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Search of human proteins with 23510364
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23510364 protein-tyrosine kinase fyn isoform c [Homo
sapiens]
(482 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 995 0.0
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 971 0.0
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 950 0.0
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 717 0.0
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 690 0.0
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 690 0.0
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 690 0.0
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 669 0.0
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 669 0.0
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 537 e-153
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 510 e-145
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 510 e-145
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 503 e-142
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 503 e-142
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 490 e-138
gi|4503787 fyn-related kinase [Homo sapiens] 374 e-103
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 326 3e-89
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 307 2e-83
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 303 3e-82
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 303 3e-82
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 295 8e-80
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 295 8e-80
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 295 8e-80
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 295 8e-80
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 294 1e-79
gi|148596974 TXK tyrosine kinase [Homo sapiens] 280 2e-75
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 270 2e-72
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 270 3e-72
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 225 6e-59
gi|187475373 c-src tyrosine kinase [Homo sapiens] 224 1e-58
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 995 bits (2572), Expect = 0.0
Identities = 482/482 (100%), Positives = 482/482 (100%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
Query: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
Sbjct: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSGTWNGNTK 240
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSGTWNGNTK
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSGTWNGNTK 240
Query: 241 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLK 300
VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLK
Sbjct: 241 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLK 300
Query: 301 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 360
DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI
Sbjct: 301 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 360
Query: 361 EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV 420
EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV
Sbjct: 361 EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV 420
Query: 421 LEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 480
LEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE
Sbjct: 421 LEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 480
Query: 481 NL 482
NL
Sbjct: 481 NL 482
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 971 bits (2509), Expect = 0.0
Identities = 482/534 (90%), Positives = 482/534 (90%), Gaps = 52/534 (9%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
Query: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
Sbjct: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS-------- 232
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCF 240
Query: 233 --------------------------------------------GTWNGNTKVAIKTLKP 248
GTWNGNTKVAIKTLKP
Sbjct: 241 NLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKP 300
Query: 249 GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK 308
GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK
Sbjct: 301 GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK 360
Query: 309 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR 368
LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR
Sbjct: 361 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR 420
Query: 369 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY 428
QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY
Sbjct: 421 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY 480
Query: 429 RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 482
RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Sbjct: 481 RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 950 bits (2456), Expect = 0.0
Identities = 475/537 (88%), Positives = 478/537 (89%), Gaps = 55/537 (10%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
Query: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
Sbjct: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQF------------------- 221
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQF
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC 240
Query: 222 ----------------------------ETLQ--------QLVQHYSGTWNGNTKVAIKT 245
E+LQ Q + + GTWNGNTKVAIKT
Sbjct: 241 RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT 300
Query: 246 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 305
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
Sbjct: 301 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 360
Query: 306 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 365
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
Sbjct: 361 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 420
Query: 366 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 425
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
Sbjct: 421 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 480
Query: 426 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 482
