Q +++ L E + Q E+L + ++ + ++E + HL+ ++
Sbjct: 560 TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 619
Query: 279 PPS-GGLHSNLRQIEEKMQQL-LEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
S L+S L + +EK+ QL ++ K E + ++ + + + ALQ+
Sbjct: 620 ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
Query: 337 LQEL---TAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKE-ERM 392
QEL T + Q +L+ + + LE L+E + SLEQ K E + +++
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ----KTEELEGQIKKL 735
Query: 393 RADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRR-RSSTSWNDM 451
AD +K E+ +++ + + ++ + + AT K + SST +
Sbjct: 736 EADSLEVKASKEQALQDLQQQRQL------NTDLELRATELSKQLEMEKEIVSSTRLDLQ 789
Query: 452 KPSQSFMTSQLDANNMEELKEVAKR 476
K S++ + + EE K++ K+
Sbjct: 790 KKSEALESIKQKLTKQEEEKQILKQ 814
Score = 56.2 bits (134), Expect = 7e-08
Identities = 76/349 (21%), Positives = 151/349 (43%), Gaps = 40/349 (11%)
Query: 131 LQESGKVTWK-NAQLGEAMIK--SLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREEL 187
L E G+ T K +L E K L+A+ QL ++++E ++ E+ + E
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
Query: 188 ERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEK----KELRHLTESL 243
ER ++ ++ E M++EQ +L+L L+ +EK EL+H +
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 244 QQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKL 303
+Q +E ++ T L E +N L+ + Q G ++ +E +Q+ E
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQ------IGDKDQKIQNLEALLQKSKENIS 540
Query: 304 LAEKRMKENEERSRALEEEREFYS---SQSQALQNSLQELTAE-KQQAERELKAEVKVRM 359
L EK ++ + +A E E + ++ LQ + +LT + K Q+E +A+ +
Sbjct: 541 LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
Query: 360 DLERR---LREAEGALRSLEQGLN--SKVRNKEKEERMRADVSHLKRFFEECIRNAELEA 414
++ + LR A+ + SLE +N + N+ KE+ + D+ +++A
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDI--------------QIKA 646
Query: 415 KMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLD 463
K +++ A T + + H + + D + + +T+QLD
Sbjct: 647 KTELLLS----AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD 691
Score = 54.3 bits (129), Expect = 3e-07
Identities = 53/263 (20%), Positives = 116/263 (44%), Gaps = 21/263 (7%)
Query: 158 QLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKR 217
+L E K TE L + + +LE + K+ + + + ++ +Q++
Sbjct: 292 KLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQS 351
Query: 218 ELELTARCLKGVEQEKKELRHLTESLQQTLEE-------LSIEKKKTLEMLEENENHLQT 270
L + L + E E T+ L++ L E L E K+ + EE E H
Sbjct: 352 RLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQ 411
Query: 271 LANQSEQPPPSGGLHSNL----RQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFY 326
L ++ Q LHS L RQ+ E +L E++ L+ +++ + E++ L+ +
Sbjct: 412 LQSEINQ------LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465
Query: 327 SSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGL---NSKV 383
Q + + EL + + +++ + + ++ +LREA+ L + + + + K+
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 525
Query: 384 RNKEK-EERMRADVSHLKRFFEE 405
+N E ++ + ++S L++ E+
Sbjct: 526 QNLEALLQKSKENISLLEKERED 548
Score = 51.2 bits (121), Expect = 2e-06
Identities = 71/332 (21%), Positives = 145/332 (43%), Gaps = 55/332 (16%)
Query: 108 QDFHGNILLAAESEFEQTQWLEMLQESGKVT-WKNAQLGEAMIKSLE--AQGLQLAKEKQ 164
Q GNI +S ++ + +E LQ K+ + +L + + L AQ L KEK
Sbjct: 955 QQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKI 1014
Query: 165 EYLDKLMEETEELCLQREQ------------REELERLNQVLEAEKQQF----------E 202
L E+++E Q + R++L+ + + L ++
Sbjct: 1015 SVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN 1074
Query: 203 EVVQELR-----MEQEQIKRELELTARC--LKGVEQEK----KELRHLTESLQQTLEELS 251
+++QEL+ +EQ+ K+E +L RC L+ +++EK KEL + L + E
Sbjct: 1075 KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKC 1134
Query: 252 IEKKKTLEMLEENENH-LQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMK 310
++K+ ++ EE ++H L+++ + +++ Q L+++KL + +
Sbjct: 1135 RQEKEITKLNEELKSHKLESI--------------KEITNLKDAKQLLIQQKLELQGKA- 1179
Query: 311 ENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEG 370
+ A+E+E+ ++ +EL E + E +L +E+K + ++ E E
Sbjct: 1180 --DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEA 1237
Query: 371 ALRSLEQGLNSKVRNKEKE-ERMRADVSHLKR 401
L LN + +KE + + VS L++
Sbjct: 1238 KLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269
Score = 50.1 bits (118), Expect = 5e-06
Identities = 58/271 (21%), Positives = 114/271 (42%), Gaps = 31/271 (11%)
Query: 146 EAMIKSLEA-QGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEV 204
E + K LE QGLQ + K + L + + + EL +Q EE + N ++ K FE+
Sbjct: 107 EELKKELEKYQGLQQQEAKPDGL--VTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQK 164
Query: 205 VQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEEN 264
+L E IK + + E R L E+ +Q + L+ E L +
Sbjct: 165 AAQLATEIADIKSKYD--------------EERSLREAAEQKVTRLT-------EELNKE 203
Query: 265 ENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEERE 324
+Q L + Q P + + ++L++ + L + E E S L++E +
Sbjct: 204 ATVIQDLKTELLQRP-------GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK 256
Query: 325 FYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVR 384
SQ + + ++ +L +E + +E+ V+ L+ + E ++L + L K +
Sbjct: 257 KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
Query: 385 NKEKEERMRADVSHLKRFFEECIRNAELEAK 415
+ K E + S K+ + + +L+ +
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
Score = 48.9 bits (115), Expect = 1e-05
Identities = 73/355 (20%), Positives = 151/355 (42%), Gaps = 31/355 (8%)
Query: 113 NILLAAESEFEQTQW-LEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLM 171
N L E E +Q Q + L++S + K + + +K Q +L + Q+ +L
Sbjct: 945 NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ---QLT 1001
Query: 172 EETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQ 231
+ +EL ++E+ VL+ ++ +E ++L+ + + EL T + LK VE+
Sbjct: 1002 QAAQELAAEKEK-------ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEE 1054
Query: 232 EKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQI 291
+L E L ++ + K E+ Q A + +Q L++
Sbjct: 1055 ---KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ----------LQER 1101
Query: 292 EEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAEREL 351
+ +Q + +EK L EK + + + L E E Q + + +EL + K ++ +E+
Sbjct: 1102 CKALQDIQKEKSLKEKELVNEKSK---LAEIEEIKCRQEKEITKLNEELKSHKLESIKEI 1158
Query: 352 KAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKE-KEERMRADVSHLKRFF--EECIR 408
+ L ++ E +G SL+ + + RN++ +++++ + LK+ F +E
Sbjct: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL 1218
Query: 409 NAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLD 463
++E++ K V MK T +I + + W + S + Q D
Sbjct: 1219 HSEIKEK-EVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
Score = 42.4 bits (98), Expect = 0.001
Identities = 62/301 (20%), Positives = 130/301 (43%), Gaps = 59/301 (19%)
Query: 109 DFHG--NILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEA--MIKSLEAQGLQLAKEKQ 164
DF+G + LLA + + + L + ++ +N Q+G +I+ L+ L ++
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLISNRN-QIGNQNKLIQELKTAKATLEQDSA 1092
Query: 165 EYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQ-ELRMEQEQIKRELELTA 223
+ +L E + LQ Q+E+ + +++ EK + E+ + + R E+E K EL +
Sbjct: 1093 KKEQQLQERCK--ALQDIQKEKSLKEKELVN-EKSKLAEIEEIKCRQEKEITKLNEELKS 1149
Query: 224 RCLKGVE-------------QEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQT 270
L+ ++ Q+K EL+ +SL+ +E ++K+ ++L++
Sbjct: 1150 HKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVE----QEKRNQQILKDQVK---- 1201
Query: 271 LANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQS 330
++ EE ++ +E++ +KE E + EE + Q
Sbjct: 1202 ------------------KEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI 1243
Query: 331 QALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEE 390
AL +L + E Q ++R + +LE++ + G + LE + V+N + E
Sbjct: 1244 TALNENLGTVKKEWQSSQRRVS-------ELEKQTDDLRGEIAVLE----ATVQNNQDER 1292
Query: 391 R 391
R
Sbjct: 1293 R 1293
Score = 31.2 bits (69), Expect = 2.3
Identities = 28/129 (21%), Positives = 60/129 (46%), Gaps = 8/129 (6%)
Query: 151 SLEAQGLQLAKEKQEYLDKLMEETEEL---CLQREQREELERLNQVLEAEKQQFEEV--- 204
SL+A Q + +Q D++ +E EEL +++E + E + + +K + E
Sbjct: 1181 SLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
Query: 205 --VQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLE 262
+ L +K+E + + R + +E++ +LR L+ T++ E++ LE
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCL 1300
Query: 263 ENENHLQTL 271
+ E ++ L
Sbjct: 1301 KGEGEIEKL 1309
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 72.8 bits (177), Expect = 7e-13
Identities = 75/347 (21%), Positives = 161/347 (46%), Gaps = 48/347 (13%)
Query: 132 QESGKVTWKNAQLGEAM---------IKSLEAQGLQLAKEKQEYLDKLMEETEELCLQRE 182
QE+ ++ +N +L + + ++SLE + QL +E E L E L
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE----LRRNVESLKCASM 718
Query: 183 QREELERLNQVLEAEKQQFEEVVQELR-----------------MEQEQIKRELELTARC 225
+ +L+ N+ LE+EK+Q ++ ++ L+ +E +++++ LE + +
Sbjct: 719 KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 226 LKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLH 285
++ +E E ++L ++LQ+ LEEL I K+ LE LE+ L+ +Q L
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKR-LEQLEKENKSLEQETSQ---------LE 828
Query: 286 SNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS---LQELTA 342
+ +Q+E++ ++L ++ + + ++EN + LE+E + S + + S L+EL
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK 888
Query: 343 EKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRF 402
E ++ + ++K + L L + + + L EK + + H ++
Sbjct: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948
Query: 403 FEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWN 449
++ R LE+K+ +K S+ I + +++ R ST++N
Sbjct: 949 TDDS-RYKLLESKLESTLKKSLEIKEEKIAALEA----RLEESTNYN 990
Score = 68.9 bits (167), Expect = 1e-11
Identities = 90/376 (23%), Positives = 162/376 (43%), Gaps = 41/376 (10%)
Query: 128 LEMLQESGKVTWKNAQLGEAMIKSLEAQG---LQLAKEKQEYLDKLMEETEELCLQREQR 184
+E L+E +V + + E ++ A+ +L KE + KL + E + R++
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405
Query: 185 EELERLNQVLE-AEKQQFEEVVQELRMEQEQIKR--EL-------------ELTARCLKG 228
EEL N LE A+KQ +E + L E EQI R EL ELT+ L
Sbjct: 406 EELMEENMTLEMAQKQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 229 VEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENE---NHLQTLANQSEQPPPSGGLH 285
+E E + L E L+ T++ + K L+M +EN+ ++ L N+ Q S
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS---- 520
Query: 286 SNLRQIEEKMQQLLEEKLLAEK---RMKENEERS-RALEEEREFYSSQSQAL-QNSLQEL 340
L+ + + L++EK EK ++EN ER + LE+E E + +L Q S
Sbjct: 521 --LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA 578
Query: 341 TAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLK 400
A + E+E K + + +L + E R +++ L E+ E + ++ HL+
