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Search of human proteins with 116089325
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
(624 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 1221 0.0
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 995 0.0
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens] 345 7e-95
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 178 1e-44
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 164 3e-40
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 162 1e-39
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 158 2e-38
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 151 2e-36
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 149 8e-36
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 145 8e-35
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 140 3e-33
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 139 1e-32
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 138 1e-32
gi|169167715 PREDICTED: hypothetical protein [Homo sapiens] 132 1e-30
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 129 8e-30
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 129 8e-30
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 127 4e-29
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 125 2e-28
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s... 119 6e-27
gi|20070262 TNF receptor-associated factor 3 interacting protein... 116 7e-26
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 116 7e-26
gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi... 115 2e-25
gi|213385278 TNF receptor-associated factor 3 interacting protei... 114 4e-25
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 113 5e-25
gi|52426743 cisplatin resistance-associated overexpressed protei... 112 1e-24
gi|19923485 cisplatin resistance-associated overexpressed protei... 112 1e-24
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 111 2e-24
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 110 3e-24
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 110 3e-24
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 107 3e-23
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 1221 bits (3160), Expect = 0.0
Identities = 624/624 (100%), Positives = 624/624 (100%)
Query: 1 MNSGGGFGLGLGFGLTPTSVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAF 60
MNSGGGFGLGLGFGLTPTSVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAF
Sbjct: 1 MNSGGGFGLGLGFGLTPTSVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAF 60
Query: 61 SSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEESKALSLLAPAPTMTSL 120
SSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEESKALSLLAPAPTMTSL
Sbjct: 61 SSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEESKALSLLAPAPTMTSL 120
Query: 121 MPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEI 180
MPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEI
Sbjct: 121 MPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEI 180
Query: 181 RRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALA 240
RRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALA
Sbjct: 181 RRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALA 240
Query: 241 FNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKS 300
FNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKS
Sbjct: 241 FNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKS 300
Query: 301 NERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSK 360
NERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSK
Sbjct: 301 NERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSK 360
Query: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 420
SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE
Sbjct: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 420
Query: 421 REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP 480
REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP
Sbjct: 421 REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP 480
Query: 481 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD 540
PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD
Sbjct: 481 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD 540
Query: 541 HISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600
HISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE
Sbjct: 541 HISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600
Query: 601 ENKIQHNGNCQLNEENLSTKTEAV 624
ENKIQHNGNCQLNEENLSTKTEAV
Sbjct: 601 ENKIQHNGNCQLNEENLSTKTEAV 624
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 995 bits (2573), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 117 MTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSK 176
MTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSK
Sbjct: 1 MTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSK 60
Query: 177 IDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVP 236
IDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVP
Sbjct: 61 IDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVP 120
Query: 237 RALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPE 296
RALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPE
Sbjct: 121 RALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPE 180
Query: 297 SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK 356
SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK
Sbjct: 181 SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK 240
Query: 357 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD 416
KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD
Sbjct: 241 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD 300
Query: 417 RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK 476
RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK
Sbjct: 301 RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK 360
Query: 477 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536
SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE
Sbjct: 361 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 420
Query: 537 KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA 596
KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA
Sbjct: 421 KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA 480
Query: 597 PRTEENKIQHNGNCQLNEENLSTKTEAV 624
PRTEENKIQHNGNCQLNEENLSTKTEAV
Sbjct: 481 PRTEENKIQHNGNCQLNEENLSTKTEAV 508
>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
Length = 484
Score = 345 bits (885), Expect = 7e-95
Identities = 228/551 (41%), Positives = 307/551 (55%), Gaps = 104/551 (18%)
Query: 4 GGGFGLGLGFGLTPTSVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAFSSK 63
GGG G G G G T VIQVTN+S + +SEQMRTLF FLG+I+ELRL+PPD++PL SS+
Sbjct: 21 GGGGGGGGGGG---TEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSR 77
Query: 64 VCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEESKALSLLAPAPTMTSLMPG 123
VC+VKF DP S VAQHLTNTVF+DRALIVVP AEG IP+E+KALSLLAPA + L+PG
Sbjct: 78 VCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPG 137
Query: 124 AGLLPIPTPNPLTTLG-VSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEIRR 182
GLL PTPNPLT +G V L++LG A LDP +A LG L G
Sbjct: 138 GGLL--PTPNPLTQIGAVPLAALG---APTLDPALAALG------LPG------------ 174
Query: 183 TVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFN 242
NLNSQ+ ADQLL+ V
Sbjct: 175 ----ANLNSQSLAADQLLKLMSTVDP---------------------------------- 196
Query: 243 GVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNE 302
K+NH +V P + ++KE+EE MKRVREAQS ISAAIEP+ K +
Sbjct: 197 ---------KLNHVAAGLVS-PSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDK-KEEK 245
Query: 303 RKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSR 362
R+ RSRS +R R + S SR +RS+S+ R RSH++SRS RRRSKSP ++RS SR
Sbjct: 246 RRHSRSRSRSR---RRRTPSSSRHRRSRSRSRRRSHSKSRS----RRRSKSPRRRRSHSR 298
Query: 363 ER-RKSRSRSHSRDKRKDTREKIKEKERVK-----EKDREKEREREKEREKEKERGKNKD 416
ER R+SRS S +RDK+K+ +EK + K K + R RER + R + R K
Sbjct: 299 ERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKP 358
Query: 417 RDKEREKDR-------EKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE 469
R +R+ R +K+K+KD+++ER ++ + +K+K +DKEK+RE+
Sbjct: 359 RSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRER-------- 410
Query: 470 KRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRN 529
K + DK + R Y+ + S +E++ + + SP+T + K + S+
Sbjct: 411 KSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKV 470
Query: 530 KKDKKREKERD 540
D E++ D
Sbjct: 471 NGDDHHEEDMD 481
Score = 148 bits (374), Expect = 1e-35
Identities = 104/308 (33%), Positives = 158/308 (51%), Gaps = 54/308 (17%)
Query: 322 SHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR 381
S S + + SK + R R Q + P KK K RR SRSRS SR +R +
Sbjct: 207 SPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEK---RRHSRSRSRSRRRRTPSS 263
Query: 382 EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER-EREKE 440
+ + R + + R +K R + R K + + RER R +
Sbjct: 264 SR-----------------HRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRS 306
Query: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRR 500
K RDK+KE DKEK K+S+TPP+SY+ +RRSRS+SRERRRR
Sbjct: 307 TSKTRDKKKE---DKEK-----------------KRSKTPPKSYSTARRSRSASRERRRR 346
Query: 501 RSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSND 560
RSRS +RSP+ ++ KRK SRSPSPR R+KK+KK++K+++ R ERERSTS +K S D
Sbjct: 347 RSRSGTRSPKKPRSPKRKLSRSPSPR-RHKKEKKKDKDKER--SRDERERSTSKKKKSKD 403
Query: 561 RD-GKEKLEKNSTSLK---------EKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNC 610
++ +E+ ++ +K E+ ++ E + K+ + +P+T+E ++
Sbjct: 404 KEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGD 463
Query: 611 QLNEENLS 618
L E ++
Sbjct: 464 SLRESKVN 471
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 178 bits (452), Expect = 1e-44
Identities = 104/341 (30%), Positives = 187/341 (54%), Gaps = 48/341 (14%)
Query: 299 KSNERKGGRSRSHTRSKSRSSSKS-HSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKK 357
+ ER+ R R R K R + H R+R + K R R +R R RQ+++ R++ ++
Sbjct: 69 RQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERE 128
Query: 358 RSKSRERRKSRSRS----HSRDKRKDTR---------------EKIKEKERVKEKDREKE 398
R RE + R R R++++D E+ ++KER +EK+R++
Sbjct: 129 RETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQER 188
Query: 399 REREKEREKE-------KERGKNKDRDKE--------REKDREKDKEKDREREREKEHEK 443
RERE++REKE ERG+ ++R++E R+ DRE+D+++ EREREK+ E+
Sbjct: 189 RERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAER 248
Query: 444 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 503
+R E+E E+DKE+ERE+DR ++ D +R+K+++ +T + + R R + R+R R+R R
Sbjct: 249 ERASERETERDKERERERDRDRDRD-RRQKERERQTDRKRQRRTERDRETERKRERQRER 307
Query: 504 SSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER-RERERSTSMRKSSNDRD 562
R + +R+ R +++++RE ERD ER R+R+R T M + N +
Sbjct: 308 ERERERNRKRERERERER--------ERERQRETERDREKERERKRKRQTEMDRERNRQT 359
Query: 563 GKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603
G+E + + +E+E +E D ++E ++++ R + +
Sbjct: 360 GREGRRQ---AERERERERERDRQSAREREERERDRDRDRQ 397
Score = 175 bits (443), Expect = 1e-43
Identities = 94/312 (30%), Positives = 181/312 (58%), Gaps = 23/312 (7%)
Query: 314 SKSRSSSKSHSRRKRSQSKHRSRS-HNRSRSRQKDRRR---SKSPHKKRSKSRERRKSRS 369
S+ R S+ RR+ H+ +R R+RQK+R R + ++ + RERR+ +
Sbjct: 27 SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKD 86
Query: 370 RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD----- 424
R RD+ ++ R++ +EKER ++ DRE++R+REKER ++KER + +R+ ER +D
Sbjct: 87 RHRKRDRHRE-RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDG 145
Query: 425 -REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRS 483
RE+++++D E+ERE++ +++R ++ E+ + KE+EREK+R + + +R+++K+++T R
Sbjct: 146 QRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRH 205
Query: 484 YNASR-----RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKE 538
R R + ER+R+ R R +T + ++++ R + ++DK+RE+E
Sbjct: 206 SERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERE 265
Query: 539 RDHISER----RERERSTS---MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEV 591
RD +R +ERER T R++ DR+ + K E+ +E+E N++ + +E
Sbjct: 266 RDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERER 325
Query: 592 DDKDAPRTEENK 603
+ + TE ++
Sbjct: 326 ERERQRETERDR 337
Score = 172 bits (437), Expect = 6e-43
Identities = 105/370 (28%), Positives = 187/370 (50%), Gaps = 34/370 (9%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQS 331
KE E R R+ Q E E + ER+ R R + R + R R+R
Sbjct: 103 KERERQTDRERDRQR------EKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE 156
Query: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR--EKIKEKER 389
K R R +R R RQ +R R K ++R K+R+ R+ R R ++ + + R E+ +E+ER
Sbjct: 157 KERERQTDRERQRQTERNRQKE--REREKNRQERRERERQREKENKTEDRHSERGRERER 214
Query: 390 VKEKDREKEREREKEREKEKERGKNKDRDKEREKDR--EKDKEKDREREREKEHEKDRD- 446
+E + E ER+R+ +RE++++R ++R+K+ E++R E++ E+D+ERERE++ ++DRD
Sbjct: 215 ERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDR 274
Query: 447 --KEKEK----------EQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS 494
KE+E+ E+D+E ER+++R +E + +R++++K R R +
Sbjct: 275 RQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETE 334
Query: 495 RERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSM 554
R+R + R R R + R++ R ++ +++++RE++R ER ERER
Sbjct: 335 RDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDR 394
Query: 555 -------RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHN 607
R++ DRDG+ + EK K++E + + +E K R E +
Sbjct: 395 DRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRERE-KQKGRERDRERQTDRQ 453
Query: 608 GNCQLNEENL 617
Q L
Sbjct: 454 AGRQRKRSTL 463
Score = 169 bits (427), Expect = 9e-42
Identities = 91/316 (28%), Positives = 172/316 (54%), Gaps = 17/316 (5%)
Query: 289 ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR 348
+ A + G ER + R R K ++ ++ +R+R + K R R +R R RQ+DR
Sbjct: 42 LGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDR 101
Query: 349 RRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT-------REKIKEKERVKEKDREKERER 401
+ + R + R+R K R+R R++ + R+ ++ER +++D EKERER
Sbjct: 102 EKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER 161
Query: 402 EKEREKEKERGKNKDRDKEREKDREKDKEKDRERERE-----KEHEKDRDKEKEKEQDKE 456
+ +RE++++ +N+ +++EREK+R++ +E++R+RE+E + E+ R++E+E+E + E
Sbjct: 162 QTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETE 221
Query: 457 KEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIK 516
ER++ +E D +RK +++ AS R +ER R R R R R K +
Sbjct: 222 TERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRD-RRQKERE 280
Query: 517 RKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKE 576
R++ R R+ ++ +R++ER E RERER+ RK +R+ + + E+ + ++
Sbjct: 281 RQTDRKRQRRTERDRETERKRERQRERE-RERERN---RKRERERERERERERQRETERD 336
Query: 577 KEHNKEPDSSVSKEVD 592
+E +E E+D
Sbjct: 337 REKERERKRKRQTEMD 352
Score = 166 bits (419), Expect = 8e-41
Identities = 92/306 (30%), Positives = 173/306 (56%), Gaps = 11/306 (3%)
Query: 271 AAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ 330
A KE E R R+ Q+ + E E K+ + + R R R K + HS R R +
Sbjct: 155 AEKERERQTDRERQRQTERNRQKEREREKNRQER--RERERQREKENKTEDRHSERGRER 212
Query: 331 SKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERV 390
+ R R RQ DR R + +K + RE++ R R+ R+ +D +E+ +E++R
Sbjct: 213 ERERETETETERKRQTDRERDRQ--RKTEREREKQAERERASERETERD-KERERERDRD 269
Query: 391 KEKDR---EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDK 447
+++DR E+ER+ +++R++ ER + +R +ER+++RE+++E++R+RERE+E E++R++
Sbjct: 270 RDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERER 329
Query: 448 EKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSR 507
++E E+D+EKERE+ R ++ + R++++++ R R R R+R+ R R
Sbjct: 330 QRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERE 389
Query: 508 SPRTSKTIKRKSSRSPSPR-SRNKKDKKREKERDHISER-RERERSTSMRKSSNDRDGKE 565
R K + ++ R + + +K+RE+E+D SER RER R +K +RD +
Sbjct: 390 RDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQK-GRERDRER 448
Query: 566 KLEKNS 571
+ ++ +
Sbjct: 449 QTDRQA 454
Score = 144 bits (363), Expect = 2e-34
Identities = 89/303 (29%), Positives = 159/303 (52%), Gaps = 32/303 (10%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332
++ + +R RE Q+ A E E+ + ER+ R R R + + + + RKR +
Sbjct: 232 RDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRT 291
Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHS--RDKRKDTREKIK----- 385
R R R R RQ++R R + ++KR + RER + R R RD+ K+ K K
Sbjct: 292 ERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEM 351
Query: 386 EKERVKEKDREKEREREKEREKEKERGKN-----KDRDKEREKDREKDKEK--------- 431
++ER ++ RE R+ E+ERE+E+ER + ++R+++R++DR+K++E+
Sbjct: 352 DRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQ 411
Query: 432 ---DREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT-----PPRS 483
+++REREK+ E +R +E+ +E++K+K RE+DR ++ D + + +K T PPR+
Sbjct: 412 RETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRT 471
Query: 484 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHIS 543
+ +R R R +SS P+ + T R P+ SR + +R E +
Sbjct: 472 ARSGVVQSDPNRPTRGIRWKSSPEDPKAAST--RFPWGRPAKASRGRVAGRRRWE-PRLG 528
Query: 544 ERR 546
E+R
Sbjct: 529 EKR 531
Score = 71.6 bits (174), Expect = 2e-12
Identities = 57/219 (26%), Positives = 106/219 (48%), Gaps = 34/219 (15%)
Query: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE---------REKDRSKE 466
D + R +E + + + + DR++ ++KE+++ +E R+++R +E
Sbjct: 25 DFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE 84
Query: 467 IDEKRKKDK-KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP 525
D RK+D+ + R R R R + RER R+R + +R + +R+ R
Sbjct: 85 KDRHRKRDRHRERQRDRE---KERERQTDRERDRQREKERNRQKERERETEREGERG--- 138
Query: 526 RSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 585
R R + D +RE+ER +E +ERER T DR+ + + E+N +E+E N++
Sbjct: 139 RDR-QTDGQRERERQRDAE-KERERQT-------DRERQRQTERNRQKEREREKNRQ--- 186
Query: 586 SVSKEVDDKDAPRTEENKIQ--HNGNCQLNEENLSTKTE 622
E +++ R +ENK + H+ + E T+TE
Sbjct: 187 ----ERRERERQREKENKTEDRHSERGRERERERETETE 221
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 164 bits (414), Expect = 3e-40
Identities = 139/574 (24%), Positives = 251/574 (43%), Gaps = 87/574 (15%)
Query: 128 PIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEI-----PQPPLMGNVDPSKIDEIRR 182
P P P + V +S + P L P ++ +G+ P L +
Sbjct: 30 PPPVPPGTPMIPVPMSIMAPAPTV-LVPTVSMVGKHLGARKDHPGLKAKENDENCGPTT- 87
Query: 183 TVYVGNLNSQTTTADQLL-EFFKQVGEV-KFVRMAGDETQPTRFAFVEFADQNSVPRALA 240
TV+VGN++ + + D L+ + + G V + R+ G + F F E+ + S RAL
Sbjct: 88 TVFVGNISEKAS--DMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALR 145
Query: 241 F-NGVMFGDRPLKIN----------------HSNNAIVKPPEMTPQAAAKELEEVMKRVR 283
+ + G++ L + ++N +P +T EE +R +
Sbjct: 146 LLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQ 205
Query: 284 EAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRR----------------- 326
+ I I S + N S SH R K + + RR
Sbjct: 206 MIKGAIEVLIREYSSELNA-PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDI 264
Query: 327 ---KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRE-----RRKSRSRSHSRDKRK 378
+ + K S S+ R ++ + KK + +E R + R R R++R+
Sbjct: 265 NAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRE 324
Query: 379 DTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD-------------- 424
RE+ +E+ER KEK+RE+ERER+++R++ KER +++DR+++R++D
Sbjct: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384
Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484
REK ++++RERERE+E E++R++E+E+E+++E+ERE++R +E D+KR +++
Sbjct: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR 444
Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKE------ 538
R+ R + R R + ++ ++++ R R K+ KR KE
Sbjct: 445 KLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYD 504
Query: 539 ---------RDHISERRERERSTSMRKSSNDRD-GKEKLEKNSTSLKEKEHNKEPDSSVS 588
R ++R R+R M DR KE+LE+ L + H PD
Sbjct: 505 DDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGH---PDPDAE 561
Query: 589 KEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTE 622
+ +++A R + +I+ + EE K E
Sbjct: 562 LQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEE 595
Score = 152 bits (383), Expect = 1e-36
Identities = 88/314 (28%), Positives = 166/314 (52%), Gaps = 10/314 (3%)
Query: 293 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 352
+E E GK E++ R + R + RR+R + + R R + + R+++R R +
Sbjct: 291 LEEEKGKK-EKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDR 349
Query: 353 SPHKKRSKSRERRKSRSRSHSRDK-RKDTREKIKEKERVKEKDREKEREREKEREKEKER 411
+ R+K R+R + R R RD+ R R K + + R K +DRE+ERERE+ERE+E+ER
Sbjct: 350 D--RDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERER 407
Query: 412 GKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE---REKDRSKEID 468
+ ++R++ERE++RE+++EKD++R+RE++ E ++ K + + +EKE +E+ ++ EI
Sbjct: 408 EREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIR 467
Query: 469 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528
E++K + + R RR + +R + R R S+ R R
Sbjct: 468 ERKKTREYEKEAER--EEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDR 525
Query: 529 NKKDKKREKERDHISERRERERSTSMRKSSNDRDGK-EKLEKNSTSLKEKEHNKEPDSSV 587
K+ + E++R E E R + + D D + +++E+ + ++ + +EP+S
Sbjct: 526 EKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585
Query: 588 SKEVDDKDAPRTEE 601
+E + + EE
Sbjct: 586 EEEEKQEKEEKREE 599
Score = 126 bits (317), Expect = 5e-29
Identities = 85/310 (27%), Positives = 144/310 (46%), Gaps = 39/310 (12%)
Query: 276 EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS 335
EE K+ +E Q E E + ER+ R R R + R K R+R + + R
Sbjct: 293 EEKGKKEKERQEIEKERRERERERERERER-REREREREREREREKE-KERERERERDRD 350
Query: 336 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 395
R + R R +DR R + ++RS R + +SRSR SRD+ ++ RE+ +E+ER +E++R
Sbjct: 351 RDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERE-RERERERERERERER 409
Query: 396 EKEREREKEREKEKERGKNKDRDKE----------------REKDR-------------- 425
E+ERERE+ERE+E+ER K+K RD+E REK+
Sbjct: 410 EREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER 469
Query: 426 ------EKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 479
EK+ E++ ER RE E R KE ++ D +++ K +KR +D++
Sbjct: 470 KKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEM 529
Query: 480 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKER 539
+ R R+R + + +++++ R P+ + + + + E+E
Sbjct: 530 EADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEE 589
Query: 540 DHISERRERE 549
E + E
Sbjct: 590 KQEKEEKREE 599
Score = 108 bits (270), Expect = 1e-23
Identities = 79/309 (25%), Positives = 140/309 (45%), Gaps = 45/309 (14%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRK-RSQS 331
+E E +R RE + E + + ++ R R R + R +S R K RS+S
Sbjct: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384
Query: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTRE--------- 382
+ +SR R R R+++R R + ++R + RER + R R +DK++D E
Sbjct: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR 444
Query: 383 ----KIKEKE----------RVKEKDREKEREREKEREKEKER--GKNKDRDKEREKDRE 426
K++EKE ++E+ + +E E+E ERE+E+ R K R KE +D +
Sbjct: 445 KLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYD 504
Query: 427 KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNA 486
D++ + ++ RD+EKE E D E++R++++ +E++E R++ P
Sbjct: 505 DDRDDPKYYRGSALQKRLRDREKEMEAD-ERDRKREK-EELEEIRQRLLAEGHPDPDAEL 562
Query: 487 SRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR 546
R +E RRR + P S +K +K EK + + E
Sbjct: 563 QR----MEQEAERRRQPQIKQEPE-------------SEEEEEEKQEKEEKREEPMEEEE 605
Query: 547 ERERSTSMR 555
E E+ ++
Sbjct: 606 EPEQKPCLK 614
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 162 bits (409), Expect = 1e-39
Identities = 99/297 (33%), Positives = 163/297 (54%), Gaps = 37/297 (12%)
Query: 299 KSNERKGGRSRSHTRSKSRSSSKSHSR---------RKRSQSKHRSRSHNRSRSRQKDRR 349
+ R RS S RS RS S+SH R R+ + K R R ++ R+K+RR
Sbjct: 257 RRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERR 316
Query: 350 RSKSPHK--KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 407
RS+S + +R +SR R + RSRS SRD++ D R++ +E+E+ E ER R ++R+
Sbjct: 317 RSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREK------ENERGRRRDRDY 370
Query: 408 EKERGKNKDRDKEREKDREKDKE-KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKE 466
+KERG +R+KERE+ RE+ KE + R EK+H++D+D + ++ ++ ++EK S+
Sbjct: 371 DKERGN--EREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSR- 427
Query: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRER-------------RRRRSRSSSRSPRTSK 513
R +++K R+ RS NA +RSRS S+E+ +R RS S R+ K
Sbjct: 428 ---SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEK 484
Query: 514 TIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKN 570
+ KR+ S S + + K+R +RDH + + ++ R S +++ +EK KN
Sbjct: 485 SKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKN 541
Score = 148 bits (373), Expect = 2e-35
Identities = 99/291 (34%), Positives = 162/291 (55%), Gaps = 32/291 (10%)
Query: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT---REKIKEKERVK----EKDRE 396
R +RRRS+SP + S R R+SRSRSH R+ + RE +EKER + K+RE
Sbjct: 253 RHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE 312
Query: 397 KER----------EREKEREKEKERGKNKDRDKE---REKDREKDKEKDREREREKEHEK 443
KER ER + R +E+ R +++ RD++ R++DRE++KE +R R R+++++K
Sbjct: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372
Query: 444 DRDKEKEKEQDKEKEREKDRSK--EIDEKR----KKDKKSRTPPR-SYNASRRSRSSSRE 496
+R E+EKE+++ +ER K++ E++EK+ K D++ R R S + SRS SRE
Sbjct: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE 432
Query: 497 RRRR-RSRSSSRSPRTSKTIKRKSS--RSPSPRSRNKKDKKREKER-DHISERRERERST 552
R+ R RSRS + R+ K KSS ++ S NK+ + + R D + + ++RE S
Sbjct: 433 RKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSP 492
Query: 553 SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603
S KS KE+ K S K+ + + D S+ ++ + + +NK
