Search of human proteins with 225579078

Search of human proteins with 225579078

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
         (331 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]        657   0.0  
gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]         520   e-148
gi|186928839 retinol dehydrogenase 12 [Homo sapiens]                  286   1e-77
gi|166795268 retinol dehydrogenase 11 [Homo sapiens]                  285   3e-77
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo...   279   2e-75
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom...   233   2e-61
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo...   202   4e-52
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s...   187   9e-48
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         76   4e-14
gi|13375997 dehydrogenase/reductase (SDR family) member 12 isofo...    74   1e-13
gi|72534732 dehydrogenase/reductase (SDR family) member 12 isofo...    70   3e-12
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    70   3e-12
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    70   3e-12
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    68   1e-11
gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens]     67   2e-11
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    67   2e-11
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     67   2e-11
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...    65   8e-11
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]         65   8e-11
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    64   1e-10
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    64   2e-10
gi|40254992 carbonic reductase 4 [Homo sapiens]                        62   5e-10
gi|4502601 carbonyl reductase 3 [Homo sapiens]                         62   7e-10
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           62   9e-10
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]              62   9e-10
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    61   1e-09
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   60   3e-09
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    60   4e-09
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    60   4e-09
gi|4502599 carbonyl reductase 1 [Homo sapiens]                         59   5e-09

>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score =  657 bits (1695), Expect = 0.0
 Identities = 331/331 (100%), Positives = 331/331 (100%)

Query: 1   MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELAR 60
           MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELAR
Sbjct: 1   MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELAR 60

Query: 61  RGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDI 120
           RGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDI
Sbjct: 61  RGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDI 120

Query: 121 LINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAG 180
           LINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAG
Sbjct: 121 LINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAG 180

Query: 181 HIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRH 240
           HIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRH
Sbjct: 181 HIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRH 240

Query: 241 TGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEA 300
           TGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEA
Sbjct: 241 TGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEA 300

Query: 301 EDEEVARRLWAESARLVGLEAPSVREQPLPR 331
           EDEEVARRLWAESARLVGLEAPSVREQPLPR
Sbjct: 301 EDEEVARRLWAESARLVGLEAPSVREQPLPR 331


>gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]
          Length = 260

 Score =  520 bits (1340), Expect = e-148
 Identities = 260/260 (100%), Positives = 260/260 (100%)

Query: 72  MEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCP 131
           MEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCP
Sbjct: 1   MEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCP 60

Query: 132 HWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQT 191
           HWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQT
Sbjct: 61  HWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQT 120

Query: 192 RKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSST 251
           RKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSST
Sbjct: 121 RKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSST 180

Query: 252 TLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWA 311
           TLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWA
Sbjct: 181 TLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWA 240

Query: 312 ESARLVGLEAPSVREQPLPR 331
           ESARLVGLEAPSVREQPLPR
Sbjct: 241 ESARLVGLEAPSVREQPLPR 260


>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
          Length = 316

 Score =  286 bits (733), Expect = 1e-77
 Identities = 151/299 (50%), Positives = 200/299 (66%), Gaps = 7/299 (2%)

Query: 21  LKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAK 80
           ++ +  GG C +   +PGK V++TGANTGIGK+TA ELA RG  + +ACRD+ K E+AA 
Sbjct: 22  IRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAAS 81

Query: 81  DIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFE 140
           +IR +T N  V  R LDL+  KSIR FA   + EE+++ ILINNAGVM CP+  T DGFE
Sbjct: 82  EIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFE 141

Query: 141 MQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAY 200
              GVNHLGHFLLT LLL++LK SAP+R++N+SS+AH  G I F DL    ++Y+   AY
Sbjct: 142 THLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQ-SEKRYSRGFAY 200

Query: 201 CQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLL 260
           C SKLA VLFT+EL++RLQG+GVT  A+HPGV R+EL RH+ +         L  +F   
Sbjct: 201 CHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSL------LCLLWRLFSPF 254

Query: 261 VKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGL 319
           VK+    AQ S + A+AE L  +SGKYF   K+   +P A + + A RLW  S  L+G+
Sbjct: 255 VKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGI 313


>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
          Length = 318

 Score =  285 bits (730), Expect = 3e-77
 Identities = 155/306 (50%), Positives = 204/306 (66%), Gaps = 13/306 (4%)

Query: 17  AAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCE 76
           AA  ++  ++ G C S   +PGK V+VTGANTGIGK+TA ELA+RG  + LACRD+EK E
Sbjct: 20  AAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGE 79

