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Search of human proteins with 23097240
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23097240 leucine-rich repeats and WD repeat domain
containing 1 [Homo sapiens]
(647 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23097240 leucine-rich repeats and WD repeat domain containing... 1311 0.0
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 55 3e-07
gi|62912474 leucine-rich repeat-containing G protein-coupled rec... 51 4e-06
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 48 2e-05
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 48 3e-05
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 47 4e-05
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 47 4e-05
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 47 7e-05
gi|4557467 excision repair cross-complementing rodent repair def... 46 9e-05
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 46 9e-05
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 45 2e-04
gi|238908508 leucine-rich repeat and death domain-containing pro... 44 5e-04
gi|53828918 Rab geranylgeranyltransferase alpha [Homo sapiens] 44 6e-04
gi|33469951 Rab geranylgeranyltransferase alpha [Homo sapiens] 44 6e-04
gi|40254924 leucine rich repeat containing 59 [Homo sapiens] 44 6e-04
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 44 6e-04
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 44 6e-04
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 44 6e-04
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 44 6e-04
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 43 0.001
gi|225579152 insulin-like growth factor binding protein, acid la... 42 0.001
gi|4826772 insulin-like growth factor binding protein, acid labi... 42 0.001
gi|19913367 transducin beta-like 1Y [Homo sapiens] 42 0.001
gi|19913365 transducin beta-like 1Y [Homo sapiens] 42 0.001
gi|15150805 transducin beta-like 1Y [Homo sapiens] 42 0.001
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 42 0.001
gi|113865883 WD repeat domain 38 [Homo sapiens] 42 0.002
gi|53729363 leucine rich repeat and sterile alpha motif containi... 42 0.002
gi|53729361 leucine rich repeat and sterile alpha motif containi... 42 0.002
gi|53729359 leucine rich repeat and sterile alpha motif containi... 42 0.002
>gi|23097240 leucine-rich repeats and WD repeat domain containing 1
[Homo sapiens]
Length = 647
Score = 1311 bits (3394), Expect = 0.0
Identities = 647/647 (100%), Positives = 647/647 (100%)
Query: 1 MGPLSARLLMQRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLE 60
MGPLSARLLMQRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLE
Sbjct: 1 MGPLSARLLMQRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLE 60
Query: 61 TLPDNLGLSHLRVLRCANNQLGDVTALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTLR 120
TLPDNLGLSHLRVLRCANNQLGDVTALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTLR
Sbjct: 61 TLPDNLGLSHLRVLRCANNQLGDVTALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTLR 120
Query: 121 KVNGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYG 180
KVNGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYG
Sbjct: 121 KVNGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYG 180
Query: 181 PESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHKPRARLAALKRPDDVPL 240
PESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHKPRARLAALKRPDDVPL
Sbjct: 181 PESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHKPRARLAALKRPDDVPL 240
Query: 241 SLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAF 300
SLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAF
Sbjct: 241 SLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAF 300
Query: 301 EPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKK 360
EPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKK
Sbjct: 301 EPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKK 360
Query: 361 RWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILW 420
RWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILW
Sbjct: 361 RWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILW 420
Query: 421 DIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKR 480
DIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKR
Sbjct: 421 DIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKR 480
Query: 481 RVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVA 540
RVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVA
Sbjct: 481 RVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVA 540
Query: 541 VVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPT 600
VVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPT
Sbjct: 541 VVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPT 600
Query: 601 QILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM 647
QILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM
Sbjct: 601 QILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM 647
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 54.7 bits (130), Expect = 3e-07
Identities = 53/167 (31%), Positives = 81/167 (48%), Gaps = 28/167 (16%)
Query: 40 PKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQLGDV-TALCQFPKLEELS 97
P+ + +L L+EL + NNHLE LP +LG + +L VL C +N L + A+CQ L+EL
Sbjct: 391 PEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELR 450
Query: 98 LEGNPFLTVND------NLKVSFLL-------PTLRKVNGKDASSTYSQVENLNRE-LTS 143
LE N + + NLKV L+ P G +A Y + EN NR + +
Sbjct: 451 LEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLK-ENRNRNIMAT 509
Query: 144 RVTAHWE---------KFMATLGPEEEAEKAQADFVKSAVRDVRYGP 181
++ A W KF L P+++ + + D K +DV+ P
Sbjct: 510 KIQAWWRGTMVQRGFGKFGELLKPQKKGKTSPKD--KKGKKDVKGKP 554
Score = 38.5 bits (88), Expect = 0.019
Identities = 47/156 (30%), Positives = 68/156 (43%), Gaps = 33/156 (21%)
Query: 15 PKS-DRLGKIRSLDLSGLELLSEHLDPKLLCR-----------------------LTQLQ 50
PKS L K+ + LSG L P+L+CR L L+
Sbjct: 250 PKSFAELRKMTEIGLSGNRLEKV---PRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLR 306
Query: 51 ELDLSNNHLETLPDNL-GLSHLRVLRCANNQLGDV-TALCQFPKLEELSLEGNPFLTVND 108
LDLS NHL P + L +L VL +N++G + + L KL+ L L GN FL+ +
Sbjct: 307 FLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPE 366
Query: 109 NLKVSFLLPTLRKVN-GKDASSTYSQVENLNRELTS 143
+ L +L K+ G+D + V R+L S
Sbjct: 367 EV---LSLASLEKLYIGQDQGFKLTYVPEHIRKLQS 399
Score = 36.2 bits (82), Expect = 0.097
Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 3/78 (3%)
Query: 40 PKLLCRLTQLQELDLSNNHLETLPDNL-GLSHLRVLRCANNQLGDV-TALCQFPKLEELS 97
P + T+L+E+ L NN +E +P + L ++RVL N L + AL LE L
Sbjct: 41 PLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLD 100
Query: 98 LEGNPFLTVNDNLKVSFL 115
L NP + + + VSFL
Sbjct: 101 LSYNPIFS-SSLVVVSFL 117
Score = 34.7 bits (78), Expect = 0.28
Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 2/64 (3%)
Query: 40 PKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQLGDVTA-LCQFPKLEELS 97
P+ LC L L+ +DL N + +P+ +G L+ L+ A+N L + A LCQ +L L
Sbjct: 181 PQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLD 240
Query: 98 LEGN 101
L N
Sbjct: 241 LSHN 244
Score = 31.2 bits (69), Expect = 3.1
Identities = 21/61 (34%), Positives = 33/61 (54%), Gaps = 2/61 (3%)
Query: 40 PKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQLGDVTAL-CQFPKLEELS 97
P LC+ +QL LDLS+N L ++P + L + + + N+L V L C++ L L
Sbjct: 227 PASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLY 286
Query: 98 L 98
L
Sbjct: 287 L 287
>gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
Length = 828
Score = 50.8 bits (120), Expect = 4e-06
Identities = 39/101 (38%), Positives = 48/101 (47%), Gaps = 8/101 (7%)
Query: 5 SARLLMQRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPD 64
SAR R S R G R L ++ L L P L L L+EL LS NHL +P
Sbjct: 9 SARAGQNLSRAGSARRGAPRDLSMNNLT----ELQPGLFHHLRFLEELRLSGNHLSHIPG 64
Query: 65 NL--GLSHLRVLRCANNQLGDV--TALCQFPKLEELSLEGN 101
GL L++L NNQLG + AL + P L+ L L N
Sbjct: 65 QAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYN 105
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/91 (32%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 13 GRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNL--GLSH 70
GR L K+ +L L+G + E D K T L+ L L+ + LP + L
Sbjct: 158 GRSAFQYLPKLHTLSLNGAMDIQEFPDLK---GTTSLEILTLTRAGIRLLPSGMCQQLPR 214
Query: 71 LRVLRCANNQLGDVTALCQFPKLEELSLEGN 101
LRVL ++NQ+ ++ +L + KLEE+ L+ N
Sbjct: 215 LRVLELSHNQIEELPSLHRCQKLEEIGLQHN 245
Score = 35.8 bits (81), Expect = 0.13
Identities = 30/88 (34%), Positives = 43/88 (48%), Gaps = 6/88 (6%)
Query: 13 GRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLP--DNLGLSH 70
G +L +++LDLS + S H P+ L L +LDL++N L TLP GL H
Sbjct: 251 GADTFSQLSSLQALDLSWNAIRSIH--PEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMH 308
Query: 71 LRVLRCANNQLGDVTALCQFPKLEELSL 98
L++ N L + FPKL L +
Sbjct: 309 LKLK--GNLALSQAFSKDSFPKLRILEV 334
Score = 32.3 bits (72), Expect = 1.4
Identities = 31/107 (28%), Positives = 50/107 (46%), Gaps = 8/107 (7%)
Query: 2 GPLSARLLM----QRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNN 57
G S ++LM Q G ++ L ++ SL L P + L +LQEL NN
Sbjct: 69 GLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNN 128
Query: 58 HLETLPDN--LGLSHLRVLRCANNQLGDV--TALCQFPKLEELSLEG 100
+++ +P+ +G L+ + +N + V +A PKL LSL G
Sbjct: 129 NIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 175
Score = 30.8 bits (68), Expect = 4.1
Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 8/89 (8%)
Query: 22 KIRSLDLSGLELLSEHLDPKLLCR-LTQLQELDLSNNHLETLPDNLGLSHLRVLRCANNQ 80
+I +L +G+ LL P +C+ L +L+ L+LS+N +E LP L + +N+
Sbjct: 192 EILTLTRAGIRLL-----PSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 246
