Guide to the Human Genome
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Search of human proteins with 23510393

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
         (506 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]           1031   0.0  
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]           1031   0.0  
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]           989   0.0  
gi|41872673 NIMA-related kinase 1 [Homo sapiens]                      331   8e-91
gi|83627721 NIMA-related kinase 5 [Homo sapiens]                      312   5e-85
gi|148839316 NIMA-related kinase 4 [Homo sapiens]                     257   2e-68
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]           220   2e-57
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]          220   2e-57
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]          220   2e-57
gi|4505373 NIMA-related kinase 2 [Homo sapiens]                       203   3e-52
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                     201   2e-51
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                      188   9e-48
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]           175   1e-43
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]            175   1e-43
gi|19424132 NIMA-related kinase 7 [Homo sapiens]                      171   2e-42
gi|217330634 serine/threonine kinase 36 [Homo sapiens]                160   3e-39
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H...   144   2e-34
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   142   7e-34
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   142   7e-34
gi|126362971 serine/threonine kinase 10 [Homo sapiens]                142   7e-34
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   141   1e-33
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho...   140   2e-33
gi|121114283 polo-like kinase 4 [Homo sapiens]                        140   4e-33
gi|41281453 serine/threonine kinase 2 [Homo sapiens]                  140   4e-33
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   139   5e-33
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   139   6e-33
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   139   6e-33
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 139   8e-33
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   135   9e-32
gi|21359873 polo-like kinase 1 [Homo sapiens]                         133   4e-31

>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
          Length = 506

 Score = 1031 bits (2667), Expect = 0.0
 Identities = 506/506 (100%), Positives = 506/506 (100%)

Query: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
           MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP
Sbjct: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60

Query: 61  NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
           NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK
Sbjct: 61  NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120

Query: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
           KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN
Sbjct: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180

Query: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
           NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240

Query: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 300
           NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI
Sbjct: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 300

Query: 301 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 360
           ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR
Sbjct: 301 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 360

Query: 361 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 420
           RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK
Sbjct: 361 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 420

Query: 421 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 480
           NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD
Sbjct: 421 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 480

Query: 481 FEEEDDNPDWVSELKKRAGWQGLCDR 506
           FEEEDDNPDWVSELKKRAGWQGLCDR
Sbjct: 481 FEEEDDNPDWVSELKKRAGWQGLCDR 506


>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
          Length = 506

 Score = 1031 bits (2667), Expect = 0.0
 Identities = 506/506 (100%), Positives = 506/506 (100%)

Query: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
           MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP
Sbjct: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60

Query: 61  NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
           NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK
Sbjct: 61  NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120

Query: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
           KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN
Sbjct: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180

Query: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
           NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240

Query: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 300
           NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI
Sbjct: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 300

Query: 301 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 360
           ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR
Sbjct: 301 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 360

Query: 361 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 420
           RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK
Sbjct: 361 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 420

Query: 421 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 480
           NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD
Sbjct: 421 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 480

Query: 481 FEEEDDNPDWVSELKKRAGWQGLCDR 506
           FEEEDDNPDWVSELKKRAGWQGLCDR
Sbjct: 481 FEEEDDNPDWVSELKKRAGWQGLCDR 506


>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
          Length = 489

 Score =  989 bits (2557), Expect = 0.0
 Identities = 489/506 (96%), Positives = 489/506 (96%), Gaps = 17/506 (3%)

Query: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
           MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP
Sbjct: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60

Query: 61  NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
           NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK
Sbjct: 61  NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120

Query: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
           KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN
Sbjct: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180

Query: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
           NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240

Query: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 300
           NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKK        
Sbjct: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKK-------- 292

Query: 301 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 360
                    QEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR
Sbjct: 293 ---------QEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 343

Query: 361 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 420
           RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK
Sbjct: 344 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 403

Query: 421 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 480
           NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD
Sbjct: 404 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 463

Query: 481 FEEEDDNPDWVSELKKRAGWQGLCDR 506
           FEEEDDNPDWVSELKKRAGWQGLCDR
Sbjct: 464 FEEEDDNPDWVSELKKRAGWQGLCDR 489


>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
          Length = 1258

 Score =  331 bits (849), Expect = 8e-91
 Identities = 151/273 (55%), Positives = 206/273 (75%), Gaps = 1/273 (0%)

Query: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
           M+ Y+ L+ IGEGSFG+A+LV+     + + +KEI + + S    + SR+E  +LA MKH
Sbjct: 1   MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
           PNIV ++ESFE  G LYIVM+YC+GGDL ++I  QKG LF ED IL+WF Q+CL + H+H
Sbjct: 61  PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120

Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
            +++LHRDIKS+NIFLT++G V+LGDFG AR+L++ +  A T +GTPYY+ PEI EN PY
Sbjct: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180

Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239
           NNKSDIW+LGC+LYELCTLKH F+A S KNL+LK+  G   P+  HYSY+L+ LV Q+FK
Sbjct: 181 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 240

Query: 240 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272
           RNP  RPS  ++L +G +A+ ++K L P++I E
Sbjct: 241 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE 273


>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
          Length = 708

 Score =  312 bits (799), Expect = 5e-85
 Identities = 148/274 (54%), Positives = 200/274 (72%), Gaps = 2/274 (0%)

Query: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKS-FSNTQNSRKEAVLLAKMKH 59
           MD Y V++ IG+G+FG+A L + +S ++   +KEI   K      + S+KE +LL KMKH
Sbjct: 1   MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
           PNIVAF  SF+  G L+IVMEYCDGGDLM++I +Q+G LF ED IL WF Q+ LG+ HIH
Sbjct: 61  PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120

