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Search of human proteins with 226246584
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
(484 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 1020 0.0
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 573 e-163
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 573 e-163
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 573 e-163
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 573 e-163
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 573 e-163
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi... 570 e-163
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 237 2e-62
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 199 5e-51
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 199 5e-51
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 195 7e-50
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 179 4e-45
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 161 1e-39
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 161 1e-39
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 161 1e-39
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens] 70 4e-12
gi|122937514 unc-13 homolog C [Homo sapiens] 69 7e-12
gi|122937247 unc-13 homolog A [Homo sapiens] 69 1e-11
gi|5031689 protein kinase D3 [Homo sapiens] 67 5e-11
gi|5453976 protein kinase C, theta [Homo sapiens] 63 5e-10
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 63 7e-10
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 63 7e-10
gi|47157325 protein kinase C, delta [Homo sapiens] 62 1e-09
gi|31377782 protein kinase C, delta [Homo sapiens] 62 1e-09
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 61 2e-09
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 60 6e-09
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 60 6e-09
gi|13384594 protein kinase C, gamma [Homo sapiens] 60 6e-09
gi|4506067 protein kinase C, alpha [Homo sapiens] 59 8e-09
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 57 4e-08
>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
Length = 484
Score = 1020 bits (2638), Expect = 0.0
Identities = 484/484 (100%), Positives = 484/484 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLSLDLFYTEDEIYELSYAR 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLSLDLFYTEDEIYELSYAR
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLSLDLFYTEDEIYELSYAR 240
Query: 241 EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE 300
EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE
Sbjct: 241 EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE 300
Query: 301 DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR 360
DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR
Sbjct: 301 DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR 360
Query: 361 KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS 420
KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS
Sbjct: 361 KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS 420
Query: 421 TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS 480
TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS
Sbjct: 421 TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS 480
Query: 481 KLDS 484
KLDS
Sbjct: 481 KLDS 484
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 573 bits (1477), Expect = e-163
Identities = 264/265 (99%), Positives = 265/265 (100%)
Query: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 279
+TLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE
Sbjct: 409 LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 468
Query: 280 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 339
QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA
Sbjct: 469 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 528
Query: 340 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 399
SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV
Sbjct: 529 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 588
Query: 400 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 459
ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH
Sbjct: 589 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 648
Query: 460 PSWETDTVPCPVMDPPSTASSKLDS 484
PSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 649 PSWETDTVPCPVMDPPSTASSKLDS 673
Score = 454 bits (1168), Expect = e-128
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 573 bits (1477), Expect = e-163
Identities = 264/265 (99%), Positives = 265/265 (100%)
Query: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 279
+TLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE
Sbjct: 312 LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 371
Query: 280 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 339
QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA
Sbjct: 372 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 431
Query: 340 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 399
SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV
Sbjct: 432 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 491
Query: 400 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 459
ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH
Sbjct: 492 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 551
Query: 460 PSWETDTVPCPVMDPPSTASSKLDS 484
PSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 552 PSWETDTVPCPVMDPPSTASSKLDS 576
Score = 457 bits (1177), Expect = e-129
Identities = 229/243 (94%), Positives = 231/243 (95%), Gaps = 2/243 (0%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLSLDLFYTEDEIYELSYAR 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT L+L TE +YAR
