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Search of human proteins with 237681121
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|237681121 breast cancer 1, early onset isoform 3 [Homo
sapiens]
(1816 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|237681121 breast cancer 1, early onset isoform 3 [Homo sapiens] 3626 0.0
gi|6552299 breast cancer 1, early onset isoform 1 [Homo sapiens] 3626 0.0
gi|237681119 breast cancer 1, early onset isoform 2 [Homo sapiens] 3612 0.0
gi|237681123 breast cancer 1, early onset isoform 4 [Homo sapiens] 1008 0.0
gi|237681125 breast cancer 1, early onset isoform 5 [Homo sapiens] 828 0.0
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 73 2e-12
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 55 8e-07
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 48 1e-04
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 48 1e-04
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 48 1e-04
gi|122891872 microcephalin [Homo sapiens] 47 1e-04
gi|38016937 lemur tyrosine kinase 2 [Homo sapiens] 46 3e-04
gi|38373673 synaptonemal complex protein 2 [Homo sapiens] 46 3e-04
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 45 8e-04
gi|88759339 aster-associated protein [Homo sapiens] 44 0.002
gi|62241003 cardiomyopathy associated 5 [Homo sapiens] 43 0.002
gi|149363642 coiled-coil domain containing 144A [Homo sapiens] 43 0.002
gi|217330641 IWS1 homolog [Homo sapiens] 43 0.003
gi|155029546 phosphofurin acidic cluster sorting protein 2 isofo... 42 0.004
gi|4503593 epidermal growth factor receptor pathway substrate 15... 42 0.004
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 42 0.004
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 42 0.005
gi|22749515 coiled-coil domain containing 110 isoform a [Homo sa... 42 0.007
gi|150170670 piccolo isoform 2 [Homo sapiens] 41 0.009
gi|150378539 piccolo isoform 1 [Homo sapiens] 41 0.009
gi|118498356 kinectin 1 isoform a [Homo sapiens] 41 0.012
gi|118498368 kinectin 1 isoform c [Homo sapiens] 41 0.012
gi|33620775 kinectin 1 isoform a [Homo sapiens] 41 0.012
gi|229577185 epidermal growth factor receptor pathway substrate ... 41 0.012
gi|213972636 tumor protein p53 binding protein 1 isoform 1 [Homo... 41 0.012
>gi|237681121 breast cancer 1, early onset isoform 3 [Homo sapiens]
Length = 1816
Score = 3626 bits (9402), Expect = 0.0
Identities = 1816/1816 (100%), Positives = 1816/1816 (100%)
Query: 1 MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF 60
MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF
Sbjct: 1 MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF 60
Query: 61 AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT 120
AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT
Sbjct: 61 AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT 120
Query: 121 KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE 180
KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE
Sbjct: 121 KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE 180
Query: 181 FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN 240
FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN
Sbjct: 181 FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN 240
Query: 241 SSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPL 300
SSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPL
Sbjct: 241 SSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPL 300
Query: 301 CERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNA 360
CERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNA
Sbjct: 301 CERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNA 360
Query: 361 KVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRK 420
KVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRK
Sbjct: 361 KVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRK 420
Query: 421 KASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQK 480
KASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQK
Sbjct: 421 KASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQK 480
Query: 481 TPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPI 540
TPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPI
Sbjct: 481 TPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPI 540
Query: 541 SSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSS 600
SSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSS
Sbjct: 541 SSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSS 600
Query: 601 EEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPG 660
EEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPG
Sbjct: 601 EEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPG 660
Query: 661 SFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESS 720
SFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESS
Sbjct: 661 SFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESS 720
Query: 721 SISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTE 780
SISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTE
Sbjct: 721 SISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTE 780
Query: 781 GFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSA 840
GFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSA
Sbjct: 781 GFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSA 840
Query: 841 HSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIK 900
HSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIK
Sbjct: 841 HSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIK 900
Query: 901 GGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHS 960
GGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHS
Sbjct: 901 GGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHS 960
Query: 961 MSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDEN 1020
MSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDEN
Sbjct: 961 MSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDEN 1020
Query: 1021 IQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPY 1080
IQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPY
Sbjct: 1021 IQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPY 1080
Query: 1081 LISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELS 1140
LISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELS
Sbjct: 1081 LISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELS 1140
Query: 1141 RSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTV 1200
RSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTV
Sbjct: 1141 RSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTV 1200
Query: 1201 ATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLT 1260
ATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLT
Sbjct: 1201 ATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLT 1260
Query: 1261 ANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGE 1320
ANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGE
Sbjct: 1261 ANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGE 1320
Query: 1321 AASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSN 1380
AASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSN
Sbjct: 1321 AASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSN 1380
Query: 1381 SYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSK 1440
SYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSK
Sbjct: 1381 SYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSK 1440
Query: 1441 NKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDL 1500
NKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDL
Sbjct: 1441 NKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDL 1500
Query: 1501 TETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKV 1560
TETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKV
Sbjct: 1501 TETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKV 1560
Query: 1561 AESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYK 1620
AESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYK
Sbjct: 1561 AESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYK 1620
Query: 1621 FARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERK 1680
FARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERK
Sbjct: 1621 FARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERK 1680
Query: 1681 MLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLC 1740
MLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLC
Sbjct: 1681 MLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLC 1740
Query: 1741 GASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQC 1800
GASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQC
Sbjct: 1741 GASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQC 1800
Query: 1801 QELDTYLIPQIPHSHY 1816
QELDTYLIPQIPHSHY
Sbjct: 1801 QELDTYLIPQIPHSHY 1816
>gi|6552299 breast cancer 1, early onset isoform 1 [Homo sapiens]
Length = 1863
Score = 3626 bits (9402), Expect = 0.0
Identities = 1816/1816 (100%), Positives = 1816/1816 (100%)
Query: 1 MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF 60
MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF
Sbjct: 48 MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF 107
Query: 61 AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT 120
AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT
Sbjct: 108 AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT 167
Query: 121 KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE 180
KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE
Sbjct: 168 KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE 227
Query: 181 FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN 240
FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN
Sbjct: 228 FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN 287
Query: 241 SSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPL 300
SSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPL
Sbjct: 288 SSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPL 347
Query: 301 CERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNA 360
CERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNA
Sbjct: 348 CERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNA 407
Query: 361 KVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRK 420
KVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRK
Sbjct: 408 KVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRK 467
Query: 421 KASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQK 480
KASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQK
Sbjct: 468 KASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQK 527
Query: 481 TPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPI 540
TPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPI
Sbjct: 528 TPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPI 587
Query: 541 SSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSS 600
SSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSS
Sbjct: 588 SSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSS 647
Query: 601 EEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPG 660
EEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPG
Sbjct: 648 EEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPG 707
Query: 661 SFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESS 720
SFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESS
Sbjct: 708 SFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESS 767
Query: 721 SISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTE 780
SISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTE
Sbjct: 768 SISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTE 827
Query: 781 GFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSA 840
GFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSA
Sbjct: 828 GFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSA 887
Query: 841 HSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIK 900
HSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIK
Sbjct: 888 HSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIK 947