Query: 77  AAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTE 136
             AK+I+  T N  V  R LDL+  KSIR FA   + EE+ + +LINNAGVM CP+  T 
Sbjct: 80  LVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTA 139

Query: 137 DGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNT 196
           DGFEM  GVNHLGHFLLT+LLL+KLK SAPSRI+N+SSLAH  G I F +L  + + YN 
Sbjct: 140 DGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGE-KFYNA 198

Query: 197 KAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPI 256
             AYC SKLA +LFT+EL+RRL+GSGVT  ++HPG  ++EL RH         S+ +  +
Sbjct: 199 GLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRH---------SSFMRWM 249

Query: 257 FWL---LVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAES 313
           +WL    +K+P+  AQ S + A+ E L  +SG +F        + +A +E +ARRLW  S
Sbjct: 250 WWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVS 309

Query: 314 ARLVGL 319
             L+GL
Sbjct: 310 CDLLGL 315


>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
           sapiens]
          Length = 336

 Score =  279 bits (714), Expect = 2e-75
 Identities = 149/295 (50%), Positives = 193/295 (65%), Gaps = 16/295 (5%)

Query: 38  GKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNH-------- 89
           GKTV++TGAN+G+G+ TA EL R G  +I+ CRD  + E AA  +R E            
Sbjct: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102

Query: 90  -----HVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFG 144
                 +  R LDLASL+S+R F  ++++EE R+D+LINNAG+ +CP+  TEDGFEMQFG
Sbjct: 103 VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFG 162

Query: 145 VNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSK 204
           VNHLGHFLLTNLLL  LK+SAPSRI+ +SS  +  G I+FDDLN   + YN    Y +SK
Sbjct: 163 VNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLN-SEQSYNKSFCYSRSK 221

Query: 205 LAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSP 264
           LA +LFT+EL+RRL+G+ VTVN LHPG+ RT LGRH  IH           + W   K+P
Sbjct: 222 LANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRH--IHIPLLVKPLFNLVSWAFFKTP 279

Query: 265 ELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGL 319
              AQ S YLA + E+  VSG+YF   K++   P+A DE VAR+LW  S  +VGL
Sbjct: 280 VEGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGL 334


>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
           sapiens]
          Length = 377

 Score =  233 bits (593), Expect = 2e-61
 Identities = 136/314 (43%), Positives = 185/314 (58%), Gaps = 7/314 (2%)

Query: 8   LSALGTVAGAAVLLK-DYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNII 66
           L   G + GA VL+  + V    C     + G+T +VTGAN+GIGK TALELARRG  ++
Sbjct: 5   LLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVV 64

Query: 67  LACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAG 126
           LACR  E+ EAAA D+R E+ N+ V    LDLASL S+R FA   +  E R+DILI+NAG
Sbjct: 65  LACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAG 124

Query: 127 VMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDD 186
           +  C    T + F +   VNH+G FLLT+LLL  LKA APSR++ ++S AH  G +DF  
Sbjct: 125 ISSCGR--TREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKR 182

Query: 187 LNWQTRKYNTK-AAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHG 245
           L+     +  +  AY  +KLA VLF +EL+ +L+ +GVT  A HPG   +EL      H 
Sbjct: 183 LDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLR---HV 239

Query: 246 STFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEV 305
             +    L P+ WL++++P   AQ   Y A+ E +  +SG+YF     +   P A D+  
Sbjct: 240 PGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRA 299

Query: 306 ARRLWAESARLVGL 319
           A RLW  S RL GL
Sbjct: 300 AHRLWEASKRLAGL 313


>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
           sapiens]
          Length = 330

 Score =  202 bits (513), Expect = 4e-52
 Identities = 128/324 (39%), Positives = 177/324 (54%), Gaps = 11/324 (3%)

Query: 2   SRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARR 61
           +R  L + A+G     A LL+    G   P     P +  IVTG   GIG  TA  LAR 
Sbjct: 7   ARAALRVYAVGAAVILAQLLRRCRGGFLEPVFPPRPDRVAIVTGGTDGIGYSTAKHLARL 66

Query: 62  GGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDIL 121
           G ++I+A  +  K +     I+ ETLN  V   + DLAS+ SIR+F  K   ++  + +L
Sbjct: 67  GMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLASMTSIRQFVQKFKMKKIPLHVL 126