Sbjct: 493 SKEKSRKRSRSKERSHKRDHS-DSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
Score = 110 bits (276), Expect = 3e-24
Identities = 74/275 (26%), Positives = 131/275 (47%), Gaps = 27/275 (9%)
Query: 272 AKELEEVMKRVREAQSFISAAIEPESGKSN--------ERKGGRSRSHTRSKSRSSSKSH 323
+ + ++R +E Q A E E + ER+ RSR RS+SRS +
Sbjct: 288 SSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG 347
Query: 324 SRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK 383
RR R + + + R R R D+ R K+R +SRE R K + +R +
Sbjct: 348 DRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRE----------RSKEQRSRGE 397
Query: 384 IKEKERVKEKDREKEREREKEREKEKERGKNKDRD-KEREKDREKDKEKDREREREKEHE 442
++EK+ ++KD + R+ +++ +KEK+ +++ R+ K R + R ++ K R R R KE
Sbjct: 398 VEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGK-RSRSRSKEKS 456
Query: 443 KDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRS 502
K K + ++K +R + S+ + +K KK P + +RSRS R +R S
Sbjct: 457 ---SKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHS 513
Query: 503 RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREK 537
S +S + R+ S+S S+ K+ K +++
Sbjct: 514 DSKDQSDKHD----RRRSQSIEQESQEKQHKNKDE 544
Score = 101 bits (252), Expect = 2e-21
Identities = 63/256 (24%), Positives = 116/256 (45%), Gaps = 21/256 (8%)
Query: 366 KSRSRSHSRDKRKDTREKIKEKERVKEKD--------REKEREREKEREKEKERGKNKDR 417
K+R R +D ++ E + ER + + R R R + +E + DR
Sbjct: 234 KTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDR 293
Query: 418 DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID--------- 468
+ EREK+R++ + + +ERE+E+ + D+ E+ + + +ER + RS+ D
Sbjct: 294 ELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRD 353
Query: 469 -EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRS 527
E+ K++++ R R Y+ + R + RE+ R RSR S+ R+ ++ K +
Sbjct: 354 REREKENERGRRRDRDYD---KERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDR 410
Query: 528 RNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV 587
R++ DK+ K+ S R RER R S + + + S K K +KE +
Sbjct: 411 RHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKR 470
Query: 588 SKEVDDKDAPRTEENK 603
S+ E++K
Sbjct: 471 SRSGSQGRTDSVEKSK 486
Score = 94.0 bits (232), Expect = 4e-19
Identities = 62/238 (26%), Positives = 113/238 (47%), Gaps = 14/238 (5%)
Query: 375 DKRKDTR-EKIKE--KERVKEKDR--EKEREREKEREKEKERGKNKDRDKEREKDREKDK 429
D++ TR KIK+ KE +E DR E+ R R R R + R + ++
Sbjct: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
Query: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
DRE EREKE ++ + KE+E+++ + R DR E ++ +SR RS + SR
Sbjct: 290 SFDRELEREKERQRLEREAKEREKERRRSRSIDRGLE-----RRRSRSRERHRSRSRSRD 344
Query: 490 SRSSSRERRRRRSRSSSRSPRTSKTI-KRKSSRSPSPRSRNKKDKKREKERDHISERRER 548
+ R+R R R + + R R + K + + R R+++ K ++ R + E++ +
Sbjct: 345 RKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHK 404
Query: 549 ERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQH 606
E R + RD K++ + + + +E++H S S+ + R++E +H
Sbjct: 405 EDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSR---SRSRNAGKRSRSRSKEKSSKH 459
Score = 51.6 bits (122), Expect = 2e-06
Identities = 45/177 (25%), Positives = 77/177 (43%), Gaps = 17/177 (9%)
Query: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501
+K+ D++ + K K+ K+ ++EID ++ ++SR+P RRS S R RR R
Sbjct: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVER-RRSRSP-------RRSLSPRRSPRRSR 277
Query: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDR 561
SRS R S + R+ R + ++ K+REKER RS S+ + R
Sbjct: 278 SRSHHREGHGSSSFDRELEREKERQRLEREAKEREKER---------RRSRSIDRGLERR 328
Query: 562 DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLS 618
+ + S S D +E +++ R + + + GN + E S
Sbjct: 329 RSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS 385
Score = 44.3 bits (103), Expect = 3e-04
Identities = 27/108 (25%), Positives = 52/108 (48%), Gaps = 1/108 (0%)
Query: 254 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 313
+ S NA + + + ++K E ++ + S KS +R+ S+ +R
Sbjct: 439 SRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSR 498
Query: 314 SKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKS 361
+SRS +SH +R S SK +S H+R RS+ ++ + HK + ++
Sbjct: 499 KRSRSKERSH-KRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDET 545
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 158 bits (399), Expect = 2e-38
Identities = 104/354 (29%), Positives = 180/354 (50%), Gaps = 42/354 (11%)
Query: 293 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 352
I+ S SN +RS + R + + + R S R R ++ +R
Sbjct: 583 IDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPS 642
Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK----- 407
SP + + ++ E + R R R D R + +ER +E++R++ERERE+ERE+
Sbjct: 643 SPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRERE 702
Query: 408 -----EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKE-QDKEKEREK 461
E+ER + ++R++E+E+DRE+D+++D +RERE+E E+DR+KE+E+E +++E+ERE+
Sbjct: 703 KERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERER 762
Query: 462 DRSKEIDEKRKKDK-----KSRTPPRSYNASRRSRSSSRERR--------------RRRS 502
+R +E + +R++++ K R R + + R RE+R R+S
Sbjct: 763 ERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKS 822
Query: 503 RSSSR---SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE--RRERERSTSMRKS 557
+ R SP ++ KR+ SP + N D K EK R +S+ R + RS S
Sbjct: 823 KKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHR-LLSQVVRPQESRSLSPSHL 881
Query: 558 SNDRDGKEKLE------KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQ 605
+ DR G+ K E K S+ E++ KE SSV K+ + + + + Q
Sbjct: 882 TEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQ 935
Score = 151 bits (381), Expect = 2e-36
Identities = 97/350 (27%), Positives = 176/350 (50%), Gaps = 23/350 (6%)
Query: 295 PESGKSNER------KGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR 348
PE G R S H ++RSS R ++ ++R + R +
Sbjct: 571 PEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERD 630
Query: 349 RRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKE 408
RR +R S R + R+ RD+R++ R + +R E+ RE++RERE++RE+E
Sbjct: 631 RRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERE 690
Query: 409 KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID 468
+ER + +DR++E+E++ E+++ ++REREREKE +++RD++++ ++++E+ERE+DR KE +
Sbjct: 691 RERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERE 750
Query: 469 EKRKKDKKSRTPPRSYNASR-----RSRSSSRERRRRR---SRSSSRSPRTSKTIKRKSS 520
+R++ ++ R R R R+R +ER R+R + R R K + +
Sbjct: 751 REREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIRED 810
Query: 521 RSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRD----GKEKLEKNSTSLKE 576
R+P +K KKR + S R+ +R R+ S D D G +K EK+ +
Sbjct: 811 RNPRDGHDERKSKKRYRNEGSPSPRQSPKR---RREHSPDSDAYNSGDDKNEKHRLLSQV 867
Query: 577 KEHNKEPDSSVSKEVDDKDAPRTEENK--IQHNGNCQLNEENLSTKTEAV 624
+ S S +D+ EE++ + + + E+ L K +V
Sbjct: 868 VRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSV 917
Score = 130 bits (326), Expect = 5e-30
Identities = 91/331 (27%), Positives = 165/331 (49%), Gaps = 26/331 (7%)
Query: 301 NERKGGRSRSHTRSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRS 359
++R+ R+R R + R + R R+R + + + R R R+R+++R R K ++R
Sbjct: 669 DDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERD 728
Query: 360 KSRE--RRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDR 417
+ R+ R + R R R+K ++ + +E+ER +E++RE+ERERE+ER +E +D+
Sbjct: 729 RDRDHDRERERERERDREKEREREREERERERERERERERERERERERARE------RDK 782
Query: 418 DKEREKD-REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK 476
++ER++D +KDK +D RE+ +E +DR+ ++ K K+R ++ + K ++
Sbjct: 783 ERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRR 842
Query: 477 SRTPPR-SYNA----SRRSRSSSRERRRRRSRSSSRSPRTS------KTIKRKSSRSPSP 525
+P +YN+ + + R S+ R + SRS S S T K RK R S
Sbjct: 843 EHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESS 902
Query: 526 RSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 585
R R ++ + +EK +R + E S R + D G + E TS + + NK+
Sbjct: 903 R-RYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAK 961
Query: 586 SVSKEVDDKDAPRTEENKIQHNGNCQLNEEN 616
K + K E++ GN + E+
Sbjct: 962 IQKKPIKKK----KEDDVGIERGNIETTSED 988
Score = 123 bits (309), Expect = 4e-28
Identities = 92/360 (25%), Positives = 175/360 (48%), Gaps = 37/360 (10%)
Query: 272 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGG---RSRSHTRSKSRSSSKSHSRRKR 328
++E+ + + +E++ + ++ +R+G R +SRS ++H R +
Sbjct: 479 SREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES 538
Query: 329 SQSKHRSRSHNRSRSRQKD----RRRSKSPHKKRSKSRERRKSRSRSHSRDKRK----DT 380
S+++ R+ S N SRS ++ R R + P SR R S+ SHS + +T
Sbjct: 539 SRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWET 598
Query: 381 REKIKEKERVKEKD-REKEREREKEREK-EKERGKNKDRDK-------------EREKD- 424
R E++R E+D R++ R+ ER E++R N++RD+ E E+D
Sbjct: 599 RSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDE 658
Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484
R +++ DR +R E ++RD+E+E+++++E+ERE++R +E +++R+ +++
Sbjct: 659 RREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERA------ 712
Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE 544
R R R+R R R R R + R+ R R R +++++RE+ER+ E
Sbjct: 713 REREREREKERDRERDRDRDHDRERERERERDREKERE---REREERERERERERERERE 769
Query: 545 R-RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603
R RERER+ K + E +K +EK D + D++ + + N+
Sbjct: 770 RERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNE 829
Score = 100 bits (250), Expect = 3e-21
Identities = 77/253 (30%), Positives = 128/253 (50%), Gaps = 35/253 (13%)
Query: 308 SRSHTRSKSRSSSKSHSRRKRSQSKHRSRS-HNRSRSRQKDR-------RRSKSPHKKR- 358
+RSHT + RS S + R R R H+ SR R+K + R+S+ KR
Sbjct: 1198 NRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRG 1257
Query: 359 ----SKSRERRKSRSRS------------HSRDKRKDTREKIKEKERVKEKDREKERERE 402
S S +R+ SRS S HSR D+R++++E++R E DRE+ERER
Sbjct: 1258 EPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRY-EHDRERERERR 1316
Query: 403 KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462
R++E +R + D+D R +DR++ +E++RERER+K + DR++E+ E++R++D
Sbjct: 1317 DTRQREWDR--DADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRD 1374
Query: 463 RSKEIDE------KRKKDKKSRTPPRSY-NASRRSRSSSRERRRRRSRSSSRSPRTSKTI 515
R + + KR + K R + SR S + +ER + S T+K+
Sbjct: 1375 RDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSE 1434
Query: 516 KRKSSRSPSPRSR 528
+ +S + S+
Sbjct: 1435 RTESLEAGDDESK 1447
Score = 98.2 bits (243), Expect = 2e-20
Identities = 76/318 (23%), Positives = 135/318 (42%), Gaps = 27/318 (8%)
Query: 269 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR--- 325
+A ++ E R RE + E E + ER+ R R R K R + R
Sbjct: 675 RARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHD 734
Query: 326 RKRSQSKHRSRSHNRSRSRQ-KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKI 384
R+R + + R R R R R+ ++R R + ++R + RER ++R R R++++D
Sbjct: 735 RERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDW---- 790
Query: 385 KEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE---REKEH 441
++KD+ ++ REK E ++R D+ + K R +++ R+ R +EH
Sbjct: 791 ------EDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREH 844
Query: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501
D D + EK R + E R P R+ R +R+ R
Sbjct: 845 SPDSDAYNSGDDKNEKHRLLSQVVRPQESRS------LSPSHLTEDRQGRWKEEDRKPER 898
Query: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNK-KDKKREKERDHISERRERERSTSMRKSSND 560
SS R + +K K S R + + + R + +D I + +R TS R + ++
Sbjct: 899 KESSRR--YEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDR-AHDE 955
Query: 561 RDGKEKLEKNSTSLKEKE 578
K K++K K+++
Sbjct: 956 NKKKAKIQKKPIKKKKED 973
Score = 94.4 bits (233), Expect = 3e-19
Identities = 81/321 (25%), Positives = 132/321 (41%), Gaps = 39/321 (12%)
Query: 263 PPEMTPQAAA-----KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317
PP P+ A KE +V R+ E + GK R R R R K R
Sbjct: 266 PPPPIPEDIALGKKYKEKYKVKDRIEE---------KTRDGKDRGRDFERQREK-RDKPR 315
Query: 318 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377
S+S + S+H S S S+S +R S SP +KR+ S +++ + R
Sbjct: 316 STSPAGQHHSPISSRHHSSS---SQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSAS 372
Query: 378 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKER------EKDREKDKEK 431
+ +R + R + REK R + ++ DR ER ++DREKD +
Sbjct: 373 PYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSRE 432
Query: 432 DREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSR 491
E+E+E+D+ ++ D+E +DR D + +D++ R SR R
Sbjct: 433 ------EREYEQDQSSSRDHRDDREPRDGRDRR---DARDTRDRRELRDSRDMRDSREMR 483
Query: 492 SSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER------ 545
SR+ + R SRS R + + + R + ++ R R+H+ E
Sbjct: 484 DYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEI 543
Query: 546 RERERSTSMRKSSNDRDGKEK 566
R R+ S + NDR G+ +
Sbjct: 544 RNESRNESRSEIRNDRMGRSR 564
Score = 90.5 bits (223), Expect = 4e-18
Identities = 80/347 (23%), Positives = 155/347 (44%), Gaps = 47/347 (13%)
Query: 300 SNERKGGRSRSHTRS--KSRSSSKSHSRR-----KRSQSKHRSRSHNRSRSRQKDRRRSK 352
S+ + G + H+ S + R+ S S+ R +RS S + S S + S R++ R +
Sbjct: 334 SSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLS-SPQRKQSPPRHR 392
Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERG 412
SP +++ + R S+S ++R+DTR K +++E+ ++RE E+++ R+ +R
Sbjct: 393 SPMREKGRHDHERTSQSHDRRHERREDTRGK-RDREKDSREEREYEQDQSSSRDHRDDRE 451
Query: 413 KNKDRDKEREKD-REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKR 471
RD+ +D R++ + +D R+ +D ++ ++ +D R + + ++
Sbjct: 452 PRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDRE 511
Query: 472 KKD--KKSRTPP---RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 526
+D +K T P RSY + SSR R SR+ SRS + + R R P
Sbjct: 512 GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELP 571
Query: 527 SRNKKDKKREK---------------------ERDHISER--RERERSTSMRKSSNDRDG 563
+ + + + ERD ER R++ R +S + +RD
Sbjct: 572 EKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDR 631
Query: 564 KEKLEKN---STSLKEKEHNKEPDSSVSKE------VDDKDAPRTEE 601
++ E++ S+ ++ + N E + +E VDD+ R E
Sbjct: 632 RDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARE 678
Score = 87.8 bits (216), Expect = 3e-17
Identities = 87/399 (21%), Positives = 155/399 (38%), Gaps = 94/399 (23%)
Query: 297 SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQ----------- 345
+ +S++R+ R R TR K S R+ Q + SR H R +
Sbjct: 406 TSQSHDRRHER-REDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDT 464
Query: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR-------------KDTREKIKEKERVKE 392
+DRR + R R SR SRD R ++ R+ ++++ E
Sbjct: 465 RDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPE 524
Query: 393 KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER----------------- 435
+ R R +E E + +N+ R++ R + R + R R
Sbjct: 525 ESRSYGRNHLRE-ESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQI 583
Query: 436 --------------------EREKEHEKD-RDKEKEK-------EQDKEKEREKDR---- 463
ER++ E+D RD+ ++ E+D+ RE+D+
Sbjct: 584 DSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSS 643
Query: 464 ---------SKEIDEKRKKDKKSRTPPRSYNASR---RSRSSSRERRRRRSRSSSRSPRT 511
E DE+R++ + R R +R R R RER R R R R
Sbjct: 644 PIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREK 703
Query: 512 SKTIKRKSSRSPSPRSRNKKDKKREKERDHISER-----RERERSTSMRKSSNDRDGKEK 566
+ ++R+ +R ++D++R+++RDH ER R+RE+ + +R+ + +
Sbjct: 704 ERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERE 763
Query: 567 LEKNSTSLKEKEHNKEPDSSVSKEVD--DKDAPRTEENK 603
E+ +E+E +E D ++ D DKD R + +
Sbjct: 764 RERERERERERERARERDKERERQRDWEDKDKGRDDRRE 802
Score = 77.0 bits (188), Expect = 5e-14
Identities = 87/339 (25%), Positives = 139/339 (41%), Gaps = 41/339 (12%)
Query: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRS--KSP---HKKRSKSRERRKSRSRSHSR 374
S S S RK S+S R S S + +KDR+ S SP ++ SK+ + +K R+ S
Sbjct: 207 SPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSP 266
Query: 375 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE-REKDREKDKEKDR 433
E I ++ KEK + K+R EK R+ K+RG++ +R +E R+K R
Sbjct: 267 PP--PIPEDIALGKKYKEKYKVKDRIEEKTRD-GKDRGRDFERQREKRDKPRSTSPAGQH 323
Query: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK-----KDKKSRTPPRSYNASR 488
H + Q + R+ +R + S P S ++ +
Sbjct: 324 HSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQ 383
Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR--NKKDKKREKE-------- 538
R +S R R R + RTS++ R+ R R + +KD + E+E
Sbjct: 384 RKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSS 443
Query: 539 RDHISERRERE-------RSTSMRKSSND-RDGKEKLEKNSTSLKEKEHNKEPDSSVSKE 590
RDH +R R+ R T R+ D RD ++ E S KE DS +++
Sbjct: 444 RDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRD 503
Query: 591 VDD------KDAPRTEENKIQHN---GNCQLNEENLSTK 620
D +D R E+ + + G L EE+ T+
Sbjct: 504 AHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTE 542
Score = 72.8 bits (177), Expect = 9e-13
Identities = 54/200 (27%), Positives = 93/200 (46%), Gaps = 20/200 (10%)
Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSR----------RKRSQSKH-RSRSHNRSR 342
EP S++R+ RS S RS S + HSR ++R + +H R R R
Sbjct: 1258 EPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRD 1317
Query: 343 SRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE 402
+RQ++ R R++ R+R + R R RDKR+D +E+ER+ E++R+R+
Sbjct: 1318 TRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLD---RERERLISDSVERDRDRD 1374
Query: 403 KEREKEKERGKNKDR-----DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEK 457
++R E + ++ R + E E+D E ++E+ +KD + E+ +
Sbjct: 1375 RDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKER-MDKDLGSVQGFEETNKS 1433
Query: 458 EREKDRSKEIDEKRKKDKKS 477
ER + DE + D S
Sbjct: 1434 ERTESLEAGDDESKLDDAHS 1453
Score = 63.5 bits (153), Expect = 5e-10
Identities = 76/289 (26%), Positives = 126/289 (43%), Gaps = 24/289 (8%)
Query: 330 QSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT-REKIKEKE 388
+ K S ++ RS R R + +K++ E +K + S RK++ R + +EKE
Sbjct: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE 125
Query: 389 RVKEKDREKEREREKER-EKEKERGKNKDRDKEREKDREKDKEKDR---EREREKEHEKD 444
+K +E+ E E+E E E R + + D + E E R +RE K +++
Sbjct: 126 DIKIT-KERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQEN 184
Query: 445 RDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRS 504
+K +E KE E RSK + K S++P R +S +S S+S++ R+ + S
Sbjct: 185 MEKREEIIIKKEVSPEVVRSK-LSPSPSLRKSSKSPKR--KSSPKSSSASKKDRKTSAVS 241
Query: 505 SS--RSPRTSKT--IKRKSSRSPSPR-------SRNKKDKKREKERDHISER----RERE 549
S R SKT K+K R+PSP + KK K++ K +D I E+ ++R
Sbjct: 242 SPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRG 301
Query: 550 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPR 598
R ++ D+ S H+ S S +PR
Sbjct: 302 RDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPR 350
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/397 (21%), Positives = 144/397 (36%), Gaps = 108/397 (27%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332
+ELE R RE + E + + ++R+ R R R K R + R+R + +
Sbjct: 705 RELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERER 764
Query: 333 HRSRSHNRSRSRQKDRRRSKSPHK-----------KRSKSRERRKSRSRSHSRDKRK--- 378
R R R R R ++R + + + +R K E R+ R+ D+RK
Sbjct: 765 ERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKK 824
Query: 379 -------------------------------DTREK-------IKEKE------------ 388
D EK ++ +E
Sbjct: 825 RYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTED 884
Query: 389 ---RVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKD-----------------REK 427
R KE+DR+ ER+ R +E+E + K DK+RE+ + +
Sbjct: 885 RQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSE 944
Query: 428 DKE-KDREREREKEHEKDRDK--EKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484
D+E DR + K+ K + K +K+KE D ER + D + KK +
Sbjct: 945 DRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQ------ 998
Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE--KERDHI 542
+ S E++R++S+ S + K R P K++ E ++ I
Sbjct: 999 ------KKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGI 1052
Query: 543 SERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579
E +++ T+ S D D ++ T + E EH
Sbjct: 1053 LEDSQKKEDTAFSDWS-DEDVPDR-----TEVTEAEH 1083
Score = 42.0 bits (97), Expect = 0.002
Identities = 46/242 (19%), Positives = 87/242 (35%), Gaps = 39/242 (16%)
Query: 401 REKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE 460
R K R + RE+ + K ++ D E ++ E KE + + +E+E
Sbjct: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE 125
Query: 461 -----KDRSKEIDEKRKKDKKSRTPP-----------------RSYNASRRSRSSSRERR 498
K+R+ E +E+ + + +R + R +E
Sbjct: 126 DIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENM 185
Query: 499 RRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERST------ 552
+R + + + ++ K S SPS R +K K++ + + +++R+ S
Sbjct: 186 EKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLL 245
Query: 553 SMRKSSNDRDGKEK-----------LEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 601
+++S K+K E + K KE K D K D KD R E
Sbjct: 246 DQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFE 305
Query: 602 NK 603
+
Sbjct: 306 RQ 307
Score = 40.0 bits (92), Expect = 0.006
Identities = 73/380 (19%), Positives = 127/380 (33%), Gaps = 51/380 (13%)
Query: 261 VKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSS 320
+ P +T + EE K R+ S E + K + R T S
Sbjct: 876 LSPSHLTEDRQGRWKEEDRKPERKESS---RRYEEQELKEKVSSVDKQREQTEILESSRM 932
Query: 321 KSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSR---ERRKSRSRSHSRD-- 375
++ QS+ R S +K + K P KK+ + ER + S
Sbjct: 933 RAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVF 992
Query: 376 -KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDR- 433
+K ++K EK+R K K + E ++ +K+RG +E+ E K+
Sbjct: 993 SPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGI 1052
Query: 434 -EREREKEHEKDRDKEKEKEQDKEK--EREKDRSKEIDEKRKKDKKSRTPP--------- 481
E ++KE D E D+ + E E + S PP
Sbjct: 1053 LEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATA 1112
Query: 482 ---------------RSYNASRRSRSSS-------------RERRRRRSRSSSRSPRTSK 513
S++ S + S+S + R+ R+ T
Sbjct: 1113 TTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPH 1172
Query: 514 -TIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNST 572
TI+ R P + R+ R H S R + S +S +D+ G++++ + +
Sbjct: 1173 VTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGS 1232
Query: 573 SLKEKEHNKEPDSSVSKEVD 592
+EK + E +D
Sbjct: 1233 RDREKTKSLEITGERKSRID 1252
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 151 bits (381), Expect = 2e-36
Identities = 111/364 (30%), Positives = 176/364 (48%), Gaps = 44/364 (12%)
Query: 299 KSNERKG--------GRSRSHTRSKSRSSSKSHSRRK-----RSQSKHRSRSHNRSRSRQ 345
+S RKG +SRSH++ KS++ S++ R + R+ SK RS SH+RS S++
Sbjct: 315 RSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKE 374
Query: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKD-TREKIKEKERVKEKDREKEREREKE 404
+D R S SP K+ +S+ ++ R HSR + + R++ + + K +DR + R K
Sbjct: 375 RDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKA 434
Query: 405 REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKE------KE 458
R+ + R K RD+ R + K ++ R R K ++ R + KE+D KE
Sbjct: 435 RDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKE 494
Query: 459 REKDRSKEIDEKRK-KDKKSRTPPRSYNASRRSRSSSRERRRR--------RSRSSSRSP 509
R+ RS+ ++R+ + +S + R + RRSRS S+ER+RR R RS SRSP
Sbjct: 495 RDHRRSRSPSKERQCRQSRSSSKERDH---RRSRSPSKERQRRQSRSPNKERDRSQSRSP 551
Query: 510 RTSKTIKRKSSRSPSPRSRNKKDKKREKERDH-----ISERRERERSTSMRKSSN----D 560
S+ + + SRSPS ++ + KER+ SE R+ RS S K S
Sbjct: 552 --SEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPR 609
Query: 561 RDGKEKLEKNS-TSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLST 619
KEK S T KE H++ SS + PR+ + K L++ +
Sbjct: 610 ASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPS 669
Query: 620 KTEA 623
KT +
Sbjct: 670 KTSS 673
Score = 135 bits (341), Expect = 9e-32
Identities = 101/337 (29%), Positives = 172/337 (51%), Gaps = 40/337 (11%)
Query: 290 SAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRR 349
S++ ESG+S + R H+RS+S + ++ SR RS K R RS +RS ++ +D
Sbjct: 380 SSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSR-SRSPYKARDRSRSRSPNKARDCS 438
Query: 350 RSKSPHKKRSKSRERRKSRSRSHSRDK-----RKDTREKIKEKER--------VKEKDRE 396
RS+SP+K R +SR R +++R HSR + R +R + KER KE+D
Sbjct: 439 RSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHR 498
Query: 397 KEREREKEREKEKERGKNKDRD----------KEREKDREKDKEKDRERER----EKEHE 442
+ R KER+ + R +K+RD ++R + R +KE+DR + R E+EH
Sbjct: 499 RSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHR 558
Query: 443 KDRDKEKEKEQDK----EKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERR 498
+ R KE+++ + KERE+ +S+ E+R +SR+P + S R R+SS+E+
Sbjct: 559 QSRSPSKERDRRRWRSPSKERERRQSRSSSEER-DHSRSRSPNKQSGYS-RPRASSKEKA 616
Query: 499 RRRSRSSSR--SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556
RSR+ S+ + S+T ++S S S R+ K+ +S+ R +++S
Sbjct: 617 HSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSP 676
Query: 557 SSNDRDG----KEKLEKNSTSLKEKEHNKEPDSSVSK 589
S+ G ++ + ++T+ K + SS SK
Sbjct: 677 STFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713
Score = 134 bits (338), Expect = 2e-31
Identities = 107/357 (29%), Positives = 164/357 (45%), Gaps = 25/357 (7%)
Query: 254 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 313
N S N + ++++KE + +S S + P + + R +++ R
Sbjct: 354 NWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDR 413
Query: 314 SKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR--SKSRERRKSRSR 370
S+SRS K+ R R RS +K R S +RS + +DR RS+SP+K R S+SR K+R R
Sbjct: 414 SRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDR 473
Query: 371 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKE 430
S SR K+ R+ + KE+D + R KER+ + R +K+RD R R KE
Sbjct: 474 SRSRSPSKE-RDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRR--SRSPSKE 530
Query: 431 KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRS 490
+ R + R E+DR + + +++E + + SKE D +R + P R+S
