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Search of human proteins with 23110989
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23110989 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
(297 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23110987 membrane-spanning 4-domains, subfamily A, member 1 [... 592 e-169
gi|23110989 membrane-spanning 4-domains, subfamily A, member 1 [... 592 e-169
gi|149588599 membrane-spanning 4-domains, subfamily A, member 15... 79 6e-15
gi|20070328 membrane-spanning 4-domains, subfamily A, member 4 i... 78 1e-14
gi|23110995 membrane-spanning 4-domains, subfamily A, member 4 i... 78 1e-14
gi|8923206 membrane-spanning 4-domains, subfamily A, member 12 [... 75 5e-14
gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B ... 71 1e-12
gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A... 64 2e-10
gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A... 64 2e-10
gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A... 64 2e-10
gi|23110997 membrane-spanning 4-domains, subfamily A, member 5 [... 61 1e-09
gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A ... 57 3e-08
gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A ... 56 4e-08
gi|169202868 PREDICTED: similar to membrane-spanning 4-domains, ... 54 2e-07
gi|169203526 PREDICTED: similar to membrane-spanning 4-domains, ... 54 2e-07
gi|169202217 PREDICTED: similar to membrane-spanning 4-domains, ... 54 2e-07
gi|22749421 membrane-spanning 4-domains, subfamily A, member 15 ... 54 2e-07
gi|167466260 membrane-spanning 4-domains, subfamily A, member 10... 53 3e-07
gi|119226217 membrane-spanning 4-domains, subfamily A, member 14... 50 3e-06
gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A ... 50 3e-06
gi|4503677 membrane-spanning 4-domains, subfamily A, member 2 is... 45 1e-04
gi|214831008 membrane-spanning 4-domains, subfamily A, member 2 ... 44 2e-04
gi|11139299 membrane-spanning 4-domains, subfamily A, member 7 i... 42 5e-04
gi|46249357 membrane-spanning 4-domains, subfamily A, member 7 i... 42 5e-04
gi|73486649 membrane-spanning 4-domains, subfamily A, member 3 i... 42 8e-04
gi|155029533 membrane-spanning 4-domains, subfamily A, member 13... 40 0.003
gi|21361639 DIPB protein [Homo sapiens] 37 0.027
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 36 0.036
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 35 0.10
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 34 0.14
>gi|23110987 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 592 bits (1526), Expect = e-169
Identities = 297/297 (100%), Positives = 297/297 (100%)
Query: 1 MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG 60
MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG
Sbjct: 1 MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG 60
Query: 61 LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN 120
LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN
Sbjct: 61 LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN 120
Query: 121 SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST 180
SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST
Sbjct: 121 SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST 180
Query: 181 QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI 240
QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI
Sbjct: 181 QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI 240
Query: 241 EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP 297
EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
Sbjct: 241 EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP 297
>gi|23110989 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 592 bits (1526), Expect = e-169