Query: 122 INNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASA----PSRIINLSSLAH 177
           INNAGVM  P   T DGFE  FG+N+LGHFLLTNLLLD LK S      +R++ +SS  H
Sbjct: 127 INNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATH 186

Query: 178 VAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRL--QGSGVTVNALHPGVART 235
               ++ DDL   +  Y+  AAY QSKLA+VLFT  L R L  +GS VT N + PGV  T
Sbjct: 187 YVAELNMDDLQ-SSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDPGVVNT 245

Query: 236 ELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKA 295
           ++ +H     +  +   LG   WLL K+P+  A  S Y AV  EL  V G Y    K+  
Sbjct: 246 DVYKHV-FWATRLAKKLLG---WLLFKTPDEGAWTSIYAAVTPELEGVGGHYLYNEKETK 301

Query: 296 PAPEAEDEEVARRLWAESARLVGL 319
                 ++++ ++LW++S  + G+
Sbjct: 302 SLHVTYNQKLQQQLWSKSCEMTGV 325


>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
           sapiens]
          Length = 414

 Score =  187 bits (476), Expect = 9e-48
 Identities = 117/287 (40%), Positives = 154/287 (53%), Gaps = 12/287 (4%)

Query: 38  GKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLD 97
           GK V+VTGAN+GIG +TA   A  G ++ILACR+M +   A   I  E     V A  LD
Sbjct: 124 GKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLD 183

Query: 98  LASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLL 157
           LA L+S++ FA     +   + +L+ NA     P   T+DG E  F VNHLGHF L  LL
Sbjct: 184 LALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLL 243

Query: 158 LDKLKASAPSRIINLSSLAH-------VAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF 210
            D L  SAP+R+I +SS +H         G +DF  L+     Y    AY +SKL  +LF
Sbjct: 244 QDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILF 303

Query: 211 TKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQP 270
           + EL RRL   GVT NA+HPG        ++ IH S +  T L  +     KS +  A  
Sbjct: 304 SNELHRRLSPRGVTSNAVHPGNM-----MYSNIHRSWWVYTLLFTLARPFTKSMQQGAAT 358

Query: 271 STYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLV 317
           + Y A   EL  + G YF+   +  P+PEA+ EE AR LWA S RL+
Sbjct: 359 TVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLI 405


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 69/228 (30%), Positives = 101/228 (44%), Gaps = 28/228 (12%)

Query: 33  KATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVN 92
           + ++ G+ V++TGA  GIG+ TA E A+    ++L   +    E  A   +G  L   V+
Sbjct: 31  RKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKG--LGAKVH 88

Query: 93  ARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHW--TTEDGFEMQFGVNHLGH 150
              +D ++ + I   A K+  E   V IL+NNAGV+       T +   E  F VN L H
Sbjct: 89  TFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAH 148

Query: 151 FLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF 210
           F  T   L  +  +    I+ ++S    AGH+    L           AYC SK A V F
Sbjct: 149 FWTTKAFLPAMTKNNHGHIVTVAS---AAGHVSVPFL----------LAYCSSKFAAVGF 195

Query: 211 TKELS---RRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGP 255
            K L+     LQ +GV    L P    T   ++         ST+LGP
Sbjct: 196 HKTLTDELAALQITGVKTTCLCPNFVNTGFIKN--------PSTSLGP 235


>gi|13375997 dehydrogenase/reductase (SDR family) member 12 isoform
           2 [Homo sapiens]
          Length = 242

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 63/208 (30%), Positives = 101/208 (48%), Gaps = 13/208 (6%)

Query: 72  MEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCP 131
           +E+  A AK +  ++ + ++    +DL+  K I +F     ++E ++ +LINNAG M   
Sbjct: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENF-KQEHKLHVLINNAGCMVNK 83

Query: 132 HWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQT 191
              TEDG E  F  N LG ++LT  L+  L+     R+I +SS   +   ++ +DL  + 
Sbjct: 84  RELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSER 143

Query: 192 RKYNTKAAYCQSKLAIVLFTKELSRRLQG-SGVTVNALHPGVARTELGRHT--GIH---G 245
             ++    Y Q+K   V+ T+   R  QG   +  +++HPG A T   R    G H   G
Sbjct: 144 TPFDGTMVYAQNKRQQVVLTE---RWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFG 200

Query: 246 STFSSTTLG--PIFWLLVKSPELAAQPS 271
               S   G   + WL + S   AAQPS
Sbjct: 201 DRLRSEAQGADTMLWLALSS-AAAAQPS 227


