Search of human proteins with 23510448

Search of human proteins with 23510448

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23510448 minichromosome maintenance complex component 5
[Homo sapiens]
         (734 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23510448 minichromosome maintenance complex component 5 [Homo...  1447   0.0  
gi|33469919 minichromosome maintenance complex component 4 [Homo...   326   4e-89
gi|33469917 minichromosome maintenance complex component 4 [Homo...   326   4e-89
gi|33356547 minichromosome maintenance complex component 2 [Homo...   323   4e-88
gi|33469968 minichromosome maintenance complex component 7 isofo...   310   4e-84
gi|7427519 minichromosome maintenance complex component 6 [Homo ...   291   2e-78
gi|6631095 minichromosome maintenance complex component 3 [Homo ...   289   7e-78
gi|33469922 minichromosome maintenance complex component 7 isofo...   282   9e-76
gi|33469924 minichromosome maintenance complex component 8 isofo...   247   2e-65
gi|19923727 minichromosome maintenance complex component 8 isofo...   245   1e-64
gi|23397546 minichromosome maintenance complex component 9 [Homo...   107   4e-23
gi|188528675 slit homolog 1 [Homo sapiens]                             35   0.33 
gi|23957690 component of oligomeric golgi complex 7 [Homo sapiens]     34   0.42 
gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens]          33   0.72 
gi|221316624 dystonin isoform 4 [Homo sapiens]                         33   0.95 
gi|221316622 dystonin isoform 3 [Homo sapiens]                         33   0.95 
gi|221316618 dystonin isoform 2 [Homo sapiens]                         33   0.95 
gi|34577047 dystonin isoform 1 [Homo sapiens]                          33   0.95 
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]              33   0.95 
gi|51093861 caspase recruitment domain protein 10 [Homo sapiens]       33   1.2  
gi|54792146 tripartite motif-containing 47 [Homo sapiens]              32   1.6  
gi|13569840 MACRO domain containing 1 [Homo sapiens]                   32   2.1  
gi|31563531 stromal antigen 2 isoform b [Homo sapiens]                 32   2.1  
gi|112789530 stromal antigen 2 isoform b [Homo sapiens]                32   2.1  
gi|112789528 stromal antigen 2 isoform a [Homo sapiens]                32   2.1  
gi|112789526 stromal antigen 2 isoform a [Homo sapiens]                32   2.1  
gi|169234949 CWF19-like 2, cell cycle control [Homo sapiens]           32   2.1  
gi|111038124 succinate dehydrogenase complex assembly factor 1 [...    31   3.6  
gi|40806170 spastin isoform 2 [Homo sapiens]                           31   4.7  
gi|11875211 spastin isoform 1 [Homo sapiens]                           31   4.7  

>gi|23510448 minichromosome maintenance complex component 5 [Homo
           sapiens]
          Length = 734

 Score = 1447 bits (3746), Expect = 0.0
 Identities = 734/734 (100%), Positives = 734/734 (100%)

Query: 1   MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK 60
           MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK
Sbjct: 1   MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK 60

Query: 61  RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV 120
           RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
Sbjct: 61  RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV 120

Query: 121 LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLT 180
           LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLT
Sbjct: 121 LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLT 180

Query: 181 NIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGE 240
           NIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGE
Sbjct: 181 NIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGE 240

Query: 241 MPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ 300
           MPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ
Sbjct: 241 MPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ 300

Query: 301 VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGG 360
           VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGG
Sbjct: 301 VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGG 360

Query: 361 SRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR 420
           SRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR
Sbjct: 361 SRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR 420

Query: 421 DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS 480
           DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS
Sbjct: 421 DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS 480

Query: 481 RCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH 540
           RCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH
Sbjct: 481 RCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH 540

Query: 541 VSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS 600
           VSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS
Sbjct: 541 VSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS 600

Query: 601 DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV 660
           DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV
Sbjct: 601 DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV 660

Query: 661 EGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGE 720
           EGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGE
Sbjct: 661 EGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGE 720

Query: 721 IQHRMQRKVLYRLK 734
           IQHRMQRKVLYRLK
Sbjct: 721 IQHRMQRKVLYRLK 734


>gi|33469919 minichromosome maintenance complex component 4 [Homo
           sapiens]
          Length = 863

 Score =  326 bits (836), Expect = 4e-89
 Identities = 230/677 (33%), Positives = 344/677 (50%), Gaps = 55/677 (8%)

Query: 26  ARKSQLQRRFKEFLRQYRVGTDRTGFTFK---YRDELKRHYNLGEYWIEVEMEDLASFDE 82
           A K   QR  + F+       +  G       Y   L     +GE ++ V  E + SFD+
Sbjct: 161 ACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDK 220

Query: 83  DLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKS 142
           +L   L   P E +   + A  E+  +    R     +   IQV   +     ++R+L  
Sbjct: 221 NLYRQLISYPQEVIPTFDMAVNEIFFD----RYPDSILEHQIQVRPFNALKTKNMRNLNP 276

Query: 143 DMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQA 202
           + +  L+ I G++I  S +  +      QC+ C +T T + M  G    A P  C     
Sbjct: 277 EDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHT-TRVEMDRGR--IAEPSVCGRCHT 333

Query: 203 GRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNR 262
                 +    +  DK      Q +KLQE P+ +P G+ P  + L+    L DKV PG+R
Sbjct: 334 THSMALIHNRSLFSDK------QMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDR 387

Query: 263 VTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEF 322
           V + GIY          R   RV   ++S Y   + +        +   G     E++ F
Sbjct: 388 VNVTGIYRAVPI-----RVNPRVS-NVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLF 441

Query: 323 --------RRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRG- 373
                   + L+  P++YE ++ ++APSI+   D+KK I   LFGG+RK      T RG 
Sbjct: 442 SEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSH--TGRGK 499