Sbjct: 531 RQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRS------PSKERERRQS 584
Query: 491 RSSSRERRRRRSRSSSRS-----PRTSKTIKRKS-SRSPSPRSRNKKDKKREKERDHISE 544
RSSS ER RSRS ++ PR S K S SR+PS + + + KE D
Sbjct: 585 RSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESD--PS 642
Query: 545 RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE--PDSSVSKEVDDKDAPRT 599
+ RS ++S L +N T K H+ P + DD A T
Sbjct: 643 QSTVPRSPDWKRSPT---RTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADAT 696
Score = 129 bits (325), Expect = 6e-30
Identities = 94/307 (30%), Positives = 153/307 (49%), Gaps = 30/307 (9%)
Query: 303 RKGGRSRSHTRSKSRSSSKSHSR-----RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKK 357
R G + R+H+R +S S ++HSR RK S+ S +RS S+ K + +S++P +
Sbjct: 291 RSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRG 350
Query: 358 RSK--SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 415
RS SR K RS SHSR K+ + R KE R + K+R+ + R NK
Sbjct: 351 RSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPR-KESGRSQSGSPNKQRDHSRSRSPNK 409
Query: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK 475
RD+ R + K +++ R R K + R + K +D+ + R +++++ R +K
Sbjct: 410 ARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNK 469
Query: 476 -----KSRTPPRSYNASRRSRSSSRERRRRRSRSSSR------SPRTSKTIKRKSSRSPS 524
+SR+P + + S+ S S+ER RRSRS S+ S +SK + SRSPS
Sbjct: 470 ARDRSRSRSPSKERDHSQLG-SPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPS 528
Query: 525 PRSRNKKDKKREKERDHI-----SERRERERSTSMRKSSNDR----DGKEKLEKNS-TSL 574
+ ++ + KERD SE RE +S S K + R KE+ + S +S
Sbjct: 529 KERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSS 588
Query: 575 KEKEHNK 581
+E++H++
Sbjct: 589 EERDHSR 595
Score = 112 bits (281), Expect = 8e-25
Identities = 90/329 (27%), Positives = 152/329 (46%), Gaps = 34/329 (10%)
Query: 296 ESGKSNERKGGRSRSHTRSKSRSSSKSHS-----RRKRSQSKHRSRSHNRSRSRQKDRRR 350
E S R +S+ ++ +RS +SHS RR RS S+ R+ S RS S +++ R
Sbjct: 254 EKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSR 313
Query: 351 SKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKE 410
++S +K S+ R S+SRSHS+ K ++ + + + R R KE
Sbjct: 314 ARSRTRKGILSQMGRHSQSRSHSKGKSQN-----------QSRTPRRGRSHNWSRNPSKE 362
Query: 411 RGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK 470
R + R +E+D +E R + ++ ++ + + K R++ RS+ K
Sbjct: 363 RSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRS-PYK 421
Query: 471 RKKDKKSRTPPRSYNASR-----RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP 525
+ +SR+P ++ + SR ++R SR R ++R SRS +K R SRSPS
Sbjct: 422 ARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSK 481
Query: 526 RSRNKKDKKREKERDHISER---RERERSTSMRKSSNDRD-------GKEKLEKNSTS-L 574
+ + KERDH R +ER+ S R SS +RD KE+ + S S
Sbjct: 482 ERDHSQLGSPSKERDHRRSRSPSKERQCRQS-RSSSKERDHRRSRSPSKERQRRQSRSPN 540
Query: 575 KEKEHNKEPDSSVSKEVDDKDAPRTEENK 603
KE++ ++ S +E +P E ++
Sbjct: 541 KERDRSQSRSPSEEREHRQSRSPSKERDR 569
Score = 72.0 bits (175), Expect = 2e-12
Identities = 86/354 (24%), Positives = 139/354 (39%), Gaps = 20/354 (5%)
Query: 266 MTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR 325
+ P A VM + ++ S + + R R RS R+ SR S+ + +
Sbjct: 44 LVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRS--RVRSKARTPSRVSTDTRTS 101
Query: 326 R--KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK 383
+ K S + R SR R RR S+S KRS SR R R+H +R +
Sbjct: 102 KASKASDVRCHQRRGTHSRGRTPGRRGSRS--SKRSPSRASTPGRIRTHGARPGMASRVR 159
Query: 384 IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREK-----DREKDKEKDRERERE 438
++ + + R R RE+ + +N + R R + +
Sbjct: 160 TPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKC 219
Query: 439 KEHEKDRDKEKEKEQDKEKERE-KDRSKEIDEKRKKD---KKSRTPPRSYN-ASRRSR-- 491
+ KEK R+ K + I R+K + + +SYN AS RSR
Sbjct: 220 QTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQ 279
Query: 492 SSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERS 551
S S+ R RRSRS S+ RT ++ S + R+R++ K + S+ R +
Sbjct: 280 SHSQSRSPRRSRSGSQK-RTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKG 338
Query: 552 TSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQ 605
S +S R G+ + S KE+ H+ SS ++ +PR E + Q
Sbjct: 339 KSQNQSRTPRRGRSHNWSRNPS-KERSHSHSRSSSKERDHRGSSSPRKESGRSQ 391
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 149 bits (376), Expect = 8e-36
Identities = 81/259 (31%), Positives = 143/259 (55%), Gaps = 20/259 (7%)
Query: 331 SKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER-RKSRSRSHSRDKRKDTREKIKEKER 389
S+ R S RS + + R + R+R R+ + RD+++D + KEKE
Sbjct: 50 SRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKET 109
Query: 390 VKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEK 449
+ +DREK+ E E++RE+EK++G+ ++RD+ RE++R++D+EK+RER+ EK+ + R+ E
Sbjct: 110 NRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETET 169
Query: 450 EKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP 509
E+E+D+E+E++K+R E D R++D + R R + RER R+R + R
Sbjct: 170 ERERDREREKQKERETERDRDRQRDTEKE----------RERQTDRERDRQRKTQTERQR 219
Query: 510 RTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEK 569
T + +R++ R R ++D+ R KERD RER+R +K KE+ EK
Sbjct: 220 ETDREGERETDR----RRERQRDRDRGKERD-----RERDRKEERKKERKKERKKERKEK 270
Query: 570 NSTSLKEKEHNKEPDSSVS 588
+ ++ ++ +S
Sbjct: 271 KKEEKRREDKKRKWGEGIS 289
Score = 149 bits (376), Expect = 8e-36
Identities = 84/264 (31%), Positives = 147/264 (55%), Gaps = 30/264 (11%)
Query: 314 SKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHS 373
S+ R S+ R H+ + R R++DR R K+ K R+R + R R
Sbjct: 50 SRGRLGSQESPRSWGLGQAHKDADGD-DRQRERDRVREKT-----EKERDRDRKRDRERR 103
Query: 374 RDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDR 433
R +++ R + +EK+ E+DRE RE++K RE+E++RG+ ++RD++REK+RE+ EKDR
Sbjct: 104 RKEKETNRNRDREKQTEIERDRE--REKQKGRERERDRGRERERDRDREKERERQTEKDR 161
Query: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSS 493
+ +RE E E++RD+E+EK++++E ER++DR ++ +++R+ R +
Sbjct: 162 DGQRETETERERDREREKQKERETERDRDRQRDTEKERE------------------RQT 203
Query: 494 SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS 553
RER R+R + R T + +R++ R R ++D+ R KERD +R+E +
Sbjct: 204 DRERDRQRKTQTERQRETDREGERETDR----RRERQRDRDRGKERDRERDRKEERKKER 259
Query: 554 MRKSSNDRDGKEKLEKNSTSLKEK 577
++ +R K+K EK K K
Sbjct: 260 KKERKKERKEKKKEEKRREDKKRK 283
Score = 140 bits (353), Expect = 3e-33
Identities = 64/214 (29%), Positives = 125/214 (58%), Gaps = 2/214 (0%)
Query: 289 ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR 348
+ A + G +R+ R R T K R + R +R + K +R+ +R + + +R
Sbjct: 65 LGQAHKDADGDDRQRERDRVREKTE-KERDRDRKRDRERRRKEKETNRNRDREKQTEIER 123
Query: 349 RRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR-EKIKEKERVKEKDREKEREREKEREK 407
R + K R + R+R + R R R+K ++ + EK ++ +R E +RE++REREK++E+
Sbjct: 124 DREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKER 183
Query: 408 EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEI 467
E ER +++ RD E+E++R+ D+E+DR+R+ + E +++ D+E E+E D+ +ER++DR +
Sbjct: 184 ETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGK 243
Query: 468 DEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501
+ R++D+K ++ R ++ +RR
Sbjct: 244 ERDRERDRKEERKKERKKERKKERKEKKKEEKRR 277
Score = 140 bits (352), Expect = 5e-33
Identities = 79/247 (31%), Positives = 130/247 (52%), Gaps = 36/247 (14%)
Query: 298 GKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSH---NRSRSRQKDRRRSKSP 354
G++++ G R R + R ++ R R + + R R NR+R R+K +
Sbjct: 66 GQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDR 125
Query: 355 HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 414
+++ K RER + R R RD R++ KE+ER EKDR+ +RE E ERE+++ER K
Sbjct: 126 EREKQKGRERERDRGRERERD-----RDREKERERQTEKDRDGQRETETERERDREREKQ 180
Query: 415 KDRDKEREKDREKDKEKDREREREKEHEKDR--DKEKEKEQDKEKEREKDRSKEIDEKRK 472
K+R+ ER++DR++D EK+RER+ ++E ++ R E+++E D+E ERE DR +E
Sbjct: 181 KERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRE------ 234
Query: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD 532
+R R +ER R R R R +RK R + + K++
Sbjct: 235 --------------RQRDRDRGKERDRERDRKEERKK------ERKKERKKERKEKKKEE 274
Query: 533 KKREKER 539
K+RE ++
Sbjct: 275 KRREDKK 281
Score = 133 bits (335), Expect = 4e-31
Identities = 72/242 (29%), Positives = 129/242 (53%), Gaps = 20/242 (8%)
Query: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358
+ + R G ++H + + R + K R R R R R R K R
Sbjct: 57 QESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRER-----RRKEKETNR 111
Query: 359 SKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 418
++ RE++ R R+K+K RE+ +++ R +E+DR++E+ER ER+ EK+R ++ +
Sbjct: 112 NRDREKQTEIERDREREKQKG-RERERDRGRERERDRDREKER--ERQTEKDRDGQRETE 168
Query: 419 KEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSR 478
ERE+DRE++K+K+RE ER+++ ++D +KE+E++ D+E++R+ R + + +R+ D++
Sbjct: 169 TERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQ--RKTQTERQRETDRE-- 224
Query: 479 TPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKE 538
R RER+R R R R + +RK R + K+ KK EK
Sbjct: 225 --------GERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKR 276
Query: 539 RD 540
R+
Sbjct: 277 RE 278
Score = 132 bits (332), Expect = 1e-30
Identities = 65/199 (32%), Positives = 125/199 (62%), Gaps = 13/199 (6%)
Query: 296 ESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ-SKHRSRSHNRSRSRQKDRRRSKSP 354
E + +RK R R R K + ++++ R K+++ + R R + R R++DR R +
Sbjct: 89 EKERDRDRKRDRER---RRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERER 145
Query: 355 HKKRSKSRERRKSRSRSHSRD---KRKDTREKIKEKERVKEKDR------EKEREREKER 405
+ R K RER+ + R R+ +R+ RE+ K+KER E+DR EKERER+ +R
Sbjct: 146 DRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDR 205
Query: 406 EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 465
E++++R +R +E +++ E++ ++ RER+R+++ K+RD+E++++++++KER+K+R K
Sbjct: 206 ERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKK 265
Query: 466 EIDEKRKKDKKSRTPPRSY 484
E EK+K++K+ R +
Sbjct: 266 ERKEKKKEEKRREDKKRKW 284
Score = 121 bits (304), Expect = 2e-27
Identities = 68/222 (30%), Positives = 123/222 (55%), Gaps = 14/222 (6%)
Query: 376 KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER 435
K D ++ +E++RV+EK EKER+R+++R++E+ R KE+E +R +D+EK E
Sbjct: 70 KDADGDDRQRERDRVREKT-EKERDRDRKRDRERRR-------KEKETNRNRDREKQTEI 121
Query: 436 EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495
ER++E EK + +E+E+++ +E+ER++DR KE + + +KD+ + + R R +
Sbjct: 122 ERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQK 181
Query: 496 ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD---HISERRERERST 552
ER R R R T K +R++ R + + + +++RE +R+ RRER+R
Sbjct: 182 ERETERDRDRQRD--TEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDR 239
Query: 553 SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 594
R DR+ K E+ KE++ ++ K +DK
Sbjct: 240 D-RGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDK 280
Score = 115 bits (287), Expect = 2e-25
Identities = 62/193 (32%), Positives = 111/193 (57%), Gaps = 18/193 (9%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332
KE E R RE Q+ E E + E++ GR R R + R R R + K
Sbjct: 105 KEKETNRNRDREKQT------EIERDREREKQKGRERERDRGRERE-------RDRDREK 151
Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392
R R + R Q++ + ++R K +ER R R RD K+ RE+ ++ER ++
Sbjct: 152 ERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKE-RERQTDRERDRQ 210
Query: 393 K----DREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKE 448
+ +R++E +RE ERE ++ R + +DRD+ +E+DRE+D++++R++ER+KE +K+R ++
Sbjct: 211 RKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEK 270
Query: 449 KEKEQDKEKEREK 461
K++E+ +E ++ K
Sbjct: 271 KKEEKRREDKKRK 283
Score = 94.7 bits (234), Expect = 2e-19
Identities = 58/193 (30%), Positives = 106/193 (54%), Gaps = 10/193 (5%)
Query: 418 DKEREKDREKDK-EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK- 475
D++RE+DR ++K EK+R+R+R+++ E+ R KEKE ++ ++REK E D +R+K K
Sbjct: 76 DRQRERDRVREKTEKERDRDRKRDRERRR---KEKETNRNRDREKQTEIERDREREKQKG 132
Query: 476 KSRTPPRSYNASR-RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK 534
+ R R R R R RER+ + R R T + R+ + + +D++
Sbjct: 133 RERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQ 192
Query: 535 R--EKERDHISER-RERERST-SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKE 590
R EKER+ ++R R+R+R T + R+ DR+G+ + ++ ++++ KE D ++
Sbjct: 193 RDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRK 252
Query: 591 VDDKDAPRTEENK 603
+ K + E K
Sbjct: 253 EERKKERKKERKK 265
Score = 67.4 bits (163), Expect = 4e-11
Identities = 48/206 (23%), Positives = 94/206 (45%), Gaps = 25/206 (12%)
Query: 423 KDREKDKEKDREREREKEHEKDRDKEKEKEQDK-----EKEREKDRSKEIDEKRKKDKKS 477
+ R +E R + H+ ++++E+D+ EKER++DR ++ + +RK+ + +
Sbjct: 51 RGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETN 110
Query: 478 RTPPRSYNAS-----RRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD 532
R R R + RER R R R R K +R++ + + + +
Sbjct: 111 RNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETE 170
Query: 533 KKREKERDHISER-----RERERSTSM---RKSSNDRDGKEKLEKNSTSLKEKEHNKEPD 584
++R++ER+ ER R+R+R T R++ +RD + K + ++E +E D
Sbjct: 171 RERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETD 230
Query: 585 SSVSKEVD-------DKDAPRTEENK 603
++ D D++ R EE K
Sbjct: 231 RRRERQRDRDRGKERDRERDRKEERK 256
Score = 67.4 bits (163), Expect = 4e-11
Identities = 39/141 (27%), Positives = 73/141 (51%), Gaps = 5/141 (3%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332
KE E ++ R+ Q E E + E++ R R + R + K R+ + +
Sbjct: 151 KERERQTEKDRDGQR--ETETERERDREREKQKERETERDRDRQRDTEKERERQT-DRER 207
Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392
R R R R+ DR + ++R + R+R + + R RD RK+ R+K ++KER KE
Sbjct: 208 DRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERD-RKEERKKERKKERKKE 266
Query: 393 KDREKEREREKEREKEKERGK 413
+ +EK++E ++ +K+++ G+
Sbjct: 267 R-KEKKKEEKRREDKKRKWGE 286
Score = 53.1 bits (126), Expect = 7e-07
Identities = 41/153 (26%), Positives = 70/153 (45%), Gaps = 9/153 (5%)
Query: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNK-K 531
KD R + R R+R R+R R R + + + + ++ R R + K
Sbjct: 70 KDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREK 129
Query: 532 DKKREKERDHISER-RERERSTSM-RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK 589
K RE+ERD ER R+R+R R++ DRDG+ + E +E+E KE ++
Sbjct: 130 QKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETE--- 186
Query: 590 EVDDKDAPRTEENKIQHNGNCQLNEENLSTKTE 622
D+D R E + + + + + + T+TE
Sbjct: 187 --RDRDRQRDTEKERERQTDRERDRQR-KTQTE 216
Score = 35.0 bits (79), Expect = 0.21
Identities = 29/121 (23%), Positives = 52/121 (42%), Gaps = 11/121 (9%)
Query: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKR---------EKERDHISER-RERERSTSMR 555
SR S+ R + + + D++R EKERD +R RER R
Sbjct: 50 SRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKET 109
Query: 556 KSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVD-DKDAPRTEENKIQHNGNCQLNE 614
+ DR+ + ++E++ K+K +E D +E D D++ R + + +G +
Sbjct: 110 NRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETET 169
Query: 615 E 615
E
Sbjct: 170 E 170
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 145 bits (367), Expect = 8e-35
Identities = 100/317 (31%), Positives = 160/317 (50%), Gaps = 24/317 (7%)
Query: 293 IEPESGKSNERKGGRSRSHTRSKSRS--SSKSHSRR---KRSQSKHRSRSHNRSRSRQKD 347
+E + G R RSRSH+RS+SRS S KS SR K S SK RSRS + SRSR K
Sbjct: 173 VEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKS 232
Query: 348 RRRSKS---PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKD---REKERER 401
R RS+S K++S+S + KSRSRSHS K + ++ K + +E+++ D + K R
Sbjct: 233 RSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSR-SKSKDQAEEKIQNNDNVGKPKSRSP 291
Query: 402 EKEREKEKERGKNKDRDKEREK--------DREKDKEKDREREREKEHEKDRDKEKEKEQ 453
+ + K K R ++++R E EK +EK + R R R K + R + + K +
Sbjct: 292 SRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSK 351
Query: 454 DKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSK 513
DK K R++ R + R + K R+ R ++ SS ++++ RS SRSP S
Sbjct: 352 DKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSV 411
Query: 514 TIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNS-T 572
+ +R+ ++S S + + + + E R R RS S K + + + + + S T
Sbjct: 412 SKEREHAKSESSQREGRGESENAGTN---QETRSRSRSNSKSKPNLPSESRSRSKSASKT 468
Query: 573 SLKEKEHNKEPDSSVSK 589
+ K ++ S S+
Sbjct: 469 RSRSKSRSRSASRSPSR 485
Score = 125 bits (314), Expect = 1e-28
Identities = 112/403 (27%), Positives = 189/403 (46%), Gaps = 69/403 (17%)
Query: 182 RTVY---VGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRA 238
RT Y V NL+S+ + D L ++ +Q GEV + A +EF + + RA
Sbjct: 101 RTEYRLIVENLSSRCSWQD-LKDYMRQAGEVTY---ADAHKGRKNEGVIEFVSYSDMKRA 156
Query: 239 LA-FNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPES 297
L +G R +++ KP ++ ++ R R S S + S
Sbjct: 157 LEKLDGTEVNGRKIRLVED-----KPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSS 211
Query: 298 GKSNERKGGRSRSHTRSKSRSSSKSHSR--------RKRSQSKHRSRSHN--RSRSRQKD 347
S+ + RSRS +RS+S+S S+S SR R S+ K RSRSH+ +SRS+ KD
Sbjct: 212 KSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKD 271
Query: 348 RRRSKSPH-------KKRSKSRERRKSRSRSHSRDKRKDTREKI-----KEKERVKEKDR 395
+ K + K RS SR + KS+SRS S+++R + ++ + +E+ + R
Sbjct: 272 QAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSR 331
Query: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER---EREKEHEKDRDKE---- 448
+ R + R + + R K+KD+ K R++ RE+ + + R R ER ++ RD +
Sbjct: 332 SRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSS 391
Query: 449 -KEKEQDKEKEREKDRSKEIDEKRKKDK-------------------KSRTPPRSYNASR 488
K+K++D ++ + + S+ + ++R+ K ++R+ RS + S+
Sbjct: 392 KKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSK 451
Query: 489 -------RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS 524
RSRS S + R RS+S SRS S + R S S S
Sbjct: 452 PNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494
Score = 73.2 bits (178), Expect = 7e-13
Identities = 70/312 (22%), Positives = 109/312 (34%), Gaps = 79/312 (25%)
Query: 349 RRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKE 408
R+ + K R R SRSRSHSR + + R + R + +
Sbjct: 168 RKIRLVEDKPGSRRRRSYSRSRSHSRSR---------------SRSRHSRKSRSRSGSSK 212
Query: 409 KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID 468
K++ R + + R K + + + R R K+ EK R KEK + + K RSK D
Sbjct: 213 SSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKK-EKSRSPSKEKSRSRSHSAGKSRSKSKD 271
Query: 469 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS---- 524
+ +K + + + SRSP K+ + SRS
Sbjct: 272 QAEEKIQNNDNV---------------------GKPKSRSPSRHKSKSKSRSRSQERRVE 310
Query: 525 ---------------------------------PRSRNKKDKKREKERDHISERRERERS 551
RSR+K KR+ + E R R RS
Sbjct: 311 EEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRS 370
Query: 552 TSMRKSSNDRDGKEKLEKNSTSLKEKE-----HNKEPDSSVSKEVDDKDAPRTEENKIQH 606
S + S R K + S+ K+KE ++ P SVSKE + + ++
Sbjct: 371 RSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGE 430
Query: 607 NGNCQLNEENLS 618
+ N N+E S
Sbjct: 431 SENAGTNQETRS 442
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 140 bits (353), Expect = 3e-33
Identities = 71/206 (34%), Positives = 127/206 (61%), Gaps = 21/206 (10%)
Query: 340 RSRSRQKDRRRSKSPHKKRSKSRER-----RKSRSRSHSRDKRKDTR-EKIKEKERVKEK 393
R R R+++ R K ++R + RER R++R R R + +D + ++ KE+ER KE+
Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62
Query: 394 DREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQ 453
DR+++RERE ERE E++R + + R+++R+ DRE+DK++DRER+RE + ++R+++ +E+
Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRER 122
Query: 454 DKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSK 513
DK+ ERE+DR +E +R++++ +R R RE R R R + R R
Sbjct: 123 DKQTERERDRERERQRQRERER------------QRQRERKRETDRERQRWAEREERKK- 169
Query: 514 TIKRKSSRSPSPRSRNKKDKKREKER 539
+RK R + + K++K+RE ++
Sbjct: 170 --ERKKERKKERKEKKKEEKRREDKK 193
Score = 137 bits (344), Expect = 4e-32
Identities = 63/197 (31%), Positives = 121/197 (61%), Gaps = 8/197 (4%)
Query: 356 KKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 415
++R + RE + + RD++++ + + + R +++DR +ER+R+ +REKE+ER K +
Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62
Query: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK--RKK 473
DR ++RE++ E++ E+ RER+R++E ++ D+E++K++D+E++RE DR++E + K R++
Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRER 122
Query: 474 DKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDK 533
DK++ R R R+R R R R R T + +R + R + R K+ K
Sbjct: 123 DKQTE------RERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERK 176
Query: 534 KREKERDHISERRERER 550
K KE+ +RRE ++
Sbjct: 177 KERKEKKKEEKRREDKK 193
Score = 133 bits (335), Expect = 4e-31
Identities = 61/195 (31%), Positives = 123/195 (63%), Gaps = 12/195 (6%)
Query: 302 ERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKS 361
ER+ R R R K + R + +Q++ +R R R R++DR+ + ++R K
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 362 RERRKSRSRSHSRD-----KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD 416
R+R++ R R R+ +R+ RE+ ++ +R ++KDR++ER+RE +R +E+ R ++
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121
Query: 417 RDK----EREKDREKDKEKDREREREKEHEKDRDKEKEK---EQDKEKEREKDRSKEIDE 469
RDK ER+++RE+ ++++RER+R++E +++ D+E+++ ++++KER+K+R KE E
Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKE 181
Query: 470 KRKKDKKSRTPPRSY 484
K+K++K+ R +
Sbjct: 182 KKKEEKRREDKKRKW 196
Score = 133 bits (334), Expect = 6e-31
Identities = 64/212 (30%), Positives = 128/212 (60%), Gaps = 20/212 (9%)
Query: 325 RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKI 384
+R+R + R + R R RQ++R +++ + R + R+R + R R R+K ++ R+K
Sbjct: 4 QRERKRETDRGKETERERDRQRERE-NQTERENRHRQRDRHRERDRQTDREKERE-RQKE 61
Query: 385 KEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKD 444
++++R +E++ E+E ER++ER++++ER + DR++++++DRE+ +E DR RER ++ ++
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121
Query: 445 RDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRS 504
RDK+ E+E+D+E+ER++ R +E +R+ R R + RER+R R
Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRE----------------RKRETDRERQRWAERE 165
Query: 505 SSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536
+ R K ++K + + ++DKKR+
Sbjct: 166 ERKKER--KKERKKERKEKKKEEKRREDKKRK 195
Score = 128 bits (321), Expect = 2e-29
Identities = 68/206 (33%), Positives = 123/206 (59%), Gaps = 17/206 (8%)
Query: 279 MKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSH 338
M+R RE + E + GK ER+ R R R H +R R + + R
Sbjct: 1 MERQRERKR------ETDRGKETERE--RDRQRERENQTERENRHRQRDRHRERDRQTDR 52
Query: 339 NRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT-REKIKEKERVKEKDREK 397
+ R RQK+R R + ++ + ER++ R R R ++ D R+K +++ER +E DR +
Sbjct: 53 EKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNR 112
Query: 398 EREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR-----DKEKEKE 452
ER R+ RE++K+ + +DR++ER++ RE+++++ RER+RE + E+ R +++KE++
Sbjct: 113 ERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERK 172
Query: 453 QDKEKEREKDRSKEIDEKRKKDKKSR 478
++++KER K++ KE EKR++DKK +
Sbjct: 173 KERKKER-KEKKKE--EKRREDKKRK 195
Score = 122 bits (307), Expect = 8e-28
Identities = 65/203 (32%), Positives = 123/203 (60%), Gaps = 25/203 (12%)
Query: 385 KEKERVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKDREKDKEKDREREREKEHEK 443
+++ER +E DR KE ERE++R++E+E + + ++R ++R++ RE+D++ DRE+ERE++ E+
Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62
Query: 444 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 503
DR +++E+E ++E ER+++R ++ + KR+ D++ R + RER+R R
Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDRE------------RDKDRDRERKRETDR 110
Query: 504 SSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER---RERERSTSM-RKSSN 559
+ R+ RK R ++ ++D++RE++R ER RER+R T R+
Sbjct: 111 NRERN--------RKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWA 162
Query: 560 DRDGKEKLEKNSTSLKEKEHNKE 582
+R+ ++K K + KE KE
Sbjct: 163 EREERKKERKKERKKERKEKKKE 185
Score = 120 bits (302), Expect = 3e-27
Identities = 60/198 (30%), Positives = 118/198 (59%), Gaps = 8/198 (4%)
Query: 381 REKIKEKERVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKDREKDKEKDREREREK 439
RE+ +E +R KE +RE++R+RE+E + E+E R + +DR +ER++ +++KE++R++ER++
Sbjct: 5 RERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDR 64
Query: 440 EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 499
+ +++R+ E+E E+ +E++R+++R ++ D +R KD+ + R+R RER +
Sbjct: 65 QRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDK 124
Query: 500 RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 559
+ R R + +R+ R + K++ RE++R E R++ER +K
Sbjct: 125 QTERERDRERERQRQRERERQR----QRERKRETDRERQRWAEREERKKERKKERKK--- 177
Query: 560 DRDGKEKLEKNSTSLKEK 577
+R K+K EK K K
Sbjct: 178 ERKEKKKEEKRREDKKRK 195
Score = 115 bits (288), Expect = 1e-25
Identities = 51/191 (26%), Positives = 116/191 (60%), Gaps = 2/191 (1%)
Query: 376 KRKDTREKIKEKERVKEKDREKERERE-KEREKEKERGKNKDRDKEREKDREKDKEKDRE 434
KR+ R K E+ER ++++RE + ERE + R++++ R +++ D+E+E++R+K++++ R+
Sbjct: 8 KRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQ 67
Query: 435 REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS 494
RERE E E +R +E++++++++++ +++R K+ D +RK++ R + +
Sbjct: 68 RERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTE 127
Query: 495 RERRRRRSRSSSRSPRTSKTIKRK-SSRSPSPRSRNKKDKKREKERDHISERRERERSTS 553
RER R R R R + +RK + R ++++K+E++++ ER+E+++
Sbjct: 128 RERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKEKKKEEK 187
Query: 554 MRKSSNDRDGK 564
R+ + G+
Sbjct: 188 RREDKKRKWGE 198
Score = 100 bits (250), Expect = 3e-21
Identities = 58/193 (30%), Positives = 110/193 (56%), Gaps = 16/193 (8%)
Query: 415 KDRDKEREKDREKDKEKDREREREKEHEKDRD-KEKEKEQDKEKEREKDRSKEIDEKRKK 473
+ R+++RE DR K+ E++R+R+RE+E++ +R+ + +++++ +E++R+ DR KE + ++++
Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62
Query: 474 DKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK-- 531