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 401 R---FFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSF 457
+ ++ I N ++ + ++ + R++K + + ++
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE--- 695
Query: 458 MTSQLDANNMEELKEV 473
SQLD N+E + V
Sbjct: 696 -NSQLDEENLELRRNV 710
Score = 61.6 bits (148), Expect = 2e-09
Identities = 94/409 (22%), Positives = 185/409 (45%), Gaps = 51/409 (12%)
Query: 119 ESEFE----QTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEET 174
ESE + + Q L+ E K++ K + E KSLE + QL K+K++ L +E
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ----LEKEN 838
Query: 175 EELCLQREQRE-ELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEK 233
+ L Q E ++ LE N + +++ + + +E+ + +E R LK +E+E
Sbjct: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVR--------LKELEKEN 890
Query: 234 KEL-RHLT---ESLQQTLEELSIEKKKTLEM---LEENENHLQTLANQSEQPPPSGGLHS 286
KEL + T ++L E+L EK KT +M LE+ + L+ + E+ L
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER------LLH 944
Query: 287 NLRQIEEKMQQLLEEKL--LAEKRMKENEERSRALEEEREFYSSQSQALQNSLQ------ 338
+ + ++ +LLE KL +K ++ EE+ ALE E ++ +Q L+ L+
Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY 1004
Query: 339 ELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSH 398
E ++Q ER +++ + + + RE++ R L + + + + ++A+
Sbjct: 1005 EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA 1064
Query: 399 LKRFFEEC-IRNAELEAKMPVIMKNSVYIHKA-ATRRIKSCRFHRRRS-----STSWNDM 451
LK ++ +N L+A++ + + +V + + T + ++ + S STS +
Sbjct: 1065 LKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1124
Query: 452 KPSQSFMTSQLDANN------MEELKEVAKRLSRDQRFRESIYHIMATQ 494
S L+ N E+LK + L +D E ++ A++
Sbjct: 1125 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1173
Score = 52.4 bits (124), Expect = 1e-06
Identities = 71/367 (19%), Positives = 159/367 (43%), Gaps = 31/367 (8%)
Query: 90 LVEPKEEPSMPYAMKISHQDFHGNILLAAESEFEQ-TQWLEMLQESGKVTWKN------A 142
L+E K E ++ +++I + + A E+ E+ T + + L++ K KN
Sbjct: 956 LLESKLESTLKKSLEIKEEK-----IAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1010
Query: 143 QLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFE 202
Q E M++S ++ E ++ + E T EL +++ E+ER N L+AEKQ +
Sbjct: 1011 QDEERMVQSSPP----ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1066
Query: 203 EVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLE 262
+++L + ++ ++ R ++++ L+ T++ + +E ++ + T M +
Sbjct: 1067 TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ--TQNAKLQVENSTLNSQSTSLMNQ 1124
Query: 263 ENENHLQ--TLANQSE----QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERS 316
+ +Q +L N++E + L+ +L + EK++ L E + + +
Sbjct: 1125 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184
Query: 317 RALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLE 376
++ + E + N L + + + E+ LK E + +M LE + E A
Sbjct: 1185 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE-QEKMLLENKNHETVAAEYKKL 1243
Query: 377 QGLNSKVRNK-----EKEERMRADVSHLKRFFEEC-IRNAELEAKMPVIMKNSVYIHKAA 430
G N ++ + ++ E ++ D +LK + LEA+ + + + +
Sbjct: 1244 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1303
Query: 431 TRRIKSC 437
T+ C
Sbjct: 1304 TKLNNQC 1310
Score = 48.5 bits (114), Expect = 1e-05
Identities = 81/366 (22%), Positives = 149/366 (40%), Gaps = 64/366 (17%)
Query: 115 LLAAESEFEQTQW-LEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEE 173
LL + E EQ + L+ LQ+ +A+ L+A +EK +DKL E
Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-----LREKAVRVDKLESE 328
Query: 174 TE-------ELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCL 226
++ + + EEL+ NQVL K E+ ++ R +++ ELE
Sbjct: 329 VSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL-HELE------ 381
Query: 227 KGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQS----------- 275
KE L L E +++KK E++EEN L+ QS
Sbjct: 382 -------KENLQLKAKLHDMEMERDMDRKKIEELMEENMT-LEMAQKQSMDESLHLGWEL 433
Query: 276 EQPPPSGGL-HSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSS------ 328
EQ + L + + + ++ +L +LL K EN+ ++ +EE R S
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLL--KLEMENQSLTKTVEELRTTVDSVEGNAS 491
Query: 329 -------QSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNS 381
++Q L ++ L E Q ++ L+ + DL + + E + +L +
Sbjct: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
Query: 382 KVRNKEKE-ERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIH---KAATRRIKSC 437
+++ E+E E + VS L++ + EA++ I K + +H K + ++
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQ-----ISAEARVKDIEKENKILHESIKETSSKLSKI 606
Query: 438 RFHRRR 443
F +R+
Sbjct: 607 EFEKRQ 612
Score = 47.0 bits (110), Expect = 4e-05
Identities = 72/321 (22%), Positives = 134/321 (41%), Gaps = 46/321 (14%)
Query: 48 SRRFFIIKESFLLYYSESEKKSFETNKYFNIHPKGVIPLGGCLVEPKEEPSMPYAMKISH 107
S+ I KES + E EK++ E K I K ++ L LV K +
Sbjct: 870 SKEIGIYKES-CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK----------LKT 918
Query: 108 QDFHGNI-LLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEY 166
Q + ++ L E E +L + +L E+ ++S + L++ +EK
Sbjct: 919 QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAA 978
Query: 167 LDKLMEETEELCLQREQREELERLNQVLEA--EKQQFEEVVQE---LRMEQEQIKRELEL 221
L+ +EE+ ++ R+EL+ + + EA ++Q E +VQ + E + +RE +
Sbjct: 979 LEARLEESTNY--NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQE 1036
Query: 222 TARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPS 281
T R L V+ E+ +LQ + L K L+ LE N+LQ
Sbjct: 1037 TTRELLKVKDRLIEVERNNATLQAEKQAL----KTQLKQLETQNNNLQA----------- 1081
Query: 282 GGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELT 341
++ L + + +++ + ++ L+ E +SQS +L N +L
Sbjct: 1082 ------------QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1129
Query: 342 AEKQQAERELKAEVKVRMDLE 362
++ E E ++ +K R DL+
Sbjct: 1130 IQQSSLENENESVIKEREDLK 1150
Score = 45.1 bits (105), Expect = 2e-04
Identities = 59/265 (22%), Positives = 108/265 (40%), Gaps = 46/265 (17%)
Query: 169 KLMEETEELCLQ-REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKR---------- 217
K E + L ++ + + ++ RL Q LE + +Q + QEL + ++KR
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 218 --------ELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQ 269
EL A K V +K E ++ L ++ K + E+ E+N+ L+
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESE--VSRYKERLHDIEFYKARVEELKEDNQVLLE 358
Query: 270 TLANQSEQPPPSGGLHSNLRQIE---------------------EKMQQLLEEKLLAEKR 308
T +Q + L ++E +K+++L+EE + E
Sbjct: 359 TKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 309 MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQ--AERELKAEVKVRMDLERRLR 366
K++ + S L E E S S+ + + L E + + R LK E++ L + +
Sbjct: 419 QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME-NQSLTKTVE 477
Query: 367 EAEGALRSLEQGLNSKVRNKEKEER 391
E + S+E G SK+ EKE +
Sbjct: 478 ELRTTVDSVE-GNASKILKMEKENQ 501
Score = 39.3 bits (90), Expect = 0.009
Identities = 49/216 (22%), Positives = 95/216 (43%), Gaps = 34/216 (15%)
Query: 103 MKISHQDFHG--NILLAAESEFEQTQ-WLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQL 159
+++ H+D N LL + + E + L++ QE + KN + A K L + +L
Sbjct: 1191 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRL 1250
Query: 160 AKEKQEYLDKLMEETEELCLQREQREEL---ERLNQV-LEAEKQQFEEVVQELRMEQEQI 215
+L++ETE L + + L +L Q LEAE + +E Q+L + ++
Sbjct: 1251 ----NHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1306
Query: 216 KRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQS 275
+ EL ++ +E+E RHL + +Q L ++ + LE E+++
Sbjct: 1307 NNQCELLSQLKGNLEEEN---RHLLDQIQ----TLMLQNRTLLEQNMESKDL-------- 1351
Query: 276 EQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKE 311
H RQ +K+ +L +K E+++ +
Sbjct: 1352 --------FHVEQRQYIDKLNELRRQKEKLEEKIMD 1379
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 72.8 bits (177), Expect = 7e-13
Identities = 75/347 (21%), Positives = 161/347 (46%), Gaps = 49/347 (14%)
Query: 132 QESGKVTWKNAQLGEAM---------IKSLEAQGLQLAKEKQEYLDKLMEETEELCLQRE 182
QE+ ++ +N +L + + ++SLE + QL +E E L E L
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE----LRRNVESLKCASM 718
Query: 183 QREELERLNQVLEAEKQQFEEVVQELR-----------------MEQEQIKRELELTARC 225
+ +L+ N+ LE+EK+Q ++ ++ L+ +E +++++ LE + +
Sbjct: 719 KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 226 LKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLH 285
++ +E E ++L ++LQ+ LEEL I K+ LE LE+ L+ +Q L
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKR-LEQLEKENKSLEQETSQ---------LE 828
Query: 286 SNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS---LQELTA 342
+ +Q+E++ ++L ++ + + ++EN + LE+E + S + + S L+EL
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK 888
Query: 343 EKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRF 402
E ++ + ++K + L L + + + L EK + + H ++
Sbjct: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948
Query: 403 FEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWN 449
++ R LE+K+ +K S+ I + +++ R ST++N
Sbjct: 949 TDD--RYKLLESKLESTLKKSLEIKEEKIAALEA----RLEESTNYN 989
Score = 68.9 bits (167), Expect = 1e-11
Identities = 90/376 (23%), Positives = 162/376 (43%), Gaps = 41/376 (10%)
Query: 128 LEMLQESGKVTWKNAQLGEAMIKSLEAQG---LQLAKEKQEYLDKLMEETEELCLQREQR 184
+E L+E +V + + E ++ A+ +L KE + KL + E + R++
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405
Query: 185 EELERLNQVLE-AEKQQFEEVVQELRMEQEQIKR--EL-------------ELTARCLKG 228
EEL N LE A+KQ +E + L E EQI R EL ELT+ L
Sbjct: 406 EELMEENMTLEMAQKQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 229 VEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENE---NHLQTLANQSEQPPPSGGLH 285
+E E + L E L+ T++ + K L+M +EN+ ++ L N+ Q S
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS---- 520
Query: 286 SNLRQIEEKMQQLLEEKLLAEK---RMKENEERS-RALEEEREFYSSQSQAL-QNSLQEL 340
L+ + + L++EK EK ++EN ER + LE+E E + +L Q S
Sbjct: 521 --LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA 578
Query: 341 TAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLK 400
A + E+E K + + +L + E R +++ L E+ E + ++ HL+
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 401 R---FFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSF 457
+ ++ I N ++ + ++ + R++K + + ++
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE--- 695
Query: 458 MTSQLDANNMEELKEV 473
SQLD N+E + V
Sbjct: 696 -NSQLDEENLELRRNV 710
Score = 61.6 bits (148), Expect = 2e-09
Identities = 94/406 (23%), Positives = 183/406 (45%), Gaps = 46/406 (11%)
Query: 119 ESEFE----QTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEET 174
ESE + + Q L+ E K++ K + E KSLE + QL K+K++ L +E
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ----LEKEN 838
Query: 175 EELCLQREQRE-ELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEK 233
+ L Q E ++ LE N + +++ + + +E+ + +E R LK +E+E
Sbjct: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVR--------LKELEKEN 890
Query: 234 KEL-RHLT---ESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLR 289
