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Search of human proteins with 22547161
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22547161 frizzled 4 [Homo sapiens]
(537 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22547161 frizzled 4 [Homo sapiens] 1111 0.0
gi|4503835 frizzled 9 [Homo sapiens] 552 e-157
gi|6005762 frizzled 10 [Homo sapiens] 552 e-157
gi|4503827 frizzled 2 [Homo sapiens] 456 e-128
gi|4503825 frizzled 1 [Homo sapiens] 446 e-125
gi|4503833 frizzled 7 [Homo sapiens] 439 e-123
gi|27894385 frizzled 5 precursor [Homo sapiens] 439 e-123
gi|13994190 frizzled 8 [Homo sapiens] 338 6e-93
gi|8393378 frizzled 3 [Homo sapiens] 323 2e-88
gi|34734079 frizzled 6 [Homo sapiens] 315 7e-86
gi|5032099 smoothened [Homo sapiens] 172 9e-43
gi|48475052 secreted frizzled-related protein 2 precursor [Homo ... 106 5e-23
gi|170784838 secreted frizzled-related protein 4 [Homo sapiens] 105 1e-22
gi|29244926 corin [Homo sapiens] 104 2e-22
gi|38455388 frizzled-related protein [Homo sapiens] 104 2e-22
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens] 102 9e-22
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens] 99 7e-21
gi|13899255 membrane frizzled-related protein [Homo sapiens] 67 3e-11
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens] 57 4e-08
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] 53 6e-07
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho... 39 0.009
gi|74048357 G protein-coupled receptor 126 alpha 1 precursor [Ho... 34 0.39
gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Hom... 34 0.39
gi|74048422 G protein-coupled receptor 126 alpha 2 precursor [Ho... 34 0.39
gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Hom... 34 0.39
gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens] 33 0.50
gi|74271834 G protein-coupled receptor 155 isoform 10 [Homo sapi... 33 0.50
gi|27735127 solute carrier family 35, member F3 [Homo sapiens] 33 0.66
gi|52353953 olfactory receptor, family 2, subfamily AG, member 2... 33 0.86
gi|45433552 G protein-coupled receptor 133 [Homo sapiens] 32 1.9
>gi|22547161 frizzled 4 [Homo sapiens]
Length = 537
Score = 1111 bits (2874), Expect = 0.0
Identities = 537/537 (100%), Positives = 537/537 (100%)
Query: 1 MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNV 60
MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNV
Sbjct: 1 MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNV 60
Query: 61 TKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGM 120
TKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGM
Sbjct: 61 TKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGM 120
Query: 121 CLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEE 180
CLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEE
Sbjct: 121 CLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEE 180
Query: 181 CHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLT 240
CHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLT
Sbjct: 181 CHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLT 240
Query: 241 FLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNT 300
FLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNT
Sbjct: 241 FLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNT 300
Query: 301 GCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTI 360
GCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTI
Sbjct: 301 GCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTI 360
Query: 361 VILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNL 420
VILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNL
Sbjct: 361 VILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNL 420
Query: 421 QKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLK 480
QKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLK
Sbjct: 421 QKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLK 480
Query: 481 IFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV 537
IFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV
Sbjct: 481 IFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV 537
>gi|4503835 frizzled 9 [Homo sapiens]
Length = 591
Score = 552 bits (1423), Expect = e-157
Identities = 275/542 (50%), Positives = 362/542 (66%), Gaps = 47/542 (8%)
Query: 23 LLLQLLLLLGPARGFG--DEEERR----CDPIRISMCQNLGYNVTKMPNLVGHELQTDAE 76
LL QLL G A G D E R C + I MC+ +GYN+T+MPNL+GH Q +A
Sbjct: 11 LLWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAA 70
Query: 77 LQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFG 136
+L F PL+QYGC S L+FFLCS+Y PMCT++++ PI C MC + RC P++++F
Sbjct: 71 AELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFN 130
Query: 137 FAWPESLNCSKFPPQNDHNHMCMEGP-----GDEE----------VPLPHKTPIQPGEEC 181
F WP+SL+C++ P +ND + +CME P G E P P + P G
Sbjct: 131 FGWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGA 190
