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Search of human proteins with 226246579
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
(604 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 1259 0.0
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi... 1199 0.0
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 1047 0.0
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 1017 0.0
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 649 0.0
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 619 e-177
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 573 e-163
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 261 1e-69
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 234 2e-61
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 233 5e-61
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 233 5e-61
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 233 5e-61
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 217 3e-56
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 217 3e-56
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 217 3e-56
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens] 70 6e-12
gi|122937514 unc-13 homolog C [Homo sapiens] 69 1e-11
gi|122937247 unc-13 homolog A [Homo sapiens] 69 1e-11
gi|5031689 protein kinase D3 [Homo sapiens] 67 6e-11
gi|5453976 protein kinase C, theta [Homo sapiens] 63 7e-10
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 63 9e-10
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 63 9e-10
gi|47157325 protein kinase C, delta [Homo sapiens] 62 2e-09
gi|31377782 protein kinase C, delta [Homo sapiens] 62 2e-09
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 61 3e-09
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 60 8e-09
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 60 8e-09
gi|13384594 protein kinase C, gamma [Homo sapiens] 60 8e-09
gi|4506067 protein kinase C, alpha [Homo sapiens] 59 1e-08
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 57 5e-08
>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
Length = 604
Score = 1259 bits (3259), Expect = 0.0
Identities = 604/604 (100%), Positives = 604/604 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 301 AISRLKDSHAHLSPDSTKELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAR 360
AISRLKDSHAHLSPDSTKELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAR
Sbjct: 301 AISRLKDSHAHLSPDSTKELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAR 360
Query: 361 EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE 420
EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE
Sbjct: 361 EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE 420
Query: 421 DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR 480
DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR
Sbjct: 421 DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR 480
Query: 481 KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS 540
KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS
Sbjct: 481 KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS 540
Query: 541 TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS 600
TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS
Sbjct: 541 TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS 600
Query: 601 KLDS 604
KLDS
Sbjct: 601 KLDS 604
>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
sapiens]
Length = 581
Score = 1199 bits (3103), Expect = 0.0
Identities = 581/604 (96%), Positives = 581/604 (96%), Gaps = 23/604 (3%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 301 AISRLKDSHAHLSPDSTKELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAR 360
AISRLKDSHAHLSPDSTK LSLDLFYTEDEIYELSYAR
Sbjct: 301 AISRLKDSHAHLSPDSTK-----------------------LSLDLFYTEDEIYELSYAR 337
Query: 361 EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE 420
EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE
Sbjct: 338 EPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQE 397
Query: 421 DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR 480
DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR
Sbjct: 398 DFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFR 457
Query: 481 KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS 540
KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS
Sbjct: 458 KPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPS 517
Query: 541 TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS 600
TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS
Sbjct: 518 TPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASS 577
Query: 601 KLDS 604
KLDS
Sbjct: 578 KLDS 581
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 1047 bits (2708), Expect = 0.0
Identities = 522/609 (85%), Positives = 533/609 (87%), Gaps = 38/609 (6%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT +L+ L
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITA------LLE--------L 226
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
+ N+ +R+ + R VL + LH+ Q
Sbjct: 227 TELLASHNNYARYRRTWAGCAGF---RLPVLGVHLKDLVSLHEAQP-------------- 269
Query: 301 AISRLKDSHAHLSPDST-----KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE 355
RL D HL + +ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE
Sbjct: 270 --DRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE 327
Query: 356 LSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRG 415
LSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRG
Sbjct: 328 LSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRG 387
Query: 416 TISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFH 475
TISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFH
Sbjct: 388 TISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFH 447
Query: 476 EVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPG 535
EVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPG
Sbjct: 448 EVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPG 507
Query: 536 APVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPP 595
APVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPP
Sbjct: 508 APVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPP 567
Query: 596 STASSKLDS 604
STASSKLDS
Sbjct: 568 STASSKLDS 576
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 1017 bits (2629), Expect = 0.0
Identities = 511/642 (79%), Positives = 533/642 (83%), Gaps = 41/642 (6%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQ +L + F++ + G ++ L
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQ---HLTYLEFRSFQAITVMVLSRPGPLQRAQVL 237
Query: 241 EGSVGLSNSVSRWVQVMVLSR-PGPLQRAQVL---DKFIHVA-----------QRLHQLQ 285
+ + ++ + + L G L + + D H++ + L
Sbjct: 238 DKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHN 297
Query: 286 NFNTLMAVTGG------------------LCHSAISRLKDSHAHLSPDST-----KELVA 322
N+ G L + RL D HL + +ELVA
Sbjct: 298 NYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVA 357
Query: 323 LQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWA 382
LQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWA
Sbjct: 358 LQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWA 417
Query: 383 PGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQ 442
PGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQ
Sbjct: 418 PGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQ 477
Query: 443 GRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRC 502
GRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRC
Sbjct: 478 GRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRC 537
Query: 503 RECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEP 562
RECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEP
Sbjct: 538 RECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEP 597
Query: 563 ETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 604
ETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 598 ETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS 639
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 649 bits (1674), Expect = 0.0
Identities = 320/323 (99%), Positives = 321/323 (99%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
Query: 301 AISRLKDSHAHLSPDSTKELVAL 323
AISRLKDSHAHLSPDSTK L+ L
Sbjct: 301 AISRLKDSHAHLSPDSTKALLEL 323
Score = 619 bits (1597), Expect = e-177
Identities = 291/306 (95%), Positives = 293/306 (95%), Gaps = 5/306 (1%)
Query: 304 RLKDSHAHLSPDST-----KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY 358
RL D HL + +ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY
Sbjct: 368 RLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY 427
Query: 359 AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS 418
AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS
Sbjct: 428 AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS 487
Query: 419 QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT 478
QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT
Sbjct: 488 QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT 547
Query: 479 FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV 538
FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV
Sbjct: 548 FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV 607
Query: 539 PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA 598
PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA
Sbjct: 608 PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA 667
Query: 599 SSKLDS 604
SSKLDS
Sbjct: 668 SSKLDS 673
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 619 bits (1597), Expect = e-177
Identities = 291/306 (95%), Positives = 293/306 (95%), Gaps = 5/306 (1%)
Query: 304 RLKDSHAHLSPDST-----KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY 358
RL D HL + +ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY
Sbjct: 354 RLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSY 413
Query: 359 AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS 418
AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS
Sbjct: 414 AREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTIS 473
Query: 419 QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT 478
QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT
Sbjct: 474 QEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVT 533
Query: 479 FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV 538
FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV
Sbjct: 534 FRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPV 593
Query: 539 PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA 598
PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA
Sbjct: 594 PSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTA 653
Query: 599 SSKLDS 604
SSKLDS
Sbjct: 654 SSKLDS 659
Score = 609 bits (1571), Expect = e-174
Identities = 306/323 (94%), Positives = 307/323 (95%), Gaps = 14/323 (4%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL---------- 170
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 240
PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
Sbjct: 171 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
Query: 241 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 300
EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
Sbjct: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
Query: 301 AISRLKDSHAHLSPDSTKELVAL 323
AISRLKDSHAHLSPDSTK L+ L
Sbjct: 287 AISRLKDSHAHLSPDSTKALLEL 309
>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
Length = 484
Score = 573 bits (1477), Expect = e-163
Identities = 264/265 (99%), Positives = 265/265 (100%)
Query: 340 LTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 399
+TLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE
Sbjct: 220 ITLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVE 279
Query: 400 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 459
QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA
Sbjct: 280 QLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA 339
Query: 460 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 519
SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV
Sbjct: 340 SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKV 399
Query: 520 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 579
ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH
Sbjct: 400 ECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPH 459
Query: 580 PSWETDTVPCPVMDPPSTASSKLDS 604
PSWETDTVPCPVMDPPSTASSKLDS
Sbjct: 460 PSWETDTVPCPVMDPPSTASSKLDS 484
Score = 454 bits (1168), Expect = e-127
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
Sbjct: 1 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE 60
Query: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
Sbjct: 61 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ 120
Query: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
Sbjct: 121 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL 180
Query: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT
Sbjct: 181 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 261 bits (667), Expect = 1e-69
Identities = 125/215 (58%), Positives = 160/215 (74%), Gaps = 5/215 (2%)
Query: 319 ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLV 378
ELV LQ PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++ P +P P+V
Sbjct: 392 ELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVV 451
Query: 379 VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHP 438
V+WA GV+PKPD T+ +HV+++V+SVFKNYD + G ISQE+FE+++ +FPF+ +
Sbjct: 452 VDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVM-- 509
Query: 439 PPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQ 498
+ G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQ
Sbjct: 510 -DKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQ 568
Query: 499 GYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 533
GYRC++CG+ CHK C+D V ECKKR AK P
Sbjct: 569 GYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAP 601
Score = 234 bits (597), Expect = 2e-61
Identities = 125/287 (43%), Positives = 180/287 (62%), Gaps = 1/287 (0%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 273
F+SF+ I+ D ++Y++ V+ P +E S+ L N +S+WVQ+MVLSRP P RA+V K
Sbjct: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
Query: 274 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKEL 320
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K L
Sbjct: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVL 324
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 234 bits (597), Expect = 2e-61
Identities = 125/287 (43%), Positives = 180/287 (62%), Gaps = 1/287 (0%)
Query: 34 PSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVL 93
PS I++ ++LG L++G S D+L++ CIQSFD+ G+LC + +L ++L MH V+
Sbjct: 39 PSLAHITQFRMMVSLGHLAKGA-SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVI 97
Query: 94 PSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATV 153
SA+L +++T Y+ A L+IC+ VRYW+ + D L + + F V
Sbjct: 98 SSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELV 157
Query: 154 AREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLE 213
+G RL D++ + + KKRKVSLLFDHLE EL++HLTYLE
Sbjct: 158 KAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLE 217
Query: 214 FRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDK 273
F+SF+ I+ D ++Y++ V+ P +E S+ L N +S+WVQ+MVLSRP P RA+V K
Sbjct: 218 FKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIK 277
Query: 274 FIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKEL 320
FI VAQ+LHQLQNFNTLMAV GGLCHS+ISRLK++ +H+ + K L
Sbjct: 278 FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVL 324
Score = 204 bits (518), Expect = 2e-52
Identities = 108/215 (50%), Positives = 133/215 (61%), Gaps = 40/215 (18%)
Query: 319 ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLV 378
ELV LQ PP AN+DL+HLLTLSLDL+YTEDEIYELSYAREPR ++
Sbjct: 392 ELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRA----------- 440
Query: 379 VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHP 438
SVFKNYD + G ISQE+FE+++ +FPF+ +
Sbjct: 441 ------------------------PSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVMD- 475
Query: 439 PPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQ 498
+ G SR+E+T Y +RAS+I SKLGL F H F E T+ KPTFCD+C+GFLWGV KQ
Sbjct: 476 --KDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQ 533
Query: 499 GYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 533
GYRC++CG+ CHK C+D V ECKKR AK P