KEL + T ++L E+L EK KT +M N L+ L ++ E+ + +
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQM----NNDLEKLTHELEKIGLNKERLLHDE 946
Query: 290 QIEEKMQQLLEEKL--LAEKRMKENEERSRALEEEREFYSSQSQALQNSLQ------ELT 341
Q + +LLE KL +K ++ EE+ ALE E ++ +Q L+ L+ E
Sbjct: 947 QSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1006
Query: 342 AEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKR 401
++Q ER +++ + + + RE++ R L + + + + ++A+ LK
Sbjct: 1007 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKT 1066
Query: 402 FFEEC-IRNAELEAKMPVIMKNSVYIHKA-ATRRIKSCRFHRRRS-----STSWNDMKPS 454
++ +N L+A++ + + +V + + T + ++ + S STS +
Sbjct: 1067 QLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1126
Query: 455 QSFMTSQLDANN------MEELKEVAKRLSRDQRFRESIYHIMATQ 494
S L+ N E+LK + L +D E ++ A++
Sbjct: 1127 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1172
Score = 52.4 bits (124), Expect = 1e-06
Identities = 71/367 (19%), Positives = 159/367 (43%), Gaps = 31/367 (8%)
Query: 90 LVEPKEEPSMPYAMKISHQDFHGNILLAAESEFEQ-TQWLEMLQESGKVTWKN------A 142
L+E K E ++ +++I + + A E+ E+ T + + L++ K KN
Sbjct: 955 LLESKLESTLKKSLEIKEEK-----IAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009
Query: 143 QLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFE 202
Q E M++S ++ E ++ + E T EL +++ E+ER N L+AEKQ +
Sbjct: 1010 QDEERMVQSSPP----ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1065
Query: 203 EVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLE 262
+++L + ++ ++ R ++++ L+ T++ + +E ++ + T M +
Sbjct: 1066 TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ--TQNAKLQVENSTLNSQSTSLMNQ 1123
Query: 263 ENENHLQ--TLANQSE----QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERS 316
+ +Q +L N++E + L+ +L + EK++ L E + + +
Sbjct: 1124 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1183
Query: 317 RALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLE 376
++ + E + N L + + + E+ LK E + +M LE + E A
Sbjct: 1184 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE-QEKMLLENKNHETVAAEYKKL 1242
Query: 377 QGLNSKVRNK-----EKEERMRADVSHLKRFFEEC-IRNAELEAKMPVIMKNSVYIHKAA 430
G N ++ + ++ E ++ D +LK + LEA+ + + + +
Sbjct: 1243 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1302
Query: 431 TRRIKSC 437
T+ C
Sbjct: 1303 TKLNNQC 1309
Score = 48.5 bits (114), Expect = 1e-05
Identities = 81/366 (22%), Positives = 149/366 (40%), Gaps = 64/366 (17%)
Query: 115 LLAAESEFEQTQW-LEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEE 173
LL + E EQ + L+ LQ+ +A+ L+A +EK +DKL E
Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-----LREKAVRVDKLESE 328
Query: 174 TE-------ELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCL 226
++ + + EEL+ NQVL K E+ ++ R +++ ELE
Sbjct: 329 VSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL-HELE------ 381
Query: 227 KGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQS----------- 275
KE L L E +++KK E++EEN L+ QS
Sbjct: 382 -------KENLQLKAKLHDMEMERDMDRKKIEELMEENMT-LEMAQKQSMDESLHLGWEL 433
Query: 276 EQPPPSGGL-HSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSS------ 328
EQ + L + + + ++ +L +LL K EN+ ++ +EE R S
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLL--KLEMENQSLTKTVEELRTTVDSVEGNAS 491
Query: 329 -------QSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNS 381
++Q L ++ L E Q ++ L+ + DL + + E + +L +
Sbjct: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
Query: 382 KVRNKEKE-ERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIH---KAATRRIKSC 437
+++ E+E E + VS L++ + EA++ I K + +H K + ++
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQ-----ISAEARVKDIEKENKILHESIKETSSKLSKI 606
Query: 438 RFHRRR 443
F +R+
Sbjct: 607 EFEKRQ 612
Score = 45.1 bits (105), Expect = 2e-04
Identities = 59/265 (22%), Positives = 108/265 (40%), Gaps = 46/265 (17%)
Query: 169 KLMEETEELCLQ-REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKR---------- 217
K E + L ++ + + ++ RL Q LE + +Q + QEL + ++KR
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 218 --------ELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQ 269
EL A K V +K E ++ L ++ K + E+ E+N+ L+
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESE--VSRYKERLHDIEFYKARVEELKEDNQVLLE 358
Query: 270 TLANQSEQPPPSGGLHSNLRQIE---------------------EKMQQLLEEKLLAEKR 308
T +Q + L ++E +K+++L+EE + E
Sbjct: 359 TKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 309 MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQ--AERELKAEVKVRMDLERRLR 366
K++ + S L E E S S+ + + L E + + R LK E++ L + +
Sbjct: 419 QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME-NQSLTKTVE 477
Query: 367 EAEGALRSLEQGLNSKVRNKEKEER 391
E + S+E G SK+ EKE +
Sbjct: 478 ELRTTVDSVE-GNASKILKMEKENQ 501
Score = 39.3 bits (90), Expect = 0.009
Identities = 49/216 (22%), Positives = 95/216 (43%), Gaps = 34/216 (15%)
Query: 103 MKISHQDFHG--NILLAAESEFEQTQ-WLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQL 159
+++ H+D N LL + + E + L++ QE + KN + A K L + +L
Sbjct: 1190 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRL 1249
Query: 160 AKEKQEYLDKLMEETEELCLQREQREEL---ERLNQV-LEAEKQQFEEVVQELRMEQEQI 215
+L++ETE L + + L +L Q LEAE + +E Q+L + ++
Sbjct: 1250 ----NHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1305
Query: 216 KRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQS 275
+ EL ++ +E+E RHL + +Q L ++ + LE E+++
Sbjct: 1306 NNQCELLSQLKGNLEEEN---RHLLDQIQ----TLMLQNRTLLEQNMESKDL-------- 1350
Query: 276 EQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKE 311
H RQ +K+ +L +K E+++ +
Sbjct: 1351 --------FHVEQRQYIDKLNELRRQKEKLEEKIMD 1378
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 72.8 bits (177), Expect = 7e-13
Identities = 84/354 (23%), Positives = 146/354 (41%), Gaps = 28/354 (7%)
Query: 140 KNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQ 199
K A + E + + Q L +AKE+QE L + E E L+ +EE+ +Q ++ K+
Sbjct: 725 KGALIEELLQAKQDLQDLLIAKEEQEDLLR-KRERELTALKGALKEEVSSHDQEMDKLKE 783
Query: 200 QFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLE 259
Q++ +Q LR E+ + +E+ A EQ++ + LQ+ E +K
Sbjct: 784 QYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQE-------ENEKLQG 836
Query: 260 MLEENENHLQTLANQSEQ-PPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRA 318
EE E + L Q E L++ E +++QL E + A K KE RA
Sbjct: 837 RSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRA 896
Query: 319 LEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQG 378
LE E E A Q +L + T E++Q +LK E + + L R E E L +
Sbjct: 897 LENELE-------AAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949
Query: 379 LNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCR 438
+ EK ++ AD+ R EL+ ++ + + R++K
Sbjct: 950 I-------EKLQKEMADIVEASR-----TSTLELQNQLDEYKEKNRRELAEMQRQLKEKT 997
Query: 439 FHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKEVAKRLSRDQRFRESIYHIMA 492
+S + M+ M +L + + + KR +Q ++ Y + A
Sbjct: 998 LEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA 1051
Score = 70.5 bits (171), Expect = 3e-12
Identities = 104/423 (24%), Positives = 176/423 (41%), Gaps = 59/423 (13%)
Query: 108 QDFHGNILLAAES----EFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEA-QG--LQLA 160
+D G+ A E+ E E Q E L + K + A+ LEA QG Q
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTT 912
Query: 161 KEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELE 220
+E+++ +KL EE+E Q+E+L RL +E E+ + +++L+ E I
Sbjct: 913 QEQKQLSEKLKEESE-------QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 965
Query: 221 LTARCLKGV--EQEKKELRHLTESLQQTLEE-LSIEKKKTLEMLEENENHLQTLANQSEQ 277
+ L+ E ++K R L E +Q E+ L EK + M ++E L + Q
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
Query: 278 PPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKEN--------EERSRALEEEREFYSSQ 329
L RQ+ E+ + LE +L A+ +K++ E++ LE E E +
Sbjct: 1026 RAQDEALTK--RQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNN 1083
Query: 330 SQALQNSLQELTAEKQQAERELKAEVKVRMDLE--------------RRLREAEGALRSL 375
S L + + +Q EL E R DLE R+ EG+ RS
Sbjct: 1084 SDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSS 1143
Query: 376 EQGLNSKVRNK--------EKEERMRADVS----HLKRFFEECIRNAELEAKMPVIMKNS 423
++GL ++ + E EER RA++ L+R +E + + E K+
Sbjct: 1144 KEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQ 1203
Query: 424 VYIH-KAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKEVAKRLSRDQR 482
+ + KA R+++ R +S K Q + Q+D N E L+ + +D R
Sbjct: 1204 LSLRLKAMKRQVEEAEEEIDRLESS---KKKLQRELEEQMDMN--EHLQGQLNSMKKDLR 1258
Query: 483 FRE 485
++
Sbjct: 1259 LKK 1261
Score = 67.0 bits (162), Expect = 4e-11
Identities = 64/267 (23%), Positives = 125/267 (46%), Gaps = 18/267 (6%)
Query: 142 AQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQF 201
AQL + I+ L+ + + ++Y ++ + E L R++ +E + LE E +
Sbjct: 846 AQL-QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904
Query: 202 EEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEML 261
+ + + EQ+Q+ +L+ + + + + K E+ + L +T+E+L +K+ +++
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKL---QKEMADIV 961
Query: 262 EENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEK----RMKENEERSR 317
E + L NQ ++ N R++ E +QL E+ L AEK MK +E
Sbjct: 962 EASRTSTLELQNQLDEYK-----EKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRL 1016
Query: 318 ALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQ 377
EE R++ +Q +AL Q L + E EL+A+ ++ D R +++ E + LE
Sbjct: 1017 MEEELRDYQRAQDEAL-TKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEM 1075
Query: 378 GLNSKVRN----KEKEERMRADVSHLK 400
L + N E+ R R + L+
Sbjct: 1076 ELEEERNNSDLLSERISRSREQMEQLR 1102
Score = 63.5 bits (153), Expect = 4e-10
Identities = 70/284 (24%), Positives = 128/284 (45%), Gaps = 28/284 (9%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELE 188
++L++ K+T + A+L + LE + Q KE++E + +EE E+ EE
Sbjct: 611 DLLEQKSKLTIEVAELQRQL--QLEVKNQQNIKEERERMRANLEELRSQ--HNEKVEENS 666
Query: 189 RLNQVLEAEKQQFEEVVQEL---RMEQEQIKREL--------ELTARCLKGVEQEKKELR 237
L Q LE + + + ++EL +ME+EQ + E+ E+ E +E
Sbjct: 667 TLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKG 726
Query: 238 HLTESL---QQTLEELSIEKKKTLEMLEENENHLQTL--ANQSEQPPPSGGLHSNLRQIE 292
L E L +Q L++L I K++ ++L + E L L A + E + Q +
Sbjct: 727 ALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD 786
Query: 293 EKMQQLLEEKLLAEKRMKENEERSRALEEER-------EFYSSQSQALQNSLQELTAEKQ 345
++Q L E A K ++ RS E+++ + +++ LQ +EL
Sbjct: 787 AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVA 846
Query: 346 QAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKE 389
Q +R+++ + L++ EG +R LE+ L R +EKE
Sbjct: 847 QLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL-VHARKEEKE 889
Score = 52.8 bits (125), Expect = 7e-07
Identities = 63/286 (22%), Positives = 124/286 (43%), Gaps = 47/286 (16%)
Query: 159 LAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRE 218