>gi|72534732 dehydrogenase/reductase (SDR family) member 12 isoform
           1 [Homo sapiens]
          Length = 271

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 49/165 (29%), Positives = 85/165 (51%), Gaps = 5/165 (3%)

Query: 72  MEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCP 131
           +E+  A AK +  ++ + ++    +DL+  K I +F     ++E ++ +LINNAG M   
Sbjct: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENF-KQEHKLHVLINNAGCMVNK 83

Query: 132 HWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQT 191
              TEDG E  F  N LG ++LT  L+  L+     R+I +SS   +   ++ +DL  + 
Sbjct: 84  RELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSER 143

Query: 192 RKYNTKAAYCQSKLAIVLFTKELSRRLQG-SGVTVNALHPGVART 235
             ++    Y Q+K   V+ T+   R  QG   +  +++HPG A T
Sbjct: 144 TPFDGTMVYAQNKRQQVVLTE---RWAQGHPAIHFSSMHPGWADT 185


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 63/210 (30%), Positives = 94/210 (44%), Gaps = 30/210 (14%)

Query: 36  IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDME---KCEAAAKDIRGETLNHHVN 92
           + GK  +VTGA  GIG+  A  L  +G  + L   ++E   +C+AA  +         + 
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62

Query: 93  ARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFL 152
               D+A  + +R+   K+++   R+DIL+NNAGV        E  +E    +N +    
Sbjct: 63  C---DVADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKTLQINLVSVIS 113

Query: 153 LTNLLLD---KLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVL 209
            T L LD   K        IIN+SSLA +                  +  YC SK  IV 
Sbjct: 114 GTYLGLDYMSKQNGGEGGIIINMSSLAGL-------------MPVAQQPVYCASKHGIVG 160

Query: 210 FTKE--LSRRLQGSGVTVNALHPGVARTEL 237
           FT+   L+  L  SGV +NA+ PG   T +
Sbjct: 161 FTRSAALAANLMNSGVRLNAICPGFVNTAI 190


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 57/194 (29%), Positives = 89/194 (45%), Gaps = 17/194 (8%)

Query: 33  KATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVN 92
           + ++ G+ V++TGA  GIG+QT  E A+R   ++L   +    E  A + R   +  H  
Sbjct: 31  RKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAH-- 88

Query: 93  ARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHW--TTEDGFEMQFGVNHLGH 150
           A  +D ++ + I     ++ +E   V I++NNAG +       T ++     F VN LGH
Sbjct: 89  AYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGH 148

Query: 151 FLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF 210
           F +T  LL  +       I+ ++S   V GH     L            YC SK A V F
Sbjct: 149 FWITKALLPSMMERNHGHIVTVAS---VCGHEGIPYL----------IPYCSSKFAAVGF 195

Query: 211 TKELSRRLQGSGVT 224
            + L+  LQ  G T
Sbjct: 196 HRGLTSELQALGKT 209


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 58/201 (28%), Positives = 99/201 (49%), Gaps = 27/201 (13%)

Query: 41  VIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLAS 100
           V +TG ++G G+  AL+L +RG  ++ +C       + A+D++    +  ++   LD+  
Sbjct: 31  VFITGCDSGFGRLLALQLDQRGFRVLASC----LTPSGAEDLQ-RVASSRLHTTLLDITD 85

Query: 101 LKSIREFAAKIIE---EEERVDILINNAGV---MRCPHWTTEDGFEMQFGVNHLGHFLLT 154
            +S+++ AAK +E   +E  +  L+NNAGV   +    W T D F+    VN +G   +T
Sbjct: 86  PQSVQQ-AAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVT 144

Query: 155 NLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKEL 214
             LL  L+  A  R+IN++S   V G +  +              YC SK  +  F+  L
Sbjct: 145 LALLPLLQ-QARGRVINITS---VLGRLAANG-----------GGYCVSKFGLEAFSDSL 189

Query: 215 SRRLQGSGVTVNALHPGVART 235
            R +   G+ V+ + PG  RT
Sbjct: 190 RRDVAHFGIRVSIVEPGFFRT 210


>gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens]
          Length = 341

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 60/232 (25%), Positives = 94/232 (40%), Gaps = 37/232 (15%)

Query: 39  KTVIVTGANTGIGKQTALELARRGG--NIILACRDMEKCEAAAKDIRGETLNHHVNARHL 96
           K V++TGA++GIG      L       ++ LACR+M K EA    +        V    +
Sbjct: 3   KVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQV 62

