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Search of human proteins with 23510391
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
(506 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 1031 0.0
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 1031 0.0
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 989 0.0
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 331 8e-91
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 312 5e-85
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 257 2e-68
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 220 2e-57
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 220 2e-57
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 220 2e-57
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 203 3e-52
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 201 2e-51
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 188 9e-48
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 175 1e-43
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 175 1e-43
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 171 2e-42
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 160 3e-39
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 144 2e-34
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 142 7e-34
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 142 7e-34
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 142 7e-34
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 141 1e-33
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 140 2e-33
gi|121114283 polo-like kinase 4 [Homo sapiens] 140 4e-33
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 140 4e-33
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 139 5e-33
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 139 6e-33
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 139 6e-33
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 139 8e-33
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 135 9e-32
gi|21359873 polo-like kinase 1 [Homo sapiens] 133 4e-31
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 1031 bits (2667), Expect = 0.0
Identities = 506/506 (100%), Positives = 506/506 (100%)
Query: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
Query: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
Query: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN
Sbjct: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
Query: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
Query: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 300
NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI
Sbjct: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 300
Query: 301 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 360
ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR
Sbjct: 301 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 360
Query: 361 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 420
RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK
Sbjct: 361 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 420
Query: 421 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 480
NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD
Sbjct: 421 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 480
Query: 481 FEEEDDNPDWVSELKKRAGWQGLCDR 506
FEEEDDNPDWVSELKKRAGWQGLCDR
Sbjct: 481 FEEEDDNPDWVSELKKRAGWQGLCDR 506
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 1031 bits (2667), Expect = 0.0
Identities = 506/506 (100%), Positives = 506/506 (100%)
Query: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
Query: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
Query: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN
Sbjct: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
Query: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
Query: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 300
NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI
Sbjct: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 300
Query: 301 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 360
ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR
Sbjct: 301 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 360
Query: 361 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 420
RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK
Sbjct: 361 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 420
Query: 421 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 480
NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD
Sbjct: 421 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 480
Query: 481 FEEEDDNPDWVSELKKRAGWQGLCDR 506
FEEEDDNPDWVSELKKRAGWQGLCDR
Sbjct: 481 FEEEDDNPDWVSELKKRAGWQGLCDR 506
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 989 bits (2557), Expect = 0.0
Identities = 489/506 (96%), Positives = 489/506 (96%), Gaps = 17/506 (3%)
Query: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
Query: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
Query: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN
Sbjct: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
Query: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
Query: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI 300
NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKK
Sbjct: 241 NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKK-------- 292
Query: 301 ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 360
QEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR
Sbjct: 293 ---------QEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR 343
Query: 361 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 420
RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK
Sbjct: 344 RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK 403
Query: 421 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 480
NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD
Sbjct: 404 NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD 463
Query: 481 FEEEDDNPDWVSELKKRAGWQGLCDR 506
FEEEDDNPDWVSELKKRAGWQGLCDR
Sbjct: 464 FEEEDDNPDWVSELKKRAGWQGLCDR 489
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 331 bits (849), Expect = 8e-91
Identities = 151/273 (55%), Positives = 206/273 (75%), Gaps = 1/273 (0%)
Query: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
M+ Y+ L+ IGEGSFG+A+LV+ + + +KEI + + S + SR+E +LA MKH
Sbjct: 1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
PNIV ++ESFE G LYIVM+YC+GGDL ++I QKG LF ED IL+WF Q+CL + H+H
Sbjct: 61 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
+++LHRDIKS+NIFLT++G V+LGDFG AR+L++ + A T +GTPYY+ PEI EN PY
Sbjct: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180
Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239
NNKSDIW+LGC+LYELCTLKH F+A S KNL+LK+ G P+ HYSY+L+ LV Q+FK
Sbjct: 181 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 240
Query: 240 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272
RNP RPS ++L +G +A+ ++K L P++I E
Sbjct: 241 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE 273
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 312 bits (799), Expect = 5e-85
Identities = 148/274 (54%), Positives = 200/274 (72%), Gaps = 2/274 (0%)
Query: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKS-FSNTQNSRKEAVLLAKMKH 59
MD Y V++ IG+G+FG+A L + +S ++ +KEI K + S+KE +LL KMKH
Sbjct: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
PNIVAF SF+ G L+IVMEYCDGGDLM++I +Q+G LF ED IL WF Q+ LG+ HIH
Sbjct: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
Query: 120 KKRVLHRDIKSKNIFLTQNGKV-KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
+++LHRDIK++NIFL++NG V KLGDFG AR+L+N M A T +GTPYY+ PEI +N P
Sbjct: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
YNNK+DIWSLGC+LYELCTLKHPF+ N+ + L+LK+CQ +P+ +S EL L+ Q+F
Sbjct: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240
Query: 239 KRNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272
+ +P RPS ++L R + L+ K L PE+I E
Sbjct: 241 QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQE 274
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 257 bits (656), Expect = 2e-68
Identities = 121/310 (39%), Positives = 193/310 (62%), Gaps = 13/310 (4%)
Query: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNS-RKEAVLLAKMKHPNI 62
Y LR++G+GS+G LV+H + + +K++ L + S + + +EA LL+++KHPNI
Sbjct: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Query: 63 VAFKESFEA-EGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
V +KES+E +G LYIVM +C+GGDL +K+K+QKG+L PE+ ++ WF Q+ + + ++H+K
Sbjct: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
Query: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNN 181
+LHRD+K++N+FLT+ +K+GD G AR+L N A T +GTPYY+ PE++ N PYN
Sbjct: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
Query: 182 KSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRN 241
KSD+W+LGC +YE+ TLKH F A +L+ ++ +G + P+P YS EL L++ M +
Sbjct: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKR 245
Query: 242 PSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRIA 301
P RPS ++L + + R + L +IK SK+N +
Sbjct: 246 PEERPSVRSILRQPYIKRQISFFLE-----------ATKIKTSKNNIKNGDSQSKPFATV 294
Query: 302 LGNEASTVQE 311
+ EA + E
Sbjct: 295 VSGEAESNHE 304
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 220 bits (561), Expect = 2e-57
Identities = 128/367 (34%), Positives = 210/367 (57%), Gaps = 10/367 (2%)
Query: 4 YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59
Y++ + +G GSFG LV + + ++ +KEI + + N T + EA LL+K+ H
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117
P IV F SF + + I+ EYC+G DL KI++ K GK+FPE+ I+ WF Q+ LGV++
Sbjct: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
Query: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
+H++R+LHRD+KSKN+FL +N +K+GDFG +RLL A T GTP+Y+ PE ++
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
Query: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
Y+ KSDIWSL CILYE+C + H F +++ +++LK+ +G LP Y EL +++ M
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267
Query: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKH--NTPRKKTNP 295
+NPS RPSA +L + +Q + M ++ L+ K + H N +K+ +
Sbjct: 268 LNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHL 327
Query: 296 SRIRIALGNEASTVQEEEQDRKGSHTDLESIN-ENLVESALRRVNREEKGNKSVHLRKAS 354
+R + T +E + RK D ++ + +VE ++ + +S + ++ S
Sbjct: 328 QTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLS 387
Query: 355 SPNLHRR 361
LH +
Sbjct: 388 VDVLHEK 394