Query: 81 LGDVTA--LCQFPKLEELSLEGNPFLTVN 107
+ ++ A Q L+ L L N +++
Sbjct: 247 IWEIGADTFSQLSSLQALDLSWNAIRSIH 275
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/90 (34%), Positives = 49/90 (54%), Gaps = 5/90 (5%)
Query: 23 IRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQL 81
++SL L+ +L + P +C L +L+ L L+NNHL LP G LS L+ L + NQL
Sbjct: 64 LKSLSLNNNKLT---VLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQL 120
Query: 82 GDV-TALCQFPKLEELSLEGNPFLTVNDNL 110
G + LC L+ + L N ++ D++
Sbjct: 121 GALPPQLCSLRHLDVMDLSKNQIRSIPDSV 150
Score = 45.8 bits (107), Expect = 1e-04
Identities = 31/81 (38%), Positives = 45/81 (55%), Gaps = 4/81 (4%)
Query: 23 IRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNL-GLSHLRVLRCANNQL 81
+R++DLS ++ E L P L+ + T L+ L L+NN L LPD + L L L NN L
Sbjct: 40 LRTIDLSNNKI--ESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHL 97
Query: 82 GDV-TALCQFPKLEELSLEGN 101
++ + Q L+ LSL GN
Sbjct: 98 RELPSTFGQLSALKTLSLSGN 118
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/84 (32%), Positives = 46/84 (54%), Gaps = 4/84 (4%)
Query: 19 RLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLGLSHLRVLRCAN 78
+L +++L LSG +L + P LC L L +DLS N + ++PD++G + L
Sbjct: 106 QLSALKTLSLSGNQLGAL---PPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQ 162
Query: 79 NQLGDVTA-LCQFPKLEELSLEGN 101
NQ+ ++ + P+L+ L LE N
Sbjct: 163 NQISQISVKISCCPRLKILRLEEN 186
Score = 35.0 bits (79), Expect = 0.22
Identities = 27/66 (40%), Positives = 37/66 (56%), Gaps = 4/66 (6%)
Query: 40 PKLLCRLTQ-LQELDLSNNHLETLPDNL--GLSHLRVLRCANNQLGDV-TALCQFPKLEE 95
P L +LT L+ +DLSNN +E+LP L + L+ L NN+L + +C KLE
Sbjct: 30 PADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLET 89
Query: 96 LSLEGN 101
LSL N
Sbjct: 90 LSLNNN 95
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 47.8 bits (112), Expect = 3e-05
Identities = 35/80 (43%), Positives = 45/80 (56%), Gaps = 6/80 (7%)
Query: 26 LDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNL--GLSHLRVLRCANNQLGD 83
LDLS + L+E L P L L L+EL LS NHL +P GL L++L NNQLG
Sbjct: 71 LDLS-MNNLTE-LQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGG 128
Query: 84 V--TALCQFPKLEELSLEGN 101
+ AL + P L+ L L+ N
Sbjct: 129 IPAEALWELPSLQSLRLDAN 148
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/91 (32%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 13 GRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNL--GLSH 70
GR L K+ +L L+G + E D K T L+ L L+ + LP + L
Sbjct: 297 GRSAFQYLPKLHTLSLNGAMDIQEFPDLK---GTTSLEILTLTRAGIRLLPSGMCQQLPR 353
Query: 71 LRVLRCANNQLGDVTALCQFPKLEELSLEGN 101
LRVL ++NQ+ ++ +L + KLEE+ L+ N
Sbjct: 354 LRVLELSHNQIEELPSLHRCQKLEEIGLQHN 384
Score = 35.8 bits (81), Expect = 0.13
Identities = 30/88 (34%), Positives = 43/88 (48%), Gaps = 6/88 (6%)
Query: 13 GRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLP--DNLGLSH 70
G +L +++LDLS + S H P+ L L +LDL++N L TLP GL H
Sbjct: 390 GADTFSQLSSLQALDLSWNAIRSIH--PEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMH 447
Query: 71 LRVLRCANNQLGDVTALCQFPKLEELSL 98
L++ N L + FPKL L +
Sbjct: 448 LKLK--GNLALSQAFSKDSFPKLRILEV 473
Score = 30.8 bits (68), Expect = 4.1
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 7/92 (7%)
Query: 13 GRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDN--LGLSH 70
G + L + +LDL+ +L P + L +LQEL NN+++ +P+ +G
Sbjct: 226 GTHSFEGLHNLETLDLNYNKLQEF---PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPL 282
Query: 71 LRVLRCANNQLGDV--TALCQFPKLEELSLEG 100
L+ + +N + V +A PKL LSL G
Sbjct: 283 LQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 314
Score = 30.8 bits (68), Expect = 4.1
Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 8/89 (8%)
Query: 22 KIRSLDLSGLELLSEHLDPKLLCR-LTQLQELDLSNNHLETLPDNLGLSHLRVLRCANNQ 80
+I +L +G+ LL P +C+ L +L+ L+LS+N +E LP L + +N+
Sbjct: 331 EILTLTRAGIRLL-----PSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 385
Query: 81 LGDVTA--LCQFPKLEELSLEGNPFLTVN 107
+ ++ A Q L+ L L N +++
Sbjct: 386 IWEIGADTFSQLSSLQALDLSWNAIRSIH 414
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 47.4 bits (111), Expect = 4e-05
Identities = 35/96 (36%), Positives = 51/96 (53%), Gaps = 8/96 (8%)
Query: 13 GRPKSDRLGKIRSLDLSGLELLSEHL---DPKLLCRLTQLQELDLSNNHLETLPDNL--G 67
GRP+ + ++ S+ +S +L +L P L L L+EL LS NHL +P G
Sbjct: 2 GRPRLTLVCQV-SIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSG 60
Query: 68 LSHLRVLRCANNQLGDV--TALCQFPKLEELSLEGN 101
L L++L NNQLG + AL + P L+ L L+ N
Sbjct: 61 LYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDAN 96
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/91 (32%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 13 GRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNL--GLSH 70
GR L K+ +L L+G + E D K T L+ L L+ + LP + L
