Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 22538387

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
         (3907 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]       7494   0.0  
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]       7472   0.0  
gi|81295809 pericentrin [Homo sapiens]                                313   3e-84
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   306   2e-82
gi|55770834 centromere protein F [Homo sapiens]                       285   8e-76
gi|109255234 centrosomal protein 290kDa [Homo sapiens]                241   1e-62
gi|71061468 centromere protein E [Homo sapiens]                       239   4e-62
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    230   2e-59
gi|21735548 centrosomal protein 2 [Homo sapiens]                      214   2e-54
gi|148746195 trichohyalin [Homo sapiens]                              199   3e-50
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       191   9e-48
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       191   9e-48
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        191   9e-48
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        191   9e-48
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        191   9e-48
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        191   9e-48
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        191   9e-48
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        191   9e-48
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...   182   6e-45
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]    179   6e-44
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               171   1e-41
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   167   2e-40
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   167   2e-40
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   166   4e-40
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        164   2e-39
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            162   8e-39
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   159   4e-38
gi|148536869 ninein isoform 2 [Homo sapiens]                          157   1e-37
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   157   3e-37
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   157   3e-37

>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 7494 bits (19445), Expect = 0.0
 Identities = 3907/3907 (100%), Positives = 3907/3907 (100%)

Query: 1    MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
            MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS
Sbjct: 1    MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60

Query: 61   QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
            QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG
Sbjct: 61   QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120

Query: 121  CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180
            CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE
Sbjct: 121  CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180

Query: 181  MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240
            MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI
Sbjct: 181  MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240

Query: 241  QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300
            QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF
Sbjct: 241  QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300

Query: 301  LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
            LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG
Sbjct: 301  LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360

Query: 361  ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420
            ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ
Sbjct: 361  ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420

Query: 421  RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
            RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN
Sbjct: 421  RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480

Query: 481  ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
            ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS
Sbjct: 481  ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540

Query: 541  REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600
            REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL
Sbjct: 541  REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600

Query: 601  EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
            EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG
Sbjct: 601  EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660

Query: 661  IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720
            IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ
Sbjct: 661  IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720

Query: 721  INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780
            INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL
Sbjct: 721  INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780

Query: 781  KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840
            KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN
Sbjct: 781  KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840

Query: 841  EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
            EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL
Sbjct: 841  EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900

Query: 901  HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
            HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS
Sbjct: 901  HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960

Query: 961  DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020
            DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL
Sbjct: 961  DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020

Query: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080
            DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK
Sbjct: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080

Query: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
            ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD
Sbjct: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140

Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200
            KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS
Sbjct: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200

Query: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260
            YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL
Sbjct: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260

Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
            NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN
Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320

Query: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380
            HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV
Sbjct: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380

Query: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440
            PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL
Sbjct: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440

Query: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500
            EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF
Sbjct: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500

Query: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560
            QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI
Sbjct: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560

Query: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620
            VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR
Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620

Query: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
            EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN
Sbjct: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680

Query: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
            SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK
Sbjct: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740

Query: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800
            TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800

Query: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860
            SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA
Sbjct: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860

Query: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920
            ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920

Query: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
            EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980

Query: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
            EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL
Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040

Query: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
            EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100

Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160
            QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL
Sbjct: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160

Query: 2161 LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2220
            LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE
Sbjct: 2161 LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2220

Query: 2221 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2280
            NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF
Sbjct: 2221 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2280

Query: 2281 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2340
            GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC
Sbjct: 2281 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2340

Query: 2341 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400
            VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ
Sbjct: 2341 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400

Query: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460
            QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK
Sbjct: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460

Query: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
            DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK
Sbjct: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520

Query: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2580
            QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE
Sbjct: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2580

Query: 2581 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2640
            PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE
Sbjct: 2581 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2640

Query: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700
            KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA
Sbjct: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700

Query: 2701 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760
            TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE
Sbjct: 2701 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760

Query: 2761 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI 2820
            SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI
Sbjct: 2761 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI 2820

Query: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880
            ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS
Sbjct: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880

Query: 2881 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP 2940
            KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP
Sbjct: 2881 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP 2940

Query: 2941 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 3000
            KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK
Sbjct: 2941 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 3000

Query: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060
            MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL
Sbjct: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060

Query: 3061 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE 3120
            LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE
Sbjct: 3061 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE 3120

Query: 3121 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3180
            LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK
Sbjct: 3121 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3180

Query: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240
            AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE
Sbjct: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240

Query: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300
            ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV
Sbjct: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300

Query: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3360
            LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV
Sbjct: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3360

Query: 3361 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3420
            ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE
Sbjct: 3361 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3420

Query: 3421 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3480
            EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW
Sbjct: 3421 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3480

Query: 3481 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE 3540
            VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE
Sbjct: 3481 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE 3540

Query: 3541 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS 3600
            TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS
Sbjct: 3541 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS 3600

Query: 3601 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL 3660
            QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL
Sbjct: 3601 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL 3660

Query: 3661 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK 3720
            TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK
Sbjct: 3661 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK 3720

Query: 3721 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF 3780
            YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF
Sbjct: 3721 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF 3780

Query: 3781 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI 3840
            LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI
Sbjct: 3781 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI 3840

Query: 3841 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3900
            RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ
Sbjct: 3841 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3900

Query: 3901 FHAGMRR 3907
            FHAGMRR
Sbjct: 3901 FHAGMRR 3907


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 7472 bits (19387), Expect = 0.0
 Identities = 3899/3907 (99%), Positives = 3899/3907 (99%), Gaps = 8/3907 (0%)

Query: 1    MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
            MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS
Sbjct: 1    MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60

Query: 61   QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
            QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG
Sbjct: 61   QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120

Query: 121  CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180
            CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE
Sbjct: 121  CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180

Query: 181  MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240
            MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI
Sbjct: 181  MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240

Query: 241  QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300
            QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF
Sbjct: 241  QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300

Query: 301  LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
            LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG
Sbjct: 301  LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360

Query: 361  ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420
            ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ
Sbjct: 361  ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420

Query: 421  RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
            RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN
Sbjct: 421  RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480

Query: 481  ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
            ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS
Sbjct: 481  ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540

Query: 541  REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600
            REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL
Sbjct: 541  REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600

Query: 601  EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
            EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG
Sbjct: 601  EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660

Query: 661  IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720
            IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ
Sbjct: 661  IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720

Query: 721  INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780
            INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL
Sbjct: 721  INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780

Query: 781  KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840
            KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN
Sbjct: 781  KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840

Query: 841  EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
            EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL
Sbjct: 841  EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900

Query: 901  HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
            HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS
Sbjct: 901  HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960

Query: 961  DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020
            DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL
Sbjct: 961  DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020

Query: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080
            DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK
Sbjct: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080

Query: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
            ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD
Sbjct: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140

Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200
            KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS
Sbjct: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200

Query: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260
            YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL
Sbjct: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260

Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
            NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN
Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320

Query: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380
            HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV
Sbjct: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380

Query: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440
            PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL
Sbjct: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440

Query: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500
            EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF
Sbjct: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500

Query: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560
            QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI
Sbjct: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560

Query: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620
            VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR
Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620

Query: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
            EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN
Sbjct: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680

Query: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
            SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK
Sbjct: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740

Query: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800
            TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800

Query: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860
            SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA
Sbjct: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860

Query: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920
            ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920

Query: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
            EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980

Query: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
            EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL
Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040

Query: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
            EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100

Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160
            QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL
Sbjct: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160

Query: 2161 LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2220
            L        VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE
Sbjct: 2161 L--------VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2212

Query: 2221 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2280
            NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF
Sbjct: 2213 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2272

Query: 2281 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2340
            GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC
Sbjct: 2273 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2332

Query: 2341 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400
            VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ
Sbjct: 2333 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2392

Query: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460
            QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK
Sbjct: 2393 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2452

Query: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
            DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK
Sbjct: 2453 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2512

Query: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2580
            QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE
Sbjct: 2513 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2572

Query: 2581 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2640
            PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE
Sbjct: 2573 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2632

Query: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700
            KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA
Sbjct: 2633 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2692

Query: 2701 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760
            TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE
Sbjct: 2693 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2752

Query: 2761 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI 2820
            SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI
Sbjct: 2753 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI 2812

Query: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880
            ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS
Sbjct: 2813 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2872

Query: 2881 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP 2940
            KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP
Sbjct: 2873 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP 2932

Query: 2941 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 3000
            KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK
Sbjct: 2933 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 2992

Query: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060
            MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL
Sbjct: 2993 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3052

Query: 3061 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE 3120
            LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE
Sbjct: 3053 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE 3112

Query: 3121 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3180
            LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK
Sbjct: 3113 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3172

Query: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240
            AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE
Sbjct: 3173 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3232

Query: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300
            ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV
Sbjct: 3233 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3292

Query: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3360
            LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV
Sbjct: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3352

Query: 3361 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3420
            ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE
Sbjct: 3353 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3412

Query: 3421 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3480
            EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW
Sbjct: 3413 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3472

Query: 3481 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE 3540
            VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE
Sbjct: 3473 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE 3532

Query: 3541 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS 3600
            TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS
Sbjct: 3533 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS 3592

Query: 3601 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL 3660
            QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL
Sbjct: 3593 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL 3652

Query: 3661 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK 3720
            TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK
Sbjct: 3653 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK 3712

Query: 3721 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF 3780
            YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF
Sbjct: 3713 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF 3772

Query: 3781 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI 3840
            LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI
Sbjct: 3773 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI 3832

Query: 3841 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3900
            RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ
Sbjct: 3833 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3892

Query: 3901 FHAGMRR 3907
            FHAGMRR
Sbjct: 3893 FHAGMRR 3899


>gi|81295809 pericentrin [Homo sapiens]
          Length = 3336

 Score =  313 bits (801), Expect = 3e-84
 Identities = 430/1880 (22%), Positives = 794/1880 (42%), Gaps = 311/1880 (16%)

Query: 656  KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI---LEISK---LKDLQQSL 709
            +D  G+H  Q + GL+      +E ++    N+ T Q +L    L+  K   L +L++ L
Sbjct: 231  EDEAGLHQSQAVHGLE------LEALRLSLSNMHTAQLELTQANLQKEKETALTELREML 284

Query: 710  VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769
             + +++E+ L  +  Q E+E+LR++        +E +E+ L+      ++KEK     EK
Sbjct: 285  NSRRAQELALLQSRQQHELELLREQHA------REKEEVVLRCGQEAAELKEKLQSEMEK 338

Query: 770  FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEE- 828
             AQ+           KTL++         + E+ + L++++ K   +  + E+E L  + 
Sbjct: 339  NAQIV----------KTLKEDW-------ESEKDLCLENLR-KELSAKHQSEMEDLQNQF 380

Query: 829  NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK--QE 886
             ++L +Q  +L E+I + +N    A +N E ++Q      A + K+++DL+    +  ++
Sbjct: 381  QKELAEQRAEL-EKIFQDKNQAERALRNLESHHQ------AAIEKLREDLQSEHGRCLED 433

Query: 887  LEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
            LE+K K     ++L L+ +  +   +K+   +E +   ++ L+      ++ +EL E+L 
Sbjct: 434  LEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQ-LDSARTSRQELSELHEQL- 491

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRA 1006
                  L  + R+ DL EQLKQ+                EK Q      +L I       
Sbjct: 492  ------LARTSRVEDL-EQLKQR----------------EKTQHESELEQLRIYFEKKLR 528

Query: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
            +  ++    +        T+  +  +G+          E  ++  D V      VG E K
Sbjct: 529  DAEKTYQEDL--------TLLQQRLQGA---------REDALL--DSVEVGLSCVGLEEK 569

Query: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126
             E+   DH+  +  E    +       + Q EL      +   R Q+EA    L + +  
Sbjct: 570  PEKGRKDHVDELEPERHKESLP-----RFQAEL------EESHRHQLEALESPLCIQHEG 618

Query: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
            HV               C ++   +    E   E  + H  EL  +  Q   D       
Sbjct: 619  HVSD------------RCCVETSAL--GHEWRLEPSEGHSQELPWVHLQGVQD------- 657

Query: 1187 LIGKLQKAVSEECSYF-LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245
              G L+           L+T   V        LK E+     EN   Y     +  L+D 
Sbjct: 658  --GDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKD- 714

Query: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG---------EEN 1296
                 D ++  H L+    +E N              Q+T+ MK EF          +E 
Sbjct: 715  -----DLEKVKHNLIEDHQKELNNAK-----------QKTELMKQEFQRKETDWKVMKEE 758

Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEE-------QVQELESLISS 1349
            L +E  E L++   +  L +   + K  + +  +L + ++ +       Q+ +LE  ++ 
Sbjct: 759  LQREAEEKLTL--MLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTE 816

Query: 1350 LQQQLKETEQNYEAE--IHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGS-CV 1406
             Q +L++ EQ+  ++  +HC Q       E        + ++ + E  A + M   S  +
Sbjct: 817  QQGRLQQLEQDLTSDDALHCSQ----CGREPPTAQDGELAALHVKEDCALQLMLARSRFL 872

Query: 1407 KKNIDGTIEFSGEFGV------KEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTE 1460
            ++  + T +FS E         ++    ++LL++++Q+QL      + V+  +    Q  
Sbjct: 873  EERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQL------LSVTAELEARHQAA 926

Query: 1461 LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKE 1520
            L  ++   E+   +  A  V + +  +  ++   + +    + ++++  +  EF+ + +E
Sbjct: 927  LGELTASLESKQGALLAARVAELQTKHAADLGALETR-HLSSLDSLESCYLSEFQTIREE 985

Query: 1521 LGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQL 1580
               H + + L  +D               E+++ KD       S+H  I    ++  ++ 
Sbjct: 986  ---HRQALELLRAD-------------FEEQLWKKD-------SLHQTILTQELEKLKRK 1022

Query: 1581 MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR 1640
              +E +L+ +R  L  +       T       + Q E   E +  L E+ + L  Q AQ 
Sbjct: 1023 --HEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQA 1080

Query: 1641 SSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTF 1700
                 E    E+E + L+  +   Q+     + L         +++     Q    E   
Sbjct: 1081 QPFHQE----EKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENRE 1136

Query: 1701 KEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
                L     DV   +  +ER ALQ A  RLL +  E ++    +   IG  V   LD +
Sbjct: 1137 GANLLSMLKADV--NLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDA 1194

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820
                          A  ++ +    E T  +D ++P     D   ++    S V E    
Sbjct: 1195 G-------------AGLALSTAPALEETW-SDVALPEL---DRTLSECAEMSSVAE---- 1233

Query: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880
            +S  +  S     E   E E+ +  +   L  AV+ L+E   ++S QLE A+   +   +
Sbjct: 1234 ISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEK 1293

Query: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQE 1940
            E   + +E  + ++  +EL E L EES A+ +LA+EL K +G ++G+  E    +  +  
Sbjct: 1294 EFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAG 1353

Query: 1941 KTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEK 2000
            K D   RL  EL     +LQ+   EQ  ++EE   L  + EA   +A   E  L +E E 
Sbjct: 1354 KEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVED 1413

Query: 2001 LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEK 2060
            L KE+ E + QAEK R  L  Q+K LE ++EEQ+S+     ++    +  L QQ  +L+K
Sbjct: 1414 LTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEA-VTALEQQVASLDK 1472

Query: 2061 QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTR------EVEQL 2114
             L   R+F+DEQA +REHER+ FQQEIQ+LE QL+   + QP     ++      EVE L
Sbjct: 1473 HLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELL 1532

Query: 2115 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFR---------------------V 2153
               L+EK D+ +EL + KE   R +  + EEI++LE                       V
Sbjct: 1533 QQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIV 1592

Query: 2154 RELEQ----------ALLVSADTFQKVEDRKHF-GAVEAKPELSLEVQLQAERDAIDRKE 2202
            + LEQ          + L+ A T Q   D           P    E+QL+  + A+ R+E
Sbjct: 1593 KGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRE 1652

Query: 2203 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK------D 2256
             E+ +L+EQLE+ + +LE+KNEE+  L+++L++Q  ++   L+ELE+EN   K       
Sbjct: 1653 SEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSS 1712

Query: 2257 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI------ 2310
            ++E+L   I+       + Q           +EK  EI+QL+E + KLQ +L +      
Sbjct: 1713 EIEELKATIENLQENQKRLQ-----------KEKAEEIEQLHEVIEKLQHELSLMGPVVH 1761

Query: 2311 -TTDNKVIEEKNELI---------RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2360
              +D++    ++EL+         + L+ ++E  +  +E + R   ++  + ++ +E LQ
Sbjct: 1762 EVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQ 1821

Query: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2420
            Q L    +   +       +   L+  + +  AE   +  +++     +   +  + E N
Sbjct: 1822 QRLQGAEEAAEL-------QLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874

Query: 2421 FKMNQLTQELFSLKRERESV 2440
             +++ L Q   +   E E+V
Sbjct: 1875 LEIDALNQRKAAHSAELEAV 1894



 Score =  307 bits (787), Expect = 1e-82
 Identities = 290/1017 (28%), Positives = 496/1017 (48%), Gaps = 134/1017 (13%)

Query: 2940 PKKIKGLLRAVHNEGMQVLSLTE--SPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDL 2997
            PK +K LL+ V +E  Q+L+L+E  +P S GE H  ++  E               ++D+
Sbjct: 2389 PKHVKALLQMVRDESHQILALSEGLAPPS-GEPHPPRKEDE---------------IQDI 2432

Query: 2998 ITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDA 3057
                   +E           +  DWRG+LL  +Q+ F +E+ +     +  L+       
Sbjct: 2433 SLHGGKTQEVPT--------ACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGH 2484

Query: 3058 VGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM------NGRKITLKR- 3110
              LL  LE+ I+EQG   + ++E L+  DR SLLSEIQAL AQ+      N  K+   R 
Sbjct: 2485 SSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRT 2544

Query: 3111 ----------EQESEKPSQ-ELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKM 3159
                      +QE +   Q ELL Y ++Q++    ++Q  LS  +++A  +Q+ L++E+ 
Sbjct: 2545 ALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQT 2604

Query: 3160 VVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRE 3219
            VV +LKS+L +++ + E   ++  +  +E+   R  +  K +E+      L SEQ K R 
Sbjct: 2605 VVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRA 2664

Query: 3220 LQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES 3279
            LQ  LE+E+ +  + E +  + LE+L+ SLE+Q+ ++ +L + L+ ++   +  Q+++  
Sbjct: 2665 LQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRI 2724

Query: 3280 QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPL 3339
            +    +A L++E+ +  ELQ  L +EK R  E+S  L  ER L  QL  S  T ++    
Sbjct: 2725 EHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL--SQRTQEACVHQ 2782

Query: 3340 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3399
             ++     LQK  EEK SR+V+L    EK +  +L ++QQ+E + Q H + L+ E+E + 
Sbjct: 2783 DTQAHHALLQKLKEEK-SRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSA 2841

Query: 3400 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE--EKRESR 3457
              +  +  L ++  +L+  LE +R++   L  E ++    ++E + ++  R   E R+S 
Sbjct: 2842 TLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSP 2901

Query: 3458 RILYQNLNEPTTWSLTSDRTRNWVLQQ-----KIEG--------ETKESNYAKLIEM--- 3501
                Q       W    ++ R   LQ+     KI+         E+K+      + +   
Sbjct: 2902 AAAEQ----WRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSA 2957

Query: 3502 -NGGGTGCNH------ELEMIRQKLQCVASKLQVLPQKASERL--QFETADDEDFIWVQE 3552
                G+  +H      ELE +RQ+L   A  L     +A +R    + +++++  + +  
Sbjct: 2958 RRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017

Query: 3553 NIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNM 3612
             ++E+   L + T  Q +  + +          + LL+ N  LT  +S +T+EK +L   
Sbjct: 3018 TLEELKSDLSRPTSSQKKMAAELQ-----FQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072

Query: 3613 VMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAE 3672
            V KLE+ ++ + Q G                      SE+  W  ++   Q SL+R +  
Sbjct: 3073 VSKLEKLLKHHLQKGCSPSR-----------------SERSAWKPDETAPQSSLRRPDPG 3115

Query: 3673 VYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQEC 3732
              +L      ++        + +V ++++Y  YLRAESFRKALIYQKKYLLLL+GGFQ+ 
Sbjct: 3116 --RLPPAASEEA-------HTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDS 3166

Query: 3733 EDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSV 3792
            E  TL+++A +G  P+  + + IT+RP  FTRFR+AVRV IAI R++FLV++W  V    
Sbjct: 3167 EQETLSMIAHLGVFPSKAERK-ITSRP--FTRFRTAVRVVIAILRLRFLVKKWQEV---- 3219

Query: 3793 SININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNR--- 3849
                +R G  L QG              +    PR        D+    +  P + R   
Sbjct: 3220 ----DRKG-ALAQGKAPRP----GPRARQPQSPPRTRESPPTRDVPSGHTRDPARGRRLA 3270

Query: 3850 -----YPGTPADFNPGS-LACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3900
                 + G  A  +P S L  S   + DP+ +LT+YI  LE +Q+RLG +   ST++
Sbjct: 3271 AAASPHSGGRATPSPNSRLERSLTASQDPEHSLTEYIHHLEVIQQRLGGVLPDSTSK 3327



 Score =  145 bits (367), Expect = 6e-34
 Identities = 381/1780 (21%), Positives = 698/1780 (39%), Gaps = 250/1780 (14%)

Query: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGF---AGTEIDP-----ENEEL 1842
            T E    ++ SD P     M++K  E+  EL+   + SG    AG          E E L
Sbjct: 191  TPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250

Query: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ-EATESLKCQEELRE 1901
             L++S+   A +E        T + L+  K T    +RE    ++ +    L+ +++   
Sbjct: 251  RLSLSNMHTAQLEL-------TQANLQKEKETALTELREMLNSRRAQELALLQSRQQHEL 303

Query: 1902 RLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL-----LCAS 1956
             L  E  ARE+  V L   +      A+ K   + ++++   I+  L+++      LC  
Sbjct: 304  ELLREQHAREKEEVVLRCGQEA----AELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLE 359

Query: 1957 NRLQELEAEQQQIQEE-RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKV 2015
            N  +EL A+ Q   E+ +    ++    +AE   + Q   Q    L   +   Q   EK+
Sbjct: 360  NLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419

Query: 2016 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075
            R+DLQ +      D+E    +F E E+EK  EL +L+   + L+ Q ++  + L  Q   
Sbjct: 420  REDLQSEHGRCLEDLE---FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDS 476

Query: 2076 REHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQL 2135
                R    QE+ +L +QL            +  ++EQL    +EKT   SEL    EQL
Sbjct: 477  ARTSR----QELSELHEQLLA-------RTSRVEDLEQLKQ--REKTQHESEL----EQL 519

Query: 2136 QRDIQERNEEIEKLEFRVRELEQALLVSA---DTFQKVEDRKHFGAVEAKPELSLEVQLQ 2192
            +   +++  + EK       L Q  L  A        VE       +E KPE       +
Sbjct: 520  RIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPE-------K 572

Query: 2193 AERDAIDRKEKEITNLEEQLEQFREELENKN-EEVQQLHMQLEIQKK-----ESTTRLQE 2246
              +D +D  E E    +E L +F+ ELE  +  +++ L   L IQ +             
Sbjct: 573  GRKDHVDELEPE--RHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSA 630

Query: 2247 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQII-QEKEVEIDQLNEQVTKLQ 2305
            L  E +L   +     L       +   D      + A+++  E E ++     Q++ LQ
Sbjct: 631  LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKV-----QLSLLQ 685

Query: 2306 QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN 2365
             +LK   +   IE +N L   L+ +   L  D E VK N          +IE  Q+EL N
Sbjct: 686  TELKEEIELLKIENRN-LYGKLQHETR-LKDDLEKVKHN----------LIEDHQKELNN 733

Query: 2366 IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ 2425
              QKT +       +    K     V+ E+L  E     A E++T M   L+E      Q
Sbjct: 734  AKQKTELMKQEFQRKETDWK-----VMKEELQRE-----AEEKLTLMLLELREKAESEKQ 783

Query: 2426 LTQELFSLKR-ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484
                 F L+  E   ++  Q+     +  ++        +LE  LT D            
Sbjct: 784  TIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREP 843

Query: 2485 SFEENGKGSIINLE----TRLLQLESTVSAKDLELTQCYKQ-----IKDMQEQGQFETEM 2535
               ++G+ + ++++     +L+   S    +  E+T+ +       +++ QEQ   E ++
Sbjct: 844  PTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQL 903

Query: 2536 LQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQ-----TISSEPERTNIQNLN 2590
            LQ++  + Q+++   V A L ++ Q  A+ E     +  Q        +E +  +  +L 
Sbjct: 904  LQER--HQQQLL--SVTAELEARHQ-AALGELTASLESKQGALLAARVAELQTKHAADLG 958

Query: 2591 QLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE--IAEKNVLEKEKKLLELQK 2648
             L    L S  S  +  +SE ++   E   +L L +   E  + +K+ L +     EL+K
Sbjct: 959  ALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEK 1018

Query: 2649 LLEGNE-KKQREKEKKRSPQDVEVLKTTT-EL-------FHSNEESGFFNELEALRAESV 2699
            L   +E + Q  ++  R+    E+  T   EL       F S +++    + E LR +S 
Sbjct: 1019 LKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSA 1078

Query: 2700 ATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQ 2759
              +     ++E+ E L  +L  K   +  L+  +  +   + E + +L +L++  E E +
Sbjct: 1079 QAQ---PFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENR 1135

Query: 2760 ESKKACMFEPLPIKLSKSIASQTDGTLK----------------ISSSNQTPQILVKNAG 2803
            E           + LS S        L+                 S   +   + + +AG
Sbjct: 1136 EGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAG 1195

Query: 2804 IQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQL 2863
              + L +  + EE    ++        + EL        E   ++E  +  RE ++    
Sbjct: 1196 AGLALSTAPALEETWSDVA--------LPELDRTLSECAEMSSVAEISSHMRESFLMSPE 1247

Query: 2864 LKEEC-GTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDS--------GSDWGQGIY 2914
               EC   ++ V Q L S     + E+A   + Q  E     S         ++    + 
Sbjct: 1248 SVRECEQPIRRVFQSL-SLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVV 1306

Query: 2915 LTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQ 2974
              H +  +   E    ++E A +    K +G L     E   +  +      +  +H + 
Sbjct: 1307 RKHQELLECLKEESAAKAELALEL--HKTQGTLEGFKVETADLKEVLAG--KEDSEHRLV 1362

Query: 2975 QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF 3034
               E    + +      ++L++  T++  + EA   D+     +      +L     +  
Sbjct: 1363 LELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETR 1422

Query: 3035 LE---ERSVLLAAFRTELTAL--------GTTDAVGLLNCLEQRI---------QEQGVE 3074
             +   +RS LL+  +   + L        G       +  LEQ++         Q Q ++
Sbjct: 1423 KQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMD 1482

Query: 3075 YQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ--------ELLEYNI 3126
             QAA    ++ +R     EIQ L  Q+   +   K +    + SQ        ELL+  +
Sbjct: 1483 EQAAE---REHEREEFQQEIQRLEGQL---RQAAKPQPWGPRDSQQAPLDGEVELLQQKL 1536

Query: 3127 QQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHL 3186
            ++K  +  E+ ++  S  DR   +QE+   E   + E+   + +   +L+  ++ Q   +
Sbjct: 1537 REKLDEFNELAIQKES-ADRQVLMQEE---EIKRLEEMNINIRKKVAQLQEEVEKQKNIV 1592

Query: 3187 KELEAFRLEVKDKTDEVHLLNDTLASEQKKSR-------------ELQWALEKEKAKLGR 3233
            K LE  +  +K +     LL  TL S     R             E+Q  + +       
Sbjct: 1593 KGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRE 1652

Query: 3234 SEERD-KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQ 3292
            SE  D KE+LE +K  LES+ +  L LNL L+ Q      S +++E +            
Sbjct: 1653 SEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEE------------ 1700

Query: 3293 GRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL 3352
              N  L+V+  +    I E+ +T++  +E   +LQ        +      + L E+ ++L
Sbjct: 1701 --NTSLKVIY-TRSSEIEELKATIENLQENQKRLQ--------KEKAEEIEQLHEVIEKL 1749

Query: 3353 EEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKV 3412
            + + S +  +++E    +  SLQ+     +      + LQ E EA  E ++ +  L +  
Sbjct: 1750 QHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA-- 1807

Query: 3413 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQ--EFQKQELER 3450
                   +++R+    L+   QRLQG  +  E Q  ELER
Sbjct: 1808 -------DQERRHSQALEALQQRLQGAEEAAELQLAELER 1840



 Score =  131 bits (329), Expect = 1e-29
 Identities = 432/2144 (20%), Positives = 856/2144 (39%), Gaps = 331/2144 (15%)

Query: 1    MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
            +E E+R++K+EAG+ KLA FR             ++K K  +S S+   +      +D S
Sbjct: 3    VEQEQRRRKVEAGRTKLAHFR-------------QRKTKGDSSHSEKKTAKRKGSAVDAS 49

Query: 61   QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
               E  +      +S +     I ++    +      G         +   +DC  E   
Sbjct: 50   VQEESPVTKE---DSALCGGGDICKSTSCDDTPDGAGG-------AFAAQPEDCDGEKRE 99

Query: 121  CSFVMRTGKPTNLLREE--EFGVDDSYSEQGAQ----DSPTHLEMM--ESELAGKQHEIE 172
                ++  +  +   E+   F V D   EQ       D P     M   S+   +QH + 
Sbjct: 100  DLEQLQQKQVNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMF 159

Query: 173  ELNRELEEMRVTYGTEGLQQLQEFEAAIK----QRDGIITQLTANLQQARREKDETMREF 228
             ++    E R  +     Q  Q     +     ++ GI T      +Q      E  +E 
Sbjct: 160  TVSDHPPEQRGMFTISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQEC 219

Query: 229  -LELT--EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE 285
             L +T  E  ++ +    Q QA   L       + +++  A+ ++     Q E++  L E
Sbjct: 220  ELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTE 279

Query: 286  DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKT 345
              +        +++ LQ +       Q  ++E   ++  +EKE ++     +  E ++K 
Sbjct: 280  LREMLNSRRAQELALLQSR-------QQHELELLREQHAREKEEVVLRCGQEAAELKEKL 332

Query: 346  LELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQ--SSEEIKQLMGTVEE 403
                +K     K L E  E   +K+  ++N++ EL+   Q E +   ++  K+L     E
Sbjct: 333  QSEMEKNAQIVKTLKEDWES--EKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAE 390

Query: 404  LQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM----------KQELI 453
            L+K     +Q E   ++ +E   Q  +E+LR +L   +G+ +  +          KQ  +
Sbjct: 391  LEKIFQDKNQAER-ALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLEL 449

Query: 454  RQHMAQMEEMKTRHKGE-------MENALRSYSNITVNEDQIKLMNVAINELNIKLQDTN 506
                A  E++K + + E       +++A  S   ++   +Q+      + +L    Q   
Sbjct: 450  ENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREK 509

Query: 507  SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ-----------TIAEQE 555
            +Q E   E+L +  E+K  L+   +   E+L+  ++++Q AR+           +    E
Sbjct: 510  TQHESELEQLRIYFEKK--LRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLE 567

Query: 556  SKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE-----KEKNAV 610
             K  +  K    V++L+ E    S  R + EL+      +++ +LE LE     + +  V
Sbjct: 568  EKPEKGRK--DHVDELEPERHKESLPRFQAELEE-----SHRHQLEALESPLCIQHEGHV 620

Query: 611  LDRMAESQEAELERLRTQLLFSHEEELSKLK----EDLEIEHRINIEKLKDNLGI--HYK 664
             DR      A     R +    H +EL  +     +D ++E   + E+    LG+   +K
Sbjct: 621  SDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLE--ADTERAARVLGLETEHK 678

Query: 665  QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
             Q+  LQ E+ ++IE ++ E  NL  K    +   ++LKD  + + ++  E+   ++N  
Sbjct: 679  VQLSLLQTELKEEIELLKIENRNLYGK----LQHETRLKDDLEKVKHNLIEDHQKELNNA 734

Query: 725  QKEIEILRQEEKEKGT----LEQEVQ-ELQLKTELLEKQMKEK-ENDLQ---EKFAQLEA 775
            +++ E+++QE + K T    +++E+Q E + K  L+  +++EK E++ Q    KF   EA
Sbjct: 735  KQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREA 794

Query: 776  ENSILKDEKKTLEDMLKIHTPVSQEE-RLIFLD-----------SIKSKSKDSVWEKEIE 823
            E   L+D++     +L +   +++++ RL  L+           S   +   +  + E+ 
Sbjct: 795  EMRQLQDQQAA--QILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELA 852

Query: 824  ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKN 883
             L  + +   Q  +  +  +E+++          +   QE QE++A  L++   L++   
Sbjct: 853  ALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQL---LQERHQ 909

Query: 884  KQELEYKSKLKALNE----ELHLQRINPTTVKMKSSVFDEDKTFVA-----ETLEMGEVV 934
            +Q L   ++L+A ++    EL     +     + + V +      A     ET  +  + 
Sbjct: 910  QQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLD 969

Query: 935  EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG-EISFLNEEVKSLKQEKEQVSLR 993
              ++  L E   + +  +  L    +D  EQL +K     + L +E++ LK++ E     
Sbjct: 970  SLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHE----- 1024

Query: 994  CRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDK 1053
              EL+ + +H R        T+VS+ L G V    +G           FG E K  + +K
Sbjct: 1025 -GELQSVRDHLR--------TEVSTELAGTVAHELQGVH------QGEFGSEKKTALHEK 1069

Query: 1054 VSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQM 1113
                  T+  +S Q Q          ++ SL      +N ++Q+    LK +   L  ++
Sbjct: 1070 ----EETLRLQSAQAQPFHQE-----EKESLSLQLQKKNHQVQQ----LKDQVLSLSHEI 1116

Query: 1114 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK---IKELQKIHQLELQ 1170
            E  R  L +     + Q RE    E    L  LK ++  +  E+      L+++  L  +
Sbjct: 1117 EECRSELEV-----LQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGE 1171

Query: 1171 TMKTQET-------------GDEGKPLHLLIGKLQKAVSEECS-YFLQTLCSVLGEYYTP 1216
            T++   T              D G  L L       A+ E  S   L  L   L E    
Sbjct: 1172 TLRAAVTLRSRIGERVGLCLDDAGAGLAL---STAPALEETWSDVALPELDRTLSECAEM 1228

Query: 1217 ALKCEVNAEDKEN---SGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVL 1273
            +   E+++  +E+   S + + E E P     R   Q     +  L+    +   +L   
Sbjct: 1229 SSVAEISSHMRESFLMSPESVRECEQP----IRRVFQSLSLAVDGLMEMALDSSRQLEEA 1284

Query: 1274 QTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK 1333
            +   S+         + EF  +N  +E  + +  H ++  LE +     +K     +L K
Sbjct: 1285 RQIHSR--------FEKEFSFKN--EETAQVVRKHQEL--LECLKEESAAKAELALELHK 1332

Query: 1334 TKLEEQVQELESL-ISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVIT 1392
            T+   +  ++E+  +  +    +++E     E+  L+++LQ  ++               
Sbjct: 1333 TQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQ--------------- 1377

Query: 1393 ESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452
            E  A R        +     T   + E  +++E   +   + + ++Q E++ + ++  M 
Sbjct: 1378 EQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMK 1437

Query: 1453 IAFAQ-QTELSRISG-GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKF 1510
            I  ++ + +LS+  G  K+  A +     V   ++H  N+ +   +Q   +  E  +  F
Sbjct: 1438 ILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREE--F 1495

Query: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS 1570
            ++E + L  +L +  K       D    P   +  L + +++  K   F       +E++
Sbjct: 1496 QQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVEL-LQQKLREKLDEF-------NELA 1547

Query: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630
            +    A RQ+++ EE+++ + +  +                        R+   QLQEE+
Sbjct: 1548 IQKESADRQVLMQEEEIKRLEEMNI----------------------NIRKKVAQLQEEV 1585

Query: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSL-AGREKLCCELRNSSTQTQNGN 1689
            ++  + + +    D E L  ++   LL  L +  Q +L AGR   C E  + S     G 
Sbjct: 1586 EK-QKNIVKGLEQDKEVLKKQQMSSLL--LASTLQSTLDAGR---CPEPPSGS--PPEGP 1637

Query: 1690 ENQGEVEEQTFKEKE---LDRKPEDVPPEILSNERYALQKANNRL--LKILLEVVKTTAA 1744
            E Q EV ++    +E   LD K      E L   +  L+  N  +  L + L++  +  A
Sbjct: 1638 EIQLEVTQRALLRRESEVLDLK------EQLEKMKGDLESKNEEILHLNLKLDMQNSQTA 1691

Query: 1745 VE----ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPS--- 1797
            V     E     +  I  RSS+ +         E +A++++ + E   R+  E       
Sbjct: 1692 VSLRELEEENTSLKVIYTRSSEIE---------ELKATIEN-LQENQKRLQKEKAEEIEQ 1741

Query: 1798 -YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEI-DPENEELMLNISSRLQAAVE 1855
             +   +  ++++++   V  E ++     ++S    ++   P  + L   + + L+A   
Sbjct: 1742 LHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAK-- 1799

Query: 1856 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915
               EA+S   +  E       E +++  +  +EA E    + E    L E     E +A 
Sbjct: 1800 ---EALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAE--VEDMAS 1854

Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
             + + E  +   A E T+ ER ++     ID L Q     S    ELEA    +   R  
Sbjct: 1855 RIQEFEAALK--AKEATIAERNLE-----IDALNQRKAAHS---AELEAVLLALARIRRA 1904

Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV------QCQAE 2013
            L +Q   + A A P E Q L+     +  +L+V      +CQ E
Sbjct: 1905 LEQQ--PLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVE 1946



 Score =  114 bits (286), Expect = 1e-24
 Identities = 356/1734 (20%), Positives = 692/1734 (39%), Gaps = 266/1734 (15%)

Query: 2103 ISEHQTREVEQL-ANHLKEKTDKCSEL--LLSKEQLQRD--IQERNE-EIEKL-EFRVRE 2155
            +S   T ++E   AN  KEK    +EL  +L+  + Q    +Q R + E+E L E   RE
Sbjct: 254  LSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHARE 313

Query: 2156 LEQALL----VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERD-AIDRKEKEIT---- 2206
             E+ +L     +A+  +K++      A   K   +L+   ++E+D  ++   KE++    
Sbjct: 314  KEEVVLRCGQEAAELKEKLQSEMEKNAQIVK---TLKEDWESEKDLCLENLRKELSAKHQ 370

Query: 2207 -NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
              +E+   QF++EL  +  E++++       K ++   L+ LE  ++     +EKL   +
Sbjct: 371  SEMEDLQNQFQKELAEQRAELEKIFQD----KNQAERALRNLESHHQAA---IEKLREDL 423

Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN-----------EQVTKLQQQL-KITTD 2313
            +       +D   L  KF +  +EK++E++ L            E++ +L  QL    T 
Sbjct: 424  QSEHGRCLED---LEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS 480

Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQK--TS 2371
             + + E +E +    +++E L   ++  K   E E+EQL    EK  ++     Q+  T 
Sbjct: 481  RQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTL 540

Query: 2372 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELF 2431
            +         D+L   ++V ++  + LE++ E   ++              +++L  E  
Sbjct: 541  LQQRLQGAREDALLDSVEVGLS-CVGLEEKPEKGRKD-------------HVDELEPE-- 584

Query: 2432 SLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGK 2491
               R +ES+ + Q+  E S    ++ L             D      +    +   E  +
Sbjct: 585  ---RHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSE 641

Query: 2492 GSIINLETRLLQLESTVSAKDLEL-TQCYKQIKDMQEQGQFETEMLQ---KKIVNLQKIV 2547
            G    L    LQ    V   DLE  T+   ++  ++ + + +  +LQ   K+ + L KI 
Sbjct: 642  GHSQELPWVHLQ---GVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIE 698

Query: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2607
               +   L  + +L+   E  K    N     + E  N +   +L + E     +   + 
Sbjct: 699  NRNLYGKLQHETRLKDDLEKVKH---NLIEDHQKELNNAKQKTELMKQEFQRKETDWKVM 755

Query: 2608 ISELESQVVEMHTSLILE-KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSP 2666
              EL+ +  E  T ++LE +E+ E  ++ ++ K           E  E + R+ + +++ 
Sbjct: 756  KEELQREAEEKLTLMLLELREKAESEKQTIINK----------FELREAEMRQLQDQQAA 805

Query: 2667 QDVEVLKTTTELFHSNEESGFFNELE-------ALRAESVATKAELASYKEKAEKLQEEL 2719
            Q +++ ++ TE      + G   +LE       AL       +   A   E A      L
Sbjct: 806  QILDLERSLTE------QQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA-----L 854

Query: 2720 LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE--DETEVQESKKACMFEPLPIKLSKS 2777
             VKE     L    S+  +   E  EK S  +     E + Q +++  + +    +   S
Sbjct: 855  HVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLS 914

Query: 2778 IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAA 2837
            + ++ +   + +    T  +  K        Q    +  V E+ ++    +  ++  H +
Sbjct: 915  VTAELEARHQAALGELTASLESK--------QGALLAARVAELQTKHAADLGALETRHLS 966

Query: 2838 EILDMESRHISETETLKREHYVAVQLLK----EECGTLKAVIQCLRSKEGSSIPELAHSD 2893
             +  +ES ++SE +T++ EH  A++LL+    E+     ++ Q + ++E   +      +
Sbjct: 967  SLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGE 1026

Query: 2894 AYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIK---GLLRAV 2950
                R+   ++  ++   G      QG  +     G E ++A     + ++      +  
Sbjct: 1027 LQSVRDHLRTEVSTELA-GTVAHELQG--VHQGEFGSEKKTALHEKEETLRLQSAQAQPF 1083

Query: 2951 HNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVY 3010
            H E  + LSL        ++H +QQ+ +  L    +  + I   +  +  +Q +RE E  
Sbjct: 1084 HQEEKESLSL----QLQKKNHQVQQLKDQVL----SLSHEIEECRSELEVLQQRRERENR 1135

Query: 3011 DSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTT------------DAV 3058
            + +            +L A   +   ER  L  A R  L   G T            + V
Sbjct: 1136 EGANLL--------SMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERV 1187

Query: 3059 GLLNCLEQRIQEQGVEYQAAME------CLQKADRR----SLLSEIQALHAQM-NGRKIT 3107
            GL  CL+       +    A+E       L + DR     + +S +  + + M     ++
Sbjct: 1188 GL--CLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMS 1245

Query: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3167
             +  +E E+P + + + ++      ++EM ++ S   + A ++  +   E     E  ++
Sbjct: 1246 PESVRECEQPIRRVFQ-SLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQ 1304

Query: 3168 LAQTKLELETTLKAQ-----------HKHLKELEAFRLEVKD-------KTDEVHLL--- 3206
            + +   EL   LK +           HK    LE F++E  D       K D  H L   
Sbjct: 1305 VVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLE 1364

Query: 3207 NDTLASEQKKSRELQWALEKEKAKL---GRSEERDKE--------ELEDL-KFSLESQKQ 3254
             ++L  + +++ + Q AL +E  +L   G +   D E        E+EDL K   E++KQ
Sbjct: 1365 LESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQ 1424

Query: 3255 RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVL-----LESEKVRI 3309
                 + LL Q K L +E ++++   R         E    LE QV      L +++  +
Sbjct: 1425 AEKDRSALLSQMKILESELEEQLSQHR---GCAKQAEAVTALEQQVASLDKHLRNQRQFM 1481

Query: 3310 REMSSTLDRER-ELHAQLQSSDG----TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLN 3364
             E ++  + ER E   ++Q  +G      + +P  P +     L  ++E    ++ E L+
Sbjct: 1482 DEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLD 1541

Query: 3365 ETEKYKLDSLQTRQQMEKDRQV--HRKTLQTEQEANTEGQKKMHELQSKVE---DLQRQL 3419
            E  +  +      Q+   DRQV    + ++  +E N   +KK+ +LQ +VE   ++ + L
Sbjct: 1542 EFNELAI------QKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGL 1595

Query: 3420 EE-----KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTS 3474
            E+     K+QQ+  L L    LQ  +   +  E       E   I      E T  +L  
Sbjct: 1596 EQDKEVLKKQQMSSL-LLASTLQSTLDAGRCPEPPSGSPPEGPEIQL----EVTQRALLR 1650

Query: 3475 DRTRNWVLQQKIE---GETKESNYAKL-----IEMNGGGTGCN-HELEMIRQKLQCV--- 3522
              +    L++++E   G+ +  N   L     ++M    T  +  ELE     L+ +   
Sbjct: 1651 RESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTR 1710

Query: 3523 ASKLQVLP------QKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVS 3576
            +S+++ L       Q+  +RLQ E A++       E + E+I +LQ      G     VS
Sbjct: 1711 SSEIEELKATIENLQENQKRLQKEKAEE------IEQLHEVIEKLQHELSLMGPVVHEVS 1764

Query: 3577 PSTSCGSLTERLLRQNA------ELTGHISQLTEEKNDLRNMVMKLE----EQIRWYRQT 3626
             S   GSL   LL   A       L G +    E K  L  ++   E    + +   +Q 
Sbjct: 1765 DS-QAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQR 1823

Query: 3627 GAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL 3680
              G + ++   L       A+  +E E         + +LK  EA + +   E+
Sbjct: 1824 LQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEI 1877



 Score = 97.8 bits (242), Expect = 2e-19
 Identities = 350/1837 (19%), Positives = 718/1837 (39%), Gaps = 313/1837 (17%)

Query: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQ--LMLNEEQ-LEDMRQELV 1595
            PE +  + TIS+    +   F        E++++ +++ R+    L++ Q +  +  E +
Sbjct: 192  PEQRG-IFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250

Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
            R    +    +L     + Q   Q+E +  L E  + LN + AQ  +     L+  R++ 
Sbjct: 251  RLSLSNMHTAQL----ELTQANLQKEKETALTELREMLNSRRAQELA-----LLQSRQQ- 300

Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK------EKELDRKP 1709
               ELE L++     +E++       + + +   +++ E   Q  K      E E D   
Sbjct: 301  --HELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCL 358

Query: 1710 EDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASL 1769
            E++  E+ +  +  ++   N+  K   E+ +  A +E+                      
Sbjct: 359  ENLRKELSAKHQSEMEDLQNQFQK---ELAEQRAELEKIFQD------------------ 397

Query: 1770 IWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSG 1829
              +++AE ++++   E H +   E +         R D+          +E  + L    
Sbjct: 398  --KNQAERALRNL--ESHHQAAIEKL---------REDLQ---------SEHGRCLEDLE 435

Query: 1830 FAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL--MRESFRQKQ 1887
            F   E + E +  + N+ +  +    +  E I    SQL+ A+ ++ EL  + E    + 
Sbjct: 436  FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLART 495

Query: 1888 EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTD--II 1945
               E L+ Q + RE+   ES   +       K       Y ++ TL ++++Q   +  ++
Sbjct: 496  SRVEDLE-QLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALL 554

Query: 1946 DRLEQELLCAS----------NRLQELEAEQQQ-----IQEERELLSR-QKEAMKA---- 1985
            D +E  L C            + + ELE E+ +      Q E E   R Q EA+++    
Sbjct: 555  DSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCI 614

Query: 1986 -EAGPVEQQLLQETEKLMKE-KLE-----------VQCQAEKVRD---DLQKQVKALEID 2029
               G V  +   ET  L  E +LE           V  Q  +  D   D ++  + L ++
Sbjct: 615  QHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLE 674

Query: 2030 VEEQVS---------RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE----QAIDR 2076
             E +V            IEL + +N  L    Q    L+  LEK++  L E    +  + 
Sbjct: 675  TEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNA 734

Query: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ----LANHLKEKTDKCSELLLSK 2132
            + + ++ +QE Q+ E   KV+       E   RE E+    +   L+EK +   + +++K
Sbjct: 735  KQKTELMKQEFQRKETDWKVM------KEELQREAEEKLTLMLLELREKAESEKQTIINK 788

Query: 2133 EQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVE------DRKH----------- 2175
             +L+    E  +  ++   ++ +LE++L       Q++E      D  H           
Sbjct: 789  FELRE--AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTA 846

Query: 2176 ----FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHM 2231
                  A+  K + +L++ L   R   +RKE  IT      E+F  E +   +E Q+ H 
Sbjct: 847  QDGELAALHVKEDCALQLMLARSRFLEERKE--IT------EKFSAEQDAFLQEAQEQHA 898

Query: 2232 QLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2291
            + E+Q  +   + Q L    +L       LG   + + ++ ++   +L  + A++  +  
Sbjct: 899  R-ELQLLQERHQQQLLSVTAELEARHQAALG---ELTASLESKQGALLAARVAELQTKHA 954

Query: 2292 VEIDQLNEQVTKLQQQLK--ITTDNKVIEEKN----ELIR-DLETQI--------ECLMS 2336
             ++  L  +       L+    ++ + I E++    EL+R D E Q+          L  
Sbjct: 955  ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014

Query: 2337 DQECVKRNREEEIEQLNEVIE-KLQQELANI----------GQKTSMNAHSLSEEADSLK 2385
            + E +KR  E E++ + + +  ++  ELA            G+  S    +L E+ ++L+
Sbjct: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074

Query: 2386 HQLDVVIA----EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL--KRERES 2439
             Q          EK +L  Q++  N ++  +K+ +   + ++ +   EL  L  +RERE+
Sbjct: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134

Query: 2440 VEKIQSIPENSVNVAIDHLSKDKPEL----------EVVLTEDALKSLENQTYFKSFEEN 2489
             E    +     +V + H  +   +           E +     L+S   +      ++ 
Sbjct: 1135 REGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDA 1194

Query: 2490 GKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKI--- 2546
            G G  ++    L +  S V+  +L+ T    +  +M    +  + M +  +++ + +   
Sbjct: 1195 GAGLALSTAPALEETWSDVALPELDRT--LSECAEMSSVAEISSHMRESFLMSPESVREC 1252

Query: 2547 --------------VEEKVAAALVSQIQLE-AVQEYAKFCQDNQTISSEPE---RTNIQN 2588
                          V+  +  AL S  QLE A Q +++F ++    + E     R + + 
Sbjct: 1253 EQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQEL 1312

Query: 2589 LNQLREDELGSDISALTLRISELESQVVEMHTSLILE----KEQVEIAEKNVLEKEKKLL 2644
            L  L+E+       AL L  ++   +  ++ T+ + E    KE  E   + VLE E    
Sbjct: 1313 LECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSE--HRLVLELESLRR 1370

Query: 2645 ELQKLLE-------------------GNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES 2685
            +LQ+  +                     + + RE   ++  +D+   ++ T      + S
Sbjct: 1371 QLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRS 1430

Query: 2686 GFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKE 2745
               ++++ L +E      E  S      K  E +   E  + SL K L   R  + E   
Sbjct: 1431 ALLSQMKILESEL----EEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAA 1486

Query: 2746 KLSILEKEDETEVQ--ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAG 2803
            +     +E + E+Q  E +     +P P     S  +  DG +++       ++   N  
Sbjct: 1487 EREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFN-- 1544

Query: 2804 IQINLQSECSSEEVTEIISQFTEKIEKMQELH------AAEILDMESRHISETETLKREH 2857
             ++ +Q E +  +V        E+I++++E++       A++ +   +  +  + L+++ 
Sbjct: 1545 -ELAIQKESADRQVL----MQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDK 1599

Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTH 2917
             V   L K++  +L        + +    PE       +  EI    +     + +    
Sbjct: 1600 EV---LKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQ----RALLRRE 1652

Query: 2918 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS 2977
            S+  D+  +   E+ +   +S  ++I  L   +  +  Q          +     +    
Sbjct: 1653 SEVLDLKEQL--EKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTR 1710

Query: 2978 EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEE 3037
               +EE KA   TI +L++   ++Q ++  E+    Q HE     + EL L +  V  E 
Sbjct: 1711 SSEIEELKA---TIENLQENQKRLQKEKAEEI---EQLHEVIEKLQHELSL-MGPVVHEV 1763

Query: 3038 RSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQAL 3097
                  + ++EL     + A G       R Q    E +AA+E  +   R  LL++ +  
Sbjct: 1764 SDSQAGSLQSELLC---SQAGG------PRGQALQGELEAALEAKEALSR--LLADQERR 1812

Query: 3098 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3157
            H+Q       L+  Q+  + ++E  E  + + +  +   + E+  M  R  E +  L ++
Sbjct: 1813 HSQ------ALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAK 1866

Query: 3158 KMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3194
            +  +AE         LE++   + +  H  ELEA  L
Sbjct: 1867 EATIAE-------RNLEIDALNQRKAAHSAELEAVLL 1896



 Score = 92.8 bits (229), Expect = 6e-18
 Identities = 130/623 (20%), Positives = 264/623 (42%), Gaps = 68/623 (10%)

Query: 244  QLQASETLRNSTHSSTAADLLQAKQQI-LTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
            Q ++ E LR    SS  +++   + Q+ +TH Q  E+  HL       +   + Q   L+
Sbjct: 2502 QEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLR 2561

Query: 303  EKIKV--YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
             ++++  Y++EQ+K +    ++ + E++     +   +  E+    +LK  L  + +   
Sbjct: 2562 RQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621

Query: 361  ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420
            +L   + +  QE+  ++  L++ + + + + +E++   G    LQ      SQ E + ++
Sbjct: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQ------SQLEEEQLR 2675

Query: 421  RMEQETQ--RKLEQLRAELDEMYGQQ---IVQMKQE--------------------LIRQ 455
             +++E+Q  + LE+LRA L+    Q     V +K E                    L+ Q
Sbjct: 2676 HLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQ 2735

Query: 456  HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK---EKL 512
              +Q+ E++     E    L     +       + ++    E  +  QDT +     +KL
Sbjct: 2736 ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVH-QDTQAHHALLQKL 2794

Query: 513  KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL-STVEDL 571
            KEE   +++    LQ  LE + ++   S++Q++   Q   E   +  E   +L STVE L
Sbjct: 2795 KEEKSRVVD----LQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEAL 2850

Query: 572  ---KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ 628
               K E+  + E  +E     +AE+     +L+  E  K A     A    A  E+ R  
Sbjct: 2851 HTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWR-- 2908

Query: 629  LLFSHEEELSKLKEDLEIEHRINIEKLKD----NLGIHYKQQIDGLQNEMSQKIETMQFE 684
                 + +  KL+E LE++ + ++ K+K        +  K ++ G +  +         +
Sbjct: 2909 ---KWQRDKEKLRE-LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSD 2964

Query: 685  KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744
             D+L  +Q +L     +L    + L +  S+ +   +N+           EK   +L   
Sbjct: 2965 ADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTS------SNEKAVMSLLHT 3018

Query: 745  VQELQLKTELLEKQMKEKENDLQEKFAQ--LEAENSILKDEKKTLEDMLKIHTPVSQEER 802
            ++EL+          K+   +LQ +F    L+   S+ K      ++ L++   VS+ E+
Sbjct: 3019 LEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK 3078

Query: 803  LIFLDSIK----SKSKDSVWEKE 821
            L+     K    S+S+ S W+ +
Sbjct: 3079 LLKHHLQKGCSPSRSERSAWKPD 3101



 Score = 83.6 bits (205), Expect = 4e-15
 Identities = 148/669 (22%), Positives = 283/669 (42%), Gaps = 100/669 (14%)

Query: 324  IQEKETIIEELNTKIIEEEKKTLELKDK---LTTADKLLGELQEQIVQKNQEIKNMKLEL 380
            ++  E II E    + E+  + L L D+   L+    L  +L+   +Q  +++++++  L
Sbjct: 2488 LERLEKIIREQGD-LQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTAL 2546

Query: 381  TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440
            T++   E + S++  QL   VE L  +  ++     D+ + + +E Q K   +       
Sbjct: 2547 TSA---EARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEE-QEKANSV------- 2595

Query: 441  YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK-LMNVAINELN 499
              Q+++  +Q ++R   + + E + +     E   RS   +     Q++ +++   NEL 
Sbjct: 2596 --QKLLAAEQTVVRDLKSDLCESRQKS----EQLSRSLCEVQQEVLQLRSMLSSKENELK 2649

Query: 500  IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559
              LQ+  S++ K +           ALQ QLE+  E+L   + + Q A+     + S   
Sbjct: 2650 AALQELESEQGKGR-----------ALQSQLEE--EQLRHLQRESQSAKALEELRASLET 2696

Query: 560  EAHKSLSTVEDLKAEIVSASESRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAE 616
            +  +S      LK E  +    +KEL ++H   EA +   + +L  L+K+  A   R  E
Sbjct: 2697 QRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLE 2756

Query: 617  SQEA-ELERLRTQLLFSHEEE-------------LSKLKEDLE--IEHRINIEKLKDNLG 660
              EA   ERL T+ L    +E             L KLKE+    ++ +  +EK++    
Sbjct: 2757 LSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQ-A 2815

Query: 661  IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720
            +H +QQ++    E  +  E ++ EK+   T ++ +    ++ ++L+ SL   + +   LQ
Sbjct: 2816 LHSQQQLEA---EAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQ 2872

Query: 721  INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780
                Q    +  QE ++      E ++     E   K  ++KE  L+E   Q + +   +
Sbjct: 2873 AELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEK-LRELELQRQRDLHKI 2931

Query: 781  KDEKKTLEDM-LKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQL 839
            K  ++T+ D+  K   P S   RL    + ++   D+   +E +    E E ++Q+ +  
Sbjct: 2932 KQLQQTVRDLESKDEVPGS---RLHLGSARRAAGSDADHLREQQ---RELEAMRQRLLSA 2985

Query: 840  NEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEE 899
                   R   SF  +  +              +  +D   S  K  +     L+ L  +
Sbjct: 2986 ------ARLLTSFTSQAVD--------------RTVNDWTSSNEKAVMSLLHTLEELKSD 3025

Query: 900  LHLQRINPTTVKMKSSVFDEDKTFVAET-LEMGEVVEKDTTELMEKLEVTKREKLELSQR 958
            L      PT+           K   AE   +  +V+ KD   L + L    +EKLELS+ 
Sbjct: 3026 LS----RPTS---------SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072

Query: 959  LSDLSEQLK 967
            +S L + LK
Sbjct: 3073 VSKLEKLLK 3081



 Score = 75.5 bits (184), Expect = 1e-12
 Identities = 89/426 (20%), Positives = 176/426 (41%), Gaps = 38/426 (8%)

Query: 1838 ENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE 1897
            E ++ +L + S L +   +L  A+ E  S+    +  Q++L  E  R  Q  ++S K  E
Sbjct: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688

Query: 1898 ELRERLHEESRAREQLAVELSKAEGVIDGYADEKTL----FERQIQEKTDIIDRLEQELL 1953
            ELR  L  +     +L V L   +   D    E  +     E  + ++   +  L+++L 
Sbjct: 2689 ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLA 2748

Query: 1954 CASNRLQEL-EAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA 2012
               +R  EL EA + +     +L  R +EA   +       LLQ+ ++     +++Q   
Sbjct: 2749 AEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAML 2808

Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQ 2072
            EKV+       + LE + ++       L +EK      L+   +AL  Q  ++R      
Sbjct: 2809 EKVQQQALHSQQQLEAEAQKHCE---ALRREKEVS-ATLKSTVEALHTQKRELR-----C 2859

Query: 2073 AIDREHERDVF-QQEIQKLEQQLK-----------VVPRFQPISEHQTREVEQLANHLKE 2120
            +++RE E+  + Q E+++   +LK              R  P +  Q R+ ++    L+E
Sbjct: 2860 SLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRE 2919

Query: 2121 KTDKCSELLLSKEQLQRDIQ--ERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGA 2178
               +    L   +QLQ+ ++  E  +E+      +    +A    AD  +  E ++   A
Sbjct: 2920 LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLR--EQQRELEA 2977

Query: 2179 VEAKPELSLEVQLQAERDAIDR--------KEKEITNLEEQLEQFREELENKNEEVQQLH 2230
            +  +   +  +       A+DR         EK + +L   LE+ + +L       +++ 
Sbjct: 2978 MRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMA 3037

Query: 2231 MQLEIQ 2236
             +L+ Q
Sbjct: 3038 AELQFQ 3043



 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 131/692 (18%), Positives = 294/692 (42%), Gaps = 90/692 (13%)

Query: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ-LEHA 1871
            +V +E  E  Q +      G E+ P      L   S L   +EK++    +   + LEH 
Sbjct: 2455 QVVQEAFEKEQEM-----QGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHL 2509

Query: 1872 KVT-QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930
            ++  ++ L+ E         ++L+ Q  +    ++E     + A+  ++A G        
Sbjct: 2510 RLPDRSSLLSE--------IQALRAQLRMTHLQNQEKLQHLRTALTSAEARG-------- 2553

Query: 1931 KTLFERQIQEKTDIID-RLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
             +  E Q++ + +++  ++EQE   A +  + L  EQ++    ++LL             
Sbjct: 2554 -SQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSD 2612

Query: 1977 ---SRQK-EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032
               SRQK E +      V+Q++LQ    L  ++ E++   +++  + Q + +AL+  +EE
Sbjct: 2613 LCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESE-QGKGRALQSQLEE 2671

Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE- 2091
            +  R ++ E +    L +LR   +    Q  ++   L  +   +++ +   + E  + E 
Sbjct: 2672 EQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEA 2731

Query: 2092 ------QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL---------LLSKEQLQ 2136
                   QL  + +     + +T E+ +   H +  T++ S+            +   L 
Sbjct: 2732 LLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALL 2791

Query: 2137 RDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERD 2196
            + ++E    +  L+  + +++Q  L S    +  E +KH  A+  + E+S    L++  +
Sbjct: 2792 QKLKEEKSRVVDLQAMLEKVQQQALHSQQQLE-AEAQKHCEALRREKEVS--ATLKSTVE 2848

Query: 2197 AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK-KESTTRLQELEQ------ 2249
            A+  +++E   L   LE+ RE+      E++Q H +L+ Q+ +++  R  E  Q      
Sbjct: 2849 ALHTQKRE---LRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAE 2905

Query: 2250 ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2309
            + + ++ D EKL    +E +    +D H +  +  Q +++ E + +    ++     +  
Sbjct: 2906 QWRKWQRDKEKL----RELELQRQRDLHKI-KQLQQTVRDLESKDEVPGSRLHLGSARRA 2960

Query: 2310 ITTDNKVIEEKNELIRDLETQIECLMS--------DQECVKRNREEEIEQLNEVIEKLQQ 2361
              +D   + E+    R+LE   + L+S          + V R   +      + +  L  
Sbjct: 2961 AGSDADHLREQQ---RELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017

Query: 2362 ELANIGQKTSMNAHSLSEEADSLKHQ-LDVVIAEKLALEQQVETANEE-MTFMKNVLKET 2419
             L  +    S    S  + A  L+ Q +DV++ + ++L + + T  +E +   + V K  
Sbjct: 3018 TLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLE 3077

Query: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSV 2451
                + L +     + ER + +  ++ P++S+
Sbjct: 3078 KLLKHHLQKGCSPSRSERSAWKPDETAPQSSL 3109



 Score = 60.1 bits (144), Expect = 4e-08
 Identities = 155/746 (20%), Positives = 310/746 (41%), Gaps = 94/746 (12%)

Query: 1958 RLQELEAEQQQIQEERELLSRQKEAMKAEAG----PVEQQLLQETEKLMKEKLEVQCQAE 2013
            R + ++A  Q +++E   +    E +   +G    P ++  +Q+      +  EV     
Sbjct: 2388 RPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACP 2447

Query: 2014 KVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073
              R DL + V+  E   +EQ  + +EL+   +    DL   +  LE+  + +R+  D Q 
Sbjct: 2448 DWRGDLLQVVQ--EAFEKEQEMQGVELQPRLSGS--DLGGHSSLLERLEKIIREQGDLQE 2503

Query: 2074 IDREH----ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
               EH    +R     EIQ L  QL++                 L N  +EK       L
Sbjct: 2504 KSLEHLRLPDRSSLLSEIQALRAQLRMT---------------HLQN--QEKLQHLRTAL 2546

Query: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEV 2189
             S E   R  Q+ ++   ++E    ++EQ   ++ D  + + +       E +   S++ 
Sbjct: 2547 TSAEA--RGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSE-------EQEKANSVQK 2597

Query: 2190 QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2249
             L AE+  +   + ++    ++ EQ    L    +EV QL   L  ++ E    LQELE 
Sbjct: 2598 LLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES 2657

Query: 2250 E---NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKF-AQIIQEKEVEIDQLNEQVTK-- 2303
            E    +  +  +E+  L   + ++ S +    L      Q  Q   + +   +EQ  K  
Sbjct: 2658 EQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDN 2717

Query: 2304 LQQQLKI---TTDNKVIEEK---NELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
            LQ++L+I     +  + +E+   +EL +DL  +    +   E ++  R      L E + 
Sbjct: 2718 LQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHER-----LLTEQLS 2772

Query: 2358 KLQQELANIGQKTSMN---AHSLSEEAD---SLKHQLDVVIAEKLALEQQVETANEEMTF 2411
            +  QE A + Q T  +      L EE      L+  L+ V  + L  +QQ+E   ++   
Sbjct: 2773 QRTQE-ACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCE 2831

Query: 2412 MKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIP---ENSVNVAIDHLSKDKPELEV 2467
                 KE +  +    + L + KRE R S+E+ +  P   +  +  +   L + +     
Sbjct: 2832 ALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAA 2891

Query: 2468 VLTEDALKSLENQTYFKSFEENGKGSIINLET-------RLLQLESTV---SAKDLELTQ 2517
              + +A +S      ++ ++ + K  +  LE        ++ QL+ TV    +KD E+  
Sbjct: 2892 RRSAEARQSPAAAEQWRKWQRD-KEKLRELELQRQRDLHKIKQLQQTVRDLESKD-EVPG 2949

Query: 2518 CYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA-LVSQIQLEAVQEYAKFCQDNQT 2576
                +   +     + + L+++   L+ + +  ++AA L++    +AV    +   D  +
Sbjct: 2950 SRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVD---RTVNDWTS 3006

Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAE--- 2633
             + +   + +  L +L+ D L    S+     +EL+ Q V+     +L K+ V + +   
Sbjct: 3007 SNEKAVMSLLHTLEELKSD-LSRPTSSQKKMAAELQFQFVD-----VLLKDNVSLTKALS 3060

Query: 2634 ---KNVLEKEKKLLELQKLLEGNEKK 2656
               +  LE  + + +L+KLL+ + +K
Sbjct: 3061 TVTQEKLELSRAVSKLEKLLKHHLQK 3086



 Score = 56.6 bits (135), Expect = 5e-07
 Identities = 126/618 (20%), Positives = 244/618 (39%), Gaps = 104/618 (16%)

Query: 2    EDEERQKKLEAGKAKLAQFRQ---------RKAQSDGQSPSKKQKKKRKTSSSKH----D 48
            E EE Q++++  + +L Q  +         ++A  DG+    +QK + K           
Sbjct: 1491 EREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQK 1550

Query: 49   VSAHHDLNIDQSQCN---EMYINSSQRV---ESTVIPESTIMRTLHSG-EITSHEQGFSV 101
             SA   + + + +     EM IN  ++V   +  V  +  I++ L    E+   +Q  S+
Sbjct: 1551 ESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSL 1610

Query: 102  ELESEISTTAD-------DCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSP 154
             L S + +T D          S   G    +   +   L RE E             D  
Sbjct: 1611 LLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESE-----------VLDLK 1659

Query: 155  THLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIK---QRDGIITQLT 211
              LE M+ +L  K  EI  LN +L+ M+ +     L++L+E   ++K    R   I +L 
Sbjct: 1660 EQLEKMKGDLESKNEEILHLNLKLD-MQNSQTAVSLRELEEENTSLKVIYTRSSEIEELK 1718

Query: 212  A---NLQQ-ARREKDETMREFLELTEQSQKLQIQFQQL-----QASETLRNSTHSS---- 258
            A   NLQ+  +R + E   E  +L E  +KLQ +   +     + S++   S  S     
Sbjct: 1719 ATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCS 1778

Query: 259  ---------------TAADLLQAKQQILTHQQQLEEQ--DHLLEDYQKKKEDFTMQISFL 301
                            A +  +A  ++L  Q++   Q  + L +  Q  +E   +Q++ L
Sbjct: 1779 QAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAEL 1838

Query: 302  QEKIKVYEMEQDKKVENSNKEE--IQEKETIIEELNTKI--IEEEKK--TLELKDKLTTA 355
            +  + + E E +       + E  ++ KE  I E N +I  + + K   + EL+  L   
Sbjct: 1839 ERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLAL 1898

Query: 356  DKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE 415
             ++   L++Q +        ++       +  RQ     ++ +    EL +R  + +   
Sbjct: 1899 ARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAH 1958

Query: 416  TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL 475
            T +     Q               M G    Q+  ++   H A +E +    +G+++  L
Sbjct: 1959 TRVPGAHPQP-------------RMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVL 2005

Query: 476  RSYSN------------ITVNEDQIKLMNVAI-NELNIKLQDTNSQKEKLKEELGLILEE 522
             +  +            +TV + Q++   + + NE+ + L+D    KEK+ E+  L   +
Sbjct: 2006 VTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVD 2065

Query: 523  KCALQRQLEDLVEELSFS 540
              A  +QL++ +  L +S
Sbjct: 2066 LVAQVKQLQEKLNRLLYS 2083



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 85/449 (18%), Positives = 180/449 (40%), Gaps = 95/449 (21%)

Query: 2471 EDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQ 2530
            E  ++ +E Q      +  G  S++    ++++ +  +  K LE  +   +   + E   
Sbjct: 2464 EQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQA 2523

Query: 2531 FETEMLQKKIVNLQKIVEEKVAAA------------LVSQIQLEAVQEYAKFC---QDNQ 2575
               ++    + N +K+   + A              L  Q++L A +   + C      +
Sbjct: 2524 LRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQK 2583

Query: 2576 TISSEPERTN-IQNL---NQLREDELGSDI-------SALTLRISELESQVVEMHTSLIL 2624
            T+S E E+ N +Q L    Q    +L SD+         L+  + E++ +V+++ + L  
Sbjct: 2584 TLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSS 2643

Query: 2625 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2684
            ++ +++ A + +  ++ K   LQ  LE  + +  ++E + S + +E L+ +         
Sbjct: 2644 KENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQ-SAKALEELRAS--------- 2693

Query: 2685 SGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN-----------MTSLQKDL 2733
                  LE  RA+S      L   +   + LQ+EL ++ +            ++ LQKDL
Sbjct: 2694 ------LETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747

Query: 2734 SQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
            +  +    E  E L       E   Q +++AC+ +                     + + 
Sbjct: 2748 AAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQ------------------DTQAHHA 2789

Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETL 2853
              Q L +     ++LQ+               EK+++ Q LH+ + L+ E++     E L
Sbjct: 2790 LLQKLKEEKSRVVDLQA-------------MLEKVQQ-QALHSQQQLEAEAQ--KHCEAL 2833

Query: 2854 KREHYVAVQLLKEECGTLKAVIQCLRSKE 2882
            +RE        KE   TLK+ ++ L +++
Sbjct: 2834 RRE--------KEVSATLKSTVEALHTQK 2854



 Score = 42.7 bits (99), Expect = 0.007
 Identities = 97/522 (18%), Positives = 198/522 (37%), Gaps = 90/522 (17%)

Query: 1568 EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ 1627
            E+    +     L   E +L+   QEL  +  + +     L +  +R ++R+ +  + L+
Sbjct: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688

Query: 1628 EEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687
            E    L  Q AQ S                               +LC  L++  T   N
Sbjct: 2689 ELRASLETQRAQSS-------------------------------RLCVALKHEQTAKDN 2717

Query: 1688 GNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEE 1747
                          +KEL R        +L+ ER  L    + L K L      T  + E
Sbjct: 2718 -------------LQKEL-RIEHSRCEALLAQERSQL----SELQKDLAAEKSRTLELSE 2759

Query: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807
             + RH   + ++ S+    A +   ++A  ++   + EE +RV D               
Sbjct: 2760 AL-RHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQA------------ 2806

Query: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQA----------AVEKL 1857
              M  KV ++     Q+L        E     +E+   + S ++A          ++E+ 
Sbjct: 2807 --MLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864

Query: 1858 LEAISETSSQLE--HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915
             E  +   ++LE  H ++ + E  R++ R+  EA +S    E+ R+   ++ + RE   +
Sbjct: 2865 REKPAWLQAELEQSHPRLKEQE-GRKAARRSAEARQSPAAAEQWRKWQRDKEKLRE---L 2920

Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIID---RLEQELLCASNRLQELEAEQQQIQEE 1972
            EL +   +      ++T+  R ++ K ++      L      A +    L  +Q++++  
Sbjct: 2921 ELQRQRDLHKIKQLQQTV--RDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAM 2978

Query: 1973 RE-LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031
            R+ LLS  +      +  V++ +   T    K  + +    E+++ DL +   + +    
Sbjct: 2979 RQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAA 3038

Query: 2032 EQVSRFIELEQEKNTE----LMDLRQQNQALEKQLEKMRKFL 2069
            E   +F+++  + N      L  + Q+   L + + K+ K L
Sbjct: 3039 ELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLL 3080



 Score = 39.3 bits (90), Expect = 0.077
 Identities = 59/279 (21%), Positives = 117/279 (41%), Gaps = 27/279 (9%)

Query: 3094 IQALHAQMNGRKITLKREQESE--KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3151
            ++ L  +    K+   R  E E  K + E L+ N ++ Q +  E   E+  + +   +LQ
Sbjct: 1694 LRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAE---EIEQLHEVIEKLQ 1750

Query: 3152 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3211
             +LS    VV E+    A +   L++ L          +A + E++   +    L+  LA
Sbjct: 1751 HELSLMGPVVHEVSDSQAGS---LQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA 1807

Query: 3212 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLN 3271
             ++++  +   ALE  + +L  +EE  + +L +L        +RN+ L    E + + + 
Sbjct: 1808 DQERRHSQ---ALEALQQRLQGAEEAAELQLAEL--------ERNVALR---EAEVEDMA 1853

Query: 3272 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331
               Q+ E+     +A ++E   RNLE+  L + +     E+ + L     +   L+    
Sbjct: 1854 SRIQEFEAALKAKEATIAE---RNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPL 1910

Query: 3332 TGQSRPPLPS--EDLLKELQKQLEEKHSRIVELLNETEK 3368
               + PP           L +QL+  H R +    E ++
Sbjct: 1911 AAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDR 1949


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  306 bits (785), Expect = 2e-82
 Identities = 629/3083 (20%), Positives = 1251/3083 (40%), Gaps = 460/3083 (14%)

Query: 1    MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
            ++D  RQK ++  +   A   +RKA  +     K   K + TS +K              
Sbjct: 64   LKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK-------------- 109

Query: 61   QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
                 YI   +    TV+P         S E  S     S E E EI         +   
Sbjct: 110  -----YIEEMKAQGGTVLPTEP-----QSEEQLSKHDKSSTEEEMEIEKIKHKLQEK--- 156

Query: 121  CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE---MMESELAGKQHEIEELNRE 177
                        L+   +  +  + +EQ AQ S T +E   MM+ +L  K+  I  L  +
Sbjct: 157  ----------EELISTLQAQLTQAQAEQPAQSS-TEMEEFVMMKQQLQEKEEFISTLQAQ 205

Query: 178  LEEMRVTYGTEGLQQLQE--FEAAIKQRDGIITQLTAN-------------LQQARREKD 222
            L + +     + + + ++  FE  ++  +  + QL                LQ+   E +
Sbjct: 206  LSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHE 265

Query: 223  ETMR------EFL--ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
            E++       + L  ELT   Q+ QI  QQLQ  E   N+  ++   +  ++K  IL  +
Sbjct: 266  ESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESK--ILLEK 323

Query: 275  QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEEIQEKETIIEE 333
             +LE  +  L  +  ++E   +   F Q      E+E +   +E  +K E++EK + I  
Sbjct: 324  MELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383

Query: 334  LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393
            L     E +     LKD+     KLL +  EQ VQ  Q I+ ++ +L       +Q S+E
Sbjct: 384  LQKTGQELQSACDALKDQ---NSKLLQDKNEQAVQSAQTIQQLEDQL-------QQKSKE 433

Query: 394  IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL- 452
            I Q +  +   Q      + F     +  +  T+  +  L+  + E+  ++   +   + 
Sbjct: 434  ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493

Query: 453  IRQHMAQMEEMKTR-----HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
            + +  A+ E++ ++      +     A R  S I++ +   K  + A       L++T S
Sbjct: 494  LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553

Query: 508  QKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL-- 565
            QK K   EL ++L E       +++  EE++F + Q+Q  R   A+ E    +  K +  
Sbjct: 554  QKHK---ELSVLLLE-------MKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEG 603

Query: 566  STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL 625
              +  +K + V   ++ ++  L     + N +  L  +EKE+ +   +   S+E  L   
Sbjct: 604  EGIAPIKMK-VFLEDTGQDFPL-----MPNEESSLPAVEKEQASTEHQSRTSEEISLNDA 657

Query: 626  RTQLLFS-----------------HEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
              +L  +                 H++EL +LK  + +E  +N  K ++     Y++ +D
Sbjct: 658  GVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI-LELELNFHKAQE----IYEKNLD 712

Query: 669  GLQNEMS---QKIETMQFEKDN-------LITKQNQLILEISKLKDLQQSLVNSKSEEMT 718
                E+S   Q IE  +   DN       L  +++QL+ ++ +L  + +     K  EM 
Sbjct: 713  EKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMN 772

Query: 719  LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778
            L   E Q+ ++   Q   +   L +++  L ++ +  + +++  +N+L +   Q   +++
Sbjct: 773  LAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQST 831

Query: 779  ILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI------LIEENEDL 832
            +++  +  L++  K    +   ER+  + S   +   ++ +KE+EI      L+E+  D+
Sbjct: 832  LIRSLQSQLQN--KESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDV 889

Query: 833  K--QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK 890
            +  QQ I+  ++ +    +FS  EK  ++N    +E+++  +++K        K++L   
Sbjct: 890  ETLQQTIEEKDQ-QVTEISFSMTEKMVQLN----EEKFSLGVEIK------TLKEQLNLL 938

Query: 891  SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
            S+ +   +E  ++  N  +  +K + +D          EM    +    EL  + ++ K+
Sbjct: 939  SRAEEAKKE-QVEEDNEVSSGLKQN-YD----------EMSPAGQISKEELQHEFDLLKK 986

Query: 951  EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE-KEQVSLRCREL-EIIINHNRAEN 1008
            E  +  ++L       K+    +S L EE+ +LK E K+++ L   E  E+  +    E 
Sbjct: 987  ENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY 1046

Query: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1068
             + C T     ++  +  T    E  +  + K         +E+K++ E        +  
Sbjct: 1047 SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD--------LEEKLAAEEQFQALVKQMN 1098

Query: 1069 QLILDHLPSVTKESSLRATQPSENDKLQKEL---NVLKSEQNDLRLQMEAQRICLSLVYS 1125
            Q + D     T +  L   + SEN  + ++L   N   S+ + + L  E      ++V S
Sbjct: 1099 QTLQDK----TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE------TVVIS 1148

Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1185
                   E+ + E         EE I A E++ ++LQK  Q  L + K            
Sbjct: 1149 PPCTGSSEHWKPE--------LEEKILALEKEKEQLQKKLQEALTSRKA----------- 1189

Query: 1186 LLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDP--ELQ 1243
                 + K   E+  +  + L     +Y     + +  +++ EN GD + + +    E  
Sbjct: 1190 -----ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESI 1244

Query: 1244 DYRYEVQDFQEN------MHTLLNKVTEEYNKLLVLQTRLSKIW-GQQTDGMKLEFGEEN 1296
            D +    D QE+      +   L K TE+++   VL++ L   W     D   L+ G   
Sbjct: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGG--- 1301

Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356
                 T    I +Q+  +E   V  + K+SS    E TK  E+V +L+  I+    +++ 
Sbjct: 1302 -----TSVAQIKAQLKEIEAEKVELELKVSSTTS-ELTKKSEEVFQLQEQINKQGLEIES 1355

Query: 1357 TEQ-NYEAEIHC--LQKRLQAVSES--------TVPPSLPVDSVVITESDAQRTMYPGSC 1405
             +  ++EAE+H   LQ++L++             + P L     +I++ +   +   G  
Sbjct: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415

Query: 1406 VKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL---EEEVAKVIVSMSIAFAQQTELS 1462
             +K    T     +  + E+ +++K L  Q + Q    +E + ++ V +     +  E+ 
Sbjct: 1416 SEKEAALT---KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIG 1472

Query: 1463 RISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG 1522
              S  K+      QA  + ++E     E K  Q+++            +   + L+K L 
Sbjct: 1473 EESRAKQQIQRKLQAALISRKEA--LKENKSLQEELSLA---------RGTIERLTKSLA 1521

Query: 1523 EHGKEILLSNSDPHDIPESKDCVL----TISEEMFSKDKTFI-VRQSIHDEISVSSMDAS 1577
            +   ++   N +       KD VL     + EE   +DK    + +S+ +  S+SS   S
Sbjct: 1522 DVESQVSAQNKE-------KDTVLGRLALLQEE---RDKLITEMDRSLLENQSLSSSCES 1571

Query: 1578 RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL 1637
             +L L  E L + +++LV++        E L+ + + +    +E  ++LQ+E + L   L
Sbjct: 1572 LKLAL--EGLTEDKEKLVKE-------IESLKSSKIAESTEWQEKHKELQKEYEIL---L 1619

Query: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEE 1697
                ++ NE   +ER + ++E +   KQ             + +  Q Q   +   E++E
Sbjct: 1620 QSYENVSNE---AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKE 1676

Query: 1698 QTFK------------EKELDRKPEDV-PPEILSNERYALQKANNRLLKILLEVVKTTAA 1744
            +  K            E+E DR   +V P    + E      ++N  +K  LE VK    
Sbjct: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME-- 1734

Query: 1745 VEETIGRHVLGIL-DRSSKSQSSASLIWRSEAEASVKSCV-----HEEHTRVTDESIPSY 1798
              ET+ +    ++ ++ S S+    L  + E   S ++ +     H+  T VT+E   S 
Sbjct: 1735 -YETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793

Query: 1799 SGSDMPRNDINMWSKVT----------------------EEGTELSQRL--VRSGFAGTE 1834
             G    ++ ++M ++ T                      +E     Q++  ++   AG E
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853

Query: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLE--HAKVTQTELMRESFRQKQEATES 1892
               E ++     S  L+     LL  IS    +L+    +VT+  L+ +  +++      
Sbjct: 1854 ---EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK 1910

Query: 1893 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952
            LK   E      E+    E+L  +L++  G I  Y  + T  + QI+      + LE E+
Sbjct: 1911 LKETAE-----EEKDDLEERLMNQLAELNGSIGNYCQDVT--DAQIKN-----ELLESEM 1958

Query: 1953 LCASNRLQELEAEQQQIQEERELLSRQ--KEAMK----AEAGPVEQQLLQETEKLMKEKL 2006
                  + ELE E+QQ+ +E+  +  +  KE ++    A+  P  +   +E ++L+KEK 
Sbjct: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQ 2018

Query: 2007 EVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR 2066
            +   Q +K     Q+++ ALE  V  +   F++ E +K     DL    + L + +E  +
Sbjct: 2019 QEVKQLQKDCIRYQEKISALERTV--KALEFVQTESQK-----DLEITKENLAQAVEHRK 2071

Query: 2067 KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126
            K   E A  +    D   +  + L   LK+    Q   E    +++Q    L+ + ++  
Sbjct: 2072 KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE 2131

Query: 2127 EL-LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL 2185
            E  L  K+ +Q  +     E   LE  + E++  L       Q++++       +     
Sbjct: 2132 EKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFT 2191

Query: 2186 SLEVQLQAERD-AIDRKEKEITNLEEQLEQFREELENKNEEVQQLH---MQLEIQKKEST 2241
                 LQ +RD  ID  +K      + ++   EE+  K +    L     Q+ I  +E  
Sbjct: 2192 KSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251

Query: 2242 TRLQELEQENKLFKDDME-KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2300
              +  LE + ++++   + ++ L  K  D +  +++ +L    +Q+ + + +     NE 
Sbjct: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELL----SQLEETRHLYHSSQNE- 2306

Query: 2301 VTKLQQQLKITTDNKV-IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2359
            + KL+ +LK   D    +    E  ++ +  +E ++  QE   +N +   EQL   ++  
Sbjct: 2307 LAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS 2366

Query: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEK--------LALEQQVETANEEMTF 2411
            ++  + + ++ +M    +       +  + V IAE           LE  +    EE   
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426

Query: 2412 MKNVLKETNFKMNQLTQELFSLKRER--------ESVEKIQSIPENSVNVAIDHLSKDKP 2463
            ++   K+   K NQL + L ++K+E           V+ + S+  +   +  D+   ++ 
Sbjct: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEER 2486

Query: 2464 ELEVVLTEDALKSLENQTYFKSFEENG--KGSIINLETRLLQLESTVSAKDLELTQCYKQ 2521
             L ++L +D       Q   ++  EN   K  I  L + +  L S  +  D EL Q Y++
Sbjct: 2487 HLSIILEKD-------QLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQ-YRE 2538

Query: 2522 -------IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN 2574
                   IKD Q++   E ++ Q K                      E   +YAK  ++ 
Sbjct: 2539 DLNQVITIKDSQQKQLLEVQLQQNK----------------------ELENKYAKL-EEK 2575

Query: 2575 QTISSEPERTNIQNLNQLRED--ELGSDISALTLRISELESQVVEM---------HTSLI 2623
               S E      ++ N L+E+  +L  +I +L + IS+L  QV  +         H  L 
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLK 2635

Query: 2624 LEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE 2683
            +++E+V          +K++ EL++     E    +KE  +   ++E  K   EL H + 
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELEE-----ELVCVQKEAAKKVGEIED-KLKKELKHLHH 2689

Query: 2684 ESGFF-NELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAE 2742
            ++G   NE E           +L   ++K   + +E       + S  + +S +++    
Sbjct: 2690 DAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDH 2749

Query: 2743 AKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNA 2802
            A E+L  L+++ +  ++E  +    + L  +   ++ S+T  ++  +  N    +     
Sbjct: 2750 ANEELDELKRKYDASLKELAQ-LKEQGLLNRERDALLSETAFSMNSTEENSLSHL----- 2803

Query: 2803 GIQINLQSECSSEEVTEIISQFTEKIEKMQEL-HAAEILDMESRHISETETLKREHYVAV 2861
              ++N Q     E++  + SQ  +   ++Q    A   L  E  H+       R+     
Sbjct: 2804 -EKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGK 2862

Query: 2862 QLLKEECGTLKAVIQCLRSKEGS 2884
            Q    +  T  A +Q L+    S
Sbjct: 2863 QRSAAQPSTSPAEVQSLKKAMSS 2885



 Score =  297 bits (761), Expect = 1e-79
 Identities = 684/3361 (20%), Positives = 1389/3361 (41%), Gaps = 512/3361 (15%)

Query: 490  LMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
            L NV ++EL+       + +  L  EL    + +     Q ED+ E L+++ + +   + 
Sbjct: 8    LANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQ-EDVQERLAYAEQLVVELKD 66

Query: 550  TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609
             I +++ +L +  ++L   E+ KA    A    K+L+L  +A++T+    +E ++ +   
Sbjct: 67   IIRQKDVQLQQKDEALQ--EERKA----ADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT 120

Query: 610  VLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG 669
            VL    +S+E          L  H++  S  +E++EIE   +  + K+ L    + Q+  
Sbjct: 121  VLPTEPQSEEQ---------LSKHDK--SSTEEEMEIEKIKHKLQEKEELISTLQAQLTQ 169

Query: 670  LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI---NELQK 726
             Q E   +  T   E +  +  + QL  +   +  LQ  L  +++E+   Q+    + + 
Sbjct: 170  AQAEQPAQSST---EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARF 226

Query: 727  EIEI-LRQEEKEKGTLEQEVQ-ELQLKTELLEKQMKEKENDL----------QEKFAQLE 774
            E ++ L ++E  +   + +V+ E+Q K  +L+++++E E  L          Q++    E
Sbjct: 227  ETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAE 286

Query: 775  AENSILKDEKKTLE---DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
              N IL  + + +E   + L+      +EE  I L+ ++ +    V E+++        +
Sbjct: 287  QRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELE----VAERKLSF-----HN 337

Query: 832  LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKS 891
            L+++   L E+ E+       A+   E  Y  L++++   ++ K     S  K   E +S
Sbjct: 338  LQEEMHHLLEQFEQAGQ----AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQS 393

Query: 892  KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKRE 951
               AL ++      N   ++ K+    +    + +  +  +   K+ ++ + +L + + E
Sbjct: 394  ACDALKDQ------NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447

Query: 952  KLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 1010
                +      +E  +    E I+ L + V  L+ EK  + L   ELE +    +AEN +
Sbjct: 448  TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL----KAEN-E 502

Query: 1011 SCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL 1070
               +Q++ L     T  +      +S V+ +    S      +   EN T  ++ K+  +
Sbjct: 503  KLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLEN-TFSQKHKELSV 561

Query: 1071 ILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC--LSLVYSTHV 1128
            +L  +    +E +    Q       + +  VL  +Q +++ QME + I      V+    
Sbjct: 562  LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL--DQKEMK-QMEGEGIAPIKMKVFLEDT 618

Query: 1129 DQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188
             Q    M NE+       KE+     + +  E   ++   ++   T++ GD+       I
Sbjct: 619  GQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDI 678

Query: 1189 GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE 1248
            G+  +   E                 +  L+ E+N    +   +   + +  E+ +    
Sbjct: 679  GQCHQDELERLK--------------SQILELELNFHKAQEIYEKNLDEKAKEISNLNQL 724

Query: 1249 VQDFQENMH---TLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG---EENLPKEET 1302
            +++F++N     +    ++EE ++LL     LS +   +    +LE      E   + + 
Sbjct: 725  IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 784

Query: 1303 EFLSIHSQMTN--LEDIDVNHKSKLSSLQDLEKTKLEEQVQ--ELESLISSLQQQL--KE 1356
            E  + H  +    +  + +  KSK   ++ L+    + Q+Q  E  +LI SLQ QL  KE
Sbjct: 785  ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 844

Query: 1357 TEQNYEAE-IHCLQKRLQAVSESTVPPSLPVDSV----------------VITESDAQRT 1399
            +E    AE +  +  +++ +S++     L +  +                 I E D Q T
Sbjct: 845  SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 904

Query: 1400 MYPGSCVKKNIDGTIEFSGEFGV-----KEETNIVKLLEKQYQEQLEEEVAKVIVSMSIA 1454
                S  +K +    E     GV     KE+ N++   E+  +EQ+EE+           
Sbjct: 905  EISFSMTEKMVQLNEE-KFSLGVEIKTLKEQLNLLSRAEEAKKEQVEED----------- 952

Query: 1455 FAQQTELSRISGGKENTASSKQAHAVCQQE-QHYFNEMKLSQDQIGFQTFETVDVKFKEE 1513
                 E+S  SG K+N      A  + ++E QH F+ +K   +Q   +  +   +  KE 
Sbjct: 953  ----NEVS--SGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRK-RKLQAALINRKEL 1005

Query: 1514 FKPLSK---ELG----EHGKEILLSNSDPHDIPESKD-------CVLTISEEMFSKDKTF 1559
             + +S+   EL     E  KEI LS ++  ++ E K+       CV +  +E+       
Sbjct: 1006 LQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEI-----EI 1060

Query: 1560 IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619
             ++Q+I ++               E +L+ +R++L  +    +Q   L++Q  M Q  + 
Sbjct: 1061 YLKQTISEK---------------EVELQHIRKDLEEKLAAEEQFQALVKQ--MNQTLQD 1103

Query: 1620 REDQ-EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678
            + +Q + LQ EI   N+ + Q+    N +        L++E   +        E    EL
Sbjct: 1104 KTNQIDLLQAEISE-NQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL 1162

Query: 1679 RNSSTQTQNGNEN-QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN-NRLLKILL 1736
                   +   E  Q +++E     K + +K ++    +   E    QK + NRL +   
Sbjct: 1163 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHL--REELKQQKDDYNRLQEQFD 1220

Query: 1737 EVVKTTAAVEETIGR-------HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTR 1789
            E  K    + + + +        + G L  + + +S +S       E  +     + HT+
Sbjct: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST---PGLEEPLFKATEQHHTQ 1277

Query: 1790 VTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSR 1849
               ES       D P +  +  +   + GT ++Q   +      EI+ E  EL L +SS 
Sbjct: 1278 PVLESNLC---PDWPSHSED--ASALQGGTSVAQIKAQL----KEIEAEKVELELKVSS- 1327

Query: 1850 LQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRA 1909
                          T+S+L       T+   E F+ +++  +     E L+   HE    
Sbjct: 1328 --------------TTSEL-------TKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVH 1366

Query: 1910 REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQI 1969
             E L  +L  ++  I G    + L + ++ E   +I + E+++   S +L E EA   +I
Sbjct: 1367 AESLQQKLESSQLQIAGLEHLREL-QPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI 1425

Query: 1970 QEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEID 2029
            Q E   +  Q++ +KA    +E Q  +  E++ + ++E+ C+ ++  +++ ++ +A    
Sbjct: 1426 QTE---IIEQEDLIKALHTQLEMQAKEHDERIKQLQVEL-CEMKQKPEEIGEESRA---- 1477

Query: 2030 VEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQK 2089
             ++Q+ R ++       E +   ++N++L+++L   R  ++      +   DV  Q   +
Sbjct: 1478 -KQQIQRKLQAALISRKEAL---KENKSLQEELSLARGTIERLT---KSLADVESQVSAQ 1530

Query: 2090 LEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKL 2149
             +++  V+ R   + E + + + ++   L E     S    S E L+  ++   E+ EKL
Sbjct: 1531 NKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSS----SCESLKLALEGLTEDKEKL 1586

Query: 2150 EFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLE 2209
               +  L+ + +  +  +Q+    KH              +LQ E + + +  + ++N  
Sbjct: 1587 VKEIESLKSSKIAESTEWQE----KH-------------KELQKEYEILLQSYENVSNEA 1629

Query: 2210 EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESD 2269
            E+++   E +  + +E+       E  KKE+  +LQE EQE +  K+ M K         
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKF-------- 1681

Query: 2270 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK-----ITTDNKVIEEKNELI 2324
            A S Q          Q I E E E D+L  +V       K     + + N  ++E+ E +
Sbjct: 1682 AKSKQ----------QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731

Query: 2325 R----DLETQIECLMSDQECVKRNREEEIEQLNEVIE------------KLQQELANIGQ 2368
            +     L  + + LMS+++ +     EE++ L   IE            +      N+ +
Sbjct: 1732 KMEYETLSKKFQSLMSEKDSLS----EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTE 1787

Query: 2369 KTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
            + + +    +EE DSL        +E +   +    A  +     + +     +++QL +
Sbjct: 1788 EGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKE 1847

Query: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ-------- 2480
             +  L+ E++  ++     EN  N  +  +S    EL+++  E    +L NQ        
Sbjct: 1848 RIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSR 1907

Query: 2481 -TYFKSFEENGKGSIIN-LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2538
             T  K   E  K  +   L  +L +L  ++     ++T             Q + E+L+ 
Sbjct: 1908 VTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA-----------QIKNELLES 1956

Query: 2539 KIVNLQKIVEE--KVAAALVSQ---IQLEAVQEYAKFCQD------NQTISSEPE---RT 2584
            ++ NL+K V E  +    LV +   ++ E  +EY +  Q       N++ + E +   + 
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKE 2016

Query: 2585 NIQNLNQLRED--ELGSDISALTLRISELESQVVEMHTSLILEKE------------QVE 2630
              Q + QL++D       ISAL   +  LE    E    L + KE            Q E
Sbjct: 2017 KQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAE 2076

Query: 2631 IAEKNVLEKEKKL---------LELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHS 2681
            +A   VL  + +          L+L+K L+ N K+  + + K+  +D+E      E  H 
Sbjct: 2077 LASFKVLLDDTQSEAARVLADNLKLKKELQSN-KESVKSQMKQKDEDLERRLEQAEEKHL 2135

Query: 2682 NEESGFFNELEALRAESVATKAELASYK-------EKAEKLQEELLVKET-------NMT 2727
             E+     +L+ALR E V  +  +   +       ++ ++LQE L    T       +M+
Sbjct: 2136 KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMS 2195

Query: 2728 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLK 2787
            SLQ D  +V D   + + K S   +  E E++  +  C    L  +L +      +  + 
Sbjct: 2196 SLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV--LKDQLRQMSIHMEELKIN 2253

Query: 2788 ISSSNQTPQILVKNAGIQINLQSECSSE---EVTEIISQFTEKIEKMQELHAAEILDMES 2844
            IS      QI    A  ++ LQ +       E  E++SQ  E+   +      E+  +ES
Sbjct: 2254 ISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQL-EETRHLYHSSQNELAKLES 2312

Query: 2845 RHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSD 2904
               S  + L  +   +++  KE+ G L+ +I   R +E          +  +T    S +
Sbjct: 2313 ELKSLKDQLT-DLSNSLEKCKEQKGNLEGII---RQQEADIQNSKFSYEQLETDLQASRE 2368

Query: 2905 SGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESP 2964
              S   + I +   +   + S G+ E  + A           LR  H++ ++ L   E+ 
Sbjct: 2369 LTSRLHEEINMKEQKIISLLS-GKEEAIQVAIAE--------LRQQHDKEIKEL---ENL 2416

Query: 2965 YSDGEDHSI--QQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDW 3022
             S  E+ +I  ++ ++  +++    + T+ ++K    K  +Q++A++    +S  S  + 
Sbjct: 2417 LSQEEEENIVLEEENKKAVDKTNQLMETLKTIK----KENIQQKAQLDSFVKSMSSLQND 2472

Query: 3023 RGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECL 3082
            R  ++   QQ  LEER + +   + +L      +          +++E+    ++ M+ L
Sbjct: 2473 RDRIVGDYQQ--LEERHLSIILEKDQLIQEAAAE--------NNKLKEEIRGLRSHMDDL 2522

Query: 3083 QKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQK---QSQMLEMQVE 3139
              ++   L +E+      +N + IT+K  Q+     ++LLE  +QQ    +++  +++ +
Sbjct: 2523 N-SENAKLDAELIQYREDLN-QVITIKDSQQ-----KQLLEVQLQQNKELENKYAKLEEK 2575

Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE---LEAFRLEV 3196
            L   ++   +L+   ++ +    +L  E+   K+ + + L  Q   L+E   L  +  ++
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI-SQLTRQVTALQEEGTLGLYHAQL 2634

Query: 3197 KDKTDEVHLLNDTLASEQKKSRELQWAL---EKEKAK-LGRSEERDKEELEDL------- 3245
            K K +EVH L+   +S QK+  EL+  L   +KE AK +G  E++ K+EL+ L       
Sbjct: 2635 KVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIM 2694

Query: 3246 KFSLESQKQRNLQL--NLLLEQQKQLLNESQQK-IESQRMLYDAQLSEEQGR----NLEL 3298
            +   E+ ++R  +L  +L+  +QK L+   + K + +Q   +   +S  Q      N EL
Sbjct: 2695 RNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL 2754

Query: 3299 QVLLESEKVRIREMSST-----LDRERE--LHAQLQSSDGTGQS---------RPPLPSE 3342
              L       ++E++       L+RER+  L     S + T ++         +  L  +
Sbjct: 2755 DELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKD 2814

Query: 3343 DLLKELQKQLEEKHSRIVE--------------LLNETEKYKLDSLQTRQQMEKDRQVHR 3388
            + L  L  QLE+ ++++                L NE EK++  S + +Q+         
Sbjct: 2815 EQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR-KSEEGKQRSAAQPSTSP 2873

Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV---YKLDLEGQRLQGIMQEFQ- 3444
              +Q+ ++A +  Q     L  ++++LQ+Q  +  Q++   + L  + Q  Q   + FQ 
Sbjct: 2874 AEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQI 2933

Query: 3445 KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGG 3504
             QE  R+E    +  L+Q   E ++W +   R +   L    + + + S+   LI     
Sbjct: 2934 MQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI----- 2988

Query: 3505 GTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKL 3564
                        ++L+  +S+ Q L  +   +   ET+   D          ++ + + L
Sbjct: 2989 ------------RELRSSSSQTQPLKVQYQRQASPETSASPD------GSQNLVYETELL 3030

Query: 3565 TGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYR 3624
              Q  +         S   + ++ LR   +L  + SQL EEKN L   +    + +R  +
Sbjct: 3031 RTQLND---------SLKEIHQKELRIQ-QLNSNFSQLLEEKNTLSIQLCDTSQSLRENQ 3080

Query: 3625 Q 3625
            Q
Sbjct: 3081 Q 3081



 Score =  285 bits (729), Expect = 6e-76
 Identities = 673/3382 (19%), Positives = 1376/3382 (40%), Gaps = 522/3382 (15%)

Query: 311  EQDKKVENSNKEEIQEKETIIEELNTKI-----------------IEEEKKT-------- 345
            E D +  N+ +E++QE+    E+L  ++                 ++EE+K         
Sbjct: 37   ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKL 96

Query: 346  -LELKDKLTTADKLLGEL--------------QEQIVQKNQEIKNMKLELTNSKQKERQS 390
             L  K KLT+ +K + E+              +EQ+ + ++     ++E+   K K ++ 
Sbjct: 97   KLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEK 156

Query: 391  SEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450
             E I  L   + + Q      S  E +    M+Q+ Q K E +     ++   Q  Q  Q
Sbjct: 157  EELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ 216

Query: 451  ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE 510
            +++R+  A+ E     H+ E+   +      T  + +++++   + E    L       +
Sbjct: 217  QVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVD 276

Query: 511  KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ--TIAEQESKLNEAHKSLS-- 566
             L++EL    +    L +QL+ +  E +  R  ++  R+   I  ++ +L  A + LS  
Sbjct: 277  LLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH 336

Query: 567  ----TVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAV-LDRMAESQEAE 621
                 +  L  +   A +++ ELE ++ A     K K EM EK  + + L +  +  ++ 
Sbjct: 337  NLQEEMHHLLEQFEQAGQAQAELESRYSA--LEQKHKAEMEEKTSHILSLQKTGQELQSA 394

Query: 622  LERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681
             + L+        ++ SKL +D            K+   +   Q I  L++++ QK + +
Sbjct: 395  CDALK--------DQNSKLLQD------------KNEQAVQSAQTIQQLEDQLQQKSKEI 434

Query: 682  QFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL 741
                + L  +Q++   + S   D+      + +EE    I  LQK +  L   E EKG L
Sbjct: 435  SQFLNRLPLQQHETASQTS-FPDVYNEGTQAVTEE---NIASLQKRVVEL---ENEKGAL 487

Query: 742  EQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE----DMLKIHTPV 797
                 EL+        ++K +   L  +   LEA+N   + +++  E    D+    +  
Sbjct: 488  LLSSIELE--------ELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSS 539

Query: 798  SQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNF 857
            ++E     L++  S+       KE+ +L+ E ++ +++   L  +++ +R   +  E   
Sbjct: 540  AEESGQDVLENTFSQK-----HKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLD 594

Query: 858  EVNYQELQEEYACLLKVKDDLEDSKNKQEL--EYKSKLKALNEEL----HLQR------I 905
            +   ++++ E    +K+K  LED+     L    +S L A+ +E     H  R      +
Sbjct: 595  QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654

Query: 906  NPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE- 964
            N   V++KS+  D DK+  A   ++G+  +       ++LE  K + LEL        E 
Sbjct: 655  NDAGVELKSTKQDGDKSLSA-VPDIGQCHQ-------DELERLKSQILELELNFHKAQEI 706

Query: 965  ---QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
                L +K  EIS LN+ ++  K+                    A+N  S  T +S   D
Sbjct: 707  YEKNLDEKAKEISNLNQLIEEFKK-------------------NADNNSSAFTALSEERD 747

Query: 1022 GVVTMTSR-----GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLP 1076
             +++              V ++  +  E  +   + ++ +E+ T  +    EQ+   H  
Sbjct: 748  QLLSQVKELSMVTELRAQVKQLEMNLAEAER---QRRLDYESQTAHDNLLTEQI---HSL 801

Query: 1077 SVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYME 1136
            S+  +S               ++ VL++E +D++LQ   Q   +  + S   ++  E +E
Sbjct: 802  SIEAKSK------------DVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE 849

Query: 1137 N-EKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQET------GDEGKPLHLLIG 1189
              E+ + + S  EEL  A  +K  E+ K+ QL L+  +  ET        + +   +   
Sbjct: 850  GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFS 909

Query: 1190 KLQKAVS-EECSYFLQTLCSVLGEYYT------PALKCEVNAEDKENSGDYISENEDPEL 1242
              +K V   E  + L      L E          A K +V  +++ +SG  + +N D   
Sbjct: 910  MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSG--LKQNYDEMS 967

Query: 1243 QDYRYEVQDFQENMHTLLNKVTEEYNKLL--------VLQTRLSKIWGQQTDGMKLEFGE 1294
               +   ++ Q     LL K  E+  + L         L  R+S++  ++   +K E  +
Sbjct: 968  PAGQISKEELQHEF-DLLKKENEQRKRKLQAALINRKELLQRVSRL-EEELANLKDE-SK 1024

Query: 1295 ENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQL 1354
            + +P  ETE   +     N E  +    SK   ++   K  + E+  EL+ +   L+++L
Sbjct: 1025 KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL 1084

Query: 1355 KETEQNYEAEIHCLQKRLQ------AVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKK 1408
               EQ ++A +  + + LQ       + ++ +  +  +   +IT +         + VK+
Sbjct: 1085 AAEEQ-FQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143

Query: 1409 N--IDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
               I      S E    E    +  LEK+ +EQL++++ + + S      +  E  R   
Sbjct: 1144 TVVISPPCTGSSEHWKPELEEKILALEKE-KEQLQKKLQEALTSRKAILKKAQEKERHL- 1201

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIG-------FQTFETVDVKFKEE------ 1513
             +E     K  +   Q++   F+E     + IG        Q  E++D K          
Sbjct: 1202 -REELKQQKDDYNRLQEQ---FDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESC 1257

Query: 1514 ------FKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTI----SEEMFSKDKTFIVRQ 1563
                   +PL K   +H  + +L ++   D P   +    +    S          I  +
Sbjct: 1258 SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE 1317

Query: 1564 SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMR-QMERQRED 1622
             +  E+ VSS   + +L    E++  +++++ +Q  E +    +  +A +  +  +Q+ +
Sbjct: 1318 KVELELKVSS--TTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375

Query: 1623 QEQLQ----EEIKRLNRQL--AQRSSIDNENLVSERERVLLEELEALK--QLSLAGREKL 1674
              QLQ    E ++ L  +L   Q+     E  VS     L E+  AL   Q  +  +E L
Sbjct: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435

Query: 1675 CCELRNSSTQTQ-NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLK 1733
               ++   TQ +    E+   +++   +  E+ +KPE++  E  S  +  +Q+     L 
Sbjct: 1436 ---IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE--SRAKQQIQRKLQAALI 1490

Query: 1734 ILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVK---------SCVH 1784
               E +K   +++E +     G ++R +KS +       S+  A  K         + + 
Sbjct: 1491 SRKEALKENKSLQEELSL-ARGTIERLTKSLADV----ESQVSAQNKEKDTVLGRLALLQ 1545

Query: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR-------SGFA-GTEID 1836
            EE  ++  E   S   +    +         E  TE  ++LV+       S  A  TE  
Sbjct: 1546 EERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQ 1605

Query: 1837 PENEELMLNISSRLQA---------AVEKLLEAISETSSQLEHAKVTQTEL-MRESFRQK 1886
             +++EL       LQ+          ++ ++EA+ +   +L + K+  TE   +E+ +Q 
Sbjct: 1606 EKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQEL-YGKLRSTEANKKETEKQL 1664

Query: 1887 QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE---------KTLFERQ 1937
            QEA + +   EE++E++ + +++++Q  +EL +    +               +TL    
Sbjct: 1665 QEAEQEM---EEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721

Query: 1938 IQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVE------ 1991
               K + ++R++ E    S + Q L +E+  + EE + L  Q E   ++   +E      
Sbjct: 1722 ASMKEE-LERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD 1780

Query: 1992 ----------QQLLQETEKLMKEKLEVQ--CQAEKVRDDLQKQVKALEIDVEEQVSRF-- 2037
                      Q +  ETE+     +  +  C              + +    ++++ +  
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840

Query: 2038 -IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI-------QK 2089
             I+  +E+   L + +Q+N+   + LE  +  L  Q   ++ E  + Q+E+       Q+
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900

Query: 2090 LEQQLKVVPRFQPISEHQTREVEQ-LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEK 2148
            ++++L  V + +  +E +  ++E+ L N L E               Q   +    E++ 
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960

Query: 2149 LEFRVRELEQ--ALLVSADTFQKVEDRKHF-----GAVEAKPELSLEVQLQAERDAIDRK 2201
            L+  V ELE+    LV   T  + E RK +     GA +     S   +LQ   + +  K
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ---ELLKEK 2017

Query: 2202 EKEITNLEEQLEQFREELENKNEEVQQLH-MQLEIQKKESTTR--LQELEQENKLFKDDM 2258
            ++E+  L++   +++E++      V+ L  +Q E QK    T+  L +  +  K  + ++
Sbjct: 2018 QQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAEL 2077

Query: 2259 E--KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-----KIT 2311
               K+ L   +S+A      ++   K  ++   KE    Q+ ++   L+++L     K  
Sbjct: 2078 ASFKVLLDDTQSEAARVLADNLKLKK--ELQSNKESVKSQMKQKDEDLERRLEQAEEKHL 2135

Query: 2312 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2371
             + K ++EK + +R  +  +E  + + +     +++E++QL E ++    +LA   +  S
Sbjct: 2136 KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMS 2195

Query: 2372 M---NAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
                +   + +EA   + +    I  K   E+++    +  + +K+ L++ +  M +L  
Sbjct: 2196 SLQDDRDRVIDEAKKWERKFSDAIQSK---EEEIRLKEDNCSVLKDQLRQMSIHMEELKI 2252

Query: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPEL----------------EVVLTED 2472
             +  L+ +++  E              D L  +  EL                E+   E 
Sbjct: 2253 NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLES 2312

Query: 2473 ALKSLENQ-TYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI---KDMQEQ 2528
             LKSL++Q T   +  E  K    NLE  + Q E+ +        Q    +   +++  +
Sbjct: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSR 2372

Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
               E  M ++KI++L    EE +  A+      E  Q++ K  ++ + + S+ E  NI  
Sbjct: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIA-----ELRQQHDKEIKELENLLSQEEEENI-- 2425

Query: 2589 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL----EKEKKLL 2644
               + E+E    +     + ++L   +  +    I +K Q++   K++     ++++ + 
Sbjct: 2426 ---VLEEENKKAVD----KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478

Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
            + Q+L E +     EK++       E  K   E+       G  + ++ L +E+    AE
Sbjct: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEI------RGLRSHMDDLNSENAKLDAE 2532

Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA 2764
            L  Y+   E L + + +K++    L +   Q    L     KL    KE E   ++ +++
Sbjct: 2533 LIQYR---EDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRS 2589

Query: 2765 CMFEPLPIK---LSKSIASQTDGTLKISSSNQTPQILVKNAGIQINL---QSECSSEEVT 2818
              F  L  +   LSK I S     LK+S S  T Q+        + L   Q +   EEV 
Sbjct: 2590 --FNALQEEKQDLSKEIES-----LKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVH 2642

Query: 2819 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2878
             + + F+   +++ EL   E++ ++     +   ++ +    ++ L  + G ++   +  
Sbjct: 2643 RLSALFSSSQKRIAELE-EELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETA 2701

Query: 2879 RSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF--DIASEGRGEES-ESA 2935
              +    + ELA       +++            +    ++G    I S GR   S +++
Sbjct: 2702 EER----VAELARDLVEMEQKLL-----------MVTKENKGLTAQIQSFGRSMSSLQNS 2746

Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK 2995
             D   +++  L R       ++  L E    + E  ++  +SE          N++S L+
Sbjct: 2747 RDHANEELDELKRKYDASLKELAQLKEQGLLNRERDAL--LSETAFSMNSTEENSLSHLE 2804

Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTT 3055
             L  ++  + E  ++ SSQ  +S++              ++  S  +A+ + E       
Sbjct: 2805 KLNQQLLSKDEQLLHLSSQLEDSYNQ-------------VQSFSKAMASLQNERD----- 2846

Query: 3056 DAVGLLNCLEQ-RIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQES 3114
                L N LE+ R  E+G +  AA      A+ +SL    +A+ +  N R   LK  +  
Sbjct: 2847 ---HLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK---KAMSSLQNDRDRLLKELK-- 2898

Query: 3115 EKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE 3174
                      N+QQ+  Q+ +   EL  +K +  E Q++  + +++  EL+ E       
Sbjct: 2899 ----------NLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE------- 2941

Query: 3175 LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS 3234
                L  QH    EL   R+E                   K S E+     KE+  +  S
Sbjct: 2942 ---NLSWQH----ELHQLRME-------------------KSSWEIHERRMKEQYLMAIS 2975

Query: 3235 E-ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE-SQRMLYDAQLSEEQ 3292
            + ++    L++L   L S   +   L   ++ Q+Q   E+    + SQ ++Y+ +L   Q
Sbjct: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLK--VQYQRQASPETSASPDGSQNLVYETELLRTQ 3033

Query: 3293 GRNLELQVLLESEKVRIREMSSTLDR--ERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3350
              N  L+ + + E +RI++++S   +  E +    +Q  D T QS         L+E Q+
Sbjct: 3034 -LNDSLKEIHQKE-LRIQQLNSNFSQLLEEKNTLSIQLCD-TSQS---------LRENQQ 3081

Query: 3351 QLEE--KHSRIVE-LLNETEKYKLDSLQTRQQMEKDRQVHRKT----LQTEQEANTEGQK 3403
               +   H  ++E  + E +   L+        ++   VHRK+    L+  Q++ +E Q+
Sbjct: 3082 HYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQ 3141

Query: 3404 KMHELQSKVEDLQRQLEEKRQQ 3425
            ++   + +V +L++ LEE+R Q
Sbjct: 3142 QLCNTRQEVNELRKLLEEERDQ 3163



 Score =  225 bits (574), Expect = 6e-58
 Identities = 596/3013 (19%), Positives = 1245/3013 (41%), Gaps = 417/3013 (13%)

Query: 932  EVVEKDTTELMEKLEVTKREKLELSQRLS-DLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990
            E+ ++   E     +   +E+L  +++L  +L + ++QK  +   L ++ ++L++E++  
Sbjct: 33   ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQ---LQQKDEALQEERKAA 89

Query: 991  SLRCRELEIIINHNRAENVQSCDTQVSSLL--DGVVTMTSRGAEGSVSKVNKSFGEESKI 1048
              + ++L++   H +A+ + S +  +  +    G V  T   +E  +SK +KS  EE   
Sbjct: 90   DNKIKKLKL---HAKAK-LTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEME 145

Query: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108
            + + K   +        ++E+LI      +T+    +A QP+++    +E  ++K +  +
Sbjct: 146  IEKIKHKLQ--------EKEELISTLQAQLTQA---QAEQPAQSSTEMEEFVMMKQQLQE 194

Query: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLE 1168
                +   +  LS    T  +Q  + +  EKD       E  +   E+++  LQ + Q +
Sbjct: 195  KEEFISTLQAQLS---QTQAEQAAQQVVREKDARF----ETQVRLHEDEL--LQLVTQAD 245

Query: 1169 LQTMKTQETGDEGKPLH----LLIGKLQ---------KAVSEECSYFLQTLCSVLGEYYT 1215
            ++T   Q+     + L      L+G+ Q          A  +      Q L  +  E+ T
Sbjct: 246  VETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT 305

Query: 1216 PALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQT 1275
              L+  V  E +E+    + E  + E+ + +    + QE MH LL +  +       L++
Sbjct: 306  --LRNTVETEREESK--ILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361

Query: 1276 RLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK 1335
            R S +  +Q    ++E    ++   +     + S    L+D      SKL  LQD    K
Sbjct: 362  RYSAL--EQKHKAEMEEKTSHILSLQKTGQELQSACDALKD----QNSKL--LQD----K 409

Query: 1336 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL-----QAVSESTVPPSLPVDSVV 1390
             E+ VQ  +++     QQL++  Q    EI     RL     +  S+++ P      +  
Sbjct: 410  NEQAVQSAQTI-----QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQA 464

Query: 1391 ITESDAQRTMYPGSCVKKNIDGTIEFSG----EFGVKEE--TNIVKLLEKQYQE-QLEEE 1443
            +TE +   ++       +N  G +  S     E   + E  ++ + LLE Q +  + + E
Sbjct: 465  VTEENIA-SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523

Query: 1444 VAKVIVSMSIAFAQQTELSRISGGK---ENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500
            V+++ +   +  A +   S    G+   ENT S K      ++      EMK +Q++I F
Sbjct: 524  VSEISI---VDIANKRSSSAEESGQDVLENTFSQKH-----KELSVLLLEMKEAQEEIAF 575

Query: 1501 QTFETVDVKFKE---------EFKPLSKE----------LGEHGKEILLSNSDPHDIPE- 1540
               +    + +E         E K +  E          L + G++  L  ++   +P  
Sbjct: 576  LKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635

Query: 1541 -----SKDCVLTISEEMFSKDKTFIVRQSIHD-EISVSSMDASRQLMLNEEQLEDMRQEL 1594
                 S +     SEE+   D    ++ +  D + S+S++    Q   ++++LE ++ ++
Sbjct: 636  EKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC--HQDELERLKSQI 693

Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL---NRQLAQRSSIDNENLVSE 1651
            +       +A E+  + ++ +  ++  +  QL EE K+    N       S + + L+S+
Sbjct: 694  LELELNFHKAQEIYEK-NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752

Query: 1652 -RERVLLEELEA-LKQL--SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDR 1707
             +E  ++ EL A +KQL  +LA  E+     R    ++Q  ++N   +  +      ++ 
Sbjct: 753  VKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYESQTAHDN---LLTEQIHSLSIEA 805

Query: 1708 KPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSA 1767
            K +DV  E+L NE   +Q   +    ++  +       E  +      +   SSK +  +
Sbjct: 806  KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865

Query: 1768 SLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR 1827
              + + E E +    +  E  R  +    +    D    +I+    +TE+  +L++    
Sbjct: 866  QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISF--SMTEKMVQLNEEKFS 923

Query: 1828 SGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ 1887
                G EI    E+L  N+ SR + A ++ +E  +E SS L+      +   + S  + Q
Sbjct: 924  ---LGVEIKTLKEQL--NLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978

Query: 1888 EATESLKCQEELRER-LHEESRAREQLAVELSKAEGVIDGYADEKT----LFERQIQEKT 1942
               + LK + E R+R L      R++L   +S+ E  +    DE      L E +  E  
Sbjct: 979  HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038

Query: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEEREL-LSRQKEAMKAEAGPVEQQLLQETEKL 2001
            +  +  E    C +++ QE+E   +Q   E+E+ L   ++ ++ +    EQ   Q   K 
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQ--FQALVKQ 1096

Query: 2002 MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ 2061
            M + L+          D   Q+  L+ ++ E  +  I+     NT+  D    + AL K+
Sbjct: 1097 MNQTLQ----------DKTNQIDLLQAEISENQA-IIQKLITSNTDASD--GDSVALVKE 1143

Query: 2062 L-----------EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
                        E  +  L+E+ +  E E++  Q+++Q+     K + +     E   RE
Sbjct: 1144 TVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE 1203

Query: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKV 2170
                   LK++ D  + L    ++  ++ +   +++ +L+ +VRE     L S D  +  
Sbjct: 1204 ------ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESC 1257

Query: 2171 E-----DRKHFGAVE---AKPELSLEV---------------------QLQAERDAIDRK 2201
                  +   F A E    +P L   +                     Q++A+   I+ +
Sbjct: 1258 SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE 1317

Query: 2202 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-----LEIQKKESTTRLQELEQENKLFKD 2256
            + E   LE ++     EL  K+EEV QL  Q     LEI+  ++ +   E+  E+   K 
Sbjct: 1318 KVE---LELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL 1374

Query: 2257 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-KITTDNK 2315
            +  +L +A  E      ++      +  ++I +KE ++  L+ Q+++ +  L KI T+  
Sbjct: 1375 ESSQLQIAGLEH----LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE-- 1428

Query: 2316 VIEEKNELIRDLETQIECLMSDQE----------CVKRNREEEIEQLNEVIEKLQQEL-- 2363
             I E+ +LI+ L TQ+E    + +          C  + + EEI + +   +++Q++L  
Sbjct: 1429 -IIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487

Query: 2364 ANIGQKTSMNAH-SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422
            A I +K ++  + SL EE    +  ++ +      +E QV   N+E   +   L     +
Sbjct: 1488 ALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEE 1547

Query: 2423 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP----ELEVVLTEDALKSLE 2478
             ++L  E+     E +S+    S    S+ +A++ L++DK     E+E + +    +S E
Sbjct: 1548 RDKLITEMDRSLLENQSL----SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE 1603

Query: 2479 NQTYFKSFEENGK---GSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEM 2535
             Q   K  ++  +    S  N+     +++  V A   E  + Y +++  +   +   + 
Sbjct: 1604 WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQ 1663

Query: 2536 LQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED 2595
            LQ+    ++++ E+    A   Q ++  ++E      +N  + +E          +  E 
Sbjct: 1664 LQEAEQEMEEMKEKMRKFAKSKQQKILELEE------ENDRLRAEVHPAG-DTAKECMET 1716

Query: 2596 ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEK 2655
             L S+ S       ELE   V+M    + +K Q  ++EK+ L +E +  +L+  +EGN  
Sbjct: 1717 LLSSNASMK----EELER--VKMEYETLSKKFQSLMSEKDSLSEEVQ--DLKHQIEGNVS 1768

Query: 2656 KQREKEK-KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEK 2714
            KQ   E  ++      V +  T+      E     E ++L   +  T +E     + A  
Sbjct: 1769 KQANLEATEKHDNQTNVTEEGTQSIPGETE-----EQDSLSMSTRPTCSESVPSAKSANP 1823

Query: 2715 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKL 2774
               +       + +  + + Q+++ +A  +E+    + ++ ++  E++K  +   +  K 
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ--KNKEFSQTLENEKNTLLSQISTK- 1880

Query: 2775 SKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL 2834
                    DG LK+     T          ++NL ++   EE++        ++ K++E 
Sbjct: 1881 --------DGELKMLQEEVT----------KMNLLNQQIQEELS--------RVTKLKET 1914

Query: 2835 HAAEILDMESRHISETETLK----------REHYVAVQLLKEECGTLKAVIQCLRSKEGS 2884
               E  D+E R +++   L            +  +  +LL+ E   LK  +  L  ++  
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974

Query: 2885 SIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDS--FPKK 2942
             + E    ++   +E      G+    G      +  ++  E + E  +   D   + +K
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034

Query: 2943 IKGLLRAV------HNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKD 2996
            I  L R V        E  + L +T+   +   +H  +  +E  L   K  ++   S   
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAE--LASFKVLLDDTQSEAA 2092

Query: 2997 LITKMQLQREAEVYDSSQSHESFSDWRGE----LLLALQQVFLEERSVL---LAAFRTEL 3049
             +    L+ + E+  + +S +S    + E     L   ++  L+E+  +   L A R E 
Sbjct: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREK 2152

Query: 3050 TALGTT--DAVGLLNCLEQRIQE----------QGVEYQAAMECLQKADRRSLLSEIQAL 3097
              L  T  +    LN  ++ +Q+          Q   +  +M  LQ  DR  ++ E +  
Sbjct: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD-DRDRVIDEAKKW 2211

Query: 3098 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA----TELQEQ 3153
              + +    + + E   ++ +  +L+  ++Q    M E+++ +S ++       ++ Q +
Sbjct: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271

Query: 3154 LSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
            +  ++ V   L+ E  +   +LE T    H    EL     E+K   D++  L+++L   
Sbjct: 2272 VQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC 2331

Query: 3214 QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3273
            +++   L+  + +++A +  S+   ++   DL+ S E   + + ++N+  ++   LL+  
Sbjct: 2332 KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGK 2391

Query: 3274 QQKIE----SQRMLYDAQ-------LSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3322
            ++ I+      R  +D +       LS+E+  N+ L+   +    +  ++  TL   ++ 
Sbjct: 2392 EEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKE 2451

Query: 3323 HAQLQSS-DGTGQSRPPLPSE-DLLKELQKQLEEKHSRIV--------ELLNETEKYKLD 3372
            + Q ++  D   +S   L ++ D +    +QLEE+H  I+        E   E  K K +
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511

Query: 3373 SLQTRQQME----KDRQVHRKTLQTEQEAN------TEGQKKMHELQ----SKVEDLQRQ 3418
                R  M+    ++ ++  + +Q  ++ N         QK++ E+Q     ++E+   +
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAK 2571

Query: 3419 LEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTR 3478
            LEEK ++  + + + +R    +QE +KQ+L +E   ES ++    L    T +L  + T 
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQE-EKQDLSKE--IESLKVSISQLTRQVT-ALQEEGTL 2627

Query: 3479 NWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCV----ASKLQVLPQKAS 3534
                 Q    + KE    +L  +         ELE   ++L CV    A K+  +  K  
Sbjct: 2628 GLYHAQL---KVKEEEVHRLSALFSSSQKRIAELE---EELVCVQKEAAKKVGEIEDKLK 2681

Query: 3535 ERL------------QFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCG 3582
            + L            + ETA++     V E   +++   QKL     E   L +   S G
Sbjct: 2682 KELKHLHHDAGIMRNETETAEER----VAELARDLVEMEQKLLMVTKENKGLTAQIQSFG 2737

Query: 3583 SLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGA 3642
                 L          + +L  + +     + +L+EQ    R+  A    ++ FS+N   
Sbjct: 2738 RSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA-FSMN--- 2793

Query: 3643 NIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDS-LLQTLSPDSEHVTLKRI 3701
            + E    S  E  N++ L+  + L    +++     ++++ S  + +L  + +H+     
Sbjct: 2794 STEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL----- 2848

Query: 3702 YGKYLRAESFRKA 3714
               +   E FRK+
Sbjct: 2849 ---WNELEKFRKS 2858



 Score =  187 bits (475), Expect = 2e-46
 Identities = 454/2216 (20%), Positives = 888/2216 (40%), Gaps = 381/2216 (17%)

Query: 4    EERQKKLEAGKAKLAQFRQRKAQS-DGQSPSKKQKKKRKTSSSKHD-----VSAHHDLNI 57
            +E+ K+ E    +L Q + +  +S DG+ PS  Q++   ++    +        HH   +
Sbjct: 1220 DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279

Query: 58   DQSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSE 117
             +S     + + S+   +     S         EI + +    VELE ++S+T  + + +
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEK----VELELKVSSTTSELTKK 1335

Query: 118  VNGCSFVMRTGKPTNLLREEEFGVDDSYSEQG----------------AQDSPTHLEMME 161
                              EE F + +  ++QG                A+     LE  +
Sbjct: 1336 -----------------SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQ 1378

Query: 162  SELAGKQHEIEELNRELEEMR--VTYGTEGLQ----QLQEFEAA-------IKQRDGIIT 208
             ++AG +H + EL  +L+E++  ++   E +     QL E EAA       I +++ +I 
Sbjct: 1379 LQIAGLEH-LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIK 1437

Query: 209  QLTANLQQARREKDETMREF-LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK 267
             L   L+   +E DE +++  +EL E  QK +   ++ +A + ++    ++     L ++
Sbjct: 1438 ALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAA-----LISR 1492

Query: 268  QQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK 327
            ++ L   + L+E+   L   +   E  T  ++ ++ ++     E+D  +      + +E+
Sbjct: 1493 KEALKENKSLQEE---LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ-EER 1548

Query: 328  ETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL-ELTNSKQK 386
            + +I E++  ++E +  +    + L  A + L E +E++V++ + +K+ K+ E T  ++K
Sbjct: 1549 DKLITEMDRSLLENQSLSSSC-ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEK 1607

Query: 387  ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIV 446
             ++  +E + L+ + E +     +  Q   + V++ +QE   KL    A   E   +Q+ 
Sbjct: 1608 HKELQKEYEILLQSYENVSNEAER-IQHVVEAVRQEKQELYGKLRSTEANKKET-EKQLQ 1665

Query: 447  QMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL-MNVAINELNIKLQDT 505
            + +QE        MEEMK + +   ++  +    +    D+++  ++ A +     ++  
Sbjct: 1666 EAEQE--------MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717

Query: 506  NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK-----LNE 560
             S    +KEEL  +  E   L ++ + L+ E     E++Q  +  I    SK       E
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777

Query: 561  AHKSLSTV-EDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619
             H + + V E+    I   +E +  L +      +      E +   K+A     A S++
Sbjct: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCS------ESVPSAKSA---NPAVSKD 1828

Query: 620  AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679
                        SH+E  + L++  +++ RI   + +      + Q ++  +N +  +I 
Sbjct: 1829 ----------FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS 1878

Query: 680  TMQFEKDNL---ITKQNQL-------ILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729
            T   E   L   +TK N L       +  ++KLK+  +   +   E +  Q+ EL   I 
Sbjct: 1879 TKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI- 1937

Query: 730  ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLED 789
                     G   Q+V + Q+K ELLE +MK    +L++  ++LE E   L  EK     
Sbjct: 1938 ---------GNYCQDVTDAQIKNELLESEMK----NLKKCVSELEEEKQQLVKEK----- 1979

Query: 790  MLKIHTPVSQEERLIFLDSIKSKSKD---SVWEKEIEILIEENE----DLKQQCIQLNEE 842
                 T V  E R  +L+ I+   K+       KE++ L++E +     L++ CI+  E+
Sbjct: 1980 -----TKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034

Query: 843  IEKQRNTFSFAE-------KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895
            I     T    E       K+ E+  + L +      K + +L   K   +       + 
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094

Query: 896  LNEELHLQR---INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREK 952
            L + L L++    N  +VK +    DED     E  E   + EK    + EKL+  +REK
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK--KNMQEKLDALRREK 2152

Query: 953  LELSQRLSDLSEQLKQKHGEISFLNE--------------EVKSLKQEKEQVSLRCRELE 998
            + L + + ++   L +K  E+  L E               + SL+ ++++V    ++ E
Sbjct: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE 2212

Query: 999  IIIN---HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVS 1055
               +    ++ E ++  +   S L D +  M+    E    K+N S  E  K + E K  
Sbjct: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEE---LKINISRLEHDKQIWESKAQ 2269

Query: 1056 FENMTVGEESKQEQLILDHLPSVTKE--SSLRATQ----PSEND--KLQKELNVLKSEQN 1107
                    E + +Q + D L    KE  S L  T+     S+N+  KL+ EL  LK +  
Sbjct: 2270 -------TEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLT 2322

Query: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL 1167
            DL   +E    C     +      ++  + +  K      E  + A  E    L +   +
Sbjct: 2323 DLSNSLEK---CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379

Query: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
            + Q + +  +G E + + + I +L++   +E    L+ L S   E      +    A DK
Sbjct: 2380 KEQKIISLLSGKE-EAIQVAIAELRQQHDKEIKE-LENLLSQEEEENIVLEEENKKAVDK 2437

Query: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287
             N      +    E    + ++  F ++M +L N           L+ R   I  ++   
Sbjct: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL 2497

Query: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHK--------SKLSSLQDLEKTKLEE- 1338
            ++    E N  KEE   L  H    N E+  ++ +        +++ +++D ++ +L E 
Sbjct: 2498 IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV 2557

Query: 1339 ---QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESD 1395
               Q +ELE+  + L+++LKE+E+  E     L++   A+ E     S  ++S+ ++ S 
Sbjct: 2558 QLQQNKELENKYAKLEEKLKESEEANED----LRRSFNALQEEKQDLSKEIESLKVSISQ 2613

Query: 1396 AQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAF 1455
              R +             ++  G  G+      VK          EEEV ++    S + 
Sbjct: 2614 LTRQV-----------TALQEEGTLGLYHAQLKVK----------EEEVHRLSALFSSSQ 2652

Query: 1456 AQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFK 1515
             +  EL       +  A+ K    V + E     E+K      G    ET     +E   
Sbjct: 2653 KRIAELEEELVCVQKEAAKK----VGEIEDKLKKELKHLHHDAGIMRNETETA--EERVA 2706

Query: 1516 PLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMD 1575
             L+++L E  +++L+         E+K   LT   + F +              S+SS+ 
Sbjct: 2707 ELARDLVEMEQKLLMVTK------ENKG--LTAQIQSFGR--------------SMSSLQ 2744

Query: 1576 ASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
             SR    NEE       EL R+Y            A ++++  Q ++Q  L  E   L  
Sbjct: 2745 NSRD-HANEE-----LDELKRKY-----------DASLKEL-AQLKEQGLLNRERDALLS 2786

Query: 1636 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV 1695
            + A   +   EN +S  E++  + L   +QL       L  +L +S  Q Q+ ++    +
Sbjct: 2787 ETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL-----HLSSQLEDSYNQVQSFSKAMASL 2841

Query: 1696 E---EQTFKEKELDRK-----------PEDVPPEI--LSNERYALQKANNRLLKILLEVV 1739
            +   +  + E E  RK           P   P E+  L     +LQ   +RLLK L  + 
Sbjct: 2842 QNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ 2901

Query: 1740 KTTAAVEETIGR-HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
            +    + + I   H L    +  + ++ A  I + E      S  HE H           
Sbjct: 2902 QQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELH----------- 2950

Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQ--AAVEK 1856
                  R + + W        E+ +R ++            E+ ++ IS + Q  + ++ 
Sbjct: 2951 ----QLRMEKSSW--------EIHERRMK------------EQYLMAISDKDQQLSHLQN 2986

Query: 1857 LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE-LRERLHEESRAREQLAV 1915
            L+  +  +SSQ +  KV              + +++L  + E LR +L++  +   Q  +
Sbjct: 2987 LIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL 3046

Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
             + +         +EK     Q+ + +  +   +Q      N    LE + Q++Q     
Sbjct: 3047 RIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQ----- 3101

Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
                       AGP+               ++V   A + ++ + +  K+   ++ E   
Sbjct: 3102 -----------AGPL--------------NIDVAPGAPQEKNGVHR--KSDPEELREPQQ 3134

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091
             F E +Q    +L + RQ+   L K LE+ R    +Q +  E+   V +++I++LE
Sbjct: 3135 SFSEAQQ----QLCNTRQEVNELRKLLEEER----DQRVAAENALSVAEEQIRRLE 3182



 Score =  121 bits (304), Expect = 1e-26
 Identities = 230/1172 (19%), Positives = 497/1172 (42%), Gaps = 183/1172 (15%)

Query: 2    EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHH-DLNIDQS 60
            +DE+ +++LE  + K    +++K   +     +++K   + +  +  V+ +  D  + Q 
Sbjct: 2119 KDEDLERRLEQAEEK--HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176

Query: 61   QCNEMYINSSQRVESTVIPESTIMRTLHS---------GEITSHEQGFSVELES---EIS 108
            Q N         ++STV   +   +++ S          E    E+ FS  ++S   EI 
Sbjct: 2177 QEN---------LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227

Query: 109  TTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQ----DSPTHLEMMESEL 164
               D+CS        V++       +  EE  ++ S  E   Q     + T +++ +   
Sbjct: 2228 LKEDNCS--------VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVC 2279

Query: 165  AGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDET 224
               Q E +EL  +LEE R  Y +    +L + E+ +K     +T L+ +L++ + +K   
Sbjct: 2280 DTLQGENKELLSQLEETRHLYHSSQ-NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL 2338

Query: 225  MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT--HQQQLEEQDH 282
                 +     Q  +  ++QL+                 LQA +++ +  H++   ++  
Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETD---------------LQASRELTSRLHEEINMKEQK 2383

Query: 283  LLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEE 342
            ++     K+E   + I+ L+++      ++ K++EN   +E +E+  ++EE N K ++  
Sbjct: 2384 IISLLSGKEEAIQVAIAELRQQ----HDKEIKELENLLSQE-EEENIVLEEENKKAVD-- 2436

Query: 343  KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVE 402
             KT +L + L T  K   E  +Q  Q +  +K+M     +S Q +R       +++G  +
Sbjct: 2437 -KTNQLMETLKTIKK---ENIQQKAQLDSFVKSM-----SSLQNDRD------RIVGDYQ 2481

Query: 403  ELQKRNHKDSQFETDIVQRMEQETQRKLEQ---LRAELDEMYGQ------QIVQMKQELI 453
            +L++R+      +  ++Q    E  +  E+   LR+ +D++  +      +++Q +++L 
Sbjct: 2482 QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541

Query: 454  R------QHMAQMEEMKTRHKGEMENA-LRSYSNITVNEDQIKLMNVAINELNIKLQDTN 506
            +          Q+ E++ +   E+EN   +    +  +E+  + +  + N L  + QD +
Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601

Query: 507  SQKEKLKEELGLILEEKCALQRQ--LEDLVEELSFSREQIQRARQTIAEQESKLNEAHKS 564
             + E LK  +  +  +  ALQ +  L     +L    E++ R     +  + ++ E  + 
Sbjct: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661

Query: 565  LSTVEDLKAEIVSASESRKELELKH----------EAEVTNYKI------------KLEM 602
            L  V+   A+ V   E + + ELKH          E E    ++            KL M
Sbjct: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721

Query: 603  LEKEKNAVLDRMAESQEAELERLRTQLLFSHEE--ELSK-----LKEDLEIEHRINIEKL 655
            + KE N  L    +S    +  L+     ++EE  EL +     LKE  +++ +  + + 
Sbjct: 2722 VTKE-NKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE 2780

Query: 656  KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715
            +D L       ++  +      +E +      L++K  QL+   S+L+D   + V S S+
Sbjct: 2781 RDALLSETAFSMNSTEENSLSHLEKL---NQQLLSKDEQLLHLSSQLED-SYNQVQSFSK 2836

Query: 716  EMTLQINE---LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQ 772
             M    NE   L  E+E  R+ E+ K     +      + + L+K M   +ND       
Sbjct: 2837 AMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND------- 2889

Query: 773  LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 832
                + +LK+ K   +  L+I+  +++      L  +K++ ++  ++ + +      E+L
Sbjct: 2890 ---RDRLLKELKNLQQQYLQINQEITE------LHPLKAQLQE--YQDKTKAFQIMQEEL 2938

Query: 833  KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLEDSKNK-QELEYK 890
            +Q+ +    E+ + R      + ++E++ + ++E+Y   +  KD  L   +N  +EL   
Sbjct: 2939 RQENLSWQHELHQLR----MEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS 2994

Query: 891  SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
            S      +  + ++ +P T    S+  D  +  V ET       E   T+L + L+   +
Sbjct: 2995 SSQTQPLKVQYQRQASPET----SASPDGSQNLVYET-------ELLRTQLNDSLKEIHQ 3043

Query: 951  EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 1010
            ++L + Q  S+ S+ L++K+     L +  +SL++ ++           ++NH      Q
Sbjct: 3044 KELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG-------DLLNHCAVLEKQ 3096

Query: 1011 SCDTQVSSLLDGVVTMTSRGAEG--------SVSKVNKSFGEESKIMVEDKVSFENM-TV 1061
              + Q   L   V     +   G         + +  +SF E  + +   +     +  +
Sbjct: 3097 VQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKL 3156

Query: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSEND 1093
             EE + +++  ++  SV +E  +R  + SE D
Sbjct: 3157 LEEERDQRVAAENALSVAEE-QIRRLEHSEWD 3187



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 119/591 (20%), Positives = 239/591 (40%), Gaps = 64/591 (10%)

Query: 3123 EYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQ 3182
            + N++      L  + ++        ++QE+L+  + +V ELK  + Q  ++L+   +A 
Sbjct: 23   DQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL 82

Query: 3183 HKHLK----ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD 3238
             +  K    +++  +L  K K   ++   + + ++       +   E++ +K  +S   +
Sbjct: 83   QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142

Query: 3239 KEELEDLKFSLESQKQ--RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3296
            + E+E +K  L+ +++    LQ  L   Q +Q    S +  E   M    Q  EE    L
Sbjct: 143  EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202

Query: 3297 ELQV----LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL 3352
            + Q+      ++ +  +RE  +  + +  LH   +      Q+      +  L+ LQ++L
Sbjct: 203  QAQLSQTQAEQAAQQVVREKDARFETQVRLHED-ELLQLVTQADVETEMQQKLRVLQRKL 261

Query: 3353 EEK------HSRIVELLNE----TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN---- 3398
            EE        +++V+LL +     E+      Q  QQME +    R T++TE+E +    
Sbjct: 262  EEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321

Query: 3399 -------TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451
                    E +   H LQ ++  L  Q E+  Q   +L+     L+      QK + E E
Sbjct: 322  EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE------QKHKAEME 375

Query: 3452 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHE 3511
            EK      L +   E  +         + +LQ K E   + +   + +E           
Sbjct: 376  EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE----------- 424

Query: 3512 LEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQK-LTGQQGE 3570
             + ++QK + ++  L  LP +  E     +  D      Q   +E I  LQK +   + E
Sbjct: 425  -DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE 483

Query: 3571 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGR 3630
            + +L+  S       E L  +N +L+  I+ L     + +N   + + ++          
Sbjct: 484  KGALLLSSIE----LEELKAENEKLSSQITLL-----EAQNRTGEADREVSEISIVDIAN 534

Query: 3631 DNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELR 3681
              SS    +G   +E   + +    ++E   L   +K A+ E+  LK +L+
Sbjct: 535  KRSSSAEESGQDVLENTFSQK----HKELSVLLLEMKEAQEEIAFLKLQLQ 581



 Score = 33.9 bits (76), Expect = 3.3
 Identities = 64/324 (19%), Positives = 124/324 (38%), Gaps = 56/324 (17%)

Query: 3364 NETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKR 3423
            ++T++     L      E D + +  T +  QE     ++ + EL+  +     QL++K 
Sbjct: 20   DDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQK- 78

Query: 3424 QQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQ 3483
                                  + L+ E K    +I    L+      LTS     ++ +
Sbjct: 79   ---------------------DEALQEERKAADNKIKKLKLHAKA--KLTS--LNKYIEE 113

Query: 3484 QKIEG----ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ----CVASKLQVLPQKASE 3535
             K +G     T+  +  +L + +   T    E+E I+ KLQ     +++    L Q  +E
Sbjct: 114  MKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAE 173

Query: 3536 RLQFETADDEDFIWVQENI---DEIILQLQ-KLTGQQGEEPSLVSPSTSCGSLTERLLRQ 3591
            +    + + E+F+ +++ +   +E I  LQ +L+  Q E+ +             ++   
Sbjct: 174  QPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLH 233

Query: 3592 NAELTGHISQL---TEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAII 3648
              EL   ++Q    TE +  LR +  KLEE                  SL G A +  ++
Sbjct: 234  EDELLQLVTQADVETEMQQKLRVLQRKLEEH---------------EESLVGRAQVVDLL 278

Query: 3649 ASEKEVWNREKLTLQKSLKRAEAE 3672
              E     +    L + L++ EAE
Sbjct: 279  QQELTAAEQRNQILSQQLQQMEAE 302


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  285 bits (728), Expect = 8e-76
 Identities = 613/3005 (20%), Positives = 1254/3005 (41%), Gaps = 421/3005 (14%)

Query: 170  EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFL 229
            E+EE  R   E++     +  Q L +  A +  RD    Q ++++   ++EK  +     
Sbjct: 174  EVEERKRLEAEVKALQAKKASQTLPQ--ATMNHRDIARHQASSSVFSWQQEKTPS----- 226

Query: 230  ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQK 289
             L+  SQ+  I+ +   AS        + + + L   K+   +         HLL+  + 
Sbjct: 227  HLSSNSQRTPIR-RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285

Query: 290  KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK 349
            + ++   +I+ L+ +++ +E E   +V      + QE +  +E+   ++IE+EK   + +
Sbjct: 286  QNQELRNKINELELRLQGHEKEMKGQVN-----KFQELQLQLEKAKVELIEKEKVLNKCR 340

Query: 350  DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409
            D+L        +   +     Q++K    +LT     +RQ++E  +    ++E+  K   
Sbjct: 341  DELVRTTAQYDQASTKYTALEQKLK----KLTEDLSCQRQNAESARC---SLEQKIKEKE 393

Query: 410  KDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKG 469
            K+ Q E    QR  Q   ++  Q++A L      Q +Q  + +     A+++++ T  K 
Sbjct: 394  KEFQEELSRQQRSFQTLDQECIQMKARLT-----QELQQAKNMHNVLQAELDKL-TSVKQ 447

Query: 470  EMENALRSYSNITVNEDQ-IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
            ++EN L  +       +Q  +   +  NEL   +++   +   LK        E C L+ 
Sbjct: 448  QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507

Query: 529  QLEDLVEELSFSREQIQRARQTIAEQES-------KLNEAHKSLSTVEDLKAEIVSASES 581
            +L+++ + L+ S+   +  +     QE+       K+N+   SL T+E LK  +    + 
Sbjct: 508  ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL-TLEKLKLAVADLEKQ 566

Query: 582  R---KELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ-LLFS-HEEE 636
            R   ++L  K E  +     KL   EKE  A+L  + E ++ E E L+ +  LFS  + E
Sbjct: 567  RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL-ELKKKEYEELKEEKTLFSCWKSE 625

Query: 637  LSKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLITKQNQL 695
              KL   +E E + N++   ++L    K QQI    +E ++++ T++ +++NL  +   L
Sbjct: 626  NEKLLTQMESE-KENLQSKINHLETCLKTQQIK--SHEYNERVRTLEMDRENLSVEIRNL 682

Query: 696  ILEISKLKDLQQSLVNSKSEEMTLQ---INELQKEIEILRQEEKEK--------GTLEQE 744
                        ++++SKS E+  Q     ELQ++ E   Q+ +++          L  +
Sbjct: 683  -----------HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731

Query: 745  VQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL---EDMLKIHTPVSQEE 801
            V++L+ K +LL  ++ +K+   Q+  A+ E+   +LK +  +L   ED  +      Q+ 
Sbjct: 732  VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQP 791

Query: 802  RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
             +    +     + S+  +  E  +E ++  K   I     ++ + ++  F+ ++ +   
Sbjct: 792  AMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMN 846

Query: 862  QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921
             +LQ++   L+++K ++E++  K E  ++S +   +     QRI+    K++       +
Sbjct: 847  SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS-----QRIS----KLQEDT-SAHQ 896

Query: 922  TFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVK 981
              VAETL   E  EK+   L +K+E  + E  EL +    L + LK    E+  L+E + 
Sbjct: 897  NVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK----ELQLLSETLS 952

Query: 982  SLKQEKEQ-VSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGVVTMTS--RGAEGSVS 1036
              K+E    +SL  RE+E +   N    E   S + +  +L+    +  +     E S+S
Sbjct: 953  LEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS 1012

Query: 1037 KVNKSFGEESKIMVE---------DKVSFENMTVGEESKQEQLILDHLPSVTKE-----S 1082
            +++  + +E  I+++         + +S +     E++ + + +L+   S+ +       
Sbjct: 1013 ELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELE 1072

Query: 1083 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142
             L+     E+ +   +L   +    +L L++E  +  L         ++ +   N K +A
Sbjct: 1073 QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR-------SEMTDNQNNSKSEA 1125

Query: 1143 LCSLKEELIFAQEEK---IKELQKIHQLELQTMKTQETGD-----EGKPLHLLIGKLQKA 1194
               LK+E++  +EE+    KE+  + Q   Q MK  +T       E +P+   + K +++
Sbjct: 1126 -GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV-KERES 1183

Query: 1195 VSEECSYFLQTLCSV----LGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQ 1250
               +C++  Q    V    L  Y    ++ E    +KE       +  + E +  ++E+Q
Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELK----LQESEKEKECLQHELQ 1239

Query: 1251 DFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQ 1310
              + ++ T                + L  +  Q+  G+K    +  +  EE      H  
Sbjct: 1240 TIRGDLET----------------SNLQDMQSQEISGLK----DCEIDAEEKYISGPHEL 1279

Query: 1311 MTNLED---IDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHC 1367
             T+  D   +  + ++ ++ L +LEK     Q ++ E L++ L     E        I  
Sbjct: 1280 STSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYE-LVTELNDSRSEC-------ITA 1331

Query: 1368 LQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETN 1427
             +K  + V +        ++ V I   D+   +  G  V+    G  EF  +   +   +
Sbjct: 1332 TRKMAEEVGKL-------LNEVKILNDDS--GLLHGELVEDIPGG--EFGEQPNEQHPVS 1380

Query: 1428 IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHY 1487
            +  L E    E L   ++   V M  A  Q+  L            S Q+      +QH 
Sbjct: 1381 LAPLDESNSYEHL--TLSDKEVQMHFAELQEKFL------------SLQSEHKILHDQHC 1426

Query: 1488 FNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLT 1547
                K+S+ Q    + +  ++      +      G+  KE+ L   +      S  CV  
Sbjct: 1427 QMSSKMSELQTYVDSLKAENLVLSTNLRNFQ---GDLVKEMQLGLEEGLVPSLSSSCVPD 1483

Query: 1548 ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATEL 1607
             S      D +F   +++ ++    S+ ++ +  ++  Q   + +      QE     + 
Sbjct: 1484 SSSLSSLGDSSFY--RALLEQTGDMSLLSNLEGAVSANQC-SVDEVFCSSLQEENLTRKE 1540

Query: 1608 LRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS 1667
               A  + +E      E  ++ +++L  ++  +  + N            +E++ L+QL 
Sbjct: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKN------------KEIQELEQLL 1588

Query: 1668 LAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA 1727
             + R++L C       + Q  +EN+   ++ T    E++ K              A +K 
Sbjct: 1589 SSERQELDC------LRKQYLSENEQWQQKLTSVTLEMESK-------------LAAEKK 1629

Query: 1728 NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSC-VHEE 1786
                L + LEV +      +   R +LGI        +  ++  R+E      SC + +E
Sbjct: 1630 QTEQLSLELEVARLQLQGLDLSSRSLLGI-------DTEDAIQGRNE------SCDISKE 1676

Query: 1787 HTRVTDESIPSYSGSDM----PRNDINM-WSKVTEEGTELSQRLVRSGFAGTEIDPENEE 1841
            HT  T E  P +    +     + D+N+   K+TE G      +  +G    E  P+   
Sbjct: 1677 HTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGA-----VKPTGECSGEQSPDT-- 1729

Query: 1842 LMLNISSRLQAAVEKLLEAISETSSQLEHAKV------TQTELMRESFRQKQEATESLKC 1895
               N     +   +   E ISE S    +A V       Q ++     R K+ + E+L+ 
Sbjct: 1730 ---NYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRL 1786

Query: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
               + +R     R  E L  E+ + +  +        L E Q+  K +    LE+     
Sbjct: 1787 LHVIEDR----DRKVESLLNEMKELDSKLH-------LQEVQLMTKIEACIELEK----- 1830

Query: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK- 2014
               + EL+ E   + E+ E  S              Q+LLQ  E       +++  A+K 
Sbjct: 1831 --IVGELKKENSDLSEKLEYFSCD-----------HQELLQRVETSEGLNSDLEMHADKS 1877

Query: 2015 VRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ---LEKMRKFLDE 2071
             R+D+   V  +    +E   RF+++E     EL  +R +  ++E +   LE   + +  
Sbjct: 1878 SREDIGDNVAKVNDSWKE---RFLDVE----NELSRIRSEKASIEHEALYLEADLEVVQT 1930

Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVV--PRFQPISE-----HQTREVEQLANHLKEKTDK 2124
            + +  E + +  Q+ I  LE++L VV   R Q   E      +T  ++QL+  +KEKT +
Sbjct: 1931 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1990

Query: 2125 C----SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVE 2180
                 SE L   +  + +++E+ E ++ L   V EL   L       +K++  +      
Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSEL---LKDKTHLQEKLQSLEKDSQAL 2047

Query: 2181 AKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE---IQK 2237
            +  +  LE Q+     A   KEKE+  L ++ E  +  L   + E   +   LE   ++K
Sbjct: 2048 SLTKCELENQI-----AQLNKEKEL--LVKESESLQARLSESDYEKLNVSKALEAALVEK 2100

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
             E   RL   ++E    +  +EKL + I   +A   +  H+     A+ ++E+E E D L
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRI---EADEKKQLHI-----AEKLKERERENDSL 2152

Query: 2298 NEQVTKLQQQLKITTDNKVI-----EEKNELIRDLETQIECLMSDQECVKRN---REEEI 2349
             ++V  L+++L+++ +N+ +     E     +  L+TQIE +    +  + +      E 
Sbjct: 2153 KDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK 2212

Query: 2350 EQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-----ALEQQVET 2404
            E L + I++ Q +L+ +  K   +  SL EE    K Q ++ I E+       L+ Q++ 
Sbjct: 2213 ENLTKQIQEKQGQLSEL-DKLLSSFKSLLEE----KEQAEIQIKEESKTAVEMLQNQLKE 2267

Query: 2405 ANEEMTFM---KNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2461
             NE +  +   + ++K T   ++   +E   L+   E +       E      +  L + 
Sbjct: 2268 LNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKES 2327

Query: 2462 KPELEVV--LTEDALKSLE----NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLEL 2515
            +   +++    E+  + LE    NQ +     EN KG +  L+ ++  +  ++   +L++
Sbjct: 2328 EHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDV 2387

Query: 2516 TQCYKQIKDMQEQGQFETEMLQK-KIVN------LQKIVEEKVAAALVSQIQLEAVQEYA 2568
                 + +++  + Q E E + + +I+N      LQ+  +EKV     S   +E +Q   
Sbjct: 2388 VTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL 2447

Query: 2569 KFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQ 2628
            K  + N+ +++     N Q   + +E  L S +  L L  ++L   + E   + I+ +  
Sbjct: 2448 K--ELNERVAA---LHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502

Query: 2629 VEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK-KRSPQDVEVLKTTTELFHSNEESGF 2687
            V    + V + ++KL          EKK  E  + K   QD E L +         +   
Sbjct: 2503 VNGLIQEVEDGKQKL----------EKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2552

Query: 2688 FNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVR-DHLAEAKEK 2746
               LE LR  +V  + ++   + K   LQ+ L V +++  +L+ +L   + D ++  ++ 
Sbjct: 2553 EQNLE-LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKV 2611

Query: 2747 LSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI------SSSNQTPQILVK 2800
              +  KE E + +  + A     L  +LS    ++  G L++      SS +Q  ++ ++
Sbjct: 2612 NKMTAKETELQREMHEMAQKTAELQEELSGE-KNRLAGELQLLLEEIKSSKDQLKELTLE 2670

Query: 2801 NAGIQINLQSECSSE-----EVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKR 2855
            N+ ++ +L      +     +V E I+++  ++ + ++ H A +LD   ++  E +T + 
Sbjct: 2671 NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730

Query: 2856 EHYVAVQLLKEEC-GTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIY 2914
            +        KEEC  + K  I  L+S +     E  ++    T +I      +      Y
Sbjct: 2731 K-----LTSKEECLSSQKLEIDLLKSSK-----EELNNSLKATTQILEELKKTKMDNLKY 2780

Query: 2915 LTHSQGFDIASEGR-------GEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSD 2967
            +   +  +  ++G+        ++ E   +   K++  L  A   +    +  T+     
Sbjct: 2781 VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELT 2840

Query: 2968 GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSH----ESFSDWR 3023
             E   +++  E   +E   Y++   SL  LI+  +L++  E+ ++  +H    +S  D R
Sbjct: 2841 TEIKELKETLEEKTKEADEYLDKYCSL--LISHEKLEKAKEMLETQVAHLCSQQSKQDSR 2898

Query: 3024 GELLL 3028
            G  LL
Sbjct: 2899 GSPLL 2903



 Score =  213 bits (542), Expect = 3e-54
 Identities = 612/3148 (19%), Positives = 1248/3148 (39%), Gaps = 533/3148 (16%)

Query: 501  KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ---TIAEQESK 557
            K+Q+   Q +KLK+E       K   Q QL+ L   L   +++++  +     +  +  +
Sbjct: 19   KIQELEGQLDKLKKE-------KQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQR 71

Query: 558  LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM--- 614
            L E  +SL   +   +  +   ES+   +   E ++ + K ++E LE+E       +   
Sbjct: 72   LMEICESLEKTKQKISHELQVKESQVNFQ---EGQLNSGKKQIEKLEQELKRCKSELERS 128

Query: 615  ---AESQEAELERLRT-QLLFS-------------HEEELSKLKEDLEIEHRINIE---- 653
               A+S +  L    T Q +F+             +E+   K  +++E   R+  E    
Sbjct: 129  QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKAL 188

Query: 654  ---KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710
               K    L        D  +++ S  + + Q EK       N     I +  D   S  
Sbjct: 189  QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR--DFSASYF 246

Query: 711  NSKSE----EMTLQINELQKEIE---------ILRQEEKEKGTLEQEVQELQLKTELLEK 757
            + + E      TLQI +               +L Q + +   L  ++ EL+L+ +  EK
Sbjct: 247  SGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEK 306

Query: 758  QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK--IHTPVSQEERLIFLDSIKSKSKD 815
            +MK + N  QE   QLE     L +++K L       + T    ++      +++ K K 
Sbjct: 307  EMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLK- 365

Query: 816  SVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL-LKV 874
                K  E L  + ++ +     L ++I+++   F       + ++Q L +E   +  ++
Sbjct: 366  ----KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARL 421

Query: 875  KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV- 933
              +L+ +KN   +  +++L  L      Q++     + K  +   ++ F A  ++  E+ 
Sbjct: 422  TQELQQAKNMHNV-LQAELDKLTSVK--QQLENNLEEFKQKLCRAEQAFQASQIKENELR 478

Query: 934  -----VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKE 988
                 ++K+   L    E   RE   L   L ++ + L Q         EE+K+ K   +
Sbjct: 479  RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN----FAEEMKA-KNTSQ 533

Query: 989  QVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE--S 1046
            +  LR  + +I    N+ EN  + +    ++ D       R     + K  +   E+   
Sbjct: 534  ETMLRDLQEKI----NQQENSLTLEKLKLAVAD---LEKQRDCSQDLLKKREHHIEQLND 586

Query: 1047 KIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQ 1106
            K+   +K S   ++  E  K+E         + +E +L +   SEN+KL   L  ++SE+
Sbjct: 587  KLSKTEKESKALLSALELKKKEY------EELKEEKTLFSCWKSENEKL---LTQMESEK 637

Query: 1107 NDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEEL---------IFAQEEK 1157
             +L+ ++     CL         Q++ +  NE+ + L   +E L         +   +  
Sbjct: 638  ENLQSKINHLETCLK------TQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV 691

Query: 1158 IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPA 1217
              E QK+  +ELQ  +  E  D+         K QK +   C    Q    V        
Sbjct: 692  EVETQKLAYMELQ--QKAEFSDQ---------KHQKEIENMCLKTSQLTGQV-------- 732

Query: 1218 LKCEVNAEDKENSGDYISE---NEDPELQDYRYEVQDFQENMHTL-LNKVTEE------- 1266
                   ED E+    +S    ++D   QD   E +  ++ + +   + VT E       
Sbjct: 733  -------EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLL 785

Query: 1267 -YNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKL 1325
             +++   +    + I G+Q   M  E  E  L  +++   S   Q   ++ ++ + +S+ 
Sbjct: 786  AFDQQPAMHHSFANIIGEQ-GSMPSERSECRLEADQSPKNSAILQ-NRVDSLEFSLESQK 843

Query: 1326 SSLQDLEKT---------KLEEQVQELE----SLISSLQQQLKETEQNYEAEIHCLQKRL 1372
                DL+K          ++EE + + E    S ++   Q++ + +++  A  + + + L
Sbjct: 844  QMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETL 903

Query: 1373 QAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGV--KEETNIVK 1430
             A+        L  D V   +++ Q        ++ ++      S    +  KE ++I+ 
Sbjct: 904  SALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIIS 963

Query: 1431 LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNE 1490
            L +++ +E  +E      ++ S+   ++  L + S    N    ++       +Q+   +
Sbjct: 964  LNKREIEELTQENGTLKEINASLN-QEKMNLIQKSESFANYIDEREKSISELSDQYKQEK 1022

Query: 1491 MKLSQ--DQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTI 1548
            + L Q  ++ G   +E +  K+K   +  SK       E LL+      + E++   L  
Sbjct: 1023 LILLQRCEETG-NAYEDLSQKYKAAQEKNSK------LECLLNECT--SLCENRKNELEQ 1073

Query: 1549 SEEMFSKD-KTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATEL 1607
             +E F+K+ + F+ + +  +E        ++ LML   +LE ++Q L  +  ++Q  ++ 
Sbjct: 1074 LKEAFAKEHQEFLTKLAFAEE-------RNQNLML---ELETVQQALRSEMTDNQNNSKS 1123

Query: 1608 LRQAHMRQMERQREDQEQLQEEIKRL---NRQLAQ--RSSIDNENLVSERERVLLEELEA 1662
                  +++   +E+Q ++Q+E+  L   N QL +  ++  + +NL SE  R  ++E E+
Sbjct: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES 1183

Query: 1663 LKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERY 1722
             +      + ++  E++  S  + N    Q E      + KEL  +  +   E L +E  
Sbjct: 1184 ERN-QCNFKPQMDLEVKEISLDSYNAQLVQLEA---MLRNKELKLQESEKEKECLQHE-- 1237

Query: 1723 ALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSC 1782
             LQ     L          T+ +++   + + G+ D               +AE    S 
Sbjct: 1238 -LQTIRGDL---------ETSNLQDMQSQEISGLKD------------CEIDAEEKYISG 1275

Query: 1783 VHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL 1842
             HE  T   D +    S      N +N   K+ E        LV      TE++    E 
Sbjct: 1276 PHELSTSQNDNAHLQCS-LQTTMNKLNELEKICEILQAEKYELV------TELNDSRSEC 1328

Query: 1843 MLNISSRLQAAVEKLLEAIS--ETSSQLEHAKVTQTELMRESFRQKQEATE-SLKCQEEL 1899
             +  + ++   V KLL  +      S L H ++ +     E   Q  E    SL   +E 
Sbjct: 1329 -ITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDES 1387

Query: 1900 RERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ------EKTDIIDRLEQELL 1953
                H     +E         E  +   ++ K L ++  Q      E    +D L+ E L
Sbjct: 1388 NSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENL 1447

Query: 1954 CASNRLQELEAE---QQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010
              S  L+  + +   + Q+  E  L+     ++ +   P    L    +      L  Q 
Sbjct: 1448 VLSTNLRNFQGDLVKEMQLGLEEGLVP----SLSSSCVPDSSSLSSLGDSSFYRALLEQT 1503

Query: 2011 QAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTE--------LMDLRQQNQALEKQL 2062
                +  +L+  V A +  V+E     ++ E     E        + +L    +   + L
Sbjct: 1504 GDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSL 1563

Query: 2063 EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ---------TREVEQ 2113
            EK+ + ++ Q I +  E    +Q +    Q+L  + R Q +SE++         T E+E 
Sbjct: 1564 EKLEEKMESQGIMKNKEIQELEQLLSSERQELDCL-RKQYLSENEQWQQKLTSVTLEMES 1622

Query: 2114 LANHLKEKTDKCS-ELLLSKEQLQR-DIQERNEEIEKLEFRVRELEQALLVSADTFQKVE 2171
                 K++T++ S EL +++ QLQ  D+  R+      E  ++   ++  +S +   +  
Sbjct: 1623 KLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETT 1682

Query: 2172 DR--KH----FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEE 2225
            +R  KH        +A+ +L+L+++   E  A+ +   E +  +     +    E+K + 
Sbjct: 1683 ERTPKHDVHQICDKDAQQDLNLDIEKITETGAV-KPTGECSGEQSPDTNYEPPGEDKTQG 1741

Query: 2226 VQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG---K 2282
              +   +L      +   +  L  +     +D+  L L +KE+   + +  HV+     K
Sbjct: 1742 SSECISELSFSGPNALVPMDFLGNQ-----EDIHNLQLRVKETSNENLRLLHVIEDRDRK 1796

Query: 2283 FAQIIQEKEVEIDQLNEQVTKLQQQLK-----------ITTDNKVIEEK--------NEL 2323
               ++ E +    +L+ Q  +L  +++           +  +N  + EK         EL
Sbjct: 1797 VESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQEL 1856

Query: 2324 IRDLETQIECLMSDQE--CVKRNREEEIEQLNEVIEKLQQELANIGQKTSM---NAHSLS 2378
            ++ +ET  E L SD E    K +RE+  + + +V +  ++   ++  + S       S+ 
Sbjct: 1857 LQRVETS-EGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIE 1915

Query: 2379 EEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE 2438
             EA  L+  L+VV  EKL LE+  E   + +  ++  L     + NQL  EL ++ ++  
Sbjct: 1916 HEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTT 1975

Query: 2439 SVEKIQSIPENSVNVAIDHLS-------------KDKPELEVVLTEDALKSLENQTYFKS 2485
            +++++    +        H S             K+K EL   L+ D  + L+++T+   
Sbjct: 1976 ALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTH--- 2032

Query: 2486 FEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQK 2545
                       L+ +L  LE    A  L LT+C  ++++   Q   E E+L K+  +LQ 
Sbjct: 2033 -----------LQEKLQSLEKDSQA--LSLTKC--ELENQIAQLNKEKELLVKESESLQA 2077

Query: 2546 IVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALT 2605
             + E                             S+ E+ N+    +    E G       
Sbjct: 2078 RLSE-----------------------------SDYEKLNVSKALEAALVEKGE----FA 2104

Query: 2606 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2665
            LR+S  + +V ++   +   + ++E  EK  L   +KL            K+RE+E    
Sbjct: 2105 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKL------------KERERENDSL 2152

Query: 2666 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN 2725
               VE L+   ++   N+E      L  L AE+  +KAE+ + K + E++   L V E +
Sbjct: 2153 KDKVENLERELQMSEENQE------LVILDAEN--SKAEVETLKTQIEEMARSLKVFELD 2204

Query: 2726 MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGT 2785
            + +L+ +   +   + E + +LS L+K     +  S K+ + E    ++     S+T   
Sbjct: 2205 LVTLRSEKENLTKQIQEKQGQLSELDK-----LLSSFKSLLEEKEQAEIQIKEESKTAVE 2259

Query: 2786 LKISSSNQTPQILVKNAGIQ-INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMES 2844
            +  +   +  + +    G Q I   +E S +   E   Q    IEK++    A+    E 
Sbjct: 2260 MLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD----EK 2315

Query: 2845 RHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSD 2904
            + +   + LK   + A  LLK     L+  ++  R+ +  +  E                
Sbjct: 2316 KQLCVLQQLKESEHHA-DLLKGRVENLERELEIARTNQEHAALE---------------- 2358

Query: 2905 SGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESP 2964
                                     E S+   ++   KI+G+ +++    + V+++    
Sbjct: 2359 ------------------------AENSKGEVETLKAKIEGMTQSLRGLELDVVTIR--- 2391

Query: 2965 YSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRG 3024
             S+ E+ + +   E   +ER + +  I+S  + I + + Q + ++ + S +         
Sbjct: 2392 -SEKENLTNELQKE---QERISELEIINSSFENILQEKEQEKVQMKEKSST--------- 2438

Query: 3025 ELLLALQQVFLEERSVLLAAFRTELTALGTTDA--VGLLNCLEQRIQE--QGVEYQAAME 3080
               + + Q  L+E +  +AA   +  A    +      + CLE    +  QG++      
Sbjct: 2439 --AMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNY 2496

Query: 3081 CLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVEL 3140
             + ++    L+ E++      +G++   K+++E  +   ++ +   +Q  S++ +++ E 
Sbjct: 2497 IVLQSSVNGLIQEVE------DGKQKLEKKDEEISRLKNQIQDQ--EQLVSKLSQVEGEH 2548

Query: 3141 SSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLK-ELEAFRLEVKDK 3199
               K++  EL+      +  +  L+S+ A  +  LE  L++ +K+L+ ELE  ++   DK
Sbjct: 2549 QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEV-LQSSYKNLENELELTKM---DK 2604

Query: 3200 TDEVHLLNDTLASEQK----------KSRELQWALEKEKAKLGRSEERDKEELEDLKFSL 3249
               V  +N   A E +          K+ ELQ  L  EK +L    +   EE++  K  L
Sbjct: 2605 MSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQL 2664

Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
            +     N +L   L+   +   E + K+  +   Y  +L E + ++   Q LL       
Sbjct: 2665 KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKH---QALL------- 2714

Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSE-----DLLKELQKQLEEKHSRIVELLN 3364
                  LD  ++   ++Q+      S+    S      DLLK  +++L        ++L 
Sbjct: 2715 ------LDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE 2768

Query: 3365 ETEKYKLDSL---------------------QTRQQMEKDRQVHRKTL------QTEQEA 3397
            E +K K+D+L                     ++ +Q+E+++++ +K L      Q +Q+ 
Sbjct: 2769 ELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKT 2828

Query: 3398 NTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
             T    K+ EL +++++L+  LEEK ++
Sbjct: 2829 GTVMDTKVDELTTEIKELKETLEEKTKE 2856



 Score =  205 bits (522), Expect = 6e-52
 Identities = 458/2333 (19%), Positives = 959/2333 (41%), Gaps = 416/2333 (17%)

Query: 145  YSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD 204
            +S +  +   + L+    EL   + EIEE   + E+M  ++  E  Q++ + +       
Sbjct: 837  FSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQ 896

Query: 205  GIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLL 264
             ++ +  + L+   +E  + + + +E TEQ++                            
Sbjct: 897  NVVAETLSALENKEKEL-QLLNDKVE-TEQAE---------------------------- 926

Query: 265  QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324
                      Q+L++ +HLLED  K       ++  L E + + E ++   + + NK EI
Sbjct: 927  ---------IQELKKSNHLLEDSLK-------ELQLLSETLSL-EKKEMSSIISLNKREI 969

Query: 325  QE---KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381
            +E   +   ++E+N  + +E+   + L  K  +    + E ++ I + + + K  KL L 
Sbjct: 970  EELTQENGTLKEINASLNQEK---MNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026

Query: 382  NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
               ++   + E++ Q            +K +Q +   ++ +  E     E  + EL+++ 
Sbjct: 1027 QRCEETGNAYEDLSQ-----------KYKAAQEKNSKLECLLNECTSLCENRKNELEQL- 1074

Query: 442  GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY-SNITVNEDQIKLMNVAINELNI 500
             +   +  QE + + +A  EE       E+E   ++  S +T N++  K        L  
Sbjct: 1075 KEAFAKEHQEFLTK-LAFAEERNQNLMLELETVQQALRSEMTDNQNNSK---SEAGGLKQ 1130

Query: 501  KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
            ++     ++ K+++E+  +L+E   L + ++   E  +   E I   R ++ E+ES+ N+
Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPI---RNSVKERESERNQ 1187

Query: 561  AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620
               +     DL+ + +S      +L ++ EA + N ++KL+  EKEK   L    ++   
Sbjct: 1188 C--NFKPQMDLEVKEISLDSYNAQL-VQLEAMLRNKELKLQESEKEKEC-LQHELQTIRG 1243

Query: 621  ELERLRTQLLFSHEEELSKLKEDLEIE---------HRINIEKLKDNLGIHYKQQID-GL 670
            +LE    Q + S  +E+S LK D EI+         H ++  +  DN  +    Q     
Sbjct: 1244 DLETSNLQDMQS--QEISGLK-DCEIDAEEKYISGPHELSTSQ-NDNAHLQCSLQTTMNK 1299

Query: 671  QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
             NE+ +  E +Q EK  L+T+ N             +S   + + +M  ++ +L  E++I
Sbjct: 1300 LNELEKICEILQAEKYELVTELND-----------SRSECITATRKMAEEVGKLLNEVKI 1348

Query: 731  LRQEE-------------KEKGTLEQEVQELQL----------KTELLEKQMKEKENDLQ 767
            L  +               E G    E   + L             L +K+++    +LQ
Sbjct: 1349 LNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQ 1408

Query: 768  EKFAQLEAENSILKDEKKTLED-MLKIHTPVS--QEERLIFLDSIKSKSKDSVWEKEIEI 824
            EKF  L++E+ IL D+   +   M ++ T V   + E L+   ++++   D V  KE+++
Sbjct: 1409 EKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLV--KEMQL 1466

Query: 825  LIEEN--EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882
             +EE     L   C+  +  +       S  + +F   Y+ L E+    + +  +LE + 
Sbjct: 1467 GLEEGLVPSLSSSCVPDSSSLS------SLGDSSF---YRALLEQTGD-MSLLSNLEGAV 1516

Query: 883  NKQELEYKSKLKALNEELHLQRINPTTVKMKS--------SVFDEDKTFVAETLEMGEVV 934
            +  +        +  +E +L R    +   K          V+ +    + E +E   ++
Sbjct: 1517 SANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIM 1576

Query: 935  EKDTTELMEKLEVTKREKLE-LSQRLSDLSEQLKQKHGEISF-LNEEVKSLKQEKEQVSL 992
            +    + +E+L  ++R++L+ L ++    +EQ +QK   ++  +  ++ + K++ EQ+SL
Sbjct: 1577 KNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSL 1636

Query: 993  RCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052
               ELE+         +Q  D    SLL G+ T  +         ++K    E+    E 
Sbjct: 1637 ---ELEV-----ARLQLQGLDLSSRSLL-GIDTEDAIQGRNESCDISKEHTSET---TER 1684

Query: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT-------------QPSENDKLQKEL 1099
                +   + ++  Q+ L LD +  +T+  +++ T             +P   DK Q   
Sbjct: 1685 TPKHDVHQICDKDAQQDLNLD-IEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSS 1743

Query: 1100 NVLKS----------EQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEE 1149
              +              + L  Q +   + L +  +++ +    ++  ++D+ + SL  E
Sbjct: 1744 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNE 1803

Query: 1150 LIFAQEEKIKEL-QKIHQLELQTMKTQETGDEGKPLHLLIGKLQKA---VSEECSYFLQT 1205
            +        KEL  K+H  E+Q M   E   E   L  ++G+L+K    +SE+  YF   
Sbjct: 1804 M--------KELDSKLHLQEVQLMTKIEACIE---LEKIVGELKKENSDLSEKLEYFSCD 1852

Query: 1206 LCSVL-----GEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260
               +L      E     L+   +   +E+ GD +++  D     ++    D +  +  + 
Sbjct: 1853 HQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND----SWKERFLDVENELSRIR 1908

Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKE----ETEFLSIHSQMTNLED 1316
            ++     ++ L L+  L  +   QT+ + LE   EN  K     E E   + S+   L  
Sbjct: 1909 SEKASIEHEALYLEADLEVV---QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRG 1965

Query: 1317 IDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVS 1376
             +++  SK ++  D    K++E+ QELES  S     ++  E   + +   LQ     VS
Sbjct: 1966 -ELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS 2024

Query: 1377 ESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNI-VKLLEKQ 1435
            E     +   + +   E D+Q  +    C  +N    +    E  VKE  ++  +L E  
Sbjct: 2025 ELLKDKTHLQEKLQSLEKDSQ-ALSLTKCELENQIAQLNKEKELLVKESESLQARLSESD 2083

Query: 1436 YQEQLEEEVAKVIVSMSIAFA-----QQTELSRISGGKENTASSKQAHAVCQQEQHYFNE 1490
            Y++    +  +  +     FA      Q E+ ++  G E      +A    +++ H   +
Sbjct: 2084 YEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE--KKQLHIAEK 2141

Query: 1491 MKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE 1550
            +K  +        E   +K K E      ++ E  +E+++   D  +     + + T  E
Sbjct: 2142 LKERER-------ENDSLKDKVENLERELQMSEENQELVI--LDAENSKAEVETLKTQIE 2192

Query: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE-EQLEDMRQELVRQYQEHQQATELLR 1609
            EM    K F        E+ + ++ + ++ +  + ++ +    EL +     +   E   
Sbjct: 2193 EMARSLKVF--------ELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244

Query: 1610 QAHMRQMERQREDQEQLQEEIKRLNRQLA--------QRSSIDNENLVSERERVLLEELE 1661
            QA ++  E  +   E LQ ++K LN  +A         +++  + +   E E  L   +E
Sbjct: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304

Query: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNER 1721
             L+    A  +K  C L+       + +  +G VE    +E E+ R          +N+ 
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE-RELEIAR----------TNQE 2353

Query: 1722 YALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKS 1781
            +A  +A N   ++            ET+   + G + +S +      +  RSE E     
Sbjct: 2354 HAALEAENSKGEV------------ETLKAKIEG-MTQSLRGLELDVVTIRSEKE----- 2395

Query: 1782 CVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQ-RLVRSGFAGTEIDPENE 1840
                                       N+ +++ +E   +S+  ++ S F     + E E
Sbjct: 2396 ---------------------------NLTNELQKEQERISELEIINSSFENILQEKEQE 2428

Query: 1841 ELMLNISS-----RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKC 1895
            ++ +   S      LQ  +++L E ++   +  E  K            ++Q  +  ++C
Sbjct: 2429 KVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA-----------KEQNLSSQVEC 2477

Query: 1896 QE-ELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLC 1954
             E E  + L     A+    V  S   G+I    D K    +++++K + I RL+ ++  
Sbjct: 2478 LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK----QKLEKKDEEISRLKNQI-- 2531

Query: 1955 ASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQ--QLLQETEKLMKEKLEVQCQA 2012
                 ++L ++  Q++ E +L   Q   ++     +EQ  Q+LQ     +++ LEV   +
Sbjct: 2532 --QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSS 2589

Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQ 2072
             K  ++  +  K  ++   E+V++    E E   E+ ++ Q+   L+++L          
Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEEL---------- 2639

Query: 2073 AIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132
                  E++    E+Q L +++K        S+ Q +E+    + LK+  D      + K
Sbjct: 2640 ----SGEKNRLAGELQLLLEEIK-------SSKDQLKELTLENSELKKSLD-----CMHK 2683

Query: 2133 EQLQRDIQERNEEIEKLEFRVRELE---QALLVSADTFQKVEDRKHFGAVEAKPELSLEV 2189
            +Q++++ + R EEI + + R+ E E   QALL+  +                      EV
Sbjct: 2684 DQVEKEGKVR-EEIAEYQLRLHEAEKKHQALLLDTNK-------------------QYEV 2723

Query: 2190 QLQAERDAIDRKEKEITNLE---EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2246
            ++Q  R+ +  KE+ +++ +   + L+  +EEL N  +   Q+  +L+  K ++   + +
Sbjct: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQ 2783

Query: 2247 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI--IQEK-------EVEIDQL 2297
            L++EN+  +  M+ L  + K+ +    +++ +L  + +Q+   QEK       + ++D+L
Sbjct: 2784 LKKENERAQGKMKLLIKSCKQLE----EEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL 2839

Query: 2298 NEQVTKLQQQLKITTDNK-----------VIEEKNELIRD-LETQIECLMSDQ 2338
              ++ +L++ L+  T              +  EK E  ++ LETQ+  L S Q
Sbjct: 2840 TTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQ 2892



 Score =  192 bits (489), Expect = 4e-48
 Identities = 530/2887 (18%), Positives = 1157/2887 (40%), Gaps = 458/2887 (15%)

Query: 972  EISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR--AENVQSCDTQVSSLLDGVVTMTSR 1029
            +I  L  ++  LK+EK+Q   +   LE  +   +   EN ++  T +      ++ +   
Sbjct: 19   KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE- 77

Query: 1030 GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089
                S+ K  +    E ++  E +V+F+   +    KQ + +   L     E   R+ Q 
Sbjct: 78   ----SLEKTKQKISHELQVK-ESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE-RSQQA 131

Query: 1090 SENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD-----KALC 1144
            +++  +   LN   + Q      +   +      Y    ++  + +E  K      KAL 
Sbjct: 132  AQSADVS--LNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189

Query: 1145 SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE--CSYF 1202
            + K      Q          HQ        Q+   E  P HL     +  +  +   SYF
Sbjct: 190  AKKASQTLPQATMNHRDIARHQASSSVFSWQQ---EKTPSHLSSNSQRTPIRRDFSASYF 246

Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPEL--------QDYRYEVQDFQE 1254
                    GE      +  +    ++ +  +   +  P L        Q+ R ++ + + 
Sbjct: 247  S-------GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299

Query: 1255 NMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMK-LEFGEENLPKEETEFLSIHSQMTN 1313
             +     ++  + NK   LQ +L K   +  +  K L    + L +   ++    ++ T 
Sbjct: 300  RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA 359

Query: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQ 1373
            LE        KL  L +     L  Q Q  ES   SL+Q++KE E+ ++ E+   Q+  Q
Sbjct: 360  LEQ-------KLKKLTE----DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ 408

Query: 1374 AVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLE 1433
             + +  +          +T+   Q          KN+   ++      + + T++ + LE
Sbjct: 409  TLDQECIQMKAR-----LTQELQQA---------KNMHNVLQAE----LDKLTSVKQQLE 450

Query: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG--KENTA----SSKQAHAVCQQEQHY 1487
               +E  ++++ +   +   +  ++ EL R      KEN      S ++A  VC  E   
Sbjct: 451  NNLEE-FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL 509

Query: 1488 FN-EMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSD--PHDIPESKDC 1544
             N +  L+Q Q   +  +  +   +   + L +++ +    + L        D+ + +DC
Sbjct: 510  KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569

Query: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQA 1604
                S+++  K +  I  + ++D++S +  ++   L   E     ++++   + +E +  
Sbjct: 570  ----SQDLLKKREHHI--EQLNDKLSKTEKESKALLSALE-----LKKKEYEELKEEKTL 618

Query: 1605 TELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALK 1664
                +  + + + +   ++E LQ +I  L   L  +    +E      ERV   E++   
Sbjct: 619  FSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEY----NERVRTLEMD--- 671

Query: 1665 QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYAL 1724
                  RE L  E+RN      + +    EVE Q     EL +K E           ++ 
Sbjct: 672  ------RENLSVEIRNLHNVLDSKSV---EVETQKLAYMELQQKAE-----------FSD 711

Query: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784
            QK    +  + L+  + T  VE+    H L +L      +        +E E+       
Sbjct: 712  QKHQKEIENMCLKTSQLTGQVEDL--EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769

Query: 1785 EEHTRVTDESIPS--YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEID--PENE 1840
            ++ + VT+E       +    P    +  + + E+G+  S+R         E D  P+N 
Sbjct: 770  KDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSER----SECRLEADQSPKNS 825

Query: 1841 ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELR 1900
             ++ N    L+ ++E   +  S+   Q E     + E+  E+  + ++  +S   +   R
Sbjct: 826  AILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEI-EENLMKAEQMHQSFVAETSQR 884

Query: 1901 -ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRL 1959
              +L E++ A + +  E   A   ++    E  L   +++ +   I  L++      + L
Sbjct: 885  ISKLQEDTSAHQNVVAETLSA---LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941

Query: 1960 QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ---LLQETEKLMKEKLEVQCQAEKVR 2016
            +EL+   + +  E++ +S      K E   + Q+   L +    L +EK+ +  ++E   
Sbjct: 942  KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001

Query: 2017 ---DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073
               D+ +K +  L    +++    ++  +E      DL Q+ +A +++  K+   L+E  
Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061

Query: 2074 I---DREHERDVFQQEIQKLEQQLKVVPRF-QPISEHQTREVEQLANHLK-EKTDKCSEL 2128
                +R++E +  ++   K  Q+      F +  +++   E+E +   L+ E TD  +  
Sbjct: 1062 SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNS 1121

Query: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKH-FGAVEAKPELSL 2187
                  L+++I    EE  K++  V +L Q      +   KV   KH    +E++P  + 
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQ----ENEQLMKVMKTKHECQNLESEPIRNS 1177

Query: 2188 EVQLQAERDAIDRKEKEITNLEE-QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2246
              + ++ER+  + K +    ++E  L+ +  +L           +QLE   +    +LQE
Sbjct: 1178 VKERESERNQCNFKPQMDLEVKEISLDSYNAQL-----------VQLEAMLRNKELKLQE 1226

Query: 2247 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV-----EIDQLNEQV 2301
             E+E +  + +++ +   ++ S+    Q Q +   K  +I  E++      E+       
Sbjct: 1227 SEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN 1286

Query: 2302 TKLQQQLKITTDNKVIE----------EKNELIRDL-ETQIECLMSDQECVKRNRE--EE 2348
              LQ  L+ TT NK+ E          EK EL+ +L +++ EC+ + ++  +   +   E
Sbjct: 1287 AHLQCSLQ-TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNE 1345

Query: 2349 IEQLNEVIEKLQQELAN------IGQKTSMNAHSLS----EEADSLKH------QLDVVI 2392
            ++ LN+    L  EL         G++ +   H +S    +E++S +H      ++ +  
Sbjct: 1346 VKILNDDSGLLHGELVEDIPGGEFGEQPN-EQHPVSLAPLDESNSYEHLTLSDKEVQMHF 1404

Query: 2393 AEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER----ESVEKIQSIPE 2448
            AE   L+++  +   E   + +   + + KM++L   + SLK E      ++   Q    
Sbjct: 1405 AE---LQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLV 1461

Query: 2449 NSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF-EENGKGSIINLETRLLQLEST 2507
              + + ++           V    +L SL + +++++  E+ G  S+++       LE  
Sbjct: 1462 KEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS------NLEGA 1515

Query: 2508 VSAKDLELTQCYKQIKDMQEQGQFETEMLQKK-IVNLQKIVE--EKVAAALVSQIQLEAV 2564
            VSA    + + +      +   + ET     K +  L+ + E   +    L  +++ + +
Sbjct: 1516 VSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGI 1575

Query: 2565 QEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLIL 2624
             +  +  +  Q +SSE +  +      L E+E             +L S  +EM + L  
Sbjct: 1576 MKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ---------KLTSVTLEMESKLAA 1626

Query: 2625 EKEQVEIAEKNVLEKEKKLLELQKL---------------LEGNE------KKQREKEKK 2663
            EK+Q E      LE E   L+LQ L               ++G        K+   +  +
Sbjct: 1627 EKKQTEQLS---LELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTE 1683

Query: 2664 RSPQ-----------------DVEVLKTTTELFHSNEESG-------------------- 2686
            R+P+                 D+E +  T  +  + E SG                    
Sbjct: 1684 RTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSS 1743

Query: 2687 -FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQ---------KDLSQV 2736
               +EL +    +     +    +E    LQ  L VKET+  +L+         + +  +
Sbjct: 1744 ECISEL-SFSGPNALVPMDFLGNQEDIHNLQ--LRVKETSNENLRLLHVIEDRDRKVESL 1800

Query: 2737 RDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQ 2796
             + + E   KL + E +  T+++    AC      I+L K +     G LK  +S+ + +
Sbjct: 1801 LNEMKELDSKLHLQEVQLMTKIE----AC------IELEKIV-----GELKKENSDLSEK 1845

Query: 2797 ILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR-----HISETE 2851
            +   +          C  +E+ + + + +E +    E+HA    D  SR     ++++  
Sbjct: 1846 LEYFS----------CDHQELLQRV-ETSEGLNSDLEMHA----DKSSREDIGDNVAKVN 1890

Query: 2852 TLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ 2911
               +E ++ V+       + KA I      E  ++   A  +  QT ++C      +  +
Sbjct: 1891 DSWKERFLDVENELSRIRSEKASI------EHEALYLEADLEVVQTEKLCLEKDNENKQK 1944

Query: 2912 GIYLTHSQGFDIASEG---RGE-----ESESATDSFPKKIKGLLRAVHNEGMQVLSLTES 2963
             I     +   + SE    RGE     +  +A D   +K+K   + + +   + L     
Sbjct: 1945 VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECL----- 1999

Query: 2964 PYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWR 3023
                   H IQ V+E  ++E+   + T+SS    + K +   + ++    +  ++ S  +
Sbjct: 2000 -------HCIQ-VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTK 2051

Query: 3024 GELLLALQQVFLEERSVLLAAFRTELTALGTTD--AVGLLNCLEQRIQEQGVEYQAAMEC 3081
             EL   + Q+  +E+ +L+    +    L  +D   + +   LE  + E+G E+   +  
Sbjct: 2052 CELENQIAQLN-KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKG-EFALRLSS 2109

Query: 3082 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141
             Q+        E+  L   +   ++ ++ +++ +    E L+           E + E  
Sbjct: 2110 TQE--------EVHQLRRGIEKLRVRIEADEKKQLHIAEKLK-----------EREREND 2150

Query: 3142 SMKDRATELQE--QLSSEKMVVAELKSELAQTKLELETTLKAQHKHL-KELEAFRLEVKD 3198
            S+KD+   L+   Q+S E   +  L +E ++ ++E   TLK Q + + + L+ F L++  
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVE---TLKTQIEEMARSLKVFELDLVT 2207

Query: 3199 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258
               E   L   +  +Q +  EL   L   K+ L   E+ + +  E+ K ++E  + +  +
Sbjct: 2208 LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKE 2267

Query: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3318
            LN    +    L   Q+ +++     D  + EE       Q+    EK+R R      D 
Sbjct: 2268 LN----EAVAALCGDQEIMKATEQSLDPPIEEEH------QLRNSIEKLRAR---LEADE 2314

Query: 3319 ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY-KLDSLQTR 3377
            +++L    Q  +    +       DLLK   + LE    R +E+    +++  L++  ++
Sbjct: 2315 KKQLCVLQQLKESEHHA-------DLLKGRVENLE----RELEIARTNQEHAALEAENSK 2363

Query: 3378 QQMEKDRQVHRKTLQTEQEANTEGQKKMH----ELQSKVEDLQRQLEEKRQQVYKLDLEG 3433
             ++E        TL+ + E  T+  + +      ++S+ E+L  +L+++++++ +L++  
Sbjct: 2364 GEVE--------TLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIIN 2415

Query: 3434 QRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKES 3493
               + I+QE ++++++ +EK  +   + Q                               
Sbjct: 2416 SSFENILQEKEQEKVQMKEKSSTAMEMLQ------------------------------- 2444

Query: 3494 NYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQEN 3553
               +L E+N      +++ E  + K Q ++S+++ L  + ++ LQ       ++I +Q +
Sbjct: 2445 --TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502

Query: 3554 IDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMV 3613
            ++ +I +++    +  ++   +S   +     E+L+ + +++ G      E+  +LRN+ 
Sbjct: 2503 VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLT 2562

Query: 3614 MKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEV 3673
            ++LE++I+  +   A   ++     +   N+E    +E E+   +K++  + + +  A+ 
Sbjct: 2563 VELEQKIQVLQSKNASLQDTLEVLQSSYKNLE----NELELTKMDKMSFVEKVNKMTAKE 2618

Query: 3674 YKLKAEL 3680
             +L+ E+
Sbjct: 2619 TELQREM 2625



 Score =  188 bits (477), Expect = 1e-46
 Identities = 587/3030 (19%), Positives = 1199/3030 (39%), Gaps = 452/3030 (14%)

Query: 668  DGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDL----QQSLVNSKSEEMTLQINE 723
            +GL     QKI+ ++ + D L  ++ Q   ++  L+      +Q + N K+E   L+  E
Sbjct: 10   EGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK-RE 68

Query: 724  LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
             Q+ +EI    EK K  +  E+Q  + +    E Q+   +  +++   +L+   S L+  
Sbjct: 69   NQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERS 128

Query: 784  KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 843
            ++  +       P +  +++       S+               + EDLK++    N+E+
Sbjct: 129  QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSG----------SKYEDLKEK---YNKEV 175

Query: 844  EKQRNTFSFAEKNFEVNYQELQEEYA------CLLKVKDDLEDSKNKQELEYKSKLKALN 897
            E++        K  E   + LQ + A        +  +D      +     ++ +    +
Sbjct: 176  EER--------KRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSH 227

Query: 898  EELHLQRINPTTVKMKSSVF--DEDKTFVAETLEMGEVVEK----DTTELMEKLEVTKRE 951
               + QR  P      +S F  +++ T    TL++G+        D +     L+  K +
Sbjct: 228  LSSNSQR-TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQ 286

Query: 952  KLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQS 1011
              EL  ++++L  +L+    E+     + + L+ + E+  +   E E ++N  R E V++
Sbjct: 287  NQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRT 346

Query: 1012 ------CDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
                    T+ ++L   +  +T    + S  + N    E ++  +E K+  +     EE 
Sbjct: 347  TAQYDQASTKYTALEQKLKKLTE---DLSCQRQN---AESARCSLEQKIKEKEKEFQEEL 400

Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDK-----LQKELNVLKSEQNDLRLQMEA--QRI 1118
             ++Q     L     +   R TQ  +  K     LQ EL+ L S +  L   +E   Q++
Sbjct: 401  SRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL 460

Query: 1119 CLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETG 1178
            C +        Q  +  ENE  +++  +K+E    +    ++ +++  LE +    ++  
Sbjct: 461  CRA----EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516

Query: 1179 DEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL--KCEVNAEDKENSGDYISE 1236
            ++ +       +  KA +      L+ L   + +        K ++   D E   D    
Sbjct: 517  NQSQNF----AEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS-- 570

Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN 1296
                  QD   + +   E ++  L+K TE+ +K L+    L K           E+  E 
Sbjct: 571  ------QDLLKKREHHIEQLNDKLSK-TEKESKALLSALELKK----------KEY--EE 611

Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356
            L +E+T F    S+             KL +  + EK  L+ ++  LE+ + +  QQ+K 
Sbjct: 612  LKEEKTLFSCWKSE-----------NEKLLTQMESEKENLQSKINHLETCLKT--QQIKS 658

Query: 1357 TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEF 1416
             E N       + +   +V    +   L   SV   E + Q+  Y        +    EF
Sbjct: 659  HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV---EVETQKLAY------MELQQKAEF 709

Query: 1417 SGEFGVKEETNIVKLLEKQYQEQLEEEVAKV-IVSMSIAFAQQT--ELSRISGGKENTAS 1473
            S +   KE  N+  L   Q   Q+E+   K+ ++S  I    +   +L        +   
Sbjct: 710  SDQKHQKEIENMC-LKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768

Query: 1474 SKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNS 1533
            SK A  V   E H  + +   Q      +F  +              +GE G       S
Sbjct: 769  SKDASLVTN-EDHQRSLLAFDQQPAMHHSFANI--------------IGEQG-------S 806

Query: 1534 DPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE 1593
             P    E  +C L    E     K   + Q+  D +  S +++ +Q+      L+   +E
Sbjct: 807  MPS---ERSECRL----EADQSPKNSAILQNRVDSLEFS-LESQKQM---NSDLQKQCEE 855

Query: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR-SSIDNE------ 1646
            LV+   E ++      Q H   +    +   +LQE+       +A+  S+++N+      
Sbjct: 856  LVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQL 915

Query: 1647 -NLVSERERVLLEEL--------EALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEE 1697
             N   E E+  ++EL        ++LK+L L   E L  E +  S+          E+ +
Sbjct: 916  LNDKVETEQAEIQELKKSNHLLEDSLKELQLLS-ETLSLEKKEMSSIISLNKREIEELTQ 974

Query: 1698 QTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGIL 1757
            +    KE++          L+ E+  L + +      + E  K+ + + +   +  L +L
Sbjct: 975  ENGTLKEINAS--------LNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026

Query: 1758 DRSSKSQSSASLIWRSEAEASVKS----CVHEEHTRVTDESIPSYSGSDMPRNDINMWSK 1813
             R  ++ ++   + +    A  K+    C+  E T + +            +N++    +
Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENR----------KNELEQLKE 1076

Query: 1814 VTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKV 1873
               +  E  + L +  FA    +  N+ LML + +  QA   ++ +  + + S+    K 
Sbjct: 1077 AFAK--EHQEFLTKLAFA----EERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130

Query: 1874 TQTELMRESFRQKQEATESLKCQEEL----------------------RERLHEESRARE 1911
                L  E  + ++E  + L+  E+L                      +ER  E ++   
Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNF 1190

Query: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ----ELEAEQQ 1967
            +  ++L   E  +D Y  +    E  ++ K   +   E+E  C  + LQ    +LE    
Sbjct: 1191 KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNL 1250

Query: 1968 QIQEERELLSRQKEAMKAE----AGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQV 2023
            Q  + +E+   +   + AE    +GP E    Q       +   +QC  +   + L +  
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQN------DNAHLQCSLQTTMNKLNELE 1304

Query: 2024 KALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAI-DREHERDV 2082
            K  EI   E+     EL   ++  +   R+  + + K L +++   D+  +   E   D+
Sbjct: 1305 KICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDI 1364

Query: 2083 FQQEI--QKLEQQ-LKVVPRFQPIS-EHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD 2138
               E   Q  EQ  + + P  +  S EH T   +++  H  E  +K   L    + L   
Sbjct: 1365 PGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQ 1424

Query: 2139 IQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAI 2198
              + + ++ +L+  V  L+   LV +   +  +     G +  + +L LE  L     + 
Sbjct: 1425 HCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQ-----GDLVKEMQLGLEEGLVPSLSSS 1479

Query: 2199 DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDM 2258
               +    +       +R  LE   +     +++  +   + +         +++F   +
Sbjct: 1480 CVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSV--------DEVFCSSL 1531

Query: 2259 EKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT--TDNKV 2316
            ++  L  KE+ +             A+ ++E E   +   + + KL+++++      NK 
Sbjct: 1532 QEENLTRKETPSAP-----------AKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKE 1580

Query: 2317 IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2376
            I+E  +L+     +++CL   ++ +  N + + ++L  V  +++ +LA   +K      S
Sbjct: 1581 IQELEQLLSSERQELDCLR--KQYLSENEQWQ-QKLTSVTLEMESKLA--AEKKQTEQLS 1635

Query: 2377 LSEEADSLKHQ-LDVVIAEKLAL--EQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
            L  E   L+ Q LD+     L +  E  ++  NE     K    ET  +  +        
Sbjct: 1636 LELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD 1695

Query: 2434 KRERES----VEKI----------QSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLEN 2479
            K  ++     +EKI          +   E S +   +   +DK +       +   S  N
Sbjct: 1696 KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPN 1755

Query: 2480 QTYFKSFEENGKGSIINLETRL-------LQLESTVSAKDLELTQCYKQIKDMQEQGQFE 2532
                  F  N +  I NL+ R+       L+L   +  +D ++     ++K++  +   +
Sbjct: 1756 ALVPMDFLGNQE-DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQ 1814

Query: 2533 TEMLQKKI---VNLQKIVEE--KVAAALVSQIQLEAV--QEYAKFCQDNQTISSEPERTN 2585
               L  KI   + L+KIV E  K  + L  +++  +   QE  +  + ++ ++S+ E   
Sbjct: 1815 EVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLE--- 1871

Query: 2586 IQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2645
              + ++   +++G +++ +     E    V    + +  EK  +E  E   LE + ++++
Sbjct: 1872 -MHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIE-HEALYLEADLEVVQ 1929

Query: 2646 LQKLL--EGNEKKQR--------------EKEKKRSPQDVEVLKTTTELFHSNEESGFFN 2689
             +KL   + NE KQ+              E+ + R   D    KTT     S +      
Sbjct: 1930 TEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQ 1989

Query: 2690 ELEALRAESV-ATKAELASYKEKAEKLQ------EELLVKETNMT----SLQKDLSQVRD 2738
            ELE+ ++E +   +   A  KEK E LQ       ELL  +T++     SL+KD   +  
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSL 2049

Query: 2739 HLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQIL 2798
               E + +++ L KE E  V+ES      E L  +LS+S         K++ S      L
Sbjct: 2050 TKCELENQIAQLNKEKELLVKES------ESLQARLSESDYE------KLNVSKALEAAL 2097

Query: 2799 VKNAGIQINLQSECSSEEVTEI---ISQFTEKIE--KMQELHAAEILDMESRHIS----E 2849
            V+     + L S  + EEV ++   I +   +IE  + ++LH AE L    R       +
Sbjct: 2098 VEKGEFALRLSS--TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155

Query: 2850 TETLKREHYVAVQ---LLKEECGTLKAVIQCLRSKEGSSIPELAHS-DAYQTREICSSDS 2905
             E L+RE  ++ +   L+  +    KA ++ L+++    I E+A S   ++   +     
Sbjct: 2156 VENLERELQMSEENQELVILDAENSKAEVETLKTQ----IEEMARSLKVFELDLVTLRSE 2211

Query: 2906 GSDWGQGIYLTHSQGFDI-----ASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSL 2960
              +  + I     Q  ++     + +   EE E A     ++ K  +  + N   Q+  L
Sbjct: 2212 KENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQN---QLKEL 2268

Query: 2961 TESPYSDGEDHSIQQVSE----PWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSH 3016
             E+  +   D  I + +E    P +EE     N+I  L+    +++   + ++    Q  
Sbjct: 2269 NEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLR---ARLEADEKKQLCVLQQLK 2325

Query: 3017 ESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQE-----Q 3071
            ES  +   +LL    +V   ER + +A    E  AL   ++ G +  L+ +I+      +
Sbjct: 2326 ES--EHHADLLKG--RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLR 2381

Query: 3072 GVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKI------TLKREQESEK--------P 3117
            G+E         ++++ +L +E+Q    +++  +I       + +E+E EK         
Sbjct: 2382 GLELDVVTI---RSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSST 2438

Query: 3118 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET 3177
            + E+L+  +++   ++  +  +  + K +   L  Q+   ++  A+L   L + K     
Sbjct: 2439 AMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIV 2498

Query: 3178 TLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEER 3237
               + +  ++E+E  + +++ K +E+  L + +  +++   +L     + + +L + +  
Sbjct: 2499 LQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV--EGEHQLWKEQNL 2556

Query: 3238 DKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQ-------RMLYDAQLSE 3290
               EL +L   LE + Q     N  L+   ++L  S + +E++       +M +  ++++
Sbjct: 2557 ---ELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613

Query: 3291 EQGRNLELQVLLESEKVRIREMSSTLDRER-----ELHAQLQSSDGTGQSRPPLPSEDLL 3345
               +  ELQ  +     +  E+   L  E+     EL   L+    +      L  E+  
Sbjct: 2614 MTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLEN-- 2671

Query: 3346 KELQKQLEEKHSRIVEL--------------LNETEK-YKLDSLQTRQQMEKDRQVHRKT 3390
             EL+K L+  H   VE               L+E EK ++   L T +Q E + Q +R+ 
Sbjct: 2672 SELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREK 2731

Query: 3391 LQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQ--------------QVYKLDLEGQRL 3436
            L +++E  +  + ++  L+S  E+L   L+   Q               V +L  E +R 
Sbjct: 2732 LTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERA 2791

Query: 3437 QGIMQEFQKQELEREEKRESRRILYQNLNE 3466
            QG M+   K   + EE++E   IL + L++
Sbjct: 2792 QGKMKLLIKSCKQLEEEKE---ILQKELSQ 2818



 Score =  152 bits (384), Expect = 6e-36
 Identities = 281/1418 (19%), Positives = 604/1418 (42%), Gaps = 165/1418 (11%)

Query: 73   VESTVIPESTIMRTLHSGEITSH--EQGFSVELESEI--STTADDCSSEVNGCSFVMRTG 128
            + S+ +P+S+ + +L          EQ   + L S +  + +A+ CS +   CS +    
Sbjct: 1476 LSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEE- 1534

Query: 129  KPTNLLREEE-----FGVDD--SYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
               NL R+E       GV++  S  E   Q      E MES+   K  EI+EL + L   
Sbjct: 1535 ---NLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSE 1591

Query: 182  RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
            R        Q L E E   ++   +  ++ + L   +++ ++   E      Q Q L + 
Sbjct: 1592 RQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLS 1651

Query: 242  FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFL 301
             + L   +T       + + D+ +      T +    +   + +  +  ++D  + I  +
Sbjct: 1652 SRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD--KDAQQDLNLDIEKI 1709

Query: 302  QEKIKV---------------YEMEQDKKVENS----------------------NKEEI 324
             E   V               YE   + K + S                      N+E+I
Sbjct: 1710 TETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDI 1769

Query: 325  QEKETIIEELNTK-------IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 377
               +  ++E + +       I + ++K   L +++   D  L   + Q++ K +    ++
Sbjct: 1770 HNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELE 1829

Query: 378  LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
              +   K++    SE+++      +EL +R        +D+    ++ ++  +    A++
Sbjct: 1830 KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKV 1889

Query: 438  DEMYGQQIVQMKQEL--IRQHMAQMEEMKTRHKGEME-----------NALRSYSNITVN 484
            ++ + ++ + ++ EL  IR   A +E      + ++E           +       I   
Sbjct: 1890 NDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCL 1949

Query: 485  EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC-ALQRQLEDLVEELSFSREQ 543
            E+++ ++    N+L  +L DT S+K    ++L   ++EK   L+    + +  +  +  +
Sbjct: 1950 EEELSVVTSERNQLRGEL-DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAE 2008

Query: 544  IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
            ++   + +    S ++E  K  + +++    +   S++    + + E ++     + E+L
Sbjct: 2009 VKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELL 2068

Query: 604  EKEKNAVLDRMAES--QEAELERLRTQLLFSHEEELSKLKEDLEIEHRI--NIEKLKDNL 659
             KE  ++  R++ES  ++  + +     L    E   +L    E  H++   IEKL+  +
Sbjct: 2069 VKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRI 2128

Query: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTL 719
                K+Q+      +++K++  + E D+L  K   L  E+ ++ +  Q LV   +E    
Sbjct: 2129 EADEKKQL-----HIAEKLKERERENDSLKDKVENLEREL-QMSEENQELVILDAENSKA 2182

Query: 720  QINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSI 779
            ++  L+ +IE + +  K     E ++  L+ + E L KQ++EK+  L E    L +  S+
Sbjct: 2183 EVETLKTQIEEMARSLK---VFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSL 2239

Query: 780  LKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK-QQCIQ 838
            L +EK+  E  +K  +  + E     L  +         ++EI    E++ D   ++  Q
Sbjct: 2240 L-EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQ 2298

Query: 839  LNEEIEKQRNTFSFAEKNFEVNYQELQ--EEYACLLKVKDD-----------------LE 879
            L   IEK R      EK      Q+L+  E +A LLK + +                 LE
Sbjct: 2299 LRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALE 2358

Query: 880  DSKNKQELE-YKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 938
               +K E+E  K+K++ + + L    ++  T++ +      +     E +   E++    
Sbjct: 2359 AENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSF 2418

Query: 939  TELMEKLEVTKREKLELSQRLSD----LSEQLKQKHGEISFLNEEVKSLKQEKEQVS--L 992
              ++++ E   +EK+++ ++ S     L  QLK+ +  ++ L+ + ++ K +++ +S  +
Sbjct: 2419 ENILQEKE---QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQV 2475

Query: 993  RCRELEIIINHNRAENVQSCDTQVSS--LLDGVVTMTSRGAEGSVSKVNKSFGEESKI-- 1048
             C ELE      +A+ +Q  D   ++  +L   V    +  E    K+ K   E S++  
Sbjct: 2476 ECLELE------KAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKN 2529

Query: 1049 MVEDK---VSFENMTVGEES--KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLK 1103
             ++D+   VS  +   GE    K++ L L +L +V  E  ++  Q S+N  LQ  L VL+
Sbjct: 2530 QIQDQEQLVSKLSQVEGEHQLWKEQNLELRNL-TVELEQKIQVLQ-SKNASLQDTLEVLQ 2587

Query: 1104 SEQNDLRLQMEAQRICLSLVYSTHVDQVREY--MENEKDKALCSLKEELIFAQEEKIKEL 1161
            S   +L  ++E  +    +   + V++V +    E E  + +  + ++    QEE   E 
Sbjct: 2588 SSYKNLENELELTK----MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643

Query: 1162 QKI-HQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKC 1220
             ++  +L+L   + + + D+ K L L   +L+K++  +C +  Q              + 
Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL--DCMHKDQVEKEGKVREEIAEYQL 2701

Query: 1221 EVNAEDKENSGDYISENE--DPELQDYRYEVQDFQENMHT------LLNKVTEEYNKLLV 1272
             ++  +K++    +  N+  + E+Q YR ++   +E + +      LL    EE N  L 
Sbjct: 2702 RLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLK 2761

Query: 1273 LQTR-LSKIWGQQTDGMKL--EFGEENLPKEETEFLSIHS--QMTNLEDIDVNHKSKLSS 1327
              T+ L ++   + D +K   +  +EN   +    L I S  Q+   ++I     S+L +
Sbjct: 2762 ATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQA 2821

Query: 1328 LQDLEK------TKLEEQVQELESLISSLQQQLKETEQ 1359
             Q+ +K      TK++E   E++ L  +L+++ KE ++
Sbjct: 2822 AQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADE 2859



 Score =  145 bits (365), Expect = 1e-33
 Identities = 218/1095 (19%), Positives = 473/1095 (43%), Gaps = 170/1095 (15%)

Query: 2    EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
            E+ +  +KLE       +  QR   S+G +   +            D S+  D+  + ++
Sbjct: 1838 ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA---------DKSSREDIGDNVAK 1888

Query: 62   CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
             N+ +      VE+        +  + S + +   +   +E + E+  T   C  + N  
Sbjct: 1889 VNDSWKERFLDVENE-------LSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN-- 1939

Query: 122  SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
                   +   +  EEE  V  S   Q   +  T +    + L     +++E  +ELE  
Sbjct: 1940 ----ENKQKVIVCLEEELSVVTSERNQLRGELDT-MSKKTTALDQLSEKMKEKTQELE-- 1992

Query: 182  RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
              ++ +E L  +Q  EA +K++  ++  L++++ +  ++K     +   L + SQ L + 
Sbjct: 1993 --SHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050

Query: 242  FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE-DYQKKKEDFTMQISF 300
              +L+           +  A L + K+ ++   + L  Q  L E DY+K      ++ + 
Sbjct: 2051 KCELE-----------NQIAQLNKEKELLVKESESL--QARLSESDYEKLNVSKALEAAL 2097

Query: 301  LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
            +++      +       +S +EE+ +    IE+L  +I  +EKK L + +KL   ++   
Sbjct: 2098 VEKGEFALRL-------SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150

Query: 361  ELQEQIVQKNQEI----KNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
             L++++    +E+    +N +L + +++     S  E++ L   +EE+ +       FE 
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAE----NSKAEVETLKTQIEEMAR---SLKVFEL 2203

Query: 417  DIV------QRMEQETQRKLEQLRAELDEMYG----------QQIVQMKQ------ELIR 454
            D+V      + + ++ Q K  QL +ELD++            Q  +Q+K+      E+++
Sbjct: 2204 DLVTLRSEKENLTKQIQEKQGQL-SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQ 2262

Query: 455  QHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKE 514
              + ++ E      G+ E    +  ++    ++   +  +I +L  +L+    ++  + +
Sbjct: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322

Query: 515  ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
            +L         L+ ++E+L  EL  +R            QE    EA  S   VE LKA+
Sbjct: 2323 QLKESEHHADLLKGRVENLERELEIAR----------TNQEHAALEAENSKGEVETLKAK 2372

Query: 575  IVSASESRKELELK----------------------HEAEVTNYKIKLEMLEKEKNAVLD 612
            I   ++S + LEL                        E E+ N   +  + EKE+  V  
Sbjct: 2373 IEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKV-- 2430

Query: 613  RMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQN 672
            +M E     +E L+TQL     E ++ L  D E       +  + NL      Q++ L+ 
Sbjct: 2431 QMKEKSSTAMEMLQTQLK-ELNERVAALHNDQEA-----CKAKEQNL----SSQVECLEL 2480

Query: 673  EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR 732
            E +Q ++ +   K+N I  Q+ +   I +++D +Q L   K EE++   N++Q + +++ 
Sbjct: 2481 EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL-EKKDEEISRLKNQIQDQEQLVS 2539

Query: 733  QEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK 792
            +  + +G   Q  +E  L+   L  ++++K   LQ K A L+    +L+   K LE+ L+
Sbjct: 2540 KLSQVEGE-HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598

Query: 793  IHTPVSQEERLIFLDSI-KSKSKDSVWEKEIEILIEENEDLKQQCI-----------QLN 840
            +    ++ +++ F++ + K  +K++  ++E+  + ++  +L+++              L 
Sbjct: 2599 L----TKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLL 2654

Query: 841  EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
            EEI+  ++      K   +   EL++   C+ K + + E    ++  EY+ +L    E+ 
Sbjct: 2655 EEIKSSKDQL----KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEA-EKK 2709

Query: 901  HLQRINPTTVK-------MKSSVFDEDKTFVAETLEMGEVVE---------KDTTELMEK 944
            H   +  T  +        +  +  +++   ++ LE+  +           K TT+++E+
Sbjct: 2710 HQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEE 2769

Query: 945  LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004
            L+ TK + L+    ++ L ++ ++  G++  L +  K L++EKE +     +L+      
Sbjct: 2770 LKKTKMDNLKY---VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826

Query: 1005 RAENVQSCDTQVSSL 1019
            +   V   DT+V  L
Sbjct: 2827 KTGTVM--DTKVDEL 2839



 Score =  132 bits (333), Expect = 5e-30
 Identities = 334/1714 (19%), Positives = 693/1714 (40%), Gaps = 289/1714 (16%)

Query: 2025 ALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA----------- 2073
            ALE   E   +R ++  QE   +L  L+++ Q  + QL+ +   L +Q            
Sbjct: 4    ALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT 63

Query: 2074 -IDREHER-----DVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC-S 2126
             + RE++R     +  ++  QK+  +L+V        E Q    ++    L+++  +C S
Sbjct: 64   NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123

Query: 2127 ELLLSKEQLQ-------------------------------RDIQER-NEEIE---KLEF 2151
            EL  S++  Q                                D++E+ N+E+E   +LE 
Sbjct: 124  ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183

Query: 2152 RVRELE---------QALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK- 2201
             V+ L+         QA +   D  +       F   + K    L     ++R  I R  
Sbjct: 184  EVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHL--SSNSQRTPIRRDF 241

Query: 2202 -------EKEITNLEEQLEQFREELENK---NEEVQQLHMQLEIQKKESTTRLQEL---- 2247
                   E+E+T     L+  + +  +    N     L  QL+ Q +E   ++ EL    
Sbjct: 242  SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRL 301

Query: 2248 ---EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2304
               E+E K   +  ++L L ++++     + + VL  K    +     + DQ + + T L
Sbjct: 302  QGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL-NKCRDELVRTTAQYDQASTKYTAL 360

Query: 2305 QQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELA 2364
            +Q+LK  T++   + +N         +E  + ++E   +  +EE+ +     + L QE  
Sbjct: 361  EQKLKKLTEDLSCQRQN--AESARCSLEQKIKEKE---KEFQEELSRQQRSFQTLDQECI 415

Query: 2365 NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424
             +  + +          + L+ +LD + + K  LE  +E   +++   +   + +  K N
Sbjct: 416  QMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKEN 475

Query: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484
            +L + +  +K+E            N +    +  +++   LE  L    +K   NQ+  +
Sbjct: 476  ELRRSMEEMKKE-----------NNLLKSHSEQKAREVCHLEAELKN--IKQCLNQS--Q 520

Query: 2485 SFEENGKGSIINLETRLLQLESTVSAKD--LELTQCYKQIKDMQEQGQFETEMLQKKIVN 2542
            +F E  K    + ET L  L+  ++ ++  L L +    + D+++Q     ++L+K+  +
Sbjct: 521  NFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHH 580

Query: 2543 LQKIVE-----EKVAAALVSQIQLEAVQEYAKFCQDNQTIS------------SEPERTN 2585
            ++++ +     EK + AL+S ++L+  +EY +  ++    S             E E+ N
Sbjct: 581  IEQLNDKLSKTEKESKALLSALELKK-KEYEELKEEKTLFSCWKSENEKLLTQMESEKEN 639

Query: 2586 IQN----------LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKN 2635
            +Q+            Q++  E    +  L +    L  ++  +H   +L+ + VE+  + 
Sbjct: 640  LQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN--VLDSKSVEVETQK 697

Query: 2636 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFH-----SNE------- 2683
            +       +ELQ+  E +++K +++ +    +  ++     +L H     SNE       
Sbjct: 698  L-----AYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC 752

Query: 2684 ESGFFNELEALRAESVATKAELASYKEKAEKL-----QEELLVKETNMT----SLQKDLS 2734
                  E E+LR    +  A L + ++    L     Q  +     N+     S+  + S
Sbjct: 753  YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERS 812

Query: 2735 QVRDHLAEAKEKLSILE-KEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
            + R    ++ +  +IL+ + D  E     +  M   L  +  + +  + +    +  + Q
Sbjct: 813  ECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQ 872

Query: 2794 TPQILVKNAGIQIN-LQSECSSEE--VTEIISQFTEKIEKMQ------ELHAAEILDM-E 2843
              Q  V     +I+ LQ + S+ +  V E +S    K +++Q      E   AEI ++ +
Sbjct: 873  MHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKK 932

Query: 2844 SRH-----------ISETETLKREHYVA--------VQLLKEECGTLKAVIQCLRSKEGS 2884
            S H           +SET +L+++   +        ++ L +E GTLK +   L  ++ +
Sbjct: 933  SNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMN 992

Query: 2885 SIPEL-AHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKI 2943
             I +  + ++    RE   S+    + Q   +            R EE+ +A +   +K 
Sbjct: 993  LIQKSESFANYIDEREKSISELSDQYKQEKLILLQ---------RCEETGNAYEDLSQKY 1043

Query: 2944 KGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQL 3003
            K       N  ++ L    +   +   + ++Q+ E + +E + ++  ++  ++    + L
Sbjct: 1044 KAAQE--KNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLML 1101

Query: 3004 QRE-------AEVYDSSQSHESFSDWRGELLLALQQV----------FLEERSVLLAAFR 3046
            + E       +E+ D+  + +S +    + ++ L++            L+E   L+   +
Sbjct: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMK 1161

Query: 3047 TELTALGTTDAVGLLNCLEQRIQEQG-VEYQAAMEC-LQKADRRSLLSEIQALHAQMNGR 3104
            T+       ++  + N +++R  E+    ++  M+  +++    S  +++  L A +  +
Sbjct: 1162 TK-HECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK 1220

Query: 3105 KITLKREQESEKPSQELLEYNIQQ-----KQSQMLEMQ-VELSSMKDRATELQEQLSSEK 3158
            ++ L   QESEK  +E L++ +Q      + S + +MQ  E+S +KD   + +E+  S  
Sbjct: 1221 ELKL---QESEK-EKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGP 1276

Query: 3159 MVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDT----LASEQ 3214
              ++  +++ A  +  L+TT+   ++  K  E  + E   K + V  LND+    + + +
Sbjct: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAE---KYELVTELNDSRSECITATR 1333

Query: 3215 KKSRELQWALEKEKAKLGRSEERDKEELEDL---KFSLESQKQRNLQLN----------- 3260
            K + E+   L + K     S     E +ED+   +F  +  +Q  + L            
Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHL 1393

Query: 3261 LLLEQQKQL----LNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
             L +++ Q+    L E    ++S+  +   Q  +   +  ELQ  ++S K     +S+ L
Sbjct: 1394 TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNL 1453

Query: 3317 -----DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3371
                 D  +E+   L+       S   +P    L  L        S    LL +T    L
Sbjct: 1454 RNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDS-----SFYRALLEQTGDMSL 1508

Query: 3372 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431
             S            V      + QE N   ++        VE+L+   E  RQ + KL+ 
Sbjct: 1509 LSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLE- 1567

Query: 3432 EGQRLQGIMQEFQKQELER---EEKRESRRILYQNLNEPTTW--SLTSDRTRNWVLQQKI 3486
            E    QGIM+  + QELE+    E++E   +  Q L+E   W   LTS       ++ K+
Sbjct: 1568 EKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLE---MESKL 1624

Query: 3487 EGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ 3520
              E K++    L            ELE+ R +LQ
Sbjct: 1625 AAEKKQTEQLSL------------ELEVARLQLQ 1646



 Score = 91.3 bits (225), Expect = 2e-17
 Identities = 130/584 (22%), Positives = 263/584 (45%), Gaps = 71/584 (12%)

Query: 128  GKPTNLLREEEFG-VDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYG 186
            G+  NL RE E    +  ++   A++S   +E +++++ G    +  L  EL+ + +   
Sbjct: 2336 GRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGL--ELDVVTIRSE 2393

Query: 187  TEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQL 245
             E L  +LQ+ +  I + + II     N+ Q + ++   M+E  + +   + LQ Q ++L
Sbjct: 2394 KENLTNELQKEQERISELE-IINSSFENILQEKEQEKVQMKE--KSSTAMEMLQTQLKEL 2450

Query: 246  QASETLRNSTHSSTAADLLQAKQQILTHQQQ-LE-EQDHLLEDYQKKKEDFTM---QISF 300
                    + H+   A   +AK+Q L+ Q + LE E+  LL+   + K ++ +    ++ 
Sbjct: 2451 NERVA---ALHNDQEA--CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNG 2505

Query: 301  LQEKIKVYEMEQDKKVENSN--KEEIQEKETIIEELNT----------KIIEEEKKTLEL 348
            L ++++  + + +KK E  +  K +IQ++E ++ +L+           + +E    T+EL
Sbjct: 2506 LIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVEL 2565

Query: 349  KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 408
            + K+         LQ+ +       KN++ EL  +K  +    E++ ++     ELQ+  
Sbjct: 2566 EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM 2625

Query: 409  HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 468
            H+ +Q   ++ + +  E  R   +L+  L+E+   +     +EL  ++    + +   HK
Sbjct: 2626 HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK--DQLKELTLENSELKKSLDCMHK 2683

Query: 469  GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE----KLKEELGLILEEKC 524
             ++E   +    I   E Q++L + A  +    L DTN Q E      +E+  L  +E+C
Sbjct: 2684 DQVEKEGKVREEIA--EYQLRL-HEAEKKHQALLLDTNKQYEVEIQTYREK--LTSKEEC 2738