Query: 97  DLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWT---------------------- 134
           D+++L+S+   + ++ +  +R+D +  NAG+M  P                         
Sbjct: 63  DVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEG 122

Query: 135 --------TEDGFEMQFGVNHLGHFLLTNLLLDKL-KASAPSRIINLSSLAHVAGHIDFD 185
                   T DG +  F  N  GHF+L   L   L  +  PS++I  SS +    +   +
Sbjct: 123 LLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLE 182

Query: 186 DLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTEL 237
           D     +    K  Y  SK A  L +  L+R     G+  N   PG A T L
Sbjct: 183 DF----QHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNL 230


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 60/209 (28%), Positives = 96/209 (45%), Gaps = 27/209 (12%)

Query: 39  KTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDL 98
           K V +TG ++G G   A +L  RG  ++ AC      E  A+ +RG+T +  +    LD+
Sbjct: 30  KYVFITGCDSGFGNLLARQLDARGLRVLAACLT----EKGAEQLRGQT-SDRLETVTLDV 84

Query: 99  ASLKSIREFAAKIIEE--EERVDILINNAGVMR----CPHWTTEDGFEMQFGVNHLGHFL 152
             ++SI      + E   +  +  L+NNAG++     C    TED   M   VN +G   
Sbjct: 85  TKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNM-LKVNLIGVIQ 143

Query: 153 LTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTK 212
           +T  +L  ++  A  RI+N+SS   + G + F               YC SK  +  F+ 
Sbjct: 144 VTLSMLPLVRR-ARGRIVNVSS---ILGRVAF-----------FVGGYCVSKYGVEAFSD 188

Query: 213 ELSRRLQGSGVTVNALHPGVARTELGRHT 241
            L R +Q  GV ++ + PG  RT +   T
Sbjct: 189 ILRREIQHFGVKISIVEPGYFRTGMTNMT 217


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 57/205 (27%), Positives = 88/205 (42%), Gaps = 31/205 (15%)

Query: 36  IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARH 95
           + GK +I+T A  GIG+  AL  AR G  +I    +  K +   K          +  R 
Sbjct: 4   LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEK-------YPGIQTRV 56

Query: 96  LDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTT----EDGFEMQFGVNHLGHF 151
           LD+   K I +FA     E ER+D+L N AG +   H T     E  ++    +N    +
Sbjct: 57  LDVTKKKQIDQFA----NEVERLDVLFNVAGFVH--HGTVLDCEEKDWDFSMNLNVRSMY 110

Query: 152 LLTNLLLDKLKASAPSRIINLSSLA-HVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF 210
           L+    L K+ A     IIN+SS+A  V G ++             +  Y  +K A++  
Sbjct: 111 LMIKAFLPKMLAQKSGNIINMSSVASSVKGVVN-------------RCVYSTTKAAVIGL 157

Query: 211 TKELSRRLQGSGVTVNALHPGVART 235
           TK ++      G+  N + PG   T
Sbjct: 158 TKSVAADFIQQGIRCNCVCPGTVDT 182


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 57/213 (26%), Positives = 91/213 (42%), Gaps = 25/213 (11%)

Query: 30  CPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNH 89
           C     +  K V +TG ++G G   A +L  RG  ++ AC   E  +   +D      ++
Sbjct: 17  CNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRD-----TSY 71

Query: 90  HVNARHLDLASLKSIREFAAKIIEE--EERVDILINNAGV---MRCPHWTTEDGFEMQFG 144
            +    LD+   +SI+  A  + ++  E+ +  L+NNAGV        W T+D F     
Sbjct: 72  RLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVIN 131

Query: 145 VNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSK 204
           VN +G   +T  +L  +K  A  R++N+SS       I                 YC SK
Sbjct: 132 VNLVGLIEVTLHMLPMVK-RARGRVVNMSSSGGRVAVIG--------------GGYCVSK 176

Query: 205 LAIVLFTKELSRRLQGSGVTVNALHPGVARTEL 237
             +  F+  + R L   GV V  + PG  RT +
Sbjct: 177 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAI 209


>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
          Length = 418

 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 55/212 (25%), Positives = 94/212 (44%), Gaps = 23/212 (10%)

Query: 31  PSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDME-------KCEAAAKDIR 83
           P+   + G TV +TGA+ GIGK  AL+ A+ G NI++A +  +           AA++I 
Sbjct: 3   PNTGRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEI- 61