Query: 374 ---DINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIME 430
              +IN+L+ GDPGT+KSQLL++V    P G YTSGKGSSA GLTA VM+DP +R  +++
Sbjct: 500 FRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQ 559

Query: 431 GGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANS 490
            GA+VL+D G+ CIDEFDKM E  R  +HE MEQQT+SIAKAGI   LN+R SVLAAAN 
Sbjct: 560 TGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANP 619

Query: 491 VFGRWDETKGE-DNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQA 549
           +  +W+  K   +NI    T+LSRFD+IF++ D  +E  D  LA H++ L+    ++ QA
Sbjct: 620 IESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQ--SEEQA 677

Query: 550 VEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPIT 609
            E  +D+A LK +IAY      PRLS EA++ L   Y+ MR       +    R  +   
Sbjct: 678 EEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMR-------KIGSSRGMVSAY 730

Query: 610 VRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAA---------LSGTLSGV 660
            RQLE+++R+AEA +K++L       DVEEA RL + +   +A         +S   +G+
Sbjct: 731 PRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGM 790

Query: 661 EGFTSQEDQEMLSRIEK 677
              + +  +E+   ++K
Sbjct: 791 SATSRKRKEELAEALKK 807


>gi|33469917 minichromosome maintenance complex component 4 [Homo
           sapiens]
          Length = 863

 Score =  326 bits (836), Expect = 4e-89
 Identities = 230/677 (33%), Positives = 344/677 (50%), Gaps = 55/677 (8%)

Query: 26  ARKSQLQRRFKEFLRQYRVGTDRTGFTFK---YRDELKRHYNLGEYWIEVEMEDLASFDE 82
           A K   QR  + F+       +  G       Y   L     +GE ++ V  E + SFD+
Sbjct: 161 ACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDK 220

Query: 83  DLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKS 142
           +L   L   P E +   + A  E+  +    R     +   IQV   +     ++R+L  
Sbjct: 221 NLYRQLISYPQEVIPTFDMAVNEIFFD----RYPDSILEHQIQVRPFNALKTKNMRNLNP 276

Query: 143 DMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQA 202
           + +  L+ I G++I  S +  +      QC+ C +T T + M  G    A P  C     
Sbjct: 277 EDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHT-TRVEMDRGR--IAEPSVCGRCHT 333

Query: 203 GRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNR 262
                 +    +  DK      Q +KLQE P+ +P G+ P  + L+    L DKV PG+R
Sbjct: 334 THSMALIHNRSLFSDK------QMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDR 387

Query: 263 VTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEF 322
           V + GIY          R   RV   ++S Y   + +        +   G     E++ F
Sbjct: 388 VNVTGIYRAVPI-----RVNPRVS-NVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLF 441

Query: 323 --------RRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRG- 373
                   + L+  P++YE ++ ++APSI+   D+KK I   LFGG+RK      T RG 
Sbjct: 442 SEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSH--TGRGK 499

Query: 374 ---DINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIME 430
              +IN+L+ GDPGT+KSQLL++V    P G YTSGKGSSA GLTA VM+DP +R  +++
Sbjct: 500 FRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQ 559

Query: 431 GGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANS 490
            GA+VL+D G+ CIDEFDKM E  R  +HE MEQQT+SIAKAGI   LN+R SVLAAAN 
Sbjct: 560 TGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANP 619

Query: 491 VFGRWDETKGE-DNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQA 549
           +  +W+  K   +NI    T+LSRFD+IF++ D  +E  D  LA H++ L+    ++ QA
Sbjct: 620 IESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQ--SEEQA 677

Query: 550 VEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPIT 609
            E  +D+A LK +IAY      PRLS EA++ L   Y+ MR       +    R  +   
Sbjct: 678 EEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMR-------KIGSSRGMVSAY 730

Query: 610 VRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAA---------LSGTLSGV 660
            RQLE+++R+AEA +K++L       DVEEA RL + +   +A         +S   +G+
Sbjct: 731 PRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGM 790

Query: 661 EGFTSQEDQEMLSRIEK 677
              + +  +E+   ++K
Sbjct: 791 SATSRKRKEELAEALKK 807


>gi|33356547 minichromosome maintenance complex component 2 [Homo
           sapiens]
          Length = 904

 Score =  323 bits (828), Expect = 4e-88
 Identities = 235/741 (31%), Positives = 373/741 (50%), Gaps = 74/741 (9%)

Query: 30  QLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLY 89
           ++  RFK FLR +        F  +  D  K +       + V  EDLA+ +  LA +L 
Sbjct: 194 EIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRES----LVVNYEDLAAREHVLAYFLP 249

Query: 90  KQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHLV 149
           + PAE LQ+ +EAA EV   V    P  + +   I V +        +RSL+   ++ L+
Sbjct: 250 EAPAELLQIFDEAALEV---VLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLI 306

Query: 150 KIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCP- 208
           +  G++ + + V  + + +   C  C   L         E    P  C       P+C  
Sbjct: 307 RTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQE--VKPGSC-------PECQS 357

Query: 209 LDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGI 268
             P+ +  ++    ++Q +++QE P  V  G +PR         L D   PG+ + + GI
Sbjct: 358 AGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGI 417

Query: 269 YSIKKFG-LTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFRRLAA 327
           Y     G L T+ G       I ++++             +   G ++ ++ +    L+ 
Sbjct: 418 YHNNYDGSLNTANGFPVFATVILANHV--------AKKDNKVAVGELTDEDVKMITSLSK 469

Query: 328 LPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTR-RGDINLLMLGDPGTA 386
              + E I  SIAPSI+G  D+K+ +A  LFGG  K  P G  + RGDIN+L+ GDPGTA
Sbjct: 470 DQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKN-PGGKHKVRGDINVLLCGDPGTA 528

Query: 387 KSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDE 446
           KSQ LK++EK S   ++T+G+G+SA GLTA V R P SR + +E GA+VLAD GV  IDE
Sbjct: 529 KSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDE 588

