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Search of human proteins with 23510362
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23510362 protein-tyrosine kinase fyn isoform b [Homo
sapiens]
(534 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 1102 0.0
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 1038 0.0
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 971 0.0
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 813 0.0
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 774 0.0
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 774 0.0
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 774 0.0
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 763 0.0
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 763 0.0
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 608 e-174
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 570 e-162
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 570 e-162
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 569 e-162
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 569 e-162
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 558 e-159
gi|4503787 fyn-related kinase [Homo sapiens] 460 e-129
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 371 e-102
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 371 e-102
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 371 e-102
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 371 e-102
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 370 e-102
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 363 e-100
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 362 e-100
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 362 e-100
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 348 5e-96
gi|148596974 TXK tyrosine kinase [Homo sapiens] 332 4e-91
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 320 3e-87
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 315 7e-86
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 310 2e-84
gi|187475373 c-src tyrosine kinase [Homo sapiens] 278 9e-75
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 1102 bits (2850), Expect = 0.0
Identities = 534/534 (100%), Positives = 534/534 (100%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
Query: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
Sbjct: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCF 240
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCF
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCF 240
Query: 241 NLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKP 300
NLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKP
Sbjct: 241 NLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKP 300
Query: 301 GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK 360
GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK
Sbjct: 301 GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK 360
Query: 361 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR 420
LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR
Sbjct: 361 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR 420
Query: 421 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY 480
QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY
Sbjct: 421 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY 480
Query: 481 RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Sbjct: 481 RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 1038 bits (2684), Expect = 0.0
Identities = 507/537 (94%), Positives = 514/537 (95%), Gaps = 3/537 (0%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
Query: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
Sbjct: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCF 240
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSE+A GLC
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC 240
Query: 241 NLTVIASSCTPQTSGLA---KDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKT 297
L V P+ + L+ KD WE+ R SL L K+LG G F EVW+GTWNGNTKVAIKT
Sbjct: 241 RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT 300
Query: 298 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 357
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
Sbjct: 301 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 360
Query: 358 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 417
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
Sbjct: 361 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 420
Query: 418 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 477
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
Sbjct: 421 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 480
Query: 478 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Sbjct: 481 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 971 bits (2509), Expect = 0.0
Identities = 482/534 (90%), Positives = 482/534 (90%), Gaps = 52/534 (9%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
Sbjct: 1 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG 60
Query: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
Sbjct: 61 LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCF 240
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS-------- 232
Query: 241 NLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKP 300
GTWNGNTKVAIKTLKP
Sbjct: 233 --------------------------------------------GTWNGNTKVAIKTLKP 248
Query: 301 GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK 360
GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK
Sbjct: 249 GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK 308
Query: 361 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR 420
LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR
Sbjct: 309 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR 368
Query: 421 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY 480
QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY
Sbjct: 369 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY 428
Query: 481 RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Sbjct: 429 RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 482
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 813 bits (2100), Expect = 0.0
Identities = 401/543 (73%), Positives = 448/543 (82%), Gaps = 9/543 (1%)
Query: 1 MGCVQCKDKE--ATKLTEERDGSLNQSSGYRYGTDPT-----PQHYPSFGVTSIPNYNNF 53
MGC++ K+ + A K E +S YG +PT P + + +
Sbjct: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
Query: 54 HAAGGQGLTVFGGVNSSSHTGTLRTRGGT--GVTLFVALYDYEARTEDDLSFHKGEKFQI 111
G G+T FGG +SS G GVT+FVALYDYEART +DLSF KGE+FQI
Sbjct: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
Query: 112 LNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRG 171
+N++EGDWWEARS+ TG+ GYIPSNYVAP DSIQAEEWYFGK+GRKDAER LL+ GN RG
Sbjct: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
Query: 172 TFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY 231
FL+RESETTKGAYSLSIRDWD+++GD+VKHYKIRKLDNGGYYITTRAQF+TLQ+LV+HY
Sbjct: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
Query: 232 SEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNT 291
+E ADGLC LT + + PQT GLAKDAWE+ R SL LE KLGQGCF EVW+GTWNG T
Sbjct: 241 TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 300
Query: 292 KVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFL 351
KVAIKTLKPGTM PE+FL+EAQIMKKL+HDKLV LYAVVSEEPIYIVTE+M+KGSLLDFL
Sbjct: 301 KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 360
Query: 352 KDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARL 411
K+G+G+ LKLP LVDMAAQ+A GMAYIERMNYIHRDLR+ANILVG L+CKIADFGLARL
Sbjct: 361 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL 420
Query: 412 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE 471
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL TELVTKGRVPYPGM NRE
Sbjct: 421 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 480
Query: 472 VLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPG 531
VLEQVERGYRMPCPQ CP SLHELM CWKKDP+ERPTFEY+QSFLEDYFTATEPQYQPG
Sbjct: 481 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 540
Query: 532 ENL 534
ENL
Sbjct: 541 ENL 543
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 774 bits (1998), Expect = 0.0
Identities = 383/537 (71%), Positives = 433/537 (80%), Gaps = 15/537 (2%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56
MGCV CK E +E G Y YG DPT P+ IPNY+NF +
Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
Query: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115
+N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
Query: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175
EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
Query: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKA 235
RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY E
Sbjct: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
Query: 236 DGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAI 295
DGLC L + PQT GLAKDAWE++R S+ LE++LG GCF +VWLGTWNG+TKVA+
Sbjct: 231 DGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAV 290
Query: 296 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE 355
KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK+ E
Sbjct: 291 KTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPE 350
Query: 356 GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN 415
G+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI+D+
Sbjct: 351 GQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD 410
Query: 416 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 475
EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REVLEQ
Sbjct: 411 EYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470
Query: 476 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 532
VE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 774 bits (1998), Expect = 0.0
Identities = 383/537 (71%), Positives = 433/537 (80%), Gaps = 15/537 (2%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56
MGCV CK E +E G Y YG DPT P+ IPNY+NF +
Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
Query: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115
+N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
Query: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175
EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
Query: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKA 235
RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY E
Sbjct: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
Query: 236 DGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAI 295
DGLC L + PQT GLAKDAWE++R S+ LE++LG GCF +VWLGTWNG+TKVA+
Sbjct: 231 DGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAV 290
Query: 296 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE 355
KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK+ E
Sbjct: 291 KTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPE 350
Query: 356 GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN 415
G+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI+D+
Sbjct: 351 GQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD 410
Query: 416 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 475
EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REVLEQ
Sbjct: 411 EYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470
Query: 476 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 532
VE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 774 bits (1998), Expect = 0.0
Identities = 383/537 (71%), Positives = 433/537 (80%), Gaps = 15/537 (2%)
Query: 1 MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56
MGCV CK E +E G Y YG DPT P+ IPNY+NF +
Sbjct: 1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
Query: 57 GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115
+N +GT+R G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 60 A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