Identities = 297/297 (100%), Positives = 297/297 (100%)
Query: 1 MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG 60
MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG
Sbjct: 1 MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG 60
Query: 61 LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN 120
LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN
Sbjct: 61 LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN 120
Query: 121 SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST 180
SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST
Sbjct: 121 SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST 180
Query: 181 QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI 240
QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI
Sbjct: 181 QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI 240
Query: 241 EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP 297
EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
Sbjct: 241 EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP 297
>gi|149588599 membrane-spanning 4-domains, subfamily A, member 15
isoform 1 [Homo sapiens]
Length = 240
Score = 78.6 bits (192), Expect = 6e-15
Identities = 42/99 (42%), Positives = 55/99 (55%), Gaps = 1/99 (1%)
Query: 40 PTQSFFMRESKTLGAVQIMNGLFHIALGG-LLMIPAGIYAPICVTVWYPLWGGIMYIISG 98
P ++F E K LG VQI+ GL H+ G LLM+ G + P WGG +IISG
Sbjct: 62 PVETFLTGEPKVLGTVQILIGLIHLGFGSVLLMVRRGHVGIFFIEGGVPFWGGACFIISG 121
Query: 99 SLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMD 137
SL A EKN CLV+ + N LS+ AA +G + +MD
Sbjct: 122 SLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMD 160
>gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
isoform a [Homo sapiens]
Length = 220
Score = 77.8 bits (190), Expect = 1e-14
Identities = 62/236 (26%), Positives = 100/236 (42%), Gaps = 30/236 (12%)
Query: 7 SVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIAL 66
++ G A P GP Q G + G + F E K LG VQI+ L +++
Sbjct: 3 TMQGMEQAMPGAGPGVPQLGNMAVIHS-HLWKGLQEKFLKGEPKVLGVVQILTALMSLSM 61
Query: 67 GGLLMIPAG-IYA--PICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLS 123
G +M A Y PI V + Y +WG +M+IISGSL A + K LV+G + MN S
Sbjct: 62 GITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITS 121
Query: 124 LFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYC 183
A SG++++ SL F H PY N Y ++ C
Sbjct: 122 SVLAASGILINTF--------------SLAFYSFHHPYCNYYG------------NSNNC 155
Query: 184 YSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQT 239
+ S+ +G+ ++L+ + + + + K C P +++L + +T
Sbjct: 156 HGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAET 211
>gi|23110995 membrane-spanning 4-domains, subfamily A, member 4
isoform b [Homo sapiens]
Length = 239
Score = 77.8 bits (190), Expect = 1e-14
Identities = 62/236 (26%), Positives = 100/236 (42%), Gaps = 30/236 (12%)
Query: 7 SVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIAL 66
++ G A P GP Q G + G + F E K LG VQI+ L +++
Sbjct: 22 TMQGMEQAMPGAGPGVPQLGNMAVIHS-HLWKGLQEKFLKGEPKVLGVVQILTALMSLSM 80
Query: 67 GGLLMIPAG-IYA--PICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLS 123
G +M A Y PI V + Y +WG +M+IISGSL A + K LV+G + MN S
Sbjct: 81 GITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITS 140
Query: 124 LFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYC 183
A SG++++ SL F H PY N Y ++ C
Sbjct: 141 SVLAASGILINTF--------------SLAFYSFHHPYCNYYG------------NSNNC 174
Query: 184 YSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQT 239
+ S+ +G+ ++L+ + + + + K C P +++L + +T
Sbjct: 175 HGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAET 230
>gi|8923206 membrane-spanning 4-domains, subfamily A, member 12
[Homo sapiens]
Length = 267
Score = 75.5 bits (184), Expect = 5e-14