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 220 bits (561), Expect = 2e-57
Identities = 128/367 (34%), Positives = 210/367 (57%), Gaps = 10/367 (2%)
Query: 4 YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59
Y++ + +G GSFG LV + + ++ +KEI + + N T + EA LL+K+ H
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117
P IV F SF + + I+ EYC+G DL KI++ K GK+FPE+ I+ WF Q+ LGV++
Sbjct: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
Query: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
+H++R+LHRD+KSKN+FL +N +K+GDFG +RLL A T GTP+Y+ PE ++
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
Query: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
Y+ KSDIWSL CILYE+C + H F +++ +++LK+ +G LP Y EL +++ M
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267
Query: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKH--NTPRKKTNP 295
+NPS RPSA +L + +Q + M ++ L+ K + H N +K+ +
Sbjct: 268 LNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHL 327
Query: 296 SRIRIALGNEASTVQEEEQDRKGSHTDLESIN-ENLVESALRRVNREEKGNKSVHLRKAS 354
+R + T +E + RK D ++ + +VE ++ + +S + ++ S
Sbjct: 328 QTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLS 387
Query: 355 SPNLHRR 361
LH +
Sbjct: 388 VDVLHEK 394
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 220 bits (561), Expect = 2e-57
Identities = 128/367 (34%), Positives = 210/367 (57%), Gaps = 10/367 (2%)
Query: 4 YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59
Y++ + +G GSFG LV + + ++ +KEI + + N T + EA LL+K+ H
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117
P IV F SF + + I+ EYC+G DL KI++ K GK+FPE+ I+ WF Q+ LGV++
Sbjct: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
Query: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
+H++R+LHRD+KSKN+FL +N +K+GDFG +RLL A T GTP+Y+ PE ++
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
Query: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
Y+ KSDIWSL CILYE+C + H F +++ +++LK+ +G LP Y EL +++ M
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267
Query: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKH--NTPRKKTNP 295
+NPS RPSA +L + +Q + M ++ L+ K + H N +K+ +
Sbjct: 268 LNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHL 327
Query: 296 SRIRIALGNEASTVQEEEQDRKGSHTDLESIN-ENLVESALRRVNREEKGNKSVHLRKAS 354
+R + T +E + RK D ++ + +VE ++ + +S + ++ S
Sbjct: 328 QTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLS 387
Query: 355 SPNLHRR 361
LH +
Sbjct: 388 VDVLHEK 394
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 203 bits (517), Expect = 3e-52
Identities = 133/377 (35%), Positives = 191/377 (50%), Gaps = 30/377 (7%)
Query: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHP 60
+DY VL IG GS+GR ++ +S ++ KE+ + + Q E LL ++KHP
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 61 NIVAFKESF--EAEGHLYIVMEYCDGGDLMQKIKQ--QKGKLFPEDMILNWFTQMCLGVN 116
NIV + + LYIVMEYC+GGDL I + ++ + E+ +L TQ+ L +
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 117 HIHKKR-----VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPP 171
H++ VLHRD+K N+FL VKLGDFG AR+L++ +FA T+VGTPYY+ P
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 172 EIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQ 231
E + YN KSDIWSLGC+LYELC L PF A S K L K+ +G +P YS EL
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
Query: 232 FLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRK 291
++ +M HRPS +L ++A +++ + LE + + P K
Sbjct: 246 EIITRMLNLKDYHRPSVEEILENPLIA---------DLVADEQRRNLER-RGRQLGEPEK 295
Query: 292 KTNPSRIRIALGNEASTVQEEEQDRKGSHTDLES------INENLVESALRRVNREEKGN 345
+ S + L + +QE E+ K LE + E L E L R K
Sbjct: 296 SQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNY 355
Query: 346 KSVHLRK----ASSPNL 358
+ RK AS+P L
Sbjct: 356 SLLKERKFLSLASNPEL 372
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 201 bits (510), Expect = 2e-51
Identities = 105/259 (40%), Positives = 162/259 (62%), Gaps = 3/259 (1%)
Query: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHPNI 62
Y+ +R++G G+FG A L + + + KE+ L + S +++ E V+LA ++H NI
Sbjct: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Query: 63 VAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKR 122
+A+ F L I +EYC+GG+L KI +QK KLF E+M++ + Q+ V+ IHK
Sbjct: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171
Query: 123 VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNK 182
+LHRDIK+ NIFLT+ +KLGD+G A+ L++ + A T VGTPYY+ PE+ + + YN K
Sbjct: 172 ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFK 231
Query: 183 SDIWSLGCILYELCTLKHPFQANSWKNLILKVCQG--CISPLPSHYSYELQFLVKQMFKR 240
SDIW++GC+++EL TLK F A + NL +K+ QG + S YS EL +V +
Sbjct: 232 SDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQ 291
Query: 241 NPSHRPSATTLLSRGIVAR 259
+P RP+A LL R ++ +
Sbjct: 292 DPEQRPTADELLDRPLLRK 310
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 188 bits (478), Expect = 9e-48
Identities = 96/261 (36%), Positives = 161/261 (61%), Gaps = 3/261 (1%)
Query: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
M+ Y +R++G G+FG L ++ ++ +K+I + + + Q ++ E +L + H
Sbjct: 1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
PN++ + E+F + L I MEY GG L + I+++ L E+ IL++F Q+ L ++H+H
Sbjct: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120
Query: 120 KKRVLHRDIKSKNIFLTQNGKV-KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