L K +QE + EET + L N + E + +++ + E+I+
Sbjct: 539 LLKGQQELTQQTNEETAKQILY----------NYLKEGSTDNDDATKRKVNLVFEKIQTL 588
Query: 219 LELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQP 278
A +G Q + + L+Q +L+IE + L+ + Q + + E+
Sbjct: 589 KSRAAGSAQGNNQACNSTSEVKDLLEQK-SKLTIEVAELQRQLQLEVKNQQNIKEERER- 646
Query: 279 PPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENE-ERSRALEE------EREFYSSQSQ 331
+ +NL ++ + + +EE ++R++E+E E + LEE ERE + ++ +
Sbjct: 647 -----MRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIR 701
Query: 332 ALQNSLQE------------------LTAEKQQAERELKAEVKVRMDLERRLREAEGALR 373
LQ+ L E L E QA+++L+ + + + E LR+ E L
Sbjct: 702 DLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELT 761
Query: 374 SLEQGLNSKVRNKEKE-----ERMRADVSHLKRFFEECIRNAELEA 414
+L+ L +V + ++E E+ A++ L+ EE +N E+ A
Sbjct: 762 ALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLA 807
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 72.4 bits (176), Expect = 9e-13
Identities = 80/314 (25%), Positives = 149/314 (47%), Gaps = 42/314 (13%)
Query: 114 ILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEE 173
+L +AE+E E M +E G++ + + EA K LE + + L +EK + ++ E
Sbjct: 841 LLKSAETEKEMAT---MKEEFGRIK-ETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 896
Query: 174 ------TEELCLQ---------------REQREELERLNQVLEAEKQQFEEVVQELRMEQ 212
EE C Q E+ E+ E +N L A+K++ E+ EL+ +
Sbjct: 897 QDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDI 956
Query: 213 EQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELS-IEKKKTLEMLEENENHLQTL 271
+ +LELT L VE+EK + ++L + + L I K T E E H Q L
Sbjct: 957 D----DLELT---LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL 1009
Query: 272 ANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERS-RALEEEREFYSSQS 330
+ + L + ++E+++ L E L EK+++ + ER+ R LE + +
Sbjct: 1010 DDLQVEEDKVNSLSKSKVKLEQQVDDL-EGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068
Query: 331 QALQNS---LQELTAEKQ----QAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKV 383
L+N L+E +K+ Q +++ E + + L+++L+E + + LE+ L ++
Sbjct: 1069 MDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAER 1128
Query: 384 RNKEKEERMRADVS 397
+ K E++R+D+S
Sbjct: 1129 TARAKVEKLRSDLS 1142
Score = 62.8 bits (151), Expect = 7e-10
Identities = 77/386 (19%), Positives = 155/386 (40%), Gaps = 29/386 (7%)
Query: 94 KEEPSMPYAMKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLE 153
++E + ++ + + G++ L ES + L+E K + + I+ +
Sbjct: 1041 EQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQ 1100
Query: 154 AQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQE 213
LQL K+ +E ++ E EEL +R R ++E+L L E EE+ + L
Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRE---LEEISERLEEAGG 1157
Query: 214 QIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLAN 273
++E+ + ++ +++L T + T L + ++ L E ++LQ +
Sbjct: 1158 ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQ 1217
Query: 274 QSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQAL 333
+ E+ L L + M+Q+++ K EK SR LE++ Y + +
Sbjct: 1218 KLEKEKSEFKL--ELDDVTSNMEQIIKAKANLEK-------VSRTLEDQANEYRVKLEEA 1268
Query: 334 QNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMR 393
Q SL + T ++ + + E +L R+L E E + L +G S + E +R
Sbjct: 1269 QRSLNDFTTQRAKLQTE-------NGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL 1321
Query: 394 ADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKP 453
+ K +++A + + KA +R+ S W
Sbjct: 1322 EEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS---KANSEVAQWRTKYE 1378
Query: 454 SQSFMTSQLDANNMEELKEVAKRLSR 479
+ + + EEL+E K+L++
Sbjct: 1379 TDAIQRT-------EELEEAKKKLAQ 1397
Score = 60.8 bits (146), Expect = 3e-09
Identities = 80/301 (26%), Positives = 125/301 (41%), Gaps = 60/301 (19%)
Query: 129 EMLQESGKVTWKNAQLG-------EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQR 181
E L+E+G T ++ + M + LE LQ K + EL
Sbjct: 1150 ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL---G 1206
Query: 182 EQREELERLNQVLEAEKQQFEEVVQELRMEQEQI---KRELELTARCLKGVEQEKKELRH 238
EQ + L+R+ Q LE EK +F+ + ++ EQI K LE +R L E + E R
Sbjct: 1207 EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL---EDQANEYRV 1263
Query: 239 LTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQL 298
E Q++L + + ++ K LQT +G L L + E + QL
Sbjct: 1264 KLEEAQRSLNDFTTQRAK-----------LQT---------ENGELARQLEEKEALISQL 1303
Query: 299 LEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQ--ELTAEKQQAERELKAEV- 355
KL ++M E+ R LEEE + ++ + ALQ++ +L E+ + E E KAE+
Sbjct: 1304 TRGKLSYTQQM---EDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1360
Query: 356 ---------------KVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLK 400
K D +R E E A + L Q L +E E + A S L+
Sbjct: 1361 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA---EEAVEAVNAKCSSLE 1417
Query: 401 R 401
+
Sbjct: 1418 K 1418
Score = 60.8 bits (146), Expect = 3e-09
Identities = 82/382 (21%), Positives = 169/382 (44%), Gaps = 71/382 (18%)
Query: 121 EFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQ 180
E + Q E L+E+ K + Q E ++++ A+ L K K +L E E+L +
Sbjct: 1378 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKH----RLQNEIEDLMV- 1432
Query: 181 REQREELERLNQV---LEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELR 237
++ER N L+ +++ F++++ E + + E+ + ELE
Sbjct: 1433 -----DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELE----------------- 1470
Query: 238 HLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQ 297
S Q+ LS E K EE+ HL+T ++ + ++E++
Sbjct: 1471 ----SSQKEARSLSTELFKLKNAYEESLEHLETFKREN-------------KNLQEEISD 1513
Query: 298 LLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAE-RELKAEV- 355
L E+ K + E E+ + LE E+ LQ++L+E A + E + L+A++
Sbjct: 1514 LTEQLGEGGKNVHELEKVRKQLEVEK-------LELQSALEEAEASLEHEEGKILRAQLE 1566
Query: 356 --KVRMDLERRL----REAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRN 409
+++ ++ER+L E E A R+ ++ ++S + + E R R +V +K+ E +
Sbjct: 1567 FNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNE 1626
Query: 410 AELEA----KMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFM--TSQLD 463
E++ +M + V K+ +K + + + +D+K + + + + L
Sbjct: 1627 MEIQLSHANRMAAEAQKQV---KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL 1683
Query: 464 ANNMEELKEVAKRLSRDQRFRE 485
+EEL+ V ++ R ++ E
Sbjct: 1684 QAELEELRAVVEQTERSRKLAE 1705
Score = 58.5 bits (140), Expect = 1e-08
Identities = 61/253 (24%), Positives = 108/253 (42%), Gaps = 40/253 (15%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVV 205
+ +KSL++ L K+ Q LD + ++L +E +ER N +L+AE ++ VV
Sbjct: 1642 QKQVKSLQS----LLKDTQIQLDDAVRANDDL---KENIAIVERRNNLLQAELEELRAVV 1694
Query: 206 QELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENE 265
++ T R K EQE E + L L +KKK +E +
Sbjct: 1695 EQ--------------TERSRKLAEQELIETSERVQLLHSQNTSLINQKKK----MESDL 1736
Query: 266 NHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREF 325
LQ+ ++ Q R EEK ++ + + + + +K+ ++ S LE ++
Sbjct: 1737 TQLQSEVEEAVQ---------ECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1787
Query: 326 YSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRN 385
+ LQ+ L E + LK K LE R+RE EG L + ++ V+
Sbjct: 1788 MEQTIKDLQHRLDE------AEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKG 1841
Query: 386 KEKEERMRADVSH 398
K ER ++++
Sbjct: 1842 MRKSERRIKELTY 1854
Score = 56.6 bits (135), Expect = 5e-08
Identities = 54/240 (22%), Positives = 109/240 (45%), Gaps = 28/240 (11%)
Query: 169 KLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKG 228
K E +E+ +E+ ++ + EA +++ EE + L E K +L+L
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQE----KNDLQLQ------ 892
Query: 229 VEQEKKELRHLTESLQQTLE---ELSIEKKKTLEMLE-ENENHLQTLANQSEQPPPSGGL 284
V+ E+ L E Q ++ +L + K+ E LE E E + + A + + L
Sbjct: 893 VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952
Query: 285 HSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEK 344
++ +E + ++ +EK E ++K E L+E + + +ALQ + Q+ +
Sbjct: 953 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL 1012
Query: 345 QQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVSHLKRFFE 404
Q E ++ + K ++ LE+++ + EG+L E+E+++R D+ KR E
Sbjct: 1013 QVEEDKVNSLSKSKVKLEQQVDDLEGSL--------------EQEKKVRMDLERAKRKLE 1058
Score = 42.7 bits (99), Expect = 8e-04
Identities = 33/185 (17%), Positives = 91/185 (49%), Gaps = 16/185 (8%)
Query: 151 SLEAQGLQLAKEKQEYLDKLMEETEELCLQREQR-EELERLNQVLEAEKQQFEEVVQELR 209
++ A+ L+ ++ +L+++ + E+ + R +E E++ L+ K+Q +++ +R
Sbjct: 1765 AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI--ALKGGKKQLQKLEARVR 1822
Query: 210 MEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQ 269
+ +++ E + A +KG+ + ++ ++ LT + E KK L L++ + LQ
Sbjct: 1823 ELEGELEAEQKRNAESVKGMRKSERRIKELTYQTE--------EDKKNLLRLQDLVDKLQ 1874
Query: 270 ----TLANQSEQPPPSGGLH-SNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEERE 324
Q+E+ + S R+++ ++ + E +AE ++ + +SR + +++
Sbjct: 1875 LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQK 1934
Query: 325 FYSSQ 329
+ +
Sbjct: 1935 MHDEE 1939
Score = 40.4 bits (93), Expect = 0.004
Identities = 48/235 (20%), Positives = 103/235 (43%), Gaps = 26/235 (11%)
Query: 251 SIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMK 310
S E +K + ++E ++ +SE + +++EEKM LL+EK + +++
Sbjct: 844 SAETEKEMATMKEEFGRIKETLEKSE---------ARRKELEEKMVSLLQEKNDLQLQVQ 894
Query: 311 ENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEG 370
++ EE + Q ++N +Q L A+ ++ L+ E ++ +L + R+ E
Sbjct: 895 AEQDNLNDAEERCD------QLIKNKIQ-LEAKVKEMNERLEDEEEMNAELTAKKRKLED 947
Query: 371 ALRSLEQGLNS-KVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKA 429
L++ ++ ++ + E+ A + +K EE E+ AK+ K H+
Sbjct: 948 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1007
Query: 430 ATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLD--ANNMEELKEVAKRLSRDQR 482
A ++ N + S+ + Q+D ++E+ K+V L R +R
Sbjct: 1008 ALDDLQV-------EEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1055
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 71.2 bits (173), Expect = 2e-12
Identities = 76/385 (19%), Positives = 174/385 (45%), Gaps = 32/385 (8%)
Query: 121 EFEQTQWL--EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELC 178
E E+ W E ++E + W+ E + E Q + ++ ++ +++ E+ E L
Sbjct: 352 EQEEKMWEQEEKMREQEEKMWRQ----EERLWEQEKQMREQEQKMRDQEERMWEQDERLR 407
Query: 179 LQREQREELERLNQVLE--AEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKEL 236
+ E+ E E++ + +E E+++ +E ++ R ++E+++ E + R K + +E++ +
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER-EKKMREEEETM 466
Query: 237 RHLTESLQQTLEEL--SIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEK 294
R E +Q+ E + EK+ + L E + L EQ +R EE
Sbjct: 467 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 526
Query: 295 MQQLLEEKLLAEKRMKENE----ERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERE 350
Q E+K+ +++M+E E E+ + ++ + Q + ++ QE + E +