Query: 84  GETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHW--TTEDGFEM 141
            E +        +D+   + I     K I++   +DIL+NNA  +   +   T     ++
Sbjct: 62  -EAVGGKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDL 120

Query: 142 QFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYC 201
              VN  G +L +   +  LK S  + I+N+S             LN     +    AY 
Sbjct: 121 MMNVNTRGTYLASKACIPYLKKSKVAHILNIS-----------PPLNLNPVWFKQHCAYT 169

Query: 202 QSKLAIVLFTKELSRRLQGSGVTVNALHPGVA 233
            +K  + ++   ++   +G  + VNAL P  A
Sbjct: 170 IAKYGMSMYVLGMAEEFKGE-IAVNALWPKTA 200


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 54/203 (26%), Positives = 81/203 (39%), Gaps = 23/203 (11%)

Query: 38  GKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLD 97
           GK V+VTG   GIG          G  +++  +D     A  +++ G            D
Sbjct: 9   GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVF------ILCD 62

Query: 98  LASLKSIREFAAKIIEEEERVDILINNAG---VMRCPHWTTEDGFEMQFGVNHLGHFLLT 154
           +     ++   ++ I    R+D ++NNAG     + P  T+  GF     +N LG + LT
Sbjct: 63  VTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122

Query: 155 NLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKEL 214
            L L  L+ S    +IN+SSL    G                   Y  +K A+   TK L
Sbjct: 123 KLALPYLRKS-QGNVINISSLVGAIGQAQ-------------AVPYVATKGAVTAMTKAL 168

Query: 215 SRRLQGSGVTVNALHPGVARTEL 237
           +      GV VN + PG   T L
Sbjct: 169 ALDESPYGVRVNCISPGNIWTPL 191


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 57/219 (26%), Positives = 95/219 (43%), Gaps = 18/219 (8%)

Query: 17  AAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCE 76
           A VLL   V+    P    +PG  V+VTG ++GIGK  A+E  ++G  I L  R+ +K  
Sbjct: 11  AFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLL 70

Query: 77  AAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEER---VDILINNAGVMRCPHW 133
            A K+I   ++N       + +   +   +    I + +E+   VD+L+N AG+     +
Sbjct: 71  QAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKF 130

Query: 134 TTED--GFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQT 191
              +   FE    +N+LG    +  ++  +K     RI+ +SS A   G   F       
Sbjct: 131 EDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGF------- 183

Query: 192 RKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHP 230
                  AY  SK AI    + L   ++   V +   +P
Sbjct: 184 ------TAYSASKFAIRGLAEALQMEVKPYNVYITVAYP 216


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 51/202 (25%), Positives = 91/202 (45%), Gaps = 22/202 (10%)

Query: 39  KTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDL 98
           K   V G + GIG+  A  +AR+G  + +  R++E  +AAA D+ G+ L     A   D+
Sbjct: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHL-----AFSCDV 57

Query: 99  ASLKSIREFAAKIIEEEERVDILINNAGVMR---CPHWTTEDGFEMQFGVNHLGHFLLTN 155
           A    ++    ++ +   RV+ L+N AG+ R        TED    Q   N LG  L   
Sbjct: 58  AKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTED-MVSQLHTNLLGSMLTCK 116

Query: 156 LLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELS 215
             +  +       I+N+ S+  + G+             + ++ Y  SK  +V F++ L+
Sbjct: 117 AAMRTMIQQQGGSIVNVGSIVGLKGN-------------SGQSVYSASKGGLVGFSRALA 163

Query: 216 RRLQGSGVTVNALHPGVARTEL 237
           + +    + VN + PG   T++
Sbjct: 164 KEVARKKIRVNVVAPGFVHTDM 185


>gi|4502601 carbonyl reductase 3 [Homo sapiens]
          Length = 277

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 72/275 (26%), Positives = 122/275 (44%), Gaps = 51/275 (18%)

Query: 39  KTVIVTGANTGIGKQTALELARR-GGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLD 97
           +  +VTGAN GIG   A EL R+  G+++L  RD+ + +AA + ++ E L+   +   LD
Sbjct: 6   RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH--QLD 63

Query: 98  LASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGF------EMQFGVNHLGHF 151
           +  L+SIR     + +E   +++L+NNA V     + ++D        EM    N     
Sbjct: 64  IDDLQSIRALRDFLRKEYGGLNVLVNNAAVA----FKSDDPMPFDIKAEMTLKTNFFATR 119