+LHRD+K++NI L ++ V K+GDFG +++LS+ A T VGTP Y+ PE+ E P
Sbjct: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKP 179
Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
YN KSDIW+LGC+LYEL +LK F+A + L+LK+ G +P+ YS EL+ LV +
Sbjct: 180 YNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLL 239
Query: 239 KRNPSHRPSATTLLSRGIVAR 259
P+ RP + ++++ + R
Sbjct: 240 SLEPAQRPPLSHIMAQPLCIR 260
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 175 bits (443), Expect = 1e-43
Identities = 98/251 (39%), Positives = 140/251 (55%), Gaps = 7/251 (2%)
Query: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNT--QNSRKEAVLLAKMKHP 60
D+ + + IG G F + A+K++++ + Q+ KE LL ++ HP
Sbjct: 78 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 137
Query: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
NI+ + +SF + L IV+E D GDL Q IK +++ +L PE + +F Q+C V H+
Sbjct: 138 NIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHM 197
Query: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
H +RV+HRDIK N+F+T G VKLGD G R S+ A + VGTPYY+ PE
Sbjct: 198 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENG 257
Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLP-SHYSYELQFLVK 235
YN KSDIWSLGC+LYE+ L+ PF + +L K+ Q PLP HYS +L+ LV
Sbjct: 258 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVS 317
Query: 236 QMFKRNPSHRP 246
+P RP
Sbjct: 318 MCICPDPHQRP 328
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 175 bits (443), Expect = 1e-43
Identities = 98/251 (39%), Positives = 140/251 (55%), Gaps = 7/251 (2%)
Query: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNT--QNSRKEAVLLAKMKHP 60
D+ + + IG G F + A+K++++ + Q+ KE LL ++ HP
Sbjct: 44 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 103
Query: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
NI+ + +SF + L IV+E D GDL Q IK +++ +L PE + +F Q+C V H+
Sbjct: 104 NIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHM 163
Query: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
H +RV+HRDIK N+F+T G VKLGD G R S+ A + VGTPYY+ PE
Sbjct: 164 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENG 223
Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLP-SHYSYELQFLVK 235
YN KSDIWSLGC+LYE+ L+ PF + +L K+ Q PLP HYS +L+ LV
Sbjct: 224 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVS 283
Query: 236 QMFKRNPSHRP 246
+P RP
Sbjct: 284 MCICPDPHQRP 294
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 171 bits (432), Expect = 2e-42
Identities = 99/269 (36%), Positives = 144/269 (53%), Gaps = 10/269 (3%)
Query: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSR--KEAVLLAKMKHP 60
++ + + IG G F A+K++++ + KE LL ++ HP
Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92
Query: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
N++ + SF + L IV+E D GDL + IK +++ +L PE + +F Q+C + H+
Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152
Query: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
H +RV+HRDIK N+F+T G VKLGD G R S+ A + VGTPYY+ PE
Sbjct: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212
Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLPS-HYSYELQFLVK 235
YN KSDIWSLGC+LYE+ L+ PF + +L K+ Q PLPS HYS EL+ LV
Sbjct: 213 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVN 272
Query: 236 QMFKRNPSHRPSATTLLSRGIVARLVQKC 264
+P RP T + VA+ + C
Sbjct: 273 MCINPDPEKRPDVTYVYD---VAKRMHAC 298
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 160 bits (405), Expect = 3e-39
Identities = 108/328 (32%), Positives = 175/328 (53%), Gaps = 14/328 (4%)
Query: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEI-RLPKSFSNTQNSRKEAVLLAKMKH 59
M+ Y VL MIGEGSFGR + + S Q+ A+K I +L +S +N ++E ++ ++H
Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH 60
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
PNIV +SFE + + +V +Y +G +L Q I + GKL PED + Q+ + ++H
Sbjct: 61 PNIVHMLDSFETDKEVVVVTDYAEG-ELFQ-ILEDDGKL-PEDQVQAIAAQLVSALYYLH 117
Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
R+LHRD+K +NI L + G +KL DFG AR +S + GTP Y+ PE+ E PY
Sbjct: 118 SHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPY 177
Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239
++ +D+WS+GCILYEL PF A S L+ + + + PS S + ++ +
Sbjct: 178 DHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVR-WPSTISPCFKNFLQGLLT 236
Query: 240 RNPSHRPSATTLLSRGIVA---RLVQKCLPPEIIMEYGEEV---LEEIKNSKHNTPRKKT 293
++P R S LL +A ++ + P++ + + L+ +K+ + + K
Sbjct: 237 KDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKG 296
Query: 294 NPSRIRIALGNEASTVQEEEQDRKGSHT 321
N SRI L + EE +K +T
Sbjct: 297 NQSRI---LTQAYKRMAEEAMQKKHQNT 321
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 144 bits (362), Expect = 2e-34
Identities = 81/248 (32%), Positives = 141/248 (56%), Gaps = 9/248 (3%)
Query: 4 YMVLRMIGEGSFGRALLV---QHESSNQMFAMKEIRLPKSFSN---TQNSRKEAVLLAKM 57
+ +LR++G+G +G+ V Q + +++AMK +R K N T ++R E +L +
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 58 KHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNH 117
KHP IV +F+ G LY+++E GG+L ++++ +F ED + ++ L + H
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREG--IFLEDTACFYLAEITLALGH 184
Query: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
+H + +++RD+K +NI L+ G +KL DFG + + A T+ GT Y+ PEI