Sbjct: 245 GRSAFQYLPKLHTLSLNGAMDIQEFPDLK---GTTSLEILTLTRAGIRLLPSGMCQQLPR 301
Query: 71 LRVLRCANNQLGDVTALCQFPKLEELSLEGN 101
LRVL ++NQ+ ++ +L + KLEE+ L+ N
Sbjct: 302 LRVLELSHNQIEELPSLHRCQKLEEIGLQHN 332
Score = 35.8 bits (81), Expect = 0.13
Identities = 30/88 (34%), Positives = 43/88 (48%), Gaps = 6/88 (6%)
Query: 13 GRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLP--DNLGLSH 70
G +L +++LDLS + S H P+ L L +LDL++N L TLP GL H
Sbjct: 338 GADTFSQLSSLQALDLSWNAIRSIH--PEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMH 395
Query: 71 LRVLRCANNQLGDVTALCQFPKLEELSL 98
L++ N L + FPKL L +
Sbjct: 396 LKLK--GNLALSQAFSKDSFPKLRILEV 421
Score = 30.8 bits (68), Expect = 4.1
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 7/92 (7%)
Query: 13 GRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDN--LGLSH 70
G + L + +LDL+ +L P + L +LQEL NN+++ +P+ +G
Sbjct: 174 GTHSFEGLHNLETLDLNYNKLQEF---PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPL 230
Query: 71 LRVLRCANNQLGDV--TALCQFPKLEELSLEG 100
L+ + +N + V +A PKL LSL G
Sbjct: 231 LQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 262
Score = 30.8 bits (68), Expect = 4.1
Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 8/89 (8%)
Query: 22 KIRSLDLSGLELLSEHLDPKLLCR-LTQLQELDLSNNHLETLPDNLGLSHLRVLRCANNQ 80
+I +L +G+ LL P +C+ L +L+ L+LS+N +E LP L + +N+
Sbjct: 279 EILTLTRAGIRLL-----PSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 333
Query: 81 LGDVTA--LCQFPKLEELSLEGNPFLTVN 107
+ ++ A Q L+ L L N +++
Sbjct: 334 IWEIGADTFSQLSSLQALDLSWNAIRSIH 362
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 47.4 bits (111), Expect = 4e-05
Identities = 31/89 (34%), Positives = 48/89 (53%), Gaps = 4/89 (4%)
Query: 15 PKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLGLSHLRVL 74
P LG +R LD+S EL S P LC L+ L++L++ N L TLP+ LG L L
Sbjct: 153 PDIGTLGSLRQLDVSSNELQSL---PSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRL 209
Query: 75 RCANNQLGDV-TALCQFPKLEELSLEGNP 102
+ N++ + + C+ L+ + L+ NP
Sbjct: 210 DFSCNRVSRIPVSFCRLRHLQVILLDSNP 238
Score = 38.9 bits (89), Expect = 0.015
Identities = 30/93 (32%), Positives = 48/93 (51%), Gaps = 3/93 (3%)
Query: 20 LGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCAN 78
LG + +L L L P +C+L L+ L +SNN L LP ++G L LR L ++
Sbjct: 110 LGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSS 168
Query: 79 NQLGDV-TALCQFPKLEELSLEGNPFLTVNDNL 110
N+L + + LC L +L++ N T+ + L
Sbjct: 169 NELQSLPSELCGLSSLRDLNVRRNQLSTLPEEL 201
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 46.6 bits (109), Expect = 7e-05
Identities = 36/89 (40%), Positives = 50/89 (56%), Gaps = 5/89 (5%)
Query: 15 PKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLGLS-HLRV 73
P+ RL +R L L+ +L + L P++ L +LQ LD+S N L TLP+ L + L+
Sbjct: 105 PEIGRLRALRHLRLANNQL--QFLPPEV-GDLKELQTLDISTNRLLTLPERLHMCLSLQY 161
Query: 74 LRCANNQLGDVTA-LCQFPKLEELSLEGN 101
L N+L V LCQ P L ELS+ GN
Sbjct: 162 LTVDRNRLWYVPRHLCQLPSLNELSMAGN 190
Score = 38.5 bits (88), Expect = 0.019
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 40 PKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQLGDV-TALCQFPKLEELS 97
P+ + L +LQ LDLS+N LE + +G L LR LR ANNQL + + +L+ L
Sbjct: 81 PEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLD 140
Query: 98 LEGNPFLTVNDNLKVSFLLPTL 119
+ N LT+ + L + L L
Sbjct: 141 ISTNRLLTLPERLHMCLSLQYL 162
Score = 30.0 bits (66), Expect = 6.9
Identities = 14/30 (46%), Positives = 19/30 (63%)
Query: 40 PKLLCRLTQLQELDLSNNHLETLPDNLGLS 69
P+ LC+L L EL ++ N L LP +LG S
Sbjct: 173 PRHLCQLPSLNELSMAGNRLAFLPLDLGRS 202
>gi|4557467 excision repair cross-complementing rodent repair
deficiency, complementation group 8 isoform 1 [Homo
sapiens]
Length = 396
Score = 46.2 bits (108), Expect = 9e-05
Identities = 22/59 (37%), Positives = 37/59 (62%), Gaps = 1/59 (1%)
Query: 365 LAAAGLRG-LVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDI 422
L A G RG V+L +++G C +++ H++ I + +SP ++ L TAS D R+ LWD+
Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 46.2 bits (108), Expect = 9e-05
Identities = 29/84 (34%), Positives = 50/84 (59%), Gaps = 5/84 (5%)
Query: 20 LGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNL-GLSHLRVLRCAN 78
L ++R+LD+ +L + P+ L +L L+ELD+S+N L LP+++ L L++L +
Sbjct: 180 LSRLRTLDVDHNQLTAF---PRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSG 236
Query: 79 NQLGDVTA-LCQFPKLEELSLEGN 101
+LG + A C+ LE L L+ N
Sbjct: 237 AELGTLPAGFCELASLESLMLDNN 260
Score = 41.6 bits (96), Expect = 0.002
Identities = 35/84 (41%), Positives = 45/84 (53%), Gaps = 5/84 (5%)
Query: 20 LGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCAN 78
L ++R L+LS +L + P L L L+ELD+S N L LPD+L LS LR L +
Sbjct: 134 LRELRKLNLSHNQLPAL---PAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDH 190
Query: 79 NQL-GDVTALCQFPKLEELSLEGN 101
NQL L Q LEEL + N
Sbjct: 191 NQLTAFPRQLLQLVALEELDVSSN 214