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITALLEL--TELLASHNNYAR 238
Query: 241 EPR 243
R
Sbjct: 239 YRR 241
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 573 bits (1477), Expect = e-163
Identities = 264/265 (99%), Positives = 265/265 (100%)
Query: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 279
+TLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE
Sbjct: 375 LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 434
Query: 280 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 339
QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA
Sbjct: 435 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 494
Query: 340 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 399
SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV
Sbjct: 495 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 554
Query: 400 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 459
ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH
Sbjct: 555 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 614
Query: 460 PSWETDTVPCPVMDPPSTASSKLDS 484
PSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 615 PSWETDTVPCPVMDPPSTASSKLDS 639
Score = 454 bits (1169), Expect = e-128
Identities = 221/222 (99%), Positives = 222/222 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITL 222
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT+
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITV 222
>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
Length = 604
Score = 573 bits (1477), Expect = e-163
Identities = 264/265 (99%), Positives = 265/265 (100%)
Query: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 279
+TLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE
Sbjct: 340 LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 399
Query: 280 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 339
QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA
Sbjct: 400 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 459
Query: 340 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 399
SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV
Sbjct: 460 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 519
Query: 400 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 459
ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH
Sbjct: 520 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 579
Query: 460 PSWETDTVPCPVMDPPSTASSKLDS 484
PSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 580 PSWETDTVPCPVMDPPSTASSKLDS 604
Score = 454 bits (1168), Expect = e-128
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 573 bits (1477), Expect = e-163
Identities = 264/265 (99%), Positives = 265/265 (100%)
Query: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 279
+TLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE
Sbjct: 395 LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 454
Query: 280 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 339
QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA
Sbjct: 455 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 514
Query: 340 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 399
SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV
Sbjct: 515 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 574
Query: 400 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 459
ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH
Sbjct: 575 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 634
Query: 460 PSWETDTVPCPVMDPPSTASSKLDS 484
PSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 635 PSWETDTVPCPVMDPPSTASSKLDS 659
Score = 414 bits (1065), Expect = e-116
Identities = 207/221 (93%), Positives = 207/221 (93%), Gaps = 14/221 (6%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 207
>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
sapiens]
Length = 581
Score = 570 bits (1470), Expect = e-163
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 222 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 281
LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL
Sbjct: 319 LSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQL 378
Query: 282 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 341
VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA
Sbjct: 379 VESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASA 438
Query: 342 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC
Sbjct: 439 ICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 498
Query: 402 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 461
KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS
Sbjct: 499 KKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPS 558
Query: 462 WETDTVPCPVMDPPSTASSKLDS 484
WETDTVPCPVMDPPSTASSKLDS
Sbjct: 559 WETDTVPCPVMDPPSTASSKLDS 581
Score = 454 bits (1168), Expect = e-128
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 237 bits (604), Expect = 2e-62
Identities = 118/225 (52%), Positives = 158/225 (70%), Gaps = 8/225 (3%)
Query: 192 KVSLLFDHL-ETGELAQHLTYLEFRS--FQAITLSLDLFYTEDEIYELSYAREPRCPKSL 248
K+ L++H+ E +L + LE +TLSLDL+YTEDEIYELSYAREPR ++
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAP 441
Query: 249 PPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGN 308
P +P P+VV+WA GV+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +
Sbjct: 442 PLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAAS 501
Query: 309 FPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSC 368
