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Search of human proteins with 226246586
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
(576 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 1208 0.0
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 1153 0.0
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 1047 0.0
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi... 1002 0.0
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 758 0.0
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 758 0.0
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 573 e-163
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 335 9e-92
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 277 2e-74
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 276 4e-74
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 276 4e-74
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 272 5e-73
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 239 5e-63
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 239 5e-63
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 239 5e-63
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens] 70 5e-12
gi|122937514 unc-13 homolog C [Homo sapiens] 69 9e-12
gi|122937247 unc-13 homolog A [Homo sapiens] 69 1e-11
gi|5031689 protein kinase D3 [Homo sapiens] 67 6e-11
gi|5453976 protein kinase C, theta [Homo sapiens] 63 6e-10
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 63 8e-10
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 63 8e-10
gi|47157325 protein kinase C, delta [Homo sapiens] 62 1e-09
gi|31377782 protein kinase C, delta [Homo sapiens] 62 1e-09
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 61 2e-09
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 60 7e-09
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 60 7e-09
gi|13384594 protein kinase C, gamma [Homo sapiens] 60 7e-09
gi|4506067 protein kinase C, alpha [Homo sapiens] 59 9e-09
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 57 5e-08
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 1208 bits (3125), Expect = 0.0
Identities = 576/576 (100%), Positives = 576/576 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITALLELTELLASHNNYARYR 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITALLELTELLASHNNYARYR
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITALLELTELLASHNNYARYR 240
Query: 241 RTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHP 300
RTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHP
Sbjct: 241 RTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHP 300
Query: 301 PCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPK 360
PCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPK
Sbjct: 301 PCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPK 360
Query: 361 PDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFS 420
PDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFS
Sbjct: 361 PDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFS 420
Query: 421 REELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLC 480
REELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLC
Sbjct: 421 REELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLC 480
Query: 481 CHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQL 540
CHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQL
Sbjct: 481 CHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQL 540
Query: 541 RHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 576
RHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 541 RHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 576
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 1153 bits (2983), Expect = 0.0
Identities = 567/639 (88%), Positives = 570/639 (89%), Gaps = 63/639 (9%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGEL----------------------------------- 205
PMSSPGLGKKRKVSLLFDHLETGEL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITVMVLSRPGPLQRAQVLDKF 240
Query: 206 ---AQHLTYLE-FRSFQAIT------------------------ALLELTELLASHNNYA 237
AQ L L+ F + A+T ALLELTELLASHNNYA
Sbjct: 241 IHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYA 300
Query: 238 RYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQG 297
RYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQG
Sbjct: 301 RYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQG 360
Query: 298 QHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGV 357
QHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGV
Sbjct: 361 QHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGV 420
Query: 358 TPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRG 417
TPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRG
Sbjct: 421 TPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRG 480
Query: 418 SFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCREC 477
SFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCREC
Sbjct: 481 SFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCREC 540
Query: 478 GLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETG 537
GLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETG
Sbjct: 541 GLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETG 600
Query: 538 CQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 576
CQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 601 CQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 639
>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
Length = 604
Score = 1047 bits (2708), Expect = 0.0
Identities = 522/609 (85%), Positives = 533/609 (87%), Gaps = 38/609 (6%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITA------LLE--------L 226
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT +L+ L
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 227 TELLASHNNYARYRRTWAGCAGF---RLPVLGVHLKDLVSLHEAQP-------------- 269
+ N+ +R+ + R VL + LH+ Q
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 270 --DRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE 327
RL D HL + +ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE
Sbjct: 301 AISRLKDSHAHLSPDST-----KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE 355
Query: 328 LSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRG 387
LSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRG
Sbjct: 356 LSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRG 415
Query: 388 TISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFH 447
TISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFH
Sbjct: 416 TISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFH 475
Query: 448 EVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPG 507
EVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPG
Sbjct: 476 EVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPG 535
Query: 508 APVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPP 567
APVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPP
Sbjct: 536 APVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPP 595
Query: 568 STASSKLDS 576
STASSKLDS
Sbjct: 596 STASSKLDS 604
>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
sapiens]
Length = 581
Score = 1002 bits (2591), Expect = 0.0
Identities = 502/584 (85%), Positives = 514/584 (88%), Gaps = 11/584 (1%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITALLELTELLASHNNYARYR 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT + +L R
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGS---VRGC 237
Query: 241 RTWAGCAGFRLPVLG-VHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQ- 298
G G V V + L Q ++ D +H+ + + L+A+ G
Sbjct: 238 PALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGL 297
Query: 299 -HPPCSANEDL-LHL----LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVE 352
H S +D HL LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVE
Sbjct: 298 CHSAISRLKDSHAHLSPDSTKLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVE 357
Query: 353 WAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPP 412
WAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPP
Sbjct: 358 WAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPP 417
Query: 413 RQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGY 472
RQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGY
Sbjct: 418 RQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGY 477
Query: 473 RCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSL 532
RCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSL
Sbjct: 478 RCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSL 537
Query: 533 EPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 576
EPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 538 EPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 581
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 758 bits (1957), Expect = 0.0
Identities = 355/355 (100%), Positives = 355/355 (100%)
Query: 222 ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK 281
ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK
Sbjct: 319 ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK 378
Query: 282 LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP 341
LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP
Sbjct: 379 LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP 438
Query: 342 PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 401
PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF
Sbjct: 439 PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 498
Query: 402 PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS 461
PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS
Sbjct: 499 PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS 558
Query: 462 GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG 521
GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG
Sbjct: 559 GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG 618
Query: 522 SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 576
SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 619 SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 673
Score = 454 bits (1168), Expect = e-127
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 758 bits (1957), Expect = 0.0
Identities = 355/355 (100%), Positives = 355/355 (100%)
Query: 222 ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK 281
ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK
Sbjct: 305 ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPK 364
Query: 282 LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP 341
LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP
Sbjct: 365 LNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLP 424