Sbjct: 534 GYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAP 566
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 233 bits (593), Expect = 5e-61
Identities = 129/279 (46%), Positives = 175/279 (62%), Gaps = 8/279 (2%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 295 GGLCHSAISRLKDSHAHLSPDSTK------ELVALQGQH 327
GGL HS+ISRLK++H+H+SP++ K ELV G +
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNY 286
Score = 180 bits (456), Expect = 4e-45
Identities = 93/228 (40%), Positives = 133/228 (58%), Gaps = 9/228 (3%)
Query: 318 KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA-- 375
+EL + PP AN DLL LLT+SLD + TEDE+Y+LS REPR KS P SP +
Sbjct: 342 EELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTP 400
Query: 376 ----PLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPF 431
P++ EW PK D+ + H+E++VESVF+N+D +G G ISQE+F+ + GNFP+
Sbjct: 401 PPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY 460
Query: 432 ACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGF 491
+ G SREE+ Y LR+S++ + F+H F E +P C C
Sbjct: 461 LS-AFGDLDQNQDGCISREEMVSYFLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKAL 518
Query: 492 LWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVP 539
+ G+ KQG +CR CG+ CHK C+D++ VEC++R + G +P P
Sbjct: 519 ILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP 566
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 233 bits (593), Expect = 5e-61
Identities = 129/279 (46%), Positives = 175/279 (62%), Gaps = 8/279 (2%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 295 GGLCHSAISRLKDSHAHLSPDSTK------ELVALQGQH 327
GGL HS+ISRLK++H+H+SP++ K ELV G +
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNY 286
Score = 180 bits (456), Expect = 4e-45
Identities = 93/228 (40%), Positives = 133/228 (58%), Gaps = 9/228 (3%)
Query: 318 KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA-- 375
+EL + PP AN DLL LLT+SLD + TEDE+Y+LS REPR KS P SP +
Sbjct: 342 EELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTP 400
Query: 376 ----PLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPF 431
P++ EW PK D+ + H+E++VESVF+N+D +G G ISQE+F+ + GNFP+
Sbjct: 401 PPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY 460
Query: 432 ACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGF 491
+ G SREE+ Y LR+S++ + F+H F E +P C C
Sbjct: 461 LS-AFGDLDQNQDGCISREEMVSYFLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKAL 518
Query: 492 LWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVP 539
+ G+ KQG +CR CG+ CHK C+D++ VEC++R + G +P P
Sbjct: 519 ILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP 566
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 233 bits (593), Expect = 5e-61
Identities = 129/279 (46%), Positives = 175/279 (62%), Gaps = 8/279 (2%)
Query: 55 GCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQ 114
GC+ +ELL CI++FD +G + + ++ M L MH W +PS+ LAA+LL YQ++ D
Sbjct: 10 GCTVEELLRGCIEAFDDSGKV-RDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNS 68
Query: 115 ELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPG 174
+++ CHLVRYW+ P +P+L E I A + +EGN L D D +
Sbjct: 69 NSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDI-DSVPTY 127
Query: 175 GPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV 234
+ +P KKRK+SLLFDHLE ELA+HLTYLE+RSF I QD S+V G
Sbjct: 128 KWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCT 187
Query: 235 RGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVT 294
P LE + L NSVS+WVQ+M+LS+P QRA V+ F+HVA++L QLQNFNTLMAV
Sbjct: 188 VDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVV 247
Query: 295 GGLCHSAISRLKDSHAHLSPDSTK------ELVALQGQH 327
GGL HS+ISRLK++H+H+SP++ K ELV G +
Sbjct: 248 GGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNY 286
Score = 180 bits (456), Expect = 4e-45
Identities = 93/228 (40%), Positives = 133/228 (58%), Gaps = 9/228 (3%)
Query: 318 KELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNA-- 375
+EL + PP AN DLL LLT+SLD + TEDE+Y+LS REPR KS P SP +
Sbjct: 342 EELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS-KSSPTSPTSCTP 400
Query: 376 ----PLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPF 431
P++ EW PK D+ + H+E++VESVF+N+D +G G ISQE+F+ + GNFP+
Sbjct: 401 PPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPY 460
Query: 432 ACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGF 491
+ G SREE+ Y LR+S++ + F+H F E +P C C
Sbjct: 461 LS-AFGDLDQNQDGCISREEMVSYFLRSSSVLGGR-MGFVHNFQESNSLRPVACRHCKAL 518
Query: 492 LWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVP 539
+ G+ KQG +CR CG+ CHK C+D++ VEC++R + G +P P
Sbjct: 519 ILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP 566
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 217 bits (552), Expect = 3e-56
Identities = 123/275 (44%), Positives = 170/275 (61%), Gaps = 9/275 (3%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 299 HSAISRLKDSHAHLSPDSTK------ELVALQGQH 327
HS+ISRLK++H+HLS + TK ELV+ G +
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNY 284
Score = 211 bits (538), Expect = 1e-54
Identities = 109/227 (48%), Positives = 147/227 (64%), Gaps = 9/227 (3%)
Query: 319 ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPF--NAP 376
ELV+LQ N DL++LLTLSLDL++TED+IY+LS EPR KS P SP N P
Sbjct: 339 ELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKP 398
Query: 377 LV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHG 435
+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NFPF
Sbjct: 399 VVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFL-DS 457