Identities = 43/107 (40%), Positives = 59/107 (55%), Gaps = 6/107 (5%)
Query: 38 VGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIY------APICVTVWYPLWGG 91
VG F E+K LG +QIM GL HI G +L + + + A V YP WGG
Sbjct: 77 VGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGG 136
Query: 92 IMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDI 138
+ +IISGSL + K +CLVKG + MN +S A G+IL ++D+
Sbjct: 137 LSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDM 183
>gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B
[Homo sapiens]
Length = 250
Score = 71.2 bits (173), Expect = 1e-12
Identities = 41/107 (38%), Positives = 61/107 (57%), Gaps = 2/107 (1%)
Query: 34 MSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLL-MIPAGIYAPICVTVWYPLWGGI 92
+S++ G ++E KTLGA+QI+ GL HI LG ++ + G Y I +P WGG+
Sbjct: 54 VSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGL 113
Query: 93 MYIISGSLLAATEKNSRK-CLVKGKMIMNSLSLFAAISGMILSIMDI 138
+IISGSL A E CL+ G + +N +S + G+IL I D+
Sbjct: 114 WFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDL 160
>gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 1 [Homo sapiens]
Length = 243
Score = 63.5 bits (153), Expect = 2e-10
Identities = 54/196 (27%), Positives = 87/196 (44%), Gaps = 30/196 (15%)
Query: 39 GPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPA-GIYA--PICVTVWYPLWGGIMYI 95
G + FF R+ K LG V+I+ L +++G ++M A Y PI V V Y +WG +M+I
Sbjct: 57 GLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFI 116
Query: 96 ISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFI 155
IS SL A + K LV G + N S AISG++++ + SL F
Sbjct: 117 ISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAI--------------SLTFY 162
Query: 156 RAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENE 215
Y N + + CY S+ +G ++L+ + + + +
Sbjct: 163 SFRYHYCN------------HDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVSLSAFG 210
Query: 216 WKRTCSRPKSNIVLLS 231
K C P S +VL++
Sbjct: 211 CKVLCCSP-SEVVLIT 225
>gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 63.5 bits (153), Expect = 2e-10
Identities = 54/196 (27%), Positives = 87/196 (44%), Gaps = 30/196 (15%)
Query: 39 GPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPA-GIYA--PICVTVWYPLWGGIMYI 95
G + FF R+ K LG V+I+ L +++G ++M A Y PI V V Y +WG +M+I
Sbjct: 57 GLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFI 116
Query: 96 ISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFI 155
IS SL A + K LV G + N S AISG++++ + SL F
Sbjct: 117 ISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAI--------------SLTFY 162
Query: 156 RAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENE 215
Y N + + CY S+ +G ++L+ + + + +
Sbjct: 163 SFRYHYCN------------HDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVSLSAFG 210
Query: 216 WKRTCSRPKSNIVLLS 231
K C P S +VL++
Sbjct: 211 CKVLCCSP-SEVVLIT 225
>gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 63.5 bits (153), Expect = 2e-10
Identities = 54/196 (27%), Positives = 87/196 (44%), Gaps = 30/196 (15%)
Query: 39 GPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPA-GIYA--PICVTVWYPLWGGIMYI 95
G + FF R+ K LG V+I+ L +++G ++M A Y PI V V Y +WG +M+I
Sbjct: 57 GLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFI 116
Query: 96 ISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFI 155
IS SL A + K LV G + N S AISG++++ + SL F
Sbjct: 117 ISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAI--------------SLTFY 162
Query: 156 RAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENE 215
Y N + + CY S+ +G ++L+ + + + +
Sbjct: 163 SFRYHYCN------------HDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFG 210
Query: 216 WKRTCSRPKSNIVLLS 231
K C P S +VL++
Sbjct: 211 CKVLCCSP-SEVVLIT 225