Query: 447 FDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDET-KGEDNID 505
           FDKM + DR +IHEAMEQQ+ISI+KAGI T+L +RC+V+AAAN + GR+D +    +N+D
Sbjct: 589 FDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVD 648

Query: 506 FMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHV-------------------SALTQ 546
               I+SRFD++ +V+D  +  +D MLA+ V+  HV                    A+  
Sbjct: 649 LTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPN 708

Query: 547 TQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSI 606
           T  VE  +    LKK+I Y + +  P+L+    +K+   Y  +R       ++S    SI
Sbjct: 709 TYGVE-PLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLR-------KESMATGSI 760

Query: 607 PITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDA-------ALSGTLSG 659
           PITVR +E+++R+AEA +++ L+ +  E DV  A+R+   S +D        ++  T + 
Sbjct: 761 PITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFAR 820

Query: 660 VEGFTSQEDQEMLSRIEKQL------KRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQ 713
              F  +++ E+L  I KQL       +R   G+Q     + +     K  +  IH +  
Sbjct: 821 YLSF-RRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSA 879

Query: 714 L----MLRRGEIQHRMQRKVL 730
                + R  +  H ++RK++
Sbjct: 880 FYDSELFRMNKFSHDLKRKMI 900


>gi|33469968 minichromosome maintenance complex component 7 isoform
           1 [Homo sapiens]
          Length = 719

 Score =  310 bits (793), Expect = 4e-84
 Identities = 207/654 (31%), Positives = 347/654 (53%), Gaps = 61/654 (9%)

Query: 32  QRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQ 91
           + + K+FL+++    +     FKY ++L R  +  +  + V+++D+A  D +L D + + 
Sbjct: 10  KEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICEN 69

Query: 92  PAEHLQLLEEAAKEVADEVTRPRPSGEEVLQ---DIQVMLK------------------- 129
              + +L  +A +E+  +        ++VL    + ++M++                   
Sbjct: 70  ARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQNQYPAE 129

Query: 130 ------------SDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRN 177
                       S   P  IR +++D +  LV + GI+   S V+ K    +  C  C  
Sbjct: 130 LMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGA 189

Query: 178 TLTNIAMRPGLEGYAL--PRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDA 235
                   P      +   ++C T+++G         ++     + + FQ +K+QE  D 
Sbjct: 190 ETYQPIQSPTFMPLIMCPSQECQTNRSG------GRLYLQTRGSRFIKFQEMKMQEHSDQ 243

Query: 236 VPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIR 295
           VP G +PR + +  +        PG+ V++ GI+      +  +  R  V   +  +Y+ 
Sbjct: 244 VPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIF----LPILRTGFRQVVQGLLSETYLE 299

Query: 296 VLGI-QVDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIA 354
              I +++      S AG ++    EE R++A   + YE ++ SIAP I+G  D+KKA+ 
Sbjct: 300 AHRIVKMNKSEDDESGAGELT---REELRQIAE-EDFYEKLAASIAPEIYGHEDVKKALL 355

Query: 355 CLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGL 414
            LL GG  +  P G+  RG+IN+ ++GDPG AKSQLL ++++ +P   YT+G+GSS  GL
Sbjct: 356 LLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGL 414

Query: 415 TASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 474
           TA+V+RD  S    +EGGA+VLAD GV CIDEFDKM E DR AIHE MEQQTISIAKAGI
Sbjct: 415 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGI 474

Query: 475 TTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLA 533
            TTLN+RCS+LAAAN  +GR++  +  E NI     +LSRFD++++++D  + + D+ LA
Sbjct: 475 LTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 534

Query: 534 KHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGA 593
           +H+  +H  +       E  +D+  ++++IA CR K  P +    A+ +   Y+ MR  A
Sbjct: 535 QHITYVHQHSRQPPSQFE-PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREA 592

Query: 594 RQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVS 647
               +D+   S+     R L AI+R++ AL+++++     + DV EA+RL ++S
Sbjct: 593 -WASKDATYTSA-----RTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 640


>gi|7427519 minichromosome maintenance complex component 6 [Homo
           sapiens]
          Length = 821

 Score =  291 bits (744), Expect = 2e-78
 Identities = 201/657 (30%), Positives = 333/657 (50%), Gaps = 65/657 (9%)

Query: 32  QRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQ 91
           Q+ F +FL +++       +     + ++   N     + V   DL  F++ L+  + ++
Sbjct: 27  QKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNT----LVVSFVDLEQFNQQLSTTIQEE 82

Query: 92  PAEHLQLLEEAAKE-VADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHLVK 150
                  L  A K  V D    P      + +D  V  +   +   IR L S  +  L +
Sbjct: 83  FYRVYPYLCRALKTFVKDRKEIP------LAKDFYVAFQDLPTRHKIRELTSSRIGLLTR 136

Query: 151 IPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCPLD 210
           I G ++    V  +    +  C  C+  + ++  +     Y  P  C       P C   
Sbjct: 137 ISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQ---FKYTQPNICRN-----PVCANR 188

Query: 211 PYFIMP-DKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRV----TI 265
             F++  +K + VDFQ +++QE    +P G +PR +++       +    G++     T+
Sbjct: 189 RRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTL 248

Query: 266 MGIYSIKKFGLTTSR-----------GRDRVGV-GIRSSYIRVLGIQV------------ 301
           + +  + K     +R           G +  G+ G+R+  +R L  ++            
Sbjct: 249 IVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNP 308

Query: 302 --------DTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAI 353
                   D + +  S    ++ +E E+   ++   N+Y  +  S+ P+I G  ++K+ +
Sbjct: 309 RFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGV 368

Query: 354 ACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAG 413
             +LFGG  K   +G + RGDIN+ ++GDP TAKSQ LK VE+ SP  VYTSGK SSAAG
Sbjct: 369 LLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAG 428