Query: 901 GGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHS 960
GGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHS
Sbjct: 948 GGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHS 1007
Query: 961 MSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDEN 1020
MSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDEN
Sbjct: 1008 MSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDEN 1067
Query: 1021 IQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPY 1080
IQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPY
Sbjct: 1068 IQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPY 1127
Query: 1081 LISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELS 1140
LISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELS
Sbjct: 1128 LISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELS 1187
Query: 1141 RSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTV 1200
RSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTV
Sbjct: 1188 RSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTV 1247
Query: 1201 ATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLT 1260
ATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLT
Sbjct: 1248 ATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLT 1307
Query: 1261 ANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGE 1320
ANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGE
Sbjct: 1308 ANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGE 1367
Query: 1321 AASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSN 1380
AASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSN
Sbjct: 1368 AASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSN 1427
Query: 1381 SYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSK 1440
SYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSK
Sbjct: 1428 SYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSK 1487
Query: 1441 NKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDL 1500
NKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDL
Sbjct: 1488 NKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDL 1547
Query: 1501 TETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKV 1560
TETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKV
Sbjct: 1548 TETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKV 1607
Query: 1561 AESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYK 1620
AESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYK
Sbjct: 1608 AESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYK 1667
Query: 1621 FARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERK 1680
FARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERK
Sbjct: 1668 FARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERK 1727
Query: 1681 MLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLC 1740
MLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLC
Sbjct: 1728 MLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLC 1787
Query: 1741 GASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQC 1800
GASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQC
Sbjct: 1788 GASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQC 1847
Query: 1801 QELDTYLIPQIPHSHY 1816
QELDTYLIPQIPHSHY
Sbjct: 1848 QELDTYLIPQIPHSHY 1863
>gi|237681119 breast cancer 1, early onset isoform 2 [Homo sapiens]
Length = 1884
Score = 3612 bits (9367), Expect = 0.0
Identities = 1815/1837 (98%), Positives = 1816/1837 (98%), Gaps = 21/1837 (1%)
Query: 1 MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF 60
MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF
Sbjct: 48 MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF 107
Query: 61 AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT 120
AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT
Sbjct: 108 AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT 167
Query: 121 KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE 180
KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE
Sbjct: 168 KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE 227
Query: 181 FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN 240
FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN
Sbjct: 228 FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN 287
Query: 241 SSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPL 300
SSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPL
Sbjct: 288 SSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPL 347
Query: 301 CERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNA 360
CERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNA
Sbjct: 348 CERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNA 407
Query: 361 KVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRK 420
KVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRK
Sbjct: 408 KVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRK 467
Query: 421 KASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQK 480
KASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQK
Sbjct: 468 KASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQK 527
Query: 481 TPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPI 540
TPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPI
Sbjct: 528 TPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPI 587
Query: 541 SSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSS 600
SSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSS
Sbjct: 588 SSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSS 647
Query: 601 EEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPG 660
EEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPG
Sbjct: 648 EEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPG 707
Query: 661 SFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESS 720
SFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESS
Sbjct: 708 SFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESS 767
Query: 721 SISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTE 780
SISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTE
Sbjct: 768 SISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTE 827
Query: 781 GFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSA 840
GFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSA
Sbjct: 828 GFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSA 887
Query: 841 HSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIK 900
HSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIK
Sbjct: 888 HSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIK 947
Query: 901 GGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHS 960
GGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHS
Sbjct: 948 GGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHS 1007
Query: 961 MSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDEN 1020
MSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDEN
Sbjct: 1008 MSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDEN 1067
Query: 1021 IQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPY 1080
IQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPY
Sbjct: 1068 IQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPY 1127
Query: 1081 LISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELS 1140
LISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELS
Sbjct: 1128 LISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELS 1187
Query: 1141 RSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTV 1200
RSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTV
Sbjct: 1188 RSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTV 1247
Query: 1201 ATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLT 1260
ATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLT
Sbjct: 1248 ATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLT 1307
Query: 1261 ANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGE 1320
ANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGE
Sbjct: 1308 ANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGE 1367
Query: 1321 AASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSN 1380
AASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSN
Sbjct: 1368 AASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSN 1427
Query: 1381 SYPSIISDSSALEDLRNPEQSTSEK---------------------AVLTSQKSSEYPIS 1419
SYPSIISDSSALEDLRNPEQSTSEK +VLTSQKSSEYPIS
Sbjct: 1428 SYPSIISDSSALEDLRNPEQSTSEKDSHIHGQRNNSMFSKRPREHISVLTSQKSSEYPIS 1487
Query: 1420 QNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQE 1479
QNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQE
Sbjct: 1488 QNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQE 1547
Query: 1480 ELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPE 1539
ELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPE
Sbjct: 1548 ELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPE 1607
Query: 1540 SARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERV 1599
SARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERV
Sbjct: 1608 SARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERV 1667
Query: 1600 NKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLG 1659
NKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLG
Sbjct: 1668 NKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLG 1727
Query: 1660 IAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEI 1719
IAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEI
Sbjct: 1728 IAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEI 1787
Query: 1720 CCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQ 1779
CCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQ
Sbjct: 1788 CCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQ 1847
Query: 1780 MCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY 1816
MCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY
Sbjct: 1848 MCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY 1884
>gi|237681123 breast cancer 1, early onset isoform 4 [Homo sapiens]
Length = 759
Score = 1008 bits (2606), Expect = 0.0
Identities = 549/765 (71%), Positives = 594/765 (77%), Gaps = 20/765 (2%)
Query: 1061 IKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAE 1120
++ +E + V+ + + + +++P+ + C LL+ + +
Sbjct: 6 LRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCK 65
Query: 1121 NDIK----ESSAVFSKSVQKGELSRSPSPF---THTHLAQGYRRGAKKLESSEENLSSED 1173
NDI + S FS+ V+ EL + F T A Y AKK +S E+L E
Sbjct: 66 NDITKRSLQESTRFSQLVE--ELLKIICAFQLDTGLEYANSYNF-AKKENNSPEHLKDEV 122
Query: 1174 EELPCFQHLLFGK--VNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAK 1231
+ + K + + P + T + LS L K + V +
Sbjct: 123 SIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIEL 182
Query: 1232 ASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDK 1291
S SE+T A+ S EL +T T+D + S+K+ + V ++
Sbjct: 183 GSDS---SEDTVNKATYCSVGDQELLQITPQ-GTRDEISLDSAKKAACEFSETDVTNTEH 238
Query: 1292 ELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRD 1351
S+++ T E E+ + GEAASGCESETSVSEDCSGLSSQSDILTTQQRD
Sbjct: 239 HQPSNNDLNTT---EKRAAERHPEKYQGEAASGCESETSVSEDCSGLSSQSDILTTQQRD 295
Query: 1352 TMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQ 1411
TMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEK VLTSQ
Sbjct: 296 TMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEK-VLTSQ 354
Query: 1412 KSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQ 1471
KSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQ
Sbjct: 355 KSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQ 414
Query: 1472 NRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESD 1531
NRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESD
Sbjct: 415 NRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESD 474
Query: 1532 PSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPE 1591
PSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPE
Sbjct: 475 PSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPE 534
Query: 1592 LTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCE 1651
LTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCE
Sbjct: 535 LTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCE 594
Query: 1652 RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDR 1711
RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDR
Sbjct: 595 RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDR 654
Query: 1712 KIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTED 1771
KIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTED
Sbjct: 655 KIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTED 714
Query: 1772 NGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY 1816
NGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY
Sbjct: 715 NGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY 759
Score = 436 bits (1121), Expect = e-121
Identities = 288/538 (53%), Positives = 323/538 (60%), Gaps = 51/538 (9%)
Query: 1 MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF 60
MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF
Sbjct: 48 MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF 107
Query: 61 AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT 120
AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT
Sbjct: 108 AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT 167
Query: 121 KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE 180
KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE
Sbjct: 168 KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE 227
Query: 181 FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN 240
FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQG + S E + S L +
Sbjct: 228 FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGEAASGCESE-TSVSEDCSGLSSQ- 285
Query: 241 SSLLLTKDR---------MNVEKAEFCNKSKQPGLARS-QHNRWAGSKETCNDRRTP--S 288
S +L T+ R + E AE +Q G S + D R P S
Sbjct: 286 SDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQS 345
Query: 289 TEKKV----------------DLNAD--PLCERKEWNKQKLPCSENPRDTE----DVPWI 326
T +KV L+AD + +K K P E ++ D W
Sbjct: 346 TSEKVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWY 405
Query: 327 TLNSSIQKVNEWFSRSDELLGSDDSHDGESE-------SNAKVADVLDVLNEVDEYSGSS 379
+ S N + +EL+ D + + E + D+ SG S
Sbjct: 406 MHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGIS 465
Query: 380 EKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAF 439
D SDP E +S RV S K+ + A P +H T+ G
Sbjct: 466 LFSDDPESDPSEDRAPESARV-GNIPSSTSALKVPQLKVAESAQSPAAAHTTDT--AGYN 522
Query: 440 VTEPQIIQERP-LTNKL----KRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQT 492
E + +E+P LT KR SGL PE+F+ A + + N T +T
Sbjct: 523 AMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEET 580
>gi|237681125 breast cancer 1, early onset isoform 5 [Homo sapiens]
Length = 699
Score = 828 bits (2138), Expect = 0.0
Identities = 463/679 (68%), Positives = 508/679 (74%), Gaps = 20/679 (2%)
Query: 1061 IKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAE 1120
++ +E + V+ + + + +++P+ + C LL+ + +
Sbjct: 6 LRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCK 65
Query: 1121 NDIK----ESSAVFSKSVQKGELSRSPSPF---THTHLAQGYRRGAKKLESSEENLSSED 1173
NDI + S FS+ V+ EL + F T A Y AKK +S E+L E
Sbjct: 66 NDITKRSLQESTRFSQLVE--ELLKIICAFQLDTGLEYANSYNF-AKKENNSPEHLKDEV 122
Query: 1174 EELPCFQHLLFGK--VNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAK 1231
+ + K + + P + T + LS L K + V +
Sbjct: 123 SIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIEL 182
Query: 1232 ASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDK 1291
S SE+T A+ S EL +T T+D + S+K+ + V ++
Sbjct: 183 GSDS---SEDTVNKATYCSVGDQELLQITPQ-GTRDEISLDSAKKAACEFSETDVTNTEH 238
Query: 1292 ELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRD 1351
S+++ T E E+ + GEAASGCESETSVSEDCSGLSSQSDILTTQQRD
Sbjct: 239 HQPSNNDLNTT---EKRAAERHPEKYQGEAASGCESETSVSEDCSGLSSQSDILTTQQRD 295
Query: 1352 TMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQ 1411
TMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEK VLTSQ
Sbjct: 296 TMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEK-VLTSQ 354
Query: 1412 KSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQ 1471
KSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQ
Sbjct: 355 KSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQ 414
Query: 1472 NRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESD 1531
NRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESD
Sbjct: 415 NRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESD 474
Query: 1532 PSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPE 1591
PSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPE
Sbjct: 475 PSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPE 534
Query: 1592 LTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCE 1651
LTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCE
Sbjct: 535 LTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCE 594
Query: 1652 RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDR 1711
RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDR
Sbjct: 595 RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDR 654
Query: 1712 KIFRGLEICCYGPFTNMPT 1730
KIFRGLEICCYGPFTNMPT
Sbjct: 655 KIFRGLEICCYGPFTNMPT 673
Score = 436 bits (1121), Expect = e-121
Identities = 288/538 (53%), Positives = 323/538 (60%), Gaps = 51/538 (9%)
Query: 1 MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF 60
MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF
Sbjct: 48 MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNF 107
Query: 61 AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT 120
AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT
Sbjct: 108 AKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRT 167
Query: 121 KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE 180
KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE
Sbjct: 168 KQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACE 227
Query: 181 FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHEN 240
FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQG + S E + S L +
Sbjct: 228 FSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGEAASGCESE-TSVSEDCSGLSSQ- 285
Query: 241 SSLLLTKDR---------MNVEKAEFCNKSKQPGLARS-QHNRWAGSKETCNDRRTP--S 288
S +L T+ R + E AE +Q G S + D R P S
Sbjct: 286 SDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQS 345
Query: 289 TEKKV----------------DLNAD--PLCERKEWNKQKLPCSENPRDTE----DVPWI 326
T +KV L+AD + +K K P E ++ D W
Sbjct: 346 TSEKVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWY 405
Query: 327 TLNSSIQKVNEWFSRSDELLGSDDSHDGESE-------SNAKVADVLDVLNEVDEYSGSS 379
+ S N + +EL+ D + + E + D+ SG S
Sbjct: 406 MHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGIS 465
Query: 380 EKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAF 439
D SDP E +S RV S K+ + A P +H T+ G
Sbjct: 466 LFSDDPESDPSEDRAPESARV-GNIPSSTSALKVPQLKVAESAQSPAAAHTTDT--AGYN 522
Query: 440 VTEPQIIQERP-LTNKL----KRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQT 492
E + +E+P LT KR SGL PE+F+ A + + N T +T
Sbjct: 523 AMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEET 580
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 73.2 bits (178), Expect = 2e-12
Identities = 132/659 (20%), Positives = 248/659 (37%), Gaps = 54/659 (8%)
Query: 955 NFEEHSM------SPEREMGNE--NIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNE 1006
+F++ SM S + GN+ N S ++ SR + N + + N ++ + ++
Sbjct: 454 DFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDD 513
Query: 1007 VGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEY 1066
S ++ +SD N G + K ++ G S ++ + +
Sbjct: 514 DSDSTSDTNNSDSNGNGNNGNDDNDKSDS--GKGKSDSSDSDSSDSSNSSDSSDSSDSDS 571
Query: 1067 EEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETPD-----DLLDDGEIKEDTSFAEN 1121
+ + ++D S SD+ + S S S++ D D D + K D+S +E+
Sbjct: 572 SDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSES 631
Query: 1122 DIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQH 1181
D +S SKS S S + + + + +SS+ + SS
Sbjct: 632 DSSDSD---SKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS-------- 680
Query: 1182 LLFGKVNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEE 1241
S S+ S + S N+ E+ S +S +D S+ + ++ S+
Sbjct: 681 ----------SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD--SDS 728
Query: 1242 TKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERG 1301
+ S S SS S+ D + ++N+ D SS + S SD SD
Sbjct: 729 SNSSDSSDSSNSSDSSDSSDSSNSSD-----SSDSSDSSNSSDSSDSSDSSDSSDSSNSS 783
Query: 1302 TGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQ 1361
+ +N + S SN ++++ +S S S S+ SD ++ D+ +
Sbjct: 784 DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSD--SSNSSDSSDSSNSSDS 841
Query: 1362 QEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQN 1421
+ ++ + S S+S S SDSS D N S+ S SS+ S N
Sbjct: 842 SDSSDSSDGSDSDSSNRSDSSNS--SDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSN 899
Query: 1422 PEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRN---YPSQ 1478
+ S+DSS S N E S+ S + D S S + N +
Sbjct: 900 SSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNS 959
Query: 1479 EELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAP 1538
+ D + +S + S + + +S S SD +S S D +
Sbjct: 960 SDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNS--SDSSDSSDSSDSSN 1017
Query: 1539 ESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTE 1597
S + SS S+ ++S+ S ++ ++D++ N+ + S S + + + S++
Sbjct: 1018 SSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS--NSSDSSDSSDSSDSSDSSD 1074
Score = 50.1 bits (118), Expect = 2e-05
Identities = 90/506 (17%), Positives = 180/506 (35%), Gaps = 24/506 (4%)
Query: 958 EHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSS 1017
+ S S N++ S+ S+ S N+ + ++S S+ + S+N SS N SS
Sbjct: 775 DSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSS-NSSDSS 833
Query: 1018 DENIQAELGRNR----GPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTV 1073
D + ++ + G ++ R S SN E +
Sbjct: 834 DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893
Query: 1074 NTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKS 1133
++D S SD+ + S + S D + ++++ +++ S+ S S
Sbjct: 894 SSDSSNSSDSDSSDSSNSSDSSD---SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950
Query: 1134 VQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQ 1193
+ S S + + + +S ++ S D ++ S
Sbjct: 951 SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSS------------DSSDSS 998
Query: 1194 STRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQC 1253
+ +S+ +++ + N NS +D SN + +S S+ + S S SS
Sbjct: 999 DSSNSSDSSDSSDSSDSSNSSDSSNS-SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1057
Query: 1254 SELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQS 1313
S+ D + ++++ D S S+S S S D + +++ S
Sbjct: 1058 SDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS 1117
Query: 1314 MDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQ 1373
DS+ + S S++S S D S S SD +++ D+ + + ++ +
Sbjct: 1118 SDSS-NSSDSSDSSDSSDSSDSSNSSDSSD--SSESSDSSDSSDSSDSSDSSDSSDSSDS 1174
Query: 1374 HGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVS 1433
S S+ S + + + + S S + +S S S + + + S
Sbjct: 1175 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNES 1234
Query: 1434 ADSSTSKNKEPGVERSSPSKCPSLDD 1459
+DSS S + S S D
Sbjct: 1235 SDSSDSSDSSDSSNSSDSSDSSDSSD 1260
Score = 38.5 bits (88), Expect = 0.060
Identities = 69/403 (17%), Positives = 142/403 (35%), Gaps = 5/403 (1%)
Query: 955 NFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEI 1014
N + S + + S S S ++ + + SSN ++ S++ SS +
Sbjct: 899 NSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN 958
Query: 1015 GSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVN 1074
S N N ++ S S+ + + + +
Sbjct: 959 SSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNS 1018
Query: 1075 TDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSV 1134
+D S S N SS +S + D D+S + + S + S
Sbjct: 1019 SDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1078
Query: 1135 QKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQS 1194
S S +++ + + +SS+ + SS+ + ++ S S