Query: 525  ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH-KSLSTVEDLKAEIVSASESRK 583
               ++LE  ++ L  S+E++  + +   +   +L +    +L  V  LK E   A    K
Sbjct: 2739 LSSQKLE--IDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2796

Query: 584  EL-----ELKHEAEVTNYKIKLEMLEKEK---NAVLDRMAESQEAELERLR--------- 626
             L     +L+ E E+   ++      +EK     V+D   +    E++ L+         
Sbjct: 2797 LLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKE 2856

Query: 627  --------TQLLFSHEEELSKLKEDLE--IEHRINIEKLKDNLG 660
                      LL SH E+L K KE LE  + H  + +  +D+ G
Sbjct: 2857 ADEYLDKYCSLLISH-EKLEKAKEMLETQVAHLCSQQSKQDSRG 2899



 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 101/531 (19%), Positives = 208/531 (39%), Gaps = 88/531 (16%)

Query: 3220 LQWALEKEKA------------------KLGRSEERDKEELEDLKFSLESQKQ-----RN 3256
            + WALE+ K                   KL + +++ + +L+ L+ +L+ QKQ     + 
Sbjct: 1    MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60

Query: 3257 LQLNLLLEQQK-----QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3311
               NL  E Q+     + L +++QKI  +  + ++Q++ ++G+    +  +E  +  ++ 
Sbjct: 61   EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120

Query: 3312 MSSTLDRERELHAQLQSSD------GTGQ---SRPPLPSEDLLKELQKQLEEKHSRIVEL 3362
              S L+R ++     QS+D       T Q   + P  PS+       + L+EK+++ VE 
Sbjct: 121  CKSELERSQQ---AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE- 176

Query: 3363 LNETEKYKLDS-LQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEE 3421
                E+ +L++ ++  Q  +  + + + T+     A  +    +   Q +          
Sbjct: 177  ----ERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS 232

Query: 3422 KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP---TTWSLTSDRTR 3478
            +R  + + D       G  +    +   +  KR++    + N + P         +   R
Sbjct: 233  QRTPI-RRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291

Query: 3479 NWV--LQQKIEGETKESN----------------YAKLIEMNGGGTGCNHELEMIRQKLQ 3520
            N +  L+ +++G  KE                    +LIE       C  EL     +  
Sbjct: 292  NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351

Query: 3521 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL-QKLTGQQGE-EPSLVSPS 3578
              ++K   L QK  +         ED    ++N +     L QK+  ++ E +  L    
Sbjct: 352  QASTKYTALEQKLKKL-------TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404

Query: 3579 TSCGSLTERLLRQNAELTGHISQ-------LTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3631
             S  +L +  ++  A LT  + Q       L  E + L ++  +LE  +  ++Q     +
Sbjct: 405  RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAE 464

Query: 3632 NSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
             + + S       E  +    E   +E   L+   ++   EV  L+AEL+N
Sbjct: 465  QAFQAS----QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKN 511



 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 124/624 (19%), Positives = 262/624 (41%), Gaps = 88/624 (14%)

Query: 3135 EMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL----- 3189
            E++ +L  +K    + Q QL S +  + + K ++   K E  T LK +++ L E+     
Sbjct: 22   ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE-GTNLKRENQRLMEICESLE 80

Query: 3190 ---EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK 3246
               +    E++ K  +V+     L S +K+  +L+  L++ K++L RS++    +  D+ 
Sbjct: 81   KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ--AAQSADVS 138

Query: 3247 FSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEK 3306
             +  +  Q+     L   Q       S  K E  +  Y+ ++ E +    E++  L+++K
Sbjct: 139  LNPCNTPQKIFTTPLTPSQY-----YSGSKYEDLKEKYNKEVEERKRLEAEVKA-LQAKK 192

Query: 3307 VRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNET 3366
                   +T++       Q  SS  + Q                  +EK    +   ++ 
Sbjct: 193  ASQTLPQATMNHRDIARHQASSSVFSWQ------------------QEKTPSHLSSNSQR 234

Query: 3367 EKYKLDSLQTRQQMEKDRQVHRKTLQT-EQEANT---EGQKKMHELQSKVEDLQRQLEEK 3422
               + D   +    E++    R TLQ  +++AN+   +     H L    + L+ Q +E 
Sbjct: 235  TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL----DQLKAQNQEL 290

Query: 3423 RQQVYKLDLEGQ----RLQGIMQEFQKQELEREEKR----ESRRILYQNLNE--PTTWSL 3472
            R ++ +L+L  Q     ++G + +FQ+ +L+ E+ +    E  ++L +  +E   TT   
Sbjct: 291  RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350

Query: 3473 TSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHEL-----------EMIRQKLQC 3521
                T+   L+QK++  T++ +  +    N     C+ E            E+ RQ+   
Sbjct: 351  DQASTKYTALEQKLKKLTEDLSCQR---QNAESARCSLEQKIKEKEKEFQEELSRQQRSF 407

Query: 3522 VASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSC 3581
                 + +  KA    + + A +   + +Q  +D++    Q+L     E    +  +   
Sbjct: 408  QTLDQECIQMKARLTQELQQAKNMHNV-LQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466

Query: 3582 GSLTERLLRQNAELTGHISQLTEEKNDLRN-------MVMKLEEQIRWYRQTGAGRDNSS 3634
               ++  +++N EL   + ++ +E N L++        V  LE +++  +Q      N +
Sbjct: 467  FQASQ--IKEN-ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523

Query: 3635 RFSLNGGANIEAIIASEKEVWNREK--LTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPD 3692
                    + E ++   +E  N+++  LTL+K LK A A++ K +         Q L   
Sbjct: 524  EEMKAKNTSQETMLRDLQEKINQQENSLTLEK-LKLAVADLEKQR------DCSQDLLKK 576

Query: 3693 SEHVTLKRIYGKYLRAESFRKALI 3716
             EH  ++++  K  + E   KAL+
Sbjct: 577  REH-HIEQLNDKLSKTEKESKALL 599


>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
          Length = 2479

 Score =  241 bits (614), Expect = 1e-62
 Identities = 508/2542 (19%), Positives = 1040/2542 (40%), Gaps = 456/2542 (17%)

Query: 128  GKPTNLLREEEFGVDDSYSEQGAQ--DSPTHLEM---MESELAGKQHEIEELNREL--EE 180
            G+ T  LR E   ++    ++  +  D    LE    +  +LA +  E E  N +L  E 
Sbjct: 107  GRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRREN 166

Query: 181  MRVTYGTEGL--------QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELT 232
             R+    E L        +Q+   +  +  R G  +   + L +   E  + + E   LT
Sbjct: 167  KRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLT 226

Query: 233  EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE 292
            E ++K+++Q Q+++  + L  S            + + + HQ      D++++  +K+ +
Sbjct: 227  EANEKIEVQNQEMR--KNLEESVQEMEKMTDEYNRMKAIVHQT-----DNVIDQLKKEND 279

Query: 293  DFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKL 352
             + +Q+  L + +K  + E+D  +  +   +++E + I+   + +IIE ++    L++KL
Sbjct: 280  HYQLQVQELTDLLKS-KNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKL 338

Query: 353  TTA----DKL-LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEE---- 403
              A    DK  +  LQ+ I +++ +IK +  ++    ++  +++  I+ L   ++     
Sbjct: 339  KNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGA 398

Query: 404  --LQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQME 461
              L ++ H   Q   DI++   +E +R  E   A+  E         K + + + + +++
Sbjct: 399  STLSQQTHMKIQSTLDILKEKTKEAERTAELAEADARE---------KDKELVEALKRLK 449

Query: 462  EMKTRHKGEMENALRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELG 517
            + ++   G +E+A+    N    I + + +I+++   IN+L +K+ D   + E L+E +G
Sbjct: 450  DYESGVYG-LEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVG 508

Query: 518  L----------ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST 567
            L              K   Q+Q     + L    E ++  R  + ++  ++ +     S 
Sbjct: 509  LEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSA 568

Query: 568  VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRT 627
               L  E ++ +E+  + +   E ++    +K     + KN  L R    +E +LER RT
Sbjct: 569  TSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRT 628

Query: 628  QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDN 687
             ++   + +L +L E+                     +Q++    E+ Q I+ MQ + D 
Sbjct: 629  -VIAKFQNKLKELVEE--------------------NKQLEEGMKEILQAIKEMQKDPD- 666

Query: 688  LITKQNQLILEISKLKDLQQSLVNSKSE-------EMTLQINELQKEIEILRQE----EK 736
               K  +  L I  L+ L  ++ +  +E        +  Q+++L    E LRQE     K
Sbjct: 667  --VKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRK 724

Query: 737  EKGTLEQEVQELQLKTELLEKQ---MKEKEN--------DLQEKFA-------------- 771
            E     Q++ +  LK + LEK+   +++ E         DL +  A              
Sbjct: 725  EAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYL 784

Query: 772  -----QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI 826
                 +LE +   LK+ + +LED  +    +  ++ L++ + +  K     W+ E + + 
Sbjct: 785  IHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKE---TWKTESKTIK 841

Query: 827  EENEDLKQQCIQLNEEIEKQRNTFSFAEKN-----------------FEVNYQELQEEYA 869
            EE   L+ Q  Q   ++++  N  +  + +                  +VN + L  +Y 
Sbjct: 842  EEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYT 901

Query: 870  CLLKVKDDLEDSKNKQELEYKSKLKALNEELH-LQRINPTTVKMKSSVFDEDKTFVAETL 928
             L++++  L     KQ+ E  S    + E++  LQR            F E   F    L
Sbjct: 902  TLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQR------------FKEMAIFKIAAL 949

Query: 929  EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ---LKQKHGEISFLNEEVKSLKQ 985
            +  +VV+   +  + +LE+  ++  EL+ +  D+ ++   L Q+   +  L  E  SLK+
Sbjct: 950  Q--KVVDNSVS--LSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKE 1005

Query: 986  EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
            + E ++   +ELEI     +   ++    Q + L          G E S+ K  KS    
Sbjct: 1006 QVESIN---KELEI--TKEKLHTIEQAWEQETKL----------GNESSMDKAKKSITNS 1050

Query: 1046 SKIMVEDKVSFENMT-VGEESKQE--QLILDHLPSVTKESSLR----ATQPSENDK---- 1094
              + +  K++   M  + E  + E  Q + +HL +  K+   R     T+ +E  K    
Sbjct: 1051 DIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD 1110

Query: 1095 -------LQKEL--------------NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVRE 1133
                   L+ EL               +L+ E+N++ L++E  ++      +    ++  
Sbjct: 1111 AQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILN 1170

Query: 1134 YMENEKDKALCSLKEELIF--AQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKL 1191
              +  +DK + SL+ +L+   AQ ++   + K+HQ  +    ++ T          +GKL
Sbjct: 1171 AQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA---------LGKL 1221

Query: 1192 QKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQD 1251
            +   S+     LQ +     E Y   L+ E   ++KE +  Y         +  R  +Q 
Sbjct: 1222 ESITSK-----LQKM-----EAYN--LRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQS 1269

Query: 1252 FQENMHTLLNKVTEE-YNKLLV-LQTRLSKIWGQQTDGMKLEFGEENLPKE-ETEFLSIH 1308
             +      L    +E ++K ++ LQ    KI  +  +  +     EN   E E +   + 
Sbjct: 1270 LRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLE 1329

Query: 1309 SQMTNLEDID-----VNHKSKLSSLQDLEKTKLEEQ--------------VQELESLISS 1349
              ++ L+D       +N   K+  L+ L++ KL  +              + E E  ISS
Sbjct: 1330 ELISTLKDTKGAQKVINWHMKIEELR-LQELKLNRELVKDKEEIKYLNNIISEYERTISS 1388

Query: 1350 LQQQLKETEQNYEA------------------------EIHCLQKRLQAVSESTVPPSLP 1385
            L++++ +  + +E                         EI    ++ +  + S   PSLP
Sbjct: 1389 LEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLP 1448

Query: 1386 VDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVA 1445
            + + +     A R       +K+NI   +E        EE    KL EK+   +L E+  
Sbjct: 1449 LPNQL---EIALRK------IKENIRIILETRATCKSLEE----KLKEKESALRLAEQNI 1495

Query: 1446 ----KVIVSMSI---AFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFN-EMKLSQDQ 1497
                KVI  + +   A A++ +L    G KE     K  H +    Q   N + +L+Q +
Sbjct: 1496 LSRDKVINELRLRLPATAEREKLIAELGRKE--MEPKSHHTLKIAHQTIANMQARLNQKE 1553

Query: 1498 IGFQTFETVDVKFKEEFKPLSKELGE-----HGKEILLSNSDPHDIPESKDCVLTISEEM 1552
               + ++ +  K +EE + + K+  E     H +  L ++S  +   ++   ++  S   
Sbjct: 1554 EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTP 1613

Query: 1553 FSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAH 1612
               +K FI    +  E +V+  D S   +L   +L+ + Q+L RQ +  +   +      
Sbjct: 1614 VPTNKHFIRLAEM--EQTVAEQDDSLSSLL--VKLKKVSQDLERQREITELKVKEFENIK 1669

Query: 1613 MRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE--------------RVLLE 1658
            ++  E   ++ ++++ E++ L + L  +S  +++ L SE +              R L+E
Sbjct: 1670 LQLQENHEDEVKKVKAEVEDL-KYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVE 1728

Query: 1659 ELE---ALKQLSLAGREKLCCELRNSSTQTQNGN--ENQGEVEEQTFKEKELDRKPEDVP 1713
             L+   ALK+       +   ELR   T            + E     ++ +DR   ++ 
Sbjct: 1729 RLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELK 1788

Query: 1714 PEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRS 1773
             ++        +  N  LLK L E +KT+   E ++  ++  + +   K Q + + I R 
Sbjct: 1789 TQV--------EDLNENLLK-LKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILRE 1839

Query: 1774 EAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGT 1833
            + E   ++   +E  R          G  +  N  ++  ++  +  +L  +L        
Sbjct: 1840 KEEIDQEN---DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQL-EGKVEEV 1895

Query: 1834 EIDPENEE------LMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ 1887
            ++ P  E+      +      + QA +E +   + E   ++      Q   +++ F +  
Sbjct: 1896 DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEV-FTLTKQLNTLKDLFAKAD 1954

Query: 1888 EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
            +  E L  Q +L+       +     A+E  K         + + L +R +  + DI+  
Sbjct: 1955 K--EKLTLQRKLKTTGMTVDQVLGIRALESEK---------ELEELKKRNLDLENDILYM 2003

Query: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV-----------EQQLLQ 1996
               + L   + +++L  + + +QE+   L +Q          +           EQ+L +
Sbjct: 2004 RAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQK 2063

Query: 1997 ETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQ 2056
            E  KL  E +E++ Q E+   DL + +K    D++E      + + E   +L  +R   +
Sbjct: 2064 ENLKLSSENIELKFQLEQANKDLPR-LKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGR 2122

Query: 2057 A------LEKQLEKMRKFLDEQAIDREHER------DVFQQEIQKLEQQL-KVVPRFQPI 2103
            +      LEK +  M+K +++  + RE+E+       +  +++  +EQ+  K+    + +
Sbjct: 2123 SGKTIPELEKTIGLMKKVVEK--VQRENEQLKKASGILTSEKMANIEQENEKLKAELEKL 2180

Query: 2104 SEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVS 2163
              H      QL+ H + KT    +++   E+L++++++  +  EKL      LE  +L  
Sbjct: 2181 KAHLGH---QLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE--ILNE 2235

Query: 2164 ADTFQKVEDRKHFGAVEAK-PELS---------------LEVQLQAERDAIDRKEKEITN 2207
              T Q  E  K     E++ P+L                 E +L+     I +K + IT+
Sbjct: 2236 KMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITD 2295

Query: 2208 LEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE 2267
            L++ +++  E  +  N+  + L  Q++I K      + E  +  +  K +++ L LA   
Sbjct: 2296 LKQLVKEATEREQKVNKYNEDLEQQIKILK-----HVPEGAETEQGLKRELQVLRLA--- 2347

Query: 2268 SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL 2327
                     H L  + A++I + E   DQ   + T          D   ++EK   I+DL
Sbjct: 2348 --------NHQLDKEKAELIHQIEANKDQSGAEST--------IPDADQLKEK---IKDL 2388

Query: 2328 ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQ 2387
            ETQ++  MSD E          + L E I+KL++EL N          S  EE + LK+ 
Sbjct: 2389 ETQLK--MSDLEK---------QHLKEEIKKLKKELENFDP-------SFFEEIEDLKYN 2430

Query: 2388 LDVVIAEKLALEQQVETANEEM 2409
                + + + LE++V+  +E++
Sbjct: 2431 YKEEVKKNILLEEKVKKLSEQL 2452



 Score =  221 bits (562), Expect = 1e-56
 Identities = 496/2623 (18%), Positives = 1110/2623 (42%), Gaps = 357/2623 (13%)

Query: 290  KKEDFTMQISFLQEKIKVYEMEQDKK---------VENSNKEEIQEKETIIEELNTKIIE 340
            ++E+    +     K++V E++ +K+          ++  K + QE E  +EE+     E
Sbjct: 20   RQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEE 79

Query: 341  EEK-------KTLELKDKLTTADKLLG------------ELQEQIVQKNQEIKNMKLELT 381
            + K       K ++L+++L  A +  G            +L++Q+ QK++E+++M+ EL 
Sbjct: 80   QAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKEL- 138

Query: 382  NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
               +KE++ +E   QL    EE +  N K        ++R  +  ++K EQL  ++ + Y
Sbjct: 139  ---EKEKKVNE---QLALRNEEAENENSK--------LRRENKRLKKKNEQLCQDIID-Y 183

Query: 442  GQQIVQMKQELI--RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499
             +QI   K+ L+  R   +      ++   E+   L     +T   ++I++ N    E+ 
Sbjct: 184  QKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQN---QEMR 240

Query: 500  IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559
              L+++  + EK+ +E   +     A+  Q ++++++L    +  Q   Q + +     N
Sbjct: 241  KNLEESVQEMEKMTDEYNRMK----AIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN 296

Query: 560  EAHKSLSTVEDLKAE---IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616
            E    +    + K E   ++ +S+  + +E +        K+K   L+ +K+ V+     
Sbjct: 297  EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQG 356

Query: 617  SQEAELE-RLRTQLLFSHEEELSK---LKEDL--EIEHRINIEKLKDNLGIHYKQQIDGL 670
             QE + + ++ T+ +  + +E+ K   + EDL  E++       L     +  +  +D L
Sbjct: 357  IQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDIL 416

Query: 671  QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
            + +  +   T +  + +   K  +L+  + +LKD +  +     E+  ++I   + +I+I
Sbjct: 417  KEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGL--EDAVVEIKNCKNQIKI 474

Query: 731  LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD----EKKT 786
              +E                  E+L K++    N L+ K +    EN  L++    E KT
Sbjct: 475  RDRE-----------------IEILTKEI----NKLELKISDFLDENEALRERVGLEPKT 513

Query: 787  LEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQ 846
            + D+ +       +++       + ++++ +  KEIE L EE  DLK++  Q+ +E  K+
Sbjct: 514  MIDLTEFRNSKHLKQQ-------QYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKR 566

Query: 847  RNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL---KALNEELHLQ 903
              T     +  ++N  E   +   + + K DL   KN  E + K++    + + +E  L+
Sbjct: 567  SATSGLTTE--DLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLE 624

Query: 904  RINPTTVKMKSSV---FDEDKTF---VAETLEMGEVVEKD-------TTELMEKLE---- 946
            R      K ++ +    +E+K     + E L+  + ++KD       T+ ++  LE    
Sbjct: 625  RSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVN 684

Query: 947  -VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
             +  +    +      L  Q+ Q  G    L +E++  ++E    S +  +  + I+H  
Sbjct: 685  AIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLE 744

Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
             E      ++ S+++   + +    A  S S +N        ++ E +   + +   E+S
Sbjct: 745  KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDS 804

Query: 1066 KQEQ----LILDHLPSVTKESSL--RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC 1119
             ++      ++ H  S+  +  L  + T  +E+  +++E   L+ +     ++++     
Sbjct: 805  LEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNL 864

Query: 1120 LSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179
            L+ +     +  +   EN +   +  + E+ +  Q   + EL++  + E +  K +    
Sbjct: 865  LNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSM 924

Query: 1180 EGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED 1239
            E +     IG LQ+   E   + +  L  V+    + +     N +  E +  Y    + 
Sbjct: 925  EAEVCEK-IGCLQR-FKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQK 982

Query: 1240 PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR----LSKIWGQQTDGMKLEFGEE 1295
              +   R    +  E  +  L +  E  NK L +       + + W Q+T     + G E
Sbjct: 983  DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQET-----KLGNE 1037

Query: 1296 NLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL-ESLISSLQQQL 1354
            +   +  +       +TN + + ++ K  +  +++L + +  E  Q++ E L +SL+Q  
Sbjct: 1038 SSMDKAKK------SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM- 1090

Query: 1355 KETEQNYE-----AEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKN 1409
               E+N+E     AE+  +    Q V +          S  ++++D QR +      K  
Sbjct: 1091 --EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRIL---ELEKNE 1145

Query: 1410 IDGTIEFSGEFGVKEETNI----VKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465
            ++  +E S    ++E ++I    V++L  Q Q + ++EV  + + +    AQ  E S I+
Sbjct: 1146 MELKVEVSK---LREISDIARRQVEILNAQQQSR-DKEVESLRMQLLDYQAQSDEKSLIA 1201

Query: 1466 GGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF--KPLSKELGE 1523
               ++  S + + A    +           +    +  + +D K +  +  +   +   +
Sbjct: 1202 KLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 1261

Query: 1524 HGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLN 1583
            H ++ + S        +    +    +E FSK  T I  Q+   +I     ++ ++    
Sbjct: 1262 HLRQTIQSLRR-----QFSGALPLAQQEKFSK--TMIQLQNDKLKIMQEMKNSQQEHRNM 1314

Query: 1584 EEQLEDMR------QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL 1637
            E +  +M       +EL+   ++ + A +++   HM+         E+L+ +  +LNR+L
Sbjct: 1315 ENKTLEMELKLKGLEELISTLKDTKGAQKVINW-HMKI--------EELRLQELKLNREL 1365

Query: 1638 AQRSSIDN--ENLVSERERVL--LEELEALKQLSLAGREKLCCELRNSSTQTQNG--NEN 1691
             +         N++SE ER +  LEE E ++Q       ++  + R    + Q    +  
Sbjct: 1366 VKDKEEIKYLNNIISEYERTISSLEE-EIVQQNKFHEERQMAWDQREVDLERQLDIFDRQ 1424

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
            Q E+     K +E      D    + +    AL+K    + +I+LE   T  ++EE +  
Sbjct: 1425 QNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENI-RIILETRATCKSLEEKLKE 1483

Query: 1752 H--VLGILDRSSKSQSSA--SLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807
                L + +++  S+      L  R  A A  +  + E   +  +    S+    +    
Sbjct: 1484 KESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK--SHHTLKIAHQT 1541

Query: 1808 I-NMWSKVT--EEGTELSQRLV-RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863
            I NM +++   EE  +  QRL+ ++     EI  ++EE +  +  RL+   +  L    +
Sbjct: 1542 IANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQ 1601

Query: 1864 TSSQLEHAKVTQTEL---------MRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914
            T+  L     T             M ++  ++ ++  SL  +  L++   +  R RE   
Sbjct: 1602 TAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVK--LKKVSQDLERQREITE 1659

Query: 1915 VELSKAEGVI----DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ---------- 1960
            +++ + E +     + + DE    + ++++   ++D+ ++E  C  + LQ          
Sbjct: 1660 LKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAP 1719

Query: 1961 ---------ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
                      L+++    +++++ LSR    ++AE     ++ +       +  L VQ  
Sbjct: 1720 TTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQI 1779

Query: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
             ++   +L+ QV+ L  ++ +        +  +N+   +L   N  L+K+ +   K L E
Sbjct: 1780 VDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILRE 1839

Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVP---RFQPISEHQTREVEQLANHLKEKTDKCSEL 2128
            +  + + E D  +++I++L   L+  P     Q + E   R+V++L N L+ K ++  +L
Sbjct: 1840 KE-EIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV-DL 1897

Query: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVS-ADTF---QKVEDRKHFGAVEAKPE 2184
               KE+  ++   R EE +K + ++  +   L     + F   +++   K   A   K +
Sbjct: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957

Query: 2185 LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ--LHMQLEIQKKESTT 2242
            L+L+ +L+     +D+    I  LE + E   EEL+ +N +++   L+M+   Q     +
Sbjct: 1958 LTLQRKLKTTGMTVDQV-LGIRALESEKEL--EELKKRNLDLENDILYMRAH-QALPRDS 2013

Query: 2243 RLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2302
             +++L  +N+  ++ +     A+++  +  T  +  + G  +    ++E E+ + N +++
Sbjct: 2014 VVEDLHLQNRYLQEKLH----ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLS 2069

Query: 2303 KLQQQLKITTD--NKVIEEKNELIRDLETQIECLMSDQECVKRNR--------------- 2345
                +LK   +  NK +      +RDL+   E L  ++  V+R                 
Sbjct: 2070 SENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPE 2129

Query: 2346 -EEEIEQLNEVIEKLQQELANI----GQKTSMNAHSLSEEADSLKHQLDVV---IAEKLA 2397
             E+ I  + +V+EK+Q+E   +    G  TS    ++ +E + LK +L+ +   +  +L+
Sbjct: 2130 LEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLS 2189

Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDH 2457
            +  + +T   E    +N          +L +EL   K+E ++ EK++ I +N++ +    
Sbjct: 2190 MHYESKTKGTEKIIAEN---------ERLRKEL---KKETDAAEKLR-IAKNNLEIL--- 2233

Query: 2458 LSKDKPELEVVLTEDALKSLENQ-TYFKSFEENGKGSII---NLETRLLQLESTVSAKDL 2513
               +K  +++  T   L+  E++    +  +     SI+     ET+L +LE+ ++ K+ 
Sbjct: 2234 --NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQ 2291

Query: 2514 ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQD 2573
             +T   + +K+  E+        ++K+    + +E+++         L+ V E A+    
Sbjct: 2292 SITDLKQLVKEATER--------EQKVNKYNEDLEQQIKI-------LKHVPEGAE---- 2332

Query: 2574 NQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQ----V 2629
                                E  L  ++  L L   +L+ +  E+   +   K+Q     
Sbjct: 2333 -------------------TEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAES 2373

Query: 2630 EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFN 2689
             I + + L+++ K LE Q  +   EK+  ++E K+  +++E           N +  FF 
Sbjct: 2374 TIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE-----------NFDPSFFE 2422

Query: 2690 ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKD 2732
            E+E L+        +    +EK +KL E+L V+ T+  +  ++
Sbjct: 2423 EIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEE 2465



 Score =  179 bits (454), Expect = 5e-44
 Identities = 388/1983 (19%), Positives = 836/1983 (42%), Gaps = 254/1983 (12%)

Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATESLKC 1895
            P  EEL  N+   L     ++ E  SE    + H  ++TQ+ +       K +A E    
Sbjct: 19   PRQEELADNLLISLSKV--EVNELKSEKQENVIHLFRITQSLM-------KMKAQEVELA 69

Query: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
             EE+ +   E+++   QL  ++ K E  ++    +++   R  +   + I +LE++L   
Sbjct: 70   LEEVEKAGEEQAKFENQLKTKVMKLENELE--MAQQSAGGRDTRFLRNEICQLEKQLEQK 127

Query: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ---LLQETEKLMKEKLEVQCQA 2012
               L+++E E ++ ++  E L+ + E  + E   + ++   L ++ E+L ++ ++ Q Q 
Sbjct: 128  DRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQI 187

Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRF-IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
            +  ++ L  + +  + D   Q+S+   EL Q  + E+  L + N+ +E Q ++MRK L+E
Sbjct: 188  DSQKETLLSR-RGEDSDYRSQLSKKNYELIQYLD-EIQTLTEANEKIEVQNQEMRKNLEE 245

Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131
               + E   D + +    + Q   V+ + +  ++H   +V++L + LK K ++   ++++
Sbjct: 246  SVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVA 305

Query: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQL 2191
                       N ++E+ +  +   +  ++        + ++     ++A      +  +
Sbjct: 306  V----------NAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDAD-----KSNV 350

Query: 2192 QAERDAIDRKEKEITNLEEQLEQFREELEN--------KNE---------EVQQLHMQLE 2234
             A +  I  ++ +I  L EQ+EQ+ +E+E         KNE           QQ HM+++
Sbjct: 351  MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQ 410

Query: 2235 I------QKKESTTRLQELEQENKLFKDDMEKLGLAIK-----ESDAMSTQDQHVLFGKF 2283
                   +K +   R  EL + +   KD  ++L  A+K     ES     +D  V     
Sbjct: 411  STLDILKEKTKEAERTAELAEADAREKD--KELVEALKRLKDYESGVYGLEDAVVEIKNC 468

Query: 2284 AQIIQEKEVEIDQLNEQVTKLQQQLK-ITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2342
               I+ ++ EI+ L +++ KL+ ++     +N+ + E+  L       +    + +   +
Sbjct: 469  KNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528

Query: 2343 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE-EADSLKHQLDVVIAEKLALEQQ 2401
            +    E + L + IE L++E  ++ +K    A    +  A S     D+ + E ++   +
Sbjct: 529  QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588

Query: 2402 VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2461
            +     ++  +KN + E   K   L++EL   +R+ E    + +  +N +   ++   + 
Sbjct: 589  ISERKLDLLSLKN-MSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQL 647

Query: 2462 KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ 2521
            +  ++ +L   A+K ++     K     G+ S+I     +  LE  V+A           
Sbjct: 648  EEGMKEIL--QAIKEMQKDPDVK----GGETSLI-----IPSLERLVNA----------- 685

Query: 2522 IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2581
            I+    +G F+  +  K  V+      E++   L  + + EA+    +  + N  I    
Sbjct: 686  IESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL-RESRKEAINYSQQLAKANLKIDHLE 744

Query: 2582 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLE-KE 2640
            + T++     LR+ E GS++     +  +L   +     S+I  + +  I     LE KE
Sbjct: 745  KETSL-----LRQSE-GSNV---VFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKE 795

Query: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700
            KKL  L+  LE   +K              V++    L +      + +E E  + ES  
Sbjct: 796  KKLKNLEDSLEDYNRK------------FAVIRHQQSLLYKE----YLSEKETWKTESKT 839

Query: 2701 TKAELASYKEKAEKLQEELLVKETN--MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEV 2758
             K E    +++ +  Q+ + VKE N  + +LQ D  +++  LAE   K+++L+  +++ +
Sbjct: 840  IKEEKRKLEDQVQ--QDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897

Query: 2759 QESKKACMFEPLPIKLSKS-----IASQTDGTLKISSSNQTPQILV-KNAGIQINLQSEC 2812
            ++       E    K ++      ++ + +   KI    +  ++ + K A +Q  + +  
Sbjct: 898  RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957

Query: 2813 SSEEVTEIISQFTEKIEKMQEL---------HAAEILDMESRHIS----------ETETL 2853
            S  E+     Q+ E   K +++           + +  +E  +IS          E E  
Sbjct: 958  SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEIT 1017

Query: 2854 KREHYVAVQLLKEE--CGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ 2911
            K + +   Q  ++E   G   ++ +  +S   S I  ++        +  +    ++  Q
Sbjct: 1018 KEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQ 1077

Query: 2912 GIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDH 2971
             +Y  H +      E R  E E+    F +  K  L A   E M    L +S      D 
Sbjct: 1078 KMY-EHLRTSLKQMEERNFELET---KFAELTKINLDAQKVEQMLRDELADSVSKAVSDA 1133

Query: 2972 SIQQVSEPWLE----ERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL 3027
              Q++ E  LE    E K  ++ +  + D+      +R+ E+ ++ Q           + 
Sbjct: 1134 DRQRILE--LEKNEMELKVEVSKLREISDI-----ARRQVEILNAQQQSRDKEVESLRMQ 1186

Query: 3028 LALQQVFLEERSVLLAAFR-------TELTALGTTDAV--------GLLNCLEQRIQE-Q 3071
            L   Q   +E+S++    +       +E TALG  +++             LEQ++ E +
Sbjct: 1187 LLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKE 1246

Query: 3072 GVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS 3131
               Y A +E   +A  + L   IQ+L  Q +G  + L ++++  K   +L    ++  Q 
Sbjct: 1247 QALYYARLEGRNRA--KHLRQTIQSLRRQFSG-ALPLAQQEKFSKTMIQLQNDKLKIMQ- 1302

Query: 3132 QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEA 3191
            +M   Q E  +M+++  E++ +L   + +++ LK      K+ +   +K +   L+EL+ 
Sbjct: 1303 EMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKV-INWHMKIEELRLQELKL 1361

Query: 3192 FRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLES 3251
             R  VKDK +E+  LN+ ++  ++       +LE+E  +  +  E  +   +  +  LE 
Sbjct: 1362 NRELVKDK-EEIKYLNNIISEYERTIS----SLEEEIVQQNKFHEERQMAWDQREVDLER 1416

Query: 3252 QKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3311
                  QL++   QQ ++LN +Q+  E+   + D  L       + L+ + E+ ++ +  
Sbjct: 1417 ------QLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILET 1470

Query: 3312 MSSTLDRERELHAQ-----------LQSSDGTGQSRPPLPS----EDLLKEL-QKQLEEK 3355
             ++    E +L  +           L       + R  LP+    E L+ EL +K++E K
Sbjct: 1471 RATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK 1530

Query: 3356 HSRIVELLNETEKYKLDSLQTRQQ-MEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3414
                +++ ++T       L  +++ ++K +++  K  + ++E   + ++ +H L  ++E 
Sbjct: 1531 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLE- 1589

Query: 3415 LQRQLEEKRQQVYKLDLEGQRLQGI--------MQEFQKQELEREEKRESRRILYQNLNE 3466
            LQ      + +    DL  Q    +        + E ++   E+++   S  +  + +++
Sbjct: 1590 LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ 1649

Query: 3467 --PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVAS 3524
                   +T  + + +   + I+ + +E++  ++ ++        + L+  +++ QC+ S
Sbjct: 1650 DLERQREITELKVKEF---ENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKS 1706

Query: 3525 KLQVLPQKAS-----------ERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPS 3573
            +LQ   +  S           ERL+ + A  E     Q+ +   +L+L+       EE  
Sbjct: 1707 ELQAQKEANSRAPTTTMRNLVERLKSQLALKEK---QQKALSRALLELRAEMTAAAEERI 1763

Query: 3574 LVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNS 3633
            +     S  S  E  L     +  H  +L  +  DL   ++KL+E ++    T   R+NS
Sbjct: 1764 I-----SATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALK----TSKNRENS 1814

Query: 3634 SRFSLNGGAN-------IEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLL 3686
               +LN   N           I  EKE  ++E   L++ +KR  + +          SL+
Sbjct: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLI 1874

Query: 3687 QTL 3689
            + L
Sbjct: 1875 EEL 1877



 Score =  176 bits (447), Expect = 3e-43
 Identities = 519/2690 (19%), Positives = 1099/2690 (40%), Gaps = 448/2690 (16%)

Query: 932  EVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSL-KQEKEQV 990
            E+++ D  +L  + E+     + LS+   +++E   +K   +  L    +SL K + ++V
Sbjct: 9    EIMKVDPDDLPRQEELADNLLISLSK--VEVNELKSEKQENVIHLFRITQSLMKMKAQEV 66

Query: 991  SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKV--NKSFGEESKI 1048
             L   E+E      +A+      T+V  L +  + M  + A G  ++   N+    E ++
Sbjct: 67   ELALEEVEKA-GEEQAKFENQLKTKVMKL-ENELEMAQQSAGGRDTRFLRNEICQLEKQL 124

Query: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108
              +D+   E+M   +E ++E+ + + L    +E+       +EN KL++E         +
Sbjct: 125  EQKDR-ELEDME--KELEKEKKVNEQLALRNEEAE------NENSKLRRE---------N 166

Query: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL- 1167
             RL+ + +++C  ++        ++ ++++K+  L    E+  +  +   K  + I  L 
Sbjct: 167  KRLKKKNEQLCQDII------DYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLD 220

Query: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
            E+QT+      +  + + +   +++K + E     +Q +  +  EY    +K  V+  D 
Sbjct: 221  EIQTLT-----EANEKIEVQNQEMRKNLEES----VQEMEKMTDEYNR--MKAIVHQTD- 268

Query: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287
             N  D + +  D     Y+ +VQ+  +    LL    EE + ++V               
Sbjct: 269  -NVIDQLKKEND----HYQLQVQELTD----LLKSKNEEDDPIMVAVNA----------- 308

Query: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQ-DLEKTK---LEEQVQEL 1343
             K+E  +  L  ++ E +     + NL +       KL + Q D +K+    L++ +QE 
Sbjct: 309  -KVEEWKLILSSKDDEIIEYQQMLHNLRE-------KLKNAQLDADKSNVMALQQGIQER 360

Query: 1344 ESLISSLQQQLKETEQNYEAE---IHCLQKRLQ------AVSEST-VPPSLPVDSVVITE 1393
            +S I  L +Q+++  +  E     I  L+  LQ       +S+ T +     +D +    
Sbjct: 361  DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420

Query: 1394 SDAQRTMYPGSCVKKNIDGTIEF---------SGEFGVKEETNIVKLLEKQYQ------E 1438
             +A+RT        +  D  +           SG +G+++    +K  + Q +      E
Sbjct: 421  KEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE 480

Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGGKE-----NTASSKQAHAVCQQEQHYFNEMKL 1493
             L +E+ K+ + +S  F  + E  R   G E     +    + +  + QQ+    N++ L
Sbjct: 481  ILTKEINKLELKIS-DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILL 539

Query: 1494 SQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553
             +     ++ E   +  K++ + +++E G+      L+  D + + E+      ISE   
Sbjct: 540  KE----IESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLN-LTENISQGDRISERKL 594

Query: 1554 S--KDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQA 1611
                 K     QS ++ +S   ++  R L  +   +   + +L    +E++Q  E +++ 
Sbjct: 595  DLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEI 654

Query: 1612 HMRQMERQREDQEQLQEE---IKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS- 1667
                 E Q++   +  E    I  L R +   ++I+++N     E +    L    Q+  
Sbjct: 655  LQAIKEMQKDPDVKGGETSLIIPSLERLV---NAIESKNA----EGIFDASLHLKAQVDQ 707

Query: 1668 LAGR-EKLCCELRNSSTQTQNGNENQGEVE---EQTFKEKELDRKPE---------DVPP 1714
            L GR E+L  ELR S  +  N ++   +     +   KE  L R+ E         D+P 
Sbjct: 708  LTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPD 767

Query: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774
             I  +    +   N  L+ +L E+      ++          L+ S +  +    + R +
Sbjct: 768  GIAPSSASIINSQNEYLIHLLQELENKEKKLKN---------LEDSLEDYNRKFAVIRHQ 818

Query: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834
                 K  + E+ T  T+                     + EE  +L  ++ +      E
Sbjct: 819  QSLLYKEYLSEKETWKTESKT------------------IKEEKRKLEDQVQQDAIKVKE 860

Query: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRE---------SFRQ 1885
             +        N+ + LQ   +++ + ++E S ++   +V +  L+R+           R+
Sbjct: 861  YN--------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRK 912

Query: 1886 KQEA--TESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD--EKTLFERQIQEK 1941
            + E    E L  + E+ E++    R +E    +++  + V+D      E  L  +Q  E 
Sbjct: 913  ENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNEL 972

Query: 1942 T----DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE 1997
            T    DI+ + +  L+  ++ L+ LE E   ++E+ E ++++ E  K +   +EQ   QE
Sbjct: 973  TAKYRDILQK-DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQE 1031

Query: 1998 TEKLMKEKLEVQCQAEKVRDDL---QKQVKALE---IDVEEQVSRFIELEQEKNTELMDL 2051
            T KL  E    + +      D+    K++  LE   ++  ++     ++ +   T L  +
Sbjct: 1032 T-KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM 1090

Query: 2052 RQQNQALEKQLEKMRKF-LDEQAID---REHERDVFQQ-----------EIQKLEQQLKV 2096
             ++N  LE +  ++ K  LD Q ++   R+   D   +           E++K E +LKV
Sbjct: 1091 EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKV 1150

Query: 2097 -VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
             V + + IS+   R+VE                +L+ +Q  RD +  +  ++ L+++ + 
Sbjct: 1151 EVSKLREISDIARRQVE----------------ILNAQQQSRDKEVESLRMQLLDYQAQS 1194

Query: 2156 LEQALLVSADTFQ---KVEDRKHFGAVEA------KPE---LSLEVQLQAERDAIDRKEK 2203
             E++L+          ++ +    G +E+      K E   L LE +L  +  A+     
Sbjct: 1195 DEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARL 1254

Query: 2204 EITNLEEQLEQFREELENK---------NEEVQQLHMQLEIQKKESTTRLQELEQENKLF 2254
            E  N  + L Q  + L  +          E+  +  +QL+  K +    ++  +QE++  
Sbjct: 1255 EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNM 1314

Query: 2255 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2314
            ++   ++ L +K  + + +  +     K AQ +    ++I++L  Q  KL ++L    D 
Sbjct: 1315 ENKTLEMELKLKGLEELISTLKDT---KGAQKVINWHMKIEELRLQELKLNREL--VKDK 1369

Query: 2315 KVIEEKNELIRDLETQIECLMSDQECVKRN------------REEEIEQLNEVIEKLQQE 2362
            + I+  N +I + E  I  L  ++E V++N            RE ++E+  ++ ++ Q E
Sbjct: 1370 EEIKYLNNIISEYERTISSL--EEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNE 1427

Query: 2363 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422
            + N  QK      S+ + +  L +QL++ + +   +++ +            ++ ET   
Sbjct: 1428 ILNAAQKFEEATGSIPDPSLPLPNQLEIALRK---IKENIR-----------IILETRAT 1473

Query: 2423 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP---ELEVVLTEDALKSLEN 2479
               L ++L    +E+ES  ++      S +  I+ L    P   E E ++ E   K +E 
Sbjct: 1474 CKSLEEKL----KEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP 1529

Query: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
            +++     +    +I N++ RL Q E  +           K+ + + E+ + E   + KK
Sbjct: 1530 KSHHTL--KIAHQTIANMQARLNQKEEVL-----------KKYQRLLEKAREEQREIVKK 1576

Query: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS 2599
                     E+    L  +++L+A     KF Q    +  +       N + +R  E+  
Sbjct: 1577 --------HEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ 1628

Query: 2600 DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659
             ++     +S L  ++ ++   L   + Q EI E  V E E   L+LQ+          E
Sbjct: 1629 TVAEQDDSLSSLLVKLKKVSQDL---ERQREITELKVKEFENIKLQLQE--------NHE 1677

Query: 2660 KEKKRSPQDVEVLKTTTELFHSNEESGFF-NELEALRAESVATKAELASYKEKAEKLQEE 2718
             E K+   +VE LK   +   S +ES    +EL+A +  +  ++A   + +   E+L+ +
Sbjct: 1678 DEVKKVKAEVEDLKYLLD--QSQKESQCLKSELQAQKEAN--SRAPTTTMRNLVERLKSQ 1733

Query: 2719 LLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL---EKEDETEVQESKKACMFEPLPIKLS 2775
            L +KE    +L + L ++R  +  A E+  I    +KE    VQ+     + +    +L 
Sbjct: 1734 LALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ-----IVDRHTRELK 1788

Query: 2776 KSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQE-- 2833
              +    +  LK+  + +T               S+     +T+ ++    +++K Q+  
Sbjct: 1789 TQVEDLNENLLKLKEALKT---------------SKNRENSLTDNLNDLNNELQKKQKAY 1833

Query: 2834 ---LHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELA 2890
               L   E +D E+  +               L   +   ++ + + ++  E     ++ 
Sbjct: 1834 NKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVE 1893

Query: 2891 HSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG---RGEESESATDSFPKKIKGLL 2947
              D    +E  + +    W +G      + +    EG   + +E E    +  K++  L 
Sbjct: 1894 EVDLKPMKEKNAKEELIRWEEG------KKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLK 1947

Query: 2948 RAVHNEGMQVLSLTESPYSDGEDHSIQQV-------SEPWLEE-RKAYINTISSLKDLIT 2999
                    + L+L     + G   ++ QV       SE  LEE +K  ++  + +  +  
Sbjct: 1948 DLFAKADKEKLTLQRKLKTTGM--TVDQVLGIRALESEKELEELKKRNLDLENDILYMRA 2005

Query: 3000 KMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVG 3059
               L R++ V D    +        E L AL++ F ++        +  ++ + + D   
Sbjct: 2006 HQALPRDSVVEDLHLQNRYLQ----EKLHALEKQFSKD-----TYSKPSISGIESDDHCQ 2056

Query: 3060 LLNCLEQ---RIQEQGVEYQAAMECLQKADRRSLLSEIQAL------------------- 3097
                L++   ++  + +E +  +E   K D   L ++++ L                   
Sbjct: 2057 REQELQKENLKLSSENIELKFQLEQANK-DLPRLKNQVRDLKEMCEFLKKEKAEVQRKLG 2115

Query: 3098 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3157
            H + +GR      E E      + +   +Q++  Q+ +    L+S  ++   ++++    
Sbjct: 2116 HVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS--EKMANIEQENEKL 2173

Query: 3158 KMVVAELKSELA-QTKLELETTLKAQHKHLKELEAFRLEVKDKTD----------EVHLL 3206
            K  + +LK+ L  Q  +  E+  K   K + E E  R E+K +TD           + +L
Sbjct: 2174 KAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEIL 2233

Query: 3207 NDTLASE-QKKSRELQWA------LEKEKAKLGRS---EERDKEELEDLKFSLESQKQRN 3256
            N+ +  + ++  + LQ+A      LE   +K  +S       + +L++L+  +  + Q  
Sbjct: 2234 NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSI 2293

Query: 3257 LQLNLLLE---QQKQLLNESQQKIESQRML---YDAQLSEEQGRNLELQVLLESEKVRIR 3310
              L  L++   +++Q +N+  + +E Q  +          EQG   ELQVL        R
Sbjct: 2294 TDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVL--------R 2345

Query: 3311 EMSSTLDRER-ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY 3369
              +  LD+E+ EL  Q++++     +   +P  D LKE  K LE +  ++ +L  E +  
Sbjct: 2346 LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQ-LKMSDL--EKQHL 2402

Query: 3370 KLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQL 3419
            K +  + ++++E       + ++  +    E  KK   L+ KV+ L  QL
Sbjct: 2403 KEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452



 Score =  176 bits (447), Expect = 3e-43
 Identities = 460/2455 (18%), Positives = 1011/2455 (41%), Gaps = 350/2455 (14%)

Query: 492  NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551
            N+ I+   +++ +  S+K++    L  I +    ++ Q      E+  + E++++A +  
Sbjct: 27   NLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQ------EVELALEEVEKAGEEQ 80

Query: 552  AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
            A+ E++L       + V  L+ E+  A +S    + +    + N   +LE   ++K+  L
Sbjct: 81   AKFENQLK------TKVMKLENELEMAQQSAGGRDTRF---LRNEICQLEKQLEQKDREL 131

Query: 612  DRMAESQEAELERLRTQLLFSHEE---ELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
            + M +  E E +++  QL   +EE   E SKL+ + +   + N +  +D   I Y++QID
Sbjct: 132  EDMEKELEKE-KKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI--IDYQKQID 188

Query: 669  GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728
                           +K+ L++++ +     S+L      L+    E  TL   E  ++I
Sbjct: 189  S--------------QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTL--TEANEKI 232

Query: 729  EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE 788
            E+  QE ++   LE+ VQE++  T+   + MK   +       QL+ EN   + + + L 
Sbjct: 233  EVQNQEMRKN--LEESVQEMEKMTDEYNR-MKAIVHQTDNVIDQLKKENDHYQLQVQELT 289

Query: 789  DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRN 848
            D+LK       EE    + ++ +K ++  W+    IL  +++++ +    L+   EK +N
Sbjct: 290  DLLKS----KNEEDDPIMVAVNAKVEE--WKL---ILSSKDDEIIEYQQMLHNLREKLKN 340

Query: 849  TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
                A+K+  +  Q+  +E    +K+  +  +   K+  +    ++ L  EL        
Sbjct: 341  AQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRN----- 395

Query: 909  TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ 968
              K  S++  +    +  TL++ +   K+     E  E   REK    + L +  ++LK 
Sbjct: 396  --KGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREK---DKELVEALKRLKD 450

Query: 969  KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTS 1028
                +  L + V  +K  K Q+ +R RE+EI+      + +   + ++S  LD    +  
Sbjct: 451  YESGVYGLEDAVVEIKNCKNQIKIRDREIEIL-----TKEINKLELKISDFLDENEALRE 505

Query: 1029 RGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQ-EQLILDHLPSVTKESSLRAT 1087
            R      + ++ +    SK + + +   EN  + +E +  E+  LD    + + +  R  
Sbjct: 506  RVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGK 565

Query: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147
            + + +    ++LN+ ++     R+  E +   LSL   +      E+           L 
Sbjct: 566  RSATSGLTTEDLNLTENISQGDRIS-ERKLDLLSLKNMSEAQSKNEF-----------LS 613

Query: 1148 EELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206
             ELI    EK ++L++   +  +   K +E  +E K L   + ++ +A+ E     +Q  
Sbjct: 614  RELI----EKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE-----MQKD 664

Query: 1207 CSVLG---EYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKV 1263
              V G       P+L+  VNA + +N+        D  L   + +V         L  ++
Sbjct: 665  PDVKGGETSLIIPSLERLVNAIESKNAEGIF----DASLH-LKAQVDQLTGRNEELRQEL 719

Query: 1264 TEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-ENLPKEETEFLSIHSQMTNLEDIDVNHK 1322
             E   + +    +L+K        +K++  E E     ++E  ++  +  +L D      
Sbjct: 720  RESRKEAINYSQQLAKA------NLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSS 773

Query: 1323 SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPP 1382
            + + + Q+     L ++++  E  + +L+  L++  + +    H  Q+ L      +   
Sbjct: 774  ASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRH--QQSLLYKEYLSEKE 831

Query: 1383 SLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442
            +   +S  I E             K+ ++  ++      VKE  N++  L+        +
Sbjct: 832  TWKTESKTIKEE------------KRKLEDQVQ-QDAIKVKEYNNLLNALQMD-----SD 873

Query: 1443 EVAKVIV--SMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQ-DQIG 1499
            E+ K++   S  I   Q  E S I          +Q     +++++    M+    ++IG
Sbjct: 874  EMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIG 933

Query: 1500 -FQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558
              Q F+ + + FK        +      E+ L+N   +++            ++  KD  
Sbjct: 934  CLQRFKEMAI-FKIAALQKVVDNSVSLSELELANKQYNELTAKY-------RDILQKDNM 985

Query: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
             + R S  + +   ++    Q+    ++LE  +++L    Q  +Q T+L  ++ M + ++
Sbjct: 986  LVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKK 1045

Query: 1619 Q--REDQEQLQEEIKRLN-RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLC 1675
                 D   + ++I  L  ++L +R   ++   + E  R  L+++E              
Sbjct: 1046 SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE------------- 1092

Query: 1676 CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735
               RN   +T+     +  ++ Q  ++   D   + V   +   +R  + +     +++ 
Sbjct: 1093 ---RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELK 1149

Query: 1736 LEVVKTTAAVEETIGRHVLGILDRSSKS-----QSSASLIWRSEAEASVKSCVHEEHTRV 1790
            +EV K     +  I R  + IL+   +S     +S    +   +A++  KS + + H   
Sbjct: 1150 VEVSKLREISD--IARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHN 1207

Query: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRL 1850
                +   +      +  +   K+      L Q+L            E E+ +       
Sbjct: 1208 VSLQLSEATALGKLESITSKLQKMEAYNLRLEQKL-----------DEKEQALYYARLEG 1256

Query: 1851 QAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRA 1909
            +   + L + I     Q   A  + Q E   ++  Q Q   + LK  +E++    E    
Sbjct: 1257 RNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN--DKLKIMQEMKNSQQEHRNM 1314

Query: 1910 RE---QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQ 1966
                 ++ ++L   E +I    D K                  Q+++    +++EL  ++
Sbjct: 1315 ENKTLEMELKLKGLEELISTLKDTKGA----------------QKVINWHMKIEELRLQE 1358

Query: 1967 QQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKAL 2026
             ++  E   L + KE +K         ++ E E+ +    E   Q  K  ++ Q      
Sbjct: 1359 LKLNRE---LVKDKEEIK-----YLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQR 1410

Query: 2027 EIDVEEQVSRFIELEQEKNTELMDLRQQNQALE--KQLEKMRKFLDEQAIDREHERDVFQ 2084
            E+D+E Q+  F              RQQN+ L   ++ E+    + + ++   ++ ++  
Sbjct: 1411 EVDLERQLDIFD-------------RQQNEILNAAQKFEEATGSIPDPSLPLPNQLEI-- 1455

Query: 2085 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 2144
              ++K+++ ++++            E       L+EK  +    L   EQ   +I  R++
Sbjct: 1456 -ALRKIKENIRII-----------LETRATCKSLEEKLKEKESALRLAEQ---NILSRDK 1500

Query: 2145 EIEKLEFRV-RELEQALLVSADTFQKVEDRKHFGAVEAKPELS-LEVQLQAERDAIDRKE 2202
             I +L  R+    E+  L++    +++E + H     A   ++ ++ +L  + + + + +
Sbjct: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560

Query: 2203 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE-----------N 2251
            +    LE+  E+ RE ++   E++  LH +LE+Q   S  + ++   +           N
Sbjct: 1561 RL---LEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTN 1617

Query: 2252 KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ--EKEVEIDQLN-EQVTKLQQQL 2308
            K F    E      ++ D++S+     L  K  ++ Q  E++ EI +L  ++   ++ QL
Sbjct: 1618 KHFIRLAEMEQTVAEQDDSLSS-----LLVKLKKVSQDLERQREITELKVKEFENIKLQL 1672

Query: 2309 KITTDNKV------IEEKNELIRDLETQIECLMSDQECVK-----------RN------- 2344
            +   +++V      +E+   L+   + + +CL S+ +  K           RN       
Sbjct: 1673 QENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKS 1732

Query: 2345 ----REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400
                +E++ + L+  + +L+ E+    ++  ++A S  E   +++  +D    E   L+ 
Sbjct: 1733 QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRE---LKT 1789

Query: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460
            QVE  NE +  +K  LK +  + N LT  L  L  E +  +K      N +    + + +
Sbjct: 1790 QVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY----NKILREKEEIDQ 1845

Query: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
            +  EL     +  +K L +    K   +N +  I  L+ ++ +LE+ +  K  E+     
Sbjct: 1846 ENDEL-----KRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPM 1900

Query: 2521 QIKDMQEQ--GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQE-YAKFCQDNQTI 2577
            + K+ +E+     E +  Q KI  ++  ++EK         QL  +++ +AK  ++  T+
Sbjct: 1901 KEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTL 1960

Query: 2578 SSEPERT--NIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKN 2635
              + + T   +  +  +R  E   ++  L  R  +LE+ ++ M     L ++ V + + +
Sbjct: 1961 QRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSV-VEDLH 2019

Query: 2636 VLEK--EKKLLELQKL-------------LEGNEKKQREKEKKRSPQDVEVLKTTTELFH 2680
            +  +  ++KL  L+K              +E ++  QRE+E ++     E LK ++E   
Sbjct: 2020 LQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQK-----ENLKLSSE--- 2071

Query: 2681 SNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH- 2739
             N E  F  +LE    +    K ++   KE  E L++E          +Q+ L  VR   
Sbjct: 2072 -NIELKF--QLEQANKDLPRLKNQVRDLKEMCEFLKKE-------KAEVQRKLGHVRGSG 2121

Query: 2740 -----LAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQT 2794
                 + E ++ + +++K  E   +E+++  + +   I  S+ +A+      K+ +  + 
Sbjct: 2122 RSGKTIPELEKTIGLMKKVVEKVQRENEQ--LKKASGILTSEKMANIEQENEKLKAELEK 2179

Query: 2795 PQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK--MQELHAAEILDMESRHI 2847
               L  + G Q+++  E  ++   +II++  E++ K   +E  AAE L +   ++
Sbjct: 2180 ---LKAHLGHQLSMHYESKTKGTEKIIAE-NERLRKELKKETDAAEKLRIAKNNL 2230



 Score =  171 bits (434), Expect = 1e-41
 Identities = 447/2333 (19%), Positives = 936/2333 (40%), Gaps = 369/2333 (15%)

Query: 1584 EEQLEDMRQELVRQYQEHQQA-----TELLR------QAHMRQMERQREDQEQLQEEIKR 1632
            E QL+    +L  + +  QQ+     T  LR      +  + Q +R+ ED E+  E+ K+
Sbjct: 84   ENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKK 143

Query: 1633 LNRQLAQRS-SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
            +N QLA R+   +NEN    RE   L++            E+LC          Q+  + 
Sbjct: 144  VNEQLALRNEEAENENSKLRRENKRLKK----------KNEQLC----------QDIIDY 183

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
            Q +++ Q  KE  L R+ ED      S+ R  L K N  L++ L E+   T A E+    
Sbjct: 184  QKQIDSQ--KETLLSRRGED------SDYRSQLSKKNYELIQYLDEIQTLTEANEKI--- 232

Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE------------EHTRVTDESIPSYS 1799
             V     R +  +S   +   ++    +K+ VH+            +H ++  + +    
Sbjct: 233  EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292

Query: 1800 GSDMPRND---------INMW----SKVTEEGTELSQRL--VRSGFAGTEIDPENEELML 1844
             S    +D         +  W    S   +E  E  Q L  +R      ++D +   +M 
Sbjct: 293  KSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMA 352

Query: 1845 ---NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEAT----------- 1890
                I  R  + ++ L E + + + ++E       +L  E  R K  +T           
Sbjct: 353  LQQGIQER-DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411

Query: 1891 ------ESLKCQEELRERLHEESRAREQLAVELSK--------AEGVIDGYADEKT---- 1932
                  E  K  E   E    ++R +++  VE  K          G+ D   + K     
Sbjct: 412  TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQ 471

Query: 1933 --LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL-----SRQKEAMKA 1985
              + +R+I+  T  I++LE ++   S+ L E EA ++++  E + +      R  + +K 
Sbjct: 472  IKIRDREIEILTKEINKLELKI---SDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528

Query: 1986 EAGPVEQQ-LLQETEKLMKEKLEVQCQAEKVRDDLQKQ-----VKALEIDVEEQVSRFIE 2039
            +    E Q LL+E E L +E+L+++ +  ++  +  K+     +   ++++ E +S+   
Sbjct: 529  QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588

Query: 2040 LEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPR 2099
            +  E+  +L+ L+  ++A  K      +FL  + I++E + +  +  I K + +LK +  
Sbjct: 589  I-SERKLDLLSLKNMSEAQSK-----NEFLSRELIEKERDLERSRTVIAKFQNKLKELVE 642

Query: 2100 FQPISEHQTREVEQLANHLKEKTD----KCSELLLSKEQLQRDIQERNEE---------- 2145
                 E   +E+ Q    +++  D    + S ++ S E+L   I+ +N E          
Sbjct: 643  ENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLK 702

Query: 2146 --IEKLEFRVRELEQALLVS---ADTFQKVEDRKHFGAVEAKPELSLEVQ---------- 2190
              +++L  R  EL Q L  S   A  + +   + +      + E SL  Q          
Sbjct: 703  AQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKG 762

Query: 2191 --------------LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2236
                          + ++ + +    +E+ N E++L+   + LE+ N +   +  Q  + 
Sbjct: 763  IDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLL 822

Query: 2237 KKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
             KE  +  +  + E+K  K++  KL   +++ DA+  ++ + L         E +  + +
Sbjct: 823  YKEYLSEKETWKTESKTIKEEKRKLEDQVQQ-DAIKVKEYNNLLNALQMDSDEMKKILAE 881

Query: 2297 LNEQVTKLQQQLK--ITTDNKVIEEKNELIRDLETQIECLMSDQE-------CVKRNRE- 2346
             + ++T LQ   K  I     ++E + +L ++ E Q   L+S +        C++R +E 
Sbjct: 882  NSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEM 941

Query: 2347 ------------------EEIEQLNEVIEKLQQELANIGQKTSMNAH------------- 2375
                               E+E  N+   +L  +  +I QK +M                
Sbjct: 942  AIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENI 1001

Query: 2376 SLSEEADSLKHQLDVVIAEKL-----ALEQQVETANEEMTFMKNVLKETNFKMNQLTQEL 2430
            SL E+ +S+  +L++   EKL     A EQ+ +  NE  +  K     TN  +  +++++
Sbjct: 1002 SLKEQVESINKELEIT-KEKLHTIEQAWEQETKLGNES-SMDKAKKSITNSDIVSISKKI 1059

Query: 2431 FSLK----RERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ------ 2480
              L+     ER+  E  Q + E+ +  ++  + +   ELE    E    +L+ Q      
Sbjct: 1060 TMLEMKELNERQRAEHCQKMYEH-LRTSLKQMEERNFELETKFAELTKINLDAQKVEQML 1118

Query: 2481 ------TYFKSFEENGKGSIINLETRLLQLESTVS--AKDLELTQCYKQIKDMQEQGQ-F 2531
                  +  K+  +  +  I+ LE   ++L+  VS   +  ++ +   +I + Q+Q +  
Sbjct: 1119 RDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDK 1178

Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
            E E L+ ++++ Q   +EK   A + Q  +      A      ++I+S+ ++    NL  
Sbjct: 1179 EVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLR- 1237

Query: 2592 LREDELGSDISALTLRISELESQVVEMHTSL---------ILEKEQVEIAEKNVLEKEKK 2642
              E +L     AL     E  ++   +  ++          L   Q E   K +++ +  
Sbjct: 1238 -LEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQND 1296

Query: 2643 LLELQKLLEGNEKKQREKEKKRSPQDV------EVLKTTTELFHSNEESGFFNELEALRA 2696
             L++ + ++ ++++ R  E K    ++      E++ T  +   + +   +  ++E LR 
Sbjct: 1297 KLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRL 1356

Query: 2697 ESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2756
            + +    EL   KE+ + L   +   E  ++SL++++ Q      E +         D+ 
Sbjct: 1357 QELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAW------DQR 1410

Query: 2757 EVQESKKACMFE-------PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQ 2809
            EV   ++  +F+           K  ++  S  D +L + +  +     +K   I+I L+
Sbjct: 1411 EVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKE-NIRIILE 1469

Query: 2810 SECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE--- 2866
            +  + + + E + +    +   ++   +    +    +    T +RE  +A    KE   
Sbjct: 1470 TRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP 1529

Query: 2867 -ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIAS 2925
                TLK   Q + + +     +      YQ       +   +  + I   H +   I  
Sbjct: 1530 KSHHTLKIAHQTIANMQARLNQKEEVLKKYQR----LLEKAREEQREIVKKHEEDLHILH 1585

Query: 2926 EGRGEESESATDSFPKKIKGLLR-----AVHNEGMQVLSLTESPYSDGEDH------SIQ 2974
                 +++S+ + F +    L++        N+    L+  E   ++ +D        ++
Sbjct: 1586 HRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLK 1645

Query: 2975 QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF 3034
            +VS+    +R+     +   +++  ++Q   E EV       E       + LL   Q  
Sbjct: 1646 KVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL-----KYLLDQSQ-- 1698

Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI 3094
             +E   L +  + +  A        + N +E R++ Q     A  E  QKA  R+LL   
Sbjct: 1699 -KESQCLKSELQAQKEANSRAPTTTMRNLVE-RLKSQ----LALKEKQQKALSRALLELR 1752

Query: 3095 QALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQL 3154
              + A    R I+   ++E+    Q++++ + +       E++ ++  + +   +L+E L
Sbjct: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTR-------ELKTQVEDLNENLLKLKEAL 1805

Query: 3155 SSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ 3214
             + K     L   L     EL+   KA +K L+E E    E  +   ++  L   L  + 
Sbjct: 1806 KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKP 1865

Query: 3215 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3274
                + Q  +E+ + K+ + E + + ++E++   L+  K++N +  L+  ++ +   + Q
Sbjct: 1866 LTDNK-QSLIEELQRKVKKLENQLEGKVEEV--DLKPMKEKNAKEELIRWEEGK---KWQ 1919

Query: 3275 QKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRER-ELHAQLQSSDGTG 3333
             KIE  R     +L E++G    L   L +    ++++ +  D+E+  L  +L++   TG
Sbjct: 1920 AKIEGIR----NKLKEKEGEVFTLTKQLNT----LKDLFAKADKEKLTLQRKLKT---TG 1968

Query: 3334 QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3393
             +   +     L E +K+LEE   R ++L N+     +  ++  Q + +D  V    LQ 
Sbjct: 1969 MTVDQVLGIRAL-ESEKELEELKKRNLDLEND-----ILYMRAHQALPRDSVVEDLHLQN 2022

Query: 3394 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREE 3452
                          LQ K+  L++Q  +       +  +E        QE QK+ L+   
Sbjct: 2023 RY------------LQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSS 2070

Query: 3453 KRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHEL 3512
            +    +   +  N+         R +N V   K   E  +   A++    G   G     
Sbjct: 2071 ENIELKFQLEQANKDL------PRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSG 2124

Query: 3513 EMIRQKLQCVASKLQVLPQKASERLQFETAD----DEDFIWVQENIDEIILQLQKLTGQQ 3568
            + I +  + +    +V+ +   E  Q + A      E    +++  +++  +L+KL    
Sbjct: 2125 KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHL 2184

Query: 3569 GEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLR----NMVMKLEEQIRWYR 3624
            G + S+   S + G  TE+++ +N  L   + + T+    LR    N+ +  E+      
Sbjct: 2185 GHQLSMHYESKTKG--TEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLE 2242

Query: 3625 QTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLT--LQKSLKRAEAEVYK 3675
            +TG       +F+ + G  +E    ++ + W    +T   +  LK  E ++ K
Sbjct: 2243 ETG----KRLQFAESRGPQLE---GADSKSWKSIVVTRMYETKLKELETDIAK 2288



 Score =  165 bits (418), Expect = 7e-40
 Identities = 484/2440 (19%), Positives = 978/2440 (40%), Gaps = 396/2440 (16%)

Query: 1331 LEKTKLEEQVQELESLISSLQQQLKETEQ----NYEAE-----IHCLQKRLQAVSESTVP 1381
            LEK +LE++ +ELE +   L+++ K  EQ    N EAE     +    KRL+  +E    
Sbjct: 120  LEK-QLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQ 178

Query: 1382 PSLPVDSVVITESDA------QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNI-VKLLEK 1434
              +     + ++ +       + + Y     KKN +  I++  E     E N  +++  +
Sbjct: 179  DIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYE-LIQYLDEIQTLTEANEKIEVQNQ 237

Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494
            + ++ LEE V ++                    ++ T    +  A+  Q  +  +++K  
Sbjct: 238  EMRKNLEESVQEM--------------------EKMTDEYNRMKAIVHQTDNVIDQLKKE 277

Query: 1495 QDQIGFQTFETVDV--KFKEEFKPLSKELGEHGKE--ILLSNSDPHDIPESKDCVLTISE 1550
             D    Q  E  D+     EE  P+   +    +E  ++LS+ D  +I E +  +  + E
Sbjct: 278  NDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDD-EIIEYQQMLHNLRE 336

Query: 1551 EMFS------KDKTFIVRQSIHDEISVSSM------DASRQLMLNEEQLEDMRQELVRQY 1598
            ++ +      K     ++Q I +  S   M        ++++  N   +ED++ EL    
Sbjct: 337  KLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNEL---- 392

Query: 1599 QEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLE 1658
            Q ++ A+ L +Q HM+     +   + L+E+ K      A+R++   E    E+++ L+E
Sbjct: 393  QRNKGASTLSQQTHMKI----QSTLDILKEKTKE-----AERTAELAEADAREKDKELVE 443

Query: 1659 ELEALK--QLSLAGREKLCCELRNSSTQTQNGNE---------NQGEVEEQTF-KEKELD 1706
             L+ LK  +  + G E    E++N   Q +  +          N+ E++   F  E E  
Sbjct: 444  ALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEAL 503

Query: 1707 RKPEDVPPEIL------SNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
            R+   + P+ +       N ++  Q+      +ILL+ +++       + + +  +    
Sbjct: 504  RERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820
             K  +++ L   +  + ++   +  +  R+++  +   S  +M          ++ E  E
Sbjct: 564  GKRSATSGL---TTEDLNLTENI-SQGDRISERKLDLLSLKNMSEAQSKN-EFLSRELIE 618

Query: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880
              + L RS     +   + +EL+   + +L+  ++++L+AI E     +  K  +T L+ 
Sbjct: 619  KERDLERSRTVIAKFQNKLKELVEE-NKQLEEGMKEILQAIKEMQKDPD-VKGGETSLII 676

Query: 1881 ESFRQKQEATES------------LKCQ--------EELRERLHEESRAREQLAVELSKA 1920
             S  +   A ES            LK Q        EELR+ L E  +     + +L+KA
Sbjct: 677  PSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKA 736

Query: 1921 EGVIDGYADEKTLFERQ----------------IQEKTDIIDRLEQELLCASNRLQELEA 1964
               ID    E +L  +                       II+   + L+     L+  E 
Sbjct: 737  NLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEK 796

Query: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ-- 2022
            + + +++  E  +R+   ++ +   + ++ L E E    E   ++ +  K+ D +Q+   
Sbjct: 797  KLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAI 856

Query: 2023 --------VKALEIDVEE------QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKF 2068
                    + AL++D +E      + SR I + Q     L+        LE+QL K  + 
Sbjct: 857  KVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEK 916

Query: 2069 LDEQAIDREHE--------RDVFQQEIQKLEQQLKVVPRFQPISEHQT------------ 2108
               + +  E E        +   +  I K+    KVV     +SE +             
Sbjct: 917  QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKY 976

Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV------ 2162
            R++ Q  N L ++T     L      L+  ++  N+E+E  + ++  +EQA         
Sbjct: 977  RDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGN 1036

Query: 2163 --SADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE--- 2217
              S D  +K        ++  K  + LE++   ER   +  +K   +L   L+Q  E   
Sbjct: 1037 ESSMDKAKKSITNSDIVSISKKITM-LEMKELNERQRAEHCQKMYEHLRTSLKQMEERNF 1095

Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
            ELE K  E+ +++  L+ QK E   R +  +  +K   D   +  L +++++     +  
Sbjct: 1096 ELETKFAELTKIN--LDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNE----MELK 1149

Query: 2278 VLFGKFAQI--IQEKEVEIDQLNEQ-----VTKLQQQLKITTDNKVIEEKNELIRDL-ET 2329
            V   K  +I  I  ++VEI    +Q     V  L+ QL    D +   ++  LI  L + 
Sbjct: 1150 VEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQL---LDYQAQSDEKSLIAKLHQH 1206

Query: 2330 QIECLMSDQECVKR-----NREEEIE----QLNEVIEKLQQELANIGQKTSMNAHSLSEE 2380
             +   +S+   + +     ++ +++E    +L + +++ +Q L     +    A  L + 
Sbjct: 1207 NVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQT 1266

Query: 2381 ADSLKHQLDVVIA----------------EKLALEQQVETANEEMTFMKNVLKETNFKMN 2424
              SL+ Q    +                 +KL + Q+++ + +E   M+N   E   K+ 
Sbjct: 1267 IQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLK 1326

Query: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPEL-EVVLTEDALKSLENQTYF 2483
             L +EL S  ++ +  +K+ +           H+  ++  L E+ L  + +K  E   Y 
Sbjct: 1327 GL-EELISTLKDTKGAQKVINW----------HMKIEELRLQELKLNRELVKDKEEIKYL 1375

Query: 2484 KSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2543
             +     + +I +LE  ++Q       + +   Q  +++   ++   F+ +  Q +I+N 
Sbjct: 1376 NNIISEYERTISSLEEEIVQQNKFHEERQMAWDQ--REVDLERQLDIFDRQ--QNEILNA 1431

Query: 2544 QKIVEEKVAAALVSQIQLEAVQEYA-KFCQDNQTISSEPERTNIQNLNQLREDE------ 2596
             +  EE   +     + L    E A +  ++N  I  E   T      +L+E E      
Sbjct: 1432 AQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491

Query: 2597 ----LGSD--ISALTLRI---SELESQVVEM---------HTSLILEKEQVEIAEKNVLE 2638
                L  D  I+ L LR+   +E E  + E+         H +L +  + +   +  + +
Sbjct: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ 1551

Query: 2639 KEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAES 2698
            KE+ L + Q+LLE   ++QRE  KK   +D+ +L    EL   +  + F      L  +S
Sbjct: 1552 KEEVLKKYQRLLEKAREEQREIVKKHE-EDLHILHHRLELQADSSLNKFKQTAWDLMKQS 1610

Query: 2699 VATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET-- 2756
              T      +  +  ++++ +  ++ +++SL   L +V   L   +E   +  KE E   
Sbjct: 1611 -PTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIK 1669

Query: 2757 -EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSE 2815
             ++QE+ +         ++ K  A   D    +  S +  Q L      ++  Q E +S 
Sbjct: 1670 LQLQENHED--------EVKKVKAEVEDLKYLLDQSQKESQCLKS----ELQAQKEANSR 1717

Query: 2816 EVTEIISQFTEKI-------EKMQELHAAEILDM--------ESRHISETETLKREHYVA 2860
              T  +    E++       EK Q+  +  +L++        E R IS T   K  H   
Sbjct: 1718 APTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQ-KEAHLNV 1776

Query: 2861 VQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQG 2920
             Q++      LK  ++ L          L  S   + RE   +D+ +D    +       
Sbjct: 1777 QQIVDRHTRELKTQVEDLNENLLKLKEALKTS---KNRENSLTDNLNDLNNELQKKQKAY 1833

Query: 2921 FDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED--HSIQQVSE 2978
              I  E   EE +   D   ++IK L       G+Q   LT++  S  E+    ++++ E
Sbjct: 1834 NKILREK--EEIDQENDELKRQIKRL-----TSGLQGKPLTDNKQSLIEELQRKVKKL-E 1885

Query: 2979 PWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESF----SDWRGEL------LL 3028
              LE +   ++ +  +K+   K +L R  E        E       +  GE+      L 
Sbjct: 1886 NQLEGKVEEVD-LKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLN 1944

Query: 3029 ALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQ-----------EQGVEYQA 3077
             L+ +F +     L   R   T   T D V  +  LE   +           E  + Y  
Sbjct: 1945 TLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMR 2004

Query: 3078 AMECLQK--------ADRRSLLSEIQALHAQMNGRKIT------------LKREQESEKP 3117
            A + L +           R L  ++ AL  Q +    +             +REQE +K 
Sbjct: 2005 AHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKE 2064

Query: 3118 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA-------- 3169
            + +L   NI+ K  Q+ +   +L  +K++  +L+E     K   AE++ +L         
Sbjct: 2065 NLKLSSENIELK-FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS 2123

Query: 3170 -QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEK 3228
             +T  ELE T+    K +++++    ++K  +    L ++ +A+ ++++ +L+  LEK K
Sbjct: 2124 GKTIPELEKTIGLMKKVVEKVQRENEQLKKASGI--LTSEKMANIEQENEKLKAELEKLK 2181

Query: 3229 AKLGR-------SEERDKEEL--EDLKFSLESQKQRNLQLNLLLEQQK-QLLNESQQKIE 3278
            A LG        S+ +  E++  E+ +   E +K+ +    L + +   ++LNE +  ++
Sbjct: 2182 AHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNE-KMTVQ 2240

Query: 3279 SQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPP 3338
             +      Q +E +G  LE       + + +  M  T  +E E     ++   T   +  
Sbjct: 2241 LEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLV 2300

Query: 3339 LPSEDLLKELQKQLEEKHSRIVELLN-----ETEKYKLDSLQT----RQQMEKDRQ--VH 3387
              + +  +++ K  E+   +I  L +     ETE+     LQ       Q++K++   +H
Sbjct: 2301 KEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIH 2360

Query: 3388 RKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE 3447
            +     +Q           +L+ K++DL+ QL+         DLE Q L+  +++  K+E
Sbjct: 2361 QIEANKDQSGAESTIPDADQLKEKIKDLETQLKMS-------DLEKQHLKEEIKKL-KKE 2412

Query: 3448 LEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE 3487
            LE  +      I      E   ++   +  +N +L++K++
Sbjct: 2413 LENFDPSFFEEI------EDLKYNYKEEVKKNILLEEKVK 2446



 Score =  165 bits (417), Expect = 9e-40
 Identities = 425/2116 (20%), Positives = 856/2116 (40%), Gaps = 383/2116 (18%)

Query: 1838 ENEEL---MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR--ESFRQKQEATES 1892
            +NE+L   +++   ++ +  E LL    E S           EL++  +  +   EA E 
Sbjct: 172  KNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEK 231

Query: 1893 LKCQ-EELRERLHEESRAREQLAVELSK-------AEGVIDGYADEKTLFERQIQEKTDI 1944
            ++ Q +E+R+ L E  +  E++  E ++        + VID    E   ++ Q+QE TD+
Sbjct: 232  IEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL 291

Query: 1945 ID---------------RLEQELLCASNRLQELEAEQQQIQEERELLSR-QKEAMKAEAG 1988
            +                ++E+  L  S++  E+   QQ +   RE L   Q +A K+   
Sbjct: 292  LKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVM 351

Query: 1989 PVEQ----------QLLQETEKLMKEKLEVQCQAEKVRDDLQ--KQVKALEIDVEEQVSR 2036
             ++Q           L ++ E+  KE  +  C  E ++++LQ  K    L      ++  
Sbjct: 352  ALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411

Query: 2037 FIELEQEKNTEL--------MDLRQQNQALEKQLEKMRKF------LDEQAID------- 2075
             +++ +EK  E          D R++++ L + L++++ +      L++  ++       
Sbjct: 412  TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQ 471

Query: 2076 ---REHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132
               R+ E ++  +EI KLE ++     F   +E     V      + + T+  +   L +
Sbjct: 472  IKIRDREIEILTKEINKLELKIS---DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528

Query: 2133 EQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA--KPELSLEVQ 2190
            +Q + + Q   +EIE LE      E+ L +     Q  ++R    A       +L+L   
Sbjct: 529  QQYRAENQILLKEIESLE------EERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTEN 582

Query: 2191 LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT-------R 2243
            + ++ D I  ++ ++ +L+        E ++KNE + +  ++ E   + S T       +
Sbjct: 583  I-SQGDRISERKLDLLSLKNM-----SEAQSKNEFLSRELIEKERDLERSRTVIAKFQNK 636

Query: 2244 LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE------------ 2291
            L+EL +ENK  ++ M+++  AIKE      +D  V  G+ + II   E            
Sbjct: 637  LKELVEENKQLEEGMKEILQAIKEMQ----KDPDVKGGETSLIIPSLERLVNAIESKNAE 692

Query: 2292 ----------VEIDQLNEQVTKLQQQLKITTDNKV-----IEEKNELIRDLETQIECLMS 2336
                       ++DQL  +  +L+Q+L+ +    +     + + N  I  LE +   L  
Sbjct: 693  GIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQ 752

Query: 2337 DQ------------ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE---EA 2381
             +            + +  +    I   NE +  L QEL N  +K      SL +   + 
Sbjct: 753  SEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKF 812

Query: 2382 DSLKHQLDVV----IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER 2437
              ++HQ  ++    ++EK   + + +T  EE   +++ +++   K+ +    L +L+ + 
Sbjct: 813  AVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDS 872

Query: 2438 ESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINL 2497
            + ++KI  + ENS  + +  ++    E  ++     L  LE Q   +   E  K  ++++
Sbjct: 873  DEMKKI--LAENSRKITVLQVN----EKSLIRQYTTLVELERQ--LRKENEKQKNELLSM 924

Query: 2498 ETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA--- 2554
            E           A+  E   C ++ K          EM   KI  LQK+V+  V+ +   
Sbjct: 925  E-----------AEVCEKIGCLQRFK----------EMAIFKIAALQKVVDNSVSLSELE 963

Query: 2555 LVSQIQLEAVQEYAKFCQ-DNQTI--SSEPERTNIQNLNQLREDE-LGSDISALTLRISE 2610
            L ++   E   +Y    Q DN  +  +S  E    +N++   + E +  ++     ++  
Sbjct: 964  LANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHT 1023

Query: 2611 LESQVVEMHTSL----ILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSP 2666
            +E Q  E  T L     ++K +  I   +++   KK+  L+ + E NE+++ E  +K   
Sbjct: 1024 IE-QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLE-MKELNERQRAEHCQKM-- 1079

Query: 2667 QDVEVLKTTTELFHSNE---ESGFFN----ELEALRAESVATKAELASYKEKA--EKLQE 2717
               E L+T+ +         E+ F       L+A + E +  + ELA    KA  +  ++
Sbjct: 1080 --YEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQML-RDELADSVSKAVSDADRQ 1136

Query: 2718 ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKS 2777
             +L  E N   L+ ++S++R+    A+ ++ IL  + ++  +E       E L ++L   
Sbjct: 1137 RILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKE------VESLRMQLLDY 1190

Query: 2778 IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIIS-QFTEKI-EKMQELH 2835
             A   + +L          + +  A     L+S  S  +  E  + +  +K+ EK Q L+
Sbjct: 1191 QAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALY 1250

Query: 2836 AAEILDME-SRHISET-ETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSD 2893
             A +     ++H+ +T ++L+R+   A+ L ++E  + K +IQ L++ +   + E+ +S 
Sbjct: 1251 YARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFS-KTMIQ-LQNDKLKIMQEMKNSQ 1308

Query: 2894 AYQTR----------------EICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATD 2937
                                 E+ S+   +   Q +   H +  ++  +      E   D
Sbjct: 1309 QEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKD 1368

Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDL 2997
               ++IK L   +      + SL E      + H  +Q++  W +               
Sbjct: 1369 K--EEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMA--WDQR-------------- 1410

Query: 2998 ITKMQLQREAEVYDSSQSH-----ESFSDWRG-----------ELLLALQQVFLEERSVL 3041
              ++ L+R+ +++D  Q+      + F +  G           +L +AL+++    R +L
Sbjct: 1411 --EVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIIL 1468

Query: 3042 LAAFRTELTALGTTDAVGLLNCLEQRIQEQG-VEYQAAMECLQKADRRSLLSEI------ 3094
                  +       +    L   EQ I  +  V  +  +     A+R  L++E+      
Sbjct: 1469 ETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEME 1528

Query: 3095 -------QALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS-------------QML 3134
                   +  H  +   +  L +++E  K  Q LLE   ++++                L
Sbjct: 1529 PKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRL 1588

Query: 3135 EMQVE--LSSMKDRATELQEQ-------------LSSEKMVVAE-------LKSELAQTK 3172
            E+Q +  L+  K  A +L +Q             L+  +  VAE       L  +L +  
Sbjct: 1589 ELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVS 1648

Query: 3173 LELETTLKAQHKHLKELEAFRL--------EVKDKTDEVHLLNDTLASEQKKSRELQWAL 3224
             +LE   +     +KE E  +L        EVK    EV  L   L   QK+S+ L+  L
Sbjct: 1649 QDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSEL 1708

Query: 3225 EKEKAKLGRSEERDKEEL-EDLKFSLE-SQKQRNLQLNLLLEQQKQLLNESQQKIESQRM 3282
            + +K    R+       L E LK  L   +KQ+      LLE + ++   ++++I S   
Sbjct: 1709 QAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATS 1768

Query: 3283 LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE 3342
              +A L+ +Q  +   + L    K ++ +++  L + +E    L++S     S       
Sbjct: 1769 QKEAHLNVQQIVDRHTREL----KTQVEDLNENLLKLKE---ALKTSKNRENS-----LT 1816

Query: 3343 DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG- 3401
            D L +L  +L++K     ++L E E+        ++  E  RQ+ R T   + +  T+  
Sbjct: 1817 DNLNDLNNELQKKQKAYNKILREKEEI------DQENDELKRQIKRLTSGLQGKPLTDNK 1870

Query: 3402 QKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI-- 3459
            Q  + ELQ KV+ L+ QLE K ++V   DL+  + +   +E  + E   E K+   +I  
Sbjct: 1871 QSLIEELQRKVKKLENQLEGKVEEV---DLKPMKEKNAKEELIRWE---EGKKWQAKIEG 1924

Query: 3460 LYQNLNEPTTWSLTSDRTRNWVL-------QQKIEGETKESNYAKLIEMNGGGTGCNHEL 3512
            +   L E      T  +  N +        ++K+  + K       ++   G      E 
Sbjct: 1925 IRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEK 1984

Query: 3513 EMIRQKLQCVASKLQVLPQKASERLQFETADDEDFI---WVQENIDEIILQLQKLTGQQG 3569
            E+   K + +  +  +L  +A + L  ++  ++  +   ++QE +  +  Q  K T    
Sbjct: 1985 ELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDT---Y 2041

Query: 3570 EEPSL--VSPSTSCGSLTE------RLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3621
             +PS+  +     C    E      +L  +N EL   + Q  ++   L+N V  L+E   
Sbjct: 2042 SKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCE 2101

Query: 3622 WYRQ------------TGAGRDNSSRFSLNGGAN-----IEAIIASEKEVWNREKLTLQK 3664
            + ++             G+GR   +   L          +E +    +++     +   +
Sbjct: 2102 FLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSE 2161

Query: 3665 SLKRAEAEVYKLKAEL 3680
             +   E E  KLKAEL
Sbjct: 2162 KMANIEQENEKLKAEL 2177



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 147/697 (21%), Positives = 293/697 (42%), Gaps = 91/697 (13%)

Query: 3064 LEQRIQEQGV---EYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT--LKREQESEKPS 3118
            LE+ +QE      EY      + + D      + +  H Q+  +++T  LK + E + P 
Sbjct: 243  LEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPI 302

Query: 3119 QELLEYNIQQ-------KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3171
               +   +++       K  +++E Q  L +++++    Q  L ++K  V  L+  + + 
Sbjct: 303  MVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQ--LDADKSNVMALQQGIQER 360

Query: 3172 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALE--KEKA 3229
              +++   +   ++ KE+E     ++D  +E+          Q+   ++Q  L+  KEK 
Sbjct: 361  DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420

Query: 3230 KLGR---------SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQ 3280
            K            + E+DKE +E LK  L+  +     L   + + K   N  Q KI  +
Sbjct: 421  KEAERTAELAEADAREKDKELVEALK-RLKDYESGVYGLEDAVVEIKNCKN--QIKIRDR 477

Query: 3281 RMLYDAQLSEEQGRNLELQV---LLESEKVRIR---EMSSTLDRERELHAQLQSSDGTGQ 3334
             +    ++  ++   LEL++   L E+E +R R   E  + +D       + ++S    Q
Sbjct: 478  EI----EILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL-----TEFRNSKHLKQ 528

Query: 3335 SRPPLPSEDLLKELQKQLEEK---HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3391
             +    ++ LLKE++   EE+     +I ++  E  K    S  T + +     + +   
Sbjct: 529  QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588

Query: 3392 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451
             +E++ +    K M E QSK E L R+L EK + + +      + Q  ++E  ++  + E
Sbjct: 589  ISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLE 648

Query: 3452 E-KRESRRILYQNLNEP------TTWSLTS-DRTRNWVLQQKIEGETKESNYAKLIEMNG 3503
            E  +E  + + +   +P      T+  + S +R  N +  +  EG    S + K      
Sbjct: 649  EGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLK--AQVD 706

Query: 3504 GGTGCNHELEMIRQKL-QCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQ 3562
              TG N EL   RQ+L +     +    Q A   L+ +  + E  +  Q     ++ +  
Sbjct: 707  QLTGRNEEL---RQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGI 763

Query: 3563 KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRW 3622
             L       P  ++PS++       +  QN  L   + +L  ++  L+N+   LE+   +
Sbjct: 764  DL-------PDGIAPSSA-----SIINSQNEYLIHLLQELENKEKKLKNLEDSLED---Y 808

Query: 3623 YRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
             R+    R   S         +     SEKE W  E  T+++  ++ E +V +   +++ 
Sbjct: 809  NRKFAVIRHQQSL--------LYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKE 860

Query: 3683 -DSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQ 3718
             ++LL  L  DS+ +       K + AE+ RK  + Q
Sbjct: 861  YNNLLNALQMDSDEM-------KKILAENSRKITVLQ 890



 Score = 50.1 bits (118), Expect = 4e-05
 Identities = 76/388 (19%), Positives = 173/388 (44%), Gaps = 50/388 (12%)

Query: 170  EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDE-TMREF 228
            E  E+ R+L  +R + G  G + + E E  I     ++ ++    +Q ++     T  + 
Sbjct: 2106 EKAEVQRKLGHVRGS-GRSG-KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKM 2163

Query: 229  LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
              + ++++KL+ + ++L+A    + S H  +     +  ++I+   ++L ++     D  
Sbjct: 2164 ANIEQENEKLKAELEKLKAHLGHQLSMHYESKT---KGTEKIIAENERLRKELKKETDAA 2220

Query: 289  KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----------------ETIIE 332
            +K       +  L EK+ V   E  K+++ +     Q +                ET ++
Sbjct: 2221 EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLK 2280

Query: 333  ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
            EL T I ++ +   +LK  +  A +     +EQ V K  E    ++++     +  ++ +
Sbjct: 2281 ELETDIAKKNQSITDLKQLVKEATE-----REQKVNKYNEDLEQQIKILKHVPEGAETEQ 2335

Query: 393  EIKQLMGTVEELQKRNHKDSQFETDIVQRME--------QETQRKLEQLRAELDEMYGQQ 444
             +K+    ++ L+  NH+  + + +++ ++E        + T    +QL+ ++ ++  Q 
Sbjct: 2336 GLKR---ELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL 2392

Query: 445  IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504
             +    +L +QH+   EE+K + K E+EN   S+       + +K       + NI L++
Sbjct: 2393 KMS---DLEKQHLK--EEIK-KLKKELENFDPSFFE---EIEDLKYNYKEEVKKNILLEE 2443

Query: 505  TNSQKEKLKEELGLILEEKCALQRQLED 532
               + +KL E+LG+ L    A   + ED
Sbjct: 2444 ---KVKKLSEQLGVELTSPVAASEEFED 2468



 Score = 37.0 bits (84), Expect = 0.38
 Identities = 40/158 (25%), Positives = 66/158 (41%), Gaps = 17/158 (10%)

Query: 3543 DDEDFIWVQENIDEIILQLQKLTGQQ--GEEPSLVSPSTSCGSLTERLLRQNAELT-GHI 3599
            D +D    +E  D +++ L K+   +   E+   V           ++  Q  EL    +
Sbjct: 14   DPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEV 73

Query: 3600 SQLTEEK----NDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIAS----- 3650
             +  EE+    N L+  VMKLE ++   +Q+  GRD  +RF  N    +E  +       
Sbjct: 74   EKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRD--TRFLRNEICQLEKQLEQKDREL 131

Query: 3651 ---EKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSL 3685
               EKE+   +K+  Q +L+  EAE    K    N  L
Sbjct: 132  EDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRL 169


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  239 bits (610), Expect = 4e-62
 Identities = 514/2583 (19%), Positives = 1073/2583 (41%), Gaps = 408/2583 (15%)

Query: 294  FTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLT 353
            F     +++    V E+  D+ +    ++EI + +  +EE++ +   +  +  +L   L 
Sbjct: 322  FASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLE 381

Query: 354  TADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQ 413
              D LL ++Q + ++    +      LT  ++ + +    +   +G + +++  N+ D  
Sbjct: 382  EKD-LLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYAD-- 438

Query: 414  FETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM------KTRH 467
             + +I   +  +T +    L  E+DE      V  + ++    +  + E+      K  +
Sbjct: 439  -QFNIPTNITTKTHKLSINLLREIDES-----VCSESDVFSNTLDTLSEIEWNPATKLLN 492

Query: 468  KGEMENALRS----YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEK 523
            +  +E+ L S    Y N+ ++ +Q++       E+ +KL++ N   E         LE K
Sbjct: 493  QENIESELNSLRADYDNLVLDYEQLRTEK---EEMELKLKEKNDLDEFEA------LERK 543

Query: 524  CALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRK 583
                ++++ L+ E+S  +  ++ A     + E++L+   + L   ED   ++    +S+K
Sbjct: 544  TKKDQEMQ-LIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQK 602

Query: 584  ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED 643
               +K +   +     LE +E  K           +  L    T  L +  E      E+
Sbjct: 603  LENIKMDLSYS-----LESIEDPKQ---------MKQTLFDAETVALDAKRESAFLRSEN 648

Query: 644  LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ----KIETMQFEKD-----NLITKQNQ 694
            LE++     EK+K+ L   YKQ  + +Q   SQ    K   +  EK+     N ITK   
Sbjct: 649  LELK-----EKMKE-LATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTS 702

Query: 695  LILEISKLKDLQQSL-VNSKSEEMTLQINELQKEIEILRQEE---KEKGTLEQEVQ---- 746
            LI +    KDL  +L +  K  ++  ++N+  +E E LR+E     E  +L  EV+    
Sbjct: 703  LI-DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRK 761

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            E+Q K+E L     EK+    E   +      +L++  KT +D+    +     ++    
Sbjct: 762  EIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF-- 819

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866
             + K+   D  +E++ ++++EENE + Q+ + L++E +K  ++    +       QELQE
Sbjct: 820  QNFKTLHMD--FEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQE 877

Query: 867  EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
                           K ++  E  ++++ L E+L  +     TV+ + ++  E      E
Sbjct: 878  ---------------KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLE 922

Query: 927  TLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE 986
             ++     + D  +L E L++      E  Q  SD+ + +         L   ++SLKQ 
Sbjct: 923  EVKTLTQEKDDLKQLQESLQI------ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQH 976

Query: 987  KEQVSLRCREL--EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVS-----KVN 1039
            +E ++    ++  E+  N +  EN      +    + G+       A+ + +     K N
Sbjct: 977  QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN 1036

Query: 1040 KSFGEESKI--MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQK 1097
            +   ++ KI  ++++K   + M     +++EQL  D   ++      +       D+L+K
Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096

Query: 1098 ELNVLKSEQND-LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEE 1156
            +  ++  E+N  ++ + E  R C  L       +V E ++ EK + L   +++L+  QEE
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLA------EVEEKLK-EKSQQLQEKQQQLLNVQEE 1149

Query: 1157 KIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTP 1216
              +  +KI+++E   +K +    E    H+   +L+ A     +Y  + + S+  E    
Sbjct: 1150 MSEMQKKINEIE--NLKNELKNKELTLEHMETERLELAQKLNENY--EEVKSITKERKVL 1205

Query: 1217 ALKCEVNAEDKENSGDYISENE------DPELQDYRYEVQDFQENMHTLLNKVTEEYNKL 1270
                +    ++++   YI E E        EL+     +++ QE +  L   V+E+  ++
Sbjct: 1206 KELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI 1265

Query: 1271 LVLQTRLSKIWGQQTDGMKLEFGEENLP--KEETEFLSIHSQMTNLEDIDVNHKSKLSSL 1328
            +  Q         Q +   L   +E LP  KE +E     +++  L +      S   + 
Sbjct: 1266 INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLAR 1325

Query: 1329 QDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDS 1388
             ++E+ +L E+ QE +  I SL ++    +                    T+  +L V  
Sbjct: 1326 IEMERLRLNEKFQESQEEIKSLTKERDNLK--------------------TIKEALEVKH 1365

Query: 1389 VVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVI 1448
                             +K++I  T+    E   K+E ++         ++ + E  K++
Sbjct: 1366 ---------------DQLKEHIRETLAKIQESQSKQEQSL-------NMKEKDNETTKIV 1403

Query: 1449 VSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK-LSQDQIGFQTFETVD 1507
              M     + + L RI    E    SK+      QE H  +EMK +++++   Q      
Sbjct: 1404 SEMEQFKPKDSALLRIE--IEMLGLSKRL-----QESH--DEMKSVAKEKDDLQ------ 1448

Query: 1508 VKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVR----- 1562
             + +E  +  S +L E+ KEI+  + +  +  +   C L   EE  ++ +  +       
Sbjct: 1449 -RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507

Query: 1563 -------QSIHDEISVSSMDA-SRQLMLNEEQLEDMRQEL--VRQYQEHQQATELLRQAH 1612
                   ++I+D++     +   ++   N +Q+ ++++++  ++Q++EH++A +   Q+ 
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI 1567

Query: 1613 MRQM----ERQREDQEQLQ------EEIKRLNRQLAQRSSIDNEN---LVSERERVLLEE 1659
              +M     R +E QE++Q      EE+KR+   L        EN   +V++ +    +E
Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE 1627

Query: 1660 LEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSN 1719
             + LK  ++   ++  CE+ +   Q +    N   +E +  +  ++  +  +        
Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE-------- 1679

Query: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779
            E  ++ K  + L            +VEET+       ++R    ++    I R   +   
Sbjct: 1680 EMRSVTKERDDL-----------RSVEETLK------VERDQLKENLRETITRDLEKQEE 1722

Query: 1780 KSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPEN 1839
               VH  H +   E+I    G         + S+ T E + + + L  S  A    D + 
Sbjct: 1723 LKIVHM-HLKEHQETIDKLRG---------IVSEKTNEISNMQKDLEHSNDALKAQDLKI 1772

Query: 1840 EELMLNISSRL---QAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
            +E +      L   Q  ++KL   +SE + +L +              QK     + K Q
Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNM-------------QKDLENSNAKLQ 1819

Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
            E++     +E +A E   + L K          E    ++QI++++  + +LE E L  +
Sbjct: 1820 EKI-----QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874

Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
             +L E   E + + +ER+ L R +E +K E   +++  LQET+      LE+Q +     
Sbjct: 1875 QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES-LQETK---ARDLEIQQEL---- 1926

Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR 2076
                K  + L  + +E V +  E   EK  ++ D+++    L+K  ++++K +       
Sbjct: 1927 ----KTARMLSKEHKETVDKLREKISEKTIQISDIQKD---LDKSKDELQKKI------- 1972

Query: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQ 2136
                    QE+QK E QL  V     +S  +  E+EQL    + +      + +   QL 
Sbjct: 1973 --------QELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024

Query: 2137 RDIQERNEEIE---KLEFRVRELEQALLVSADTF------QKVEDRKHFGAVEAKPELSL 2187
            + + E  EEI    K    +R ++++L +  D F          DR++    + KPE  L
Sbjct: 2025 KKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNH---QVKPEKRL 2081

Query: 2188 EVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
                  ++   +   ++ + ++E L+++  E+++  E + +L + LE          +E+
Sbjct: 2082 --LSDGQQHLTESLREKCSRIKELLKRY-SEMDDHYECLNRLSLDLE----------KEI 2128

Query: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ 2307
            E + +L       L L          Q +H+   K     Q   +E  ++   + KL+  
Sbjct: 2129 EFQKELSMRVKANLSLPY-------LQTKHI--EKLFTANQRCSMEFHRI---MKKLKYV 2176

Query: 2308 LKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE--EEIEQLNEVIEKLQQELAN 2365
            L   T  K+ EE++E I   E      M   + V++ +E   +I+ L +  +   +EL +
Sbjct: 2177 LSYVT--KIKEEQHESINKFE------MDFIDEVEKQKELLIKIQHLQQDCDVPSRELRD 2228

Query: 2366 IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ 2425
            +    +M+ H      D  + +   +  E     QQV +  +EMT        T F + +
Sbjct: 2229 LKLNQNMDLHIEEILKDFSESEFPSIKTE----FQQVLSNRKEMTQFLEEWLNTRFDIEK 2284

Query: 2426 LTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT---EDALKSL--ENQ 2480
            L      +++E + + ++ +   N + +AI + S +  E    ++   E  LKSL  +N+
Sbjct: 2285 LKN---GIQKENDRICQVNNFFNNRI-IAIMNESTEFEERSATISKEWEQDLKSLKEKNE 2340

Query: 2481 TYFKSFE----ENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEML 2536
              FK+++        G+ +N  T+  +     S      T+  +++++   + +      
Sbjct: 2341 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK 2400

Query: 2537 QKKIVNLQKIVE--EKVAAALVSQIQ-----LEAVQEYAKFCQDNQTISSEPERTNIQNL 2589
            + KI+ +QK +E    + A L +++      LE  +E  +  QD   + ++P +  I++ 
Sbjct: 2401 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIED- 2459

Query: 2590 NQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKL 2649
                            L++  ++  + +M  +   EKE    A K  +E +K+++   +L
Sbjct: 2460 ----------------LKMKLVKIDLEKMKNAKEFEKE--ISATKATVEYQKEVI---RL 2498

Query: 2650 LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE------SGFFNELEA--LRAESVAT 2701
            L  N ++ ++       QD  V+   T+   SN+       SG     +A  L++E +  
Sbjct: 2499 LRENLRRSQQ------AQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRL 2552

Query: 2702 KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2761
            + E++  K+     Q E L+K+ N   L  +   + + +   KE+    E   +   + S
Sbjct: 2553 EKEISKLKQ-----QNEQLIKQKN--ELLSNNQHLSNEVKTWKERTLKREAHKQVTCENS 2605

Query: 2762 KKA 2764
             K+
Sbjct: 2606 PKS 2608



 Score =  234 bits (596), Expect = 2e-60
 Identities = 465/2359 (19%), Positives = 992/2359 (42%), Gaps = 302/2359 (12%)

Query: 155  THLEMMESELAGKQHEIEEL-----NRELEEM-RVTYGTEGLQQLQEFEAAIKQRDGIIT 208
            T  + ME +   +  E ++L     N ++E + R+   +  L   QE +A  K+R     
Sbjct: 366  TRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR----- 420

Query: 209  QLTANLQQARREKDETMREFLEL----TEQSQKLQIQF-QQLQASETLRNSTHSSTAADL 263
             +T  L +  + K+    +   +    T ++ KL I   +++  S    +   S+T   L
Sbjct: 421  -VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTL 479

Query: 264  LQAKQQILT---HQQQLEEQ--------DHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQ 312
             + +    T   +Q+ +E +        D+L+ DY++ + +       L+EK  + E E 
Sbjct: 480  SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEA 539

Query: 313  DKKVENSNKEEIQEKETIIEELNTK--IIEEEKKTLELKDKLTTADKLLGELQEQIVQ-- 368
               +E   K++ QE + I E  N K  +   E    +L+++L++  +LL E ++QI +  
Sbjct: 540  ---LERKTKKD-QEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQ 595

Query: 369  ---KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425
                +Q+++N+K++L+ S     +S E+ KQ+  T+ + +     D++ E+  ++    E
Sbjct: 596  EYIDSQKLENIKMDLSYS----LESIEDPKQMKQTLFDAE-TVALDAKRESAFLRSENLE 650

Query: 426  TQRKLEQLRAELDEMYGQ-QIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT-- 482
             + K+++L     +M    Q+ Q + E  ++    +E+       E+++A    + +T  
Sbjct: 651  LKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK-------ELQSAFNEITKLTSL 703

Query: 483  ----VNEDQIKLMNV--AINELNIKLQDTNSQKEKLKEELGLILEEKC------ALQRQL 530
                V +D +  + +   I +L  +L     + E L+EE+ L+ E K        L++++
Sbjct: 704  IDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEI 763

Query: 531  EDLVEELSFSREQIQRARQTIAEQESK----LNEAHKSLSTVEDLKAEIVSASESRKELE 586
            +D  EEL     +  +    +  +ES+    L E  K+   +   ++   S  +  +  +
Sbjct: 764  QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFK 823

Query: 587  LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ--EAELERLRTQLLFSHEEELSKLKEDL 644
              H      YK+ LE  E+    +++   E+Q  ++ L  L+T+L +  +E   K +   
Sbjct: 824  TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTR--- 880

Query: 645  EIEHRIN-IEKLKDNLG---------IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694
            E++ R+N +E+LK+ L             K  I     +  ++++T+  EKD+L   Q  
Sbjct: 881  EVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQES 940

Query: 695  LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL 754
            L +E  +LK      VN   +       +L+  +E L+Q ++   TL+ ++ E   +   
Sbjct: 941  LQIERDQLKSDIHDTVNMNIDTQ----EQLRNALESLKQHQETINTLKSKISEEVSRNLH 996

Query: 755  LEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL----DSIK 810
            +E+   E +++ Q+K   ++ +  +     +TL   +K +  + Q+ ++  L    + ++
Sbjct: 997  MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056

Query: 811  SKSKDSVWEKE---------IEILIEENEDL-----------------KQQCIQLNEEIE 844
               +  + EKE         IE+ IE  E+L                 K   I+   E+ 
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116

Query: 845  KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK-QELE-YKSKLKALNEELHL 902
            +  +  +  E+  +   Q+LQE+   LL V++++ + + K  E+E  K++LK  N+EL L
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK--NKELTL 1174

Query: 903  QRINPTTVKMKSSV---FDEDKTFVAETLEMGEV-----------------VEKDTTELM 942
            + +    +++   +   ++E K+   E   + E+                 +E    +  
Sbjct: 1175 EHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTK 1234

Query: 943  EKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIIN 1002
            E+L++      E  + + +L   + +K  +I    +  KS  + +E++ +   E E++ N
Sbjct: 1235 EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN 1294

Query: 1003 HNRAENVQSCDTQVSSLLDGVVT---MTSRGAEGSVSKVNKSF---GEESKIMVEDKVSF 1056
                   Q    ++  L +   T    T    E    ++N+ F    EE K + +++ + 
Sbjct: 1295 VKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354

Query: 1057 ENMTVGEESKQEQL---ILDHLPSVTKESSLR------ATQPSENDKLQKELNVLKSEQN 1107
            + +    E K +QL   I + L  + +  S +        + +E  K+  E+   K + +
Sbjct: 1355 KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDS 1414

Query: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL 1167
             L L++E + + LS       D+++   + + D       +E++ ++ +++KE      +
Sbjct: 1415 AL-LRIEIEMLGLSKRLQESHDEMKSVAKEKDD---LQRLQEVLQSESDQLKE-----NI 1465

Query: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
            +    K  ET +E K  H  + + ++ ++E        L     E  T   + E   +  
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINE----LRVNLSEKETEISTIQKQLEAINDKL 1521

Query: 1228 ENSGDYISENED-------PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKI 1280
            +N    I E E+        E+Q+   E++ F+E+     + +    +K+L L  RL   
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQ-- 1579

Query: 1281 WGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLE--E 1338
              +  + +++   E+   K   E L I          ++  K K S  ++ +  K+    
Sbjct: 1580 --ESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVN 1637

Query: 1339 QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQR 1398
            + QE    I  L++Q +  + N E  I     RL  +    +     V          + 
Sbjct: 1638 ETQEKMCEIEHLKEQFETQKLNLE-NIETENIRLTQILHENLEEMRSVTKERDDLRSVEE 1696

Query: 1399 TM-YPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQ 1457
            T+      +K+N+  TI  + +   +EE  IV +  K++QE +++          I   +
Sbjct: 1697 TLKVERDQLKENLRETI--TRDLEKQEELKIVHMHLKEHQETIDK-------LRGIVSEK 1747

Query: 1458 QTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPL 1517
              E+S +    E++  + +A  +  QE+     M L + Q      ET+D K +      
Sbjct: 1748 TNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ------ETID-KLRGIVSEK 1800

Query: 1518 SKELGEHGKEILLSNS----DPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSS 1573
            + +L    K++  SN+       ++  ++  ++T+ +++    K     + +  +I   S
Sbjct: 1801 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS 1860

Query: 1574 MDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL 1633
            +  S+  + N    + + + L       ++   L R     ++ER     +QL+E ++  
Sbjct: 1861 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER-----DQLKESLQET 1915

Query: 1634 N-RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCE-LRNSSTQ---TQNG 1688
              R L  +  +    ++S+  +  +++L          REK+  + ++ S  Q    ++ 
Sbjct: 1916 KARDLEIQQELKTARMLSKEHKETVDKL----------REKISEKTIQISDIQKDLDKSK 1965

Query: 1689 NENQGEVEEQTFKEKELDRKPEDVPPEILS-NERYALQK----ANNRLLKILLEVVKTTA 1743
            +E Q +++E   KE +L R  EDV       NE   L+K     N  +  + ++  + T 
Sbjct: 1966 DELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTK 2025

Query: 1744 AVEETIGRHVLGILDRSSKSQSSASL-IWRSEAEASVKSCV--HEEHTRVTDESIPSYSG 1800
             + E++    +   +R    +   SL + R +  A+++  +    ++ +V  E      G
Sbjct: 2026 KLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2085

Query: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860
                    ++   + E+ + + + L R     +E+D   E L     +RL   +EK +E 
Sbjct: 2086 QQ------HLTESLREKCSRIKELLKRY----SEMDDHYECL-----NRLSLDLEKEIEF 2130

Query: 1861 ISETSSQLE---HAKVTQTELMRESFRQKQEAT-ESLKCQEELRERLHEESRAREQLAVE 1916
              E S +++        QT+ + + F   Q  + E  +  ++L+  L   ++ +E+    
Sbjct: 2131 QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHES 2190

Query: 1917 LSKAE-GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
            ++K E   ID    +K L  +        I  L+Q+    S  L++L+  Q       E+
Sbjct: 2191 INKFEMDFIDEVEKQKELLIK--------IQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242

Query: 1976 LSRQKEAMKAEAGPVEQQLL---QETEKLMKEKLEVQCQAEKVRDDLQKQ---------- 2022
            L    E+         QQ+L   +E  + ++E L  +   EK+++ +QK+          
Sbjct: 2243 LKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNF 2302

Query: 2023 ----VKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH 2078
                + A+  +  E   R   + +E   +L  L+++N+ L K  + ++  L   A     
Sbjct: 2303 FNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPT 2362

Query: 2079 ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD 2138
             +D     +     QL             T ++ +L N L E  +          ++Q++
Sbjct: 2363 TQDNKNPHVTSRATQL------------TTEKIRELENSLHEAKESAMHKESKIIKMQKE 2410

Query: 2139 IQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAI 2198
            ++  N+ I KL+ +V E  + L  + +T Q ++D+   GA   K E+     L+ +   I
Sbjct: 2411 LEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIE---DLKMKLVKI 2467

Query: 2199 D-RKEKEITNLEEQLEQFREELENKNEEVQQLHMQL-EIQKKESTTRLQELEQENKLFKD 2256
            D  K K     E+++   +  +E + E ++ L   L   Q+ + T+ + E        K 
Sbjct: 2468 DLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKP 2527

Query: 2257 DMEKLGLAI-KESDAMSTQDQHVLFGK-FAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2314
                 G  I + + A+  + +H+   K  +++ Q+ E  I Q NE ++  Q    ++ + 
Sbjct: 2528 LTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQH---LSNEV 2584

Query: 2315 KVIEEKNELIRDLETQIEC 2333
            K  +E+  L R+   Q+ C
Sbjct: 2585 KTWKERT-LKREAHKQVTC 2602



 Score =  216 bits (551), Expect = 3e-55
 Identities = 478/2347 (20%), Positives = 983/2347 (41%), Gaps = 365/2347 (15%)