>gi|23110997 membrane-spanning 4-domains, subfamily A, member 5
[Homo sapiens]
Length = 200
Score = 60.8 bits (146), Expect = 1e-09
Identities = 48/173 (27%), Positives = 77/173 (44%), Gaps = 33/173 (19%)
Query: 36 SLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGL----LMIPAGIYAPICVTVWYPLWGG 91
S P Q F R+ K LG +QI+ G+ + G + L+ P + P YP WG
Sbjct: 34 STQSPLQKLFARKMKILGTIQILFGIMTFSFGVIFLFTLLKPYPRF-PFIFLSGYPFWGS 92
Query: 92 IMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMES 151
+++I SG+ L A ++ + + L+ IMN LS AI+G+IL +
Sbjct: 93 VLFINSGAFLIAVKRKTTETLIILSRIMNFLSALGAIAGIILLTFGFI----------LD 142
Query: 152 LNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQ 204
N+I + S +NS C ++ LFLGIL ++ F+ +
Sbjct: 143 QNYICGY--------------SHQNS----QCKAVTVLFLGILITLMTFSIIE 177
>gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A
isoform 1 [Homo sapiens]
Length = 248
Score = 56.6 bits (135), Expect = 3e-08
Identities = 51/192 (26%), Positives = 87/192 (45%), Gaps = 22/192 (11%)
Query: 48 ESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVW-------YPLWGGIMYIISGSL 100
E K +G +QI+ G+ ++LG +++ + ++P V YP G +IISGSL
Sbjct: 44 EIKVIGTIQILCGMMVLSLG--IILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSL 101
Query: 101 LAATEKNSRKCLVKGKMIMNSLSLFAAISG-MILSIMDILNIKISHFLKMESLNF-IRAH 158
ATEK K LV ++ + LS +A+ G +ILS+ S +++ N R++
Sbjct: 102 SIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSY 161
Query: 159 TPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKR 218
Y +S T CY+ ++ G LS+MLI + + WK+
Sbjct: 162 VSYF-----------YHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQ 210
Query: 219 TCSRPKSNIVLL 230
S +++ L
Sbjct: 211 AYSDFPGSVLFL 222
>gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A
isoform 2 [Homo sapiens]
Length = 225
Score = 55.8 bits (133), Expect = 4e-08
Identities = 50/183 (27%), Positives = 83/183 (45%), Gaps = 22/183 (12%)
Query: 48 ESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVW-------YPLWGGIMYIISGSL 100
E K +G +QI+ G+ ++LG +++ + ++P V YP G +IISGSL
Sbjct: 44 EIKVIGTIQILCGMMVLSLG--IILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSL 101
Query: 101 LAATEKNSRKCLVKGKMIMNSLSLFAAISG-MILSIMDILNIKISHFLKMESLNF-IRAH 158
ATEK K LV ++ + LS +A+ G +ILS+ S +++ N R++
Sbjct: 102 SIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSY 161
Query: 159 TPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKR 218
Y +S T CY+ ++ G LS+MLI + + WK+
Sbjct: 162 VSYF-----------YHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQ 210
Query: 219 TCS 221
S
Sbjct: 211 AYS 213
>gi|169202868 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 53.9 bits (128), Expect = 2e-07
Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 4/99 (4%)
Query: 54 AVQIMNGLFHIALGGLLMIPAGIYAPICVTV-WYPLWGGIMYIISGSLLAATEKNSRKCL 112
A+QI+ GL HI + P Y P + YPLWGG+ YI+SGSL K+ C+
Sbjct: 151 AIQILIGLTHIFSA---INPVLYYYPFVTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCV 207
Query: 113 VKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMES 151
V + N +S A +G+ + I D+ ++ + K S
Sbjct: 208 VNSSISFNIISALFAFAGIFIIITDLSLYYVTTYSKAVS 246
>gi|169203526 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 53.9 bits (128), Expect = 2e-07
Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 4/99 (4%)
Query: 54 AVQIMNGLFHIALGGLLMIPAGIYAPICVTV-WYPLWGGIMYIISGSLLAATEKNSRKCL 112
A+QI+ GL HI + P Y P + YPLWGG+ YI+SGSL K+ C+
Sbjct: 151 AIQILIGLTHIFSA---INPVLYYYPFVTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCV 207
Query: 113 VKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMES 151
V + N +S A +G+ + I D+ ++ + K S
Sbjct: 208 VNSSISFNIISALFAFAGIFIIITDLSLYYVTTYSKAVS 246
>gi|169202217 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 53.9 bits (128), Expect = 2e-07
Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 4/99 (4%)
Query: 54 AVQIMNGLFHIALGGLLMIPAGIYAPICVTV-WYPLWGGIMYIISGSLLAATEKNSRKCL 112
A+QI+ GL HI + P Y P + YPLWGG+ YI+SGSL K+ C+
Sbjct: 151 AIQILIGLTHIFSA---INPVLYYYPFVTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCV 207
Query: 113 VKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMES 151
V + N +S A +G+ + I D+ ++ + K S
Sbjct: 208 VNSSISFNIISALFAFAGIFIIITDLSLYYVTTYSKAVS 246
>gi|22749421 membrane-spanning 4-domains, subfamily A, member 15
isoform 2 [Homo sapiens]
Length = 147
Score = 53.9 bits (128), Expect = 2e-07
Identities = 25/51 (49%), Positives = 32/51 (62%)
Query: 87 PLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMD 137
P WGG +IISGSL A EKN CLV+ + N LS+ AA +G + +MD
Sbjct: 17 PFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMD 67
>gi|167466260 membrane-spanning 4-domains, subfamily A, member 10
[Homo sapiens]
Length = 267
Score = 53.1 bits (126), Expect = 3e-07
Identities = 32/90 (35%), Positives = 45/90 (50%), Gaps = 2/90 (2%)
Query: 50 KTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSR 109
K LGA I L H+ GG L + + WYP WG ++ISG +LA T K
Sbjct: 58 KELGAFHITIALLHLVFGGYLASIVKNLHLVVLKSWYPFWGAASFLISG-ILAITMKTFS 116
Query: 110 KCLVKGKMIM-NSLSLFAAISGMILSIMDI 138
K +K +M N +SLF +SG+ + D+
Sbjct: 117 KTYLKMLCLMTNLISLFCVLSGLFVISKDL 146
>gi|119226217 membrane-spanning 4-domains, subfamily A, member 14
isoform 1 [Homo sapiens]
Length = 679
Score = 49.7 bits (117), Expect = 3e-06
Identities = 37/109 (33%), Positives = 55/109 (50%), Gaps = 9/109 (8%)
Query: 31 FRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALG---GLLMIPAGIYAPICVTVWYP 87
+R SSL+ F E + LGA QI+ L + G L I P+ V YP
Sbjct: 28 YRPHSSLL----DFLKGEPRVLGATQILLALIIVGFGTIFALNYIGFSQRLPLVVLTGYP 83
Query: 88 LWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIM 136
WG +++I++G L T+K S K L +G MN +S AI+G+ +I+
Sbjct: 84 FWGALIFILTG-YLTVTDKKS-KLLGQGVTGMNVISSLVAITGITFTIL 130
>gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A
isoform 3 [Homo sapiens]
Length = 178
Score = 49.7 bits (117), Expect = 3e-06
Identities = 31/93 (33%), Positives = 50/93 (53%), Gaps = 9/93 (9%)
Query: 48 ESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVW-------YPLWGGIMYIISGSL 100
E K +G +QI+ G+ ++LG +++ + ++P V YP G +IISGSL
Sbjct: 44 EIKVIGTIQILCGMMVLSLG--IILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSL 101
Query: 101 LAATEKNSRKCLVKGKMIMNSLSLFAAISGMIL 133
ATEK K LV ++ + LS +A+ G I+
Sbjct: 102 SIATEKRLTKLLVHSSLVGSILSALSALVGFII 134
>gi|4503677 membrane-spanning 4-domains, subfamily A, member 2
isoform 1 [Homo sapiens]
Length = 244
Score = 44.7 bits (104), Expect = 1e-04
Identities = 45/191 (23%), Positives = 78/191 (40%), Gaps = 34/191 (17%)
Query: 13 PAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLM- 71
P E G + + PL ++ L +E + LG QI+ + + G ++
Sbjct: 30 PQEVSSGRLLKSASSPPLHTWLTVL--------KKEQEFLGVTQILTAMICLCFGTVVCS 81
Query: 72 ------IPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLF 125
I I++ YP WG I + ISG L +E+ + LV+G + N+ S
Sbjct: 82 VLDISHIEGDIFSSF--KAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSI 139
Query: 126 AAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYS 185
A +G+ + I+N+K S YI+I++C+ ++ S
Sbjct: 140 AGGTGITIL---IINLKKS--------------LAYIHIHSCQKFFETKCFMASFSTEIV 182
Query: 186 IQSLFLGILSV 196
+ LFL IL +
Sbjct: 183 VMMLFLTILGL 193
>gi|214831008 membrane-spanning 4-domains, subfamily A, member 2
isoform 2 [Homo sapiens]
Length = 195
Score = 43.5 bits (101), Expect = 2e-04
Identities = 38/154 (24%), Positives = 66/154 (42%), Gaps = 27/154 (17%)
Query: 13 PAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLM- 71