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Sbjct: 481 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 717 bits (1851), Expect = 0.0
Identities = 367/543 (67%), Positives = 410/543 (75%), Gaps = 61/543 (11%)
Query: 1 MGCVQCKDKE--ATKLTEERDGSLNQSSGYRYGTDPT-----PQHYPSFGVTSIPNYNNF 53
MGC++ K+ + A K E +S YG +PT P + + +
Sbjct: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
Query: 54 HAAGGQGLTVFGGVNSSSHTGTLRTRGGT--GVTLFVALYDYEARTEDDLSFHKGEKFQI 111
G G+T FGG +SS G GVT+FVALYDYEART +DLSF KGE+FQI
Sbjct: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
Query: 112 LNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRG 171
+N++EGDWWEARS+ TG+ GYIPSNYVAP DSIQAEEWYFGK+GRKDAER LL+ GN RG
Sbjct: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
Query: 172 TFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY 231
FL+RESETTKGAYSLSIRDWD+++GD+VKHYKIRKLDNGGYYITTRAQF+TLQ+LV+HY
Sbjct: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
Query: 232 S----------------------------------------------------GTWNGNT 239
+ GTWNG T
Sbjct: 241 TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 300
Query: 240 KVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFL 299
KVAIKTLKPGTM PE+FL+EAQIMKKL+HDKLV LYAVVSEEPIYIVTE+M+KGSLLDFL
Sbjct: 301 KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 360
Query: 300 KDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARL 359
K+G+G+ LKLP LVDMAAQ+A GMAYIERMNYIHRDLR+ANILVG L+CKIADFGLARL
Sbjct: 361 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL 420
Query: 360 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE 419
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL TELVTKGRVPYPGM NRE
Sbjct: 421 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 480
Query: 420 VLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPG 479
VLEQVERGYRMPCPQ CP SLHELM CWKKDP+ERPTFEY+QSFLEDYFTATEPQYQPG
Sbjct: 481 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 540
Query: 480 ENL 482
ENL
Sbjct: 541 ENL 543
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 690 bits (1781), Expect = 0.0
Identities = 354/537 (65%), Positives = 397/537 (73%), Gaps = 67/537 (12%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56
MGCV CK E +E G Y YG DPT P+ IPNY+NF +
Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
Query: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115
+N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
Query: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175
EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
Query: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS--- 232
RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY
Sbjct: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
Query: 233 -------------------------------------------------GTWNGNTKVAI 243
GTWNG+TKVA+
Sbjct: 231 DGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAV 290
Query: 244 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE 303
KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK+ E
Sbjct: 291 KTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPE 350
Query: 304 GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN 363
G+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI+D+
Sbjct: 351 GQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD 410
Query: 364 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 423
EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REVLEQ
Sbjct: 411 EYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470
Query: 424 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 480
VE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 690 bits (1781), Expect = 0.0
Identities = 354/537 (65%), Positives = 397/537 (73%), Gaps = 67/537 (12%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56
MGCV CK E +E G Y YG DPT P+ IPNY+NF +
Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
Query: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115
+N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
Query: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175
EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
Query: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS--- 232
RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY
Sbjct: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
Query: 233 -------------------------------------------------GTWNGNTKVAI 243
GTWNG+TKVA+
Sbjct: 231 DGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAV 290
Query: 244 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE 303
KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK+ E
Sbjct: 291 KTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPE 350
Query: 304 GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN 363
G+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI+D+
Sbjct: 351 GQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD 410
Query: 364 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 423
EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REVLEQ
Sbjct: 411 EYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470
Query: 424 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 480
VE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 690 bits (1781), Expect = 0.0
Identities = 354/537 (65%), Positives = 397/537 (73%), Gaps = 67/537 (12%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56
MGCV CK E +E G Y YG DPT P+ IPNY+NF +
Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
Query: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115
+N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
Query: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175
EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
Query: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS--- 232
RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY
Sbjct: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
Query: 233 -------------------------------------------------GTWNGNTKVAI 243
GTWNG+TKVA+
Sbjct: 231 DGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAV 290
Query: 244 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE 303
KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK+ E
Sbjct: 291 KTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPE 350
Query: 304 GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN 363
G+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI+D+
Sbjct: 351 GQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD 410
Query: 364 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 423
EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REVLEQ
Sbjct: 411 EYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470
Query: 424 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 480
VE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 669 bits (1725), Expect = 0.0
Identities = 333/475 (70%), Positives = 379/475 (79%), Gaps = 56/475 (11%)
Query: 63 VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119
+FGG NSS T T R G GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63 LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
Query: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+ NPRGTFL+RESE
Sbjct: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
Query: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS------- 232
TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS
Sbjct: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
Query: 233 ---------------------------------------------GTWNGNTKVAIKTLK 247
GTWNG T+VAIKTLK
Sbjct: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 301
Query: 248 PGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRAL 307
PGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G+ L
Sbjct: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361
Query: 308 KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTA 367
+LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNEYTA
Sbjct: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421
Query: 368 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG 427
RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QVERG
Sbjct: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481
Query: 428 YRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 482
YRMPCP +CP SLH+LM CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 669 bits (1725), Expect = 0.0
Identities = 333/475 (70%), Positives = 379/475 (79%), Gaps = 56/475 (11%)
Query: 63 VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119
+FGG NSS T T R G GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63 LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
Query: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+ NPRGTFL+RESE
Sbjct: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
Query: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS------- 232
TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS
Sbjct: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
Query: 233 ---------------------------------------------GTWNGNTKVAIKTLK 247
GTWNG T+VAIKTLK
Sbjct: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 301
Query: 248 PGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRAL 307
PGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G+ L
Sbjct: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361
Query: 308 KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTA 367
+LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNEYTA
Sbjct: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421
Query: 368 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG 427
RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QVERG
Sbjct: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481
Query: 428 YRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 482
YRMPCP +CP SLH+LM CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 537 bits (1383), Expect = e-153
Identities = 271/468 (57%), Positives = 338/468 (72%), Gaps = 54/468 (11%)
Query: 62 TVFGGVNS-SSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
T+ G NS +S+T +R G + + VALYDYEA +DLSF KG++ +L S G+WW
Sbjct: 58 TIKPGPNSHNSNTPGIREAGSEDI-IVVALYDYEAIHHEDLSFQKGDQMVVLEES-GEWW 115
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
+ARSL T + GYIPSNYVA VDS++ EEW+F + RKDAERQLL+ GN G+F+IR+SET
Sbjct: 116 KARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSET 175
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS-------- 232
TKG+YSLS+RD+D +GD VKHYKIR LDNGG+YI+ R+ F TLQ+LV HY
Sbjct: 176 TKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQ 235
Query: 233 -------------------------------------------GTWNGNTKVAIKTLKPG 249
T+N +TKVA+KT+KPG
Sbjct: 236 KLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPG 295
Query: 250 TMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKL 309
+MS E+FL EA +MK L+HDKLV+L+AVV++EPIYI+TE+M KGSLLDFLK EG L
Sbjct: 296 SMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPL 355
Query: 310 PNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQ 369
P L+D +AQ+A GMA+IE+ NYIHRDLR+ANILV L+CKIADFGLAR+IEDNEYTAR+
Sbjct: 356 PKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTARE 415
Query: 370 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYR 429
GAKFPIKWTAPEA +G FTIKSDVWSFGILL E+VT GR+PYPGM+N EV+ +ERGYR
Sbjct: 416 GAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYR 475
Query: 430 MPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQ 477
MP P++CP L+ +M+ CWK PEERPTFEY+QS L+D++TATE QYQ
Sbjct: 476 MPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQ 523
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 510 bits (1314), Expect = e-145
Identities = 255/444 (57%), Positives = 320/444 (72%), Gaps = 52/444 (11%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
L +AL+ YE + DL F KGE+ +IL S G+WW+A+SLTTG+ G+IP N+VA +S++
Sbjct: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
E W+F L RKDAERQLL+ GN G+FLIRESE+T G++SLS+RD+D +G+ VKHYKI
Sbjct: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYS--------------------------------- 232
R LDNGG+YI+ R F L +LV+HY+
Sbjct: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRE 243
Query: 233 ------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL 274