Sbjct: 1079 SDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1138
Query: 1195 TRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCS 1254
+ S + S ++ ++ S +S D S+ + +S + S+ + S S SS S
Sbjct: 1139 SNSSDSSDSSESSDSSDSSDSSDSS--DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1196
Query: 1255 ELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSM 1314
+ D + ++++ D S S+S SD SD + + +N + S
Sbjct: 1197 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSS--DSSDSNESSDSSDSSDSSDSSNSSDSSD 1254
Query: 1315 DSNLGEAASGCESET-SVSEDCSGLSSQSDILTTQQRDTMQHN 1356
S+ ++ S E+ S S+ +G ++ SD + + H+
Sbjct: 1255 SSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHS 1297
Score = 36.6 bits (83), Expect = 0.23
Identities = 67/384 (17%), Positives = 132/384 (34%), Gaps = 5/384 (1%)
Query: 960 SMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDE 1019
S S + +++ S S S ++ N + SSN ++ +S++ SS + S
Sbjct: 892 SDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSS 951
Query: 1020 NIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSP 1079
N + + S S+ + + ++D S
Sbjct: 952 NSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1011
Query: 1080 YLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGEL 1139
S N SS +S + D D+S + + S + S
Sbjct: 1012 SSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1071
Query: 1140 SRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHST 1199
S S + + + + +SS+ + SS+ + ++ S S+ S
Sbjct: 1072 SSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1131
Query: 1200 VATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDL 1259
+ S N+ ++ S ++S D S+ + +S S+ + S S SS S+ D
Sbjct: 1132 SSDSSDSSNSSDSSDSSESS--DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1189
Query: 1260 TANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLG 1319
+ ++++ D S S+S S S D + E++ S DS+
Sbjct: 1190 SDSSDSSDS---SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDS 1246
Query: 1320 EAASGCESETSVSEDCSGLSSQSD 1343
+S + S+ S + +SD
Sbjct: 1247 SNSSDSSDSSDSSDSTSDSNDESD 1270
Score = 33.9 bits (76), Expect = 1.5
Identities = 53/275 (19%), Positives = 105/275 (38%), Gaps = 30/275 (10%)
Query: 137 SDSSEDTVNKATYCSVGDQELLQITPQGT--RDEISLDSAKKAACEFSETDVTNTEHHQP 194
S SS D+ N + D + + D S DS+ + S++D +N+
Sbjct: 677 SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSD 736
Query: 195 SNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMN-VE 253
S+N ++++ + + S SN +++ SS ++S+ + D N +
Sbjct: 737 SSNSSDSSDSSDSSNSSDSSDSSDSSN---SSDSSDSSDSSDSSDSSNSSDSNDSSNSSD 793
Query: 254 KAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPC 313
++ N S + S + + ++ N + ++ D
Sbjct: 794 SSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSD------------------- 834
Query: 314 SENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVD 373
S N D+ D + +SS ++ +RSD SD S +S +++ +D D NE
Sbjct: 835 SSNSSDSSD----SSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSD-SNESS 889
Query: 374 EYSGSSEKIDLLASDPHEALICKSERVHSKSVESN 408
S SS+ + SD ++ S S +S+
Sbjct: 890 NSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSS 924
Score = 31.6 bits (70), Expect = 7.4
Identities = 47/277 (16%), Positives = 102/277 (36%), Gaps = 17/277 (6%)
Query: 137 SDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSN 196
S S D+ N + D + + S DS+ + +D +++ + SN
Sbjct: 731 SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS----DSSDSSDSSNSSDSN 786
Query: 197 NDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAE 256
+ N+++ + + S S+ ++++S + + S + + + ++
Sbjct: 787 DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSD 846
Query: 257 FCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPCSEN 316
+ S RS + + S ++ + + + D N N S N
Sbjct: 847 SSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESS-------NSSDSSDSSN 899
Query: 317 PRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVD--- 373
D++ + S N S S+ SD+S+ +S +++ +D D N D
Sbjct: 900 SSDSDSSDSSNSSDSSDSSNSSDS-SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN 958
Query: 374 --EYSGSSEKIDLLASDPHEALICKSERVHSKSVESN 408
+ S SS+ D +SD ++ S S +S+
Sbjct: 959 SSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSS 995
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 54.7 bits (130), Expect = 8e-07
Identities = 41/166 (24%), Positives = 76/166 (45%), Gaps = 15/166 (9%)
Query: 1583 ESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVM 1642
ES S + + +R + + ++ SGL+ E+ ++ + A THVV+
Sbjct: 550 ESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVV 609
Query: 1643 KTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGP 1702
DA + TLK LGI G W++ + WV ++ + E +E+ +GP
Sbjct: 610 PGDA---VQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEI---------PEGP 657
Query: 1703 KRARESQDR---KIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVV 1745
+R+R ++++ K+F G +G F + P D L +V G ++
Sbjct: 658 RRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQIL 703
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 47.8 bits (112), Expect = 1e-04
Identities = 131/665 (19%), Positives = 247/665 (37%), Gaps = 117/665 (17%)
Query: 85 NRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTV 144
++ KR QSE N + +S +G RT TK+RI K DSSED
Sbjct: 766 SKKKRQTQSESSNYDSELEKEIKSMSKIGAART--TKKRIPNTKDF-------DSSEDEK 816
Query: 145 NKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSNNDLNTTEK 204
+ + L+ + +G+ D+ ++ FS + T D +TT
Sbjct: 817 HSKKGMDNQGHKNLKTSQEGSSDDAERKQERET---FSSAEGTV---------DKDTTIM 864
Query: 205 RAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQP 264
+R P+K Q S+ ++ + G +SL E + TK++ K + C K Q
Sbjct: 865 ELRDRLPKKQQASASTDGVDKLSGKEQSFTSL--EVRKVAETKEKSKHLKTKTCKKV-QD 921
Query: 265 GLA-------------RSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKL 311
GL+ + + SK+ +++ PS KK + + E +KL
Sbjct: 922 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 981
Query: 312 PCSEN----PRDTEDVPWITLNS----------SIQKVNEWFSRSDELLGSDDSHDGESE 357
P E P+ + + T + + +K +E +++ G DS D +
Sbjct: 982 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1041
Query: 358 SNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKS---ERVHSKSVESNIEDKIF 414
+K Y ++ LL + C S E+ K N DK
Sbjct: 1042 KKSKNG----------AYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL 1091
Query: 415 GKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKR------------RPT 462
+ ++ + T+ + G+ ++ + E NK K++R +
Sbjct: 1092 KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSE---DNKKKKQRTSSKKKAVIVKEKKR 1148
Query: 463 SGLHPEDFIKKADLAVQKTPEM-------INQGTNQTEQNGQVM-NITNSGHEN--KTKG 512
+ L K+AD+ + ++ I +G++ ++ V N+ S H ++ G
Sbjct: 1149 NSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG 1208
Query: 513 DSIQNEKNPNPIESLEKES------AFKTKAEPISSSISNMELELNIHNSKAPKKNRLRR 566
D ++ P ++ + ++ A K E I +++S+ E + + P++ + R
Sbjct: 1209 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE---DGSSDDEPEEGKKRT 1265
Query: 567 KSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKE 626
E + ++ +S S SEE KK +Y +RH L + +G+
Sbjct: 1266 GKQNEENPGDEEAKN---------QVNSESDSDSEESKKPRYRHRLLRH--KLTVSDGE- 1313
Query: 627 PATGAKKSNKPNE--QTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEK 684
+G +K KP E + R+ E + F + + E+ E + PR
Sbjct: 1314 --SGEEKKTKPKEHKEVKGRNRRKVSSE---DSEDSDFQESGVSEEVSESEDEQRPRTRS 1368
Query: 685 EEKLE 689
+K E
Sbjct: 1369 AKKAE 1373
Score = 33.5 bits (75), Expect = 1.9
Identities = 95/500 (19%), Positives = 181/500 (36%), Gaps = 83/500 (16%)
Query: 285 RTPSTEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDE 344
R P+ V N+D C KQKL +D NSS ++ + ++
Sbjct: 627 RRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKR-------NSSDSAIDN--PKPNK 677
Query: 345 LLGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKS 404
L S S + S++ ++L +L EV S SS D ++ H + ++
Sbjct: 678 LPKSKQSETVDQNSDSD--EMLAILKEVSRMSHSSSS-DTDINEIH----TNHKTLYDLK 730
Query: 405 VESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSG 464
++ +DK GK RK ++ + F T+ + + +K KR+ + S
Sbjct: 731 TQAGKDDK--GKRKRKSSTSGS-----------DFDTKKGKSAKSSIISKKKRQTQSESS 777
Query: 465 LHPEDFIKK---------ADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSI 515
+ + K+ A ++ P + +++ E++ + + N GH+N
Sbjct: 778 NYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSK-KGMDNQGHKNL----KT 832
Query: 516 QNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRL--------RRK 567
E + + E ++ F + + + MEL + PKK + +
Sbjct: 833 SQEGSSDDAERKQERETFSSAEGTVDKDTTIMEL-----RDRLPKKQQASASTDGVDKLS 887
Query: 568 SSTRHIHALEL-------VVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQ 620
+ +LE+ S++L C ++Q +E+ KK + +
Sbjct: 888 GKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQS 947
Query: 621 ---LMEGKEPATGAKKSNKPNEQTSKRHD-SDTFPELKLTNAPGSFTKCSNTSELKEFVN 676
E K+P+ KK K +Q D ++ PE + C +K+ N
Sbjct: 948 KKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPERE--------EICHFPKGIKQIKN 999
Query: 677 PSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESI 736
+ E+K +K+ K S ++ D E+ S +SS YG ++
Sbjct: 1000 GTTDGEKKSKKIRD-KTSKKKDELSDY---AEKSTGKGDSCDSSEDKKSKNGAYGREKK- 1054
Query: 737 SLLEVSTLGKAKTEPNKCVS 756
LGK+ + C S
Sbjct: 1055 ---RCKLLGKSSRKRQDCSS 1071
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 47.8 bits (112), Expect = 1e-04
Identities = 131/665 (19%), Positives = 247/665 (37%), Gaps = 117/665 (17%)
Query: 85 NRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTV 144
++ KR QSE N + +S +G RT TK+RI K DSSED
Sbjct: 804 SKKKRQTQSESSNYDSELEKEIKSMSKIGAART--TKKRIPNTKDF-------DSSEDEK 854
Query: 145 NKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSNNDLNTTEK 204
+ + L+ + +G+ D+ ++ FS + T D +TT
Sbjct: 855 HSKKGMDNQGHKNLKTSQEGSSDDAERKQERET---FSSAEGTV---------DKDTTIM 902
Query: 205 RAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQP 264
+R P+K Q S+ ++ + G +SL E + TK++ K + C K Q
Sbjct: 903 ELRDRLPKKQQASASTDGVDKLSGKEQSFTSL--EVRKVAETKEKSKHLKTKTCKKV-QD 959
Query: 265 GLA-------------RSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKL 311
GL+ + + SK+ +++ PS KK + + E +KL
Sbjct: 960 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 1019
Query: 312 PCSEN----PRDTEDVPWITLNS----------SIQKVNEWFSRSDELLGSDDSHDGESE 357
P E P+ + + T + + +K +E +++ G DS D +
Sbjct: 1020 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1079
Query: 358 SNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKS---ERVHSKSVESNIEDKIF 414
+K Y ++ LL + C S E+ K N DK
Sbjct: 1080 KKSKNG----------AYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL 1129
Query: 415 GKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKR------------RPT 462
+ ++ + T+ + G+ ++ + E NK K++R +
Sbjct: 1130 KRIELRERRNLSSKRNTKEIQSGSSSSDAEESSE---DNKKKKQRTSSKKKAVIVKEKKR 1186
Query: 463 SGLHPEDFIKKADLAVQKTPEM-------INQGTNQTEQNGQVM-NITNSGHEN--KTKG 512
+ L K+AD+ + ++ I +G++ ++ V N+ S H ++ G
Sbjct: 1187 NSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG 1246
Query: 513 DSIQNEKNPNPIESLEKES------AFKTKAEPISSSISNMELELNIHNSKAPKKNRLRR 566
D ++ P ++ + ++ A K E I +++S+ E + + P++ + R
Sbjct: 1247 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE---DGSSDDEPEEGKKRT 1303
Query: 567 KSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKE 626
E + ++ +S S SEE KK +Y +RH L + +G+
Sbjct: 1304 GKQNEENPGDEEAKN---------QVNSESDSDSEESKKPRYRHRLLRH--KLTVSDGE- 1351
Query: 627 PATGAKKSNKPNE--QTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEK 684
+G +K KP E + R+ E + F + + E+ E + PR
Sbjct: 1352 --SGEEKKTKPKEHKEVKGRNRRKVSSE---DSEDSDFQESGVSEEVSESEDEQRPRTRS 1406
Query: 685 EEKLE 689
+K E
Sbjct: 1407 AKKAE 1411
Score = 33.5 bits (75), Expect = 1.9
Identities = 95/500 (19%), Positives = 181/500 (36%), Gaps = 83/500 (16%)
Query: 285 RTPSTEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDE 344
R P+ V N+D C KQKL +D NSS ++ + ++
Sbjct: 665 RRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKR-------NSSDSAIDN--PKPNK 715
Query: 345 LLGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKS 404
L S S + S++ ++L +L EV S SS D ++ H + ++
Sbjct: 716 LPKSKQSETVDQNSDSD--EMLAILKEVSRMSHSSSS-DTDINEIH----TNHKTLYDLK 768
Query: 405 VESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSG 464