Score = 37.4 bits (85), Expect = 0.043
Identities = 34/98 (34%), Positives = 46/98 (46%), Gaps = 6/98 (6%)
Query: 12 RGRPKS-DRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LS 69
RG P+ L ++ L LSG EL + P C L L+ L L NN L+ LP L
Sbjct: 217 RGLPEDISALRALKILWLSGAELGTL---PAGFCELASLESLMLDNNGLQALPAQFSCLQ 273
Query: 70 HLRVLRCANNQLGDV-TALCQFPKLEELSLEGNPFLTV 106
L++L ++N + AL LEEL L N +V
Sbjct: 274 RLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSV 311
Score = 33.5 bits (75), Expect = 0.63
Identities = 32/102 (31%), Positives = 54/102 (52%), Gaps = 10/102 (9%)
Query: 8 LLMQRGR-----PKSDRLGK-IRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLET 61
L+++R R P LG + LD+S L + L +++ L +L++L+LS+N L
Sbjct: 92 LVLRRNRFARLPPAVAELGHHLTELDVSHNRLTA--LGAEVVSALRELRKLNLSHNQLPA 149
Query: 62 LPDNLG-LSHLRVLRCANNQLGDV-TALCQFPKLEELSLEGN 101
LP LG L+HL L + N+L + +L +L L ++ N
Sbjct: 150 LPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHN 191
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/93 (38%), Positives = 53/93 (56%), Gaps = 5/93 (5%)
Query: 25 SLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQLGD 83
+LD++ +L EHL PK + TQ+ LDL +N L LPD +G LS L L N+L
Sbjct: 242 TLDVAHNQL--EHL-PKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSA 298
Query: 84 V-TALCQFPKLEELSLEGNPFLTVNDNLKVSFL 115
+ +L + LEEL+LE N T+ ++L S +
Sbjct: 299 IPRSLAKCSALEELNLENNNISTLPESLLSSLV 331
Score = 43.9 bits (102), Expect = 5e-04
Identities = 31/88 (35%), Positives = 45/88 (51%), Gaps = 4/88 (4%)
Query: 18 DRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNL--GLSHLRVLR 75
D +G + SL GL P+ L + + L+EL+L NN++ TLP++L L L L
Sbjct: 278 DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLT 337
Query: 76 CANN--QLGDVTALCQFPKLEELSLEGN 101
A N QL V QF + L++E N
Sbjct: 338 LARNCFQLYPVGGPSQFSTIYSLNMEHN 365
Score = 38.9 bits (89), Expect = 0.015
Identities = 34/87 (39%), Positives = 44/87 (50%), Gaps = 5/87 (5%)
Query: 20 LGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCAN 78
L K+R LDL +L S P + L LQ+L L+NN L TLP +G L++L L
Sbjct: 447 LRKLRELDLEENKLESL---PNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGE 503
Query: 79 NQLGDV-TALCQFPKLEELSLEGNPFL 104
N L + + LEEL L NP L
Sbjct: 504 NLLTHLPEEIGTLENLEELYLNDNPNL 530
Score = 35.8 bits (81), Expect = 0.13
Identities = 28/64 (43%), Positives = 37/64 (57%), Gaps = 9/64 (14%)
Query: 27 DLSGLE-----LLSEHLDPKL---LCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCA 77
D+SGL +LS +L KL L L +L+ELDL N LE+LP+ + L L+ L
Sbjct: 420 DVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLT 479
Query: 78 NNQL 81
NNQL
Sbjct: 480 NNQL 483
Score = 35.0 bits (79), Expect = 0.22
Identities = 29/78 (37%), Positives = 40/78 (51%), Gaps = 5/78 (6%)
Query: 26 LDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQLGDV 84
LDLS + H+ P + LTQL EL L +N L++LP +G L +L L + N L +
Sbjct: 105 LDLSKRSI---HILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSL 161
Query: 85 -TALCQFPKLEELSLEGN 101
+L KL L L N
Sbjct: 162 PDSLDNLKKLRMLDLRHN 179
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 43.9 bits (102), Expect = 5e-04
Identities = 26/64 (40%), Positives = 39/64 (60%), Gaps = 2/64 (3%)
Query: 40 PKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQLGDV-TALCQFPKLEELS 97
P L +TQL+ELD+SNN + +P N+G L +L L NNQ+ + +L L++L+
Sbjct: 644 PGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLN 703
Query: 98 LEGN 101
L GN
Sbjct: 704 LSGN 707
Score = 38.1 bits (87), Expect = 0.025
Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 2/96 (2%)
Query: 18 DRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNL-GLSHLRVLRC 76
D L +++L + LE PK LC L +L LDL+ N + +LP + L +L L
Sbjct: 274 DTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLM 333
Query: 77 ANNQLGDVTA-LCQFPKLEELSLEGNPFLTVNDNLK 111
+N+L + + Q K++EL L N ++ ++
Sbjct: 334 DHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIE 369
Score = 36.6 bits (83), Expect = 0.074
Identities = 22/61 (36%), Positives = 35/61 (57%), Gaps = 2/61 (3%)
Query: 40 PKLLCRLTQLQELDLSNNHLETLPDNL-GLSHLRVLRCANNQ-LGDVTALCQFPKLEELS 97
P+ LC L LQ LDLS N L+ + ++ L ++ L ++NQ + LCQ LE+L+
Sbjct: 572 PRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLN 631
Query: 98 L 98
+
Sbjct: 632 I 632
Score = 31.2 bits (69), Expect = 3.1
Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 32/106 (30%)
Query: 26 LDLSGLELL--SEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG---------------- 67
L+LS +LL SEH C L L+ LDL N ++ +P ++
Sbjct: 515 LELSENKLLIFSEHF-----CSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFE 569
Query: 68 --------LSHLRVLRCANNQLGDVTA-LCQFPKLEELSLEGNPFL 104
L +L+VL + NQL +++ +C +++L+ N F+
Sbjct: 570 TFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFI 615
>gi|53828918 Rab geranylgeranyltransferase alpha [Homo sapiens]