Query: 182 HSVGT--NSDQYIWVKRSLNCVLKCGYDAGLY-SRSAKEFTDIWMAVWASLCFISTAFTV 238
GT N +++ +V++S +C +CG ++ SR K+F +WMAVW++LCF STAFTV
Sbjct: 191 GGSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTV 250
Query: 239 LTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLK 298
LTFL++ RF YPERPIIFLSMCYN+YS+A+++R G + ++CD +EA +IQEGL+
Sbjct: 251 LTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACD-QEAGALYVIQEGLE 309
Query: 299 NTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVK 358
NTGC ++FLL+Y+FGMASS+WWV+LTLTWFLAAG KWGHEAIE H SYFH+AAW +PA+K
Sbjct: 310 NTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALK 369
Query: 359 TIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRS 418
TIVIL +R V DELTGLCYV + + ALTGFV+ PL YLV+G+ F+ G VALF IR
Sbjct: 370 TIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRK 429
Query: 419 NLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDS------ 472
++ GT T+KLE+LMVKIGVFS+LYTVPATCVI CY YE N +R A +
Sbjct: 430 IMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAA 489
Query: 473 ----------------NMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGK 516
+AV MLKIFMSL+VGITSG+W+WS+KT TWQ R + +G+
Sbjct: 490 GPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKIAAGR 549
Query: 517 VK 518
+
Sbjct: 550 AR 551
>gi|6005762 frizzled 10 [Homo sapiens]
Length = 581
Score = 552 bits (1422), Expect = e-157
Identities = 276/515 (53%), Positives = 360/515 (69%), Gaps = 41/515 (7%)
Query: 44 RCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYV 103
+C PI I MC+++GYN+T+MPNL+GHE Q +A +QL F PL++YGC L+FFLCS+Y
Sbjct: 33 KCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYA 92
Query: 104 PMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGP- 162
PMCTE+++ PI C MC + +C P++++F F WP+SL+C K P +ND N++CME P
Sbjct: 93 PMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPN 152
Query: 163 -GDEEV--------PL-----PHKT---PIQPGEECHSVGTNSDQYIWVKRSLNCVLKCG 205
G +E PL PH P++ G N ++ V++S +C C
Sbjct: 153 NGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCT 212
Query: 206 YDAGLY-SRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNI 264
+Y SR K F +W+A+WA LCF S+AFTVLTFLID +RF YPERPIIFLSMCY +
Sbjct: 213 PGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCV 272
Query: 265 YSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILT 324
YS+ Y++RL G E I+CD ++ + +IQEGL++TGC ++FL++Y+FGMASS+WWV+LT
Sbjct: 273 YSVGYLIRLFAGAESIACD-RDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLT 331
Query: 325 LTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNL 384
LTWFLAAG KWGHEAIE +SSYFH+AAWAIPAVKTI+IL+MR V DELTG+CYVG+ ++
Sbjct: 332 LTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDV 391
Query: 385 DALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLY 444
+ALTGFV+ PL YLVIGT FI +G VALF IR ++ G TDKLE+LMV+IG+FSVLY
Sbjct: 392 NALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLY 451
Query: 445 TVPATCVIACYFYEISNWALFRYSADD------------------SNMAVE--MLKIFMS 484
TVPATCVIACYFYE N ++ A S AVE M+KIFM
Sbjct: 452 TVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFML 511
Query: 485 LLVGITSGMWIWSAKTLHTWQK-CSNRLVNSGKVK 518
L+VGITSGMWIW++KTL +WQ+ CS RL + K
Sbjct: 512 LVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRK 546
>gi|4503827 frizzled 2 [Homo sapiens]
Length = 565
Score = 456 bits (1173), Expect = e-128
Identities = 253/552 (45%), Positives = 332/552 (60%), Gaps = 63/552 (11%)
Query: 23 LLLQLLLL--LGPARGFGDE-----EERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDA 75
LLL LLLL GPA+ G++ + C PI I +C ++ YN T MPNL+GH Q DA
Sbjct: 10 LLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDA 69
Query: 76 ELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEF 135
L++ F PL++ CS +L+FFLCS+Y P+CT + I PC +C ++ CE ++ +F
Sbjct: 70 GLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LEQAIPPCRSICERARQGCEALMNKF 128
Query: 136 GFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSD------ 189
GF WPE L C FP + ++ P T PG + + GT
Sbjct: 129 GFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGA 188
Query: 190 --QYIWVKRSLNC--VLK--------------CGYDAG--------LYSRSAKEFTDIWM 223
+Y ++ +C VLK C +S+ F +W+
Sbjct: 189 PPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWI 248
Query: 224 AVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCD 283
W+ LC ST FTV T+L+D RF YPERPIIFLS CY + S+AYI + +ER+ C+
Sbjct: 249 LTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVL-QERVVCN 307
Query: 284 --FEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIE 341
F E ++Q G K GC I+F+++YFF MASSIWWVIL+LTWFLAAG+KWGHEAIE
Sbjct: 308 ERFSEDGYRTVVQ-GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIE 366
Query: 342 MHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVI 401
+S YFH+AAWA+PAVKTI IL M +D D L+G+C+VG +LD L GFV+APLF YL I
Sbjct: 367 ANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFI 426