++ +DK GK RK ++ + F T+ + + +K KR+ + S
Sbjct: 769 TQAGKDDK--GKRKRKSSTSGS-----------DFDTKKGKSAKSSIISKKKRQTQSESS 815
Query: 465 LHPEDFIKK---------ADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSI 515
+ + K+ A ++ P + +++ E++ + + N GH+N
Sbjct: 816 NYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSK-KGMDNQGHKNL----KT 870
Query: 516 QNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRL--------RRK 567
E + + E ++ F + + + MEL + PKK + +
Sbjct: 871 SQEGSSDDAERKQERETFSSAEGTVDKDTTIMEL-----RDRLPKKQQASASTDGVDKLS 925
Query: 568 SSTRHIHALEL-------VVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQ 620
+ +LE+ S++L C ++Q +E+ KK + +
Sbjct: 926 GKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQS 985
Query: 621 ---LMEGKEPATGAKKSNKPNEQTSKRHD-SDTFPELKLTNAPGSFTKCSNTSELKEFVN 676
E K+P+ KK K +Q D ++ PE + C +K+ N
Sbjct: 986 KKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPERE--------EICHFPKGIKQIKN 1037
Query: 677 PSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESI 736
+ E+K +K+ K S ++ D E+ S +SS YG ++
Sbjct: 1038 GTTDGEKKSKKIRD-KTSKKKDELSDY---AEKSTGKGDSCDSSEDKKSKNGAYGREKK- 1092
Query: 737 SLLEVSTLGKAKTEPNKCVS 756
LGK+ + C S
Sbjct: 1093 ---RCKLLGKSSRKRQDCSS 1109
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 47.8 bits (112), Expect = 1e-04
Identities = 185/1015 (18%), Positives = 365/1015 (35%), Gaps = 145/1015 (14%)
Query: 63 KENNSPEHLKDEVSIIQSMGYRNRA--KRLLQS--EPENPSLQETSLSVQLSN--LGTVR 116
++ + + LK+E+S +++ +A K+L Q E E LQ S QL + L T R
Sbjct: 369 EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428
Query: 117 TLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKK 176
L ++ + E D + + S +++L + T + LD K+
Sbjct: 429 QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ 488
Query: 177 AACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSL 236
E + T + + NDL ++ ++ + + NL + + S L
Sbjct: 489 QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK------IQNLEALLQKSKENISLL 542
Query: 237 QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLN 296
+ E L E A N+ T ++ T TEK + +
Sbjct: 543 EKEREDLYAKIQAGEGETAVL--------------NQLQEKNHTLQEQVTQLTEKLKNQS 588
Query: 297 ADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGE- 355
++ + Q + R +D ++L +S+ ++N + S E + D
Sbjct: 589 ESHKQAQENLHDQVQEQKAHLRAAQDRV-LSLETSVNELNSQLNESKEKVSQLDIQIKAK 647
Query: 356 -----SESNAKVADVLDVLNEVDEYSGS----SEKIDLLASDPHEALI-CKSERVHSKSV 405
S AK A D+ N +D + ++++ + + + + ++ H +
Sbjct: 648 TELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQL 707
Query: 406 ESNIED------KIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLK-RK 458
ES++++ + KT + + L + + + Q+R L L+ R
Sbjct: 708 ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767
Query: 459 RRPTSGLHPE-DFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQN 517
+ L E + + L +QK E + + + + I E ++ IQ+
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 518 EKNPNPIES---------LEKE------SAFKTKAEPISSSISNMELELNIHNSKAPKKN 562
E+ N I++ +EKE S K K +S S+ N + E N K
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 563 RLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLM 622
K+ H L++ + L +E+KK + H L+L
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLK-------------EQKELKKSLEKEKEASHQLKLELN 934
Query: 623 EGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPRE 682
+E A+ + K NE+ ++ G+ + +SE K+ +L E
Sbjct: 935 SMQEQLIQAQNTLKQNEKEEQQ-------------LQGNINELKQSSEQKKKQIEALQGE 981
Query: 683 EKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVS 742
K L+ ++ N + + L + + E + E IS++ +QE+ L+
Sbjct: 982 LKIAVLQKTELENKLQ--QQLTQAAQ-----ELAAEKEKISVLQNNYEKSQETFKQLQSD 1034
Query: 743 TLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEE 802
G+ ++E + E L NRN G + L E+ ++ T +E +
Sbjct: 1035 FYGR-ESELLATRQDLKSVEEKLSLAQEDLISNRNQI-GNQNKLIQELKTAKAT-LEQDS 1091
Query: 803 SELDAQYLQNTFK----VSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQ 858
++ + Q LQ K + K +S N + + A +K+ K+ E +
Sbjct: 1092 AKKE-QQLQERCKALQDIQKEKSLKE-KELVNEKSKLAEIEEIKCRQEKEITKLNEELKS 1149
Query: 859 KEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSR--FCLSSQFRGNET 916
+ K +N+K + + I + G+ D+ K +++ R L Q + E
Sbjct: 1150 HKLESIKEITNLKDAKQLLIQQKLELQGK----ADSLKAAVEQEKRNQQILKDQVKKEEE 1205
Query: 917 GLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMG----NENI 972
L KK +E+ + HS E+E+G EN
Sbjct: 1206 EL-----------------------------KKEFIEKEAKLHSEIKEKEVGMKKHEENE 1236
Query: 973 PSTVSTISRNNIRENVFK---EASSSNINEVGSSTNEVGSSINEIGSSDENIQAE 1024
I+ N K ++S ++E+ T+++ I + ++ +N Q E
Sbjct: 1237 AKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE 1291
Score = 38.1 bits (87), Expect = 0.079
Identities = 88/465 (18%), Positives = 182/465 (39%), Gaps = 57/465 (12%)
Query: 954 ENFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINE 1013
+ ++E +S E++ E + + + +++ KE + ++ + ++ E
Sbjct: 712 KEYKEKYLSLEQK--TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL-----E 764
Query: 1014 IGSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTV 1073
+ +++ + Q E+ + L+ E KQ L + +I KQ++E + Q
Sbjct: 765 LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE-EEKQILKQDFETLSQ-- 821
Query: 1074 NTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKS 1133
T +++ ++ + + +V E + + +K+ S + +K S + F K
Sbjct: 822 ETKIQHEELNNRIQTTV--TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879
Query: 1134 VQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQ 1193
QKG+ + T L +L+ EN E +EL
Sbjct: 880 NQKGKAAILDLEKTCKELKH-------QLQVQMENTLKEQKEL----------------- 915
Query: 1194 STRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQC 1253
+ L K E + LK LN Q+I A+ + + + EE + ++ +
Sbjct: 916 --------KKSLEKEKEAS-HQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
Query: 1254 SELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQS 1313
S + Q I ++ +++ Q + ++ ++E+ + L+ N ++ Q
Sbjct: 967 SSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026
Query: 1314 MDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQH-----NLIKLQQEMAELE 1368
L G ESE + L S + L+ Q D + + N KL QE+ +
Sbjct: 1027 TFKQLQSDFYGRESELLATR--QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAK 1084
Query: 1369 AVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKS 1413
A LEQ ++ + AL+D++ E+S EK L ++KS
Sbjct: 1085 ATLEQDSAKKEQ---QLQERCKALQDIQK-EKSLKEKE-LVNEKS 1124
>gi|122891872 microcephalin [Homo sapiens]
Length = 835
Score = 47.4 bits (111), Expect = 1e-04
Identities = 54/230 (23%), Positives = 91/230 (39%), Gaps = 40/230 (17%)
Query: 1591 ELTASTERVNKRMSMVVSGLTPEEFMLVYKFARK-HHITLTNLITEETTHVVMKTDAEFV 1649
EL S ++V++ + E+ +V + K ++ + E TTHV+
Sbjct: 636 ELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPL--- 692
Query: 1650 CERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEV-----RGDVVNGRNH--QGP 1702
RTL LGIA G WV+SY WV S++ ++E FE+ + H GP
Sbjct: 693 --RTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFELSHHFPAAPLCRSECHLSAGP 750
Query: 1703 KRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASV--VKELSSFTLGTGVHPI 1760
R +F P ++ P +L +V LCG V V +S +G
Sbjct: 751 YRG------TLFADQPAMFVSPASSPPVAKLCELVHLCGGRVSQVPRQASIVIGP----- 799
Query: 1761 VVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQ 1810
++ + ++ +WVLDS+ ++ + YL+ Q
Sbjct: 800 --------------YSGKKKATVKYLSEKWVLDSITQHKVCAPENYLLSQ 835
Score = 32.3 bits (72), Expect = 4.3
Identities = 76/332 (22%), Positives = 129/332 (38%), Gaps = 55/332 (16%)
Query: 544 ISNMELELN-IHNSKAPKKNRLRRKSSTRHIHAL---ELVVSRNLSPPNCTELQIDSCSS 599
IS++ L+ N IH+S P L + S + + L E+ + RN++ T Q +
Sbjct: 264 ISSLVLKANNIHSS--PSFTHLDKSSPQKFLSNLSKEEINLQRNIAGKVVTPDQKQAAGM 321
Query: 600 SEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKK-------SNKPNEQTSKRHDS---DT 649
S+E ++KY P S L+ P + + K S+ P ++ KR S
Sbjct: 322 SQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSHGSHSPPKEKCKRKRSTRRSI 381
Query: 650 FPELKLTNA---------PGSFTKCSNTSELKEFVNPSLPREEKEEKL--ETVKVSNNAE 698
P L+L + P S ++ +P +E E L E+ S+ A+
Sbjct: 382 MPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYFSPDNLKERYSENLPPESQLPSSPAQ 441
Query: 699 DPKDLMLSGERVLQTERS--VESSSISLVPGTDYGTQE--SISLLEVSTLGKAKTEPNKC 754
LS + + ER+ E S S V G T + + + +S+ K +
Sbjct: 442 ------LSCRSLSKKERTSIFEMSDFSCV-GKKTRTVDITNFTAKTISSPRKTGNGEGRA 494
Query: 755 VSQCAAFENPKGLIHGCSKDNRNDT----EGFKY-------PLGHEVNHS-RETSIEMEE 802
S C P+ + C + + D GF Y P GH+ + + E S+E +
Sbjct: 495 TSSCVT-SAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDDDLTPLEGSLEEMK 553
Query: 803 SELDAQYLQNTFKVSKRQSFAPFSNPGNAEEE 834
+ + QN SK + S+ G A+ E
Sbjct: 554 EAVGLKSTQNKGTTSKISN----SSEGEAQSE 581
>gi|38016937 lemur tyrosine kinase 2 [Homo sapiens]
Length = 1503
Score = 46.2 bits (108), Expect = 3e-04
Identities = 129/592 (21%), Positives = 215/592 (36%), Gaps = 90/592 (15%)
Query: 984 IRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGVLQ 1043
++ENV + +++ G + + S E+ + + E R P +++ G Q
Sbjct: 783 LQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPP-DSLPTQGETQ 841
Query: 1044 PEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETP 1103
P +P +C H +I V+ ++TD + + + + G S + +E+
Sbjct: 842 PTCLDVIVP-EDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESD 900
Query: 1104 DDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLE 1163
L DD I S S+ + PF+ H +RR K LE
Sbjct: 901 SVLADD-------------ILASRVSVGSSLPELGQELHNKPFSEDH--HSHRRLEKNLE 945
Query: 1164 SSE--ENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKN--TEENLLSLKNS 1219
+ E L+S+D G V+ + S ST ++ + LS E L +S
Sbjct: 946 AVETLNQLNSKDAAKEA------GLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDS 999
Query: 1220 LNDCSNQVILAKASQEH---HLSEETKCSASLFSSQCSELEDLTAN-----TNTQDPFLI 1271
L L + H L K + S + ++ E + T + T +P
Sbjct: 1000 LESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATT 1059
Query: 1272 GSSKQMRHQSESQGVGLSDKELVSD--DEERGTGLEENNQEEQSMDSNLGEAA-SGCESE 1328
G G+ + ++SD D RGT + S S A S +SE
Sbjct: 1060 GDGGH-------SGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSE 1112
Query: 1329 TSV-SEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIIS 1387
SE+ G S + +L +Q + +Q A ++ LE SQP S S +
Sbjct: 1113 PEKRSEEVPGTSPSALVLVQEQP---LPEPVLPEQSPAAQDSCLEARKSQPDESCLSALH 1169
Query: 1388 DSSALEDLRNPE--QSTSEKAVLTSQKSSEYPIS-QNPEGLSADKFEVSAD-----SSTS 1439
+SS LE PE Q+ + V ++ + P S N E S D FE D +ST
Sbjct: 1170 NSSDLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTG 1229
Query: 1440 KNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHD 1499
N + ++ + SL S+ +K D+E + L + G
Sbjct: 1230 TNTNELLAYTNSALDKSLSSH----------------SEGPKLKEPDIEGKYLGKLGVSG 1273
Query: 1500 LTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTS 1551
+ + S E G+ D E D + D + E R N+ S +S
Sbjct: 1274 MLDLS-------------EDGM----DADEEDENSDDSDEDLRAFNLHSLSS 1308
>gi|38373673 synaptonemal complex protein 2 [Homo sapiens]
Length = 1530
Score = 46.2 bits (108), Expect = 3e-04
Identities = 112/567 (19%), Positives = 223/567 (39%), Gaps = 95/567 (16%)
Query: 99 SLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELL 158
SL+ T+++ ++ R KQ I KTS++I + S+ V ++
Sbjct: 377 SLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES----------- 425
Query: 159 QITPQGTRDEISLDSAKKAACEFSETD--VTNTEHHQPSNNDLNTTEKRAAERHPEKYQG 216
QI+P G + +SL K+ EF++ + N++ +N+ L T P K +
Sbjct: 426 QISPVG-EELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTT-------PSKRKM 477
Query: 217 SSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAG 276
S S + V T S + N+S+ + R+ + + +++P ++++ NR
Sbjct: 478 SEASMI-VSGADRYTMRSPVLFSNTSIPPRRRRIK-PPLQMTSSAEKPSVSQTSENR-VD 534
Query: 277 SKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVN 336
+ + R + ++ +++ + + C EN T N +++ N
Sbjct: 535 NAASLKSRSSEGRHRRDNIDK---------HIKTAKCVEN----------TENKNVEFPN 575
Query: 337 EWFSRSDELLGSDDSHDGESESNAKVADVLDVL--NEVDEYSGSSEKIDLLASDPHEALI 394
+ FS +++ DS E + + VLD + N++ + + +
Sbjct: 576 QNFSELQDVI--PDSQAAEKRDHTILPGVLDNICGNKIHSKWACWTPVTNIE-------L 626
Query: 395 CKSERVHSKSVESNIEDKIFGKTYRKKASLPNLS-HVTENLIIGAFVTEPQIIQERPLTN 453
C ++R + S ++ +D + K K+ S ++S H +E T
Sbjct: 627 CNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEG------------------TG 668