Length = 567
Score = 43.5 bits (101), Expect = 6e-04
Identities = 28/69 (40%), Positives = 38/69 (55%), Gaps = 4/69 (5%)
Query: 37 HLDPKLLCRLTQL---QELDLSNNHLETLPDNL-GLSHLRVLRCANNQLGDVTALCQFPK 92
H D +LC L QL LDLS+N L TLP L L L VL+ ++N + + + P+
Sbjct: 450 HKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPR 509
Query: 93 LEELSLEGN 101
L+EL L N
Sbjct: 510 LQELLLCNN 518
Score = 36.6 bits (83), Expect = 0.074
Identities = 33/103 (32%), Positives = 48/103 (46%), Gaps = 13/103 (12%)
Query: 33 LLSEHLD---------PKLLCRLTQLQELDLSNNHLETLPDNLGLSHLRVLRCANNQLGD 83
LL HLD P L L L+ L S+N +E+L L L+ L NN+L
Sbjct: 463 LLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQ 522
Query: 84 ---VTALCQFPKLEELSLEGNPFLTVNDNL-KVSFLLPTLRKV 122
+ L P+L L+L+GNP L +++ LLP++ V
Sbjct: 523 PAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSV 565
>gi|33469951 Rab geranylgeranyltransferase alpha [Homo sapiens]
Length = 567
Score = 43.5 bits (101), Expect = 6e-04
Identities = 28/69 (40%), Positives = 38/69 (55%), Gaps = 4/69 (5%)
Query: 37 HLDPKLLCRLTQL---QELDLSNNHLETLPDNL-GLSHLRVLRCANNQLGDVTALCQFPK 92
H D +LC L QL LDLS+N L TLP L L L VL+ ++N + + + P+
Sbjct: 450 HKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPR 509
Query: 93 LEELSLEGN 101
L+EL L N
Sbjct: 510 LQELLLCNN 518
Score = 36.6 bits (83), Expect = 0.074
Identities = 33/103 (32%), Positives = 48/103 (46%), Gaps = 13/103 (12%)
Query: 33 LLSEHLD---------PKLLCRLTQLQELDLSNNHLETLPDNLGLSHLRVLRCANNQLGD 83
LL HLD P L L L+ L S+N +E+L L L+ L NN+L
Sbjct: 463 LLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQ 522
Query: 84 ---VTALCQFPKLEELSLEGNPFLTVNDNL-KVSFLLPTLRKV 122
+ L P+L L+L+GNP L +++ LLP++ V
Sbjct: 523 PAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSV 565
>gi|40254924 leucine rich repeat containing 59 [Homo sapiens]
Length = 307
Score = 43.5 bits (101), Expect = 6e-04
Identities = 64/223 (28%), Positives = 88/223 (39%), Gaps = 35/223 (15%)
Query: 20 LGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCAN 78
L K LDLS +L + P C LT L +LDLS N L+ LP + G L +L+ L N
Sbjct: 38 LPKATILDLSCNKLTTL---PSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
Query: 79 NQLGDV-TALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTLRKVNGKDASSTYSQVENL 137
N+L + + Q L+ L L+ NP L P L KV G E
Sbjct: 95 NKLVTLPVSFAQLKNLKWLDLKDNP------------LDPVLAKVAGDCLD------EKQ 136
Query: 138 NRELTSRVTAHWEKFMA--------TLGPEEEAEKAQADFVKSAVRDVRYGPESLSEFTQ 189
++ ++V H + A L E EAEK + ++ R + +
Sbjct: 137 CKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEK 196
Query: 190 WRVRMISEELVAASRTQVQK----ANSPEKPPEAGAAHKPRAR 228
R R + L AA R Q +K AN K KP R
Sbjct: 197 ERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPR 239
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 43.5 bits (101), Expect = 6e-04
Identities = 26/123 (21%), Positives = 59/123 (47%), Gaps = 4/123 (3%)
Query: 313 VATCGGEAVCVI-DCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLR 371
+A+C + I + + +H +A +E +++ W+ T + +LA+A
Sbjct: 376 LASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSN--IMLASASFD 433
Query: 372 GLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDIGVPNQDYEF 431
VRL + G C + H++ + ++ FSP + +L + S+DK + +W+ N + +
Sbjct: 434 STVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK-YLASGSFDKCVHIWNTQSGNLVHSY 492
Query: 432 QAS 434
+ +
Sbjct: 493 RGT 495
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 43.5 bits (101), Expect = 6e-04
Identities = 26/123 (21%), Positives = 59/123 (47%), Gaps = 4/123 (3%)
Query: 313 VATCGGEAVCVI-DCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLR 371
+A+C + I + + +H +A +E +++ W+ T + +LA+A
Sbjct: 376 LASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSN--IMLASASFD 433
Query: 372 GLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDIGVPNQDYEF 431
VRL + G C + H++ + ++ FSP + +L + S+DK + +W+ N + +
Sbjct: 434 STVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK-YLASGSFDKCVHIWNTQSGNLVHSY 492
Query: 432 QAS 434
+ +
Sbjct: 493 RGT 495
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 43.5 bits (101), Expect = 6e-04
Identities = 26/123 (21%), Positives = 59/123 (47%), Gaps = 4/123 (3%)
Query: 313 VATCGGEAVCVI-DCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLR 371
+A+C + I + + +H +A +E +++ W+ T + +LA+A
Sbjct: 427 LASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSN--IMLASASFD 484
Query: 372 GLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDIGVPNQDYEF 431
VRL + G C + H++ + ++ FSP + +L + S+DK + +W+ N + +
Sbjct: 485 STVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK-YLASGSFDKCVHIWNTQSGNLVHSY 543
Query: 432 QAS 434
+ +
Sbjct: 544 RGT 546
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 43.5 bits (101), Expect = 6e-04
Identities = 26/123 (21%), Positives = 59/123 (47%), Gaps = 4/123 (3%)