Query: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175
EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
Query: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKA 235
RESETTKGAYSLSIRDWD +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY E
Sbjct: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
Query: 236 DGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAI 295
DGLC L + PQT GLAKDAWE++R S+ LE++LG GCF +VWLGTWNG+TKVA+
Sbjct: 231 DGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAV 290
Query: 296 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE 355
KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M GSLLDFLK+ E
Sbjct: 291 KTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPE 350
Query: 356 GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN 415
G+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG L CKIADFGLARLI+D+
Sbjct: 351 GQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD 410
Query: 416 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 475
EY QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REVLEQ
Sbjct: 411 EYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470
Query: 476 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 532
VE+GY MPCP CP SL+E M W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 763 bits (1970), Expect = 0.0
Identities = 366/475 (77%), Positives = 417/475 (87%), Gaps = 4/475 (0%)
Query: 63 VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119
+FGG NSS T T R G GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63 LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
Query: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+ NPRGTFL+RESE
Sbjct: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
Query: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLC 239
TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS+ ADGLC
Sbjct: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
Query: 240 FNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLK 299
LT + + PQT GLAKDAWE+ R SL LE KLGQGCF EVW+GTWNG T+VAIKTLK
Sbjct: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 301
Query: 300 PGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRAL 359
PGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G+ L
Sbjct: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361
Query: 360 KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTA 419
+LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNEYTA
Sbjct: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421
Query: 420 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG 479
RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QVERG
Sbjct: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481
Query: 480 YRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
YRMPCP +CP SLH+LM CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 763 bits (1970), Expect = 0.0
Identities = 366/475 (77%), Positives = 417/475 (87%), Gaps = 4/475 (0%)
Query: 63 VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119
+FGG NSS T T R G GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63 LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
Query: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+ NPRGTFL+RESE
Sbjct: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
Query: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLC 239
TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS+ ADGLC
Sbjct: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
Query: 240 FNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLK 299
LT + + PQT GLAKDAWE+ R SL LE KLGQGCF EVW+GTWNG T+VAIKTLK
Sbjct: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 301
Query: 300 PGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRAL 359
PGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G+ L
Sbjct: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361
Query: 360 KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTA 419
+LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNEYTA
Sbjct: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421
Query: 420 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG 479
RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QVERG
Sbjct: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481
Query: 480 YRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
YRMPCP +CP SLH+LM CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 608 bits (1568), Expect = e-174
Identities = 299/469 (63%), Positives = 370/469 (78%), Gaps = 4/469 (0%)
Query: 62 TVFGGVNS-SSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120
T+ G NS +S+T +R G + + VALYDYEA +DLSF KG++ +L S G+WW
Sbjct: 58 TIKPGPNSHNSNTPGIREAGSEDI-IVVALYDYEAIHHEDLSFQKGDQMVVLEES-GEWW 115
Query: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180
+ARSL T + GYIPSNYVA VDS++ EEW+F + RKDAERQLL+ GN G+F+IR+SET
Sbjct: 116 KARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSET 175
Query: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCF 240
TKG+YSLS+RD+D +GD VKHYKIR LDNGG+YI+ R+ F TLQ+LV HY + DGLC
Sbjct: 176 TKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQ 235
Query: 241 NLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKP 300
L+V S PQ KDAWE+ R SL LEKKLG G F EVW+ T+N +TKVA+KT+KP
Sbjct: 236 KLSVPCMSSKPQKPW-EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKP 294
Query: 301 GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK 360
G+MS E+FL EA +MK L+HDKLV+L+AVV++EPIYI+TE+M KGSLLDFLK EG
Sbjct: 295 GSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQP 354
Query: 361 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR 420
LP L+D +AQ+A GMA+IE+ NYIHRDLR+ANILV L+CKIADFGLAR+IEDNEYTAR
Sbjct: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414
Query: 421 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY 480
+GAKFPIKWTAPEA +G FTIKSDVWSFGILL E+VT GR+PYPGM+N EV+ +ERGY