Sbjct: 527 WGQ--EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK 584
Query: 351 LKAEVKVRMDLERRLREAEGALRSLEQGL-NSKVRNKEKEERMRADVSHL----KRFFEE 405
++ E ++R + E+++RE E +R E+ + + + +E+EE+M + ++ +E+
Sbjct: 585 MREEERMR-EREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ 643
Query: 406 CIRNAELEAKM-----PVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTS 460
+ E E KM K ++ H+ + K + + W K +
Sbjct: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKM----QEQEEKIWEQEKMEKKTQEQ 699
Query: 461 QLDANNMEELKEVAKRLSRDQRFRE 485
+ + E+++E R+++ RE
Sbjct: 700 EKKTWDQEKMREEESMREREKKMRE 724
Score = 70.1 bits (170), Expect = 5e-12
Identities = 69/280 (24%), Positives = 133/280 (47%), Gaps = 35/280 (12%)
Query: 140 KNAQLGEAM-IKSLEAQGLQL----AKEKQEYLDKLMEETEELCLQRE---QREELERLN 191
KNA+L E + + E +QL K K E L+ + + LQ E Q EEL
Sbjct: 226 KNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE 285
Query: 192 QVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELS 251
+ + ++++ + LR ++ +++ + E R K + +++KELR + L+
Sbjct: 286 KKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR------- 338
Query: 252 IEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKE 311
E+K+ E E+ + + + Q E+ +R+ EEKM + E EK+M+E
Sbjct: 339 -EQKELREQEEQMQEQEEKMWEQEEK----------MREQEEKMWRQEERLWEQEKQMRE 387
Query: 312 NEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGA 371
E++ R +EER + Q + L+ E++ E+E E +M E++++E E
Sbjct: 388 QEQKMRD-QEERMW--EQDERLREK------EERMREQEKMWEQVEKMREEKKMQEQEKK 438
Query: 372 LRSLEQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAE 411
R E+ + + R +E+E++MR + ++ E+ + E
Sbjct: 439 TRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE 478
Score = 69.7 bits (169), Expect = 6e-12
Identities = 71/276 (25%), Positives = 129/276 (46%), Gaps = 20/276 (7%)
Query: 118 AESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEEL 177
AESE + Q L + + K+ L + +L+ + + +E +E K+ ++ E++
Sbjct: 237 AESEKSEIQ-LNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
Query: 178 CLQREQREELERLNQVLEAEKQQFEEVVQELRM-EQEQIKRELELTARCLKGVEQEKKEL 236
Q E+ E E ++ E E++ + QE R+ EQE+ RE E R E+KEL
Sbjct: 296 WRQEERLREQE--GKMREQEEKMWR---QEKRLREQEKELREQEKELR-------EQKEL 343
Query: 237 RHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQ 296
R E +Q+ E++ +++K E E+ + L Q +Q +R EE+M
Sbjct: 344 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ---EQKMRDQEERMW 400
Query: 297 QLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVK 356
+ E E+RM+E E+ +E+ RE Q Q + QE EK Q E ++ K
Sbjct: 401 EQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE---EKMQEEERIREREK 457
Query: 357 VRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERM 392
+ E +RE E ++ E+ + + + +++R+
Sbjct: 458 KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493
Score = 67.8 bits (164), Expect = 2e-11
Identities = 60/238 (25%), Positives = 112/238 (47%), Gaps = 21/238 (8%)
Query: 161 KEKQEYLDKLMEETEELCLQREQR----EELERLNQVLEAEKQQFEEVVQELRMEQEQIK 216
K+ Y+++L +E + L L+ + EEL++ N L+ + E E+++ +++K
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELK 252
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
R+LE L V+ L E + + EEL ++KK + E+ + L Q
Sbjct: 253 RKLERAKFLLPQVQTNT-----LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQ-- 305
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
+R+ EEKM + + EK ++E E+ R +E RE Q Q +
Sbjct: 306 --------EGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELRE-QEEQMQEQEEK 356
Query: 337 LQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGL-NSKVRNKEKEERMR 393
+ E + ++ E ++ + + + E+++RE E +R E+ + R +EKEERMR
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 414
Score = 66.2 bits (160), Expect = 6e-11
Identities = 71/291 (24%), Positives = 130/291 (44%), Gaps = 30/291 (10%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELC 178
E E + + E + E + W+ +L E K E + +Q E +K+ E+ E++
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ------EQEEKIWEQEEKIR 521
Query: 179 LQRE---QREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKE 235
Q E Q +++ R ++ E E Q +E+ + EQ+ +E + K EQEKK
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK---KTQEQEKK- 577
Query: 236 LRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKM 295
T ++ + E +++ +M EE E + EQ + + EEKM
Sbjct: 578 ----TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKM 633
Query: 296 QQLLEEKLLAEKRMKENEER----SRALEEEREFYSSQSQALQNSLQEL--------TAE 343
Q+ E+ E++M E EE+ R E++ + + + Q +QE E
Sbjct: 634 QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKME 693
Query: 344 KQQAERELKAEVKVRMDLERRLREAEGALRSLEQGL-NSKVRNKEKEERMR 393
K+ E+E K + +M E +RE E +R E+ + + + +E+EE+M+
Sbjct: 694 KKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQ 744
Score = 65.5 bits (158), Expect = 1e-10
Identities = 61/292 (20%), Positives = 135/292 (46%), Gaps = 30/292 (10%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQ-LGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEEL 177
E E + + E +QE + W+ + + E K E + +E++ + + + E +E
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666
Query: 178 CLQREQREELERLNQ----VLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEK 233
+ E+ +E E++ + + E EK + + QE + ++ RE E K + +E+
Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
Query: 234 KELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGL--HSNLR-- 289
+ +R E +Q+ E++ ++++ E E+ + + Q P L H ++
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
Query: 290 ----QIEEKMQQLLEEKLLAEKRMKENEERSRALEE----EREFYSSQSQALQNSLQELT 341
+ EEKM+ E+ E++M+ EE+ R EE + E Q + + +++
Sbjct: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
Query: 342 AEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMR 393
++++ E +++ + E ++RE E +R E+ + +E+EE+MR
Sbjct: 847 GQEEKMEEKMQGQ-------EEKMREQEEKMRGQEE------KMREQEEKMR 885
Score = 63.9 bits (154), Expect = 3e-10
Identities = 65/278 (23%), Positives = 139/278 (50%), Gaps = 31/278 (11%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAK-----EKQEYLDKLMEETEELCLQR-- 181
E +QE + W+ E I+ E Q K + +E D++ E+ E++ Q
Sbjct: 504 EKMQEQEEKIWEQ----EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559
Query: 182 --EQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHL 239
+Q E +E+ Q E EK+ ++ QE +M +E+ RE E K + +E++ +R
Sbjct: 560 MWDQEERMEKKTQ--EQEKKTWD---QEEKMREEERMRERE------KKMREEEEMMREQ 608
Query: 240 TESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLL 299
E +Q+ E++ +++K E E+ + + + Q E+ +++ E+ ++L
Sbjct: 609 EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668
Query: 300 E-EKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQ---QAERELKAEV 355
E EK+ +++M+E EE + E+E+ +Q Q + QE E++ + E++++ E
Sbjct: 669 EHEKMQEQEKMQEQEE--KIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
Query: 356 KVRMDLERRLREAEGALRSLEQGL-NSKVRNKEKEERM 392
++ + E +++E E ++ E+ + + + E+EE+M
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
Score = 60.8 bits (146), Expect = 3e-09
Identities = 56/265 (21%), Positives = 122/265 (46%), Gaps = 11/265 (4%)
Query: 129 EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLD--KLMEETEELCLQREQREE 186
E+ ++ K+ + ++ + E +G +E++ + +L E+ +EL REQ +E
Sbjct: 280 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKEL---REQEKE 336
Query: 187 LERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTA-RCLKGVEQEKKELRHLTESLQQ 245
L ++ E E+Q E+ +E EQE+ RE E R + + +++K++R + ++
Sbjct: 337 LREQKELREQEEQMQEQ--EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD 394
Query: 246 TLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLA 305
EE E+ + L EE + + Q E+ + ++ ++ +++ EE+ +
Sbjct: 395 Q-EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
Query: 306 EKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRL 365
E+ K EE E+E + + + +E ++ ++E E + + E ++
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
Query: 366 REAEGALRSLEQ--GLNSKVRNKEK 388
E E +R E+ G K+ +EK
Sbjct: 514 WEQEEKIRDQEEMWGQEKKMWRQEK 538
Score = 60.8 bits (146), Expect = 3e-09
Identities = 65/276 (23%), Positives = 126/276 (45%), Gaps = 42/276 (15%)
Query: 132 QESGKVTW-------KNAQLGEAMIKSLEAQGLQLAKEK--QEYLDKLMEETEELCLQRE 182
QE K TW + ++ E K E + + +E+ QE +K+ E+ E++ Q E
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Query: 183 QREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTES 242
+ +E E ++ E E++ +E+ +E EQ+++ + E K EQEK
Sbjct: 632 KMQEQEE--KMWEQEEKMWEQ--EEKMWEQQRLPEQKEKLWEHEKMQEQEK--------- 678
Query: 243 LQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEK 302
Q EE E++K + +E E E+ ++R+ E+KM++ EE+
Sbjct: 679 -MQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE--------ESMREREKKMRE--EEE 727
Query: 303 LLAEKRMKENEERSRALEEEREFYSSQSQALQNS-----LQELTAEKQQA-ERELKAEVK 356
++ E+ K E+ + E+E E + + + + Q L +K++ E E E +
Sbjct: 728 MMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 787
Query: 357 VRMDLERRLREAEGALRSLEQ---GLNSKVRNKEKE 389
+ E ++R+ E +R E+ G K+R +E++
Sbjct: 788 KIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK 823
Score = 60.1 bits (144), Expect = 5e-09
Identities = 57/267 (21%), Positives = 123/267 (46%), Gaps = 22/267 (8%)
Query: 121 EFEQTQWL--EMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELC 178
E E+ W E + E + W+ +L E K E + +Q ++ QE +K+ E+ E
Sbjct: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ--EKM 692
Query: 179 LQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRH 238
++ Q +E + +Q E++ E +++R E+E ++ + E + ++++++E+
Sbjct: 693 EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWE 752
Query: 239 LTESLQQTLEEL-----SIEKKKTL---EMLEENENHLQTLANQSEQPPPSGGLHSNLRQ 290
E + + E++ E+K+ L E ++E E + +Q G +R
Sbjct: 753 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRG 812
Query: 291 IEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERE 350
EEKM+ E+ E++M EE+ EE+ Q + ++ +Q + ++ E +
Sbjct: 813 QEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEK---MWGQEEKMEEKMQGQEEKMREQEEK 869
Query: 351 LKAEVKVRMDLERRLREAEGALRSLEQ 377
++ + E ++RE E +R E+
Sbjct: 870 MRGQ-------EEKMREQEEKMRGQEE 889
Score = 59.7 bits (143), Expect = 6e-09
Identities = 57/248 (22%), Positives = 118/248 (47%), Gaps = 11/248 (4%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVV 205
E I+ E + + + +E K+ E+ E++ Q ++ E E+ ++ E EK+ E+
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEK--ELREQEKELREQ-- 340
Query: 206 QELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENE 265
+ELR ++EQ++ + E K EQE+K +R E + + E L ++K+ E ++
Sbjct: 341 KELREQEEQMQEQEE------KMWEQEEK-MREQEEKMWRQEERLWEQEKQMREQEQKMR 393
Query: 266 NHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREF 325
+ + + Q E+ ++ E+++++ EEK + E+ K ++ + EEER
Sbjct: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
Query: 326 YSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRN 385
+ + EK Q + E E + + ++RL E + L E+ + +
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