Query: 120 KKRVLHRDIKSKNIFLTQNGKV-KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
            +++LHRDIK++NIFL++NG V KLGDFG AR+L+N M  A T +GTPYY+ PEI +N P
Sbjct: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180

Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
           YNNK+DIWSLGC+LYELCTLKHPF+ N+ + L+LK+CQ   +P+   +S EL  L+ Q+F
Sbjct: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240

Query: 239 KRNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272
           + +P  RPS  ++L R  +  L+ K L PE+I E
Sbjct: 241 QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQE 274


>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
          Length = 841

 Score =  257 bits (656), Expect = 2e-68
 Identities = 121/310 (39%), Positives = 193/310 (62%), Gaps = 13/310 (4%)

Query: 4   YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNS-RKEAVLLAKMKHPNI 62
           Y  LR++G+GS+G   LV+H    + + +K++ L  + S  + +  +EA LL+++KHPNI
Sbjct: 6   YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65

Query: 63  VAFKESFEA-EGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
           V +KES+E  +G LYIVM +C+GGDL +K+K+QKG+L PE+ ++ WF Q+ + + ++H+K
Sbjct: 66  VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125

Query: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNN 181
            +LHRD+K++N+FLT+   +K+GD G AR+L N    A T +GTPYY+ PE++ N PYN 
Sbjct: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185

Query: 182 KSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRN 241
           KSD+W+LGC +YE+ TLKH F A    +L+ ++ +G + P+P  YS EL  L++ M  + 
Sbjct: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKR 245

Query: 242 PSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRIA 301
           P  RPS  ++L +  + R +   L              +IK SK+N     +        
Sbjct: 246 PEERPSVRSILRQPYIKRQISFFLE-----------ATKIKTSKNNIKNGDSQSKPFATV 294

Query: 302 LGNEASTVQE 311
           +  EA +  E
Sbjct: 295 VSGEAESNHE 304


>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
          Length = 470

 Score =  220 bits (561), Expect = 2e-57
 Identities = 128/367 (34%), Positives = 210/367 (57%), Gaps = 10/367 (2%)

Query: 4   YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59
           Y++ + +G GSFG   LV  + +    ++  +KEI + +   N T  +  EA LL+K+ H
Sbjct: 29  YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117
           P IV F  SF  + +  I+ EYC+G DL  KI++ K  GK+FPE+ I+ WF Q+ LGV++
Sbjct: 89  PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148

Query: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
           +H++R+LHRD+KSKN+FL +N  +K+GDFG +RLL      A T  GTP+Y+ PE  ++ 
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207

Query: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
            Y+ KSDIWSL CILYE+C + H F  +++ +++LK+ +G    LP  Y  EL  +++ M
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267

Query: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKH--NTPRKKTNP 295
             +NPS RPSA  +L    +   +Q  +     M   ++ L+  K + H  N  +K+ + 
Sbjct: 268 LNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHL 327

Query: 296 SRIRIALGNEASTVQEEEQDRKGSHTDLESIN-ENLVESALRRVNREEKGNKSVHLRKAS 354
             +R     +  T +E  + RK    D ++   + +VE      ++  +  +S + ++ S
Sbjct: 328 QTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLS 387

Query: 355 SPNLHRR 361
              LH +
Sbjct: 388 VDVLHEK 394


>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
          Length = 599

 Score =  220 bits (561), Expect = 2e-57
 Identities = 128/367 (34%), Positives = 210/367 (57%), Gaps = 10/367 (2%)

Query: 4   YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59
           Y++ + +G GSFG   LV  + +    ++  +KEI + +   N T  +  EA LL+K+ H
Sbjct: 29  YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117
           P IV F  SF  + +  I+ EYC+G DL  KI++ K  GK+FPE+ I+ WF Q+ LGV++
Sbjct: 89  PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148

Query: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
           +H++R+LHRD+KSKN+FL +N  +K+GDFG +RLL      A T  GTP+Y+ PE  ++ 
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207

Query: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
            Y+ KSDIWSL CILYE+C + H F  +++ +++LK+ +G    LP  Y  EL  +++ M
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267

Query: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKH--NTPRKKTNP 295
             +NPS RPSA  +L    +   +Q  +     M   ++ L+  K + H  N  +K+ + 
Sbjct: 268 LNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHL 327

Query: 296 SRIRIALGNEASTVQEEEQDRKGSHTDLESIN-ENLVESALRRVNREEKGNKSVHLRKAS 354
             +R     +  T +E  + RK    D ++   + +VE      ++  +  +S + ++ S
Sbjct: 328 QTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLS 387

Query: 355 SPNLHRR 361
              LH +
Sbjct: 388 VDVLHEK 394


>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
          Length = 645

 Score =  220 bits (561), Expect = 2e-57
 Identities = 128/367 (34%), Positives = 210/367 (57%), Gaps = 10/367 (2%)

Query: 4   YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59
           Y++ + +G GSFG   LV  + +    ++  +KEI + +   N T  +  EA LL+K+ H
Sbjct: 29  YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117
           P IV F  SF  + +  I+ EYC+G DL  KI++ K  GK+FPE+ I+ WF Q+ LGV++
Sbjct: 89  PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148

Query: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
           +H++R+LHRD+KSKN+FL +N  +K+GDFG +RLL      A T  GTP+Y+ PE  ++ 
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207

Query: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
            Y+ KSDIWSL CILYE+C + H F  +++ +++LK+ +G    LP  Y  EL  +++ M
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267

Query: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKH--NTPRKKTNP 295
             +NPS RPSA  +L    +   +Q  +     M   ++ L+  K + H  N  +K+ + 
Sbjct: 268 LNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHL 327