Query: 342 PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 401
PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF
Sbjct: 425 PSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 484
Query: 402 PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS 461
PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS
Sbjct: 485 PFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCS 544
Query: 462 GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG 521
GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG
Sbjct: 545 GFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCG 604
Query: 522 SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 576
SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 605 SEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 659
Score = 414 bits (1065), Expect = e-116
Identities = 207/221 (93%), Positives = 207/221 (93%), Gaps = 14/221 (6%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 207
>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
Length = 484
Score = 573 bits (1477), Expect = e-163
Identities = 264/265 (99%), Positives = 265/265 (100%)
Query: 312 LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 371
+TLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE
Sbjct: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 279
Query: 372 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 431
QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA
Sbjct: 280 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 339
Query: 432 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 491
SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV
Sbjct: 340 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 399
Query: 492 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 551
ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH
Sbjct: 400 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 459
Query: 552 PSWETDTVPCPVMDPPSTASSKLDS 576
PSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 460 PSWETDTVPCPVMDPPSTASSKLDS 484
Score = 457 bits (1177), Expect = e-129
Identities = 229/243 (94%), Positives = 231/243 (95%), Gaps = 2/243 (0%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITALLEL--TELLASHNNYAR 238
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT L+L TE +YAR
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLSLDLFYTEDEIYELSYAR 240
Query: 239 YRR 241
R
Sbjct: 241 EPR 243
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 335 bits (858), Expect = 9e-92
Identities = 160/281 (56%), Positives = 208/281 (74%), Gaps = 5/281 (1%)
Query: 225 ELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNN 284
E+TELL+S NY YRR + C F++P+LGVHLKDL+SL+EA PD L DG++++ KL
Sbjct: 326 EMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLA 385
Query: 285 LYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSP 344
LY + ELV LQ PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++ P +P
Sbjct: 386 LYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTP 445
Query: 345 FNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFA 404
P+VV+WA GV+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +FPF+
Sbjct: 446 SKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFS 505
Query: 405 CHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFL 464
+ + G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFL
Sbjct: 506 FCVM---DKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFL 562
Query: 465 WGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 505
WGV KQGYRC++CG+ CHK C+D V ECKKR AK P
Sbjct: 563 WGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAP 601
Score = 125 bits (315), Expect = 8e-29
Identities = 70/188 (37%), Positives = 107/188 (56%), Gaps = 1/188 (0%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAIT 221
F+SF+ I+
Sbjct: 218 FKSFRRIS 225
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 277 bits (709), Expect = 2e-74
Identities = 143/281 (50%), Positives = 181/281 (64%), Gaps = 40/281 (14%)
Query: 225 ELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNN 284
E+TELL+S NY YRR + C F++P+LGVHLKDL+SL+EA PD L DG++++ KL
Sbjct: 326 EMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLA 385
Query: 285 LYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSP 344
LY + ELV LQ PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++
Sbjct: 386 LYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRA----- 440
Query: 345 FNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFA 404
SVFKNYD + G ISQE+FE+++ +FPF+
Sbjct: 441 ------------------------------PSVFKNYDHDQDGYISQEEFEKIAASFPFS 470
Query: 405 CHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFL 464
+ + G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFL
Sbjct: 471 FCVMD---KDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFL 527
Query: 465 WGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 505
WGV KQGYRC++CG+ CHK C+D V ECKKR AK P
Sbjct: 528 WGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAP 566
Score = 125 bits (315), Expect = 8e-29
Identities = 70/188 (37%), Positives = 107/188 (56%), Gaps = 1/188 (0%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAIT 221
F+SF+ I+
Sbjct: 218 FKSFRRIS 225
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 276 bits (706), Expect = 4e-74
Identities = 137/293 (46%), Positives = 195/293 (66%), Gaps = 9/293 (3%)