Query: 386 KEKEERMR 393
E+EE++R
Sbjct: 514 WEQEEKIR 521
Score = 58.5 bits (140), Expect = 1e-08
Identities = 67/341 (19%), Positives = 149/341 (43%), Gaps = 51/341 (14%)
Query: 121 EFEQTQWLEM-LQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCL 179
E E+ +W + L E + W+ ++ E K E + +E+ +K M E++
Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 541
Query: 180 QR----EQREELERLNQVLEAEKQQFEEVVQELRM---EQEQIKRELELTARCLKGVEQE 232
Q EQ E++ Q + ++++ E+ QE +QE+ RE E K + +E
Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601
Query: 233 KKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIE 292
++ +R E +Q+ E++ +++K E E+ + + + Q E+ +++
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 293 EKMQQLLE-EKLLAEKRMKENEER--------SRALEEEREFYSSQSQALQNSLQELTAE 343
E+ ++L E EK+ +++M+E EE+ + E+E++ + + + S++E +
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721
Query: 344 KQQAERELKAEVKVRMDLERRLREAEGALRSLEQGL----------------------NS 381
++ E ++ + + + E +++E E + E+ + +
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781
Query: 382 KVRNKEK-----------EERMRADVSHLKRFFEECIRNAE 411
K++ +EK EE+MR + R EE +R E
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKM-RGQEEKMRGQE 821
Score = 57.8 bits (138), Expect = 2e-08
Identities = 69/295 (23%), Positives = 138/295 (46%), Gaps = 32/295 (10%)
Query: 130 MLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQ-REELE 188
M ++ K+ + + E K + Q L KEK +K+ E+ E++ Q E+ R++ E
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 525
Query: 189 RLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLE 248
Q + +Q+ ++ EQE+ R+ E K +QE++ + E ++T +
Sbjct: 526 MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ-----KMWDQEERMEKKTQEQEKKTWD 580
Query: 249 ELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKR 308
+ EK + E + E E ++ + E+ +R+ EEKMQ+ E+ E++
Sbjct: 581 QE--EKMREEERMREREKKMR----EEEEM---------MREQEEKMQEQEEKMQEQEEK 625
Query: 309 MKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREA 368
M E EE+ ++E+ E Q + + +++ +++ E++ K +M + +++E
Sbjct: 626 MWEQEEK---MQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ 682
Query: 369 EGALRSLEQGLNSKVRNKEK----EERMRADVS---HLKRFFEECIRNAELEAKM 416
E + E+ + K + +EK +E+MR + S K+ EE E E KM
Sbjct: 683 EEKIWEQEK-MEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKM 736
Score = 51.6 bits (122), Expect = 2e-06
Identities = 51/217 (23%), Positives = 103/217 (47%), Gaps = 23/217 (10%)
Query: 119 ESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELC 178
E +EQ + + QE K TW K E + ++ ++K +++M E EE
Sbjct: 684 EKIWEQEKMEKKTQEQEKKTWDQE-------KMREEESMREREKKMREEEEMMREQEEKM 736
Query: 179 LQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEK----- 233
++E++ + E+ ++ E E++ +E+ +E EQ+++ + E K EQEK
Sbjct: 737 QEQEEKMQ-EQEEEMWEQEEKMWEQ--EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE 793
Query: 234 KELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE----QPPPSGG----LH 285
+++R E ++ E++ +++K E+ + + Q E Q G +
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKME 853
Query: 286 SNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEE 322
++ EEKM++ E+ E++M+E EE+ R EE+
Sbjct: 854 EKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Score = 48.5 bits (114), Expect = 1e-05
Identities = 54/281 (19%), Positives = 111/281 (39%), Gaps = 21/281 (7%)
Query: 224 RCLKGVEQEKKELRHLTESLQQTLEELSIEKKK---TLEMLEENENHLQTLANQSEQPPP 280
R L V K+ E L + + LS+E + T E L++ LQ +E
Sbjct: 183 RALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKS 242
Query: 281 SGGLHSNLRQIEEKMQQ------------LLEEKLLAEKRMKENEERSRALEEEREFYSS 328
+ N+++++ K+++ L EE E+ ++E E++ R EE+
Sbjct: 243 E--IQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE 300
Query: 329 QSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEK 388
+ + + ++E + + E+ L+ + K + E+ LRE + EQ + + E+
Sbjct: 301 RLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQ 360
Query: 389 EERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSW 448
EE+MR + R E + + M++ R++ R W
Sbjct: 361 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 420
Query: 449 ND---MKPSQSFMTSQLDANNMEELKEVAKRL-SRDQRFRE 485
M+ + + + EE + +R+ R+++ RE
Sbjct: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE 461
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 71.2 bits (173), Expect = 2e-12
Identities = 90/375 (24%), Positives = 173/375 (46%), Gaps = 40/375 (10%)
Query: 128 LEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREEL 187
LE ++ G K+A E+ ++ + + ++K ++ + EE +EQ+EE
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 188 ERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTL 247
E EA K E+ V L+ + K++++ ++ +E+ KK+L E+L Q L
Sbjct: 1356 E------EARK-NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL 1408
Query: 248 EELSIEKKKTLEMLEENENHL-QTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAE 306
E EK + LE+ +N L Q L + + + SNL + ++K QLL E+
Sbjct: 1409 E----EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS 1464
Query: 307 KRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAER---ELKAEVKVRM---- 359
R E +R+ A E+E +++ +L +L+E K++ ER +L+A+++ M
Sbjct: 1465 ARYAEERDRAEAEAREKE---TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 360 DLERRLREAEGALRSLEQGLNSKVRNKEKEE-----------RMRADVSHLKRFFEECI- 407
D+ + + E E + R+LEQ + E+ E R+ ++ +K FE +
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 408 -RNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANN 466
R+ + E K +++K + ++ R R + S M+ + +Q++A N
Sbjct: 1582 TRDEQNEEKKRLLIKQV----RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN 1637
Query: 467 MEELKEVAKRLSRDQ 481
+ EV K+L + Q
Sbjct: 1638 -KARDEVIKQLRKLQ 1651
Score = 68.2 bits (165), Expect = 2e-11
Identities = 58/228 (25%), Positives = 113/228 (49%), Gaps = 24/228 (10%)
Query: 157 LQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIK 216
LQ+ ++++E L + EEL +E++ ++E + +E + QQ +++E + EQ++
Sbjct: 845 LQVTRQEEE----LQAKDEELLKVKEKQTKVEGELEEMERKHQQ---LLEEKNILAEQLQ 897
Query: 217 RELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE 276
E EL A E +E+R + +Q LEE+ + + +E EE LQ + +
Sbjct: 898 AETELFA--------EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQN--EKKK 947
Query: 277 QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
L L + E Q+L EK+ AE ++K+ EE LE++ + + + +++
Sbjct: 948 MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Query: 337 LQELTAEKQQAERELKAEVKVR-------MDLERRLREAEGALRSLEQ 377
+ E +++ + E + K K+R DLE RL++ E + LE+
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055
Score = 67.0 bits (162), Expect = 4e-11
Identities = 90/398 (22%), Positives = 169/398 (42%), Gaps = 76/398 (19%)
Query: 132 QESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLN 191
+E KV K ++ E ++ +E + QL +EK ++L ETE E E +
Sbjct: 859 EELLKVKEKQTKV-EGELEEMERKHQQLLEEKNILAEQLQAETELFA-------EAEEMR 910
Query: 192 QVLEAEKQQFEEVVQEL--RMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEE 249
L A+KQ+ EE++ +L R+E+E+ + ++ ++ EKK+++ + L++ L+E
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQI---------LQNEKKKMQAHIQDLEEQLDE 961
Query: 250 -------LSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGL--------HSNLRQIEEK 294
L +EK +++ E + L +Q+ + L S L + EEK
Sbjct: 962 EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 295 MQQL-------------LEEKL-LAEKRMKENEERSRALEEEREFYSSQSQALQNSLQEL 340
+ L LEE+L EK +E E+ R L+ E Q LQ + EL
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081
Query: 341 TAEKQQAERELKA-------EVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMR 393
+ + E EL+ E + + + +RE + + L++ S+ ++ K E+ +
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141
Query: 394 ADVSH----LKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWN 449
D+S LK E+ + + ++ + V K K+ +
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK------KALEEETKNHEAQIQ 1195
Query: 450 DMKPSQSFMTSQLDANNMEELKEVAKRLSRDQRFRESI 487
DM+ Q A +EEL E +L + +RF+ ++
Sbjct: 1196 DMR--------QRHATALEELSE---QLEQAKRFKANL 1222
Score = 65.1 bits (157), Expect = 1e-10
Identities = 66/286 (23%), Positives = 131/286 (45%), Gaps = 32/286 (11%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQ---LGEAMIKSLEAQGLQLAKEKQEYLDKLME 172
+A+ E +Q ++ ++L E ++ + A+ EA + E + L LA+ +E L
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL----- 1496
Query: 173 ETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQE 232
E +EE ER N+ L A+ +++L ++ + + + + + +EQ+
Sbjct: 1497 ---------EAKEEFERQNKQLRAD-------MEDLMSSKDDVGKNVHELEKSKRALEQQ 1540
Query: 233 KKELRHLTESLQQTLEELSIEKKKTLE-----MLEENENHLQTLANQSEQPPPSGGLHSN 287
+E+R E L+ L+ + K LE M + E LQT Q+E+ L
Sbjct: 1541 VEEMRTQLEELEDELQATE-DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL--LIKQ 1597
Query: 288 LRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQA 347
+R++E +++ +++ LA K+ E + LE + E + + L++L A+ +
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657
Query: 348 ERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMR 393
+REL+ R ++ + +E+E L+SLE + ER R
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703
Score = 62.8 bits (151), Expect = 7e-10
Identities = 61/273 (22%), Positives = 115/273 (42%), Gaps = 10/273 (3%)
Query: 146 EAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVV 205
E +K LEAQ K + E + +L + ++ + + EE + A+ ++ E+ +
Sbjct: 1623 EIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682
Query: 206 QELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENE 265
+ L E Q++ EL + R + EQE+ EL + L EK++ + + E
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 266 NHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEER-- 323
L+ QS + Q++ +L E+ A+K ++ R +E +
Sbjct: 1743 EELE--EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAK 1800
Query: 324 --EFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNS 381
E + + ++ L A+ Q E +L+ E K R + +R E L+ + +
Sbjct: 1801 LQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVED 1860
Query: 382 KVRN----KEKEERMRADVSHLKRFFEECIRNA 410
+ R+ KE+ E+ A + LKR EE A
Sbjct: 1861 ERRHADQYKEQMEKANARMKQLKRQLEEAEEEA 1893
Score = 60.5 bits (145), Expect = 4e-09
Identities = 74/340 (21%), Positives = 141/340 (41%), Gaps = 45/340 (13%)
Query: 94 KEEPSMPYAMKISHQDFHGNILLAAESEFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLE 153
KEE + + H N L E Q Q E LQE + + E + L
Sbjct: 1088 KEEELQGALARGDDETLHKNNALKVVREL-QAQIAE-LQEDFESEKASRNKAEKQKRDLS 1145
Query: 154 AQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQ- 212
+ L E ++ LD + E L+ ++ +E+ L + LE E + E +Q++R
Sbjct: 1146 EELEALKTELEDTLDTTAAQQE---LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202
Query: 213 ---EQIKRELELTARCL-------KGVEQEKKELRHLTESLQQTLEELSIEKKK------ 256
E++ +LE R +G+E + KEL + LQQ E ++KK
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262
Query: 257 ------------TLEMLE-----ENE-NHLQTLANQSEQ-----PPPSGGLHSNLRQIEE 293