Query: 454 KLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGD 513
K+K K+ T + I KA++ V K NQ N + +GQ EN + D
Sbjct: 669 KVKYKKEQTDHIK----IDKAEVEVCKKH---NQQQNHPKYSGQ------KNTENAKQSD 715
Query: 514 -SIQNEKNPNPI--ESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSST 570
+++E + +ES K +S ++ + N SK + +R K T
Sbjct: 716 WPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELT 775
Query: 571 RHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATG 630
+++ + + E + S +I K+ + ++ +R L KE
Sbjct: 776 SELNSWDSKQKKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKL-----KESLIN 830
Query: 631 AKKSNKPNEQTSK-RHDSDTFPELKLT 656
+ SNKP Q SK + ++ +LK T
Sbjct: 831 SGFSNKPVVQLSKEKVQKKSYRKLKTT 857
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 44.7 bits (104), Expect = 8e-04
Identities = 36/136 (26%), Positives = 69/136 (50%), Gaps = 17/136 (12%)
Query: 1276 QMRHQSESQGVGLSDKELVSDDEERGTGLEENN---QEEQSMDSNLGEAASGCESETSV- 1331
+++ Q + ++ EL + E T LE +N QE S ++ L E +SE +
Sbjct: 1362 KIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMM 1421
Query: 1332 ----SEDCSGLSSQSDILTTQQRDTMQH-------NLIKLQQEMAELEAVLEQHGSQPSN 1380
++ S L+SQ+++L RD ++H + LQQ+++++EA L Q ++P+
Sbjct: 1422 KSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTT 1481
Query: 1381 SYPSIISDSSALEDLR 1396
P +S +L++LR
Sbjct: 1482 RSP--VSSQQSLKNLR 1495
>gi|88759339 aster-associated protein [Homo sapiens]
Length = 647
Score = 43.5 bits (101), Expect = 0.002
Identities = 91/428 (21%), Positives = 165/428 (38%), Gaps = 75/428 (17%)
Query: 468 EDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNI-TNSGHENKTKGDSIQNEKNPNPIES 526
ED + K+ Q E + + + ++++I + S EN + + +P P
Sbjct: 122 EDIVVKSFSESQNKDEEFEKDKIKMKPKPRILSIKSTSSAENNSLDTDDHFKPSPRPRSM 181
Query: 527 LEKESAFKTK--AEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNL 584
L+K+S + K E +++S ELEL+ S P N ++ + A + S NL
Sbjct: 182 LKKKSHMEEKDGLEDKETALSE-ELELHSAPSSLPTPNGIQ-------LEAEKKAFSENL 233
Query: 585 SPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNK-PNEQTSK 643
P DSC +S + Q+ L + P + S K PNE+ ++
Sbjct: 234 DPE-------DSCLTS--LASSSLKQI---------LGDSFSPGSEGNASGKDPNEEITE 275
Query: 644 RHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDL 703
H+S E N SF+ T+ +++ KE ++ A+D ++
Sbjct: 276 NHNSLKSDE----NKENSFSADHVTTAVEK---------SKESQV-------TADDLEEE 315
Query: 704 MLSGERVLQTERSVE---SSSISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAA 760
E ++ +R+V+ S S S++ T T S +E + K+ N+ S A
Sbjct: 316 KAKAELIMDDDRTVDPLLSKSQSILISTS-ATASSKKTIEDRNIKNKKSTNNRASSASAR 374
Query: 761 FENPKGLIHGCSKDNRNDTEGFKYPLGH----EVNHSRETSIEMEES------------E 804
+ L SK T + LG + S++ SIE + + E
Sbjct: 375 LMTSEFLKKSSSKRRTPSTTTSSHYLGTLKVLDQKPSQKQSIEPDRADNIRAAVYQEWLE 434
Query: 805 LDAQYLQNTFKVSKRQSFA-----PFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQK 859
YL ++ + +S EE A+F A +K++ K+ + +
Sbjct: 435 KKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKKIAAKKRLE 494
Query: 860 EENQGKNE 867
E+N+ K E
Sbjct: 495 EKNKKKTE 502
>gi|62241003 cardiomyopathy associated 5 [Homo sapiens]
Length = 4069
Score = 43.1 bits (100), Expect = 0.002
Identities = 108/532 (20%), Positives = 184/532 (34%), Gaps = 95/532 (17%)
Query: 188 NTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTK 247
NTE PS D + + PE++ VS L VE + T +SS++ + +
Sbjct: 2025 NTELSWPSKED----SQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVE 2080
Query: 248 DRMNVEKAEFCNKSKQPGLARSQHNRWAGSK--ETCNDRRTPSTEKKVDLNADPLCE--- 302
+ EK + P + ++ SK + ++ + PS E K+ P+
Sbjct: 2081 PALGNEKEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHA 2140
Query: 303 RKEWNKQKLPCSENPRDTE-----DVPWITLNSSIQKVNEWFSR--------SDELLGSD 349
R+ + + ++NP D+P I W S +++ +
Sbjct: 2141 REPQSPESPEVTQNPPTQPKVAKPDLPEEKGKKGISSFKSWMSSLFFGSSTPDNKVAEQE 2200
Query: 350 DSHDGESESNAKVADVLDVLNEVDEYSGSSEK--------IDLLASDPHEALICKS---E 398
D S S K V+D + +EK + L +D + KS +
Sbjct: 2201 DLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVKLKTADEPRGTLVKSGDGQ 2260
Query: 399 RVHSKS-VESNIED----KIFGKTYRKKASLPNLSHVTENLIIGAFVT------------ 441
V KS + SN+ED K + R+ +S +E + I + VT
Sbjct: 2261 NVKEKSMILSNVEDLQQPKFISEVSREDYGKKEISGDSEEMNINSVVTSADGENLEIQSY 2320
Query: 442 ----EPQIIQER-----PLTNKLKRKRRPTSGL-----------HPEDFIKKADLAVQKT 481
E +++E P KR ++P P K+ L
Sbjct: 2321 SLIGEKLVMEEAKTIVPPHVTDSKRVQKPAIAPPSKWNISIFKEEPRSDQKQKSLLSFDV 2380
Query: 482 PEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPIS 541
+ + Q N NIT K + + E++ + ++ K P S
Sbjct: 2381 VDKVPQQPKSASSNFASKNITKESE--KPESIILPVEESKGSLIDFSEDRLKKEMQNPTS 2438
Query: 542 SSISNMELELNIHNSKAPKKNRLRRKSST-----------RHIHALELVVSRNLSPPNCT 590
IS E +L S KK+ L +S T + LEL S +
Sbjct: 2439 LKISEEETKLR-SVSPTEKKDNLENRSYTLAEKKVLAEKQNSVAPLELRDSNEIG----- 2492
Query: 591 ELQIDSCSSSEEIKKKKYNQMPVRHSRN------LQLMEGKEPATGAKKSNK 636
+ QI S S E+K+ K + MP +N +++ G E G +K N+
Sbjct: 2493 KTQITLGSRSTELKESKADAMPQHFYQNEDYNERPKIIVGSEKEKGEEKENQ 2544
Score = 42.7 bits (99), Expect = 0.003
Identities = 339/1655 (20%), Positives = 580/1655 (35%), Gaps = 298/1655 (18%)
Query: 72 KDEVSIIQSMGYRNRAKRLLQSEPENP----SLQETSLSVQLSNLGTVRTLRTKQRIQPQ 127
+D+V+I + +K L SE E SL S + S L V K +
Sbjct: 1416 EDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVI 1475
Query: 128 KTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVT 187
KTS SD SE+ V D++ L + + + + S KK+ SE V
Sbjct: 1476 KTSS--SQHSDKSEEA-------RVEDKQDLLFSTVCDSERL-VSSQKKSLMSTSE--VL 1523
Query: 188 NTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTK 247
EH P + E + E Q S ++ H+ P G + +S E +L
Sbjct: 1524 EPEHELPLSL---WGEIKKKETELPSSQNVSPASKHIIPKGKDEETASSSPELENLA--- 1577
Query: 248 DRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWN 307
GLA + +D+ P+ E D E+++
Sbjct: 1578 ----------------SGLAPTL-------LLLSDDKNKPAVEVSSTAQGDFPSEKQDVA 1614
Query: 308 KQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLD 367
+L +D P + L ++ + + R +G+ + +E+ V +
Sbjct: 1615 LAELSLEPEKKDKPHQP-LELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGP 1673
Query: 368 VLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNL 427
E+ G E +L AS A+ S + +S N E K F S
Sbjct: 1674 A--ELRSREGKEENRELCASSTMPAISELSSLLREES--QNEEIKPFSPKIISLESKEPP 1729
Query: 428 SHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQ 487
+ V E P+ Q P T LK S HP DF K + + P
Sbjct: 1730 ASVAEG-------GNPEEFQ--PFTFSLKGLSEEVS--HPADFKKGGNQEIGPLPPT--- 1775
Query: 488 GTNQTEQNGQVMNITN--SGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISSSIS 545
G + + G +++ + +GH N ++ ++S+ + S K P +
Sbjct: 1776 GNLKAQVMGDILDKLSEETGHPNSSQ-----------VLQSITEPS----KIAPSDLLVE 1820
Query: 546 NMELELNIHNSKAPKKNRLRRKSSTRHIHALEL--VVSRNLSPPNCTELQIDSCSSSEEI 603
+ E +H+ + K + S + ++ ++ NL + +E
Sbjct: 1821 QKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSLMRENLPLEQSKSFMTTKPADVKET 1880
Query: 604 KKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFT 663
K +++ P ++ M GK ++ + S + DS + EL+ + +
Sbjct: 1881 KMEEFFISP----KDENWMLGKPENVASQHEQRI--AGSVQLDSSSSNELRPGQLKAAVS 1934
Query: 664 KCSNTSELKEFVNPSLPREEKEEKLETVKVSNN--------------------AEDPKDL 703
+T E+++ V P E E V + AE+PK L
Sbjct: 1935 SKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSL 1994
Query: 704 MLSGERVLQTERSV-ESSSISLVPGTDYGTQESISLLEVSTLGKAKTE---PNKCVSQCA 759
+L+G ER++ E I + ES SLL L KA TE P+K SQ
Sbjct: 1995 VLAGN----VERNIAEGKEI-------HSLMESESLL----LEKANTELSWPSKEDSQEK 2039
Query: 760 A-------FENP-KGL---------IHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEE 802
F+ P GL I K EG + LG+E R T EE
Sbjct: 2040 IKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEE 2099
Query: 803 SELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEEN 862
L+ + + + +A+E KK SP+V ++K +
Sbjct: 2100 KPLEESKMVQSKVID------------DADEG-----------KKPSPEVKIPTQRKPIS 2136
Query: 863 Q---GKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRF--CLSSQFRGNETG 917
+ +S P T N P V + D P + K KG S F +SS F G+ T
Sbjct: 2137 SIHAREPQSPESPEVTQNPPTQ-PKVAKPDLPEEKGK---KGISSFKSWMSSLFFGSST- 2191
Query: 918 LITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFE------EHSMSPER-EMGNE 970
P+ Q P ++ V + + NF +HS+S + + +E
Sbjct: 2192 ---PDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVKLKTADE 2248
Query: 971 NIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRG 1030
+ V + N++E K SN+ ++ + I+E+ D + G +
Sbjct: 2249 PRGTLVKSGDGQNVKE---KSMILSNVEDL-----QQPKFISEVSREDYGKKEISGDSEE 2300
Query: 1031 PKLNAMLRLGVLQP-EVYKQSLPGSNCKHPEIKK------QEYEEVVQTVNTDFSPYLIS 1083
+N+++ + E+ SL G E K + + V + S + IS
Sbjct: 2301 MNINSVVTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHVTDSKRVQKPAIAPPSKWNIS 2360
Query: 1084 DNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDI-KESSAVFSKSVQKGELSRS 1142
E+P + S D + ++FA +I KES S + E S
Sbjct: 2361 IFKEEPRSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNITKESEKPESIILPVEESKGS 2420
Query: 1143 PSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVAT 1202
F+ L KK + +L +EE K +N+ ++S T+A
Sbjct: 2421 LIDFSEDRL--------KKEMQNPTSLKISEEETKLRSVSPTEKKDNLENRSY---TLAE 2469
Query: 1203 ECLSKNTEENL--LSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLT 1260
+ + + ++ L L++S Q+ L S E S+ + ++
Sbjct: 2470 KKVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTELKESKADAMPQHFYQNE-------- 2521
Query: 1261 ANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGE 1320
+ N + ++GS K+ + E+Q LS+ + QE Q N+ E
Sbjct: 2522 -DYNERPKIIVGSEKEKGEEKENQVYVLSE--------------GKKQQEHQPYSVNVAE 2566
Query: 1321 AASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAV------LEQH 1374
+ S ES+ S+ S S + T + + L + E+ E +AV LE+
Sbjct: 2567 SMSR-ESDISLGHSLGETQSFSLVKATSVTEKSEAMLAEAHPEIREAKAVGTQPHPLEES 2625
Query: 1375 GSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSA 1434
+ + S +++ N S S++ L +KSS + E + E+S
Sbjct: 2626 KVLVEKTKTFLPVALSCRDEIEN--HSLSQEGNLVLEKSSRDMPDHSEEKEQFRESELSK 2683
Query: 1435 DSSTSKNKE---PGVERSSPSKCP---------------------SLDDRWYMHSCS--G 1468
S KE G + + P S D HS S G
Sbjct: 2684 GGSVDITKETVKQGFQEKAVGTQPRPLEESKVLVEKTKTFLPVVLSCHDEIENHSLSQEG 2743
Query: 1469 SL----QNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLF 1524
+L +R+ P E + +E +L + G D+T+ S EG P ES +L
Sbjct: 2744 NLVLEKSSRDMPDHSE--EKEQFKESELWKGGSVDITKESM-----KEGFPSKESERTLA 2796
Query: 1525 SDDPESDPSEDR-------APESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAG 1577
E+ SE P++ G P +A+K ++ +E HT T+
Sbjct: 2797 RPFDETKSSETPPYLLSPVKPQTLASGASP-EINAVKKKEMPRSELTPERHTVHTIQTSK 2855
Query: 1578 YNAME---ESVSREKPELTASTE-RVNKRMSMVVS 1608
+ + +SV K L A+ + RV + +S S
Sbjct: 2856 DDTSDVPKQSVLVSKHHLEAAEDTRVKEPLSSAKS 2890
>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
Length = 1427
Score = 43.1 bits (100), Expect = 0.002
Identities = 62/283 (21%), Positives = 123/283 (43%), Gaps = 50/283 (17%)
Query: 1161 KLESSEENLSSEDEELPCFQHLLFGKVNNIPSQS-----TRHSTVATECLSKNTEENLLS 1215
K E E LS+ + ++ Q L + + +S + T+C K TE+
Sbjct: 964 KNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQI 1023
Query: 1216 LKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSK 1275
++ L + I + S E LS+ S ++ Q +L+D N+Q+ +S
Sbjct: 1024 EQSKLK----KYIAKQESVEERLSQLQ--SENMLLRQ--QLDDAHKKANSQEK----TSS 1071
Query: 1276 QMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESE------- 1328
++ Q S K L ++ E++ L+E N+E ++L E CE E
Sbjct: 1072 TIQDQFHSAA-----KNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKID 1126
Query: 1329 -----TSVSEDCSGLSSQSDILTTQQR-----------DTMQHNLIKLQQEMAELEAVLE 1372
+V C L +++++L QQ +T+Q N +L+QE+ L++ +E
Sbjct: 1127 LTEAQETVPSRCLHLDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYME 1186
Query: 1373 QHGSQPSNS-YPSIISDSSALEDLRNPEQSTSEKAVLTSQKSS 1414
++ + + + ++ + A +++ E+ +E A+LT QK +
Sbjct: 1187 RNMLERGKAEWHKLLIEERARKEI---EEKLNE-AILTLQKQA 1225
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 42.7 bits (99), Expect = 0.003
Identities = 77/333 (23%), Positives = 135/333 (40%), Gaps = 44/333 (13%)
Query: 1298 EERGTGLE-ENNQEEQSMDSNLGEAASGCESETSVSEDCSGL--------SSQSDILTTQ 1348
+ER +G + E++ EQ S+ G E+ETS ED GL S + L
Sbjct: 21 DERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRED--GLPKGHHVTDSENDEPLNLN 78