Query: 296 SRIRIALGNEASTVQEEEQDRKGSHTDLESIN-ENLVESALRRVNREEKGNKSVHLRKAS 354
             +R     +  T +E  + RK    D ++   + +VE      ++  +  +S + ++ S
Sbjct: 328 QTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLS 387

Query: 355 SPNLHRR 361
              LH +
Sbjct: 388 VDVLHEK 394


>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
          Length = 445

 Score =  203 bits (517), Expect = 3e-52
 Identities = 133/377 (35%), Positives = 191/377 (50%), Gaps = 30/377 (7%)

Query: 2   DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHP 60
           +DY VL  IG GS+GR   ++ +S  ++   KE+     + +  Q    E  LL ++KHP
Sbjct: 6   EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65

Query: 61  NIVAFKESF--EAEGHLYIVMEYCDGGDLMQKIKQ--QKGKLFPEDMILNWFTQMCLGVN 116
           NIV + +         LYIVMEYC+GGDL   I +  ++ +   E+ +L   TQ+ L + 
Sbjct: 66  NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125

Query: 117 HIHKKR-----VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPP 171
             H++      VLHRD+K  N+FL     VKLGDFG AR+L++  +FA T+VGTPYY+ P
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185

Query: 172 EIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQ 231
           E    + YN KSDIWSLGC+LYELC L  PF A S K L  K+ +G    +P  YS EL 
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245

Query: 232 FLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRK 291
            ++ +M      HRPS   +L   ++A         +++ +     LE  +  +   P K
Sbjct: 246 EIITRMLNLKDYHRPSVEEILENPLIA---------DLVADEQRRNLER-RGRQLGEPEK 295

Query: 292 KTNPSRIRIALGNEASTVQEEEQDRKGSHTDLES------INENLVESALRRVNREEKGN 345
             + S +   L  +   +QE E+  K     LE       + E L E  L R     K  
Sbjct: 296 SQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNY 355

Query: 346 KSVHLRK----ASSPNL 358
             +  RK    AS+P L
Sbjct: 356 SLLKERKFLSLASNPEL 372


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score =  201 bits (510), Expect = 2e-51
 Identities = 105/259 (40%), Positives = 162/259 (62%), Gaps = 3/259 (1%)

Query: 4   YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHPNI 62
           Y+ +R++G G+FG A L +    + +   KE+ L + S    +++  E V+LA ++H NI
Sbjct: 52  YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111

Query: 63  VAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKR 122
           +A+   F     L I +EYC+GG+L  KI +QK KLF E+M++ +  Q+   V+ IHK  
Sbjct: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171

Query: 123 VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNK 182
           +LHRDIK+ NIFLT+   +KLGD+G A+ L++  + A T VGTPYY+ PE+ + + YN K
Sbjct: 172 ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFK 231

Query: 183 SDIWSLGCILYELCTLKHPFQANSWKNLILKVCQG--CISPLPSHYSYELQFLVKQMFKR 240
           SDIW++GC+++EL TLK  F A +  NL +K+ QG   +    S YS EL  +V     +
Sbjct: 232 SDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQ 291

Query: 241 NPSHRPSATTLLSRGIVAR 259
           +P  RP+A  LL R ++ +
Sbjct: 292 DPEQRPTADELLDRPLLRK 310


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score =  188 bits (478), Expect = 9e-48
 Identities = 96/261 (36%), Positives = 161/261 (61%), Gaps = 3/261 (1%)

Query: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
           M+ Y  +R++G G+FG   L   ++  ++  +K+I + + +    Q ++ E  +L  + H
Sbjct: 1   MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
           PN++ + E+F  +  L I MEY  GG L + I+++   L  E+ IL++F Q+ L ++H+H
Sbjct: 61  PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120

Query: 120 KKRVLHRDIKSKNIFLTQNGKV-KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
              +LHRD+K++NI L ++  V K+GDFG +++LS+    A T VGTP Y+ PE+ E  P
Sbjct: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKP 179

Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
           YN KSDIW+LGC+LYEL +LK  F+A +   L+LK+  G  +P+   YS EL+ LV  + 
Sbjct: 180 YNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLL 239

Query: 239 KRNPSHRPSATTLLSRGIVAR 259
              P+ RP  + ++++ +  R
Sbjct: 240 SLEPAQRPPLSHIMAQPLCIR 260


>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
          Length = 347

 Score =  175 bits (443), Expect = 1e-43
 Identities = 98/251 (39%), Positives = 140/251 (55%), Gaps = 7/251 (2%)

Query: 3   DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNT--QNSRKEAVLLAKMKHP 60
           D+ + + IG G F            +  A+K++++ +       Q+  KE  LL ++ HP
Sbjct: 78  DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 137

Query: 61  NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
           NI+ + +SF  +  L IV+E  D GDL Q IK  +++ +L PE  +  +F Q+C  V H+
Sbjct: 138 NIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHM 197

Query: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
           H +RV+HRDIK  N+F+T  G VKLGD G  R  S+    A + VGTPYY+ PE      
Sbjct: 198 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENG 257

Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLP-SHYSYELQFLVK 235
           YN KSDIWSLGC+LYE+  L+ PF  +     +L  K+ Q    PLP  HYS +L+ LV 
Sbjct: 258 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVS 317

Query: 236 QMFKRNPSHRP 246
                +P  RP
Sbjct: 318 MCICPDPHQRP 328


>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
          Length = 313

 Score =  175 bits (443), Expect = 1e-43
 Identities = 98/251 (39%), Positives = 140/251 (55%), Gaps = 7/251 (2%)

Query: 3   DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNT--QNSRKEAVLLAKMKHP 60
           D+ + + IG G F            +  A+K++++ +       Q+  KE  LL ++ HP
Sbjct: 44  DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 103