+E+ E +NE +++ TL ++E+ + L S L+ +E
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322
Query: 294 KMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKA 353
+Q+ +KL R+++ EE +L+E++E + L+ + L ++ ++++
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 354 EVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMR 393
++ LE ++ +L Q L K +K E+ +
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTK 1422
Score = 60.1 bits (144), Expect = 5e-09
Identities = 67/277 (24%), Positives = 132/277 (47%), Gaps = 51/277 (18%)
Query: 148 MIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQE 207
+++ E +G++ AK+ L+ +++T+EL LQ E R++L +++ + E+++ +QE
Sbjct: 1295 LLEEAEKKGIKFAKDAAS-LESQLQDTQEL-LQEETRQKLNLSSRIRQLEEEK--NSLQE 1350
Query: 208 LRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENH 267
+ E+E+ ++ LE K++ L L T +++ + T+E LEE +
Sbjct: 1351 QQEEEEEARKNLE-------------KQVLALQSQLADTKKKVD-DDLGTIESLEEAKKK 1396
Query: 268 LQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRA--------L 319
L A E + Q LEEK LA ++++ + R + L
Sbjct: 1397 LLKDA--------------------EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436
Query: 320 EEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGA--LRSLEQ 377
+ +R+ S+ + + Q L EK + R AE + R + E R +E + R+LE+
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARY--AEERDRAEAEAREKETKALSLARALEE 1494
Query: 378 GLNSKVRNKEKEERMRADVSHLKRFFEECIRNA-ELE 413
L +K + + +++RAD+ L ++ +N ELE
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531
Score = 59.7 bits (143), Expect = 6e-09
Identities = 80/393 (20%), Positives = 174/393 (44%), Gaps = 48/393 (12%)
Query: 135 GKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYL-------DKLMEETEELCLQREQREEL 187
G+ T Q+ E + E + LQLAK+++E D+ + + L + RE + ++
Sbjct: 1062 GETTDLQDQIAELQAQIDELK-LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 188 ERLNQVLEAEK---QQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQ 244
L + E+EK + E+ ++L E E +K ELE T ++ + + L+
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 245 QTLEELSIEKKKTLE-MLEENENHLQTLANQSEQPPP-SGGLHSNLRQIEEKMQQLL-EE 301
+ LEE + + ++ M + + L+ L+ Q EQ L N + +E ++L E
Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 302 KLLAEKRMKENEERSRALEEEREFYSSQSQA-------------LQNSLQELTAEKQQAE 348
K+L + + + +R + + +E ++ S+ LQN L ++ ++AE
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300
Query: 349 RELKAEVKVRMDLERRLREAEGAL--------------RSLEQGLNSKVRNKEKEERMRA 394
++ K LE +L++ + L R LE+ NS +E+EE R
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360
Query: 395 DVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRR---SSTSWNDM 451
++ K+ + A+ + K+ + + +A + +K +R + +++ +
Sbjct: 1361 NLE--KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 452 KPSQSFMTSQLD--ANNMEELKEVAKRLSRDQR 482
+ +++ + +LD +++ ++VA L + Q+
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQK 1451
Score = 58.5 bits (140), Expect = 1e-08
Identities = 63/284 (22%), Positives = 121/284 (42%), Gaps = 23/284 (8%)
Query: 128 LEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKE-------KQEYLDKLMEETEELCLQ 180
LE + S + ++ E +KSLEA+ LQL +E ++ + E +E+
Sbjct: 1661 LEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720
Query: 181 REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLT 240
+ L + LEA Q EE ++E + E + T + + E R
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780
Query: 241 ESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLE 300
+ ++L + K+ L+E E A +S+ L + + Q+EE+++Q +
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEG-----AVKSKFKATISALEAKIGQLEEQLEQEAK 1835
Query: 301 EKLLAEKRMKENEERSRA----LEEER---EFYSSQSQALQNSLQELTAEKQQAERELKA 353
E+ A K ++ E++ + +E+ER + Y Q + +++L + ++AE E
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR 1895
Query: 354 EVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADVS 397
R L+R L +A A +GL+ +V + R +S
Sbjct: 1896 ANASRRKLQRELDDATEA----NEGLSREVSTLKNRLRRGGPIS 1935
Score = 35.8 bits (81), Expect = 0.094
Identities = 36/203 (17%), Positives = 89/203 (43%), Gaps = 21/203 (10%)
Query: 306 EKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQ------QAERELKAEV-KVR 358
E+ ++ +E ++E++ + + ++ Q+L EK QAE EL AE ++R
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 359 MDLERRLREAEGALRSLEQGLNSKVRNKE----KEERMRADVSHLKRFFEE--------C 406
L + +E E L LE + + + ++++M+A + L+ +E
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 407 IRNAELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMTSQLDANN 466
+ EAK+ + + + + ++ IK + R + + + + + N
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 467 MEE--LKEVAKRLSRDQRFRESI 487
+E + ++ +RL ++++ R+ +
Sbjct: 1031 KQEVMISDLEERLKKEEKTRQEL 1053
>gi|122937396 coiled-coil domain containing 150 [Homo sapiens]
Length = 1101
Score = 71.2 bits (173), Expect = 2e-12
Identities = 73/279 (26%), Positives = 129/279 (46%), Gaps = 23/279 (8%)
Query: 151 SLEAQGLQLAKEKQEYLDKLMEETEELCLQREQREEL-ERLNQVLEAEKQQFEEVVQELR 209
SLE Q LQ Q LD + E+ E L+R+ E +R+ + + E + E ++ LR
Sbjct: 774 SLE-QALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALR 832
Query: 210 MEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQ 269
+Q + E E T K ++E EL+ + E+S ++ + L E E L+
Sbjct: 833 ---KQFQTERETTK---KVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILE 886
Query: 270 T----LANQSEQPPPSGGLHSNLRQIEEKMQQLLEE----KLLAEKRMKENEERSRALEE 321
+ + NQ Q +N Q E+M+Q+ +E +L+ ++ K+N E+S +++
Sbjct: 887 SNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQR 946
Query: 322 ---EREFYSSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSL--- 375
E + Q L S + + +Q E L+AE K+R +LE R +E E +R L
Sbjct: 947 FVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKC 1006
Query: 376 -EQGLNSKVRNKEKEERMRADVSHLKRFFEECIRNAELE 413
E N+ + E++ A++ R+F+ +LE
Sbjct: 1007 KEATENTLKEASVESEQITANLEEAHRWFKHRFDGLQLE 1045
Score = 52.8 bits (125), Expect = 7e-07
Identities = 61/257 (23%), Positives = 120/257 (46%), Gaps = 20/257 (7%)
Query: 152 LEAQGLQLAKEKQEYLDKLMEETEELCLQREQREE-LERLNQVLEAEKQQFEEVVQEL-R 209
L+A L E + + K + + +Q+E E + RL LEA Q+ + +++E R
Sbjct: 417 LQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKER 476
Query: 210 MEQEQIKRELELT-ARC--LKGVEQEKKELRHLTESLQQTLEELS---IEKKKTLEMLEE 263
++E K E E+ RC K + + K ++ LT +L QTLEE + ++ +LE+ +
Sbjct: 477 FQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNL-QTLEEENKHLADQMASLELQQV 535
Query: 264 NENHLQTLANQSEQPPPS--------GGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEER 315
++ + E+ S G L ++Q+EE++Q + L + K N+
Sbjct: 536 TSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYL 595
Query: 316 SRALEEEREFYSSQSQALQNS---LQELTAEKQQAERELKAEVKVRMDLERRLREAEGAL 372
+ S++ LQ + L+E+ + ++++ EL VK R + ++ + L
Sbjct: 596 QTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDL 655
Query: 373 RSLEQGLNSKVRNKEKE 389
++E N KV N +++
Sbjct: 656 EAVEDRENKKVGNFQRQ 672
Score = 42.0 bits (97), Expect = 0.001
Identities = 71/349 (20%), Positives = 139/349 (39%), Gaps = 61/349 (17%)
Query: 123 EQTQWLEMLQESGKVTWKNAQLGEAMIKS------LEAQGLQLAKEKQEYLDKLMEETEE 176
++ Q L + T KNA + E +K+ L+ Q L+ +++YL + +E++
Sbjct: 176 DEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSAS 235
Query: 177 LCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKEL 236
L + ++ + +E E++Q + Q ++ I+ EL A+ EQ+KKE
Sbjct: 236 AMLLK-----IQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQ-----EQKKKEE 285
Query: 237 RHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQ 296
+ S Q +L+ +++EEN+N + + E+ +L + EK Q
Sbjct: 286 LEIATS--QLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQ 343
Query: 297 QLLEEK----------------------------LLAEKRMKEN--EERSRALEEEREFY 326
L ++ L E++M +E++ L+
Sbjct: 344 VLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASI 403
Query: 327 SSQSQALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRS--------LEQG 378
+++ Q +QN +L A E ++ D E+R + L S LE
Sbjct: 404 TNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEAS 463
Query: 379 LNSKVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIH 427
+ K E++ER + +V+ ++ + N E E + KN V I+
Sbjct: 464 MQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKE-----LAKNKVDIN 507
Score = 29.3 bits (64), Expect = 8.8
Identities = 28/152 (18%), Positives = 66/152 (43%), Gaps = 4/152 (2%)
Query: 236 LRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKM 295
L L +SL+ + L EK + ++ L + Q E LH + + +++
Sbjct: 107 LESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAI--QEEHSKDLKLLHLEVMNLRQQL 164
Query: 296 QQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEV 355
+ + EE+ A+ ++ + + ++ + + L+ + +++ + Q+ R+L E
Sbjct: 165 RAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEK 224
Query: 356 KVRMDLERRLREAEGALRSLEQGLNSKVRNKE 387
+R LE+ + L+ E G +V K+
Sbjct: 225 YLRESLEK--SASAMLLKIQEMGSTVEVERKQ 254
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 70.9 bits (172), Expect = 3e-12
Identities = 83/336 (24%), Positives = 152/336 (45%), Gaps = 41/336 (12%)
Query: 122 FEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYL-------DKLMEET 174
F +TQ L+E G ++++ + ++ L+A G LAK +E +K++E
Sbjct: 754 FVKTQLYGFLKEMGSEVSEDSEEKD-VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELE 812
Query: 175 EEL-CLQRE---QREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVE 230
+E+ CLQ E Q EEL+ L + E EK + ++E++ E+E ++ +L +
Sbjct: 813 KEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTR 872
Query: 231 QEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSE-------------- 276
E + L E + QT + I +K ++E+EN L+ L Q E
Sbjct: 873 LENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHEN-LKPLLEQKELRDRRAELILLKDS 931
Query: 277 ---QPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSS--QSQ 331
P S+++++EEK++ L EK EK K N+ + A++ ++E SS ++Q
Sbjct: 932 LAKSPSVKNDPLSSVKELEEKIENL--EKECKEKEEKINKIKLVAVKAKKELDSSRKETQ 989
Query: 332 ALQNSLQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEER 391
++ L+ L +EK Q ++ ++ + L E E + EQ K R E R
Sbjct: 990 TVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYE---KQSEQLDVEKERANNFEHR 1046
Query: 392 MRADVSHLKRFFEEC----IRNAELEAKMPVIMKNS 423
+ L+ +C N +L A++ + N+
Sbjct: 1047 IEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNA 1082
Score = 60.1 bits (144), Expect = 5e-09
Identities = 69/351 (19%), Positives = 160/351 (45%), Gaps = 34/351 (9%)
Query: 157 LQLAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEA---EKQQFEEVVQELRMEQE 213
+Q AK + L+K +EE + + ++ L + L+A EK + E+ L+ E
Sbjct: 41 IQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENI 100
Query: 214 QIKRELELTARCL----KGVEQEK----KELRHLTESLQQTLEELSIEKKKTLEMLEENE 265
++K+E+E + + K +EQ KE+ +L L + S +K + LEE
Sbjct: 101 KMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAM 160
Query: 266 NHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQL---LEEKLLAEKRMKE--NEERSRALE 320
N T SEQ N+++++E+++++ EE++L ++ + +E+ +