P E G + + PL ++ L +E + LG QI+ + + G ++
Sbjct: 30 PQEVSSGRLLKSASSPPLHTWLTVL--------KKEQEFLGVTQILTAMICLCFGTVVCS 81
Query: 72 ------IPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLF 125
I I++ YP WG I + ISG L +E+ + LV+G + N+ S
Sbjct: 82 VLDISHIEGDIFSSF--KAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSI 139
Query: 126 AAISGMILSIMDILNIKISHFLKMESLNFIRAHT 159
A +G+ + I+N+K +SL +I H+
Sbjct: 140 AGGTGITIL---IINLK-------KSLAYIHIHS 163
>gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 42.4 bits (98), Expect = 5e-04
Identities = 50/203 (24%), Positives = 84/203 (41%), Gaps = 28/203 (13%)
Query: 48 ESKTLGAVQIMNGLFHIALGGLLMI---PAGIYAPICVTVW--YPLWGGIMYIISGSLLA 102
E+ LG VQI+ L +LG +L+ P+ I T+ YP G + + I+GSL
Sbjct: 44 ETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSI 103
Query: 103 ATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKI------SHFLKMESLNFIR 156
+ K S K + N++S A +G+ L ++ ++ S + SL +
Sbjct: 104 ISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSE 163
Query: 157 AHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEW 216
+ P I +C + S G+L VMLIF + L+ A W
Sbjct: 164 YYYPIYEIKDCLLTSVS----------------LTGVLVVMLIFTVLELLLAAYSSVFWW 207
Query: 217 KRTCS-RPKSNIVLLSAEEKKEQ 238
K+ S P S+ +++ +Q
Sbjct: 208 KQLYSNNPGSSFSSTQSQDHIQQ 230
>gi|46249357 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 42.4 bits (98), Expect = 5e-04
Identities = 50/203 (24%), Positives = 84/203 (41%), Gaps = 28/203 (13%)
Query: 48 ESKTLGAVQIMNGLFHIALGGLLMI---PAGIYAPICVTVW--YPLWGGIMYIISGSLLA 102
E+ LG VQI+ L +LG +L+ P+ I T+ YP G + + I+GSL
Sbjct: 44 ETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSI 103
Query: 103 ATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKI------SHFLKMESLNFIR 156
+ K S K + N++S A +G+ L ++ ++ S + SL +
Sbjct: 104 ISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSE 163
Query: 157 AHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEW 216
+ P I +C + S G+L VMLIF + L+ A W
Sbjct: 164 YYYPIYEIKDCLLTSVS----------------LTGVLVVMLIFTVLELLLAAYSSVFWW 207
Query: 217 KRTCS-RPKSNIVLLSAEEKKEQ 238
K+ S P S+ +++ +Q
Sbjct: 208 KQLYSNNPGSSFSSTQSQDHIQQ 230
>gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
isoform a [Homo sapiens]
Length = 214
Score = 41.6 bits (96), Expect = 8e-04
Identities = 43/215 (20%), Positives = 78/215 (36%), Gaps = 31/215 (14%)
Query: 19 GPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALG---GLLMIPAG 75
G ++GP+ L + + + + + + LGA+QI+N +ALG G L P
Sbjct: 18 GTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYH 77
Query: 76 IYAPICVTVWY---PLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMI 132
+Y P+WG + + SG+L + ++ MN S A+ G
Sbjct: 78 FQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTA 137
Query: 133 LSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLG 192
++I +NI + + S S S C + S+ G
Sbjct: 138 FLSLNIA----------------------VNIQSLRSCHSS---SESPDLCNYMGSISNG 172
Query: 193 ILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNI 227
++S++LI + V + C + I
Sbjct: 173 MVSLLLILTLLELCVTISTIAMWCNANCCNSREEI 207
>gi|155029533 membrane-spanning 4-domains, subfamily A, member 13
isoform 1 [Homo sapiens]
Length = 152
Score = 39.7 bits (91), Expect = 0.003
Identities = 29/108 (26%), Positives = 50/108 (46%), Gaps = 14/108 (12%)
Query: 58 MNGLFHIALGGLLMI--------PAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSR 109
M G+FHI + L++ G Y P+ LWG I +II+G L K
Sbjct: 1 MIGIFHIFMWYFLLVLYMGQIKGAFGTYEPVTYKTGCTLWG-IFFIIAGVFLIRVTKYPT 59
Query: 110 KCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRA 157
+ + +I+N + + I+ + L+I I++SHF + N+ +A
Sbjct: 60 RSGIISTLIINIICIITTITAVTLTI-----IELSHFNSVSYRNYGQA 102
>gi|21361639 DIPB protein [Homo sapiens]
Length = 344
Score = 36.6 bits (83), Expect = 0.027