Sbjct: 415 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 474
Query: 481 RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQ 529
RMP P++CP L+ +M+ CWK PEERPTFEY+QS L+D++TATE QYQ
Sbjct: 475 RMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQ 523
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 570 bits (1468), Expect = e-162
Identities = 276/445 (62%), Positives = 347/445 (77%), Gaps = 3/445 (0%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
+ VALY Y+ DDLSF KGEK ++L G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
EEW+F + RKDAERQLL+ GN G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVAR 265
R LDNGGYYI+ R F + +++HY ++ADGLC L S PQ KDAWE+ R
Sbjct: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPW-DKDAWEIPR 223
Query: 266 RSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 325
S+ L K+LG G F EVW+G +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDKLV+
Sbjct: 224 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 283
Query: 326 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 384
LYAVV+ EEPIYI+TEYM KGSLLDFLK EG + LP L+D +AQ+A GMAYIER NYI
Sbjct: 284 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 343
Query: 385 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 444
HRDLR+AN+LV L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKS
Sbjct: 344 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 403
Query: 445 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 504
DVWSFGILL E+VT G++PYPG N +V+ + +GYRMP ++CP L+++M CWK+
Sbjct: 404 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 463
Query: 505 EERPTFEYLQSFLEDYFTATEPQYQ 529
EERPTF+YLQS L+D++TATE QYQ
Sbjct: 464 EERPTFDYLQSVLDDFYTATEGQYQ 488
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 570 bits (1468), Expect = e-162
Identities = 276/445 (62%), Positives = 347/445 (77%), Gaps = 3/445 (0%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
+ VALY Y+ DDLSF KGEK ++L G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 67 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
EEW+F + RKDAERQLL+ GN G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVAR 265
R LDNGGYYI+ R F + +++HY ++ADGLC L S PQ KDAWE+ R
Sbjct: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPW-DKDAWEIPR 244
Query: 266 RSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 325
S+ L K+LG G F EVW+G +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDKLV+
Sbjct: 245 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 304
Query: 326 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 384
LYAVV+ EEPIYI+TEYM KGSLLDFLK EG + LP L+D +AQ+A GMAYIER NYI
Sbjct: 305 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364
Query: 385 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 444
HRDLR+AN+LV L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKS
Sbjct: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424
Query: 445 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 504
DVWSFGILL E+VT G++PYPG N +V+ + +GYRMP ++CP L+++M CWK+
Sbjct: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 484
Query: 505 EERPTFEYLQSFLEDYFTATEPQYQ 529
EERPTF+YLQS L+D++TATE QYQ
Sbjct: 485 EERPTFDYLQSVLDDFYTATEGQYQ 509
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 569 bits (1466), Expect = e-162
Identities = 276/445 (62%), Positives = 349/445 (78%), Gaps = 2/445 (0%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
L +AL+ YE + DL F KGE+ +IL S G+WW+A+SLTTG+ G+IP N+VA +S++
Sbjct: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
E W+F L RKDAERQLL+ GN G+FLIRESE+T G++SLS+RD+D +G+ VKHYKI
Sbjct: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVAR 265
R LDNGG+YI+ R F L +LV+HY+ +DGLC L+ + PQ +D WEV R
Sbjct: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW-EDEWEVPR 242
Query: 266 RSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 325
+L L ++LG G F EVW+G +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +LV+
Sbjct: 243 ETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVR 302
Query: 326 LYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 385
LYAVV++EPIYI+TEYM GSL+DFLK G L + L+DMAAQ+A GMA+IE NYIH
Sbjct: 303 LYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIH 362
Query: 386 RDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 445
RDLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTIKSD
Sbjct: 363 RDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSD 422
Query: 446 VWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE 505
VWSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM P +CP L++LM CWK+ PE
Sbjct: 423 VWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPE 482
Query: 506 ERPTFEYLQSFLEDYFTATEPQYQP 530
+RPTF+YL+S LED+FTATE QYQP
Sbjct: 483 DRPTFDYLRSVLEDFFTATEGQYQP 507
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 569 bits (1466), Expect = e-162
Identities = 276/445 (62%), Positives = 349/445 (78%), Gaps = 2/445 (0%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
L +AL+ YE + DL F KGE+ +IL S G+WW+A+SLTTG+ G+IP N+VA +S++
Sbjct: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
Query: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
E W+F L RKDAERQLL+ GN G+FLIRESE+T G++SLS+RD+D +G+ VKHYKI
Sbjct: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVAR 265
R LDNGG+YI+ R F L +LV+HY+ +DGLC L+ + PQ +D WEV R
Sbjct: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW-EDEWEVPR 242
Query: 266 RSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 325
+L L ++LG G F EVW+G +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +LV+
Sbjct: 243 ETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVR 302
Query: 326 LYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 385
LYAVV++EPIYI+TEYM GSL+DFLK G L + L+DMAAQ+A GMA+IE NYIH
Sbjct: 303 LYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIH 362
Query: 386 RDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 445
RDLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTIKSD
Sbjct: 363 RDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSD 422
Query: 446 VWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE 505
VWSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM P +CP L++LM CWK+ PE
Sbjct: 423 VWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPE 482
Query: 506 ERPTFEYLQSFLEDYFTATEPQYQP 530
+RPTF+YL+S LED+FTATE QYQP
Sbjct: 483 DRPTFDYLRSVLEDFFTATEGQYQP 507
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 558 bits (1438), Expect = e-159
Identities = 281/443 (63%), Positives = 341/443 (76%), Gaps = 5/443 (1%)
Query: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
VALYDY A + DL KGEK Q+L + GDWW ARSL TG GY+PSN+VA V+S++ E
Sbjct: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
Query: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
W+F GRK+AERQLL+ N G+FLIRESET KGA+SLS++D +G+ +KHYKIR
Sbjct: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
Query: 208 LDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRS 267
LD GGYYI+ R F +LQ LVQHYS+K DGLC LT+ PQ A+D WE+ R+S
Sbjct: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
Query: 268 LCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY 327
L L +KLG G F EVW+G + N KVAIKTLK GTMSPE+FL EA +MK L+H++LV+LY
Sbjct: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
Query: 328 AVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRD 387
AVV++EPIYIVTEYM +G LLDFLK EG L LP L+DM+AQ+A GMAYIERMN IHRD
Sbjct: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
Query: 388 LRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 447
LR+ANILV L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+DVW
Sbjct: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
Query: 448 SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKDPEE 506
SFG+LL E+VT GRVPYPGM+N EV+ +ERGYRMP P CP L+ ++ CW+ PEE
Sbjct: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
Query: 507 RPTFEYLQSFLEDYFTATEPQYQ 529
RPTFE+LQS LED++TATE QY+
Sbjct: 480 RPTFEFLQSVLEDFYTATERQYE 502
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 460 bits (1183), Expect = e-129
Identities = 238/462 (51%), Positives = 307/462 (66%), Gaps = 21/462 (4%)
Query: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETG-------YIPSNYVA 139
FVAL+DY+ART +DLSF G+K Q+L++ WW AR L G YIPSNYVA
Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
Query: 140 PVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH 199
S+QAE W+FG +GR DAE+QLL N G+FLIRESE+ KG +SLS+ D G
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
Query: 200 VKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNL----TVIASSCTPQTSG 255
VKHY+I++LD GG+++T R F TL + V HY++ +DGLC L I S
Sbjct: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
Query: 256 LAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 315
D WE+ R S+ L K+LG G F EVW G WN T VA+KTLKPG+M P FL EAQIM
Sbjct: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
Query: 316 KKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 374
K L+H KL+QLYAV + E+PIYI+TE M GSL ++L++ G + L VDMAAQVA+G
Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
Query: 375 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE-DNE--YTARQGAKFPIKWTA 431
MAY+E NYIHRDL + N+LVG I K+ADFGLAR+ + DNE Y +R K P+KWTA
Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
Query: 432 PEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPIS 491
PEA +F+IKSDVWSFGILL E++T G++PY GM +V++ + + YR+P P +CP
Sbjct: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
Query: 492 LHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGEN 533
+ +M+ CW +P+ERPTFE L+ LEDYF T+ Y N
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 371 bits (952), Expect = e-102
Identities = 201/455 (44%), Positives = 281/455 (61%), Gaps = 15/455 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 206
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261
I +G Y+T ++F TL +LV H+S ADGL L A C P G++ D W
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 266
Query: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320
E+ R + ++ KLG G + EV++G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
Query: 321 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379
LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
Query: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
Query: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM C
Sbjct: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
Query: 500 WKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
WK P +RP+F E F + + E L
Sbjct: 507 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 371 bits (952), Expect = e-102
Identities = 201/455 (44%), Positives = 281/455 (61%), Gaps = 15/455 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 221
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261
I +G Y+T ++F TL +LV H+S ADGL L A C P G++ D W
Sbjct: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 281
Query: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320
E+ R + ++ KLG G + EV++G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
Query: 321 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379
LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E
Sbjct: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
Query: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
Query: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM C
Sbjct: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
Query: 500 WKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
WK P +RP+F E F + + E L
Sbjct: 522 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 371 bits (952), Expect = e-102
Identities = 201/455 (44%), Positives = 281/455 (61%), Gaps = 15/455 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 206
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261
I +G Y+T ++F TL +LV H+S ADGL L A C P G++ D W
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 266
Query: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320