D++ + + + R R R+R R+R R + KR++ R+ R RN+K
Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRN---RERNRKGG 119
Query: 532 ---DKKREKERDHISER---RERERSTSM-RKSSNDRDGK---EKLEKNSTSLKEKEHNK 581
DK+ E+ERD ER RERER RK DR+ + E+ E+ KE++ +
Sbjct: 120 RERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKER 179
Query: 582 EPDSSVSKEVDDK 594
+ K +DK
Sbjct: 180 KEKKKEEKRREDK 192
Score = 76.6 bits (187), Expect = 6e-14
Identities = 44/146 (30%), Positives = 76/146 (52%), Gaps = 4/146 (2%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQS 331
+E E ++ R+ Q E E+ + ER+ R R R R K R RKR
Sbjct: 52 REKERERQKERDRQRQRERETERETERQRERQ--RQRERKRQTDRERDKDRDRERKRETD 109
Query: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 391
++R R+ R R K R + ++R + RER + R R R+ ++ + + +ER K
Sbjct: 110 RNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKK 169
Query: 392 EKDREKEREREKEREKEKERGKNKDR 417
E+ +E+++ER KE++KE++R ++K R
Sbjct: 170 ERKKERKKER-KEKKKEEKRREDKKR 194
Score = 75.9 bits (185), Expect = 1e-13
Identities = 50/189 (26%), Positives = 93/189 (49%), Gaps = 20/189 (10%)
Query: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSS 493
ER+RE++ E DR KE E+E ++++RE++ E + + ++ + R R + R
Sbjct: 2 ERQRERKRETDRGKETERE--RDRQRERENQTERENRHRQRDRHRERDR-----QTDREK 54
Query: 494 SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS 553
RER++ R R R T + +R+ R + + D++R+K+RD RER+R T
Sbjct: 55 ERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRD-----RERKRETD 109
Query: 554 MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLN 613
+ N + G+E+ ++ E+E ++E + +E ++ R E K + + Q
Sbjct: 110 RNRERNRKGGRERDKQT-----ERERDRERERQRQRE---RERQRQRERKRETDRERQRW 161
Query: 614 EENLSTKTE 622
E K E
Sbjct: 162 AEREERKKE 170
Score = 74.7 bits (182), Expect = 2e-13
Identities = 46/150 (30%), Positives = 82/150 (54%), Gaps = 10/150 (6%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQS 331
KE E +R R+ Q E E+ + ER+ R R R + + R R+R +
Sbjct: 54 KERERQKERDRQRQR------ERETERETERQRERQRQRERKRQTDRERDKDRDRERKRE 107
Query: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 391
R+R NR R++D++ + ++R + R+R + R R R KR+ RE+ + ER +
Sbjct: 108 TDRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRER-KRETDRERQRWAER-E 165
Query: 392 EKDREKEREREKER-EKEKERGKNKDRDKE 420
E+ +E+++ER+KER EK+KE + +D+ ++
Sbjct: 166 ERKKERKKERKKERKEKKKEEKRREDKKRK 195
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 139 bits (349), Expect = 1e-32
Identities = 73/221 (33%), Positives = 131/221 (59%), Gaps = 12/221 (5%)
Query: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKD 379
SK+ R ++++ R R R R+ DR R ++ K SK+ +R R R R++
Sbjct: 3 SKTEGRHTHTETETMDRQ--RERRRETDRERDRA---KESKTEDRHSERDRQRDRERN-- 55
Query: 380 TREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREK 439
RE+ +++ER K+ DRE ER+RE+ER+++++R ++RDKERE DR + +++R++++E+
Sbjct: 56 -RERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKER 114
Query: 440 EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 499
E E+ RD+E+EK+++ +ER+ DR + + +R+ +++ T R R R RER+R
Sbjct: 115 EMERVRDREREKQKEMGRERQTDRETDRERERQAERERET-GRERKTEDRHRERERERKR 173
Query: 500 RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD 540
R R R T + + + R K+D++RE ER+
Sbjct: 174 ERERKRETKERERHTDMERERQRETDR---KRDRQRESERE 211
Score = 130 bits (328), Expect = 3e-30
Identities = 74/223 (33%), Positives = 125/223 (56%), Gaps = 28/223 (12%)
Query: 362 RERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKER 421
R+R + R RD+ K+++ + + ER +++DRE+ RER+++RE+EK+ + +R +ER
Sbjct: 19 RQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRER 78
Query: 422 EKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP 481
E+DR D++++ ERER+KE E DR E ++E+ K+KERE +R + D +R+K K+
Sbjct: 79 ERDR--DRQRETERERDKERETDRHTETDRERQKQKEREMERVR--DREREKQKE----- 129
Query: 482 RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDH 541
R R + RE R R R + R T R R +D+ RE+ER+
Sbjct: 130 -----MGRERQTDRETDRERERQAERERETG-------------RERKTEDRHRERERER 171
Query: 542 ISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPD 584
E RER+R T R+ D + + + E + +++E +E D
Sbjct: 172 KRE-RERKRETKERERHTDMERERQRETDRKRDRQRESERERD 213
Score = 128 bits (322), Expect = 1e-29
Identities = 62/199 (31%), Positives = 119/199 (59%), Gaps = 13/199 (6%)
Query: 313 RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSH 372
R + R + + R K S+++ R +R R R+++R R + +++ RE + R R
Sbjct: 21 RERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERER 80
Query: 373 SRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREK----DREKD 428
RD++++T +E+++ +E DR E +RE++++KE+E + +DR++E++K +R+ D
Sbjct: 81 DRDRQRETE---RERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTD 137
Query: 429 KEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASR 488
+E DRERER+ E E++ +E+ K +D+ +ERE++R +E + KR+ ++ R +
Sbjct: 138 RETDRERERQAERERETGRER-KTEDRHRERERERKRERERKRETKERER-----HTDME 191
Query: 489 RSRSSSRERRRRRSRSSSR 507
R R +R+R R R S R
Sbjct: 192 RERQRETDRKRDRQRESER 210
Score = 125 bits (315), Expect = 9e-29
Identities = 67/192 (34%), Positives = 113/192 (58%), Gaps = 15/192 (7%)
Query: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358
+ ER+ R R+K + HS R R + + R+R +R R R+K R ++R
Sbjct: 19 RQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRER 78
Query: 359 SKSRERRKSRSRSHSRDKRKDT-REKIKEKERVKEKDREKEREREKEREKEKERGKNKDR 417
+ R+R++ R RDK ++T R ++ER K+K+RE ER R++EREK+KE G+ +
Sbjct: 79 ERDRDRQRETERE--RDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQT 136
Query: 418 DKEREKDREKDKEKDREREREK-------EHEKDRDKEKE-KEQDKEKER----EKDRSK 465
D+E +++RE+ E++RE RE+ E E++R +E+E K + KE+ER E++R +
Sbjct: 137 DRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDMERERQR 196
Query: 466 EIDEKRKKDKKS 477
E D KR + ++S
Sbjct: 197 ETDRKRDRQRES 208
Score = 117 bits (294), Expect = 2e-26
Identities = 62/202 (30%), Positives = 112/202 (55%), Gaps = 13/202 (6%)
Query: 277 EVMKRVREAQSFISAAIE-PESGKSNERKGGRSRSHTRSKSRSSSKSHSRRK-------R 328
E M R RE + + + K+ +R R R R ++R + R K R
Sbjct: 15 ETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGER 74
Query: 329 SQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKE 388
+ + R R R R++D+ R H + + R+++K R RD+ REK KE
Sbjct: 75 QRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRE---REKQKEMG 131
Query: 389 RVKEKDREKEREREKEREKEKERGK-NKDRDKEREKDREKDKEKDRERE-REKEHEKDRD 446
R ++ DRE +RERE++ E+E+E G+ K D+ RE++RE+ +E++R+RE +E+E D +
Sbjct: 132 RERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDME 191
Query: 447 KEKEKEQDKEKEREKDRSKEID 468
+E+++E D++++R+++ +E D
Sbjct: 192 RERQRETDRKRDRQRESERERD 213
Score = 72.0 bits (175), Expect = 2e-12
Identities = 38/147 (25%), Positives = 72/147 (48%), Gaps = 8/147 (5%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQS 331
K+ + +R RE + E E + ER+ R R + + + R R R +
Sbjct: 66 KQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRERE 125
Query: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR-------KSRSRSHSRDKRKDTREKI 384
K + R R+ DR R + ++R RER+ + R R R+++++T+E+
Sbjct: 126 KQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERE 185
Query: 385 KEKERVKEKDREKEREREKEREKEKER 411
+ + +E+ RE +R+R+++RE E+ER
Sbjct: 186 RHTDMERERQRETDRKRDRQRESERER 212
Score = 57.0 bits (136), Expect = 5e-08
Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 32/142 (22%)
Query: 267 TPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRR 326
T + K+ E M+RVR+ + E + ER+ R R + + R
Sbjct: 104 TDRERQKQKEREMERVRDRER------EKQKEMGRERQTDRETDRERERQAERERETGRE 157
Query: 327 KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKE 386
++++ +HR R R R R++ K+ +K RER E
Sbjct: 158 RKTEDRHRERERERKRERER---------KRETKERERHTD-----------------ME 191
Query: 387 KERVKEKDREKEREREKEREKE 408
+ER +E DR+++R+RE ERE++
Sbjct: 192 RERQRETDRKRDRQRESERERD 213
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 138 bits (348), Expect = 1e-32
Identities = 109/373 (29%), Positives = 178/373 (47%), Gaps = 54/373 (14%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332
KE + RV+E + + + NE++ + SK R ++ + + ++K
Sbjct: 392 KENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNK 451
Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392
+ R+ ++SRS+ K++ +SK K +++ E+R RSRS RD E +KEKE+ +
Sbjct: 452 VKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRM-RSRSKGRD-----HENVKEKEKQSD 505
Query: 393 -KDREKEREREKEREKEKERGKNK-DRDKEREKDRE-----------KDKEKDREREREK 439
K +++ER R KE+ K+ E N+ D K +EKDR K K R RE+
Sbjct: 506 SKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRER 565
Query: 440 EHEKDRD---KEKEKEQDKEKEREKDRSKEIDEKRK---KDKKSRTPPRSYNASRRSRSS 493
+DR + + ++D+ + +E R +E + +R+ + ++ RTPP RSRS
Sbjct: 566 SRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPP------GRSRSK 619
Query: 494 SRERRRRRSRSSSR--SPRTSKTIKRKSSRSPSPRSRNKKDKKR--EKERDHISERRERE 549
R RRRR SRSS R S +K R S R N + +KR K RDH S RE
Sbjct: 620 DRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSRE 679
Query: 550 RS--------TSMRKSSNDRDGKEKLEKNSTSLK-----EKEHNKEPDS------SVSKE 590
+ + +++SS D + K + KN K EKE+ K +K+
Sbjct: 680 KKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKK 739
Query: 591 VDDKDAPRTEENK 603
D + +P T+E+K
Sbjct: 740 FDHESSPGTDEDK 752
Score = 137 bits (344), Expect = 4e-32
Identities = 105/383 (27%), Positives = 196/383 (51%), Gaps = 36/383 (9%)
Query: 267 TPQAAAKELEEVMK-RVREAQSFISA-AIEPESGKSNERKGGRSRSHTRSKSRSSSKSHS 324
TP +E++ + RV + +I E K N+R R + + R+ S+S +
Sbjct: 358 TPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPN 417
Query: 325 RRKRSQSKHRSRSHNRSRSRQKD-RRRSKSPHKKRSKSRERRKSRSRSHSRDKRK----D 379
R+ + K + ++S S+++D RR S+ K ++K ++R KS+SRS S++K K D
Sbjct: 418 RKNEKEKKVKD---HKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERD 474
Query: 380 TREKIKEKERVKEKDREKEREREKEREKEKE-RGKNKDRDKEREK-----------DREK 427
++ E++R++ + + ++ E KE+EK+ + +GK+++R + +EK D K
Sbjct: 475 SKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSK 534
Query: 428 DKEKDRE-REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP----R 482
KEKDR + R +E + + K + +E+ R +DRS+ + + +SR+ R
Sbjct: 535 SKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYR 594
Query: 483 SYNASRRSRSSSRERR----RRRSRSSSRSPRTSKTIKRKSSRSPS-PRSRNKKDKKREK 537
RR RS SRERR R RS+ R R S++ +R+ S+S + + RN++ K +
Sbjct: 595 EQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHR 654
Query: 538 ERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTS-LKEKEHNKEPDSSVSKEVDD--- 593
+ + SE+R +S S+N R+ K +++ S +K+ + E SS+ K +D
Sbjct: 655 KENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKI 714
Query: 594 KDAPRTEENKIQHNGNCQLNEEN 616
+ + E K + N ++E+N
Sbjct: 715 RSSVEKENQKSKGQENDHVHEKN 737
Score = 126 bits (317), Expect = 5e-29
Identities = 99/356 (27%), Positives = 168/356 (47%), Gaps = 59/356 (16%)
Query: 298 GKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSR-------------------SH 338
G+ R SRS +R + R S R+ Q R R +
Sbjct: 335 GRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKEN 394
Query: 339 NRSRSRQKDRRR------SKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392
RS R K+R+ S+SP++K K ++ + +S S RD R+++ + K K +VK+
Sbjct: 395 QRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKK 454
Query: 393 KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKE-- 450
R + K R K KE+ K+K+RD + ++ EK + R R + ++HE ++KEK+
Sbjct: 455 ------RAKSKSRSKSKEKSKSKERDSKHNRNEEK---RMRSRSKGRDHENVKEKEKQSD 505
Query: 451 -KEQDKEKEREKDRSKEIDEK---------RKKDKKSRTPPR---------SYNASRRSR 491
K +D+E+ R K++SK+++ K ++KD+++++ R SYN+ R R
Sbjct: 506 SKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRER 565
Query: 492 SSSRERRRR-RSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE---KERDHISERRE 547
S SR+R RR RSR+ R SK R + R R++ ++R + R RR
Sbjct: 566 SRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRR 625
Query: 548 RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603
R+ +S R+ S R+ + + S S KE+++ SK D + + E K
Sbjct: 626 RDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKK 681
Score = 97.4 bits (241), Expect = 3e-20
Identities = 97/413 (23%), Positives = 172/413 (41%), Gaps = 79/413 (19%)
Query: 265 EMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHS 324
E+ P++ K+ E+ + + S S+ + S + S S T KS+ K H
Sbjct: 176 ELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKH- 234
Query: 325 RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSR-------SHSRDKR 377
+ SR H + + ++K ++S S + + +S R +R
Sbjct: 235 -------RKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLM 287
Query: 378 KDTREKIKEKERVKEKDREKERERE------------------KEREKEKERGKNKDRDK 419
+ + K EKER K+RE+ERERE + K K RG + R
Sbjct: 288 RKSPPKADEKER---KNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTP 344
Query: 420 EREKDREKDKEKD------REREREK--------------EHEKDRDKEKEKEQDKEKER 459
R + R++ + + +E +R + + E + KE ++ + KER
Sbjct: 345 SRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKER 404
Query: 460 ---------EKDRSKEIDEKRKKDKKSRTPPRSY--NASRRSRSSSRERRRRRSRSSSRS 508
E K EK+ KD KS + R N+ + + ++ ++R +S+S S+S
Sbjct: 405 KITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKS 464
Query: 509 PRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLE 568
SK+ +R S + R+ K+ + R K RDH + + + ++S S K KEK +
Sbjct: 465 KEKSKSKERDSKHN---RNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSK 521
Query: 569 KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE---NKIQHNGNCQLNEENLS 618
+ + E +H+K SKE D + R+ E K +H+ N + E + S
Sbjct: 522 QLESKSNEHDHSK------SKEKDRRAQSRSRECDITKGKHSYNSRTRERSRS 568
Score = 95.5 bits (236), Expect = 1e-19
Identities = 75/307 (24%), Positives = 131/307 (42%), Gaps = 46/307 (14%)
Query: 266 MTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR 325
M ++ ++ E V ++ +++ S S + +++ +S H SKS+ +
Sbjct: 485 MRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQS 544
Query: 326 RKR----SQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR 381
R R ++ KH S R RSR +DR R+ RSR+H RD R
Sbjct: 545 RSRECDITKGKHSYNSRTRERSRSRDR---------------SRRVRSRTHDRD-----R 584
Query: 382 EKIKEKERVKEKD-REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE 440
+ KE R +E++ R + R R +ER R ++KDR + R R E+E
Sbjct: 585 SRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSS----------ERE 634
Query: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR- 499
+ R+K+K + Q+ + K+ S+ EKR K R +N+S SR +R +
Sbjct: 635 ESQSRNKDKYRNQESKSSHRKENSE--SEKRMYSKS-----RDHNSSNNSREKKADRDQS 687
Query: 500 ---RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556
+ +SS + S +K K + K + +E DH+ E+ ++ S
Sbjct: 688 PFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPG 747
Query: 557 SSNDRDG 563
+ D+ G
Sbjct: 748 TDEDKSG 754
Score = 87.4 bits (215), Expect = 4e-17
Identities = 91/376 (24%), Positives = 159/376 (42%), Gaps = 54/376 (14%)
Query: 270 AAAKELEEVMKRVREAQSFI-SAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 328
AA+K EV R+ I + ++ E K ++ S S + S S S S+S S
Sbjct: 161 AASKPFAEV--RILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSD 218
Query: 329 SQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKE 388
S+S +S R + +K+ R+ K KKR KS++ S S + + + + + + +E
Sbjct: 219 SESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIP 278
Query: 389 RVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKE 448
+ E + K EKE+ +++ERE++RE + + ++ R
Sbjct: 279 PIPENRFLMRKSPPKADEKER-------KNRERERERECNPPNSQPASYQRRLLVTRSGR 331
Query: 449 KEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP---RSYNASRRSRSSSRERRRRRSRS- 504
K K + + R RS+ D R+ S TPP + ++R R SS ER + +S
Sbjct: 332 KIKGRGPRRYRTPSRSRSRDRFRR----SETPPHWRQEMQRAQRMRVSSGERWIKGDKSE 387
Query: 505 ------SSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRER---------- 548
+ RSP K K R+ S S N+K++K +K +DH S +ER
Sbjct: 388 LNEIKENQRSPVRVKERKITDHRNVS-ESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDD 446
Query: 549 -------------------ERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK 589
E+S S + S +EK ++ + ++ E+ KE +
Sbjct: 447 KYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDS 506
Query: 590 EVDDKDAPRTEENKIQ 605
+ D++ R++E Q
Sbjct: 507 KGKDQERSRSKEKSKQ 522
Score = 87.4 bits (215), Expect = 4e-17
Identities = 74/253 (29%), Positives = 121/253 (47%), Gaps = 36/253 (14%)
Query: 254 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 313
+H N VK E + K+ E + + Q S + E + KS E K R++S +R
Sbjct: 493 DHEN---VKEKEKQSDSKGKDQERSRSKEKSKQ-LESKSNEHDHSKSKE-KDRRAQSRSR 547
Query: 314 SKSRSSSK-SHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSP-----------HKKRSKS 361
+ K S++ R R +S+ R RS R RSR DR RS+S + RS+S
Sbjct: 548 ECDITKGKHSYNSRTRERSRSRDRSR-RVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRS 606
Query: 362 RERRKSRSRSHSRD---KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 418
RERR RS S+D +R+D+R +E+ + + KD+ + +E + KE + +
Sbjct: 607 RERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYS 666
Query: 419 KERE-----KDREKDKEKDRE-----REREKEHEKDRDKEKEKEQDK-----EKEREKDR 463
K R+ REK ++D+ ++ +++E K KE +K EKE +K +
Sbjct: 667 KSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSK 726
Query: 464 SKEIDEKRKKDKK 476
+E D +K+KK
Sbjct: 727 GQENDHVHEKNKK 739
Score = 67.8 bits (164), Expect = 3e-11
Identities = 56/232 (24%), Positives = 99/232 (42%), Gaps = 33/232 (14%)
Query: 252 KINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSH 311
K N +++ K + Q+ ++E + + S+ S E + R+ RSR+H
Sbjct: 526 KSNEHDHSKSKEKDRRAQSRSRECDITKGK----HSYNSRTRERSRSRDRSRRV-RSRTH 580
Query: 312 TRSKSRSSS-------------KSHSR-------RKRSQSKHRSRSHNRSRSRQKDRRRS 351
R +SRS +S SR R RS+ + R R +RS R++ + R+
Sbjct: 581 DRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRN 640
Query: 352 KSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDRE-----KEREREKERE 406
K ++ + RK S S R K R K+ DR+ K ++ ++ E
Sbjct: 641 KDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNE 700
Query: 407 KEKERGKNKDRDKER---EKDREKDKEKDREREREKEHEKDRDKEKEKEQDK 455
+ KNK+ +K R EK+ +K K ++ + EK + D + ++DK
Sbjct: 701 LKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDK 752
>gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]
Length = 285
Score = 132 bits (331), Expect = 1e-30
Identities = 72/187 (38%), Positives = 116/187 (62%), Gaps = 6/187 (3%)
Query: 293 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 352
+ P + ER+ R R R+K R K K + + R R R R R +DR+R +
Sbjct: 52 VAPAIIRERERQRERERQRKRAKERHREKDREIEK-DRDRQRKRDRERQRWRDRDRKRER 110
Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEK-ER 411
+ R ER++ R R R + KD RE+ +++E +KDRE E E++++RE+E E
Sbjct: 111 WGDRDRETETERQEERERQRDRKREKD-RERQRQREIGIDKDREIETEKDRDREREMGET 169
Query: 412 GKNKDRDKEREKDREKDKEKDREREREKE-HEKDRDKEKEKEQDKEKERE--KDRSKEID 468
+ +DR++ER+K RE +++DRER+REKE E+DRD++KE+E+D+ +ERE +DR KE D
Sbjct: 170 ERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERD 229
Query: 469 EKRKKDK 475
+R+++K
Sbjct: 230 RERQREK 236
Score = 130 bits (327), Expect = 4e-30
Identities = 68/192 (35%), Positives = 123/192 (64%), Gaps = 21/192 (10%)
Query: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK 385
R+R + + R R + R R+KDR K ++R + RER++ R R R++ D R++
Sbjct: 60 RERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGD-RDRET 118
Query: 386 EKERVKEKDREKEREREKEREKEKER--GKNKDRDKEREKDREKDKE-------KDRERE 436
E ER +E++R+++R+REK+RE++++R G +KDR+ E EKDR++++E +DRERE
Sbjct: 119 ETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERE 178
Query: 437 REKEHEKDRDKEKEKEQDKE-KEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495
R+K+ E RD+++E++++KE +ER++DR KE ++ R ++++ + R R R
Sbjct: 179 RQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERE----------TGRDRDKER 228
Query: 496 ERRRRRSRSSSR 507
+R R+R + R
Sbjct: 229 DRERQREKDRDR 240
Score = 127 bits (319), Expect = 3e-29
Identities = 63/187 (33%), Positives = 117/187 (62%), Gaps = 12/187 (6%)
Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSK 352
E E + ER+ R++ R K R K R RKR + + R R +R R R DR R
Sbjct: 59 ERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRET 118
Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTR-EKIKEKERVKEKDREKE-------REREKE 404
++ + R+R + R + R ++++ +K +E E K++DRE+E R+RE+E
Sbjct: 119 ETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERE 178
Query: 405 REKEKERGKNKDRDKEREKD---REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK 461
R+K++E +++DR+++REK+ R++D++K+RE++R +E E RD++KE+++++++E+++
Sbjct: 179 RQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREKDR 238
Query: 462 DRSKEID 468
DR K ID
Sbjct: 239 DRQKAID 245
Score = 119 bits (299), Expect = 6e-27
Identities = 62/204 (30%), Positives = 116/204 (56%), Gaps = 9/204 (4%)
Query: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK 403
R+++R+R + +KR+K R R K R RD++ R++ +E++R +++DR++ER ++
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQ---RKRDRERQRWRDRDRKRERWGDR 114
Query: 404 EREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR 463
+RE E ER +ERE+ R++ +EKDRER+R++E D+D+E E E+D+++ERE
Sbjct: 115 DRETETER------QEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGE 168
Query: 464 SKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSP 523
++ ++ ++ +K R R + R+ RER R R + + + R +
Sbjct: 169 TERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKER 228
Query: 524 SPRSRNKKDKKREKERDHISERRE 547
+ +KD+ R+K D + R E
Sbjct: 229 DRERQREKDRDRQKAIDCVPGRWE 252
Score = 118 bits (295), Expect = 2e-26
Identities = 65/212 (30%), Positives = 126/212 (59%), Gaps = 29/212 (13%)
Query: 362 RERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKER 421
RER + R R R++ + KER +EKDRE E++R+++R++++ER + +DRD++R
Sbjct: 58 RERERQRERE---------RQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKR 108
Query: 422 EKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP 481
E+ ++D+E + ER+ E+E ++DR +EK++E+ +++E D+ +EI+ ++ +D++
Sbjct: 109 ERWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDRE----- 163
Query: 482 RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDH 541
R + R R RER+++R R R+ R R R+ +D+++E+E+D
Sbjct: 164 REMGETERYRDRERERQKQRETRRDRD--------RERQREKEDRERD-RDRQKEREKDR 214
Query: 542 ISER-----RERERSTSMRKSSNDRDGKEKLE 568
ER R++ER R+ DRD ++ ++
Sbjct: 215 YRERETGRDRDKERDRE-RQREKDRDRQKAID 245
Score = 114 bits (284), Expect = 4e-25
Identities = 60/206 (29%), Positives = 116/206 (56%), Gaps = 18/206 (8%)
Query: 387 KERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRD 446
+ER ++++RE++R+R KER +EK+R KDRD++R++DRE+ + +DR+R+RE+ DRD
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWG--DRD 115
Query: 447 KEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS 506
+E E E+ +E+ER++DR +E D +R++ ++ R + ++R R R +
Sbjct: 116 RETETERQEERERQRDRKREKDRERQRQREIGID------KDREIETEKDRDREREMGET 169
Query: 507 RSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEK 566
R + ++K + R R ++ +K ++ERD ++ + R++ DRD +
Sbjct: 170 ERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKE-- 227
Query: 567 LEKNSTSLKEKEHNKEPDSSVSKEVD 592
+++E +E D K +D
Sbjct: 228 --------RDRERQREKDRDRQKAID 245
Score = 107 bits (268), Expect = 3e-23
Identities = 57/191 (29%), Positives = 102/191 (53%), Gaps = 4/191 (2%)
Query: 261 VKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSS 320
V P + + +E E KR +E IE + + +R R R R + R
Sbjct: 52 VAPAIIRERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERW 111
Query: 321 KSHSRR---KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377
R +R + + R R R + R++ R+R K R E+ + R R +R
Sbjct: 112 GDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETER 171
Query: 378 KDTREKIKEKERVKEKDREKEREREKE-REKEKERGKNKDRDKEREKDREKDKEKDRERE 436
RE+ ++K+R +DR++ER+REKE RE++++R K +++D+ RE++ +D++K+R+RE
Sbjct: 172 YRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRE 231
Query: 437 REKEHEKDRDK 447
R++E ++DR K
Sbjct: 232 RQREKDRDRQK 242
Score = 90.9 bits (224), Expect = 3e-18
Identities = 52/191 (27%), Positives = 106/191 (55%), Gaps = 13/191 (6%)
Query: 413 KNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK 472
+ ++R +ERE+ R++ KE R RE+++E EKDRD+++++++++++ R++DR +E
Sbjct: 58 RERERQRERERQRKRAKE--RHREKDREIEKDRDRQRKRDRERQRWRDRDRKRE--RWGD 113
Query: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRRSR----SSSRSPRTSKTIKRKSSRSPSPRSR 528
+D+++ T + +R R ++R R+R R R T K R+ + R R
Sbjct: 114 RDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYR 173
Query: 529 NKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVS 588
+ ++++R+K+R+ RR+R+R K +RD + E+ +E+E ++ D
Sbjct: 174 D-RERERQKQRE---TRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERD 229
Query: 589 KEVD-DKDAPR 598
+E +KD R
Sbjct: 230 RERQREKDRDR 240
Score = 58.5 bits (140), Expect = 2e-08
Identities = 46/188 (24%), Positives = 84/188 (44%), Gaps = 53/188 (28%)
Query: 433 REREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRS 492
RERER++E E+ R + KE+ ++K++E EKDR D +RK+D R R
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDR----DRQRKRD--------------RERQ 99
Query: 493 SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER-----RE 547
R+R R+R R R T + +++ E+ER +R R+
Sbjct: 100 RWRDRDRKRERWGDRDRET------------------ETERQEERERQRDRKREKDRERQ 141
Query: 548 RERSTSMRK-----SSNDRDGKEKL-------EKNSTSLKEKEHNKEPDSSVSKEVDDKD 595
R+R + K + DRD + ++ ++ K++E ++ D +E +D++
Sbjct: 142 RQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKEDRE 201
Query: 596 APRTEENK 603
R + +
Sbjct: 202 RDRDRQKE 209
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/131 (22%), Positives = 55/131 (41%), Gaps = 2/131 (1%)
Query: 477 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536
SR P R R R+R+R + R + K R+ R + +D+KRE
Sbjct: 50 SRVAPAIIRERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRE 109
Query: 537 K--ERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 594
+ +RD +E +E R ++D + + ++ K++E E D +E+ +
Sbjct: 110 RWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGET 169
Query: 595 DAPRTEENKIQ 605
+ R E + Q
Sbjct: 170 ERYRDRERERQ 180
Score = 34.3 bits (77), Expect = 0.35
Identities = 31/133 (23%), Positives = 57/133 (42%), Gaps = 21/133 (15%)