Sbjct: 185 LHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRS 244
Query: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
+N D WSLG ++Y++ T PF A + K + K+ +G ++ LP + + + + LVK+
Sbjct: 245 GHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLA-LPPYLTPDARDLVKKF 303
Query: 238 FKRNPSHR 245
KRNPS R
Sbjct: 304 LKRNPSQR 311
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 142 bits (358), Expect = 7e-34
Identities = 77/249 (30%), Positives = 143/249 (57%), Gaps = 13/249 (5%)
Query: 4 YMVLRMIGEGSFGRALLVQ---HESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
+ +L+++G+GSFG+ LV+ S ++AMK ++ + ++ E +LA + H
Sbjct: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 130
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
P +V +F+ EG LY+++++ GGDL ++ ++ +F E+ + + ++ LG++H+H
Sbjct: 131 PFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALGLDHLH 188
Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
+++RD+K +NI L + G +KL DFG ++ + A ++ GT Y+ PE+ +
Sbjct: 189 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 248
Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWK---NLILKVCQGCISPLPSHYSYELQFLVKQ 236
++ +D WS G +++E+ T PFQ K LILK G +P S E Q L++
Sbjct: 249 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG----MPQFLSTEAQSLLRA 304
Query: 237 MFKRNPSHR 245
+FKRNP++R
Sbjct: 305 LFKRNPANR 313
Score = 100 bits (248), Expect = 4e-21
Identities = 74/261 (28%), Positives = 129/261 (49%), Gaps = 16/261 (6%)
Query: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
D Y+V IG GS+ H+++N +A+K I S S + +LL +HPN
Sbjct: 425 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVI----DKSKRDPSEEIEILLRYGQHPN 480
Query: 62 IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
I+ K+ ++ H+Y+V E GG+L+ KI +Q K F E + V ++H +
Sbjct: 481 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKTVEYLHSQ 538
Query: 122 RVLHRDIKSKNI-FLTQNGK---VKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
V+HRD+K NI ++ ++G +++ DFG A+ L T T +V PE+ +
Sbjct: 539 GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ 598
Query: 178 PYNNKSDIWSLGCILYELCTLKHPF---QANSWKNLILKVCQGCISPLPSHY---SYELQ 231
Y+ DIWSLG +LY + PF +++ + ++ ++ G + ++ S +
Sbjct: 599 GYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAK 658
Query: 232 FLVKQMFKRNPSHRPSATTLL 252
LV +M +P R +A +L
Sbjct: 659 DLVSKMLHVDPHQRLTAKQVL 679
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 142 bits (358), Expect = 7e-34
Identities = 77/249 (30%), Positives = 143/249 (57%), Gaps = 13/249 (5%)
Query: 4 YMVLRMIGEGSFGRALLVQ---HESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
+ +L+++G+GSFG+ LV+ S ++AMK ++ + ++ E +LA + H
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 121
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
P +V +F+ EG LY+++++ GGDL ++ ++ +F E+ + + ++ LG++H+H
Sbjct: 122 PFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALGLDHLH 179
Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
+++RD+K +NI L + G +KL DFG ++ + A ++ GT Y+ PE+ +
Sbjct: 180 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 239
Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWK---NLILKVCQGCISPLPSHYSYELQFLVKQ 236
++ +D WS G +++E+ T PFQ K LILK G +P S E Q L++
Sbjct: 240 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG----MPQFLSTEAQSLLRA 295
Query: 237 MFKRNPSHR 245
+FKRNP++R
Sbjct: 296 LFKRNPANR 304
Score = 100 bits (248), Expect = 4e-21
Identities = 74/261 (28%), Positives = 129/261 (49%), Gaps = 16/261 (6%)
Query: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
D Y+V IG GS+ H+++N +A+K I S S + +LL +HPN
Sbjct: 416 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVI----DKSKRDPSEEIEILLRYGQHPN 471
Query: 62 IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
I+ K+ ++ H+Y+V E GG+L+ KI +Q K F E + V ++H +
Sbjct: 472 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKTVEYLHSQ 529
Query: 122 RVLHRDIKSKNI-FLTQNGK---VKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
V+HRD+K NI ++ ++G +++ DFG A+ L T T +V PE+ +
Sbjct: 530 GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ 589
Query: 178 PYNNKSDIWSLGCILYELCTLKHPF---QANSWKNLILKVCQGCISPLPSHY---SYELQ 231
Y+ DIWSLG +LY + PF +++ + ++ ++ G + ++ S +
Sbjct: 590 GYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAK 649
Query: 232 FLVKQMFKRNPSHRPSATTLL 252
LV +M +P R +A +L
Sbjct: 650 DLVSKMLHVDPHQRLTAKQVL 670
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 142 bits (358), Expect = 7e-34
Identities = 85/283 (30%), Positives = 149/283 (52%), Gaps = 9/283 (3%)
Query: 10 IGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESF 69
+G+G+FG+ +++ + + A K I KS ++ E +LA HP IV ++
Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIET-KSEEELEDYIVEIEILATCDHPYIVKLLGAY 100
Query: 70 EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIK 129
+G L+I++E+C GG + I + + E I QM +N +H KR++HRD+K
Sbjct: 101 YHDGKLWIMIEFCPGG-AVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLK 159
Query: 130 SKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEI-----WENLPYNNKSD 184
+ N+ +T G ++L DFG + + +++GTPY++ PE+ ++ PY+ K+D
Sbjct: 160 AGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKAD 219
Query: 185 IWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPL--PSHYSYELQFLVKQMFKRNP 242
IWSLG L E+ ++ P + ++LK+ + L PS +S E + +K +NP