Sbjct: 161 N---TQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 217
Query: 321 EEREFYSSQSQALQ---NSLQELTAEKQQAERELKAEVKVRMDLERRLREAE-GALRSLE 376
+ + + SQ Q NSLQE + + +E E+ +++ + EAE L L+
Sbjct: 218 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELK 277
Query: 377 QGLNSKVRNKEK--EERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSVYIHKAATRRI 434
+ L + EK +++ ++ +L++ ++ ++ ++++ + ++ + ++
Sbjct: 278 ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQI---CSILLQENTFVEQVVNEKV 334
Query: 435 KSCRFHRRRSSTSWNDMKPSQSFMTSQLDANNMEELKEVAKRLSRDQRFRE 485
K + + + +K ++M NN++ E+ + +D+ F E
Sbjct: 335 KHLEDTLKELESQHSILKDEVTYM------NNLKLKLEMDAQHIKDEFFHE 379
Score = 59.7 bits (143), Expect = 6e-09
Identities = 79/328 (24%), Positives = 149/328 (45%), Gaps = 56/328 (17%)
Query: 121 EFEQTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEEL--- 177
E E T ++ LQE V + + M+K LE + L +EK ++++KL EE+
Sbjct: 556 ELENT--IKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNF 613
Query: 178 --CLQREQR---------EELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCL 226
+RE+R E+ + N LE + + ++E E++Q ++LE +
Sbjct: 614 HKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQM 673
Query: 227 KGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHS 286
K + ++K+ L +SL + +LS EKK+ L+ +Q E L
Sbjct: 674 KVLSEDKEVLSAEVKSLYEENNKLSSEKKQL-------SRDLEVFLSQKEDVI----LKE 722
Query: 287 NLRQIEEKMQQLLEE-----KLLAEKRMKE-----------NEERSRALEE-EREFYSSQ 329
++ Q+E+K+Q ++EE KLL +++++ E S E+ E + +
Sbjct: 723 HITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNV 782
Query: 330 SQALQNSLQELTAEK-----QQAERELKAEVKVRMDLER---RLREAEGALRSLEQG--- 378
QA+ SL ++ EK Q+ E+ L+ E +++ E + E + LR EQ
Sbjct: 783 LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL 842
Query: 379 LNSKVRNKEKE-ERMRADVSHLKRFFEE 405
L ++ + E E +++D+ +K E+
Sbjct: 843 LRKELEEIQSEKEALQSDLLEMKNANEK 870
Score = 58.9 bits (141), Expect = 1e-08
Identities = 76/329 (23%), Positives = 142/329 (43%), Gaps = 46/329 (13%)
Query: 116 LAAESEFEQTQWLEMLQESGKVTWKNAQL---GEAMIKSLEAQGLQLAKEK-----QEYL 167
+ +E E Q+ LEM + K +N L E + ++ + KEK E L
Sbjct: 850 IQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENL 909
Query: 168 DKLMEETE------ELCLQREQR--------------EELERLNQVLEAEKQQFEEVVQE 207
L+E+ E EL L ++ +ELE + LE E ++ EE + +
Sbjct: 910 KPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINK 969
Query: 208 LRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENH 267
+++ + K+EL+ + + + V++E ESL+ ++LS + ++ E +N
Sbjct: 970 IKLVAVKAKKELDSSRKETQTVKEE-------LESLRSEKDQLSASMRDLIQGAESYKNL 1022
Query: 268 LQTLANQSEQPPPSGGLHSNL-RQIEEKMQQLLEEKLLAEKRMKENEE---RSRALEEER 323
L QSEQ +N +IE+ +QL L E +NE+ R L+
Sbjct: 1023 LLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNA 1082
Query: 324 EFYSSQSQALQNSL----QELTAEKQQAERELKAEVKVRMDLER---RLREAEGALRSLE 376
+ Q +Q + +EL AEK Q E+++K +LE +L++ + L+
Sbjct: 1083 KLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTM 1142
Query: 377 QGLNSKVRNKEKEERMRADVSHLKRFFEE 405
Q L ++ ++ M +++ +R +E
Sbjct: 1143 QELELVKKDAQQTTLMNMEIADYERLMKE 1171
Score = 54.3 bits (129), Expect = 3e-07
Identities = 81/369 (21%), Positives = 151/369 (40%), Gaps = 48/369 (13%)
Query: 157 LQLAKEKQEYLDKLMEETEEL--------CLQREQREELERLNQVLEAEKQQF----EEV 204
L+L + Q D+ E E+L + EQ +E+L L +QF E+
Sbjct: 363 LKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQH 422
Query: 205 VQELRMEQEQIKREL-ELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTL---EM 260
+E++ +EQ ++E+ EL L E+EK L + L++ E L EK++ + E
Sbjct: 423 NREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYES 482
Query: 261 LEENENHLQTLANQS-------------EQPPPSGGLHSNLRQIEEKMQQLLE------- 300
L E LQT +S +Q L LR + LLE
Sbjct: 483 LREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQG 542
Query: 301 --EKLLAEKRM-KENEERSRALEEEREFY-------SSQSQALQNSLQELTAEKQQAERE 350
EKLL+++ + E E + L+E+ Y + + L+ + LT EK +
Sbjct: 543 ENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINK 602
Query: 351 LKAEVKVRMDLERRLREAEGALRSLEQGLNSKVR-NKEKEERMRADVSHLKRFFEECIRN 409
LK + + ++ E + L + + ++ N E E+++ L+ +E +N
Sbjct: 603 LKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQN 662
Query: 410 AELEAKMPVIMKNSVYIHKAATRRIKSCRFHRRRSSTSWNDM-KPSQSFMTSQLDANNME 468
+ K+ V MK + + +KS + S+ + + + F++ + D E
Sbjct: 663 DQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKE 722
Query: 469 ELKEVAKRL 477
+ ++ K+L
Sbjct: 723 HITQLEKKL 731
Score = 53.5 bits (127), Expect = 4e-07
Identities = 87/358 (24%), Positives = 159/358 (44%), Gaps = 57/358 (15%)
Query: 149 IKSLEAQGLQLAKEKQEYLDKLMEETE-------ELCLQREQREELERL----NQVLEAE 197
+ LE +QL KEK++ L K M+E E + L + + ERL NQ L +
Sbjct: 1121 VNELEELQVQLQKEKKQ-LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNK 1179
Query: 198 KQQFEEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKT 257
+ E++ QE+++++++ + E V+Q +++ + + L +T +EL+ K
Sbjct: 1180 NNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSK--- 1236
Query: 258 LEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSR 317
+ +HL A+ G L ++ +Q+E QL E + +EK ++
Sbjct: 1237 ----QAETDHLILQASL------KGELEASQQQVEVYKIQLAE--ITSEKHKIHEHLKTS 1284
Query: 318 ALEEEREF--YSSQSQALQNSLQELTAEKQQAERELKA-EVKVRMDLERRLR------EA 368
A + +R Y + ALQ + AE+ E ++ +V+V L+++ E
Sbjct: 1285 AEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAET 1344
Query: 369 EGALRS---LEQGLNS-KVRNKEKEERMRADVSHLKRFFEECIRNAELEAKMPVIMKNSV 424
EGA + LE ++ K++ ++ + ++ +VS L+ E + LE ++ +
Sbjct: 1345 EGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSE--HDTLLERHNKMLQET-- 1400
Query: 425 YIHKAATRRIKSCRFHRRRSSTSWNDMKPSQSFMT-SQLDANNMEELKEVAKRLSRDQ 481
+ K A R K C S S N M S+ T SQL + N EV + RDQ
Sbjct: 1401 -VSKEAELREKLC------SIQSENMMMKSEHTQTVSQLTSQN-----EVLRNSFRDQ 1446
Score = 53.1 bits (126), Expect = 6e-07
Identities = 70/301 (23%), Positives = 123/301 (40%), Gaps = 34/301 (11%)
Query: 124 QTQWLEMLQESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQ 183
Q Q E LQE ++T + + + K+ + + L L K K+E D ET+ L LQ
Sbjct: 1193 QKQKQETLQE--EITSLQSSVQQYEEKNTKIKQL-LVKTKKELADSKQAETDHLILQASL 1249
Query: 184 REELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQE----------- 232
+ ELE Q +E K Q E+ E E +K E R L +Q
Sbjct: 1250 KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA 1309
Query: 233 KKELRHLTESLQ----QTLEELSIEKKKTLEMLE-----ENENHLQTLANQSEQPPPSGG 283
K E +T + + L +K K++ E + HL+ L +Q +
Sbjct: 1310 KAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQ 1369
Query: 284 LH-----SNLRQIEEKMQQLLE--EKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS 336
+ S L+ ++ + LLE K+L E KE E R + + E +S+ Q +
Sbjct: 1370 NNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQ-T 1428
Query: 337 LQELTAEKQQAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSKVRNKEKEERMRADV 396
+ +LT++ + + +V+ L+ R+ L+ + +++ + E R+ V
Sbjct: 1429 VSQLTSQNEVLRNSFRDQVR---HLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
Query: 397 S 397
S
Sbjct: 1486 S 1486
Score = 47.4 bits (111), Expect = 3e-05
Identities = 60/222 (27%), Positives = 102/222 (45%), Gaps = 33/222 (14%)
Query: 150 KSLEAQGLQLAKEKQEYLDKLMEETEELCLQREQR--------EELERLNQVLEAEKQQF 201
K LE Q L++ + K +DK +E + LQ+EQ+ ELE L L+ EK+Q
Sbjct: 1083 KLLEVQILEVQRAKA-MVDKELEAEK---LQKEQKIKEHATTVNELEELQVQLQKEKKQL 1138
Query: 202 EEVVQELRMEQEQIKRELELTARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEML 261
++ + +ELEL + + E+ E L + L + K +E L
Sbjct: 1139 QKTM-----------QELELVKKDAQQTTLMNMEIADY-ERLMKELNQKLTNKNNKIEDL 1186
Query: 262 EENENHLQTLANQSEQPPPSGGLHSNLRQIEE---KMQQLL--EEKLLAEKRMKENEE-- 314
E+ E +Q ++ Q + L S+++Q EE K++QLL +K LA+ + E +
Sbjct: 1187 EQ-EIKIQKQKQETLQEEIT-SLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLI 1244
Query: 315 RSRALEEEREFYSSQSQALQNSLQELTAEKQQAERELKAEVK 356
+L+ E E Q + + L E+T+EK + LK +
Sbjct: 1245 LQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAE 1286
Score = 46.6 bits (109), Expect = 5e-05
Identities = 53/266 (19%), Positives = 124/266 (46%), Gaps = 23/266 (8%)
Query: 159 LAKEKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRE 218
L K+ +E ++ +E +E+L Q + +++L + +E + FEE + L+ + + E
Sbjct: 152 LQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDE 211
Query: 219 LELTARCLKG-VEQEKKELRHLTESLQQTLEEL-SIEKKKTLEML-------EENENHLQ 269
+ T L+ +E + + SLQ+ L +L +I +++ E++ +E+E +
Sbjct: 212 KKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEIN 271
Query: 270 TLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREF---- 325
L E ++ + I++K + LE A ++ + L +E F
Sbjct: 272 KLNELKENLVKQ--CEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQV 329
Query: 326 YSSQSQALQNSLQELTAEKQQAEREL----KAEVKVRMDLERRLREAEGALRSLEQGLNS 381
+ + + L+++L+EL ++ + E+ ++K+ MD + E LE +N
Sbjct: 330 VNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINE 389
Query: 382 KVRNKEKE----ERMRADVSHLKRFF 403
+ KE++ E+++++++ L + F
Sbjct: 390 LLLAKEEQGCVIEKLKSELAGLNKQF 415
Score = 46.2 bits (108), Expect = 7e-05
Identities = 75/331 (22%), Positives = 133/331 (40%), Gaps = 53/331 (16%)
Query: 133 ESGKVTWKNAQLGEAMIKSLEAQGLQLAKEKQEYLDKLMEE----------------TEE 176
ES KV N L + KS+ + AK+++E+L+ L+++ +E
Sbjct: 1321 ESYKVRVHNV-LKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSEL 1379
Query: 177 LCLQREQREELERLNQVLE---AEKQQFEEVVQELRMEQEQIKRELELTARCLKGVEQE- 232
LQ E LER N++L+ +++ + E + ++ E +K E T L +
Sbjct: 1380 QTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVL 1439
Query: 233 ----KKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHS-- 286
+ ++RHL E ++T+E L + L + E L L N+ P S
Sbjct: 1440 RNSFRDQVRHLQEEHRKTVETLQ-------QQLSKMEAQLFQLKNEPTTRSPVSSQQSLK 1492
Query: 287 NLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS--------LQ 338
NLR+ LL+ + + + E Y+ + L NS L
Sbjct: 1493 NLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLW 1552
Query: 339 ELTAEKQQAERELKAEVKVRMDLERRLREAEGA-------LRSLEQGLNSKVRNKEKEER 391
K++ ++L + K L LRE E ++ L+ + RN+E+ E+
Sbjct: 1553 HAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER-EK 1611
Query: 392 MRADVSHLKRFFEECI---RNAELEAKMPVI 419
A++ +LK + I +E E +PVI
Sbjct: 1612 SAANLEYLKNVLLQFIFLKPGSERERLLPVI 1642
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.126 0.341
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,600,242
Number of Sequences: 37866
Number of extensions: 871462
Number of successful extensions: 21744
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 706
Number of HSP's successfully gapped in prelim test: 1298
Number of HSP's that attempted gapping in prelim test: 5644
Number of HSP's gapped (non-prelim): 7142
length of query: 506
length of database: 18,247,518
effective HSP length: 107
effective length of query: 399
effective length of database: 14,195,856
effective search space: 5664146544
effective search space used: 5664146544
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.