Query: 436 LHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWG 494
+ G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C+GFLWG
Sbjct: 458 FCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWG 517
Query: 495 VTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 537
+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 518 IIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 217 bits (552), Expect = 3e-56
Identities = 123/275 (44%), Positives = 170/275 (61%), Gaps = 9/275 (3%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 299 HSAISRLKDSHAHLSPDSTK------ELVALQGQH 327
HS+ISRLK++H+HLS + TK ELV+ G +
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNY 284
Score = 211 bits (538), Expect = 1e-54
Identities = 109/227 (48%), Positives = 147/227 (64%), Gaps = 9/227 (3%)
Query: 319 ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPF--NAP 376
ELV+LQ N DL++LLTLSLDL++TED+IY+LS EPR KS P SP N P
Sbjct: 339 ELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKP 398
Query: 377 LV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHG 435
+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NFPF
Sbjct: 399 VVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFL-DS 457
Query: 436 LHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWG 494
+ G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C+GFLWG
Sbjct: 458 FCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWG 517
Query: 495 VTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 537
+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 518 IIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 217 bits (552), Expect = 3e-56
Identities = 123/275 (44%), Positives = 170/275 (61%), Gaps = 9/275 (3%)
Query: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
Query: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
Query: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
Query: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 299 HSAISRLKDSHAHLSPDSTK------ELVALQGQH 327
HS+ISRLK++H+HLS + TK ELV+ G +
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNY 284
Score = 207 bits (528), Expect = 2e-53
Identities = 109/227 (48%), Positives = 147/227 (64%), Gaps = 10/227 (4%)
Query: 319 ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPF--NAP 376
ELV+LQ N DL++LLTLSLDL++TED+IY+LS EPR KS P SP N P
Sbjct: 339 ELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKS-PTSPTTPNKP 397
Query: 377 LV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHG 435
+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NFPF
Sbjct: 398 VVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFL-DS 456
Query: 436 LHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWG 494
+ G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C+GFLWG
Sbjct: 457 FCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWG 516
Query: 495 VTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 537
+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 517 IIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 563
>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
Length = 1591
Score = 70.1 bits (170), Expect = 6e-12
Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 444 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 501
R S EEL ++ + + A+ + H F T PT+C C G LWG+ +QG R
Sbjct: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
Query: 502 CRECGLCCHKHCRDQVKVECKKRPGAK 528
C ECG+ CH+ C+D + +C +R K
Sbjct: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 69.3 bits (168), Expect = 1e-11
Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 444 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 501
R S + EEL ++ + + A+ + H F T PT+C C G LWG+ +QG +
Sbjct: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127
Query: 502 CRECGLCCHKHCRDQVKVECKKRPGAK 528
C ECG+ CH+ C+D + +C +R K
Sbjct: 1128 CLECGVKCHEKCQDLLNADCLQRAAEK 1154
>gi|122937247 unc-13 homolog A [Homo sapiens]
Length = 1791
Score = 68.9 bits (167), Expect = 1e-11
Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 446 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 503
+ + EEL ++ + + A+ + H F T PT+C C G LWG+ +QG RC
Sbjct: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
Query: 504 ECGLCCHKHCRDQVKVECKKRPGAK 528
ECG+ CH+ C+D + +C +R K
Sbjct: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 66.6 bits (161), Expect = 6e-11
Identities = 43/131 (32%), Positives = 60/131 (45%), Gaps = 14/131 (10%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC---KKRPGAK 528
HT + +++ PTFCD C LWG+ +QG +C CGL HK C ++ C +KR +
Sbjct: 155 HTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSN 214
Query: 529 GDAGPPGAPVPSTPAP-HASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTV 587
PG VP P + + SEE+H + EP +W S P W V
Sbjct: 215 VSLPGPGLSVPRPLQPEYVALPSEESHVHQ---EPSKRIP---SW----SGRPIWMEKMV 264
Query: 588 PCPVMDPPSTA 598
C V P + A
Sbjct: 265 MCRVKVPHTFA 275
Score = 51.2 bits (121), Expect = 3e-06
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
HTF ++ +PT C C L G+ +QG +C++C CHK C +V +C
Sbjct: 272 HTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDC 321
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 63.2 bits (152), Expect = 7e-10
Identities = 24/50 (48%), Positives = 31/50 (62%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
H F F +PTFC C F+WG+ KQGY+CR+C HK C D+V +C
Sbjct: 160 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 209