Query: 152 LLTNLLLDKLKASAPSRIINLSSLAHVAGH---------------IDFDDLNWQTRKY-- 194
            + N LL  +K     R++N+SSL  +                  +   DL    +K+  
Sbjct: 120 NMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177

Query: 195 NTK-----------AAYCQSKLAIVLFTKELSRRL----QGSGVTVNALHPGVARTELGR 239
           +TK           + Y  SKL + + ++ L+RRL    +   + VNA  PG  +T++  
Sbjct: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237

Query: 240 HTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYL 274
              I   T       P++  L+  P  A +P   L
Sbjct: 238 KDSIR--TVEEGAETPVYLALL--PPDATEPQGQL 268


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 52/188 (27%), Positives = 84/188 (44%), Gaps = 24/188 (12%)

Query: 33  KATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVN 92
           +  + G+ V++TGA +G+G+  AL+ AR G  ++L   + E  E   K  R E     V+
Sbjct: 35  RKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAR-EAGATRVH 93

Query: 93  ARHLDLASLKSIREFAAKIIEEEERVDILINNAGV------MRCPHWTTEDGFEMQFGVN 146
           A   D +  + +   A ++ +E   V ILINNAG+      + CP    ++  E  F VN
Sbjct: 94  AYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCP----DELMEKSFDVN 149

Query: 147 HLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLA 206
              H       L  + A+    ++ +SS A ++G              N  A YC SK A
Sbjct: 150 FKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSG-------------VNGLADYCASKFA 196

Query: 207 IVLFTKEL 214
              F + +
Sbjct: 197 AFGFAESV 204


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 51/209 (24%), Positives = 89/209 (42%), Gaps = 26/209 (12%)

Query: 36  IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARH 95
           + G+ V+VTGA  GIG+ T   L   G  ++   R     ++  ++  G      +    
Sbjct: 5   LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG------IEPVC 58

Query: 96  LDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHW--TTEDGFEMQFGVNHLGHFLL 153
           +DL   ++       +      VD+L+NNA V     +   T++ F+  F VN      +
Sbjct: 59  VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114

Query: 154 TNLLLDKLKA-SAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTK 212
           + ++   L A   P  I+N+SS                 R     + YC +K A+ + TK
Sbjct: 115 SQIVARGLIARGVPGAIVNVSSQC-------------SQRAVTNHSVYCSTKGALDMLTK 161

Query: 213 ELSRRLQGSGVTVNALHPGVARTELGRHT 241
            ++  L    + VNA++P V  T +G+ T
Sbjct: 162 VMALELGPHKIRVNAVNPTVVMTSMGQAT 190


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 59/228 (25%), Positives = 102/228 (44%), Gaps = 27/228 (11%)

Query: 33  KATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVN 92
           K  +  +  +VTG+ +GIG   A  LAR G +++++ R  +  + A   ++GE L+    
Sbjct: 31  KGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGI 90

Query: 93  ARHLDLASLKSIREFAAKIIEEEERVDILINNAGV---MRCPHWTTEDGFEMQFGVNHLG 149
             H+  A  +   +  AK +E    VD L+ +AGV   +     T+E  ++    VN   
Sbjct: 91  VCHVGKA--EDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKS 148

Query: 150 HFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAA---YCQSKLA 206
             LL + LL  ++ +    +I +SS+A                 YN   A   Y  SK A
Sbjct: 149 PALLLSQLLPYME-NRRGAVILVSSIA----------------AYNPVVALGVYNVSKTA 191

Query: 207 IVLFTKELSRRLQGSGVTVNALHPGVARTELGR--HTGIHGSTFSSTT 252
           ++  T+ L+  L    + VN + PG+ +T+  +    G  G + S  T
Sbjct: 192 LLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSGRT 239


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 60/202 (29%), Positives = 91/202 (45%), Gaps = 25/202 (12%)

Query: 39  KTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDL 98
           K V +TG ++G GK  A +L  RG  ++ AC      E  A+ +RG+T +  +    LD+
Sbjct: 30  KYVFITGCDSGFGKLLARQLDARGLRVLAAC----LTEKGAEQLRGQT-SDRLETVTLDV 84

Query: 99  ASLKSIREFAAKIIE--EEERVDILINNAGVM--RCPH-WTTEDGFEMQFGVNHLGHFLL 153
              +S+   A  + E   ++ +  L+NNAG+     P+   T+  F     VN LG   +
Sbjct: 85  TKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDV 144