Query: 61  NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
           NI+ + +SF  +  L IV+E  D GDL Q IK  +++ +L PE  +  +F Q+C  V H+
Sbjct: 104 NIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHM 163

Query: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
           H +RV+HRDIK  N+F+T  G VKLGD G  R  S+    A + VGTPYY+ PE      
Sbjct: 164 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENG 223

Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLP-SHYSYELQFLVK 235
           YN KSDIWSLGC+LYE+  L+ PF  +     +L  K+ Q    PLP  HYS +L+ LV 
Sbjct: 224 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVS 283

Query: 236 QMFKRNPSHRP 246
                +P  RP
Sbjct: 284 MCICPDPHQRP 294


>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
          Length = 302

 Score =  171 bits (432), Expect = 2e-42
 Identities = 99/269 (36%), Positives = 144/269 (53%), Gaps = 10/269 (3%)

Query: 3   DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSR--KEAVLLAKMKHP 60
           ++ + + IG G F               A+K++++         +   KE  LL ++ HP
Sbjct: 33  NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92

Query: 61  NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
           N++ +  SF  +  L IV+E  D GDL + IK  +++ +L PE  +  +F Q+C  + H+
Sbjct: 93  NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152

Query: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
           H +RV+HRDIK  N+F+T  G VKLGD G  R  S+    A + VGTPYY+ PE      
Sbjct: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212

Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLPS-HYSYELQFLVK 235
           YN KSDIWSLGC+LYE+  L+ PF  +     +L  K+ Q    PLPS HYS EL+ LV 
Sbjct: 213 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVN 272

Query: 236 QMFKRNPSHRPSATTLLSRGIVARLVQKC 264
                +P  RP  T +     VA+ +  C
Sbjct: 273 MCINPDPEKRPDVTYVYD---VAKRMHAC 298


>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
          Length = 1315

 Score =  160 bits (405), Expect = 3e-39
 Identities = 108/328 (32%), Positives = 175/328 (53%), Gaps = 14/328 (4%)

Query: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEI-RLPKSFSNTQNSRKEAVLLAKMKH 59
           M+ Y VL MIGEGSFGR    + + S Q+ A+K I +L +S    +N ++E  ++  ++H
Sbjct: 1   MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH 60

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
           PNIV   +SFE +  + +V +Y +G +L Q I +  GKL PED +     Q+   + ++H
Sbjct: 61  PNIVHMLDSFETDKEVVVVTDYAEG-ELFQ-ILEDDGKL-PEDQVQAIAAQLVSALYYLH 117

Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
             R+LHRD+K +NI L + G +KL DFG AR +S       +  GTP Y+ PE+ E  PY
Sbjct: 118 SHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPY 177

Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239
           ++ +D+WS+GCILYEL     PF A S   L+  + +  +   PS  S   +  ++ +  
Sbjct: 178 DHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVR-WPSTISPCFKNFLQGLLT 236

Query: 240 RNPSHRPSATTLLSRGIVA---RLVQKCLPPEIIMEYGEEV---LEEIKNSKHNTPRKKT 293
           ++P  R S   LL    +A    ++ +   P++   +   +   L+ +K+ + +    K 
Sbjct: 237 KDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKG 296

Query: 294 NPSRIRIALGNEASTVQEEEQDRKGSHT 321
           N SRI   L      + EE   +K  +T
Sbjct: 297 NQSRI---LTQAYKRMAEEAMQKKHQNT 321


>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
           sapiens]
          Length = 482

 Score =  144 bits (362), Expect = 2e-34
 Identities = 81/248 (32%), Positives = 141/248 (56%), Gaps = 9/248 (3%)

Query: 4   YMVLRMIGEGSFGRALLV---QHESSNQMFAMKEIRLPKSFSN---TQNSRKEAVLLAKM 57
           + +LR++G+G +G+   V   Q  +  +++AMK +R  K   N   T ++R E  +L  +
Sbjct: 67  FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126

Query: 58  KHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNH 117
           KHP IV    +F+  G LY+++E   GG+L   ++++   +F ED    +  ++ L + H
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREG--IFLEDTACFYLAEITLALGH 184

Query: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
           +H + +++RD+K +NI L+  G +KL DFG  +   +  A   T+ GT  Y+ PEI    
Sbjct: 185 LHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRS 244

Query: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
            +N   D WSLG ++Y++ T   PF A + K  + K+ +G ++ LP + + + + LVK+ 
Sbjct: 245 GHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLA-LPPYLTPDARDLVKKF 303

Query: 238 FKRNPSHR 245
            KRNPS R
Sbjct: 304 LKRNPSQR 311


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  142 bits (358), Expect = 7e-34
 Identities = 77/249 (30%), Positives = 143/249 (57%), Gaps = 13/249 (5%)

Query: 4   YMVLRMIGEGSFGRALLVQ---HESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
           + +L+++G+GSFG+  LV+      S  ++AMK ++       +   ++ E  +LA + H
Sbjct: 71  FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 130

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
           P +V    +F+ EG LY+++++  GGDL  ++ ++   +F E+ +  +  ++ LG++H+H
Sbjct: 131 PFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALGLDHLH 188

Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
              +++RD+K +NI L + G +KL DFG ++   +    A ++ GT  Y+ PE+     +
Sbjct: 189 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 248

Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWK---NLILKVCQGCISPLPSHYSYELQFLVKQ 236
           ++ +D WS G +++E+ T   PFQ    K    LILK   G    +P   S E Q L++ 
Sbjct: 249 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG----MPQFLSTEAQSLLRA 304

Query: 237 MFKRNPSHR 245
           +FKRNP++R
Sbjct: 305 LFKRNPANR 313



 Score =  100 bits (248), Expect = 4e-21
 Identities = 74/261 (28%), Positives = 129/261 (49%), Gaps = 16/261 (6%)