Query: 478 RTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREK 537
+T P S+ + RS+ R+ R R + I R+ R + K+ K+R +
Sbjct: 25 QTRPVSWRLAMRSQIEDRDVL------ILRGSRVAPAIIRERERQRERERQRKRAKERHR 78
Query: 538 ERDHISE-------RRERERS-----TSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 585
E+D E +R+RER R+ DRD + + E+ ++++ +E D
Sbjct: 79 EKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKREKDR 138
Query: 586 SVSKEVD---DKD 595
++ + DKD
Sbjct: 139 ERQRQREIGIDKD 151
>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 129 bits (324), Expect = 8e-30
Identities = 103/345 (29%), Positives = 166/345 (48%), Gaps = 48/345 (13%)
Query: 257 NNAIVKPPEMTPQAAAKELE-EVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSK 315
N I K A+E + +V+ + + ++ +EP+ + K GRSRS S
Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSG--SS 513
Query: 316 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER------RKSRS 369
S SS S+SR + S S S++ S + RS SP +K+ SR R R+SRS
Sbjct: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRS 573
Query: 370 RSHSR--------------DKRKDTREKI-KEKERVKEKDREKEREREKEREKEKER-GK 413
RS+SR D+R+ R I +E+ R + RE+ R R + R++ R +
Sbjct: 574 RSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASR 633
Query: 414 NKDRDKER------------EKDREKDKEKDREREREKEHEKDR---DKEKEKEQDKEKE 458
++ RD+ + K + + KE++R++ER + +KDR DKE+E+EQDK KE
Sbjct: 634 SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE 693
Query: 459 REKDRSKEI------DEKRKKDKKSRTPPRSYNAS-RRSRSSSRERRRRRSRSSSRSPRT 511
++K K+ D ++K + RT RS + S + R SR+ ++ + S+
Sbjct: 694 KQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSG 753
Query: 512 SKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556
S + R SS SP S+ KK KK + R E+ +R + RK
Sbjct: 754 SDSSGRSSSESPG-SSKEKKAKKPKHSRSRSVEKSQRSGKKASRK 797
Score = 73.9 bits (180), Expect = 4e-13
Identities = 71/292 (24%), Positives = 117/292 (40%), Gaps = 51/292 (17%)
Query: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERV---KEKDREKEREREKEREKEKERGKNKDR 417
S + R R S ++ R +I++K+ KEK+++ +++ E EK++ K+
Sbjct: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455
Query: 418 DKEREKDRE-------KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK 470
++ K++ ++ + D E+++ + + K++ KEKE++
Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515
Query: 471 RKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS------RSPRTSKTIKRKSSRSPS 524
SRT S S S SSS R SRSSS S S TIK + SRS S
Sbjct: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575
Query: 525 --------------------PRSRNKKDKKREKERDHISER-----RERERSTSMRKSSN 559
+RN +++R + R ER R R+R T+ S
Sbjct: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635
Query: 560 DRDGKE----------KLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 601
RD ++ K+ KE+E KE S+ K+ KD R E
Sbjct: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687
Score = 69.3 bits (168), Expect = 1e-11
Identities = 68/332 (20%), Positives = 126/332 (37%), Gaps = 43/332 (12%)
Query: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDR---RRSKSPHKKRSKSRERRKSRSRSHSRDK 376
S+ + S+S R R RQK R+ K K E K ++ +++
Sbjct: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455
Query: 377 RKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436
+ ++ ++ ++ + + EK+R + + + + +EK+++
Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515
Query: 437 REKEHE--------------------KDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK- 475
R + ++K + RS I +R + +
Sbjct: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575
Query: 476 -------KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528
+S RRS +S ER RRR+RS SR R S++ R + + RSR
Sbjct: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635
Query: 529 NKKDKKREKERDHIS--------ERRERERSTSMRKSSNDRDGKEK---LEKNSTSLKEK 577
++ +K + +R ++S E +E+ER R S D+D K+K E+ KEK
Sbjct: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKE-RSRSIDKDRKKKDKEREREQDKRKEK 694
Query: 578 EHNKEPDSSVSKEVDDKDAPRTEENKIQHNGN 609
+ +E D S + D R E +G+
Sbjct: 695 QKREEKDFKFSSQDDRLKRKRESERTFSRSGS 726
Score = 37.7 bits (86), Expect = 0.032
Identities = 64/336 (19%), Positives = 118/336 (35%), Gaps = 62/336 (18%)
Query: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKER 405
++RR S + R +S + D K +E +++ +REK+++ EKER
Sbjct: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255
Query: 406 EKEKERGKNKDRDKEREKDRE---------KDKEKDREREREKEHEKDRDKEKEKEQDKE 456
E++R + ++K+ +D E + K E E + E+ + K
Sbjct: 256 -MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSP 314
Query: 457 KEREKDRSKEIDEKRK----------------------------KD---KKSRTPPRSYN 485
+E+ E+ E+ K KD K ++ P +
Sbjct: 315 VPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLA 374
Query: 486 ASRRSRS-----------SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK--- 531
S S S R R S S + ++ + + R +K
Sbjct: 375 QSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQ 434
Query: 532 ---DKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV- 587
DK+ E+E+ +ER +E + + K N E E + + EK+ +SV
Sbjct: 435 LLHDKQMEEEKQQ-TERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVL 493
Query: 588 --SKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKT 621
KE +K+ + +G+ N ST +
Sbjct: 494 EPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSS 529
>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 129 bits (324), Expect = 8e-30
Identities = 103/345 (29%), Positives = 166/345 (48%), Gaps = 48/345 (13%)
Query: 257 NNAIVKPPEMTPQAAAKELE-EVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSK 315
N I K A+E + +V+ + + ++ +EP+ + K GRSRS S
Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSG--SS 513
Query: 316 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER------RKSRS 369
S SS S+SR + S S S++ S + RS SP +K+ SR R R+SRS
Sbjct: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRS 573
Query: 370 RSHSR--------------DKRKDTREKI-KEKERVKEKDREKEREREKEREKEKER-GK 413
RS+SR D+R+ R I +E+ R + RE+ R R + R++ R +
Sbjct: 574 RSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASR 633
Query: 414 NKDRDKER------------EKDREKDKEKDREREREKEHEKDR---DKEKEKEQDKEKE 458
++ RD+ + K + + KE++R++ER + +KDR DKE+E+EQDK KE
Sbjct: 634 SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE 693
Query: 459 REKDRSKEI------DEKRKKDKKSRTPPRSYNAS-RRSRSSSRERRRRRSRSSSRSPRT 511
++K K+ D ++K + RT RS + S + R SR+ ++ + S+
Sbjct: 694 KQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSG 753
Query: 512 SKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556
S + R SS SP S+ KK KK + R E+ +R + RK
Sbjct: 754 SDSSGRSSSESPG-SSKEKKAKKPKHSRSRSVEKSQRSGKKASRK 797
Score = 73.9 bits (180), Expect = 4e-13
Identities = 71/292 (24%), Positives = 117/292 (40%), Gaps = 51/292 (17%)
Query: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERV---KEKDREKEREREKEREKEKERGKNKDR 417
S + R R S ++ R +I++K+ KEK+++ +++ E EK++ K+
Sbjct: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455
Query: 418 DKEREKDRE-------KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK 470
++ K++ ++ + D E+++ + + K++ KEKE++
Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515
Query: 471 RKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS------RSPRTSKTIKRKSSRSPS 524
SRT S S S SSS R SRSSS S S TIK + SRS S
Sbjct: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575
Query: 525 --------------------PRSRNKKDKKREKERDHISER-----RERERSTSMRKSSN 559
+RN +++R + R ER R R+R T+ S
Sbjct: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635
Query: 560 DRDGKE----------KLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 601
RD ++ K+ KE+E KE S+ K+ KD R E
Sbjct: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687
Score = 69.3 bits (168), Expect = 1e-11
Identities = 68/332 (20%), Positives = 126/332 (37%), Gaps = 43/332 (12%)
Query: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDR---RRSKSPHKKRSKSRERRKSRSRSHSRDK 376
S+ + S+S R R RQK R+ K K E K ++ +++
Sbjct: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455
Query: 377 RKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436
+ ++ ++ ++ + + EK+R + + + + +EK+++
Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515
Query: 437 REKEHE--------------------KDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK- 475
R + ++K + RS I +R + +
Sbjct: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575
Query: 476 -------KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528
+S RRS +S ER RRR+RS SR R S++ R + + RSR
Sbjct: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635
Query: 529 NKKDKKREKERDHIS--------ERRERERSTSMRKSSNDRDGKEK---LEKNSTSLKEK 577
++ +K + +R ++S E +E+ER R S D+D K+K E+ KEK
Sbjct: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKE-RSRSIDKDRKKKDKEREREQDKRKEK 694
Query: 578 EHNKEPDSSVSKEVDDKDAPRTEENKIQHNGN 609
+ +E D S + D R E +G+
Sbjct: 695 QKREEKDFKFSSQDDRLKRKRESERTFSRSGS 726
Score = 37.7 bits (86), Expect = 0.032
Identities = 64/336 (19%), Positives = 118/336 (35%), Gaps = 62/336 (18%)
Query: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKER 405
++RR S + R +S + D K +E +++ +REK+++ EKER
Sbjct: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255
Query: 406 EKEKERGKNKDRDKEREKDRE---------KDKEKDREREREKEHEKDRDKEKEKEQDKE 456
E++R + ++K+ +D E + K E E + E+ + K
Sbjct: 256 -MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSP 314
Query: 457 KEREKDRSKEIDEKRK----------------------------KD---KKSRTPPRSYN 485
+E+ E+ E+ K KD K ++ P +
Sbjct: 315 VPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLA 374
Query: 486 ASRRSRS-----------SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK--- 531
S S S R R S S + ++ + + R +K
Sbjct: 375 QSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQ 434
Query: 532 ---DKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV- 587
DK+ E+E+ +ER +E + + K N E E + + EK+ +SV
Sbjct: 435 LLHDKQMEEEKQQ-TERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVL 493
Query: 588 --SKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKT 621
KE +K+ + +G+ N ST +
Sbjct: 494 EPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSS 529
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 127 bits (318), Expect = 4e-29
Identities = 77/237 (32%), Positives = 130/237 (54%), Gaps = 21/237 (8%)
Query: 316 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRD 375
SR++ K ++ + H S+ + S +K RR + +KR + RE+ + R R
Sbjct: 7 SRAAVKLNTELQMVSCSHISKPCTQRESERKKERRER---EKRKREREKERKRERGKKEK 63
Query: 376 KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDR-E 434
K++ RE+ KE+ER K K+REK+R+ +E+E+ K + + K R++++ RE+ K+K+R E
Sbjct: 64 KKRKKRERGKERER-KRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKE 122
Query: 435 RERE--KEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRS 492
RERE + E+ R K ++K++ KE++REK+R K +++K+ K+ R R N R+ R
Sbjct: 123 RERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERN--RKERK 180
Query: 493 SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERE 549
RER+ RR R R K + KKD+K +++ D R RE
Sbjct: 181 KERERKERRERKKERKKERRK------------KKERKKDRKTDRQTDSQVFRPLRE 225
Score = 126 bits (317), Expect = 5e-29
Identities = 67/202 (33%), Positives = 118/202 (58%), Gaps = 8/202 (3%)
Query: 385 KEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER-EREKEHEK 443
+E ER KE+ ++R+RE+E+E+++ERGK ++K++ K RE+ KE++R+R EREK+ ++
Sbjct: 32 RESERKKERREREKRKREREKERKRERGK---KEKKKRKKRERGKERERKRKEREKQRKE 88
Query: 444 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASR-RSRSSSRERRRRRS 502
R+KE+ K + ++K+RE+ + + K+KK++K R R R + ++RR+ R
Sbjct: 89 RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148
Query: 503 RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRD 562
R R R K KRK R RN+K++K+E+ER ER++ + +K +D
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKD 208
Query: 563 GKEKLEKNS---TSLKEKEHNK 581
K + +S L+E N+
Sbjct: 209 RKTDRQTDSQVFRPLRESAFNR 230
Score = 122 bits (307), Expect = 8e-28
Identities = 67/181 (37%), Positives = 111/181 (61%), Gaps = 11/181 (6%)
Query: 296 ESGKSNER----KGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRS 351
ES + ER K R R R + R + R+KR + K R R ++K+RR
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92
Query: 352 KSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERE--REKEREKEK 409
+ +K+ K + RK R R R K+K+ +E+ +E ++ +E+ R+K R+ R KER++EK
Sbjct: 93 ERRKRKKEKKKRERKQRGR-RERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK 151
Query: 410 ERGKNKDRDKEREKD-REKDKE---KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 465
ERGK + + K+R+K+ REK +E K+R++ERE++ ++R KE++KE+ K+KER+KDR
Sbjct: 152 ERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKT 211
Query: 466 E 466
+
Sbjct: 212 D 212
Score = 121 bits (303), Expect = 2e-27
Identities = 64/188 (34%), Positives = 120/188 (63%), Gaps = 7/188 (3%)
Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 353
+P + + +ERK R R + R + R K+ + K + R + R R++ + R K
Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKR-KEREKQ 85
Query: 354 PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK 413
++R K R +RK + R K++ RE+ K+KER KE++RE ++ RE++R+K +++ +
Sbjct: 86 RKERREKERRKRKKEKKKRER-KQRGRRERKKKKER-KERERENKQRRERKRKKRRKKKR 143
Query: 414 NKDRDKEREKD-REKDKEKDREREREKEHEKDR-DKEKEKEQDKEKEREKDRSKEIDEK- 470
K+R +E+E+ RE+ ++K ++ EREK+ E++R +++KE+E+ + +ER+K+R KE +K
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKK 203
Query: 471 -RKKDKKS 477
RKKD+K+
Sbjct: 204 ERKKDRKT 211
Score = 112 bits (280), Expect = 1e-24
Identities = 65/203 (32%), Positives = 112/203 (55%), Gaps = 11/203 (5%)
Query: 260 IVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS 319
I KP KE E KR RE + + E GK ++K + + +
Sbjct: 25 ISKPCTQRESERKKERREREKRKREREK----ERKRERGKKEKKKRKKRERGKERERKRK 80
Query: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKD 379
+ R++R + + R R + + +K R R + KK K RER + R R KR
Sbjct: 81 EREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKR-- 138
Query: 380 TREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREK 439
R+K + KER +EK+R K RER++++ K++ER K ++R++ K+R+K++E+ RER+K
Sbjct: 139 -RKKKRRKERKREKERGK-RERKRKKRKKEEREKKRERNR---KERKKERERKERRERKK 193
Query: 440 EHEKDRDKEKEKEQDKEKEREKD 462
E +K+R K+KE+++D++ +R+ D
Sbjct: 194 ERKKERRKKKERKKDRKTDRQTD 216
Score = 111 bits (278), Expect = 2e-24
Identities = 58/193 (30%), Positives = 116/193 (60%), Gaps = 4/193 (2%)
Query: 314 SKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHS 373
S+ + + +RKR + K R R + +++ +R +++ K RE+++ R
Sbjct: 34 SERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE 93
Query: 374 RDKRKDTREKIKEKERVK-EKDREKER-EREKEREKEKERGKNKDRDKEREKDREKDKEK 431
R KRK ++K + K+R + E+ ++KER ERE+E ++ +ER + K R K+R K+R+++KE+
Sbjct: 94 RRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKER 153
Query: 432 -DREREREKEHEKDRDKEKEK-EQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
RER+R+K +++R+K++E+ ++++KERE+ +E ++RKK+++ + + + R
Sbjct: 154 GKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDR 213
Query: 490 SRSSSRERRRRRS 502
S R R S
Sbjct: 214 QTDSQVFRPLRES 226
Score = 91.3 bits (225), Expect = 2e-18
Identities = 55/187 (29%), Positives = 99/187 (52%), Gaps = 13/187 (6%)
Query: 425 REKDKEKDREREREK---EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP 481
RE +++K+R REREK E EK+R +E+ K ++K+K ++++R KE + KRK+ +K R
Sbjct: 32 RESERKKER-REREKRKREREKERKRERGK-KEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 482 RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDH 541
R +R + + R++R R + + K +R++ + + + ++ KKR KER
Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKR 149
Query: 542 ISERRERERSTSMRKSS--------NDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDD 593
ER +RER RK N ++ K++ E+ ++KE KE ++ D
Sbjct: 150 EKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDR 209
Query: 594 KDAPRTE 600
K +T+
Sbjct: 210 KTDRQTD 216
Score = 90.9 bits (224), Expect = 3e-18
Identities = 44/132 (33%), Positives = 78/132 (59%), Gaps = 4/132 (3%)
Query: 302 ERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKS 361
ER+ R + K + K RR+R + K R + R ++++R+R K KKR K
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGRRERKKKKER-KERERENKQRRERKRKKRRKKKRRKE 146
Query: 362 RERRKSRSRSHSRDKRKDTREKIKEKER---VKEKDREKEREREKEREKEKERGKNKDRD 418
R+R K R + + K++ E+ K++ER ++K+RE++ RE+++E++KER K K+R
Sbjct: 147 RKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERK 206
Query: 419 KEREKDREKDKE 430
K+R+ DR+ D +
Sbjct: 207 KDRKTDRQTDSQ 218
Score = 82.4 bits (202), Expect = 1e-15
Identities = 49/181 (27%), Positives = 90/181 (49%), Gaps = 8/181 (4%)
Query: 440 EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 499
+ E +R KE+ + + +++EREK+R +E +K KK +K R + R+ R R+ RR
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 500 RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 559
+ R + K K++ + R R KK +++E+ER++ +RRER+R RK
Sbjct: 91 EKERR-----KRKKEKKKRERKQRGRRERKKKKERKEREREN-KQRRERKRK-KRRKKKR 143
Query: 560 DRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLST 619
++ K + E+ K K+ KE + +E + K+ + E K + + +E
Sbjct: 144 RKERKREKERGKRERKRKKRKKE-EREKKRERNRKERKKERERKERRERKKERKKERRKK 202
Query: 620 K 620
K
Sbjct: 203 K 203
Score = 63.2 bits (152), Expect = 7e-10
Identities = 46/189 (24%), Positives = 85/189 (44%), Gaps = 37/189 (19%)
Query: 436 EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495
+RE E +K+R + +++++++EKER+++R K+ +KRKK R R R
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKK---------------RERGKER 75
Query: 496 ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD--HISERRERERSTS 553
ER+R+ R R R R K+ +KR+KE+ +R RER
Sbjct: 76 ERKRKE-REKQRKER-----------------REKERRKRKKEKKKRERKQRGRRERKKK 117
Query: 554 MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLN 613
+ +R+ K++ E+ ++K+ KE KE ++ R + K + + N
Sbjct: 118 KERKERERENKQRRERKRKKRRKKKRRKE--RKREKERGKRERKRKKRKKEEREKKRERN 175
Query: 614 EENLSTKTE 622
+ + E
Sbjct: 176 RKERKKERE 184
Score = 52.8 bits (125), Expect = 1e-06
Identities = 32/147 (21%), Positives = 60/147 (40%)
Query: 476 KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKR 535
K T S R R+R R + R R + K K++ R R +++K+R
Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQR 86
Query: 536 EKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKD 595
++ R+ +R++E+ RK R+ K+K E+ + K+ + K+ K+
Sbjct: 87 KERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE 146
Query: 596 APRTEENKIQHNGNCQLNEENLSTKTE 622
R +E + + +E K E
Sbjct: 147 RKREKERGKRERKRKKRKKEEREKKRE 173
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/105 (26%), Positives = 44/105 (41%), Gaps = 9/105 (8%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332
+E E +R R+ + E + ER G R R + K K R ++ + K
Sbjct: 123 RERENKQRRERKRKKRRKKKRRKERKREKER-GKRERKRKKRKKEEREKKRERNRKERKK 181
Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377
R R R R +K+R+ K+R K +ER+K R D +
Sbjct: 182 ERERKERRER--KKERK------KERRKKKERKKDRKTDRQTDSQ 218
Score = 41.2 bits (95), Expect = 0.003
Identities = 25/113 (22%), Positives = 52/113 (46%), Gaps = 1/113 (0%)
Query: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDR 561
S S P T + +RK R + + +++K+R++ER E+++R++ ++ R
Sbjct: 21 SCSHISKPCTQRESERKKERREREKRKREREKERKRERGK-KEKKKRKKRERGKERERKR 79
Query: 562 DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNE 614
+EK K + ++ KE K+ ++ + +E K + N Q E
Sbjct: 80 KEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRE 132
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 125 bits (313), Expect = 2e-28
Identities = 71/231 (30%), Positives = 129/231 (55%), Gaps = 30/231 (12%)
Query: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK 385
R+R + R R+K+RR + +KR + +ER++ R + + +RK + K
Sbjct: 41 REREIETRKEGKKERESERKKERREREK--RKREREKERKRERGKKEKKGERKKEERERK 98
Query: 386 EKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR 445
++ R KE +E+E+ K++EK KERG+ KERE+ E+ +E+ +ERER+KE +R
Sbjct: 99 KRRREKENKEGEEKEKRKKKEK-KERGRTSKEGKERERKEERKREERKERERKKE---ER 154
Query: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 505
+KE+E+++ K++ER++ KE +E+++K++K R + +R+ R RER+ RR R
Sbjct: 155 EKERERKERKKRERKQVGEKE-EERKEKERKER---KKRERNRKERKKERERKERRERKK 210
Query: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556
R + K+++K+E+++D + RE+ER RK
Sbjct: 211 ER--------------------KKKEERKKERQKDRQTNWREKERGKRERK 241
Score = 123 bits (309), Expect = 4e-28
Identities = 72/214 (33%), Positives = 128/214 (59%), Gaps = 15/214 (7%)
Query: 368 RSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREK 427
R R + RK+ +++ +E ER KE+ ++R+RE+E+E+++ERGK KE++ +R+K
Sbjct: 39 REREREIETRKEGKKE-RESERKKERREREKRKREREKERKRERGK-----KEKKGERKK 92
Query: 428 DKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNAS 487
++ + ++R REKE+++ +KEK K+++K KER + SKE E+ +K+++ R +
Sbjct: 93 EERERKKRRREKENKEGEEKEKRKKKEK-KERGRT-SKEGKERERKEERKREERKERERK 150
Query: 488 RRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRE 547
+ R RER+ R+ R + + K K + R RN+K++K+E+ER ERRE
Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERER---KERRE 207
Query: 548 RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNK 581
R++ RK +R KE+ + T+ +EKE K
Sbjct: 208 RKKE---RKKKEERK-KERQKDRQTNWREKERGK 237
Score = 119 bits (299), Expect = 6e-27
Identities = 67/208 (32%), Positives = 114/208 (54%), Gaps = 7/208 (3%)
Query: 277 EVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSR 336
E+ +R RE ++ E ES + ER+ R R K R + +K + K
Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96
Query: 337 SHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDRE 396
R R ++ K KK+ K R S+ K + RE+ KE+ER KE +RE
Sbjct: 97 RKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE-ERE 155
Query: 397 KEREREKEREKE-KERGKNKDRDKEREKDREKDKE---KDREREREKEHEKDRDKEKEKE 452
KERER++ +++E K+ G+ ++ KE+E+ K +E K+R++ERE++ ++R KE++K+
Sbjct: 156 KERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKK 215
Query: 453 QDKEKEREKDRSKEIDEKR--KKDKKSR 478
++++KER+KDR EK K+++K R
Sbjct: 216 EERKKERQKDRQTNWREKERGKRERKER 243
Score = 117 bits (293), Expect = 3e-26
Identities = 60/213 (28%), Positives = 117/213 (54%), Gaps = 5/213 (2%)
Query: 296 ESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPH 355
+ G +E + TR + + +S +++R + + R R + R R++ ++ K
Sbjct: 31 QPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGER 90
Query: 356 KKRSKSRE-RRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 414
KK + R+ RR+ + +K K +++ KE+ R ++ +E+ER+ E++RE+ KER +
Sbjct: 91 KKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERK 150
Query: 415 K-DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKK 473
K +R+KERE+ K +E+ + E+E+E ++ KE++K + KER+K+R ++ +RKK
Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKK 210
Query: 474 DKK---SRTPPRSYNASRRSRSSSRERRRRRSR 503
++K R R + R R +R R+ R
Sbjct: 211 ERKKKEERKKERQKDRQTNWREKERGKRERKER 243
Score = 115 bits (287), Expect = 2e-25
Identities = 55/207 (26%), Positives = 120/207 (57%), Gaps = 5/207 (2%)
Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSK 352
E E ++G + R R K R + R R++ + + R + + ++++R R K
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKK 99
Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK---EREKEK 409
+K +K E ++ R + +++ + ++E KE+ER +E+ RE+ +ERE+ EREKE+
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKERGRTSKEG-KERERKEERKREERKERERKKEEREKER 158
Query: 410 ERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE 469
ER + K R++++ ++E+++++ +ER+K ++++KE+E+ + +ER+K+R K+ +
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEER 218
Query: 470 KRKKDKKSRTPPRSYNASRRSRSSSRE 496
K+++ K +T R +R R ++
Sbjct: 219 KKERQKDRQTNWREKERGKRERKERKK 245
Score = 114 bits (285), Expect = 3e-25
Identities = 67/223 (30%), Positives = 122/223 (54%), Gaps = 15/223 (6%)
Query: 381 REKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE 440
+ +I+E+ER E +E ++ERE ER+KE+ +EREK R++++EK+R+RER K+
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKER---------REREK-RKREREKERKRERGKK 84
Query: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRR 500
+K K++E+E+ K + ++++ E EKRKK +K S R R R+R R
Sbjct: 85 EKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREER 144
Query: 501 RSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSND 560
+ R + R + +++ + + K+++++EKER ER++RER+ RK +
Sbjct: 145 KERERKKEEREKERERKERKKRERKQVGEKEEERKEKER---KERKKRERNRKERK--KE 199
Query: 561 RDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603
R+ KE+ E+ K++E KE +K+ + E +
Sbjct: 200 RERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKE 242
Score = 102 bits (253), Expect = 1e-21
Identities = 65/191 (34%), Positives = 103/191 (53%), Gaps = 18/191 (9%)
Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHS------RR 326
KE E KR RE + + E GK E+KG R + K R K + +R
Sbjct: 61 KERREREKRKREREK----ERKRERGKK-EKKGERKKEERERKKRRREKENKEGEEKEKR 115
Query: 327 KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKE 386
K+ + K R R+ + R++ R + K+R + +E R+ R KR+ + KE
Sbjct: 116 KKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKE 175
Query: 387 KERVKEKDREKERERE---KEREKEKERGKNKDRDKEREKDREKDKEKDRERE---REKE 440
+ER KEK+R++ ++RE KER+KE+ER + ++R KER+K E+ KE+ ++R+ REKE
Sbjct: 176 EER-KEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKE 234
Query: 441 HEKDRDKEKEK 451
K KE++K
Sbjct: 235 RGKRERKERKK 245
Score = 92.0 bits (227), Expect = 1e-18
Identities = 61/198 (30%), Positives = 109/198 (55%), Gaps = 8/198 (4%)
Query: 417 RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK 476
R++ERE + K+ +K+RE ER+KE ++R+K K +E++KE++RE+ + KE +RKK+++
Sbjct: 39 REREREIETRKEGKKERESERKKER-REREKRK-REREKERKRERGK-KEKKGERKKEER 95
Query: 477 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR-SRNKKDKKR 535
R R ++ + R+++ + R+ + K +RK R R R +K ++R
Sbjct: 96 ERKKRRREKENKEGEEKEK-RKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Query: 536 EKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKD 595
EKER+ ER++RER + + +R KE+ E+ KE KE + +E K+
Sbjct: 155 EKERER-KERKKRERK-QVGEKEEERKEKERKERKKRERNRKERKKERERKERRE-RKKE 211
Query: 596 APRTEENKIQHNGNCQLN 613
+ EE K + + Q N
Sbjct: 212 RKKKEERKKERQKDRQTN 229