E+ R + ++ KLG G + EV++G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
Query: 321 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379
LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
Query: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
Query: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM C
Sbjct: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
Query: 500 WKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
WK P +RP+F E F + + E L
Sbjct: 507 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 371 bits (952), Expect = e-102
Identities = 201/455 (44%), Positives = 281/455 (61%), Gaps = 15/455 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 75 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 132
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 133 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 185
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261
I +G Y+T ++F TL +LV H+S ADGL L A C P G++ D W
Sbjct: 186 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 245
Query: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320
E+ R + ++ KLG G + EV++G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 246 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 305
Query: 321 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379
LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E
Sbjct: 306 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 365
Query: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 366 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 425
Query: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM C
Sbjct: 426 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 485
Query: 500 WKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
WK P +RP+F E F + + E L
Sbjct: 486 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 520
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 370 bits (951), Expect = e-102
Identities = 199/442 (45%), Positives = 277/442 (62%), Gaps = 15/442 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 90 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 147
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 148 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 200
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261
I +G Y+T ++F TL +LV H+S ADGL L A C P G++ D W
Sbjct: 201 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 260
Query: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320
E+ R + ++ KLG G + EV++G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 320
Query: 321 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379
LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E
Sbjct: 321 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 380
Query: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 381 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 440
Query: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM C
Sbjct: 441 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 500
Query: 500 WKKDPEERPTFEYLQSFLEDYF 521
WK P +RP+F E F
Sbjct: 501 WKWSPADRPSFAETHQAFETMF 522
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 363 bits (933), Expect = e-100
Identities = 191/446 (42%), Positives = 272/446 (60%), Gaps = 14/446 (3%)
Query: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGET---GYIPSNYVAPVDS 143
+V L+D+++RT+++LSF G+ F + E WW G GY+P NY+A ++
Sbjct: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
Query: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
+++E W+FG + R +A R+L + GN G FLIR SE Y LS+RD V+HY
Sbjct: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
Query: 204 KIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAK-DAWE 262
KI + G ++ F +L +LV ++ +A L L + A + L D WE
Sbjct: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYH--RAQSLSHGLRLAAPCRKHEPEPLPHWDDWE 185
Query: 263 VARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLE-EAQIMKKLKHD 321
R L +KLG G F EV+ G W +VAIK + + + L+ E Q MKKL+H
Sbjct: 186 RPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHK 245
Query: 322 KLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 380
++ LYAVVS +P+YI+TE M KGSLL+ L+D + + L + L+D+A QVA GM Y+E
Sbjct: 246 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 305
Query: 381 MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 440
NYIHRDL + NILVG +CK+ DFGLARLI+++ Y + P KWTAPEA G +
Sbjct: 306 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHY 364
Query: 441 TIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCW 500
+ KSDVWSFGILL E+ ++G+VPYPGM+N E +V+ GYRMPCP +CP S+H+LM+ CW
Sbjct: 365 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCW 424
Query: 501 KKDPEERPTFEYLQSFLEDYFTATEP 526
+DPE+RP F+ L+ L + + P
Sbjct: 425 CRDPEQRPCFKALRERLSSFTSYENP 450
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 362 bits (930), Expect = e-100
Identities = 194/442 (43%), Positives = 279/442 (63%), Gaps = 15/442 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L + G+W EA+ T G++PSNY+ PV+S+
Sbjct: 65 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSL 122
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 123 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 175
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261
I +G Y+++ ++F TL +LV H+S ADGL L A P G++ D W
Sbjct: 176 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 235
Query: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320
E+ R + ++ KLG G + EV+ G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 236 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 295
Query: 321 DKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379
LVQL V + EP YI+TE+M G+LLD+L++ + + L+ MA Q+++ M Y+E
Sbjct: 296 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 355
Query: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y +
Sbjct: 356 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 415