G +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +LV+L
Sbjct: 244 TLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRL 303
Query: 275 YAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR 334
YAVV++EPIYI+TEYM GSL+DFLK G L + L+DMAAQ+A GMA+IE NYIHR
Sbjct: 304 YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR 363
Query: 335 DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 394
DLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTIKSDV
Sbjct: 364 DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV 423
Query: 395 WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE 454
WSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM P +CP L++LM CWK+ PE+
Sbjct: 424 WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPED 483
Query: 455 RPTFEYLQSFLEDYFTATEPQYQP 478
RPTF+YL+S LED+FTATE QYQP
Sbjct: 484 RPTFDYLRSVLEDFFTATEGQYQP 507
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 510 bits (1314), Expect = e-145
Identities = 255/444 (57%), Positives = 320/444 (72%), Gaps = 52/444 (11%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
L +AL+ YE + DL F KGE+ +IL S G+WW+A+SLTTG+ G+IP N+VA +S++
Sbjct: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
E W+F L RKDAERQLL+ GN G+FLIRESE+T G++SLS+RD+D +G+ VKHYKI
Sbjct: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYS--------------------------------- 232
R LDNGG+YI+ R F L +LV+HY+
Sbjct: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRE 243
Query: 233 ------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL 274
G +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +LV+L
Sbjct: 244 TLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRL 303
Query: 275 YAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR 334
YAVV++EPIYI+TEYM GSL+DFLK G L + L+DMAAQ+A GMA+IE NYIHR
Sbjct: 304 YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR 363
Query: 335 DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 394
DLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTIKSDV
Sbjct: 364 DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV 423
Query: 395 WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE 454
WSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM P +CP L++LM CWK+ PE+
Sbjct: 424 WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPED 483
Query: 455 RPTFEYLQSFLEDYFTATEPQYQP 478
RPTF+YL+S LED+FTATE QYQP
Sbjct: 484 RPTFDYLRSVLEDFFTATEGQYQP 507
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 503 bits (1296), Expect = e-142
Identities = 251/444 (56%), Positives = 316/444 (71%), Gaps = 53/444 (11%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
+ VALY Y+ DDLSF KGEK ++L G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
EEW+F + RKDAERQLL+ GN G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYS--------------------------------- 232
R LDNGGYYI+ R F + +++HY
Sbjct: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRE 224
Query: 233 ------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL 274
G +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDKLV+L
Sbjct: 225 SIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRL 284
Query: 275 YAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 333
YAVV+ EEPIYI+TEYM KGSLLDFLK EG + LP L+D +AQ+A GMAYIER NYIH
Sbjct: 285 YAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIH 344
Query: 334 RDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 393
RDLR+AN+LV L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKSD
Sbjct: 345 RDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSD 404
Query: 394 VWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE 453
VWSFGILL E+VT G++PYPG N +V+ + +GYRMP ++CP L+++M CWK+ E
Sbjct: 405 VWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAE 464
Query: 454 ERPTFEYLQSFLEDYFTATEPQYQ 477
ERPTF+YLQS L+D++TATE QYQ
Sbjct: 465 ERPTFDYLQSVLDDFYTATEGQYQ 488
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 503 bits (1296), Expect = e-142
Identities = 251/444 (56%), Positives = 316/444 (71%), Gaps = 53/444 (11%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
+ VALY Y+ DDLSF KGEK ++L G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 67 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
EEW+F + RKDAERQLL+ GN G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYS--------------------------------- 232
R LDNGGYYI+ R F + +++HY
Sbjct: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRE 245
Query: 233 ------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL 274
G +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDKLV+L
Sbjct: 246 SIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRL 305
Query: 275 YAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 333
YAVV+ EEPIYI+TEYM KGSLLDFLK EG + LP L+D +AQ+A GMAYIER NYIH
Sbjct: 306 YAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIH 365
Query: 334 RDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 393
RDLR+AN+LV L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKSD
Sbjct: 366 RDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSD 425
Query: 394 VWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE 453
VWSFGILL E+VT G++PYPG N +V+ + +GYRMP ++CP L+++M CWK+ E
Sbjct: 426 VWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAE 485
Query: 454 ERPTFEYLQSFLEDYFTATEPQYQ 477
ERPTF+YLQS L+D++TATE QYQ
Sbjct: 486 ERPTFDYLQSVLDDFYTATEGQYQ 509
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 490 bits (1261), Expect = e-138
Identities = 256/442 (57%), Positives = 309/442 (69%), Gaps = 55/442 (12%)
Query: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
VALYDY A + DL KGEK Q+L + GDWW ARSL TG GY+PSN+VA V+S++ E
Sbjct: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
Query: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
W+F GRK+AERQLL+ N G+FLIRESET KGA+SLS++D +G+ +KHYKIR
Sbjct: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
Query: 208 LDNGGYYITTRAQFETLQQLVQHYS----------------------------------- 232
LD GGYYI+ R F +LQ LVQHYS
Sbjct: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSL 241