Query: 402 GTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEIS- 460
GT F+ AG V+LF+IR+ ++ DGTKT+KLERLMV+IGVFSVLYTVPAT VIACYFYE +
Sbjct: 427 GTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAF 486
Query: 461 --NWALFRYSADDSNMA----------------VEMLKIFMSLLVGITSGMWIWSAKTLH 502
+W S ++A V M+K M+L+VGITSG WIWS KTLH
Sbjct: 487 REHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLH 546
Query: 503 TWQKCSNRLVNS 514
+W+K RL NS
Sbjct: 547 SWRKFYTRLTNS 558
>gi|4503825 frizzled 1 [Homo sapiens]
Length = 647
Score = 446 bits (1147), Expect = e-125
Identities = 238/537 (44%), Positives = 318/537 (59%), Gaps = 59/537 (10%)
Query: 35 RGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQL 94
RG + C PI I +C ++ YN T MPNL+GH Q DA L++ F PL++ CS++L
Sbjct: 106 RGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAEL 165
Query: 95 QFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDH 154
+FFLCS+Y P+CT + + PC +C ++ CE ++ +FGF WP++L C KFP
Sbjct: 166 KFFLCSMYAPVCTV-LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAG 224
Query: 155 NHMCMEGPGDEEVPLPHKTPI------QPGEECHSVGTNSDQYIWVKRSLNC--VLK--- 203
+ D+ P P P Q G H G + +C LK
Sbjct: 225 ELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPS 284
Query: 204 -----------CG--------YDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLID 244
CG Y + F+ W+ +W+ LC ST FTVLT+L+D
Sbjct: 285 YLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVD 344
Query: 245 SSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPV-LIQEGLKNTGCA 303
RFSYPERPIIFLS CY ++AYI + +R+ C+ + A + + +G K GC
Sbjct: 345 MRRFSYPERPIIFLSGCYTAVAVAYIAGFLL-EDRVVCNDKFAEDGARTVAQGTKKEGCT 403
Query: 304 IIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVIL 363
I+F+++YFF MASSIWWVIL+LTWFLAAG+KWGHEAIE +S YFH+AAWA+PA+KTI IL
Sbjct: 404 ILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITIL 463
Query: 364 IMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKD 423
+ VD D L+G+C+VG N+DAL GFV+APLF YL IGT F+ AG V+LF+IR+ ++ D
Sbjct: 464 ALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHD 523
Query: 424 GTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEIS-------NWALFR---------- 466
GTKT+KLE+LMV+IGVFSVLYTVPAT VIACYFYE + +W
Sbjct: 524 GTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPH 583
Query: 467 ---------YSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNS 514
+ + V M+K M+L+VGITSG WIWS KTL++W+K RL NS
Sbjct: 584 LQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNS 640
>gi|4503833 frizzled 7 [Homo sapiens]
Length = 574
Score = 439 bits (1130), Expect = e-123
Identities = 246/572 (43%), Positives = 330/572 (57%), Gaps = 72/572 (12%)
Query: 11 PGAPGGVGLSLGLLLQLLLLLGPA------------RGFGDEEERRCDPIRISMCQNLGY 58
PGA + SLGL +L LLG +G + C PI I +C ++ Y
Sbjct: 4 PGAAAPLS-SLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAY 62
Query: 59 NVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCG 118
N T +PNL+GH Q DA L++ F PL++ CS +L+FFLCS+Y P+CT ++ I PC
Sbjct: 63 NQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPPCR 121
Query: 119 GMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCME--------GPGDEEVPLP 170
+C ++ CE ++ +FGF WPE L C FP +C+ GPG P
Sbjct: 122 SLCERARQGCEALMNKFGFQWPERLRCENFPVHGA-GEICVGQNTSDGSGGPGGGPTAYP 180
Query: 171 HK--------TPIQPGEECHSVGTNSDQYIW-VKRSLNCVLKCGY------DAGL----- 210
T + PG S G + + R L GY D G
Sbjct: 181 TAPYLPDLPFTALPPGA---SDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPG 237
Query: 211 -------YSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYN 263
+ + F +W+ VW+ LC ST FTVLT+L+D RFSYPERPIIFLS CY
Sbjct: 238 RANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYF 297
Query: 264 IYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVIL 323
+ ++A++ + + + + +G K GC I+F+++YFFGMASSIWWVIL
Sbjct: 298 MVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVIL 357
Query: 324 TLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQN 383
+LTWFLAAG+KWGHEAIE +S YFH+AAWA+PAVKTI IL M VD D L+G+CYVG +
Sbjct: 358 SLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSS 417
Query: 384 LDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVL 443
+DAL GFV+APLF YL IGT F+ AG V+LF+IR+ ++ DGTKT+KLE+LMV+IGVFSVL
Sbjct: 418 VDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVL 477
Query: 444 YTVPATCVIACYFYEIS-------NWAL------------FRYSADDSNMAVEMLKIFMS 484
YTVPAT V+ACYFYE + W L + + V M+K M+
Sbjct: 478 YTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMT 537
Query: 485 LLVGITSGMWIWSAKTLHTWQKCSNRLVNSGK 516
++VGIT+G WIWS KTL +W++ +RL +S K
Sbjct: 538 MIVGITTGFWIWSGKTLQSWRRFYHRLSHSSK 569
>gi|27894385 frizzled 5 precursor [Homo sapiens]
Length = 585
Score = 439 bits (1129), Expect = e-123
Identities = 237/549 (43%), Positives = 326/549 (59%), Gaps = 67/549 (12%)
Query: 11 PGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHE 70
P AP + LLL L L+G R + C I + MC+ +GYN+T MPN H+