Score = 74.7 bits (182), Expect = 2e-13
Identities = 53/200 (26%), Positives = 90/200 (45%), Gaps = 33/200 (16%)
Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484
RE+++E + +E +KE E +R KE+ + + +++EREK+R +E +K KK ++ +
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKK------ 92
Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHIS- 543
RER++RR ++ + K+ KK +KER S
Sbjct: 93 --------EERERKKRRREKENKEGE----------------EKEKRKKKEKKERGRTSK 128
Query: 544 ERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV-SKEVDDKDAPRTEEN 602
E +ERER RK ++ + K E+ + KE K V KE + K+ R E
Sbjct: 129 EGKERERKEE-RKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERK 187
Query: 603 KIQHNGNCQLNEENLSTKTE 622
K + N + E + E
Sbjct: 188 KRERNRKERKKERERKERRE 207
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/135 (24%), Positives = 60/135 (44%), Gaps = 8/135 (5%)
Query: 476 KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKR 535
K T + + S S+ ++ + R R T K K++ R ++ +KR
Sbjct: 12 KLNTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKR 71
Query: 536 EKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPD-------SSVS 588
E+E++ ER ++E+ +K +R K + EK + +EKE K+ + S
Sbjct: 72 EREKERKRERGKKEKKGERKKEERERK-KRRREKENKEGEEKEKRKKKEKKERGRTSKEG 130
Query: 589 KEVDDKDAPRTEENK 603
KE + K+ + EE K
Sbjct: 131 KERERKEERKREERK 145
Score = 43.1 bits (100), Expect = 8e-04
Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 5/105 (4%)
Query: 262 KPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSK 321
K E + KE E ++ RE + + E K ERK + R R + + +
Sbjct: 145 KERERKKEEREKERERKERKKRERKQ---VGEKEEERKEKERKERKKRERNRKERKKERE 201
Query: 322 SHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRK 366
RR+R K R + R + RQKDR+ + ++ + R+ RK
Sbjct: 202 RKERRERK--KERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
sapiens]
Length = 434
Score = 119 bits (299), Expect = 6e-27
Identities = 78/249 (31%), Positives = 123/249 (49%), Gaps = 18/249 (7%)
Query: 310 SHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRS 369
S R K + S+ S R+ H SRS +RSR R++ H+ RS+S+E R+ S
Sbjct: 17 SPDRDKKKEQSEV-SVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHES 75
Query: 370 RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDK 429
+ S K K KE K ++R E ++R K KER ++ R R + RE+
Sbjct: 76 KDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRER-- 133
Query: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
+ R R RE++ + R +E++K + + +ER+K RS+ + KR+ +SR+ R R
Sbjct: 134 -RHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSR-----HR 187
Query: 490 SRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP---RSRN------KKDKKREKERD 540
R+ SR R R RSR + + R SR+PSP R RN + +R +
Sbjct: 188 HRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAK 247
Query: 541 HISERRERE 549
+ E+RE+E
Sbjct: 248 KLQEQREKE 256
Score = 111 bits (277), Expect = 2e-24
Identities = 70/201 (34%), Positives = 110/201 (54%), Gaps = 10/201 (4%)
Query: 371 SHSRDKRKDTRE-KIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDK 429
S RDK+K+ E + + R + R RE++R+ + E K++ R + +E R + K
Sbjct: 17 SPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESK 76
Query: 430 EKDREREREKEH-EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASR 488
+K ++ + +EH +K+ +K +E+ E +DR K K +K + R+ RS + R
Sbjct: 77 DKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKR---KERKSSRGRSHSRSRSRER 133
Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRER 548
R RS SRER++ RSRS R S++ +RK SRS RSR +K + R + R S R R
Sbjct: 134 RHRSRSRERKKSRSRSRERKKSRSRSRERKKSRS---RSRERKRRIRSRSRSR-SRHRHR 189
Query: 549 ERSTSMRKSSNDRDGKEKLEK 569
RS S R S RD K+++EK
Sbjct: 190 TRSRS-RTRSRSRDRKKRIEK 209
Score = 110 bits (274), Expect = 5e-24
Identities = 72/267 (26%), Positives = 126/267 (47%), Gaps = 25/267 (9%)
Query: 264 PEMTPQAAAKELEE----VMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS 319
PE T K+ E+ V R + S + E + ++ +G + RS +RSK
Sbjct: 13 PEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKE--- 69
Query: 320 SKSHSRRKRSQSKHRSRSHN---RSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDK 376
+ H + +S KH+S HN S + ++R S + R K +ER+ SR RSHSR +
Sbjct: 70 GRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSR 129
Query: 377 RKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436
++ R R + RER+K R + +ER K++ R +ER+K R + +E+ R R
Sbjct: 130 SRERRH------------RSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKR-RI 176
Query: 437 REKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK-SRTP-PRSYNASRRSRSSS 494
R + + R + + + + + + R +DR K I++ R+ + SRTP P + + +
Sbjct: 177 RSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQ 236
Query: 495 RERRRRRSRSSSRSPRTSKTIKRKSSR 521
RR R+ + K + K +
Sbjct: 237 EALARRLERAKKLQEQREKEMVEKQKQ 263
Score = 102 bits (254), Expect = 1e-21
Identities = 58/189 (30%), Positives = 101/189 (53%), Gaps = 10/189 (5%)
Query: 296 ESGKSNERKGGRSRSHTRSKSR----SSSKSHSRRKRSQSKH-RSRSHNRSRSRQKDRRR 350
+S K ++ + + H+ K R SS R KR + K R RSH+RSRSR++ R R
Sbjct: 78 KSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRER-RHR 136
Query: 351 SKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKE 410
S+S +K+S+SR R + +SRS SR+++K + K R++ + R + R R + R + +
Sbjct: 137 SRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRT 196
Query: 411 RGKNKDRDKEREKDREKDKEKDRERE----REKEHEKDRDKEKEKEQDKEKEREKDRSKE 466
R +++DR K EK R + R R + D + + ++ K+ ++ R KE
Sbjct: 197 RSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKE 256
Query: 467 IDEKRKKDK 475
+ EK+K+ +
Sbjct: 257 MVEKQKQQE 265
Score = 59.3 bits (142), Expect = 1e-08
Identities = 48/177 (27%), Positives = 75/177 (42%), Gaps = 20/177 (11%)
Query: 430 EKDREREREKEHEKDRDKEKEKEQDKEKER------EKDRSKEIDEKRKKDKKSRTPPRS 483
+ +R+ ++ DRDK+KE+ + R + RS+ + KRK D + R
Sbjct: 5 DTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGR----- 59
Query: 484 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR-----NKKDKKREKE 538
RSRS S+E RR S+ S S+ K S R R N +D+ + KE
Sbjct: 60 ---KHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKE 116
Query: 539 RDHISER-RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 594
R R R RS R S R+ K+ ++ K + ++E S S+ + K
Sbjct: 117 RKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERK 173
Score = 32.3 bits (72), Expect = 1.3
Identities = 17/82 (20%), Positives = 33/82 (40%)
Query: 528 RNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV 587
+ D+ ++KE+ +S + R S R+ K K + + + +KE
Sbjct: 15 KTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHE 74
Query: 588 SKEVDDKDAPRTEENKIQHNGN 609
SK+ K E N +H+ +
Sbjct: 75 SKDKSSKKHKSEEHNDKEHSSD 96
>gi|20070262 TNF receptor-associated factor 3 interacting protein 1
isoform 1 [Homo sapiens]
Length = 691
Score = 116 bits (290), Expect = 7e-26
Identities = 92/331 (27%), Positives = 163/331 (49%), Gaps = 26/331 (7%)
Query: 297 SGKSNERKGGRS-RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRS---K 352
+G+ E KG S S ++ + + R ++ R + + RS +DR++ K
Sbjct: 130 AGEKGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELK 189
Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERV---KEKDR-EKEREREKEREKE 408
K R K +++ K++ +R R+ RE+ K + R ++KDR +ER+R+ ER+KE
Sbjct: 190 EDRKPREKDKDKEKAKENGGNRH-REGERERAKARARPDNERQKDRGNRERDRDSERKKE 248
Query: 409 KER----GKNKD--RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK- 461
ER GK K+ RD++RE+DR+K K++DR R + EH D D+EK +E DK +++
Sbjct: 249 TERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSAS 308
Query: 462 --DRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKS 519
+ SK++ + KD K+ T + ++R S+S + + +RRS++S R I KS
Sbjct: 309 SGEMSKKLSDGTFKDSKAET--ETEISTRASKSLTTKTSKRRSKNSVEG-RKEDNISAKS 365
Query: 520 SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579
S N + +E I + STS+ ++ E ++ N T ++ +
Sbjct: 366 LDSIVSGINN--EPNQETTTSEIGTKEANINSTSISDDNSASLRCENIQPNPTEKQKGDS 423
Query: 580 NKEPDSSVSKEVDDK-DAPRTEE--NKIQHN 607
+ + DK + P T E N++ N
Sbjct: 424 TSDAEGDAGPAGQDKSEVPETPEIPNELSSN 454
Score = 96.3 bits (238), Expect = 8e-20
Identities = 83/366 (22%), Positives = 146/366 (39%), Gaps = 84/366 (22%)
Query: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358
K+ + R +T + + K S + + K + + R + KD+ ++K R
Sbjct: 152 KNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELKEDRKPREKDKDKEKAKENGGNR 211
Query: 359 SKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 418
+ ER ++++R+ ++R+ R +E+DR+ ER++E ER+ E + K + RD
Sbjct: 212 HREGERERAKARARPDNERQKDRGN-------RERDRDSERKKETERKSEGGKEKERLRD 264
Query: 419 KEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK---DRSKEIDEKRKKDK 475
++RE+DR+K K++DR R + EH D D+EK +E DK +++ + SK++ + KD
Sbjct: 265 RDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSASSGEMSKKLSDGTFKDS 324
Query: 476 KSRTPPR-SYNASRRSRSSSRERR-------RRRSRSSSRS--------------PRTSK 513
K+ T S AS+ + + +RR R+ S++S T+
Sbjct: 325 KAETETEISTRASKSLTTKTSKRRSKNSVEGRKEDNISAKSLDSIVSGINNEPNQETTTS 384
Query: 514 TIKRKSSR-------------------SPSPRSRNKKDKKREKERD-------------- 540
I K + P+P + K D + E D
Sbjct: 385 EIGTKEANINSTSISDDNSASLRCENIQPNPTEKQKGDSTSDAEGDAGPAGQDKSEVPET 444
Query: 541 -----HISERRER--------------ERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNK 581
+S R +R SM DR G K N + N+
Sbjct: 445 PEIPNELSSNIRRIPRPGSARPAPPRVKRQDSMEALQMDRSGSGKTVSNVITESHNSDNE 504
Query: 582 EPDSSV 587
E D V
Sbjct: 505 EDDQFV 510
Score = 87.8 bits (216), Expect = 3e-17
Identities = 65/261 (24%), Positives = 113/261 (43%), Gaps = 37/261 (14%)
Query: 366 KSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDR 425
K R+ SR + D + +E+ RV + ++ KER ++R + KE K+
Sbjct: 137 KGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDR-----KQKEELKED 191
Query: 426 EKDKEKDREREREKEHEKDRDKEKEKEQDK-----EKEREKDRSKEIDEKRKKDKKSRTP 480
K +EKD+++E+ KE+ +R +E E+E+ K + ER+KDR + R ++K T
Sbjct: 192 RKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNR-ERDRDSERKKETE 250
Query: 481 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD 540
+S + R R+R R R + R R K + D REK R+
Sbjct: 251 RKSEGGKEKERLRDRDRERDRDKGKDRDRRRVK------------NGEHSWDLDREKNRE 298
Query: 541 HISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600
H ++ S M K +D K+ + T + + SK + K + R
Sbjct: 299 HDKPEKKSASSGEMSKKLSDGTFKDSKAETETEISTR---------ASKSLTTKTSKRRS 349
Query: 601 ENKIQHNGNCQLNEENLSTKT 621
+N ++ E+N+S K+
Sbjct: 350 KNSVEGR-----KEDNISAKS 365
Score = 34.7 bits (78), Expect = 0.27
Identities = 42/184 (22%), Positives = 76/184 (41%), Gaps = 15/184 (8%)
Query: 290 SAAIEPESGKSN--ERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKD 347
SA++ E+ + N E++ G S S + + + S + S N R +
Sbjct: 403 SASLRCENIQPNPTEKQKGDSTSDAEGDAGPAGQDKSEVPETPEIPNELSSNIRRIPRPG 462
Query: 348 RRRSKSPHKKRSKSRER-RKSRS-----------RSHSRDKRKDTREKIKEKERVKEKDR 395
R P KR S E + RS SH+ D +D + ++ ++ E
Sbjct: 463 SARPAPPRVKRQDSMEALQMDRSGSGKTVSNVITESHNSDNEEDDQFVVEAAPQLSEMS- 521
Query: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDK 455
E E E E+E++ G + E +KD EK ++ + E+E+ + K+++ K
Sbjct: 522 EIEMVTAVELEEEEKHGGLVKKILETKKDYEKLQQSPKPGEKERSLFESAWKKEKDIVSK 581
Query: 456 EKER 459
E E+
Sbjct: 582 EIEK 585
Score = 33.1 bits (74), Expect = 0.79
Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 13/130 (10%)
Query: 483 SYNASRRSRSSSRERRRRRSRSSSRSPR-TSKTIKRKSSRSPSPRSRNKKDK--KREKER 539
S +A RR + + + R+ +SRS +K ++ + SR +N +D+ KER
Sbjct: 121 SDDAVRRVLAGEKGEVKGRASLTSRSQELDNKNVREEESRV----HKNTEDRGDAEIKER 176
Query: 540 DHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLK---EKEHNK---EPDSSVSKEVDD 593
+R+++E RK KEK ++N + E+E K PD+ K+ +
Sbjct: 177 STSRDRKQKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGN 236
Query: 594 KDAPRTEENK 603
++ R E K
Sbjct: 237 RERDRDSERK 246
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 116 bits (290), Expect = 7e-26
Identities = 61/202 (30%), Positives = 121/202 (59%), Gaps = 6/202 (2%)
Query: 325 RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKI 384
+++R Q S + R+R R+++ R + ++++ E+ K +++ + E+I
Sbjct: 446 KQRRRQQSEISAAVERARKRREEEER-RMEEQRKAACAEKLKRLDEKLGILEKQPSPEEI 504
Query: 385 KEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKD 444
+E+ER KE++REKE E+E+E+E+EKER K+++R +E+EK+ EK++EK RE E+E++ EK+
Sbjct: 505 REREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKE 564
Query: 445 RDKEKEKEQDKEKEREKDRSKEID-EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 503
++ E++KE++KE ++ K++ KE + EK ++ + + PR N E S
Sbjct: 565 KELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESE----NSC 620
Query: 504 SSSRSPRTSKTIKRKSSRSPSP 525
+ P ++ +S + +P
Sbjct: 621 NKEEEPVFTRQDSNRSEKEATP 642
Score = 111 bits (277), Expect = 2e-24
Identities = 79/277 (28%), Positives = 137/277 (49%), Gaps = 23/277 (8%)
Query: 264 PEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSH 323
P + Q A E +E+ K+ R QS ISAA+E + K E + R ++ K
Sbjct: 431 PFPSKQQVADE-DEIWKQRRRQQSEISAAVE-RARKRREEEERRMEEQRKAACAEKLKRL 488
Query: 324 SRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK 383
+ K S R R R+K+R R K K++ + RE +E+
Sbjct: 489 DEKLGILEKQPSPEEIREREREKEREREKELEKEQEQERE-----------------KER 531
Query: 384 IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEK 443
K++ER +EK++E E+E+EK+RE EKER + K+++ ER+K++EK+ +K +E+E+E E EK
Sbjct: 532 EKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEK 591
Query: 444 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 503
+R+K +EK + +E E K+ E K P + S RS +
Sbjct: 592 EREKLEEKIEPREPNLEPMVEKQ--ESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEP 649
Query: 504 SSSRSPRTS--KTIKRKSSRSPSPRSRNKKDKKREKE 538
S PR + ++ +S PR + ++++ ++++
Sbjct: 650 ESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQ 686
Score = 82.0 bits (201), Expect = 1e-15
Identities = 50/209 (23%), Positives = 100/209 (47%), Gaps = 4/209 (1%)
Query: 378 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER 437
K R + E E+ R++ E E+ E++++ + + EK +K+ E R
Sbjct: 446 KQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIR 505
Query: 438 EKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER 497
E+E EK+R++EKE E+++E+EREK+R K+ + +++K+K+ + R +E+
Sbjct: 506 EREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEK 565
Query: 498 RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKS 557
R + + + K +++ +K + RE + + E++E E S + +
Sbjct: 566 ELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEE 625
Query: 558 S-NDRDGKEKLEKNSTSLKEKEHNKEPDS 585
R + EK +T + H EP+S
Sbjct: 626 PVFTRQDSNRSEKEATPV---VHETEPES 651
Score = 63.2 bits (152), Expect = 7e-10
Identities = 63/361 (17%), Positives = 159/361 (44%), Gaps = 39/361 (10%)
Query: 264 PEMTPQAAAKELEEVMKRVREA-QSFISAAIEPE-----SGKSNERKGGRSRSHTRSKSR 317
P + + KEL++ EA + + A +E + + ++ +G S S+ +
Sbjct: 294 PSILSASELKELDKFDNLDAEADEGWAGAQMEVDYTEQLNFSDDDEQGSNSPKENNSEDQ 353
Query: 318 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRS-------- 369
S S + + ++ S + + S+ + +K P+ K + R + S
Sbjct: 354 GSKASENNENKKETDEVSNTKSSSQIPAQPSV-AKVPYGKGPSFNQERGTSSHLPPPPKL 412
Query: 370 --RSHSRDKRKDTREK---IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD 424
+ H R+ + K++V ++D ++ R ++ E + + R +E E+
Sbjct: 413 LAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERR 472
Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484
E+ ++ + ++ EK EK+ ++ +ERE+++ +E +++ +K+++
Sbjct: 473 MEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQE-------- 524
Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE 544
+ R RE+ R R + + + +R+ + + ++++EKE++ + +
Sbjct: 525 ----QEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKE-LQK 579
Query: 545 RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDD----KDAPRTE 600
+E+E+ + K + EK+E +L+ +E ++S +KE + +D+ R+E
Sbjct: 580 MKEQEKECELEKEREKLE--EKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSE 637
Query: 601 E 601
+
Sbjct: 638 K 638
Score = 57.8 bits (138), Expect = 3e-08
Identities = 76/326 (23%), Positives = 124/326 (38%), Gaps = 36/326 (11%)
Query: 306 GRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR 365
GR R S+ RS S+ R R R H R + +D + ++ H R+R
Sbjct: 1187 GRGRGEYYSRGRSYRGSYGGRGRG-----GRGHTRDYPQYRDNK-PRAEHIPSGPLRQRE 1240
Query: 366 KSRSRSHSRD------KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDK 419
+S +RS S D +R+ + + E +K+ + + K +ER +NK K
Sbjct: 1241 ESETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVK 1300
Query: 420 EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 479
+ + + R EK + +D DK K K + + R + R
Sbjct: 1301 PHSSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTF------RRGGRD 1354
Query: 480 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS------PRSRNKKDK 533
P R SR S+ RR R + +PR S+ K + P P + +K+
Sbjct: 1355 P-----GGRPSRPST--LRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFIPIAADKRPP 1407
Query: 534 KREKERDHISERRERERSTSMRKSSNDRDGK-EKLEKNSTSLKEKEHNKEPDSSVSKEVD 592
K E++ D ER R+R T R D+ + +L + + K E P + V
Sbjct: 1408 KFERKFDPARERPRRQRPT--RPPRQDKPPRFRRLREREAASKSNEVVAVPTNGTVNNVA 1465
Query: 593 DKDAPRTEENKIQHNGNCQLNEENLS 618
+ P I N L+ +N S
Sbjct: 1466 QE--PVNTLGDISGNKTPDLSNQNSS 1489
Score = 52.4 bits (124), Expect = 1e-06
Identities = 49/272 (18%), Positives = 108/272 (39%), Gaps = 20/272 (7%)
Query: 347 DRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKERE 406
D + S SP K + S ++ S ++ K D K ++ + + K
Sbjct: 338 DEQGSNSP--KENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPS 395
Query: 407 KEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKE 466
+ERG + + ++ DR+ + ++ E + K+R + +S E
Sbjct: 396 FNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQS-E 454
Query: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKS--SRSPS 524
I ++ +K R ERR R ++ + + + ++ + PS
Sbjct: 455 ISAAVERARKRR--------------EEEERRMEEQRKAACAEKLKRLDEKLGILEKQPS 500
Query: 525 PRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPD 584
P ++++++E+ER+ E+ + + R+ +R +++ E K++E KE
Sbjct: 501 PEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERK 560
Query: 585 SSVSKEVDDKDAPRTEENKI-QHNGNCQLNEE 615
KE++ + E K+ + C+L +E
Sbjct: 561 QEKEKELERQKEKEKELQKMKEQEKECELEKE 592
Score = 51.6 bits (122), Expect = 2e-06
Identities = 59/254 (23%), Positives = 107/254 (42%), Gaps = 42/254 (16%)
Query: 262 KPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKS-RSSS 320
+P + T A +E E+V Q I+AA E + +H ++ R SS
Sbjct: 816 EPQQATTPKATEEPEDVRSEAALDQEQITAAYSVEHNQLE--------AHPKADFIRESS 867
Query: 321 KSHSRRKRSQSKHRSRSHNRSRSRQK------DRRRSKSPHKKRSKSRERRKSRSRSHSR 374
++ ++ S+S R H+ + Q D++ +P ++R + E + SR RS S
Sbjct: 868 EAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEERISAVESQPSRKRSVSH 927
Query: 375 DKR-----------------KDTREKIKEKERVKEKDREKERE---REKEREKEKE--RG 412
K T I KE ++ + + ++E R E K ++ +
Sbjct: 928 GSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIRSSEGPKPEKVYKS 987
Query: 413 KNKDRDKEREKDREKDKEKDRERER----EKEHEKDRDKEKEKEQDKEKER-EKDRSKEI 467
K++ R R +++ DR R +K +D +E+E+ ++KE E+ EK K +
Sbjct: 988 KSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKAEKVTEKVV 1047
Query: 468 DEKRKKDKKSRTPP 481
+ K +KK PP
Sbjct: 1048 VKPEKTEKKDLPPP 1061
Score = 40.0 bits (92), Expect = 0.006
Identities = 77/401 (19%), Positives = 139/401 (34%), Gaps = 87/401 (21%)
Query: 265 EMTPQAAAKELEEVMKRVREAQSFI---SAAIEPESGKSNERKGGRSRSHTRSKSRSSSK 321
E ++ + + E V KR R+ S S E S K + KG + R +++ K
Sbjct: 1241 ESETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVK 1300
Query: 322 SHSRRK-----RSQSKHRSRSHNRSRSRQKD---------RRRSKSPHKKRSKSRERRKS 367
HS K R ++ + + R + K RR ++ + R S
Sbjct: 1301 PHSSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRDPGGRPS 1360
Query: 368 RSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK-------------EREKEKERGKN 414
R + R +D + ++ E K +D E R E+ ER+ + R +
Sbjct: 1361 RPSTLRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFIPIAADKRPPKFERKFDPARERP 1420
Query: 415 KDRDKEREKDREKDKEKDRERERE---KEHE----------------------------- 442
+ + R ++K R RERE K +E
Sbjct: 1421 RRQRPTRPPRQDKPPRFRRLREREAASKSNEVVAVPTNGTVNNVAQEPVNTLGDISGNKT 1480
Query: 443 KDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP--------------PRSYNASR 488
D + +Q E+ S + +E+R++D+K P ++
Sbjct: 1481 PDLSNQNSSDQANEEWETASESSDFNERRERDEKKNADLNAQTVVKVGENVLPPKREIAK 1540
Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIK--RKSSRSPSPRSRNKKDKKREKE-------- 538
RS SS R R+ R ++ P++ + R RS P K+ ++
Sbjct: 1541 RSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNERRSGPPSKSGKRGPFDDQPAGTTGVDL 1600
Query: 539 -RDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKE 578
+ +E + + +K+S D GK++ + K KE
Sbjct: 1601 INGSSAHHQEGVPNGTGQKNSKDSTGKKREDPKPGPKKPKE 1641
Score = 33.9 bits (76), Expect = 0.46
Identities = 28/131 (21%), Positives = 50/131 (38%), Gaps = 15/131 (11%)
Query: 422 EKDREKDKEKDREREREKEHEKDRDKEKEKEQD-------KEKEREKDRSKEIDEKRKKD 474
+++R E R+R H + ++ ++++ K R D + I+ +K
Sbjct: 908 QEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKP 967
Query: 475 KKSR--------TPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 526
KK P + Y + +R R RR + R R S IK+ R
Sbjct: 968 KKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEE 1027
Query: 527 SRNKKDKKREK 537
+K+K+ EK
Sbjct: 1028 REQRKEKEGEK 1038
>gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
sapiens]
Length = 820
Score = 115 bits (287), Expect = 2e-25
Identities = 85/274 (31%), Positives = 142/274 (51%), Gaps = 36/274 (13%)
Query: 315 KSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSR 374
K R +S S RKRS R+ +R R R +DR+ S S +KR +SR+RR+ SRS SR
Sbjct: 9 KDRDASPSKEERKRS------RTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSR 62
Query: 375 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDR- 433
+R K E+ER R KERER+KER++ K K++DRDK+ + R+KD+++
Sbjct: 63 -----SRSKSAERER-----RHKERERDKERDRNK---KDRDRDKDGHR-RDKDRKRSSL 108
Query: 434 --EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE---KRKKDKKSRTPPRSYNASR 488
R ++ + KDRD +K++E + ++ K + ++E K+K ++++ P+ + +
Sbjct: 109 SPGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAE 168
Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRER 548
R E +RR + R + +RK + R + +E+ER ER ER
Sbjct: 169 R----EAEALKRRQQEVEERQRMLEE-ERKKRKQFQDLGRKMLEDPQERERRERRERMER 223
Query: 549 ERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE 582
E + + D +G++K+ + KE KE
Sbjct: 224 ETN-----GNEDEEGRQKIREEKDKSKELHAIKE 252
Score = 92.8 bits (229), Expect = 8e-19
Identities = 73/282 (25%), Positives = 127/282 (45%), Gaps = 22/282 (7%)
Query: 313 RSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR-KSRSR 370
R +SR+ + R R R S + R +RSR R++ RS+S + +S RERR K R R
Sbjct: 20 RKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKERER 79
Query: 371 SHSRDKRKDTREKIKEKERVKEKDREKER---EREKEREKEKERGKNKDRDKEREKDREK 427
RD+ K R++ K+ R ++KDR++ R K+ + K+R KD + E + K
Sbjct: 80 DKERDRNKKDRDRDKDGHR-RDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEHGDKKPK 138
Query: 428 DKEKDREREREKEHEKDRDKEKEK---EQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484
+ E K+ ++ + K K + ++E E K R +E++E+++ ++ R + +
Sbjct: 139 AQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQF 198
Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE 544
R + R RR R T+ + R + +++K + KE I E
Sbjct: 199 QDLGRKMLEDPQERERRERRERMERETN------GNEDEEGRQKIREEKDKSKELHAIKE 252
Query: 545 R-------RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579
R R R R + RK + D E + L ++ H
Sbjct: 253 RYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERH 294
Score = 84.7 bits (208), Expect = 2e-16
Identities = 81/363 (22%), Positives = 158/363 (43%), Gaps = 44/363 (12%)
Query: 272 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQS 331
A +E KR R + +S S +RK RSR R SRS S+S S+ +
Sbjct: 13 ASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERER 72
Query: 332 KHRSRSHNRSRSR-QKDRRRSKSPH------KKRSKSRERRKSRSRSHSRDKRKDTREKI 384
+H+ R ++ R R +KDR R K H K+ S S R K RD +KD ++
Sbjct: 73 RHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEH 132
Query: 385 KEK----------ERVKEKDREKERERE----KEREKEKERGKNKDRD-KEREKDREKDK 429
+K E + +K E+E E + + E+E E K + ++ +ER++ E+++
Sbjct: 133 GDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEER 192
Query: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
+K ++ + + +E+E+ + +E+ + E +E R+K ++ + + +A +
Sbjct: 193 KKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREEKDKSKELHAIKE 252
Query: 490 SRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNK----------------KDK 533
++RRR + R +S +P + + K +
Sbjct: 253 RYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQ 312
Query: 534 KREKER---DHISERR---ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV 587
KRE+ R D + +RR E+E+ + + ++ K++ + S K+ + + D +
Sbjct: 313 KREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRI 372
Query: 588 SKE 590
+E
Sbjct: 373 FRE 375
Score = 82.4 bits (202), Expect = 1e-15
Identities = 52/201 (25%), Positives = 95/201 (47%), Gaps = 18/201 (8%)
Query: 410 ERGKNKDRD-----KEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDK--EKEREKD 462
E KDRD +ER++ R D+E+DR+R+R+ KDR + + +++ + + R +
Sbjct: 4 ELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRS 63
Query: 463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522
RSK + +R+ ++ R R N R R RR + + SS SP K K
Sbjct: 64 RSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFK------ 117
Query: 523 PSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE 582
SR +D K+++E +H +++ + + S+ + + +E+ E L + E E
Sbjct: 118 ----SRKDRDSKKDEEDEH-GDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAE 172
Query: 583 PDSSVSKEVDDKDAPRTEENK 603
+EV+++ EE K
Sbjct: 173 ALKRRQQEVEERQRMLEEERK 193
Score = 70.1 bits (170), Expect = 6e-12
Identities = 51/191 (26%), Positives = 88/191 (46%), Gaps = 17/191 (8%)
Query: 438 EKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER 497
E +KDRD KE E+ RS+ D +R +D+ ++ P + R R R
Sbjct: 4 ELADKKDRDASPSKE-------ERKRSRTPDRERDRDRDRKSSPS------KDRKRHRSR 50
Query: 498 RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKS 557
RRR S SRS SK+ +R+ R + + K++++RD RR+++R S