Query: 414 LTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAG 473
           LTA+V+RD  S  F++E GA++LAD GV CIDEFDKM   D+VAIHEAMEQQTISI KAG
Sbjct: 429 LTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAG 488

Query: 474 ITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVML 532
           +  TLN+R S+LAAAN + G +D +K  + NI+    I+SRFD+ FI+ DE NE  D  +
Sbjct: 489 VKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAI 548

Query: 533 AKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSG 592
           A+ ++ LH       ++++    L  +++++ + R +  P++S E+ + +  +Y      
Sbjct: 549 ARRIVDLHSRI---EESIDRVYSLDDIRRYLLFAR-QFKPKISKESEDFIVEQY----KH 600

Query: 593 ARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTL 649
            RQ +     +SS  ITVRQLE+++R++EA+++M          V+EA RL   S +
Sbjct: 601 LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSII 657


>gi|6631095 minichromosome maintenance complex component 3 [Homo
           sapiens]
          Length = 808

 Score =  289 bits (739), Expect = 7e-78
 Identities = 216/687 (31%), Positives = 333/687 (48%), Gaps = 87/687 (12%)

Query: 55  YRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPR 114
           Y+ +++   +  +Y + V + DL   +E  A+ L     E L   + A K+    +    
Sbjct: 32  YQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATY 91

Query: 115 PSGEEVLQDIQVMLKSDASPSSI--RSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQC 172
               E   +  V L+       +  R+L S  +S +V + GI+   S VR K  R    C
Sbjct: 92  AKQYE---EFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYC 148

Query: 173 RSCRNT-------LTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQ 225
            + + T       LT +   P    Y  P K   +     +  L  Y          D Q
Sbjct: 149 PATKKTIERRYSDLTTLVAFPSSSVY--PTKDEENNPLETEYGLSVY---------KDHQ 197

Query: 226 TLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRV 285
           T+ +QE+P+  P G++PR + +  D  L DK  PG+RV ++G Y      L   +G    
Sbjct: 198 TITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRC----LPGKKG---- 249

Query: 286 GVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFRRLAAL--PNVYEVISKSIAPSI 343
             G  S   R + I  +     +    + S ++  + ++ +     ++++ ++KS+APSI
Sbjct: 250 --GYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSI 307

Query: 344 FGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVY 403
            G   +KKAI CLL GG  + L +G   RGDIN+L++GDP  AKSQLL++V   +P  + 
Sbjct: 308 HGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIP 367

Query: 404 TSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAME 463
           T+G+GSS  GLTA+V  D  +    +E GAMVLAD GVVCIDEFDKM + DR AIHE ME
Sbjct: 368 TTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVME 427

Query: 464 QQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGE-DNIDFMPTILSRFDMIFIVKD 522
           Q  ++IAKAGI   LN+RCSVLAAAN V+GR+D+ K   +NI    ++LSRFD++FI+ D
Sbjct: 428 QGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLD 487

Query: 523 EHNEERDVMLAKHVITLH---------VSALTQTQAV----------------------- 550
           + + E+D  ++ HV+ +H           A+    AV                       
Sbjct: 488 QMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEK 547

Query: 551 ------------EGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHER 598
                       E  +  A +KK+I   ++   P L+ E+A  +   Y  +RS   Q   
Sbjct: 548 HDNLLHGTKKKKEKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRS---QDSM 603

Query: 599 DSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAAL---SG 655
            SD   + P+T R LE ++R+A A +K ++       D EEA+ L Q +     L     
Sbjct: 604 SSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKK 663

Query: 656 TLSGVEGFTSQEDQEMLSRIEKQLKRR 682
                E  +  ED+E  S+ +++ KR+
Sbjct: 664 RKKRSEDESETEDEEEKSQEDQEQKRK 690


>gi|33469922 minichromosome maintenance complex component 7 isoform
           2 [Homo sapiens]
          Length = 543

 Score =  282 bits (721), Expect = 9e-76
 Identities = 172/455 (37%), Positives = 271/455 (59%), Gaps = 25/455 (5%)

Query: 195 RKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLC 254
           ++C T+++G         ++     + + FQ +K+QE  D VP G +PR + +  +    
Sbjct: 33  QECQTNRSG------GRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENT 86

Query: 255 DKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGI-QVDTDGSGRSFAGA 313
               PG+ V++ GI+      +  +  R  V   +  +Y+    I +++      S AG 
Sbjct: 87  RIAQPGDHVSVTGIF----LPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGE 142

Query: 314 VSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRG 373
           ++    EE R++A   + YE ++ SIAP I+G  D+KKA+  LL GG  +  P G+  RG
Sbjct: 143 LT---REELRQIAE-EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRG 197

Query: 374 DINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGA 433
           +IN+ ++GDPG AKSQLL ++++ +P   YT+G+GSS  GLTA+V+RD  S    +EGGA
Sbjct: 198 NINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGA 257

Query: 434 MVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFG 493
           +VLAD GV CIDEFDKM E DR AIHE MEQQTISIAKAGI TTLN+RCS+LAAAN  +G
Sbjct: 258 LVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 317

Query: 494 RWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEG 552
           R++  +  E NI     +LSRFD++++++D  + + D+ LA+H+  +H  +       E 
Sbjct: 318 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFE- 376

Query: 553 EIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQ 612
            +D+  ++++IA CR K  P +    A+ +   Y+ MR  A    +D+   S+     R 
Sbjct: 377 PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREA-WASKDATYTSA-----RT 429

Query: 613 LEAIVRIAEALSKMKLQPFATEADVEEALRLFQVS 647
           L AI+R++ AL+++++     + DV EA+RL ++S
Sbjct: 430 LLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 464


>gi|33469924 minichromosome maintenance complex component 8 isoform
           2 [Homo sapiens]
          Length = 824