Sbjct: 6 PSAPPSL-----LLLLLAQLVG--RAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHD 58
Query: 71 LQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEP 130
Q +A L++ F PL++ CS L+FFLCS+Y P+C + P+ PC +C K C P
Sbjct: 59 TQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSP 118
Query: 131 VLKEFGFAWPESLNCSKFPP-QNDHNHMCMEGPGDEEVPLPHKT-PIQP----------- 177
+++++GFAWPE ++C + P D +CM+ E P + P +P
Sbjct: 119 LMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPAS 178
Query: 178 GEECHSVG---------------TNSDQYIWVKRSL--NCVLKCGYDAGLYSRSAKEFTD 220
G EC + G + Y V+ NC + C + +S + F
Sbjct: 179 GGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPS--FSADERTFAT 236
Query: 221 IWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERI 280
W+ +W+ LCFIST+ TV TFLID RF YPERPIIFLS CY S+ ++VRL VG +
Sbjct: 237 FWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASV 296
Query: 281 SCDFE------EAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLK 334
+C E E P L C I+FLL+YFFGMASSIWWVIL+LTWFLAAG+K
Sbjct: 297 ACSREHNHIHYETTGPAL---------CTIVFLLVYFFGMASSIWWVILSLTWFLAAGMK 347
Query: 335 WGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAP 394
WG+EAI ++ YFH+AAW IP+VK+I L + VD D + G+CYVGNQNL++L GFV+ P
Sbjct: 348 WGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGP 407
Query: 395 LFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIAC 454
L YL++GTLF+ AG V+LF+IRS +++ GTKTDKLE+LM++IG+F++LYTVPA+ V+AC
Sbjct: 408 LVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVAC 467
Query: 455 YFYE---ISNWALFRYSADDSNMA----------VEMLKIFMSLLVGITSGMWIWSAKTL 501
Y YE +W A + V MLK FM L+VGITSG+WIWS KT+
Sbjct: 468 YLYEQHYRESWEAALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTV 527
Query: 502 HTWQKCSNR 510
+W++ ++R
Sbjct: 528 ESWRRFTSR 536
>gi|13994190 frizzled 8 [Homo sapiens]
Length = 694
Score = 338 bits (868), Expect = 6e-93
Identities = 192/430 (44%), Positives = 251/430 (58%), Gaps = 60/430 (13%)
Query: 161 GPGDEEVPLPHKTPIQPGEECHS--VGTNSDQYIWVKRS-----LNCVLKCGYDAGLYSR 213
G G P P +PG +C + V +S+++ R NC L C +S+
Sbjct: 214 GGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNP--FFSQ 271
Query: 214 SAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRL 273
+ FT W+ +W+ LCF+ST TV TFLID RF YPERPIIFLS CY S+ Y+VRL
Sbjct: 272 DERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRL 331
Query: 274 TVGRERISC----------------------------------DFEE--AAEPVLIQEGL 297
G E+++C ++EE A E + E
Sbjct: 332 VAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRYETT 391
Query: 298 KNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAV 357
C ++FLL+YFFGMASSIWWVIL+LTWFLAAG+KWG+EAI +S YFH+AAW +P+V
Sbjct: 392 GPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSV 451
Query: 358 KTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIR 417
K+I +L + VD D + G+CYVGNQ+LD L GFV+APL YL IGT+F+ AG V+LF+IR
Sbjct: 452 KSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIR 511
Query: 418 SNL-QKDG-TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISN---WA--------- 463
S + Q+DG TKT KLE+LM+++G+F+VLYTVPA V+AC FYE N W
Sbjct: 512 SVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLR 571
Query: 464 -LFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKR 522
L A + AV MLK FM L+VGITSG+W+WS KTL +W+ R + K
Sbjct: 572 DLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRSLCTRCCWASKGAAVGG 631
Query: 523 GNGWVKPGKG 532
G G G G
Sbjct: 632 GAGATAAGGG 641
Score = 123 bits (308), Expect = 5e-28
Identities = 55/147 (37%), Positives = 85/147 (57%), Gaps = 2/147 (1%)
Query: 16 GVGLSLGLLLQLLLLLGPARGFG--DEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQT 73
G L + LL L LL + G +E C I + +C+ +GYN T MPN H+ Q
Sbjct: 4 GYLLEVTSLLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQD 63
Query: 74 DAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLK 133
+A L++ F PL++ CS L+FFLCS+Y P+C E P+ PC +C K C P+++
Sbjct: 64 EAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMR 123
Query: 134 EFGFAWPESLNCSKFPPQNDHNHMCME 160
++GFAWP+ + C + P Q + + +CM+
Sbjct: 124 QYGFAWPDRMRCDRLPEQGNPDTLCMD 150
>gi|8393378 frizzled 3 [Homo sapiens]
Length = 666
Score = 323 bits (829), Expect = 2e-88
Identities = 177/496 (35%), Positives = 264/496 (53%), Gaps = 52/496 (10%)
Query: 45 CDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVP 104
C+PI + MCQ+L YN T MPNL+ H Q A L + F P++ CS + FLC++Y P
Sbjct: 28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87
Query: 105 MCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGD 164
+C E + + PC +C C +++ FG WPE + CS+FP D
Sbjct: 88 ICMEYGRVTL-PCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP--------------D 132
Query: 165 EEVPLPHKTPIQ-PGE--ECHSVGTNSDQYIWVKRSLNCVLKCGYD-----------AGL 210
+ P P + GE E V D W R L GY +
Sbjct: 133 CDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNM 192
Query: 211 YSRSAK-EFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAY 269