Query: 276  QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK--ETIIEE 333
            ++   + LL+ Y+K+  D   Q+  +  + +   ME+D+  +   ++++ +K     IE 
Sbjct: 337  EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396

Query: 334  LNTKIIEEEKKTLELKDKLTTADKL---LGELQEQ---------IVQKNQEIKNMKLELT 381
            L   ++     TL+ + K     ++   LG++ +           +  N   K  KL + 
Sbjct: 397  LTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSIN 456

Query: 382  NSKQKERQSSEEIKQLMGTVEELQK---------RNHKDSQFETDIVQRMEQETQRKLEQ 432
              ++ +     E      T++ L +          N ++ + E + ++          EQ
Sbjct: 457  LLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQ 516

Query: 433  LRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMN 492
            LR E +EM     +++K++        +E  KT+   EM+  +   SN+       ++ N
Sbjct: 517  LRTEKEEME----LKLKEKNDLDEFEALER-KTKKDQEMQ-LIHEISNLKNLVKHAEVYN 570

Query: 493  VAI-NELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQ---RAR 548
              + NEL+ K++    +++++K+     L+E    Q+ LE++  +LS+S E I+   + +
Sbjct: 571  QDLENELSSKVELLREKEDQIKK-----LQEYIDSQK-LENIKMDLSYSLESIEDPKQMK 624

Query: 549  QTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN 608
            QT+ + E+   +A +  +    L++E +   E  KEL   ++    + ++    LE +K 
Sbjct: 625  QTLFDAETVALDAKRESAF---LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK 681

Query: 609  AVLDRMAESQEA--ELERLRT--------QLLFSHEEE--LSKLKEDLEIEHRINIEKLK 656
              +D   E Q A  E+ +L +         LL + E E  ++ L+++L  E   N E L+
Sbjct: 682  MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN-EALR 740

Query: 657  DNLGI-----HYKQQIDGLQNEMSQKIETMQF---EKDNLI-------TKQNQLILEISK 701
            + + +         +++ L+ E+  K E +     EKD L        ++   L+ EI K
Sbjct: 741  EEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800

Query: 702  LK-DLQQSLVNSKSEEM------TLQINELQKEIEILRQEEK---EKGTLEQEVQELQ-- 749
             K DL  +  N KS +       TL ++  QK   +L + E+   E   L +E Q+    
Sbjct: 801  TKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860

Query: 750  ---LKTELLEK--QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVS------ 798
               LKTEL  K  +++EK  ++QE+  ++E     L++   TL+ + +  T ++      
Sbjct: 861  LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQT 920

Query: 799  -----------------QEERLIFLDSIKSKSKDSV-----WEKEIEILIEENEDLKQQC 836
                             QE   I  D +KS   D+V      ++++   +E  +  ++  
Sbjct: 921  LEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI 980

Query: 837  IQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLE---------DSKNKQEL 887
              L  +I ++ +     E+N      E Q++   + K K DLE         D K+ + +
Sbjct: 981  NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDK-KQDLEAKNTQTLTADVKDNEII 1039

Query: 888  EYKSKLKAL-NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
            E + K+ +L  E+  LQ++  + +  K  +  + K  +  T+E  E +     EL ++ E
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099

Query: 947  VTKREKL-------ELSQ---RLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRE 996
            +  +EK        ELS+   RL+++ E+LK+K  ++    +++ ++++E  ++  +  E
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159

Query: 997  LEIIINH--NRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV 1054
            +E + N   N+   ++  +T+   L        ++    +  +V KS  +E K++ E + 
Sbjct: 1160 IENLKNELKNKELTLEHMETERLEL--------AQKLNENYEEV-KSITKERKVLKELQK 1210

Query: 1055 SFEN------------MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVL 1102
            SFE                G ++K E+L + H+     + ++   + S ++K  + +N  
Sbjct: 1211 SFETERDHLRGYIREIEATGLQTK-EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269

Query: 1103 KSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQ 1162
              E++  +LQ E   +        +V +V E  E        ++ E  +  ++   K+  
Sbjct: 1270 DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQE--------TMNELELLTEQSTTKDST 1321

Query: 1163 KIHQLELQTM----KTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218
             + ++E++ +    K QE+ +E K L      L K + E     L+     L E+    L
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTKERDNL-KTIKEA----LEVKHDQLKEHIRETL 1376

Query: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLS 1278
                 ++ K+     + E +D E      E++ F+     LL        ++ +    LS
Sbjct: 1377 AKIQESQSKQEQSLNMKE-KDNETTKIVSEMEQFKPKDSALL--------RIEIEMLGLS 1427

Query: 1279 KIWGQQTDGMKLEFGEENLPKEETEFLSIHSQM--TNLEDIDVNHKSKLSSLQDLEKTKL 1336
            K   +  D MK    E++  +   E L   S     N+++I   H      L+  E+ K+
Sbjct: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH------LETEEELKV 1481

Query: 1337 EE-QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESD 1395
                ++E E  I+ L+  L E     E EI  +QK+L+A+++      L      I E +
Sbjct: 1482 AHCCLKEQEETINELRVNLSEK----ETEISTIQKQLEAIND-----KLQNKIQEIYEKE 1532

Query: 1396 AQRTMYPGSCVKKNIDGTIEFSGEFGVKE---ETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452
             Q  +   S V++ ++   +F      K+   ++   K+LE   + Q  +E  ++++   
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIK-- 1590

Query: 1453 IAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKE 1512
                ++ E+ R+                          +++ +DQ+   T E V  K KE
Sbjct: 1591 ----EKEEMKRVQ-----------------------EALQIERDQLKENTKEIV-AKMKE 1622

Query: 1513 EFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVS 1572
                 S+E     KE         +  + K C +   +E F   K  +      + I   
Sbjct: 1623 -----SQE-----KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL------ENIETE 1666

Query: 1573 SMDASRQLMLNEEQL-------EDMRQELVRQYQEHQQATELLRQAHMRQMERQRE---- 1621
            ++  ++ L  N E++       +D+R        E  Q  E LR+   R +E+Q E    
Sbjct: 1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIV 1726

Query: 1622 --DQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
                ++ QE I +L   +++++     N +S  ++ L    +ALK   L  +E+L     
Sbjct: 1727 HMHLKEHQETIDKLRGIVSEKT-----NEISNMQKDLEHSNDALKAQDLKIQEELRIAHM 1781

Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN-NRLLKILLEV 1738
            +   Q +  ++ +G V E+T K   + +  E+   ++   E+    KAN ++L+ +  +V
Sbjct: 1782 HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL--QEKIQELKANEHQLITLKKDV 1839

Query: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
             +T   V E      +  L +  K QS    +  S+ E    +   + H     E++   
Sbjct: 1840 NETQKKVSE------MEQLKKQIKDQS----LTLSKLEIENLNLAQKLH-----ENLEEM 1884

Query: 1799 SGSDMPRNDINMWSKVTE-EGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL 1857
                  R+++    +  + E  +L + L  +     EI  E +   + +S   +  V+KL
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM-LSKEHKETVDKL 1943

Query: 1858 LEAISETSSQLEHAK----VTQTELMRESFRQKQEATESLKCQEEL---RERLHEESRAR 1910
             E ISE + Q+   +     ++ EL ++    +++  + L+ +E++    ++++E  + +
Sbjct: 1944 REKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLK 2003

Query: 1911 EQL-AVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQE-LEAEQQQ 1968
            +Q  A  LS     +D +   K L E    E+  I+ +   EL     R++E L+ E+ Q
Sbjct: 2004 KQFEAQNLSMQSVRMDNFQLTKKLHES--LEEIRIVAKERDEL----RRIKESLKMERDQ 2057

Query: 1969 -IQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK-------VRDDLQ 2020
             I   RE+++R ++  + +    E++LL + ++ + E L  +C   K         DD  
Sbjct: 2058 FIATLREMIARDRQNHQVKP---EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY 2114

Query: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER 2080
            + +  L +D+E+++    EL       L     Q + +EK       F   Q    E   
Sbjct: 2115 ECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEK------LFTANQRCSME--- 2165

Query: 2081 DVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQ 2140
              F + ++KL+  L  V +   I E Q   + +      ++ +K  ELL+  + LQ+D  
Sbjct: 2166 --FHRIMKKLKYVLSYVTK---IKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDC- 2219

Query: 2141 ERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDR 2200
                ++   E R  +L Q + +  +   K      F +++ + +     Q+ + R  + +
Sbjct: 2220 ----DVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQ-----QVLSNRKEMTQ 2270

Query: 2201 KEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEK 2260
              +E  N    +E+ +  ++ +N+ + Q++     +         E E+ +     + E+
Sbjct: 2271 FLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQ 2330

Query: 2261 LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEK 2320
               ++KE +    ++   L    A   Q      D  N  VT    QL   T  K+ E +
Sbjct: 2331 DLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQL---TTEKIRELE 2387

Query: 2321 NELIRDLETQIECLMSDQECVKRNREEE------------IEQLNEVIEKLQQELANIGQ 2368
            N L    E +   +  + + +K  +E E            + + N+ +EK ++ +  +  
Sbjct: 2388 NSL---HEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQD 2444

Query: 2369 KTSMNAHSLSEEADSLKHQLDVVIAEKL----ALEQQVETANEEMTFMKNVLK--ETNFK 2422
            K ++ A    EE + LK +L  +  EK+      E+++      + + K V++    N +
Sbjct: 2445 KVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLR 2504

Query: 2423 MNQLTQE 2429
             +Q  Q+
Sbjct: 2505 RSQQAQD 2511



 Score =  207 bits (527), Expect = 2e-52
 Identities = 401/1996 (20%), Positives = 835/1996 (41%), Gaps = 281/1996 (14%)

Query: 1717 LSNERYALQKANNRLLKILLEVVKTTAAV------EETIGRHVLGILDRSSKSQSSASLI 1770
            L  E+  LQK  N  ++ L  ++ T++++      +    R V   L + +K ++S +  
Sbjct: 379  LLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNS-NYA 437

Query: 1771 WRSEAEASVKSCVHE---EHTRVTDESIPSYSGSDMPRNDINMWSKV---------TEEG 1818
             +     ++ +  H+      R  DES+   S SD+  N ++  S++          +E 
Sbjct: 438  DQFNIPTNITTKTHKLSINLLREIDESV--CSESDVFSNTLDTLSEIEWNPATKLLNQEN 495

Query: 1819 TELSQRLVRSGFAGTEID-----PENEELMLNISSR--------LQAAVEK-----LLEA 1860
             E     +R+ +    +D      E EE+ L +  +        L+   +K     L+  
Sbjct: 496  IESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHE 555

Query: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHE--ESRAREQLAVELS 1918
            IS   + ++HA+V   +L  E         E L+ +E+  ++L E  +S+  E + ++LS
Sbjct: 556  ISNLKNLVKHAEVYNQDLENEL----SSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS 611

Query: 1919 KA-EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLS 1977
             + E + D    ++TLF+             E   L A      L +E  +++E+ + L+
Sbjct: 612  YSLESIEDPKQMKQTLFDA------------ETVALDAKRESAFLRSENLELKEKMKELA 659

Query: 1978 RQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF 2037
               + M+ +    + QL  E +K M+  LE + Q+    +++ K    ++  V + +   
Sbjct: 660  TTYKQMENDIQLYQSQL--EAKKKMQVDLEKELQS--AFNEITKLTSLIDGKVPKDLLCN 715

Query: 2038 IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVV 2097
            +ELE +    + DL+++   L K++E               E +  ++E+  L + LK +
Sbjct: 716  LELEGK----ITDLQKE---LNKEVE---------------ENEALREEVILLSE-LKSL 752

Query: 2098 PRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE 2157
            P           EVE+L   +++K+++   +   K++L  ++  +   ++ L   + + +
Sbjct: 753  PS----------EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK 802

Query: 2158 QALLVSADTFQKVEDR-KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFR 2216
              L  +   ++  +   ++F  +    E   ++ L+      +R  +EI NL ++ ++F 
Sbjct: 803  DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN----ERMNQEIVNLSKEAQKFD 858

Query: 2217 EELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQ 2276
              L     E+     +L+ + +E   RL E+EQ     K+ +E      ++S   + + +
Sbjct: 859  SSLGALKTELSYKTQELQEKTREVQERLNEMEQ----LKEQLEN-----RDSTLQTVERE 909

Query: 2277 HVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMS 2336
              L  +  Q   E+   + Q  + + +LQ+ L+I        E+++L  D+   +   + 
Sbjct: 910  KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQI--------ERDQLKSDIHDTVNMNID 961

Query: 2337 DQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH---SLSEEADSLKHQLDVVIA 2393
             QE + RN  E ++Q  E I  L+ +   I ++ S N H   +  E  D  + ++ V I 
Sbjct: 962  TQEQL-RNALESLKQHQETINTLKSK---ISEEVSRNLHMEENTGETKDEFQQKM-VGID 1016

Query: 2394 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNV 2453
            +K  LE +  T         N + E   K+  L QE   L++  ESV   +   +  +  
Sbjct: 1017 KKQDLEAK-NTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075

Query: 2454 AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDL 2513
             I+   +++ EL + L ++  K  E     K+     +G +     RL ++E  +  K  
Sbjct: 1076 NIEMTIENQEELRL-LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1134

Query: 2514 ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEE----KVAAALVSQIQLEAVQEYAK 2569
            +L +  +Q+ ++QE    E   +QKKI  ++ +  E    ++    +   +LE  Q+  +
Sbjct: 1135 QLQEKQQQLLNVQE----EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNE 1190

Query: 2570 FCQDNQTISSEPE-RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQ 2628
              ++ ++I+ E +    +Q   +   D L   I  +     + + ++   H  L   +E 
Sbjct: 1191 NYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQET 1250

Query: 2629 VEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFF 2688
            ++   ++V EK  +++  Q L + + K Q E       Q  E+L    E+  + E     
Sbjct: 1251 IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQ--ELLPNVKEVSETQET---M 1305

Query: 2689 NELEALRAESVATKAE-LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL 2747
            NELE L  +S    +  LA  + +  +L E+    +  + SL K+    RD+L   KE L
Sbjct: 1306 NELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE----RDNLKTIKEAL 1361

Query: 2748 SILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQT--------PQILV 2799
             +   + +  ++E+           + S ++  + + T KI S  +          +I +
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI 1421

Query: 2800 KNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAE-------ILDMESRHISETET 2852
            +  G+   LQ    S +  + +++  + ++++QE+  +E       I ++ ++H+   E 
Sbjct: 1422 EMLGLSKRLQE---SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478

Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
            LK  H      LKE+  T+  +   L  KE             Q +    +D   +  Q 
Sbjct: 1479 LKVAHCC----LKEQEETINELRVNLSEKE-------TEISTIQKQLEAINDKLQNKIQE 1527

Query: 2913 IYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHS 2972
            IY    Q F+I      +E  +    F +  K    A+ +   ++L LT       E+  
Sbjct: 1528 IYEKEEQ-FNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586

Query: 2973 IQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQ 3032
            I    +   EE K     +   +D + +   +  A++ +S +    F             
Sbjct: 1587 IMIKEK---EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQF------------- 1630

Query: 3033 VFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS 3092
                           ++TA+  T       C  + ++EQ    +  +E ++  + R    
Sbjct: 1631 --------------LKMTAVNETQEK---MCEIEHLKEQFETQKLNLENIETENIRLT-- 1671

Query: 3093 EIQALHAQMNG-RKITLKRE-----QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDR 3146
              Q LH  +   R +T +R+     +E+ K  ++ L+ N+++  ++ LE Q EL  +   
Sbjct: 1672 --QILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH 1729

Query: 3147 ATELQEQLSSEKMVVAELKSELAQTKLELETT---LKAQH-KHLKELEAFRLEVKDKTDE 3202
              E QE +   + +V+E  +E++  + +LE +   LKAQ  K  +EL    + +K++ + 
Sbjct: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789

Query: 3203 VHLLNDTLASEQKKSRELQWALEKEKAKLGRSEER---DKEELEDLKFSLESQKQRNLQL 3259
            +  L   ++ +  K   +Q  LE   AKL    +    ++ +L  LK  +   +++  ++
Sbjct: 1790 IDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849

Query: 3260 NLLLEQQK-QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3318
              L +Q K Q L  S+ +IE+        L+++   NLE    +  E+  +R +  TL  
Sbjct: 1850 EQLKKQIKDQSLTLSKLEIEN------LNLAQKLHENLEEMKSVMKERDNLRRVEETLKL 1903

Query: 3319 ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQ 3378
            ER+                         +L++ L+E  +R +E+  E +  ++ S + ++
Sbjct: 1904 ERD-------------------------QLKESLQETKARDLEIQQELKTARMLSKEHKE 1938

Query: 3379 QMEKDRQ-VHRKTLQTEQ------EANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431
             ++K R+ +  KT+Q         ++  E QKK+ ELQ K   L R  E+      K++ 
Sbjct: 1939 TVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKIN- 1997

Query: 3432 EGQRLQGIMQEFQKQELEREEKR----ESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE 3487
                ++ + ++F+ Q L  +  R    +  + L+++L E    +   D  R      K+E
Sbjct: 1998 ---EMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME 2054

Query: 3488 GETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDF 3547
             +   +   ++I  +        E  ++    Q +   L+    +  E L+  +  D+ +
Sbjct: 2055 RDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY 2114

Query: 3548 IWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSL----TERLLRQNAELTGHISQLT 3603
                E ++ + L L+K    Q E    V  + S   L     E+L   N   +    ++ 
Sbjct: 2115 ----ECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIM 2170

Query: 3604 EEKNDLRNMVMKLEEQ 3619
            ++   + + V K++E+
Sbjct: 2171 KKLKYVLSYVTKIKEE 2186



 Score =  197 bits (502), Expect = 1e-49
 Identities = 498/2516 (19%), Positives = 1031/2516 (40%), Gaps = 394/2516 (15%)

Query: 1052 DKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRL 1111
            ++VS +   +    K+   +   L  V+ E+  +A +  +  +L +E ++L+  QN+   
Sbjct: 336  NEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNE--- 392

Query: 1112 QMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQT 1171
              + + +   LV S+ +   +E     K +    L          KI +++  +  +   
Sbjct: 393  --KIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLG---------KINKMKNSNYADQFN 441

Query: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSG 1231
            + T  T    K    L+ ++ ++V  E   F  TL ++    + PA K  +N        
Sbjct: 442  IPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKL-LN-------- 492

Query: 1232 DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLE 1291
                                 QEN+ + LN +  +Y+ L++   +L      + + M+L+
Sbjct: 493  ---------------------QENIESELNSLRADYDNLVLDYEQLRT----EKEEMELK 527

Query: 1292 FGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQ 1351
              E+N   +  EF ++  +    +++ + H+  +S+L++L K   E   Q+LE+ +SS  
Sbjct: 528  LKEKN---DLDEFEALERKTKKDQEMQLIHE--ISNLKNLVK-HAEVYNQDLENELSSKV 581

Query: 1352 QQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITES-----DAQRTMYPGSCV 1406
            + L+E E           K+LQ   +S    ++ +D     ES       ++T++    V
Sbjct: 582  ELLREKEDQI--------KKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETV 633

Query: 1407 KKNIDGTIEF--SGEFGVKEETNIVKLLEKQ-------YQEQLEEEVAKVI---VSMSIA 1454
              +      F  S    +KE+   +    KQ       YQ QLE +    +     +  A
Sbjct: 634  ALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSA 693

Query: 1455 FAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF 1514
            F + T+L+ +  GK      K      + E    +  K    ++        +V    E 
Sbjct: 694  FNEITKLTSLIDGKV----PKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSEL 749

Query: 1515 KPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSM 1574
            K L  E+    KEI   + + H I   KD + +   E+  K+      Q + +EI  +  
Sbjct: 750  KSLPSEVERLRKEIQDKSEELHIITSEKDKLFS---EVVHKESRV---QGLLEEIGKTKD 803

Query: 1575 DASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLN 1634
            D +     N +  +   Q     + + +Q  +++    + + ER  ++   L +E ++ +
Sbjct: 804  DLATT-QSNYKSTDQEFQNFKTLHMDFEQKYKMV----LEENERMNQEIVNLSKEAQKFD 858

Query: 1635 RQL-AQRSSIDNENL-VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQ 1692
              L A ++ +  +   + E+ R + E L  ++QL    +E+L  E R+S+ QT       
Sbjct: 859  SSLGALKTELSYKTQELQEKTREVQERLNEMEQL----KEQL--ENRDSTLQTVE----- 907

Query: 1693 GEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRH 1752
                E+T   ++L +  E+V  + L+ E+  L++    L    +E  +  + + +T+   
Sbjct: 908  ---REKTLITEKLQQTLEEV--KTLTQEKDDLKQLQESLQ---IERDQLKSDIHDTVN-- 957

Query: 1753 VLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWS 1812
             + I  +     +  SL    E   ++KS + EE +R                 +++M  
Sbjct: 958  -MNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR-----------------NLHMEE 999

Query: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELML-----NISSRLQAAVEKLLEAISETSSQ 1867
               E   E  Q++V       +++ +N + +      N     Q  +  L++  +E    
Sbjct: 1000 NTGETKDEFQQKMVGID-KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM 1058

Query: 1868 LEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS---KAEGVI 1924
            LE   + + E ++   ++  E T  ++ QEELR    E  + +E +A E +   K EG +
Sbjct: 1059 LESV-IAEKEQLKTDLKENIEMT--IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGEL 1115

Query: 1925 DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK---E 1981
                D     E +++EK+  +   +Q+LL     + E++ +  +I+  +  L  ++   E
Sbjct: 1116 SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE 1175

Query: 1982 AMKAEAGPVEQQL---LQETEKLMKEKL---EVQCQAEKVRDDLQ---KQVKALEIDVEE 2032
             M+ E   + Q+L    +E + + KE+    E+Q   E  RD L+   ++++A  +  +E
Sbjct: 1176 HMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE 1235

Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092
            ++ +   +  +++ E +D  +++ +     EK  + ++ Q +++ H +   Q+EI  L +
Sbjct: 1236 EL-KIAHIHLKEHQETIDELRRSVS-----EKTAQIINTQDLEKSHTK--LQEEIPVLHE 1287

Query: 2093 QLKVVPRFQPISEHQT--REVEQLANHLKEK-TDKCSELLLSKEQLQRDIQERNEEIEKL 2149
            + +++P  + +SE Q    E+E L      K +   + + + + +L    QE  EEI+ L
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347

Query: 2150 ---EFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206
                  ++ +++AL V  D       ++H     AK + S   Q Q+    +  K+ E T
Sbjct: 1348 TKERDNLKTIKEALEVKHDQL-----KEHIRETLAKIQESQSKQEQSLN--MKEKDNETT 1400

Query: 2207 NLEEQLEQFRE----------ELENKNEEVQQLHMQLE--IQKKESTTRLQE-LEQENKL 2253
             +  ++EQF+           E+   ++ +Q+ H +++   ++K+   RLQE L+ E+  
Sbjct: 1401 KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQ 1460

Query: 2254 FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD 2313
             K++++++     E++    +  H    +  + I E  V + +   +++ +Q+QL+   D
Sbjct: 1461 LKENIKEIVAKHLETEE-ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIND 1519

Query: 2314 ---NKVIE--EKNELIRDLE-TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2367
               NK+ E  EK E     + ++++  +++ +  K +R+ +   L  +  K+  EL N  
Sbjct: 1520 KLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKML-ELTNRL 1578

Query: 2368 QKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQV--------ETANEEMTFMK-NVLKE 2418
            Q++      + +E + +K   + +  E+  L++          E+  +E  F+K   + E
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638

Query: 2419 TNFKMNQL--------TQELFSLKRERESVEKIQSIPEN-----SVNVAIDHLSKDKPEL 2465
            T  KM ++        TQ+L     E E++   Q + EN     SV    D L   +  L
Sbjct: 1639 TQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETL 1698

Query: 2466 EVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQ-----LESTVSAKDLELTQCYK 2520
            +V    D LK    +T  +  E+  +  I+++  +  Q     L   VS K  E++   K
Sbjct: 1699 KV--ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQK 1756

Query: 2521 QIKDMQEQGQFETEMLQKKI-VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISS 2579
             ++   +  + +   +Q+++ +    + E++     +  I  E   + +   +D +  ++
Sbjct: 1757 DLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNA 1816

Query: 2580 EPERTNIQNL--NQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL 2637
            + +   IQ L  N+ +   L  D++    ++SE+E Q+ +      L   ++EI   N+ 
Sbjct: 1817 KLQE-KIQELKANEHQLITLKKDVNETQKKVSEME-QLKKQIKDQSLTLSKLEIENLNLA 1874

Query: 2638 EKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2697
            +K  + LE        E K   KE+    +  E LK   +    + +     +LE ++ E
Sbjct: 1875 QKLHENLE--------EMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLE-IQQE 1925

Query: 2698 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2757
                +     +KE  +KL+E++  K   ++ +QKDL + +D L              + +
Sbjct: 1926 LKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDEL--------------QKK 1971

Query: 2758 VQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEV 2817
            +QE +K         K  + +  + D  +     N+  Q+  +     +++QS      V
Sbjct: 1972 IQELQK---------KELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQS------V 2016

Query: 2818 TEIISQFTEKI-EKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQ 2876
                 Q T+K+ E ++E+        E R I E+  ++R+ ++A         TL+ +I 
Sbjct: 2017 RMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIA---------TLREMIA 2067

Query: 2877 CLRSKEGSSIPELAHSDAYQ-----TREICSSDSG-----SDWGQGIYLTHSQGFDIASE 2926
              R        +   SD  Q      RE CS         S+        +    D+  E
Sbjct: 2068 RDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE 2127

Query: 2927 GRGEESES----ATDSFP----KKIKGLLRAVHNEGMQ----------VLSLTESPYSDG 2968
               ++  S    A  S P    K I+ L  A     M+          VLS   +   + 
Sbjct: 2128 IEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYV-TKIKEE 2186

Query: 2969 EDHSIQQVSEPWLEERKAYINTISSLKDLITKMQ-LQREAEVYDSSQSHESFSDWRGELL 3027
            +  SI +    +++E       +   K+L+ K+Q LQ++ +V          +     + 
Sbjct: 2187 QHESINKFEMDFIDE-------VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQ---NMD 2236

Query: 3028 LALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQ--------EQGVEYQAAM 3079
            L ++++  +       + +TE   +  ++   +   LE+ +         + G++ +   
Sbjct: 2237 LHIEEILKDFSESEFPSIKTEFQQV-LSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDR 2295

Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESE----KPSQELLEYNIQQKQSQMLE 3135
             C       + +  I     +   R  T+ +E E +    K   E L  N Q  ++ +  
Sbjct: 2296 ICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLAS 2355

Query: 3136 -MQVELSSMKDR---ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEA 3191
              QV  ++  ++    T    QL++EK  + EL++ L + K        A HK  K ++ 
Sbjct: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEK--IRELENSLHEAKES------AMHKESKIIKM 2407

Query: 3192 FRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA-------KLGRSEERDKEELED 3244
             +        E+ + ND +A  Q K  E    LEK K        K+    +  KEE+ED
Sbjct: 2408 QK--------ELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIED 2459

Query: 3245 LKFSL---ESQKQRNLQ--------LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEE-- 3291
            LK  L   + +K +N +            +E QK+++   ++ +   +   D  +  E  
Sbjct: 2460 LKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHT 2519

Query: 3292 --QGRNLEL-------------QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSR 3336
              Q  N  L              ++L+SE +R+ +  S L ++ E   QL        S 
Sbjct: 2520 DPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNE---QLIKQKNELLSN 2576

Query: 3337 PPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQ 3392
                S ++    ++ L+ +  + V   N  +  K+    ++++     Q   + LQ
Sbjct: 2577 NQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQ 2632



 Score =  195 bits (496), Expect = 6e-49
 Identities = 473/2407 (19%), Positives = 984/2407 (40%), Gaps = 402/2407 (16%)

Query: 1431 LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNE 1490
            LL+K   E++E     ++ S S+   Q+ +  R           K+    C  +    N+
Sbjct: 385  LLQKVQNEKIENLTRMLVTSSSLTLQQELKAKR-----------KRRVTWCLGK---INK 430

Query: 1491 MKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE 1550
            MK S     F     +  K  +    L +E+ E     + S SD        + + T+SE
Sbjct: 431  MKNSNYADQFNIPTNITTKTHKLSINLLREIDES----VCSESDVFS-----NTLDTLSE 481

Query: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610
              ++     + +++I  E++    D    L+L+ EQL   ++E+  + +E     E    
Sbjct: 482  IEWNPATKLLNQENIESELNSLRADYDN-LVLDYEQLRTEKEEMELKLKEKNDLDEF--- 537

Query: 1611 AHMRQMERQ-REDQE-QLQEEIKRLNRQL--AQRSSIDNENLVSERERVLLEELEALKQL 1666
                 +ER+ ++DQE QL  EI  L   +  A+  + D EN +S +  +L E+ + +K+L
Sbjct: 538  ---EALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKL 594

Query: 1667 SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKE--LDRKPEDVPPEILSNERYAL 1724
                  +    ++   + +    E+  ++++  F  +   LD K E             L
Sbjct: 595  QEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESA----------FL 644

Query: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784
            +  N  L + + E+  T   +E  I  +         +SQ  A    + + E  ++S  +
Sbjct: 645  RSENLELKEKMKELATTYKQMENDIQLY---------QSQLEAKKKMQVDLEKELQSAFN 695

Query: 1785 E--EHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL 1842
            E  + T + D  +P     D+  N + +  K+T+   EL++ +  +     E+      +
Sbjct: 696  EITKLTSLIDGKVPK----DLLCN-LELEGKITDLQKELNKEVEENEALREEV------I 744

Query: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRER 1902
            +L+    L + VE+L + I + S +L H   ++ + +      K+   + L         
Sbjct: 745  LLSELKSLPSEVERLRKEIQDKSEEL-HIITSEKDKLFSEVVHKESRVQGL--------- 794

Query: 1903 LHEESRAREQLAVELSKAEGVIDGYADEKTL---FERQIQEKTDIIDRLEQELLCASN-- 1957
            L E  + ++ LA   S  +     + + KTL   FE++ +   +  +R+ QE++  S   
Sbjct: 795  LEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854

Query: 1958 ----------------RLQELEAEQQQIQE---ERELLSRQKEAMKAEAGPVEQQLLQET 1998
                            + QEL+ + +++QE   E E L  Q E   +    VE++    T
Sbjct: 855  QKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT 914

Query: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEI-------DVEEQVSRFIELEQEKNTELMDL 2051
            EKL +   EV+   ++ +DDL++  ++L+I       D+ + V+  I+ +++    L  L
Sbjct: 915  EKLQQTLEEVKTLTQE-KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973

Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHE---RDVFQQEI------QKLE----QQLKVVP 2098
            +Q  + +     K+ + +       E+    +D FQQ++      Q LE    Q L    
Sbjct: 974  KQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADV 1033

Query: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
            +   I E Q R++  L     E       ++  KEQL+ D++E  E   + +  +R L  
Sbjct: 1034 KDNEIIEQQ-RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGD 1092

Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELS--------LEVQLQAERDAIDRKEKEITNLEE 2210
             L    +     +++ H  A++ + ELS        +E +L+ +   +  K++++ N++E
Sbjct: 1093 ELKKQQEIV--AQEKNH--AIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQE 1148

Query: 2211 QLEQFRE---ELEN-----KNEEVQQLHMQ---LEIQKK--ESTTRLQELEQENKLFKD- 2256
            ++ + ++   E+EN     KN+E+   HM+   LE+ +K  E+   ++ + +E K+ K+ 
Sbjct: 1149 EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL 1208

Query: 2257 ----------------DMEKLGLAIKES---------DAMSTQDQ--HVLFGKFAQIIQE 2289
                            ++E  GL  KE          +   T D+    +  K AQII  
Sbjct: 1209 QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINT 1268

Query: 2290 KEVEID--QLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREE 2347
            +++E    +L E++  L ++ ++  + K + E  E + +LE   E   +         E 
Sbjct: 1269 QDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEM 1328

Query: 2348 EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE 2407
            E  +LNE  ++ Q+E+ ++ ++   N  ++ E  +    QL   I E LA  Q+ ++  E
Sbjct: 1329 ERLRLNEKFQESQEEIKSLTKERD-NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387

Query: 2408 EMTFMKNVLKETNFKMNQLTQ-------------ELFSL-KRERESVEKIQSIPENSVNV 2453
            +   MK    ET   ++++ Q             E+  L KR +ES ++++S+ +   ++
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447

Query: 2454 AI--DHLSKDKPELEVVLTEDALKSLENQTYFK-------SFEENGKGSIINL---ETRL 2501
                + L  +  +L+  + E   K LE +   K         EE      +NL   ET +
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507

Query: 2502 LQLESTVSAKDLELTQCYKQIKDMQEQGQF-ETEMLQKKIVNLQKIVEEKVAAALVSQIQ 2560
              ++  + A + +L    ++I + +EQ    +   +Q+K+  L++  E + A     Q  
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI 1567

Query: 2561 LEAVQEYAKFCQDNQT-----ISSEPERTNIQNLNQLREDELGSDISALTLRISELE--- 2612
               + E     Q++Q      I  + E   +Q   Q+  D+L  +   +  ++ E +   
Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE 1627

Query: 2613 ---------SQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKK 2663
                     ++  E    +   KEQ E  + N+   E + + L ++L  N ++ R   K+
Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKE 1687

Query: 2664 RSP--QDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2721
            R       E LK   +    N       +LE  + E       L  ++E  +KL+  +  
Sbjct: 1688 RDDLRSVEETLKVERDQLKENLRETITRDLEK-QEELKIVHMHLKEHQETIDKLRGIVSE 1746

Query: 2722 KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQ 2781
            K   ++++QKDL    D L     K   L+ ++E  +         E +  KL   ++ +
Sbjct: 1747 KTNEISNMQKDLEHSNDAL-----KAQDLKIQEELRIAHMHLKEQQETID-KLRGIVSEK 1800

Query: 2782 TDGTLKISSSNQTPQILVKNAGIQINLQSECSSEE----VTEIISQFTEKIEKMQELHAA 2837
            TD       SN    +   NA +Q  +Q   ++E     + + +++  +K+ +M++L   
Sbjct: 1801 TD-----KLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK- 1854

Query: 2838 EILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT 2897
            +I D +S  +S+ E    E+    Q L E    +K+V+     KE  ++  +  +   + 
Sbjct: 1855 QIKD-QSLTLSKLEI---ENLNLAQKLHENLEEMKSVM-----KERDNLRRVEETLKLER 1905

Query: 2898 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV 2957
             ++  S           L  ++  D+  +   + +   +    + +  L   +  + +Q+
Sbjct: 1906 DQLKES-----------LQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQI 1954

Query: 2958 LSLTES--PYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQS 3015
              + +      D     IQ++ +  L+  +   +   S K +    QL+++ E  + S  
Sbjct: 1955 SDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ 2014

Query: 3016 HESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEY 3075
                 ++  +L   L +   E R  ++A  R EL                +RI+E     
Sbjct: 2015 SVRMDNF--QLTKKLHESLEEIR--IVAKERDEL----------------RRIKES---- 2050

Query: 3076 QAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLE 3135
                    K +R   ++ ++ + A+ + +   +K E+      Q+ L  ++++K S++ E
Sbjct: 2051 -------LKMERDQFIATLREMIAR-DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE 2102

Query: 3136 MQVELSSMKDR-------ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3188
            +    S M D        + +L++++  +K +   +K+ L+   L        Q KH+++
Sbjct: 2103 LLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYL--------QTKHIEK 2154

Query: 3189 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDL-KF 3247
            L                      + Q+ S E    ++K K  L    +  +E+ E + KF
Sbjct: 2155 L--------------------FTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF 2194

Query: 3248 SLESQKQRNLQLNLLLEQQKQLLNESQQKIES----QRMLYDAQLSEEQGRNLE--LQVL 3301
             ++   +        +E+QK+LL + Q   +      R L D +L++    ++E  L+  
Sbjct: 2195 EMDFIDE--------VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDF 2246

Query: 3302 LESEKVRIR-EMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK----- 3355
             ESE   I+ E    L   +E+   L+    T         E L   +QK+ +       
Sbjct: 2247 SESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTR-----FDIEKLKNGIQKENDRICQVNN 2301

Query: 3356 --HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVE 3413
              ++RI+ ++NE+ +++  S    ++ E+D       L++ +E N +  K    L++ + 
Sbjct: 2302 FFNNRIIAIMNESTEFEERSATISKEWEQD-------LKSLKEKNEKLFKNYQTLKTSLA 2354

Query: 3414 DLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRES-----RRILYQNLNEPT 3468
                Q+    Q      +  +  Q   ++ ++ E    E +ES      +I+        
Sbjct: 2355 S-GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEV 2413

Query: 3469 TWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQV 3528
            T  + +          K   +TKE+      ++  G      E+E ++ KL     K+ +
Sbjct: 2414 TNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL----VKIDL 2469

Query: 3529 LPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPST--------- 3579
               K ++  + E +  +  +  Q+ +  ++ +  +   QQ ++ S++S  T         
Sbjct: 2470 EKMKNAKEFEKEISATKATVEYQKEVIRLLRENLR-RSQQAQDTSVISEHTDPQPSNKPL 2528

Query: 3580 SCG---------------SLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYR 3624
            +CG               S   RL ++ ++L     QL ++KN+L +    L  +++ ++
Sbjct: 2529 TCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWK 2588

Query: 3625 QTGAGRD 3631
            +    R+
Sbjct: 2589 ERTLKRE 2595



 Score =  170 bits (430), Expect = 3e-41
 Identities = 250/1236 (20%), Positives = 559/1236 (45%), Gaps = 184/1236 (14%)

Query: 4    EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTS-SSKHDVSAHHDLNIDQSQC 62
            +E Q+K    + +L +  Q K Q + +  + +  ++ KT  + K   +      + Q + 
Sbjct: 873  QELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD 932

Query: 63   NEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVEL----ESEISTTADDCSSEV 118
            +   +  S ++E   + +S I  T++    T  +   ++E     +  I+T     S EV
Sbjct: 933  DLKQLQESLQIERDQL-KSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEV 991

Query: 119  N-GCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRE 177
            +        TG+  +  +++  G+D     +         ++ ++E+  +Q +I  L +E
Sbjct: 992  SRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQE 1051

Query: 178  LEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQK 237
              E++           Q  E+ I +++ + T L  N++     ++E     L L     K
Sbjct: 1052 KNELQ-----------QMLESVIAEKEQLKTDLKENIEMTIENQEE-----LRLLGDELK 1095

Query: 238  LQIQFQQLQASETLRNSTHSSTAAD-LLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTM 296
             Q +    + +  ++     S   D L + ++++    QQL+E+   L + Q+       
Sbjct: 1096 KQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQE------- 1148

Query: 297  QISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTAD 356
            ++S +Q+KI         ++EN  K E++ KE  +E + T+ +                 
Sbjct: 1149 EMSEMQKKI--------NEIENL-KNELKNKELTLEHMETERL----------------- 1182

Query: 357  KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
                EL +++ +  +E+K++  E    K+ ++    E   L G + E++    +  + E 
Sbjct: 1183 ----ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE-EL 1237

Query: 417  DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK-------- 468
             I     +E Q  +++LR  + E   Q I    Q+L + H    EE+   H+        
Sbjct: 1238 KIAHIHLKEHQETIDELRRSVSEKTAQII--NTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295

Query: 469  ------GEMENALRSYSNITVNEDQIKLMNVAIN--ELNIKLQDTNSQKEKLKEELGLIL 520
                   E  N L   +  +  +D   L  + +    LN K Q++  + + L +E   + 
Sbjct: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355

Query: 521  EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580
              K AL+ + + L E +   RE + + +++ ++QE  LN   K   T      +IVS  E
Sbjct: 1356 TIKEALEVKHDQLKEHI---RETLAKIQESQSKQEQSLNMKEKDNET-----TKIVSEME 1407

Query: 581  SRKELE---LKHEAEVTNYKIKLEMLEKEKNAV------LDRMAESQEAELERLR---TQ 628
              K  +   L+ E E+     +L+    E  +V      L R+ E  ++E ++L+    +
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467

Query: 629  LLFSH---EEELS------KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679
            ++  H   EEEL       K +E+   E R+N+ + +  +    ++Q++ + +++  KI+
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIST-IQKQLEAINDKLQNKIQ 1526

Query: 680  TMQFEKDNLITKQ--------NQL--ILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729
             +  +++    KQ        N+L    E  K KD     + SK  E+T ++ E Q+EI+
Sbjct: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586

Query: 730  ILRQEEKEKGTLEQ--EVQELQLKTELLEKQMKEKENDLQE-KFAQLEAENSILKDEKKT 786
            I+ +E++E   +++  +++  QLK    E   K KE+  +E +F ++ A N       +T
Sbjct: 1587 IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVN-------ET 1639

Query: 787  LEDMLKI-HTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEK 845
             E M +I H     E + + L++I++++      +  +IL E  E+++         + K
Sbjct: 1640 QEKMCEIEHLKEQFETQKLNLENIETEN-----IRLTQILHENLEEMR--------SVTK 1686

Query: 846  QRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRI 905
            +R+     E+  +V   +L          K++L ++  + +LE + +LK ++  +HL+  
Sbjct: 1687 ERDDLRSVEETLKVERDQL----------KENLRETITR-DLEKQEELKIVH--MHLKEH 1733

Query: 906  NPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELS-QRLSDLSE 964
              T  K++  V ++      E   M + +E  + + ++  ++  +E+L ++   L +  E
Sbjct: 1734 QETIDKLRGIVSEKTN----EISNMQKDLE-HSNDALKAQDLKIQEELRIAHMHLKEQQE 1788

Query: 965  QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV 1024
             + +  G +S   +++ +++++ E  + + +E        + + +++ + Q+ +L   V 
Sbjct: 1789 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE--------KIQELKANEHQLITLKKDVN 1840

Query: 1025 TMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKE-SS 1083
                + +E  + ++ K   ++S  +   K+  EN+ + ++  +    L+ + SV KE  +
Sbjct: 1841 ETQKKVSE--MEQLKKQIKDQS--LTLSKLEIENLNLAQKLHEN---LEEMKSVMKERDN 1893

Query: 1084 LRATQPS---ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
            LR  + +   E D+L++ L   K+   +++ +++  R+ LS  +   VD++RE + +EK 
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM-LSKEHKETVDKLREKI-SEKT 1951

Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176
              +  ++++L  +++E  K++Q++ + ELQ ++ +E
Sbjct: 1952 IQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKE 1987



 Score =  149 bits (376), Expect = 5e-35
 Identities = 377/1865 (20%), Positives = 766/1865 (41%), Gaps = 265/1865 (14%)

Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP 1989
            + T +  ++     ++ R  +E++    +L+E+  E +    E++ L++  E        
Sbjct: 330  KNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLE-------- 381

Query: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI-ELEQEKNTEL 2048
             E+ LLQ   K+  EK+E   +       L  Q + L+   + +V+  + ++ + KN+  
Sbjct: 382  -EKDLLQ---KVQNEKIENLTRMLVTSSSLTLQ-QELKAKRKRRVTWCLGKINKMKNSNY 436

Query: 2049 MDLRQQNQALEKQLEKMR----KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104
             D       +  +  K+     + +DE       E DVF   +  L +       + P +
Sbjct: 437  ADQFNIPTNITTKTHKLSINLLREIDESVCS---ESDVFSNTLDTLSEI-----EWNPAT 488

Query: 2105 EHQTRE-VEQLANHLKEKTDKC----SELLLSKEQLQRDIQERNE--EIEKLEFRVR-EL 2156
            +   +E +E   N L+   D       +L   KE+++  ++E+N+  E E LE + + + 
Sbjct: 489  KLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ 548

Query: 2157 EQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKE------ITNLEE 2210
            E  L+      + +         + + ELS +V+L  E++   +K +E      + N++ 
Sbjct: 549  EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM 608

Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIK--ES 2268
             L    E +E+  +  Q L    E    ++      L  EN   K+ M++L    K  E+
Sbjct: 609  DLSYSLESIEDPKQMKQTL-FDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEN 667

Query: 2269 DAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL--KITTDNKVIEEKNELIRD 2326
            D    Q Q +   K  Q+  EKE++    NE +TKL   +  K+  D     E    I D
Sbjct: 668  DIQLYQSQ-LEAKKKMQVDLEKELQ-SAFNE-ITKLTSLIDGKVPKDLLCNLELEGKITD 724

Query: 2327 LETQIECLMSDQECVKRNREE-----EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
            L+ ++   + + E +   REE     E++ L   +E+L++E+    Q  S   H ++ E 
Sbjct: 725  LQKELNKEVEENEAL---REEVILLSELKSLPSEVERLRKEI----QDKSEELHIITSEK 777

Query: 2382 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2441
            D L        +E +  E +V+   EE+   K+ L  T        QE  + K      E
Sbjct: 778  DKL-------FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFE 830

Query: 2442 KIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRL 2501
            +                     + ++VL E+   + E     K  ++         ++ L
Sbjct: 831  Q---------------------KYKMVLEENERMNQEIVNLSKEAQK--------FDSSL 861

Query: 2502 LQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL 2561
              L++ +S K  EL +  +++++   + +   E L+ +   LQ +  EK    L+++   
Sbjct: 862  GALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKT---LITEKLQ 918

Query: 2562 EAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTS 2621
            + ++E     Q+   +        +Q   Q+  D+L SDI        + + Q+     S
Sbjct: 919  QTLEEVKTLTQEKDDLKQ------LQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES 972

Query: 2622 LILEKEQVEIAEKNVLEKEKKLLELQKLL-EGNEKKQREKEKKRSPQDVEVLKTTTELFH 2680
            L   +E +   +  + E+  + L +++   E  ++ Q++       QD+E   T T    
Sbjct: 973  LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTAD 1032

Query: 2681 SNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHL 2740
              +             E +  + ++ S  ++  +LQ+ L         L+ DL +  +  
Sbjct: 1033 VKDN------------EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080

Query: 2741 AEAKEKLSIL----EKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQ 2796
             E +E+L +L    +K+ E   QE   A   E    +LS++     +   K+   +Q  Q
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEG---ELSRTCDRLAEVEEKLKEKSQ--Q 1135

Query: 2797 ILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKRE 2856
            +  K   + +N+Q E         +S+  +KI +++ L      +++++ ++  E ++ E
Sbjct: 1136 LQEKQQQL-LNVQEE---------MSEMQKKINEIENLKN----ELKNKELT-LEHMETE 1180

Query: 2857 HYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLT 2916
                 Q L E    +K++     +KE   + EL  S  ++T          D  +G Y+ 
Sbjct: 1181 RLELAQKLNENYEEVKSI-----TKERKVLKELQKS--FETER--------DHLRG-YIR 1224

Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
              +   + ++   + +        + I  L R+V  +  Q+++  +   S    H+  Q 
Sbjct: 1225 EIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKS----HTKLQE 1280

Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQREAEVY-DSSQSHESFSDWRGEL-LLALQQVF 3034
              P L E +     + ++K++    +   E E+  + S + +S +  R E+  L L + F
Sbjct: 1281 EIPVLHEEQ---ELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337

Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI 3094
             E +  + +  +         +A   L     +++E   E  A ++  Q    +SL  + 
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEA---LEVKHDQLKEHIRETLAKIQESQSKQEQSLNMK- 1393

Query: 3095 QALHAQMNGRKITLKREQESEKPSQEL-LEYNIQQKQSQMLEMQVELSSM---KDRATEL 3150
                      KI  + EQ   K S  L +E  +     ++ E   E+ S+   KD    L
Sbjct: 1394 ---EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRL 1450

Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE----AFRLEVKDKTDEVHLL 3206
            QE L SE   + E   E+    LE E  LK  H  LKE E      R+ + +K  E+  +
Sbjct: 1451 QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTI 1510

Query: 3207 NDTL-ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ 3265
               L A   K   ++Q   EKE+    +     +E++ +LK   E +K ++  L      
Sbjct: 1511 QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSAL------ 1564

Query: 3266 QKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3325
                     Q IES+ +    +L E Q    E+Q++++ EK  ++ +   L  ER+   Q
Sbjct: 1565 ---------QSIESKMLELTNRLQESQE---EIQIMIK-EKEEMKRVQEALQIERD---Q 1608

Query: 3326 LQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRI-VELLNETEKYKLDSLQTRQQMEKDR 3384
            L+ +           +++++ ++++  E+++  + +  +NET++   +    ++Q E  +
Sbjct: 1609 LKEN-----------TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE-TQ 1656

Query: 3385 QVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQ 3444
            +++ + ++TE   N    + +HE   ++  + ++ ++ R     L +E  +L+  ++E  
Sbjct: 1657 KLNLENIETE---NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI 1713

Query: 3445 KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ-----KIEGETKESNYAKLI 3499
             ++L   EK+E  +I++ +L E      T D+ R  V ++      ++ + + SN A   
Sbjct: 1714 TRDL---EKQEELKIVHMHLKEHQE---TIDKLRGIVSEKTNEISNMQKDLEHSNDA--- 1764

Query: 3500 EMNGGGTGCNHELEMIRQKL---QCVASKLQVLPQKASERLQFETADDEDF-IWVQENID 3555
             +         EL +    L   Q    KL+ +  + +++L     D E+    +QE I 
Sbjct: 1765 -LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQ 1823

Query: 3556 EIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMK 3615
            E+     +L   + +    V+ +    S  E+L +Q  + +  +S+L  E     N+  K
Sbjct: 1824 ELKANEHQLITLKKD----VNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN---LNLAQK 1876

Query: 3616 LEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK 3675
            L E +   +     RDN  R                +E    E+  L++SL+  +A   +
Sbjct: 1877 LHENLEEMKSVMKERDNLRRV---------------EETLKLERDQLKESLQETKARDLE 1921

Query: 3676 LKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDA 3735
            ++ EL+   +L     ++     ++I  K ++    +K L   K  L   +   QE +  
Sbjct: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKI---QELQKK 1978

Query: 3736 TLALL 3740
             L LL
Sbjct: 1979 ELQLL 1983


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  230 bits (586), Expect = 2e-59
 Identities = 461/2386 (19%), Positives = 993/2386 (41%), Gaps = 346/2386 (14%)

Query: 236  QKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFT 295
            QK+  + QQLQ +     ++ +S+    ++++    T Q      +    D Q   +   
Sbjct: 7    QKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQ 66

Query: 296  MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL-KDKLTT 354
            +++  ++    ++     + +  S+ +E   + +  E LN   ++    + +   D  + 
Sbjct: 67   LRVPSVES---LFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSE 123

Query: 355  ADKLLGEL----QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK 410
            A+ L+G      +EQ++Q+   ++ M+  L++ + K  +        + T  ++ +R  K
Sbjct: 124  AEDLVGNSDSLNKEQLIQR---LRRMERSLSSYRGKYSE--------LVTAYQMLQREKK 172

Query: 411  DSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGE 470
              Q    I+ + + ++ R++ +LR EL     Q   Q K+ L  +  A +EE     K +
Sbjct: 173  KLQ---GILSQSQDKSLRRIAELREEL-----QMDQQAKKHLQEEFDASLEE-----KDQ 219

Query: 471  MENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS--QKEKLKEELGLILEEKCALQR 528
              + L++  ++     +   MNV + +   +L+       KE+  E  G  + E     +
Sbjct: 220  YISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279

Query: 529  QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
             LE L + +      ++R ++TI   + +          +++   E +   E  K+L + 
Sbjct: 280  TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA 339

Query: 589  HEA----EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDL 644
             +     ++ + K  +E LE++K  V+        AE +R   + L   EEE+++L+  +
Sbjct: 340  EKTKLITQLRDAKNLIEQLEQDKGMVI--------AETKRQMHETLEMKEEEIAQLRSRI 391

Query: 645  EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD-NLITKQNQLILEISKLK 703
            + +     E+L++             Q E S++    + EK  +   K  +   ++    
Sbjct: 392  K-QMTTQGEELRE-------------QKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437

Query: 704  DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE--KGTLEQEVQELQLKTELLEKQMKE 761
            D Q   +   SEE  +    LQ+E+  ++QE  +  K + E+++ +LQ   +L EK++  
Sbjct: 438  DEQIKTIEKTSEEERIS---LQQELSRVKQEVVDVMKKSSEEQIAKLQ---KLHEKELAR 491

Query: 762  KENDLQEKFAQLEAE--NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE 819
            KE +L +K    E E    +    +K+  + LKI     Q+E L  L+ ++ + K  + E
Sbjct: 492  KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA-LEELELQKKAILTE 550

Query: 820  KEIEI--LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY-----ACLL 872
             E ++  L +E E  + + ++L   +EK         K+  V+ +  + ++       + 
Sbjct: 551  SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610

Query: 873  KVKDDLEDSKNKQELEYKSKLKALNEELH--LQRINPTTVKMKSSVF-DEDKTFVAETLE 929
            K K +LE  K++Q+  +  KL+ L ++    ++++     + K ++  D++  F A   E
Sbjct: 611  KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670

Query: 930  MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989
            M E       + +EKL+V + E   LS   S+LSE LK +H     L EE+  LK + ++
Sbjct: 671  MNE-------KTLEKLDVKQTELESLS---SELSEVLKARHK----LEEELSVLKDQTDK 716

Query: 990  VSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM 1049
            +    +ELE  ++  +  + Q  D+ +    +  +  T +  +  ++++     E  K +
Sbjct: 717  MK---QELEAKMDEQKNHHQQQVDSIIKE-HEVSIQRTEKALKDQINQLELLLKERDKHL 772

Query: 1050 VEDKVSFENMTVGEESKQEQL--------ILDHLPSVTKESSLRATQPSENDKLQKELNV 1101
             E +   EN+    +  + +L        +     S T E +       +  +LQ++L  
Sbjct: 773  KEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT--KAYEEQLAQLQQKLLD 830

Query: 1102 LKSEQNDLRLQ---MEAQRICLSLVYSTHVDQVREYME------NEKDKALCSLKEELIF 1152
            L++E+  L  Q   +EAQ+  +      H  QV++ M+      +E ++ + SL +    
Sbjct: 831  LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYES 890

Query: 1153 AQEEKIKELQKIHQL--ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVL 1210
              E+  KE ++  Q+  E + M  Q    + K + +L  KL  +  E+  +       +L
Sbjct: 891  KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL--SAKEDSIH-------IL 941

Query: 1211 GEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKL 1270
             E Y    K                 N++ +++  + + ++ QE   TL  K+ ++  KL
Sbjct: 942  NEEYETKFK-----------------NQEKKMEKVKQKAKEMQE---TLKKKLLDQEAKL 981

Query: 1271 LVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQD 1330
                   +    Q+    + +F  + L   +     I   ++ LE    N K ++ SL +
Sbjct: 982  KKELENTALELSQK----EKQFNAKMLEMAQANSAGISDAVSRLE---TNQKEQIESLTE 1034

Query: 1331 LEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVV 1390
            + + +L + +   E     L QQ +E ++ +E +   LQ++ Q V+E             
Sbjct: 1035 VHRRELNDVISIWE---KKLNQQAEELQEIHEIQ---LQEKEQEVAEL------------ 1076

Query: 1391 ITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVS 1450
                  Q+ +  G C K+ ++  I +  E GVK++T + +L E+  Q+           +
Sbjct: 1077 -----KQKILLFG-CEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130

Query: 1451 MSIAFAQQTELSRISGGKENTASSKQ---AHAVCQQEQHYFNEM--KLSQDQIGFQTFET 1505
               A  ++ E+      KENT   +Q      + ++++   +E+  KL      FQ+ ++
Sbjct: 1131 KLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS 1190

Query: 1506 VDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSI 1565
               K  +  +  S E  +  +E                  L I  ++  K    ++    
Sbjct: 1191 SHEKSNKSLEDKSLEFKKLSEE------------------LAIQLDICCKKTEALLEAKT 1232

Query: 1566 HDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ 1625
            ++ I++SS  +    +L+       R   V++    +  T    +A +RQ+    E+Q  
Sbjct: 1233 NELINISS--SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL---TEEQNT 1287

Query: 1626 LQEEIKRLNRQLAQRSS------IDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
            L    ++   QL ++ +       D E+LV+E+E +   + E   Q   A  ++ C    
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---QKEGGNQQQAASEKESCI--- 1341

Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVV 1739
                 TQ   E    +   T  ++EL  K  ++    LS +                   
Sbjct: 1342 -----TQLKKELSENINAVTLMKEELKEKKVEI--SSLSKQ------------------- 1375

Query: 1740 KTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE-SIPSY 1798
                            + D + + Q+S SL  +  A +S++    EE   + D+    S+
Sbjct: 1376 ----------------LTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSF 1419

Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEK-- 1856
                + +  I+   +V +   + S+   ++    T+     +EL + +  + + A EK  
Sbjct: 1420 KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDE 1479

Query: 1857 ----LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQ 1912
                L E + + + + +  K    +   +  +++      LK Q     R+ E      Q
Sbjct: 1480 QINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ---TARIMELEDHITQ 1536

Query: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE 1972
              +E+     V+  Y  +K +  +++ +K      L +E     NR++E E       E+
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEE---KDNRVKEAE-------EK 1586

Query: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032
               L  Q  +MKAE    +++L      +  ++ E++   +++  +   ++  L+   E+
Sbjct: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646

Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE- 2091
            +++        K   L  + ++ +  +K  E     L+ +  +RE E  + +++++ +E 
Sbjct: 1647 KIAAI------KKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700

Query: 2092 --QQLKVVPRFQPISEHQTREVEQLANHLKEKT--DKCSEL---LLSKEQLQRDIQERNE 2144
               +  +VPR        T + E  +    +KT  +K S L   L  KE+L + + +  E
Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE 1760

Query: 2145 EIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKE 2204
            E     F +R   Q  L+     +  E ++H        + S+   LQ E +  ++K   
Sbjct: 1761 ETVSSHFEMRCQYQERLIK---LEHAEAKQH-------EDQSMIGHLQEELEEKNKKYSL 1810

Query: 2205 ITNLEEQLE------QFREELENKNEEVQQLHMQLEIQKKESTTRLQELE----QENKLF 2254
            I     + E      Q ++ LEN  ++VQ+   + E+  +    +++EL+    ++ ++ 
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870

Query: 2255 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2314
            + +ME+L    ++  A+   D      K  ++++E   E  + +    KL   ++   ++
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGR---NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHND 1927

Query: 2315 ---KVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQL-----NEVIEKLQQELANI 2366
               K+   + E  + L  +I  L  D   +++  ++E+E L      E  EK++QE  ++
Sbjct: 1928 LEFKLAGAEREK-QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986

Query: 2367 GQKTSMNAHSLSEEADS----LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422
              K +     L  E ++     + +L++ I E +   Q+VE        +++  +ETN  
Sbjct: 1987 ELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEA-----ELLESHQEETNQL 2041

Query: 2423 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2482
            + ++ ++   LKR  +  E+I    E  +   +  L     EL+        K  + +  
Sbjct: 2042 LKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ--------KKYQQKLE 2093

Query: 2483 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
             +    N   +I+ L+T+L Q  + +S   L+  +  +QI +++++
Sbjct: 2094 QEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDR 2139



 Score =  223 bits (568), Expect = 3e-57
 Identities = 451/2272 (19%), Positives = 930/2272 (40%), Gaps = 397/2272 (17%)

Query: 693  NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKE--IEILRQEEKEKGTLEQEVQELQL 750
            N+L L+ S       S ++S++E++    + L KE  I+ LR+ E+   +   +  EL  
Sbjct: 103  NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT 162

Query: 751  KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
              ++L+++ K+ +  L +   +     + L++E + ++   K H    QEE   F  S++
Sbjct: 163  AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQ-MDQQAKKHL---QEE---FDASLE 215

Query: 811  SKSKD-SVWEKEIEILIEE------NEDLKQQCIQLNEEIE---KQRNTFSFAE------ 854
             K +  SV + ++ +L +       N D+ +   QL  + E   K+ N  S  E      
Sbjct: 216  EKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDG 275

Query: 855  ---KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL-----HLQRIN 906
               K  E   Q ++ +   L + K+ ++  K +  L   S+ +AL E+L      L++I 
Sbjct: 276  TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL-LTSEKEALQEQLDERLQELEKIK 334

Query: 907  PTTVKMKSSVFDE--DKTFVAETLEM--GEVVEKDTTELMEKLEVTKREKLELSQRLSDL 962
               +  K+ +  +  D   + E LE   G V+ +   ++ E LE+ + E  +L  R+  +
Sbjct: 335  DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394

Query: 963  SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDG 1022
            + Q            EE++  K++ E+ +    ELE  ++   A+  +    ++ + +D 
Sbjct: 395  TTQ-----------GEELREQKEKSERAAFE--ELEKALS--TAQKTEEARRKLKAEMDE 439

Query: 1023 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKES 1082
             +    + +E                  E+++S +     E S+ +Q ++D +   ++E 
Sbjct: 440  QIKTIEKTSE------------------EERISLQQ----ELSRVKQEVVDVMKKSSEEQ 477

Query: 1083 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142
              +  +  E +  +KE  + K  Q                       + RE+ E  K   
Sbjct: 478  IAKLQKLHEKELARKEQELTKKLQT----------------------REREFQEQMKVAL 515

Query: 1143 LCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202
              S  E L  +QE++ +E   + +LELQ                     +KA+  E    
Sbjct: 516  EKSQSEYLKISQEKEQQESLALEELELQ---------------------KKAILTESENK 554

Query: 1203 LQTLCSVLGEYYTPALKCEVNAE----DKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258
            L+ L      Y T  L+ E + E    + +N    ++ + + E   +  E+    E   T
Sbjct: 555  LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614

Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318
             L  +  + + L          W ++   +K ++  E    E+        + T L+D +
Sbjct: 615  ELESLKHQQDAL----------WTEKLQVLKQQYQTE---MEKLREKCEQEKETLLKDKE 661

Query: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
            +  ++ +  + +    KL+ +  ELESL S L + LK          H L++ L  + + 
Sbjct: 662  IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR--------HKLEEELSVLKDQ 713

Query: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQE 1438
            T      +++ +  E          S +K++ + +I+ + E  +K++ N ++LL K+  +
Sbjct: 714  TDKMKQELEAKM-DEQKNHHQQQVDSIIKEH-EVSIQRT-EKALKDQINQLELLLKERDK 770

Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQI 1498
             L+E                                 QAH    +     +E +L Q   
Sbjct: 771  HLKEH--------------------------------QAHVENLEADIKRSEGELQQASA 798

Query: 1499 GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558
                F++      E+ K   ++L +  +++L                          ++ 
Sbjct: 799  KLDVFQSYQSATHEQTKAYEEQLAQLQQKLL----------------------DLETERI 836

Query: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
             + +Q    E+     D   +L  ++ Q++D+ Q+L +Q  E +Q  + L Q +  ++E 
Sbjct: 837  LLTKQVA--EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894

Query: 1619 QREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678
              ++QEQ ++ +            ++ EN++ +      +E+E L Q   A  + +   +
Sbjct: 895  GNKEQEQTKQIL------------VEKENMILQMREGQKKEIEILTQKLSAKEDSI--HI 940

Query: 1679 RNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738
             N   +T+  N+ + ++E+   K KE+    E +  ++L  E    ++  N  L++  + 
Sbjct: 941  LNEEYETKFKNQEK-KMEKVKQKAKEMQ---ETLKKKLLDQEAKLKKELENTALELSQKE 996

Query: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
             +  A + E    +  GI D  S+ +++      S  E   +     +   + ++ +   
Sbjct: 997  KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL--NDVISIWEKKLNQQ 1054

Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL--MLNISSRLQAAVEK 1856
            +      ++I +  K  +E  EL Q+++     G E +  N+E+  +     +    + +
Sbjct: 1055 AEELQEIHEIQLQEK-EQEVAELKQKIL---LFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110

Query: 1857 LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL-------HEESRA 1909
            L E + + S+ +      +T+L     + + +  +SLK    L+E+L        E+ R 
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRK 1170

Query: 1910 REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL-----LCASNRLQELEA 1964
              +L  +L   +              + +++K+    +L +EL     +C       LEA
Sbjct: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA 1230

Query: 1965 EQQQI-----QEERELLSR----------QKEAM---KAEAGPVEQQLLQETEKLMKEKL 2006
            +  ++      +   +LSR           KEA+         +E QL Q TE+     +
Sbjct: 1231 KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290

Query: 2007 EVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ--LEK 2064
              Q QA    ++ + Q+K+++ D+E  V+    L++E         QQ  A EK+  + +
Sbjct: 1291 SFQ-QATHQLEEKENQIKSMKADIESLVTEKEALQKEGG------NQQQAASEKESCITQ 1343

Query: 2065 MRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLAN--HLKEKT 2122
            ++K L E         ++    + K E + K V     +S+  T    QL N   L EK 
Sbjct: 1344 LKKELSE---------NINAVTLMKEELKEKKV-EISSLSKQLTDLNVQLQNSISLSEKE 1393

Query: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVED-RKHFGAVEA 2181
               S L   ++Q   +  E  ++++ L F+V  L +  +      ++V+D    F   + 
Sbjct: 1394 AAISSL---RKQYDEEKCELLDQVQDLSFKVDTLSKEKI---SALEQVDDWSNKFSEWKK 1447

Query: 2182 KPE----------LSLEVQLQAERDAIDRKEKEITNLEEQLEQ-------FREELENKNE 2224
            K +            L++QL+ +      K+++I  L+E+L+Q        + E+E+   
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKS 1507

Query: 2225 EVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFA 2284
            ++++    LE + K  T R+ ELE        ++E L   +K  +               
Sbjct: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN--------------- 1552

Query: 2285 QIIQEKEVEIDQLNEQVTKLQ--QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2342
               Q+K++E  +L   V KLQ  Q+L    DN+V +E  E I  LE Q+  + ++ E   
Sbjct: 1553 ---QQKDIEHKEL---VQKLQHFQELGEEKDNRV-KEAEEKILTLENQVYSMKAELE--- 1602

Query: 2343 RNREEEIEQLNEVIEKLQQELANIGQK-TSMNAHSLSEEADSLKHQLDVVIA--EKLALE 2399
              +++E+E +N  ++  ++EL  +  +  S +A  L+E    LK + +  IA  +K  L 
Sbjct: 1603 -TKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE----LKRKAEQKIAAIKKQLLS 1657

Query: 2400 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS----IPENSVNVAI 2455
            Q  E   +     ++ L E N K+ +  +E+  L+ + +SVE  QS    +P ++ NVA 
Sbjct: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA- 1716

Query: 2456 DHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSI-INLETRLLQLESTVSAKDLE 2514
                                      Y +  E + +G +    E ++  L+  ++ K+ +
Sbjct: 1717 -------------------------AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE-K 1750

Query: 2515 LTQCYKQIKDMQEQGQFETE-MLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQ 2572
            L Q   Q K+      FE     Q++++ L+    ++    +++  +Q E  ++  K+  
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810

Query: 2573 -DNQTISSEPERTNIQNLNQLRE--DELGSDISALTLRISELESQVVEMHTSLILEKEQV 2629
               Q +  E  + NIQ    L    D++   +    L    LE ++ E+ + L+ +KE  
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870

Query: 2630 EIAEKNVLEKEKKLLELQKLLEGNEK-----KQREKEKKRSPQDVEVLKTTTELFHSNEE 2684
             +  + +  K +KL  LQ+ ++G  K     ++  +EK +S      L +  E  H++ E
Sbjct: 1871 RVEMEELTSKYEKLQALQQ-MDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLE 1929

Query: 2685 ---SGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLA 2741
               +G   E + L  E V  + +L   + K  + + E+L KE +    +K   +  D   
Sbjct: 1930 FKLAGAEREKQKLGKEIVRLQKDLRMLR-KEHQQELEILKKEYDQEREEKIKQEQEDLEL 1988

Query: 2742 EAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
            +    L  L +E  T++ + ++      + IK + + A + +  L  S   +T Q+L K 
Sbjct: 1989 KHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045

Query: 2802 AGIQINLQS---------ECSSEEVTEIISQFTEKIEKMQELHAAEILDMES 2844
            A    +L+          +   EE+T  +     ++E++Q+ +  ++   E+
Sbjct: 2046 AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097



 Score =  218 bits (555), Expect = 9e-56
 Identities = 399/1886 (21%), Positives = 822/1886 (43%), Gaps = 314/1886 (16%)

Query: 157  LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
            LEM E E+A  +  I+++  + EE+R           +E E A+              ++
Sbjct: 377  LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL--------STAQKTEE 428

Query: 217  ARR----EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT 272
            ARR    E DE ++  +E T + +++ +Q +  +  + + +    S+   +  AK Q L 
Sbjct: 429  ARRKLKAEMDEQIKT-IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQI--AKLQKLH 485

Query: 273  HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV-YEMEQDKKVENSNKEEIQEKETII 331
             ++   ++  L +  Q ++ +F       QE++KV  E  Q + ++ S ++E QE   + 
Sbjct: 486  EKELARKEQELTKKLQTREREF-------QEQMKVALEKSQSEYLKISQEKEQQESLALE 538

Query: 332  E-ELNTKII--EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKER 388
            E EL  K I  E E K  +L+ +  T    + EL+  + +  QE KN   +L  +   E 
Sbjct: 539  ELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL--AVHLEA 596

Query: 389  QSSEEIKQLMGTVE----ELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 444
            + ++  K++   VE    EL+   H+     T+ +Q ++Q+ Q ++E+LR E  E   + 
Sbjct: 597  EKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR-EKCEQEKET 655

Query: 445  IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504
            +++ K+ + + H+ +M E         +  L S S+     + +K  +    EL++    
Sbjct: 656  LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL--SEVLKARHKLEEELSVLKDQ 713

Query: 505  TNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRA-RQTIAEQESKLNEAHK 563
            T+  K++L+ ++    E+K   Q+Q++ +++E   S ++ ++A +  I + E  L E  K
Sbjct: 714  TDKMKQELEAKMD---EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770

Query: 564  SL----STVEDLKAEIVSASESRKELELK-----------------HEAEVTNYKIKLEM 602
             L    + VE+L+A+I  +    ++   K                 +E ++   + KL  
Sbjct: 771  HLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830

Query: 603  LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662
            LE E+  +  ++AE  EA+ + + T+ L +H+ ++  L + LE ++    +K+K    ++
Sbjct: 831  LETERILLTKQVAE-VEAQKKDVCTE-LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888

Query: 663  YKQQIDGLQNEMSQKIETMQFEKDNLITK----QNQLILEISKLKDLQQSLVNSKSEEMT 718
              +  DG  N+  ++ + +  EK+N+I +    Q + I  +++    ++  ++  +EE  
Sbjct: 889  ESKLEDG--NKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946

Query: 719  LQINELQKEIEILRQEEKE-KGTLEQEV--QELQLKTEL--LEKQMKEKENDLQEKFAQL 773
             +    +K++E ++Q+ KE + TL++++  QE +LK EL     ++ +KE     K  ++
Sbjct: 947  TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006

Query: 774  EAENSI-LKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD---SVWEKEIEILIEEN 829
               NS  + D    LE         +Q+E++  L  +  +  +   S+WEK++    EE 
Sbjct: 1007 AQANSAGISDAVSRLE--------TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058

Query: 830  EDLKQQCIQLNEEIEKQRNTFSFAEK--NFEVNYQELQEEYACLLK--VKDDLEDSKNKQ 885
            +++ +  IQL    EK++      +K   F    +E+ +E   L +  VK D   ++ ++
Sbjct: 1059 QEIHE--IQLQ---EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQE 1113

Query: 886  ELEYKS-----------KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL-EMGEV 933
            +L+ KS           KLKA     HL+++    V +  S+  ++ TF+ E L E+  +
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKA-----HLEKLE---VDLNKSL--KENTFLQEQLVELKML 1163

Query: 934  VEKD---TTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990
             E+D    +EL  KL+ T  E   L       ++ L+ K  E   L+EE+        Q+
Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI------QL 1217

Query: 991  SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE---------GSVSKVNKS 1041
             + C++ E ++     E +    ++ +++L  +     R  +          +VS++   
Sbjct: 1218 DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQ 1277

Query: 1042 FGEESKIMVEDKVSFENMTVGEESKQEQL---------ILDHLPSVTKESSLRATQPSEN 1092
              + ++      +SF+  T   E K+ Q+         ++    ++ KE   +    SE 
Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337

Query: 1093 D----KLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMEN-----EKDKAL 1143
            +    +L+KEL+   +    ++ +++ +++ +S + S  +  +   ++N     EK+ A+
Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEKKVEISSL-SKQLTDLNVQLQNSISLSEKEAAI 1396

Query: 1144 CSLKEELIFAQEEKIKELQKIHQLELQT-MKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202
             SL+++     EEK + L ++  L  +    ++E     + +     K  +   +  S F
Sbjct: 1397 SSLRKQY---DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRF 1453

Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDP----------ELQDYRYEVQDF 1252
             Q   +V        LK +  A +K+   + + E  D           E++D + +++  
Sbjct: 1454 TQHQNTVKELQIQLELKSK-EAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKK 1512

Query: 1253 QENMHT------------------------LLNKVTEEYN-------KLLVLQTRLSKIW 1281
            + N+ T                         LN+V + YN       K LV + +  +  
Sbjct: 1513 ESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQEL 1572

Query: 1282 GQQTDGMKLEFGEENLPKEETEF---LSIHSQMTNLEDIDVNHKSKLSSLQDLE------ 1332
            G++ D    E  E+ L  E   +     + ++   LE ++++ KSK   L+ LE      
Sbjct: 1573 GEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE 1632

Query: 1333 -KTKLEEQVQELESLISSLQQQL----KETEQNY------------------EAEIHCLQ 1369
               KL E  ++ E  I+++++QL    +E E+ Y                  E E+H L+
Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692

Query: 1370 KRLQAV----SESTVPPSLPVDSVVITESD-------AQRTMYPG-SCVKKNI------- 1410
            ++L++V    SE+ + P    +    TE +        Q+T     S +++N+       
Sbjct: 1693 EKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLL 1752

Query: 1411 -------DGTIEFSGEFGVKEETNIVKLLE---KQYQEQ-----LEEEVAKVIVSMSIAF 1455
                   + T+    E   + +  ++KL     KQ+++Q     L+EE+ +     S+  
Sbjct: 1753 QRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIV 1812

Query: 1456 AQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD---VKFKE 1512
            AQ  E     GGK N  + +    V    Q    E +L+  QI  Q  + +D   V+ KE
Sbjct: 1813 AQHVEK---EGGKNNIQAKQNLENVFDDVQKTLQEKELT-CQILEQKIKELDSCLVRQKE 1868

Query: 1513 EFKPLSKEL-GEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISV 1571
              +   +EL  ++ K   L   D  + P        + E    K K+ +V+  +   +  
Sbjct: 1869 VHRVEMEELTSKYEKLQALQQMDGRNKPTE-----LLEENTEEKSKSHLVQPKLLSNMEA 1923

Query: 1572 SSMDASRQLMLNEEQLEDMRQELVRQY-------QEHQQATELLRQAHMRQMERQ-REDQ 1623
               D   +L   E + + + +E+VR         +EHQQ  E+L++ + ++ E + +++Q
Sbjct: 1924 QHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQ 1983

Query: 1624 EQLQ--------EEIKRLNRQLAQRS---SIDNENLVSERERVLLEELEALKQLSLAGRE 1672
            E L+        + ++  N QLAQ+     +  +  +++ + V  E LE+ ++ +    +
Sbjct: 1984 EDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLK 2043

Query: 1673 KLCCELRNSSTQTQNGNEN--QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNR 1730
            K+  E  +   +T    E       EE T K ++L  + E++  +    ++   Q+ N  
Sbjct: 2044 KI-AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKY---QQKLEQEENPG 2099

Query: 1731 LLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRV 1790
               + +  ++T  A + T+      I D   K Q     I   E         +E++   
Sbjct: 2100 NDNVTIMELQTQLAQKTTL------ISDSKLKEQEFREQIHNLEDRLK----KYEKNVYA 2149

Query: 1791 TDESIPSYSGSDMPRNDINMWSKVTE 1816
            T    P Y G ++   D++++ + TE
Sbjct: 2150 TTVGTP-YKGGNLYHTDVSLFGEPTE 2174



 Score =  199 bits (505), Expect = 6e-50
 Identities = 461/2180 (21%), Positives = 910/2180 (41%), Gaps = 375/2180 (17%)

Query: 1762 KSQSSASLIWRSEAEASVKSCVHEEHTRVT-DESIPSY---SGSDMPRNDINMWSKVTEE 1817
            +S    SL   S  E+ V++   E   R+  D S  S+   S  D    D+ + +  +  
Sbjct: 77   RSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDL-VGNSDSLN 135

Query: 1818 GTELSQRLVR-----SGFAGTEIDPENEELMLNISSR-----LQAAVEKLLEAISETSSQ 1867
              +L QRL R     S + G   +      ML    +     L  + +K L  I+E   +
Sbjct: 136  KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195

Query: 1868 LEHAKVTQTELMRE---SFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924
            L+  +  +  L  E   S  +K +    L+ Q  L ++          +   L + E   
Sbjct: 196  LQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQA 255

Query: 1925 DGYADEKTLF---ERQIQEKTDI--IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 1979
            + +  E+      E  +++ T +  ++ L+Q +    N L+  +   Q  +E+  LL+ +
Sbjct: 256  EVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSE 315

Query: 1980 KEAMKAEAGPVEQQLLQETEKL----MKEKLEVQCQ---AEKVRDDLQKQVKALEIDVEE 2032
            KEA++ +      + LQE EK+    M EK ++  Q   A+ + + L++    +  + + 
Sbjct: 316  KEALQEQL----DERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR 371

Query: 2033 QVSRFIELEQEKNTELM-----------DLRQQN--------QALEKQL----------E 2063
            Q+   +E+++E+  +L            +LR+Q         + LEK L           
Sbjct: 372  QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431

Query: 2064 KMRKFLDEQ--AIDR--EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK 2119
            K++  +DEQ   I++  E ER   QQE+ +++Q+  VV   +  SE Q  ++++L  H K
Sbjct: 432  KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQE--VVDVMKKSSEEQIAKLQKL--HEK 487

Query: 2120 EKTDKCSELLLSKEQLQRDIQER------------------NEEIEKLEFRVRELEQALL 2161
            E   K  EL    +  +R+ QE+                   E+ E L     EL++  +
Sbjct: 488  ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI 547

Query: 2162 VS------ADTFQKVED-RKHFGAVEAKPELSLE----------VQLQAERDAIDRKEKE 2204
            ++       D  Q+ E  R     +E+  E SL+          V L+AE+   ++  KE
Sbjct: 548  LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEK---NKHNKE 604

Query: 2205 ITNLEEQLEQFREELENKNEEVQQLHMQ-LEIQKKESTTRLQEL----EQENK-LFKD-- 2256
            IT +   +E+ + ELE+   +   L  + L++ K++  T +++L    EQE + L KD  
Sbjct: 605  ITVM---VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKE 661

Query: 2257 -------------DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 2303
                          +EKL +   E +++S++   VL  +      + E E+  L +Q  K
Sbjct: 662  IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR-----HKLEEELSVLKDQTDK 716

Query: 2304 LQQQLKITTDNK-----------------VIEEKNELIRDLETQIECLMSDQECVKRNRE 2346
            ++Q+L+   D +                  I+   + ++D   Q+E L+ +++   +  +
Sbjct: 717  MKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQ 776

Query: 2347 EEIEQLNEVIEKLQQELANIGQK----------TSMNAHSLSEEADSLKHQLDVVIAEKL 2396
              +E L   I++ + EL     K          T     +  E+   L+ +L  +  E++
Sbjct: 777  AHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERI 836

Query: 2397 ALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAID 2456
             L +QV     +   +   L     ++  L Q+L   K+  E  +K++S+ +      ++
Sbjct: 837  LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL--EKQNSEMEQKVKSLTQ-VYESKLE 893

Query: 2457 HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELT 2516
              +K++ + + +L       +E +       E  K  I  L  +L   E ++   + E  
Sbjct: 894  DGNKEQEQTKQIL-------VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946

Query: 2517 QCYK-QIKDMQEQGQFETEM---LQKKIVNLQ-KIVEEKVAAAL-VSQIQLEAVQEYAKF 2570
              +K Q K M++  Q   EM   L+KK+++ + K+ +E    AL +SQ + +   +  + 
Sbjct: 947  TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006

Query: 2571 CQDNQTISSEP-------ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI 2623
             Q N    S+        ++  I++L ++   EL   IS    ++++   ++ E+H   +
Sbjct: 1007 AQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL 1066

Query: 2624 LEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE 2683
             EKEQ E+AE          L+ + LL G EK++  KE     +  E +K  T L    E
Sbjct: 1067 QEKEQ-EVAE----------LKQKILLFGCEKEEMNKEITWLKE--EGVKQDTTLNELQE 1113

Query: 2684 ESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEA 2743
                  +L+   A   +   +    K   EKL+ +L       T LQ+ L +++    E 
Sbjct: 1114 ------QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED 1167

Query: 2744 KEKLSILEKEDETEVQE----------SKKACMFEPLPI-KLSKSIASQTDGTLKISSSN 2792
            K K+S L  + +T  +E          S K+   + L   KLS+ +A Q D   K     
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK----- 1222

Query: 2793 QTPQILVKNAGIQINLQSECSSEEVTEI--ISQFTEKIEKMQELHAAEILDMES--RHIS 2848
            +T  +L       IN+ S  ++  ++ I      T K+++   +    + ++E+  R ++
Sbjct: 1223 KTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLT 1282

Query: 2849 ETE-TLKREHYVAVQLLKE---ECGTLKAVIQCL-RSKEGSSIPELAHSDAYQTREICSS 2903
            E + TL      A   L+E   +  ++KA I+ L   KE           A   +E C +
Sbjct: 1283 EEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCIT 1342

Query: 2904 DSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTES 2963
                +  + I        ++      +E +    S  K++  L   + N     +SL+E 
Sbjct: 1343 QLKKELSENINAVTLMKEEL------KEKKVEISSLSKQLTDLNVQLQNS----ISLSE- 1391

Query: 2964 PYSDGEDHSIQQVSEPWLEERKAYINTISSLK---DLITKMQLQREAEVYDSSQSHESFS 3020
                 ++ +I  + + + EE+   ++ +  L    D ++K ++    +V D S     FS
Sbjct: 1392 -----KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWS---NKFS 1443

Query: 3021 DWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAME 3080
            +W+ +   A  +    + +V     + EL +    +    +N L++ + +Q   +    +
Sbjct: 1444 EWKKK---AQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRF----D 1496

Query: 3081 CLQ---KADRRSLLSEIQALHAQMNGRKITL--------KREQESEKPSQELLEYNIQQK 3129
            CL+   + D+  +  +   L  ++  +   +        ++  E E  ++ L  YN QQK
Sbjct: 1497 CLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN-QQK 1555

Query: 3130 QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL 3189
              +  E+  +L   ++   E   ++   +  +  L++++   K ELET         KEL
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET-------KKKEL 1608

Query: 3190 EAFRLEVKDKTDEVHLLNDTLASE--------QKKSRELQWALEKE-KAKLGRSEERDKE 3240
            E   L VK K +E+  L D L SE        ++K+ +   A++K+  +++   EE+ K+
Sbjct: 1609 EHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK 1668

Query: 3241 ELEDLKFSLESQ-KQRNLQLNLLLEQQKQLLNE------------------SQQKIESQ- 3280
              E     L ++ ++R  ++++L E+ K + +                    Q++ +SQ 
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728

Query: 3281 --RMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPP 3338
              +  Y+ ++S  Q    E + LL+      +E   T+    E+  Q Q      +    
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVG---QEKEETVSSHFEMRCQYQERLIKLEHAEA 1785

Query: 3339 LPSED--LLKELQKQLEE---KHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3393
               ED  ++  LQ++LEE   K+S IV    E E  K +++Q +Q +E      +KTLQ 
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGK-NNIQAKQNLENVFDDVQKTLQE 1844

Query: 3394 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ---EFQKQELER 3450
            ++      ++K+ EL S    L RQ E  R ++ +L  + ++LQ + Q     +  EL  
Sbjct: 1845 KELTCQILEQKIKELDS---CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901

Query: 3451 EEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNH 3510
            E   E  +    +L +P    L++   ++  L+ K+ G  +E       ++         
Sbjct: 1902 ENTEEKSK---SHLVQPKL--LSNMEAQHNDLEFKLAGAEREKQ-----KLGKEIVRLQK 1951

Query: 3511 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQEN--IDEIILQLQKLTGQQ 3568
            +L M+R++ Q    +L++L ++  +  + +   +++ + ++ N  + +++ +      Q+
Sbjct: 1952 DLRMLRKEHQ---QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008

Query: 3569 GEEPSLVSPST--SCGSLTERLLRQNAELTGHISQLTEEKND------------------ 3608
             +E  +    T      +   LL  + E T  + +   EK+D                  
Sbjct: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068

Query: 3609 -----LRNMVMKLEEQIRWYRQ-----TGAGRDNSSRFSLNGGANIEAIIASE---KEVW 3655
                 +R++  +LEE  + Y+Q        G DN +   L      +  + S+   KE  
Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128

Query: 3656 NREKL-TLQKSLKRAEAEVY 3674
             RE++  L+  LK+ E  VY
Sbjct: 2129 FREQIHNLEDRLKKYEKNVY 2148


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  214 bits (544), Expect = 2e-54
 Identities = 506/2519 (20%), Positives = 1033/2519 (41%), Gaps = 399/2519 (15%)

Query: 542  EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
            EQ+   +Q +AE ++      K+    +  +A +V           K +A+V  Y+   +
Sbjct: 22   EQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVR----------KLQAKVLQYRSWCQ 71

Query: 602  MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI--EHRINIEKLK--- 656
             LEK   A    + +  E   E    +LL   EEE  + +   E+  + R+++EK     
Sbjct: 72   ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVN 131

Query: 657  -------DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI------------- 696
                   + L + + +  D L  + SQ     +F K  L  +  +L+             
Sbjct: 132  KALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191

Query: 697  LEISKLKDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEKGTLEQEVQE------L 748
            LE+    D  + L+  K+E + L  + L     + +  Q  +  G+   + +E      L
Sbjct: 192  LEMKSATD--RDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLL 249

Query: 749  QLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808
              KT+ LEK+  E+  +L +  +Q + E + L+D    L  +L      SQ++   +   
Sbjct: 250  LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALL----TQSQKQNEDYEKM 305

Query: 809  IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868
            IK+        + +EIL   + +L +    L+   ++++ +     K+      E  +  
Sbjct: 306  IKA------LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNI 359

Query: 869  ACLLKVKDDLE-DSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAET 927
            A     ++ LE DS    + +Y+   KAL               +  SV    +  V + 
Sbjct: 360  AQGSGHENSLELDSSIFSQFDYQDADKALT--------------LVRSVLTRRRQAVQDL 405

Query: 928  LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEK 987
             +     ++    L ++ +  + E   L QRL  L+ +     G+   L  EV SL +E+
Sbjct: 406  RQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKER 465

Query: 988  EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK 1047
            E +     EL         + ++  + +   L    V +  +G      K  +   EE  
Sbjct: 466  ELLQKAREELR--------QQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQ--EELH 515

Query: 1048 IMVEDKVSFENMTVGEESKQEQ------LILDHLPSVTKESSLRATQPSEND----KLQK 1097
            + V ++   + M +G E+KQ +       + + L S   E  L   + +E      + ++
Sbjct: 516  LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575

Query: 1098 ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEK---DKALCSLKEE--LIF 1152
             +  L S +N L+ ++   R       +  +  + E +  +K   ++ L  L+EE   + 
Sbjct: 576  SIAELSSSENTLKTEVADLRAA-----AVKLSALNEALALDKVGLNQQLLQLEEENQSVC 630

Query: 1153 AQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGE 1212
            ++ E  ++ +   Q++L   + +      K  H L  +LQKA                  
Sbjct: 631  SRMEAAEQARNALQVDLAEAEKRREALWEKNTH-LEAQLQKAE----------------- 672

Query: 1213 YYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLV 1272
                    E  AE + +  D   E E  E+Q    E +  QE   T L ++ +E  +   
Sbjct: 673  --------EAGAELQADLRDIQEEKE--EIQKKLSESRHQQEAATTQLEQLHQEAKR--- 719

Query: 1273 LQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSK-LSSLQDL 1331
                       Q + +     E+     E   L +  Q    +  D+  + + LSS ++L
Sbjct: 720  -----------QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL 768

Query: 1332 EKTKLEEQVQELESLISSLQQQLK-------ETEQNYEAEIHCLQKRLQAV-SESTVPPS 1383
             ++ L E  Q+  S+I   + QL+       + ++  + E+ CL+  L    S++     
Sbjct: 769  LESSLFE-AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD 827

Query: 1384 LPVDSVVITESDAQRTMYPGSCV-KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442
                 +   E + +  +       +K ++   E   +     +  + K LE   +E++E 
Sbjct: 828  AAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMEL 887

Query: 1443 EVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQT 1502
            E+            QQTE+  I   +E   +  ++ A+CQ        M+L  ++     
Sbjct: 888  EMR--------LKEQQTEMEAIQAQREEERTQAES-ALCQ--------MQLETEKERVSL 930

Query: 1503 FETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVR 1562
             ET+ ++ ++E    S++L     E L  +     + E +   +  ++   ++ +     
Sbjct: 931  LETL-LQTQKELADASQQL-----ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984

Query: 1563 QSIHDEISVSSMDASRQL---MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619
            +   D+++    ++S  L   M  ++Q+ED++ +LV      Q  ++ L +  +++  R+
Sbjct: 985  RQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA-----QDDSQRLVEQEVQEKLRE 1039

Query: 1620 REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
             ++  ++Q+E++R      +++S+    +  E+  ++L+E ++++Q  L           
Sbjct: 1040 TQEYNRIQKELER------EKASLTLSLMEKEQRLLVLQEADSIRQQEL----------- 1082

Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK-----ANNRLLKI 1734
              S   Q+  E QGE +E + + + L ++ ++   + L+ E   L++        + L+ 
Sbjct: 1083 --SALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRA 1140

Query: 1735 LLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDES 1794
             L   +  AA  +   R     L+  +  Q   +        AS+ S + +    V  ES
Sbjct: 1141 SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVC-ES 1199

Query: 1795 IPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV 1854
             P  SG     +  ++W      G E  Q   RS F       +   L+  +S+      
Sbjct: 1200 RPELSGGG--DSAPSVW------GLEPDQNGARSLF-------KRGPLLTALSA------ 1238

Query: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914
                EA++    +L H  + +T+  R+  R +          ++L ERL +    + Q+ 
Sbjct: 1239 ----EAVASALHKL-HQDLWKTQQTRDVLRDQ---------VQKLEERLTDTEAEKSQVH 1284

Query: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974
             EL   +  +    +EK+ +E +       +  L + +    +RL+  E ++ + Q ERE
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344

Query: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK---VRDDLQKQVKALEIDVE 2031
            LL   KE + A           + E L    +E + QA     + +DL+    AL++  E
Sbjct: 1345 LLQAAKENLTA-----------QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393

Query: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091
            E     +E E+E+   L +  +   A  K L++    L +   +RE E +  + +IQ+LE
Sbjct: 1394 E-----VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE 1448

Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151
            +Q           E Q   +E L+  LK++     E+ L +EQ+Q ++++    +E L  
Sbjct: 1449 KQ----------REMQKAALELLSLDLKKRN---QEVDLQQEQIQ-ELEKCRSVLEHLPM 1494

Query: 2152 RVRELEQALLVSADTFQKVE-DRKHFGAVEAKPELSLEVQ---LQAERDAIDRKEKEITN 2207
             V+E EQ L V  +  +++E DR+    V     L LE +   ++++R  +   +K++  
Sbjct: 1495 AVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVT 1554

Query: 2208 LE---EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2264
            LE    +LE+   ++E + + +++L  Q E Q+   T    +LE+ ++    +++     
Sbjct: 1555 LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ----ELQAQSSQ 1610

Query: 2265 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI 2324
            I + ++ ST          A+ +QE++ E+    EQ+ +LQ+Q            K  L 
Sbjct: 1611 IHDLESHST--------VLARELQERDQEVKSQREQIEELQRQ------------KEHLT 1650

Query: 2325 RDLETQIECLMSDQECVKRNREEEIEQ---LNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
            +DLE + + LM  +E ++   ++   Q   L E +E+++  L   G++ +     + E A
Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710

Query: 2382 D-----------SLKHQLDVVIAEKLALEQQVETANE---EMTFMKNVLK---------- 2417
            +           SL+H + +++ +K   E++VE   E   E+  +K+ L+          
Sbjct: 1711 EEGKGPSKAQRGSLEH-MKLILRDK---EKEVECQQEHIHELQELKDQLEQQLQGLHRKV 1766

Query: 2418 -ETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKS 2476
             ET+  ++Q  QE+  L+++ +   +   + E S+   +D   +   + +  L  +AL+ 
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL--EALQQ 1824

Query: 2477 LENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFE---T 2533
             + Q   +  EE  K     L+  L Q   T+  +  EL    +Q + ++E+   E    
Sbjct: 1825 EQQQA--QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRV 1882

Query: 2534 EMLQKKIVNLQKIVEEKVAAALVSQIQ-LEAVQEY---AKFCQDNQTISSEPERTNIQNL 2589
            + L++ + +L+    E+  A L  Q Q  E  QE+    +  QD+   +    +   Q L
Sbjct: 1883 QALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQEL 1942

Query: 2590 NQLREDELGS--DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEK--EKKLLE 2645
              LR +   S     A   R   L+  + + H +  L+ ++  + E+  L +  E     
Sbjct: 1943 EALRAESQSSRHQEEAARARAEALQEALGKAHAA--LQGKEQHLLEQAELSRSLEASTAT 2000

Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL 2705
            LQ  L+  +   R+ E+    Q+ E+          +++  +  +++ L+ +++A + E 
Sbjct: 2001 LQASLDACQAHSRQLEEALRIQEGEI---------QDQDLRYQEDVQQLQ-QALAQRDEE 2050

Query: 2706 ASYKEKAEKLQEELLVK--ETNMTSLQKDLSQVRD-------HLAEAKEKLSILEKEDE- 2755
              ++++ E+L E+ L +  + NM   +++L Q R+       H +  + +L++ +KE E 
Sbjct: 2051 LRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEI 2110

Query: 2756 TEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSE 2815
             E++E+++    E LP   S   +   + +LK+ S     Q  ++       LQ+     
Sbjct: 2111 LELRETQQRNNLEALP--HSHKTSPMEEQSLKLDSLEPRLQRELE------RLQAALRQT 2162

Query: 2816 EVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVI 2875
            E  EI     E  EK Q+L     L +     S +   +   ++   +L+ +    +   
Sbjct: 2163 EAREI-----EWREKAQDL----ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQD 2213

Query: 2876 QCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESES 2934
            +   ++       L    A  T E+     GS   QG+ L    G +      G E +S
Sbjct: 2214 ELELTRRALEKERLHSPGATSTAEL-----GSRGEQGVQLGEVSGVEAEPSPDGMEKQS 2267



 Score =  197 bits (500), Expect = 2e-49
 Identities = 464/2377 (19%), Positives = 966/2377 (40%), Gaps = 372/2377 (15%)

Query: 164  LAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDE 223
            L  K  E+E+   E  +  +   ++G  +  E +  +       T+L+A L Q++++ ++
Sbjct: 249  LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRV-------TELSALLTQSQKQNED 301

Query: 224  TMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHL 283
              +    L E  + L+    +L   E   +         L Q  + I   Q  +EE D++
Sbjct: 302  YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDIT--QVMVEEGDNI 359

Query: 284  LE------------------DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
             +                  DYQ   +  T+  S L  + +     QD + + +     Q
Sbjct: 360  AQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAV---QDLRQQLAG---CQ 413

Query: 326  EKETIIEELNTKIIEEEKKTLELKDKLT-TADKLLGEL------------QEQIVQKNQE 372
            E   ++++ + +  EE K   +   KLT   D L G+             + +++QK +E
Sbjct: 414  EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473

Query: 373  IKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQ 432
                +LE+   +    +      QL G   + QK   ++ Q E  +  R  +  Q  L  
Sbjct: 474  ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQK---EEQQEELHLAVRERERLQEMLMG 530

Query: 433  LRAELDEMYGQQIVQMKQELIRQHMAQ--MEEMKTRHKGEMENALRSYSNITVNEDQIKL 490
            L A+  E   + ++ +++ L   H+    + + +T     +  A +S + ++ +E+ +K 
Sbjct: 531  LEAKQSESLSE-LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589

Query: 491  MNVAINELNIKLQDTNS----QKEKLKEELGLILEEK---CALQRQLEDLVEELSFSREQ 543
                +    +KL   N      K  L ++L  + EE    C+     E     L     +
Sbjct: 590  EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAE 649

Query: 544  IQRARQTIAEQESKLN-EAHKSLSTVEDLKAEIVSASESRKELELK-----HEAEVTNYK 597
             ++ R+ + E+ + L  +  K+     +L+A++    E ++E++ K     H+ E    +
Sbjct: 650  AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709

Query: 598  IK-LEMLEKEKNAVLDRMAESQEAELER-----LRTQLLFSHEEELSKLKEDLEIEHRIN 651
            ++ L    K +  VL R  + +EA +       +R Q +    ++L++  + L      +
Sbjct: 710  LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS-----S 764

Query: 652  IEKLKDNLGIHYKQQ---IDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQS 708
             ++L ++     +QQ   I+  + ++  +I+T+   K+ +  +   L LE+    D ++S
Sbjct: 765  AKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL----DTERS 820

Query: 709  LVNSKSEEMTLQINELQKEIEILRQE-----EKEKGTLEQE--------VQELQLKTELL 755
                + +    Q+ + ++E +   ++     EKE   L ++         QEL    E L
Sbjct: 821  QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESL 880

Query: 756  EKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD 815
            E++  E E  L+E+  ++EA  +  ++E+   E  L      +++ER+  L+++    K+
Sbjct: 881  EREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940

Query: 816  -SVWEKEIEILIEENEDLKQQCIQ-------LNEEIEKQRNTFSFAEKNFEVNYQELQEE 867
             +   +++E L    +D+K Q ++       L  ++++ +     A +    +   LQEE
Sbjct: 941  LADASQQLERL---RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997

Query: 868  YACLLKVKDDL--------------EDSKNKQELEYKSKLKALNEELHLQR-INPTTVKM 912
             + LL+ K DL              +DS+   E E + KL+   E   +Q+ +      +
Sbjct: 998  SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057

Query: 913  KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972
              S+ ++++  +    E   + +++ + L + ++  + E+ ELS ++  L +++K+K  E
Sbjct: 1058 TLSLMEKEQRLLV-LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK--E 1114

Query: 973  ISFLNEEVKSLKQ--------------------EKEQVSLRCR----ELEIIINHNRAEN 1008
              FL +E + L++                    +  Q+ LR R    +LE +    +  N
Sbjct: 1115 ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174

Query: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSV--SKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
                  Q++SL   +     + A GSV  S+   S G +S   V      +N   G  S 
Sbjct: 1175 QAQAQAQLASLYSAL-----QQALGSVCESRPELSGGGDSAPSVWGLEPDQN---GARSL 1226

Query: 1067 QEQLILDHLPSVTKESSLRATQPSEND--KLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124
             ++  L  L +++ E+   A      D  K Q+  +VL+ +   L  ++       S V+
Sbjct: 1227 FKRGPL--LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284

Query: 1125 STHVDQVREYMENEKDKALC-----SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179
            +   D  R+  +N+++K+       SL+ EL+   E       ++ + ELQ M+ Q  G+
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ--GE 1342

Query: 1180 EGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYIS-ENE 1238
                      +L +A  E  +  ++ L + + E    A    +  ED   +   +  +NE
Sbjct: 1343 R---------ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393

Query: 1239 DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL--VLQTRLSKIWGQQTDGMKLEFGEEN 1296
            + E +  R +    Q  +     K  +E   LL   L  R  ++   +    +LE  +  
Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE-KQRE 1452

Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK-----LEEQVQELESLISSLQ 1351
            + K   E LS+  +  N +++D+  +     +Q+LEK +     L   VQE E  ++  +
Sbjct: 1453 MQKAALELLSLDLKKRN-QEVDLQQE----QIQELEKCRSVLEHLPMAVQEREQKLTVQR 1507

Query: 1352 QQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNID 1411
            +Q++E E++ E + + L+ +L  + +        ++S      D ++ +    C+   ++
Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKK----DQMIESQRGQVQDLKKQLVTLECLALELE 1563

Query: 1412 GTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENT 1471
                      ++ +  ++K LE Q + Q    VA   +++ +    Q          E  
Sbjct: 1564 -----ENHHKMECQQKLIKELEGQRETQ---RVALTHLTLDLEERSQ----------ELQ 1605

Query: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLS 1531
            A S Q H +         E++    ++  Q  +  +++ ++E   L+++L    +E++L 
Sbjct: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEH--LTQDLERRDQELML- 1662

Query: 1532 NSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMR 1591
                      K+ +  + ++   + K  I+ + + ++I +S  +  R+L    + +++  
Sbjct: 1663 ---------QKERIQVLEDQRTRQTK--ILEEDL-EQIKLSLRERGRELTTQRQLMQERA 1710

Query: 1592 QE------LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL--AQRSSI 1643
            +E        R   EH    +L+ +   +++E Q+E   +LQE   +L +QL    R   
Sbjct: 1711 EEGKGPSKAQRGSLEHM---KLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767

Query: 1644 DNENLVSERER---VLLEELEALKQLSLAGREKLCCEL---------RNSSTQTQNGNEN 1691
            +   L+S+RE+   VL ++L+  ++      + L  +L         R+   +     + 
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYA-LQKANNRLLKILLEVV---KTTAAVEE 1747
            Q + +E+  KEK    +       +   ER+  LQ    +  ++  E+    +   A+EE
Sbjct: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887

Query: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807
                 VLG L   S+ Q  A L  + +     +   HE  TR   +S             
Sbjct: 1888 -----VLGDLRAESREQEKALLALQQQCAEQAQE--HEVETRALQDS------------- 1927

Query: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ 1867
               W +      E  Q L                              + L A S++S  
Sbjct: 1928 ---WLQAQAVLKERDQEL------------------------------EALRAESQSSRH 1954

Query: 1868 LEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGY 1927
             E A   + E ++E+  +   A +  +      + L E++    +L+  L  +   +   
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKE------QHLLEQA----ELSRSLEASTATLQAS 2004

Query: 1928 ADEKTLFERQIQEKTDIIDR--LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985
             D      RQ++E   I +    +Q+L    +  Q  +A  Q+ +E R    R++   K+
Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064

Query: 1986 EAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDV---EEQVSRFIELEQ 2042
             A  V++ ++QE + L +E+ E     E++R  L + V+ L++ +   E+++    E +Q
Sbjct: 2065 LAQRVQENMIQEKQNLGQEREE-----EEIR-GLHQSVRELQLTLAQKEQEILELRETQQ 2118

Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102
              N E +    +   +E+Q  K+               D  +  +Q+  ++L+   R   
Sbjct: 2119 RNNLEALPHSHKTSPMEEQSLKL---------------DSLEPRLQRELERLQAALRQTE 2163

Query: 2103 ISEHQTRE-VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161
              E + RE  + LA  L +     S L      LQ  + ER+ E ++L+  +    +AL 
Sbjct: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL- 2222

Query: 2162 VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2221
                     ++R H     +  EL    +   +   +   E E +    + + +R+ LE+
Sbjct: 2223 --------EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEH 2274

Query: 2222 KNEEVQQLHM---QLEIQKKESTTRLQELEQENKLFKDDMEKL----GLAIKESDAMS-- 2272
              + V +L +   +L+    +  + L+++E+E +  K +  +      L I ++ A S  
Sbjct: 2275 LQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPT 2334

Query: 2273 TQDQHVLFGKFAQIIQEKEVEIDQLNEQVT--KLQQQLKITTDNKVIEEKNELIRDLETQ 2330
             QD        A+ + E + E+  L  Q+T  + Q+Q  IT   +   E   L   L   
Sbjct: 2335 QQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHS 2394

Query: 2331 IECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2367
            +  +    E      E E  +L+   E L Q L + G
Sbjct: 2395 LLAVAQAPEATV--LEAETRRLD---ESLTQSLTSPG 2426



 Score =  191 bits (485), Expect = 1e-47
 Identities = 494/2349 (21%), Positives = 931/2349 (39%), Gaps = 391/2349 (16%)

Query: 1324 KLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPS 1383
            +L S  DLEK +L+++V EL +L++  Q+Q     ++YE  I  L+              
Sbjct: 269  QLKSQGDLEKAELQDRVTELSALLTQSQKQ----NEDYEKMIKALR-------------- 310

Query: 1384 LPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEE 1443
               ++V I E++    M   + + +N                       EK   +Q+ ++
Sbjct: 311  ---ETVEILETNHTELMEHEASLSRNAQE--------------------EKLSLQQVIKD 347

Query: 1444 VAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTF 1503
            + +V+V      AQ         G EN+          + +   F++             
Sbjct: 348  ITQVMVEEGDNIAQ-------GSGHENSL---------ELDSSIFSQFDYQDADKALTLV 391

Query: 1504 ETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQ 1563
             +V  + ++  + L ++L    + + L     HD  E +   L    +  + ++  +  Q
Sbjct: 392  RSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ-HDQWEEEGKALRQRLQKLTGERDTLAGQ 450

Query: 1564 SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE----HQQATELLRQAHMRQMERQ 1619
            ++  +  V S+   R+L+  ++  E++RQ+L    QE     +   EL  Q    Q +++
Sbjct: 451  TVDLQGEVDSLSKERELL--QKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKE 508

Query: 1620 REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
             E QE+L   ++   R+  Q   +  E   SE    L+   EAL+   L G E L  E  
Sbjct: 509  -EQQEELHLAVRE--RERLQEMLMGLEAKQSESLSELITLREALESSHLEG-ELLRQEQT 564

Query: 1680 NSSTQTQNGNENQGEVE--EQTFKEKELDRKPEDVPPEILSNERYALQKA--NNRLLKIL 1735
              +       ++  E+   E T K +  D +   V    L NE  AL K   N +LL++ 
Sbjct: 565  EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL-NEALALDKVGLNQQLLQLE 623

Query: 1736 LE---VVKTTAAVEETIGRHVLGILDRSSKSQS--------SASLIWRSEAEASVKSCVH 1784
             E   V     A E+      + + +   + ++         A L    EA A +++ + 
Sbjct: 624  EENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLR 683

Query: 1785 ------EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE----GTELSQRLVRSGFAGT- 1833
                  EE  +   ES      +      ++  +K  EE      +  + LVR   A   
Sbjct: 684  DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEV 743

Query: 1834 ---EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVT--QTELMRESFRQKQE 1888
                ++ + ++L   +   L +A E L  ++ E   Q    +VT  Q E+  ++  Q +E
Sbjct: 744  RLQAVERDRQDLAEQLQG-LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKE 802

Query: 1889 ATES-LKCQE-ELRERLHEESRAREQLAVELSKAEGV-IDGYADEKTLFERQI------- 1938
              +  ++C + EL     +  + R+  A +L++AE         +K   E+++       
Sbjct: 803  VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKW 862

Query: 1939 --------QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
                    QE    ++ LE+E +    RL+E + E + IQ +RE     +E  +AE+   
Sbjct: 863  EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE-----EERTQAESALC 917

Query: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
            + QL  ETEK     LE   Q +K   D  +Q++ L  D++ Q  +  E      T+L +
Sbjct: 918  QMQL--ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQE 975

Query: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
             +++ +   +Q       L E++     ++   Q++++ L+ QL          +   R 
Sbjct: 976  AQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA-------QDDSQRL 1028

Query: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV--SADTFQ 2168
            VEQ          +  E L   ++  R  +E   E   L   + E EQ LLV   AD+ +
Sbjct: 1029 VEQ----------EVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078

Query: 2169 KVE-DRKHFGAVEAKPE-LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEV 2226
            + E         EA+ E   L  Q++  R  +  KE +    E QL    EELE  +   
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL---LEELEASHITE 1135

Query: 2227 QQLH----------MQLEIQKKESTTRLQELEQENK-------------LFKDDMEKLGL 2263
            QQL            QL+++ + + ++L+ L  E +             L+    + LG 
Sbjct: 1136 QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195

Query: 2264 AIKESDAMS------------TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2311
              +    +S              DQ+     F +      +  + +   + KL Q L  T
Sbjct: 1196 VCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKT 1255

Query: 2312 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN-IGQKT 2370
                  ++  +++RD   ++E  ++D E  K     E++ L   + + Q+E +   G++ 
Sbjct: 1256 ------QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN 1309

Query: 2371 SMNAH--SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
            S+ +    L E   SL+ +L      + A  Q++E   E     + +L+     +    +
Sbjct: 1310 SLESELMELHETMASLQSRL------RRAELQRMEAQGE-----RELLQAAKENLTAQVE 1358

Query: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2488
             L +   E  +      I E  +  A   L     E+E     +  ++L+ Q   K  + 
Sbjct: 1359 HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVE--SERERAQALQEQGELKVAQ- 1415

Query: 2489 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
             GK     L+  L  L  T++ ++ E+     QI+++++Q + +   L+   ++L+K  +
Sbjct: 1416 -GKA----LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQ 1470

Query: 2549 EKVAAALVSQIQLEAVQEYAKFCQD-----NQTISSEPERTNIQNLNQLREDELGSDISA 2603
            E         +Q E +QE  K C+         +    ++  +Q   Q+RE E   +   
Sbjct: 1471 E-------VDLQQEQIQELEK-CRSVLEHLPMAVQEREQKLTVQR-EQIRELEKDRETQR 1521

Query: 2604 LTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQK---LLEGNEKKQ 2657
                 + LE Q++E+      +  ++ QV+  +K ++  E   LEL++    +E  +K  
Sbjct: 1522 -----NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLI 1576

Query: 2658 REKEKKRSPQDVEVLKTTTELFHSNEE-SGFFNELEALRAESVATKAELASYKEKAEKLQ 2716
            +E E +R  Q V +   T +L   ++E     +++  L + S     EL    ++ +  +
Sbjct: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQR 1636

Query: 2717 EELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILE--KEDETEVQESKKACMFEPLPIKL 2774
            E++   +     L +DL +    L   KE++ +LE  +  +T++ E       E + + L
Sbjct: 1637 EQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED----LEQIKLSL 1692

Query: 2775 ---SKSIASQTDGTLKISSSNQTPQILVKNAGIQINL-------QSECSSEEVTEIISQF 2824
                + + +Q     + +   + P    + +   + L       + EC  E + E+    
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK 1752

Query: 2825 TEKIEKMQELHAAEILDMESRHISETETL--KREHYVAV--QLLKE--ECGTLKAVIQCL 2878
             +  +++Q LH         R + ET  L  +RE  + V  Q L+E  E G LK   Q L
Sbjct: 1753 DQLEQQLQGLH---------RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE--QSL 1801