FPF+ + + G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C
Sbjct: 502 FPFSFCVM---DKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNC 558
Query: 369 SGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 413
+GFLWGV KQGYRC++CG+ CHK C+D V ECKKR AK P
Sbjct: 559 AGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAP 601
Score = 127 bits (319), Expect = 2e-29
Identities = 71/190 (37%), Positives = 108/190 (56%), Gaps = 1/190 (0%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAITLS 223
F+SF+ I+ S
Sbjct: 218 FKSFRRISFS 227
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 199 bits (506), Expect = 5e-51
Identities = 104/237 (43%), Positives = 145/237 (61%), Gaps = 9/237 (3%)
Query: 189 KKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLSLDLFYTEDEIYELSYAREPRCPKSL 248
K ++S+ L + + A H +TLSLDL++TED+IY+LS EPR KS
Sbjct: 329 KMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQ 388
Query: 249 PPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 305
P SP N P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE +
Sbjct: 389 PTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESI 448
Query: 306 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTF 364
+ NFPF + G S++E+ Y LRA S + K+G F+H F E+T+ KPTF
Sbjct: 449 AANFPFL-DSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTF 507
Query: 365 CDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 417
C+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 508 CEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
Score = 102 bits (255), Expect = 6e-22
Identities = 62/165 (37%), Positives = 89/165 (53%), Gaps = 3/165 (1%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLS 223
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ +
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFT 174
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 199 bits (506), Expect = 5e-51
Identities = 104/237 (43%), Positives = 145/237 (61%), Gaps = 9/237 (3%)
Query: 189 KKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLSLDLFYTEDEIYELSYAREPRCPKSL 248
K ++S+ L + + A H +TLSLDL++TED+IY+LS EPR KS
Sbjct: 329 KMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQ 388
Query: 249 PPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 305
P SP N P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE +
Sbjct: 389 PTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESI 448
Query: 306 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTF 364
+ NFPF + G S++E+ Y LRA S + K+G F+H F E+T+ KPTF
Sbjct: 449 AANFPFL-DSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTF 507
Query: 365 CDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 417
C+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 508 CEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
Score = 102 bits (255), Expect = 6e-22
Identities = 62/165 (37%), Positives = 89/165 (53%), Gaps = 3/165 (1%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLS 223
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ +
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFT 174
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 195 bits (496), Expect = 7e-50
Identities = 104/237 (43%), Positives = 145/237 (61%), Gaps = 10/237 (4%)
Query: 189 KKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLSLDLFYTEDEIYELSYAREPRCPKSL 248
K ++S+ L + + A H +TLSLDL++TED+IY+LS EPR KS
Sbjct: 329 KMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKS- 387
Query: 249 PPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 305
P SP N P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE +
Sbjct: 388 PTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESI 447
Query: 306 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTF 364
+ NFPF + G S++E+ Y LRA S + K+G F+H F E+T+ KPTF
Sbjct: 448 AANFPFL-DSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTF 506
Query: 365 CDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 417
C+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 507 CEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 563
Score = 102 bits (255), Expect = 6e-22
Identities = 62/165 (37%), Positives = 89/165 (53%), Gaps = 3/165 (1%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLS 223
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ +
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFT 174
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 179 bits (455), Expect = 4e-45
Identities = 101/225 (44%), Positives = 131/225 (58%), Gaps = 43/225 (19%)
Query: 192 KVSLLFDHL-ETGELAQHLTYLEFRS--FQAITLSLDLFYTEDEIYELSYAREPRCPKSL 248
K+ L++H+ E +L + LE +TLSLDL+YTEDEIYELSYAREPR ++
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRA- 440
Query: 249 PPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGN 308
SVFKNYD + G ISQE+FE+++ +
Sbjct: 441 ----------------------------------PSVFKNYDHDQDGYISQEEFEKIAAS 466
Query: 309 FPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSC 368
FPF+ + + G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C
Sbjct: 467 FPFSFCVMD---KDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNC 523
Query: 369 SGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 413
+GFLWGV KQGYRC++CG+ CHK C+D V ECKKR AK P
Sbjct: 524 AGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAP 566
Score = 127 bits (319), Expect = 2e-29
Identities = 71/190 (37%), Positives = 108/190 (56%), Gaps = 1/190 (0%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAITLS 223
F+SF+ I+ S
Sbjct: 218 FKSFRRISFS 227
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 161 bits (408), Expect = 1e-39