Y R + F ++ + + +C +T FT LTFLID +RF YPERPIIF ++CY + S+ +
Sbjct: 193 YFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIF 252
Query: 270 IVRLTVGRERISCDFEEAAE--PVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTW 327
+ + +R++C+ A+ + +G N C ++F+++YFF MA S+WWVILT+TW
Sbjct: 253 FIGFLL-EDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITW 311
Query: 328 FLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDAL 387
FLAA KWG EAIE + FH +AW IP TI++L M ++ D ++G+C+VG ++DAL
Sbjct: 312 FLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDAL 371
Query: 388 TGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVP 447
FV+APL Y+V+G + AG+++L ++R + + DKL + M++IGVFS+LY VP
Sbjct: 372 RYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVP 431
Query: 448 ATCVIACYFYE-------ISNWALFR------------YSADDSNMAVEMLKIFMSLLVG 488
VI CYFYE + W R ++ + ++K M+L+VG
Sbjct: 432 LLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVG 491
Query: 489 ITSGMWIWSAKTLHTW 504
I S W+ S KT W
Sbjct: 492 IPSVFWVGSKKTCFEW 507
>gi|34734079 frizzled 6 [Homo sapiens]
Length = 706
Score = 315 bits (807), Expect = 7e-86
Identities = 178/495 (35%), Positives = 261/495 (52%), Gaps = 50/495 (10%)
Query: 45 CDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVP 104
C+PI + C + YN+T PNL+GH Q+ A +++ F PL CS ++ FLC +VP
Sbjct: 24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83
Query: 105 MCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGD 164
C E+I++ + PC +C V C+ ++ FG WPE L C D C D
Sbjct: 84 TCIEQIHV-VPPCRKLCEKVYSDCKKLIDTFGIRWPEELEC-------DRLQYC-----D 130
Query: 165 EEVPL---PHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYD-----------AGL 210
E VP+ PH + P ++ V D W R L GY +
Sbjct: 131 ETVPVTFDPHTEFLGPQKKTEQV--QRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNM 188
Query: 211 YSRSAK-EFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAY 269
Y +S + EF ++ + C +T FT LTFLID RF YPERPII+ S+CY+I S+ Y
Sbjct: 189 YFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMY 248
Query: 270 IVRLTVGRERISCDFEEAAE-PVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWF 328
+ +G +E E + G +N C ++F+L+YFF MA ++WWVILT+TWF
Sbjct: 249 FIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWF 308
Query: 329 LAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALT 388
LAAG KW EAIE + +FH AW P T+++L M V+ D ++G+C+VG +LDA
Sbjct: 309 LAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASR 368
Query: 389 GFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPA 448
FV+ PL + +G + AG+++L +R +Q DG +KL++ M++IGVFS LY VP
Sbjct: 369 YFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPL 428
Query: 449 TCVIACYFYEISN---WAL-------------FRYSADDS---NMAVEMLKIFMSLLVGI 489
++ CY YE N W + Y A +A+ M+K M+L+VGI
Sbjct: 429 VTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKYLMTLIVGI 488
Query: 490 TSGMWIWSAKTLHTW 504
++ W+ S KT W
Sbjct: 489 SAVFWVGSKKTCTEW 503
>gi|5032099 smoothened [Homo sapiens]
Length = 787
Score = 172 bits (435), Expect = 9e-43
Identities = 133/523 (25%), Positives = 240/523 (45%), Gaps = 71/523 (13%)
Query: 45 CDPIRISMCQN--LGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYG-CSSQLQFFLCSV 101
C+P+R ++C L Y T + Q +A +L ++ L C + +Q LC+V
Sbjct: 70 CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAV 129
Query: 102 YVPMC-TEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCS--KFPP--QNDHNH 156
Y+P C +++ +P +C + + C V +E G WP+ L C+ +FP N+ +
Sbjct: 130 YMPKCENDRVELPSRT---LCQATRGPCAIVERERG--WPDFLRCTPDRFPEGCTNEVQN 184
Query: 157 MCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAK 216
+ G EVPL V T++ + W + C ++C L++ +
Sbjct: 185 IKFNSSGQCEVPL--------------VRTDNPKS-WYEDVEGCGIQC--QNPLFTEAEH 227
Query: 217 EFTDIWMAVWASLCFISTAFTVLTFLIDSSRFS-YPERPIIFLSMCYNIYSIAYIVRLTV 275
+ ++A + ++ + T FT+ TF+ D + YP + +++ C+ + SI ++ +
Sbjct: 228 QDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMD 287
Query: 276 G-RERISCDFEEAAEPVLIQEGLKNT--GCAIIFLLMYFFGMASSIWWVILTLTWFLA-A 331
G R I C A + + E N C IIF+++Y+ MA +W+V+LT W +
Sbjct: 288 GARREIVC---RADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFK 344
Query: 332 GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFV 391
L ++ + +SYFH+ W++P V T+ IL + VD D ++G+C+VG +N GFV
Sbjct: 345 ALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFV 404
Query: 392 VAPLFTYLVIGTLFIAAGLVALFKIRSNLQ--KDGTKTDKLERLMVKIGVFSVLYTVPAT 449
+AP+ L++G F+ G++ LF I+SN K+ M+++G+F L
Sbjct: 405 LAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVL 464
Query: 450 CVIACYFYEISNWALFRYSADD--------------------------SNMAVEMLKIFM 483
+C+FY+ N A + S D ++ VE + +F
Sbjct: 465 ITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFA 524
Query: 484 SLLVGITSGMWIWSAKTLHTWQKCSNRLVNSG-----KVKREK 521
GI W+W+ TL W++ RL ++K+ K
Sbjct: 525 MFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSK 567
>gi|48475052 secreted frizzled-related protein 2 precursor [Homo