Query: 2879 RSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ----------------GIYLT----HS 2918
            +S+   +   LA  D  Q  E    +     GQ                  ++T    H 
Sbjct: 1802 QSQLDEAQRALAQRD--QELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG 1859

Query: 2919 QGFDIASEGRGEESESATD----SFPKKIKGLLRAVHNEGMQ-VLSLTESPYSDGEDHSI 2973
            +  D   + R  E E A +       +++ G LRA   E  + +L+L +      ++H +
Sbjct: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919

Query: 2974 Q--QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQ 3031
            +   + + WL+ +         L+ L  + Q  R  E    +++ E+  +  G+   ALQ
Sbjct: 1920 ETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARA-EALQEALGKAHAALQ 1978

Query: 3032 ---QVFLEERSVLLAAFRTELTALGTTDAV--------GLLNCLEQRIQEQGVEYQAAME 3080
               Q  LE+  +  +   +  T   + DA           L   E  IQ+Q + YQ  ++
Sbjct: 1979 GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQ 2038

Query: 3081 CLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKP-SQELLEYNIQQKQSQMLEM-QV 3138
             LQ+A    L    + L  Q        +REQ  EK  +Q + E  IQ+KQ+   E  + 
Sbjct: 2039 QLQQA----LAQRDEELRHQQ-------EREQLLEKSLAQRVQENMIQEKQNLGQEREEE 2087

Query: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK-HLKELEAFRLEVK 3197
            E+  +     ELQ  L+ ++  + EL+    +  LE    L   HK    E ++ +L+  
Sbjct: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLE---ALPHSHKTSPMEEQSLKLDSL 2144

Query: 3198 DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ--R 3255
            +   +  L     A  Q ++RE++W                +E+ +DL  SL   K    
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEW----------------REKAQDLALSLAQTKASVS 2188

Query: 3256 NLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSST 3315
            +LQ   +  Q   L  +S+Q    QR+  + +L+            LE E++     +ST
Sbjct: 2189 SLQEVAMFLQASVLERDSEQ----QRLQDELELTRR---------ALEKERLHSPGATST 2235

Query: 3316 LDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3375
             +        +Q  + +G    P P     +  +++LE     +  L  +  + +  ++Q
Sbjct: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295

Query: 3376 TR---QQMEKDR----------------QVHRKTLQTEQEANTEGQKK-----MHELQSK 3411
             R   +Q+E++R                ++ + T  +  + +  GQK      + ELQ +
Sbjct: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355

Query: 3412 VEDLQRQ--LEEKRQQVY--KLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQ--NLN 3465
            V  LQ Q  LE K++Q Y  +     + L G+        L   +  E+  +  +   L+
Sbjct: 2356 VVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLD 2415

Query: 3466 EPTTWSLTS 3474
            E  T SLTS
Sbjct: 2416 ESLTQSLTS 2424



 Score =  173 bits (438), Expect = 3e-42
 Identities = 396/1958 (20%), Positives = 803/1958 (41%), Gaps = 307/1958 (15%)

Query: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870
            W +  E+  E +   +   +   E +P  +EL++ +    Q       E+++E ++QL  
Sbjct: 69   WCQELEKRLEATGGPIPQRWENVE-EPNLDELLVRLEEEQQRC-----ESLAEVNTQLR- 121

Query: 1871 AKVTQTELMRESFRQKQE--ATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA 1928
              + + +++ ++ R+  E    +  + ++EL  +  +    +E     L    G +    
Sbjct: 122  LHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLW 181

Query: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRL---------------QELEAEQQQIQEER 1973
             E   F R   E     DR   EL     RL               Q  E       + R
Sbjct: 182  REVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGR 241

Query: 1974 E-----LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQ----------CQAEKVRDD 2018
            E     LL  + + ++ EA    Q+L+Q   +   EK E+Q           Q++K  +D
Sbjct: 242  EPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED 301

Query: 2019 LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID--- 2075
             +K +KAL   VE   +   EL + + +   + +++  +L++ ++ + + + E+  +   
Sbjct: 302  YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361

Query: 2076 -------REHERDVF----------------------QQEIQKLEQQL----KVVPRFQP 2102
                    E +  +F                      +Q +Q L QQL    + V   Q 
Sbjct: 362  GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ 421

Query: 2103 ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162
              +    E + L   L++ T +   L      LQ ++   ++E E L+    EL Q L V
Sbjct: 422  QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481

Query: 2163 SADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE-- 2220
                  ++              +++E+QLQ +            + + Q E+ +EEL   
Sbjct: 482  LEQEAWRLR------------RVNVELQLQGD------------SAQGQKEEQQEELHLA 517

Query: 2221 -NKNEEVQQLHMQLEIQKKESTTRLQELEQ-------ENKLFKDDMEKLGLAI---KESD 2269
              + E +Q++ M LE ++ ES + L  L +       E +L + +  ++  A+   ++S 
Sbjct: 518  VRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSI 577

Query: 2270 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNE-----QVTKLQQQLKITTDNKVIEEKNELI 2324
            A  +  ++ L  + A + +   V++  LNE     +V   QQ L++  +N+ +  + E  
Sbjct: 578  AELSSSENTLKTEVADL-RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAA 636

Query: 2325 RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSL 2384
                  ++  +++ E     R E + + N  +E   Q+    G +   +   + EE + +
Sbjct: 637  EQARNALQVDLAEAE----KRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692

Query: 2385 KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE-KI 2443
            + +L     ++ A   Q+E  ++E    + VL           QE  +L RE+ ++E ++
Sbjct: 693  QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARA-------VQEKEALVREKAALEVRL 745

Query: 2444 QSIPENSVNVA--IDHLSKDKPELEVVLTE-----DALKSLENQTYFKSFEENGKGSIIN 2496
            Q++  +  ++A  +  LS  K  LE  L E       ++  + Q   +         +I 
Sbjct: 746  QAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805

Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
             E R L+LE      D E +Q  +Q +D   +   + E   K  +  QK   EK    L 
Sbjct: 806  GEVRCLKLEL-----DTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLR 859

Query: 2557 SQIQLEAV---QEYAKFCQDNQTISSEPE------RTNIQNLNQLREDELGSDISALTLR 2607
             + + E     QE AK  +  +    E E      +T ++ +   RE+E     SAL   
Sbjct: 860  EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919

Query: 2608 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ 2667
              E E + V +  +L+  ++++  A +  LE+ ++ +++QKL      K++E       Q
Sbjct: 920  QLETEKERVSLLETLLQTQKELADASQQ-LERLRQDMKVQKL------KEQETTGILQTQ 972

Query: 2668 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2727
              E  +   E    + +     +L AL+ ES +   +    +++ E L+ +L+ ++ +  
Sbjct: 973  LQEAQRELKEAARQHRD-----DLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027

Query: 2728 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLK 2787
             ++++   V++ L E +E  + ++KE E E     KA +   L  K  + +  Q   +++
Sbjct: 1028 LVEQE---VQEKLRETQE-YNRIQKELERE-----KASLTLSLMEKEQRLLVLQEADSIR 1078

Query: 2788 ISSSNQTPQILVKNAGIQ--INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR 2845
                +   Q + +  G Q  ++ Q E   +EV E  + F  +  ++ E       ++E+ 
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE-------ELEAS 1131

Query: 2846 HISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDS 2905
            HI+E +       +   L  +E    +  ++ LRS E S +  LA       +    +  
Sbjct: 1132 HITEQQ-------LRASLWAQEAKAAQLQLR-LRSTE-SQLEALAAEQQPGNQAQAQAQL 1182

Query: 2906 GSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGL------LRAVHNEGMQVLS 2959
             S     +Y    Q      E R E S    DS P  + GL       R++   G  + +
Sbjct: 1183 AS-----LYSALQQALGSVCESRPELSGGG-DSAPS-VWGLEPDQNGARSLFKRGPLLTA 1235

Query: 2960 LTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQRE---AEVYDS---- 3012
            L+    +    H + Q      + R    + +  L++ +T  + ++     E+ D     
Sbjct: 1236 LSAEAVASAL-HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQL 1294

Query: 3013 SQSHESFSDWRGEL------LLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQ 3066
            SQ+ E  S W G+       L+ L +     +S L  A    + A G  +   LL   ++
Sbjct: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE---LLQAAKE 1351

Query: 3067 RIQEQGVEYQAAM-ECLQKADRRSLLSE-IQALHAQMNGRKITLKREQESEKPSQELLEY 3124
             +  Q    QAA+ E   +A    +L E ++   + +  +   ++ E+E  +  QE  E 
Sbjct: 1352 NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGEL 1411

Query: 3125 NIQQKQS----------QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE 3174
             + Q ++           + E + E+ +++ +  EL++Q   +K  +  L  +L +   E
Sbjct: 1412 KVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQE 1471

Query: 3175 LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQW-------ALEKE 3227
            ++     Q + ++ELE  R  ++     V      L  ++++ REL+         LE +
Sbjct: 1472 VDL----QQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ 1527

Query: 3228 KAKLGRSE---ERDKEELEDLKFSLESQKQRNLQL---NLLLEQQKQLLNESQQKIESQR 3281
              +L + +   E  + +++DLK  L + +   L+L   +  +E Q++L+ E + + E+QR
Sbjct: 1528 LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR 1587

Query: 3282 MLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL------DRERELHAQLQSSDGTGQS 3335
            +       + + R+ ELQ   +S ++   E  ST+      +R++E+ +Q +  +   + 
Sbjct: 1588 VALTHLTLDLEERSQELQA--QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQ 1645

Query: 3336 RPPLPSE--------DLLKELQKQLEEKHSRIVELLNET-EKYKLDSLQTRQQMEKDRQV 3386
            +  L  +         L KE  + LE++ +R  ++L E  E+ KL   +  +++   RQ+
Sbjct: 1646 KEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQL 1705

Query: 3387 --------------------HRKTLQTEQEANTEGQKK-MHELQSKVEDLQRQLEEKRQQ 3425
                                H K +  ++E   E Q++ +HELQ   + L++QL+   ++
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765

Query: 3426 VYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3484
            V +   L  QR Q I+   Q+ +  RE+     + L   L+E        D+    + Q+
Sbjct: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825

Query: 3485 KIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADD 3544
            + + + +E    +  +   G       LE     L+    +LQ   ++A  RL+ E A +
Sbjct: 1826 QQQAQGQEERVKEKADALQGA------LEQAHMTLKERHGELQDHKEQA-RRLEEELAVE 1878

Query: 3545 EDFIWVQENI-----------DEIILQLQKLTGQQGEE 3571
               +   E +           ++ +L LQ+   +Q +E
Sbjct: 1879 GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916



 Score =  145 bits (366), Expect = 8e-34
 Identities = 280/1392 (20%), Positives = 590/1392 (42%), Gaps = 194/1392 (13%)

Query: 158  EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
            E  E E +  Q E+ +    LE  ++       +Q  E EA   QR+   TQ  + L Q 
Sbjct: 860  EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919

Query: 218  RREKDETMREFL--------ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQ 269
            + E ++     L        EL + SQ+L+   Q ++  +     T       L +A+++
Sbjct: 920  QLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE 979

Query: 270  I----LTHQQQL----EEQDHLLE---DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVEN 318
            +      H+  L    EE   LL+   D QK+ ED   Q+    +  ++ E E  +K+  
Sbjct: 980  LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039

Query: 319  SNKEEIQEKETIIEE--LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376
            + +    +KE   E+  L   ++E+E++ L L++  +   + L  L++ + +   E K +
Sbjct: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099

Query: 377  --KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI---------VQRMEQE 425
              ++EL   + KE++ ++ + Q    +EEL+  +  + Q    +         +Q   + 
Sbjct: 1100 SAQMELLRQEVKEKE-ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158

Query: 426  TQRKLEQLRAEL---DEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 482
            T+ +LE L AE    ++   Q  +      ++Q +  + E +    G  ++A   +    
Sbjct: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG--- 1215

Query: 483  VNEDQ-----------------IKLMNVAINELNIKLQDT-------NSQKEKLKEELGL 518
            +  DQ                  + +  A+++L+  L  T         Q +KL+E L  
Sbjct: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275

Query: 519  ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED-LKAEIVS 577
               EK  +  +L+DL  +LS ++E+  +        ES+L E H+++++++  L+   + 
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335

Query: 578  ASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ-----EAELERLRTQLLFS 632
              E++ E EL   A+  N   ++E L+    AV++  A++      E +L   R+ L   
Sbjct: 1336 RMEAQGERELLQAAK-ENLTAQVEHLQA---AVVEARAQASAAGILEEDLRTARSALKLK 1391

Query: 633  HEEELSKLKEDLEIEHRINI-----EKLKDNLGI------HYKQQIDGLQNEMSQKIETM 681
            +EE  S+ +    ++ +  +     + L++NL +        +++++ L+ ++ +  +  
Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451

Query: 682  QFEKDNL-------------ITKQNQLILEISKLKDLQQSL---VNSKSEEMTLQINELQ 725
            + +K  L             +  Q + I E+ K + + + L   V  + +++T+Q  +++
Sbjct: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511

Query: 726  KEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-------------DLQEKFAQ 772
               E+ +  E ++  LE ++ EL+ K +++E Q  + ++             +L+E   +
Sbjct: 1512 ---ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568

Query: 773  LEAENSILK--DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830
            +E +  ++K  + ++  + +   H  +  EER   L +  S+  D   E    +L  E +
Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD--LESHSTVLARELQ 1626

Query: 831  DLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE--LQEEYACLLKVKDDLEDSKNKQELE 888
            +  Q+     E+IE+ +       ++ E   QE  LQ+E   +L+ +   +    +++LE
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686

Query: 889  -YKSKLKALNEELHLQR--------INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939
              K  L+    EL  QR              K +    +  K  + +  +  E  ++   
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746

Query: 940  ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEI 999
            EL E  +  +++   L +++ + S  L Q+  EI  L ++   L++ +EQ  L+ + L+ 
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ---LQEAREQGELKEQSLQ- 1802

Query: 1000 IINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENM 1059
                ++ +  Q    Q    L+  +    + A+G   +V     +E    ++  +   +M
Sbjct: 1803 ----SQLDEAQRALAQRDQELE-ALQQEQQQAQGQEERV-----KEKADALQGALEQAHM 1852

Query: 1060 TVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC 1119
            T+ E   + Q   DH     KE + R  +  E     + +  L+    DLR +   Q   
Sbjct: 1853 TLKERHGELQ---DH-----KEQARRLEE--ELAVEGRRVQALEEVLGDLRAESREQEKA 1902

Query: 1120 LSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ---EEKIKELQKIHQLELQTMKTQE 1176
            L  +     +Q +E+    +     +L++  + AQ   +E+ +EL+ + + E Q+ + QE
Sbjct: 1903 LLALQQQCAEQAQEHEVETR-----ALQDSWLQAQAVLKERDQELEAL-RAESQSSRHQE 1956

Query: 1177 TGDEGK--PLHLLIGKLQKAVSEECSYFL-QTLCSVLGEYYTPALKCEVNA-EDKENSGD 1232
                 +   L   +GK   A+  +  + L Q   S   E  T  L+  ++A +      +
Sbjct: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE 2016

Query: 1233 YISENEDPELQD----YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGM 1288
                 ++ E+QD    Y+ +VQ  Q+ +     ++  +  +  +L+  L++   +     
Sbjct: 2017 EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE 2076

Query: 1289 KLEFGEE------------------NLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSL 1328
            K   G+E                   L ++E E L +    Q  NLE +  +HK+     
Sbjct: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136

Query: 1329 QDLEKTKLEEQVQ-ELESLISSLQQ-QLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPV 1386
            Q L+   LE ++Q ELE L ++L+Q + +E E   +A+   L       S S++      
Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196

Query: 1387 DSVVITESDAQR 1398
                + E D+++
Sbjct: 2197 LQASVLERDSEQ 2208



 Score =  139 bits (349), Expect = 7e-32
 Identities = 182/914 (19%), Positives = 400/914 (43%), Gaps = 91/914 (9%)

Query: 126  RTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTY 185
            +T +  ++LR++   +++  ++  A+ S  H E+ + +         +L++  EE     
Sbjct: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQ--------RQLSQNQEEKSKWE 1305

Query: 186  GTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQL 245
            G +        E+ + +    +  L + L++A  ++ E   E   L    + L  Q + L
Sbjct: 1306 GKQ-----NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHL 1360

Query: 246  QASETLRNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
            QA+     +  S+      DL  A+  +    +++E +    +  Q++ E    Q   LQ
Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420

Query: 303  EKIKVYEM---EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359
            E + +      E++++VE + + +IQE E   E     +   E  +L+LK +    D   
Sbjct: 1421 ENLALLTQTLAEREEEVE-TLRGQIQELEKQREMQKAAL---ELLSLDLKKRNQEVDLQQ 1476

Query: 360  GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419
             ++QE + +    ++++ + +   +QK     E+I++L            KD + + +++
Sbjct: 1477 EQIQE-LEKCRSVLEHLPMAVQEREQKLTVQREQIREL-----------EKDRETQRNVL 1524

Query: 420  QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYS 479
            +    E ++K + + ++       Q+  +K++L+      +E  +  HK E +  L    
Sbjct: 1525 EHQLLELEKKDQMIESQRG-----QVQDLKKQLVTLECLALELEENHHKMECQQKL---- 1575

Query: 480  NITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSF 539
             I   E Q +   VA+  L + L++ + + +    ++  +      L R+L++  +E+  
Sbjct: 1576 -IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634

Query: 540  SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599
             REQI+  ++        L    + L   ++ + +++    +R+   L+ + E    +IK
Sbjct: 1635 QREQIEELQRQKEHLTQDLERRDQELMLQKE-RIQVLEDQRTRQTKILEEDLE----QIK 1689

Query: 600  LEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE------IEHRINIE 653
            L + E+ +     R    + AE  +  ++      E +  +  D E       EH   ++
Sbjct: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749

Query: 654  KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
            +LKD L    +QQ+ GL  ++ +    +   +  ++  Q QL  E  +  +L++  + S+
Sbjct: 1750 ELKDQL----EQQLQGLHRKVGETSLLLSQREQEIVVLQQQL-QEAREQGELKEQSLQSQ 1804

Query: 714  SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE----LQLKTELLEKQMKEKENDLQ-- 767
             +E    + +  +E+E L+QE+++    E+ V+E    LQ   E     +KE+  +LQ  
Sbjct: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864

Query: 768  -EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI 826
             E+  +LE E ++     + LE++L      S+E+    L +++ +  +   E E+E   
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL-ALQQQCAEQAQEHEVETRA 1923

Query: 827  EENEDLKQQCI---------QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL-KVKD 876
             ++  L+ Q +          L  E +  R+    A    E   + L + +A L  K + 
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983

Query: 877  DLEDSKNKQELEYK-SKLKALNE--ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV 933
             LE ++  + LE   + L+A  +  + H +++       +  + D+D  +  +  ++ + 
Sbjct: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043

Query: 934  VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG------EISFLNEEVKSLK--- 984
            + +   EL  + E  +  +  L+QR+ +   Q KQ  G      EI  L++ V+ L+   
Sbjct: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103

Query: 985  QEKEQVSLRCRELE 998
             +KEQ  L  RE +
Sbjct: 2104 AQKEQEILELRETQ 2117



 Score = 61.2 bits (147), Expect = 2e-08
 Identities = 129/644 (20%), Positives = 261/644 (40%), Gaps = 70/644 (10%)

Query: 4    EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63
            +E Q+ L     +L   +Q + Q+ GQ    K+K      + +    AH  L     +  
Sbjct: 1806 DEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE---QAHMTLKERHGELQ 1862

Query: 64   EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
            + +   ++R+E  +  E   ++ L   E+    +  S E E  +      C+ +      
Sbjct: 1863 D-HKEQARRLEEELAVEGRRVQALE--EVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919

Query: 124  VMRTGKPTNLLREEEFGVDDSYSEQGA--QDSPTHLEMMESELAGKQHEIEELNRELEEM 181
              R              + DS+ +  A  ++    LE + +E    +H+ E      E +
Sbjct: 1920 ETR-------------ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEAL 1966

Query: 182  RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
            +   G +    LQ  E  + ++  +   L A+    +   D       +L E    L+IQ
Sbjct: 1967 QEALG-KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQ 2022

Query: 242  FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFL 301
              ++Q  + LR           L  + + L HQQ   E++ LLE    ++    +Q + +
Sbjct: 2023 EGEIQ-DQDLRYQEDVQQLQQALAQRDEELRHQQ---EREQLLEKSLAQR----VQENMI 2074

Query: 302  QEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361
            QEK     + Q+++     +EEI+     + EL   + ++E++ LEL++  T     L  
Sbjct: 2075 QEK---QNLGQERE-----EEEIRGLHQSVRELQLTLAQKEQEILELRE--TQQRNNLEA 2124

Query: 362  LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421
            L         E +++KL+       E +   E+++L   + + + R  +  +   D+   
Sbjct: 2125 LPHSHKTSPMEEQSLKLD-----SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179

Query: 422  MEQETQRKLEQLR--------AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMEN 473
            + Q T+  +  L+        + L+    QQ +Q + EL R+    +E+ +    G    
Sbjct: 2180 LAQ-TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR---ALEKERLHSPGATST 2235

Query: 474  A-LRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR---Q 529
            A L S     V   ++  +    +   ++ Q    + E L++ +  +  ++  LQR   Q
Sbjct: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295

Query: 530  LEDLVEELSFSREQIQRARQTIAEQES-KLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
            L   +E++   R +++R     A+  S ++++A  S  T +D + +  S ++   EL   
Sbjct: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAEL--- 2352

Query: 589  HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS 632
             + EV   + +L +  K+K   + R A++   EL  L   L  S
Sbjct: 2353 -QKEVVLLQAQLTLERKQKQDYITRSAQTSR-ELAGLHHSLSHS 2394



 Score = 59.7 bits (143), Expect = 6e-08
 Identities = 137/677 (20%), Positives = 273/677 (40%), Gaps = 93/677 (13%)

Query: 3082 LQKAD--RRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
            ++KAD   ++L  +++ L    +  +  L R++   +  QE  +  ++ +  ++L +  E
Sbjct: 124  MEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWRE 183

Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET-----TLKAQHKHLKELEAFRL 3194
            + + +    E++     + M   ELK+E  +    L T     T+ AQ +      + R+
Sbjct: 184  VVTFRRHFLEMKSATDRDLM---ELKAEHVRLSGSLLTCCLRLTVGAQSREPNG--SGRM 238

Query: 3195 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3254
            + ++    + LL  T   E++     Q     E  +L    + +K EL+D    L +   
Sbjct: 239  DGREPAQLLLLLAKTQELEKEAHERSQ-----ELIQLKSQGDLEKAELQDRVTELSALLT 293

Query: 3255 RNLQLNLLLEQQKQLLNESQQKIESQR---MLYDAQLSEE-QGRNLELQ-VLLESEKVRI 3309
            ++ + N   E+  + L E+ + +E+     M ++A LS   Q   L LQ V+ +  +V +
Sbjct: 294  QSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMV 353

Query: 3310 RE---------MSSTLDRERELHAQLQSSDG----TGQSRPPLPSEDLLKELQKQLEEKH 3356
             E           ++L+ +  + +Q    D     T            +++L++QL    
Sbjct: 354  EEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ 413

Query: 3357 SRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQ 3416
              +  L  + ++++ +    RQ+++K     R TL  +     + Q ++  L  + E LQ
Sbjct: 414  EAVNLLQQQHDQWEEEGKALRQRLQK-LTGERDTLAGQ---TVDLQGEVDSLSKERELLQ 469

Query: 3417 RQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ-ELEREEKRESRRILYQNLNEPTTWSLTSD 3475
            +  EE RQQ+  L+ E  RL+ +  E Q Q +  + +K E +  L+  + E         
Sbjct: 470  KAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE--------- 520

Query: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3535
            R R   +   +E +  ES  ++LI +       + E E++RQ+   V + L    Q  +E
Sbjct: 521  RERLQEMLMGLEAKQSES-LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579

Query: 3536 ------RLQFETAD-----------DEDFIWVQENIDEIILQLQK--------------- 3563
                   L+ E AD           +E     +  +++ +LQL++               
Sbjct: 580  LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639

Query: 3564 -------LTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3616
                   L   +    +L   +T   +  ++     AEL   +  + EEK +++    KL
Sbjct: 640  RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQK---KL 696

Query: 3617 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKL 3676
             E  R  ++    +             + A    EKE   REK  L+  L+  E +   L
Sbjct: 697  SES-RHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755

Query: 3677 KAELRNDSLLQTLSPDS 3693
              +L+  S  + L   S
Sbjct: 756  AEQLQGLSSAKELLESS 772



 Score = 51.6 bits (122), Expect = 2e-05
 Identities = 128/681 (18%), Positives = 271/681 (39%), Gaps = 130/681 (19%)

Query: 3119 QELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKL---EL 3175
            Q +LE  +   Q QM E Q         + E Q++ ++   +V +L++++ Q +    EL
Sbjct: 17   QLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQAT---LVRKLQAKVLQYRSWCQEL 73

Query: 3176 ETTLKA------------QHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3223
            E  L+A            +  +L EL     E + + + +  +N  L    +K+  +  A
Sbjct: 74   EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133

Query: 3224 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3283
            L ++  KL     R ++EL  ++   + Q ++      L  +  +LL+  ++ +  +R  
Sbjct: 134  LREDVEKLTVDWSRARDEL--MRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191

Query: 3284 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3343
             + + + +  R+L   + L++E VR+     T      + AQ +  +G+G+     P++ 
Sbjct: 192  LEMKSATD--RDL---MELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQL 246

Query: 3344 LL-----KELQKQLEEKHSRIVELLNETEKYK---------LDSLQTRQQMEKD------ 3383
            LL     +EL+K+  E+   +++L ++ +  K         L +L T+ Q + +      
Sbjct: 247  LLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMI 306

Query: 3384 ----------RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEG 3433
                         H + ++ E   +   Q++   LQ  ++D+ + + E+   + +     
Sbjct: 307  KALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366

Query: 3434 QRLQ---GIMQEFQKQELERE---------EKRESRRILYQNL-----------NEPTTW 3470
              L+    I  +F  Q+ ++           +R++ + L Q L            +   W
Sbjct: 367  NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQW 426

Query: 3471 SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLP 3530
                   R  +  QK+ GE +++   + +++ G     + E E++++  + +  +L+VL 
Sbjct: 427  EEEGKALRQRL--QKLTGE-RDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483

Query: 3531 QKA---------------SERLQFETADDEDFIWVQEN--IDEIILQLQKLTGQQGEEPS 3573
            Q+A               S + Q E   +E  + V+E   + E+++ L+    +   E  
Sbjct: 484  QEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI 543

Query: 3574 LVSPSTSCGSLTERLLRQN---------------AELTGHISQLTEEKNDLRNMVMKLEE 3618
             +  +     L   LLRQ                AEL+   + L  E  DLR   +KL  
Sbjct: 544  TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603

Query: 3619 -----------------QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLT 3661
                             Q+    Q+   R  ++  + N      A     +E    +   
Sbjct: 604  LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663

Query: 3662 LQKSLKRAEAEVYKLKAELRN 3682
            L+  L++AE    +L+A+LR+
Sbjct: 664  LEAQLQKAEEAGAELQADLRD 684


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  199 bits (507), Expect = 3e-50
 Identities = 402/1998 (20%), Positives = 816/1998 (40%), Gaps = 259/1998 (12%)

Query: 215  QQARREKDETMREFLELTEQSQKLQI--QFQQLQASETLRNSTHSSTAADLLQAKQQILT 272
            Q+ R+++ E  RE  E  EQS+K +   Q  + +  E L          +  +A+++ L 
Sbjct: 135  QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194

Query: 273  HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIE 332
              +  E ++   E+  +++E   ++    +EK +     QD+  +   ++E +++ET++ 
Sbjct: 195  SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254

Query: 333  ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
            +   K+ EEE +                ELQE+   + Q  K  + EL   +Q+E Q  +
Sbjct: 255  KEEEKLQEEEPQRQR-------------ELQEE---EEQLRKLERQELRRERQEEEQQQQ 298

Query: 393  EIK--QLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450
             ++  Q +   +E ++R  ++ + E    +R EQ+ +R+ +QLR E +E   QQ+ + ++
Sbjct: 299  RLRREQQLRRKQEEERREQQEERREQQ--ERREQQEERREQQLRREQEERREQQLRREQE 356

Query: 451  ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE 510
            E  R+   + E+ + R + ++             E Q++       E  ++ +    +++
Sbjct: 357  EERREQQLRREQEEERREQQLRR-----------EQQLRREQQLRREQQLRREQQLRREQ 405

Query: 511  KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED 570
            +L+ E  L  E++   ++QL    EE    ++  Q  R+   ++E +  E    L   E+
Sbjct: 406  QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE--ERRDWLKREEE 463

Query: 571  LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLL 630
             +       + R++ +LK + E    +  L++ E+E+    +R  +    E E  R Q L
Sbjct: 464  TERH----EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519

Query: 631  FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEM-SQKIETMQFEKDNLI 689
               EEE  +L++ L  E ++  E+ +    +  +++   L+ E   Q+++  Q E+ + +
Sbjct: 520  KRQEEE-ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578

Query: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQ 749
             K+ +        +  QQ L   + E +  ++   ++E+E L QEE+ +  L++E  E +
Sbjct: 579  LKREE--------ERRQQRLKREQEERLEQRLK--REEVERLEQEERREQRLKREEPEEE 628

Query: 750  LKTELLEKQMKEKENDLQEKFAQLEAENSILK--DEKKTLEDMLKIH-------TPVSQE 800
             + +LL+ + +E+    Q +  Q E     LK  +E++ LE  LK           +++E
Sbjct: 629  RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688

Query: 801  ERLIFLDSIKSKSKDSVWEKEIEILIEENE----DLKQQCIQLNEEIEKQRNTFSFAEKN 856
            E+    + IKS+     W+ E E    +++      KQ+  +  +E E++R       + 
Sbjct: 689  EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR-----RRE 743

Query: 857  FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSV 916
             E+ +QE +  +      +   E+ +     +++++ K+      L    P   + +  +
Sbjct: 744  SELQWQEEERAHR-----QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL 798

Query: 917  FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFL 976
              E++             +++   L E+ E  +R +            Q +++  E+ FL
Sbjct: 799  RAEERQ------------QREQRFLPEEEEKEQRRR------------QRREREKELQFL 834

Query: 977  NEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVS 1036
             EE +  ++E+ Q  L+  E  +  +  R  + +    Q             R    +  
Sbjct: 835  EEEEQLQRRERAQ-QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893

Query: 1037 KVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQ 1096
             + +   +E +++ E++   +     +  +QEQ                  Q  E ++LQ
Sbjct: 894  ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ----------------ERQYREEEQLQ 937

Query: 1097 KELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEE 1156
            +E   L  E+ + R + E +R                  +  KDK L   +E+L+  + E
Sbjct: 938  QEEEQLLREEREKRRRQERER------------------QYRKDKKLQQKEEQLLGEEPE 979

Query: 1157 KIK--ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYY 1214
            K +  E +K ++ E +  + +E         LL  + +K   +E     +          
Sbjct: 980  KRRRQEREKKYREEEELQQEEE--------QLLREEREKRRRQEWERQYRK--------- 1022

Query: 1215 TPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKL-LVL 1273
                K E+  E+++   +   +    E +    E ++ Q+    LL +  E   +  L  
Sbjct: 1023 ----KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078

Query: 1274 QTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK 1333
            Q R  +   Q+ + +  E  E+   +E         ++   E+  +  + +    Q+LE+
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138

Query: 1334 TKLEEQV--QELESLISSLQQQLK--ETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSV 1389
               EE+   QE E L+    ++ +  E E+ Y  E    Q+  Q + E         +  
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198

Query: 1390 VITESDAQRTM----YPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVA 1445
               E + QR      Y     + ++    E   E  V++     K  E +   QLE+   
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL 1258

Query: 1446 KVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFET 1505
            +   S       Q +L  + G ++     ++     Q+++H+  E +L +++   +  + 
Sbjct: 1259 RDRQS-------QQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ--KEAKR 1309

Query: 1506 VDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSI 1565
             D K +EE + L +E  E  +             +  D      E++  + +   +R+  
Sbjct: 1310 RDRKSQEEKQLLREEREEKRRR------------QETDRKFREEEQLLQEREEQPLRRQE 1357

Query: 1566 HD----EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQRE 1621
             D    E  +   +  R+ +  E++L   RQE  R++ + +Q    LR     Q  RQ  
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLR--RQERERKFLKEEQQ---LRCQEREQQLRQDR 1412

Query: 1622 DQEQLQEEIKRLNRQLAQRSSIDNENLV--SERERVLLEELEALKQ---LSLAGREKLCC 1676
            D++  +EE ++L+RQ   R   + E  V   ERER  LEE + L+Q         E+L  
Sbjct: 1413 DRK-FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471

Query: 1677 ELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANN-----RL 1731
            E        Q  +    E EEQ  + +E DRK  +        ER  L++        R 
Sbjct: 1472 EREEQQLHRQERDRKFLE-EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530

Query: 1732 LKILLEVVKTTAAVEETIGRHVLGIL---DRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788
             K L E        E+ + R   G     DR  K +    L  R E E    S    +  
Sbjct: 1531 RKFLQE--------EQQLRRQERGQQRRQDRDRKFREEEQL--RQEREEQQLSRQERDRK 1580

Query: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848
               +E        +    +     +  E   +L Q   R      ++  E EE  L+   
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640

Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
            R +  +E+          QL   +  Q +L  +  R+ +E  + L+  EE + R  E  R
Sbjct: 1641 RDRKFLEE--------EPQLRRQEREQ-QLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691

Query: 1909 AREQLAVELSKAEGVIDGYADEKTL----FERQIQEKTDIIDRLEQELLCASNRLQEL-- 1962
               +   +L + E       +E+ L     ER+ +E+  +    EQE L    R +++  
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751

Query: 1963 ------EAEQQQIQ-EERELLSRQKEAMKAEAGPVEQQL--------LQETEKLMKEKLE 2007
                  E E+QQ++ +ER+   R++E ++ E    EQQL         +E E+L +E+ E
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQERE--EQQLRSQESDRKFREEEQLRQEREE 1809

Query: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRK 2067
             Q + ++     + + + L+++ +EQ      L QE++ +     +Q    EK   + ++
Sbjct: 1810 QQLRPQQRDGKYRWEEEQLQLEEQEQ-----RLRQERDRQYR-AEEQFATQEKSRREEQE 1863

Query: 2068 FLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
               E+   R  ER+   +E + + +Q K   R + + E +++E +     L+  T + + 
Sbjct: 1864 LWQEEEQKRRQERERKLRE-EHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFAS 1922

Query: 2128 LLLSKEQLQRDIQERNEE 2145
            + +    L   IQE+  +
Sbjct: 1923 VPVRSSPLYEYIQEQRSQ 1940



 Score =  193 bits (491), Expect = 2e-48
 Identities = 422/1998 (21%), Positives = 793/1998 (39%), Gaps = 225/1998 (11%)

Query: 1567 DEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER--QREDQE 1624
            DE   +  D    L+ +  Q ED R+   R  Q  ++  +  RQ    Q     + E+Q 
Sbjct: 96   DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155

Query: 1625 QLQEEIKRLNRQLAQRSSIDNENLVSERE--RVLLEELEALK---------QLSLAGREK 1673
            + QE +++ +RQ              ERE  R   E+L++ K         +  L  RE 
Sbjct: 156  EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215

Query: 1674 LCCELRNSSTQTQNGNENQGEV----EEQTFKEKE-LDRKPEDVPPEILSNERYALQKAN 1728
            L    +    + Q   E Q  V    EE+ ++++E + RK E+   E     +  LQ+  
Sbjct: 216  LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275

Query: 1729 NRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788
             +L K+  + ++     EE   +     L R  + +       R + E   +     E  
Sbjct: 276  EQLRKLERQELRRERQEEEQQQQR----LRREQQLRRKQEEERREQQEERREQQERREQQ 331

Query: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848
                E           R +  +  +  EE  E  Q+L R      E + E  E  L    
Sbjct: 332  EERREQ--QLRREQEERREQQLRREQEEERRE--QQLRR------EQEEERREQQLRREQ 381

Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
            +L+   +   E       QL   +  + E   +  R++Q+     + + E  E  HE+  
Sbjct: 382  QLRREQQLRREQQLRREQQLRREQQLRRE---QQLRREQQLRREQQLRREQEEERHEQKH 438

Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
             +E+    L + +     +   +   ER  QE+     + +QE       L+  E E+++
Sbjct: 439  EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498

Query: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI 2028
             QE R                 EQQL +E E+  +++L+ Q + E+++  L+ + + L  
Sbjct: 499  QQERR-----------------EQQLRREQEERREQRLKRQEEEERLQQRLRSE-QQLRR 540

Query: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQ 2088
            + EE+  + ++ E+EK    ++  ++ Q L+++ E+ R  L ++  +R  +R   +QE +
Sbjct: 541  EQEERREQLLKREEEKR---LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE-E 596

Query: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE-------QLQRDIQE 2141
            +LEQ+LK   R +     Q    EQ     + + ++  +LL S+E       QL+R+ QE
Sbjct: 597  RLEQRLK---REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653

Query: 2142 RNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEV---QLQAERDAI 2198
            R E+  K E     LEQ L    +  ++ ++       +A+  +   +   Q Q E +A 
Sbjct: 654  RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713

Query: 2199 DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDM 2258
             R+ K  +   +Q  Q R   + + E+ ++   +L+ Q++E   R Q+ E++ + F    
Sbjct: 714  ARQSKVYSRPRKQEGQRRR--QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771

Query: 2259 EKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIE 2318
            +    + +    +S +           + +++E ++     Q    Q++ +   + +  E
Sbjct: 772  QAEEKSERGRQRLSAR---------PPLREQRERQLRAEERQ----QREQRFLPEEEEKE 818

Query: 2319 EKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN-AHSL 2377
            ++    R+ E +++ L  +++  +R R +++++  + +++ Q+   +  Q+        L
Sbjct: 819  QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878

Query: 2378 SEEADSLKHQL--DVVIAEKLALEQQV------ETANEEMTFMKNVLKETNFK-MNQLTQ 2428
             EE    +H L     + E+L  EQQ+      E   EE    +   +E  ++   QL Q
Sbjct: 879  EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938

Query: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2488
            E   L RE     + Q   E       D   + K E  +    +  +  E +  ++  EE
Sbjct: 939  EEEQLLREEREKRRRQ---ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE 995

Query: 2489 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
                  +  E   L  E     +  E  + Y++  ++Q+    E E L ++    +++ E
Sbjct: 996  ------LQQEEEQLLREEREKRRRQEWERQYRKKDELQQ----EEEQLLREEREKRRLQE 1045

Query: 2549 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL-NQLREDELGSDISALTLR 2607
             +       ++Q E          + Q +  E E    Q L  Q R++E           
Sbjct: 1046 RERQYREEEELQQE----------EEQLLGEERETRRRQELERQYRKEE----------E 1085

Query: 2608 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL-EGNEKKQREKEKKRSP 2666
            + + E Q++        EK + +  E+   E+E+   E ++LL E  EK++R++ +++  
Sbjct: 1086 LQQEEEQLLREEP----EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 2667 QDVEVLKTTTELFHSNEESGFFNELE-ALRAESVATKAELASYKEKAEKLQE--ELLVKE 2723
            ++ EV +   +L     E     ELE   R E    + E    +E+ EK ++  E   +E
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201

Query: 2724 TNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTD 2783
                  QK   + RD    +  K    E E E  V+++K  C       + ++      D
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQ-WEPEKENAVRDNKVYCKG-----RENEQFRQLED 1255

Query: 2784 GTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDME 2843
              L+   S Q  Q L+   G Q     E       +    F E  E+  E    +     
Sbjct: 1256 SQLRDRQSQQDLQHLL---GEQQERDREQERRRWQQRDRHFPE--EEQLEREEQKEAKRR 1310

Query: 2844 SRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSS 2903
             R   E + L RE     +  +E     +   Q L+ +E   +        ++  E+   
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370

Query: 2904 DSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTES 2963
            + G       +L   Q        R +E E     F K+ +  LR    E  Q+    + 
Sbjct: 1371 EQGRK-----FLEEEQRL------RRQERER---KFLKE-EQQLRCQERE-QQLRQDRDR 1414

Query: 2964 PYSDGEDH-SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDW 3022
             + + E   S Q+    + EE +         K L  + QL++E   +   +  E     
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER--HRKFREEEQLLQE 1472

Query: 3023 RGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECL 3082
            R E     QQ+  +ER      F  E   L   +        E R QE   ++    + L
Sbjct: 1473 REE-----QQLHRQERD---RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524

Query: 3083 QKADR-RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141
             +  R R  L E Q L  Q  G++    R+++  +  Q   E   QQ   Q  + +  L 
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLE 1584

Query: 3142 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK------------AQHKHLKEL 3189
              K R  E + +   ++    +L+ +  Q +L  E   K             Q  H +E 
Sbjct: 1585 EQKVRRQEQERKFMEDEQ---QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641

Query: 3190 EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD---KEELEDL- 3245
            +   LE + +               +K RE +  L++ + +  R +ERD   +EE + L 
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR 1701

Query: 3246 ------KFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR-NLEL 3298
                  KF  E Q+ R  +L     +++QL  E++Q+   ++  Y   L EEQ R   E 
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE 1761

Query: 3299 QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSR 3358
            Q L   E+ R       L +ERE   QL+S +   + R     E L +E ++Q      R
Sbjct: 1762 QQLRRQERDRKFREEEQLRQERE-EQQLRSQESDRKFR---EEEQLRQEREEQQLRPQQR 1817

Query: 3359 IVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQ 3418
              +   E E+ +L+  + R + E+DRQ      + E++  T+ + +  E     ++L ++
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQERDRQ-----YRAEEQFATQEKSRREE-----QELWQE 1867

Query: 3419 LEEKRQQVYKLDLEGQRLQGIMQEFQKQ----ELEREEKRESRRILYQNLNEPTTWSLTS 3474
             E+KR+Q  +  L  + ++   +E Q+     E++ +E +   R+L     EP T    S
Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLL-----EPGTHQFAS 1922

Query: 3475 DRTRNWVLQQKIEGETKE 3492
               R+  L + I+ +  +
Sbjct: 1923 VPVRSSPLYEYIQEQRSQ 1940



 Score =  172 bits (436), Expect = 6e-42
 Identities = 371/1845 (20%), Positives = 762/1845 (41%), Gaps = 222/1845 (12%)

Query: 167  KQHEIEEL-------NRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
            K HE EE         REL E+R     E  QQ +E +  + Q +    +        R+
Sbjct: 197  KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE-KEWRKRETVLRK 255

Query: 220  EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQ---- 275
            E+++   E  +   + Q+ + Q ++L+  E  R           L+ +QQ+   Q+    
Sbjct: 256  EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315

Query: 276  -QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
             Q EE+    E  ++++E    Q+   QE+ +  ++ ++++ E   ++  +E+E   EE 
Sbjct: 316  EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE---EER 372

Query: 335  NTKIIEEEKKTLELKDKLTTADKLLGELQ---EQIVQKNQEIKNMKLELTNSKQKERQSS 391
              + +  E++ L  + +L    +L  E Q   EQ +++ Q+++  + +L   +Q  R+  
Sbjct: 373  REQQLRREQQ-LRREQQLRREQQLRREQQLRREQQLRREQQLRREQ-QLRREQQLRREQE 430

Query: 392  EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQ----ETQRKLEQLRAELDEMYGQQIVQ 447
            EE  +     E  ++R  ++ +   D ++R E+    E +R+ +QL+ + +E   ++ ++
Sbjct: 431  EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490

Query: 448  MKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
            +++E  R+   + E+   R + E     R    +   E++ +L     +E  ++ +    
Sbjct: 491  LEEEERREQQERREQQLRREQEE-----RREQRLKRQEEEERLQQRLRSEQQLRREQEER 545

Query: 508  QKEKLKEELGLILEE---KCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKS 564
            +++ LK E    LE+   +  L+R+ E+  ++L   RE+ +R ++   EQE +L +  K 
Sbjct: 546  REQLLKREEEKRLEQERREQRLKREQEERRDQL-LKREEERRQQRLKREQEERLEQRLK- 603

Query: 565  LSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELER 624
                             R+E+E   + E    ++K E  E+E+   L +  E +E   ++
Sbjct: 604  -----------------REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646

Query: 625  LRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFE 684
            LR +     E+ L + +E+  +E R+  E  ++      +++ +  + E  Q  E +   
Sbjct: 647  LRREQQERREQRLKREEEEERLEQRLKREHEEE------RREQELAEEEQEQARERI--- 697

Query: 685  KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE-----EKEKG 739
            K  +   Q QL  E     D +QS V S+  +   Q    ++E +  R+E     ++E+ 
Sbjct: 698  KSRIPKWQWQLESE----ADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753

Query: 740  TLEQEVQELQLKTELLEKQMKEKENDLQEKFA-----------QLEAENSILKDEKKTLE 788
               Q+ +E Q +    + Q +EK    +++ +           QL AE    ++++   E
Sbjct: 754  AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813

Query: 789  DMLKIHTPVSQEER---LIFL---DSIKSKSKDSVWEKEIEILIEENEDLKQQ------- 835
            +  K      + ER   L FL   + ++ + +    ++E + L E+ E  + Q       
Sbjct: 814  EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873

Query: 836  -CIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDS------KNKQELE 888
               QL EE +++R+T  +A+   +   ++L++E   L + +++L+        + +QE +
Sbjct: 874  WRWQLEEERKRRRHTL-YAKPALQ---EQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929

Query: 889  YKSKLKALNEE---LHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945
            Y+ + +   EE   L  +R      + +     + K    E   +GE  EK   +  EK 
Sbjct: 930  YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK- 988

Query: 946  EVTKREKLELSQRLSDL--SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH 1003
                RE+ EL Q    L   E+ K++  E      +   L+QE+EQ+    RE   +   
Sbjct: 989  --KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046

Query: 1004 NRAENVQSCDTQVSSLLDGVVTMTSR--GAEGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061
             R    +    Q    L G    T R    E    K  +   EE +++ E+         
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106

Query: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLS 1121
              + ++E+ +      + +E   +  +     + ++E  V + E+  LR + E +R    
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR---- 1162

Query: 1122 LVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK---IKELQKIHQLELQTMK-TQET 1177
                   +  R+Y E E+   L   +E+L+  ++EK    +E Q   + ELQ  K  Q  
Sbjct: 1163 -----RQELERQYREEEE---LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214

Query: 1178 GDEGKPLHL---LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKEN-SGDY 1233
             DE +   L      + + AV +   Y          +     L+   + +D ++  G+ 
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274

Query: 1234 ISENEDPELQDYRYEVQDFQENMHTLLNKVTE--------EYNKLLVLQTRLSKIWGQQT 1285
               + + E + ++   + F E       +  E        +  K L+ + R  K   Q+T
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334

Query: 1286 DGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELES 1345
            D  K    E+ L + E + L    +     + ++ H+ +     + E+ +L  Q +E + 
Sbjct: 1335 D-RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE-EEQRLRRQERERKF 1392

Query: 1346 LISSLQQQLKETEQNYEAE-IHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGS 1404
            L    Q + +E EQ    +     ++  Q +S          +   +   + +R      
Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452

Query: 1405 CVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRI 1464
               +  +   +F  E  + +E    +L  ++   +  EE  ++         ++ EL   
Sbjct: 1453 QQLRQ-ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511

Query: 1465 SGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEH 1524
               ++     +Q H   +Q +    E +L + + G Q  +  D KF+EE     ++L + 
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE-----EQLRQE 1566

Query: 1525 GKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE 1584
             +E  LS  +                    +D+ F +     +E  V   +  R+ M +E
Sbjct: 1567 REEQQLSRQE--------------------RDRKFRL-----EEQKVRRQEQERKFMEDE 1601

Query: 1585 EQL------EDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638
            +QL      + +RQE  R+++E +Q   LL++   +Q+ RQ  D++ L+EE +   ++  
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQ---LLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658

Query: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ-TQNGNENQGEVEE 1697
            Q+   D +    E E++L E  E  +QL    R++   + R    Q  +   E +   EE
Sbjct: 1659 QQLRHDRDRKFREEEQLLQEGEE--QQLRRQERDR---KFREEEQQLRRQERERKFLQEE 1713

Query: 1698 QTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGIL 1757
            Q  + +EL+RK  +        E+  L++   R  KIL E        E+ + R      
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRR-QERYRKILEEEQLRPEREEQQLRRQ----- 1767

Query: 1758 DRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE 1817
            +R  K +    L  R E E               ++ + S       R +  +  +  E+
Sbjct: 1768 ERDRKFREEEQL--RQERE---------------EQQLRSQESDRKFREEEQLRQEREEQ 1810

Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
                 QR  +  +   ++  E +E       RL+   ++   A  + ++Q E ++  + E
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQE------QRLRQERDRQYRAEEQFATQ-EKSRREEQE 1863

Query: 1878 LMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEG 1922
            L +E  +++++  E    +E +R +  EE R R+   ++  + +G
Sbjct: 1864 LWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKG 1908



 Score =  169 bits (429), Expect = 4e-41
 Identities = 360/1767 (20%), Positives = 719/1767 (40%), Gaps = 187/1767 (10%)

Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609
            E++   ++  + R+   +E     +   +QL   +E+    +QE  R+ QE ++  E  R
Sbjct: 276  EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335

Query: 1610 QAHM-RQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSL 1668
            +  + R+ E +RE Q + ++E +R  +QL +    +       RE+ L  E +  ++  L
Sbjct: 336  EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395

Query: 1669 AGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN 1728
               ++L         + Q   E Q   E+Q  +E++L R+ E+   E    +++  ++  
Sbjct: 396  RREQQL-------RREQQLRREQQLRREQQLRREQQLRREQEEERHE----QKHEQERRE 444

Query: 1729 NRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788
             RL +   E        EET         +R  + +    L    E E   +    EE  
Sbjct: 445  QRLKREQEERRDWLKREEET---------ERHEQERRKQQLKRDQEEERRERWLKLEEEE 495

Query: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848
            R   +                   K  EE   L QRL        E +   E+L+     
Sbjct: 496  RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555

Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
            +      +      E   + +     + E  ++  +++QE     + + E  ERL +E R
Sbjct: 556  KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615

Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
              ++L  E  + E        E+    RQ Q + +  +R EQ L     R +E E  +Q+
Sbjct: 616  REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRL----KREEEEERLEQR 671

Query: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA--------------EK 2014
            ++ E E   R++E  + E     +++     K  + +LE +  A              ++
Sbjct: 672  LKREHEEERREQELAEEEQEQARERIKSRIPK-WQWQLESEADARQSKVYSRPRKQEGQR 730

Query: 2015 VRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAI 2074
             R + +++ +  E +++ Q       +Q++  +  D   Q QA EK     ++      +
Sbjct: 731  RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790

Query: 2075 DREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 2134
              + ER +  +E Q+ EQ      RF P  E    E EQ     +E+ +K  + L  +EQ
Sbjct: 791  REQRERQLRAEERQQREQ------RFLPEEE----EKEQRRRQRRER-EKELQFLEEEEQ 839

Query: 2135 LQR-----DIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEV 2189
            LQR      +QE  + +++ + R R  EQ          + E ++    + AKP L  ++
Sbjct: 840  LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899

Query: 2190 Q-----LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2244
            +     LQ E + + R+E+E    +EQ  Q+REE + + EE Q L  + E  K+    R 
Sbjct: 900  RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE--KRRRQERE 957

Query: 2245 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2304
            ++  ++ KL + + + LG   +E +    Q++   + +  ++ QE+E  + +  E+  + 
Sbjct: 958  RQYRKDKKLQQKEEQLLG---EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014

Query: 2305 QQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELA 2364
            + + +    +++ +E+ +L+R            +E  KR  +E   Q  E  E+LQQE  
Sbjct: 1015 EWERQYRKKDELQQEEEQLLR------------EEREKRRLQERERQYREE-EELQQEEE 1061

Query: 2365 NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424
             +          L EE ++ + Q          LE+Q     E     + +L+E   K  
Sbjct: 1062 QL----------LGEERETRRRQ---------ELERQYRKEEELQQEEEQLLREEPEKRR 1102

Query: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484
            +        +RER+  E+ +   E    +  +   + + ELE    E+     E +   +
Sbjct: 1103 R-------QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155

Query: 2485 SFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2544
              EE  K     LE +  + E     ++  L +  ++ +  +E+   E E LQ++    Q
Sbjct: 1156 --EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ-KRKQ 1212

Query: 2545 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL--NQLREDELGSDIS 2602
            +  +E   + L  + Q E  +E A   +DN+      E    + L  +QLR+ +   D+ 
Sbjct: 1213 RYRDEDQRSDL--KWQWEPEKENA--VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ 1268

Query: 2603 AL----TLRISELESQVVEMHTSLILEKEQVEIAE-KNVLEKEKKLLELQKLL--EGNEK 2655
             L      R  E E +  +       E+EQ+E  E K    +++K  E ++LL  E  EK
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328

Query: 2656 KQREKEKKRSPQDVEVLKTTTEL-FHSNEESGFFNELEALRAESVATKAELASYKEKAEK 2714
            ++R++  ++  ++ ++L+   E      E    F E E LR +    K      + + ++
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE-EELRHQEQGRKFLEEEQRLRRQE 1387

Query: 2715 LQEELLVKETNMTSLQKD--LSQVRDH-LAEAKEKLSILE-----KEDETEVQESKKACM 2766
             + + L +E  +   +++  L Q RD    E +++LS  E     +E+E +V+  ++   
Sbjct: 1388 RERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447

Query: 2767 FEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS--EEVTEIISQF 2824
            F     +L +          +     +  Q+L +    Q++ Q       EE  ++  Q 
Sbjct: 1448 FLEEEQQLRQE---------RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498

Query: 2825 TEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGS 2884
             ++  + QEL + E    E + + E + L R+     + L+EE        Q LR +E  
Sbjct: 1499 RDRKFREQELRSQE---PERKFLEEEQQLHRQQRQR-KFLQEE--------QQLRRQERG 1546

Query: 2885 SIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG-RGEESESATDSFPKKI 2943
                      ++  E    +      Q       + F +  +  R +E E       +++
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQ--QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604

Query: 2944 KGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQL 3003
            +        EG Q L          ++  +Q+  E  L  ++         K L  + QL
Sbjct: 1605 R------RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE------RDRKFLEEEPQL 1652

Query: 3004 QREAEVYDSSQSHESFSDWRGELLLAL----QQVFLEERSVLLAAFRTELTALGTTDAVG 3059
            +R+    +    H+    +R E  L      QQ+  +ER      FR E   L   +   
Sbjct: 1653 RRQER--EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD---RKFREEEQQLRRQERER 1707

Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ 3119
                 EQ+++ Q +E +      ++ ++    +E + L  Q   RKI  + +   E+  Q
Sbjct: 1708 KFLQEEQQLRRQELERK-----FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762

Query: 3120 ELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTL 3179
            +L      +K  +  +++ E    + R+ E   +   E+ +  E + +  + + + +   
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ-QRDGKY 1821

Query: 3180 KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDK 3239
            + + + L +LE     ++ + D  +   +  A+++K  RE Q   ++E+ K  R +ER++
Sbjct: 1822 RWEEEQL-QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK--RRQERER 1878

Query: 3240 EELEDLKFSLESQKQRNLQLNLLLEQQ 3266
            +  E+     + ++QR+ Q+  +  Q+
Sbjct: 1879 KLREEHIRRQQKEEQRHRQVGEIKSQE 1905



 Score =  169 bits (427), Expect = 6e-41
 Identities = 393/1952 (20%), Positives = 803/1952 (41%), Gaps = 223/1952 (11%)

Query: 767  QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI 826
            +EK A+ + + S+L+D ++  ED  +      Q E     +    + +    E+E E+  
Sbjct: 97   EEKRARCDGKESLLQDRRQE-EDQRRFEPRDRQLE-----EEPGQRRRQKRQEQERELAE 150

Query: 827  EENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQE 886
             E +  KQ+ +   E+ ++QR       +  E  +QE +E  A     ++ L+  K  + 
Sbjct: 151  GEEQSEKQERL---EQRDRQRRDEELWRQRQE--WQEREERRA----EEEQLQSCKGHET 201

Query: 887  LEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
             E+  + +    EL   R      K +     +D+ F  E  E  E  +++T  L ++ E
Sbjct: 202  EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE--EEKEWRKRETV-LRKEEE 258

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRA 1006
              + E+ +  + L +  EQL++         +E++  +QE+EQ   R R  + +      
Sbjct: 259  KLQEEEPQRQRELQEEEEQLRKLE------RQELRRERQEEEQQQQRLRREQQLRRKQEE 312

Query: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
            E  +  + +                E    +  +    E +   E ++  E     EE +
Sbjct: 313  ERREQQEERREQ---------QERREQQEERREQQLRREQEERREQQLRREQ----EEER 359

Query: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126
            +EQ +        +E  LR  Q     +L++E  + + +Q  LR + + +R         
Sbjct: 360  REQQLRREQEEERREQQLRREQ-----QLRREQQLRREQQ--LRREQQLRR--------- 403

Query: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
               Q+R   +  +++ L   +E+ +  ++E+ +  QK H+ E +  + +   +E +    
Sbjct: 404  -EQQLRREQQLRREQQL--RREQQLRREQEEERHEQK-HEQERREQRLKREQEERRDWLK 459

Query: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
               + ++   E     L+             L+ E   E +E     +   E  E ++ R
Sbjct: 460  REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL-RREQEERREQR 518

Query: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306
             + Q+ +E +   L   +E+  +    + R   +  ++   ++ E  E+ L +E+ E   
Sbjct: 519  LKRQEEEERLQQRLR--SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER-- 574

Query: 1307 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIH 1366
               Q+   E+     + K    + LE+    E+V+ LE      +Q+LK  E   E    
Sbjct: 575  -RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE-ERREQRLKREEPEEERRQQ 632

Query: 1367 CLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEET 1426
             L+   Q   E      L  +     E   +R        ++ ++  ++   E    EE 
Sbjct: 633  LLKSEEQ---EERRQQQLRREQQERREQRLKREEE-----EERLEQRLKREHE----EER 680

Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQH 1486
               +L E++ QEQ  E +   I         + +  +    K  +   KQ     +QEQ 
Sbjct: 681  REQELAEEE-QEQARERIKSRIPKWQWQLESEADARQ---SKVYSRPRKQEGQRRRQEQE 736

Query: 1487 YFNEMKLSQDQIGFQTFETVDVKFKEE-------FKPLSKELGEHGKEILLSNSDPHDIP 1539
               + +  + ++ +Q  E    + +EE       ++  ++E  E G++ L +      + 
Sbjct: 737  --EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP---LR 791

Query: 1540 ESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQ 1599
            E ++  L  +EE   +++ F+  +   ++      +  ++L   EE+ +  R+E  +Q Q
Sbjct: 792  EQRERQLR-AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850

Query: 1600 EHQQATELLRQAHMRQMERQREDQE---QLQEEIKRLNRQLAQRSSIDNENLVSERERVL 1656
            E +    L      R+ + QR DQ+   QL+EE KR    L  + ++  +     +E+ L
Sbjct: 851  EEEDG--LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ---LRKEQQL 905

Query: 1657 LEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI 1716
            L+E E  ++L    REK     R    +     E   + EEQ  +E+   R+ ++   + 
Sbjct: 906  LQEEE--EELQREEREK---RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960

Query: 1717 LSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAE 1776
              +++  LQ+   +LL             EE   R      +R  K +    L  + E E
Sbjct: 961  RKDKK--LQQKEEQLLG------------EEPEKRRRQ---EREKKYREEEEL--QQEEE 1001

Query: 1777 ASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEID 1836
              ++    E   R   E    Y   D  + +     +   E   L +R  R      E+ 
Sbjct: 1002 QLLRE---EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER-ERQYREEEELQ 1057

Query: 1837 PENEELM-LNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKC 1895
             E E+L+     +R +  +E+      E   + E     + E  R   R++Q   E  + 
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ-CREEEEL 1116

Query: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
            Q+E  + L EE   R +  +E    E             E ++Q++ + + R E E    
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYRE-------------EEEVQQEEEQLLREEPE---- 1159

Query: 1956 SNRLQELEA---EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA 2012
              R QELE    E++++Q+E E L R+++  + +     ++  +E E+L ++K + + + 
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQE---RERQYREEEELQRQKRKQRYRD 1216

Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIE-LEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
            E  R DL+ Q +  + +       + +  E E+  +L D + +++  ++ L+ +    ++
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG--EQ 1274

Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131
            Q  DRE ER  +QQ             R  P  E   RE ++ A     K+ +  +LL  
Sbjct: 1275 QERDREQERRRWQQR-----------DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE 1323

Query: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQL 2191
            + + +R  QE + +  + E  ++E E+  L   +  +K  + +     + +  L  E +L
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL 1383

Query: 2192 QA-ERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2250
            +  ER+    KE++    +E+ +Q R++ + K  E +Q   QL  Q+++   R    E+E
Sbjct: 1384 RRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ---QLSRQERDRKFR----EEE 1436

Query: 2251 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK-LQQQLK 2309
             ++ + + E+  L   E +    Q++H  F +  Q++QE+E +     E+  K L+++ +
Sbjct: 1437 QQVRRQERERKFL---EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493

Query: 2310 ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQK 2369
            +    +  + + + +R  E + + L  +Q+  ++ R+ +  Q  + + + ++     GQ+
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER-----GQQ 1548

Query: 2370 TSMNAHSLSEEADSLKHQLDVVIAE------KLALEQQ-VETANEEMTFMKN-------- 2414
               +      E + L+ + +           K  LE+Q V    +E  FM++        
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608

Query: 2415 ----VLKETNFKMN---QLTQE-----LFSLKRERESVEKIQSIPENSVNVAIDHLSKDK 2462
                + +E + K     QL QE     L   +R+R+ +E+   +        + H  +D+
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH-DRDR 1667

Query: 2463 P--ELEVVLTEDALKSLENQTYFKSF-EENGKGSIINLETRLLQLESTVSAKDLELT-QC 2518
               E E +L E   + L  Q   + F EE  +      E + LQ E  +  ++LE   + 
Sbjct: 1668 KFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE 1727

Query: 2519 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN--QT 2576
             +Q++   EQ Q   +   +KI+  +++  E+    L  Q +    +E  +  Q+   Q 
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ 1787

Query: 2577 ISSEPERTNIQNLNQLR----EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIA 2632
            + S+      +   QLR    E +L         R  E + Q+ E    L  E+++   A
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRA 1847

Query: 2633 EKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2664
            E+    +EK   E Q+L +  E+K+R++ +++
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQKRRQERERK 1879



 Score =  140 bits (354), Expect = 2e-32
 Identities = 253/1275 (19%), Positives = 526/1275 (41%), Gaps = 180/1275 (14%)

Query: 15   AKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSK----HDVSAHHDLNIDQS--------QC 62
            A+ ++   R  + +GQ   ++Q++KR+   S+     +  AH     ++         Q 
Sbjct: 714  ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773

Query: 63   NEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCS 122
             E      QR+ +         R L + E    EQ F  E E +          E     
Sbjct: 774  EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE-LQ 832

Query: 123  FV-----MRTGKPTNLLREEEFGVDDSYSEQGAQDS------------------------ 153
            F+     ++  +    L+EEE G+ +    + +Q+                         
Sbjct: 833  FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892

Query: 154  PTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTAN 213
            P   E +  E    Q E EEL RE  E R     E  +Q +E E   ++ + ++ +    
Sbjct: 893  PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE--RQYREEEQLQQEEEQLLRE---- 946

Query: 214  LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA-----DLLQAKQ 268
             ++ +R + E  R++     + +KLQ + +QL   E  +              +L Q ++
Sbjct: 947  -EREKRRRQERERQY----RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001

Query: 269  QILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKE 328
            Q+L  +++   +      Y+KK E    +   L+E+ +   +++ ++     +E  QE+E
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061

Query: 329  TII-EELNTKIIEE-----------------------EKKTLELKDKLTTADKLLGELQE 364
             ++ EE  T+  +E                       EK+  + +++    ++ L + +E
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121

Query: 365  QIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF--ETDIVQRM 422
            Q++++ +E K  + EL    ++E +  +E +QL+    E ++R   + Q+  E ++ Q  
Sbjct: 1122 QLLREERE-KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180

Query: 423  EQETQRKLEQLRAELDEMY--GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS--- 477
            EQ  + + E+ R E +  Y   +++ + K++   +   Q  ++K + + E ENA+R    
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240

Query: 478  YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL 537
            Y     NE   +L        + +L+D  SQ++ L+  LG   E     +R+     +  
Sbjct: 1241 YCKGRENEQFRQLE-------DSQLRDRQSQQD-LQHLLGEQQERDREQERRRWQQRDRH 1292

Query: 538  SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYK 597
                EQ++R  Q  A++  + ++  K L                R+E E K   + T+ K
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQL---------------LREEREEKRRRQETDRK 1337

Query: 598  IKLE--MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEK- 654
             + E  +L++ +   L R    ++   E LR      H+E+  K  E+ +   R   E+ 
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFREEELR------HQEQGRKFLEEEQRLRRQERERK 1391

Query: 655  -LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
             LK+   +  +++   L+ +  +K      E++  +++Q +      K ++ +Q +   +
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFR----EEEQQLSRQER----DRKFREEEQQVRRQE 1443

Query: 714  SEEMTLQINELQKEIEILRQEE----KEKGTLEQEVQELQLKTELLEKQMKEKENDLQ-- 767
             E   L+      E + LRQE     +E+  L QE +E QL  +  +++  E+E  L+  
Sbjct: 1444 RERKFLE------EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497

Query: 768  ---EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824
                KF + E  +   + E+K LE+  ++H    Q + L     ++ + +     ++ + 
Sbjct: 1498 ERDRKFREQELRSQ--EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555

Query: 825  LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884
               E E L+Q+  +  +++ +Q     F  +  +V  QE + ++   ++ +  L   + +
Sbjct: 1556 KFREEEQLRQE--REEQQLSRQERDRKFRLEEQKVRRQEQERKF---MEDEQQLRRQEGQ 1610

Query: 885  QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVE--------- 935
            Q+L  +   K   +E  LQ      +  +    + D+ F+ E  ++              
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQ----ERDRKFLEEEPQLRRQEREQQLRHDRD 1666

Query: 936  ---KDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSL 992
               ++  +L+++ E  +  + E  ++  +  +QL+++  E  FL EE +  +QE E+   
Sbjct: 1667 RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER--- 1723

Query: 993  RCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052
            + RE E +      E ++  +     L +  +       +    + ++ F EE ++  E 
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783

Query: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQ 1112
            +   E     +ES ++    + L    +E  LR  Q   + K + E   L+ E+ + RL+
Sbjct: 1784 E---EQQLRSQESDRKFREEEQLRQEREEQQLRPQQ--RDGKYRWEEEQLQLEEQEQRLR 1838

Query: 1113 MEAQR-ICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQT 1171
             E  R       ++T     RE  E  +++     +E     +EE I+  QK  Q   Q 
Sbjct: 1839 QERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898

Query: 1172 --MKTQETGDEGKPL 1184
              +K+QE    G+ L
Sbjct: 1899 GEIKSQEGKGHGRLL 1913



 Score =  135 bits (341), Expect = 6e-31
 Identities = 242/1224 (19%), Positives = 521/1224 (42%), Gaps = 161/1224 (13%)

Query: 2    EDEERQKKL---EAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNID 58
            E+E RQ+ L   E  + +  Q R+ + +   Q   ++++++R     K +   H +   +
Sbjct: 626  EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE---HEEERRE 682

Query: 59   QSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEV 118
            Q    E    + +R++S  IP+                  +  +LESE    AD   S+V
Sbjct: 683  QELAEEEQEQARERIKSR-IPK------------------WQWQLESE----ADARQSKV 719

Query: 119  NGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNREL 178
                   R  K     R +E        E+  +   + L+  E E A +Q + EE  R+ 
Sbjct: 720  -----YSRPRKQEGQRRRQE-------QEEKRRRRESELQWQEEERAHRQQQEEEQRRDF 767

Query: 179  --EEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREK---DETMREFLELTE 233
              +         G Q+L       +QR+    QL A  +Q R ++   +E  +E      
Sbjct: 768  TWQWQAEEKSERGRQRLSARPPLREQRE---RQLRAEERQQREQRFLPEEEEKEQRRRQR 824

Query: 234  QSQKLQIQF----QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQD--HLLEDY 287
            + ++ ++QF    +QLQ  E  +         D LQ  Q+    Q+Q  +Q     LE+ 
Sbjct: 825  REREKELQFLEEEEQLQRRERAQQLQEEE---DGLQEDQERRRSQEQRRDQKWRWQLEEE 881

Query: 288  QKKKEDFTMQISFLQEKIK------------VYEMEQDKKVENSNKEEIQEKETIIEELN 335
            +K++         LQE+++            +   E++K+     + + +E+E + +E  
Sbjct: 882  RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941

Query: 336  TKIIEE-EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEI 394
              + EE EK+  + +++    DK L + +EQ++ +  E K  + E     ++E +  +E 
Sbjct: 942  QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE-KRRRQEREKKYREEEELQQEE 1000

Query: 395  KQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIR 454
            +QL+    E ++R   + Q+      + E+E   + E+ +  L E   Q     ++E ++
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ---YREEEELQ 1057

Query: 455  QHMAQM--EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKL 512
            Q   Q+  EE +TR + E+E   R    +   E+Q+             L++   ++ + 
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL-------------LREEPEKRRRQ 1104

Query: 513  KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLK 572
            + E     EE+  LQ++ E L+ E    R + +  RQ   E+E +  E        + L+
Sbjct: 1105 ERERQCREEEE--LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE-------QLLR 1155

Query: 573  AEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS 632
             E         E + + E E+   + +L   E+EK          +E EL+R + +  + 
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215

Query: 633  HEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQ 692
             E++ S LK   E E        K+N     K    G +NE  +++E  Q  +D    + 
Sbjct: 1216 DEDQRSDLKWQWEPE--------KENAVRDNKVYCKGRENEQFRQLEDSQL-RDRQSQQD 1266

Query: 693  NQLILEISKLKDLQQ----------------SLVNSKSEEMTLQINELQKEIEILRQEEK 736
             Q +L   + +D +Q                 L   + +E   +  + Q+E ++LR+E +
Sbjct: 1267 LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326

Query: 737  EKGTLEQEVQELQLKTELLEKQMKE--KENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
            EK   ++  ++ + + +LL+++ ++  +  +   KF + E  +   +  +K LE+  ++ 
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ--EQGRKFLEEEQRLR 1384

Query: 795  TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
                QE    FL   K + +    E+E ++  + +   +++     +++ +Q     F E
Sbjct: 1385 ---RQERERKFL---KEEQQLRCQEREQQLRQDRDRKFREE----EQQLSRQERDRKFRE 1434

Query: 855  KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE-ELHLQRINPTTVKMK 913
            +  +V  QE + ++   L+ +  L   ++++  E +  L+   E +LH Q  +   ++ +
Sbjct: 1435 EEQQVRRQERERKF---LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491

Query: 914  SSV--FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQ----RLSDLSEQLK 967
              +   + D+ F  + L   E  E+   E  ++L   +R++  L +    R  +  +Q +
Sbjct: 1492 QQLRRQERDRKFREQELRSQE-PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550

Query: 968  QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027
            Q   +  F  EE    ++E++Q+S + R+ +  +     + V+  + +   + D      
Sbjct: 1551 QDR-DRKFREEEQLRQEREEQQLSRQERDRKFRLEE---QKVRRQEQERKFMEDEQQLRR 1606

Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT 1087
              G +    + ++ F E+ +++ E +   E     +E  +++  L+  P + ++   +  
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQERE---EQQLHRQE--RDRKFLEEEPQLRRQEREQQL 1661

Query: 1088 QPSENDKLQKELNVL-KSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
            +   + K ++E  +L + E+  LR Q   ++           ++ R++++ E+      L
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721

Query: 1147 KEELIFAQEEKIKELQKIHQLELQ 1170
            + +  F +EE++++  +  QL  Q
Sbjct: 1722 ERK--FREEEQLRQETEQEQLRRQ 1743



 Score =  108 bits (271), Expect = 8e-23
 Identities = 251/1261 (19%), Positives = 503/1261 (39%), Gaps = 161/1261 (12%)

Query: 2286 IIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVK 2342
            ++Q++  E DQ   +     +QL+     +  +++ E  R+L   E Q E     ++  +
Sbjct: 109  LLQDRRQEEDQ--RRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDR 166

Query: 2343 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE--EADSLKHQLDVVIAEKLALE- 2399
            + R+EE+ +  +  ++ ++  A   Q  S   H   E  + + L+ +  + +  K   E 
Sbjct: 167  QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEK 226

Query: 2400 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK-IQSIPENSVNVAIDHL 2458
            QQ     ++  F +   KE   +   L +E   L+ E    ++ +Q   E    +    L
Sbjct: 227  QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286

Query: 2459 SKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQC 2518
             +++ E E    +   +    Q   +  EE  +        +  + E     ++ +L + 
Sbjct: 287  RRERQEEE----QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342

Query: 2519 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ--DNQT 2576
             ++ ++ Q + + E E  ++++   Q+  EE+    L  + QL   Q+  +  Q    Q 
Sbjct: 343  QEERREQQLRREQEEERREQQLRREQE--EERREQQLRREQQLRREQQLRREQQLRREQQ 400

Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
            +  E +    Q L   RE +L  +     LR  + E +  + H     E+E+ E   K  
Sbjct: 401  LRREQQLRREQQLR--REQQLRREQQ---LRREQEEERHEQKH-----EQERREQRLKRE 450

Query: 2637 LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRA 2696
             E+ +  L+ ++  E +E+++R+++ KR  Q+ E  +   +L             + LR 
Sbjct: 451  QEERRDWLKREEETERHEQERRKQQLKRD-QEEERRERWLKLEEEERREQQERREQQLRR 509

Query: 2697 ESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2756
            E    + +    +E+ E+LQ+ L  ++           Q+R    E +E+L  L++E+E 
Sbjct: 510  EQEERREQRLKRQEEEERLQQRLRSEQ-----------QLRREQEERREQL--LKREEEK 556

Query: 2757 EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEE 2816
             +++ ++         +L +    + D  LK     +  ++  +    +  L+     EE
Sbjct: 557  RLEQERREQ-------RLKREQEERRDQLLKREEERRQQRLKREQ---EERLEQRLKREE 606

Query: 2817 VTEIISQFTE----KIEKMQELHAAEILDMESRHISETETLKREHYVA-VQLLKEECGTL 2871
            V  +  +       K E+ +E    ++L  E +     + L+RE      Q LK E    
Sbjct: 607  VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666

Query: 2872 KAVIQCLRS-KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGE 2930
            +   +  R  +E     ELA  +  Q RE   S     W   +            E   +
Sbjct: 667  RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK-WQWQL------------ESEAD 713

Query: 2931 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2990
              +S   S P+K +G  R    E  +    +E  + + E    QQ  E   E+R+     
Sbjct: 714  ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE---EQRR----- 765

Query: 2991 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3050
                 D   + Q + ++E              RG   L+ +    E+R   L A   +  
Sbjct: 766  -----DFTWQWQAEEKSE--------------RGRQRLSARPPLREQRERQLRAEERQQR 806

Query: 3051 ALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA----QMNGRKI 3106
                          EQR   +  E +      ++  RR    E+Q L      Q   R  
Sbjct: 807  --------------EQRFLPEEEEKEQ-----RRRQRREREKELQFLEEEEQLQRRERAQ 847

Query: 3107 TLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRAT-----ELQEQLSSEKMVV 3161
             L+ E++  +  QE      +Q++ Q    Q+E    + R T      LQEQL  E+ ++
Sbjct: 848  QLQEEEDGLQEDQERRRSQ-EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906

Query: 3162 AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQ 3221
             E + EL + + E       + +  ++   +R E + + +E  LL +     +++ RE Q
Sbjct: 907  QEEEEELQREERE-------KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959

Query: 3222 WALEK-----EKAKLGRSEE-----------RDKEELEDLKFSL---ESQKQRNLQLNLL 3262
            +  +K     E+  LG   E           R++EEL+  +  L   E +K+R  +    
Sbjct: 960  YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019

Query: 3263 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3322
              ++ +L  E +Q +  +R     Q  E Q R  E + L + E+  + E   T  R +EL
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYR--EEEELQQEEEQLLGEERET-RRRQEL 1076

Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEK 3382
              Q +  +   Q    L  E+  K  +++ E +     EL  E E+   +  + R++ E 
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 3383 DRQVHRK---TLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGI 3439
            +RQ   +     + EQ    E +K+  +   +    + +L+++ +Q+ + + E +R +  
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196

Query: 3440 MQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLI 3499
             Q  +++EL+R+++++  R   Q  +    W        N V   K+  + +E+   + +
Sbjct: 1197 RQYREEEELQRQKRKQRYRDEDQRSDLKWQW---EPEKENAVRDNKVYCKGRENEQFRQL 1253

Query: 3500 E 3500
            E
Sbjct: 1254 E 1254



 Score = 99.8 bits (247), Expect = 5e-20
 Identities = 230/1155 (19%), Positives = 448/1155 (38%), Gaps = 199/1155 (17%)

Query: 2625 EKEQVEIAEKNVLEK--EKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSN 2682
            E+EQ++  + +  E+  +++ L  ++LLE   K + EK+++R  +   V +   E     
Sbjct: 189  EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248

Query: 2683 EESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAE 2742
             E+    E E L+ E    + EL   +E+  KL+ + L +E      Q+   + R+    
Sbjct: 249  RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR-REQQLR 307

Query: 2743 AKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNA 2802
             K++    E+++E   Q+ ++    E    +L +    + +  L+     +  +      
Sbjct: 308  RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ----- 362

Query: 2803 GIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ 2862
              Q+  + E   EE  E   +  +++ + Q+L   + L  E + +   + L+RE     Q
Sbjct: 363  --QLRREQE---EERREQQLRREQQLRREQQLRREQQLRREQQ-LRREQQLRREQ----Q 412

Query: 2863 LLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFD 2922
            L +E+   L+   Q  R +E     +    +  + R     +   DW +           
Sbjct: 413  LRREQ--QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK----------- 459

Query: 2923 IASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV-LSLTESPYSDGEDHSIQQVSEPWL 2981
                    E E+      ++ + L R    E  +  L L E    + ++   QQ+     
Sbjct: 460  -------REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512

Query: 2982 EERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVL 3041
            E R+                +L+R+ E     Q   S    R E     +Q+   E    
Sbjct: 513  ERRE---------------QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE--- 554

Query: 3042 LAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM 3101
                                   E+R++++  E +   E  ++ D        Q L  + 
Sbjct: 555  -----------------------EKRLEQERREQRLKREQEERRD--------QLLKREE 583

Query: 3102 NGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV 3161
              R+  LKREQE      E LE  +++++ + LE +        R  E  E+   ++++ 
Sbjct: 584  ERRQQRLKREQE------ERLEQRLKREEVERLEQEERREQRLKR--EEPEEERRQQLLK 635

Query: 3162 AELKSELAQTKLELETTLKAQHKHLKELEAFRLE--VKDKTDEVHLLNDTLASEQKKSRE 3219
            +E + E  Q +L  E   + + +  +E E  RLE  +K + +E     +    EQ+++RE
Sbjct: 636  SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695

Query: 3220 L--------QWALEKEK-AKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
                     QW LE E  A+  +   R +++        E Q++R  Q      ++K+  
Sbjct: 696  RIKSRIPKWQWQLESEADARQSKVYSRPRKQ--------EGQRRRQEQ------EEKRRR 741

Query: 3271 NESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERE-LHAQLQSS 3329
             ES+ + + +   +  Q  EEQ R+   Q   E +  R R+  S     RE    QL++ 
Sbjct: 742  RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE 801

Query: 3330 DGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL-----------DSLQT-- 3376
            +   + +  LP E+  ++ ++Q  E+   + + L E E+ +            D LQ   
Sbjct: 802  ERQQREQRFLPEEEEKEQRRRQRREREKEL-QFLEEEEQLQRRERAQQLQEEEDGLQEDQ 860

Query: 3377 --------------RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK 3422
                          R Q+E++R+  R TL  +     + +K+   LQ + E+LQR+  EK
Sbjct: 861  ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK 920

Query: 3423 --RQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL----------YQNLNEPTTW 3470
              RQ+  +   E ++LQ   ++  ++E E+  ++E  R             Q L E    
Sbjct: 921  RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980

Query: 3471 SLTSDRTRNWVLQQKIEGETK---------------ESNYAKLIEMNGGGTGCNHELEMI 3515
                +R + +  +++++ E +               E  Y K  E+         E +++
Sbjct: 981  RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ------QEEEQLL 1034

Query: 3516 RQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQE----NIDEIILQLQKLTGQQGEE 3571
            R++ +    K ++  ++   R + E   +E+ +  +E       E+  Q +K    Q EE
Sbjct: 1035 REERE----KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090

Query: 3572 PSLV--SPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAG 3629
              L+   P        ER  R+  EL     QL  E+ + R    +LE Q R   +    
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR-QELERQYREEEEVQQE 1149

Query: 3630 RDNSSRF--SLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAE---VYKLKAELRNDS 3684
             +   R          +E     E+E+   E+  L++  ++   E    Y+ + EL+   
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQK 1209

Query: 3685 LLQTLSPDSEHVTLK 3699
              Q    + +   LK
Sbjct: 1210 RKQRYRDEDQRSDLK 1224



 Score = 93.2 bits (230), Expect = 5e-18
 Identities = 135/573 (23%), Positives = 240/573 (41%), Gaps = 59/573 (10%)

Query: 3083 QKADRRSLLSEIQALHAQMNGRKITLKREQESE-------KPSQELLEYNIQQKQSQMLE 3135
            Q+ D+R      + L  +   R+   ++EQE E          QE LE   +Q++ + L 
Sbjct: 115  QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW 174

Query: 3136 MQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTK----LELETTLKAQHKHLKELEA 3191
             Q +    ++     +EQL S K    E   +  Q +    LEL    + + +  +    
Sbjct: 175  RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234

Query: 3192 FRLEVKDKTDEVHLLNDTLASEQKK--------SRELQWALEKEKAKLGRSE---ERDKE 3240
             R+  +++  E       L  E++K         RELQ   E++  KL R E   ER +E
Sbjct: 235  DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ-EEEEQLRKLERQELRRERQEE 293

Query: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300
            E +  +   E Q +R  +     +Q+++   E Q++ E Q    + QL  EQ    E Q+
Sbjct: 294  EQQQQRLRREQQLRRKQEEERREQQEER--REQQERREQQEERREQQLRREQEERREQQL 351

Query: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3360
              E E+ R  +       E     QL+      + +     + L +E Q + E++  R  
Sbjct: 352  RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411

Query: 3361 ELLNETEKYKLDSLQTRQQMEKDRQVH-----RKTLQTEQE-----ANTEGQKKMHELQS 3410
            +L  E +  +   L+  Q+ E+  Q H      + L+ EQE        E + + HE + 
Sbjct: 412  QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471

Query: 3411 KVEDLQR-QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE-EKRESRRILYQNLNEPT 3468
            + + L+R Q EE+R++  KL+ E +R Q   QE ++Q+L RE E+R  +R+  Q   E  
Sbjct: 472  RKQQLKRDQEEERRERWLKLEEEERREQ---QERREQQLRREQEERREQRLKRQEEEERL 528

Query: 3469 TWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKL--QCVASKL 3526
               L S++      +++ E   K     K +E          E E  R +L  +    + 
Sbjct: 529  QQRLRSEQQLRREQEERREQLLKREE-EKRLEQERREQRLKREQEERRDQLLKREEERRQ 587

Query: 3527 QVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTE 3586
            Q L ++  ERL+     +E      E +++   + Q+L  ++ EE              +
Sbjct: 588  QRLKREQEERLEQRLKREE-----VERLEQEERREQRLKREEPEE-----------ERRQ 631

Query: 3587 RLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3619
            +LL+   +      QL  E+ + R   +K EE+
Sbjct: 632  QLLKSEEQEERRQQQLRREQQERREQRLKREEE 664



 Score = 89.0 bits (219), Expect = 9e-17
 Identities = 136/659 (20%), Positives = 263/659 (39%), Gaps = 97/659 (14%)

Query: 7    QKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMY 66
            +++LE  + K A+ R RK+Q + Q   +++++KR+   +         L           
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL----------- 1344

Query: 67   INSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMR 126
                Q  E   +      R     E+   EQG    LE E                 + R
Sbjct: 1345 ---LQEREEQPLRRQERDRKFREEELRHQEQGRKF-LEEE---------------QRLRR 1385

Query: 127  TGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYG 186
              +    L+EE+        +Q  QD        E +L+ ++ + +    E +  R    
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445

Query: 187  TEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE----LTEQSQKLQIQF 242
             + L++ Q+      ++     QL    ++ +  + E  R+FLE    L  Q +  + + 
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505

Query: 243  QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
            Q+L++ E  R            Q +++ L  +QQL  Q+   +  Q +   F  +    Q
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565

Query: 303  EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362
            E+    E +Q  + E   K  ++E++   +E   K +E+E++    + +     +L  E 
Sbjct: 1566 ER----EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ----QQLRQER 1617

Query: 363  QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF--ETDIVQ 420
              +  +  Q ++  + +  + ++++R+  EE  QL     E Q R+ +D +F  E  ++Q
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677

Query: 421  RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
              E++  R     R E D  + ++  Q++++   +   Q E+   R   E+E   R    
Sbjct: 1678 EGEEQQLR-----RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ--ELERKFR---- 1726

Query: 481  ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
                E+Q++             Q+T  ++ + +E    ILEE+     QL    EE    
Sbjct: 1727 ---EEEQLR-------------QETEQEQLRRQERYRKILEEE-----QLRPEREEQQLR 1765

Query: 541  REQIQR-------ARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV 593
            R++  R        RQ   EQ+ +  E+ +     E L+ E       R+E +L+ +   
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQE-------REEQQLRPQQRD 1818

Query: 594  TNYK-----IKLEMLEKEKNAVLDRM--AESQEAELERLRTQLLFSHEEELSKLKEDLE 645
              Y+     ++LE  E+      DR   AE Q A  E+ R +     +EE  K +++ E
Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE 1877



 Score = 79.3 bits (194), Expect = 7e-14
 Identities = 109/488 (22%), Positives = 217/488 (44%), Gaps = 81/488 (16%)

Query: 3065 EQRIQEQGVEYQAAMECLQKADRRSLL------SEIQALHAQMNGRKITLKREQESEKPS 3118
            E+ +Q++  E Q   E  +K  R+ L        E+Q    Q+   +   +R QE E+  
Sbjct: 1113 EEELQQE--EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170

Query: 3119 QELLEYNIQQKQSQML-EMQVELSSMKDRA----TELQEQLSSEKMVVAELKSELA-QTK 3172
            +E  E  +QQ++ Q+L E Q +    ++R      ELQ Q   ++    + +S+L  Q +
Sbjct: 1171 RE--EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWE 1228

Query: 3173 LELETTLKAQHKHLK--ELEAFRL----EVKDKTDEVHLLNDTLASEQKKSRELQ---WA 3223
             E E  ++    + K  E E FR     +++D+  +  L +  L  +Q++ RE +   W 
Sbjct: 1229 PEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH-LLGEQQERDREQERRRWQ 1287

Query: 3224 -----------LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNE 3272
                       LE+E+ K  +  +R  +E + L      +K+R  + +    +++QLL E
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347

Query: 3273 SQQ----KIESQRMLYDAQLS-EEQGRNL------------ELQVLLESEKVRIREMSST 3315
             ++    + E  R   + +L  +EQGR              E + L E +++R +E    
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407

Query: 3316 LDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3375
            L ++R+   + +    + Q R     E+  +  +++ E K     + L +    K    +
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467

Query: 3376 TRQQMEKDRQVH-----RKTLQTEQE-ANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKL 3429
               Q  +++Q+H     RK L+ EQ+    E  +K  E + + ++ +R+  E+ QQ+++ 
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR- 1526

Query: 3430 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE 3489
                QR +  +QE  +Q+L R+E+ + RR                DR R +  ++++  E
Sbjct: 1527 ---QQRQRKFLQE--EQQLRRQERGQQRR---------------QDRDRKFREEEQLRQE 1566

Query: 3490 TKESNYAK 3497
             +E   ++
Sbjct: 1567 REEQQLSR 1574



 Score = 36.2 bits (82), Expect = 0.66
 Identities = 68/312 (21%), Positives = 121/312 (38%), Gaps = 43/312 (13%)

Query: 3391 LQTEQEANTEGQ------KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQ 3444
            L  E+ A  +G+      ++  E Q + E   RQLEE+          GQR +   QE +
Sbjct: 95   LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEE---------PGQRRRQKRQEQE 145

Query: 3445 KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGG 3504
            ++  E EE+ E +  L Q   +     L   R + W  +++   E ++    K       
Sbjct: 146  RELAEGEEQSEKQERLEQRDRQRRDEELWRQR-QEWQEREERRAEEEQLQSCK------- 197

Query: 3505 GTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENID-----EIIL 3559
                 HE E    + Q    +L  L +K  E  Q +  + +D ++ +E        E +L
Sbjct: 198  ----GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253

Query: 3560 QLQKLTGQQGEEP----SLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMK 3615
            + ++   Q+ EEP     L         L  + LR+  +      Q    +  LR    K
Sbjct: 254  RKEEEKLQE-EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR---K 309

Query: 3616 LEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK 3675
             EE+ R   Q    R+   R         E  +  E+E    ++L  ++  +R E ++ +
Sbjct: 310  QEEERR--EQQEERREQQERREQQEERR-EQQLRREQEERREQQLRREQEEERREQQLRR 366

Query: 3676 LKAELRNDSLLQ 3687
             + E R +  L+
Sbjct: 367  EQEEERREQQLR 378


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  191 bits (486), Expect = 9e-48
 Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)

Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
            +++  EE   D +Q+   +  + Q+ +Q++E   QA  RQ E     + +++EEI+ +  
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459

Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
            QL     QR   + E    +  R   EE EA K+ +    E+L  ++++ S   Q   + 
Sbjct: 1460 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1513

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
            + E+  +   E E  R+ +    + L   R   ++A  RL +  +E  +      ET   
Sbjct: 1514 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1570

Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
                   RS++++  +     +E  A ++  + EEH  V                     
Sbjct: 1571 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1603

Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
            +++ EE    +Q+   +  A  E + E E  +L  N + RL+   E++ +  S   ++ E
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
              K    E  RE+ R+ +   ++++ +E   + L ++ +  E  A +   AE  +     
Sbjct: 1664 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720

Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
            E    E+Q Q   + + RL++E   A+ + QELEAE  +++ E E+L             
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
               + K+ ++AEAG   ++L +E  +L     E + Q +   +D  +Q    E  + E++
Sbjct: 1781 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839

Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
            +   E  + K    + L+++    E + E++R+  +++A  R    +   Q    +E++L
Sbjct: 1840 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
                        Q R+     + L+ +     + L  + Q++ +I       EK      
Sbjct: 1896 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942

Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
            ELE  L      + DT +  E        +A+ E + + QL AE     R+A +R +K +
Sbjct: 1943 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1994

Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
               EE   Q +  L    EEV++L  ++E  ++      QE  ++ +L ++  +K   A 
Sbjct: 1995 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050

Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
            +++ A + Q +     +  Q +Q+++  +DQL  +              ++Q + +    
Sbjct: 2051 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107

Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
             + +EE   L +  E Q +     Q   ++ R+E  +   E   + Q E A + QK + +
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2164

Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
            A     E +  K   +  + +K  +EQ       E+T ++  L+ET+ + N L +EL  L
Sbjct: 2165 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2212

Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
            K E     + +S  E    SV V ++ LSK K  +E       L+  +N   F   EE  
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2271

Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
            K   +  E   L + +  +A+  +L +     +D+ +Q     +ML++K+  +Q+    K
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2326

Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
              A L+ Q Q E  QE A+  Q+++   ++      Q   +       R+ E+ ++   L
Sbjct: 2327 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385

Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
             LR++E+                  E    ++H + +  +E+V + +   +++++   + 
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445

Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
            ++L E   + +REKEK +  Q+ ++L+  +E   + ++     E +AL+   ++ K  L 
Sbjct: 2446 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503

Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
                     K K E+L ++ + K   +       Q+ + Q R  L  + E+    + E E
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563

Query: 2756 TEVQESKK 2763
              V+  ++
Sbjct: 2564 EGVRRKQE 2571



 Score =  167 bits (424), Expect = 1e-40
 Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)

Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
            PE       + S L+  + KL +  S ++  LE  K     +     R  Q A E L+  
Sbjct: 1054 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1108

Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
            EE         + +E  AV  +  E      + +K   + + Q+ T   D L  EL  A 
Sbjct: 1109 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1156

Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
               QE+    QQ   ER++   +     A+     Q +L +T+   +E  ++  Q    R
Sbjct: 1157 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1213

Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
            +        L+ D   +  +   +    +  + +  +Q QAL +++E+  + ++E Q   
Sbjct: 1214 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272

Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
            +++   +   E+Q +  + QL+ V      P+ Q  SE   +E   L  H  E T   S+
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1332

Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
                       I+  +E + ++E   R  EQ         Q+ E+R+    VEA      
Sbjct: 1333 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1373

Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
               E   + + QAER+A +   R ++E+   EE     +++  +  EE+QQL    E + 
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
            +    + +  E+     ++++  + L ++ ++      +  L    A+  +E E +  Q 
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1492

Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
             E+  +L++Q         ++++++  R  E ++   +  +    R ++  ++ L E+  
Sbjct: 1493 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1541

Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
            +LQ                 +EEA+    Q +V  A ++  ALE    +A  E+   +  
Sbjct: 1542 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584

Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
              E   ++ +      SL+ E  +V +++   E       +   + + E E  L    LK
Sbjct: 1585 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1637

Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
            + E                  L  RL Q E     K L   +  KQ ++ + +    G+ 
Sbjct: 1638 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679

Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
            E + ++++ +  Q++ +++  A   +Q +L A QE  +       + +E E+   Q   Q
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1730

Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
            L E+EL     + +A T +  ELE+++ ++      L+  K + E   ++  EK K+ LE
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790

Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
                 E    ++  +E  R     E  K   +L    EE       EA R  AE +A   
Sbjct: 1791 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1843

Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
            E    K +AE   +E   +   +  L +D +        Q   H A+ +E+L+ L K  +
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
            +E++  K          +    E L +K S   A+     L++               I+
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1952

Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
             N +    S+E  E+ +    ++   +E    E  +   + ++  E   R+   A+    
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 2008

Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
            EE   LKA ++  R       +E +   +LA   A    Q  E   + +     Q +  T
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
              Q   +  + RGE +E+A  +          A   E  +V +  E+  S  +    +++
Sbjct: 2069 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2117

Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
             +   E+ +A     ++ + L  + + +  R A+   ++   +  +D   E      +  
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177

Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
            L +++ +     T    L  TD     N L++ +Q    E   A     + +      R 
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235

Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
             + E+  L A++    R + L+ +  +++  QE  E     K  Q+ E    LS     A
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2290

Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
              L         Q++  +EKM+  ++++    T+L+ E  L  Q K L + +A RL+   
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2350

Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
            +     L  +T       E ++ R+L+ + E E+ KL      R++ R +E+ +  +   
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410

Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
            E   ++ L    L  Q+K  L ++ + I+ Q+  +DA+   E    LE +     ++ ++
Sbjct: 2411 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468

Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
             ++ S   +  +    LQ +    QS   L  +D L + ++ +E++ +++ +L  +    
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2526

Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
             ++ + +  + +QQME++RQ   + + + +EA     +    ++ K E+LQ+  +++RQQ
Sbjct: 2527 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583

Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
               L  E QRL+  +Q  ++Q
Sbjct: 2584 EELLAEENQRLREQLQLLEEQ 2604



 Score =  158 bits (399), Expect = 1e-37
 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)

Query: 153  SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
            +PT    +E  L GK  ++  L+   LE+++    V  GT+G ++ L+  E  +K+   +
Sbjct: 1060 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118

Query: 207  ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
               L       A+L++ R + +     F  L ++   +Q++  + QQ      +      
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178

Query: 258  STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
               A LL+  Q +L      Q++LE+    L  Y++  +      ++LQ+  +  E  Q 
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1235

Query: 314  KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
              + +S   +E++++++ ++EE+        +K  E +         + + + Q+V    
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1291

Query: 372  EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
            +++ +       K +    S  +E   L     EL     +  +F ++ ++RME+E +R 
Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1350

Query: 430  LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
             EQ RAE                 L E + Q   Q ++E         EE+  R +  ++
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410

Query: 473  NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
               +  S   + E+  +L   +  E+  K +   + +    +++EE+ ++   LE     
Sbjct: 1411 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467

Query: 522  ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
                  E  AL+ + E+   +   ++E+ +R R+ + ++  +  +A   L++   +KAE 
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1525

Query: 576  VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
             +A E ++ L    EL+ +AE    +++   +E+ +     L+    S EAEL+  R   
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1583

Query: 630  LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
              S  E+ ++L+  L+ EH + + +L++      +QQ +    + E  +++E  Q + + 
Sbjct: 1584 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640

Query: 688  LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
             +  + Q   E+++ K L Q+              E +K+ E   +E + +G   EQ V+
Sbjct: 1641 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1685

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            + +L  + LEKQ +  E   Q++ A   AE  +++         L+  T   +++R +  
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1733

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
            + +      +  ++E     ++ ++L+ +  ++  E+           E+ R+T   +++
Sbjct: 1734 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787

Query: 856  NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
              E     ++EL EE A L  + ++        E+   +Q  E +     KL A+ E   
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847

Query: 902  LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
            L+      +K K +  +      ED+ F    LE  E   +   ++ E+L ++ K    E
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1905

Query: 955  LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
            L ++   + + L+Q+      + EE+ +LK   E+ +    ELE+ +   R+    +  +
Sbjct: 1906 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961

Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
            +  + L+      +     R    +  +V KS   E +   + K + E +   +   +E 
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021

Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
              L           L+  Q +   +LQ E   +    +Q +  LQ   Q+        + 
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2075

Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
            +DQ+R   E  + +A    +E  + A+ E  +  +++ + E      +E           
Sbjct: 2076 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134

Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
              KL+K   +E +   Q   + L +      + E + +  E              Q  R 
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2180

Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
            + Q  QE + TL  ++ E  ++  +L   L ++  + T+  +         + E E  S+
Sbjct: 2181 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2233

Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
              QM  L  +   +  +++   L+D + T+  L+E+ ++++ +      +S   Q+    
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293

Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
             Q  E ++          L++++QAV E+T       L      + +  A+R       +
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353

Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
             + +            +E     + LE + Q QLE       + + +A     E+SR   
Sbjct: 2354 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2397

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
              E  A   +  A    E+ +  E+   +     QT E    +   + + L + + E  +
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457

Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
            E      +   +    + + T+ +E   ++ T  ++QS   E   S +   R +   + +
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2515

Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
            LE +        Q+L  + Q  QQ  E  RQ  +  ME  R  Q + +E ++R   +L Q
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575

Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
              +     E L++E  + L E+L+ L++    +LA  E++      ++    NG +
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631



 Score =  149 bits (376), Expect = 5e-35
 Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)

Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
            A E++  +R I E  DI  +LE    C +  +  L     + +  RE   R  E  KA+A
Sbjct: 976  AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1031

Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
                 G    +L  E EK++    E    A  +R +L+  +  LE     QV     +  
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1085

Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
            EK   +  + +  Q  E+ L    + L E QA+     E +  +  ++KL  Q +   P 
Sbjct: 1086 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1145

Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
            F  + + + R  +++   L+++  ++  E+   +E++ + ++     + + + R RELEQ
Sbjct: 1146 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
             L      +++  D       +A+     + Q+QA   A  +  +E    E+ L    EE
Sbjct: 1205 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1257

Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
            +E   E+V++         K+    +++ E +   +K  +E +    K+    S  +   
Sbjct: 1258 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1311

Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
                   +IQE        +E  T   Q +K  +         E +R +E + E L   Q
Sbjct: 1312 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1354

Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
               +R R  E+E     +EK Q++LA    +    A   ++E    + Q +VV  E+ A+
Sbjct: 1355 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1409

Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
            + Q +         K  ++E   ++ Q ++ E+ +  R+ E+ E+               
Sbjct: 1410 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1445

Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
             S+ + E E+ +    L++ E Q          +G +  L  R  + E+       E  +
Sbjct: 1446 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1498

Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
              +Q++D  Q + Q E E+  +     +   E++ A   + +++L+A +E  +  +  + 
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1557

Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
              +   +  ++   +  E EL S  ++   + ++LE  + E H ++   +E+ E   +  
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617

Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
             E E+   E ++ LE  + K  E            +++S    E  K   E        G
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677

Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
               E +A+R   +A + EL   ++ AE   ++ L  E  +  L+ +  Q        +E+
Sbjct: 1678 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735

Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
            L+ L++E     Q     E++ A +   + + L+    ++ +     S+S ++ Q L   
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1792

Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
            AG    L  E +      E  +   Q  E+    Q   A  +L  +   I E   LK E 
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852

Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
             +A   LKE            +  E   +  LA  +A+Q R +                 
Sbjct: 1853 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897

Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
               +SDS  +  +G+               L     F+ A+ G+ E          +A D
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
            +   K +  L A      Q+ +  E    + E+   + ++  E    +RKA +  +  LK
Sbjct: 1958 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015

Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
              + + +  RE    +S++  +   +   + L A               LQQ   +E+SV
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075

Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
            L                   A  + E  A  +   V     L+Q  +EQ     + QAA 
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135

Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
            E L+K   +      QA  A +  ++      ++ +K +++ L    Q +Q ++  ++++
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2194

Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
            L     +   L E+L   K    E   + +Q + EL  +++ Q + L +L+A R+E +++
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2252

Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
               +   ++T    Q+++ +++   E+         E A+L +  E D  +   L   + 
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312

Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
             +K + +Q          LL+QQK+L  E  ++++  +     QL+EE QG         
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372

Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
             R LE+    E  K+R+ EMS    R E +     + ++  G+   R  L +++ +    
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432

Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
              E+Q+Q      E     I EL  E EK          K + +QT QQ +  ++ Q  +
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492

Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
            ++  +E+++  + ++ + + ++K+E L        Q+  EE+++Q  +++ E QRL   M
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552

Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
            +E ++++ E EE    ++   Q L +
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQ 2578



 Score =  146 bits (369), Expect = 3e-34
 Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)

Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
            L+       Q++   +  ++ +RE  RQ+Q   E ++        CQ   ++ ++     
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282

Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
              QL    ++                +E VI  Y D +T       L  + I+  ++ + 
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342

Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
            R+E+E   A         RL E+EA  ++ ++  E  ++ K   + EA  ++Q++ +E  
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402

Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
            +  +  ++ Q Q   ++++LQ+  ++ E +++ +  +    E+ +     E+  +R Q +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462

Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
            A E+Q    E   + L  +A + E ++   Q+E ++L +Q+      Q  S+ + +   +
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1516

Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
            LA+ +K + +   E    K++  + ++E   + E+ E R+R+ E    + + V+ +T Q+
Sbjct: 1517 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
              +      R  F    A+ E SL+       QL+ E +   +++ E     E+ E+  E
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
              + K  E  +L +Q E   ++ +    E E++ +  + +  + G A             
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1679

Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
                      +E+ V   +L EQ  + Q+QL   T  + +  + ELIR        L ++
Sbjct: 1680 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1721

Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
             E      E++ + L E + +LQ+E A   QK       L  E   ++ +++V++A K  
Sbjct: 1722 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1773

Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
             E++  + +E+    K  L+    +  +L +E   L+   E  ++ + + E         
Sbjct: 1774 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830

Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
                      AI   ++ K E E+ L E     + L+ L     F  +  EE       +
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890

Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
            +E RL QL     A D EL +    ++D   Q +     ++++I+ L+   E+  A    
Sbjct: 1891 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1943

Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
             +++L  ++  A+      T+ S+ +      L   R+ +L ++      R  E E +V 
Sbjct: 1944 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1991

Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
            +   SL  E+E      K  LE+ ++L    K      ++ RE+ ++ S + +++ +   
Sbjct: 1992 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2043

Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
            +              + L+AE    KA   + ++K ++LQ+ L  +++ +  L+ +    
Sbjct: 2044 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086

Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
            R    EA+E     E+E      +V+E+++         +      +  +   K +    
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
              +   + A ++    ++   E+  +   Q   +K +  QEL    +       + ET+ 
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2200

Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
             K        LL EE   LKA      +++ S + E   S   Q  E+    +       
Sbjct: 2201 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2246

Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
                      I +E R      +  T  F ++    ++ V  E  ++    +      E 
Sbjct: 2247 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2290

Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
              ++Q++E  L +++A        K L  KMQ  +EA    +              LL  
Sbjct: 2291 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2334

Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
            Q+   +E++  L   + ++      +  G    LE   Q Q +E  A  E L+   R + 
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2391

Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
            +S  QA  A+ + ++   + E+  EK  +   E   Q+K + +  ++++       A  L
Sbjct: 2392 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2448

Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
            +E        +AEL+ E  + KL+ E  L      LK  E   ++ +    E   L  + 
Sbjct: 2449 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2495

Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
             SE+    + +  +E+EKAKL +  + +  + + L+   + Q+Q+       +EQ++Q L
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2548

Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
              S +  E++R  ++A+      +E+ + LE Q      LL  E  R+RE    L+ +  
Sbjct: 2549 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606

Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
                H++  ++     ++      D L     + E +HS
Sbjct: 2607 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645



 Score =  142 bits (359), Expect = 5e-33
 Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)

Query: 417  DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
            DI  ++E    R + +LR  LD+   ++  Q    +  Q  AQ          E+E   +
Sbjct: 991  DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1038

Query: 477  SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
              + ++   +++  +   + A   L  +L+ T  + E+++    + LE+   +    R  
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098

Query: 531  EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
            +   E L    EQ++ A+    T+ E E+      KL  +A     T + L+ E+  A E
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158

Query: 581  SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
              + L+ +H   + EV  ++ ++  L +   AVL +  + ++ ELE+L  QL +  E   
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1217

Query: 638  ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
               + L++    + +I    L D+  +  + +Q   L  E+    +K+E  Q F K  + 
Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277

Query: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
              ++  +  ++    L+     +K  ++      + +E   LR    E  TL  +    +
Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337

Query: 746  QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
             E   + E  E+  +++  + +E+ A++EA    L+ +++  E   +      +E +   
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1391

Query: 806  LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
               ++ + ++ V  +E     E   D +QQ   + EE+++ R +   +E   +   ++ +
Sbjct: 1392 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1441

Query: 866  EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
                  L++++++   + + E   + +  A  E   LQ +     + +           A
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1487

Query: 926  ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
            +  +  E  E+   ++ ++ +  ++ ++EL+ R+   +E  ++K   +  L E    L+ 
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1543

Query: 986  EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
            + E+   R R+ E+     RA  VQ             +    R AE  +     SF E+
Sbjct: 1544 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1588

Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
            +  +             E S QE+ +   +  + +E+  RA Q +E ++ ++E     +E
Sbjct: 1589 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1628

Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
            +   R Q++A       + +  V Q +   + E +K            +EE  +E ++  
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1677

Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
            + E Q ++ +E  ++   K   L  G  Q+ ++ E                   L+ E  
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1723

Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
              +++     + E E   LQ         ++ +   L KV  E   LL      SK   +
Sbjct: 1724 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1775

Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
            +      E  ++ L  E   F  +  +   L  +    K +    + L +     Q  E 
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1831

Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
            E +++     + E T    EAEI   +K     RL+ ++E        ++      ++D 
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891

Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
            +  +   + ++K  D  +E   + G+ E+T        + + Q+EEE+  +  S   A A
Sbjct: 1892 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1939

Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
             + EL     RI    E+T  SK         Q     ++E+                E 
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
               Q +   +  E +  K +E  +   +   E  +++ L+          E K     + 
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059

Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
            ++     +T    QS+ D++   +  A R        ++    E  +  RQ    E ++Q
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119

Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
              E Q       QA   ++ ++ E +   + Q E   L ++ A  + ++     +E   R
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179

Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
            ++  +E EL  L+ QL     +K  L  EL+    +       + +VEE+ F  +    +
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239

Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
               +   I +  R  + +  +   + L E  +    V E   R        S  +Q +A 
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2292

Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
            L   +E + + +  + E+  +   +++   +        +   +++ ++  EL+Q   R 
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2344

Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
                  +  + E++   ++   Q   ++ LEA      E S++ E  K+   E+ R   R
Sbjct: 2345 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398

Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
             +++A    K  EE+ E+LH    A ++    +                 E Q Q+    
Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2444

Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
             +RL + +        ELE E++++Q+E +LL  + E M+      ++QLLQET+ L + 
Sbjct: 2445 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2494

Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
             L         +D L ++    E  +E++ ++  +L Q++  +   LR++ Q  ++Q+E+
Sbjct: 2495 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543

Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
             R+ L    E+A  R+HE +   +  Q+  QQL          E Q R+ E+L   L E+
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2590

Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
              +  E L   E+  R     +EE+   +          + +  T     D     A EA
Sbjct: 2591 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2640

Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
            +PE S +  L+ +  A   +E  I + EE
Sbjct: 2641 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2668



 Score =  140 bits (353), Expect = 2e-32
 Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)

Query: 424  QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
            QE   +LE     L  ++ Q  V MK  L  Q + +  ++           +RS+S  T 
Sbjct: 866  QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 914

Query: 484  NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
               + +    A++ L +  Q      +   +  G   E++   +R+        S   +Q
Sbjct: 915  RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 967

Query: 544  IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
            + ++ +  A++ES+     + +S ++D++ ++  A E+R           T ++++L + 
Sbjct: 968  LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1012

Query: 604  EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
            ++       R+AE Q  +AE+E L   +  L +  E++  L E       +  E     L
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1069

Query: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
             +   +Q+  L     +K++T+          +  L     +LK+ Q             
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129

Query: 712  SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
            +  +++  Q    Q   + LR E +    + + +Q+   + ++  ++ +E+   L E++ 
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189

Query: 772  QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
             + A+  + + E + L   L+ +   S +    +L   + +      +++I+ + + +++
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1242

Query: 831  DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
             +++Q  Q   L EEIE+        ++  +     +++    L+  K  LE   +  + 
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1301

Query: 888  EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
              K K+++ +E +  + ++  T   + +++  +   F++ETL   E  E+    L E+  
Sbjct: 1302 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1355

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
              +RE+L   +   +   QL + H +     E E K L+Q  ++  +R RE   +    +
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1414

Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
              ++Q    Q+    +  +   +R AE +         E S++ +E+++    + +    
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1465

Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
            +Q       L       +LRA   +E  + QK     ++E+   ++Q E+QR   + V  
Sbjct: 1466 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517

Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
                +       EK +AL +L+E  + A+E + +    E+++  Q+++     Q + +  
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1575

Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
                    +LQ   +       Q   S+  E+   A   E      +   +     E+ E
Sbjct: 1576 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628

Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
             +  R++++  +     L  +   +   L   +    K   ++    + +  E+ + + E
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
                 +  Q    E      + +L++ Q+L + + E +  E +  +  L+++L   ++  
Sbjct: 1689 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1743

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
             A     QKR +  +E      +  +  V+  S A+      S  +K+       +G F 
Sbjct: 1744 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797

Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
             + EE   ++ L  E + Q QL EE A    +   A A++    +++   E T    +A 
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1853

Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
               ++++     ++   +   FQ             + L ++  +H            DI
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1891

Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
             E    +   S+    + K  +   +RQ    E  + ++ AS +     +   ++    +
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951

Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
            R       A + LR     ++E  R+ Q   +EE +R   +   + S+  E   + + + 
Sbjct: 1952 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006

Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
             LEE+E LK      R       + S+ Q Q   E      Q E +   F    KE+EL 
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066

Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
            +  + E    + L  E    R A ++A    ++   E  ++   VEE         L +S
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2120

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
            ++ Q+ A    ++ AE   K    E   R   E  ++     +D        +++ T  +
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
              ++ Q L        E D + + L+     RL+A   +     S+   +L   +V   E
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239

Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
            L +   R + +     L+ ++  +  L EE+   +Q+A E ++        A  + L E 
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299

Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
             + ++  + +++ +E + A      L+AE + +Q+++EL   Q   ++ +   + QQL +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359

Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
            ET+   +        +LE+  +AE+++              +D Q+  K  E ++ E++ 
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2418

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
            R     QEK T +  L  Q Q  +   E++R+ + E     E E++  QQE + L  QLK
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2472

Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
                     E QT + EQL     ++T    +  LS++     + +R   IE+ + ++ +
Sbjct: 2473 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2518

Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
            L Q  +  A   ++ + R+     + +  L  S+E   + + +A   + RK++E+  LE+
Sbjct: 2519 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578

Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
            Q  Q  E L  +N+ +++    LE Q + +    +E+
Sbjct: 2579 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615



 Score =  122 bits (306), Expect = 7e-27
 Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)

Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
            A E    ++ + + QAE + +    K +  L  + E+    L   +     L  +LE+  
Sbjct: 1016 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1069

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
              +  +L+++   + ++ + ++ + L I+ +  A      H    K AQ +     E++ 
Sbjct: 1070 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1127

Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
                + KL+ Q +        +   + +R  +   E L          R+ E+E+  E +
Sbjct: 1128 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1181

Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
             +L +    +  +T +    L +    L++  +   A+ L A  Q      E++  M   
Sbjct: 1182 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1237

Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
            L ++     QL QE   L  ++R  E VE+ Q   +  +N   D+      EL++V  + 
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1291

Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
             L+ + +    K   ++G  S+I    +L T   +L +  S     +++  +++++ +  
Sbjct: 1292 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350

Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
             +      Q++    +++ E  V AAL  Q QL      AK         +E E   +Q 
Sbjct: 1351 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1395

Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
              Q   +R +E   D       I E   Q+ +   + I  K  Q E AE++ L  E+++ 
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455

Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
             ++  LE  E+++                            G   EL+ALRA +   +A+
Sbjct: 1456 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1488

Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
                +E+AE+L+ ++  +       + +L S+V+     A+EK   L+  +E  +Q  + 
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548

Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
                    ++ ++    Q    L+ +  +   ++  K A   +   Q E S +E    ++
Sbjct: 1549 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1604

Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
            Q  E+ E+  +  A AE    E+    E   LK    + ++L  EE    K++ Q    K
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664

Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
            +             A   A + RE+   +                    +EG  ++  +A
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1711

Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
                 +     LRA   +G Q   L E   +  +  +      +Q  E  L + +A +  
Sbjct: 1712 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766

Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
            + + K            K + + EAE     +  E  +  R     A +Q  L E     
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826

Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
                 E        A+G    L+   +    E +A  E L++     A +R  L E  A 
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886

Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
            H A +  R   L++  +SE   Q+ L+E  ++Q++    +++ E+ ++K          S
Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1933

Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
             EK     AEL+ EL + +   E TL++  K   ELEA R                 A E
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1979

Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
            +++ RE +  ++K  A   +  R  +   EE+E LK  +E  ++   +      +Q QL 
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039

Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
             E+ QK    E +   +  Q  E+     ELQ  L+ E+  + ++    +  R       
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
             A++Q+     QSR  +   + LK+  ++  +  ++      +L  E E+      Q  Q
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154

Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
               + +Q     ++  ++   +  ++  +++ ++  L+ QLEE   Q   LD E QRL+ 
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214

Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
               E  +Q  + EE+  S R+  + L++               L+ +IE E +      L
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2254

Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
            I  +   T     L+   +K++ VA +   L   A E  +     +ED +  Q  + E +
Sbjct: 2255 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2311

Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
            L+         E+   V  +T   +  E LL+Q  EL    ++  +E  D   M  +L E
Sbjct: 2312 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2359

Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
            + + +++T           L      +  +++E E        + ++  RAE  A+ ++ 
Sbjct: 2360 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
            +AE   + L +T     E VTL
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTL 2430



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)

Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
            LL  LEQ  QE+         C      +  +SE++ +  Q+     R +   R    ++
Sbjct: 968  LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014

Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
            P++E  +   +Q+++Q      E+  +      L  +  +EK++     S  A T + EL
Sbjct: 1015 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1067

Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
            E TL  + + ++ L A  LE K KT  + +     A E  ++ E Q    +         
Sbjct: 1068 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1125

Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
            E  K  L+ L+   E+Q+     L   L   +++    QQ+   +R +   +  E   + 
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1184

Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
            LE  Q +L    VR RE+      L   RE    L A LQ +    +    +P  D  + 
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1243

Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
            +++QL ++ + + E+    EK +      +Q +   KD ++   T + + E      KK 
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303

Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
             ++QS  E + ++  + R    +L  L  Q ++ I +  ++ E E     + R    + L
Sbjct: 1304 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362

Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
             E    +L   R    + +   + + +    AK ++          E   +  +Q+ + +
Sbjct: 1363 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418

Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
              +LQ L Q +   +Q +     A +   + ++E I  + LQL+    Q+G     +   
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478

Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
             +     E   RQ  E    +  Q+ +E    R   ++L  +++   +  A R+      
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1536

Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
                  ++A  A      +E E   + ++ L+ + + AEAE+   +A     +     S 
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596

Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
              EHV + +     LR E+ R+A
Sbjct: 1597 QEEHVAVAQ-----LREEAERRA 1614



 Score = 35.8 bits (81), Expect = 0.86
 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)

Query: 4    EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
            +E+ ++L+  K ++AQ         QR  +++ Q     S   ++ K R    S+    A
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399

Query: 52   HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
              D    + Q  E+      R E     + T+++TL    + + H+     E  +E+   
Sbjct: 2400 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2458

Query: 111  ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
             +    E           K   L  EE   V      Q  Q         +  L  ++  
Sbjct: 2459 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508

Query: 171  IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
            IE+   +LE++      +  Q  +E +   +Q +    +L A++++ARR + E       
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568

Query: 231  LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
              E+ Q+L+ Q +Q +               +LL  + Q L  Q QL E+ H
Sbjct: 2569 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2605



 Score = 35.0 bits (79), Expect = 1.5
 Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)

Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
            +QLN+    LQ  +++    KV +   E+ RDL   ++ I  L +D + +K  R  + EQ
Sbjct: 410  EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 469

Query: 2352 LNEVIEKLQQELANI 2366
            +   + +L + L  I
Sbjct: 470  MYRRVYRLHERLVAI 484


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  191 bits (486), Expect = 9e-48
 Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)

Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
            +++  EE   D +Q+   +  + Q+ +Q++E   QA  RQ E     + +++EEI+ +  
Sbjct: 1404 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1463

Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
            QL     QR   + E    +  R   EE EA K+ +    E+L  ++++ S   Q   + 
Sbjct: 1464 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1517

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
            + E+  +   E E  R+ +    + L   R   ++A  RL +  +E  +      ET   
Sbjct: 1518 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1574

Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
                   RS++++  +     +E  A ++  + EEH  V                     
Sbjct: 1575 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1607

Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
            +++ EE    +Q+   +  A  E + E E  +L  N + RL+   E++ +  S   ++ E
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667

Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
              K    E  RE+ R+ +   ++++ +E   + L ++ +  E  A +   AE  +     
Sbjct: 1668 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1724

Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
            E    E+Q Q   + + RL++E   A+ + QELEAE  +++ E E+L             
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784

Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
               + K+ ++AEAG   ++L +E  +L     E + Q +   +D  +Q    E  + E++
Sbjct: 1785 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843

Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
            +   E  + K    + L+++    E + E++R+  +++A  R    +   Q    +E++L
Sbjct: 1844 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899

Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
                        Q R+     + L+ +     + L  + Q++ +I       EK      
Sbjct: 1900 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946

Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
            ELE  L      + DT +  E        +A+ E + + QL AE     R+A +R +K +
Sbjct: 1947 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1998

Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
               EE   Q +  L    EEV++L  ++E  ++      QE  ++ +L ++  +K   A 
Sbjct: 1999 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054

Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
            +++ A + Q +     +  Q +Q+++  +DQL  +              ++Q + +    
Sbjct: 2055 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111

Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
             + +EE   L +  E Q +     Q   ++ R+E  +   E   + Q E A + QK + +
Sbjct: 2112 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2168

Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
            A     E +  K   +  + +K  +EQ       E+T ++  L+ET+ + N L +EL  L
Sbjct: 2169 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2216

Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
            K E     + +S  E    SV V ++ LSK K  +E       L+  +N   F   EE  
Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2275

Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
            K   +  E   L + +  +A+  +L +     +D+ +Q     +ML++K+  +Q+    K
Sbjct: 2276 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2330

Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
              A L+ Q Q E  QE A+  Q+++   ++      Q   +       R+ E+ ++   L
Sbjct: 2331 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389

Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
             LR++E+                  E    ++H + +  +E+V + +   +++++   + 
Sbjct: 2390 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2449

Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
            ++L E   + +REKEK +  Q+ ++L+  +E   + ++     E +AL+   ++ K  L 
Sbjct: 2450 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2507

Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
                     K K E+L ++ + K   +       Q+ + Q R  L  + E+    + E E
Sbjct: 2508 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2567

Query: 2756 TEVQESKK 2763
              V+  ++
Sbjct: 2568 EGVRRKQE 2575



 Score =  167 bits (424), Expect = 1e-40
 Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)

Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
            PE       + S L+  + KL +  S ++  LE  K     +     R  Q A E L+  
Sbjct: 1058 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1112

Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
            EE         + +E  AV  +  E      + +K   + + Q+ T   D L  EL  A 
Sbjct: 1113 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1160

Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
               QE+    QQ   ER++   +     A+     Q +L +T+   +E  ++  Q    R
Sbjct: 1161 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1217

Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
            +        L+ D   +  +   +    +  + +  +Q QAL +++E+  + ++E Q   
Sbjct: 1218 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1276

Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
            +++   +   E+Q +  + QL+ V      P+ Q  SE   +E   L  H  E T   S+
Sbjct: 1277 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1336

Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
                       I+  +E + ++E   R  EQ         Q+ E+R+    VEA      
Sbjct: 1337 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1377

Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
               E   + + QAER+A +   R ++E+   EE     +++  +  EE+QQL    E + 
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1437

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
            +    + +  E+     ++++  + L ++ ++      +  L    A+  +E E +  Q 
Sbjct: 1438 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1496

Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
             E+  +L++Q         ++++++  R  E ++   +  +    R ++  ++ L E+  
Sbjct: 1497 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1545

Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
            +LQ                 +EEA+    Q +V  A ++  ALE    +A  E+   +  
Sbjct: 1546 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1588

Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
              E   ++ +      SL+ E  +V +++   E       +   + + E E  L    LK
Sbjct: 1589 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1641

Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
            + E                  L  RL Q E     K L   +  KQ ++ + +    G+ 
Sbjct: 1642 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683

Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
            E + ++++ +  Q++ +++  A   +Q +L A QE  +       + +E E+   Q   Q
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1734

Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
            L E+EL     + +A T +  ELE+++ ++      L+  K + E   ++  EK K+ LE
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1794

Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
                 E    ++  +E  R     E  K   +L    EE       EA R  AE +A   
Sbjct: 1795 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1847

Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
            E    K +AE   +E   +   +  L +D +        Q   H A+ +E+L+ L K  +
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907

Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
            +E++  K          +    E L +K S   A+     L++               I+
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1956

Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
             N +    S+E  E+ +    ++   +E    E  +   + ++  E   R+   A+    
Sbjct: 1957 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 2012

Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
            EE   LKA ++  R       +E +   +LA   A    Q  E   + +     Q +  T
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072

Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
              Q   +  + RGE +E+A  +          A   E  +V +  E+  S  +    +++
Sbjct: 2073 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2121

Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
             +   E+ +A     ++ + L  + + +  R A+   ++   +  +D   E      +  
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181

Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
            L +++ +     T    L  TD     N L++ +Q    E   A     + +      R 
Sbjct: 2182 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2239

Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
             + E+  L A++    R + L+ +  +++  QE  E     K  Q+ E    LS     A
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2294

Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
              L         Q++  +EKM+  ++++    T+L+ E  L  Q K L + +A RL+   
Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2354

Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
            +     L  +T       E ++ R+L+ + E E+ KL      R++ R +E+ +  +   
Sbjct: 2355 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2414

Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
            E   ++ L    L  Q+K  L ++ + I+ Q+  +DA+   E    LE +     ++ ++
Sbjct: 2415 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2472

Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
             ++ S   +  +    LQ +    QS   L  +D L + ++ +E++ +++ +L  +    
Sbjct: 2473 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2530

Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
             ++ + +  + +QQME++RQ   + + + +EA     +    ++ K E+LQ+  +++RQQ
Sbjct: 2531 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2587

Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
               L  E QRL+  +Q  ++Q
Sbjct: 2588 EELLAEENQRLREQLQLLEEQ 2608



 Score =  158 bits (399), Expect = 1e-37
 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)

Query: 153  SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
            +PT    +E  L GK  ++  L+   LE+++    V  GT+G ++ L+  E  +K+   +
Sbjct: 1064 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1122

Query: 207  ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
               L       A+L++ R + +     F  L ++   +Q++  + QQ      +      
Sbjct: 1123 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1182

Query: 258  STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
               A LL+  Q +L      Q++LE+    L  Y++  +      ++LQ+  +  E  Q 
Sbjct: 1183 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1239

Query: 314  KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
              + +S   +E++++++ ++EE+        +K  E +         + + + Q+V    
Sbjct: 1240 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1295

Query: 372  EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
            +++ +       K +    S  +E   L     EL     +  +F ++ ++RME+E +R 
Sbjct: 1296 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1354

Query: 430  LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
             EQ RAE                 L E + Q   Q ++E         EE+  R +  ++
Sbjct: 1355 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1414

Query: 473  NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
               +  S   + E+  +L   +  E+  K +   + +    +++EE+ ++   LE     
Sbjct: 1415 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1471

Query: 522  ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
                  E  AL+ + E+   +   ++E+ +R R+ + ++  +  +A   L++   +KAE 
Sbjct: 1472 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1529

Query: 576  VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
             +A E ++ L    EL+ +AE    +++   +E+ +     L+    S EAEL+  R   
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1587

Query: 630  LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
              S  E+ ++L+  L+ EH + + +L++      +QQ +    + E  +++E  Q + + 
Sbjct: 1588 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1644

Query: 688  LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
             +  + Q   E+++ K L Q+              E +K+ E   +E + +G   EQ V+
Sbjct: 1645 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1689

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            + +L  + LEKQ +  E   Q++ A   AE  +++         L+  T   +++R +  
Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1737

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
            + +      +  ++E     ++ ++L+ +  ++  E+           E+ R+T   +++
Sbjct: 1738 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1791

Query: 856  NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
              E     ++EL EE A L  + ++        E+   +Q  E +     KL A+ E   
Sbjct: 1792 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1851

Query: 902  LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
            L+      +K K +  +      ED+ F    LE  E   +   ++ E+L ++ K    E
Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1909

Query: 955  LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
            L ++   + + L+Q+      + EE+ +LK   E+ +    ELE+ +   R+    +  +
Sbjct: 1910 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965

Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
            +  + L+      +     R    +  +V KS   E +   + K + E +   +   +E 
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025

Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
              L           L+  Q +   +LQ E   +    +Q +  LQ   Q+        + 
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2079

Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
            +DQ+R   E  + +A    +E  + A+ E  +  +++ + E      +E           
Sbjct: 2080 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2138

Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
              KL+K   +E +   Q   + L +      + E + +  E              Q  R 
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2184

Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
            + Q  QE + TL  ++ E  ++  +L   L ++  + T+  +         + E E  S+
Sbjct: 2185 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2237

Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
              QM  L  +   +  +++   L+D + T+  L+E+ ++++ +      +S   Q+    
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297

Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
             Q  E ++          L++++QAV E+T       L      + +  A+R       +
Sbjct: 2298 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2357

Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
             + +            +E     + LE + Q QLE       + + +A     E+SR   
Sbjct: 2358 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2401

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
              E  A   +  A    E+ +  E+   +     QT E    +   + + L + + E  +
Sbjct: 2402 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2461

Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
            E      +   +    + + T+ +E   ++ T  ++QS   E   S +   R +   + +
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2519

Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
            LE +        Q+L  + Q  QQ  E  RQ  +  ME  R  Q + +E ++R   +L Q
Sbjct: 2520 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2579

Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
              +     E L++E  + L E+L+ L++    +LA  E++      ++    NG +
Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2635



 Score =  149 bits (376), Expect = 5e-35
 Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)

Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
            A E++  +R I E  DI  +LE    C +  +  L     + +  RE   R  E  KA+A
Sbjct: 980  AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1035

Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
                 G    +L  E EK++    E    A  +R +L+  +  LE     QV     +  
Sbjct: 1036 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1089

Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
            EK   +  + +  Q  E+ L    + L E QA+     E +  +  ++KL  Q +   P 
Sbjct: 1090 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1149

Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
            F  + + + R  +++   L+++  ++  E+   +E++ + ++     + + + R RELEQ
Sbjct: 1150 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208

Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
             L      +++  D       +A+     + Q+QA   A  +  +E    E+ L    EE
Sbjct: 1209 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1261

Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
            +E   E+V++         K+    +++ E +   +K  +E +    K+    S  +   
Sbjct: 1262 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1315

Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
                   +IQE        +E  T   Q +K  +         E +R +E + E L   Q
Sbjct: 1316 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1358

Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
               +R R  E+E     +EK Q++LA    +    A   ++E    + Q +VV  E+ A+
Sbjct: 1359 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1413

Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
            + Q +         K  ++E   ++ Q ++ E+ +  R+ E+ E+               
Sbjct: 1414 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1449

Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
             S+ + E E+ +    L++ E Q          +G +  L  R  + E+       E  +
Sbjct: 1450 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1502

Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
              +Q++D  Q + Q E E+  +     +   E++ A   + +++L+A +E  +  +  + 
Sbjct: 1503 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1561

Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
              +   +  ++   +  E EL S  ++   + ++LE  + E H ++   +E+ E   +  
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1621

Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
             E E+   E ++ LE  + K  E            +++S    E  K   E        G
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1681

Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
               E +A+R   +A + EL   ++ AE   ++ L  E  +  L+ +  Q        +E+
Sbjct: 1682 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1739

Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
            L+ L++E     Q     E++ A +   + + L+    ++ +     S+S ++ Q L   
Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1796

Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
            AG    L  E +      E  +   Q  E+    Q   A  +L  +   I E   LK E 
Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1856

Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
             +A   LKE            +  E   +  LA  +A+Q R +                 
Sbjct: 1857 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901

Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
               +SDS  +  +G+               L     F+ A+ G+ E          +A D
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961

Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
            +   K +  L A      Q+ +  E    + E+   + ++  E    +RKA +  +  LK
Sbjct: 1962 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2019

Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
              + + +  RE    +S++  +   +   + L A               LQQ   +E+SV
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2079

Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
            L                   A  + E  A  +   V     L+Q  +EQ     + QAA 
Sbjct: 2080 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139

Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
            E L+K   +      QA  A +  ++      ++ +K +++ L    Q +Q ++  ++++
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2198

Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
            L     +   L E+L   K    E   + +Q + EL  +++ Q + L +L+A R+E +++
Sbjct: 2199 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2256

Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
               +   ++T    Q+++ +++   E+         E A+L +  E D  +   L   + 
Sbjct: 2257 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2316

Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
             +K + +Q          LL+QQK+L  E  ++++  +     QL+EE QG         
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2376

Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
             R LE+    E  K+R+ EMS    R E +     + ++  G+   R  L +++ +    
Sbjct: 2377 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436

Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
              E+Q+Q      E     I EL  E EK          K + +QT QQ +  ++ Q  +
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2496

Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
            ++  +E+++  + ++ + + ++K+E L        Q+  EE+++Q  +++ E QRL   M
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2556

Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
            +E ++++ E EE    ++   Q L +
Sbjct: 2557 EEARRRQHEAEEGVRRKQEELQQLEQ 2582



 Score =  146 bits (369), Expect = 3e-34
 Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)

Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
            L+       Q++   +  ++ +RE  RQ+Q   E ++        CQ   ++ ++     
Sbjct: 1227 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286

Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
              QL    ++                +E VI  Y D +T       L  + I+  ++ + 
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346

Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
            R+E+E   A         RL E+EA  ++ ++  E  ++ K   + EA  ++Q++ +E  
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406

Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
            +  +  ++ Q Q   ++++LQ+  ++ E +++ +  +    E+ +     E+  +R Q +
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466

Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
            A E+Q    E   + L  +A + E ++   Q+E ++L +Q+      Q  S+ + +   +
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1520

Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
            LA+ +K + +   E    K++  + ++E   + E+ E R+R+ E    + + V+ +T Q+
Sbjct: 1521 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576

Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
              +      R  F    A+ E SL+       QL+ E +   +++ E     E+ E+  E
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636

Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
              + K  E  +L +Q E   ++ +    E E++ +  + +  + G A             
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1683

Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
                      +E+ V   +L EQ  + Q+QL   T  + +  + ELIR        L ++
Sbjct: 1684 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1725

Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
             E      E++ + L E + +LQ+E A   QK       L  E   ++ +++V++A K  
Sbjct: 1726 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1777

Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
             E++  + +E+    K  L+    +  +L +E   L+   E  ++ + + E         
Sbjct: 1778 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834

Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
                      AI   ++ K E E+ L E     + L+ L     F  +  EE       +
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894

Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
            +E RL QL     A D EL +    ++D   Q +     ++++I+ L+   E+  A    
Sbjct: 1895 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1947

Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
             +++L  ++  A+      T+ S+ +      L   R+ +L ++      R  E E +V 
Sbjct: 1948 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1995

Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
            +   SL  E+E      K  LE+ ++L    K      ++ RE+ ++ S + +++ +   
Sbjct: 1996 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2047

Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
            +              + L+AE    KA   + ++K ++LQ+ L  +++ +  L+ +    
Sbjct: 2048 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2090

Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
            R    EA+E     E+E      +V+E+++         +      +  +   K +    
Sbjct: 2091 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150

Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
              +   + A ++    ++   E+  +   Q   +K +  QEL    +       + ET+ 
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2204

Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
             K        LL EE   LKA      +++ S + E   S   Q  E+    +       
Sbjct: 2205 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2250

Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
                      I +E R      +  T  F ++    ++ V  E  ++    +      E 
Sbjct: 2251 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2294

Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
              ++Q++E  L +++A        K L  KMQ  +EA    +              LL  
Sbjct: 2295 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2338

Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
            Q+   +E++  L   + ++      +  G    LE   Q Q +E  A  E L+   R + 
Sbjct: 2339 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2395

Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
            +S  QA  A+ + ++   + E+  EK  +   E   Q+K + +  ++++       A  L
Sbjct: 2396 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2452

Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
            +E        +AEL+ E  + KL+ E  L      LK  E   ++ +    E   L  + 
Sbjct: 2453 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2499

Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
             SE+    + +  +E+EKAKL +  + +  + + L+   + Q+Q+       +EQ++Q L
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2552

Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
              S +  E++R  ++A+      +E+ + LE Q      LL  E  R+RE    L+ +  
Sbjct: 2553 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2610

Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
                H++  ++     ++      D L     + E +HS
Sbjct: 2611 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2649



 Score =  142 bits (359), Expect = 5e-33
 Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)

Query: 417  DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
            DI  ++E    R + +LR  LD+   ++  Q    +  Q  AQ          E+E   +
Sbjct: 995  DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1042

Query: 477  SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
              + ++   +++  +   + A   L  +L+ T  + E+++    + LE+   +    R  
Sbjct: 1043 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1102

Query: 531  EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
            +   E L    EQ++ A+    T+ E E+      KL  +A     T + L+ E+  A E
Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1162

Query: 581  SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
              + L+ +H   + EV  ++ ++  L +   AVL +  + ++ ELE+L  QL +  E   
Sbjct: 1163 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1221

Query: 638  ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
               + L++    + +I    L D+  +  + +Q   L  E+    +K+E  Q F K  + 
Sbjct: 1222 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1281

Query: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
              ++  +  ++    L+     +K  ++      + +E   LR    E  TL  +    +
Sbjct: 1282 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1341

Query: 746  QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
             E   + E  E+  +++  + +E+ A++EA    L+ +++  E   +      +E +   
Sbjct: 1342 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1395

Query: 806  LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
               ++ + ++ V  +E     E   D +QQ   + EE+++ R +   +E   +   ++ +
Sbjct: 1396 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1445

Query: 866  EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
                  L++++++   + + E   + +  A  E   LQ +     + +           A
Sbjct: 1446 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1491

Query: 926  ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
            +  +  E  E+   ++ ++ +  ++ ++EL+ R+   +E  ++K   +  L E    L+ 
Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1547

Query: 986  EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
            + E+   R R+ E+     RA  VQ             +    R AE  +     SF E+
Sbjct: 1548 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1592

Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
            +  +             E S QE+ +   +  + +E+  RA Q +E ++ ++E     +E
Sbjct: 1593 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1632

Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
            +   R Q++A       + +  V Q +   + E +K            +EE  +E ++  
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1681

Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
            + E Q ++ +E  ++   K   L  G  Q+ ++ E                   L+ E  
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1727

Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
              +++     + E E   LQ         ++ +   L KV  E   LL      SK   +
Sbjct: 1728 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1779

Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
            +      E  ++ L  E   F  +  +   L  +    K +    + L +     Q  E 
Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1835

Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
            E +++     + E T    EAEI   +K     RL+ ++E        ++      ++D 
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895

Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
            +  +   + ++K  D  +E   + G+ E+T        + + Q+EEE+  +  S   A A
Sbjct: 1896 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1943

Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
             + EL     RI    E+T  SK         Q     ++E+                E 
Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003

Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
               Q +   +  E +  K +E  +   +   E  +++ L+          E K     + 
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2063

Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
            ++     +T    QS+ D++   +  A R        ++    E  +  RQ    E ++Q
Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123

Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
              E Q       QA   ++ ++ E +   + Q E   L ++ A  + ++     +E   R
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183

Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
            ++  +E EL  L+ QL     +K  L  EL+    +       + +VEE+ F  +    +
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243

Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
               +   I +  R  + +  +   + L E  +    V E   R        S  +Q +A 
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2296

Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
            L   +E + + +  + E+  +   +++   +        +   +++ ++  EL+Q   R 
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2348

Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
                  +  + E++   ++   Q   ++ LEA      E S++ E  K+   E+ R   R
Sbjct: 2349 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2402

Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
             +++A    K  EE+ E+LH    A ++    +                 E Q Q+    
Sbjct: 2403 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2448

Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
             +RL + +        ELE E++++Q+E +LL  + E M+      ++QLLQET+ L + 
Sbjct: 2449 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2498

Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
             L         +D L ++    E  +E++ ++  +L Q++  +   LR++ Q  ++Q+E+
Sbjct: 2499 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547

Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
             R+ L    E+A  R+HE +   +  Q+  QQL          E Q R+ E+L   L E+
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2594

Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
              +  E L   E+  R     +EE+   +          + +  T     D     A EA
Sbjct: 2595 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2644

Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
            +PE S +  L+ +  A   +E  I + EE
Sbjct: 2645 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2672



 Score =  140 bits (353), Expect = 2e-32
 Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)

Query: 424  QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
            QE   +LE     L  ++ Q  V MK  L  Q + +  ++           +RS+S  T 
Sbjct: 870  QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 918

Query: 484  NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
               + +    A++ L +  Q      +   +  G   E++   +R+        S   +Q
Sbjct: 919  RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 971

Query: 544  IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
            + ++ +  A++ES+     + +S ++D++ ++  A E+R           T ++++L + 
Sbjct: 972  LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1016

Query: 604  EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
            ++       R+AE Q  +AE+E L   +  L +  E++  L E       +  E     L
Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1073

Query: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
             +   +Q+  L     +K++T+          +  L     +LK+ Q             
Sbjct: 1074 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1133

Query: 712  SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
            +  +++  Q    Q   + LR E +    + + +Q+   + ++  ++ +E+   L E++ 
Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1193

Query: 772  QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
             + A+  + + E + L   L+ +   S +    +L   + +      +++I+ + + +++
Sbjct: 1194 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1246

Query: 831  DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
             +++Q  Q   L EEIE+        ++  +     +++    L+  K  LE   +  + 
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1305

Query: 888  EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
              K K+++ +E +  + ++  T   + +++  +   F++ETL   E  E+    L E+  
Sbjct: 1306 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1359

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
              +RE+L   +   +   QL + H +     E E K L+Q  ++  +R RE   +    +
Sbjct: 1360 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1418

Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
              ++Q    Q+    +  +   +R AE +         E S++ +E+++    + +    
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1469

Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
            +Q       L       +LRA   +E  + QK     ++E+   ++Q E+QR   + V  
Sbjct: 1470 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521

Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
                +       EK +AL +L+E  + A+E + +    E+++  Q+++     Q + +  
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1579

Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
                    +LQ   +       Q   S+  E+   A   E      +   +     E+ E
Sbjct: 1580 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1632

Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
             +  R++++  +     L  +   +   L   +    K   ++    + +  E+ + + E
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1692

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
                 +  Q    E      + +L++ Q+L + + E +  E +  +  L+++L   ++  
Sbjct: 1693 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1747

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
             A     QKR +  +E      +  +  V+  S A+      S  +K+       +G F 
Sbjct: 1748 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1801

Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
             + EE   ++ L  E + Q QL EE A    +   A A++    +++   E T    +A 
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1857

Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
               ++++     ++   +   FQ             + L ++  +H            DI
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1895

Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
             E    +   S+    + K  +   +RQ    E  + ++ AS +     +   ++    +
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955

Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
            R       A + LR     ++E  R+ Q   +EE +R   +   + S+  E   + + + 
Sbjct: 1956 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010

Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
             LEE+E LK      R       + S+ Q Q   E      Q E +   F    KE+EL 
Sbjct: 2011 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070

Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
            +  + E    + L  E    R A ++A    ++   E  ++   VEE         L +S
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2124

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
            ++ Q+ A    ++ AE   K    E   R   E  ++     +D        +++ T  +
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184

Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
              ++ Q L        E D + + L+     RL+A   +     S+   +L   +V   E
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243

Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
            L +   R + +     L+ ++  +  L EE+   +Q+A E ++        A  + L E 
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303

Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
             + ++  + +++ +E + A      L+AE + +Q+++EL   Q   ++ +   + QQL +
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363

Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
            ET+   +        +LE+  +AE+++              +D Q+  K  E ++ E++ 
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2422

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
            R     QEK T +  L  Q Q  +   E++R+ + E     E E++  QQE + L  QLK
Sbjct: 2423 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2476

Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
                     E QT + EQL     ++T    +  LS++     + +R   IE+ + ++ +
Sbjct: 2477 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2522

Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
            L Q  +  A   ++ + R+     + +  L  S+E   + + +A   + RK++E+  LE+
Sbjct: 2523 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2582

Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
            Q  Q  E L  +N+ +++    LE Q + +    +E+
Sbjct: 2583 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619



 Score =  122 bits (306), Expect = 7e-27
 Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)

Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
            A E    ++ + + QAE + +    K +  L  + E+    L   +     L  +LE+  
Sbjct: 1020 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1073

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
              +  +L+++   + ++ + ++ + L I+ +  A      H    K AQ +     E++ 
Sbjct: 1074 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1131

Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
                + KL+ Q +        +   + +R  +   E L          R+ E+E+  E +
Sbjct: 1132 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1185

Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
             +L +    +  +T +    L +    L++  +   A+ L A  Q      E++  M   
Sbjct: 1186 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1241

Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
            L ++     QL QE   L  ++R  E VE+ Q   +  +N   D+      EL++V  + 
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1295

Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
             L+ + +    K   ++G  S+I    +L T   +L +  S     +++  +++++ +  
Sbjct: 1296 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1354

Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
             +      Q++    +++ E  V AAL  Q QL      AK         +E E   +Q 
Sbjct: 1355 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1399

Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
              Q   +R +E   D       I E   Q+ +   + I  K  Q E AE++ L  E+++ 
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459

Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
             ++  LE  E+++                            G   EL+ALRA +   +A+
Sbjct: 1460 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1492

Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
                +E+AE+L+ ++  +       + +L S+V+     A+EK   L+  +E  +Q  + 
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552

Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
                    ++ ++    Q    L+ +  +   ++  K A   +   Q E S +E    ++
Sbjct: 1553 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1608

Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
            Q  E+ E+  +  A AE    E+    E   LK    + ++L  EE    K++ Q    K
Sbjct: 1609 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1668

Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
            +             A   A + RE+   +                    +EG  ++  +A
Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1715

Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
                 +     LRA   +G Q   L E   +  +  +      +Q  E  L + +A +  
Sbjct: 1716 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1770

Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
            + + K            K + + EAE     +  E  +  R     A +Q  L E     
Sbjct: 1771 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1830

Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
                 E        A+G    L+   +    E +A  E L++     A +R  L E  A 
Sbjct: 1831 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1890

Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
            H A +  R   L++  +SE   Q+ L+E  ++Q++    +++ E+ ++K          S
Sbjct: 1891 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1937

Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
             EK     AEL+ EL + +   E TL++  K   ELEA R                 A E
Sbjct: 1938 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1983

Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
            +++ RE +  ++K  A   +  R  +   EE+E LK  +E  ++   +      +Q QL 
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043

Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
             E+ QK    E +   +  Q  E+     ELQ  L+ E+  + ++    +  R       
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098

Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
             A++Q+     QSR  +   + LK+  ++  +  ++      +L  E E+      Q  Q
Sbjct: 2099 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2158

Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
               + +Q     ++  ++   +  ++  +++ ++  L+ QLEE   Q   LD E QRL+ 
Sbjct: 2159 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2218

Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
               E  +Q  + EE+  S R+  + L++               L+ +IE E +      L
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2258

Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
            I  +   T     L+   +K++ VA +   L   A E  +     +ED +  Q  + E +
Sbjct: 2259 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2315

Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
            L+         E+   V  +T   +  E LL+Q  EL    ++  +E  D   M  +L E
Sbjct: 2316 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2363

Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
            + + +++T           L      +  +++E E        + ++  RAE  A+ ++ 
Sbjct: 2364 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412

Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
            +AE   + L +T     E VTL
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTL 2434



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)

Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
            LL  LEQ  QE+         C      +  +SE++ +  Q+     R +   R    ++
Sbjct: 972  LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1018

Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
            P++E  +   +Q+++Q      E+  +      L  +  +EK++     S  A T + EL
Sbjct: 1019 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1071

Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
            E TL  + + ++ L A  LE K KT  + +     A E  ++ E Q    +         
Sbjct: 1072 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1129

Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
            E  K  L+ L+   E+Q+     L   L   +++    QQ+   +R +   +  E   + 
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1188

Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
            LE  Q +L    VR RE+      L   RE    L A LQ +    +    +P  D  + 
Sbjct: 1189 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1247

Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
            +++QL ++ + + E+    EK +      +Q +   KD ++   T + + E      KK 
Sbjct: 1248 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1307

Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
             ++QS  E + ++  + R    +L  L  Q ++ I +  ++ E E     + R    + L
Sbjct: 1308 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366

Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
             E    +L   R    + +   + + +    AK ++          E   +  +Q+ + +
Sbjct: 1367 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422

Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
              +LQ L Q +   +Q +     A +   + ++E I  + LQL+    Q+G     +   
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482

Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
             +     E   RQ  E    +  Q+ +E    R   ++L  +++   +  A R+      
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1540

Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
                  ++A  A      +E E   + ++ L+ + + AEAE+   +A     +     S 
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600

Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
              EHV + +     LR E+ R+A
Sbjct: 1601 QEEHVAVAQ-----LREEAERRA 1618



 Score = 35.8 bits (81), Expect = 0.86
 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)

Query: 4    EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
            +E+ ++L+  K ++AQ         QR  +++ Q     S   ++ K R    S+    A
Sbjct: 2344 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2403

Query: 52   HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
              D    + Q  E+      R E     + T+++TL    + + H+     E  +E+   
Sbjct: 2404 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2462

Query: 111  ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
             +    E           K   L  EE   V      Q  Q         +  L  ++  
Sbjct: 2463 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2512

Query: 171  IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
            IE+   +LE++      +  Q  +E +   +Q +    +L A++++ARR + E       
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572

Query: 231  LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
              E+ Q+L+ Q +Q +               +LL  + Q L  Q QL E+ H
Sbjct: 2573 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2609



 Score = 35.0 bits (79), Expect = 1.5
 Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)

Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
            +QLN+    LQ  +++    KV +   E+ RDL   ++ I  L +D + +K  R  + EQ
Sbjct: 414  EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 473

Query: 2352 LNEVIEKLQQELANI 2366
            +   + +L + L  I
Sbjct: 474  MYRRVYRLHERLVAI 488


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  191 bits (486), Expect = 9e-48
 Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)

Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
            +++  EE   D +Q+   +  + Q+ +Q++E   QA  RQ E     + +++EEI+ +  
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459

Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
            QL     QR   + E    +  R   EE EA K+ +    E+L  ++++ S   Q   + 
Sbjct: 1460 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1513

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
            + E+  +   E E  R+ +    + L   R   ++A  RL +  +E  +      ET   
Sbjct: 1514 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1570

Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
                   RS++++  +     +E  A ++  + EEH  V                     
Sbjct: 1571 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1603

Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
            +++ EE    +Q+   +  A  E + E E  +L  N + RL+   E++ +  S   ++ E
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
              K    E  RE+ R+ +   ++++ +E   + L ++ +  E  A +   AE  +     
Sbjct: 1664 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720

Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
            E    E+Q Q   + + RL++E   A+ + QELEAE  +++ E E+L             
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
               + K+ ++AEAG   ++L +E  +L     E + Q +   +D  +Q    E  + E++
Sbjct: 1781 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839

Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
            +   E  + K    + L+++    E + E++R+  +++A  R    +   Q    +E++L
Sbjct: 1840 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
                        Q R+     + L+ +     + L  + Q++ +I       EK      
Sbjct: 1896 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942

Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
            ELE  L      + DT +  E        +A+ E + + QL AE     R+A +R +K +
Sbjct: 1943 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1994

Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
               EE   Q +  L    EEV++L  ++E  ++      QE  ++ +L ++  +K   A 
Sbjct: 1995 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050

Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
            +++ A + Q +     +  Q +Q+++  +DQL  +              ++Q + +    
Sbjct: 2051 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107

Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
             + +EE   L +  E Q +     Q   ++ R+E  +   E   + Q E A + QK + +
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2164

Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
            A     E +  K   +  + +K  +EQ       E+T ++  L+ET+ + N L +EL  L
Sbjct: 2165 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2212

Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
            K E     + +S  E    SV V ++ LSK K  +E       L+  +N   F   EE  
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2271

Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
            K   +  E   L + +  +A+  +L +     +D+ +Q     +ML++K+  +Q+    K
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2326

Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
              A L+ Q Q E  QE A+  Q+++   ++      Q   +       R+ E+ ++   L
Sbjct: 2327 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385

Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
             LR++E+                  E    ++H + +  +E+V + +   +++++   + 
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445

Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
            ++L E   + +REKEK +  Q+ ++L+  +E   + ++     E +AL+   ++ K  L 
Sbjct: 2446 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503

Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
                     K K E+L ++ + K   +       Q+ + Q R  L  + E+    + E E
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563

Query: 2756 TEVQESKK 2763
              V+  ++
Sbjct: 2564 EGVRRKQE 2571



 Score =  167 bits (424), Expect = 1e-40
 Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)

Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
            PE       + S L+  + KL +  S ++  LE  K     +     R  Q A E L+  
Sbjct: 1054 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1108

Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
            EE         + +E  AV  +  E      + +K   + + Q+ T   D L  EL  A 
Sbjct: 1109 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1156

Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
               QE+    QQ   ER++   +     A+     Q +L +T+   +E  ++  Q    R
Sbjct: 1157 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1213

Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
            +        L+ D   +  +   +    +  + +  +Q QAL +++E+  + ++E Q   
Sbjct: 1214 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272

Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
            +++   +   E+Q +  + QL+ V      P+ Q  SE   +E   L  H  E T   S+
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1332

Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
                       I+  +E + ++E   R  EQ         Q+ E+R+    VEA      
Sbjct: 1333 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1373

Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
               E   + + QAER+A +   R ++E+   EE     +++  +  EE+QQL    E + 
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
            +    + +  E+     ++++  + L ++ ++      +  L    A+  +E E +  Q 
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1492

Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
             E+  +L++Q         ++++++  R  E ++   +  +    R ++  ++ L E+  
Sbjct: 1493 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1541

Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
            +LQ                 +EEA+    Q +V  A ++  ALE    +A  E+   +  
Sbjct: 1542 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584

Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
              E   ++ +      SL+ E  +V +++   E       +   + + E E  L    LK
Sbjct: 1585 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1637

Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
            + E                  L  RL Q E     K L   +  KQ ++ + +    G+ 
Sbjct: 1638 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679

Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
            E + ++++ +  Q++ +++  A   +Q +L A QE  +       + +E E+   Q   Q
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1730

Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
            L E+EL     + +A T +  ELE+++ ++      L+  K + E   ++  EK K+ LE
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790

Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
                 E    ++  +E  R     E  K   +L    EE       EA R  AE +A   
Sbjct: 1791 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1843

Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
            E    K +AE   +E   +   +  L +D +        Q   H A+ +E+L+ L K  +
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
            +E++  K          +    E L +K S   A+     L++               I+
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1952

Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
             N +    S+E  E+ +    ++   +E    E  +   + ++  E   R+   A+    
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 2008

Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
            EE   LKA ++  R       +E +   +LA   A    Q  E   + +     Q +  T
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
              Q   +  + RGE +E+A  +          A   E  +V +  E+  S  +    +++
Sbjct: 2069 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2117

Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
             +   E+ +A     ++ + L  + + +  R A+   ++   +  +D   E      +  
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177

Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
            L +++ +     T    L  TD     N L++ +Q    E   A     + +      R 
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235

Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
             + E+  L A++    R + L+ +  +++  QE  E     K  Q+ E    LS     A
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2290

Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
              L         Q++  +EKM+  ++++    T+L+ E  L  Q K L + +A RL+   
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2350

Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
            +     L  +T       E ++ R+L+ + E E+ KL      R++ R +E+ +  +   
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410

Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
            E   ++ L    L  Q+K  L ++ + I+ Q+  +DA+   E    LE +     ++ ++
Sbjct: 2411 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468

Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
             ++ S   +  +    LQ +    QS   L  +D L + ++ +E++ +++ +L  +    
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2526

Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
             ++ + +  + +QQME++RQ   + + + +EA     +    ++ K E+LQ+  +++RQQ
Sbjct: 2527 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583

Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
               L  E QRL+  +Q  ++Q
Sbjct: 2584 EELLAEENQRLREQLQLLEEQ 2604



 Score =  158 bits (399), Expect = 1e-37
 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)

Query: 153  SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
            +PT    +E  L GK  ++  L+   LE+++    V  GT+G ++ L+  E  +K+   +
Sbjct: 1060 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118

Query: 207  ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
               L       A+L++ R + +     F  L ++   +Q++  + QQ      +      
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178

Query: 258  STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
               A LL+  Q +L      Q++LE+    L  Y++  +      ++LQ+  +  E  Q 
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1235

Query: 314  KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
              + +S   +E++++++ ++EE+        +K  E +         + + + Q+V    
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1291

Query: 372  EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
            +++ +       K +    S  +E   L     EL     +  +F ++ ++RME+E +R 
Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1350

Query: 430  LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
             EQ RAE                 L E + Q   Q ++E         EE+  R +  ++
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410

Query: 473  NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
               +  S   + E+  +L   +  E+  K +   + +    +++EE+ ++   LE     
Sbjct: 1411 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467

Query: 522  ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
                  E  AL+ + E+   +   ++E+ +R R+ + ++  +  +A   L++   +KAE 
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1525

Query: 576  VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
             +A E ++ L    EL+ +AE    +++   +E+ +     L+    S EAEL+  R   
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1583

Query: 630  LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
              S  E+ ++L+  L+ EH + + +L++      +QQ +    + E  +++E  Q + + 
Sbjct: 1584 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640

Query: 688  LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
             +  + Q   E+++ K L Q+              E +K+ E   +E + +G   EQ V+
Sbjct: 1641 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1685

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            + +L  + LEKQ +  E   Q++ A   AE  +++         L+  T   +++R +  
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1733

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
            + +      +  ++E     ++ ++L+ +  ++  E+           E+ R+T   +++
Sbjct: 1734 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787

Query: 856  NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
              E     ++EL EE A L  + ++        E+   +Q  E +     KL A+ E   
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847

Query: 902  LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
            L+      +K K +  +      ED+ F    LE  E   +   ++ E+L ++ K    E
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1905

Query: 955  LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
            L ++   + + L+Q+      + EE+ +LK   E+ +    ELE+ +   R+    +  +
Sbjct: 1906 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961

Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
            +  + L+      +     R    +  +V KS   E +   + K + E +   +   +E 
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021

Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
              L           L+  Q +   +LQ E   +    +Q +  LQ   Q+        + 
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2075

Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
            +DQ+R   E  + +A    +E  + A+ E  +  +++ + E      +E           
Sbjct: 2076 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134

Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
              KL+K   +E +   Q   + L +      + E + +  E              Q  R 
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2180

Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
            + Q  QE + TL  ++ E  ++  +L   L ++  + T+  +         + E E  S+
Sbjct: 2181 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2233

Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
              QM  L  +   +  +++   L+D + T+  L+E+ ++++ +      +S   Q+    
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293

Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
             Q  E ++          L++++QAV E+T       L      + +  A+R       +
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353

Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
             + +            +E     + LE + Q QLE       + + +A     E+SR   
Sbjct: 2354 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2397

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
              E  A   +  A    E+ +  E+   +     QT E    +   + + L + + E  +
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457

Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
            E      +   +    + + T+ +E   ++ T  ++QS   E   S +   R +   + +
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2515

Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
            LE +        Q+L  + Q  QQ  E  RQ  +  ME  R  Q + +E ++R   +L Q
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575

Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
              +     E L++E  + L E+L+ L++    +LA  E++      ++    NG +
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631



 Score =  149 bits (376), Expect = 5e-35
 Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)

Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
            A E++  +R I E  DI  +LE    C +  +  L     + +  RE   R  E  KA+A
Sbjct: 976  AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1031

Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
                 G    +L  E EK++    E    A  +R +L+  +  LE     QV     +  
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1085

Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
            EK   +  + +  Q  E+ L    + L E QA+     E +  +  ++KL  Q +   P 
Sbjct: 1086 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1145

Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
            F  + + + R  +++   L+++  ++  E+   +E++ + ++     + + + R RELEQ
Sbjct: 1146 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
             L      +++  D       +A+     + Q+QA   A  +  +E    E+ L    EE
Sbjct: 1205 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1257

Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
            +E   E+V++         K+    +++ E +   +K  +E +    K+    S  +   
Sbjct: 1258 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1311

Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
                   +IQE        +E  T   Q +K  +         E +R +E + E L   Q
Sbjct: 1312 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1354

Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
               +R R  E+E     +EK Q++LA    +    A   ++E    + Q +VV  E+ A+
Sbjct: 1355 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1409

Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
            + Q +         K  ++E   ++ Q ++ E+ +  R+ E+ E+               
Sbjct: 1410 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1445

Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
             S+ + E E+ +    L++ E Q          +G +  L  R  + E+       E  +
Sbjct: 1446 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1498

Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
              +Q++D  Q + Q E E+  +     +   E++ A   + +++L+A +E  +  +  + 
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1557

Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
              +   +  ++   +  E EL S  ++   + ++LE  + E H ++   +E+ E   +  
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617

Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
             E E+   E ++ LE  + K  E            +++S    E  K   E        G
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677

Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
               E +A+R   +A + EL   ++ AE   ++ L  E  +  L+ +  Q        +E+
Sbjct: 1678 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735

Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
            L+ L++E     Q     E++ A +   + + L+    ++ +     S+S ++ Q L   
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1792

Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
            AG    L  E +      E  +   Q  E+    Q   A  +L  +   I E   LK E 
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852

Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
             +A   LKE            +  E   +  LA  +A+Q R +                 
Sbjct: 1853 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897

Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
               +SDS  +  +G+               L     F+ A+ G+ E          +A D
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
            +   K +  L A      Q+ +  E    + E+   + ++  E    +RKA +  +  LK
Sbjct: 1958 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015

Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
              + + +  RE    +S++  +   +   + L A               LQQ   +E+SV
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075

Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
            L                   A  + E  A  +   V     L+Q  +EQ     + QAA 
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135

Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
            E L+K   +      QA  A +  ++      ++ +K +++ L    Q +Q ++  ++++
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2194

Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
            L     +   L E+L   K    E   + +Q + EL  +++ Q + L +L+A R+E +++
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2252

Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
               +   ++T    Q+++ +++   E+         E A+L +  E D  +   L   + 
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312

Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
             +K + +Q          LL+QQK+L  E  ++++  +     QL+EE QG         
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372

Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
             R LE+    E  K+R+ EMS    R E +     + ++  G+   R  L +++ +    
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432

Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
              E+Q+Q      E     I EL  E EK          K + +QT QQ +  ++ Q  +
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492

Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
            ++  +E+++  + ++ + + ++K+E L        Q+  EE+++Q  +++ E QRL   M
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552

Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
            +E ++++ E EE    ++   Q L +
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQ 2578



 Score =  146 bits (369), Expect = 3e-34
 Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)

Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
            L+       Q++   +  ++ +RE  RQ+Q   E ++        CQ   ++ ++     
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282

Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
              QL    ++                +E VI  Y D +T       L  + I+  ++ + 
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342

Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
            R+E+E   A         RL E+EA  ++ ++  E  ++ K   + EA  ++Q++ +E  
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402

Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
            +  +  ++ Q Q   ++++LQ+  ++ E +++ +  +    E+ +     E+  +R Q +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462

Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
            A E+Q    E   + L  +A + E ++   Q+E ++L +Q+      Q  S+ + +   +
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1516

Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
            LA+ +K + +   E    K++  + ++E   + E+ E R+R+ E    + + V+ +T Q+
Sbjct: 1517 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
              +      R  F    A+ E SL+       QL+ E +   +++ E     E+ E+  E
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
              + K  E  +L +Q E   ++ +    E E++ +  + +  + G A             
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1679

Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
                      +E+ V   +L EQ  + Q+QL   T  + +  + ELIR        L ++
Sbjct: 1680 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1721

Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
             E      E++ + L E + +LQ+E A   QK       L  E   ++ +++V++A K  
Sbjct: 1722 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1773

Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
             E++  + +E+    K  L+    +  +L +E   L+   E  ++ + + E         
Sbjct: 1774 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830

Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
                      AI   ++ K E E+ L E     + L+ L     F  +  EE       +
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890

Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
            +E RL QL     A D EL +    ++D   Q +     ++++I+ L+   E+  A    
Sbjct: 1891 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1943

Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
             +++L  ++  A+      T+ S+ +      L   R+ +L ++      R  E E +V 
Sbjct: 1944 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1991

Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
            +   SL  E+E      K  LE+ ++L    K      ++ RE+ ++ S + +++ +   
Sbjct: 1992 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2043

Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
            +              + L+AE    KA   + ++K ++LQ+ L  +++ +  L+ +    
Sbjct: 2044 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086

Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
            R    EA+E     E+E      +V+E+++         +      +  +   K +    
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
              +   + A ++    ++   E+  +   Q   +K +  QEL    +       + ET+ 
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2200

Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
             K        LL EE   LKA      +++ S + E   S   Q  E+    +       
Sbjct: 2201 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2246

Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
                      I +E R      +  T  F ++    ++ V  E  ++    +      E 
Sbjct: 2247 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2290

Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
              ++Q++E  L +++A        K L  KMQ  +EA    +              LL  
Sbjct: 2291 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2334

Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
            Q+   +E++  L   + ++      +  G    LE   Q Q +E  A  E L+   R + 
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2391

Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
            +S  QA  A+ + ++   + E+  EK  +   E   Q+K + +  ++++       A  L
Sbjct: 2392 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2448

Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
            +E        +AEL+ E  + KL+ E  L      LK  E   ++ +    E   L  + 
Sbjct: 2449 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2495

Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
             SE+    + +  +E+EKAKL +  + +  + + L+   + Q+Q+       +EQ++Q L
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2548

Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
              S +  E++R  ++A+      +E+ + LE Q      LL  E  R+RE    L+ +  
Sbjct: 2549 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606

Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
                H++  ++     ++      D L     + E +HS
Sbjct: 2607 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645



 Score =  142 bits (359), Expect = 5e-33
 Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)

Query: 417  DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
            DI  ++E    R + +LR  LD+   ++  Q    +  Q  AQ          E+E   +
Sbjct: 991  DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1038

Query: 477  SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
              + ++   +++  +   + A   L  +L+ T  + E+++    + LE+   +    R  
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098

Query: 531  EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
            +   E L    EQ++ A+    T+ E E+      KL  +A     T + L+ E+  A E
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158

Query: 581  SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
              + L+ +H   + EV  ++ ++  L +   AVL +  + ++ ELE+L  QL +  E   
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1217

Query: 638  ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
               + L++    + +I    L D+  +  + +Q   L  E+    +K+E  Q F K  + 
Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277

Query: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
              ++  +  ++    L+     +K  ++      + +E   LR    E  TL  +    +
Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337

Query: 746  QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
             E   + E  E+  +++  + +E+ A++EA    L+ +++  E   +      +E +   
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1391

Query: 806  LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
               ++ + ++ V  +E     E   D +QQ   + EE+++ R +   +E   +   ++ +
Sbjct: 1392 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1441

Query: 866  EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
                  L++++++   + + E   + +  A  E   LQ +     + +           A
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1487

Query: 926  ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
            +  +  E  E+   ++ ++ +  ++ ++EL+ R+   +E  ++K   +  L E    L+ 
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1543

Query: 986  EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
            + E+   R R+ E+     RA  VQ             +    R AE  +     SF E+
Sbjct: 1544 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1588

Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
            +  +             E S QE+ +   +  + +E+  RA Q +E ++ ++E     +E
Sbjct: 1589 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1628

Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
            +   R Q++A       + +  V Q +   + E +K            +EE  +E ++  
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1677

Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
            + E Q ++ +E  ++   K   L  G  Q+ ++ E                   L+ E  
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1723

Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
              +++     + E E   LQ         ++ +   L KV  E   LL      SK   +
Sbjct: 1724 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1775

Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
            +      E  ++ L  E   F  +  +   L  +    K +    + L +     Q  E 
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1831

Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
            E +++     + E T    EAEI   +K     RL+ ++E        ++      ++D 
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891

Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
            +  +   + ++K  D  +E   + G+ E+T        + + Q+EEE+  +  S   A A
Sbjct: 1892 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1939

Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
             + EL     RI    E+T  SK         Q     ++E+                E 
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
               Q +   +  E +  K +E  +   +   E  +++ L+          E K     + 
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059

Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
            ++     +T    QS+ D++   +  A R        ++    E  +  RQ    E ++Q
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119

Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
              E Q       QA   ++ ++ E +   + Q E   L ++ A  + ++     +E   R
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179

Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
            ++  +E EL  L+ QL     +K  L  EL+    +       + +VEE+ F  +    +
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239

Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
               +   I +  R  + +  +   + L E  +    V E   R        S  +Q +A 
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2292

Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
            L   +E + + +  + E+  +   +++   +        +   +++ ++  EL+Q   R 
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2344

Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
                  +  + E++   ++   Q   ++ LEA      E S++ E  K+   E+ R   R
Sbjct: 2345 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398

Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
             +++A    K  EE+ E+LH    A ++    +                 E Q Q+    
Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2444

Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
             +RL + +        ELE E++++Q+E +LL  + E M+      ++QLLQET+ L + 
Sbjct: 2445 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2494

Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
             L         +D L ++    E  +E++ ++  +L Q++  +   LR++ Q  ++Q+E+
Sbjct: 2495 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543

Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
             R+ L    E+A  R+HE +   +  Q+  QQL          E Q R+ E+L   L E+
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2590

Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
              +  E L   E+  R     +EE+   +          + +  T     D     A EA
Sbjct: 2591 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2640

Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
            +PE S +  L+ +  A   +E  I + EE
Sbjct: 2641 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2668



 Score =  140 bits (353), Expect = 2e-32
 Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)

Query: 424  QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
            QE   +LE     L  ++ Q  V MK  L  Q + +  ++           +RS+S  T 
Sbjct: 866  QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 914

Query: 484  NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
               + +    A++ L +  Q      +   +  G   E++   +R+        S   +Q
Sbjct: 915  RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 967

Query: 544  IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
            + ++ +  A++ES+     + +S ++D++ ++  A E+R           T ++++L + 
Sbjct: 968  LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1012

Query: 604  EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
            ++       R+AE Q  +AE+E L   +  L +  E++  L E       +  E     L
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1069

Query: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
             +   +Q+  L     +K++T+          +  L     +LK+ Q             
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129

Query: 712  SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
            +  +++  Q    Q   + LR E +    + + +Q+   + ++  ++ +E+   L E++ 
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189

Query: 772  QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
             + A+  + + E + L   L+ +   S +    +L   + +      +++I+ + + +++
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1242

Query: 831  DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
             +++Q  Q   L EEIE+        ++  +     +++    L+  K  LE   +  + 
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1301

Query: 888  EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
              K K+++ +E +  + ++  T   + +++  +   F++ETL   E  E+    L E+  
Sbjct: 1302 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1355

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
              +RE+L   +   +   QL + H +     E E K L+Q  ++  +R RE   +    +
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1414

Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
              ++Q    Q+    +  +   +R AE +         E S++ +E+++    + +    
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1465

Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
            +Q       L       +LRA   +E  + QK     ++E+   ++Q E+QR   + V  
Sbjct: 1466 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517

Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
                +       EK +AL +L+E  + A+E + +    E+++  Q+++     Q + +  
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1575

Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
                    +LQ   +       Q   S+  E+   A   E      +   +     E+ E
Sbjct: 1576 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628

Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
             +  R++++  +     L  +   +   L   +    K   ++    + +  E+ + + E
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
                 +  Q    E      + +L++ Q+L + + E +  E +  +  L+++L   ++  
Sbjct: 1689 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1743

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
             A     QKR +  +E      +  +  V+  S A+      S  +K+       +G F 
Sbjct: 1744 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797

Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
             + EE   ++ L  E + Q QL EE A    +   A A++    +++   E T    +A 
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1853

Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
               ++++     ++   +   FQ             + L ++  +H            DI
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1891

Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
             E    +   S+    + K  +   +RQ    E  + ++ AS +     +   ++    +
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951

Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
            R       A + LR     ++E  R+ Q   +EE +R   +   + S+  E   + + + 
Sbjct: 1952 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006

Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
             LEE+E LK      R       + S+ Q Q   E      Q E +   F    KE+EL 
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066

Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
            +  + E    + L  E    R A ++A    ++   E  ++   VEE         L +S
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2120

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
            ++ Q+ A    ++ AE   K    E   R   E  ++     +D        +++ T  +
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
              ++ Q L        E D + + L+     RL+A   +     S+   +L   +V   E
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239

Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
            L +   R + +     L+ ++  +  L EE+   +Q+A E ++        A  + L E 
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299

Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
             + ++  + +++ +E + A      L+AE + +Q+++EL   Q   ++ +   + QQL +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359

Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
            ET+   +        +LE+  +AE+++              +D Q+  K  E ++ E++ 
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2418

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
            R     QEK T +  L  Q Q  +   E++R+ + E     E E++  QQE + L  QLK
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2472

Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
                     E QT + EQL     ++T    +  LS++     + +R   IE+ + ++ +
Sbjct: 2473 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2518

Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
            L Q  +  A   ++ + R+     + +  L  S+E   + + +A   + RK++E+  LE+
Sbjct: 2519 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578

Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
            Q  Q  E L  +N+ +++    LE Q + +    +E+
Sbjct: 2579 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615



 Score =  122 bits (306), Expect = 7e-27
 Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)

Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
            A E    ++ + + QAE + +    K +  L  + E+    L   +     L  +LE+  
Sbjct: 1016 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1069

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
              +  +L+++   + ++ + ++ + L I+ +  A      H    K AQ +     E++ 
Sbjct: 1070 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1127

Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
                + KL+ Q +        +   + +R  +   E L          R+ E+E+  E +
Sbjct: 1128 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1181

Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
             +L +    +  +T +    L +    L++  +   A+ L A  Q      E++  M   
Sbjct: 1182 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1237

Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
            L ++     QL QE   L  ++R  E VE+ Q   +  +N   D+      EL++V  + 
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1291

Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
             L+ + +    K   ++G  S+I    +L T   +L +  S     +++  +++++ +  
Sbjct: 1292 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350

Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
             +      Q++    +++ E  V AAL  Q QL      AK         +E E   +Q 
Sbjct: 1351 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1395

Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
              Q   +R +E   D       I E   Q+ +   + I  K  Q E AE++ L  E+++ 
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455

Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
             ++  LE  E+++                            G   EL+ALRA +   +A+
Sbjct: 1456 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1488

Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
                +E+AE+L+ ++  +       + +L S+V+     A+EK   L+  +E  +Q  + 
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548

Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
                    ++ ++    Q    L+ +  +   ++  K A   +   Q E S +E    ++
Sbjct: 1549 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1604

Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
            Q  E+ E+  +  A AE    E+    E   LK    + ++L  EE    K++ Q    K
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664

Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
            +             A   A + RE+   +                    +EG  ++  +A
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1711

Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
                 +     LRA   +G Q   L E   +  +  +      +Q  E  L + +A +  
Sbjct: 1712 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766

Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
            + + K            K + + EAE     +  E  +  R     A +Q  L E     
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826

Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
                 E        A+G    L+   +    E +A  E L++     A +R  L E  A 
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886

Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
            H A +  R   L++  +SE   Q+ L+E  ++Q++    +++ E+ ++K          S
Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1933

Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
             EK     AEL+ EL + +   E TL++  K   ELEA R                 A E
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1979

Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
            +++ RE +  ++K  A   +  R  +   EE+E LK  +E  ++   +      +Q QL 
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039

Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
             E+ QK    E +   +  Q  E+     ELQ  L+ E+  + ++    +  R       
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
             A++Q+     QSR  +   + LK+  ++  +  ++      +L  E E+      Q  Q
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154

Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
               + +Q     ++  ++   +  ++  +++ ++  L+ QLEE   Q   LD E QRL+ 
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214

Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
               E  +Q  + EE+  S R+  + L++               L+ +IE E +      L
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2254

Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
            I  +   T     L+   +K++ VA +   L   A E  +     +ED +  Q  + E +
Sbjct: 2255 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2311

Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
            L+         E+   V  +T   +  E LL+Q  EL    ++  +E  D   M  +L E
Sbjct: 2312 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2359

Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
            + + +++T           L      +  +++E E        + ++  RAE  A+ ++ 
Sbjct: 2360 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
            +AE   + L +T     E VTL
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTL 2430



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)

Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
            LL  LEQ  QE+         C      +  +SE++ +  Q+     R +   R    ++
Sbjct: 968  LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014

Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
            P++E  +   +Q+++Q      E+  +      L  +  +EK++     S  A T + EL
Sbjct: 1015 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1067

Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
            E TL  + + ++ L A  LE K KT  + +     A E  ++ E Q    +         
Sbjct: 1068 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1125

Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
            E  K  L+ L+   E+Q+     L   L   +++    QQ+   +R +   +  E   + 
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1184

Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
            LE  Q +L    VR RE+      L   RE    L A LQ +    +    +P  D  + 
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1243

Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
            +++QL ++ + + E+    EK +      +Q +   KD ++   T + + E      KK 
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303

Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
             ++QS  E + ++  + R    +L  L  Q ++ I +  ++ E E     + R    + L
Sbjct: 1304 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362

Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
             E    +L   R    + +   + + +    AK ++          E   +  +Q+ + +
Sbjct: 1363 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418

Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
              +LQ L Q +   +Q +     A +   + ++E I  + LQL+    Q+G     +   
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478

Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
             +     E   RQ  E    +  Q+ +E    R   ++L  +++   +  A R+      
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1536

Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
                  ++A  A      +E E   + ++ L+ + + AEAE+   +A     +     S 
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596

Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
              EHV + +     LR E+ R+A
Sbjct: 1597 QEEHVAVAQ-----LREEAERRA 1614



 Score = 35.8 bits (81), Expect = 0.86
 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)

Query: 4    EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
            +E+ ++L+  K ++AQ         QR  +++ Q     S   ++ K R    S+    A
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399

Query: 52   HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
              D    + Q  E+      R E     + T+++TL    + + H+     E  +E+   
Sbjct: 2400 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2458

Query: 111  ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
             +    E           K   L  EE   V      Q  Q         +  L  ++  
Sbjct: 2459 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508

Query: 171  IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
            IE+   +LE++      +  Q  +E +   +Q +    +L A++++ARR + E       
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568

Query: 231  LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
              E+ Q+L+ Q +Q +               +LL  + Q L  Q QL E+ H
Sbjct: 2569 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2605



 Score = 35.0 bits (79), Expect = 1.5
 Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)

Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
            +QLN+    LQ  +++    KV +   E+ RDL   ++ I  L +D + +K  R  + EQ
Sbjct: 410  EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 469

Query: 2352 LNEVIEKLQQELANI 2366
            +   + +L + L  I
Sbjct: 470  MYRRVYRLHERLVAI 484


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  191 bits (486), Expect = 9e-48
 Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)

Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
            +++  EE   D +Q+   +  + Q+ +Q++E   QA  RQ E     + +++EEI+ +  
Sbjct: 1368 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1427

Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
            QL     QR   + E    +  R   EE EA K+ +    E+L  ++++ S   Q   + 
Sbjct: 1428 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1481

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
            + E+  +   E E  R+ +    + L   R   ++A  RL +  +E  +      ET   
Sbjct: 1482 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1538

Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
                   RS++++  +     +E  A ++  + EEH  V                     
Sbjct: 1539 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1571

Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
            +++ EE    +Q+   +  A  E + E E  +L  N + RL+   E++ +  S   ++ E
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631

Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
              K    E  RE+ R+ +   ++++ +E   + L ++ +  E  A +   AE  +     
Sbjct: 1632 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1688

Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
            E    E+Q Q   + + RL++E   A+ + QELEAE  +++ E E+L             
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748

Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
               + K+ ++AEAG   ++L +E  +L     E + Q +   +D  +Q    E  + E++
Sbjct: 1749 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807

Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
            +   E  + K    + L+++    E + E++R+  +++A  R    +   Q    +E++L
Sbjct: 1808 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863

Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
                        Q R+     + L+ +     + L  + Q++ +I       EK      
Sbjct: 1864 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910

Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
            ELE  L      + DT +  E        +A+ E + + QL AE     R+A +R +K +
Sbjct: 1911 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1962

Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
               EE   Q +  L    EEV++L  ++E  ++      QE  ++ +L ++  +K   A 
Sbjct: 1963 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018

Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
            +++ A + Q +     +  Q +Q+++  +DQL  +              ++Q + +    
Sbjct: 2019 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075

Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
             + +EE   L +  E Q +     Q   ++ R+E  +   E   + Q E A + QK + +
Sbjct: 2076 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2132

Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
            A     E +  K   +  + +K  +EQ       E+T ++  L+ET+ + N L +EL  L
Sbjct: 2133 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2180

Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
            K E     + +S  E    SV V ++ LSK K  +E       L+  +N   F   EE  
Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2239

Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
            K   +  E   L + +  +A+  +L +     +D+ +Q     +ML++K+  +Q+    K
Sbjct: 2240 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2294

Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
              A L+ Q Q E  QE A+  Q+++   ++      Q   +       R+ E+ ++   L
Sbjct: 2295 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353

Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
             LR++E+                  E    ++H + +  +E+V + +   +++++   + 
Sbjct: 2354 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2413

Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
            ++L E   + +REKEK +  Q+ ++L+  +E   + ++     E +AL+   ++ K  L 
Sbjct: 2414 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2471

Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
                     K K E+L ++ + K   +       Q+ + Q R  L  + E+    + E E
Sbjct: 2472 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2531

Query: 2756 TEVQESKK 2763
              V+  ++
Sbjct: 2532 EGVRRKQE 2539



 Score =  167 bits (424), Expect = 1e-40
 Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)

Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
            PE       + S L+  + KL +  S ++  LE  K     +     R  Q A E L+  
Sbjct: 1022 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1076

Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
            EE         + +E  AV  +  E      + +K   + + Q+ T   D L  EL  A 
Sbjct: 1077 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1124

Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
               QE+    QQ   ER++   +     A+     Q +L +T+   +E  ++  Q    R
Sbjct: 1125 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1181

Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
            +        L+ D   +  +   +    +  + +  +Q QAL +++E+  + ++E Q   
Sbjct: 1182 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1240

Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
            +++   +   E+Q +  + QL+ V      P+ Q  SE   +E   L  H  E T   S+
Sbjct: 1241 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1300

Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
                       I+  +E + ++E   R  EQ         Q+ E+R+    VEA      
Sbjct: 1301 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1341

Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
               E   + + QAER+A +   R ++E+   EE     +++  +  EE+QQL    E + 
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1401

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
            +    + +  E+     ++++  + L ++ ++      +  L    A+  +E E +  Q 
Sbjct: 1402 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1460

Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
             E+  +L++Q         ++++++  R  E ++   +  +    R ++  ++ L E+  
Sbjct: 1461 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1509

Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
            +LQ                 +EEA+    Q +V  A ++  ALE    +A  E+   +  
Sbjct: 1510 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1552

Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
              E   ++ +      SL+ E  +V +++   E       +   + + E E  L    LK
Sbjct: 1553 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1605

Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
            + E                  L  RL Q E     K L   +  KQ ++ + +    G+ 
Sbjct: 1606 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647

Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
            E + ++++ +  Q++ +++  A   +Q +L A QE  +       + +E E+   Q   Q
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1698

Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
            L E+EL     + +A T +  ELE+++ ++      L+  K + E   ++  EK K+ LE
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1758

Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
                 E    ++  +E  R     E  K   +L    EE       EA R  AE +A   
Sbjct: 1759 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1811

Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
            E    K +AE   +E   +   +  L +D +        Q   H A+ +E+L+ L K  +
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871

Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
            +E++  K          +    E L +K S   A+     L++               I+
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1920

Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
             N +    S+E  E+ +    ++   +E    E  +   + ++  E   R+   A+    
Sbjct: 1921 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 1976

Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
            EE   LKA ++  R       +E +   +LA   A    Q  E   + +     Q +  T
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036

Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
              Q   +  + RGE +E+A  +          A   E  +V +  E+  S  +    +++
Sbjct: 2037 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2085

Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
             +   E+ +A     ++ + L  + + +  R A+   ++   +  +D   E      +  
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145

Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
            L +++ +     T    L  TD     N L++ +Q    E   A     + +      R 
Sbjct: 2146 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2203

Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
             + E+  L A++    R + L+ +  +++  QE  E     K  Q+ E    LS     A
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2258

Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
              L         Q++  +EKM+  ++++    T+L+ E  L  Q K L + +A RL+   
Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2318

Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
            +     L  +T       E ++ R+L+ + E E+ KL      R++ R +E+ +  +   
Sbjct: 2319 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2378

Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
            E   ++ L    L  Q+K  L ++ + I+ Q+  +DA+   E    LE +     ++ ++
Sbjct: 2379 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2436

Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
             ++ S   +  +    LQ +    QS   L  +D L + ++ +E++ +++ +L  +    
Sbjct: 2437 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2494

Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
             ++ + +  + +QQME++RQ   + + + +EA     +    ++ K E+LQ+  +++RQQ
Sbjct: 2495 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2551

Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
               L  E QRL+  +Q  ++Q
Sbjct: 2552 EELLAEENQRLREQLQLLEEQ 2572



 Score =  158 bits (399), Expect = 1e-37
 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)

Query: 153  SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
            +PT    +E  L GK  ++  L+   LE+++    V  GT+G ++ L+  E  +K+   +
Sbjct: 1028 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1086

Query: 207  ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
               L       A+L++ R + +     F  L ++   +Q++  + QQ      +      
Sbjct: 1087 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1146

Query: 258  STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
               A LL+  Q +L      Q++LE+    L  Y++  +      ++LQ+  +  E  Q 
Sbjct: 1147 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1203

Query: 314  KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
              + +S   +E++++++ ++EE+        +K  E +         + + + Q+V    
Sbjct: 1204 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1259

Query: 372  EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
            +++ +       K +    S  +E   L     EL     +  +F ++ ++RME+E +R 
Sbjct: 1260 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1318

Query: 430  LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
             EQ RAE                 L E + Q   Q ++E         EE+  R +  ++
Sbjct: 1319 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1378

Query: 473  NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
               +  S   + E+  +L   +  E+  K +   + +    +++EE+ ++   LE     
Sbjct: 1379 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1435

Query: 522  ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
                  E  AL+ + E+   +   ++E+ +R R+ + ++  +  +A   L++   +KAE 
Sbjct: 1436 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1493

Query: 576  VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
             +A E ++ L    EL+ +AE    +++   +E+ +     L+    S EAEL+  R   
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1551

Query: 630  LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
              S  E+ ++L+  L+ EH + + +L++      +QQ +    + E  +++E  Q + + 
Sbjct: 1552 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1608

Query: 688  LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
             +  + Q   E+++ K L Q+              E +K+ E   +E + +G   EQ V+
Sbjct: 1609 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1653

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            + +L  + LEKQ +  E   Q++ A   AE  +++         L+  T   +++R +  
Sbjct: 1654 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1701

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
            + +      +  ++E     ++ ++L+ +  ++  E+           E+ R+T   +++
Sbjct: 1702 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1755

Query: 856  NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
              E     ++EL EE A L  + ++        E+   +Q  E +     KL A+ E   
Sbjct: 1756 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1815

Query: 902  LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
            L+      +K K +  +      ED+ F    LE  E   +   ++ E+L ++ K    E
Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1873

Query: 955  LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
            L ++   + + L+Q+      + EE+ +LK   E+ +    ELE+ +   R+    +  +
Sbjct: 1874 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929

Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
            +  + L+      +     R    +  +V KS   E +   + K + E +   +   +E 
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989

Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
              L           L+  Q +   +LQ E   +    +Q +  LQ   Q+        + 
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2043

Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
            +DQ+R   E  + +A    +E  + A+ E  +  +++ + E      +E           
Sbjct: 2044 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2102

Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
              KL+K   +E +   Q   + L +      + E + +  E              Q  R 
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2148

Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
            + Q  QE + TL  ++ E  ++  +L   L ++  + T+  +         + E E  S+
Sbjct: 2149 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2201

Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
              QM  L  +   +  +++   L+D + T+  L+E+ ++++ +      +S   Q+    
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261

Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
             Q  E ++          L++++QAV E+T       L      + +  A+R       +
Sbjct: 2262 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2321

Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
             + +            +E     + LE + Q QLE       + + +A     E+SR   
Sbjct: 2322 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2365

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
              E  A   +  A    E+ +  E+   +     QT E    +   + + L + + E  +
Sbjct: 2366 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2425

Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
            E      +   +    + + T+ +E   ++ T  ++QS   E   S +   R +   + +
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2483

Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
            LE +        Q+L  + Q  QQ  E  RQ  +  ME  R  Q + +E ++R   +L Q
Sbjct: 2484 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2543

Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
              +     E L++E  + L E+L+ L++    +LA  E++      ++    NG +
Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2599



 Score =  149 bits (376), Expect = 5e-35
 Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)

Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
            A E++  +R I E  DI  +LE    C +  +  L     + +  RE   R  E  KA+A
Sbjct: 944  AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 999

Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
                 G    +L  E EK++    E    A  +R +L+  +  LE     QV     +  
Sbjct: 1000 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1053

Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
            EK   +  + +  Q  E+ L    + L E QA+     E +  +  ++KL  Q +   P 
Sbjct: 1054 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1113

Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
            F  + + + R  +++   L+++  ++  E+   +E++ + ++     + + + R RELEQ
Sbjct: 1114 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172

Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
             L      +++  D       +A+     + Q+QA   A  +  +E    E+ L    EE
Sbjct: 1173 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1225

Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
            +E   E+V++         K+    +++ E +   +K  +E +    K+    S  +   
Sbjct: 1226 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1279

Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
                   +IQE        +E  T   Q +K  +         E +R +E + E L   Q
Sbjct: 1280 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1322

Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
               +R R  E+E     +EK Q++LA    +    A   ++E    + Q +VV  E+ A+
Sbjct: 1323 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1377

Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
            + Q +         K  ++E   ++ Q ++ E+ +  R+ E+ E+               
Sbjct: 1378 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1413

Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
             S+ + E E+ +    L++ E Q          +G +  L  R  + E+       E  +
Sbjct: 1414 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1466

Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
              +Q++D  Q + Q E E+  +     +   E++ A   + +++L+A +E  +  +  + 
Sbjct: 1467 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1525

Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
              +   +  ++   +  E EL S  ++   + ++LE  + E H ++   +E+ E   +  
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1585

Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
             E E+   E ++ LE  + K  E            +++S    E  K   E        G
Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1645

Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
               E +A+R   +A + EL   ++ AE   ++ L  E  +  L+ +  Q        +E+
Sbjct: 1646 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1703

Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
            L+ L++E     Q     E++ A +   + + L+    ++ +     S+S ++ Q L   
Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1760

Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
            AG    L  E +      E  +   Q  E+    Q   A  +L  +   I E   LK E 
Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1820

Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
             +A   LKE            +  E   +  LA  +A+Q R +                 
Sbjct: 1821 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865

Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
               +SDS  +  +G+               L     F+ A+ G+ E          +A D
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925

Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
            +   K +  L A      Q+ +  E    + E+   + ++  E    +RKA +  +  LK
Sbjct: 1926 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1983

Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
              + + +  RE    +S++  +   +   + L A               LQQ   +E+SV
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2043

Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
            L                   A  + E  A  +   V     L+Q  +EQ     + QAA 
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103

Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
            E L+K   +      QA  A +  ++      ++ +K +++ L    Q +Q ++  ++++
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2162

Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
            L     +   L E+L   K    E   + +Q + EL  +++ Q + L +L+A R+E +++
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2220

Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
               +   ++T    Q+++ +++   E+         E A+L +  E D  +   L   + 
Sbjct: 2221 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2280

Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
             +K + +Q          LL+QQK+L  E  ++++  +     QL+EE QG         
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340

Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
             R LE+    E  K+R+ EMS    R E +     + ++  G+   R  L +++ +    
Sbjct: 2341 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2400

Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
              E+Q+Q      E     I EL  E EK          K + +QT QQ +  ++ Q  +
Sbjct: 2401 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2460

Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
            ++  +E+++  + ++ + + ++K+E L        Q+  EE+++Q  +++ E QRL   M
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2520

Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
            +E ++++ E EE    ++   Q L +
Sbjct: 2521 EEARRRQHEAEEGVRRKQEELQQLEQ 2546



 Score =  146 bits (369), Expect = 3e-34
 Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)

Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
            L+       Q++   +  ++ +RE  RQ+Q   E ++        CQ   ++ ++     
Sbjct: 1191 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250

Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
              QL    ++                +E VI  Y D +T       L  + I+  ++ + 
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1310

Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
            R+E+E   A         RL E+EA  ++ ++  E  ++ K   + EA  ++Q++ +E  
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370

Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
            +  +  ++ Q Q   ++++LQ+  ++ E +++ +  +    E+ +     E+  +R Q +
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430

Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
            A E+Q    E   + L  +A + E ++   Q+E ++L +Q+      Q  S+ + +   +
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1484

Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
            LA+ +K + +   E    K++  + ++E   + E+ E R+R+ E    + + V+ +T Q+
Sbjct: 1485 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540

Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
              +      R  F    A+ E SL+       QL+ E +   +++ E     E+ E+  E
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600

Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
              + K  E  +L +Q E   ++ +    E E++ +  + +  + G A             
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1647

Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
                      +E+ V   +L EQ  + Q+QL   T  + +  + ELIR        L ++
Sbjct: 1648 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1689

Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
             E      E++ + L E + +LQ+E A   QK       L  E   ++ +++V++A K  
Sbjct: 1690 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1741

Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
             E++  + +E+    K  L+    +  +L +E   L+   E  ++ + + E         
Sbjct: 1742 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798

Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
                      AI   ++ K E E+ L E     + L+ L     F  +  EE       +
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858

Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
            +E RL QL     A D EL +    ++D   Q +     ++++I+ L+   E+  A    
Sbjct: 1859 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1911

Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
             +++L  ++  A+      T+ S+ +      L   R+ +L ++      R  E E +V 
Sbjct: 1912 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1959

Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
            +   SL  E+E      K  LE+ ++L    K      ++ RE+ ++ S + +++ +   
Sbjct: 1960 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2011

Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
            +              + L+AE    KA   + ++K ++LQ+ L  +++ +  L+ +    
Sbjct: 2012 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2054

Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
            R    EA+E     E+E      +V+E+++         +      +  +   K +    
Sbjct: 2055 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114

Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
              +   + A ++    ++   E+  +   Q   +K +  QEL    +       + ET+ 
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2168

Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
             K        LL EE   LKA      +++ S + E   S   Q  E+    +       
Sbjct: 2169 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2214

Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
                      I +E R      +  T  F ++    ++ V  E  ++    +      E 
Sbjct: 2215 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2258

Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
              ++Q++E  L +++A        K L  KMQ  +EA    +              LL  
Sbjct: 2259 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2302

Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
            Q+   +E++  L   + ++      +  G    LE   Q Q +E  A  E L+   R + 
Sbjct: 2303 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2359

Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
            +S  QA  A+ + ++   + E+  EK  +   E   Q+K + +  ++++       A  L
Sbjct: 2360 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2416

Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
            +E        +AEL+ E  + KL+ E  L      LK  E   ++ +    E   L  + 
Sbjct: 2417 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2463

Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
             SE+    + +  +E+EKAKL +  + +  + + L+   + Q+Q+       +EQ++Q L
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2516

Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
              S +  E++R  ++A+      +E+ + LE Q      LL  E  R+RE    L+ +  
Sbjct: 2517 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2574

Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
                H++  ++     ++      D L     + E +HS
Sbjct: 2575 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2613



 Score =  142 bits (359), Expect = 5e-33
 Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)

Query: 417  DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
            DI  ++E    R + +LR  LD+   ++  Q    +  Q  AQ          E+E   +
Sbjct: 959  DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1006

Query: 477  SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
              + ++   +++  +   + A   L  +L+ T  + E+++    + LE+   +    R  
Sbjct: 1007 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1066

Query: 531  EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
            +   E L    EQ++ A+    T+ E E+      KL  +A     T + L+ E+  A E
Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1126

Query: 581  SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
              + L+ +H   + EV  ++ ++  L +   AVL +  + ++ ELE+L  QL +  E   
Sbjct: 1127 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1185

Query: 638  ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
               + L++    + +I    L D+  +  + +Q   L  E+    +K+E  Q F K  + 
Sbjct: 1186 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1245

Query: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
              ++  +  ++    L+     +K  ++      + +E   LR    E  TL  +    +
Sbjct: 1246 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1305

Query: 746  QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
             E   + E  E+  +++  + +E+ A++EA    L+ +++  E   +      +E +   
Sbjct: 1306 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1359

Query: 806  LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
               ++ + ++ V  +E     E   D +QQ   + EE+++ R +   +E   +   ++ +
Sbjct: 1360 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1409

Query: 866  EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
                  L++++++   + + E   + +  A  E   LQ +     + +           A
Sbjct: 1410 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1455

Query: 926  ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
            +  +  E  E+   ++ ++ +  ++ ++EL+ R+   +E  ++K   +  L E    L+ 
Sbjct: 1456 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1511

Query: 986  EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
            + E+   R R+ E+     RA  VQ             +    R AE  +     SF E+
Sbjct: 1512 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1556

Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
            +  +             E S QE+ +   +  + +E+  RA Q +E ++ ++E     +E
Sbjct: 1557 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1596

Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
            +   R Q++A       + +  V Q +   + E +K            +EE  +E ++  
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1645

Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
            + E Q ++ +E  ++   K   L  G  Q+ ++ E                   L+ E  
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1691

Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
              +++     + E E   LQ         ++ +   L KV  E   LL      SK   +
Sbjct: 1692 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1743

Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
            +      E  ++ L  E   F  +  +   L  +    K +    + L +     Q  E 
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1799

Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
            E +++     + E T    EAEI   +K     RL+ ++E        ++      ++D 
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859

Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
            +  +   + ++K  D  +E   + G+ E+T        + + Q+EEE+  +  S   A A
Sbjct: 1860 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1907

Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
             + EL     RI    E+T  SK         Q     ++E+                E 
Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967

Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
               Q +   +  E +  K +E  +   +   E  +++ L+          E K     + 
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2027

Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
            ++     +T    QS+ D++   +  A R        ++    E  +  RQ    E ++Q
Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087

Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
              E Q       QA   ++ ++ E +   + Q E   L ++ A  + ++     +E   R
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147

Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
            ++  +E EL  L+ QL     +K  L  EL+    +       + +VEE+ F  +    +
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207

Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
               +   I +  R  + +  +   + L E  +    V E   R        S  +Q +A 
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2260

Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
            L   +E + + +  + E+  +   +++   +        +   +++ ++  EL+Q   R 
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2312

Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
                  +  + E++   ++   Q   ++ LEA      E S++ E  K+   E+ R   R
Sbjct: 2313 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2366

Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
             +++A    K  EE+ E+LH    A ++    +                 E Q Q+    
Sbjct: 2367 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2412

Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
             +RL + +        ELE E++++Q+E +LL  + E M+      ++QLLQET+ L + 
Sbjct: 2413 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2462

Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
             L         +D L ++    E  +E++ ++  +L Q++  +   LR++ Q  ++Q+E+
Sbjct: 2463 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511

Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
             R+ L    E+A  R+HE +   +  Q+  QQL          E Q R+ E+L   L E+
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2558

Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
              +  E L   E+  R     +EE+   +          + +  T     D     A EA
Sbjct: 2559 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2608

Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
            +PE S +  L+ +  A   +E  I + EE
Sbjct: 2609 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2636



 Score =  140 bits (353), Expect = 2e-32
 Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)

Query: 424  QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
            QE   +LE     L  ++ Q  V MK  L  Q + +  ++           +RS+S  T 
Sbjct: 834  QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 882

Query: 484  NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
               + +    A++ L +  Q      +   +  G   E++   +R+        S   +Q
Sbjct: 883  RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 935

Query: 544  IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
            + ++ +  A++ES+     + +S ++D++ ++  A E+R           T ++++L + 
Sbjct: 936  LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 980

Query: 604  EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
            ++       R+AE Q  +AE+E L   +  L +  E++  L E       +  E     L
Sbjct: 981  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1037

Query: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
             +   +Q+  L     +K++T+          +  L     +LK+ Q             
Sbjct: 1038 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1097

Query: 712  SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
            +  +++  Q    Q   + LR E +    + + +Q+   + ++  ++ +E+   L E++ 
Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1157

Query: 772  QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
             + A+  + + E + L   L+ +   S +    +L   + +      +++I+ + + +++
Sbjct: 1158 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1210

Query: 831  DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
             +++Q  Q   L EEIE+        ++  +     +++    L+  K  LE   +  + 
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1269

Query: 888  EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
              K K+++ +E +  + ++  T   + +++  +   F++ETL   E  E+    L E+  
Sbjct: 1270 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1323

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
              +RE+L   +   +   QL + H +     E E K L+Q  ++  +R RE   +    +
Sbjct: 1324 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1382

Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
              ++Q    Q+    +  +   +R AE +         E S++ +E+++    + +    
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1433

Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
            +Q       L       +LRA   +E  + QK     ++E+   ++Q E+QR   + V  
Sbjct: 1434 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1485

Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
                +       EK +AL +L+E  + A+E + +    E+++  Q+++     Q + +  
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1543

Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
                    +LQ   +       Q   S+  E+   A   E      +   +     E+ E
Sbjct: 1544 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1596

Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
             +  R++++  +     L  +   +   L   +    K   ++    + +  E+ + + E
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1656

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
                 +  Q    E      + +L++ Q+L + + E +  E +  +  L+++L   ++  
Sbjct: 1657 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1711

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
             A     QKR +  +E      +  +  V+  S A+      S  +K+       +G F 
Sbjct: 1712 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1765

Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
             + EE   ++ L  E + Q QL EE A    +   A A++    +++   E T    +A 
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1821

Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
               ++++     ++   +   FQ             + L ++  +H            DI
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1859

Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
             E    +   S+    + K  +   +RQ    E  + ++ AS +     +   ++    +
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919

Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
            R       A + LR     ++E  R+ Q   +EE +R   +   + S+  E   + + + 
Sbjct: 1920 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974

Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
             LEE+E LK      R       + S+ Q Q   E      Q E +   F    KE+EL 
Sbjct: 1975 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034

Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
            +  + E    + L  E    R A ++A    ++   E  ++   VEE         L +S
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2088

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
            ++ Q+ A    ++ AE   K    E   R   E  ++     +D        +++ T  +
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148

Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
              ++ Q L        E D + + L+     RL+A   +     S+   +L   +V   E
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207

Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
            L +   R + +     L+ ++  +  L EE+   +Q+A E ++        A  + L E 
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267

Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
             + ++  + +++ +E + A      L+AE + +Q+++EL   Q   ++ +   + QQL +
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327

Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
            ET+   +        +LE+  +AE+++              +D Q+  K  E ++ E++ 
Sbjct: 2328 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2386

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
            R     QEK T +  L  Q Q  +   E++R+ + E     E E++  QQE + L  QLK
Sbjct: 2387 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2440

Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
                     E QT + EQL     ++T    +  LS++     + +R   IE+ + ++ +
Sbjct: 2441 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2486

Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
            L Q  +  A   ++ + R+     + +  L  S+E   + + +A   + RK++E+  LE+
Sbjct: 2487 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2546

Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
            Q  Q  E L  +N+ +++    LE Q + +    +E+
Sbjct: 2547 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583



 Score =  122 bits (306), Expect = 7e-27
 Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)

Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
            A E    ++ + + QAE + +    K +  L  + E+    L   +     L  +LE+  
Sbjct: 984  ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1037

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
              +  +L+++   + ++ + ++ + L I+ +  A      H    K AQ +     E++ 
Sbjct: 1038 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1095

Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
                + KL+ Q +        +   + +R  +   E L          R+ E+E+  E +
Sbjct: 1096 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1149

Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
             +L +    +  +T +    L +    L++  +   A+ L A  Q      E++  M   
Sbjct: 1150 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1205

Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
            L ++     QL QE   L  ++R  E VE+ Q   +  +N   D+      EL++V  + 
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1259

Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
             L+ + +    K   ++G  S+I    +L T   +L +  S     +++  +++++ +  
Sbjct: 1260 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1318

Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
             +      Q++    +++ E  V AAL  Q QL      AK         +E E   +Q 
Sbjct: 1319 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1363

Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
              Q   +R +E   D       I E   Q+ +   + I  K  Q E AE++ L  E+++ 
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423

Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
             ++  LE  E+++                            G   EL+ALRA +   +A+
Sbjct: 1424 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1456

Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
                +E+AE+L+ ++  +       + +L S+V+     A+EK   L+  +E  +Q  + 
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516

Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
                    ++ ++    Q    L+ +  +   ++  K A   +   Q E S +E    ++
Sbjct: 1517 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1572

Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
            Q  E+ E+  +  A AE    E+    E   LK    + ++L  EE    K++ Q    K
Sbjct: 1573 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1632

Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
            +             A   A + RE+   +                    +EG  ++  +A
Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1679

Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
                 +     LRA   +G Q   L E   +  +  +      +Q  E  L + +A +  
Sbjct: 1680 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1734

Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
            + + K            K + + EAE     +  E  +  R     A +Q  L E     
Sbjct: 1735 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1794

Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
                 E        A+G    L+   +    E +A  E L++     A +R  L E  A 
Sbjct: 1795 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1854

Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
            H A +  R   L++  +SE   Q+ L+E  ++Q++    +++ E+ ++K          S
Sbjct: 1855 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1901

Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
             EK     AEL+ EL + +   E TL++  K   ELEA R                 A E
Sbjct: 1902 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1947

Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
            +++ RE +  ++K  A   +  R  +   EE+E LK  +E  ++   +      +Q QL 
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007

Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
             E+ QK    E +   +  Q  E+     ELQ  L+ E+  + ++    +  R       
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062

Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
             A++Q+     QSR  +   + LK+  ++  +  ++      +L  E E+      Q  Q
Sbjct: 2063 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2122

Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
               + +Q     ++  ++   +  ++  +++ ++  L+ QLEE   Q   LD E QRL+ 
Sbjct: 2123 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2182

Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
               E  +Q  + EE+  S R+  + L++               L+ +IE E +      L
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2222

Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
            I  +   T     L+   +K++ VA +   L   A E  +     +ED +  Q  + E +
Sbjct: 2223 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2279

Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
            L+         E+   V  +T   +  E LL+Q  EL    ++  +E  D   M  +L E
Sbjct: 2280 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2327

Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
            + + +++T           L      +  +++E E        + ++  RAE  A+ ++ 
Sbjct: 2328 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376

Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
            +AE   + L +T     E VTL
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTL 2398



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)

Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
            LL  LEQ  QE+         C      +  +SE++ +  Q+     R +   R    ++
Sbjct: 936  LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 982

Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
            P++E  +   +Q+++Q      E+  +      L  +  +EK++     S  A T + EL
Sbjct: 983  PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1035

Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
            E TL  + + ++ L A  LE K KT  + +     A E  ++ E Q    +         
Sbjct: 1036 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1093

Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
            E  K  L+ L+   E+Q+     L   L   +++    QQ+   +R +   +  E   + 
Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1152

Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
            LE  Q +L    VR RE+      L   RE    L A LQ +    +    +P  D  + 
Sbjct: 1153 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1211

Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
            +++QL ++ + + E+    EK +      +Q +   KD ++   T + + E      KK 
Sbjct: 1212 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1271

Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
             ++QS  E + ++  + R    +L  L  Q ++ I +  ++ E E     + R    + L
Sbjct: 1272 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330

Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
             E    +L   R    + +   + + +    AK ++          E   +  +Q+ + +
Sbjct: 1331 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386

Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
              +LQ L Q +   +Q +     A +   + ++E I  + LQL+    Q+G     +   
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446

Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
             +     E   RQ  E    +  Q+ +E    R   ++L  +++   +  A R+      
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1504

Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
                  ++A  A      +E E   + ++ L+ + + AEAE+   +A     +     S 
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564

Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
              EHV + +     LR E+ R+A
Sbjct: 1565 QEEHVAVAQ-----LREEAERRA 1582



 Score = 35.8 bits (81), Expect = 0.86
 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)

Query: 4    EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
            +E+ ++L+  K ++AQ         QR  +++ Q     S   ++ K R    S+    A
Sbjct: 2308 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2367

Query: 52   HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
              D    + Q  E+      R E     + T+++TL    + + H+     E  +E+   
Sbjct: 2368 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2426

Query: 111  ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
             +    E           K   L  EE   V      Q  Q         +  L  ++  
Sbjct: 2427 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2476

Query: 171  IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
            IE+   +LE++      +  Q  +E +   +Q +    +L A++++ARR + E       
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2536

Query: 231  LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
              E+ Q+L+ Q +Q +               +LL  + Q L  Q QL E+ H
Sbjct: 2537 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2573



 Score = 35.0 bits (79), Expect = 1.5
 Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)

Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
            +QLN+    LQ  +++    KV +   E+ RDL   ++ I  L +D + +K  R  + EQ
Sbjct: 378  EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 437

Query: 2352 LNEVIEKLQQELANI 2366
            +   + +L + L  I
Sbjct: 438  MYRRVYRLHERLVAI 452


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  191 bits (486), Expect = 9e-48
 Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)

Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
            +++  EE   D +Q+   +  + Q+ +Q++E   QA  RQ E     + +++EEI+ +  
Sbjct: 1537 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1596

Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
            QL     QR   + E    +  R   EE EA K+ +    E+L  ++++ S   Q   + 
Sbjct: 1597 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1650

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
            + E+  +   E E  R+ +    + L   R   ++A  RL +  +E  +      ET   
Sbjct: 1651 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1707

Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
                   RS++++  +     +E  A ++  + EEH  V                     
Sbjct: 1708 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1740

Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
            +++ EE    +Q+   +  A  E + E E  +L  N + RL+   E++ +  S   ++ E
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800

Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
              K    E  RE+ R+ +   ++++ +E   + L ++ +  E  A +   AE  +     
Sbjct: 1801 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1857

Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
            E    E+Q Q   + + RL++E   A+ + QELEAE  +++ E E+L             
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917

Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
               + K+ ++AEAG   ++L +E  +L     E + Q +   +D  +Q    E  + E++
Sbjct: 1918 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976

Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
            +   E  + K    + L+++    E + E++R+  +++A  R    +   Q    +E++L
Sbjct: 1977 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032

Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
                        Q R+     + L+ +     + L  + Q++ +I       EK      
Sbjct: 2033 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079

Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
            ELE  L      + DT +  E        +A+ E + + QL AE     R+A +R +K +
Sbjct: 2080 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 2131

Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
               EE   Q +  L    EEV++L  ++E  ++      QE  ++ +L ++  +K   A 
Sbjct: 2132 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187

Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
            +++ A + Q +     +  Q +Q+++  +DQL  +              ++Q + +    
Sbjct: 2188 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244

Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
             + +EE   L +  E Q +     Q   ++ R+E  +   E   + Q E A + QK + +
Sbjct: 2245 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2301

Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
            A     E +  K   +  + +K  +EQ       E+T ++  L+ET+ + N L +EL  L
Sbjct: 2302 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2349

Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
            K E     + +S  E    SV V ++ LSK K  +E       L+  +N   F   EE  
Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2408

Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
            K   +  E   L + +  +A+  +L +     +D+ +Q     +ML++K+  +Q+    K
Sbjct: 2409 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2463

Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
              A L+ Q Q E  QE A+  Q+++   ++      Q   +       R+ E+ ++   L
Sbjct: 2464 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522

Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
             LR++E+                  E    ++H + +  +E+V + +   +++++   + 
Sbjct: 2523 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2582

Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
            ++L E   + +REKEK +  Q+ ++L+  +E   + ++     E +AL+   ++ K  L 
Sbjct: 2583 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640

Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
                     K K E+L ++ + K   +       Q+ + Q R  L  + E+    + E E
Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700

Query: 2756 TEVQESKK 2763
              V+  ++
Sbjct: 2701 EGVRRKQE 2708



 Score =  167 bits (424), Expect = 1e-40
 Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)

Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
            PE       + S L+  + KL +  S ++  LE  K     +     R  Q A E L+  
Sbjct: 1191 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1245

Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
            EE         + +E  AV  +  E      + +K   + + Q+ T   D L  EL  A 
Sbjct: 1246 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1293

Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
               QE+    QQ   ER++   +     A+     Q +L +T+   +E  ++  Q    R
Sbjct: 1294 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1350

Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
            +        L+ D   +  +   +    +  + +  +Q QAL +++E+  + ++E Q   
Sbjct: 1351 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1409

Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
            +++   +   E+Q +  + QL+ V      P+ Q  SE   +E   L  H  E T   S+
Sbjct: 1410 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1469

Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
                       I+  +E + ++E   R  EQ         Q+ E+R+    VEA      
Sbjct: 1470 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1510

Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
               E   + + QAER+A +   R ++E+   EE     +++  +  EE+QQL    E + 
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1570

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
            +    + +  E+     ++++  + L ++ ++      +  L    A+  +E E +  Q 
Sbjct: 1571 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1629

Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
             E+  +L++Q         ++++++  R  E ++   +  +    R ++  ++ L E+  
Sbjct: 1630 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1678

Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
            +LQ                 +EEA+    Q +V  A ++  ALE    +A  E+   +  
Sbjct: 1679 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1721

Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
              E   ++ +      SL+ E  +V +++   E       +   + + E E  L    LK
Sbjct: 1722 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1774

Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
            + E                  L  RL Q E     K L   +  KQ ++ + +    G+ 
Sbjct: 1775 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816

Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
            E + ++++ +  Q++ +++  A   +Q +L A QE  +       + +E E+   Q   Q
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1867

Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
            L E+EL     + +A T +  ELE+++ ++      L+  K + E   ++  EK K+ LE
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1927

Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
                 E    ++  +E  R     E  K   +L    EE       EA R  AE +A   
Sbjct: 1928 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1980

Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
            E    K +AE   +E   +   +  L +D +        Q   H A+ +E+L+ L K  +
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040

Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
            +E++  K          +    E L +K S   A+     L++               I+
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 2089

Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
             N +    S+E  E+ +    ++   +E    E  +   + ++  E   R+   A+    
Sbjct: 2090 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 2145

Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
            EE   LKA ++  R       +E +   +LA   A    Q  E   + +     Q +  T
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205

Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
              Q   +  + RGE +E+A  +          A   E  +V +  E+  S  +    +++
Sbjct: 2206 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2254

Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
             +   E+ +A     ++ + L  + + +  R A+   ++   +  +D   E      +  
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2314

Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
            L +++ +     T    L  TD     N L++ +Q    E   A     + +      R 
Sbjct: 2315 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2372

Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
             + E+  L A++    R + L+ +  +++  QE  E     K  Q+ E    LS     A
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2427

Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
              L         Q++  +EKM+  ++++    T+L+ E  L  Q K L + +A RL+   
Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2487

Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
            +     L  +T       E ++ R+L+ + E E+ KL      R++ R +E+ +  +   
Sbjct: 2488 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2547

Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
            E   ++ L    L  Q+K  L ++ + I+ Q+  +DA+   E    LE +     ++ ++
Sbjct: 2548 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2605

Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
             ++ S   +  +    LQ +    QS   L  +D L + ++ +E++ +++ +L  +    
Sbjct: 2606 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2663

Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
             ++ + +  + +QQME++RQ   + + + +EA     +    ++ K E+LQ+  +++RQQ
Sbjct: 2664 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2720

Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
               L  E QRL+  +Q  ++Q
Sbjct: 2721 EELLAEENQRLREQLQLLEEQ 2741



 Score =  158 bits (399), Expect = 1e-37
 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)

Query: 153  SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
            +PT    +E  L GK  ++  L+   LE+++    V  GT+G ++ L+  E  +K+   +
Sbjct: 1197 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1255

Query: 207  ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
               L       A+L++ R + +     F  L ++   +Q++  + QQ      +      
Sbjct: 1256 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1315

Query: 258  STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
               A LL+  Q +L      Q++LE+    L  Y++  +      ++LQ+  +  E  Q 
Sbjct: 1316 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1372

Query: 314  KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
              + +S   +E++++++ ++EE+        +K  E +         + + + Q+V    
Sbjct: 1373 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1428

Query: 372  EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
            +++ +       K +    S  +E   L     EL     +  +F ++ ++RME+E +R 
Sbjct: 1429 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1487

Query: 430  LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
             EQ RAE                 L E + Q   Q ++E         EE+  R +  ++
Sbjct: 1488 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1547

Query: 473  NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
               +  S   + E+  +L   +  E+  K +   + +    +++EE+ ++   LE     
Sbjct: 1548 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604

Query: 522  ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
                  E  AL+ + E+   +   ++E+ +R R+ + ++  +  +A   L++   +KAE 
Sbjct: 1605 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1662

Query: 576  VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
             +A E ++ L    EL+ +AE    +++   +E+ +     L+    S EAEL+  R   
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1720

Query: 630  LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
              S  E+ ++L+  L+ EH + + +L++      +QQ +    + E  +++E  Q + + 
Sbjct: 1721 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1777

Query: 688  LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
             +  + Q   E+++ K L Q+              E +K+ E   +E + +G   EQ V+
Sbjct: 1778 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1822

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            + +L  + LEKQ +  E   Q++ A   AE  +++         L+  T   +++R +  
Sbjct: 1823 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1870

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
            + +      +  ++E     ++ ++L+ +  ++  E+           E+ R+T   +++
Sbjct: 1871 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1924

Query: 856  NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
              E     ++EL EE A L  + ++        E+   +Q  E +     KL A+ E   
Sbjct: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1984

Query: 902  LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
            L+      +K K +  +      ED+ F    LE  E   +   ++ E+L ++ K    E
Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 2042

Query: 955  LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
            L ++   + + L+Q+      + EE+ +LK   E+ +    ELE+ +   R+    +  +
Sbjct: 2043 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098

Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
            +  + L+      +     R    +  +V KS   E +   + K + E +   +   +E 
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158

Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
              L           L+  Q +   +LQ E   +    +Q +  LQ   Q+        + 
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2212

Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
            +DQ+R   E  + +A    +E  + A+ E  +  +++ + E      +E           
Sbjct: 2213 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2271

Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
              KL+K   +E +   Q   + L +      + E + +  E              Q  R 
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2317

Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
            + Q  QE + TL  ++ E  ++  +L   L ++  + T+  +         + E E  S+
Sbjct: 2318 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2370

Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
              QM  L  +   +  +++   L+D + T+  L+E+ ++++ +      +S   Q+    
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430

Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
             Q  E ++          L++++QAV E+T       L      + +  A+R       +
Sbjct: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490

Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
             + +            +E     + LE + Q QLE       + + +A     E+SR   
Sbjct: 2491 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2534

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
              E  A   +  A    E+ +  E+   +     QT E    +   + + L + + E  +
Sbjct: 2535 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2594

Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
            E      +   +    + + T+ +E   ++ T  ++QS   E   S +   R +   + +
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2652

Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
            LE +        Q+L  + Q  QQ  E  RQ  +  ME  R  Q + +E ++R   +L Q
Sbjct: 2653 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2712

Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
              +     E L++E  + L E+L+ L++    +LA  E++      ++    NG +
Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2768



 Score =  149 bits (376), Expect = 5e-35
 Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)

Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
            A E++  +R I E  DI  +LE    C +  +  L     + +  RE   R  E  KA+A
Sbjct: 1113 AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1168

Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
                 G    +L  E EK++    E    A  +R +L+  +  LE     QV     +  
Sbjct: 1169 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1222

Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
            EK   +  + +  Q  E+ L    + L E QA+     E +  +  ++KL  Q +   P 
Sbjct: 1223 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1282

Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
            F  + + + R  +++   L+++  ++  E+   +E++ + ++     + + + R RELEQ
Sbjct: 1283 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341

Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
             L      +++  D       +A+     + Q+QA   A  +  +E    E+ L    EE
Sbjct: 1342 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1394

Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
            +E   E+V++         K+    +++ E +   +K  +E +    K+    S  +   
Sbjct: 1395 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1448

Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
                   +IQE        +E  T   Q +K  +         E +R +E + E L   Q
Sbjct: 1449 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1491

Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
               +R R  E+E     +EK Q++LA    +    A   ++E    + Q +VV  E+ A+
Sbjct: 1492 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1546

Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
            + Q +         K  ++E   ++ Q ++ E+ +  R+ E+ E+               
Sbjct: 1547 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1582

Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
             S+ + E E+ +    L++ E Q          +G +  L  R  + E+       E  +
Sbjct: 1583 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1635

Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
              +Q++D  Q + Q E E+  +     +   E++ A   + +++L+A +E  +  +  + 
Sbjct: 1636 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1694

Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
              +   +  ++   +  E EL S  ++   + ++LE  + E H ++   +E+ E   +  
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1754

Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
             E E+   E ++ LE  + K  E            +++S    E  K   E        G
Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1814

Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
               E +A+R   +A + EL   ++ AE   ++ L  E  +  L+ +  Q        +E+
Sbjct: 1815 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1872

Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
            L+ L++E     Q     E++ A +   + + L+    ++ +     S+S ++ Q L   
Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1929

Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
            AG    L  E +      E  +   Q  E+    Q   A  +L  +   I E   LK E 
Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1989

Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
             +A   LKE            +  E   +  LA  +A+Q R +                 
Sbjct: 1990 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034

Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
               +SDS  +  +G+               L     F+ A+ G+ E          +A D
Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094

Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
            +   K +  L A      Q+ +  E    + E+   + ++  E    +RKA +  +  LK
Sbjct: 2095 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2152

Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
              + + +  RE    +S++  +   +   + L A               LQQ   +E+SV
Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2212

Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
            L                   A  + E  A  +   V     L+Q  +EQ     + QAA 
Sbjct: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272

Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
            E L+K   +      QA  A +  ++      ++ +K +++ L    Q +Q ++  ++++
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2331

Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
            L     +   L E+L   K    E   + +Q + EL  +++ Q + L +L+A R+E +++
Sbjct: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2389

Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
               +   ++T    Q+++ +++   E+         E A+L +  E D  +   L   + 
Sbjct: 2390 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2449

Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
             +K + +Q          LL+QQK+L  E  ++++  +     QL+EE QG         
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2509

Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
             R LE+    E  K+R+ EMS    R E +     + ++  G+   R  L +++ +    
Sbjct: 2510 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2569

Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
              E+Q+Q      E     I EL  E EK          K + +QT QQ +  ++ Q  +
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2629

Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
            ++  +E+++  + ++ + + ++K+E L        Q+  EE+++Q  +++ E QRL   M
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2689

Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
            +E ++++ E EE    ++   Q L +
Sbjct: 2690 EEARRRQHEAEEGVRRKQEELQQLEQ 2715



 Score =  146 bits (369), Expect = 3e-34
 Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)

Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
            L+       Q++   +  ++ +RE  RQ+Q   E ++        CQ   ++ ++     
Sbjct: 1360 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419

Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
              QL    ++                +E VI  Y D +T       L  + I+  ++ + 
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1479

Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
            R+E+E   A         RL E+EA  ++ ++  E  ++ K   + EA  ++Q++ +E  
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539

Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
            +  +  ++ Q Q   ++++LQ+  ++ E +++ +  +    E+ +     E+  +R Q +
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599

Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
            A E+Q    E   + L  +A + E ++   Q+E ++L +Q+      Q  S+ + +   +
Sbjct: 1600 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1653

Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
            LA+ +K + +   E    K++  + ++E   + E+ E R+R+ E    + + V+ +T Q+
Sbjct: 1654 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709

Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
              +      R  F    A+ E SL+       QL+ E +   +++ E     E+ E+  E
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769

Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
              + K  E  +L +Q E   ++ +    E E++ +  + +  + G A             
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1816

Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
                      +E+ V   +L EQ  + Q+QL   T  + +  + ELIR        L ++
Sbjct: 1817 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1858

Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
             E      E++ + L E + +LQ+E A   QK       L  E   ++ +++V++A K  
Sbjct: 1859 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1910

Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
             E++  + +E+    K  L+    +  +L +E   L+   E  ++ + + E         
Sbjct: 1911 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967

Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
                      AI   ++ K E E+ L E     + L+ L     F  +  EE       +
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027

Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
            +E RL QL     A D EL +    ++D   Q +     ++++I+ L+   E+  A    
Sbjct: 2028 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 2080

Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
             +++L  ++  A+      T+ S+ +      L   R+ +L ++      R  E E +V 
Sbjct: 2081 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 2128

Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
            +   SL  E+E      K  LE+ ++L    K      ++ RE+ ++ S + +++ +   
Sbjct: 2129 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2180

Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
            +              + L+AE    KA   + ++K ++LQ+ L  +++ +  L+ +    
Sbjct: 2181 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2223

Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
            R    EA+E     E+E      +V+E+++         +      +  +   K +    
Sbjct: 2224 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283

Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
              +   + A ++    ++   E+  +   Q   +K +  QEL    +       + ET+ 
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2337

Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
             K        LL EE   LKA      +++ S + E   S   Q  E+    +       
Sbjct: 2338 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2383

Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
                      I +E R      +  T  F ++    ++ V  E  ++    +      E 
Sbjct: 2384 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2427

Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
              ++Q++E  L +++A        K L  KMQ  +EA    +              LL  
Sbjct: 2428 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2471

Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
            Q+   +E++  L   + ++      +  G    LE   Q Q +E  A  E L+   R + 
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2528

Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
            +S  QA  A+ + ++   + E+  EK  +   E   Q+K + +  ++++       A  L
Sbjct: 2529 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2585

Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
            +E        +AEL+ E  + KL+ E  L      LK  E   ++ +    E   L  + 
Sbjct: 2586 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2632

Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
             SE+    + +  +E+EKAKL +  + +  + + L+   + Q+Q+       +EQ++Q L
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2685

Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
              S +  E++R  ++A+      +E+ + LE Q      LL  E  R+RE    L+ +  
Sbjct: 2686 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743

Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
                H++  ++     ++      D L     + E +HS
Sbjct: 2744 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2782