Sbjct: 51 DRRRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSP 110
Query: 558 SNDRDGKEKLEKNSTSLKEKEH-NKEPDS---SVSKEVDDKDAPRTEENKIQHNGNCQLN 613
+D K + +++S +E EH +K+P + S+ + + K A E K + +
Sbjct: 111 GRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAERE 170
Query: 614 EENLSTKTEAV 624
E L + + V
Sbjct: 171 AEALKRRQQEV 181
Score = 43.1 bits (100), Expect = 8e-04
Identities = 53/264 (20%), Positives = 99/264 (37%), Gaps = 17/264 (6%)
Query: 271 AAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ 330
A +E E + +R +E + E + ERK + K + RR+R +
Sbjct: 167 AEREAEALKRRQQEVE-------ERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRE 219
Query: 331 SKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER-----RKSRSRSHSRDKRKDTREKIK 385
R + N ++ R K K+ +ER +K R H D++
Sbjct: 220 RMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDAS 279
Query: 386 EKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR 445
E + KER + + + G + + K + D + R EKE E+ R
Sbjct: 280 EDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEAR 339
Query: 446 DKEKEKEQDKEKEREKDRS-KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRS 504
++ K++ K++ ++ S K++DE +D + S ++ R +
Sbjct: 340 LRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSIT----TKGGKIPNPIRSWKD 395
Query: 505 SSRSPRTSKTIKRKSSRSPSPRSR 528
SS P + I + + P+P R
Sbjct: 396 SSLPPHILEVIDKCGYKEPTPIQR 419
>gi|213385278 TNF receptor-associated factor 3 interacting protein 1
isoform 2 [Homo sapiens]
Length = 625
Score = 114 bits (284), Expect = 4e-25
Identities = 89/321 (27%), Positives = 155/321 (48%), Gaps = 36/321 (11%)
Query: 297 SGKSNERKGGRS-RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRS---K 352
+G+ E KG S S ++ + + R ++ R + + RS +DR++ K
Sbjct: 130 AGEKGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELK 189
Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERV---KEKDR-EKEREREKEREKE 408
K R K +++ K++ +R R+ RE+ K + R ++KDR +ER+R+ ER+KE
Sbjct: 190 EDRKPREKDKDKEKAKENGGNRH-REGERERAKARARPDNERQKDRGNRERDRDSERKKE 248
Query: 409 KER----GKNKD--RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK- 461
ER GK K+ RD++RE+DR+K K++DR R + EH D D+EK +E DK +++
Sbjct: 249 TERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSAS 308
Query: 462 --DRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKS 519
+ SK++ + KD K+ T + ++R S+S + + +RRS++S TS +
Sbjct: 309 SGEMSKKLSDGTFKDSKAET--ETEISTRASKSLTTKTSKRRSKNSVEGDSTSDA---EG 363
Query: 520 SRSPSPRSRNKKDKKREKERDHISERR-------------ERERSTSMRKSSNDRDGKEK 566
P+ + +++ + E + S R +R SM DR G K
Sbjct: 364 DAGPAGQDKSEVPETPEIPNELSSNIRRIPRPGSARPAPPRVKRQDSMEALQMDRSGSGK 423
Query: 567 LEKNSTSLKEKEHNKEPDSSV 587
N + N+E D V
Sbjct: 424 TVSNVITESHNSDNEEDDQFV 444
Score = 100 bits (248), Expect = 5e-21
Identities = 79/326 (24%), Positives = 155/326 (47%), Gaps = 22/326 (6%)
Query: 309 RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSR 368
+ + ++ +S+S ++ + SR H + R + K+RS SR+R++
Sbjct: 133 KGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDR------GDAEIKERSTSRDRKQKE 186
Query: 369 SRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN---KDR-DKEREKD 424
R R EK K+KE+ KE + RE E+ER K + R N KDR ++ER++D
Sbjct: 187 ELKEDRKPR----EKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERDRD 242
Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK----EIDEKRKKDKKSRTP 480
E+ KE +R+ E KE E+ RD+++E+++DK K+R++ R K D R+K+++ P
Sbjct: 243 SERKKETERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKP 302
Query: 481 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRN--KKDKKREKE 538
+ +S + + S++ + + +++ K ++++ RS+N + D + E
Sbjct: 303 EKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSVEGDSTSDAE 362
Query: 539 RDHISERRERERSTSMRKSSNDRDGK-EKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAP 597
D +++ + N+ ++ + ++ K DS + ++D +
Sbjct: 363 GDAGPAGQDKSEVPETPEIPNELSSNIRRIPRPGSARPAPPRVKRQDSMEALQMDRSGSG 422
Query: 598 RTEENKIQHNGNCQLNEENLSTKTEA 623
+T N I + N NEE+ EA
Sbjct: 423 KTVSNVITESHNSD-NEEDDQFVVEA 447
Score = 33.1 bits (74), Expect = 0.79
Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 13/130 (10%)
Query: 483 SYNASRRSRSSSRERRRRRSRSSSRSPR-TSKTIKRKSSRSPSPRSRNKKDK--KREKER 539
S +A RR + + + R+ +SRS +K ++ + SR +N +D+ KER
Sbjct: 121 SDDAVRRVLAGEKGEVKGRASLTSRSQELDNKNVREEESRV----HKNTEDRGDAEIKER 176
Query: 540 DHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLK---EKEHNK---EPDSSVSKEVDD 593
+R+++E RK KEK ++N + E+E K PD+ K+ +
Sbjct: 177 STSRDRKQKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGN 236
Query: 594 KDAPRTEENK 603
++ R E K
Sbjct: 237 RERDRDSERK 246
Score = 33.1 bits (74), Expect = 0.79
Identities = 49/224 (21%), Positives = 86/224 (38%), Gaps = 16/224 (7%)
Query: 248 DRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGR 307
D+P K + S+ + K +K E R ++S + + S S E G
Sbjct: 300 DKPEKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSVE---GD 356
Query: 308 SRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER-RK 366
S S + + + S + S N R + R P KR S E +
Sbjct: 357 STSDAEGDAGPAGQDKSEVPETPEIPNELSSNIRRIPRPGSARPAPPRVKRQDSMEALQM 416
Query: 367 SRS-----------RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 415
RS SH+ D +D + ++ ++ E E E E E+E++ G
Sbjct: 417 DRSGSGKTVSNVITESHNSDNEEDDQFVVEAAPQLSEMS-EIEMVTAVELEEEEKHGGLV 475
Query: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKER 459
+ E +KD EK ++ + E+E+ + K+++ KE E+
Sbjct: 476 KKILETKKDYEKLQQSPKPGEKERSLFESAWKKEKDIVSKEIEK 519
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 113 bits (283), Expect = 5e-25
Identities = 117/427 (27%), Positives = 182/427 (42%), Gaps = 106/427 (24%)
Query: 296 ESGKSNERKGGRSRSHTRSKSRSSS-----KSHSRRKRSQSKHRSRSHNRS--------- 341
E G+ +E+ +RS TRS S + +KRS+S+ + R+ +RS
Sbjct: 146 EEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGI 205
Query: 342 --------RSRQKDRRRSKSPHKKRSKSRERRKSRS---RSHSRDK----RKDTREKIKE 386
RS+ K+R++SKSP K+ + RKS+S R S++K R T +K+K
Sbjct: 206 EIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKI 265
Query: 387 KERVKEKDREKE----------------------------REREKERE-KEKERGKNKDR 417
+++ K KDR+K R R KER+ K E K K
Sbjct: 266 EDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKP 325
Query: 418 DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKS 477
K KD KE +R R R K +DK + + RS ++++R K KS
Sbjct: 326 IKSPSKDASSGKE-NRSPSRRPGRSPKRRSLSPKPRDKSR---RSRSPLLNDRRSKQSKS 381
Query: 478 RTPPRSYNASRRSRSSSRERRR---------------------RRSRSSSRSP------- 509
P R+ + RR++S S ER+R RR RS SP
Sbjct: 382 --PSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPT 439
Query: 510 -RTSKTIKRKSSRSP-----SPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDG 563
R S++ R+ SRSP SPR R++ ++R++ R S R R RS R+ +
Sbjct: 440 RRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKV 499
Query: 564 KEKLEKNSTS--LKEKEHNKEPDSSVSKEVDDKDAPR-TEENKIQHNGNCQ-----LNEE 615
KE K S S +K ++ + D+ +V+++D E+ +IQ Q +
Sbjct: 500 KEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDS 559
Query: 616 NLSTKTE 622
N+S +E
Sbjct: 560 NMSVPSE 566
Score = 97.1 bits (240), Expect = 4e-20
Identities = 93/369 (25%), Positives = 165/369 (44%), Gaps = 43/369 (11%)
Query: 255 HSNNAIVKPPEMTPQAAAKELE----EVMKRVREAQSFISAAIEPESGKSNERKG-GRSR 309
H I+ + + AK + +++ + + ++ I A ++ E + + G G
Sbjct: 78 HKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLIL 137
Query: 310 SHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRS 369
S S + H +++++ +RS + + S + + +K KKRSKSR + ++R
Sbjct: 138 QGYESGSEEEGEIH---EKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRH 194
Query: 370 RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDK 429
RS + K K E +KEK R + KER+K K K R K +++ R+
Sbjct: 195 RSDKK-KSKGGIEIVKEKTT---------RSKSKERKKSKSPSK---RSKSQDQARKSKS 241
Query: 430 EKDREREREK-EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD--KKSRTPPRSYNA 486
R R +EK + +K K +DK K +++ +S I+E R +D KKSR+P
Sbjct: 242 PTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGK 301
Query: 487 SRRSRSSSRERRRRRSRS------------SSRSPRTSKTIKRKSSRSPSPRSRNKK--D 532
S+ RS S+ER+ +RS + + S + +++ R+ RSP RS + K D
Sbjct: 302 SKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRD 361
Query: 533 KKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEP-----DSSV 587
K R +++RR ++ + R S R K + + E+ P D +
Sbjct: 362 KSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDIL 421
Query: 588 SKEVDDKDA 596
S+ KDA
Sbjct: 422 SRRERSKDA 430
Score = 89.4 bits (220), Expect = 9e-18
Identities = 82/337 (24%), Positives = 137/337 (40%), Gaps = 36/337 (10%)
Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 353
+PE +N K + S+ +S +K HSR K+ + KHRS+ S ++D+ + K
Sbjct: 12 QPEMEDANSEKSINEENGEVSEDQSQNK-HSRHKKKKHKHRSKHKKHKHSSEEDKDK-KH 69
Query: 354 PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK-EREKEKERG 412
HK + K +R++ S R K+ + + +D EK+R K E + E G
Sbjct: 70 KHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALL--EDLEKQRALIKAELDNELMEG 127
Query: 413 K-----------------------NKDRDKEREKDREKDKEKDREREREKEHEKDRDKEK 449
K K R+ R R + E K K R K +
Sbjct: 128 KVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSR 187
Query: 450 EKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP 509
KE+ + + +K I+ ++K +S++ R + S RS S+++ R+ + R
Sbjct: 188 SKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRR 247
Query: 510 RTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERS------TSMRKSSNDR-- 561
K K +S + +K K K+ I+E R R+R +R S DR
Sbjct: 248 SQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRS 307
Query: 562 DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPR 598
KE+ K S + KEK+ K P S +++ R
Sbjct: 308 RSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSR 344
Score = 72.8 bits (177), Expect = 9e-13
Identities = 72/308 (23%), Positives = 135/308 (43%), Gaps = 39/308 (12%)
Query: 340 RSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKER 399
R + +D KS +++ + E + S + K+ R K K+ + E+D++K+
Sbjct: 10 REQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKH 69
Query: 400 EREKEREKEKERGKNKDRDKEREKDREKDKEKD----REREREK---EHEKDRDKEKEKE 452
+ + + +K K + DKE ++ K D + E+++ + E D + + K
Sbjct: 70 KHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKV 129
Query: 453 QD------KEKEREKDRSKEIDEKRKKDKKSRTPPRS-----------YNASRRSRSSSR 495
Q + E + EI EK + +S T S +RS+S S+
Sbjct: 130 QSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSK 189
Query: 496 ERRRRRSRSSSRSPRTSKTIKRKSSRSPS-PRSRNKKDKKREKERDHISERRERERSTSM 554
ER R RS +S + +K K++RS S R ++K KR K +D + + +S ++
Sbjct: 190 ERTRHRS-DKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQD----QARKSKSPTL 244
Query: 555 RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNE 614
R+ S ++ GK ++ T K K +K SK D K +P E++ + G +
Sbjct: 245 RRRSQEKIGK---ARSPTDDKVKIEDK------SKSKDRKKSPIINESRSRDRGKKSRSP 295
Query: 615 ENLSTKTE 622
+L K++
Sbjct: 296 VDLRGKSK 303
Score = 67.0 bits (162), Expect = 5e-11
Identities = 65/275 (23%), Positives = 124/275 (45%), Gaps = 27/275 (9%)
Query: 301 NERKGGRSRSHTRSKS---RSSSKSHSRRKRSQSKHRSRSHNRSRSR-----QKDRRRSK 352
N+R+ +S+S +R+ S R+ S+S RKR + + R S R+R R +++R +
Sbjct: 372 NDRRSKQSKSPSRTLSPGRRAKSRS-LERKRREPERRRLSSPRTRPRDDILSRRERSKDA 430
Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERG 412
SP + S +R R +S R SR + +R + + +DR + R R + R + + RG
Sbjct: 431 SPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGR-RSRSRLRRRSRSRG 489
Query: 413 KNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK 472
+ R + + K+ DK K E K ++ + ++ D E+E E+ + E+R+
Sbjct: 490 GRRRRSRSKVKE---DKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEE----ALIEQRR 542
Query: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD 532
+++ Y A + S E +S + +RSP ++R ++
Sbjct: 543 IQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAA----------DV 592
Query: 533 KKREKERDHISERRERERSTSMRKSSNDRDGKEKL 567
K+ E+E E + + M N+ ++KL
Sbjct: 593 KEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKL 627
Score = 53.9 bits (128), Expect = 4e-07
Identities = 61/234 (26%), Positives = 102/234 (43%), Gaps = 29/234 (12%)
Query: 245 MFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERK 304
+ DR K + S + + P +A ++ LE +R E + S P + R+
Sbjct: 370 LLNDRRSKQSKSPSRTLSPGR---RAKSRSLER-KRREPERRRLSSPRTRPRDDILSRRE 425
Query: 305 GGRSRSHTRSKSRSSSKSHS-RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK----KRS 359
RSK S S R+RS+S R RS + R + RRRS+SP + +RS
Sbjct: 426 --------RSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRS 477
Query: 360 KSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDK 419
+SR RR+SRSR +R+ +R K+KE +K + E K ++ +D D
Sbjct: 478 RSRLRRRSRSRG---GRRRRSRSKVKE-----DKFKGSLSEGMKVEQESSSDDNLEDFDV 529
Query: 420 EREKDREKDKEKDRER----EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE 469
E E + +++ +R ++ K +D + E + + RS D+
Sbjct: 530 EEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDD 583
>gi|52426743 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 112 bits (280), Expect = 1e-24
Identities = 81/251 (32%), Positives = 131/251 (52%), Gaps = 26/251 (10%)
Query: 366 KSRSRSHSRDKRKDTREKIKEK-ERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD 424
+SR H K+ KIK E +KEK R++ E +++ +KE+ + ++R+KERE++
Sbjct: 205 QSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERE 264
Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD-KKSRTPPRS 483
RE+ + K R E E+E E+ RD+E+ K + + + R R+ + R +D K+SR+
Sbjct: 265 REERERKRRREEEEREKERARDRERRK-RSRSRSRHSSRTSDRRCSRSRDHKRSRS---- 319
Query: 484 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD-KKREKERDHI 542
R R SR R RRRSRS RS R ++ R RS +SR++K K R K RD
Sbjct: 320 -----RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRS---KSRDRKSYKHRSKSRDRE 371
Query: 543 SERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEEN 602
+R+ +E+ ++ S+D+ K+S +E E ++ SKE D K+
Sbjct: 372 QDRKSKEKE---KRGSDDK-------KSSVKSGSREKQSEDTNTESKESDTKNEVNGTSE 421
Query: 603 KIQHNGNCQLN 613
I+ G+ Q N
Sbjct: 422 DIKSEGDTQSN 432
Score = 104 bits (259), Expect = 3e-22
Identities = 64/208 (30%), Positives = 111/208 (53%), Gaps = 16/208 (7%)
Query: 269 QAAAKELEEVMKR-----------VREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317
+A +EL+E +++ +E Q E E + + R R K R
Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283
Query: 318 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377
+ + +R RS+S+H SR+ +R SR +D +RS+S ++RS+SR+RR RSRSH R +R
Sbjct: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR--RSRSHDRSER 341
Query: 378 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER 437
K R + +++ R K +DR+ + R K R++E++R K+K+++K R D +K K RE+
Sbjct: 342 KH-RSRSRDRRRSKSRDRKSYKHRSKSRDREQDR-KSKEKEK-RGSDDKKSSVKSGSREK 398
Query: 438 EKEHEKDRDKEKEKEQDKEKEREKDRSK 465
+ E KE + + + E +S+
Sbjct: 399 QSEDTNTESKESDTKNEVNGTSEDIKSE 426
Score = 102 bits (253), Expect = 1e-21
Identities = 60/230 (26%), Positives = 112/230 (48%), Gaps = 15/230 (6%)
Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS------RSHNRSRSRQKD 347
+ +S + G + + + K+ RKR++ R + R ++++
Sbjct: 203 DAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERE 262
Query: 348 RRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 407
R R + K+R + ER K R+R R++RK +R + + R DR R R+ +R +
Sbjct: 263 REREERERKRRREEEEREKERARD--RERRKRSRSRSRHSSRTS--DRRCSRSRDHKRSR 318
Query: 408 EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR-SKE 466
+ER +++ RD+ R + ++ + K R R R++ K RD++ K + K ++RE+DR SKE
Sbjct: 319 SRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKE 378
Query: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIK 516
+++ DKKS + SR +S + S + + TS+ IK
Sbjct: 379 KEKRGSDDKKSSVK----SGSREKQSEDTNTESKESDTKNEVNGTSEDIK 424
Score = 97.8 bits (242), Expect = 3e-20
Identities = 58/229 (25%), Positives = 107/229 (46%), Gaps = 29/229 (12%)
Query: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK 403
++K R+R++ P + +E+++ R R++ ++ RE+ K R +E++REKER R++
Sbjct: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERER---KRRREEEEREKERARDR 287
Query: 404 EREKE-KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462
ER K + R ++ R +R R +D ++ R RER + +DR + + ++ + K R +
Sbjct: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS 347
Query: 463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522
R R RS SR+R+ + RS SR + K K R
Sbjct: 348 RD------------------------RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383
Query: 523 PSPRSRNKKDKKREKE-RDHISERRERERSTSMRKSSNDRDGKEKLEKN 570
+ + K REK+ D +E +E + + +S D + + N
Sbjct: 384 SDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
Score = 67.4 bits (163), Expect = 4e-11
Identities = 53/160 (33%), Positives = 76/160 (47%), Gaps = 19/160 (11%)
Query: 277 EVMKRVREAQSFISAAIEPESGKSNERKGGRSR----SHTRSKSRSSSKSHSRRKRSQSK 332
E KR R S + +S + K RSR S +R + R S+SH RS+ K
Sbjct: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRR--SRSHD---RSERK 342
Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392
HRSRS +R RS+ +DR+ +K RSKSR+R + R + K K+ R +K VK
Sbjct: 343 HRSRSRDRRRSKSRDRK----SYKHRSKSRDREQDR-----KSKEKEKRGSDDKKSSVKS 393
Query: 393 KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD 432
REK+ E KE + KN+ + E D + +
Sbjct: 394 GSREKQSEDTNTESKESDT-KNEVNGTSEDIKSEGDTQSN 432
>gi|19923485 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 112 bits (280), Expect = 1e-24
Identities = 81/251 (32%), Positives = 131/251 (52%), Gaps = 26/251 (10%)
Query: 366 KSRSRSHSRDKRKDTREKIKEK-ERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD 424
+SR H K+ KIK E +KEK R++ E +++ +KE+ + ++R+KERE++
Sbjct: 205 QSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERE 264
Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD-KKSRTPPRS 483
RE+ + K R E E+E E+ RD+E+ K + + + R R+ + R +D K+SR+
Sbjct: 265 REERERKRRREEEEREKERARDRERRK-RSRSRSRHSSRTSDRRCSRSRDHKRSRS---- 319
Query: 484 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD-KKREKERDHI 542
R R SR R RRRSRS RS R ++ R RS +SR++K K R K RD
Sbjct: 320 -----RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRS---KSRDRKSYKHRSKSRDRE 371
Query: 543 SERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEEN 602
+R+ +E+ ++ S+D+ K+S +E E ++ SKE D K+
Sbjct: 372 QDRKSKEKE---KRGSDDK-------KSSVKSGSREKQSEDTNTESKESDTKNEVNGTSE 421
Query: 603 KIQHNGNCQLN 613
I+ G+ Q N
Sbjct: 422 DIKSEGDTQSN 432
Score = 104 bits (259), Expect = 3e-22
Identities = 64/208 (30%), Positives = 111/208 (53%), Gaps = 16/208 (7%)
Query: 269 QAAAKELEEVMKR-----------VREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317
+A +EL+E +++ +E Q E E + + R R K R
Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283
Query: 318 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377
+ + +R RS+S+H SR+ +R SR +D +RS+S ++RS+SR+RR RSRSH R +R
Sbjct: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR--RSRSHDRSER 341
Query: 378 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER 437
K R + +++ R K +DR+ + R K R++E++R K+K+++K R D +K K RE+
Sbjct: 342 KH-RSRSRDRRRSKSRDRKSYKHRSKSRDREQDR-KSKEKEK-RGSDDKKSSVKSGSREK 398
Query: 438 EKEHEKDRDKEKEKEQDKEKEREKDRSK 465
+ E KE + + + E +S+
Sbjct: 399 QSEDTNTESKESDTKNEVNGTSEDIKSE 426
Score = 102 bits (253), Expect = 1e-21
Identities = 60/230 (26%), Positives = 112/230 (48%), Gaps = 15/230 (6%)
Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS------RSHNRSRSRQKD 347
+ +S + G + + + K+ RKR++ R + R ++++
Sbjct: 203 DAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERE 262
Query: 348 RRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 407
R R + K+R + ER K R+R R++RK +R + + R DR R R+ +R +
Sbjct: 263 REREERERKRRREEEEREKERARD--RERRKRSRSRSRHSSRTS--DRRCSRSRDHKRSR 318
Query: 408 EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR-SKE 466
+ER +++ RD+ R + ++ + K R R R++ K RD++ K + K ++RE+DR SKE
Sbjct: 319 SRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKE 378
Query: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIK 516
+++ DKKS + SR +S + S + + TS+ IK
Sbjct: 379 KEKRGSDDKKSSVK----SGSREKQSEDTNTESKESDTKNEVNGTSEDIK 424
Score = 97.8 bits (242), Expect = 3e-20
Identities = 58/229 (25%), Positives = 107/229 (46%), Gaps = 29/229 (12%)
Query: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK 403
++K R+R++ P + +E+++ R R++ ++ RE+ K R +E++REKER R++
Sbjct: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERER---KRRREEEEREKERARDR 287
Query: 404 EREKE-KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462
ER K + R ++ R +R R +D ++ R RER + +DR + + ++ + K R +
Sbjct: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS 347
Query: 463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522
R R RS SR+R+ + RS SR + K K R
Sbjct: 348 RD------------------------RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383
Query: 523 PSPRSRNKKDKKREKE-RDHISERRERERSTSMRKSSNDRDGKEKLEKN 570
+ + K REK+ D +E +E + + +S D + + N
Sbjct: 384 SDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
Score = 67.4 bits (163), Expect = 4e-11
Identities = 53/160 (33%), Positives = 76/160 (47%), Gaps = 19/160 (11%)
Query: 277 EVMKRVREAQSFISAAIEPESGKSNERKGGRSR----SHTRSKSRSSSKSHSRRKRSQSK 332
E KR R S + +S + K RSR S +R + R S+SH RS+ K
Sbjct: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRR--SRSHD---RSERK 342
Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392
HRSRS +R RS+ +DR+ +K RSKSR+R + R + K K+ R +K VK
Sbjct: 343 HRSRSRDRRRSKSRDRK----SYKHRSKSRDREQDR-----KSKEKEKRGSDDKKSSVKS 393
Query: 393 KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD 432
REK+ E KE + KN+ + E D + +
Sbjct: 394 GSREKQSEDTNTESKESDT-KNEVNGTSEDIKSEGDTQSN 432
>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens]
Length = 1341
Score = 111 bits (278), Expect = 2e-24
Identities = 77/277 (27%), Positives = 139/277 (50%), Gaps = 25/277 (9%)
Query: 223 RFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKP-------PEMTPQAAAKEL 275
+F ++A+Q+ L ++ + DRP + I +P P PQ E
Sbjct: 1080 KFLCADYAEQDE----LDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQ 1135
Query: 276 EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS 335
E + VRE + +E +ER+ R + +SRS S+ R++R++SK +
Sbjct: 1136 REQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEK- 1194
Query: 336 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 395
+S +K++ + + P K + K+ + D++ KE ER +
Sbjct: 1195 ------KSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLT-DSQIVQKEAERAERAKE 1247
Query: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR---DKEKEKE 452
++R +E+E E++KER K +R++ R+ +REK +E RER+RE+E E++R D+++++E
Sbjct: 1248 REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRE 1307
Query: 453 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
+D+E+ RE+DR D KR +SR+ P RR
Sbjct: 1308 RDRERGRERDRR---DTKRHSRSRSRSTPVRDRGGRR 1341
Score = 98.6 bits (244), Expect = 2e-20
Identities = 54/214 (25%), Positives = 118/214 (55%), Gaps = 25/214 (11%)
Query: 311 HTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSR 370
H R++ R ++ + + + R R+ DR + + + RS+SR+RR+ + R
Sbjct: 1130 HPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR-KER 1188
Query: 371 SHSRDKRKDTREKIKEKERVKEKDR----------------------EKEREREKEREKE 408
+ S++K+ + +EK +E+ K D +KE ER + ++
Sbjct: 1189 AKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKER 1248
Query: 409 KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKER-EKDRSKEI 467
++R K ++ ++++E+++E ++E++R+ EREK E R++++E+E+++E++R ++DR +E
Sbjct: 1249 EKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRER 1308
Query: 468 DEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501
D +R +++ R R ++ SR + R+R RR
Sbjct: 1309 DRERGRERDRRDTKR-HSRSRSRSTPVRDRGGRR 1341
Score = 96.7 bits (239), Expect = 6e-20
Identities = 106/453 (23%), Positives = 182/453 (40%), Gaps = 85/453 (18%)
Query: 103 EESKALSLLAPAPTMTSLMPGAGLLPIPTPNPL--TTLGV-----SLSSLGAIPAAALDP 155
EE K P P S+ LP P + + TLG S+S + + +D
Sbjct: 939 EEEKEPEAEPPVPPQVSVEVA---LPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDD 995
Query: 156 NIATLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMA 215
+ T ++P PP +I V++ NL + T QL E + G +
Sbjct: 996 PVRT-AQVPSPPR---------GKISNIVHISNL-VRPFTLGQLKELLGRTGTLVEEAFW 1044
Query: 216 GDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKEL 275
D+ + FV ++ +V A+A + G VK P+ P+ +
Sbjct: 1045 IDKIKS--HCFVTYS---TVEEAVATRTALHG-------------VKWPQSNPKFLCADY 1086
Query: 276 EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS 335
E E ++ S E +G H H R ++ + +
Sbjct: 1087 AEQ----DELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAV 1142
Query: 336 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 395
R R R+ +RR ++ + + R RSRS SRD+R+ R K KEK K + +
Sbjct: 1143 REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEK---KSEKK 1199
Query: 396 EKEREREKER--------------------------EKEKERGKNKDRDKEREKDREKDK 429
EK +E + +KE ER + ++R K++E+++
Sbjct: 1200 EKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEE 1259
Query: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE-KRKKDKKSRTPPRSYNASR 488
+K+RE+E E+E + ++EK +E +E++RE++R +E D R +D++
Sbjct: 1260 QKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRE------------ 1307
Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSR 521
R R RER RR ++ SRS S ++ + R
Sbjct: 1308 RDRERGRERDRRDTKRHSRSRSRSTPVRDRGGR 1340
Score = 83.6 bits (205), Expect = 5e-16
Identities = 68/228 (29%), Positives = 107/228 (46%), Gaps = 36/228 (15%)
Query: 381 REKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE 440
R + +E+ER +++ ERERE ER + + DRDK RE R + + +DR R KE
Sbjct: 1132 RAEQREQERAV-REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR---KE 1187
Query: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY------------NASR 488
K ++K+ EK KEK +E+ +K +D+ +K K + P Y A R
Sbjct: 1188 RAKSKEKKSEK---KEKAQEEPPAKLLDDLFRKTKAA---PCIYWLPLTDSQIVQKEAER 1241
Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER-RE 547
R+ RE+RR+ + R + + R RN++ +REK R+H ER RE
Sbjct: 1242 AERAKEREKRRKEQEEEEQKEREKE----------AERERNRQ-LEREKRREHSRERDRE 1290
Query: 548 RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKD 595