sapiens]
Length = 295
Score = 106 bits (265), Expect = 5e-23
Identities = 58/169 (34%), Positives = 84/169 (49%), Gaps = 13/169 (7%)
Query: 16 GVGLSLGLLLQLLLLLGPARG---FGDEE----ERRCDPI--RISMCQNLGYNVTKMPNL 66
G G L L L LG ARG FG + C PI + +C + Y ++PNL
Sbjct: 4 GPGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNL 63
Query: 67 VGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKR 126
+GHE + Q + PL+ C + FLCS++ P+C + ++ I PC +C+ VK
Sbjct: 64 LGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKD 123
Query: 127 RCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCME-GPGDEEVPLPHKTP 174
RC PV+ FGF WP+ L C +FP ND +C+ D +P + P
Sbjct: 124 RCAPVMSAFGFPWPDMLECDRFPQDND---LCIPLASSDHLLPATEEAP 169
>gi|170784838 secreted frizzled-related protein 4 [Homo sapiens]
Length = 346
Score = 105 bits (261), Expect = 1e-22
Identities = 50/130 (38%), Positives = 79/130 (60%), Gaps = 4/130 (3%)
Query: 21 LGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLT 80
L +L+ L L L A G C+ +RI MC+++ +N+T+MPN + H Q +A L +
Sbjct: 3 LSILVALCLWLHLALGVRGAP---CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIE 59
Query: 81 TFTPLIQYGCSSQLQFFLCSVYVPMCT-EKINIPIGPCGGMCLSVKRRCEPVLKEFGFAW 139
+ L+ CS+ L+FFLC++Y P+CT E ++ PI PC +C + CEP++K + +W
Sbjct: 60 QYEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSW 119
Query: 140 PESLNCSKFP 149
PESL C + P
Sbjct: 120 PESLACDELP 129
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 104 bits (260), Expect = 2e-22
Identities = 47/118 (39%), Positives = 63/118 (53%), Gaps = 2/118 (1%)
Query: 44 RCDPIRISMCQNLGYNVTKMPNLVGHELQTDAEL--QLTTFTPLIQYGCSSQLQFFLCSV 101
+C+PI + +C NL YN T PN GH Q +A + + + F L+Q C L FF C++
Sbjct: 454 QCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTI 513
Query: 102 YVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCM 159
VP C I PC +C K RCE VL G WPE +CS+FP +N N C+
Sbjct: 514 LVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCL 571
Score = 59.3 bits (142), Expect = 9e-09
Identities = 39/125 (31%), Positives = 57/125 (45%), Gaps = 6/125 (4%)
Query: 38 GDEEERR---CDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQL 94
GD+ R C I S CQ L Y+ T P L+ + E L FT L + C +
Sbjct: 129 GDQSHRNTSACMNITHSQCQMLPYHATLTP-LLSVVRNMEMEKFLKFFTYLHRLSCYQHI 187
Query: 95 QFFLCSVYVPMCTEKINIPIG--PCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQN 152
F C++ P C + G PC C + K CE VL ++WP+ L CS+F Q
Sbjct: 188 MLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQT 247
Query: 153 DHNHM 157
+ +++
Sbjct: 248 ESSNV 252
>gi|38455388 frizzled-related protein [Homo sapiens]
Length = 325
Score = 104 bits (259), Expect = 2e-22
Identities = 56/142 (39%), Positives = 83/142 (58%), Gaps = 5/142 (3%)
Query: 10 VPGAPGGVGL-SLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVG 68
V G+PGG+ L GLL L L G C+P+RI +C++L +N+TKMPN +
Sbjct: 2 VCGSPGGMLLLRAGLLALAALCLLRVPG---ARAAACEPVRIPLCKSLPWNMTKMPNHLH 58
Query: 69 HELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCT-EKINIPIGPCGGMCLSVKRR 127
H Q +A L + F L+ CS L FFLC++Y P+CT + + PI PC +C ++
Sbjct: 59 HSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQG 118
Query: 128 CEPVLKEFGFAWPESLNCSKFP 149
CEP+L ++ +WPE+L C + P
Sbjct: 119 CEPILIKYRHSWPENLACEELP 140
>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
Length = 314
Score = 102 bits (254), Expect = 9e-22
Identities = 49/133 (36%), Positives = 73/133 (54%), Gaps = 9/133 (6%)
Query: 47 PIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMC 106
P + +C N+GY +PNL+ HE + + Q +++ PL+ C + Q FLCS++ P+C
Sbjct: 62 PADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVC 121
Query: 107 TEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMC--MEGPGD 164
++ PI PC +C +V+ CEPV++ FGF WPE L C KFP +C M P
Sbjct: 122 LDR---PIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFP----EGDVCIAMTPPNA 174
Query: 165 EEVPLPHKTPIQP 177
E P T + P
Sbjct: 175 TEASKPQGTTVCP 187
>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
Length = 317
Score = 99.4 bits (246), Expect = 7e-21
Identities = 41/107 (38%), Positives = 66/107 (61%), Gaps = 3/107 (2%)
Query: 47 PIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMC 106
P + +C +GY ++PNL+ HE + + Q +++ PL+ C S Q FLCS++ P+C
Sbjct: 57 PADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVC 116
Query: 107 TEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQND 153
++ PI PC +C +V+ C P+++ +GF WPE L+C KFP ND
Sbjct: 117 LDR---PIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDND 160
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 67.4 bits (163), Expect = 3e-11
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 42 ERRCDPIRISMCQNLGYNVTKMPNL-VGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCS 100
E C+P+++ MC L YN T PN+ VG Q + L+ + L C + LC
Sbjct: 463 ELACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCG 522
Query: 101 VYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQND 153