 Score =  247 bits (631), Expect = 2e-65
 Identities = 178/557 (31%), Positives = 289/557 (51%), Gaps = 70/557 (12%)

Query: 135 SSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEG-YAL 193
           + +++++++     + + G ++  S ++   T+++  C +C      I   P  +G Y+L
Sbjct: 205 TQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGE----IQSFPLPDGKYSL 260

Query: 194 PRKCNTDQAGRPKCPLDPYFIMPDKCKCV--DFQTLKLQEL--PDAVPHGEMPRHMQLYC 249
           P KC       P C    +  +      V  D+Q++K+QEL   D    G +PR ++   
Sbjct: 261 PTKCPV-----PVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECEL 315

Query: 250 DRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRS 309
              L D  VPG+ VTI GI  +       S    + G   +SS           DG    
Sbjct: 316 VHDLVDSCVPGDTVTITGIVKVSNAEEANSISNSK-GQKTKSS----------EDGCKHG 364

Query: 310 FAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDG- 368
                S ++    + + A  N++++I  S+ P IFG   +K  +A  LFGGS+K   D  
Sbjct: 365 MLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKN 424

Query: 369 -LTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNF 427
            +  RGD ++L++GDPG  KSQ+L+     +P GVY  G  ++ +GLT ++ +D SS +F
Sbjct: 425 RIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDF 484

Query: 428 IMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAA 487
            +E GA+VL D G+  IDEFDKM    + A+ EAMEQQ+IS+AKAG+  +L +R S++AA
Sbjct: 485 ALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAA 543

Query: 488 ANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH------ 540
           AN V G +++ K   +N+     +LSRFD++FI+ D  NE  D +L++HVI +       
Sbjct: 544 ANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRT 603

Query: 541 VSALT------------------------QTQAVEGE----IDLAKLKKFIAYCRVKCGP 572
           +S+ T                        + + V GE    I    L+K+I Y R    P
Sbjct: 604 ISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYP 663

Query: 573 RLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFA 632
           RLS EAA  L++ Y+ +R       + S R +S PIT RQLE+++R+ EA ++++L+  A
Sbjct: 664 RLSTEAARVLQDFYLELR-------KQSQRLNSSPITTRQLESLIRLTEARARLELREEA 716

Query: 633 TEADVEEALRLFQVSTL 649
           T+ D E+ + + + S L
Sbjct: 717 TKEDAEDIVEIMKYSML 733


>gi|19923727 minichromosome maintenance complex component 8 isoform
           1 [Homo sapiens]
          Length = 840

 Score =  245 bits (625), Expect = 1e-64
 Identities = 178/565 (31%), Positives = 291/565 (51%), Gaps = 70/565 (12%)

Query: 135 SSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEG-YAL 193
           + +++++++     + + G ++  S ++   T+++  C +C      I   P  +G Y+L
Sbjct: 205 TQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGE----IQSFPLPDGKYSL 260

Query: 194 PRKCNTDQAGRPKCPLDPYFIMPDKCKCV--DFQTLKLQEL--PDAVPHGEMPRHMQLYC 249
           P KC       P C    +  +      V  D+Q++K+QEL   D    G +PR ++   
Sbjct: 261 PTKCPV-----PVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECEL 315

Query: 250 DRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGI--------QV 301
              L D  VPG+ VTI GI  +      +    D+    +   YI    I        + 
Sbjct: 316 VHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLL---YIEANSISNSKGQKTKS 372

Query: 302 DTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGS 361
             DG         S ++    + + A  N++++I  S+ P IFG   +K  +A  LFGGS
Sbjct: 373 SEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGS 432

Query: 362 RKRLPDG--LTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVM 419
           +K   D   +  RGD ++L++GDPG  KSQ+L+     +P GVY  G  ++ +GLT ++ 
Sbjct: 433 QKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLS 492

Query: 420 RDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLN 479
           +D SS +F +E GA+VL D G+  IDEFDKM    + A+ EAMEQQ+IS+AKAG+  +L 
Sbjct: 493 KDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLP 551

Query: 480 SRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVIT 538
           +R S++AAAN V G +++ K   +N+     +LSRFD++FI+ D  NE  D +L++HVI 
Sbjct: 552 ARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIA 611

Query: 539 LH------VSALT------------------------QTQAVEGE----IDLAKLKKFIA 564
           +       +S+ T                        + + V GE    I    L+K+I 
Sbjct: 612 IRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIG 671

Query: 565 YCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALS 624
           Y R    PRLS EAA  L++ Y+ +R       + S R +S PIT RQLE+++R+ EA +
Sbjct: 672 YARQYVYPRLSTEAARVLQDFYLELR-------KQSQRLNSSPITTRQLESLIRLTEARA 724

Query: 625 KMKLQPFATEADVEEALRLFQVSTL 649
           +++L+  AT+ D E+ + + + S L
Sbjct: 725 RLELREEATKEDAEDIVEIMKYSML 749


>gi|23397546 minichromosome maintenance complex component 9 [Homo
           sapiens]
          Length = 391

 Score =  107 bits (267), Expect = 4e-23
 Identities = 93/365 (25%), Positives = 165/365 (45%), Gaps = 17/365 (4%)

Query: 59  LKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRP--RPS 116
           LK       Y + V    L   + ++ +Y    P+E L + + A +  A  + +   +P 
Sbjct: 29  LKERDEDAHYPVVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRRSALTILQSLSQPE 88

Query: 117 GEEVLQDIQVMLKS-DASPSSIRSL--KSDMMSHLVKIPGIIIAASAVRAKATRISIQCR 173
              + Q++   +      P  +R    K+  + H + + G +I  S V+         C 
Sbjct: 89  AVSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCN 148