Query: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
F+IKSDVW+FG+LL E+ T G PYPG++ +V E +E+ YRM P+ CP ++ELM C
Sbjct: 416 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 475
Query: 500 WKKDPEERPTFEYLQSFLEDYF 521
W+ +P +RP+F + E F
Sbjct: 476 WQWNPSDRPSFAEIHQAFETMF 497
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 362 bits (930), Expect = e-100
Identities = 194/442 (43%), Positives = 279/442 (63%), Gaps = 15/442 (3%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144
LFVALYD+ A ++ LS KGEK ++L + G+W EA+ T G++PSNY+ PV+S+
Sbjct: 84 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSL 141
Query: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 142 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 194
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261
I +G Y+++ ++F TL +LV H+S ADGL L A P G++ D W
Sbjct: 195 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 254
Query: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320
E+ R + ++ KLG G + EV+ G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 255 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 314
Query: 321 DKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379
LVQL V + EP YI+TE+M G+LLD+L++ + + L+ MA Q+++ M Y+E
Sbjct: 315 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 374
Query: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y +
Sbjct: 375 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 434
Query: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
F+IKSDVW+FG+LL E+ T G PYPG++ +V E +E+ YRM P+ CP ++ELM C
Sbjct: 435 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 494
Query: 500 WKKDPEERPTFEYLQSFLEDYF 521
W+ +P +RP+F + E F
Sbjct: 495 WQWNPSDRPSFAEIHQAFETMF 516
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 348 bits (894), Expect = 5e-96
Identities = 188/435 (43%), Positives = 262/435 (60%), Gaps = 12/435 (2%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--DS 143
LF+ALYD+ AR +LS +G++ L G + R G +P +VA ++
Sbjct: 55 LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114
Query: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
+ + WYF + R A++ LLS N G FLIR SE++ G YSLS+R V HY
Sbjct: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVR-----AQAKVCHY 169
Query: 204 KIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEV 263
++ +G Y+ F L++L+ +Y KA+ ++ C PQ + +D WE
Sbjct: 170 RVSMAADGSLYLQKGRLFPGLEELLTYY--KANWKLIQNPLL-QPCMPQKAP-RQDVWER 225
Query: 264 ARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKL 323
L +KLG+G F EVW G W G+ VAIK +K M +E Q +K L+H++L
Sbjct: 226 PHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERL 285
Query: 324 VQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 382
++L+AV S EP+YIVTE M KG+L FL EGRAL+LP L+ A QVA GM+Y+E
Sbjct: 286 IRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQR 345
Query: 383 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 442
+HRDL + N+LV +GL CK+ADFGLARL++D+ Y+ +K P+KWTAPEAA Y F+
Sbjct: 346 VVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQ 405
Query: 443 KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK 502
KSDVWSFG+LL E+ T G+ PY GM N E L+Q+ RGYR+P P CP ++ LM+ CW+
Sbjct: 406 KSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRS 465
Query: 503 DPEERPTFEYLQSFL 517
PEERP+F L+ L
Sbjct: 466 SPEERPSFATLREKL 480
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 332 bits (852), Expect = 4e-91
Identities = 171/432 (39%), Positives = 264/432 (61%), Gaps = 11/432 (2%)
Query: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAP--VDSIQA 146
ALYD+ R +L+ + E++ IL WW+AR G G IPSNYV + +++
Sbjct: 89 ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
Query: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKHYKI 205
EWY + R AE LL + G F++R+S G+Y++S+ + +KHY+I
Sbjct: 148 YEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQI 205
Query: 206 RKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTV---IASSCTPQTSGLAKDAWE 262
+K D+G +Y+ R F+++ +L+ ++ A GL L + SC P T+G + + WE
Sbjct: 206 KKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWE 265
Query: 263 VARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 322
+ L K++G G F V LG W + +VAIK + G+MS E F+EEA++M KL H K
Sbjct: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSK 325
Query: 323 LVQLYAV-VSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 381
LVQLY V + +P+YIVTE+M G LL++L++ +G+ L+ L+ + + GM Y+ER
Sbjct: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERN 384
Query: 382 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 441
YIHRDL + N LV + I KI+DFG+ R + D+EY + GAKFPIKW+ PE L+ +++
Sbjct: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444
Query: 442 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 501
KSDVWSFG+L+ E+ T+G++P+ +N +V+E + G+R+ P P+S++E+M CW
Sbjct: 445 SKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504
Query: 502 KDPEERPTFEYL 513
+ PE RPTF L
Sbjct: 505 EKPEGRPTFAEL 516
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 320 bits (819), Expect = 3e-87
Identities = 173/449 (38%), Positives = 263/449 (58%), Gaps = 13/449 (2%)
Query: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDS-- 143
+ VA+YD++A DL +G+++ IL ++ WW AR G GYIPSNYV S
Sbjct: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
Query: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKH 202
+ EWY + R AE QLL + G F++R+S + G Y++S+ +G +H
Sbjct: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
Query: 203 YKIRKLDNGG--YYITTRAQFETLQQLVQHYSEKADGLCFNLTV---IASSCTPQTSGLA 257
Y I++ YY+ + F ++ ++++++ A GL L + P T+G +
Sbjct: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
Query: 258 KDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKK 317
+ WE+ L ++LG G F V LG W KVAIK ++ G M E F+EEA++M K
Sbjct: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
Query: 318 LKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMA 376
L H KLVQLY V +++ PIYIVTE+M +G LL+FL+ +G + L+ M V GM