Identities = 82/206 (39%), Positives = 121/206 (58%), Gaps = 9/206 (4%)
Query: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVT 273
+T+SLD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+
Sbjct: 364 LTVSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQAL 422
Query: 274 LGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELT 333
+ H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+
Sbjct: 423 VVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLS-AFGDLDQNQDGCISREEMV 481
Query: 334 GYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHC 393
Y LR+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C
Sbjct: 482 SYFLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
Query: 394 RDQVKVECKKRPGAKGDAGPPGAPVP 419
+D++ VEC++R + G +P P
Sbjct: 541 KDRLSVECRRRAQSVSLEGSAPSPSP 566
Score = 125 bits (313), Expect = 1e-28
Identities = 69/163 (42%), Positives = 97/163 (59%), Gaps = 2/163 (1%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID-IDSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF 217
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSF 170
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 161 bits (408), Expect = 1e-39
Identities = 82/206 (39%), Positives = 121/206 (58%), Gaps = 9/206 (4%)
Query: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVT 273
+T+SLD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+
Sbjct: 364 LTVSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQAL 422
Query: 274 LGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELT 333
+ H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+
Sbjct: 423 VVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLS-AFGDLDQNQDGCISREEMV 481
Query: 334 GYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHC 393
Y LR+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C
Sbjct: 482 SYFLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
Query: 394 RDQVKVECKKRPGAKGDAGPPGAPVP 419
+D++ VEC++R + G +P P
Sbjct: 541 KDRLSVECRRRAQSVSLEGSAPSPSP 566
Score = 125 bits (313), Expect = 1e-28
Identities = 69/163 (42%), Positives = 97/163 (59%), Gaps = 2/163 (1%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID-IDSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF 217
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSF 170
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 161 bits (408), Expect = 1e-39
Identities = 82/206 (39%), Positives = 121/206 (58%), Gaps = 9/206 (4%)
Query: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA------PLVVEWAPGVTPKPDRVT 273
+T+SLD + TEDE+Y+LS REPR KS P SP + P++ EW PK D+
Sbjct: 364 LTVSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQAL 422
Query: 274 LGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELT 333
+ H+E++VESVF+N+D +G G ISQE+F+ + GNFP+ + G SREE+
Sbjct: 423 VVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLS-AFGDLDQNQDGCISREEMV 481
Query: 334 GYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHC 393
Y LR+S++ + F+H F E +P C C + G+ KQG +CR CG+ CHK C
Sbjct: 482 SYFLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC 540
Query: 394 RDQVKVECKKRPGAKGDAGPPGAPVP 419
+D++ VEC++R + G +P P
Sbjct: 541 KDRLSVECRRRAQSVSLEGSAPSPSP 566
Score = 125 bits (313), Expect = 1e-28
Identities = 69/163 (42%), Positives = 97/163 (59%), Gaps = 2/163 (1%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID-IDSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSF 217
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSF 170
>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
Length = 1591
Score = 70.1 bits (170), Expect = 4e-12
Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 324 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 381
R S EEL ++ + + A+ + H F T PT+C C G LWG+ +QG R
Sbjct: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
Query: 382 CRECGLCCHKHCRDQVKVECKKRPGAK 408
C ECG+ CH+ C+D + +C +R K
Sbjct: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 69.3 bits (168), Expect = 7e-12
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 324 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 381
R S + EEL ++ + + A+ + H F T PT+C C G LWG+ +QG +
Sbjct: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
Query: 382 CRECGLCCHKHCRDQVKVECKKRPGAK 408
C ECG+ CH+ C+D + +C +R K
Sbjct: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
>gi|122937247 unc-13 homolog A [Homo sapiens]
Length = 1791
Score = 68.9 bits (167), Expect = 1e-11
Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 326 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 383
+ + EEL ++ + + A+ + H F T PT+C C G LWG+ +QG RC
Sbjct: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
Query: 384 ECGLCCHKHCRDQVKVECKKRPGAK 408
ECG+ CH+ C+D + +C +R K
Sbjct: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 66.6 bits (161), Expect = 5e-11
Identities = 43/131 (32%), Positives = 60/131 (45%), Gaps = 14/131 (10%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC---KKRPGAK 408
HT + +++ PTFCD C LWG+ +QG +C CGL HK C ++ C +KR +
Sbjct: 155 HTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSN 214
Query: 409 GDAGPPGAPVPSTPAP-HASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTV 467
PG VP P + + SEE+H + EP +W S P W V
Sbjct: 215 VSLPGPGLSVPRPLQPEYVALPSEESHVHQ---EPSKRIP---SW----SGRPIWMEKMV 264
Query: 468 PCPVMDPPSTA 478
C V P + A
Sbjct: 265 MCRVKVPHTFA 275
Score = 51.2 bits (121), Expect = 2e-06
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
HTF ++ +PT C C L G+ +QG +C++C CHK C +V +C
Sbjct: 272 HTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDC 321