Query: 2   DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
           D Y+V   IG GS+       H+++N  +A+K I      S    S +  +LL   +HPN
Sbjct: 425 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVI----DKSKRDPSEEIEILLRYGQHPN 480

Query: 62  IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
           I+  K+ ++   H+Y+V E   GG+L+ KI +Q  K F E         +   V ++H +
Sbjct: 481 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKTVEYLHSQ 538

Query: 122 RVLHRDIKSKNI-FLTQNGK---VKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
            V+HRD+K  NI ++ ++G    +++ DFG A+ L        T   T  +V PE+ +  
Sbjct: 539 GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ 598

Query: 178 PYNNKSDIWSLGCILYELCTLKHPF---QANSWKNLILKVCQGCISPLPSHY---SYELQ 231
            Y+   DIWSLG +LY +     PF    +++ + ++ ++  G  +    ++   S   +
Sbjct: 599 GYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAK 658

Query: 232 FLVKQMFKRNPSHRPSATTLL 252
            LV +M   +P  R +A  +L
Sbjct: 659 DLVSKMLHVDPHQRLTAKQVL 679


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score =  142 bits (358), Expect = 7e-34
 Identities = 77/249 (30%), Positives = 143/249 (57%), Gaps = 13/249 (5%)

Query: 4   YMVLRMIGEGSFGRALLVQ---HESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
           + +L+++G+GSFG+  LV+      S  ++AMK ++       +   ++ E  +LA + H
Sbjct: 62  FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 121

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
           P +V    +F+ EG LY+++++  GGDL  ++ ++   +F E+ +  +  ++ LG++H+H
Sbjct: 122 PFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALGLDHLH 179

Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
              +++RD+K +NI L + G +KL DFG ++   +    A ++ GT  Y+ PE+     +
Sbjct: 180 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 239

Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWK---NLILKVCQGCISPLPSHYSYELQFLVKQ 236
           ++ +D WS G +++E+ T   PFQ    K    LILK   G    +P   S E Q L++ 
Sbjct: 240 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG----MPQFLSTEAQSLLRA 295

Query: 237 MFKRNPSHR 245
           +FKRNP++R
Sbjct: 296 LFKRNPANR 304



 Score =  100 bits (248), Expect = 4e-21
 Identities = 74/261 (28%), Positives = 129/261 (49%), Gaps = 16/261 (6%)

Query: 2   DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
           D Y+V   IG GS+       H+++N  +A+K I      S    S +  +LL   +HPN
Sbjct: 416 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVI----DKSKRDPSEEIEILLRYGQHPN 471

Query: 62  IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
           I+  K+ ++   H+Y+V E   GG+L+ KI +Q  K F E         +   V ++H +
Sbjct: 472 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKTVEYLHSQ 529

Query: 122 RVLHRDIKSKNI-FLTQNGK---VKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
            V+HRD+K  NI ++ ++G    +++ DFG A+ L        T   T  +V PE+ +  
Sbjct: 530 GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ 589

Query: 178 PYNNKSDIWSLGCILYELCTLKHPF---QANSWKNLILKVCQGCISPLPSHY---SYELQ 231
            Y+   DIWSLG +LY +     PF    +++ + ++ ++  G  +    ++   S   +
Sbjct: 590 GYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAK 649

Query: 232 FLVKQMFKRNPSHRPSATTLL 252
            LV +M   +P  R +A  +L
Sbjct: 650 DLVSKMLHVDPHQRLTAKQVL 670


>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
          Length = 968

 Score =  142 bits (358), Expect = 7e-34
 Identities = 85/283 (30%), Positives = 149/283 (52%), Gaps = 9/283 (3%)

Query: 10  IGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESF 69
           +G+G+FG+    +++ +  + A K I   KS    ++   E  +LA   HP IV    ++
Sbjct: 42  LGDGAFGKVYKAKNKETGALAAAKVIET-KSEEELEDYIVEIEILATCDHPYIVKLLGAY 100

Query: 70  EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIK 129
             +G L+I++E+C GG  +  I  +  +   E  I     QM   +N +H KR++HRD+K
Sbjct: 101 YHDGKLWIMIEFCPGG-AVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLK 159

Query: 130 SKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEI-----WENLPYNNKSD 184
           + N+ +T  G ++L DFG +      +    +++GTPY++ PE+      ++ PY+ K+D
Sbjct: 160 AGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKAD 219

Query: 185 IWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPL--PSHYSYELQFLVKQMFKRNP 242
           IWSLG  L E+  ++ P    +   ++LK+ +     L  PS +S E +  +K    +NP
Sbjct: 220 IWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNP 279

Query: 243 SHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSK 285
             RPSA  LL    V+ +       E++ E   EV+EEI++ +
Sbjct: 280 ETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGR 322


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  141 bits (356), Expect = 1e-33
 Identities = 76/249 (30%), Positives = 146/249 (58%), Gaps = 13/249 (5%)

Query: 4   YMVLRMIGEGSFGRALLVQHES---SNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
           + +L+++G+GSFG+  LV+ ++   + Q++AMK ++       +   ++ E  +L ++ H
Sbjct: 73  FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNH 132

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
           P IV    +F+ EG LY+++++  GGD+  ++ ++   LF E+ +  +  ++ L ++H+H
Sbjct: 133 PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEV--LFTEEDVKFYLAELALALDHLH 190

Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
           +  +++RD+K +NI L + G +KL DFG ++   +    A ++ GT  Y+ PE+     +
Sbjct: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 250