Query: 1349 QRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVL 1408
D+ L + + +E E E S N + S E+ R S SE L
Sbjct: 79 ASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEEL 138
Query: 1409 TSQKSSE---YPISQNPEGLS-ADKFEVS--ADSSTSKNKEPGVERSSPSKCPSLDDRWY 1462
+ +S+ + ++P S ++ + S +DS T +P + S + P
Sbjct: 139 LNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPP------- 191
Query: 1463 MHSCSGSLQNRNYP------SQEELIKVVDVEEQQLEESGPHDL--TETSYLPR-----Q 1509
H S S +N P S+ E + V + + EE H +E LP+
Sbjct: 192 RHQASDS-ENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDS 250
Query: 1510 DLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAES-AQSPA 1568
+ E P ++ S + P+ S+ + + R N S + ++P+ +V++S ++ P
Sbjct: 251 ESEDPPRHQASDSENEELPKPRISDSESEDPPR--NQASDSENEELPKPRVSDSESEGPQ 308
Query: 1569 AAHTTDTAGYNAMEESVSREKPELTASTERVNK 1601
+D+ +A S ++KPE ++R NK
Sbjct: 309 KGPASDSETEDA---SRHKQKPESDDDSDRENK 338
Score = 34.3 bits (77), Expect = 1.1
Identities = 86/422 (20%), Positives = 156/422 (36%), Gaps = 49/422 (11%)
Query: 957 EEHSMSPEREMGNENIPSTVSTISRNNIRENVFKE-ASSSNINEVG---SSTNEVGSSIN 1012
EE P + NE + + ++ S N E+V K AS S I E+ +S +E ++
Sbjct: 123 EETRKLPGSDSENEELLNGHASDSEN---EDVGKHPASDSEIEELQKSPASDSETEDALK 179
Query: 1013 EIGSSDENI-----QAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYE 1067
S E+ QA N P M + + LP E ++
Sbjct: 180 PQISDSESEEPPRHQASDSENEEPPKPRM-------SDSESEELPKPQVSDSESEEPPRH 232
Query: 1068 EVVQTVNTDFSPYLISDN-LEQPMGSSHASQVCSETPDDLLDDGEIKE----DTSFAEND 1122
+ + N + ISD+ E P + E P + D E ++ S +EN+
Sbjct: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENE 292
Query: 1123 IKESSAVF---SKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCF 1179
V S+ QKG S S + H + E+ E+ +++
Sbjct: 293 ELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSD 352
Query: 1180 QHLLFGKVNNIPSQSTRHSTV---ATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEH 1236
H+ K ++ S+ H + E + EE + K ++ S A A +
Sbjct: 353 SHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSR 412
Query: 1237 HLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQ----SESQGVGLSDKE 1292
+S+ + S + + E A+ + ++ S K+ + S+S+ G ++
Sbjct: 413 VVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSES-GNEEEN 471
Query: 1293 LVSD--------DEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDI 1344
L++D +EE TG + + EE+ ++ + EA E S S+D D
Sbjct: 472 LIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEA------EDSDSDDNIKRGKHMDF 525
Query: 1345 LT 1346
L+
Sbjct: 526 LS 527
>gi|155029546 phosphofurin acidic cluster sorting protein 2 isoform 2
[Homo sapiens]
Length = 889
Score = 42.4 bits (98), Expect = 0.004
Identities = 74/330 (22%), Positives = 124/330 (37%), Gaps = 50/330 (15%)
Query: 1250 SSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQ 1309
SSQ + ED T + +K + SE + S ++ SDD +G L+E+
Sbjct: 175 SSQPIDHEDSTMQAGPK-------AKSTDNYSEEEYESFSSEQEASDDAVQGQDLDED-- 225
Query: 1310 EEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEA 1369
D ++G+ S + +T QQ + ++ L + +
Sbjct: 226 -----DFDVGKPKKQRRSIVRTTS-----------MTRQQN--FKQKVVALLRRFKVSDE 267
Query: 1370 VLEQHGSQPSNSYPSIISDSSALED---LRNPEQS----TSEKAVLTSQKSSEYPISQNP 1422
VL+ P+ P D L D + +P S + +VL++ K P
Sbjct: 268 VLDSE-QDPAEHIPEAEEDLDLLYDTLDMEHPSDSGPDMEDDDSVLSTPKPKLRPYF--- 323
Query: 1423 EGLS--ADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQ-----NRNY 1475
EGLS + + E+ + S +KEP P K SL R S S ++ R +
Sbjct: 324 EGLSHSSSQTEIGSIHSARSHKEPPSPADVPEKTRSLGGRQPSDSVSDTVALGVPGPREH 383
Query: 1476 PSQEE-----LIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPES 1530
P Q E +DV ++L SG TE+ +P EG G S + ++
Sbjct: 384 PGQPEDSPEAEASTLDVFTERLPPSGRITKTESLVIPSTRSEGKQAGRRGRSTSLKERQA 443
Query: 1531 DPSEDRAPESARVGNIPSSTSALKVPQLKV 1560
++ S P + S L++P+ V
Sbjct: 444 ARPQNERANSLDNERCPDARSQLQIPRKTV 473
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 42.4 bits (98), Expect = 0.004
Identities = 71/325 (21%), Positives = 128/325 (39%), Gaps = 38/325 (11%)
Query: 1222 DCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQS 1281
D N I+ +++++ ++ K + SE++DL QD ++ + Q+
Sbjct: 336 DTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDL------QDEVQRENTNLQKLQA 389
Query: 1282 ESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQ 1341
+ Q V +EL+ + +E+ LEE +E + + + S ++E L+SQ
Sbjct: 390 QKQQV----QELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAE---------LTSQ 436
Query: 1342 SDILTTQQRDTMQ--HNLIKLQQEMAELE-------AVLEQHGSQPSNSYPSIISDSSAL 1392
++T + + + L +LQQE AELE A LE +S I S L
Sbjct: 437 ESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKL 496
Query: 1393 EDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPS 1452
++++ E S+ + SS + I N + D +S SS + N VE S
Sbjct: 497 MEMKDLENHNSQ----LNWCSSPHSILVNG---ATDYCSLSTSSSETANLNEHVEGQSNL 549
Query: 1453 KCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLE 1512
+ + S S L + E+ V + ++ H E +
Sbjct: 550 ESEPIHQESPARS-SPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSL 608
Query: 1513 GTPYLESGISLFSDDP--ESDPSED 1535
P ++ + F DP SDP +D
Sbjct: 609 TGPVADTNLDFFQSDPFVGSDPFKD 633
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 42.4 bits (98), Expect = 0.004
Identities = 65/274 (23%), Positives = 112/274 (40%), Gaps = 41/274 (14%)
Query: 1203 ECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTAN 1262
+CLSK E+ L L + +A+ +++HHL + K S L ++ +ELE L +
Sbjct: 1534 QCLSKKKEK----LTEELQKLQKDIEMAERNEDHHL-QVLKESEVLLQAKRAELEKLKSQ 1588
Query: 1263 TNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAA 1322
+Q + +Q+ H+ E + +G+ ++ ++++ E
Sbjct: 1589 VTSQQQEMAVLDRQLGHKKEELHL------------LQGSMVQAKADLQEALRLGETEVT 1636
Query: 1323 SGCESETSVSEDCSGLSSQSDILTTQ--QRDTMQHNLIK--LQQEMAELEAVLEQ---HG 1375
C V LS Q L Q +R T Q LIK +++E L+ VL Q H
Sbjct: 1637 EKCNHIREVKSLLEELSFQKGELNVQISERKT-QLTLIKQEIEKEEENLQVVLRQMSKHK 1695
Query: 1376 SQPSNSYPSIISDSSALE------DLRNPEQSTSEKAVLTSQKSSE--YPISQNPEG--- 1424
++ N + ++ L+ D R E ++ AVL + E ISQ +G
Sbjct: 1696 TELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIE 1755
Query: 1425 -----LSADKFEVSADSSTSKNKEPGVERSSPSK 1453
L DK E+ ++ S+ + VE S K
Sbjct: 1756 WQKQLLERDKREIERMTAESRALQSCVECLSKEK 1789
Score = 32.0 bits (71), Expect = 5.6
Identities = 60/349 (17%), Positives = 137/349 (39%), Gaps = 27/349 (7%)
Query: 1121 NDIKESSAVFSK-SVQKGELSR--SPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELP 1177
N I+E ++ + S QKGEL+ S T + Q + + L+ +S EL
Sbjct: 1640 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELK 1699
Query: 1178 CFQHLLFGKVNNIPSQSTRHSTVATEC-------LSKNTE-ENLLSLKNSLN---DCSNQ 1226
+L + + + +H +E L + E ENL + + Q
Sbjct: 1700 NILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQ 1759
Query: 1227 VILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGV 1286
++ + ++ E++ S E EDL + + L + + + E+ +
Sbjct: 1760 LLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM 1819
Query: 1287 GLSDKE-LVSDDEERGTGLEENNQEEQSMDSNLG----------EAASGCESETSVSEDC 1335
S+ E L + + L++ N+++ S+ +++ EA + + E + +D
Sbjct: 1820 EQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDH 1879
Query: 1336 SGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLE--QHGSQPSNSYPSIISDSSALE 1393
L+ Q + TT+ +D + +LQ++++E E Q + ++ +
Sbjct: 1880 LNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN 1939
Query: 1394 DLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNK 1442
L+ +Q + + ++S E + + L + ++ + + K+K
Sbjct: 1940 KLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSK 1988
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 42.0 bits (97), Expect = 0.005
Identities = 116/667 (17%), Positives = 232/667 (34%), Gaps = 70/667 (10%)
Query: 168 EISLDSAKKAACEFSETDVTNTEHHQPS--------NNDLNTTEKRAAERHPEKYQGSSV 219
E+ DS K E + + +P ++ + +K++ E P + +
Sbjct: 778 EVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDI 837
Query: 220 SNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKE 279
L G ++++E + K +N + F Q L+ S+ SKE
Sbjct: 838 RVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHF-----QQELSLSEKKNLTLSKE 892
Query: 280 TCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWF 339
+ D+ L +K N+++ + + ++ +++ ++
Sbjct: 893 V------QQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMH 946
Query: 340 SRSDELLGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSER 399
++ DEL D SN + ++ D+ N +E + + ++DLL +D + K R
Sbjct: 947 TKIDELRTLDSV---SQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYR 1003
Query: 400 VHSKSVESNIEDKIFG-----KTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNK 454
+ + E++ I K K +S SH E L + ++ + N+
Sbjct: 1004 IQEPNRENSFHSSIEAIWEECKEIVKASS--KKSHQIEELEQQIEKLQAEVKGYKDENNR 1061
Query: 455 LKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGT--------NQTEQNGQVMNITNSGH 506
LK K +D +K+ + +Q+ E + + + E + +T
Sbjct: 1062 LKEKEHKNQ----DDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVT 1117
Query: 507 ENKTKGDSIQNEKNPNPIES----------LEKESAF-------KTKAEPISSSISNMEL 549
K K ++ +E LEKES K E + S+ N +
Sbjct: 1118 CYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTK- 1176
Query: 550 ELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYN 609
+LN+ K ++ + H L+L + TE + S+S + N
Sbjct: 1177 DLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSA---RTQN 1233
Query: 610 QMPVRHSRNLQLMEGKEPATGAKKSNKP-NEQTSKRHDSDTFPELKLTNAPGSFTKCSNT 668
+ + KE T AKK K ++ S D D +K+ +CS
Sbjct: 1234 LKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQE 1293
Query: 669 SELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGT 728
++K+ L + +K+E + KDL + + + ++E + V
Sbjct: 1294 LDMKQRTIQQLKEQLNNQKVEEA-IQQYERACKDLNVKEKIIEDMRMTLEEQEQTQV--- 1349
Query: 729 DYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGH 788
Q+ + ++ + + TE K +C E +N D G L
Sbjct: 1350 ---EQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQD 1406
Query: 789 EVNHSRE 795
E+ S +
Sbjct: 1407 ELQESEQ 1413
>gi|22749515 coiled-coil domain containing 110 isoform a [Homo
sapiens]
Length = 833
Score = 41.6 bits (96), Expect = 0.007
Identities = 37/153 (24%), Positives = 66/153 (43%), Gaps = 3/153 (1%)
Query: 1305 EENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEM 1364
E+ ++EE +DS L A+ S V E + I ++ + Q L LQQ++
Sbjct: 4 EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQL 63
Query: 1365 AELEAVLEQHGSQPSNSYPSIISD--SSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNP 1422
+A L Q + S IS+ + ++ ++ NP+ S+ + V ++ + P
Sbjct: 64 ESFQA-LRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQE 122
Query: 1423 EGLSADKFEVSADSSTSKNKEPGVERSSPSKCP 1455
E LS +K DS T + E + S + P
Sbjct: 123 ENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLP 155
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 41.2 bits (95), Expect = 0.009
Identities = 61/309 (19%), Positives = 116/309 (37%), Gaps = 26/309 (8%)
Query: 1044 PEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETP 1103
P QSLP + K + K++ + P E + +SQ ++P
Sbjct: 1299 PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQ-PKSP 1357
Query: 1104 DDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKG----ELSRSPSPFTHTHLAQGYRRGA 1159
L D G + S + +I K + KG S+ SP + + LA+
Sbjct: 1358 QGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVL 1417
Query: 1160 KKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQS-----TRHSTVATECLSKNTEENLL 1214
LE+ L+ E E H + + ++ T T++ E + ++ EE
Sbjct: 1418 SILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEER-- 1475
Query: 1215 SLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSS 1274
K++ S Q I +S++H E + +E+ + + N+ P
Sbjct: 1476 --KDTFKKDSQQDI--PSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVP------ 1525
Query: 1275 KQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSED 1334
+ VG S + ++ +G+G EE+ +Q ++ + E ASG E + +
Sbjct: 1526 ----QRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQ 1581
Query: 1335 CSGLSSQSD 1343
+SS ++
Sbjct: 1582 LKEISSSTE 1590
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 41.2 bits (95), Expect = 0.009
Identities = 61/309 (19%), Positives = 116/309 (37%), Gaps = 26/309 (8%)