Query: 225 ELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNN 284
E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL+++H PD + ++++ K++
Sbjct: 273 EMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQ 332
Query: 285 LYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSP 344
L + L ELV+LQ N DL++LLTLSLDL++TED+IY+LS EPR KS P SP
Sbjct: 333 LSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSP 392
Query: 345 F--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 401
N P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NF
Sbjct: 393 TTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANF 452
Query: 402 PFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSC 460
PF + G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C
Sbjct: 453 PF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHC 511
Query: 461 SGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 509
+GFLWG+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 512 AGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
Score = 102 bits (254), Expect = 1e-21
Identities = 62/163 (38%), Positives = 88/163 (53%), Gaps = 3/163 (1%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRIS 172
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 276 bits (706), Expect = 4e-74
Identities = 137/293 (46%), Positives = 195/293 (66%), Gaps = 9/293 (3%)
Query: 225 ELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNN 284
E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL+++H PD + ++++ K++
Sbjct: 273 EMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQ 332
Query: 285 LYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSP 344
L + L ELV+LQ N DL++LLTLSLDL++TED+IY+LS EPR KS P SP
Sbjct: 333 LSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSP 392
Query: 345 F--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 401
N P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NF
Sbjct: 393 TTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANF 452
Query: 402 PFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSC 460
PF + G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C
Sbjct: 453 PF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHC 511
Query: 461 SGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 509
+GFLWG+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 512 AGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
Score = 102 bits (254), Expect = 1e-21
Identities = 62/163 (38%), Positives = 88/163 (53%), Gaps = 3/163 (1%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRIS 172
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 272 bits (696), Expect = 5e-73
Identities = 137/293 (46%), Positives = 195/293 (66%), Gaps = 10/293 (3%)
Query: 225 ELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNN 284
E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL+++H PD + ++++ K++
Sbjct: 273 EMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQ 332
Query: 285 LYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSP 344
L + L ELV+LQ N DL++LLTLSLDL++TED+IY+LS EPR KS P SP
Sbjct: 333 LSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKS-PTSP 391
Query: 345 F--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 401
N P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NF
Sbjct: 392 TTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANF 451
Query: 402 PFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSC 460
PF + G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C
Sbjct: 452 PF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHC 510
Query: 461 SGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 509
+GFLWG+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 511 AGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 563
Score = 102 bits (254), Expect = 1e-21
Identities = 62/163 (38%), Positives = 88/163 (53%), Gaps = 3/163 (1%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRIS 172
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 239 bits (610), Expect = 5e-63
Identities = 127/294 (43%), Positives = 173/294 (58%), Gaps = 11/294 (3%)
Query: 226 LTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHL--PKLN 283
LTEL+ + NY YRR A C GFR P+LGVHLKDLV+L A PD L R L K+
Sbjct: 276 LTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335
Query: 284 NLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPS 343
L+ L+EL + PP AN DLL LLT+SLD + TEDE+Y+LS REPR KS P S
Sbjct: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS-KSSPTS 394
Query: 344 PFNA------PLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 397
P + P++ EW PK D+ + H+E++VESVF+N+D +G G ISQE+F+ +
Sbjct: 395 PTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQII 454
Query: 398 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFC 457
GNFP+ + G SREE+ Y LR+S++ + F+H F E +P C
Sbjct: 455 RGNFPYLS-AFGDLDQNQDGCISREEMVSYFLRSSSVLGGR-MGFVHNFQESNSLRPVAC 512
Query: 458 DSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVP 511
C + G+ KQG +CR CG+ CHK C+D++ VEC++R + G +P P
Sbjct: 513 RHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP 566
Score = 125 bits (313), Expect = 1e-28
Identities = 69/163 (42%), Positives = 97/163 (59%), Gaps = 2/163 (1%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID-IDSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF 217