Query: 233 ----------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYA 276
G + N KVAIKTLK GTMSPE+FL EA +MK L+H++LV+LYA
Sbjct: 242 RLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYA 301
Query: 277 VVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDL 336
VV++EPIYIVTEYM +G LLDFLK EG L LP L+DM+AQ+A GMAYIERMN IHRDL
Sbjct: 302 VVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDL 361
Query: 337 RSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 396
R+ANILV L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+DVWS
Sbjct: 362 RAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS 420
Query: 397 FGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKDPEER 455
FG+LL E+VT GRVPYPGM+N EV+ +ERGYRMP P CP L+ ++ CW+ PEER
Sbjct: 421 FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER 480
Query: 456 PTFEYLQSFLEDYFTATEPQYQ 477
PTFE+LQS LED++TATE QY+
Sbjct: 481 PTFEFLQSVLEDFYTATERQYE 502
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 374 bits (960), Expect = e-103
Identities = 209/457 (45%), Positives = 270/457 (59%), Gaps = 63/457 (13%)
Query: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETG-------YIPSNYVA 139
FVAL+DY+ART +DLSF G+K Q+L++ WW AR L G YIPSNYVA
Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
Query: 140 PVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMK--- 196
S+QAE W+FG +GR DAE+QLL N G+FLIRESE+ KG +SLS+ D +K
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
Query: 197 --------------------GDHVKHYKIR------KLDNGGYYITTRAQFETLQQLVQH 230
+ V HY KL I A F+ + V
Sbjct: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
Query: 231 YS----------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 268
+ G WN T VA+KTLKPG+M P FL EAQIMK L+H
Sbjct: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRH 286
Query: 269 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 327
KL+QLYAV + E+PIYI+TE M GSL ++L++ G + L VDMAAQVA+GMAY+E
Sbjct: 287 PKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLE 346
Query: 328 RMNYIHRDLRSANILVGNGLICKIADFGLARLIE-DNE--YTARQGAKFPIKWTAPEAAL 384
NYIHRDL + N+LVG I K+ADFGLAR+ + DNE Y +R K P+KWTAPEA
Sbjct: 347 SRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIR 406
Query: 385 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELM 444
+F+IKSDVWSFGILL E++T G++PY GM +V++ + + YR+P P +CP + +M
Sbjct: 407 SNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIM 466
Query: 445 IHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGEN 481
+ CW +P+ERPTFE L+ LEDYF T+ Y N
Sbjct: 467 LECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 326 bits (835), Expect = 3e-89
Identities = 174/444 (39%), Positives = 250/444 (56%), Gaps = 62/444 (13%)
Query: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGET---GYIPSNYVAPVDS 143
+V L+D+++RT+++LSF G+ F + E WW G GY+P NY+A ++
Sbjct: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
Query: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
+++E W+FG + R +A R+L + GN G FLIR SE Y LS+RD V+HY
Sbjct: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
Query: 204 KIRKLDNGGYYITTRAQFETLQQLVQH--------------------------------- 230
KI + G ++ F +L +LV +
Sbjct: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERP 187
Query: 231 ------------------YSGTWNGNTKVAIKTLKPGTMSPESFLE-EAQIMKKLKHDKL 271
+ G W +VAIK + + + L+ E Q MKKL+H +
Sbjct: 188 REEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247
Query: 272 VQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 330
+ LYAVVS +P+YI+TE M KGSLL+ L+D + + L + L+D+A QVA GM Y+E N
Sbjct: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307
Query: 331 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 390
YIHRDL + NILVG +CK+ DFGLARLI+++ Y + P KWTAPEA G ++
Sbjct: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHYST 366
Query: 391 KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK 450
KSDVWSFGILL E+ ++G+VPYPGM+N E +V+ GYRMPCP +CP S+H+LM+ CW +
Sbjct: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426
Query: 451 DPEERPTFEYLQSFLEDYFTATEP 474
DPE+RP F+ L+ L + + P
Sbjct: 427 DPEQRPCFKALRERLSSFTSYENP 450
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 307 bits (786), Expect = 2e-83
Identities = 171/431 (39%), Positives = 238/431 (55%), Gaps = 56/431 (12%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--DS 143
LF+ALYD+ AR +LS +G++ L G + R G +P +VA ++
Sbjct: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114
Query: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
+ + WYF + R A++ LLS N G FLIR SE++ G YSLS+R V HY
Sbjct: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVR-----AQAKVCHY 169
Query: 204 KIRKLDNGGYYITTRAQFETLQQLVQHYS------------------------------- 232
++ +G Y+ F L++L+ +Y
Sbjct: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSE 229
Query: 233 -----------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY 275
G W G+ VAIK +K M +E Q +K L+H++L++L+
Sbjct: 230 FALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLH 289
Query: 276 AVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR 334
AV S EP+YIVTE M KG+L FL EGRAL+LP L+ A QVA GM+Y+E +HR
Sbjct: 290 AVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHR 349
Query: 335 DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 394
DL + N+LV +GL CK+ADFGLARL++D+ Y+ +K P+KWTAPEAA Y F+ KSDV
Sbjct: 350 DLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDV 409
Query: 395 WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE 454
WSFG+LL E+ T G+ PY GM N E L+Q+ RGYR+P P CP ++ LM+ CW+ PEE
Sbjct: 410 WSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEE 469
Query: 455 RPTFEYLQSFL 465
RP+F L+ L
Sbjct: 470 RPSFATLREKL 480
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 303 bits (775), Expect = 3e-82
Identities = 175/442 (39%), Positives = 249/442 (56%), Gaps = 67/442 (15%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L + G+W EA+ T G++PSNY+ PV+S+
Sbjct: 65 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSL 122
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 123 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 175