Identities = 22/65 (33%), Positives = 37/65 (56%), Gaps = 1/65 (1%)
Query: 232 AEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEE-EEETETNFPEPPQDQESSP 290
AE K EQ EI+ E +E+ + ++EE+ E E+E +EE+E + E +D++ S
Sbjct: 81 AEVKVEQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESE 140
Query: 291 IENDS 295
E D+
Sbjct: 141 AEEDN 145
Score = 29.6 bits (65), Expect = 3.3
Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 5/64 (7%)
Query: 232 AEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPI 291
+E ++E E + E +E S ++EED E EE E+E E+ E Q++ S
Sbjct: 99 SESEEESESEEESETEEESEDESDEESEEDSE-----EEMEDEQESEAEEDNQEEGESEA 153
Query: 292 ENDS 295
E ++
Sbjct: 154 EGET 157
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 36.2 bits (82), Expect = 0.036
Identities = 23/69 (33%), Positives = 33/69 (47%)
Query: 226 NIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQD 285
NI EE++E+ E +EE E + + E++ E +EEEEEE E F E +
Sbjct: 882 NINSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGE 941
Query: 286 QESSPIEND 294
E E D
Sbjct: 942 LEEEEEEED 950
Score = 32.7 bits (73), Expect = 0.39
Identities = 17/44 (38%), Positives = 26/44 (59%)
Query: 244 EEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQE 287
EE + + +S + EE+ E +EEEEEE E +F E +D+E
Sbjct: 875 EEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEE 918
Score = 29.3 bits (64), Expect = 4.4
Identities = 16/42 (38%), Positives = 22/42 (52%), Gaps = 3/42 (7%)
Query: 256 PKNEEDIEIIPI---QEEEEEETETNFPEPPQDQESSPIEND 294
P EED+ +I I EEEEEE E E +++E E +
Sbjct: 872 PALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEE 913
Score = 28.5 bits (62), Expect = 7.4
Identities = 16/58 (27%), Positives = 32/58 (55%), Gaps = 3/58 (5%)
Query: 236 KEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETE---TNFPEPPQDQESSP 290
+E+T + ++V ET ++ + E + E +QE+E+++T +F + P D E P
Sbjct: 1066 EEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEKPP 1123
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 34.7 bits (78), Expect = 0.10
Identities = 25/74 (33%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 224 KSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPP 283
KS + EE+ E+T ++ EEV E + K EE E +EEE E E PP
Sbjct: 449 KSEKETVIVEEQTEET-QVTEEVT--EEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPP 505
Query: 284 QDQESSPIENDSSP 297
++ +SP + SP
Sbjct: 506 AEEAASPEKEAKSP 519
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 34.3 bits (77), Expect = 0.14
Identities = 24/85 (28%), Positives = 39/85 (45%), Gaps = 8/85 (9%)
Query: 212 VENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEE 271
+ + ++T S S+ S E++E+ E +EE +E S + + EE EEE
Sbjct: 257 ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE--------EEE 308
Query: 272 EEETETNFPEPPQDQESSPIENDSS 296
EEET +N E + E + S
Sbjct: 309 EEETGSNSEEASEQSAEEVSEEEMS 333
Score = 29.3 bits (64), Expect = 4.4
Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Query: 234 EKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNF---PEPPQDQESSP 290
E++E+ E +EE G + ++ E++ + E+EE E E + PE D++S
Sbjct: 299 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 358
Query: 291 IE 292
E
Sbjct: 359 SE 360
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,716,935
Number of Sequences: 37866
Number of extensions: 530641
Number of successful extensions: 5114
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 3862
Number of HSP's gapped (non-prelim): 884
length of query: 297
length of database: 18,247,518
effective HSP length: 102
effective length of query: 195
effective length of database: 14,385,186
effective search space: 2805111270
effective search space used: 2805111270
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.