 Score =  142 bits (359), Expect = 5e-33
 Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)

Query: 417  DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
            DI  ++E    R + +LR  LD+   ++  Q    +  Q  AQ          E+E   +
Sbjct: 1128 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1175

Query: 477  SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
              + ++   +++  +   + A   L  +L+ T  + E+++    + LE+   +    R  
Sbjct: 1176 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1235

Query: 531  EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
            +   E L    EQ++ A+    T+ E E+      KL  +A     T + L+ E+  A E
Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1295

Query: 581  SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
              + L+ +H   + EV  ++ ++  L +   AVL +  + ++ ELE+L  QL +  E   
Sbjct: 1296 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1354

Query: 638  ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
               + L++    + +I    L D+  +  + +Q   L  E+    +K+E  Q F K  + 
Sbjct: 1355 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1414

Query: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
              ++  +  ++    L+     +K  ++      + +E   LR    E  TL  +    +
Sbjct: 1415 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1474

Query: 746  QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
             E   + E  E+  +++  + +E+ A++EA    L+ +++  E   +      +E +   
Sbjct: 1475 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1528

Query: 806  LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
               ++ + ++ V  +E     E   D +QQ   + EE+++ R +   +E   +   ++ +
Sbjct: 1529 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1578

Query: 866  EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
                  L++++++   + + E   + +  A  E   LQ +     + +           A
Sbjct: 1579 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1624

Query: 926  ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
            +  +  E  E+   ++ ++ +  ++ ++EL+ R+   +E  ++K   +  L E    L+ 
Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1680

Query: 986  EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
            + E+   R R+ E+     RA  VQ             +    R AE  +     SF E+
Sbjct: 1681 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1725

Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
            +  +             E S QE+ +   +  + +E+  RA Q +E ++ ++E     +E
Sbjct: 1726 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1765

Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
            +   R Q++A       + +  V Q +   + E +K            +EE  +E ++  
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1814

Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
            + E Q ++ +E  ++   K   L  G  Q+ ++ E                   L+ E  
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1860

Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
              +++     + E E   LQ         ++ +   L KV  E   LL      SK   +
Sbjct: 1861 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1912

Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
            +      E  ++ L  E   F  +  +   L  +    K +    + L +     Q  E 
Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1968

Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
            E +++     + E T    EAEI   +K     RL+ ++E        ++      ++D 
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028

Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
            +  +   + ++K  D  +E   + G+ E+T        + + Q+EEE+  +  S   A A
Sbjct: 2029 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 2076

Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
             + EL     RI    E+T  SK         Q     ++E+                E 
Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136

Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
               Q +   +  E +  K +E  +   +   E  +++ L+          E K     + 
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2196

Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
            ++     +T    QS+ D++   +  A R        ++    E  +  RQ    E ++Q
Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256

Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
              E Q       QA   ++ ++ E +   + Q E   L ++ A  + ++     +E   R
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316

Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
            ++  +E EL  L+ QL     +K  L  EL+    +       + +VEE+ F  +    +
Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376

Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
               +   I +  R  + +  +   + L E  +    V E   R        S  +Q +A 
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2429

Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
            L   +E + + +  + E+  +   +++   +        +   +++ ++  EL+Q   R 
Sbjct: 2430 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2481

Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
                  +  + E++   ++   Q   ++ LEA      E S++ E  K+   E+ R   R
Sbjct: 2482 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2535

Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
             +++A    K  EE+ E+LH    A ++    +                 E Q Q+    
Sbjct: 2536 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2581

Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
             +RL + +        ELE E++++Q+E +LL  + E M+      ++QLLQET+ L + 
Sbjct: 2582 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2631

Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
             L         +D L ++    E  +E++ ++  +L Q++  +   LR++ Q  ++Q+E+
Sbjct: 2632 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680

Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
             R+ L    E+A  R+HE +   +  Q+  QQL          E Q R+ E+L   L E+
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2727

Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
              +  E L   E+  R     +EE+   +          + +  T     D     A EA
Sbjct: 2728 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2777

Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
            +PE S +  L+ +  A   +E  I + EE
Sbjct: 2778 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2805



 Score =  140 bits (353), Expect = 2e-32
 Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)

Query: 424  QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
            QE   +LE     L  ++ Q  V MK  L  Q + +  ++           +RS+S  T 
Sbjct: 1003 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 1051

Query: 484  NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
               + +    A++ L +  Q      +   +  G   E++   +R+        S   +Q
Sbjct: 1052 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 1104

Query: 544  IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
            + ++ +  A++ES+     + +S ++D++ ++  A E+R           T ++++L + 
Sbjct: 1105 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1149

Query: 604  EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
            ++       R+AE Q  +AE+E L   +  L +  E++  L E       +  E     L
Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1206

Query: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
             +   +Q+  L     +K++T+          +  L     +LK+ Q             
Sbjct: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1266

Query: 712  SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
            +  +++  Q    Q   + LR E +    + + +Q+   + ++  ++ +E+   L E++ 
Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1326

Query: 772  QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
             + A+  + + E + L   L+ +   S +    +L   + +      +++I+ + + +++
Sbjct: 1327 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1379

Query: 831  DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
             +++Q  Q   L EEIE+        ++  +     +++    L+  K  LE   +  + 
Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1438

Query: 888  EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
              K K+++ +E +  + ++  T   + +++  +   F++ETL   E  E+    L E+  
Sbjct: 1439 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1492

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
              +RE+L   +   +   QL + H +     E E K L+Q  ++  +R RE   +    +
Sbjct: 1493 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1551

Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
              ++Q    Q+    +  +   +R AE +         E S++ +E+++    + +    
Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1602

Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
            +Q       L       +LRA   +E  + QK     ++E+   ++Q E+QR   + V  
Sbjct: 1603 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654

Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
                +       EK +AL +L+E  + A+E + +    E+++  Q+++     Q + +  
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1712

Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
                    +LQ   +       Q   S+  E+   A   E      +   +     E+ E
Sbjct: 1713 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1765

Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
             +  R++++  +     L  +   +   L   +    K   ++    + +  E+ + + E
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1825

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
                 +  Q    E      + +L++ Q+L + + E +  E +  +  L+++L   ++  
Sbjct: 1826 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1880

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
             A     QKR +  +E      +  +  V+  S A+      S  +K+       +G F 
Sbjct: 1881 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1934

Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
             + EE   ++ L  E + Q QL EE A    +   A A++    +++   E T    +A 
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1990

Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
               ++++     ++   +   FQ             + L ++  +H            DI
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 2028

Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
             E    +   S+    + K  +   +RQ    E  + ++ AS +     +   ++    +
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088

Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
            R       A + LR     ++E  R+ Q   +EE +R   +   + S+  E   + + + 
Sbjct: 2089 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143

Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
             LEE+E LK      R       + S+ Q Q   E      Q E +   F    KE+EL 
Sbjct: 2144 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203

Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
            +  + E    + L  E    R A ++A    ++   E  ++   VEE         L +S
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2257

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
            ++ Q+ A    ++ AE   K    E   R   E  ++     +D        +++ T  +
Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317

Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
              ++ Q L        E D + + L+     RL+A   +     S+   +L   +V   E
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376

Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
            L +   R + +     L+ ++  +  L EE+   +Q+A E ++        A  + L E 
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436

Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
             + ++  + +++ +E + A      L+AE + +Q+++EL   Q   ++ +   + QQL +
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496

Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
            ET+   +        +LE+  +AE+++              +D Q+  K  E ++ E++ 
Sbjct: 2497 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2555

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
            R     QEK T +  L  Q Q  +   E++R+ + E     E E++  QQE + L  QLK
Sbjct: 2556 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2609

Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
                     E QT + EQL     ++T    +  LS++     + +R   IE+ + ++ +
Sbjct: 2610 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2655

Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
            L Q  +  A   ++ + R+     + +  L  S+E   + + +A   + RK++E+  LE+
Sbjct: 2656 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2715

Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
            Q  Q  E L  +N+ +++    LE Q + +    +E+
Sbjct: 2716 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752



 Score =  122 bits (306), Expect = 7e-27
 Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)

Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
            A E    ++ + + QAE + +    K +  L  + E+    L   +     L  +LE+  
Sbjct: 1153 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1206

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
              +  +L+++   + ++ + ++ + L I+ +  A      H    K AQ +     E++ 
Sbjct: 1207 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1264

Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
                + KL+ Q +        +   + +R  +   E L          R+ E+E+  E +
Sbjct: 1265 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1318

Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
             +L +    +  +T +    L +    L++  +   A+ L A  Q      E++  M   
Sbjct: 1319 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1374

Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
            L ++     QL QE   L  ++R  E VE+ Q   +  +N   D+      EL++V  + 
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1428

Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
             L+ + +    K   ++G  S+I    +L T   +L +  S     +++  +++++ +  
Sbjct: 1429 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1487

Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
             +      Q++    +++ E  V AAL  Q QL      AK         +E E   +Q 
Sbjct: 1488 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1532

Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
              Q   +R +E   D       I E   Q+ +   + I  K  Q E AE++ L  E+++ 
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592

Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
             ++  LE  E+++                            G   EL+ALRA +   +A+
Sbjct: 1593 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1625

Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
                +E+AE+L+ ++  +       + +L S+V+     A+EK   L+  +E  +Q  + 
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685

Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
                    ++ ++    Q    L+ +  +   ++  K A   +   Q E S +E    ++
Sbjct: 1686 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1741

Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
            Q  E+ E+  +  A AE    E+    E   LK    + ++L  EE    K++ Q    K
Sbjct: 1742 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1801

Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
            +             A   A + RE+   +                    +EG  ++  +A
Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1848

Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
                 +     LRA   +G Q   L E   +  +  +      +Q  E  L + +A +  
Sbjct: 1849 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1903

Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
            + + K            K + + EAE     +  E  +  R     A +Q  L E     
Sbjct: 1904 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1963

Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
                 E        A+G    L+   +    E +A  E L++     A +R  L E  A 
Sbjct: 1964 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 2023

Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
            H A +  R   L++  +SE   Q+ L+E  ++Q++    +++ E+ ++K          S
Sbjct: 2024 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 2070

Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
             EK     AEL+ EL + +   E TL++  K   ELEA R                 A E
Sbjct: 2071 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 2116

Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
            +++ RE +  ++K  A   +  R  +   EE+E LK  +E  ++   +      +Q QL 
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176

Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
             E+ QK    E +   +  Q  E+     ELQ  L+ E+  + ++    +  R       
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231

Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
             A++Q+     QSR  +   + LK+  ++  +  ++      +L  E E+      Q  Q
Sbjct: 2232 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2291

Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
               + +Q     ++  ++   +  ++  +++ ++  L+ QLEE   Q   LD E QRL+ 
Sbjct: 2292 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2351

Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
               E  +Q  + EE+  S R+  + L++               L+ +IE E +      L
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2391

Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
            I  +   T     L+   +K++ VA +   L   A E  +     +ED +  Q  + E +
Sbjct: 2392 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2448

Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
            L+         E+   V  +T   +  E LL+Q  EL    ++  +E  D   M  +L E
Sbjct: 2449 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2496

Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
            + + +++T           L      +  +++E E        + ++  RAE  A+ ++ 
Sbjct: 2497 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545

Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
            +AE   + L +T     E VTL
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTL 2567



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)

Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
            LL  LEQ  QE+         C      +  +SE++ +  Q+     R +   R    ++
Sbjct: 1105 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1151

Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
            P++E  +   +Q+++Q      E+  +      L  +  +EK++     S  A T + EL
Sbjct: 1152 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1204

Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
            E TL  + + ++ L A  LE K KT  + +     A E  ++ E Q    +         
Sbjct: 1205 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1262

Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
            E  K  L+ L+   E+Q+     L   L   +++    QQ+   +R +   +  E   + 
Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1321

Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
            LE  Q +L    VR RE+      L   RE    L A LQ +    +    +P  D  + 
Sbjct: 1322 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1380

Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
            +++QL ++ + + E+    EK +      +Q +   KD ++   T + + E      KK 
Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440

Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
             ++QS  E + ++  + R    +L  L  Q ++ I +  ++ E E     + R    + L
Sbjct: 1441 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499

Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
             E    +L   R    + +   + + +    AK ++          E   +  +Q+ + +
Sbjct: 1500 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555

Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
              +LQ L Q +   +Q +     A +   + ++E I  + LQL+    Q+G     +   
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615

Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
             +     E   RQ  E    +  Q+ +E    R   ++L  +++   +  A R+      
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1673

Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
                  ++A  A      +E E   + ++ L+ + + AEAE+   +A     +     S 
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733

Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
              EHV + +     LR E+ R+A
Sbjct: 1734 QEEHVAVAQ-----LREEAERRA 1751



 Score = 35.8 bits (81), Expect = 0.86
 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)

Query: 4    EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
            +E+ ++L+  K ++AQ         QR  +++ Q     S   ++ K R    S+    A
Sbjct: 2477 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2536

Query: 52   HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
              D    + Q  E+      R E     + T+++TL    + + H+     E  +E+   
Sbjct: 2537 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2595

Query: 111  ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
             +    E           K   L  EE   V      Q  Q         +  L  ++  
Sbjct: 2596 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2645

Query: 171  IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
            IE+   +LE++      +  Q  +E +   +Q +    +L A++++ARR + E       
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2705

Query: 231  LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
              E+ Q+L+ Q +Q +               +LL  + Q L  Q QL E+ H
Sbjct: 2706 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2742



 Score = 35.0 bits (79), Expect = 1.5
 Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)

Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
            +QLN+    LQ  +++    KV +   E+ RDL   ++ I  L +D + +K  R  + EQ
Sbjct: 547  EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 606

Query: 2352 LNEVIEKLQQELANI 2366
            +   + +L + L  I
Sbjct: 607  MYRRVYRLHERLVAI 621


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  191 bits (486), Expect = 9e-48
 Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)

Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
            +++  EE   D +Q+   +  + Q+ +Q++E   QA  RQ E     + +++EEI+ +  
Sbjct: 1378 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1437

Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
            QL     QR   + E    +  R   EE EA K+ +    E+L  ++++ S   Q   + 
Sbjct: 1438 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1491

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
            + E+  +   E E  R+ +    + L   R   ++A  RL +  +E  +      ET   
Sbjct: 1492 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1548

Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
                   RS++++  +     +E  A ++  + EEH  V                     
Sbjct: 1549 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1581

Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
            +++ EE    +Q+   +  A  E + E E  +L  N + RL+   E++ +  S   ++ E
Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641

Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
              K    E  RE+ R+ +   ++++ +E   + L ++ +  E  A +   AE  +     
Sbjct: 1642 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1698

Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
            E    E+Q Q   + + RL++E   A+ + QELEAE  +++ E E+L             
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758

Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
               + K+ ++AEAG   ++L +E  +L     E + Q +   +D  +Q    E  + E++
Sbjct: 1759 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817

Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
            +   E  + K    + L+++    E + E++R+  +++A  R    +   Q    +E++L
Sbjct: 1818 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873

Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
                        Q R+     + L+ +     + L  + Q++ +I       EK      
Sbjct: 1874 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920

Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
            ELE  L      + DT +  E        +A+ E + + QL AE     R+A +R +K +
Sbjct: 1921 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1972

Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
               EE   Q +  L    EEV++L  ++E  ++      QE  ++ +L ++  +K   A 
Sbjct: 1973 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028

Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
            +++ A + Q +     +  Q +Q+++  +DQL  +              ++Q + +    
Sbjct: 2029 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085

Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
             + +EE   L +  E Q +     Q   ++ R+E  +   E   + Q E A + QK + +
Sbjct: 2086 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2142

Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
            A     E +  K   +  + +K  +EQ       E+T ++  L+ET+ + N L +EL  L
Sbjct: 2143 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2190

Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
            K E     + +S  E    SV V ++ LSK K  +E       L+  +N   F   EE  
Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2249

Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
            K   +  E   L + +  +A+  +L +     +D+ +Q     +ML++K+  +Q+    K
Sbjct: 2250 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2304

Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
              A L+ Q Q E  QE A+  Q+++   ++      Q   +       R+ E+ ++   L
Sbjct: 2305 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363

Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
             LR++E+                  E    ++H + +  +E+V + +   +++++   + 
Sbjct: 2364 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2423

Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
            ++L E   + +REKEK +  Q+ ++L+  +E   + ++     E +AL+   ++ K  L 
Sbjct: 2424 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2481

Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
                     K K E+L ++ + K   +       Q+ + Q R  L  + E+    + E E
Sbjct: 2482 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541

Query: 2756 TEVQESKK 2763
              V+  ++
Sbjct: 2542 EGVRRKQE 2549



 Score =  167 bits (424), Expect = 1e-40
 Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)

Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
            PE       + S L+  + KL +  S ++  LE  K     +     R  Q A E L+  
Sbjct: 1032 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1086

Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
            EE         + +E  AV  +  E      + +K   + + Q+ T   D L  EL  A 
Sbjct: 1087 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1134

Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
               QE+    QQ   ER++   +     A+     Q +L +T+   +E  ++  Q    R
Sbjct: 1135 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1191

Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
            +        L+ D   +  +   +    +  + +  +Q QAL +++E+  + ++E Q   
Sbjct: 1192 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1250

Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
            +++   +   E+Q +  + QL+ V      P+ Q  SE   +E   L  H  E T   S+
Sbjct: 1251 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1310

Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
                       I+  +E + ++E   R  EQ         Q+ E+R+    VEA      
Sbjct: 1311 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1351

Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
               E   + + QAER+A +   R ++E+   EE     +++  +  EE+QQL    E + 
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1411

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
            +    + +  E+     ++++  + L ++ ++      +  L    A+  +E E +  Q 
Sbjct: 1412 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1470

Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
             E+  +L++Q         ++++++  R  E ++   +  +    R ++  ++ L E+  
Sbjct: 1471 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1519

Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
            +LQ                 +EEA+    Q +V  A ++  ALE    +A  E+   +  
Sbjct: 1520 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1562

Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
              E   ++ +      SL+ E  +V +++   E       +   + + E E  L    LK
Sbjct: 1563 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1615

Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
            + E                  L  RL Q E     K L   +  KQ ++ + +    G+ 
Sbjct: 1616 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1657

Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
            E + ++++ +  Q++ +++  A   +Q +L A QE  +       + +E E+   Q   Q
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1708

Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
            L E+EL     + +A T +  ELE+++ ++      L+  K + E   ++  EK K+ LE
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1768

Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
                 E    ++  +E  R     E  K   +L    EE       EA R  AE +A   
Sbjct: 1769 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1821

Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
            E    K +AE   +E   +   +  L +D +        Q   H A+ +E+L+ L K  +
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881

Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
            +E++  K          +    E L +K S   A+     L++               I+
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1930

Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
             N +    S+E  E+ +    ++   +E    E  +   + ++  E   R+   A+    
Sbjct: 1931 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 1986

Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
            EE   LKA ++  R       +E +   +LA   A    Q  E   + +     Q +  T
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046

Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
              Q   +  + RGE +E+A  +          A   E  +V +  E+  S  +    +++
Sbjct: 2047 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2095

Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
             +   E+ +A     ++ + L  + + +  R A+   ++   +  +D   E      +  
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2155

Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
            L +++ +     T    L  TD     N L++ +Q    E   A     + +      R 
Sbjct: 2156 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2213

Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
             + E+  L A++    R + L+ +  +++  QE  E     K  Q+ E    LS     A
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2268

Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
              L         Q++  +EKM+  ++++    T+L+ E  L  Q K L + +A RL+   
Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2328

Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
            +     L  +T       E ++ R+L+ + E E+ KL      R++ R +E+ +  +   
Sbjct: 2329 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2388

Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
            E   ++ L    L  Q+K  L ++ + I+ Q+  +DA+   E    LE +     ++ ++
Sbjct: 2389 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2446

Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
             ++ S   +  +    LQ +    QS   L  +D L + ++ +E++ +++ +L  +    
Sbjct: 2447 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2504

Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
             ++ + +  + +QQME++RQ   + + + +EA     +    ++ K E+LQ+  +++RQQ
Sbjct: 2505 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2561

Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
               L  E QRL+  +Q  ++Q
Sbjct: 2562 EELLAEENQRLREQLQLLEEQ 2582



 Score =  158 bits (399), Expect = 1e-37
 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)

Query: 153  SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
            +PT    +E  L GK  ++  L+   LE+++    V  GT+G ++ L+  E  +K+   +
Sbjct: 1038 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1096

Query: 207  ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
               L       A+L++ R + +     F  L ++   +Q++  + QQ      +      
Sbjct: 1097 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1156

Query: 258  STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
               A LL+  Q +L      Q++LE+    L  Y++  +      ++LQ+  +  E  Q 
Sbjct: 1157 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1213

Query: 314  KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
              + +S   +E++++++ ++EE+        +K  E +         + + + Q+V    
Sbjct: 1214 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1269

Query: 372  EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
            +++ +       K +    S  +E   L     EL     +  +F ++ ++RME+E +R 
Sbjct: 1270 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1328

Query: 430  LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
             EQ RAE                 L E + Q   Q ++E         EE+  R +  ++
Sbjct: 1329 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1388

Query: 473  NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
               +  S   + E+  +L   +  E+  K +   + +    +++EE+ ++   LE     
Sbjct: 1389 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1445

Query: 522  ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
                  E  AL+ + E+   +   ++E+ +R R+ + ++  +  +A   L++   +KAE 
Sbjct: 1446 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1503

Query: 576  VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
             +A E ++ L    EL+ +AE    +++   +E+ +     L+    S EAEL+  R   
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1561

Query: 630  LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
              S  E+ ++L+  L+ EH + + +L++      +QQ +    + E  +++E  Q + + 
Sbjct: 1562 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1618

Query: 688  LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
             +  + Q   E+++ K L Q+              E +K+ E   +E + +G   EQ V+
Sbjct: 1619 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1663

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            + +L  + LEKQ +  E   Q++ A   AE  +++         L+  T   +++R +  
Sbjct: 1664 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1711

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
            + +      +  ++E     ++ ++L+ +  ++  E+           E+ R+T   +++
Sbjct: 1712 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1765

Query: 856  NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
              E     ++EL EE A L  + ++        E+   +Q  E +     KL A+ E   
Sbjct: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1825

Query: 902  LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
            L+      +K K +  +      ED+ F    LE  E   +   ++ E+L ++ K    E
Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1883

Query: 955  LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
            L ++   + + L+Q+      + EE+ +LK   E+ +    ELE+ +   R+    +  +
Sbjct: 1884 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939

Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
            +  + L+      +     R    +  +V KS   E +   + K + E +   +   +E 
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999

Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
              L           L+  Q +   +LQ E   +    +Q +  LQ   Q+        + 
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2053

Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
            +DQ+R   E  + +A    +E  + A+ E  +  +++ + E      +E           
Sbjct: 2054 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2112

Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
              KL+K   +E +   Q   + L +      + E + +  E              Q  R 
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2158

Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
            + Q  QE + TL  ++ E  ++  +L   L ++  + T+  +         + E E  S+
Sbjct: 2159 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2211

Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
              QM  L  +   +  +++   L+D + T+  L+E+ ++++ +      +S   Q+    
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271

Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
             Q  E ++          L++++QAV E+T       L      + +  A+R       +
Sbjct: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331

Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
             + +            +E     + LE + Q QLE       + + +A     E+SR   
Sbjct: 2332 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2375

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
              E  A   +  A    E+ +  E+   +     QT E    +   + + L + + E  +
Sbjct: 2376 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2435

Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
            E      +   +    + + T+ +E   ++ T  ++QS   E   S +   R +   + +
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2493

Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
            LE +        Q+L  + Q  QQ  E  RQ  +  ME  R  Q + +E ++R   +L Q
Sbjct: 2494 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2553

Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
              +     E L++E  + L E+L+ L++    +LA  E++      ++    NG +
Sbjct: 2554 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2609



 Score =  149 bits (376), Expect = 5e-35
 Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)

Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
            A E++  +R I E  DI  +LE    C +  +  L     + +  RE   R  E  KA+A
Sbjct: 954  AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1009

Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
                 G    +L  E EK++    E    A  +R +L+  +  LE     QV     +  
Sbjct: 1010 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1063

Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
            EK   +  + +  Q  E+ L    + L E QA+     E +  +  ++KL  Q +   P 
Sbjct: 1064 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1123

Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
            F  + + + R  +++   L+++  ++  E+   +E++ + ++     + + + R RELEQ
Sbjct: 1124 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182

Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
             L      +++  D       +A+     + Q+QA   A  +  +E    E+ L    EE
Sbjct: 1183 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1235

Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
            +E   E+V++         K+    +++ E +   +K  +E +    K+    S  +   
Sbjct: 1236 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1289

Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
                   +IQE        +E  T   Q +K  +         E +R +E + E L   Q
Sbjct: 1290 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1332

Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
               +R R  E+E     +EK Q++LA    +    A   ++E    + Q +VV  E+ A+
Sbjct: 1333 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1387

Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
            + Q +         K  ++E   ++ Q ++ E+ +  R+ E+ E+               
Sbjct: 1388 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1423

Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
             S+ + E E+ +    L++ E Q          +G +  L  R  + E+       E  +
Sbjct: 1424 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1476

Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
              +Q++D  Q + Q E E+  +     +   E++ A   + +++L+A +E  +  +  + 
Sbjct: 1477 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1535

Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
              +   +  ++   +  E EL S  ++   + ++LE  + E H ++   +E+ E   +  
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1595

Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
             E E+   E ++ LE  + K  E            +++S    E  K   E        G
Sbjct: 1596 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1655

Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
               E +A+R   +A + EL   ++ AE   ++ L  E  +  L+ +  Q        +E+
Sbjct: 1656 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1713

Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
            L+ L++E     Q     E++ A +   + + L+    ++ +     S+S ++ Q L   
Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1770

Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
            AG    L  E +      E  +   Q  E+    Q   A  +L  +   I E   LK E 
Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1830

Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
             +A   LKE            +  E   +  LA  +A+Q R +                 
Sbjct: 1831 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875

Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
               +SDS  +  +G+               L     F+ A+ G+ E          +A D
Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935

Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
            +   K +  L A      Q+ +  E    + E+   + ++  E    +RKA +  +  LK
Sbjct: 1936 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1993

Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
              + + +  RE    +S++  +   +   + L A               LQQ   +E+SV
Sbjct: 1994 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2053

Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
            L                   A  + E  A  +   V     L+Q  +EQ     + QAA 
Sbjct: 2054 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2113

Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
            E L+K   +      QA  A +  ++      ++ +K +++ L    Q +Q ++  ++++
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2172

Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
            L     +   L E+L   K    E   + +Q + EL  +++ Q + L +L+A R+E +++
Sbjct: 2173 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2230

Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
               +   ++T    Q+++ +++   E+         E A+L +  E D  +   L   + 
Sbjct: 2231 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2290

Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
             +K + +Q          LL+QQK+L  E  ++++  +     QL+EE QG         
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2350

Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
             R LE+    E  K+R+ EMS    R E +     + ++  G+   R  L +++ +    
Sbjct: 2351 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2410

Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
              E+Q+Q      E     I EL  E EK          K + +QT QQ +  ++ Q  +
Sbjct: 2411 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2470

Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
            ++  +E+++  + ++ + + ++K+E L        Q+  EE+++Q  +++ E QRL   M
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2530

Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
            +E ++++ E EE    ++   Q L +
Sbjct: 2531 EEARRRQHEAEEGVRRKQEELQQLEQ 2556



 Score =  146 bits (369), Expect = 3e-34
 Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)

Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
            L+       Q++   +  ++ +RE  RQ+Q   E ++        CQ   ++ ++     
Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260

Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
              QL    ++                +E VI  Y D +T       L  + I+  ++ + 
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320

Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
            R+E+E   A         RL E+EA  ++ ++  E  ++ K   + EA  ++Q++ +E  
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380

Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
            +  +  ++ Q Q   ++++LQ+  ++ E +++ +  +    E+ +     E+  +R Q +
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440

Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
            A E+Q    E   + L  +A + E ++   Q+E ++L +Q+      Q  S+ + +   +
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1494

Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
            LA+ +K + +   E    K++  + ++E   + E+ E R+R+ E    + + V+ +T Q+
Sbjct: 1495 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550

Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
              +      R  F    A+ E SL+       QL+ E +   +++ E     E+ E+  E
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610

Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
              + K  E  +L +Q E   ++ +    E E++ +  + +  + G A             
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1657

Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
                      +E+ V   +L EQ  + Q+QL   T  + +  + ELIR        L ++
Sbjct: 1658 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1699

Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
             E      E++ + L E + +LQ+E A   QK       L  E   ++ +++V++A K  
Sbjct: 1700 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1751

Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
             E++  + +E+    K  L+    +  +L +E   L+   E  ++ + + E         
Sbjct: 1752 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808

Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
                      AI   ++ K E E+ L E     + L+ L     F  +  EE       +
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1868

Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
            +E RL QL     A D EL +    ++D   Q +     ++++I+ L+   E+  A    
Sbjct: 1869 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1921

Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
             +++L  ++  A+      T+ S+ +      L   R+ +L ++      R  E E +V 
Sbjct: 1922 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1969

Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
            +   SL  E+E      K  LE+ ++L    K      ++ RE+ ++ S + +++ +   
Sbjct: 1970 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2021

Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
            +              + L+AE    KA   + ++K ++LQ+ L  +++ +  L+ +    
Sbjct: 2022 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2064

Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
            R    EA+E     E+E      +V+E+++         +      +  +   K +    
Sbjct: 2065 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124

Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
              +   + A ++    ++   E+  +   Q   +K +  QEL    +       + ET+ 
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2178

Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
             K        LL EE   LKA      +++ S + E   S   Q  E+    +       
Sbjct: 2179 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2224

Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
                      I +E R      +  T  F ++    ++ V  E  ++    +      E 
Sbjct: 2225 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2268

Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
              ++Q++E  L +++A        K L  KMQ  +EA    +              LL  
Sbjct: 2269 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2312

Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
            Q+   +E++  L   + ++      +  G    LE   Q Q +E  A  E L+   R + 
Sbjct: 2313 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2369

Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
            +S  QA  A+ + ++   + E+  EK  +   E   Q+K + +  ++++       A  L
Sbjct: 2370 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2426

Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
            +E        +AEL+ E  + KL+ E  L      LK  E   ++ +    E   L  + 
Sbjct: 2427 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2473

Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
             SE+    + +  +E+EKAKL +  + +  + + L+   + Q+Q+       +EQ++Q L
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2526

Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
              S +  E++R  ++A+      +E+ + LE Q      LL  E  R+RE    L+ +  
Sbjct: 2527 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2584

Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
                H++  ++     ++      D L     + E +HS
Sbjct: 2585 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2623



 Score =  142 bits (359), Expect = 5e-33
 Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)

Query: 417  DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
            DI  ++E    R + +LR  LD+   ++  Q    +  Q  AQ          E+E   +
Sbjct: 969  DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1016

Query: 477  SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
              + ++   +++  +   + A   L  +L+ T  + E+++    + LE+   +    R  
Sbjct: 1017 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1076

Query: 531  EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
            +   E L    EQ++ A+    T+ E E+      KL  +A     T + L+ E+  A E
Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1136

Query: 581  SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
              + L+ +H   + EV  ++ ++  L +   AVL +  + ++ ELE+L  QL +  E   
Sbjct: 1137 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1195

Query: 638  ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
               + L++    + +I    L D+  +  + +Q   L  E+    +K+E  Q F K  + 
Sbjct: 1196 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1255

Query: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
              ++  +  ++    L+     +K  ++      + +E   LR    E  TL  +    +
Sbjct: 1256 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1315

Query: 746  QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
             E   + E  E+  +++  + +E+ A++EA    L+ +++  E   +      +E +   
Sbjct: 1316 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1369

Query: 806  LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
               ++ + ++ V  +E     E   D +QQ   + EE+++ R +   +E   +   ++ +
Sbjct: 1370 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1419

Query: 866  EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
                  L++++++   + + E   + +  A  E   LQ +     + +           A
Sbjct: 1420 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1465

Query: 926  ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
            +  +  E  E+   ++ ++ +  ++ ++EL+ R+   +E  ++K   +  L E    L+ 
Sbjct: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1521

Query: 986  EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
            + E+   R R+ E+     RA  VQ             +    R AE  +     SF E+
Sbjct: 1522 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1566

Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
            +  +             E S QE+ +   +  + +E+  RA Q +E ++ ++E     +E
Sbjct: 1567 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1606

Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
            +   R Q++A       + +  V Q +   + E +K            +EE  +E ++  
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1655

Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
            + E Q ++ +E  ++   K   L  G  Q+ ++ E                   L+ E  
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1701

Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
              +++     + E E   LQ         ++ +   L KV  E   LL      SK   +
Sbjct: 1702 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1753

Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
            +      E  ++ L  E   F  +  +   L  +    K +    + L +     Q  E 
Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1809

Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
            E +++     + E T    EAEI   +K     RL+ ++E        ++      ++D 
Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1869

Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
            +  +   + ++K  D  +E   + G+ E+T        + + Q+EEE+  +  S   A A
Sbjct: 1870 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1917

Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
             + EL     RI    E+T  SK         Q     ++E+                E 
Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977

Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
               Q +   +  E +  K +E  +   +   E  +++ L+          E K     + 
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2037

Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
            ++     +T    QS+ D++   +  A R        ++    E  +  RQ    E ++Q
Sbjct: 2038 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2097

Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
              E Q       QA   ++ ++ E +   + Q E   L ++ A  + ++     +E   R
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2157

Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
            ++  +E EL  L+ QL     +K  L  EL+    +       + +VEE+ F  +    +
Sbjct: 2158 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217

Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
               +   I +  R  + +  +   + L E  +    V E   R        S  +Q +A 
Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2270

Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
            L   +E + + +  + E+  +   +++   +        +   +++ ++  EL+Q   R 
Sbjct: 2271 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2322

Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
                  +  + E++   ++   Q   ++ LEA      E S++ E  K+   E+ R   R
Sbjct: 2323 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2376

Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
             +++A    K  EE+ E+LH    A ++    +                 E Q Q+    
Sbjct: 2377 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2422

Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
             +RL + +        ELE E++++Q+E +LL  + E M+      ++QLLQET+ L + 
Sbjct: 2423 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2472

Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
             L         +D L ++    E  +E++ ++  +L Q++  +   LR++ Q  ++Q+E+
Sbjct: 2473 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521

Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
             R+ L    E+A  R+HE +   +  Q+  QQL          E Q R+ E+L   L E+
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2568

Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
              +  E L   E+  R     +EE+   +          + +  T     D     A EA
Sbjct: 2569 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2618

Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
            +PE S +  L+ +  A   +E  I + EE
Sbjct: 2619 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2646



 Score =  140 bits (353), Expect = 2e-32
 Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)

Query: 424  QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
            QE   +LE     L  ++ Q  V MK  L  Q + +  ++           +RS+S  T 
Sbjct: 844  QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 892

Query: 484  NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
               + +    A++ L +  Q      +   +  G   E++   +R+        S   +Q
Sbjct: 893  RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 945

Query: 544  IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
            + ++ +  A++ES+     + +S ++D++ ++  A E+R           T ++++L + 
Sbjct: 946  LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 990

Query: 604  EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
            ++       R+AE Q  +AE+E L   +  L +  E++  L E       +  E     L
Sbjct: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1047

Query: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
             +   +Q+  L     +K++T+          +  L     +LK+ Q             
Sbjct: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1107

Query: 712  SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
            +  +++  Q    Q   + LR E +    + + +Q+   + ++  ++ +E+   L E++ 
Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167

Query: 772  QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
             + A+  + + E + L   L+ +   S +    +L   + +      +++I+ + + +++
Sbjct: 1168 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1220

Query: 831  DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
             +++Q  Q   L EEIE+        ++  +     +++    L+  K  LE   +  + 
Sbjct: 1221 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1279

Query: 888  EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
              K K+++ +E +  + ++  T   + +++  +   F++ETL   E  E+    L E+  
Sbjct: 1280 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1333

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
              +RE+L   +   +   QL + H +     E E K L+Q  ++  +R RE   +    +
Sbjct: 1334 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1392

Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
              ++Q    Q+    +  +   +R AE +         E S++ +E+++    + +    
Sbjct: 1393 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1443

Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
            +Q       L       +LRA   +E  + QK     ++E+   ++Q E+QR   + V  
Sbjct: 1444 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495

Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
                +       EK +AL +L+E  + A+E + +    E+++  Q+++     Q + +  
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1553

Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
                    +LQ   +       Q   S+  E+   A   E      +   +     E+ E
Sbjct: 1554 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606

Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
             +  R++++  +     L  +   +   L   +    K   ++    + +  E+ + + E
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1666

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
                 +  Q    E      + +L++ Q+L + + E +  E +  +  L+++L   ++  
Sbjct: 1667 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1721

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
             A     QKR +  +E      +  +  V+  S A+      S  +K+       +G F 
Sbjct: 1722 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1775

Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
             + EE   ++ L  E + Q QL EE A    +   A A++    +++   E T    +A 
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1831

Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
               ++++     ++   +   FQ             + L ++  +H            DI
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1869

Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
             E    +   S+    + K  +   +RQ    E  + ++ AS +     +   ++    +
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929

Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
            R       A + LR     ++E  R+ Q   +EE +R   +   + S+  E   + + + 
Sbjct: 1930 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984

Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
             LEE+E LK      R       + S+ Q Q   E      Q E +   F    KE+EL 
Sbjct: 1985 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044

Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
            +  + E    + L  E    R A ++A    ++   E  ++   VEE         L +S
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2098

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
            ++ Q+ A    ++ AE   K    E   R   E  ++     +D        +++ T  +
Sbjct: 2099 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158

Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
              ++ Q L        E D + + L+     RL+A   +     S+   +L   +V   E
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217

Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
            L +   R + +     L+ ++  +  L EE+   +Q+A E ++        A  + L E 
Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277

Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
             + ++  + +++ +E + A      L+AE + +Q+++EL   Q   ++ +   + QQL +
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337

Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
            ET+   +        +LE+  +AE+++              +D Q+  K  E ++ E++ 
Sbjct: 2338 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2396

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
            R     QEK T +  L  Q Q  +   E++R+ + E     E E++  QQE + L  QLK
Sbjct: 2397 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2450

Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
                     E QT + EQL     ++T    +  LS++     + +R   IE+ + ++ +
Sbjct: 2451 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2496

Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
            L Q  +  A   ++ + R+     + +  L  S+E   + + +A   + RK++E+  LE+
Sbjct: 2497 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2556

Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
            Q  Q  E L  +N+ +++    LE Q + +    +E+
Sbjct: 2557 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593



 Score =  122 bits (306), Expect = 7e-27
 Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)

Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
            A E    ++ + + QAE + +    K +  L  + E+    L   +     L  +LE+  
Sbjct: 994  ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1047

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
              +  +L+++   + ++ + ++ + L I+ +  A      H    K AQ +     E++ 
Sbjct: 1048 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1105

Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
                + KL+ Q +        +   + +R  +   E L          R+ E+E+  E +
Sbjct: 1106 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1159

Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
             +L +    +  +T +    L +    L++  +   A+ L A  Q      E++  M   
Sbjct: 1160 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1215

Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
            L ++     QL QE   L  ++R  E VE+ Q   +  +N   D+      EL++V  + 
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1269

Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
             L+ + +    K   ++G  S+I    +L T   +L +  S     +++  +++++ +  
Sbjct: 1270 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1328

Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
             +      Q++    +++ E  V AAL  Q QL      AK         +E E   +Q 
Sbjct: 1329 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1373

Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
              Q   +R +E   D       I E   Q+ +   + I  K  Q E AE++ L  E+++ 
Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433

Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
             ++  LE  E+++                            G   EL+ALRA +   +A+
Sbjct: 1434 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1466

Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
                +E+AE+L+ ++  +       + +L S+V+     A+EK   L+  +E  +Q  + 
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526

Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
                    ++ ++    Q    L+ +  +   ++  K A   +   Q E S +E    ++
Sbjct: 1527 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1582

Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
            Q  E+ E+  +  A AE    E+    E   LK    + ++L  EE    K++ Q    K
Sbjct: 1583 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1642

Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
            +             A   A + RE+   +                    +EG  ++  +A
Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1689

Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
                 +     LRA   +G Q   L E   +  +  +      +Q  E  L + +A +  
Sbjct: 1690 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1744

Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
            + + K            K + + EAE     +  E  +  R     A +Q  L E     
Sbjct: 1745 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1804

Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
                 E        A+G    L+   +    E +A  E L++     A +R  L E  A 
Sbjct: 1805 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1864

Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
            H A +  R   L++  +SE   Q+ L+E  ++Q++    +++ E+ ++K          S
Sbjct: 1865 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1911

Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
             EK     AEL+ EL + +   E TL++  K   ELEA R                 A E
Sbjct: 1912 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1957

Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
            +++ RE +  ++K  A   +  R  +   EE+E LK  +E  ++   +      +Q QL 
Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2017

Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
             E+ QK    E +   +  Q  E+     ELQ  L+ E+  + ++    +  R       
Sbjct: 2018 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072

Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
             A++Q+     QSR  +   + LK+  ++  +  ++      +L  E E+      Q  Q
Sbjct: 2073 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2132

Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
               + +Q     ++  ++   +  ++  +++ ++  L+ QLEE   Q   LD E QRL+ 
Sbjct: 2133 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2192

Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
               E  +Q  + EE+  S R+  + L++               L+ +IE E +      L
Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2232

Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
            I  +   T     L+   +K++ VA +   L   A E  +     +ED +  Q  + E +
Sbjct: 2233 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2289

Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
            L+         E+   V  +T   +  E LL+Q  EL    ++  +E  D   M  +L E
Sbjct: 2290 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2337

Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
            + + +++T           L      +  +++E E        + ++  RAE  A+ ++ 
Sbjct: 2338 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386

Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
            +AE   + L +T     E VTL
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTL 2408



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)

Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
            LL  LEQ  QE+         C      +  +SE++ +  Q+     R +   R    ++
Sbjct: 946  LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 992

Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
            P++E  +   +Q+++Q      E+  +      L  +  +EK++     S  A T + EL
Sbjct: 993  PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1045

Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
            E TL  + + ++ L A  LE K KT  + +     A E  ++ E Q    +         
Sbjct: 1046 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1103

Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
            E  K  L+ L+   E+Q+     L   L   +++    QQ+   +R +   +  E   + 
Sbjct: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1162

Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
            LE  Q +L    VR RE+      L   RE    L A LQ +    +    +P  D  + 
Sbjct: 1163 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1221

Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
            +++QL ++ + + E+    EK +      +Q +   KD ++   T + + E      KK 
Sbjct: 1222 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1281

Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
             ++QS  E + ++  + R    +L  L  Q ++ I +  ++ E E     + R    + L
Sbjct: 1282 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340

Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
             E    +L   R    + +   + + +    AK ++          E   +  +Q+ + +
Sbjct: 1341 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1396

Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
              +LQ L Q +   +Q +     A +   + ++E I  + LQL+    Q+G     +   
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456

Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
             +     E   RQ  E    +  Q+ +E    R   ++L  +++   +  A R+      
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1514

Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
                  ++A  A      +E E   + ++ L+ + + AEAE+   +A     +     S 
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574

Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
              EHV + +     LR E+ R+A
Sbjct: 1575 QEEHVAVAQ-----LREEAERRA 1592



 Score = 35.8 bits (81), Expect = 0.86
 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)

Query: 4    EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
            +E+ ++L+  K ++AQ         QR  +++ Q     S   ++ K R    S+    A
Sbjct: 2318 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2377

Query: 52   HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
              D    + Q  E+      R E     + T+++TL    + + H+     E  +E+   
Sbjct: 2378 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2436

Query: 111  ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
             +    E           K   L  EE   V      Q  Q         +  L  ++  
Sbjct: 2437 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2486

Query: 171  IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
            IE+   +LE++      +  Q  +E +   +Q +    +L A++++ARR + E       
Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2546

Query: 231  LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
              E+ Q+L+ Q +Q +               +LL  + Q L  Q QL E+ H
Sbjct: 2547 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2583



 Score = 35.0 bits (79), Expect = 1.5
 Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)

Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
            +QLN+    LQ  +++    KV +   E+ RDL   ++ I  L +D + +K  R  + EQ
Sbjct: 388  EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 447

Query: 2352 LNEVIEKLQQELANI 2366
            +   + +L + L  I
Sbjct: 448  MYRRVYRLHERLVAI 462


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  191 bits (486), Expect = 9e-48
 Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)

Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
            +++  EE   D +Q+   +  + Q+ +Q++E   QA  RQ E     + +++EEI+ +  
Sbjct: 1386 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1445

Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
            QL     QR   + E    +  R   EE EA K+ +    E+L  ++++ S   Q   + 
Sbjct: 1446 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1499

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
            + E+  +   E E  R+ +    + L   R   ++A  RL +  +E  +      ET   
Sbjct: 1500 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1556

Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
                   RS++++  +     +E  A ++  + EEH  V                     
Sbjct: 1557 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1589

Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
            +++ EE    +Q+   +  A  E + E E  +L  N + RL+   E++ +  S   ++ E
Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649

Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
              K    E  RE+ R+ +   ++++ +E   + L ++ +  E  A +   AE  +     
Sbjct: 1650 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1706

Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
            E    E+Q Q   + + RL++E   A+ + QELEAE  +++ E E+L             
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766

Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
               + K+ ++AEAG   ++L +E  +L     E + Q +   +D  +Q    E  + E++
Sbjct: 1767 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825

Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
            +   E  + K    + L+++    E + E++R+  +++A  R    +   Q    +E++L
Sbjct: 1826 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881

Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
                        Q R+     + L+ +     + L  + Q++ +I       EK      
Sbjct: 1882 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928

Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
            ELE  L      + DT +  E        +A+ E + + QL AE     R+A +R +K +
Sbjct: 1929 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1980

Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
               EE   Q +  L    EEV++L  ++E  ++      QE  ++ +L ++  +K   A 
Sbjct: 1981 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036

Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
            +++ A + Q +     +  Q +Q+++  +DQL  +              ++Q + +    
Sbjct: 2037 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093

Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
             + +EE   L +  E Q +     Q   ++ R+E  +   E   + Q E A + QK + +
Sbjct: 2094 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2150

Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
            A     E +  K   +  + +K  +EQ       E+T ++  L+ET+ + N L +EL  L
Sbjct: 2151 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2198

Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
            K E     + +S  E    SV V ++ LSK K  +E       L+  +N   F   EE  
Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2257

Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
            K   +  E   L + +  +A+  +L +     +D+ +Q     +ML++K+  +Q+    K
Sbjct: 2258 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2312

Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
              A L+ Q Q E  QE A+  Q+++   ++      Q   +       R+ E+ ++   L
Sbjct: 2313 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371

Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
             LR++E+                  E    ++H + +  +E+V + +   +++++   + 
Sbjct: 2372 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2431

Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
            ++L E   + +REKEK +  Q+ ++L+  +E   + ++     E +AL+   ++ K  L 
Sbjct: 2432 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2489

Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
                     K K E+L ++ + K   +       Q+ + Q R  L  + E+    + E E
Sbjct: 2490 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2549

Query: 2756 TEVQESKK 2763
              V+  ++
Sbjct: 2550 EGVRRKQE 2557



 Score =  167 bits (424), Expect = 1e-40
 Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)

Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
            PE       + S L+  + KL +  S ++  LE  K     +     R  Q A E L+  
Sbjct: 1040 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1094

Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
            EE         + +E  AV  +  E      + +K   + + Q+ T   D L  EL  A 
Sbjct: 1095 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1142

Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
               QE+    QQ   ER++   +     A+     Q +L +T+   +E  ++  Q    R
Sbjct: 1143 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1199

Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
            +        L+ D   +  +   +    +  + +  +Q QAL +++E+  + ++E Q   
Sbjct: 1200 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1258

Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
            +++   +   E+Q +  + QL+ V      P+ Q  SE   +E   L  H  E T   S+
Sbjct: 1259 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1318

Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
                       I+  +E + ++E   R  EQ         Q+ E+R+    VEA      
Sbjct: 1319 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1359

Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
               E   + + QAER+A +   R ++E+   EE     +++  +  EE+QQL    E + 
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1419

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
            +    + +  E+     ++++  + L ++ ++      +  L    A+  +E E +  Q 
Sbjct: 1420 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1478

Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
             E+  +L++Q         ++++++  R  E ++   +  +    R ++  ++ L E+  
Sbjct: 1479 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1527

Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
            +LQ                 +EEA+    Q +V  A ++  ALE    +A  E+   +  
Sbjct: 1528 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1570

Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
              E   ++ +      SL+ E  +V +++   E       +   + + E E  L    LK
Sbjct: 1571 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1623

Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
            + E                  L  RL Q E     K L   +  KQ ++ + +    G+ 
Sbjct: 1624 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1665

Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
            E + ++++ +  Q++ +++  A   +Q +L A QE  +       + +E E+   Q   Q
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1716

Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
            L E+EL     + +A T +  ELE+++ ++      L+  K + E   ++  EK K+ LE
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1776

Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
                 E    ++  +E  R     E  K   +L    EE       EA R  AE +A   
Sbjct: 1777 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1829

Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
            E    K +AE   +E   +   +  L +D +        Q   H A+ +E+L+ L K  +
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889

Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
            +E++  K          +    E L +K S   A+     L++               I+
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1938

Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
             N +    S+E  E+ +    ++   +E    E  +   + ++  E   R+   A+    
Sbjct: 1939 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 1994

Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
            EE   LKA ++  R       +E +   +LA   A    Q  E   + +     Q +  T
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054

Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
              Q   +  + RGE +E+A  +          A   E  +V +  E+  S  +    +++
Sbjct: 2055 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2103

Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
             +   E+ +A     ++ + L  + + +  R A+   ++   +  +D   E      +  
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2163

Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
            L +++ +     T    L  TD     N L++ +Q    E   A     + +      R 
Sbjct: 2164 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2221

Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
             + E+  L A++    R + L+ +  +++  QE  E     K  Q+ E    LS     A
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2276

Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
              L         Q++  +EKM+  ++++    T+L+ E  L  Q K L + +A RL+   
Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2336

Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
            +     L  +T       E ++ R+L+ + E E+ KL      R++ R +E+ +  +   
Sbjct: 2337 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2396

Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
            E   ++ L    L  Q+K  L ++ + I+ Q+  +DA+   E    LE +     ++ ++
Sbjct: 2397 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2454

Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
             ++ S   +  +    LQ +    QS   L  +D L + ++ +E++ +++ +L  +    
Sbjct: 2455 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2512

Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
             ++ + +  + +QQME++RQ   + + + +EA     +    ++ K E+LQ+  +++RQQ
Sbjct: 2513 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2569

Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
               L  E QRL+  +Q  ++Q
Sbjct: 2570 EELLAEENQRLREQLQLLEEQ 2590



 Score =  158 bits (399), Expect = 1e-37
 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)

Query: 153  SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
            +PT    +E  L GK  ++  L+   LE+++    V  GT+G ++ L+  E  +K+   +
Sbjct: 1046 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1104

Query: 207  ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
               L       A+L++ R + +     F  L ++   +Q++  + QQ      +      
Sbjct: 1105 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1164

Query: 258  STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
               A LL+  Q +L      Q++LE+    L  Y++  +      ++LQ+  +  E  Q 
Sbjct: 1165 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1221

Query: 314  KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
              + +S   +E++++++ ++EE+        +K  E +         + + + Q+V    
Sbjct: 1222 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1277

Query: 372  EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
            +++ +       K +    S  +E   L     EL     +  +F ++ ++RME+E +R 
Sbjct: 1278 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1336

Query: 430  LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
             EQ RAE                 L E + Q   Q ++E         EE+  R +  ++
Sbjct: 1337 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1396

Query: 473  NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
               +  S   + E+  +L   +  E+  K +   + +    +++EE+ ++   LE     
Sbjct: 1397 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1453

Query: 522  ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
                  E  AL+ + E+   +   ++E+ +R R+ + ++  +  +A   L++   +KAE 
Sbjct: 1454 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1511

Query: 576  VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
             +A E ++ L    EL+ +AE    +++   +E+ +     L+    S EAEL+  R   
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1569

Query: 630  LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
              S  E+ ++L+  L+ EH + + +L++      +QQ +    + E  +++E  Q + + 
Sbjct: 1570 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1626

Query: 688  LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
             +  + Q   E+++ K L Q+              E +K+ E   +E + +G   EQ V+
Sbjct: 1627 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1671

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            + +L  + LEKQ +  E   Q++ A   AE  +++         L+  T   +++R +  
Sbjct: 1672 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1719

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
            + +      +  ++E     ++ ++L+ +  ++  E+           E+ R+T   +++
Sbjct: 1720 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1773

Query: 856  NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
              E     ++EL EE A L  + ++        E+   +Q  E +     KL A+ E   
Sbjct: 1774 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1833

Query: 902  LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
            L+      +K K +  +      ED+ F    LE  E   +   ++ E+L ++ K    E
Sbjct: 1834 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1891

Query: 955  LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
            L ++   + + L+Q+      + EE+ +LK   E+ +    ELE+ +   R+    +  +
Sbjct: 1892 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947

Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
            +  + L+      +     R    +  +V KS   E +   + K + E +   +   +E 
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007

Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
              L           L+  Q +   +LQ E   +    +Q +  LQ   Q+        + 
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2061

Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
            +DQ+R   E  + +A    +E  + A+ E  +  +++ + E      +E           
Sbjct: 2062 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2120

Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
              KL+K   +E +   Q   + L +      + E + +  E              Q  R 
Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2166

Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
            + Q  QE + TL  ++ E  ++  +L   L ++  + T+  +         + E E  S+
Sbjct: 2167 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2219

Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
              QM  L  +   +  +++   L+D + T+  L+E+ ++++ +      +S   Q+    
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279

Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
             Q  E ++          L++++QAV E+T       L      + +  A+R       +
Sbjct: 2280 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2339

Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
             + +            +E     + LE + Q QLE       + + +A     E+SR   
Sbjct: 2340 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2383

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
              E  A   +  A    E+ +  E+   +     QT E    +   + + L + + E  +
Sbjct: 2384 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2443

Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
            E      +   +    + + T+ +E   ++ T  ++QS   E   S +   R +   + +
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2501

Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
            LE +        Q+L  + Q  QQ  E  RQ  +  ME  R  Q + +E ++R   +L Q
Sbjct: 2502 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2561

Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
              +     E L++E  + L E+L+ L++    +LA  E++      ++    NG +
Sbjct: 2562 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2617



 Score =  149 bits (376), Expect = 5e-35
 Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)

Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
            A E++  +R I E  DI  +LE    C +  +  L     + +  RE   R  E  KA+A
Sbjct: 962  AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1017

Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
                 G    +L  E EK++    E    A  +R +L+  +  LE     QV     +  
Sbjct: 1018 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1071

Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
            EK   +  + +  Q  E+ L    + L E QA+     E +  +  ++KL  Q +   P 
Sbjct: 1072 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1131

Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
            F  + + + R  +++   L+++  ++  E+   +E++ + ++     + + + R RELEQ
Sbjct: 1132 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190

Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
             L      +++  D       +A+     + Q+QA   A  +  +E    E+ L    EE
Sbjct: 1191 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1243

Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
            +E   E+V++         K+    +++ E +   +K  +E +    K+    S  +   
Sbjct: 1244 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1297

Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
                   +IQE        +E  T   Q +K  +         E +R +E + E L   Q
Sbjct: 1298 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1340

Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
               +R R  E+E     +EK Q++LA    +    A   ++E    + Q +VV  E+ A+
Sbjct: 1341 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1395

Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
            + Q +         K  ++E   ++ Q ++ E+ +  R+ E+ E+               
Sbjct: 1396 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1431

Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
             S+ + E E+ +    L++ E Q          +G +  L  R  + E+       E  +
Sbjct: 1432 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1484

Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
              +Q++D  Q + Q E E+  +     +   E++ A   + +++L+A +E  +  +  + 
Sbjct: 1485 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1543

Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
              +   +  ++   +  E EL S  ++   + ++LE  + E H ++   +E+ E   +  
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1603

Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
             E E+   E ++ LE  + K  E            +++S    E  K   E        G
Sbjct: 1604 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1663

Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
               E +A+R   +A + EL   ++ AE   ++ L  E  +  L+ +  Q        +E+
Sbjct: 1664 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1721

Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
            L+ L++E     Q     E++ A +   + + L+    ++ +     S+S ++ Q L   
Sbjct: 1722 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1778

Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
            AG    L  E +      E  +   Q  E+    Q   A  +L  +   I E   LK E 
Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1838

Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
             +A   LKE            +  E   +  LA  +A+Q R +                 
Sbjct: 1839 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1883

Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
               +SDS  +  +G+               L     F+ A+ G+ E          +A D
Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943

Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
            +   K +  L A      Q+ +  E    + E+   + ++  E    +RKA +  +  LK
Sbjct: 1944 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2001

Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
              + + +  RE    +S++  +   +   + L A               LQQ   +E+SV
Sbjct: 2002 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2061

Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
            L                   A  + E  A  +   V     L+Q  +EQ     + QAA 
Sbjct: 2062 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2121

Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
            E L+K   +      QA  A +  ++      ++ +K +++ L    Q +Q ++  ++++
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2180

Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
            L     +   L E+L   K    E   + +Q + EL  +++ Q + L +L+A R+E +++
Sbjct: 2181 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2238

Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
               +   ++T    Q+++ +++   E+         E A+L +  E D  +   L   + 
Sbjct: 2239 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2298

Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
             +K + +Q          LL+QQK+L  E  ++++  +     QL+EE QG         
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2358

Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
             R LE+    E  K+R+ EMS    R E +     + ++  G+   R  L +++ +    
Sbjct: 2359 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2418

Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
              E+Q+Q      E     I EL  E EK          K + +QT QQ +  ++ Q  +
Sbjct: 2419 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2478

Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
            ++  +E+++  + ++ + + ++K+E L        Q+  EE+++Q  +++ E QRL   M
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2538

Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
            +E ++++ E EE    ++   Q L +
Sbjct: 2539 EEARRRQHEAEEGVRRKQEELQQLEQ 2564



 Score =  146 bits (369), Expect = 3e-34
 Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)

Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
            L+       Q++   +  ++ +RE  RQ+Q   E ++        CQ   ++ ++     
Sbjct: 1209 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268

Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
              QL    ++                +E VI  Y D +T       L  + I+  ++ + 
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1328

Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
            R+E+E   A         RL E+EA  ++ ++  E  ++ K   + EA  ++Q++ +E  
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388

Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
            +  +  ++ Q Q   ++++LQ+  ++ E +++ +  +    E+ +     E+  +R Q +
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448

Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
            A E+Q    E   + L  +A + E ++   Q+E ++L +Q+      Q  S+ + +   +
Sbjct: 1449 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1502

Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
            LA+ +K + +   E    K++  + ++E   + E+ E R+R+ E    + + V+ +T Q+
Sbjct: 1503 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558

Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
              +      R  F    A+ E SL+       QL+ E +   +++ E     E+ E+  E
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618

Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
              + K  E  +L +Q E   ++ +    E E++ +  + +  + G A             
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1665

Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
                      +E+ V   +L EQ  + Q+QL   T  + +  + ELIR        L ++
Sbjct: 1666 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1707

Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
             E      E++ + L E + +LQ+E A   QK       L  E   ++ +++V++A K  
Sbjct: 1708 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1759

Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
             E++  + +E+    K  L+    +  +L +E   L+   E  ++ + + E         
Sbjct: 1760 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1816

Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
                      AI   ++ K E E+ L E     + L+ L     F  +  EE       +
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1876

Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
            +E RL QL     A D EL +    ++D   Q +     ++++I+ L+   E+  A    
Sbjct: 1877 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1929

Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
             +++L  ++  A+      T+ S+ +      L   R+ +L ++      R  E E +V 
Sbjct: 1930 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1977

Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
            +   SL  E+E      K  LE+ ++L    K      ++ RE+ ++ S + +++ +   
Sbjct: 1978 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2029

Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
            +              + L+AE    KA   + ++K ++LQ+ L  +++ +  L+ +    
Sbjct: 2030 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2072

Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
            R    EA+E     E+E      +V+E+++         +      +  +   K +    
Sbjct: 2073 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132

Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
              +   + A ++    ++   E+  +   Q   +K +  QEL    +       + ET+ 
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2186

Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
             K        LL EE   LKA      +++ S + E   S   Q  E+    +       
Sbjct: 2187 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2232

Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
                      I +E R      +  T  F ++    ++ V  E  ++    +      E 
Sbjct: 2233 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2276

Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
              ++Q++E  L +++A        K L  KMQ  +EA    +              LL  
Sbjct: 2277 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2320

Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
            Q+   +E++  L   + ++      +  G    LE   Q Q +E  A  E L+   R + 
Sbjct: 2321 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2377

Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
            +S  QA  A+ + ++   + E+  EK  +   E   Q+K + +  ++++       A  L
Sbjct: 2378 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2434

Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
            +E        +AEL+ E  + KL+ E  L      LK  E   ++ +    E   L  + 
Sbjct: 2435 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2481

Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
             SE+    + +  +E+EKAKL +  + +  + + L+   + Q+Q+       +EQ++Q L
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2534

Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
              S +  E++R  ++A+      +E+ + LE Q      LL  E  R+RE    L+ +  
Sbjct: 2535 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2592

Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
                H++  ++     ++      D L     + E +HS
Sbjct: 2593 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2631



 Score =  142 bits (359), Expect = 5e-33
 Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)

Query: 417  DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
            DI  ++E    R + +LR  LD+   ++  Q    +  Q  AQ          E+E   +
Sbjct: 977  DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1024

Query: 477  SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
              + ++   +++  +   + A   L  +L+ T  + E+++    + LE+   +    R  
Sbjct: 1025 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1084

Query: 531  EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
            +   E L    EQ++ A+    T+ E E+      KL  +A     T + L+ E+  A E
Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1144

Query: 581  SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
              + L+ +H   + EV  ++ ++  L +   AVL +  + ++ ELE+L  QL +  E   
Sbjct: 1145 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1203

Query: 638  ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
               + L++    + +I    L D+  +  + +Q   L  E+    +K+E  Q F K  + 
Sbjct: 1204 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1263

Query: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
              ++  +  ++    L+     +K  ++      + +E   LR    E  TL  +    +
Sbjct: 1264 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1323

Query: 746  QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
             E   + E  E+  +++  + +E+ A++EA    L+ +++  E   +      +E +   
Sbjct: 1324 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1377

Query: 806  LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
               ++ + ++ V  +E     E   D +QQ   + EE+++ R +   +E   +   ++ +
Sbjct: 1378 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1427

Query: 866  EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
                  L++++++   + + E   + +  A  E   LQ +     + +           A
Sbjct: 1428 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1473

Query: 926  ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
            +  +  E  E+   ++ ++ +  ++ ++EL+ R+   +E  ++K   +  L E    L+ 
Sbjct: 1474 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1529

Query: 986  EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
            + E+   R R+ E+     RA  VQ             +    R AE  +     SF E+
Sbjct: 1530 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1574

Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
            +  +             E S QE+ +   +  + +E+  RA Q +E ++ ++E     +E
Sbjct: 1575 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1614

Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
            +   R Q++A       + +  V Q +   + E +K            +EE  +E ++  
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1663

Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
            + E Q ++ +E  ++   K   L  G  Q+ ++ E                   L+ E  
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1709

Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
              +++     + E E   LQ         ++ +   L KV  E   LL      SK   +
Sbjct: 1710 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1761

Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
            +      E  ++ L  E   F  +  +   L  +    K +    + L +     Q  E 
Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1817

Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
            E +++     + E T    EAEI   +K     RL+ ++E        ++      ++D 
Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1877

Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
            +  +   + ++K  D  +E   + G+ E+T        + + Q+EEE+  +  S   A A
Sbjct: 1878 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1925

Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
             + EL     RI    E+T  SK         Q     ++E+                E 
Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985

Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
               Q +   +  E +  K +E  +   +   E  +++ L+          E K     + 
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2045

Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
            ++     +T    QS+ D++   +  A R        ++    E  +  RQ    E ++Q
Sbjct: 2046 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2105

Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
              E Q       QA   ++ ++ E +   + Q E   L ++ A  + ++     +E   R
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2165

Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
            ++  +E EL  L+ QL     +K  L  EL+    +       + +VEE+ F  +    +
Sbjct: 2166 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225

Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
               +   I +  R  + +  +   + L E  +    V E   R        S  +Q +A 
Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2278

Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
            L   +E + + +  + E+  +   +++   +        +   +++ ++  EL+Q   R 
Sbjct: 2279 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2330

Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
                  +  + E++   ++   Q   ++ LEA      E S++ E  K+   E+ R   R
Sbjct: 2331 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2384

Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
             +++A    K  EE+ E+LH    A ++    +                 E Q Q+    
Sbjct: 2385 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2430

Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
             +RL + +        ELE E++++Q+E +LL  + E M+      ++QLLQET+ L + 
Sbjct: 2431 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2480

Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
             L         +D L ++    E  +E++ ++  +L Q++  +   LR++ Q  ++Q+E+
Sbjct: 2481 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529

Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
             R+ L    E+A  R+HE +   +  Q+  QQL          E Q R+ E+L   L E+
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2576

Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
              +  E L   E+  R     +EE+   +          + +  T     D     A EA
Sbjct: 2577 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2626

Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
            +PE S +  L+ +  A   +E  I + EE
Sbjct: 2627 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2654



 Score =  140 bits (353), Expect = 2e-32
 Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)

Query: 424  QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
            QE   +LE     L  ++ Q  V MK  L  Q + +  ++           +RS+S  T 
Sbjct: 852  QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 900

Query: 484  NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
               + +    A++ L +  Q      +   +  G   E++   +R+        S   +Q
Sbjct: 901  RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 953

Query: 544  IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
            + ++ +  A++ES+     + +S ++D++ ++  A E+R           T ++++L + 
Sbjct: 954  LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 998

Query: 604  EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
            ++       R+AE Q  +AE+E L   +  L +  E++  L E       +  E     L
Sbjct: 999  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1055

Query: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
             +   +Q+  L     +K++T+          +  L     +LK+ Q             
Sbjct: 1056 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1115

Query: 712  SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
            +  +++  Q    Q   + LR E +    + + +Q+   + ++  ++ +E+   L E++ 
Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1175

Query: 772  QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
             + A+  + + E + L   L+ +   S +    +L   + +      +++I+ + + +++
Sbjct: 1176 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1228

Query: 831  DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
             +++Q  Q   L EEIE+        ++  +     +++    L+  K  LE   +  + 
Sbjct: 1229 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1287

Query: 888  EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
              K K+++ +E +  + ++  T   + +++  +   F++ETL   E  E+    L E+  
Sbjct: 1288 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1341

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
              +RE+L   +   +   QL + H +     E E K L+Q  ++  +R RE   +    +
Sbjct: 1342 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1400

Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
              ++Q    Q+    +  +   +R AE +         E S++ +E+++    + +    
Sbjct: 1401 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1451

Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
            +Q       L       +LRA   +E  + QK     ++E+   ++Q E+QR   + V  
Sbjct: 1452 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1503

Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
                +       EK +AL +L+E  + A+E + +    E+++  Q+++     Q + +  
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1561

Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
                    +LQ   +       Q   S+  E+   A   E      +   +     E+ E
Sbjct: 1562 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1614

Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
             +  R++++  +     L  +   +   L   +    K   ++    + +  E+ + + E
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1674

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
                 +  Q    E      + +L++ Q+L + + E +  E +  +  L+++L   ++  
Sbjct: 1675 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1729

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
             A     QKR +  +E      +  +  V+  S A+      S  +K+       +G F 
Sbjct: 1730 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1783

Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
             + EE   ++ L  E + Q QL EE A    +   A A++    +++   E T    +A 
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1839

Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
               ++++     ++   +   FQ             + L ++  +H            DI
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1877

Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
             E    +   S+    + K  +   +RQ    E  + ++ AS +     +   ++    +
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937

Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
            R       A + LR     ++E  R+ Q   +EE +R   +   + S+  E   + + + 
Sbjct: 1938 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992

Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
             LEE+E LK      R       + S+ Q Q   E      Q E +   F    KE+EL 
Sbjct: 1993 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052

Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
            +  + E    + L  E    R A ++A    ++   E  ++   VEE         L +S
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2106

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
            ++ Q+ A    ++ AE   K    E   R   E  ++     +D        +++ T  +
Sbjct: 2107 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166

Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
              ++ Q L        E D + + L+     RL+A   +     S+   +L   +V   E
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225

Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
            L +   R + +     L+ ++  +  L EE+   +Q+A E ++        A  + L E 
Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285

Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
             + ++  + +++ +E + A      L+AE + +Q+++EL   Q   ++ +   + QQL +
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345

Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
            ET+   +        +LE+  +AE+++              +D Q+  K  E ++ E++ 
Sbjct: 2346 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2404

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
            R     QEK T +  L  Q Q  +   E++R+ + E     E E++  QQE + L  QLK
Sbjct: 2405 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2458

Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
                     E QT + EQL     ++T    +  LS++     + +R   IE+ + ++ +
Sbjct: 2459 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2504

Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
            L Q  +  A   ++ + R+     + +  L  S+E   + + +A   + RK++E+  LE+
Sbjct: 2505 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2564

Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
            Q  Q  E L  +N+ +++    LE Q + +    +E+
Sbjct: 2565 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601



 Score =  122 bits (306), Expect = 7e-27
 Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)

Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
            A E    ++ + + QAE + +    K +  L  + E+    L   +     L  +LE+  
Sbjct: 1002 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1055

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
              +  +L+++   + ++ + ++ + L I+ +  A      H    K AQ +     E++ 
Sbjct: 1056 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1113

Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
                + KL+ Q +        +   + +R  +   E L          R+ E+E+  E +
Sbjct: 1114 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1167

Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
             +L +    +  +T +    L +    L++  +   A+ L A  Q      E++  M   
Sbjct: 1168 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1223

Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
            L ++     QL QE   L  ++R  E VE+ Q   +  +N   D+      EL++V  + 
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1277

Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
             L+ + +    K   ++G  S+I    +L T   +L +  S     +++  +++++ +  
Sbjct: 1278 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1336

Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
             +      Q++    +++ E  V AAL  Q QL      AK         +E E   +Q 
Sbjct: 1337 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1381

Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
              Q   +R +E   D       I E   Q+ +   + I  K  Q E AE++ L  E+++ 
Sbjct: 1382 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441

Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
             ++  LE  E+++                            G   EL+ALRA +   +A+
Sbjct: 1442 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1474

Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
                +E+AE+L+ ++  +       + +L S+V+     A+EK   L+  +E  +Q  + 
Sbjct: 1475 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1534

Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
                    ++ ++    Q    L+ +  +   ++  K A   +   Q E S +E    ++
Sbjct: 1535 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1590

Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
            Q  E+ E+  +  A AE    E+    E   LK    + ++L  EE    K++ Q    K
Sbjct: 1591 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1650

Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
            +             A   A + RE+   +                    +EG  ++  +A
Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1697

Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
                 +     LRA   +G Q   L E   +  +  +      +Q  E  L + +A +  
Sbjct: 1698 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1752

Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
            + + K            K + + EAE     +  E  +  R     A +Q  L E     
Sbjct: 1753 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1812

Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
                 E        A+G    L+   +    E +A  E L++     A +R  L E  A 
Sbjct: 1813 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1872

Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
            H A +  R   L++  +SE   Q+ L+E  ++Q++    +++ E+ ++K          S
Sbjct: 1873 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1919

Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
             EK     AEL+ EL + +   E TL++  K   ELEA R                 A E
Sbjct: 1920 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1965

Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
            +++ RE +  ++K  A   +  R  +   EE+E LK  +E  ++   +      +Q QL 
Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2025

Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
             E+ QK    E +   +  Q  E+     ELQ  L+ E+  + ++    +  R       
Sbjct: 2026 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080

Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
             A++Q+     QSR  +   + LK+  ++  +  ++      +L  E E+      Q  Q
Sbjct: 2081 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2140

Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
               + +Q     ++  ++   +  ++  +++ ++  L+ QLEE   Q   LD E QRL+ 
Sbjct: 2141 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2200

Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
               E  +Q  + EE+  S R+  + L++               L+ +IE E +      L
Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2240

Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
            I  +   T     L+   +K++ VA +   L   A E  +     +ED +  Q  + E +
Sbjct: 2241 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2297

Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
            L+         E+   V  +T   +  E LL+Q  EL    ++  +E  D   M  +L E
Sbjct: 2298 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2345

Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
            + + +++T           L      +  +++E E        + ++  RAE  A+ ++ 
Sbjct: 2346 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394

Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
            +AE   + L +T     E VTL
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTL 2416



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)

Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
            LL  LEQ  QE+         C      +  +SE++ +  Q+     R +   R    ++
Sbjct: 954  LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1000

Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
            P++E  +   +Q+++Q      E+  +      L  +  +EK++     S  A T + EL
Sbjct: 1001 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1053

Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
            E TL  + + ++ L A  LE K KT  + +     A E  ++ E Q    +         
Sbjct: 1054 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1111

Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
            E  K  L+ L+   E+Q+     L   L   +++    QQ+   +R +   +  E   + 
Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1170

Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
            LE  Q +L    VR RE+      L   RE    L A LQ +    +    +P  D  + 
Sbjct: 1171 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1229

Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
            +++QL ++ + + E+    EK +      +Q +   KD ++   T + + E      KK 
Sbjct: 1230 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1289

Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
             ++QS  E + ++  + R    +L  L  Q ++ I +  ++ E E     + R    + L
Sbjct: 1290 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1348

Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
             E    +L   R    + +   + + +    AK ++          E   +  +Q+ + +
Sbjct: 1349 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1404

Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
              +LQ L Q +   +Q +     A +   + ++E I  + LQL+    Q+G     +   
Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1464

Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
             +     E   RQ  E    +  Q+ +E    R   ++L  +++   +  A R+      
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1522

Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
                  ++A  A      +E E   + ++ L+ + + AEAE+   +A     +     S 
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582

Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
              EHV + +     LR E+ R+A
Sbjct: 1583 QEEHVAVAQ-----LREEAERRA 1600



 Score = 35.8 bits (81), Expect = 0.86
 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)

Query: 4    EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
            +E+ ++L+  K ++AQ         QR  +++ Q     S   ++ K R    S+    A
Sbjct: 2326 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2385

Query: 52   HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
              D    + Q  E+      R E     + T+++TL    + + H+     E  +E+   
Sbjct: 2386 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2444

Query: 111  ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
             +    E           K   L  EE   V      Q  Q         +  L  ++  
Sbjct: 2445 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2494

Query: 171  IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
            IE+   +LE++      +  Q  +E +   +Q +    +L A++++ARR + E       
Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2554

Query: 231  LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
              E+ Q+L+ Q +Q +               +LL  + Q L  Q QL E+ H
Sbjct: 2555 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2591



 Score = 35.0 bits (79), Expect = 1.5
 Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)

Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
            +QLN+    LQ  +++    KV +   E+ RDL   ++ I  L +D + +K  R  + EQ
Sbjct: 396  EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 455

Query: 2352 LNEVIEKLQQELANI 2366
            +   + +L + L  I
Sbjct: 456  MYRRVYRLHERLVAI 470


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  191 bits (486), Expect = 9e-48
 Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)

Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
            +++  EE   D +Q+   +  + Q+ +Q++E   QA  RQ E     + +++EEI+ +  
Sbjct: 1427 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1486

Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
            QL     QR   + E    +  R   EE EA K+ +    E+L  ++++ S   Q   + 
Sbjct: 1487 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1540

Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
            + E+  +   E E  R+ +    + L   R   ++A  RL +  +E  +      ET   
Sbjct: 1541 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1597

Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
                   RS++++  +     +E  A ++  + EEH  V                     
Sbjct: 1598 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1630

Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
            +++ EE    +Q+   +  A  E + E E  +L  N + RL+   E++ +  S   ++ E
Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690

Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
              K    E  RE+ R+ +   ++++ +E   + L ++ +  E  A +   AE  +     
Sbjct: 1691 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1747

Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
            E    E+Q Q   + + RL++E   A+ + QELEAE  +++ E E+L             
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807

Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
               + K+ ++AEAG   ++L +E  +L     E + Q +   +D  +Q    E  + E++
Sbjct: 1808 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866

Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
            +   E  + K    + L+++    E + E++R+  +++A  R    +   Q    +E++L
Sbjct: 1867 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922

Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
                        Q R+     + L+ +     + L  + Q++ +I       EK      
Sbjct: 1923 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969

Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
            ELE  L      + DT +  E        +A+ E + + QL AE     R+A +R +K +
Sbjct: 1970 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 2021

Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
               EE   Q +  L    EEV++L  ++E  ++      QE  ++ +L ++  +K   A 
Sbjct: 2022 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077

Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
            +++ A + Q +     +  Q +Q+++  +DQL  +              ++Q + +    
Sbjct: 2078 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134

Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
             + +EE   L +  E Q +     Q   ++ R+E  +   E   + Q E A + QK + +
Sbjct: 2135 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2191

Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
            A     E +  K   +  + +K  +EQ       E+T ++  L+ET+ + N L +EL  L
Sbjct: 2192 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2239

Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
            K E     + +S  E    SV V ++ LSK K  +E       L+  +N   F   EE  
Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2298

Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
            K   +  E   L + +  +A+  +L +     +D+ +Q     +ML++K+  +Q+    K
Sbjct: 2299 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2353

Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
              A L+ Q Q E  QE A+  Q+++   ++      Q   +       R+ E+ ++   L
Sbjct: 2354 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412

Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
             LR++E+                  E    ++H + +  +E+V + +   +++++   + 
Sbjct: 2413 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2472

Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
            ++L E   + +REKEK +  Q+ ++L+  +E   + ++     E +AL+   ++ K  L 
Sbjct: 2473 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2530

Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
                     K K E+L ++ + K   +       Q+ + Q R  L  + E+    + E E
Sbjct: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590

Query: 2756 TEVQESKK 2763
              V+  ++
Sbjct: 2591 EGVRRKQE 2598



 Score =  167 bits (424), Expect = 1e-40
 Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)

Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
            PE       + S L+  + KL +  S ++  LE  K     +     R  Q A E L+  
Sbjct: 1081 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1135

Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
            EE         + +E  AV  +  E      + +K   + + Q+ T   D L  EL  A 
Sbjct: 1136 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1183

Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
               QE+    QQ   ER++   +     A+     Q +L +T+   +E  ++  Q    R
Sbjct: 1184 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1240

Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
            +        L+ D   +  +   +    +  + +  +Q QAL +++E+  + ++E Q   
Sbjct: 1241 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1299

Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
            +++   +   E+Q +  + QL+ V      P+ Q  SE   +E   L  H  E T   S+
Sbjct: 1300 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1359

Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
                       I+  +E + ++E   R  EQ         Q+ E+R+    VEA      
Sbjct: 1360 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1400

Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
               E   + + QAER+A +   R ++E+   EE     +++  +  EE+QQL    E + 
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1460

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
            +    + +  E+     ++++  + L ++ ++      +  L    A+  +E E +  Q 
Sbjct: 1461 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1519

Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
             E+  +L++Q         ++++++  R  E ++   +  +    R ++  ++ L E+  
Sbjct: 1520 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1568

Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
            +LQ                 +EEA+    Q +V  A ++  ALE    +A  E+   +  
Sbjct: 1569 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1611

Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
              E   ++ +      SL+ E  +V +++   E       +   + + E E  L    LK
Sbjct: 1612 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1664

Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
            + E                  L  RL Q E     K L   +  KQ ++ + +    G+ 
Sbjct: 1665 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1706

Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
            E + ++++ +  Q++ +++  A   +Q +L A QE  +       + +E E+   Q   Q
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1757

Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
            L E+EL     + +A T +  ELE+++ ++      L+  K + E   ++  EK K+ LE
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1817

Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
                 E    ++  +E  R     E  K   +L    EE       EA R  AE +A   
Sbjct: 1818 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1870

Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
            E    K +AE   +E   +   +  L +D +        Q   H A+ +E+L+ L K  +
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930

Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
            +E++  K          +    E L +K S   A+     L++               I+
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1979

Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
             N +    S+E  E+ +    ++   +E    E  +   + ++  E   R+   A+    
Sbjct: 1980 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 2035

Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
            EE   LKA ++  R       +E +   +LA   A    Q  E   + +     Q +  T
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095

Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
              Q   +  + RGE +E+A  +          A   E  +V +  E+  S  +    +++
Sbjct: 2096 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2144

Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
             +   E+ +A     ++ + L  + + +  R A+   ++   +  +D   E      +  
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2204

Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
            L +++ +     T    L  TD     N L++ +Q    E   A     + +      R 
Sbjct: 2205 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2262

Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
             + E+  L A++    R + L+ +  +++  QE  E     K  Q+ E    LS     A
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2317

Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
              L         Q++  +EKM+  ++++    T+L+ E  L  Q K L + +A RL+   
Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2377

Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
            +     L  +T       E ++ R+L+ + E E+ KL      R++ R +E+ +  +   
Sbjct: 2378 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2437

Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
            E   ++ L    L  Q+K  L ++ + I+ Q+  +DA+   E    LE +     ++ ++
Sbjct: 2438 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2495

Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
             ++ S   +  +    LQ +    QS   L  +D L + ++ +E++ +++ +L  +    
Sbjct: 2496 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2553

Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
             ++ + +  + +QQME++RQ   + + + +EA     +    ++ K E+LQ+  +++RQQ
Sbjct: 2554 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2610

Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
               L  E QRL+  +Q  ++Q
Sbjct: 2611 EELLAEENQRLREQLQLLEEQ 2631



 Score =  158 bits (399), Expect = 1e-37
 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)

Query: 153  SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
            +PT    +E  L GK  ++  L+   LE+++    V  GT+G ++ L+  E  +K+   +
Sbjct: 1087 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1145

Query: 207  ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
               L       A+L++ R + +     F  L ++   +Q++  + QQ      +      
Sbjct: 1146 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1205

Query: 258  STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
               A LL+  Q +L      Q++LE+    L  Y++  +      ++LQ+  +  E  Q 
Sbjct: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1262

Query: 314  KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
              + +S   +E++++++ ++EE+        +K  E +         + + + Q+V    
Sbjct: 1263 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1318

Query: 372  EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
            +++ +       K +    S  +E   L     EL     +  +F ++ ++RME+E +R 
Sbjct: 1319 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1377

Query: 430  LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
             EQ RAE                 L E + Q   Q ++E         EE+  R +  ++
Sbjct: 1378 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1437

Query: 473  NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
               +  S   + E+  +L   +  E+  K +   + +    +++EE+ ++   LE     
Sbjct: 1438 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1494

Query: 522  ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
                  E  AL+ + E+   +   ++E+ +R R+ + ++  +  +A   L++   +KAE 
Sbjct: 1495 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1552

Query: 576  VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
             +A E ++ L    EL+ +AE    +++   +E+ +     L+    S EAEL+  R   
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1610

Query: 630  LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
              S  E+ ++L+  L+ EH + + +L++      +QQ +    + E  +++E  Q + + 
Sbjct: 1611 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1667

Query: 688  LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
             +  + Q   E+++ K L Q+              E +K+ E   +E + +G   EQ V+
Sbjct: 1668 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1712

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            + +L  + LEKQ +  E   Q++ A   AE  +++         L+  T   +++R +  
Sbjct: 1713 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1760

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
            + +      +  ++E     ++ ++L+ +  ++  E+           E+ R+T   +++
Sbjct: 1761 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1814

Query: 856  NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
              E     ++EL EE A L  + ++        E+   +Q  E +     KL A+ E   
Sbjct: 1815 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1874

Query: 902  LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
            L+      +K K +  +      ED+ F    LE  E   +   ++ E+L ++ K    E
Sbjct: 1875 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1932

Query: 955  LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
            L ++   + + L+Q+      + EE+ +LK   E+ +    ELE+ +   R+    +  +
Sbjct: 1933 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988

Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
            +  + L+      +     R    +  +V KS   E +   + K + E +   +   +E 
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048

Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
              L           L+  Q +   +LQ E   +    +Q +  LQ   Q+        + 
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2102

Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
            +DQ+R   E  + +A    +E  + A+ E  +  +++ + E      +E           
Sbjct: 2103 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2161

Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
              KL+K   +E +   Q   + L +      + E + +  E              Q  R 
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2207

Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
            + Q  QE + TL  ++ E  ++  +L   L ++  + T+  +         + E E  S+
Sbjct: 2208 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2260

Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
              QM  L  +   +  +++   L+D + T+  L+E+ ++++ +      +S   Q+    
Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320

Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
             Q  E ++          L++++QAV E+T       L      + +  A+R       +
Sbjct: 2321 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2380

Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
             + +            +E     + LE + Q QLE       + + +A     E+SR   
Sbjct: 2381 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2424

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
              E  A   +  A    E+ +  E+   +     QT E    +   + + L + + E  +
Sbjct: 2425 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2484

Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
            E      +   +    + + T+ +E   ++ T  ++QS   E   S +   R +   + +
Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2542

Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
            LE +        Q+L  + Q  QQ  E  RQ  +  ME  R  Q + +E ++R   +L Q
Sbjct: 2543 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2602

Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
              +     E L++E  + L E+L+ L++    +LA  E++      ++    NG +
Sbjct: 2603 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2658



 Score =  149 bits (376), Expect = 5e-35
 Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)

Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
            A E++  +R I E  DI  +LE    C +  +  L     + +  RE   R  E  KA+A
Sbjct: 1003 AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1058

Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
                 G    +L  E EK++    E    A  +R +L+  +  LE     QV     +  
Sbjct: 1059 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1112

Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
            EK   +  + +  Q  E+ L    + L E QA+     E +  +  ++KL  Q +   P 
Sbjct: 1113 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1172

Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
            F  + + + R  +++   L+++  ++  E+   +E++ + ++     + + + R RELEQ
Sbjct: 1173 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231

Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
             L      +++  D       +A+     + Q+QA   A  +  +E    E+ L    EE
Sbjct: 1232 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1284

Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
            +E   E+V++         K+    +++ E +   +K  +E +    K+    S  +   
Sbjct: 1285 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1338

Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
                   +IQE        +E  T   Q +K  +         E +R +E + E L   Q
Sbjct: 1339 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1381

Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
               +R R  E+E     +EK Q++LA    +    A   ++E    + Q +VV  E+ A+
Sbjct: 1382 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1436

Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
            + Q +         K  ++E   ++ Q ++ E+ +  R+ E+ E+               
Sbjct: 1437 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1472

Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
             S+ + E E+ +    L++ E Q          +G +  L  R  + E+       E  +
Sbjct: 1473 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1525

Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
              +Q++D  Q + Q E E+  +     +   E++ A   + +++L+A +E  +  +  + 
Sbjct: 1526 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1584

Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
              +   +  ++   +  E EL S  ++   + ++LE  + E H ++   +E+ E   +  
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1644

Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
             E E+   E ++ LE  + K  E            +++S    E  K   E        G
Sbjct: 1645 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1704

Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
               E +A+R   +A + EL   ++ AE   ++ L  E  +  L+ +  Q        +E+
Sbjct: 1705 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762

Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
            L+ L++E     Q     E++ A +   + + L+    ++ +     S+S ++ Q L   
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1819

Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
            AG    L  E +      E  +   Q  E+    Q   A  +L  +   I E   LK E 
Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1879

Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
             +A   LKE            +  E   +  LA  +A+Q R +                 
Sbjct: 1880 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924

Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
               +SDS  +  +G+               L     F+ A+ G+ E          +A D
Sbjct: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984

Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
            +   K +  L A      Q+ +  E    + E+   + ++  E    +RKA +  +  LK
Sbjct: 1985 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2042

Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
              + + +  RE    +S++  +   +   + L A               LQQ   +E+SV
Sbjct: 2043 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2102

Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
            L                   A  + E  A  +   V     L+Q  +EQ     + QAA 
Sbjct: 2103 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162

Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
            E L+K   +      QA  A +  ++      ++ +K +++ L    Q +Q ++  ++++
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2221

Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
            L     +   L E+L   K    E   + +Q + EL  +++ Q + L +L+A R+E +++
Sbjct: 2222 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2279

Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
               +   ++T    Q+++ +++   E+         E A+L +  E D  +   L   + 
Sbjct: 2280 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2339

Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
             +K + +Q          LL+QQK+L  E  ++++  +     QL+EE QG         
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2399

Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
             R LE+    E  K+R+ EMS    R E +     + ++  G+   R  L +++ +    
Sbjct: 2400 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2459

Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
              E+Q+Q      E     I EL  E EK          K + +QT QQ +  ++ Q  +
Sbjct: 2460 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2519

Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
            ++  +E+++  + ++ + + ++K+E L        Q+  EE+++Q  +++ E QRL   M
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2579

Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
            +E ++++ E EE    ++   Q L +
Sbjct: 2580 EEARRRQHEAEEGVRRKQEELQQLEQ 2605



 Score =  146 bits (369), Expect = 3e-34
 Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)

Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
            L+       Q++   +  ++ +RE  RQ+Q   E ++        CQ   ++ ++     
Sbjct: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309

Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
              QL    ++                +E VI  Y D +T       L  + I+  ++ + 
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369

Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
            R+E+E   A         RL E+EA  ++ ++  E  ++ K   + EA  ++Q++ +E  
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429

Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
            +  +  ++ Q Q   ++++LQ+  ++ E +++ +  +    E+ +     E+  +R Q +
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489

Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
            A E+Q    E   + L  +A + E ++   Q+E ++L +Q+      Q  S+ + +   +
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1543

Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
            LA+ +K + +   E    K++  + ++E   + E+ E R+R+ E    + + V+ +T Q+
Sbjct: 1544 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599

Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
              +      R  F    A+ E SL+       QL+ E +   +++ E     E+ E+  E
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659

Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
              + K  E  +L +Q E   ++ +    E E++ +  + +  + G A             
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1706

Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
                      +E+ V   +L EQ  + Q+QL   T  + +  + ELIR        L ++
Sbjct: 1707 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1748

Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
             E      E++ + L E + +LQ+E A   QK       L  E   ++ +++V++A K  
Sbjct: 1749 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1800

Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
             E++  + +E+    K  L+    +  +L +E   L+   E  ++ + + E         
Sbjct: 1801 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857

Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
                      AI   ++ K E E+ L E     + L+ L     F  +  EE       +
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1917

Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
            +E RL QL     A D EL +    ++D   Q +     ++++I+ L+   E+  A    
Sbjct: 1918 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1970

Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
             +++L  ++  A+      T+ S+ +      L   R+ +L ++      R  E E +V 
Sbjct: 1971 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 2018

Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
            +   SL  E+E      K  LE+ ++L    K      ++ RE+ ++ S + +++ +   
Sbjct: 2019 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2070

Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
            +              + L+AE    KA   + ++K ++LQ+ L  +++ +  L+ +    
Sbjct: 2071 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2113

Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
            R    EA+E     E+E      +V+E+++         +      +  +   K +    
Sbjct: 2114 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173

Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
              +   + A ++    ++   E+  +   Q   +K +  QEL    +       + ET+ 
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2227

Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
             K        LL EE   LKA      +++ S + E   S   Q  E+    +       
Sbjct: 2228 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2273

Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
                      I +E R      +  T  F ++    ++ V  E  ++    +      E 
Sbjct: 2274 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2317

Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
              ++Q++E  L +++A        K L  KMQ  +EA    +              LL  
Sbjct: 2318 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2361

Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
            Q+   +E++  L   + ++      +  G    LE   Q Q +E  A  E L+   R + 
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2418

Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
            +S  QA  A+ + ++   + E+  EK  +   E   Q+K + +  ++++       A  L
Sbjct: 2419 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2475

Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
            +E        +AEL+ E  + KL+ E  L      LK  E   ++ +    E   L  + 
Sbjct: 2476 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2522

Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
             SE+    + +  +E+EKAKL +  + +  + + L+   + Q+Q+       +EQ++Q L
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2575

Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
              S +  E++R  ++A+      +E+ + LE Q      LL  E  R+RE    L+ +  
Sbjct: 2576 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2633

Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
                H++  ++     ++      D L     + E +HS
Sbjct: 2634 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2672



 Score =  142 bits (359), Expect = 5e-33
 Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)

Query: 417  DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
            DI  ++E    R + +LR  LD+   ++  Q    +  Q  AQ          E+E   +
Sbjct: 1018 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1065

Query: 477  SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
              + ++   +++  +   + A   L  +L+ T  + E+++    + LE+   +    R  
Sbjct: 1066 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1125

Query: 531  EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
            +   E L    EQ++ A+    T+ E E+      KL  +A     T + L+ E+  A E
Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1185

Query: 581  SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
              + L+ +H   + EV  ++ ++  L +   AVL +  + ++ ELE+L  QL +  E   
Sbjct: 1186 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1244

Query: 638  ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
               + L++    + +I    L D+  +  + +Q   L  E+    +K+E  Q F K  + 
Sbjct: 1245 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1304

Query: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
              ++  +  ++    L+     +K  ++      + +E   LR    E  TL  +    +
Sbjct: 1305 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1364

Query: 746  QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
             E   + E  E+  +++  + +E+ A++EA    L+ +++  E   +      +E +   
Sbjct: 1365 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1418

Query: 806  LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
               ++ + ++ V  +E     E   D +QQ   + EE+++ R +   +E   +   ++ +
Sbjct: 1419 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1468

Query: 866  EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
                  L++++++   + + E   + +  A  E   LQ +     + +           A
Sbjct: 1469 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1514

Query: 926  ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
            +  +  E  E+   ++ ++ +  ++ ++EL+ R+   +E  ++K   +  L E    L+ 
Sbjct: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1570

Query: 986  EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
            + E+   R R+ E+     RA  VQ             +    R AE  +     SF E+
Sbjct: 1571 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1615

Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
            +  +             E S QE+ +   +  + +E+  RA Q +E ++ ++E     +E
Sbjct: 1616 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1655

Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
            +   R Q++A       + +  V Q +   + E +K            +EE  +E ++  
Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1704

Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
            + E Q ++ +E  ++   K   L  G  Q+ ++ E                   L+ E  
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1750

Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
              +++     + E E   LQ         ++ +   L KV  E   LL      SK   +
Sbjct: 1751 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1802

Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
            +      E  ++ L  E   F  +  +   L  +    K +    + L +     Q  E 
Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1858

Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
            E +++     + E T    EAEI   +K     RL+ ++E        ++      ++D 
Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1918

Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
            +  +   + ++K  D  +E   + G+ E+T        + + Q+EEE+  +  S   A A
Sbjct: 1919 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1966

Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
             + EL     RI    E+T  SK         Q     ++E+                E 
Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026

Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
               Q +   +  E +  K +E  +   +   E  +++ L+          E K     + 
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2086

Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
            ++     +T    QS+ D++   +  A R        ++    E  +  RQ    E ++Q
Sbjct: 2087 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2146

Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
              E Q       QA   ++ ++ E +   + Q E   L ++ A  + ++     +E   R
Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2206

Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
            ++  +E EL  L+ QL     +K  L  EL+    +       + +VEE+ F  +    +
Sbjct: 2207 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266

Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
               +   I +  R  + +  +   + L E  +    V E   R        S  +Q +A 
Sbjct: 2267 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2319

Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
            L   +E + + +  + E+  +   +++   +        +   +++ ++  EL+Q   R 
Sbjct: 2320 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2371

Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
                  +  + E++   ++   Q   ++ LEA      E S++ E  K+   E+ R   R
Sbjct: 2372 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2425

Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
             +++A    K  EE+ E+LH    A ++    +                 E Q Q+    
Sbjct: 2426 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2471

Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
             +RL + +        ELE E++++Q+E +LL  + E M+      ++QLLQET+ L + 
Sbjct: 2472 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2521

Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
             L         +D L ++    E  +E++ ++  +L Q++  +   LR++ Q  ++Q+E+
Sbjct: 2522 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570

Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
             R+ L    E+A  R+HE +   +  Q+  QQL          E Q R+ E+L   L E+
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2617

Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
              +  E L   E+  R     +EE+   +          + +  T     D     A EA
Sbjct: 2618 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2667

Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
            +PE S +  L+ +  A   +E  I + EE
Sbjct: 2668 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2695



 Score =  140 bits (353), Expect = 2e-32
 Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)

Query: 424  QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
            QE   +LE     L  ++ Q  V MK  L  Q + +  ++           +RS+S  T 
Sbjct: 893  QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 941

Query: 484  NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
               + +    A++ L +  Q      +   +  G   E++   +R+        S   +Q
Sbjct: 942  RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 994

Query: 544  IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
            + ++ +  A++ES+     + +S ++D++ ++  A E+R           T ++++L + 
Sbjct: 995  LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1039

Query: 604  EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
            ++       R+AE Q  +AE+E L   +  L +  E++  L E       +  E     L
Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1096

Query: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
             +   +Q+  L     +K++T+          +  L     +LK+ Q             
Sbjct: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1156

Query: 712  SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
            +  +++  Q    Q   + LR E +    + + +Q+   + ++  ++ +E+   L E++ 
Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1216

Query: 772  QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
             + A+  + + E + L   L+ +   S +    +L   + +      +++I+ + + +++
Sbjct: 1217 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1269

Query: 831  DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
             +++Q  Q   L EEIE+        ++  +     +++    L+  K  LE   +  + 
Sbjct: 1270 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1328

Query: 888  EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
              K K+++ +E +  + ++  T   + +++  +   F++ETL   E  E+    L E+  
Sbjct: 1329 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1382

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
              +RE+L   +   +   QL + H +     E E K L+Q  ++  +R RE   +    +
Sbjct: 1383 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1441

Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
              ++Q    Q+    +  +   +R AE +         E S++ +E+++    + +    
Sbjct: 1442 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1492

Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
            +Q       L       +LRA   +E  + QK     ++E+   ++Q E+QR   + V  
Sbjct: 1493 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1544

Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
                +       EK +AL +L+E  + A+E + +    E+++  Q+++     Q + +  
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1602

Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
                    +LQ   +       Q   S+  E+   A   E      +   +     E+ E
Sbjct: 1603 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1655

Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
             +  R++++  +     L  +   +   L   +    K   ++    + +  E+ + + E
Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1715

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
                 +  Q    E      + +L++ Q+L + + E +  E +  +  L+++L   ++  
Sbjct: 1716 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1770

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
             A     QKR +  +E      +  +  V+  S A+      S  +K+       +G F 
Sbjct: 1771 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1824

Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
             + EE   ++ L  E + Q QL EE A    +   A A++    +++   E T    +A 
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1880

Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
               ++++     ++   +   FQ             + L ++  +H            DI
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1918

Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
             E    +   S+    + K  +   +RQ    E  + ++ AS +     +   ++    +
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978

Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
            R       A + LR     ++E  R+ Q   +EE +R   +   + S+  E   + + + 
Sbjct: 1979 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033

Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
             LEE+E LK      R       + S+ Q Q   E      Q E +   F    KE+EL 
Sbjct: 2034 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093

Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
            +  + E    + L  E    R A ++A    ++   E  ++   VEE         L +S
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2147

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
            ++ Q+ A    ++ AE   K    E   R   E  ++     +D        +++ T  +
Sbjct: 2148 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207

Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
              ++ Q L        E D + + L+     RL+A   +     S+   +L   +V   E
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266

Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
            L +   R + +     L+ ++  +  L EE+   +Q+A E ++        A  + L E 
Sbjct: 2267 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2326

Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
             + ++  + +++ +E + A      L+AE + +Q+++EL   Q   ++ +   + QQL +
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2386

Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
            ET+   +        +LE+  +AE+++              +D Q+  K  E ++ E++ 
Sbjct: 2387 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2445

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
            R     QEK T +  L  Q Q  +   E++R+ + E     E E++  QQE + L  QLK
Sbjct: 2446 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2499

Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
                     E QT + EQL     ++T    +  LS++     + +R   IE+ + ++ +
Sbjct: 2500 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2545

Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
            L Q  +  A   ++ + R+     + +  L  S+E   + + +A   + RK++E+  LE+
Sbjct: 2546 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2605

Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
            Q  Q  E L  +N+ +++    LE Q + +    +E+
Sbjct: 2606 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642



 Score =  122 bits (306), Expect = 7e-27
 Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)

Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
            A E    ++ + + QAE + +    K +  L  + E+    L   +     L  +LE+  
Sbjct: 1043 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1096

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
              +  +L+++   + ++ + ++ + L I+ +  A      H    K AQ +     E++ 
Sbjct: 1097 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1154

Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
                + KL+ Q +        +   + +R  +   E L          R+ E+E+  E +
Sbjct: 1155 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1208

Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
             +L +    +  +T +    L +    L++  +   A+ L A  Q      E++  M   
Sbjct: 1209 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1264

Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
            L ++     QL QE   L  ++R  E VE+ Q   +  +N   D+      EL++V  + 
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1318

Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
             L+ + +    K   ++G  S+I    +L T   +L +  S     +++  +++++ +  
Sbjct: 1319 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1377

Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
             +      Q++    +++ E  V AAL  Q QL      AK         +E E   +Q 
Sbjct: 1378 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1422

Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
              Q   +R +E   D       I E   Q+ +   + I  K  Q E AE++ L  E+++ 
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482

Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
             ++  LE  E+++                            G   EL+ALRA +   +A+
Sbjct: 1483 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1515

Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
                +E+AE+L+ ++  +       + +L S+V+     A+EK   L+  +E  +Q  + 
Sbjct: 1516 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1575

Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
                    ++ ++    Q    L+ +  +   ++  K A   +   Q E S +E    ++
Sbjct: 1576 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1631

Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
            Q  E+ E+  +  A AE    E+    E   LK    + ++L  EE    K++ Q    K
Sbjct: 1632 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1691

Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
            +             A   A + RE+   +                    +EG  ++  +A
Sbjct: 1692 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1738

Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
                 +     LRA   +G Q   L E   +  +  +      +Q  E  L + +A +  
Sbjct: 1739 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1793

Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
            + + K            K + + EAE     +  E  +  R     A +Q  L E     
Sbjct: 1794 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1853

Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
                 E        A+G    L+   +    E +A  E L++     A +R  L E  A 
Sbjct: 1854 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1913

Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
            H A +  R   L++  +SE   Q+ L+E  ++Q++    +++ E+ ++K          S
Sbjct: 1914 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1960

Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
             EK     AEL+ EL + +   E TL++  K   ELEA R                 A E
Sbjct: 1961 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 2006

Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
            +++ RE +  ++K  A   +  R  +   EE+E LK  +E  ++   +      +Q QL 
Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2066

Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
             E+ QK    E +   +  Q  E+     ELQ  L+ E+  + ++    +  R       
Sbjct: 2067 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121

Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
             A++Q+     QSR  +   + LK+  ++  +  ++      +L  E E+      Q  Q
Sbjct: 2122 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2181

Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
               + +Q     ++  ++   +  ++  +++ ++  L+ QLEE   Q   LD E QRL+ 
Sbjct: 2182 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2241

Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
               E  +Q  + EE+  S R+  + L++               L+ +IE E +      L
Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2281

Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
            I  +   T     L+   +K++ VA +   L   A E  +     +ED +  Q  + E +
Sbjct: 2282 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2338

Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
            L+         E+   V  +T   +  E LL+Q  EL    ++  +E  D   M  +L E
Sbjct: 2339 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2386

Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
            + + +++T           L      +  +++E E        + ++  RAE  A+ ++ 
Sbjct: 2387 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435

Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
            +AE   + L +T     E VTL
Sbjct: 2436 QAEEIGEKLHRTELATQEKVTL 2457



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)

Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
            LL  LEQ  QE+         C      +  +SE++ +  Q+     R +   R    ++
Sbjct: 995  LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1041

Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
            P++E  +   +Q+++Q      E+  +      L  +  +EK++     S  A T + EL
Sbjct: 1042 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1094

Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
            E TL  + + ++ L A  LE K KT  + +     A E  ++ E Q    +         
Sbjct: 1095 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1152

Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
            E  K  L+ L+   E+Q+     L   L   +++    QQ+   +R +   +  E   + 
Sbjct: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1211

Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
            LE  Q +L    VR RE+      L   RE    L A LQ +    +    +P  D  + 
Sbjct: 1212 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1270

Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
            +++QL ++ + + E+    EK +      +Q +   KD ++   T + + E      KK 
Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330

Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
             ++QS  E + ++  + R    +L  L  Q ++ I +  ++ E E     + R    + L
Sbjct: 1331 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389

Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
             E    +L   R    + +   + + +    AK ++          E   +  +Q+ + +
Sbjct: 1390 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1445

Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
              +LQ L Q +   +Q +     A +   + ++E I  + LQL+    Q+G     +   
Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505

Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
             +     E   RQ  E    +  Q+ +E    R   ++L  +++   +  A R+      
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1563

Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
                  ++A  A      +E E   + ++ L+ + + AEAE+   +A     +     S 
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623

Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
              EHV + +     LR E+ R+A
Sbjct: 1624 QEEHVAVAQ-----LREEAERRA 1641



 Score = 35.8 bits (81), Expect = 0.86
 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)

Query: 4    EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
            +E+ ++L+  K ++AQ         QR  +++ Q     S   ++ K R    S+    A
Sbjct: 2367 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2426

Query: 52   HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
              D    + Q  E+      R E     + T+++TL    + + H+     E  +E+   
Sbjct: 2427 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2485

Query: 111  ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
             +    E           K   L  EE   V      Q  Q         +  L  ++  
Sbjct: 2486 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2535

Query: 171  IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
            IE+   +LE++      +  Q  +E +   +Q +    +L A++++ARR + E       
Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2595

Query: 231  LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
              E+ Q+L+ Q +Q +               +LL  + Q L  Q QL E+ H
Sbjct: 2596 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2632



 Score = 35.0 bits (79), Expect = 1.5
 Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)

Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
            +QLN+    LQ  +++    KV +   E+ RDL   ++ I  L +D + +K  R  + EQ
Sbjct: 437  EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 496

Query: 2352 LNEVIEKLQQELANI 2366
            +   + +L + L  I
Sbjct: 497  MYRRVYRLHERLVAI 511


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score =  182 bits (462), Expect = 6e-45
 Identities = 381/1857 (20%), Positives = 779/1857 (41%), Gaps = 315/1857 (16%)

Query: 301  LQEKIKVYEMEQ-DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359
            LQ+ ++  E+ +  K V+N  ++ + ++++ I+ L  +    EK  +E + +    +K L
Sbjct: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGR---HEKFKVESEQQYFEIEKRL 61

Query: 360  GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419
               QE++V + +E ++++LEL     + +  +E+ K+L    E  Q RN           
Sbjct: 62   SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL----EIAQDRNIA--------- 108

Query: 420  QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHKGEMENALRS 477
              ++ +  R  E+L AE            K++LIR  + ++Q  E  T     +   L+ 
Sbjct: 109  --IQSQFTRTKEELEAE------------KRDLIRTNERLSQELEYLTEDVKRLNEKLKE 154

Query: 478  YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEK---------LKEELGLILEEKCALQR 528
             SN T  E Q+KL  +  +++++K ++   ++EK         L  EL    +E  AL R
Sbjct: 155  -SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213

Query: 529  QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST-VEDLKAEIVSASESRKELEL 587
            +  + + EL  + E  +     + EQ + L  +++ L   VEDL  ++  A E +  +E 
Sbjct: 214  EKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE 273

Query: 588  KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647
            K   E+ N  IKL  L K  +A  D  A+S E          L     E +K  +D    
Sbjct: 274  KFHNEL-NAHIKLSNLYK--SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD---- 326

Query: 648  HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS------- 700
            H + +E+ KD +     ++I  L+ E+    + +   K        + +  +S       
Sbjct: 327  HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVA 386

Query: 701  -------KLKDLQQSLVNSKSE---------EMTLQINELQKEIE----ILRQEEKEKGT 740
                   KL +L  + V ++ +          +   ++E+ KE+E    IL+++ +E   
Sbjct: 387  KIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYER 446

Query: 741  LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE 800
             ++ V  L +K   LE+ MKE +  LQE   +   ++S+L+ + + +E  +K    +SQ+
Sbjct: 447  AQKAVASLSVK---LEQAMKEIQR-LQEDTDKANKQSSVLERDNRRMEIQVK---DLSQQ 499

Query: 801  ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
             R++ ++  +++    + ++E+      + D+      +++ +   RN            
Sbjct: 500  IRVLLMELEEARGNHVIRDEEVS-----SADISSSSEVISQHLVSYRNI----------- 543

Query: 861  YQELQEEYACLLKVKDDLEDSKNKQELEYKS--------KLK-ALNEELHLQRINPTTVK 911
             +ELQ++   LL    +L +++ ++E E  S        KL+ AL E   L++     ++
Sbjct: 544  -EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602

Query: 912  MKSSVFDE-DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS--------DL 962
            +  S+  + D   +  +   G  +    + L +    +  ++   SQ +S        + 
Sbjct: 603  LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662

Query: 963  SEQLKQKHGEISFLNEEVKSLKQEK-EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
            +E ++ K   +  L E  ++ K+EK E   ++  +LE +    +  +++S +T++S+ LD
Sbjct: 663  TEAIEAK-AALKQLQEIFENYKKEKAENEKIQNEQLEKL--QEQVTDLRSQNTKISTQLD 719

Query: 1022 GV---VTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSV 1078
                   M     EG   ++        K+    +            KQEQ+I      +
Sbjct: 720  FASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ------------KQEQIINTMTQDL 767

Query: 1079 TKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEA-------QRICLSLVYSTHVDQV 1131
               +   A      + L+KE  +LK  +  L  Q E+       Q + L+ + +  +  +
Sbjct: 768  RGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT--IQGI 825

Query: 1132 REYMENEKDKALCS----LKEELIFAQEEKIKELQKIH----QLELQTMKTQETGDEGKP 1183
             E  E E  + L S    L+ E+   +++   E+++ H     L++Q + T+   D    
Sbjct: 826  LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885

Query: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAE--DKENSGDYISENEDPE 1241
            LHL   +L K   +E +   Q L ++  +  + + +     +  +KE+  D +S+    E
Sbjct: 886  LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945

Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
             Q     V D +E + T  + V E+Y  ++   T L                EE+L KE+
Sbjct: 946  EQ-----VNDLKERLKTSTSNV-EQYQAMV---TSL----------------EESLNKEK 980

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
                    Q+T  E++  N + +L    + + T+LE+++ E+E     LQ   +   ++ 
Sbjct: 981  --------QVT--EEVRKNIEVRLKESAEFQ-TQLEKKLMEVEKEKQELQDDKRRAIESM 1029

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
            E ++  L+K L +V            + +  E  A+R                       
Sbjct: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC--------------------- 1068

Query: 1422 VKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVC 1481
             +E+  I    + +Y+ +L    A V  ++  A  Q ++++ +    E T    ++  + 
Sbjct: 1069 -QEQAKIAVEAQNKYERELMLHAADV-EALQAAKEQVSKMASVRQHLEETTQKAESQLL- 1125

Query: 1482 QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPES 1541
            + +  +    ++ +D++        D++  ++ + L  ++ +   +++ S  +    P +
Sbjct: 1126 ECKASWEERERMLKDEVSKCVCRCEDLE--KQNRLLHDQIEKLSDKVVASVKEGVQGPLN 1183

Query: 1542 KDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEH 1601
                +++SEE  S+++   + + I  E  ++      +      Q+E +R         +
Sbjct: 1184 ----VSLSEEGKSQEQILEILRFIRREKEIA------ETRFEVAQVESLR---------Y 1224

Query: 1602 QQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELE 1661
            +Q  ELL +      +    ++E++Q   K + +        +  N+V E  ++L EE E
Sbjct: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284

Query: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNER 1721
             L+Q  L   +    +L       Q  N    E       EK+L    EDV      N+ 
Sbjct: 1285 RLEQ-DLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL--LEEDVKRWKARNQH 1341

Query: 1722 YALQKAN---NRLLKILLEVVKTTAAVE---ETIGRHVLGILDRSSKSQSSASLIWRSEA 1775
               Q+ +       K+L E    T  ++   E IGR       ++  ++S+ASL      
Sbjct: 1342 LVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRL------KAEIARSNASLTNNQNL 1395

Query: 1776 EASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEI 1835
              S+K  +++   R   E+I      D+    I++  KV        + + +    G   
Sbjct: 1396 IQSLKEDLNK--VRTEKETIQK----DLDAKIIDIQEKV--------KTITQVKKIGRRY 1441

Query: 1836 DPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEATESL 1893
              + EEL        +A  +K++E  +++S   Q +H  V + + ++E+  Q +  ++SL
Sbjct: 1442 KTQYEEL--------KAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSL 1493

Query: 1894 KCQ-EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952
            + Q E L++ L E+                      + + L E+ +Q ++++  RL Q+L
Sbjct: 1494 ESQVENLQKTLSEKE--------------------TEARNLQEQTVQLQSEL-SRLRQDL 1532

Query: 1953 LCASNRLQELEAEQQQIQEERELLSRQKEAMK---AEAGPVEQQLLQETEKLMKEKLEVQ 2009
                +R  + E  +QQI E+ E   +   A K   A    V+ QL +E E+L +    + 
Sbjct: 1533 ---QDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589