Query: 205 IRKLDNGGYY------------------------ITT---------------------RA 219
I +G Y ITT +
Sbjct: 176 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 235
Query: 220 QFETLQQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 268
+ E ++H Y G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 236 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 295
Query: 269 DKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 327
LVQL V + EP YI+TE+M G+LLD+L++ + + L+ MA Q+++ M Y+E
Sbjct: 296 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 355
Query: 328 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 387
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y +
Sbjct: 356 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 415
Query: 388 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 447
F+IKSDVW+FG+LL E+ T G PYPG++ +V E +E+ YRM P+ CP ++ELM C
Sbjct: 416 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 475
Query: 448 WKKDPEERPTFEYLQSFLEDYF 469
W+ +P +RP+F + E F
Sbjct: 476 WQWNPSDRPSFAEIHQAFETMF 497
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 303 bits (775), Expect = 3e-82
Identities = 175/442 (39%), Positives = 249/442 (56%), Gaps = 67/442 (15%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L + G+W EA+ T G++PSNY+ PV+S+
Sbjct: 84 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSL 141
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 142 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 194
Query: 205 IRKLDNGGYY------------------------ITT---------------------RA 219
I +G Y ITT +
Sbjct: 195 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 254
Query: 220 QFETLQQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 268
+ E ++H Y G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 255 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 314
Query: 269 DKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 327
LVQL V + EP YI+TE+M G+LLD+L++ + + L+ MA Q+++ M Y+E
Sbjct: 315 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 374
Query: 328 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 387
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y +
Sbjct: 375 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 434
Query: 388 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 447
F+IKSDVW+FG+LL E+ T G PYPG++ +V E +E+ YRM P+ CP ++ELM C
Sbjct: 435 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 494
Query: 448 WKKDPEERPTFEYLQSFLEDYF 469
W+ +P +RP+F + E F
Sbjct: 495 WQWNPSDRPSFAEIHQAFETMF 516
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 295 bits (754), Expect = 8e-80
Identities = 178/450 (39%), Positives = 246/450 (54%), Gaps = 57/450 (12%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKG-----------AYSLSIRDWD 193
+ WY G + R AE L S N G+FL+RESE++ G Y I
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 194 DMK----------------------GDHVK---HYKIRKLDNGGYY----ITTRAQFETL 224
D K D + HY K + Y I + + E
Sbjct: 212 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT 271
Query: 225 QQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 273
++H Y G W + VA+KTLK TM E FL+EA +MK++KH LVQ
Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 331
Query: 274 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 332
L V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E+ N+I
Sbjct: 332 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 391
Query: 333 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 392
HRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+IKS
Sbjct: 392 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 451
Query: 393 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 452
DVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM CWK P
Sbjct: 452 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 511
Query: 453 EERPTFEYLQSFLEDYFTATEPQYQPGENL 482
+RP+F E F + + E L
Sbjct: 512 ADRPSFAETHQAFETMFHDSSISEEVAEEL 541
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 295 bits (754), Expect = 8e-80
Identities = 178/450 (39%), Positives = 246/450 (54%), Gaps = 57/450 (12%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKG-----------AYSLSIRDWD 193
+ WY G + R AE L S N G+FL+RESE++ G Y I
Sbjct: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226
Query: 194 DMK----------------------GDHVK---HYKIRKLDNGGYY----ITTRAQFETL 224
D K D + HY K + Y I + + E
Sbjct: 227 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT 286
Query: 225 QQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 273
++H Y G W + VA+KTLK TM E FL+EA +MK++KH LVQ
Sbjct: 287 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 346
Query: 274 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 332
L V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E+ N+I
Sbjct: 347 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 406
Query: 333 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 392
HRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+IKS
Sbjct: 407 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 466
Query: 393 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 452
DVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM CWK P
Sbjct: 467 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 526
Query: 453 EERPTFEYLQSFLEDYFTATEPQYQPGENL 482
+RP+F E F + + E L
Sbjct: 527 ADRPSFAETHQAFETMFHDSSISEEVAEEL 556
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 295 bits (754), Expect = 8e-80
Identities = 178/450 (39%), Positives = 246/450 (54%), Gaps = 57/450 (12%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKG-----------AYSLSIRDWD 193
+ WY G + R AE L S N G+FL+RESE++ G Y I
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 194 DMK----------------------GDHVK---HYKIRKLDNGGYY----ITTRAQFETL 224
D K D + HY K + Y I + + E
Sbjct: 212 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT 271
Query: 225 QQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 273
++H Y G W + VA+KTLK TM E FL+EA +MK++KH LVQ
Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 331
Query: 274 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 332