Query: 174 SCRNTLTNIAMRPGLEGYALPRKC---NTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQ 230
            C++     A       +  P  C    +  + +  C L      P +C+  D+Q +K+Q
Sbjct: 149 KCKHVFVIKADFEQYYTFCRPSSCPSLESCDSSKFTC-LSGLSSSPTRCR--DYQEIKIQ 205

Query: 231 ELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIR 290
           E    +  G +PR M++  +  L D    G+ +TI GI  ++++       R  V + ++
Sbjct: 206 EQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIV-MQRWKPFQQDVRCEVEIVLK 264

Query: 291 SSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFRRLAALPNV-YEVISKSIAPSIFGGTDM 349
           ++YI+V   Q     SG      V  + E+ +    + P     VI  S+ P +FG   +
Sbjct: 265 ANYIQVNNEQ----SSGIIMDEEVQKEFEDFWEYYKSDPFAGRNVILASLCPQVFGMYLV 320

Query: 350 KKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGS 409
           K A+A +L GG ++    G   RG+ +LL++GDPGT KSQ LK+  K +P  V T+G GS
Sbjct: 321 KLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGS 380

Query: 410 SAAGL 414
           ++AG+
Sbjct: 381 TSAGI 385


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 34.7 bits (78), Expect = 0.33
 Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 16/56 (28%)

Query: 186 PGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKC----VDFQTLKLQELPDAVP 237
           PG E Y L  +CN+D             + P KC+C    V+  +LKL ++P+ +P
Sbjct: 496 PGTEDYQLNSECNSD------------VVCPHKCRCEANVVECSSLKLTKIPERIP 539


>gi|23957690 component of oligomeric golgi complex 7 [Homo sapiens]
          Length = 770

 Score = 34.3 bits (77), Expect = 0.42
 Identities = 28/127 (22%), Positives = 61/127 (48%), Gaps = 7/127 (5%)

Query: 577 EAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFAT-EA 635
           + A  LK + I+++   ++ E+D+ +   + + + Q+++ +++A A S  +   ++T  A
Sbjct: 78  QEASFLKEQMILVKEDIKKFEQDTSQSMQVLVEIDQVKSRMQLA-AESLQEADKWSTLSA 136

Query: 636 DVEEALRLFQVSTLDAALSGTLSGVEGFTSQED-QEMLSRIEKQLKRRFAIGSQVSEHSI 694
           D+EE  +   ++ + A L+G  + +       D  E    +E    R  A+ S      I
Sbjct: 137 DIEETFKTQDIAVISAKLTGMQNSLMMLVDTPDYSEKCVHLEALKNRLEALASP----QI 192

Query: 695 IKDFTKQ 701
           +  FT Q
Sbjct: 193 VAAFTSQ 199


>gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens]
          Length = 1621

 Score = 33.5 bits (75), Expect = 0.72
 Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 13/88 (14%)

Query: 75   EDLASFDEDLADYLYKQPAEHL-----------QLLEEAAKEVADEVTRPRPSGEEVLQD 123
            EDLA+F E+L D +  Q  E +           ++ +   K++  E T P P G  ++ +
Sbjct: 1182 EDLAAFVEEL-DKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPE 1240

Query: 124  IQVMLKSDASPSSIRSLKSDMMSHLVKI 151
            I  M K+DAS   ++  K D+ +  VK+
Sbjct: 1241 ITAM-KADASKKLLKKKKGDLDTAAVKV 1267


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score = 33.1 bits (74), Expect = 0.95
 Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 2/93 (2%)

Query: 601  DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV 660
            DR+S++ +  R+ E I   AE   K+K+    +  D      L +  T +  L G     
Sbjct: 3387 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3446

Query: 661  EGF--TSQEDQEMLSRIEKQLKRRFAIGSQVSE 691
            + F  T +   E L+ IEK+L     IG+Q S+
Sbjct: 3447 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3479


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score = 33.1 bits (74), Expect = 0.95
 Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 2/93 (2%)

Query: 601  DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV 660
            DR+S++ +  R+ E I   AE   K+K+    +  D      L +  T +  L G     
Sbjct: 3398 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3457

Query: 661  EGF--TSQEDQEMLSRIEKQLKRRFAIGSQVSE 691
            + F  T +   E L+ IEK+L     IG+Q S+
Sbjct: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3490


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score = 33.1 bits (74), Expect = 0.95
 Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 2/93 (2%)

Query: 601  DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV 660
            DR+S++ +  R+ E I   AE   K+K+    +  D      L +  T +  L G     
Sbjct: 3536 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3595

Query: 661  EGF--TSQEDQEMLSRIEKQLKRRFAIGSQVSE 691
            + F  T +   E L+ IEK+L     IG+Q S+
Sbjct: 3596 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3628


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score = 33.1 bits (74), Expect = 0.95
 Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 2/93 (2%)

Query: 601  DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV 660
            DR+S++ +  R+ E I   AE   K+K+    +  D      L +  T +  L G     
Sbjct: 3358 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3417

Query: 661  EGF--TSQEDQEMLSRIEKQLKRRFAIGSQVSE 691
            + F  T +   E L+ IEK+L     IG+Q S+
Sbjct: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3450


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score = 33.1 bits (74), Expect = 0.95
 Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 2/93 (2%)

Query: 601  DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV 660
            DR+S++ +  R+ E I   AE   K+K+    +  D      L +  T +  L G     
Sbjct: 3032 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3091

Query: 661  EGF--TSQEDQEMLSRIEKQLKRRFAIGSQVSE 691
            + F  T +   E L+ IEK+L     IG+Q S+
Sbjct: 3092 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3124


>gi|51093861 caspase recruitment domain protein 10 [Homo sapiens]
          Length = 1032

 Score = 32.7 bits (73), Expect = 1.2
 Identities = 41/175 (23%), Positives = 71/175 (40%), Gaps = 16/175 (9%)

Query: 25  QARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDE---LKRHYNLGEYWIEVEMEDLASFD 81
           +ARKSQLQR  +   R   +  +R G   + RD+    +R   L E W    +E L   D
Sbjct: 145 EARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKD 204