Query: 180 NNKSDIWSLGCILYELCTLKHPFQA---NSWKNLILKVCQGCISPLPSHYSYELQFLVKQ 236
           +  +D WS G +++E+ T   PFQ    N   N+ILK   G    +P   S E Q L++ 
Sbjct: 251 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLG----MPQFLSAEAQSLLRM 306

Query: 237 MFKRNPSHR 245
           +FKRNP++R
Sbjct: 307 LFKRNPANR 315



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 69/259 (26%), Positives = 120/259 (46%), Gaps = 16/259 (6%)

Query: 4   YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIV 63
           Y +   IG GS+       H ++N  FA+K I      S    S +  +L+   +HPNI+
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKII----DKSKRDPSEEIEILMRYGQHPNII 481

Query: 64  AFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRV 123
             K+ F+   ++Y+V +   GG+L+ +I +Q  K F E    +    +   V+++H + V
Sbjct: 482 TLKDVFDDGRYVYLVTDLMKGGELLDRILKQ--KCFSEREASDILYVISKTVDYLHCQGV 539

Query: 124 LHRDIKSKNIFLTQNG----KVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
           +HRD+K  NI           +++ DFG A+ L        T   T  +V PE+     Y
Sbjct: 540 VHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGY 599

Query: 180 NNKSDIWSLGCILYELCTLKHPF---QANSWKNLILKVCQGCISPLPSHY---SYELQFL 233
           +   DIWSLG + Y +     PF     ++ + ++L++  G  S    ++   S   + L
Sbjct: 600 DAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDL 659

Query: 234 VKQMFKRNPSHRPSATTLL 252
           +  M   +P  R +A  +L
Sbjct: 660 LSHMLHMDPHQRYTAEQIL 678


>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
           sapiens]
          Length = 525

 Score =  140 bits (354), Expect = 2e-33
 Identities = 77/251 (30%), Positives = 144/251 (57%), Gaps = 9/251 (3%)

Query: 4   YMVLRMIGEGSFGRALLVQH---ESSNQMFAMKEIR---LPKSFSNTQNSRKEAVLLAKM 57
           + +LR++G+G +G+   V+     ++ ++FAMK ++   + ++  +T +++ E  +L ++
Sbjct: 91  FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150

Query: 58  KHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNH 117
           KHP IV    +F+  G LY+++EY  GG+L  +++++   +F ED    +  ++ + + H
Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEISMALGH 208

Query: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
           +H+K +++RD+K +NI L   G VKL DFG  +   +      T+ GT  Y+ PEI    
Sbjct: 209 LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 268

Query: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
            +N   D WSLG ++Y++ T   PF   + K  I K+ + C   LP + + E + L+K++
Sbjct: 269 GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK-CKLNLPPYLTQEARDLLKKL 327

Query: 238 FKRNPSHRPSA 248
            KRN + R  A
Sbjct: 328 LKRNAASRLGA 338


>gi|121114283 polo-like kinase 4 [Homo sapiens]
          Length = 970

 Score =  140 bits (352), Expect = 4e-33
 Identities = 80/261 (30%), Positives = 138/261 (52%), Gaps = 4/261 (1%)

Query: 1   MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSN--TQNSRKEAVLLAKMK 58
           ++D+ V  ++G+GSF      +   +    A+K I     +     Q  + E  +  ++K
Sbjct: 9   IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68

Query: 59  HPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHI 118
           HP+I+     FE   ++Y+V+E C  G++ + +K +  K F E+   ++  Q+  G+ ++
Sbjct: 69  HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRV-KPFSENEARHFMHQIITGMLYL 127

Query: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
           H   +LHRD+   N+ LT+N  +K+ DFG A  L  P     T  GTP Y+ PEI     
Sbjct: 128 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA 187

Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
           +  +SD+WSLGC+ Y L   + PF  ++ KN + KV       +PS  S E + L+ Q+ 
Sbjct: 188 HGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYE-MPSFLSIEAKDLIHQLL 246

Query: 239 KRNPSHRPSATTLLSRGIVAR 259
           +RNP+ R S +++L    ++R
Sbjct: 247 RRNPADRLSLSSVLDHPFMSR 267


>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
          Length = 1235

 Score =  140 bits (352), Expect = 4e-33
 Identities = 99/358 (27%), Positives = 182/358 (50%), Gaps = 20/358 (5%)

Query: 2   DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
           D + ++  +G+G+FG+    Q++ ++ + A K I   KS    ++   E  +LA   HPN
Sbjct: 32  DFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDT-KSEEELEDYMVEIDILASCDHPN 90

Query: 62  IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
           IV   ++F  E +L+I++E+C GG  +  +  +  +   E  I     Q    +N++H  
Sbjct: 91  IVKLLDAFYYENNLWILIEFCAGG-AVDAVMLELERPLTESQIQVVCKQTLDALNYLHDN 149

Query: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEI-----WEN 176
           +++HRD+K+ NI  T +G +KL DFG +   +  +    +++GTPY++ PE+      ++
Sbjct: 150 KIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKD 209

Query: 177 LPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPL--PSHYSYELQFLV 234
            PY+ K+D+WSLG  L E+  ++ P    +   ++LK+ +     L  PS +S   +  +
Sbjct: 210 RPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFL 269

Query: 235 KQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTN 294
           K+  ++N   R + + LL    V     K +  E+I E   EV EE+++ K     ++T 
Sbjct: 270 KKCLEKNVDARWTTSQLLQHPFVTVDSNKPI-RELIAEAKAEVTEEVEDGKEEDEEEETE 328

Query: 295 PSRIRIALGNEAS---TVQEEEQDRKGSHT-DLESINENLVESALRRVNREEKGNKSV 348
            S + I     AS   ++   E+D+   +   LES++E        R N E+K N  +
Sbjct: 329 NS-LPIPASKRASSDLSIASSEEDKLSQNACILESVSEK-----TERSNSEDKLNSKI 380