L V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E+ N+I
Sbjct: 332 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 391
Query: 333 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 392
HRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+IKS
Sbjct: 392 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 451
Query: 393 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 452
DVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM CWK P
Sbjct: 452 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 511
Query: 453 EERPTFEYLQSFLEDYFTATEPQYQPGENL 482
+RP+F E F + + E L
Sbjct: 512 ADRPSFAETHQAFETMFHDSSISEEVAEEL 541
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 295 bits (754), Expect = 8e-80
Identities = 178/450 (39%), Positives = 246/450 (54%), Gaps = 57/450 (12%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 75 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 132
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKG-----------AYSLSIRDWD 193
+ WY G + R AE L S N G+FL+RESE++ G Y I
Sbjct: 133 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 190
Query: 194 DMK----------------------GDHVK---HYKIRKLDNGGYY----ITTRAQFETL 224
D K D + HY K + Y I + + E
Sbjct: 191 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT 250
Query: 225 QQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 273
++H Y G W + VA+KTLK TM E FL+EA +MK++KH LVQ
Sbjct: 251 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 310
Query: 274 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 332
L V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E+ N+I
Sbjct: 311 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 370
Query: 333 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 392
HRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+IKS
Sbjct: 371 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 430
Query: 393 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 452
DVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM CWK P
Sbjct: 431 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 490
Query: 453 EERPTFEYLQSFLEDYFTATEPQYQPGENL 482
+RP+F E F + + E L
Sbjct: 491 ADRPSFAETHQAFETMFHDSSISEEVAEEL 520
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 294 bits (753), Expect = 1e-79
Identities = 176/437 (40%), Positives = 242/437 (55%), Gaps = 57/437 (13%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 90 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 147
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKG-----------AYSLSIRDWD 193
+ WY G + R AE L S N G+FL+RESE++ G Y I
Sbjct: 148 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 205
Query: 194 DMK----------------------GDHVK---HYKIRKLDNGGYY----ITTRAQFETL 224
D K D + HY K + Y I + + E
Sbjct: 206 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT 265
Query: 225 QQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 273
++H Y G W + VA+KTLK TM E FL+EA +MK++KH LVQ
Sbjct: 266 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 325
Query: 274 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 332
L V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E+ N+I
Sbjct: 326 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 385
Query: 333 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 392
HRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+IKS
Sbjct: 386 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 445
Query: 393 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 452
DVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM CWK P
Sbjct: 446 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 505
Query: 453 EERPTFEYLQSFLEDYF 469
+RP+F E F
Sbjct: 506 ADRPSFAETHQAFETMF 522
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 280 bits (716), Expect = 2e-75
Identities = 155/432 (35%), Positives = 240/432 (55%), Gaps = 63/432 (14%)
Query: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAP--VDSIQA 146
ALYD+ R +L+ + E++ IL WW+AR G G IPSNYV + +++
Sbjct: 89 ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
Query: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKHYKI 205
EWY + R AE LL + G F++R+S G+Y++S+ + +KHY+I
Sbjct: 148 YEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQI 205
Query: 206 RKLDNGGYYITTRAQFETLQQLV---QH-------------------------------- 230
+K D+G +Y+ R F+++ +L+ QH
Sbjct: 206 KKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWE 265
Query: 231 --------------------YSGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 270
+ G W + +VAIK + G+MS E F+EEA++M KL H K
Sbjct: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSK 325
Query: 271 LVQLYAV-VSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 329
LVQLY V + +P+YIVTE+M G LL++L++ +G+ L+ L+ + + GM Y+ER
Sbjct: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERN 384
Query: 330 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 389
YIHRDL + N LV + I KI+DFG+ R + D+EY + GAKFPIKW+ PE L+ +++
Sbjct: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444
Query: 390 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 449
KSDVWSFG+L+ E+ T+G++P+ +N +V+E + G+R+ P P+S++E+M CW
Sbjct: 445 SKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504
Query: 450 KDPEERPTFEYL 461
+ PE RPTF L
Sbjct: 505 EKPEGRPTFAEL 516
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 270 bits (690), Expect = 2e-72
Identities = 150/439 (34%), Positives = 236/439 (53%), Gaps = 66/439 (15%)
Query: 85 TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--D 142
T+ +ALYDY+ +L+ + E++ +L+SSE WW + G GY+PS+Y+ +
Sbjct: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
Query: 143 SIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH--V 200
+++ EWY + R AE+ LL G G F++R+S T G Y++S+ + ++ +
Sbjct: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
Query: 201 KHYKIRKLDNGG--YYITTRAQFETLQQLV---QH------------------------- 230
KHY I++ ++ YY+ + F+++ L+ QH
Sbjct: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
Query: 231 ---------------------------YSGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 263
+ G W KVAIKT++ G MS E F+EEA++M