Query: 82  EDLADYLYKQPAEHLQLLEE------AAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPS 135
           E+     Y       QL EE       ++++   V + +     + ++  ++ ++   P 
Sbjct: 205 EN-----YMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPP 259

Query: 136 SIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEG 190
                + +      K P  +   S +RA+  R++   R  +  L   A RPG  G
Sbjct: 260 GAEEKEKEKEKE--KEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPG 312


>gi|54792146 tripartite motif-containing 47 [Homo sapiens]
          Length = 638

 Score = 32.3 bits (72), Expect = 1.6
 Identities = 33/132 (25%), Positives = 56/132 (42%), Gaps = 2/132 (1%)

Query: 559 LKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVR 618
           L+    YCR +      A AA++ +   ++     R  +     +    +  R  E    
Sbjct: 186 LRPLERYCRAERVCLCEACAAQEHRGHELVPLEQERALQEAEQSKVLSAVEDRMDELGAG 245

Query: 619 IAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGVEGFTSQEDQEMLSRIEKQ 678
           IA++   + L   A  A+ E   RLF  +   AAL G  + V GF  + +  ML R +  
Sbjct: 246 IAQSRRTVALIKSAAVAERERVSRLFADAA--AALQGFQTQVLGFIEEGEAAMLGRSQGD 303

Query: 679 LKRRFAIGSQVS 690
           L+R+    S++S
Sbjct: 304 LRRQEEQRSRLS 315


>gi|13569840 MACRO domain containing 1 [Homo sapiens]
          Length = 325

 Score = 32.0 bits (71), Expect = 2.1
 Identities = 35/135 (25%), Positives = 61/135 (45%), Gaps = 18/135 (13%)

Query: 73  EMEDLASFDEDLADYLYKQPAEH-----------LQLLEEAAKEVADEVTRPRPSGEEVL 121
           + ++  SF + L+D   KQ  EH           +   +E AK VA +V  PR   ++ L
Sbjct: 94  DWKEAKSFLKGLSD---KQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQL 150

Query: 122 QDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTN 181
            +   +L+SD +   + ++ +   S L+   G  +     RA    ++ +CR+ ++  T 
Sbjct: 151 NEKISLLRSDITKLEVDAIVNAANSSLLGGGG--VDGCIHRAAGPLLTDECRTLQSCKTG 208

Query: 182 IAMRPGLEGYALPRK 196
            A   G  GY LP K
Sbjct: 209 KAKITG--GYRLPAK 221


>gi|31563531 stromal antigen 2 isoform b [Homo sapiens]
          Length = 1231

 Score = 32.0 bits (71), Expect = 2.1
 Identities = 40/189 (21%), Positives = 79/189 (41%), Gaps = 20/189 (10%)

Query: 1    MSGFDDPGIFYSDSFGGDAQADEGQARKS---QLQRRFKEFLRQYRVGTDRTGFTFKYRD 57
            M  ++D G    ++     Q D+ Q  K+    LQ+ F E +++     DR+  TF    
Sbjct: 890  MKYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIK 949

Query: 58   ELKRHYNLGEYWIEVE-MEDLASFDEDLADYLYKQP-----------AEHLQLLEEAAKE 105
            EL R + L     +++  E +A   +D  ++ +K+P              L +L E + +
Sbjct: 950  ELARRFALTFGLDQLKTREAIAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSK 1009

Query: 106  VADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMS-----HLVKIPGIIIAASA 160
            +  +  R      E     Q+ L+ +     + S ++ +++      +  I GI    S 
Sbjct: 1010 LLRQDKRTVYVYLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVISGISSRGST 1069

Query: 161  VRAKATRIS 169
            VR+K ++ S
Sbjct: 1070 VRSKKSKPS 1078


>gi|112789530 stromal antigen 2 isoform b [Homo sapiens]
          Length = 1231

 Score = 32.0 bits (71), Expect = 2.1
 Identities = 40/189 (21%), Positives = 79/189 (41%), Gaps = 20/189 (10%)

Query: 1    MSGFDDPGIFYSDSFGGDAQADEGQARKS---QLQRRFKEFLRQYRVGTDRTGFTFKYRD 57
            M  ++D G    ++     Q D+ Q  K+    LQ+ F E +++     DR+  TF    
Sbjct: 890  MKYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIK 949

Query: 58   ELKRHYNLGEYWIEVE-MEDLASFDEDLADYLYKQP-----------AEHLQLLEEAAKE 105
            EL R + L     +++  E +A   +D  ++ +K+P              L +L E + +
Sbjct: 950  ELARRFALTFGLDQLKTREAIAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSK 1009

Query: 106  VADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMS-----HLVKIPGIIIAASA 160
            +  +  R      E     Q+ L+ +     + S ++ +++      +  I GI    S 
Sbjct: 1010 LLRQDKRTVYVYLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVISGISSRGST 1069

Query: 161  VRAKATRIS 169
            VR+K ++ S
Sbjct: 1070 VRSKKSKPS 1078


>gi|112789528 stromal antigen 2 isoform a [Homo sapiens]
          Length = 1268

 Score = 32.0 bits (71), Expect = 2.1
 Identities = 40/189 (21%), Positives = 79/189 (41%), Gaps = 20/189 (10%)

Query: 1    MSGFDDPGIFYSDSFGGDAQADEGQARKS---QLQRRFKEFLRQYRVGTDRTGFTFKYRD 57
            M  ++D G    ++     Q D+ Q  K+    LQ+ F E +++     DR+  TF    
Sbjct: 890  MKYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIK 949

Query: 58   ELKRHYNLGEYWIEVE-MEDLASFDEDLADYLYKQP-----------AEHLQLLEEAAKE 105
            EL R + L     +++  E +A   +D  ++ +K+P              L +L E + +
Sbjct: 950  ELARRFALTFGLDQLKTREAIAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSK 1009