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSF 170
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 239 bits (610), Expect = 5e-63
Identities = 127/294 (43%), Positives = 173/294 (58%), Gaps = 11/294 (3%)
Query: 226 LTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHL--PKLN 283
LTEL+ + NY YRR A C GFR P+LGVHLKDLV+L A PD L R L K+
Sbjct: 276 LTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335
Query: 284 NLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPS 343
L+ L+EL + PP AN DLL LLT+SLD + TEDE+Y+LS REPR KS P S
Sbjct: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS-KSSPTS 394
Query: 344 PFNA------PLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 397
P + P++ EW PK D+ + H+E++VESVF+N+D +G G ISQE+F+ +
Sbjct: 395 PTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQII 454
Query: 398 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFC 457
GNFP+ + G SREE+ Y LR+S++ + F+H F E +P C
Sbjct: 455 RGNFPYLS-AFGDLDQNQDGCISREEMVSYFLRSSSVLGGR-MGFVHNFQESNSLRPVAC 512
Query: 458 DSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVP 511
C + G+ KQG +CR CG+ CHK C+D++ VEC++R + G +P P
Sbjct: 513 RHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP 566
Score = 125 bits (313), Expect = 1e-28
Identities = 69/163 (42%), Positives = 97/163 (59%), Gaps = 2/163 (1%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID-IDSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF 217
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSF 170
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 239 bits (610), Expect = 5e-63
Identities = 127/294 (43%), Positives = 173/294 (58%), Gaps = 11/294 (3%)
Query: 226 LTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHL--PKLN 283
LTEL+ + NY YRR A C GFR P+LGVHLKDLV+L A PD L R L K+
Sbjct: 276 LTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335
Query: 284 NLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPS 343
L+ L+EL + PP AN DLL LLT+SLD + TEDE+Y+LS REPR KS P S
Sbjct: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS-KSSPTS 394
Query: 344 PFNA------PLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 397
P + P++ EW PK D+ + H+E++VESVF+N+D +G G ISQE+F+ +
Sbjct: 395 PTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQII 454
Query: 398 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFC 457
GNFP+ + G SREE+ Y LR+S++ + F+H F E +P C
Sbjct: 455 RGNFPYLS-AFGDLDQNQDGCISREEMVSYFLRSSSVLGGR-MGFVHNFQESNSLRPVAC 512
Query: 458 DSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVP 511
C + G+ KQG +CR CG+ CHK C+D++ VEC++R + G +P P
Sbjct: 513 RHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP 566
Score = 125 bits (313), Expect = 1e-28
Identities = 69/163 (42%), Positives = 97/163 (59%), Gaps = 2/163 (1%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID-IDSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF 217
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSF 170
>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
Length = 1591
Score = 70.1 bits (170), Expect = 5e-12
Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 416 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 473
R S EEL ++ + + A+ + H F T PT+C C G LWG+ +QG R
Sbjct: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
Query: 474 CRECGLCCHKHCRDQVKVECKKRPGAK 500
C ECG+ CH+ C+D + +C +R K
Sbjct: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 69.3 bits (168), Expect = 9e-12
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 416 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 473
R S + EEL ++ + + A+ + H F T PT+C C G LWG+ +QG +
Sbjct: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
Query: 474 CRECGLCCHKHCRDQVKVECKKRPGAK 500
C ECG+ CH+ C+D + +C +R K
Sbjct: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
>gi|122937247 unc-13 homolog A [Homo sapiens]
Length = 1791
Score = 68.9 bits (167), Expect = 1e-11
Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 418 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 475
+ + EEL ++ + + A+ + H F T PT+C C G LWG+ +QG RC
Sbjct: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
Query: 476 ECGLCCHKHCRDQVKVECKKRPGAK 500
ECG+ CH+ C+D + +C +R K
Sbjct: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 66.6 bits (161), Expect = 6e-11
Identities = 43/131 (32%), Positives = 60/131 (45%), Gaps = 14/131 (10%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC---KKRPGAK 500
HT + +++ PTFCD C LWG+ +QG +C CGL HK C ++ C +KR +
Sbjct: 155 HTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSN 214
Query: 501 GDAGPPGAPVPSTPAP-HASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTV 559
PG VP P + + SEE+H + EP +W S P W V
Sbjct: 215 VSLPGPGLSVPRPLQPEYVALPSEESHVHQ---EPSKRIP---SW----SGRPIWMEKMV 264
Query: 560 PCPVMDPPSTA 570
C V P + A
Sbjct: 265 MCRVKVPHTFA 275
Score = 51.2 bits (121), Expect = 3e-06
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
HTF ++ +PT C C L G+ +QG +C++C CHK C +V +C
Sbjct: 272 HTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDC 321
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 63.2 bits (152), Expect = 6e-10
Identities = 24/50 (48%), Positives = 31/50 (62%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
H F F +PTFC C F+WG+ KQGY+CR+C HK C D+V +C
Sbjct: 160 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 209