Sbjct: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
Query: 377 YIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 436
Y+ER ++IHRDL + N LV + K++DFG+AR + D++YT+ GAKFP+KW PE
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
Query: 437 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELM 496
Y RF+ KSDVWSFG+L+ E+ T+GR+P+ N EV+ V RG+R+ P+ ++E+M
Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
Query: 497 IHCWKKDPEERPTFEYLQSFLEDYFTATE 525
+ CW++ PE RP+FE L +++ E
Sbjct: 599 LRCWQEKPEGRPSFEDLLRTIDELVECEE 627
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 315 bits (807), Expect = 7e-86
Identities = 168/439 (38%), Positives = 255/439 (58%), Gaps = 12/439 (2%)
Query: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV-DSIQA 146
VALYDY +DL KG+++ IL S WW AR G+ GYIPSNYV DSI+
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEM 278
Query: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSI--RDWDDMKGDHVKHYK 204
EWY + R AE QLL G F++R+S G Y++S+ + D +G ++HY
Sbjct: 279 YEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSVFAKSTGDPQGV-IRHYV 335
Query: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT---PQTSGLAKDAW 261
+ YY+ + F T+ +L+ ++ + GL L S P T+GL +W
Sbjct: 336 VCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSW 395
Query: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHD 321
E+ + L K+LG G F V G W G VAIK +K G+MS + F+EEA++M L H+
Sbjct: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE 455
Query: 322 KLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 380
KLVQLY V +++ PI+I+TEYM G LL++L++ R + L++M V M Y+E
Sbjct: 456 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLES 514
Query: 381 MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 440
++HRDL + N LV + + K++DFGL+R + D+EYT+ G+KFP++W+ PE +Y +F
Sbjct: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
Query: 441 TIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCW 500
+ KSD+W+FG+L+ E+ + G++PY N E E + +G R+ P ++ +M CW
Sbjct: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCW 634
Query: 501 KKDPEERPTFEYLQSFLED 519
+ +ERPTF+ L S + D
Sbjct: 635 HEKADERPTFKILLSNILD 653
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 310 bits (795), Expect = 2e-84
Identities = 162/439 (36%), Positives = 254/439 (57%), Gaps = 14/439 (3%)
Query: 85 TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--D 142
T+ +ALYDY+ +L+ + E++ +L+SSE WW + G GY+PS+Y+ +
Sbjct: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
Query: 143 SIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH--V 200
+++ EWY + R AE+ LL G G F++R+S T G Y++S+ + ++ +
Sbjct: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
Query: 201 KHYKIRKLDNGG--YYITTRAQFETLQQLVQHYSEKADGLCFNL---TVIASSCTPQTSG 255
KHY I++ ++ YY+ + F+++ L+ ++ GL L P T+G
Sbjct: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
Query: 256 LAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 315
L W + L +++G G F V LG W KVAIKT++ G MS E F+EEA++M
Sbjct: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
Query: 316 KKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 374
KL H KLVQLY V E+ PI +V E+M G L D+L+ G L+ M V G
Sbjct: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRG-LFAAETLLGMCLDVCEG 469
Query: 375 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 434
MAY+E IHRDL + N LVG + K++DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
Query: 435 ALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE 494
+ R++ KSDVWSFG+L+ E+ ++G++PY +N EV+E + G+R+ P+ +++
Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
Query: 495 LMIHCWKKDPEERPTFEYL 513
+M HCWK+ PE+RP F L
Sbjct: 590 IMNHCWKERPEDRPAFSRL 608
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 278 bits (711), Expect = 9e-75
Identities = 168/443 (37%), Positives = 248/443 (55%), Gaps = 28/443 (6%)
Query: 88 VALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSIQA 146
+A Y++ E DL F KG+ I+ + + +W++A++ G G IP+NYV + ++A
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKREGVKA 73
Query: 147 EE------WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV 200
W+ GK+ R+ AER L + G FL+RES G Y+L + D K +H
Sbjct: 74 GTKLSLMPWFHGKITREQAERLL--YPPETGLFLVRESTNYPGDYTLCVSC--DGKVEHY 129
Query: 201 K-HYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTV--IASSCTPQTSGLA 257
+ Y KL I FE L QLV+HY+ ADGLC L +
Sbjct: 130 RIMYHASKLS-----IDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFY 184
Query: 258 KDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKK 317
+ W + + L L + +G+G F +V LG + GN KVA+K +K + ++FL EA +M +
Sbjct: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQ 242
Query: 318 LKHDKLVQLYAVVSEEP--IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGM 375
L+H LVQL V+ EE +YIVTEYM KGSL+D+L+ L L+ + V M
Sbjct: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302
Query: 376 AYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 435
Y+E N++HRDL + N+LV + K++DFGL + + T K P+KWTAPEA
Sbjct: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEAL 358
Query: 436 LYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHEL 495
+F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++E+
Sbjct: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEV 418
Query: 496 MIHCWKKDPEERPTFEYLQSFLE 518
M +CW D RP+F L+ LE
Sbjct: 419 MKNCWHLDAAMRPSFLQLREQLE 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,263,361
Number of Sequences: 37866
Number of extensions: 962958
Number of successful extensions: 4676
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 794
Number of HSP's successfully gapped in prelim test: 299
Number of HSP's that attempted gapping in prelim test: 2231
Number of HSP's gapped (non-prelim): 1374
length of query: 534
length of database: 18,247,518
effective HSP length: 107
effective length of query: 427
effective length of database: 14,195,856
effective search space: 6061630512
effective search space used: 6061630512
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.