Query: 1044 PEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETP 1103
P QSLP + K + K++ + P E + +SQ ++P
Sbjct: 1299 PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQ-PKSP 1357
Query: 1104 DDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKG----ELSRSPSPFTHTHLAQGYRRGA 1159
L D G + S + +I K + KG S+ SP + + LA+
Sbjct: 1358 QGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVL 1417
Query: 1160 KKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQS-----TRHSTVATECLSKNTEENLL 1214
LE+ L+ E E H + + ++ T T++ E + ++ EE
Sbjct: 1418 SILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEER-- 1475
Query: 1215 SLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSS 1274
K++ S Q I +S++H E + +E+ + + N+ P
Sbjct: 1476 --KDTFKKDSQQDI--PSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVP------ 1525
Query: 1275 KQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSED 1334
+ VG S + ++ +G+G EE+ +Q ++ + E ASG E + +
Sbjct: 1526 ----QRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQ 1581
Query: 1335 CSGLSSQSD 1343
+SS ++
Sbjct: 1582 LKEISSSTE 1590
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 40.8 bits (94), Expect = 0.012
Identities = 114/645 (17%), Positives = 242/645 (37%), Gaps = 97/645 (15%)
Query: 923 KHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMG--NENIPSTVSTI- 979
+H + QN + + + + K + E E ++E G + + +T + +
Sbjct: 386 EHNVFQNKIHVS----YQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLE 441
Query: 980 SRNNIRENVFKEASSSNINEVGSSTN-----EVGSSINEIGSSDENIQAELGRNRGPKLN 1034
S+ + N ++ + +NE+ T EV E ++ +Q + R ++
Sbjct: 442 SKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQ 501
Query: 1035 AMLRLGVLQPEVYKQSLPG-------------SNCKHPEIKKQEYEEVV--------QTV 1073
+ +R + E +Q L S + KQ+ E+ + + V
Sbjct: 502 SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV 561
Query: 1074 NTDFSPYL-ISDNLEQPMG-----SSHASQVCSETPDDLL----------DDGEIK--ED 1115
N + S + + D LEQ SQ+ ++T +L D +IK ED
Sbjct: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED 621
Query: 1116 TSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEE 1175
+ +E D S K +Q LA A +LE ++++ +D++
Sbjct: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 1176 LPCFQHLLFGKVNN--------------IPSQSTRHSTVATECLSKNTEENL---LSLKN 1218
+ + L +++N + S+ + T+ +E +K+ E + + K+
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKD 741
Query: 1219 SLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPF--LIGSSKQ 1276
+++ Q EE + SS E++DL A N Q F L+ K+
Sbjct: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKK 801
Query: 1277 MRHQSESQGVG---LSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSE 1333
+ H+ + + L + EL+ + T +++ QE +++ +G
Sbjct: 802 VIHEKDGKIKSVEELLEAELLKVANKEKT-VQDLKQEIKALKEEIGNVQ----------- 849
Query: 1334 DCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALE 1393
L + T + +Q+ L +++M ++AVLE+ +N+ + E
Sbjct: 850 ----LEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE 905
Query: 1394 DLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSK 1453
L+ Q ++ + + +S++ + L + E+ + K +E + +
Sbjct: 906 SLKAHVQEVAQHNLKEASSASQF--EELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963
Query: 1454 CPSLDDRWYMHSCSGSLQNRNY------PSQEELIKVVDVEEQQL 1492
D+ S L+ +NY P EEL+KV+ E+++
Sbjct: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEI 1008
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 40.8 bits (94), Expect = 0.012
Identities = 114/645 (17%), Positives = 242/645 (37%), Gaps = 97/645 (15%)
Query: 923 KHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMG--NENIPSTVSTI- 979
+H + QN + + + + K + E E ++E G + + +T + +
Sbjct: 386 EHNVFQNKIHVS----YQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLE 441
Query: 980 SRNNIRENVFKEASSSNINEVGSSTN-----EVGSSINEIGSSDENIQAELGRNRGPKLN 1034
S+ + N ++ + +NE+ T EV E ++ +Q + R ++
Sbjct: 442 SKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQ 501
Query: 1035 AMLRLGVLQPEVYKQSLPG-------------SNCKHPEIKKQEYEEVV--------QTV 1073
+ +R + E +Q L S + KQ+ E+ + + V
Sbjct: 502 SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV 561
Query: 1074 NTDFSPYL-ISDNLEQPMG-----SSHASQVCSETPDDLL----------DDGEIK--ED 1115
N + S + + D LEQ SQ+ ++T +L D +IK ED
Sbjct: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED 621
Query: 1116 TSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEE 1175
+ +E D S K +Q LA A +LE ++++ +D++
Sbjct: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 1176 LPCFQHLLFGKVNN--------------IPSQSTRHSTVATECLSKNTEENL---LSLKN 1218
+ + L +++N + S+ + T+ +E +K+ E + + K+
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKD 741
Query: 1219 SLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPF--LIGSSKQ 1276
+++ Q EE + SS E++DL A N Q F L+ K+
Sbjct: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKK 801
Query: 1277 MRHQSESQGVG---LSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSE 1333
+ H+ + + L + EL+ + T +++ QE +++ +G
Sbjct: 802 VIHEKDGKIKSVEELLEAELLKVANKEKT-VQDLKQEIKALKEEIGNVQ----------- 849
Query: 1334 DCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALE 1393
L + T + +Q+ L +++M ++AVLE+ +N+ + E
Sbjct: 850 ----LEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE 905
Query: 1394 DLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSK 1453
L+ Q ++ + + +S++ + L + E+ + K +E + +
Sbjct: 906 SLKAHVQEVAQHNLKEASSASQF--EELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963
Query: 1454 CPSLDDRWYMHSCSGSLQNRNY------PSQEELIKVVDVEEQQL 1492
D+ S L+ +NY P EEL+KV+ E+++
Sbjct: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEI 1008
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 40.8 bits (94), Expect = 0.012
Identities = 114/645 (17%), Positives = 242/645 (37%), Gaps = 97/645 (15%)
Query: 923 KHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMG--NENIPSTVSTI- 979
+H + QN + + + + K + E E ++E G + + +T + +
Sbjct: 386 EHNVFQNKIHVS----YQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLE 441
Query: 980 SRNNIRENVFKEASSSNINEVGSSTN-----EVGSSINEIGSSDENIQAELGRNRGPKLN 1034
S+ + N ++ + +NE+ T EV E ++ +Q + R ++
Sbjct: 442 SKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQ 501
Query: 1035 AMLRLGVLQPEVYKQSLPG-------------SNCKHPEIKKQEYEEVV--------QTV 1073
+ +R + E +Q L S + KQ+ E+ + + V
Sbjct: 502 SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV 561
Query: 1074 NTDFSPYL-ISDNLEQPMG-----SSHASQVCSETPDDLL----------DDGEIK--ED 1115
N + S + + D LEQ SQ+ ++T +L D +IK ED
Sbjct: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED 621
Query: 1116 TSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEE 1175
+ +E D S K +Q LA A +LE ++++ +D++
Sbjct: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 1176 LPCFQHLLFGKVNN--------------IPSQSTRHSTVATECLSKNTEENL---LSLKN 1218
+ + L +++N + S+ + T+ +E +K+ E + + K+
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKD 741
Query: 1219 SLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPF--LIGSSKQ 1276
+++ Q EE + SS E++DL A N Q F L+ K+
Sbjct: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKK 801
Query: 1277 MRHQSESQGVG---LSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSE 1333
+ H+ + + L + EL+ + T +++ QE +++ +G
Sbjct: 802 VIHEKDGKIKSVEELLEAELLKVANKEKT-VQDLKQEIKALKEEIGNVQ----------- 849
Query: 1334 DCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALE 1393
L + T + +Q+ L +++M ++AVLE+ +N+ + E
Sbjct: 850 ----LEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE 905
Query: 1394 DLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSK 1453
L+ Q ++ + + +S++ + L + E+ + K +E + +
Sbjct: 906 SLKAHVQEVAQHNLKEASSASQF--EELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963
Query: 1454 CPSLDDRWYMHSCSGSLQNRNY------PSQEELIKVVDVEEQQL 1492
D+ S L+ +NY P EEL+KV+ E+++
Sbjct: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEI 1008
>gi|229577185 epidermal growth factor receptor pathway substrate 15
isoform B [Homo sapiens]
Length = 582
Score = 40.8 bits (94), Expect = 0.012
Identities = 68/320 (21%), Positives = 127/320 (39%), Gaps = 38/320 (11%)
Query: 1227 VILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGV 1286
++ + +++++ ++ K + SE++DL QD ++ + Q++ Q V
Sbjct: 27 IVCWSSREKNNVEQDLKEKEDTIKQRTSEVQDL------QDEVQRENTNLQKLQAQKQQV 80
Query: 1287 GLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILT 1346
+EL+ + +E+ LEE +E + + + S ++E L+SQ ++
Sbjct: 81 ----QELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAE---------LTSQESQIS 127
Query: 1347 TQQRDTMQ--HNLIKLQQEMAELE-------AVLEQHGSQPSNSYPSIISDSSALEDLRN 1397
T + + + L +LQQE AELE A LE +S I S L ++++
Sbjct: 128 TYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 187
Query: 1398 PEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSL 1457
E S+ + SS + I N + D +S SS + N VE S + +
Sbjct: 188 LENHNSQ----LNWCSSPHSILVNG---ATDYCSLSTSSSETANLNEHVEGQSNLESEPI 240
Query: 1458 DDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYL 1517
S S L + E+ V + ++ H E + P
Sbjct: 241 HQESPARS-SPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVA 299
Query: 1518 ESGISLFSDDP--ESDPSED 1535
++ + F DP SDP +D
Sbjct: 300 DTNLDFFQSDPFVGSDPFKD 319
>gi|213972636 tumor protein p53 binding protein 1 isoform 1 [Homo
sapiens]
Length = 1977
Score = 40.8 bits (94), Expect = 0.012
Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 15/140 (10%)
Query: 1283 SQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQS 1342
S +G+S + + +EE+G LE+ +E++ E SG + + +ED +
Sbjct: 123 SSVLGMSVESAPAVEEEKGEELEQKEKEKE-------EDTSGNTTHSLGAEDTASSQLGF 175
Query: 1343 DILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQST 1402
+L Q ++ N + + + +L++V +NS + +SD A +++ EQS
Sbjct: 176 GVLELSQSQDVEENTVPYEVDKEQLQSV-------TTNSGYTRLSDVDANTAIKHEEQS- 227
Query: 1403 SEKAVLTSQKSSEYPISQNP 1422
+E + Q S + P++ P
Sbjct: 228 NEDIPIAEQSSKDIPVTAQP 247
Score = 34.3 bits (77), Expect = 1.1
Identities = 55/264 (20%), Positives = 107/264 (40%), Gaps = 28/264 (10%)
Query: 1205 LSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASL----------FSSQCS 1254
+ K+ E +LS + L D SN+ + + EE CS + S Q S
Sbjct: 296 IQKSPEPEVLSTQEDLFDQSNKTVSSDGCSTPS-REEGGCSLASTPATTLHLLQLSGQRS 354
Query: 1255 ELEDLTANTNTQD-----PFLIGSSKQMRHQSESQGVGLSDKELVSD--DEERGTGLEEN 1307
++D + +TN+ D P S+ + S ++ G DK + + EE G ++
Sbjct: 355 LVQD-SLSTNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKK 413
Query: 1308 NQEEQSMDSN----LGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQE 1363
Q + ++ L E+ ++ T +S+ S + +Q + H++
Sbjct: 414 LQSGEPVELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQ--FSHDIFIPSPS 471
Query: 1364 MAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQ---STSEKAVLTSQKSSEYPISQ 1420
+ E ++ G S+S S +S +E +PE S + + +SEY S
Sbjct: 472 LEEQSNDGKKDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSP 531
Query: 1421 NPEGLSADKFEVSADSSTSKNKEP 1444
E LS+ + + +++ ++ EP
Sbjct: 532 KMESLSSHRIDEDGENTQIEDTEP 555
Score = 33.1 bits (74), Expect = 2.5
Identities = 35/146 (23%), Positives = 61/146 (41%), Gaps = 13/146 (8%)
Query: 1652 RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDR 1711
RT KYFL +A G VS+ WV S ++ N ++ ++ +R + Q R
Sbjct: 1816 RTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNY-----LLPAGYSLEEQRILDWQPR 1870
Query: 1712 K-IFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFT----LGTGVHPIVVVQPD 1766
+ F+ L++ + ++ GA+ VK+ S + GV +VV P
Sbjct: 1871 ENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVVVTDPS 1930
Query: 1767 AWTEDNGFHAIGQMCEAPVVTREWVL 1792
+ + PVV++EWV+
Sbjct: 1931 C---PASVLKCAEALQLPVVSQEWVI 1953
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.349
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,480,865
Number of Sequences: 37866
Number of extensions: 3294782
Number of successful extensions: 11128
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 285
Number of HSP's that attempted gapping in prelim test: 10473
Number of HSP's gapped (non-prelim): 993
length of query: 1816
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1699
effective length of database: 13,817,196
effective search space: 23475416004
effective search space used: 23475416004
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.