Sbjct: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
Query: 264 KKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 322
KL H KLVQLY V E+ PI +V E+M G L D+L+ G L+ M V G
Sbjct: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRG-LFAAETLLGMCLDVCEG 469
Query: 323 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 382
MAY+E IHRDL + N LVG + K++DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
Query: 383 ALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE 442
+ R++ KSDVWSFG+L+ E+ ++G++PY +N EV+E + G+R+ P+ +++
Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
Query: 443 LMIHCWKKDPEERPTFEYL 461
+M HCWK+ PE+RP F L
Sbjct: 590 IMNHCWKERPEDRPAFSRL 608
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 270 bits (689), Expect = 3e-72
Identities = 154/439 (35%), Positives = 233/439 (53%), Gaps = 64/439 (14%)
Query: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV-DSIQA 146
VALYDY +DL KG+++ IL S WW AR G+ GYIPSNYV DSI+
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEM 278
Query: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSI--RDWDDMKGDHVKHYK 204
EWY + R AE QLL G F++R+S G Y++S+ + D +G ++HY
Sbjct: 279 YEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSVFAKSTGDPQGV-IRHYV 335
Query: 205 IRKLDNGGYYITTRAQFETLQQLV---QHYS----------------------------- 232
+ YY+ + F T+ +L+ QH S
Sbjct: 336 VCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSW 395
Query: 233 -----------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHD 269
G W G VAIK +K G+MS + F+EEA++M L H+
Sbjct: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE 455
Query: 270 KLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 328
KLVQLY V +++ PI+I+TEYM G LL++L++ R + L++M V M Y+E
Sbjct: 456 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLES 514
Query: 329 MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 388
++HRDL + N LV + + K++DFGL+R + D+EYT+ G+KFP++W+ PE +Y +F
Sbjct: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
Query: 389 TIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCW 448
+ KSD+W+FG+L+ E+ + G++PY N E E + +G R+ P ++ +M CW
Sbjct: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCW 634
Query: 449 KKDPEERPTFEYLQSFLED 467
+ +ERPTF+ L S + D
Sbjct: 635 HEKADERPTFKILLSNILD 653
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 225 bits (574), Expect = 6e-59
Identities = 110/242 (45%), Positives = 159/242 (65%), Gaps = 2/242 (0%)
Query: 233 GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMN 291
G W KVAIK ++ G M E F+EEA++M KL H KLVQLY V +++ PIYIVTE+M
Sbjct: 387 GKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFME 446
Query: 292 KGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKI 351
+G LL+FL+ +G + L+ M V GM Y+ER ++IHRDL + N LV + K+
Sbjct: 447 RGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKV 505
Query: 352 ADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 411
+DFG+AR + D++YT+ GAKFP+KW PE Y RF+ KSDVWSFG+L+ E+ T+GR+P
Sbjct: 506 SDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMP 565
Query: 412 YPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTA 471
+ N EV+ V RG+R+ P+ ++E+M+ CW++ PE RP+FE L +++
Sbjct: 566 FEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVEC 625
Query: 472 TE 473
E
Sbjct: 626 EE 627
Score = 77.4 bits (189), Expect = 3e-14
Identities = 46/151 (30%), Positives = 82/151 (54%), Gaps = 8/151 (5%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVA--PVDS 143
+ VA+YD++A DL +G+++ IL ++ WW AR G GYIPSNYV ++
Sbjct: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
Query: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKH 202
+ EWY + R AE QLL + G F++R+S + G Y++S+ +G +H
Sbjct: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
Query: 203 YKIRKLDNG--GYYITTRAQFETLQQLVQHY 231
Y I++ YY+ + F ++ ++++++
Sbjct: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYH 330
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 224 bits (572), Expect = 1e-58
Identities = 147/437 (33%), Positives = 221/437 (50%), Gaps = 68/437 (15%)
Query: 88 VALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSIQA 146
+A Y++ E DL F KG+ I+ + + +W++A++ G G IP+NYV + ++A
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKREGVKA 73
Query: 147 EE------WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV 200
W+ GK+ R+ AER L + G FL+RES G Y+L + D K +H
Sbjct: 74 GTKLSLMPWFHGKITREQAERLL--YPPETGLFLVRESTNYPGDYTLCVSC--DGKVEHY 129
Query: 201 K---HYKIRKLDNGGYY---------------------ITTRAQFETLQQLVQHYSGTWN 236
+ H +D Y+ I + T+ + Y W
Sbjct: 130 RIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWA 189
Query: 237 GN-------------------------TKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKL 271
N KVA+K +K + ++FL EA +M +L+H L
Sbjct: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK-NDATAQAFLAEASVMTQLRHSNL 248
Query: 272 VQLYAVVSEEP--IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 329
VQL V+ EE +YIVTEYM KGSL+D+L+ L L+ + V M Y+E
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 330 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 389
N++HRDL + N+LV + K++DFGL + + T K P+KWTAPEA +F+
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
Query: 390 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 449
KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++E+M +CW
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
Query: 450 KDPEERPTFEYLQSFLE 466
D RP+F L+ LE
Sbjct: 425 LDAAMRPSFLQLREQLE 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,101,035
Number of Sequences: 37866
Number of extensions: 866638
Number of successful extensions: 4353
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 794
Number of HSP's successfully gapped in prelim test: 285
Number of HSP's that attempted gapping in prelim test: 2045
Number of HSP's gapped (non-prelim): 1384
length of query: 482
length of database: 18,247,518
effective HSP length: 106
effective length of query: 376
effective length of database: 14,233,722
effective search space: 5351879472
effective search space used: 5351879472
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.