Score = 53.5 bits (127), Expect = 5e-07
Identities = 19/50 (38%), Positives = 28/50 (56%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
H F ++ PTFC+ C LWG+ +QG +C CG+ H C+ +V C
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 281
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 62.8 bits (151), Expect = 8e-10
Identities = 36/96 (37%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 410 PPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTK 469
PPP +G S R G L + + K H F F++PTFC C+ F+WG K
Sbjct: 8 PPPSEGEESTVRFARKGALRQKNVHEVKN-----HKFTARFFKQPTFCSHCTDFIWGFGK 62
Query: 470 QGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 505
QG++C+ C HK C + V C PGA D GP
Sbjct: 63 QGFQCQVCCFVVHKRCHEFVTFSC---PGA--DKGP 93
Score = 47.0 bits (110), Expect = 5e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 62.8 bits (151), Expect = 8e-10
Identities = 36/96 (37%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 410 PPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTK 469
PPP +G S R G L + + K H F F++PTFC C+ F+WG K
Sbjct: 8 PPPSEGEESTVRFARKGALRQKNVHEVKN-----HKFTARFFKQPTFCSHCTDFIWGFGK 62
Query: 470 QGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 505
QG++C+ C HK C + V C PGA D GP
Sbjct: 63 QGFQCQVCCFVVHKRCHEFVTFSC---PGA--DKGP 93
Score = 47.0 bits (110), Expect = 5e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 62.0 bits (149), Expect = 1e-09
Identities = 23/50 (46%), Positives = 30/50 (60%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
H F F +PTFC C F+WG+ KQGY+CR+C HK C D++ C
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 208
Score = 59.3 bits (142), Expect = 9e-09
Identities = 22/50 (44%), Positives = 29/50 (58%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
H F + PTFCD C LWG+ KQG +C +CG+ H CR++V C
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 62.0 bits (149), Expect = 1e-09
Identities = 23/50 (46%), Positives = 30/50 (60%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
H F F +PTFC C F+WG+ KQGY+CR+C HK C D++ C
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 208
Score = 59.3 bits (142), Expect = 9e-09
Identities = 22/50 (44%), Positives = 29/50 (58%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
H F + PTFCD C LWG+ KQG +C +CG+ H CR++V C
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 61.2 bits (147), Expect = 2e-09
Identities = 29/82 (35%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Query: 415 GRGSFSREELTGYLLRASAICSKLGLAF--LHTFHEVTFRKPTFCDSCSGFLWGVTKQGY 472
G+ S + LT + RA+ ++ + +H F TFR P +C+ C+ F+WG+ QG
Sbjct: 175 GQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGV 234
Query: 473 RCRECGLCCHKHCRDQVKVECK 494
+C +CGL HK C V +CK
Sbjct: 235 KCADCGLNVHKQCSKMVPNDCK 256
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 59.7 bits (143), Expect = 7e-09
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 494
H F TFR P +C+ C+ F+WG+ QG RC +CGL HK C V +C+
Sbjct: 215 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQ 265
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 59.7 bits (143), Expect = 7e-09
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 494
H F TFR P +C+ C+ F+WG+ QG RC +CGL HK C V +C+
Sbjct: 79 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQ 129
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 59.7 bits (143), Expect = 7e-09
Identities = 24/56 (42%), Positives = 33/56 (58%), Gaps = 3/56 (5%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA 499
H F F++PTFC C+ F+WG+ KQG +C+ C H+ C + V EC PGA
Sbjct: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFEC---PGA 88
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/50 (36%), Positives = 25/50 (50%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
H F ++ PTFCD C L+G+ QG +C C + H+ C V C
Sbjct: 101 HKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC 150
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 59.3 bits (142), Expect = 9e-09
Identities = 27/62 (43%), Positives = 35/62 (56%), Gaps = 5/62 (8%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 503
H F F++PTFC C+ F+WG KQG++C+ C HK C + V C PGA D
Sbjct: 37 HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC---PGA--DK 91
Query: 504 GP 505
GP
Sbjct: 92 GP 93
Score = 47.4 bits (111), Expect = 4e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 444 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLC 151
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 57.0 bits (136), Expect = 5e-08
Identities = 21/45 (46%), Positives = 29/45 (64%)
Query: 450 TFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 494
TFR P +C+ C+ F+WG+ QG +C +CGL HK C V +CK
Sbjct: 186 TFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCK 230
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,292,664
Number of Sequences: 37866
Number of extensions: 1536874
Number of successful extensions: 11888
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 76
Number of HSP's that attempted gapping in prelim test: 10546
Number of HSP's gapped (non-prelim): 1414
length of query: 576
length of database: 18,247,518
effective HSP length: 108
effective length of query: 468
effective length of database: 14,157,990
effective search space: 6625939320
effective search space used: 6625939320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.