Sbjct: 220 IWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNP 279
Query: 243 SHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSK 285
RPSA LL V+ + E++ E EV+EEI++ +
Sbjct: 280 ETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGR 322
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 141 bits (356), Expect = 1e-33
Identities = 76/249 (30%), Positives = 146/249 (58%), Gaps = 13/249 (5%)
Query: 4 YMVLRMIGEGSFGRALLVQHES---SNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
+ +L+++G+GSFG+ LV+ ++ + Q++AMK ++ + ++ E +L ++ H
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNH 132
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
P IV +F+ EG LY+++++ GGD+ ++ ++ LF E+ + + ++ L ++H+H
Sbjct: 133 PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEV--LFTEEDVKFYLAELALALDHLH 190
Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
+ +++RD+K +NI L + G +KL DFG ++ + A ++ GT Y+ PE+ +
Sbjct: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 250
Query: 180 NNKSDIWSLGCILYELCTLKHPFQA---NSWKNLILKVCQGCISPLPSHYSYELQFLVKQ 236
+ +D WS G +++E+ T PFQ N N+ILK G +P S E Q L++
Sbjct: 251 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLG----MPQFLSAEAQSLLRM 306
Query: 237 MFKRNPSHR 245
+FKRNP++R
Sbjct: 307 LFKRNPANR 315
Score = 88.6 bits (218), Expect = 1e-17
Identities = 69/259 (26%), Positives = 120/259 (46%), Gaps = 16/259 (6%)
Query: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIV 63
Y + IG GS+ H ++N FA+K I S S + +L+ +HPNI+
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKII----DKSKRDPSEEIEILMRYGQHPNII 481
Query: 64 AFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRV 123
K+ F+ ++Y+V + GG+L+ +I +Q K F E + + V+++H + V
Sbjct: 482 TLKDVFDDGRYVYLVTDLMKGGELLDRILKQ--KCFSEREASDILYVISKTVDYLHCQGV 539
Query: 124 LHRDIKSKNIFLTQNG----KVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
+HRD+K NI +++ DFG A+ L T T +V PE+ Y
Sbjct: 540 VHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGY 599
Query: 180 NNKSDIWSLGCILYELCTLKHPF---QANSWKNLILKVCQGCISPLPSHY---SYELQFL 233
+ DIWSLG + Y + PF ++ + ++L++ G S ++ S + L
Sbjct: 600 DAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDL 659
Query: 234 VKQMFKRNPSHRPSATTLL 252
+ M +P R +A +L
Sbjct: 660 LSHMLHMDPHQRYTAEQIL 678
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 140 bits (354), Expect = 2e-33
Identities = 77/251 (30%), Positives = 144/251 (57%), Gaps = 9/251 (3%)
Query: 4 YMVLRMIGEGSFGRALLVQH---ESSNQMFAMKEIR---LPKSFSNTQNSRKEAVLLAKM 57
+ +LR++G+G +G+ V+ ++ ++FAMK ++ + ++ +T +++ E +L ++
Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150
Query: 58 KHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNH 117
KHP IV +F+ G LY+++EY GG+L +++++ +F ED + ++ + + H
Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEISMALGH 208
Query: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
+H+K +++RD+K +NI L G VKL DFG + + T+ GT Y+ PEI
Sbjct: 209 LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 268
Query: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
+N D WSLG ++Y++ T PF + K I K+ + C LP + + E + L+K++
Sbjct: 269 GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK-CKLNLPPYLTQEARDLLKKL 327
Query: 238 FKRNPSHRPSA 248
KRN + R A
Sbjct: 328 LKRNAASRLGA 338
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 140 bits (352), Expect = 4e-33
Identities = 80/261 (30%), Positives = 138/261 (52%), Gaps = 4/261 (1%)
Query: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSN--TQNSRKEAVLLAKMK 58
++D+ V ++G+GSF + + A+K I + Q + E + ++K
Sbjct: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
Query: 59 HPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHI 118
HP+I+ FE ++Y+V+E C G++ + +K + K F E+ ++ Q+ G+ ++
Sbjct: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRV-KPFSENEARHFMHQIITGMLYL 127
Query: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
H +LHRD+ N+ LT+N +K+ DFG A L P T GTP Y+ PEI
Sbjct: 128 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA 187
Query: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
+ +SD+WSLGC+ Y L + PF ++ KN + KV +PS S E + L+ Q+
Sbjct: 188 HGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYE-MPSFLSIEAKDLIHQLL 246
Query: 239 KRNPSHRPSATTLLSRGIVAR 259
+RNP+ R S +++L ++R
Sbjct: 247 RRNPADRLSLSSVLDHPFMSR 267
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 140 bits (352), Expect = 4e-33
Identities = 99/358 (27%), Positives = 182/358 (50%), Gaps = 20/358 (5%)
Query: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
D + ++ +G+G+FG+ Q++ ++ + A K I KS ++ E +LA HPN
Sbjct: 32 DFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDT-KSEEELEDYMVEIDILASCDHPN 90
Query: 62 IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
IV ++F E +L+I++E+C GG + + + + E I Q +N++H
Sbjct: 91 IVKLLDAFYYENNLWILIEFCAGG-AVDAVMLELERPLTESQIQVVCKQTLDALNYLHDN 149
Query: 122 RVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEI-----WEN 176
+++HRD+K+ NI T +G +KL DFG + + + +++GTPY++ PE+ ++
Sbjct: 150 KIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKD 209
Query: 177 LPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPL--PSHYSYELQFLV 234
PY+ K+D+WSLG L E+ ++ P + ++LK+ + L PS +S + +
Sbjct: 210 RPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFL 269