Query: 313 VATCGGEAVCVI-DCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLR 371
+A+C + I + + +H +A +E +++ W+ T + +LA+A
Sbjct: 427 LASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSN--IMLASASFD 484
Query: 372 GLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDIGVPNQDYEF 431
VRL + G C + H++ + ++ FSP + +L + S+DK + +W+ N + +
Sbjct: 485 STVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK-YLASGSFDKCVHIWNTQSGNLVHSY 543
Query: 432 QAS 434
+ +
Sbjct: 544 RGT 546
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 42.7 bits (99), Expect = 0.001
Identities = 29/65 (44%), Positives = 39/65 (60%), Gaps = 4/65 (6%)
Query: 46 LTQLQELDLSNNHL--ETLPDNLGLSHLRVLRCANNQLGDVTA--LCQFPKLEELSLEGN 101
L+ LQ L L+NN L + +P +G HLR+L ANNQL A L + +LEEL+L GN
Sbjct: 619 LSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGN 678
Query: 102 PFLTV 106
T+
Sbjct: 679 KLKTI 683
Score = 33.9 bits (76), Expect = 0.48
Identities = 19/60 (31%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 43 LCRLTQLQELDLSNNHLETLPDNL-GLSHLRVLRCANNQLGDVTALCQFPKLEELSLEGN 101
L +L QL+EL+LS N L+T+P + L L +N + + Q P+++ + L N
Sbjct: 664 LNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCN 723
Score = 32.3 bits (72), Expect = 1.4
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 6/86 (6%)
Query: 19 RLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCA 77
+ +++ L+LS +L L P LLC ++ L EL+LS N LP +G L +L+ L
Sbjct: 297 KFSQLKGLNLSHNKL---GLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLD 353
Query: 78 NNQLGDVTALCQFPKLEELSLEGNPF 103
N L T + L++LS G F
Sbjct: 354 GNFL--TTLPEELGNLQQLSSLGISF 377
Score = 30.0 bits (66), Expect = 6.9
Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 9/101 (8%)
Query: 23 IRSLDLSGLELLSEHLD--PKLLCRLTQLQELDLSNNHLETLPDNL--GLSHLRVLRCAN 78
+ SL L L L H+ P L+ + L+ LDL +N L LPD L +LR L +
Sbjct: 545 LSSLSLRKLMLGHNHVQNLPTLVEHIP-LEVLDLQHNALTRLPDTLFSKALNLRYLNASA 603
Query: 79 NQLGDVTALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTL 119
N L + + C E SL L + +NL +P L
Sbjct: 604 NSLESLPSAC----TGEESLSMLQLLYLTNNLLTDQCIPVL 640
Score = 29.6 bits (65), Expect = 9.0
Identities = 24/76 (31%), Positives = 42/76 (55%), Gaps = 11/76 (14%)
Query: 36 EHLDPKLLCRLTQLQELDLSNNHLETLP-DNL-GLSHLRVLRCANNQLG--DVTALCQFP 91
E L+ +L R+ ++ +DL NHL+T+ +NL G H+ + +N+L D+++LC
Sbjct: 404 EVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLE 463
Query: 92 -------KLEELSLEG 100
+L EL+L G
Sbjct: 464 QLHCGRNQLRELTLSG 479
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/86 (43%), Positives = 44/86 (51%), Gaps = 6/86 (6%)
Query: 20 LGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNL--GLSHLRVLRCA 77
LGK+ L LS L L L L + LD+S+N LE LP++L L LR L
Sbjct: 495 LGKLEYLLLSRNRLAE--LPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLR 552
Query: 78 NNQLGDVTALCQFPKLEELSLEGNPF 103
NN L T Q P LE L LEGNP+
Sbjct: 553 NNSLRTFTP--QPPGLERLWLEGNPW 576
Score = 34.7 bits (78), Expect = 0.28
Identities = 26/82 (31%), Positives = 37/82 (45%), Gaps = 22/82 (26%)
Query: 20 LGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLGLSHLRVLRCANN 79
LG +R L L+G L +L P L L +L+ELDLS N L + N+
Sbjct: 231 LGSLRELVLAGNRLA--YLQPALFSGLAELRELDLSRNALRAIKANV------------- 275
Query: 80 QLGDVTALCQFPKLEELSLEGN 101
Q P+L++L L+ N
Sbjct: 276 -------FVQLPRLQKLYLDRN 290
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/86 (43%), Positives = 44/86 (51%), Gaps = 6/86 (6%)
Query: 20 LGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNL--GLSHLRVLRCA 77
LGK+ L LS L L L L + LD+S+N LE LP++L L LR L
Sbjct: 457 LGKLEYLLLSRNRLAE--LPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLR 514
Query: 78 NNQLGDVTALCQFPKLEELSLEGNPF 103
NN L T Q P LE L LEGNP+
Sbjct: 515 NNSLRTFTP--QPPGLERLWLEGNPW 538
Score = 34.7 bits (78), Expect = 0.28
Identities = 26/82 (31%), Positives = 37/82 (45%), Gaps = 22/82 (26%)
Query: 20 LGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLGLSHLRVLRCANN 79
LG +R L L+G L +L P L L +L+ELDLS N L + N+
Sbjct: 193 LGSLRELVLAGNRLA--YLQPALFSGLAELRELDLSRNALRAIKANV------------- 237
Query: 80 QLGDVTALCQFPKLEELSLEGN 101
Q P+L++L L+ N
Sbjct: 238 -------FVQLPRLQKLYLDRN 252
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/90 (25%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 332 LHKYKAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHVRAGFCCGVIRAH 391
+H +A +E +++ W+ T + +LA+A VRL V G C + H
Sbjct: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSS--IMLASASFDSTVRLWDVEQGVCTHTLMKH 451
Query: 392 KKAIATLCFSPAHETHLFTASYDKRIILWD 421
++ + ++ FSP + +L + S+DK + +W+
Sbjct: 452 QEPVYSVAFSPDGK-YLASGSFDKYVHIWN 480
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/90 (25%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 332 LHKYKAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHVRAGFCCGVIRAH 391
+H +A +E +++ W+ T + +LA+A VRL V G C + H
Sbjct: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSS--IMLASASFDSTVRLWDVEQGVCTHTLMKH 451
Query: 392 KKAIATLCFSPAHETHLFTASYDKRIILWD 421
++ + ++ FSP + +L + S+DK + +W+
Sbjct: 452 QEPVYSVAFSPDGK-YLASGSFDKYVHIWN 480
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/90 (25%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 332 LHKYKAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHVRAGFCCGVIRAH 391
+H +A +E +++ W+ T + +LA+A VRL V G C + H
Sbjct: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSS--IMLASASFDSTVRLWDVEQGVCTHTLMKH 451
Query: 392 KKAIATLCFSPAHETHLFTASYDKRIILWD 421
++ + ++ FSP + +L + S+DK + +W+
Sbjct: 452 QEPVYSVAFSPDGK-YLASGSFDKYVHIWN 480
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 42.4 bits (98), Expect = 0.001
Identities = 38/97 (39%), Positives = 49/97 (50%), Gaps = 9/97 (9%)
Query: 49 LQELDLSNNHLETL-PDNLGLSHLRVLRCANNQLGDVTA----LCQFP---KLEELSLEG 100
LQ LD+S N L L P+ L L LR L NN+LG +A L Q P L+ L+L G
Sbjct: 70 LQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSG 129
Query: 101 NPFLTVNDNLKVSFLLPTLRKVNGKDASSTYSQVENL 137
N F V +L L TL + G S +++ENL
Sbjct: 130 NCFQEVPASLLELRALQTL-SLGGNQLQSIPAEIENL 165
Score = 33.5 bits (75), Expect = 0.63
Identities = 39/112 (34%), Positives = 52/112 (46%), Gaps = 9/112 (8%)
Query: 40 PKLLCRLTQLQELDLSNNHLETLPDNLGLSH-LRVLRCANNQLGDVTA-LCQFPKLEELS 97
P L L L L L +N ++++P L H LR L NN L + + LEELS
Sbjct: 182 PPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELS 241
Query: 98 LEGNPFLTVNDNLKVSFLLPTL-----RKVNGKDASST-YSQVENLNRELTS 143
L GNP L V +++ PTL R + ++ S T Y NL R L S
Sbjct: 242 LRGNP-LVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLRYLGS 292
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 42.0 bits (97), Expect = 0.002
Identities = 20/59 (33%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 364 VLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDI 422
+ A+A VRL V C V++ H++++ T+ FSP L + +DKR++LWD+
Sbjct: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSP-DSRQLASGGWDKRVMLWDV 134
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 18 DRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRC 76
D LG++ +L + +E P+ + LTQLQ L++ +N L+ LPD +G L LR L
Sbjct: 98 DDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNI 157
Query: 77 ANNQLGDV-TALCQFPKLEELSLEGN 101
+ N++ + L LE LSL+ +
Sbjct: 158 SGNEIQRLPQMLAHVRTLEMLSLDAS 183
Score = 34.7 bits (78), Expect = 0.28
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 43 LCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQLGDV-TALCQFPKLEELSLEG 100
L L ++ LDL +N L LPD+LG L+ L+VL NQL + ++ +L+ L+++
Sbjct: 77 LLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKD 136
Query: 101 NPFLTVNDNL 110
N + D +
Sbjct: 137 NKLKELPDTV 146
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 18 DRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRC 76
D LG++ +L + +E P+ + LTQLQ L++ +N L+ LPD +G L LR L
Sbjct: 98 DDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNI 157
Query: 77 ANNQLGDV-TALCQFPKLEELSLEGN 101
+ N++ + L LE LSL+ +
Sbjct: 158 SGNEIQRLPQMLAHVRTLEMLSLDAS 183
Score = 34.7 bits (78), Expect = 0.28
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 43 LCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQLGDV-TALCQFPKLEELSLEG 100
L L ++ LDL +N L LPD+LG L+ L+VL NQL + ++ +L+ L+++
Sbjct: 77 LLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKD 136
Query: 101 NPFLTVNDNL 110
N + D +
Sbjct: 137 NKLKELPDTV 146
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 18 DRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRC 76
D LG++ +L + +E P+ + LTQLQ L++ +N L+ LPD +G L LR L
Sbjct: 98 DDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNI 157
Query: 77 ANNQLGDV-TALCQFPKLEELSLEGN 101
+ N++ + L LE LSL+ +
Sbjct: 158 SGNEIQRLPQMLAHVRTLEMLSLDAS 183
Score = 34.7 bits (78), Expect = 0.28
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 43 LCRLTQLQELDLSNNHLETLPDNLG-LSHLRVLRCANNQLGDV-TALCQFPKLEELSLEG 100
L L ++ LDL +N L LPD+LG L+ L+VL NQL + ++ +L+ L+++
Sbjct: 77 LLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKD 136
Query: 101 NPFLTVNDNL 110
N + D +
Sbjct: 137 NKLKELPDTV 146
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,885,657
Number of Sequences: 37866
Number of extensions: 1210189
Number of successful extensions: 4742
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 160
Number of HSP's that attempted gapping in prelim test: 4174
Number of HSP's gapped (non-prelim): 676
length of query: 647
length of database: 18,247,518
effective HSP length: 109
effective length of query: 538
effective length of database: 14,120,124
effective search space: 7596626712
effective search space used: 7596626712
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.