+ VP CT + + PC +C + +C+ L G WP NC++ P D
Sbjct: 523 LLVPRCT-PLGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRLPEAAD 572
>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
Length = 641
Score = 57.0 bits (136), Expect = 4e-08
Identities = 39/140 (27%), Positives = 65/140 (46%), Gaps = 12/140 (8%)
Query: 23 LLLQLLLLLGPARGFGDEEERR----CDPIRISMCQNLGYNVTKMPNLVGHE----LQTD 74
LLL +L++ AR G E ER C +++ C + YN T PNL+ H ++
Sbjct: 7 LLLLTVLVVAAARP-GCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEAS 65
Query: 75 AE-LQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLK 133
+E + L+ L++ C+ L+ C+V P C PC +C ++ C+P
Sbjct: 66 SEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEG--GWVRRPCRHICEGLREVCQPAFD 123
Query: 134 EFGFAWPESLNCSKFPPQND 153
AWP L+C ++ + D
Sbjct: 124 AIDMAWPYFLDCHRYFTRED 143
>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
Length = 652
Score = 53.1 bits (126), Expect = 6e-07
Identities = 29/114 (25%), Positives = 52/114 (45%), Gaps = 7/114 (6%)
Query: 45 CDPIRISMCQNLGYNVTKMPNLVGHE----LQTDAE-LQLTTFTPLIQYGCSSQLQFFLC 99
C +++ C + YN T PNL+ H ++ +E + L+ L++ C+ L+ C
Sbjct: 43 CVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 102
Query: 100 SVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQND 153
+V P C PC +C ++ C+P AWP L+C ++ + D
Sbjct: 103 AVLAPRCEG--GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTRED 154
>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
sapiens]
Length = 1751
Score = 39.3 bits (90), Expect = 0.009
Identities = 34/126 (26%), Positives = 52/126 (41%), Gaps = 7/126 (5%)
Query: 44 RCDPIRISM--CQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSV 101
RC P+ S+ C +LG + +PN + HE + L+Q C L +F C +
Sbjct: 333 RCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLL 392
Query: 102 YVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEG 161
VP C PC C +++ C L G P + C+ P Q D + + G
Sbjct: 393 LVPPCGSVPPPAPPPCCQFCEALQDACWSRLG--GGRLP--VACASLPTQED-GYCVLIG 447
Query: 162 PGDEEV 167
P E +
Sbjct: 448 PAAERI 453
>gi|74048357 G protein-coupled receptor 126 alpha 1 precursor [Homo
sapiens]
Length = 1221
Score = 33.9 bits (76), Expect = 0.39
Identities = 53/248 (21%), Positives = 106/248 (42%), Gaps = 31/248 (12%)
Query: 210 LYSRSAKEFTDIWMAVWASLCFISTAFTVLTFL-IDSSRFSYPERPIIFLSMCYNIYSIA 268
L +R+ K T I + + I +A T+LT++ + R YP + ++ LS ++
Sbjct: 856 LDARNTKVLTFI-SYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLL 914
Query: 269 YIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWF 328
+++ + + +GL C + +L++FF +A+ W + + +
Sbjct: 915 FLLDGWITSFNV--------------DGL----CIAVAVLLHFFLLATFTWMGLEAIHMY 956
Query: 329 LAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALT 388
+A +K + I + F I W +PA+ V+L R + +E+ G G + D
Sbjct: 957 IAL-VKVFNTYIRRYILKFCIIGWGLPALVVSVVLASR--NNNEVYGKESYGKEKGDEFC 1013
Query: 389 GFVVAPLFTYLV----IGTLF---IAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFS 441
++ P+ Y+ G +F IA +V + +I K +T + E L V S
Sbjct: 1014 -WIQDPVIFYVTCAGYFGVMFFLNIAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVS 1072
Query: 442 VLYTVPAT 449
+ + + T
Sbjct: 1073 LTFLLGMT 1080
>gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Homo
sapiens]
Length = 1250
Score = 33.9 bits (76), Expect = 0.39
Identities = 53/248 (21%), Positives = 106/248 (42%), Gaps = 31/248 (12%)
Query: 210 LYSRSAKEFTDIWMAVWASLCFISTAFTVLTFL-IDSSRFSYPERPIIFLSMCYNIYSIA 268
L +R+ K T I + + I +A T+LT++ + R YP + ++ LS ++
Sbjct: 856 LDARNTKVLTFI-SYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLL 914
Query: 269 YIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWF 328
+++ + + +GL C + +L++FF +A+ W + + +
Sbjct: 915 FLLDGWITSFNV--------------DGL----CIAVAVLLHFFLLATFTWMGLEAIHMY 956
Query: 329 LAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALT 388
+A +K + I + F I W +PA+ V+L R + +E+ G G + D
Sbjct: 957 IAL-VKVFNTYIRRYILKFCIIGWGLPALVVSVVLASR--NNNEVYGKESYGKEKGDEFC 1013
Query: 389 GFVVAPLFTYLV----IGTLF---IAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFS 441
++ P+ Y+ G +F IA +V + +I K +T + E L V S
Sbjct: 1014 -WIQDPVIFYVTCAGYFGVMFFLNIAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVS 1072
Query: 442 VLYTVPAT 449
+ + + T
Sbjct: 1073 LTFLLGMT 1080
>gi|74048422 G protein-coupled receptor 126 alpha 2 precursor [Homo
sapiens]
Length = 1193
Score = 33.9 bits (76), Expect = 0.39
Identities = 53/248 (21%), Positives = 106/248 (42%), Gaps = 31/248 (12%)
Query: 210 LYSRSAKEFTDIWMAVWASLCFISTAFTVLTFL-IDSSRFSYPERPIIFLSMCYNIYSIA 268
L +R+ K T I + + I +A T+LT++ + R YP + ++ LS ++
Sbjct: 828 LDARNTKVLTFI-SYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLL 886
Query: 269 YIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWF 328
+++ + + +GL C + +L++FF +A+ W + + +
Sbjct: 887 FLLDGWITSFNV--------------DGL----CIAVAVLLHFFLLATFTWMGLEAIHMY 928