Query: 235 KQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTN 294
K+ ++N R + + LL V K + E+I E EV EE+++ K ++T
Sbjct: 270 KKCLEKNVDARWTTSQLLQHPFVTVDSNKPI-RELIAEAKAEVTEEVEDGKEEDEEEETE 328
Query: 295 PSRIRIALGNEAS---TVQEEEQDRKGSHT-DLESINENLVESALRRVNREEKGNKSV 348
S + I AS ++ E+D+ + LES++E R N E+K N +
Sbjct: 329 NS-LPIPASKRASSDLSIASSEEDKLSQNACILESVSEK-----TERSNSEDKLNSKI 380
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 139 bits (351), Expect = 5e-33
Identities = 73/249 (29%), Positives = 142/249 (57%), Gaps = 7/249 (2%)
Query: 4 YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
+ +L+++G+GSFG+ LV+ S + Q++AMK ++ + ++ E +L ++ H
Sbjct: 68 FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNH 127
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
P IV +F+ EG LY+++++ GGDL ++ ++ +F E+ + + ++ L ++H+H
Sbjct: 128 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALALDHLH 185
Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
+++RD+K +NI L + G +KL DFG ++ + A ++ GT Y+ PE+ +
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGH 245
Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239
+D WS G +++E+ T PFQ K + + + + +P S E Q L++ +FK
Sbjct: 246 TQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLG-MPQFLSPEAQSLLRMLFK 304
Query: 240 RNPSHRPSA 248
RNP++R A
Sbjct: 305 RNPANRLGA 313
Score = 98.2 bits (243), Expect = 2e-20
Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 16/261 (6%)
Query: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
D Y V IG GS+ H+++N FA+K I S + + +LL +HPN
Sbjct: 420 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKII----DKSKRDPTEEIEILLRYGQHPN 475
Query: 62 IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
I+ K+ ++ ++Y+V E GG+L+ KI +QK F E + V ++H +
Sbjct: 476 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQK--FFSEREASAVLFTITKTVEYLHAQ 533
Query: 122 RVLHRDIKSKNI-FLTQNGK---VKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
V+HRD+K NI ++ ++G +++ DFG A+ L T T +V PE+ +
Sbjct: 534 GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ 593
Query: 178 PYNNKSDIWSLGCILYELCTLKHPF---QANSWKNLILKVCQGCISPLPSHY---SYELQ 231
Y+ DIWSLG +LY + T PF ++ + ++ ++ G S ++ S +
Sbjct: 594 GYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAK 653
Query: 232 FLVKQMFKRNPSHRPSATTLL 252
LV +M +P R +A +L
Sbjct: 654 DLVSKMLHVDPHQRLTAALVL 674
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 139 bits (350), Expect = 6e-33
Identities = 77/252 (30%), Positives = 142/252 (56%), Gaps = 13/252 (5%)
Query: 4 YMVLRMIGEGSFGRALLVQH---ESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
+ +L+++G+GS+G+ LV+ + Q++AMK ++ + S+ E +LA++ H
Sbjct: 67 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNH 126
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
P IV +F+ EG LY+++++ GGDL ++ ++ +F E+ + + ++ L ++H+H
Sbjct: 127 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALALDHLH 184
Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
+++RD+K +NI L + G +K+ DFG ++ + A ++ GT Y+ PE+ +
Sbjct: 185 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGH 244
Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKN---LILKVCQGCISPLPSHYSYELQFLVKQ 236
+D WS G +++E+ T PFQ K LILK G +P S E Q L++
Sbjct: 245 TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLG----MPQFLSGEAQSLLRA 300
Query: 237 MFKRNPSHRPSA 248
+FKRNP +R A
Sbjct: 301 LFKRNPCNRLGA 312
Score = 89.7 bits (221), Expect = 5e-18
Identities = 59/205 (28%), Positives = 100/205 (48%), Gaps = 10/205 (4%)
Query: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
D Y + IG GS+ H++++ +A+K I S S + +LL +HPN
Sbjct: 421 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKII----DKSKRDPSEEIEILLRYGQHPN 476
Query: 62 IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
I+ K+ ++ +Y+VME GG+L+ +I +Q + F E + + ++++H +
Sbjct: 477 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQ--RYFSEREASDVLCTITKTMDYLHSQ 534
Query: 122 RVLHRDIKSKNIFLTQNG----KVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
V+HRD+K NI +++ DFG A+ L T T +V PE+ +
Sbjct: 535 GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQ 594
Query: 178 PYNNKSDIWSLGCILYELCTLKHPF 202
Y+ DIWSLG +LY + PF
Sbjct: 595 GYDAACDIWSLGILLYTMLAGFTPF 619
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 139 bits (350), Expect = 6e-33
Identities = 77/252 (30%), Positives = 142/252 (56%), Gaps = 13/252 (5%)
Query: 4 YMVLRMIGEGSFGRALLVQH---ESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
+ +L+++G+GS+G+ LV+ + Q++AMK ++ + S+ E +LA++ H
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNH 118
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
P IV +F+ EG LY+++++ GGDL ++ ++ +F E+ + + ++ L ++H+H
Sbjct: 119 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALALDHLH 176
Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
+++RD+K +NI L + G +K+ DFG ++ + A ++ GT Y+ PE+ +
Sbjct: 177 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGH 236
Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKN---LILKVCQGCISPLPSHYSYELQFLVKQ 236
+D WS G +++E+ T PFQ K LILK G +P S E Q L++
Sbjct: 237 TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLG----MPQFLSGEAQSLLRA 292
Query: 237 MFKRNPSHRPSA 248
+FKRNP +R A
Sbjct: 293 LFKRNPCNRLGA 304
Score = 89.7 bits (221), Expect = 5e-18