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score =  139 bits (351), Expect = 5e-33
 Identities = 73/249 (29%), Positives = 142/249 (57%), Gaps = 7/249 (2%)

Query: 4   YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
           + +L+++G+GSFG+  LV+  S +   Q++AMK ++       +   ++ E  +L ++ H
Sbjct: 68  FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNH 127

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
           P IV    +F+ EG LY+++++  GGDL  ++ ++   +F E+ +  +  ++ L ++H+H
Sbjct: 128 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALALDHLH 185

Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
              +++RD+K +NI L + G +KL DFG ++   +    A ++ GT  Y+ PE+     +
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGH 245

Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239
              +D WS G +++E+ T   PFQ    K  +  + +  +  +P   S E Q L++ +FK
Sbjct: 246 TQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLG-MPQFLSPEAQSLLRMLFK 304

Query: 240 RNPSHRPSA 248
           RNP++R  A
Sbjct: 305 RNPANRLGA 313



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 16/261 (6%)

Query: 2   DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
           D Y V   IG GS+       H+++N  FA+K I      S    + +  +LL   +HPN
Sbjct: 420 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKII----DKSKRDPTEEIEILLRYGQHPN 475

Query: 62  IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
           I+  K+ ++   ++Y+V E   GG+L+ KI +QK   F E         +   V ++H +
Sbjct: 476 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQK--FFSEREASAVLFTITKTVEYLHAQ 533

Query: 122 RVLHRDIKSKNI-FLTQNGK---VKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
            V+HRD+K  NI ++ ++G    +++ DFG A+ L        T   T  +V PE+ +  
Sbjct: 534 GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ 593

Query: 178 PYNNKSDIWSLGCILYELCTLKHPF---QANSWKNLILKVCQGCISPLPSHY---SYELQ 231
            Y+   DIWSLG +LY + T   PF     ++ + ++ ++  G  S    ++   S   +
Sbjct: 594 GYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAK 653

Query: 232 FLVKQMFKRNPSHRPSATTLL 252
            LV +M   +P  R +A  +L
Sbjct: 654 DLVSKMLHVDPHQRLTAALVL 674


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score =  139 bits (350), Expect = 6e-33
 Identities = 77/252 (30%), Positives = 142/252 (56%), Gaps = 13/252 (5%)

Query: 4   YMVLRMIGEGSFGRALLVQH---ESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
           + +L+++G+GS+G+  LV+      + Q++AMK ++       +   S+ E  +LA++ H
Sbjct: 67  FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNH 126

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
           P IV    +F+ EG LY+++++  GGDL  ++ ++   +F E+ +  +  ++ L ++H+H
Sbjct: 127 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALALDHLH 184

Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
              +++RD+K +NI L + G +K+ DFG ++   +    A ++ GT  Y+ PE+     +
Sbjct: 185 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGH 244

Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKN---LILKVCQGCISPLPSHYSYELQFLVKQ 236
              +D WS G +++E+ T   PFQ    K    LILK   G    +P   S E Q L++ 
Sbjct: 245 TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLG----MPQFLSGEAQSLLRA 300

Query: 237 MFKRNPSHRPSA 248
           +FKRNP +R  A
Sbjct: 301 LFKRNPCNRLGA 312



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 59/205 (28%), Positives = 100/205 (48%), Gaps = 10/205 (4%)

Query: 2   DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
           D Y +   IG GS+       H++++  +A+K I      S    S +  +LL   +HPN
Sbjct: 421 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKII----DKSKRDPSEEIEILLRYGQHPN 476

Query: 62  IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
           I+  K+ ++    +Y+VME   GG+L+ +I +Q  + F E    +    +   ++++H +
Sbjct: 477 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQ--RYFSEREASDVLCTITKTMDYLHSQ 534

Query: 122 RVLHRDIKSKNIFLTQNG----KVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
            V+HRD+K  NI           +++ DFG A+ L        T   T  +V PE+ +  
Sbjct: 535 GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQ 594

Query: 178 PYNNKSDIWSLGCILYELCTLKHPF 202
            Y+   DIWSLG +LY +     PF
Sbjct: 595 GYDAACDIWSLGILLYTMLAGFTPF 619


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score =  139 bits (350), Expect = 6e-33
 Identities = 77/252 (30%), Positives = 142/252 (56%), Gaps = 13/252 (5%)

Query: 4   YMVLRMIGEGSFGRALLVQH---ESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
           + +L+++G+GS+G+  LV+      + Q++AMK ++       +   S+ E  +LA++ H
Sbjct: 59  FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNH 118

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
           P IV    +F+ EG LY+++++  GGDL  ++ ++   +F E+ +  +  ++ L ++H+H
Sbjct: 119 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALALDHLH 176

Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
              +++RD+K +NI L + G +K+ DFG ++   +    A ++ GT  Y+ PE+     +
Sbjct: 177 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGH 236

Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKN---LILKVCQGCISPLPSHYSYELQFLVKQ 236
              +D WS G +++E+ T   PFQ    K    LILK   G    +P   S E Q L++ 
Sbjct: 237 TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLG----MPQFLSGEAQSLLRA 292

Query: 237 MFKRNPSHRPSA 248
           +FKRNP +R  A
Sbjct: 293 LFKRNPCNRLGA 304



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 59/205 (28%), Positives = 100/205 (48%), Gaps = 10/205 (4%)

Query: 2   DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
           D Y +   IG GS+       H++++  +A+K I      S    S +  +LL   +HPN
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKII----DKSKRDPSEEIEILLRYGQHPN 468