Query: 106  VADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMS-----HLVKIPGIIIAASA 160
            +  +  R      E     Q+ L+ +     + S ++ +++      +  I GI    S 
Sbjct: 1010 LLRQDKRTVYVYLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVISGISSRGST 1069

Query: 161  VRAKATRIS 169
            VR+K ++ S
Sbjct: 1070 VRSKKSKPS 1078


>gi|112789526 stromal antigen 2 isoform a [Homo sapiens]
          Length = 1268

 Score = 32.0 bits (71), Expect = 2.1
 Identities = 40/189 (21%), Positives = 79/189 (41%), Gaps = 20/189 (10%)

Query: 1    MSGFDDPGIFYSDSFGGDAQADEGQARKS---QLQRRFKEFLRQYRVGTDRTGFTFKYRD 57
            M  ++D G    ++     Q D+ Q  K+    LQ+ F E +++     DR+  TF    
Sbjct: 890  MKYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIK 949

Query: 58   ELKRHYNLGEYWIEVE-MEDLASFDEDLADYLYKQP-----------AEHLQLLEEAAKE 105
            EL R + L     +++  E +A   +D  ++ +K+P              L +L E + +
Sbjct: 950  ELARRFALTFGLDQLKTREAIAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSK 1009

Query: 106  VADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMS-----HLVKIPGIIIAASA 160
            +  +  R      E     Q+ L+ +     + S ++ +++      +  I GI    S 
Sbjct: 1010 LLRQDKRTVYVYLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVISGISSRGST 1069

Query: 161  VRAKATRIS 169
            VR+K ++ S
Sbjct: 1070 VRSKKSKPS 1078


>gi|169234949 CWF19-like 2, cell cycle control [Homo sapiens]
          Length = 894

 Score = 32.0 bits (71), Expect = 2.1
 Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 4/115 (3%)

Query: 94  EHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHL-VKIP 152
           EH  + E+  ++  DEV R  P  +E L+D +          SI  L  D  + L  KI 
Sbjct: 442 EHQHVPEDPREKSQDEVLRDDPPKKEHLRDTKSTFAGSPERESIHILSVDEKNKLGAKII 501

Query: 153 GIIIAASAVRAKATRISIQ-CRSCRNTLTNIAMRPGLEGYALPR--KCNTDQAGR 204
              +  +   A+  ++ ++     + T+T I  + G+E           TDQ+GR
Sbjct: 502 KAEMMGNMELAEQLKVQLEKANKFKETITQIPKKSGVENEDQQEVILVRTDQSGR 556


>gi|111038124 succinate dehydrogenase complex assembly factor 1
           [Homo sapiens]
          Length = 115

 Score = 31.2 bits (69), Expect = 3.6
 Identities = 27/95 (28%), Positives = 38/95 (40%), Gaps = 14/95 (14%)

Query: 26  ARKSQLQRRFKEFLRQY-RVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDL 84
           +R S+LQR+     R   R G  + G   + R E ++H  L               D   
Sbjct: 2   SRHSRLQRQVLSLYRDLLRAGRGKPGAEARVRAEFRQHAGLPRS------------DVLR 49

Query: 85  ADYLYKQPAEHLQLLEEAAKEVADEVTRPR-PSGE 118
            +YLY++    LQLL            RPR P+GE
Sbjct: 50  IEYLYRRGRRQLQLLRSGHATAMGAFVRPRAPTGE 84


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score = 30.8 bits (68), Expect = 4.7
 Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 36/185 (19%)

Query: 377 LLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVL 436
           LL+ G PG  K+ L K V   S    +      SAA LT+          ++ EG  +V 
Sbjct: 346 LLLFGPPGNGKTMLAKAVAAESNATFFNI----SAASLTSK---------YVGEGEKLVR 392

Query: 437 A--------DGGVVCIDEFDKMREDDRVAIHEAMEQQTIS--IAKAGITTTLNSRCSVLA 486
           A           ++ IDE D +  + R   H+A  +      I   G+ +  + R  V+ 
Sbjct: 393 ALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMG 452

Query: 487 AANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQ 546
           A N              +D    +L RF     V    NEE  ++L K+++    S LTQ
Sbjct: 453 ATNR----------PQELD--EAVLRRFIKRVYVSLP-NEETRLLLLKNLLCKQGSPLTQ 499

Query: 547 TQAVE 551
            +  +
Sbjct: 500 KELAQ 504


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score = 30.8 bits (68), Expect = 4.7
 Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 36/185 (19%)

Query: 377 LLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVL 436
           LL+ G PG  K+ L K V   S    +      SAA LT+          ++ EG  +V 
Sbjct: 378 LLLFGPPGNGKTMLAKAVAAESNATFFNI----SAASLTSK---------YVGEGEKLVR 424

Query: 437 A--------DGGVVCIDEFDKMREDDRVAIHEAMEQQTIS--IAKAGITTTLNSRCSVLA 486
           A           ++ IDE D +  + R   H+A  +      I   G+ +  + R  V+ 
Sbjct: 425 ALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMG 484

Query: 487 AANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQ 546
           A N              +D    +L RF     V    NEE  ++L K+++    S LTQ
Sbjct: 485 ATNR----------PQELD--EAVLRRFIKRVYVSLP-NEETRLLLLKNLLCKQGSPLTQ 531

Query: 547 TQAVE 551
            +  +
Sbjct: 532 KELAQ 536


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,169,633
Number of Sequences: 37866
Number of extensions: 1151749
Number of successful extensions: 2836
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 2772
Number of HSP's gapped (non-prelim): 42
length of query: 734
length of database: 18,247,518
effective HSP length: 110
effective length of query: 624
effective length of database: 14,082,258
effective search space: 8787328992
effective search space used: 8787328992
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.