Identities = 59/205 (28%), Positives = 100/205 (48%), Gaps = 10/205 (4%)
Query: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPN 61
D Y + IG GS+ H++++ +A+K I S S + +LL +HPN
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKII----DKSKRDPSEEIEILLRYGQHPN 468
Query: 62 IVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKK 121
I+ K+ ++ +Y+VME GG+L+ +I +Q + F E + + ++++H +
Sbjct: 469 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQ--RYFSEREASDVLCTITKTMDYLHSQ 526
Query: 122 RVLHRDIKSKNIFLTQNG----KVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
V+HRD+K NI +++ DFG A+ L T T +V PE+ +
Sbjct: 527 GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQ 586
Query: 178 PYNNKSDIWSLGCILYELCTLKHPF 202
Y+ DIWSLG +LY + PF
Sbjct: 587 GYDAACDIWSLGILLYTMLAGFTPF 611
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 139 bits (349), Expect = 8e-33
Identities = 104/369 (28%), Positives = 171/369 (46%), Gaps = 21/369 (5%)
Query: 6 VLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAF 65
VL +GEGS+G H+ S Q+ A+K++ + S+ Q KE ++ + P +V +
Sbjct: 29 VLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEISIMQQCDSPYVVKY 85
Query: 66 KESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLH 125
S+ L+IVMEYC G + I+ + K ED I G+ ++H R +H
Sbjct: 86 YGSYFKNTDLWIVMEYCGAGSVSDIIRL-RNKTLIEDEIATILKSTLKGLEYLHFMRKIH 144
Query: 126 RDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDI 185
RDIK+ NI L G KL DFG A L++ MA T +GTP+++ PE+ + + YN +DI
Sbjct: 145 RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 204
Query: 186 WSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPL--PSHYSYELQFLVKQMFKRNPS 243
WSLG E+ K P+ I + P +S + VK+ +NP
Sbjct: 205 WSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPE 264
Query: 244 HRPSATTLLSR---------GIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTN 294
R +AT LL I+ L+ + + EI + EE E++ + N+ + +
Sbjct: 265 QRATATQLLQHPFIKNAKPVSILRDLITEAM--EIKAKRHEEQQRELEEEEENSDEDELD 322
Query: 295 PSRIRIALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRV---NREEKGNKSVHLR 351
+ T++ +G+ T +E N ++ES L + + +E+ R
Sbjct: 323 SHTMVKTSVESVGTMRATSTMSEGAQTMIEH-NSTMLESDLGTMVINSEDEEEEDGTMKR 381
Query: 352 KASSPNLHR 360
A+SP + R
Sbjct: 382 NATSPQVQR 390
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 135 bits (340), Expect = 9e-32
Identities = 97/353 (27%), Positives = 167/353 (47%), Gaps = 19/353 (5%)
Query: 6 VLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAF 65
VL +GEGS+G H+ + Q+ A+K++ + S+ Q KE ++ + P++V +
Sbjct: 32 VLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE---SDLQEIIKEISIMQQCDSPHVVKY 88
Query: 66 KESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLH 125
S+ L+IVMEYC G + I+ + K ED I G+ ++H R +H
Sbjct: 89 YGSYFKNTDLWIVMEYCGAGSVSDIIRL-RNKTLTEDEIATILQSTLKGLEYLHFMRKIH 147
Query: 126 RDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDI 185
RDIK+ NI L G KL DFG A L++ MA T +GTP+++ PE+ + + YN +DI
Sbjct: 148 RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 207
Query: 186 WSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPL--PSHYSYELQFLVKQMFKRNPS 243
WSLG E+ K P+ I + P +S VKQ ++P
Sbjct: 208 WSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 244 HRPSATTLLSR---------GIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTN 294
R +AT LL I+ L+ + + ++ + ++ E ++ + N+ + +
Sbjct: 268 QRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQ-REVDQDDEENSEEDEMD 326
Query: 295 PSRIRIALGNEASTVQEEEQDRKGSHTDLE---SINENLVESALRRVNREEKG 344
+ A+G+E TV+ G++T +E ++ L + + EE+G
Sbjct: 327 SGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEG 379
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 133 bits (334), Expect = 4e-31
Identities = 85/276 (30%), Positives = 143/276 (51%), Gaps = 17/276 (6%)
Query: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRK----EAVLLAKMKH 59
Y+ R +G+G F + + + ++FA K + PKS + R+ E + + H
Sbjct: 53 YVRGRFLGKGGFAKCFEISDADTKEVFAGKIV--PKSLLLKPHQREKMSMEISIHRSLAH 110
Query: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
++V F FE +++V+E C L++ K++K PE + Q+ LG ++H
Sbjct: 111 QHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARY--YLRQIVLGCQYLH 168
Query: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
+ RV+HRD+K N+FL ++ +VK+GDFG A + T GTP Y+ PE+ +
Sbjct: 169 RNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGH 228
Query: 180 NNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFK 239
+ + D+WS+GCI+Y L K PF+ + K L++ + S +P H + L+++M +
Sbjct: 229 SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYS-IPKHINPVAASLIQKMLQ 287
Query: 240 RNPSHRPSATTLL------SRGIVARLVQKCL--PP 267
+P+ RP+ LL S I ARL CL PP
Sbjct: 288 TDPTARPTINELLNDEFFTSGYIPARLPITCLTIPP 323
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,496,289
Number of Sequences: 37866
Number of extensions: 944967
Number of successful extensions: 6301
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 731
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 3641
Number of HSP's gapped (non-prelim): 1094
length of query: 506
length of database: 18,247,518
effective HSP length: 107
effective length of query: 399
effective length of database: 14,195,856
effective search space: 5664146544
effective search space used: 5664146544
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.