Query: 154 TNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKE 213
           T  LL  L   A  R++N+SS   V G +                 YC SK  +  F+  
Sbjct: 145 TLSLL-PLVRRARGRVVNVSS---VMGRVSL-----------FGGGYCISKYGVEAFSDS 189

Query: 214 LSRRLQGSGVTVNALHPGVART 235
           L R L   GV V  + PG  +T
Sbjct: 190 LRRELSYFGVKVAMIEPGYFKT 211


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 55/213 (25%), Positives = 97/213 (45%), Gaps = 25/213 (11%)

Query: 33  KATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVN 92
           K  +  +  +VTG+ +GIG   A  LAR G +++++ R  +  + A   ++GE L+    
Sbjct: 31  KGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGI 90

Query: 93  ARHLDLASLKSIREFAAKIIEEEERVDILINNAGV---MRCPHWTTEDGFEMQFGVNHLG 149
             H+  A  +   +  AK +E    VD L+ +AGV   +     T+E  ++    VN   
Sbjct: 91  VCHVGKA--EDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKS 148

Query: 150 HFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAA---YCQSKLA 206
             LL + LL  ++ +    +I +SS+A                 YN   A   Y  SK A
Sbjct: 149 PALLLSQLLPYME-NRRGAVILVSSIA----------------AYNPVVALGVYNVSKTA 191

Query: 207 IVLFTKELSRRLQGSGVTVNALHPGVARTELGR 239
           ++  T+ L+  L    + VN + PG+ +T+  +
Sbjct: 192 LLGLTRTLALELAPKDIRVNCVVPGIIKTDFSK 224


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 49/209 (23%), Positives = 93/209 (44%), Gaps = 22/209 (10%)

Query: 36  IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARH 95
           +  K  +VT +  GIG   A  LA+ G +++++ R  +  + A   ++GE L+      H
Sbjct: 30  LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 89

Query: 96  LDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHW-----TTEDGFEMQFGVNHLGH 150
           +  A  +      A  ++    +DIL++NA V   P +      TE+ ++    +N    
Sbjct: 90  VGKA--EDRERLVATAVKLHGGIDILVSNAAVN--PFFGSIMDVTEEVWDKTLDINVKAP 145

Query: 151 FLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF 210
            L+T  ++ +++      ++ +SS+A  +    F             + Y  SK A++  
Sbjct: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGF-------------SPYNVSKTALLGL 192

Query: 211 TKELSRRLQGSGVTVNALHPGVARTELGR 239
           TK L+  L    + VN L PG+ +T   R
Sbjct: 193 TKTLAIELAPRNIRVNCLAPGLIKTSFSR 221


>gi|4502599 carbonyl reductase 1 [Homo sapiens]
          Length = 277

 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 69/271 (25%), Positives = 121/271 (44%), Gaps = 59/271 (21%)

Query: 42  IVTGANTGIGKQTALELARR-GGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLD-LA 99
           +VTG N GIG     +L R   G+++L  RD+ + +AA + ++ E L+   +   +D L 
Sbjct: 9   LVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQ 68

Query: 100 SLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLD 159
           S++++R+F  K   E   +D+L+NNAG+       T   F +Q  V    +F  T  +  
Sbjct: 69  SIRALRDFLRK---EYGGLDVLVNNAGIAFKVADPTP--FHIQAEVTMKTNFFGTRDVCT 123

Query: 160 KL--KASAPSRIINLSSLAHV---------------AGHIDFDDLNWQTRKY--NTK--- 197
           +L        R++N+SS+  V               +  I  ++L     K+  +TK   
Sbjct: 124 ELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGV 183

Query: 198 --------AAYCQSKLAIVLFT----KELSRRLQGSGVTVNALHPGVARTELGRHTGIHG 245
                   +AY  +K+ + + +    ++LS + +G  + +NA  PG  RT++        
Sbjct: 184 HQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMA------- 236

Query: 246 STFSSTTLGPIFWLLVKSPELAAQPSTYLAV 276
                   GP      KSPE  A+   YLA+
Sbjct: 237 --------GP---KATKSPEEGAETPVYLAL 256


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,024,091
Number of Sequences: 37866
Number of extensions: 503119
Number of successful extensions: 1461
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 1339
Number of HSP's gapped (non-prelim): 91
length of query: 331
length of database: 18,247,518
effective HSP length: 103
effective length of query: 228
effective length of database: 14,347,320
effective search space: 3271188960
effective search space used: 3271188960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.