Query: 62  IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
           I+  K+ ++    +Y+VME   GG+L+ +I +Q  + F E    +    +   ++++H +
Sbjct: 469 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQ--RYFSEREASDVLCTITKTMDYLHSQ 526

Query: 122 RVLHRDIKSKNIFLTQNG----KVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
            V+HRD+K  NI           +++ DFG A+ L        T   T  +V PE+ +  
Sbjct: 527 GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQ 586

Query: 178 PYNNKSDIWSLGCILYELCTLKHPF 202
            Y+   DIWSLG +LY +     PF
Sbjct: 587 GYDAACDIWSLGILLYTMLAGFTPF 611


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  139 bits (349), Expect = 8e-33
 Identities = 104/369 (28%), Positives = 171/369 (46%), Gaps = 21/369 (5%)

Query: 6   VLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAF 65
           VL  +GEGS+G      H+ S Q+ A+K++ +    S+ Q   KE  ++ +   P +V +
Sbjct: 29  VLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEISIMQQCDSPYVVKY 85

Query: 66  KESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLH 125
             S+     L+IVMEYC  G +   I+  + K   ED I         G+ ++H  R +H
Sbjct: 86  YGSYFKNTDLWIVMEYCGAGSVSDIIRL-RNKTLIEDEIATILKSTLKGLEYLHFMRKIH 144

Query: 126 RDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDI 185
           RDIK+ NI L   G  KL DFG A  L++ MA   T +GTP+++ PE+ + + YN  +DI
Sbjct: 145 RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 204

Query: 186 WSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPL--PSHYSYELQFLVKQMFKRNPS 243
           WSLG    E+   K P+        I  +          P  +S +    VK+   +NP 
Sbjct: 205 WSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPE 264

Query: 244 HRPSATTLLSR---------GIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTN 294
            R +AT LL            I+  L+ + +  EI  +  EE   E++  + N+   + +
Sbjct: 265 QRATATQLLQHPFIKNAKPVSILRDLITEAM--EIKAKRHEEQQRELEEEEENSDEDELD 322

Query: 295 PSRIRIALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRV---NREEKGNKSVHLR 351
              +         T++      +G+ T +E  N  ++ES L  +   + +E+       R
Sbjct: 323 SHTMVKTSVESVGTMRATSTMSEGAQTMIEH-NSTMLESDLGTMVINSEDEEEEDGTMKR 381

Query: 352 KASSPNLHR 360
            A+SP + R
Sbjct: 382 NATSPQVQR 390


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  135 bits (340), Expect = 9e-32
 Identities = 97/353 (27%), Positives = 167/353 (47%), Gaps = 19/353 (5%)

Query: 6   VLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAF 65
           VL  +GEGS+G      H+ + Q+ A+K++ +    S+ Q   KE  ++ +   P++V +
Sbjct: 32  VLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE---SDLQEIIKEISIMQQCDSPHVVKY 88

Query: 66  KESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLH 125
             S+     L+IVMEYC  G +   I+  + K   ED I         G+ ++H  R +H
Sbjct: 89  YGSYFKNTDLWIVMEYCGAGSVSDIIRL-RNKTLTEDEIATILQSTLKGLEYLHFMRKIH 147

Query: 126 RDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDI 185
           RDIK+ NI L   G  KL DFG A  L++ MA   T +GTP+++ PE+ + + YN  +DI
Sbjct: 148 RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 207

Query: 186 WSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPL--PSHYSYELQFLVKQMFKRNPS 243
           WSLG    E+   K P+        I  +          P  +S      VKQ   ++P 
Sbjct: 208 WSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPE 267

Query: 244 HRPSATTLLSR---------GIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTN 294
            R +AT LL            I+  L+ + +  ++  +  ++  E  ++ + N+   + +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQ-REVDQDDEENSEEDEMD 326

Query: 295 PSRIRIALGNEASTVQEEEQDRKGSHTDLE---SINENLVESALRRVNREEKG 344
              +  A+G+E  TV+       G++T +E   ++   L    +   + EE+G
Sbjct: 327 SGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEG 379


>gi|21359873 polo-like kinase 1 [Homo sapiens]
          Length = 603

 Score =  133 bits (334), Expect = 4e-31
 Identities = 85/276 (30%), Positives = 143/276 (51%), Gaps = 17/276 (6%)

Query: 4   YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRK----EAVLLAKMKH 59
           Y+  R +G+G F +   +    + ++FA K +  PKS     + R+    E  +   + H
Sbjct: 53  YVRGRFLGKGGFAKCFEISDADTKEVFAGKIV--PKSLLLKPHQREKMSMEISIHRSLAH 110

Query: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
            ++V F   FE    +++V+E C    L++  K++K    PE     +  Q+ LG  ++H
Sbjct: 111 QHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARY--YLRQIVLGCQYLH 168

Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
           + RV+HRD+K  N+FL ++ +VK+GDFG A  +        T  GTP Y+ PE+     +
Sbjct: 169 RNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGH 228

Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239
           + + D+WS+GCI+Y L   K PF+ +  K   L++ +   S +P H +     L+++M +
Sbjct: 229 SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYS-IPKHINPVAASLIQKMLQ 287

Query: 240 RNPSHRPSATTLL------SRGIVARLVQKCL--PP 267
            +P+ RP+   LL      S  I ARL   CL  PP
Sbjct: 288 TDPTARPTINELLNDEFFTSGYIPARLPITCLTIPP 323


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,496,289
Number of Sequences: 37866
Number of extensions: 944967
Number of successful extensions: 6301
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 731
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 3641
Number of HSP's gapped (non-prelim): 1094
length of query: 506
length of database: 18,247,518
effective HSP length: 107
effective length of query: 399
effective length of database: 14,195,856
effective search space: 5664146544
effective search space used: 5664146544
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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