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 63.2 bits (152), Expect = 5e-10
Identities = 24/50 (48%), Positives = 31/50 (62%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
H F F +PTFC C F+WG+ KQGY+CR+C HK C D+V +C
Sbjct: 160 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 209
Score = 53.5 bits (127), Expect = 4e-07
Identities = 19/50 (38%), Positives = 28/50 (56%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
H F ++ PTFC+ C LWG+ +QG +C CG+ H C+ +V C
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 281
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 62.8 bits (151), Expect = 7e-10
Identities = 36/96 (37%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 318 PPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTK 377
PPP +G S R G L + + K H F F++PTFC C+ F+WG K
Sbjct: 8 PPPSEGEESTVRFARKGALRQKNVHEVKN-----HKFTARFFKQPTFCSHCTDFIWGFGK 62
Query: 378 QGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 413
QG++C+ C HK C + V C PGA D GP
Sbjct: 63 QGFQCQVCCFVVHKRCHEFVTFSC---PGA--DKGP 93
Score = 47.0 bits (110), Expect = 4e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 62.8 bits (151), Expect = 7e-10
Identities = 36/96 (37%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 318 PPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTK 377
PPP +G S R G L + + K H F F++PTFC C+ F+WG K
Sbjct: 8 PPPSEGEESTVRFARKGALRQKNVHEVKN-----HKFTARFFKQPTFCSHCTDFIWGFGK 62
Query: 378 QGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 413
QG++C+ C HK C + V C PGA D GP
Sbjct: 63 QGFQCQVCCFVVHKRCHEFVTFSC---PGA--DKGP 93
Score = 47.0 bits (110), Expect = 4e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 62.0 bits (149), Expect = 1e-09
Identities = 23/50 (46%), Positives = 30/50 (60%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
H F F +PTFC C F+WG+ KQGY+CR+C HK C D++ C
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 208
Score = 59.3 bits (142), Expect = 8e-09
Identities = 22/50 (44%), Positives = 29/50 (58%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
H F + PTFCD C LWG+ KQG +C +CG+ H CR++V C
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 62.0 bits (149), Expect = 1e-09
Identities = 23/50 (46%), Positives = 30/50 (60%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
H F F +PTFC C F+WG+ KQGY+CR+C HK C D++ C
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 208
Score = 59.3 bits (142), Expect = 8e-09
Identities = 22/50 (44%), Positives = 29/50 (58%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
H F + PTFCD C LWG+ KQG +C +CG+ H CR++V C
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 61.2 bits (147), Expect = 2e-09
Identities = 29/82 (35%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Query: 323 GRGSFSREELTGYLLRASAICSKLGLAF--LHTFHEVTFRKPTFCDSCSGFLWGVTKQGY 380
G+ S + LT + RA+ ++ + +H F TFR P +C+ C+ F+WG+ QG
Sbjct: 175 GQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGV 234
Query: 381 RCRECGLCCHKHCRDQVKVECK 402
+C +CGL HK C V +CK
Sbjct: 235 KCADCGLNVHKQCSKMVPNDCK 256
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 59.7 bits (143), Expect = 6e-09
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 402
H F TFR P +C+ C+ F+WG+ QG RC +CGL HK C V +C+
Sbjct: 215 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQ 265
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 59.7 bits (143), Expect = 6e-09
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 402
H F TFR P +C+ C+ F+WG+ QG RC +CGL HK C V +C+
Sbjct: 79 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQ 129
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 59.7 bits (143), Expect = 6e-09
Identities = 24/56 (42%), Positives = 33/56 (58%), Gaps = 3/56 (5%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA 407
H F F++PTFC C+ F+WG+ KQG +C+ C H+ C + V EC PGA
Sbjct: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFEC---PGA 88
Score = 45.1 bits (105), Expect = 1e-04
Identities = 18/50 (36%), Positives = 25/50 (50%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
H F ++ PTFCD C L+G+ QG +C C + H+ C V C
Sbjct: 101 HKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC 150
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 59.3 bits (142), Expect = 8e-09
Identities = 27/62 (43%), Positives = 35/62 (56%), Gaps = 5/62 (8%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 411
H F F++PTFC C+ F+WG KQG++C+ C HK C + V C PGA D
Sbjct: 37 HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC---PGA--DK 91
Query: 412 GP 413
GP
Sbjct: 92 GP 93
Score = 47.4 bits (111), Expect = 3e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 352 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLC 151
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 57.0 bits (136), Expect = 4e-08
Identities = 21/45 (46%), Positives = 29/45 (64%)
Query: 358 TFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 402
TFR P +C+ C+ F+WG+ QG +C +CGL HK C V +CK
Sbjct: 186 TFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCK 230
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,352,195
Number of Sequences: 37866
Number of extensions: 1342060
Number of successful extensions: 11439
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 84
Number of HSP's that attempted gapping in prelim test: 10073
Number of HSP's gapped (non-prelim): 1446
length of query: 484
length of database: 18,247,518
effective HSP length: 106
effective length of query: 378
effective length of database: 14,233,722
effective search space: 5380346916
effective search space used: 5380346916
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.