Query: 329 LAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALT 388
+A +K + I + F I W +PA+ V+L R + +E+ G G + D
Sbjct: 929 IAL-VKVFNTYIRRYILKFCIIGWGLPALVVSVVLASR--NNNEVYGKESYGKEKGDEFC 985
Query: 389 GFVVAPLFTYLV----IGTLF---IAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFS 441
++ P+ Y+ G +F IA +V + +I K +T + E L V S
Sbjct: 986 -WIQDPVIFYVTCAGYFGVMFFLNIAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVS 1044
Query: 442 VLYTVPAT 449
+ + + T
Sbjct: 1045 LTFLLGMT 1052
>gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Homo
sapiens]
Length = 1222
Score = 33.9 bits (76), Expect = 0.39
Identities = 53/248 (21%), Positives = 106/248 (42%), Gaps = 31/248 (12%)
Query: 210 LYSRSAKEFTDIWMAVWASLCFISTAFTVLTFL-IDSSRFSYPERPIIFLSMCYNIYSIA 268
L +R+ K T I + + I +A T+LT++ + R YP + ++ LS ++
Sbjct: 828 LDARNTKVLTFI-SYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLL 886
Query: 269 YIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWF 328
+++ + + +GL C + +L++FF +A+ W + + +
Sbjct: 887 FLLDGWITSFNV--------------DGL----CIAVAVLLHFFLLATFTWMGLEAIHMY 928
Query: 329 LAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALT 388
+A +K + I + F I W +PA+ V+L R + +E+ G G + D
Sbjct: 929 IAL-VKVFNTYIRRYILKFCIIGWGLPALVVSVVLASR--NNNEVYGKESYGKEKGDEFC 985
Query: 389 GFVVAPLFTYLV----IGTLF---IAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFS 441
++ P+ Y+ G +F IA +V + +I K +T + E L V S
Sbjct: 986 -WIQDPVIFYVTCAGYFGVMFFLNIAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVS 1044
Query: 442 VLYTVPAT 449
+ + + T
Sbjct: 1045 LTFLLGMT 1052
>gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens]
Length = 870
Score = 33.5 bits (75), Expect = 0.50
Identities = 19/84 (22%), Positives = 40/84 (47%), Gaps = 4/84 (4%)
Query: 301 GCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTI 360
G ++F+L+Y ++ +W +L ++ FL E +++ I+ W IPA+
Sbjct: 442 GQILVFVLLYSSLYSTYLWTGLLAISLFLLKK----RERVQIPVGIIIISGWGIPALLVG 497
Query: 361 VILIMRLVDADELTGLCYVGNQNL 384
V+LI + D + + G + +
Sbjct: 498 VLLITGKHNGDSIDSAFFYGKEQM 521
>gi|74271834 G protein-coupled receptor 155 isoform 10 [Homo
sapiens]
Length = 870
Score = 33.5 bits (75), Expect = 0.50
Identities = 19/84 (22%), Positives = 40/84 (47%), Gaps = 4/84 (4%)
Query: 301 GCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTI 360
G ++F+L+Y ++ +W +L ++ FL E +++ I+ W IPA+
Sbjct: 442 GQILVFVLLYSSLYSTYLWTGLLAISLFLLKK----RERVQIPVGIIIISGWGIPALLVG 497
Query: 361 VILIMRLVDADELTGLCYVGNQNL 384
V+LI + D + + G + +
Sbjct: 498 VLLITGKHNGDSIDSAFFYGKEQM 521
>gi|27735127 solute carrier family 35, member F3 [Homo sapiens]
Length = 490
Score = 33.1 bits (74), Expect = 0.66
Identities = 30/115 (26%), Positives = 53/115 (46%), Gaps = 12/115 (10%)
Query: 358 KTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAP----LFTYLVIGTLFI--AAGLV 411
K V L+ +V D G+ V + A+ G V+ ++ VIG + +A +
Sbjct: 257 KAFVFLLSWIVLRDRFMGVRIVAA--ILAIAGIVMMTYADGFHSHSVIGIALVVASASMS 314
Query: 412 ALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCV-IACYFYEISNWALF 465
AL+K+ L K + + +GVF++L+ TC+ I YF ++ W+ F
Sbjct: 315 ALYKVLFKLLLGSAKFGEAALFLSILGVFNILF---ITCIPIILYFTKVEYWSSF 366
>gi|52353953 olfactory receptor, family 2, subfamily AG, member 2
[Homo sapiens]
Length = 316
Score = 32.7 bits (73), Expect = 0.86
Identities = 21/85 (24%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 287 AAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSY 346
+AE +L+ + AI L Y M+ + W+++ +W LA+ + GH MH +
Sbjct: 109 SAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPF 168
Query: 347 FHIAAWAIPAVKTIVILIMRLVDAD 371
+W I + + +++L AD
Sbjct: 169 --CVSWEIRHLLCEIPPLLKLACAD 191
>gi|45433552 G protein-coupled receptor 133 [Homo sapiens]
Length = 874
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/128 (21%), Positives = 59/128 (46%), Gaps = 11/128 (8%)
Query: 300 TGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKT 359
T C ++ +L+++F +++ W ++ L + +G E + Y++ W P +
Sbjct: 630 TPCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSE--DSKHRYYYGMGWGFPLLIC 687
Query: 360 IVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLV-IGTLFIAAGLVALFKIRS 418
I+ L + D+ + C++ + A+ FV LF +V IG L+A+ ++ S
Sbjct: 688 IISLSFAM-DSYGTSNNCWLSLAS-GAIWAFVAPALFVIVVNIGI------LIAVTRVIS 739
Query: 419 NLQKDGTK 426
+ D K
Sbjct: 740 QISADNYK 747
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.451
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,906,309
Number of Sequences: 37866
Number of extensions: 1030003
Number of successful extensions: 3073
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2986
Number of HSP's gapped (non-prelim): 62
length of query: 537
length of database: 18,247,518
effective HSP length: 107
effective length of query: 430
effective length of database: 14,195,856
effective search space: 6104218080
effective search space used: 6104218080
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.