Score = 53.5 bits (127), Expect = 5e-07
Identities = 19/50 (38%), Positives = 28/50 (56%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
H F ++ PTFC+ C LWG+ +QG +C CG+ H C+ +V C
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 281
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 62.8 bits (151), Expect = 9e-10
Identities = 36/96 (37%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 438 PPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTK 497
PPP +G S R G L + + K H F F++PTFC C+ F+WG K
Sbjct: 8 PPPSEGEESTVRFARKGALRQKNVHEVKN-----HKFTARFFKQPTFCSHCTDFIWGFGK 62
Query: 498 QGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 533
QG++C+ C HK C + V C PGA D GP
Sbjct: 63 QGFQCQVCCFVVHKRCHEFVTFSC---PGA--DKGP 93
Score = 47.0 bits (110), Expect = 5e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 62.8 bits (151), Expect = 9e-10
Identities = 36/96 (37%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 438 PPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTK 497
PPP +G S R G L + + K H F F++PTFC C+ F+WG K
Sbjct: 8 PPPSEGEESTVRFARKGALRQKNVHEVKN-----HKFTARFFKQPTFCSHCTDFIWGFGK 62
Query: 498 QGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGP 533
QG++C+ C HK C + V C PGA D GP
Sbjct: 63 QGFQCQVCCFVVHKRCHEFVTFSC---PGA--DKGP 93
Score = 47.0 bits (110), Expect = 5e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 62.0 bits (149), Expect = 2e-09
Identities = 23/50 (46%), Positives = 30/50 (60%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
H F F +PTFC C F+WG+ KQGY+CR+C HK C D++ C
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 208
Score = 59.3 bits (142), Expect = 1e-08
Identities = 22/50 (44%), Positives = 29/50 (58%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
H F + PTFCD C LWG+ KQG +C +CG+ H CR++V C
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 62.0 bits (149), Expect = 2e-09
Identities = 23/50 (46%), Positives = 30/50 (60%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
H F F +PTFC C F+WG+ KQGY+CR+C HK C D++ C
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 208
Score = 59.3 bits (142), Expect = 1e-08
Identities = 22/50 (44%), Positives = 29/50 (58%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
H F + PTFCD C LWG+ KQG +C +CG+ H CR++V C
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 280
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 61.2 bits (147), Expect = 3e-09
Identities = 29/82 (35%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Query: 443 GRGSFSREELTGYLLRASAICSKLGLAF--LHTFHEVTFRKPTFCDSCSGFLWGVTKQGY 500
G+ S + LT + RA+ ++ + +H F TFR P +C+ C+ F+WG+ QG
Sbjct: 175 GQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGV 234
Query: 501 RCRECGLCCHKHCRDQVKVECK 522
+C +CGL HK C V +CK
Sbjct: 235 KCADCGLNVHKQCSKMVPNDCK 256
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 59.7 bits (143), Expect = 8e-09
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 522
H F TFR P +C+ C+ F+WG+ QG RC +CGL HK C V +C+
Sbjct: 215 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQ 265
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 59.7 bits (143), Expect = 8e-09
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 522
H F TFR P +C+ C+ F+WG+ QG RC +CGL HK C V +C+
Sbjct: 79 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQ 129
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 59.7 bits (143), Expect = 8e-09
Identities = 24/56 (42%), Positives = 33/56 (58%), Gaps = 3/56 (5%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA 527
H F F++PTFC C+ F+WG+ KQG +C+ C H+ C + V EC PGA
Sbjct: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFEC---PGA 88
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/50 (36%), Positives = 25/50 (50%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
H F ++ PTFCD C L+G+ QG +C C + H+ C V C
Sbjct: 101 HKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC 150
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 59.3 bits (142), Expect = 1e-08
Identities = 27/62 (43%), Positives = 35/62 (56%), Gaps = 5/62 (8%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA 531
H F F++PTFC C+ F+WG KQG++C+ C HK C + V C PGA D
Sbjct: 37 HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC---PGA--DK 91
Query: 532 GP 533
GP
Sbjct: 92 GP 93
Score = 47.4 bits (111), Expect = 4e-05
Identities = 20/50 (40%), Positives = 25/50 (50%)
Query: 472 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
H F T+ PTFCD C L+G+ QG +C C + HK C V C
Sbjct: 102 HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLC 151
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 57.0 bits (136), Expect = 5e-08
Identities = 21/45 (46%), Positives = 29/45 (64%)
Query: 478 TFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECK 522
TFR P +C+ C+ F+WG+ QG +C +CGL HK C V +CK
Sbjct: 186 TFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCK 230
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,345,169
Number of Sequences: 37866
Number of extensions: 1573944
Number of successful extensions: 12002
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 64
Number of HSP's that attempted gapping in prelim test: 10618
Number of HSP's gapped (non-prelim): 1439
length of query: 604
length of database: 18,247,518
effective HSP length: 108
effective length of query: 496
effective length of database: 14,157,990
effective search space: 7022363040
effective search space used: 7022363040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.