RER + DRD + E+ +++ K S S+ +D
Sbjct: 1291 RERERERDRGDRDRDRERDRERGRE--RDRRDTKRHSRSRSRSTPVRD 1336
Score = 81.6 bits (200), Expect = 2e-15
Identities = 66/219 (30%), Positives = 109/219 (49%), Gaps = 34/219 (15%)
Query: 370 RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKERE-KDREKD 428
R+ R++ + RE+ E+ER E+ ERE +R+K +E +++ R ++R K+R K
Sbjct: 1132 RAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKS 1191
Query: 429 KEKDREREREKEHEK-----DRDKEKEK------------EQDKEKEREK-DRSKEIDEK 470
KEK E++ + + E D K K Q +KE E+ +R+KE +++
Sbjct: 1192 KEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKR 1251
Query: 471 RKKDKKSRTPPRSYNASR-RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRN 529
RK+ ++ R A R R+R RE+RR SR R +R+ R R R+
Sbjct: 1252 RKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRER------ERERERDRGDRDRD 1305
Query: 530 K-KDKKREKERDHISERRE---RERSTSMRKSSNDRDGK 564
+ +D++R +ERD +R R RST +R DR G+
Sbjct: 1306 RERDRERGRERDRRDTKRHSRSRSRSTPVR----DRGGR 1340
Score = 58.2 bits (139), Expect = 2e-08
Identities = 85/405 (20%), Positives = 153/405 (37%), Gaps = 36/405 (8%)
Query: 162 EIPQPPLMGNVDPS---KIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDE 218
++P+ P DPS K+ E+ G Q L +Q G K + +
Sbjct: 41 KLPKMPEAVGTDPSTSRKMAELEEVTLDGK-PLQALRVTDLKAALEQRGLAKSGQKSALV 99
Query: 219 TQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEV 278
+ +E ++S P A G+ + + + K E+ Q +E E
Sbjct: 100 KRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREA 159
Query: 279 MKRVREAQSF----------ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 328
+ + EA + +++ + P+ S ER H S +SSS S +
Sbjct: 160 AE-LEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH--SPRKSSSISEEKGDS 216
Query: 329 SQSKHRSRSHNRSRSRQ-KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEK 387
K R SR RQ + + S+ + + SR+ D+ T E+ +E+
Sbjct: 217 DDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEE 276
Query: 388 ERVKEKDREKEREREKEREKE-------KERGKNKDRDKEREKDREKDKEKDREREREKE 440
E +E D E+E + E ++ +E KE G+ R K E E+ K R +E+E
Sbjct: 277 EEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKT--RSQEQEVL 334
Query: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS----RE 496
R ++E K + + KE+ +++ R S +S+S S E
Sbjct: 335 ERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTE 394
Query: 497 RRRRRS-----RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536
R++ S ++ T + K + SP P + +++ E
Sbjct: 395 DRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIE 439
Score = 55.5 bits (132), Expect = 1e-07
Identities = 57/294 (19%), Positives = 117/294 (39%), Gaps = 10/294 (3%)
Query: 267 TPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS-SKSHSR 325
TP AA + ++ + + + SFI +E + +R +R + S+ S+
Sbjct: 116 TPHAAFQPNSQIGEEMSQ-NSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMI 174
Query: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK 385
+ S R + SP K S S E+ S + +R+ +R +
Sbjct: 175 HPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQA 234
Query: 386 EKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR 445
++ E + E E ++E R + DR+ + E++ E E E E+E +++
Sbjct: 235 RAAKLSEGSQPAEEEEDQETPSRNLRVR-ADRNLKTEEEEE-------EEEEEEEDDEEE 286
Query: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 505
+ + E ++ +E K+ +E +E + + R S+ R R RS+
Sbjct: 287 EGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEE 346
Query: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 559
+R ++ + K ++ SP +++ K + S+ R T RK ++
Sbjct: 347 ARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKAS 400
Score = 55.5 bits (132), Expect = 1e-07
Identities = 75/327 (22%), Positives = 118/327 (36%), Gaps = 44/327 (13%)
Query: 300 SNERKGGRSRSHT--------------RSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSR 344
S E+K GR SHT S+S SSS S SR R RS SRSH+ RS+
Sbjct: 551 SLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSK 610
Query: 345 QKD----------RRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKD 394
Q+D R R K + S+SR R +SRSRS S + RK + ++
Sbjct: 611 QRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVS-----RDSS 665
Query: 395 REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQD 454
++ +E K+R + R + E EK Q
Sbjct: 666 TSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPE---SAEKHVTQR 722
Query: 455 KEKEREKDRSKEIDEKR----KKDKKSRTPPRSYNASRRSRSSSRERRR-----RRSRSS 505
+ ER + E +E + + S T S R + E+ +R
Sbjct: 723 LQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPE 782
Query: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS--MRKSSNDRDG 563
+ P I + S P + ++K+E +R+ S + + ++D +G
Sbjct: 783 NDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEG 842
Query: 564 KEKLEKNSTSLKEKEHNKEPDSSVSKE 590
+ K K+P S++ E
Sbjct: 843 GQPGRKRRWGASTATTQKKPSISITTE 869
Score = 48.9 bits (115), Expect = 1e-05
Identities = 46/234 (19%), Positives = 97/234 (41%), Gaps = 28/234 (11%)
Query: 371 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKE 430
S R + + +R ++ + E+ + + E+ ++ E+ R + K E + ++E
Sbjct: 190 SLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEE 249
Query: 431 KDRER-EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
+D+E R DR+ + E+E+++E+E E+D +E E + +KSR P
Sbjct: 250 EDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEE--EGDDEGQKSREAPILKEFKEE 307
Query: 490 SRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERE 549
R +K + P++R+++ + E+ + E
Sbjct: 308 GEEIPR-------------------VKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEA- 347
Query: 550 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603
RKS R +EK K ++ L+E+E + + ++ PR E++
Sbjct: 348 -----RKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDR 396
Score = 48.5 bits (114), Expect = 2e-05
Identities = 65/341 (19%), Positives = 123/341 (36%), Gaps = 38/341 (11%)
Query: 282 VREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ-----SKHRSR 336
+R Q ++ A + + + G RS S +RS+SRS S+S S R S+ S
Sbjct: 607 LRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSST 666
Query: 337 SHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDRE 396
S+ ++ + + P + + ++ + S S R+ ++ + EK + E
Sbjct: 667 SYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPE 726
Query: 397 KEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQD-- 454
+ ++ E E+ + + + E + + E+ EKE E E D
Sbjct: 727 RGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVP 786
Query: 455 -------------------KEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495
E E +K+ S KRK S T S
Sbjct: 787 EPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPG 846
Query: 496 ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMR 555
+RR + +++ + S +I +S +S P + ++ + H + R E T
Sbjct: 847 RKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDL-HADDSRISEDETERN 905
Query: 556 KSSNDRDGKEKLEKNSTSL-----------KEKEHNKEPDS 585
D K+ + T + +E+E KEP++
Sbjct: 906 GDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEA 946
Score = 40.8 bits (94), Expect = 0.004
Identities = 79/386 (20%), Positives = 137/386 (35%), Gaps = 56/386 (14%)
Query: 261 VKPPEMT---PQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317
VKP EM P+ ++E +EV++R A + + + K ++ S + R
Sbjct: 314 VKPEEMMDERPKTRSQE-QEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEER 372
Query: 318 SSSKSHSRRKRSQSKHRSR-SHNRSRSR-----QKDRRRSKSPHKKRSKSRERRKSRSRS 371
S +++S+S R + +R ++ ++ ++P +K +
Sbjct: 373 EIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQL 432
Query: 372 HSRDKRK--------------------DTREKIKEKERVK------EKDREKEREREKER 405
HS ++ + DTRE + + V+ + + E
Sbjct: 433 HSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPA 492
Query: 406 EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 465
EK E K D K+ + E +R + + +E + +E K S
Sbjct: 493 EKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSL 552
Query: 466 EIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP 525
E E R+ R ++ S S S SRS SRSP +S SRS SP
Sbjct: 553 EQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSS------GSRSHSP 606
Query: 526 RSRNKKDKKREKERDH-----------ISERRERERSTSMRKSSNDRDGKEKLEKNSTSL 574
++D + + + SE R R RS S SSN R + L +
Sbjct: 607 LRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSR---KSLSPGVSRD 663
Query: 575 KEKEHNKEPDSSVSKEVDDKDAPRTE 600
+ + D S +EV P+ +
Sbjct: 664 SSTSYTETKDPSSGQEVATPPVPQLQ 689
Score = 37.4 bits (85), Expect = 0.042
Identities = 51/245 (20%), Positives = 92/245 (37%), Gaps = 28/245 (11%)
Query: 386 EKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR 445
+K+ E DR + K E +G ++ K+ ++++ + ++
Sbjct: 515 QKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSA 574
Query: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYN---ASRRSRSSSRERRRRRS 502
D + + RS+ D +S +P RS A R+ ++ R R + S
Sbjct: 575 DSSSSRSSSSSSSSSRSRSRSPDSS---GSRSHSPLRSKQRDVAQARTHANPRGRPKMGS 631
Query: 503 RSSSRS-------PRTSKTIKRKS-----SRSPSPRSRNKKDKKREKE-------RDHIS 543
RS+S S R++ + RKS SR S KD +E + +
Sbjct: 632 RSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVC 691
Query: 544 ERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA--PRTEE 601
E +ER ++S + E EK+ T + E P ++E + A P+T E
Sbjct: 692 EPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERG-SPKKCEAEEAEPPAATQPQTSE 750
Query: 602 NKIQH 606
+ H
Sbjct: 751 TQTSH 755
Score = 37.0 bits (84), Expect = 0.054
Identities = 39/199 (19%), Positives = 78/199 (39%), Gaps = 19/199 (9%)
Query: 426 EKDKEKDRER-EREKEHEKDRDKEKEKEQDKEKEREKDRS------------KEIDEKRK 472
EK +E R+R ERE + ++ + +D+ E S E++ R
Sbjct: 142 EKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH 201
Query: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRR---SRSSSRSPRTSKTIKRKSSRSPSPRSRN 529
+KS + S + ERR R +R++ S + + + +PS R
Sbjct: 202 SPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRV 261
Query: 530 KKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK 589
+ D+ + E + E E E + D +G++ E ++E + P +
Sbjct: 262 RADRNLKTEEE---EEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEE 318
Query: 590 EVDDKDAPRTEENKIQHNG 608
+D++ R++E ++ G
Sbjct: 319 MMDERPKTRSQEQEVLERG 337
Score = 31.2 bits (69), Expect = 3.0
Identities = 24/117 (20%), Positives = 48/117 (41%), Gaps = 1/117 (0%)
Query: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 505
D ++ E D + DR E + + + PP + +R + R+
Sbjct: 1085 DYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVRE 1144
Query: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRD 562
+ R + +R+ +RS R+K ++ + R +RR +ER+ S K S ++
Sbjct: 1145 QWAEREREMERRERTRSEREWDRDKV-REGPRSRSRSRDRRRKERAKSKEKKSEKKE 1200
Score = 30.4 bits (67), Expect = 5.1
Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 12/83 (14%)
Query: 523 PSPRSRNKKDKKREK--ERDHISERRERERS----------TSMRKSSNDRDGKEKLEKN 570
P R ++ RE+ ER+ ERRER RS R S RD + K
Sbjct: 1131 PRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAK 1190
Query: 571 STSLKEKEHNKEPDSSVSKEVDD 593
S K ++ K + +K +DD
Sbjct: 1191 SKEKKSEKKEKAQEEPPAKLLDD 1213
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 110 bits (276), Expect = 3e-24
Identities = 92/331 (27%), Positives = 158/331 (47%), Gaps = 33/331 (9%)
Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 353
+ K + + G R H R + + + R + + + Q+ R+ K
Sbjct: 5 DDRDSKRDSLEEGELRDH-RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV 63
Query: 354 PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK 413
H+K K +E+R R RSHS + K R +KEKER E+ R++ RE + + +E ER K
Sbjct: 64 HHRKDEKRKEKR--RHRSHSAEGGKHAR--VKEKEREHER-RKRHREEQDKARREWERQK 118
Query: 414 NKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE-KDRSKEIDEKRK 472
++ +E + RE+D+ + ER+RE+E K R+++KE+ + KE+ER ++R KE + +R+
Sbjct: 119 RREMAREHSR-RERDRLEQLERKRERE-RKMREQQKEQREQKERERRAEERRKEREARRE 176
Query: 473 KDKKSRTPPRSYN----ASRRSRSSSRERRRRRSRSSSRSPRTSKTI------------- 515
RT Y+ AS SRS R R R R P + +
Sbjct: 177 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS 236
Query: 516 --KRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTS 573
+RK+S + S + + + E+E + E E E STS + S + + +E+ E+ T
Sbjct: 237 DSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTS--EESEEEEEEEEEEEEETG 291
Query: 574 LKEKEHNKEPDSSVSKEVDDKDAPRTEENKI 604
+E +++ VS+E +D R EN +
Sbjct: 292 SNSEEASEQSAEEVSEEEMSEDEERENENHL 322
Score = 101 bits (251), Expect = 2e-21
Identities = 86/315 (27%), Positives = 153/315 (48%), Gaps = 47/315 (14%)
Query: 345 QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK---------IKEKERVKEKDR 395
Q D R SK + + R+ R + +S +R+D+ E IK +++ K++
Sbjct: 3 QSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK 62
Query: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDK-EKEKEQD 454
R+ EK +EK + R + + K + KEK+RE ER K H +++DK +E E+
Sbjct: 63 VHHRKDEKRKEKRRHRSHSAEGGK-----HARVKEKEREHERRKRHREEQDKARREWERQ 117
Query: 455 KEKE-------REKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERR-----RRRS 502
K +E RE+DR ++++ KR++++K R + + + ERR RR
Sbjct: 118 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 177
Query: 503 RSSSRSPRTSKTIKRKS---SRSP--SPRSR-----NKKDKKREK--ERDHISERR---E 547
+ R+ R + K K+ SRSP PR R +K K EK ERD +S+ + +
Sbjct: 178 SAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISD 237
Query: 548 RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHN 607
ER TS +SS+ G E+ +E+E +E + S S+E ++++ EE + +
Sbjct: 238 SERKTSSAESSSAESGSGSEEE-----EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGS 292
Query: 608 GNCQLNEENLSTKTE 622
+ + +E++ +E
Sbjct: 293 NSEEASEQSAEEVSE 307
Score = 72.4 bits (176), Expect = 1e-12
Identities = 65/305 (21%), Positives = 120/305 (39%), Gaps = 85/305 (27%)
Query: 261 VKPPEMTPQAAAKEL-----EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHT--- 312
+KPP+ Q + KE +E K R +S + + K ER+ R + H
Sbjct: 51 IKPPQ---QMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQ 107
Query: 313 --------RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER 364
R K R ++ HSRR+R + + R R R ++ ++ + ++ ++ ER
Sbjct: 108 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 167
Query: 365 RKSRSR-----SHSRDKRKDTREKIK-------------------------EKERVKEKD 394
RK R +H R R+D +K+K ++E+++E+D
Sbjct: 168 RKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD 227
Query: 395 --------------------------REKEREREKEREKEKERGKNKDRDKEREKDREKD 428
E E E+E E+E+E +++ ++E E++ E++
Sbjct: 228 LLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEE 287
Query: 429 KEKDREREREKEHEKDRDKEKEKEQDKEKEREK----------DRSKEIDEKRKKDKKSR 478
+E E E + E+E +D+E+E E DR E+ +++
Sbjct: 288 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG 347
Query: 479 TPPRS 483
TP S
Sbjct: 348 TPQSS 352
Score = 62.8 bits (151), Expect = 9e-10
Identities = 62/237 (26%), Positives = 109/237 (45%), Gaps = 21/237 (8%)
Query: 369 SRSHSRDKRKDTREKIKEKE-RVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREK 427
S+S RD ++D+ E+ + ++ R++ R RE E +RG+ D + +
Sbjct: 2 SQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSME---DRGEEDDSLAIKPPQQMS 58
Query: 428 DKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNAS 487
KEK R+ EK EK R + E K R K++ +E E+RK+ ++ + R
Sbjct: 59 RKEKVHHRKDEKRKEKRRHRSHSAEGGKHA-RVKEKERE-HERRKRHREEQDKARREWER 116
Query: 488 RRSRSSSRER-RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR 546
++ R +RE RR R R + ++RK R R + +K+++ +KER+ +E R
Sbjct: 117 QKRREMAREHSRRERDR--------LEQLERKRERERKMREQ-QKEQREQKERERRAEER 167
Query: 547 ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK--EVDDKDAPRTEE 601
+ER S++ R +E S +K ++ P + E+ D P EE
Sbjct: 168 RKEREARREVSAHHRTMREDY---SDKVKASHWSRSPPRPPRERFELGDGRKPVKEE 221
Score = 43.5 bits (101), Expect = 6e-04
Identities = 47/217 (21%), Positives = 83/217 (38%), Gaps = 47/217 (21%)
Query: 426 EKDKEKDRERERE-KEHEKD---RDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP 481
++D ++D E E ++H + R+ +E E E+D S I ++ +K +
Sbjct: 6 DRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV-- 63
Query: 482 RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDH 541
R +E+RR RS S+ K + +EKER+H
Sbjct: 64 -----HHRKDEKRKEKRRHRSHSAEGG---------------------KHARVKEKEREH 97
Query: 542 ISERRERERSTSMRK--------------SSNDRDGKEKLE-KNSTSLKEKEHNKEPDSS 586
+R RE R+ S +RD E+LE K K +E KE
Sbjct: 98 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 157
Query: 587 VSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTEA 623
+E ++ + E + + + + + E+ S K +A
Sbjct: 158 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKA 194
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 110 bits (276), Expect = 3e-24
Identities = 92/331 (27%), Positives = 158/331 (47%), Gaps = 33/331 (9%)
Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 353
+ K + + G R H R + + + R + + + Q+ R+ K
Sbjct: 39 DDRDSKRDSLEEGELRDH-RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV 97
Query: 354 PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK 413
H+K K +E+R R RSHS + K R +KEKER E+ R++ RE + + +E ER K
Sbjct: 98 HHRKDEKRKEKR--RHRSHSAEGGKHAR--VKEKEREHER-RKRHREEQDKARREWERQK 152
Query: 414 NKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE-KDRSKEIDEKRK 472
++ +E + RE+D+ + ER+RE+E K R+++KE+ + KE+ER ++R KE + +R+
Sbjct: 153 RREMAREHSR-RERDRLEQLERKRERE-RKMREQQKEQREQKERERRAEERRKEREARRE 210
Query: 473 KDKKSRTPPRSYN----ASRRSRSSSRERRRRRSRSSSRSPRTSKTI------------- 515
RT Y+ AS SRS R R R R P + +
Sbjct: 211 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS 270
Query: 516 --KRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTS 573
+RK+S + S + + + E+E + E E E STS + S + + +E+ E+ T
Sbjct: 271 DSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTS--EESEEEEEEEEEEEEETG 325
Query: 574 LKEKEHNKEPDSSVSKEVDDKDAPRTEENKI 604
+E +++ VS+E +D R EN +
Sbjct: 326 SNSEEASEQSAEEVSEEEMSEDEERENENHL 356
Score = 103 bits (256), Expect = 6e-22
Identities = 87/334 (26%), Positives = 160/334 (47%), Gaps = 47/334 (14%)
Query: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK-- 383
+++ + K + R + D R SK + + R+ R + +S +R+D+ E
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRG 77
Query: 384 -------IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436
IK +++ K++ R+ EK +EK + R + + K + KEK+RE E
Sbjct: 78 EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK-----HARVKEKEREHE 132
Query: 437 REKEHEKDRDK-EKEKEQDKEKE-------REKDRSKEIDEKRKKDKKSRTPPRSYNASR 488
R K H +++DK +E E+ K +E RE+DR ++++ KR++++K R + +
Sbjct: 133 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK 192
Query: 489 RSRSSSRERR-----RRRSRSSSRSPRTSKTIKRKS---SRSP--SPRSR-----NKKDK 533
+ ERR RR + R+ R + K K+ SRSP PR R +K
Sbjct: 193 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 252
Query: 534 KREK--ERDHISERR---ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVS 588
K EK ERD +S+ + + ER TS +SS+ G E+ +E+E +E + S S
Sbjct: 253 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE-----EEEEEEEEEEGSTS 307
Query: 589 KEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTE 622
+E ++++ EE + + + + +E++ +E
Sbjct: 308 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSE 341
Score = 72.4 bits (176), Expect = 1e-12
Identities = 65/305 (21%), Positives = 120/305 (39%), Gaps = 85/305 (27%)
Query: 261 VKPPEMTPQAAAKEL-----EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHT--- 312
+KPP+ Q + KE +E K R +S + + K ER+ R + H
Sbjct: 85 IKPPQ---QMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQ 141
Query: 313 --------RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER 364
R K R ++ HSRR+R + + R R R ++ ++ + ++ ++ ER
Sbjct: 142 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 201
Query: 365 RKSRSR-----SHSRDKRKDTREKIK-------------------------EKERVKEKD 394
RK R +H R R+D +K+K ++E+++E+D
Sbjct: 202 RKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD 261
Query: 395 --------------------------REKEREREKEREKEKERGKNKDRDKEREKDREKD 428
E E E+E E+E+E +++ ++E E++ E++
Sbjct: 262 LLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEE 321
Query: 429 KEKDREREREKEHEKDRDKEKEKEQDKEKEREK----------DRSKEIDEKRKKDKKSR 478
+E E E + E+E +D+E+E E DR E+ +++
Sbjct: 322 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG 381
Query: 479 TPPRS 483
TP S
Sbjct: 382 TPQSS 386
Score = 58.5 bits (140), Expect = 2e-08
Identities = 59/257 (22%), Positives = 103/257 (40%), Gaps = 51/257 (19%)
Query: 385 KEKERVKEKD---REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEH 441
K+ +VK D +EK+R +E+E + E +R KN D ++D ++D ++ E +
Sbjct: 5 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSD-----DRDSKRDSLEEGELRDHRME 59
Query: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501
R+ +E E E+D S I ++ +K + R +E+RR R
Sbjct: 60 ITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV-------HHRKDEKRKEKRRHR 112
Query: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK----- 556
S S+ K + +EKER+H +R RE R+
Sbjct: 113 SHSAEGG---------------------KHARVKEKEREHERRKRHREEQDKARREWERQ 151
Query: 557 ---------SSNDRDGKEKLE-KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQH 606
S +RD E+LE K K +E KE +E ++ + E + +
Sbjct: 152 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 211
Query: 607 NGNCQLNEENLSTKTEA 623
+ + + E+ S K +A
Sbjct: 212 SAHHRTMREDYSDKVKA 228
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 107 bits (267), Expect = 3e-23
Identities = 86/308 (27%), Positives = 153/308 (49%), Gaps = 36/308 (11%)
Query: 331 SKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKS-----------RSRSHSRDKRKD 379
SK S R + + SP+++ +R + SR RKD
Sbjct: 9 SKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 68
Query: 380 TREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD-RERERE 438
+ K K+ RVKEK+RE ER + E++K R R+ ER+K RE +E RER+R
Sbjct: 69 EKRKEKKHARVKEKEREHERRKRHREEQDKAR-----REWERQKRREMAREHSRRERDRL 123
Query: 439 KEHEKDRDKE-KEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER 497
++ E+ R++E K +EQ KE+ +K+R + +E R+K++++R +++ + R S + +
Sbjct: 124 EQLERKRERERKMREQQKEQREQKERERRAEE-RRKEREARREVSAHHRTMREDYSDKVK 182
Query: 498 RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR---ERERSTSM 554
SRS R PR + + R P K++K E ERD +S+ + + ER TS
Sbjct: 183 ASHWSRSPPRPPR--ERFELGDGRKP------VKEEKME-ERDLLSDLQDISDSERKTSS 233
Query: 555 RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNE 614
+SS+ G E+ +E+E +E + S S+E ++++ EE + + + + +E
Sbjct: 234 AESSSAESGSGSEEE-----EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE 288
Query: 615 ENLSTKTE 622
++ +E
Sbjct: 289 QSAEEVSE 296
Score = 103 bits (257), Expect = 5e-22
Identities = 86/318 (27%), Positives = 147/318 (46%), Gaps = 29/318 (9%)
Query: 308 SRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKS 367
S+S R R S + R S R +DR + + RK
Sbjct: 2 SQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKE 61
Query: 368 RSRSHSRDKRKDTRE-KIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDRE 426
+ +KRK+ + ++KEKER E+ R++ RE + + +E ER K ++ +E + RE
Sbjct: 62 KVHHRKDEKRKEKKHARVKEKEREHER-RKRHREEQDKARREWERQKRREMAREHSR-RE 119
Query: 427 KDKEKDREREREKEHEKDRDKEKEKEQDKEKERE-KDRSKEIDEKRKKDKKSRTPPRSYN 485
+D+ + ER+RE+E K R+++KE+ + KE+ER ++R KE + +R+ RT Y+
Sbjct: 120 RDRLEQLERKRERE-RKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS 178
Query: 486 ----ASRRSRSSSRERRRRRSRSSSRSPRTSKTI---------------KRKSSRSPSPR 526
AS SRS R R R R P + + +RK+S + S
Sbjct: 179 DKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSS 238
Query: 527 SRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSS 586
+ + + E+E + E E E STS + S + + +E+ E+ T +E +++
Sbjct: 239 AESGSGSEEEEEEE---EEEEEEGSTS--EESEEEEEEEEEEEEETGSNSEEASEQSAEE 293
Query: 587 VSKEVDDKDAPRTEENKI 604
VS+E +D R EN +
Sbjct: 294 VSEEEMSEDEERENENHL 311
Score = 71.2 bits (173), Expect = 3e-12
Identities = 62/297 (20%), Positives = 118/297 (39%), Gaps = 80/297 (26%)
Query: 261 VKPPEMTPQAAA-------KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSH-T 312
+KPP+ + K E+ RV+E + E E K + + ++R
Sbjct: 51 IKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKER------EHERRKRHREEQDKARREWE 104
Query: 313 RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSR-- 370
R K R ++ HSRR+R + + R R R ++ ++ + ++ ++ ERRK R
Sbjct: 105 RQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARR 164
Query: 371 ---SHSRDKRKDTREKIK-------------------------EKERVKEKD-------- 394
+H R R+D +K+K ++E+++E+D
Sbjct: 165 EVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDI 224
Query: 395 ------------------REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436
E E E+E E+E+E +++ ++E E++ E+++E E
Sbjct: 225 SDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSE 284
Query: 437 REKEHEKDRDKEKEKEQDKEKEREK----------DRSKEIDEKRKKDKKSRTPPRS 483
E + E+E +D+E+E E DR E+ +++ TP S
Sbjct: 285 EASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSS 341
Score = 43.1 bits (100), Expect = 8e-04
Identities = 39/186 (20%), Positives = 74/186 (39%), Gaps = 20/186 (10%)
Query: 453 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTS 512
Q +++ ++D ++E +D + R N+ R S +R + + P+
Sbjct: 3 QSDDRDSKRD---SLEEGELRDHRMEITIR--NSPYRREDSMEDRGEEDDSLAIKPPQQM 57
Query: 513 KTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK--------------SS 558
++ R R K + +EKER+H +R RE R+ S
Sbjct: 58 SRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSR 117
Query: 559 NDRDGKEKLE-KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENL 617
+RD E+LE K K +E KE +E ++ + E + + + + + E+
Sbjct: 118 RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDY 177
Query: 618 STKTEA 623
S K +A
Sbjct: 178 SDKVKA 183
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,010,981
Number of Sequences: 37866
Number of extensions: 1379166
Number of successful extensions: 108939
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1607
Number of HSP's successfully gapped in prelim test: 1191
Number of HSP's that attempted gapping in prelim test: 14961
Number of HSP's gapped (non-prelim): 27195
length of query: 624
length of database: 18,247,518
effective HSP length: 108
effective length of query: 516
effective length of database: 14,157,990
effective search space: 7305522840
effective search space used: 7305522840
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.