Query: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDLRQQ--NQALEKQ 2061
             Q    +D+L  ++ AL+   E ++SR    +   QE++ E  D  Q+  N+  E+Q
Sbjct: 1590 QQ----KDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQ 1642



 Score =  177 bits (450), Expect = 1e-43
 Identities = 348/1733 (20%), Positives = 733/1733 (42%), Gaps = 232/1733 (13%)

Query: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE----EQVSRFIELEQE-- 2043
            V QQ+L+ TE L K    VQ + EK   D Q ++  L+   E    E   ++ E+E+   
Sbjct: 4    VLQQVLERTE-LNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS 62

Query: 2044 -KNTELMDLRQQNQALEKQLEKMR---KFLDEQAIDREHERD---VFQQEIQKLEQQLKV 2096
                 L++  ++ Q+L  +LEK+    K L E+  + E  +D     Q +  + +++L+ 
Sbjct: 63   HSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEA 122

Query: 2097 VPR-FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
              R     +E  ++E+E L   +K   +K  E   +K +LQ  + E       +++R + 
Sbjct: 123  EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182

Query: 2156 LEQ--ALLVSADTF------QKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITN 2207
            LEQ   LL S +T+       K ++    G  +    L L+  L+ +++ + R E+++  
Sbjct: 183  LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNG 242

Query: 2208 LE---EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2264
            L+   E L++  E+L  K +E ++    +E +         +L    K   DD E    A
Sbjct: 243  LKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE----A 298

Query: 2265 IKESDAMSTQDQHVLF---GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321
                   + ++ H L    G+  + IQ+  +E++Q  +Q+ K +   KI    K +E  N
Sbjct: 299  KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK-EMLEKIGRLEKELENAN 357

Query: 2322 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
            +L+   + +   L  ++          + ++ +   KL  EL N   +T         E 
Sbjct: 358  DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL-TELYNAYVETQDQLLLEKLEN 416

Query: 2382 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2441
              +   LD ++ E  A    ++   EE    +  +   + K+ Q  +E+  L+ + +   
Sbjct: 417  KRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476

Query: 2442 KIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFE-ENGKGSIINLETR 2500
            K  S+           L +D   +E+      +K L  Q      E E  +G+ +  +  
Sbjct: 477  KQSSV-----------LERDNRRMEI-----QVKDLSQQIRVLLMELEEARGNHVIRDEE 520

Query: 2501 LLQLESTVSAKDL-ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQI 2559
            +   + + S++ + +    Y+ I+++Q+Q Q    +  +++   ++  E++  ++ ++++
Sbjct: 521  VSSADISSSSEVISQHLVSYRNIEELQQQNQ-RLLVALRELGETREREEQETTSSKITEL 579

Query: 2560 QLEAVQEYAKFCQ-------DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELE 2612
            QL+      +  Q         Q + S   + ++  +   +   +   + A +L    L 
Sbjct: 580  QLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLA 639

Query: 2613 SQVVEMHTS-LILEKEQVEIAEK-NVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE 2670
            S      TS  +     V + E    +E +  L +LQ++ E  +K++ E EK ++ Q  +
Sbjct: 640  STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK 699

Query: 2671 VLKTTTELFHSNEESGFFNELEALRAESV-----ATKAELASYKEKAEKLQEELLVKETN 2725
            + +  T+L   N +     +  + R E +       + E+ S  E+ +KL      +E  
Sbjct: 700  LQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQI 759

Query: 2726 MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS---KSIASQT 2782
            + ++ +DL    + LA A+ +   L+KE E          M +   ++LS   +S+ ++ 
Sbjct: 760  INTMTQDLRGANEKLAVAEVRAENLKKEKE----------MLKLSEVRLSQQRESLLAEQ 809

Query: 2783 DGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIE-KMQELHA----A 2837
             G   + ++ QT Q +++ +  +   +     E++   IS   +K+E ++++ H      
Sbjct: 810  RGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNL 869

Query: 2838 EILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT 2897
            ++  ++++   +TET    H    +LLK     +  + Q L + E               
Sbjct: 870  DVQLLDTKRQLDTET--NLHLNTKELLKNAQKEIATLKQHLSNMEVQ------------- 914

Query: 2898 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV 2957
                +S S    G+G         D+ S+ R  ++E   +   +++K     V      V
Sbjct: 915  ---VASQSSQRTGKGQPSNKEDVDDLVSQLR--QTEEQVNDLKERLKTSTSNVEQYQAMV 969

Query: 2958 LSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHE 3017
             SL ES   +      +QV+E   E RK   N    LK+   + Q Q E ++ +  +  +
Sbjct: 970  TSLEESLNKE------KQVTE---EVRK---NIEVRLKE-SAEFQTQLEKKLMEVEKEKQ 1016

Query: 3018 SFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQR--IQEQGVEY 3075
               D +   + +++Q  L E    L++ + E+       +  L N  + R   QEQ    
Sbjct: 1017 ELQDDKRRAIESMEQQ-LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA--- 1072

Query: 3076 QAAMECLQKADRRSLL--SEIQALHA--QMNGRKITLKR--EQESEKPSQELLEYNIQ-- 3127
            + A+E   K +R  +L  ++++AL A  +   +  ++++  E+ ++K   +LLE      
Sbjct: 1073 KIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWE 1132

Query: 3128 --------------------QKQSQMLEMQVE------LSSMKDRA-----TELQEQLSS 3156
                                +KQ+++L  Q+E      ++S+K+         L E+  S
Sbjct: 1133 ERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKS 1192

Query: 3157 EKMVVAELK-----SELAQTKLELETTLKAQHKHL-----KELEAFRLEVKDKTDEVHLL 3206
            ++ ++  L+      E+A+T+ E+      +++       +EL+  +  +  + ++V + 
Sbjct: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVT 1252

Query: 3207 NDTLASEQ---KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL- 3262
              T+A  +   KK+  +   +E  K  L   +ER +++L+ ++      K R L+L++L 
Sbjct: 1253 AKTMAQHEELMKKTETMNVVMETNK-MLREEKERLEQDLQQMQ-----AKVRKLELDILP 1306

Query: 3263 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL------------ELQVLLESEKV--- 3307
            L++    L+E    +++++ L +  +   + RN             E + LL  ++V   
Sbjct: 1307 LQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTK 1366

Query: 3308 RIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK------ELQKQL-------EE 3354
            RI++++  + R +   A+  +S    Q+      EDL K       +QK L       +E
Sbjct: 1367 RIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQE 1426

Query: 3355 KHSRIVELLNETEKYKLDSLQTRQQMEK-------------DRQVHRKTLQTEQEANTEG 3401
            K   I ++     +YK    + + Q +K             ++ V  + +Q  +E   + 
Sbjct: 1427 KVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA 1486

Query: 3402 QKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILY 3461
            + K   L+S+VE+LQ+ L EK  +   L  +  +LQ  +   ++   +R  + E  R   
Sbjct: 1487 ETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQI 1546

Query: 3462 QNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM----IRQ 3517
                E T  ++ + +++   L    +  TKE+   +L + NG       EL++    ++ 
Sbjct: 1547 TEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENE--ELKQRNGALDQQKDELDVRITALKS 1604

Query: 3518 KLQCVASKLQVLPQKASER-LQFETADDEDFIWVQENIDEIILQLQKLTGQQG 3569
            + +   S+L+   ++  ER L+      E    V E   +I L+    +G++G
Sbjct: 1605 QYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG 1657



 Score =  165 bits (418), Expect = 7e-40
 Identities = 336/1710 (19%), Positives = 723/1710 (42%), Gaps = 235/1710 (13%)

Query: 1838 ENEELMLNISSRLQAAVEKLLEAISETSS-QLEHAKVT-QTELMRESFRQKQEA------ 1889
            E+E+    I  RL  + E+L+    E  S +LE  K+  Q + + E  ++ + A      
Sbjct: 49   ESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIA 108

Query: 1890 --TESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
              ++  + +EEL     +  R  E+L+ EL         Y  E     +++ EK    + 
Sbjct: 109  IQSQFTRTKEELEAEKRDLIRTNERLSQELE--------YLTEDV---KRLNEKLKESNT 157

Query: 1948 LEQELLCASNRLQ----ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK 2003
             + EL    + LQ     ++  ++++++E+ELL  Q   +  E      +LL    +   
Sbjct: 158  TKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGN 217

Query: 2004 EKLEVQCQAEKVRDD---LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEK 2060
            E LE++C  E  +++   L++Q+  L+    E + + +E   +  T+L + ++Q  ++E+
Sbjct: 218  EILELKCNLENKKEEVSRLEEQMNGLKTS-NEHLQKHVE---DLLTKLKEAKEQQASMEE 273

Query: 2061 QLE-------KMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
            +         K+       A D E + +   + +++L + LK         +    EVEQ
Sbjct: 274  KFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQ 333

Query: 2114 LANHL-KEKTDKCSEL---------LLSKEQLQRDIQERNE------------EIEKLEF 2151
              + + KE  +K   L         LLS  + +  I    E            +I K   
Sbjct: 334  SKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGM 393

Query: 2152 RVRELEQALLVSAD--TFQKVEDR---KHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206
            ++ EL  A + + D    +K+E++   K+   +  + E    + L+ +R+  +R +K + 
Sbjct: 394  KLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPI-LKRQREEYERAQKAVA 452

Query: 2207 NLEEQLEQFREELENKNEEVQQLHMQ---LEIQKKESTTRLQELEQENKLFKDDMEKL-G 2262
            +L  +LEQ  +E++   E+  + + Q   LE   +    ++++L Q+ ++   ++E+  G
Sbjct: 453  SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512

Query: 2263 LAIKESDAMSTQDQHVLFGKFAQIIQEKEV------EIDQLNEQVTKLQQQLKITTDNKV 2316
              +   + +S+ D        +++I +  V      E+ Q N+++    ++L  T + + 
Sbjct: 513  NHVIRDEEVSSAD----ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE 568

Query: 2317 IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2376
             E  +  I +L+ ++E  +++ E ++++R+ +++ ++ ++ +       + Q T +   +
Sbjct: 569  QETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV---A 625

Query: 2377 LSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE 2436
            +   A SL         ++ +  Q V T             E    + QL +   + K+E
Sbjct: 626  IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE 685

Query: 2437 RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG---S 2493
            +   EKIQ       N  ++ L +   +L    T+ + +       ++  ++N +G    
Sbjct: 686  KAENEKIQ-------NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRRE 738

Query: 2494 IINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAA 2553
            I +L  R  +L +T   ++       + I  M +  +   E L    V  + + +EK   
Sbjct: 739  ITSLHERNQKLTATTQKQE-------QIINTMTQDLRGANEKLAVAEVRAENLKKEKEML 791

Query: 2554 ALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELES 2613
             L S+++L   +E     Q  Q +      TN+Q +  + E         L+ +I +LE 
Sbjct: 792  KL-SEVRLSQQRESLLAEQRGQNLL----LTNLQTIQGILERSETETKQRLSSQIEKLEH 846

Query: 2614 QVVEMHTSLILEKEQVEIAEKN----VLEKEKKL-------LELQKLLEGNEKKQREKEK 2662
            ++  +   L  E EQ     +N    +L+ +++L       L  ++LL+  +K+    ++
Sbjct: 847  EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQ 906

Query: 2663 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVK 2722
              S  +V+V   +++     + S    +++ L ++   T+ ++   KE+ +     +   
Sbjct: 907  HLSNMEVQVASQSSQRTGKGQPSN-KEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQY 965

Query: 2723 ETNMTSLQKDLSQVRDHLAEAKEKLSILEKED-ETEVQESKKACMFEPLPIKLS------ 2775
            +  +TSL++ L++ +    E ++ + +  KE  E + Q  KK    E    +L       
Sbjct: 966  QAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRA 1025

Query: 2776 -KSIASQTDGTLKISSS--NQTPQILVK-NAGIQINLQSECSSEEVTEIISQFTEKIEKM 2831
             +S+  Q     K  SS  N+  + L + +  +    Q+    +E  +I  +   K E+ 
Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERE 1085

Query: 2832 QELHAAEILDMES------------RHISETETLKREHYV---------AVQLLKEECGT 2870
              LHAA++  +++            +H+ ET T K E  +           ++LK+E   
Sbjct: 1086 LMLHAADVEALQAAKEQVSKMASVRQHLEET-TQKAESQLLECKASWEERERMLKDEVS- 1143

Query: 2871 LKAVIQCLRSKEGSSIPELAHS--DAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGR 2928
             K V +C   ++      L H   +    + + S   G      +         ++ EG+
Sbjct: 1144 -KCVCRC---EDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNV--------SLSEEGK 1191

Query: 2929 GEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYI 2988
             +E       F ++ K +      E  QV SL      +  +  +Q++ +    ER+   
Sbjct: 1192 SQEQILEILRFIRREKEIAE-TRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ 1250

Query: 2989 NTISSLKDLITKMQLQREAEVYD-SSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3047
             T    K +    +L ++ E  +   ++++   + +  L   LQQ+  + R       + 
Sbjct: 1251 VT---AKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVR-------KL 1300

Query: 3048 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT 3107
            EL  L               +QE   E       LQ A+++ L  +++   A+ N   ++
Sbjct: 1301 ELDIL--------------PLQEANAELSEKSGMLQ-AEKKLLEEDVKRWKAR-NQHLVS 1344

Query: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3167
             +++ ++E+  + L E  +  K+ Q  ++  E+  +K         L++ + ++  LK +
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQ--QLTEEIGRLKAEIARSNASLTNNQNLIQSLKED 1402

Query: 3168 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE 3227
            L + + E ET         K+L+A  +++++K         T+   +K  R  +   E+ 
Sbjct: 1403 LNKVRTEKETI-------QKDLDAKIIDIQEKV-------KTITQVKKIGRRYKTQYEEL 1448

Query: 3228 KAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQK---IESQRMLY 3284
            KA+  +  E   +   D +    S ++        +++ K+ LN+++ K   +ESQ    
Sbjct: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQE--------MQELKETLNQAETKSKSLESQVENL 1500

Query: 3285 DAQLSEE--QGRNLELQ-VLLESEKVRIR-EMSSTLDRERELHAQL-QSSDGTGQSRPPL 3339
               LSE+  + RNL+ Q V L+SE  R+R ++     +E +L  Q+ +  + T ++    
Sbjct: 1501 QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA 1560

Query: 3340 PSE-----DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR--KTLQ 3392
             S+      +  +L K+ EE   R   L  + +K +LD   T  + + + ++ R  + L+
Sbjct: 1561 KSKIAHLAGVKDQLTKENEELKQRNGAL--DQQKDELDVRITALKSQYEGRISRLERELR 1618

Query: 3393 TEQEANTEGQKKMHELQSKVEDLQRQLEEK 3422
              QE + E + +  E  +KV + QRQ+  K
Sbjct: 1619 EHQERHLEQRDEPQEPSNKVPEQQRQITLK 1648



 Score =  157 bits (397), Expect = 2e-37
 Identities = 364/1781 (20%), Positives = 718/1781 (40%), Gaps = 292/1781 (16%)

Query: 694  QLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR-QEEKEKGTLEQEVQELQLKT 752
            Q +LE ++L  L +S+ N   + +  Q    Q EI+ L+ + EK K   EQ+  E++ + 
Sbjct: 6    QQVLERTELNKLPKSVQNKLEKFLADQ----QSEIDGLKGRHEKFKVESEQQYFEIEKRL 61

Query: 753  ELLEKQMKEKENDLQEKFAQLEAENSILK---DEKKTLEDMLKIHTPVSQEERLIFLDSI 809
               ++++  +  + Q    +LE  N+ LK   ++ K LE           ++R I + S 
Sbjct: 62   SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELE---------IAQDRNIAIQSQ 112

Query: 810  KSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYA 869
             +++K+ + E E   LI  NE L Q+   L E++++         K       ELQ    
Sbjct: 113  FTRTKEEL-EAEKRDLIRTNERLSQELEYLTEDVKRLNEKL----KESNTTKGELQ---- 163

Query: 870  CLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLE 929
              LK+ D+L+ S    ++  K + K L +E  L     T +        E KT   E L 
Sbjct: 164  --LKL-DELQAS----DVSVKYREKRLEQEKELLHSQNTWLNT------ELKTKTDELLA 210

Query: 930  MGEVVEKDTTELMEKLEVTKREKLELSQRLSDL--SEQLKQKHGEISFLNEEVKSLKQEK 987
            +G     +  EL   LE  K E   L ++++ L  S +  QKH E     + +  LK+ K
Sbjct: 211  LGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVE-----DLLTKLKEAK 265

Query: 988  EQVSLRCRELEIIIN-HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEES 1046
            EQ +    +    +N H +  N+       S      +T     A   + K+ K  GE +
Sbjct: 266  EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTR----AVEELHKLLKEAGEAN 321

Query: 1047 KIMVEDKVSFENMTVGEESKQEQLI---------LDHLPSVTK-------ESSLRATQPS 1090
            K + +  +  E      E +  + I          + L S TK       E  L A  P+
Sbjct: 322  KAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPT 381

Query: 1091 E---------NDKLQKELNVLKSEQNDLRLQ-MEAQRICLSLVYSTHVDQVREYMENEKD 1140
                        KL +  N     Q+ L L+ +E +RI      + ++D++ + +E  K 
Sbjct: 382  AAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI------NKYLDEIVKEVE-AKA 434

Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQ-------K 1193
              L   +EE   AQ+       K+ Q   +  + QE  D+      ++ +         K
Sbjct: 435  PILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVK 494

Query: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN-------EDPELQDYR 1246
             +S++    L  L    G +       EV++ D  +S + IS++       E+ + Q+ R
Sbjct: 495  DLSQQIRVLLMELEEARGNHVIRDE--EVSSADISSSSEVISQHLVSYRNIEELQQQNQR 552

Query: 1247 YEVQ-------DFQENMHTLLNKVTEEYNKL-----------------------LVLQTR 1276
              V          +E   T  +K+TE   KL                       +V Q  
Sbjct: 553  LLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRD 612

Query: 1277 LSKIWGQQTDGMKLEFGEENL--------PK-----------------EETEFLSIHSQM 1311
            + +I   QT G+ +     +L        PK                 E TE +   + +
Sbjct: 613  MYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL 672

Query: 1312 TNLEDIDVNHKSKLSS---LQDLEKTKLEEQVQELES----------LISSLQQQLKETE 1358
              L++I  N+K + +    +Q+ +  KL+EQV +L S            S   + L++  
Sbjct: 673  KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732

Query: 1359 QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG 1418
            + Y  EI  L +R Q ++ +T      ++++      A   +       +N+        
Sbjct: 733  EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL-------- 784

Query: 1419 EFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG--GKENTASSKQ 1476
                K+E  ++KL E +  +Q E  +A+      +     T L  I G   +  T + ++
Sbjct: 785  ----KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLL----TNLQTIQGILERSETETKQR 836

Query: 1477 AHAVCQQEQHYFNEMKLSQDQIGFQTF---ETVDVKFKEEFKPLSKELGEHGKEILLSNS 1533
              +  ++ +H  + +K   +    Q       +DV+  +  + L  E   H     L  +
Sbjct: 837  LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896

Query: 1534 DPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE 1593
               +I   K  +  +  ++ S+      +    ++  V   D   QL   EEQ+ D+++ 
Sbjct: 897  AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVD--DLVSQLRQTEEQVNDLKER 954

Query: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIK-----RLNRQLAQRSSIDNENL 1648
            L       +Q      QA +  +E     ++Q+ EE++     RL      ++ ++ + +
Sbjct: 955  LKTSTSNVEQ-----YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009

Query: 1649 VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
              E+E+   +EL+  K+ ++   E+   EL+ + +  QN      EV+E   +       
Sbjct: 1010 EVEKEK---QELQDDKRRAIESMEQQLSELKKTLSSVQN------EVQEALQRASTALSN 1060

Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEV--VKTTAAVEETIGRHVLGILDRSSKSQSS 1766
             +    +     + A++  N    +++L    V+   A +E + +        +S  Q  
Sbjct: 1061 EQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSK-------MASVRQHL 1113

Query: 1767 ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE-LSQRL 1825
                 ++E++        EE  R+  + +   S       D+   +++  +  E LS ++
Sbjct: 1114 EETTQKAESQLLECKASWEERERMLKDEV---SKCVCRCEDLEKQNRLLHDQIEKLSDKV 1170

Query: 1826 VRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQ 1885
            V S   G +  P N  L     S    + E++LE +     + E A+        ES R 
Sbjct: 1171 VASVKEGVQ-GPLNVSL-----SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRY 1224

Query: 1886 KQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFE--RQIQEKTD 1943
            +Q      +  +EL++ L+ E    +  A  +++ E ++        + E  + ++E+  
Sbjct: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEK- 1283

Query: 1944 IIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK 2003
              +RLEQ+L     ++++LE +   +QE    LS +   ++A     E++LL+E  K  K
Sbjct: 1284 --ERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQA-----EKKLLEEDVKRWK 1336

Query: 2004 EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQAL---EK 2060
             + +     +K  D   ++ + L  + E    R  +L +E      ++ + N +L   + 
Sbjct: 1337 ARNQHLVSQQK--DPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQN 1394

Query: 2061 QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKE 2120
             ++ +++ L++   ++E  +     +I  +++++K + + + I      + E+    LK 
Sbjct: 1395 LIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE----LKA 1450

Query: 2121 KTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVE 2180
            + DK  E   +  Q   D QE++  +++++    EL++  L  A+T  K           
Sbjct: 1451 QQDKVME---TSAQSSGDHQEQHVSVQEMQ----ELKET-LNQAETKSK----------- 1491

Query: 2181 AKPELSLEVQLQAERDAIDRKEKEITNLEEQ-------LEQFREELENKNEEVQQLHMQL 2233
                 SLE Q++  +  +  KE E  NL+EQ       L + R++L+++  + +QL  Q 
Sbjct: 1492 -----SLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ- 1545

Query: 2234 EIQKKESTTRLQELEQENKL-----FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ 2288
             I +KE  TR   +  ++K+      KD + K    +K+ +    Q +  L  +   +  
Sbjct: 1546 -ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKS 1604

Query: 2289 EKEVEIDQLNEQVTKLQQQLKITTD------NKVIEEKNEL 2323
            + E  I +L  ++ + Q++     D      NKV E++ ++
Sbjct: 1605 QYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQI 1645



 Score =  150 bits (379), Expect = 2e-35
 Identities = 340/1665 (20%), Positives = 678/1665 (40%), Gaps = 213/1665 (12%)

Query: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
            V  +++L+ L    + KLE+ + + +S I  L+ + ++ +   E +   ++KRL    E 
Sbjct: 8    VLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67

Query: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNI----DGTIEFSGEF-GVKEETNIVKLLE 1433
             V  +    S+ +        +   +   K +    D  I    +F   KEE    K   
Sbjct: 68   LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127

Query: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--AVCQQEQHYFNEM 1491
             +  E+L +E+  +   +     +  E +   G  +      QA   +V  +E+    E 
Sbjct: 128  IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187

Query: 1492 KLSQDQIGFQTFETVDVKFK-EEFKPLSKELG----------EHGKEIL---------LS 1531
            +L   Q    T+   ++K K +E   L +E G          E+ KE +         L 
Sbjct: 188  ELLHSQ---NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLK 244

Query: 1532 NSDPHDIPESKDCVLTI---SEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLE 1588
             S+ H     +D +  +    E+  S ++ F    + H ++S     A+        +L 
Sbjct: 245  TSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT 304

Query: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRLNRQLAQRSSIDNEN 1647
               +EL +  +E  +A + + Q H+ ++E+ ++  E ++ E+I RL ++L   + + +  
Sbjct: 305  RAVEELHKLLKEAGEANKAI-QDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS-- 361

Query: 1648 LVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN-ENQGEVEEQTFKEKELD 1706
              ++R+  +L E E       A       +     T+  N   E Q ++  +  + K ++
Sbjct: 362  -ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420

Query: 1707 RKPEDVPPE------ILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
            +  +++  E      IL  +R   ++A   +  +    VK   A++E     +  + + +
Sbjct: 421  KYLDEIVKEVEAKAPILKRQREEYERAQKAVASL---SVKLEQAMKE-----IQRLQEDT 472

Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820
             K+   +S++ R      ++     +  RV    +    G+ + R++    + ++     
Sbjct: 473  DKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEV 532

Query: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880
            +SQ LV            N E +   + RL  A+ +L E       +   +K+T+ +L  
Sbjct: 533  ISQHLV---------SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKL 583

Query: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI----DGYADEKTLFER 1936
            ES     E  +  K ++   + +    R R+   + LS+  GV         D+ +L   
Sbjct: 584  ES--ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641

Query: 1937 QIQEKT-DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL 1995
              +  T   +       +  S    E +A  +Q+QE  E   ++    KAE   ++ + L
Sbjct: 642  PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE----KAENEKIQNEQL 697

Query: 1996 QETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI--DVEEQVSRFIELEQEKNTELMDLRQ 2053
               EKL ++  +++ Q  K+   L    K  E+  D  E   R I    E+N +L    Q
Sbjct: 698  ---EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754

Query: 2054 -QNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVE 2112
             Q Q +    + +R   ++ A+      +V  + ++K ++ LK+          + R  +
Sbjct: 755  KQEQIINTMTQDLRGANEKLAV-----AEVRAENLKKEKEMLKL---------SEVRLSQ 800

Query: 2113 QLANHLKEKTDKCSELLLSKEQLQRDIQERNE---------EIEKLEFRVRELEQALLVS 2163
            Q  + L E+  +   LLL+  Q  + I ER+E         +IEKLE  +  L++ L   
Sbjct: 801  QRESLLAEQ--RGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENE 858

Query: 2164 ADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-RDAIDRKEKEITNLEEQLEQFREELENK 2222
             +    +        ++ K +L  E  L    ++ +   +KEI  L++ L     E++  
Sbjct: 859  VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM--EVQVA 916

Query: 2223 NEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA---IKESDAMSTQDQHVL 2279
            ++  Q+        K++    + +L Q  +   D  E+L  +   +++  AM T  +  L
Sbjct: 917  SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976

Query: 2280 FGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQE 2339
              K  Q+ +E    I+   ++  + Q QL+     +V +EK EL  D    IE +     
Sbjct: 977  -NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL-MEVEKEKQELQDDKRRAIESM----- 1029

Query: 2340 CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2399
                  E+++ +L + +  +Q E+    Q+ S    +LS E  + +   D     K+A+E
Sbjct: 1030 ------EQQLSELKKTLSSVQNEVQEALQRAST---ALSNEQQARR---DCQEQAKIAVE 1077

Query: 2400 QQVETANEEMTFMKNV-----LKETNFKMNQLTQELFSLKRERES-VEKIQSIPENSVNV 2453
             Q +   E M    +V      KE   KM  + Q L    ++ ES + + ++  E    +
Sbjct: 1078 AQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137

Query: 2454 AIDHLSK-----DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTV 2508
              D +SK     +  E +  L  D ++ L ++    S +E  +G  +N+    L  E   
Sbjct: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV-VASVKEGVQGP-LNVS---LSEEGKS 1192

Query: 2509 SAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV 2564
              + LE+ +  ++ K++ E      Q E+   ++++  L++ ++E   +      + E V
Sbjct: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSL---NAEREKV 1249

Query: 2565 QEYAKFCQDNQTISSEPERTNI--QNLNQLREDE--LGSDISALTLRISELESQVVEMHT 2620
            Q  AK    ++ +  + E  N+  +    LRE++  L  D+  +  ++ +LE  +     
Sbjct: 1250 QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI----- 1304

Query: 2621 SLILEKEQVEIAEKN-VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTEL- 2678
             L L++   E++EK+ +L+ EKKLLE + +     + Q    +++ P   E  K  +E  
Sbjct: 1305 -LPLQEANAELSEKSGMLQAEKKLLE-EDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKE 1362

Query: 2679 FHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDL----- 2733
             H+        E+  L+AE   + A L + +   + L+E+L    T   ++QKDL     
Sbjct: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422

Query: 2734 ---------SQVR-----------------DHLAEAKEKLSILEKEDETEVQESKKACMF 2767
                     +QV+                 D + E   + S   +E    VQE ++    
Sbjct: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482

Query: 2768 EPLPIKLSKSIASQTDGTLKISS---------SNQTPQILVKNAGIQINLQSECSSEEVT 2818
                   SKS+ SQ +   K  S           QT Q+  + + ++ +LQ   + EE  
Sbjct: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEE-- 1540

Query: 2819 EIISQFTEKIEKMQEL------HAAEILDMESRHISETETLKREH 2857
            ++  Q TEK EK ++         A +  ++ +   E E LK+ +
Sbjct: 1541 QLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRN 1585



 Score =  149 bits (377), Expect = 4e-35
 Identities = 375/1821 (20%), Positives = 748/1821 (41%), Gaps = 313/1821 (17%)

Query: 554  QESKLNEAHKSLST-----VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN 608
            + ++LN+  KS+       + D ++EI    + R E + K E+E   ++I+  +   ++ 
Sbjct: 10   ERTELNKLPKSVQNKLEKFLADQQSEI-DGLKGRHE-KFKVESEQQYFEIEKRLSHSQER 67

Query: 609  AVLD-RMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQI 667
             V + R  +S   ELE+L  QL     + L++  ++LEI    NI               
Sbjct: 68   LVNETRECQSLRLELEKLNNQL-----KALTEKNKELEIAQDRNI--------------- 107

Query: 668  DGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL----KDLQQSLVNSKSE--EMTLQI 721
              +Q++ ++  E ++ EK +LI    +L  E+  L    K L + L  S +   E+ L++
Sbjct: 108  -AIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKL 166

Query: 722  NELQKEIEILRQEEKEKGTLEQEVQ-----------ELQLKTELLEKQMKEKENDLQEKF 770
            +ELQ     ++  EK    LEQE +           EL+ KT+ L    +EK N++ E  
Sbjct: 167  DELQASDVSVKYREKR---LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELK 223

Query: 771  AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830
              LE +    K+E   LE+ +                    K+ +   +K +E L+ + +
Sbjct: 224  CNLENK----KEEVSRLEEQMN-----------------GLKTSNEHLQKHVEDLLTKLK 262

Query: 831  DLKQQCIQLNEEIE-------KQRNTFSFAEKNFEVNYQELQ---EEYACLLK------- 873
            + K+Q   + E+         K  N +  A  + E    EL    EE   LLK       
Sbjct: 263  EAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK 322

Query: 874  -VKDDL---EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLE 929
             ++D L   E SK++ E E   K+  L +EL       +  K K ++  E++  +A    
Sbjct: 323  AIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEE--LAAMSP 380

Query: 930  MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989
                V K     M KL       +E   +L  L E+L+ K     +L+E VK + + K  
Sbjct: 381  TAAAVAKIVKPGM-KLTELYNAYVETQDQL--LLEKLENKRIN-KYLDEIVKEV-EAKAP 435

Query: 990  VSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM 1049
            +  R RE          E  Q     +S  L+  +    R  E +  K NK    +S ++
Sbjct: 436  ILKRQRE--------EYERAQKAVASLSVKLEQAMKEIQRLQEDT-DKANK----QSSVL 482

Query: 1050 VEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV---LKSEQ 1106
              D    E + V + S+Q +++L  L        +R  + S  D       +   L S +
Sbjct: 483  ERDNRRME-IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR 541

Query: 1107 NDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI-- 1164
            N   LQ + QR+ ++L       ++ E  E E+ +   S   EL    E  + EL+++  
Sbjct: 542  NIEELQQQNQRLLVAL------RELGETREREEQETTSSKITELQLKLESALTELEQLRK 595

Query: 1165 ---HQLEL-----------QTMKTQETGDEGKPLHLL-IGKLQKAVSEECSYFLQTLCSV 1209
               HQ++L           + + +Q TG    PLH   +  +  A + +     QT+   
Sbjct: 596  SRQHQMQLVDSIVRQRDMYRILLSQTTG-VAIPLHASSLDDVSLASTPKRPSTSQTVS-- 652

Query: 1210 LGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNK 1269
                 TPA    + + +   +   + + ++   ++Y+ E  + ++  +  L K+ E+   
Sbjct: 653  -----TPAPVPVIESTEAIEAKAALKQLQEI-FENYKKEKAENEKIQNEQLEKLQEQVTD 706

Query: 1270 LLVLQTRLSKIWGQQTD--GMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSS 1327
            L    T++S     Q D    + E  ++N+     E  S+H +   L       +  +++
Sbjct: 707  LRSQNTKIST----QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT 762

Query: 1328 L-QDL--------------EKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL 1372
            + QDL              E  K E+++ +L  +  S Q++    EQ  +  +    + +
Sbjct: 763  MTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTI 822

Query: 1373 QAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIE-------------FSGE 1419
            Q + E +       ++     S  ++  +  S +KK ++  +E                +
Sbjct: 823  QGILERS-----ETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877

Query: 1420 FGVKEETNIVKLLEKQYQEQLEEEVAKV---IVSMSIAFAQQTELSRISGGKENTASSKQ 1476
              +  ETN+  L  K+  +  ++E+A +   + +M +  A Q+      G   N      
Sbjct: 878  RQLDTETNL-HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDD 936

Query: 1477 AHAVCQQEQHYFNEMK--LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSD 1534
              +  +Q +   N++K  L       + ++ +    +E      +   E  K I +    
Sbjct: 937  LVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR--- 993

Query: 1535 PHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL 1594
               + ES +    + +++   +K    +Q + D       D  R +   E+QL ++++ L
Sbjct: 994  ---LKESAEFQTQLEKKLMEVEKE---KQELQD-------DKRRAIESMEQQLSELKKTL 1040

Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERER 1654
                 E Q+A +    A   + + +R+ QEQ +  ++  N+               ERE 
Sbjct: 1041 SSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKY--------------EREL 1086

Query: 1655 VL-LEELEALKQLSLAGREKL--CCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPED 1711
            +L   ++EAL+    A +E++     +R    +T    E+Q    + +++E+E   K ++
Sbjct: 1087 MLHAADVEALQ----AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK-DE 1141

Query: 1712 VPPEILSNERYALQKANNRLLKILLEVV--KTTAAVEETIGRHVLGILDRSSKSQSSASL 1769
            V   +   E    Q   NRLL   +E +  K  A+V+E +   +   L    KSQ     
Sbjct: 1142 VSKCVCRCEDLEKQ---NRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILE 1198

Query: 1770 IW---RSEAE--------ASVKSCVHEEHTRVTDESIPSYSGS-DMPRNDINMWSKVTEE 1817
            I    R E E        A V+S  + +   + +  +     S +  R  + + +K   +
Sbjct: 1199 ILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQ 1258

Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
              EL ++             E   +++  +  L+   E+L     E   Q   AKV + E
Sbjct: 1259 HEELMKK------------TETMNVVMETNKMLREEKERL-----EQDLQQMQAKVRKLE 1301

Query: 1878 L----MRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVID--GYADEK 1931
            L    ++E+  +  E +  L+ +++L E   +  +AR Q  V   K     +      EK
Sbjct: 1302 LDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEK 1361

Query: 1932 TLFERQIQEKTDIIDRLEQELLCAS-------NRLQELEAEQQQIQEERELLSRQKEAMK 1984
             +  ++IQ+ T+ I RL+ E+  ++       N +Q L+ +  +++ E+E + +  +A  
Sbjct: 1362 EVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKI 1421

Query: 1985 AEAGPVEQQLLQETE-KLMKEKLEVQCQAEKVRDDLQKQVKALEI-DVEEQVSRFIELEQ 2042
             +   +++++   T+ K +  + + Q +  K + D   +  A    D +EQ     E+++
Sbjct: 1422 ID---IQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQE 1478

Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102
             K T L     ++++LE Q+E ++K L E    +E E    Q++  +L+ +L    R + 
Sbjct: 1479 LKET-LNQAETKSKSLESQVENLQKTLSE----KETEARNLQEQTVQLQSELS---RLRQ 1530

Query: 2103 ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162
              + +T + EQL   + EK +K  + +++ +     +    +++ K              
Sbjct: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTK-------------- 1576

Query: 2163 SADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENK 2222
                 +  E ++  GA++ + +  L+V++ A +    + E  I+ LE +L + +E    +
Sbjct: 1577 -----ENEELKQRNGALDQQKD-ELDVRITALK---SQYEGRISRLERELREHQERHLEQ 1627

Query: 2223 NEEVQQLHMQLEIQKKESTTR 2243
             +E Q+   ++  Q+++ T +
Sbjct: 1628 RDEPQEPSNKVPEQQRQITLK 1648



 Score =  140 bits (353), Expect = 2e-32
 Identities = 344/1771 (19%), Positives = 707/1771 (39%), Gaps = 293/1771 (16%)

Query: 1509 KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCV-LTISEEMFSKDKTFIVRQSIHD 1567
            KFK E +    E+     E  LS+S    + E+++C  L +  E  +     +  ++   
Sbjct: 45   KFKVESEQQYFEI-----EKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL 99

Query: 1568 EISVS-SMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQL 1626
            EI+   ++    Q    +E+LE  +++L+                  R  ER  ++ E L
Sbjct: 100  EIAQDRNIAIQSQFTRTKEELEAEKRDLI------------------RTNERLSQELEYL 141

Query: 1627 QEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQ 1686
             E++KRLN +L + ++   E       ++ L+EL+A   +S+  REK   E       +Q
Sbjct: 142  TEDVKRLNEKLKESNTTKGE------LQLKLDELQA-SDVSVKYREKR-LEQEKELLHSQ 193

Query: 1687 NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVE 1746
            N   N  E++ +T +   L R+  +   E+  N     ++ +   L+  +  +KT+    
Sbjct: 194  NTWLNT-ELKTKTDELLALGREKGNEILELKCNLENKKEEVSR--LEEQMNGLKTS---N 247

Query: 1747 ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE---HTRVTDESIPSYSGSDM 1803
            E + +HV  +L +  +++         E +AS++   H E   H ++++    +   S+ 
Sbjct: 248  EHLQKHVEDLLTKLKEAK---------EQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298

Query: 1804 PRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863
              N++      T    EL + L  +G A   I    ++ +L +        +++LE I  
Sbjct: 299  KSNEL------TRAVEELHKLLKEAGEANKAI----QDHLLEVEQSKDQMEKEMLEKIGR 348

Query: 1864 TSSQLEHAKVTQTELMRESFRQKQE-----------ATESLKCQEELRERLHEESRAREQ 1912
               +LE+A    +   R+     +E             + +K   +L E  +     ++Q
Sbjct: 349  LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408

Query: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE 1972
            L +E  + +  I+ Y DE     ++++ K  I+ R  +E   A   +  L  + +Q  +E
Sbjct: 409  LLLEKLENKR-INKYLDE---IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKE 464

Query: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032
             + L    +    ++  +E+            ++E+Q +      DL +Q++ L +++EE
Sbjct: 465  IQRLQEDTDKANKQSSVLERD---------NRRMEIQVK------DLSQQIRVLLMELEE 509

Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092
                 +  ++E ++   D+   ++ + + L   R                  +E+Q+  Q
Sbjct: 510  ARGNHVIRDEEVSS--ADISSSSEVISQHLVSYRNI----------------EELQQQNQ 551

Query: 2093 QLKVVPRFQPISEHQTR-EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151
            +L V  R   + E + R E E  ++ + E   K    L   EQL++  Q + + ++ +  
Sbjct: 552  RLLVALR--ELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSI-V 608

Query: 2152 RVRELEQALL-----VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE---- 2202
            R R++ + LL     V+        D     +   +P  S  V   A    I+  E    
Sbjct: 609  RQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEA 668

Query: 2203 -KEITNLEEQLEQF-REELEN---KNEEVQQLHMQ---LEIQKKESTTRLQELEQENKLF 2254
               +  L+E  E + +E+ EN   +NE++++L  Q   L  Q  + +T+L    +  ++ 
Sbjct: 669  KAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEML 728

Query: 2255 KDDMEKLGLAI------KESDAMSTQDQHVLFGKFAQIIQ---EKEVEIDQLNEQVTKLQ 2305
            +D++E     I       +    +TQ Q  +     Q ++   EK    +   E + K +
Sbjct: 729  QDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788

Query: 2306 QQLKITTDNKVIEEKNELIRDLETQ---IECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362
            + LK+ ++ ++ +++  L+ +   Q   +  L + Q  ++R+  E  ++L+  IEKL+ E
Sbjct: 789  EMLKL-SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE 847

Query: 2363 LANIGQKTSMNA---HSLSEEAD----SLKHQLDVVIAEKLALEQQVETANEEMTFMK-- 2413
            ++++ +K        H+L+   D      K QLD      L  ++ ++ A +E+  +K  
Sbjct: 848  ISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH 907

Query: 2414 -------------------------------NVLKETNFKMNQLTQELFSLKRERESVEK 2442
                                           + L++T  ++N L + L +     E  + 
Sbjct: 908  LSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQA 967

Query: 2443 IQSIPENSVNVAIDHLSKDKPELEVVLTEDA-------LKSLENQTYFKSFEENGKGSII 2495
            + +  E S+N       + +  +EV L E A        K +E +   +  +++ + +I 
Sbjct: 968  MVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIE 1027

Query: 2496 NLETRLLQLESTVSAKDLELTQCYKQIK---DMQEQGQFETEMLQKKIVNLQKIVEEKVA 2552
            ++E +L +L+ T+S+   E+ +  ++       ++Q + + +   K  V  Q   E ++ 
Sbjct: 1028 SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELM 1087

Query: 2553 --AALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLN-----QLREDELGSDISALT 2605
              AA V  +Q  A ++ +K     Q +    ++   Q L      + RE  L  ++S   
Sbjct: 1088 LHAADVEALQ-AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV 1146

Query: 2606 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2665
             R  +LE Q   +H  +    ++V  + K   E  +  L +    EG  ++Q  +  +  
Sbjct: 1147 CRCEDLEKQNRLLHDQIEKLSDKVVASVK---EGVQGPLNVSLSEEGKSQEQILEILRFI 1203

Query: 2666 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE-----KLQEELL 2720
             ++ E+ +T  E+    E   +   +E L  E    +  L + +EK +       Q E L
Sbjct: 1204 RREKEIAETRFEVAQV-ESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEEL 1262

Query: 2721 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIAS 2780
            +K+T   ++  + +++   L E KE+L    ++D  ++Q   +    + LP++ + +  S
Sbjct: 1263 MKKTETMNVVMETNKM---LREEKERL----EQDLQQMQAKVRKLELDILPLQEANAELS 1315

Query: 2781 QTDGTLKISSSNQTPQILVKNAGIQ--INLQSECSSEEVTEIISQFTEKIEKMQELHAAE 2838
            +  G L+         +    A  Q  ++ Q +  +EE  +++S+               
Sbjct: 1316 EKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSE--------------- 1360

Query: 2839 ILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT- 2897
                           K  H   +Q L EE G LKA              E+A S+A  T 
Sbjct: 1361 ---------------KEVHTKRIQQLTEEIGRLKA--------------EIARSNASLTN 1391

Query: 2898 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNE-GMQ 2956
             +        D  +      +   D+ ++    + +  T +  KKI    +  + E   Q
Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451

Query: 2957 VLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI----SSLKDLITKMQLQREAEVYDS 3012
               + E+      DH  Q VS   ++E K  +N       SL+  +  +Q     +  ++
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511

Query: 3013 SQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQG 3072
                E     + EL    Q   L++R+      R ++T         ++    +     G
Sbjct: 1512 RNLQEQTVQLQSELSRLRQD--LQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAG 1569

Query: 3073 VEYQAAMECLQKADRRSLLSE--------IQALHAQMNGRKITLKREQESEKPSQELLEY 3124
            V+ Q   E  +   R   L +        I AL +Q  GR   L+RE             
Sbjct: 1570 VKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERE------------- 1616

Query: 3125 NIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
             +++ Q + LE + E     ++  E Q Q++
Sbjct: 1617 -LREHQERHLEQRDEPQEPSNKVPEQQRQIT 1646



 Score =  135 bits (340), Expect = 8e-31
 Identities = 212/1010 (20%), Positives = 425/1010 (42%), Gaps = 145/1010 (14%)

Query: 135  REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQ 194
            R ++        EQ        L     +LA  +   E L +E E ++++     ++  Q
Sbjct: 745  RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSE----VRLSQ 800

Query: 195  EFEAAIKQRDGIITQLTANLQ--QARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETL 251
            + E+ + ++ G    LT NLQ  Q   E+ ET  +   L+ Q +KL+ +   L+   E  
Sbjct: 801  QRESLLAEQRGQNLLLT-NLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858

Query: 252  RNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVY 308
                H+ T      LL  K+Q+ T          LL++ QK+       +S ++ ++   
Sbjct: 859  VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918

Query: 309  EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQ 368
              ++  K + SNKE+       +++L +++ + E++  +LK++L T+   + + Q  +  
Sbjct: 919  SSQRTGKGQPSNKED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT- 970

Query: 369  KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR 428
                       L  S  KE+Q +EE++      + ++ R  + ++F+T + +++      
Sbjct: 971  ----------SLEESLNKEKQVTEEVR------KNIEVRLKESAEFQTQLEKKL-----M 1009

Query: 429  KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI 488
            ++E+ + EL +   + I  M+Q+L     +++++  +  + E++ AL+  S    NE Q 
Sbjct: 1010 EVEKEKQELQDDKRRAIESMEQQL-----SELKKTLSSVQNEVQEALQRASTALSNEQQA 1064

Query: 489  KLMNVAINELNIKLQDTNSQKEKLK------EELGLILEEKCALQRQLEDLVEELSFSRE 542
            +       +  I ++  N  + +L       E L    E+   +    + L E    +  
Sbjct: 1065 R--RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122

Query: 543  QIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
            Q+   + +  E+E  L +E  K +   EDL+ +     +  ++L  K  A V       E
Sbjct: 1123 QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVK------E 1176

Query: 602  MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
             ++   N  L    +SQE  LE LR       E+E++        E R  + +++    +
Sbjct: 1177 GVQGPLNVSLSEEGKSQEQILEILR---FIRREKEIA--------ETRFEVAQVE---SL 1222

Query: 662  HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI 721
             Y+Q+++ L+ E+ +  +++  E++          ++++     Q   +  K+E M + +
Sbjct: 1223 RYRQRVELLERELQELQDSLNAEREK---------VQVTAKTMAQHEELMKKTETMNVVM 1273

Query: 722  NELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781
                 E   + +EEKE+  LEQ++Q++Q K   LE  +      LQE  A+L  ++ +L+
Sbjct: 1274 -----ETNKMLREEKER--LEQDLQQMQAKVRKLELDIL----PLQEANAELSEKSGMLQ 1322

Query: 782  DEKKTLEDMLKIHTP-----VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK--- 833
             EKK LE+ +K         VSQ++     +  K  S+  V  K I+ L EE   LK   
Sbjct: 1323 AEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382

Query: 834  ----------QQCIQ-LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882
                      Q  IQ L E++ K R      +K+ +    ++QE+   + +VK      K
Sbjct: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442

Query: 883  NKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942
             + E     +LKA  +++       +    +  V  ++   + ETL   E   K     +
Sbjct: 1443 TQYE-----ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV 1497

Query: 943  EKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE---- 998
            E L+ T  EK        +L EQ  Q   E+S L ++++    ++EQ+  +  E E    
Sbjct: 1498 ENLQKTLSEK---ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554

Query: 999  --IIINHNRAENVQSCDTQVS-----------------SLLDGVVTMTSRGAEGSVSKVN 1039
              I+   ++  ++     Q++                   LD  +T      EG +S++ 
Sbjct: 1555 KAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLE 1614

Query: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089
            +   E  +  +E +   +  +     +Q Q+ L   P+  +      + P
Sbjct: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDP 1664



 Score =  129 bits (324), Expect = 6e-29
 Identities = 314/1499 (20%), Positives = 619/1499 (41%), Gaps = 195/1499 (13%)

Query: 2304 LQQQLKITTDNKV---IEEKNE-LIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2359
            LQQ L+ T  NK+   ++ K E  + D +++I+ L    E  K   E++  ++ + +   
Sbjct: 5    LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64

Query: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQL----------DVVIAEKLALEQQVETANEEM 2409
            Q+ L N     +    SL  E + L +QL          ++     +A++ Q     EE+
Sbjct: 65   QERLVN----ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120

Query: 2410 TFMKNVLKETNFKMNQLTQELFSLKRERESVEKI-QSIPENSVNVAIDHLSKDKPELEVV 2468
               K  L  TN    +L+QEL  L    E V+++ + + E++       L  D+ +   V
Sbjct: 121  EAEKRDLIRTN---ERLSQELEYLT---EDVKRLNEKLKESNTTKGELQLKLDELQASDV 174

Query: 2469 LTEDALKSLENQTYFKSFEENGKGSIINLET-RLLQLESTVSAKDLELTQCYKQIKDMQE 2527
              +   K LE +      +     + +  +T  LL L      + LEL +C  + K  +E
Sbjct: 175  SVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILEL-KCNLENKK-EE 232

Query: 2528 QGQFETEMLQKKIVN--LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTN 2585
              + E +M   K  N  LQK VE+ +     ++ Q  +++E  KF  +            
Sbjct: 233  VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE--KFHNELNA------HIK 284

Query: 2586 IQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2645
            + NL +   D+  +       + +EL   V E+H  L    E  +  + ++LE E+   +
Sbjct: 285  LSNLYKSAADDSEA-------KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337

Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL 2705
            ++K  E  EK  R +++  +  D+           S EE    +   A  A+ V    +L
Sbjct: 338  MEK--EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL 395

Query: 2706 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2765
                    + Q++LL+++     + K L ++   + E + K  IL+++ E E + ++KA 
Sbjct: 396  TELYNAYVETQDQLLLEKLENKRINKYLDEI---VKEVEAKAPILKRQRE-EYERAQKAV 451

Query: 2766 MFEPLPIKLSKS------IASQTDGTLKISS----SNQTPQILVKNAGIQIN-LQSECSS 2814
                L +KL ++      +   TD   K SS     N+  +I VK+   QI  L  E   
Sbjct: 452  A--SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509

Query: 2815 EEVTEIISQFTEKIEKMQELHAAEILD---MESRHISETETLKREHYVAVQLL-----KE 2866
                 +I    E++       ++E++    +  R+I E +   +   VA++ L     +E
Sbjct: 510  ARGNHVIRD--EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRERE 567

Query: 2867 ECGTLKAVIQCLRSKEGSSIPELAH---SDAYQTREICSSDSGSDWGQGIYLTHSQGFDI 2923
            E  T  + I  L+ K  S++ EL     S  +Q + + S     D  + I L+ + G  I
Sbjct: 568  EQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYR-ILLSQTTGVAI 626

Query: 2924 ASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEE 2983
                   +  S   S PK+            + V+  TE+  +      +Q++ E + +E
Sbjct: 627  PLHASSLDDVSLA-STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE 685

Query: 2984 RKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLA 3043
            +           + I   QL++  E     +S  +         ++ Q  F  +R  +L 
Sbjct: 686  KAE--------NEKIQNEQLEKLQEQVTDLRSQNT--------KISTQLDFASKRYEMLQ 729

Query: 3044 ----AFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA 3099
                 +R E+T+L   +       L    Q+Q        + L+ A+ +  ++E++A + 
Sbjct: 730  DNVEGYRREITSLHERNQK-----LTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784

Query: 3100 QMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA-TELQEQLSSEK 3158
            +     + L   + S++    L E   Q+ Q+ +L     +  + +R+ TE +++LSS+ 
Sbjct: 785  KKEKEMLKLSEVRLSQQRESLLAE---QRGQNLLLTNLQTIQGILERSETETKQRLSSQ- 840

Query: 3159 MVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD---EVHL-LNDTLASEQ 3214
              + +L+ E++  K +LE  ++ +H   + L+   L+ K + D    +HL   + L + Q
Sbjct: 841  --IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQ 898

Query: 3215 KKSRELQWALEKEKAKL--------GRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3266
            K+   L+  L   + ++        G+ +  +KE+++DL   L   +++   L   L+  
Sbjct: 899  KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTS 958

Query: 3267 KQLLNESQQKIES--QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHA 3324
               + + Q  + S  + +  + Q++EE  +N+E++ L ES + + +     ++ E+E   
Sbjct: 959  TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR-LKESAEFQTQLEKKLMEVEKEKQ- 1016

Query: 3325 QLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDR 3384
            +LQ                 ++ +++QL E    +  + NE +    ++LQ       + 
Sbjct: 1017 ELQDD-----------KRRAIESMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNE 1061

Query: 3385 QVHRKTLQTEQEANTEGQKKMH-ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF 3443
            Q  R+  Q + +   E Q K   EL     D++  L+  ++QV K+    Q L+   Q+ 
Sbjct: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEA-LQAAKEQVSKMASVRQHLEETTQKA 1120

Query: 3444 QKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE-------GETKESNYA 3496
            + Q LE +   E R  + ++              +N +L  +IE          KE    
Sbjct: 1121 ESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQG 1180

Query: 3497 KL-IEMNGGGTGCNHELEM---IRQKLQCVASKLQVLP------QKASERLQFETADDED 3546
             L + ++  G      LE+   IR++ +   ++ +V        ++  E L+ E  + +D
Sbjct: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240

Query: 3547 FIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAE------------ 3594
             +    N +   +Q+   T  Q EE    + + +    T ++LR+  E            
Sbjct: 1241 SL----NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAK 1296

Query: 3595 ----------LTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANI 3644
                      L    ++L+E+   L+     LEE ++ ++       N    S     + 
Sbjct: 1297 VRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR-----NQHLVSQQKDPDT 1351

Query: 3645 EAI--IASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL-RNDSLLQTLSPDSEHVTLKR 3700
            E    + SEKEV  +    L + + R +AE+ +  A L  N +L+Q+L  D   V  ++
Sbjct: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEK 1410


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score =  179 bits (453), Expect = 6e-44
 Identities = 350/1771 (19%), Positives = 727/1771 (41%), Gaps = 190/1771 (10%)

Query: 6    RQKKLEAGKAKLAQFRQR----KAQSDGQSPSKKQKKKRKTSSSK------HDVSAHHDL 55
            +QK++E    K  Q   +    K QS  QS          T+SS       H  SA HD 
Sbjct: 101  QQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDD 160

Query: 56   NID-------QSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEIS 108
            ++D       Q + N +  N   R+ES V     I +T  +    + +Q    +L++ I 
Sbjct: 161  DMDFGDIISSQQEINRLS-NEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIK 219

Query: 109  TTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELA-GK 167
                + S E++     M   +  N  +++   +   + E+   D    +E +E+ L  G 
Sbjct: 220  ELKQNRSQEIDDHQHEMSVLQ--NAHQQKLTEISRRHREE-LSDYEERIEELENLLQQGG 276

Query: 168  QHEIEELNRELEEMRVTYGT------EGLQQLQEFEAAIKQRDGIITQLTANLQQARREK 221
               IE    ++ EM+ T         E  +++++ E  IK  +  ++    +    RRE+
Sbjct: 277  SGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQ 336

Query: 222  DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK--QQILTHQQQLEE 279
            ++   E  ++ E+ + L+++  +LQ S   ++ T +     L Q+   +++   QQ L +
Sbjct: 337  EQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSD 396

Query: 280  QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ--------EKETII 331
             ++ +       +D ++    L+ K+++  +E++K + +  KEE+Q        E E I 
Sbjct: 397  AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK 456

Query: 332  E----------ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381
                       EL+   +  E K  EL   ++  + L+ E++E   Q  +  K+M L   
Sbjct: 457  STATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKD 516

Query: 382  NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
               +++ +    I +L   + + +KR H+    + DI + ++ + + KL Q    L++++
Sbjct: 517  QLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKE-KLIQSEVALNDLH 575

Query: 442  GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNI 500
              +  Q  ++ +   + Q+ + +  +    +  L    +I  NE+++ ++ N  +  LN 
Sbjct: 576  LTK--QKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLN- 632

Query: 501  KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
              QD+NS     K+ L   L+E+ A  R L+  + EL    E +++    +  +  KL  
Sbjct: 633  --QDSNSN---FKDTL---LKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL-- 682

Query: 561  AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE----KNAVLDRMAE 616
                +   ED++ ++        +L L+    V   K++   +E E    K  +L+  A 
Sbjct: 683  ----VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEE-AN 737

Query: 617  SQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ 676
              E  +E L      S+   L+     LE EH I + + KD      K+ I+ +  +  +
Sbjct: 738  KYEKTIEEL------SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE 791

Query: 677  KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK 736
              + +     + + +Q QL   I+K +   + L   K     LQ  EL K  + LR+ E 
Sbjct: 792  TKDVLS----SSLEEQKQLTQLINKKEIFIEKL---KERSSKLQ-EELDKYSQALRKNEI 843

Query: 737  EKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIH 794
             + T+E++ + L          MKE+ N LQE+  +L  E S      + KTL+ + ++ 
Sbjct: 844  LRQTIEEKDRSLG--------SMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELA 895

Query: 795  TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
            + VSQ      L++IK   ++ +  K  + +IE+    K Q +Q  +E +K+ + F +  
Sbjct: 896  SEVSQ------LNTIKEHLEEEI--KHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQH 947

Query: 855  KNFEVNYQEL----QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTV 910
            +     + +L     EE   L K  + ++   +++  + ++    + +E  +Q +N    
Sbjct: 948  EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENG 1007

Query: 911  KMKSSVFDED-----KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ 965
              K  +   +     K      LE+  + EK+ +   +  +++K E  +L+Q +     +
Sbjct: 1008 SEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLE 1067

Query: 966  LKQKHGEISFLN--EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGV 1023
            ++  H  IS  +  ++V  L+Q+ +  ++   ++  ++N    EN     T+   ++D V
Sbjct: 1068 IQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN-SHLKTEYHKMMDIV 1126

Query: 1024 VTMTSR--GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE-------SKQEQLILDH 1074
                +     +    K++  F    + M  + +   +  + E+       S++ Q +L  
Sbjct: 1127 AAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAV 1186

Query: 1075 LPSVTKESSLRATQPSENDKLQKELNVLKSE--------QNDLRLQMEAQRICLSLVYST 1126
            L + +  +       ++ ++L +E + LK +        Q  +      Q     L    
Sbjct: 1187 LQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL 1246

Query: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
            H  Q +  ++++ +  L      LI + E+   +L+   Q   Q   +   G       L
Sbjct: 1247 HQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHS--IGQLCNTKDL 1304

Query: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
            L+GKL     +  S  L T  S        A K EV +E  E     + E     LQ+  
Sbjct: 1305 LLGKLDIISPQLSSASLLTPQSA---ECLRASKSEVLSESSELLQQELEELRK-SLQEKD 1360

Query: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-----ENLPKEE 1301
              ++  QEN H L + +           + L +   +QTD    +  E     + L KE+
Sbjct: 1361 ATIRTLQENNHRLSDSIAAT--------SELERKEHEQTDSEIKQLKEKQDVLQKLLKEK 1412

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
               +   S      + +  +K   + L     T L+E++  LE  I  L+ + ++  + Y
Sbjct: 1413 DLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY 1472

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPV-DSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEF 1420
              +    +   QA+ E+ +  S+ + +      S  ++ +     +K+   G    +GE 
Sbjct: 1473 RGK----ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGK---TGE- 1524

Query: 1421 GVKEETNIVKLLEKQ---YQEQLEEEVAKVIVSMSIAFAQQTELSRISGG--KENTASSK 1475
             + +  N VK ++++   +Q++ ++ +  +        A Q E+ R+     + N    +
Sbjct: 1525 -LNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELER 1583

Query: 1476 QAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDP 1535
              + + + E  Y  E   ++D+         + K +++   L ++L      +  SN+  
Sbjct: 1584 LRNHLLESEDSYTREALAAEDR---------EAKLRKKVTVLEEKL------VSSSNAME 1628

Query: 1536 HDIPESKDCVLTISEEMF----SKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMR 1591
            +   ++   V ++ E++      +D+T +      +++   ++  +   M+    LE  +
Sbjct: 1629 NASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMV----LEHFQ 1684

Query: 1592 QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSE 1651
            QE    Y    +  + L     +  E        LQE +   N  L   S +  +  V E
Sbjct: 1685 QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKE 1744

Query: 1652 RERVLLEELEALKQLSLAGREKLCCELRNSS 1682
             +   L+    L+Q  L   +K    L NSS
Sbjct: 1745 EQIEELKRQNELRQEMLDDVQKKLMSLANSS 1775



 Score =  170 bits (431), Expect = 2e-41
 Identities = 362/1744 (20%), Positives = 735/1744 (42%), Gaps = 269/1744 (15%)

Query: 1832 GTEIDPENEELML-NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEAT 1890
            GT+   ++E   L NI   L+    + ++      S L++A   Q +L   S R ++E +
Sbjct: 202  GTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAH--QQKLTEISRRHREELS 259

Query: 1891 ESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ 1950
            +  +  EEL   L +       +  +LSK       Y  +KT+   QI EK +   ++EQ
Sbjct: 260  DYEERIEELENLLQQGGSG--VIETDLSKI------YEMQKTIQVLQI-EKVESTKKMEQ 310

Query: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010
                  ++++++  +    + +R++L R++E +  E    ++Q+++E E L  E  ++Q 
Sbjct: 311  ----LEDKIKDINKKLSSAENDRDILRREQEQLNVE----KRQIMEECENLKLECSKLQP 362

Query: 2011 QAEKVRDDLQKQVKALEIDVE-EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
             A K  D + ++ + L      E+V R  +   +   E+M L   NQ      + ++  +
Sbjct: 363  SAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM 422

Query: 2070 DEQAIDREHERDVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2128
              + +++E  + +  QE ++L+  L K+   ++ I    TR++              SEL
Sbjct: 423  RIEVLEKE--KSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISL-----------DSEL 469

Query: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLE 2188
               +  L+   QE N+ I + E  + E+E+         Q  E  KH   +  K +LS +
Sbjct: 470  HDLRLNLEAKEQELNQSISEKETLIAEIEEL------DRQNQEATKHM--ILIKDQLSKQ 521

Query: 2189 VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK---ESTTRLQ 2245
               Q E D+I      I+ L++ L   ++ +    ++   +  +L++QK+   +S   L 
Sbjct: 522  ---QNEGDSI------ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALN 572

Query: 2246 ELEQENKLFKDDMEKLGLAIKESDA--MSTQDQHVLFGKFAQIIQEKEVEIDQL-NEQVT 2302
            +L    +  +D +E L   + +S    +S Q +++   +  + I++ E E+ ++ NE + 
Sbjct: 573  DLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENL---ELKEHIRQNEEELSRIRNELMQ 629

Query: 2303 KLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362
             L Q       + +++E+   +R+L+  +                E+EQLNE ++K+  +
Sbjct: 630  SLNQDSNSNFKDTLLKEREAEVRNLKQNLS---------------ELEQLNENLKKVAFD 674

Query: 2363 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET-NF 2421
            +        M    L    + ++HQL+  +A            N +++  KN + ET   
Sbjct: 675  V-------KMENEKLVLACEDVRHQLEECLA-----------GNNQLSLEKNTIVETLKM 716

Query: 2422 KMNQLTQEL-FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ 2480
            +  ++  EL ++ KR  E   K +   E   N    + S  + E E ++  +  K +E  
Sbjct: 717  EKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIA 776

Query: 2481 TYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI 2540
               K+ E+        ++T   + +  +S+   E     KQ+  +  + +   E L+++ 
Sbjct: 777  ELKKNIEQ--------MDTDHKETKDVLSSSLEE----QKQLTQLINKKEIFIEKLKERS 824

Query: 2541 VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN-LNQLREDELGS 2599
              LQ+ +++   A   ++I  + ++E     +D    S + E  ++Q  L +LRE++  +
Sbjct: 825  SKLQEELDKYSQALRKNEILRQTIEE-----KDRSLGSMKEENNHLQEELERLREEQSRT 879

Query: 2600 DISA--LTL-RISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK 2656
               A   TL  ++EL S+V +++T     +E+++  +K + ++ +  ++L + L+  +K+
Sbjct: 880  APVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKE 939

Query: 2657 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ 2716
              E   +    +     T T+LF   +E     E+++L+      K +L   ++  +   
Sbjct: 940  MDEFRYQHEQMNA----THTQLFLEKDE-----EIKSLQKTIEQIKTQLHEERQDIQTDN 990

Query: 2717 EELLVKETNMTSLQKDLSQVRDHLAEAK-EKL--SILEKEDETEVQESKKACMFEPLPIK 2773
             ++  +ET + SL  +    +  L++A+ E+L   I E+E E ++   K   + + +  +
Sbjct: 991  SDIF-QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQID-Q 1048

Query: 2774 LSKS-------IASQTDGTL-----KISSSNQTPQILVKNAGIQINLQSECSSEEVTEII 2821
            LSK        I  Q D  +     +ISS++ T  ++     +Q         E+V  ++
Sbjct: 1049 LSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMER---EKVFAVL 1105

Query: 2822 SQFTEK-------IEKMQELHAAEIL---------------------DMESRHISETETL 2853
            ++ T +         KM ++ AA+                       DM    I     +
Sbjct: 1106 NEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI 1165

Query: 2854 KREHYVAVQLLKEECGTLKAVIQCLRS-KEGSSIPELAHSDAYQTREICSSD--SGSDWG 2910
             RE  + +  L ++C TL AV+Q   +  E   +      +  Q R+          +W 
Sbjct: 1166 IREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWK 1225

Query: 2911 QGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV--LSLTESPYSDG 2968
            Q +  T           + E ++   +    + + L+ + +N  +QV    L +S Y   
Sbjct: 1226 QQVMTT-------VQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQS-YEQN 1277

Query: 2969 EDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLL 3028
            E        E  L + +  I  + + KDL+    L +   +     S    +    E L 
Sbjct: 1278 ETKLKNFGQE--LAQVQHSIGQLCNTKDLL----LGKLDIISPQLSSASLLTPQSAECLR 1331

Query: 3029 ALQQVFLEERSVLLAAFRTELT-ALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR 3087
            A +   L E S LL     EL  +L   DA   +  L++          A  E L++ + 
Sbjct: 1332 ASKSEVLSESSELLQQELEELRKSLQEKDAT--IRTLQENNHRLSDSIAATSE-LERKEH 1388

Query: 3088 RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
                SEI+ L  + +  +  LK +    K   + L  + +   +++ E ++    ++   
Sbjct: 1389 EQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENEL----LRQAV 1444

Query: 3148 TELQEQLSSEKMVVAELKSE---LAQTKLELETTLKA-QHKHLKELEAFRLEVKDKTDEV 3203
            T L+E++   +M + +LK E   + +T    ET  +A Q  ++K    F + +++K  E 
Sbjct: 1445 TNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMK----FSMMLREKEFEC 1500

Query: 3204 HLLND-TLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLN-- 3260
            H + +  LA EQ          EKE+ K G        EL  L  +++S +++ +     
Sbjct: 1501 HSMKEKALAFEQLLK-------EKEQGKTG--------ELNQLLNAVKSMQEKTVVFQQE 1545

Query: 3261 ----LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
                +L  +QKQ+ N + Q  E QR L D +    Q        LLESE    RE  +  
Sbjct: 1546 RDQVMLALKQKQMENTALQN-EVQR-LRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603

Query: 3317 DRERELHAQ-------LQSSDGTGQSRPPLPS------EDLLKELQKQLEEKHSRIVELL 3363
            DRE +L  +       L SS    ++     S      ++ L  + KQ +E   ++    
Sbjct: 1604 DREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQ 1663

Query: 3364 NETEKYKLDSLQTRQQME----KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQR-- 3417
             + ++Y L     +  +E    +++ ++   L+ +++   E +K    L+ KV  LQ   
Sbjct: 1664 EQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECL 1723

Query: 3418 ---------------QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESR--RIL 3460
                           QL+ K +Q+ +L  + +  Q ++ + QK+ +      E +  ++L
Sbjct: 1724 DEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVL 1783

Query: 3461 YQNL 3464
             +NL
Sbjct: 1784 MRNL 1787



 Score =  170 bits (430), Expect = 3e-41
 Identities = 356/1701 (20%), Positives = 699/1701 (41%), Gaps = 260/1701 (15%)

Query: 1300 EETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK--TKLEEQVQELESLISSLQQQLKET 1357
            E TE +      +  ++I+  H    S  + L+K  T LEE+ +  E  I       +  
Sbjct: 40   EGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQ 99

Query: 1358 EQNYEAEIHCLQKR----------LQAVSESTVPPSLPVDSVVITESDAQR-TMYPGSCV 1406
             Q  E EI  L+ R          LQ+ ++S VP    V +   + S A   + +P +  
Sbjct: 100  LQQKEVEISHLKARQIALQDQLLKLQSAAQS-VPSGAGVPATTASSSFAYGISHHPSAFH 158

Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
              ++D     S +  +   +N V  LE +        +A+   +     + Q+E+ ++  
Sbjct: 159  DDDMDFGDIISSQQEINRLSNEVSRLESEVGHW--RHIAQTSKAQGTDNSDQSEICKLQN 216

Query: 1467 G----KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG 1522
                 K+N +     H          ++ KL++  I  +  E +   ++E  + L   L 
Sbjct: 217  IIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTE--ISRRHREELS-DYEERIEELENLLQ 273

Query: 1523 EHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS-----VSSMDAS 1577
            + G  ++   +D   I E +  +  +  E     K     + + D+I      +SS +  
Sbjct: 274  QGGSGVI--ETDLSKIYEMQKTIQVLQIEKVESTKKM---EQLEDKIKDINKKLSSAEND 328

Query: 1578 RQLMLNE-EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ-----EEIK 1631
            R ++  E EQL   +++++ + +  +     L+ + ++Q +   E +  L      EE+ 
Sbjct: 329  RDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVF 388

Query: 1632 RLNRQLAQR-------SSIDNENLVSERERVLLEELEAL-KQLSLAGREKLCCELRNSST 1683
            RL + L+         SS++ +N ++E    L   +E L K+ SL  +EK   EL+ S  
Sbjct: 389  RLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKE--ELQMSLL 446

Query: 1684 QTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTA 1743
            +  N  E    ++    ++  LD +  D+   + + E+   Q  + +  + L+  ++   
Sbjct: 447  KLNNEYE---VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEK--ETLIAEIEELD 501

Query: 1744 AVEETIGRHVLGILDRSSKSQSSA-SLIWRSEAEAS-VKSCVHE------EHTRVTDESI 1795
               +   +H++ I D+ SK Q+   S+I + + + +  K  VH+      + T+  D   
Sbjct: 502  RQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQK 561

Query: 1796 PSYSGSDMPRNDINMWSKVTEEGTE-LSQRLVRSGFAGTEIDPENEELMLNI---SSRLQ 1851
                 S++  ND+++  +  E+  E L  +L +S  +   I  EN EL  +I      L 
Sbjct: 562  EKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 621

Query: 1852 AAVEKLLEAISETSSQ--------------------LEHAKVTQTELMRESFRQKQEATE 1891
                +L++++++ S+                     L   +     L + +F  K E  +
Sbjct: 622  RIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEK 681

Query: 1892 SLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQE 1951
             +   E++R +L E      QL++E             + T+ E    EK +I    E E
Sbjct: 682  LVLACEDVRHQLEECLAGNNQLSLE-------------KNTIVETLKMEKGEI----EAE 724

Query: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
            L  A  RL E   E  + ++  E LS  +    +      + L++  +K   E  E++  
Sbjct: 725  LCWAKKRLLE---EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781

Query: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
             E++  D ++    L   +EEQ  +  +L  +K   +  L++++  L+++L+K  + L +
Sbjct: 782  IEQMDTDHKETKDVLSSSLEEQ-KQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840

Query: 2072 QAIDRE-------------HERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2118
              I R+              E +  Q+E+++L ++     R  P+++ +T +       +
Sbjct: 841  NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS---RTAPVADPKTLD------SV 891

Query: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGA 2178
             E   + S+L   KE L+ +I+   + IE       +L Q+L          E +K    
Sbjct: 892  TELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQ---------EQKKEMDE 942

Query: 2179 VEAKPEL--SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2236
               + E   +   QL  E+D      +EI +L++ +EQ + +L  + +++Q  +  +  +
Sbjct: 943  FRYQHEQMNATHTQLFLEKD------EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQE 996

Query: 2237 KKESTTRLQELEQENKLFKDDMEKLGLAIKESD-----------AMSTQDQHVL---FGK 2282
             K  +  ++   +++ L K + E+L   IKE +           +++ Q   +     GK
Sbjct: 997  TKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGK 1056

Query: 2283 FAQIIQEKEVEIDQLN---------EQVTKLQQQLKITTDNK-----VIEEKNELIRDLE 2328
              QIIQ+K++EI  L+         + V  LQQQL+     +     V+ EK      L+
Sbjct: 1057 LTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLK 1116

Query: 2329 TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQ----KTSMNAHSLSEEADSL 2384
            T+   +M     +   +E  + +L +  +KL     + GQ    +T  N   +  E D  
Sbjct: 1117 TEYHKMMD----IVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIE 1172

Query: 2385 KHQLDVVIAEKLALEQQVETAN----------EEMTFMKNVLKETNFKMNQLTQELFSL- 2433
               L       LA+ Q   T N          EE+   ++ LK+   KM +  Q++ +  
Sbjct: 1173 IDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTV 1232

Query: 2434 -KRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF------ 2486
               + ES +  + + +    V +D  S +  +L+V  T       +N+T  K+F      
Sbjct: 1233 QNMQHESAQLQEELHQLQAQVLVD--SDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQ 1290

Query: 2487 EENGKGSIINLETRLL--------QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2538
             ++  G + N +  LL        QL S+ S    +  +C +  K   E     +E+LQ+
Sbjct: 1291 VQHSIGQLCNTKDLLLGKLDIISPQL-SSASLLTPQSAECLRASK--SEVLSESSELLQQ 1347

Query: 2539 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQ----NLNQLRE 2594
            ++  L+K ++EK A        +  +QE      D+   +SE ER   +     + QL+E
Sbjct: 1348 ELEELRKSLQEKDAT-------IRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKE 1400

Query: 2595 --DELGSDISALTLRISELESQVV---EMHTSLILEKEQVEIAEKNVLEKEKKL-LELQK 2648
              D L   +    L I     Q++   E  T+ + E E +  A  N+ E+   L +++ K
Sbjct: 1401 KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGK 1460

Query: 2649 LLEGNEK-------KQRE---------------KEKKRSPQDVEVLKTTTELFHSNEESG 2686
            L   NEK       K+ E               +EK+     ++      E     +E G
Sbjct: 1461 LKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQG 1520

Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
               EL  L     + + +   ++++ +++   L  K+   T+LQ ++ ++RD    + ++
Sbjct: 1521 KTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQE 1580

Query: 2747 LSILEKE-DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
            L  L     E+E   +++A   E    KL K +    +    +SSSN      ++NA  Q
Sbjct: 1581 LERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKL--VSSSN-----AMENASHQ 1633

Query: 2806 INLQSECSSEEVTEIISQFTE 2826
             ++Q E   E++  +  Q  E
Sbjct: 1634 ASVQVESLQEQLNVVSKQRDE 1654



 Score =  159 bits (401), Expect = 7e-38
 Identities = 382/1896 (20%), Positives = 760/1896 (40%), Gaps = 289/1896 (15%)

Query: 601  EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
            +ML +    V   + +S+  E+E +   +L S  E L KL  DLE +H  +         
Sbjct: 36   DMLMEGTEEVEAELPDSRTKEIEAIHA-ILRSENERLKKLCTDLEEKHEAS--------E 86

Query: 661  IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTL- 719
            I  KQQ    +N++ QK   +   K   I  Q+QL+    KL+   QS+ +      T  
Sbjct: 87   IQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLL----KLQSAAQSVPSGAGVPATTA 142

Query: 720  ------------------------------QINELQKEIEILRQE----------EKEKG 739
                                          +IN L  E+  L  E           K +G
Sbjct: 143  SSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQG 202

Query: 740  TLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD-EKKTLEDMLKIHTP-- 796
            T   +  E+      L+  +KE + +  ++    + E S+L++  ++ L ++ + H    
Sbjct: 203  TDNSDQSEIC----KLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREEL 258

Query: 797  VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN 856
               EER+  L+++  +    V E ++  + E  + +  Q +Q+ E++E  +      +K 
Sbjct: 259  SDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTI--QVLQI-EKVESTKKMEQLEDKI 315

Query: 857  FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE----ELHLQRINPTTVKM 912
             ++N +        L   ++D +  + +QE     K + + E    +L   ++ P+ VK 
Sbjct: 316  KDINKK--------LSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK- 366

Query: 913  KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972
            +S    E +  +A++  + EV          + E+ +   L     L++ + +LK +   
Sbjct: 367  QSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMR--- 423

Query: 973  ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE 1032
            I  L +E   L QEKE++ +   +L     +N  E ++S  T+  S LD  +       E
Sbjct: 424  IEVLEKEKSLLSQEKEELQMSLLKL-----NNEYEVIKSTATRDIS-LDSELHDLRLNLE 477

Query: 1033 GSVSKVNKSFGEESKIMVE-DKVSFENMTVGEESKQEQLILDHLPSVTKE--SSLRATQP 1089
                ++N+S  E+  ++ E +++  +N    E +K   LI D L     E  S +   + 
Sbjct: 478  AKEQELNQSISEKETLIAEIEELDRQNQ---EATKHMILIKDQLSKQQNEGDSIISKLKQ 534

Query: 1090 SENDKLQKELNVLKSEQNDL--RLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147
              ND+ +K ++ L+ ++ D+   L ++ +++  S V    +   ++ +E++ +    +L 
Sbjct: 535  DLNDE-KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVE----NLV 589

Query: 1148 EELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLC 1207
            ++L  +QE  +  +QK   LEL+    Q   +  +  + L+  L +   +  S F  TL 
Sbjct: 590  DQLNKSQESNV-SIQK-ENLELKEHIRQNEEELSRIRNELMQSLNQ---DSNSNFKDTL- 643

Query: 1208 SVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY 1267
              L E        + N  + E     ++EN    L+   ++V+   E +      V  + 
Sbjct: 644  --LKEREAEVRNLKQNLSELEQ----LNEN----LKKVAFDVKMENEKLVLACEDVRHQL 693

Query: 1268 NKLLVLQTRLSKIWGQQTDGMKLEFGE---------ENLPKEETEFLSIHSQMTNLEDID 1318
             + L    +LS       + +K+E GE         + L +E  ++     +++N  +++
Sbjct: 694  EECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLN 753

Query: 1319 VN-------HKSKLSSLQDLEKTKLEEQVQELES--------LISSL--QQQLKETEQNY 1361
             +       H  KL+  +D+E  +L++ ++++++        L SSL  Q+QL +     
Sbjct: 754  TSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKK 813

Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
            E  I  L++R   + E                    + +     +++ I+      G   
Sbjct: 814  EIFIEKLKERSSKLQEEL--------------DKYSQALRKNEILRQTIEEKDRSLG--S 857

Query: 1422 VKEETN-IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAV 1480
            +KEE N + + LE+  +EQ          ++       +E+S+++  KE+     + H  
Sbjct: 858  MKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQK 917

Query: 1481 CQQEQHY--------FNEMKLSQDQIGFQ------TFETVDVKFKEEFKPLSK------- 1519
              ++Q+           E K   D+  +Q      T   + ++  EE K L K       
Sbjct: 918  IIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKT 977

Query: 1520 ELGEHGKEILLSNSDPHDIPESKDCVLTI----SEEMFSKDKTFIVRQSIHDEISVSSMD 1575
            +L E  ++I   NSD     E+K   L I     +   SK +T  + + I +      + 
Sbjct: 978  QLHEERQDIQTDNSD--IFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLL 1035

Query: 1576 ASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQRED-----QEQLQEEI 1630
              + + L ++  +  + E+ +  Q  QQ    ++  H R             Q+QLQ   
Sbjct: 1036 NEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYA 1095

Query: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNE 1690
                +  A  +    EN   + E   + ++ A K+ +L    KL  E +  ST+ ++  +
Sbjct: 1096 MEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALI---KLQDENKKLSTRFESSGQ 1152

Query: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
               ++  +T +      + +D+  + LS +            + LL V++T++   E  G
Sbjct: 1153 ---DMFRETIQNLSRIIREKDIEIDALSQK-----------CQTLLAVLQTSSTGNEAGG 1198

Query: 1751 ------RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMP 1804
                    +L   D+  K Q      W+ +   +V++  HE  +    E +       + 
Sbjct: 1199 VNSNQFEELLQERDK-LKQQVKKMEEWKQQVMTTVQNMQHE--SAQLQEELHQLQAQVLV 1255

Query: 1805 RNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISET 1864
             +D N  SK+  + T L Q              +NE  + N    L      + +  +  
Sbjct: 1256 DSDNN--SKLQVDYTGLIQSY-----------EQNETKLKNFGQELAQVQHSIGQLCNTK 1302

Query: 1865 SSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924
               L    +   +L   S    Q A E L+  +   E L E S   +Q   EL K+    
Sbjct: 1303 DLLLGKLDIISPQLSSASLLTPQSA-ECLRASKS--EVLSESSELLQQELEELRKS---- 1355

Query: 1925 DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQ-----QQIQEERELLSRQ 1979
                 EK    R +QE    +     + + A++ L+  E EQ     +Q++E++++L + 
Sbjct: 1356 ---LQEKDATIRTLQENNHRL----SDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKL 1408

Query: 1980 KEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDV---EEQVSR 2036
             +           QLL   E    +  E +   + V  +L++++  LE+D+   + +  +
Sbjct: 1409 LKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAV-TNLKERILILEMDIGKLKGENEK 1467

Query: 2037 FIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKV 2096
             +E  + K TE   L++ N      L            ++E E    +++    EQ LK 
Sbjct: 1468 IVETYRGKETEYQALQETNMKFSMMLR-----------EKEFECHSMKEKALAFEQLLK- 1515

Query: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVREL 2156
                    + +T E+ QL N +K   +K       ++Q+   ++++  E   L+  V+ L
Sbjct: 1516 -----EKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRL 1570

Query: 2157 EQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFR 2216
                  S    +++  R H   +E++   + E     +R+A  +  K++T LEE+L    
Sbjct: 1571 RDKEFRSNQELERL--RNHL--LESEDSYTREALAAEDREA--KLRKKVTVLEEKLVSSS 1624

Query: 2217 EELENKNE----EVQQLHMQLEI---QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD 2269
              +EN +     +V+ L  QL +   Q+ E+  +L   +++ K +   +  L + ++   
Sbjct: 1625 NAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ 1684

Query: 2270 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLET 2329
                        K  Q+I E +   + L  +V  LQ+ L     N  ++  + L   L+ 
Sbjct: 1685 QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECL--DEANAALDSASRLTEQLDV 1742

Query: 2330 QIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN 2365
            + E +    E +KR  E   E L++V +KL   LAN
Sbjct: 1743 KEEQI----EELKRQNELRQEMLDDVQKKL-MSLAN 1773



 Score =  155 bits (391), Expect = 1e-36
 Identities = 363/1875 (19%), Positives = 769/1875 (41%), Gaps = 312/1875 (16%)

Query: 701  KLKDLQQSLVNSKSEEMTLQINELQ-KEIE----ILRQEEKEKGTLEQEVQELQLKTELL 755
            ++ +  + ++   +EE+  ++ + + KEIE    ILR E +    L++   +L+ K E  
Sbjct: 29   QISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENER---LKKLCTDLEEKHEAS 85

Query: 756  EKQMKEKENDLQEKFAQLEAENSILKDEKKTLED-MLKIHTPVSQEERLIFLDSIKSKSK 814
            E Q+K++    + +  Q E E S LK  +  L+D +LK+ +          + +  + S 
Sbjct: 86   EIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSS 145

Query: 815  --------------DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
                          D +   +I    +E   L  +  +L  E+   R+    ++     N
Sbjct: 146  FAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDN 205

Query: 861  YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
                Q E   L  +  +L+ +++++  +++ ++  L +  H Q++   + + +  + D +
Sbjct: 206  SD--QSEICKLQNIIKELKQNRSQEIDDHQHEMSVL-QNAHQQKLTEISRRHREELSDYE 262

Query: 921  KTF--VAETLEMGE--VVEKDTTEL-----------MEKLEVTKREKLELSQRLSDLSEQ 965
            +    +   L+ G   V+E D +++           +EK+E TK+ + +L  ++ D++++
Sbjct: 263  ERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKME-QLEDKIKDINKK 321

Query: 966  LKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025
            L     +   L  E + L  EK Q+   C  L++  +  +   V+  DT      + ++ 
Sbjct: 322  LSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEK--ERILA 379

Query: 1026 MTSRGAEGSVSKVNKSFGE-ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084
             ++   E  V ++ ++  + E++IM    ++ +N    +  K +  I      + KE SL
Sbjct: 380  QSASVEE--VFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRI----EVLEKEKSL 433

Query: 1085 RATQPSEND----KLQKELNVLKS----------EQNDLRLQMEAQRICLSLVYSTHVDQ 1130
             + +  E      KL  E  V+KS          E +DLRL +EA+   L+   S     
Sbjct: 434  LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETL 493

Query: 1131 VREYME-----NEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1185
            + E  E      E  K +  +K++L   Q E    + K+ Q         +  DE K +H
Sbjct: 494  IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---------DLNDEKKRVH 544

Query: 1186 LLIGK---LQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYISENEDPE 1241
             L      + K +  +    +Q+  ++   + T     +   EDK EN  D ++++++  
Sbjct: 545  QLEDDKMDITKELDVQKEKLIQSEVALNDLHLT-----KQKLEDKVENLVDQLNKSQESN 599

Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
            +   +       EN+  L   + +   +L  ++  L +   Q ++     F +  L + E
Sbjct: 600  VSIQK-------ENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNS---NFKDTLLKERE 648

Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKL----EEQVQELESLIS--------- 1348
             E  ++   ++ LE ++ N K K++    +E  KL    E+   +LE  ++         
Sbjct: 649  AEVRNLKQNLSELEQLNENLK-KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEK 707

Query: 1349 -SLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK 1407
             ++ + LK  +   EAE+   +KRL   +              I E    R +   +   
Sbjct: 708  NTIVETLKMEKGEIEAELCWAKKRLLEEANKY--------EKTIEELSNARNLNTSALQL 759

Query: 1408 KNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG 1467
            ++     E   +   K++  I +L +   Q   + +  K ++S S+   +Q +L+++   
Sbjct: 760  EH-----EHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLE--EQKQLTQLINK 812

Query: 1468 KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKF---KEEFKPLSKELGEH 1524
            KE      +  +   QE+       L +++I  QT E  D      KEE   L +EL   
Sbjct: 813  KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERL 872

Query: 1525 GKEILLSNSDPHDIPESKDCVLTISEEMFSKD--KTFIVRQSIHDEISVSSMDASRQLML 1582
             +E   S + P   P++ D V  ++ E+   +  K  +  +  H +  +   + S+  +L
Sbjct: 873  REE--QSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL 930

Query: 1583 NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSS 1642
              + L++ ++E+     +H+Q    +   H +    + E+ + LQ+ I+++  QL +   
Sbjct: 931  --QSLQEQKKEMDEFRYQHEQ----MNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE--- 981

Query: 1643 IDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT--- 1699
                    ER+ +  +  +  +            E +  S   +NG+E     + +T   
Sbjct: 982  --------ERQDIQTDNSDIFQ------------ETKVQSLNIENGSEKHDLSKAETERL 1021

Query: 1700 ---FKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGI 1756
                KE+EL+ K       +L+ +  +L K  ++L K   EV K T  +++     +  +
Sbjct: 1022 VKGIKERELEIK-------LLNEKNISLTKQIDQLSKD--EVGKLTQIIQQK-DLEIQAL 1071

Query: 1757 LDRSSKSQSSASLIWRSEA------EASVKSCVHEEHTRVTDESIPSYSGS-DMPRNDIN 1809
              R S +  +  +++  +       E      V  E TR        Y    D+      
Sbjct: 1072 HARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEA 1131

Query: 1810 MWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL------LEAISE 1863
               K+ +E  +LS R   SG    ++  E  + +  I       ++ L      L A+ +
Sbjct: 1132 ALIKLQDENKKLSTRFESSG---QDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQ 1188

Query: 1864 TSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL--------HEESRAREQL-- 1913
            TSS    A    +    E  +++ +  + +K  EE ++++        HE ++ +E+L  
Sbjct: 1189 TSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQ 1248

Query: 1914 --------AVELSKAE----GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQE 1961
                    +   SK +    G+I  Y   +T  +   QE   +   + Q        L +
Sbjct: 1249 LQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGK 1308

Query: 1962 LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK 2021
            L+    Q+     L  +  E ++A     + ++L E+ +L++++LE   ++ + +D   +
Sbjct: 1309 LDIISPQLSSASLLTPQSAECLRAS----KSEVLSESSELLQQELEELRKSLQEKDATIR 1364

Query: 2022 QVKALEIDVEEQVSRFIELEQEKN----TELMDLRQQNQALEKQLEKMRKFL-------- 2069
             ++     + + ++   ELE++++    +E+  L+++   L+K L++    +        
Sbjct: 1365 TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLL 1424

Query: 2070 --DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
              +E   ++ +E ++ +Q +  L++++ ++              E     LK + +K  E
Sbjct: 1425 SSNENFTNKVNENELLRQAVTNLKERILIL--------------EMDIGKLKGENEKIVE 1470

Query: 2128 LLLSKEQLQRDIQERNEEIEKL----EFRVRELEQALLVSADTFQKVEDRKH------FG 2177
                KE   + +QE N +   +    EF    +++  L      ++ E  K         
Sbjct: 1471 TYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLN 1530

Query: 2178 AVEAKPELSLEVQLQAERD----AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2233
            AV++  E +  V  Q ERD    A+ +K+ E T L+ ++++ R++    N+E+++L   L
Sbjct: 1531 AVKSMQEKT--VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHL 1588

Query: 2234 EIQKKESTTR--LQELEQENKLFKDDMEKLGLAIKESDAM------------STQDQHVL 2279
             ++ ++S TR  L   ++E KL K         +  S+AM            S Q+Q  +
Sbjct: 1589 -LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNV 1647

Query: 2280 FGK----FAQIIQEKEVEIDQLNEQVTKLQ------QQLKITTDNKVIEEKNELIRDLET 2329
              K     A  +   + ++ Q    +  LQ      QQ +    +  +E++ +LI + + 
Sbjct: 1648 VSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKK 1707

Query: 2330 QIECL----MSDQECVKRN----------------REEEIEQLNEVIEKLQQELANIGQK 2369
              E L    +S QEC+                   +EE+IE+L    E  Q+ L ++ +K
Sbjct: 1708 NAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKK 1767

Query: 2370 TSMNAHSLSEEADSL 2384
                A+S   + D +
Sbjct: 1768 LMSLANSSEGKVDKV 1782



 Score =  154 bits (389), Expect = 2e-36
 Identities = 326/1661 (19%), Positives = 671/1661 (40%), Gaps = 278/1661 (16%)

Query: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF 1304
            +R E+ D++E +  L N + +  +   V++T LSKI+  Q     L+  +    K+    
Sbjct: 254  HREELSDYEERIEELENLLQQGGSG--VIETDLSKIYEMQKTIQVLQIEKVESTKK---- 307

Query: 1305 LSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAE 1364
                  M  LED   +   KLSS ++       EQ Q     ++  ++Q+ E  +N + E
Sbjct: 308  ------MEQLEDKIKDINKKLSSAENDRDILRREQEQ-----LNVEKRQIMEECENLKLE 356

Query: 1365 IHCLQKRLQAVSES-TVPPSLPVDSVVITE--------SDAQRTMYPGSCVKKN---IDG 1412
               LQ      S++ T    +   S  + E        SDA+  +   S + ++    + 
Sbjct: 357  CSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAED 416

Query: 1413 TIEFSGEFGVKEETNIVKLLEKQYQEQL---------EEEVAKVIVSMSIAF-------- 1455
             ++      V E+    K L  Q +E+L         E EV K   +  I+         
Sbjct: 417  NLKLKMRIEVLEKE---KSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473

Query: 1456 ----AQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFK 1511
                A++ EL++    KE   +  +   + +Q Q     M L +DQ+  Q  E   +  K
Sbjct: 474  LNLEAKEQELNQSISEKETLIA--EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISK 531

Query: 1512 EEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISV 1571
                 L ++L +  K +     D  DI +  D                     +  E  +
Sbjct: 532  -----LKQDLNDEKKRVHQLEDDKMDITKELD---------------------VQKEKLI 565

Query: 1572 SSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIK 1631
             S  A   L L +++LED  + LV Q  + Q++   +++ ++   E  R+++E+L     
Sbjct: 566  QSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRN 625

Query: 1632 RLNRQLAQRSSID-NENLVSERE---RVLLEELEALKQLS----------LAGREKL--- 1674
             L + L Q S+ +  + L+ ERE   R L + L  L+QL+              EKL   
Sbjct: 626  ELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLA 685

Query: 1675 CCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKI 1734
            C ++R+   +   GN NQ  +E+ T  E  L  +  ++  E+   ++  L++AN      
Sbjct: 686  CEDVRHQLEECLAGN-NQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEAN------ 737

Query: 1735 LLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDES 1794
                 K    +EE      L                       S     HE   ++  + 
Sbjct: 738  -----KYEKTIEELSNARNLN---------------------TSALQLEHEHLIKLNQKK 771

Query: 1795 IPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV 1854
                  +++ +N   M +   E    LS  L            E ++ +  + ++ +  +
Sbjct: 772  --DMEIAELKKNIEQMDTDHKETKDVLSSSL------------EEQKQLTQLINKKEIFI 817

Query: 1855 EKLLEAISETSSQLEHAK--VTQTELMRESFRQKQEATESLK-----CQEELRERLHEES 1907
            EKL E  S+   +L+     + + E++R++  +K  +  S+K      QEEL     E+S
Sbjct: 818  EKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS 877

Query: 1908 RARE-----------QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
            R              +LA E+S+   +       K   E +I+    II+   Q  +   
Sbjct: 878  RTAPVADPKTLDSVTELASEVSQLNTI-------KEHLEEEIKHHQKIIEDQNQSKMQLL 930

Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
              LQE + E  + + + E ++     +  E     + L +  E++  +  E +   +   
Sbjct: 931  QSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDN 990

Query: 2017 DDLQKQVKALEIDVEE----------QVSRFIELEQEKNTELMDLRQQNQALEKQLEKM- 2065
             D+ ++ K   +++E           +  R ++  +E+  E+  L ++N +L KQ++++ 
Sbjct: 991  SDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLS 1050

Query: 2066 ------------RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP----RFQPISEHQTR 2109
                        +K L+ QA+          Q++  L+QQL+       +   +   +TR
Sbjct: 1051 KDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTR 1110

Query: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQK 2169
            E     +HLK +  K  +++ +KE     +Q+ N+   KL  R     Q      D F+ 
Sbjct: 1111 E----NSHLKTEYHKMMDIVAAKEAALIKLQDENK---KLSTRFESSGQ------DMFR- 1156

Query: 2170 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEE---QLEQFREELENKNEEV 2226
             E  ++   +  + ++ ++   Q  +  +   +   T  E       QF E L+ +++  
Sbjct: 1157 -ETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLK 1215

Query: 2227 QQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI 2286
            QQ+  ++E  K++  T +Q ++ E+   ++++ +L   +   D+ +     V +    Q 
Sbjct: 1216 QQVK-KMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLV-DSDNNSKLQVDYTGLIQS 1273

Query: 2287 IQEKEVEIDQLNEQVTKLQQQL-KITTDNKVIEEKNELIRDLETQIECLMSDQ-ECVKRN 2344
             ++ E ++    +++ ++Q  + ++     ++  K ++I    +    L     EC++ +
Sbjct: 1274 YEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRAS 1333

Query: 2345 REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEE----ADSLKHQLDVVIAEKLALEQ 2400
            + E + + +E++++  +EL    Q+      +L E     +DS+    ++   E    + 
Sbjct: 1334 KSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDS 1393

Query: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKR-------ERESVEK-IQSIPENSVN 2452
            +++   E+   ++ +LKE +  +   + +L S          E E + + + ++ E  + 
Sbjct: 1394 EIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILI 1453

Query: 2453 VAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSII---------NLETRLLQ 2503
            + +D + K K E E ++     K  E Q      E N K S++         +++ + L 
Sbjct: 1454 LEMD-IGKLKGENEKIVETYRGKETEYQALQ---ETNMKFSMMLREKEFECHSMKEKALA 1509

Query: 2504 LESTVSAKDL----ELTQCYKQIKDMQEQ--------GQFETEMLQKKIVN--LQKIVEE 2549
             E  +  K+     EL Q    +K MQE+         Q    + QK++ N  LQ  V+ 
Sbjct: 1510 FEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQR 1569

Query: 2550 KVAAALVSQIQLEAVQEYAKFCQDNQT---ISSEPERTNIQNLNQLREDELGSDISALTL 2606
                   S  +LE ++ +    +D+ T   +++E     ++    + E++L S  +A+  
Sbjct: 1570 LRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMEN 1629

Query: 2607 RISELESQVVEMHTSL-ILEKE------QVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659
               +   QV  +   L ++ K+      Q+ ++++ V +    L  LQ +LE  +    +
Sbjct: 1630 ASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ----Q 1685

Query: 2660 KEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEEL 2719
            +EK     ++E  K     +  N E+    E + +  +    +A  A   + A +L E+L
Sbjct: 1686 EEKAMYSAELEKQKQLIAEWKKNAEN---LEGKVISLQECLDEANAAL--DSASRLTEQL 1740

Query: 2720 LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760
             VKE  +  L++     ++ L + ++KL  L    E +V +
Sbjct: 1741 DVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDK 1781



 Score =  142 bits (359), Expect = 5e-33
 Identities = 336/1805 (18%), Positives = 725/1805 (40%), Gaps = 261/1805 (14%)

Query: 374  KNMKLELTNSKQKE--------RQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425
            + ++ EL +S+ KE        R  +E +K+L   +EE     H+ S+ +   +++    
Sbjct: 43   EEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEE----KHEASEIQ---IKQQSTS 95

Query: 426  TQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMK----------------TRHKG 469
             + +L+Q   E+  +  +QI    Q L  Q  AQ                     + H  
Sbjct: 96   YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155

Query: 470  EMENALRSYSNITVNEDQIKLMNVAINELNI------------KLQDT-NSQKEKLKEEL 516
               +    + +I  ++ +I  ++  ++ L              K Q T NS + ++ +  
Sbjct: 156  AFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQ 215

Query: 517  GLILEEKCALQRQLEDLVEELSFSREQIQ--------RARQTIAEQESKLNEAHKSLSTV 568
             +I E K    ++++D   E+S  +   Q        R R+ +++ E ++ E    L   
Sbjct: 216  NIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQG 275

Query: 569  ED--LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ-EAELERL 625
                ++ ++    E +K +++    +V + K K+E LE +   +  +++ ++ + ++ R 
Sbjct: 276  GSGVIETDLSKIYEMQKTIQVLQIEKVESTK-KMEQLEDKIKDINKKLSSAENDRDILRR 334

Query: 626  RTQLLFSHEEELSKLKEDLEIE-HRINIEKLKDNLGIHYKQQI--------------DGL 670
              + L   + ++ +  E+L++E  ++    +K +  +  K++I                L
Sbjct: 335  EQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQAL 394

Query: 671  QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
             +  ++ +      +DN + + N  +    ++ + ++SL++ + EE+ + + +L  E E+
Sbjct: 395  SDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEV 454

Query: 731  LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDM 790
            ++       +L+ E+ +L+L  E  E+++ +  ++ +   A++E    + +  ++  + M
Sbjct: 455  IKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIE---ELDRQNQEATKHM 511

Query: 791  LKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTF 850
            + I   +S+++     DSI SK K  + +++  +       L+   + + +E++ Q+   
Sbjct: 512  ILIKDQLSKQQN--EGDSIISKLKQDLNDEKKRV-----HQLEDDKMDITKELDVQKEKL 564

Query: 851  SFAE---KNFEVNYQELQEEYACLLKVKDDLEDSK---NKQELEYKSKLKALNEELH--- 901
              +E    +  +  Q+L+++   L+   +  ++S     K+ LE K  ++   EEL    
Sbjct: 565  IQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIR 624

Query: 902  ---LQRIN--------PTTVKMKSSVFDEDKTFVAETLEMGEVVEK---DTTELMEKLEV 947
               +Q +N         T +K + +     K  ++E  ++ E ++K   D     EKL +
Sbjct: 625  NELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL 684

Query: 948  T---KREKLE--------LSQRLSDLSEQLKQKHGEISF--------LNEEVKSLKQEKE 988
                 R +LE        LS   + + E LK + GEI          L EE    ++  E
Sbjct: 685  ACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIE 744

Query: 989  QVS----LRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGE 1044
            ++S    L    L++   H    N Q  D +++ L   +  M +   E +   ++ S  E
Sbjct: 745  ELSNARNLNTSALQLEHEHLIKLN-QKKDMEIAELKKNIEQMDTDHKE-TKDVLSSSLEE 802

Query: 1045 ESKI--MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT----------QPSEN 1092
            + ++  ++  K  F        SK ++ +  +  ++ K   LR T             EN
Sbjct: 803  QKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN 862

Query: 1093 DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQ---VREYMENE---KDKAL--- 1143
            + LQ+EL  L+ EQ+      + + +      ++ V Q   ++E++E E     K +   
Sbjct: 863  NHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQ 922

Query: 1144 CSLKEELIFAQEEKIKELQKIHQLELQTMKTQ-----ETGDEGKPLHLLIGKLQKAVSEE 1198
               K +L+ + +E+ KE+ +      Q   T      E  +E K L   I +++  + EE
Sbjct: 923  NQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEE 982

Query: 1199 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258
                      +  E    +L  E N  +K +     +E     +++   E++   E   +
Sbjct: 983  RQDIQTDNSDIFQETKVQSLNIE-NGSEKHDLSKAETERLVKGIKERELEIKLLNEKNIS 1041

Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318
            L  ++ +     +   T++ +    +   +       +   ++  +L    Q   +E   
Sbjct: 1042 LTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTS-HTQDVVYLQQQLQAYAMEREK 1100

Query: 1319 V----NHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQA 1374
            V    N K++ +S    E  K+ + V   E+ +  LQ + K+           L  R ++
Sbjct: 1101 VFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKK-----------LSTRFES 1149

Query: 1375 VSESTVPPSLPVDSVVITESDAQRTMYPGSC-VKKNIDGTIEFSGEFGVKEETNIVKLLE 1433
              +     ++   S +I E D +       C     +  T     E G        +LL 
Sbjct: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELL- 1208

Query: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKL 1493
             Q +++L+++V K+             +   S   +      QA  +   +    N  KL
Sbjct: 1209 -QERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSD----NNSKL 1263

Query: 1494 SQDQIG-FQTFETVDVKFK---EEFKPLSKELGE--HGKEILLSNSDPHD---------I 1538
              D  G  Q++E  + K K   +E   +   +G+  + K++LL   D             
Sbjct: 1264 QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLT 1323

Query: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDAS-RQLMLNEEQLED---MRQEL 1594
            P+S +C+     E+ S+    + ++      S+   DA+ R L  N  +L D      EL
Sbjct: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383

Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSE--- 1651
             R  +EH+Q       + ++Q++ +++  ++L +E   L +  + +    NEN  ++   
Sbjct: 1384 ER--KEHEQT-----DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNE 1436

Query: 1652 -----------RERVLLEELEALKQLSLAG-REKLCCELRNSSTQTQNGNE--------- 1690
                       +ER+L+ E++  K   L G  EK+    R   T+ Q   E         
Sbjct: 1437 NELLRQAVTNLKERILILEMDIGK---LKGENEKIVETYRGKETEYQALQETNMKFSMML 1493

Query: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
             + E E  + KEK L  +      ++L  +        N+LL  +  + + T   ++   
Sbjct: 1494 REKEFECHSMKEKALAFE------QLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERD 1547

Query: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810
            + +L +  +  ++ +  + + R   +    +   E       ES  SY+   +   D   
Sbjct: 1548 QVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE- 1606

Query: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870
             +K+ ++ T L ++LV S  A           M N S +    VE L E ++  S Q + 
Sbjct: 1607 -AKLRKKVTVLEEKLVSSSNA-----------MENASHQASVQVESLQEQLNVVSKQRDE 1654

Query: 1871 AKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930
              + Q  + +E  +Q   +  +L+   E     H +   +   + EL K + +I  +   
Sbjct: 1655 TAL-QLSVSQEQVKQYALSLANLQMVLE-----HFQQEEKAMYSAELEKQKQLIAEWKKN 1708

Query: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
                E ++    + +D     L  AS   ++L+ +++QI+E    L RQ E  +     V
Sbjct: 1709 AENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEE----LKRQNELRQEMLDDV 1764

Query: 1991 EQQLL 1995
            +++L+
Sbjct: 1765 QKKLM 1769



 Score =  124 bits (312), Expect = 1e-27
 Identities = 325/1630 (19%), Positives = 688/1630 (42%), Gaps = 247/1630 (15%)

Query: 2184 ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT- 2242
            ++ +E   + E +  D + KEI  +   L    E L+    ++++ H   EIQ K+ +T 
Sbjct: 36   DMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTS 95

Query: 2243 ---RLQELEQENKLFK-------DDMEKLGLAIKESDA-----MSTQDQHVLFG------ 2281
               +LQ+ E E    K       D + KL  A +   +      +T      +G      
Sbjct: 96   YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155

Query: 2282 -------KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2334
                    F  II  ++ EI++L+ +V++L+ ++          +        +++I  L
Sbjct: 156  AFHDDDMDFGDIISSQQ-EINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214

Query: 2335 MSDQECVKRNREEEIEQLNEVIEKL----QQELANIGQKTSMNAHSLSEEADSLKHQLD- 2389
             +  + +K+NR +EI+     +  L    QQ+L  I ++         E  + L++ L  
Sbjct: 215  QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274

Query: 2390 ------------VVIAEKLALEQQVE--TANEEMTFMKNVLKETNFKMNQLTQELFSLKR 2435
                        +   +K     Q+E   + ++M  +++ +K+ N K++    +   L+R
Sbjct: 275  GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334

Query: 2436 ERE--SVEKIQSIPENSVNVAIDHLSKDKP----------ELEVVLTEDALKSLENQTYF 2483
            E+E  +VEK Q I E   N+ ++  SK +P          E E +L + A  S+E     
Sbjct: 335  EQEQLNVEKRQ-IMEECENLKLE-CSKLQPSAVKQSDTMTEKERILAQSA--SVEEVFRL 390

Query: 2484 KSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2543
            +    + +  I+ L +  L  +++++  +L+L              +   E+L+K+   L
Sbjct: 391  QQALSDAENEIMRLSS--LNQDNSLAEDNLKL--------------KMRIEVLEKEKSLL 434

Query: 2544 QKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDIS- 2602
             +  EE   + L    + E ++  A      + IS + E  +++   + +E EL   IS 
Sbjct: 435  SQEKEELQMSLLKLNNEYEVIKSTA-----TRDISLDSELHDLRLNLEAKEQELNQSISE 489

Query: 2603 --ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2660
               L   I EL+ Q  E    +IL K+Q+    K   E +  + +L++ L  N++K+R  
Sbjct: 490  KETLIAEIEELDRQNQEATKHMILIKDQL---SKQQNEGDSIISKLKQDL--NDEKKRVH 544

Query: 2661 EKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL 2720
            + +    D+     T EL    E+     + E    +   TK +L   ++K E L ++L 
Sbjct: 545  QLEDDKMDI-----TKELDVQKEK---LIQSEVALNDLHLTKQKL---EDKVENLVDQLN 593

Query: 2721 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIAS 2780
              + +  S+QK+  ++++H+ + +E+LS +  E    + +   +   + L  +    + +
Sbjct: 594  KSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653

Query: 2781 QTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEIL 2840
                  ++   N+     +K     + +++E       ++  Q  E +    +      L
Sbjct: 654  LKQNLSELEQLNEN----LKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ------L 703

Query: 2841 DMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI 2900
             +E   I   ETLK E     ++  E C   K +++   +K   +I EL+++     R +
Sbjct: 704  SLEKNTI--VETLKME---KGEIEAELCWAKKRLLE-EANKYEKTIEELSNA-----RNL 752

Query: 2901 CSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSL 2960
             +S    +    I L   +  +IA   +  E     D+  K+ K +L +   E  Q+  L
Sbjct: 753  NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ---MDTDHKETKDVLSSSLEEQKQLTQL 809

Query: 2961 TESPYSDGEDHSIQQVSEPWLEERKAYI-NTISSLKDLITKMQLQREAEVYDSSQSHESF 3019
                         +++    L+ER + +   +      + K ++ R+  + +  +S  S 
Sbjct: 810  INK----------KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQT-IEEKDRSLGSM 858

Query: 3020 SDWRGELLLALQQVFLEE-RSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAA 3078
             +    L   L+++  E+ R+  +A  +T  +       V  LN +++ ++E+   +Q  
Sbjct: 859  KEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKI 918

Query: 3079 MECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3138
            +E  Q   +  LL  +Q    +M+  +   + EQ +   +Q              LE   
Sbjct: 919  IED-QNQSKMQLLQSLQEQKKEMD--EFRYQHEQMNATHTQ------------LFLEKDE 963

Query: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQ-TKLELETTLKAQHKH-LKELEAFRL-- 3194
            E+ S++    +++ QL  E+  +    S++ Q TK++         KH L + E  RL  
Sbjct: 964  EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023

Query: 3195 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3254
             +K++  E+ LLN+   S  K+  +L    + E  KL +  ++   E++ L   + S   
Sbjct: 1024 GIKERELEIKLLNEKNISLTKQIDQLS---KDEVGKLTQIIQQKDLEIQALHARISSTS- 1079

Query: 3255 RNLQLNLLLEQQKQLLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3311
             + Q  + L+QQ Q     ++K   + +++   ++ L  E  + +++    E+  ++++ 
Sbjct: 1080 -HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ- 1137

Query: 3312 MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3371
                 D  ++L  + +SS            +D+ +E  + L    SRI+      +  ++
Sbjct: 1138 -----DENKKLSTRFESS-----------GQDMFRETIQNL----SRII----REKDIEI 1173

Query: 3372 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431
            D+L  +       Q     LQT    N  G    ++     E+L ++ ++ +QQV K++ 
Sbjct: 1174 DALSQK------CQTLLAVLQTSSTGNEAGGVNSNQF----EELLQERDKLKQQVKKMEE 1223

Query: 3432 EGQRLQGIMQEFQKQ--ELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE 3489
              Q++   +Q  Q +  +L+ E  +   ++L  + N      L  D T   ++Q   + E
Sbjct: 1224 WKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNS---KLQVDYT--GLIQSYEQNE 1278

Query: 3490 TKESNYAKLIE--MNGGGTGCNHELEMIRQKLQCVASKL---QVLPQKASERLQFETAD- 3543
            TK  N+ + +    +  G  CN + +++  KL  ++ +L    +L  +++E L+   ++ 
Sbjct: 1279 TKLKNFGQELAQVQHSIGQLCNTK-DLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV 1337

Query: 3544 -DEDFIWVQENIDEIILQLQKLTG---QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHI 3599
              E    +Q+ ++E+   LQ+         E    +S S +  S  ER  +++ +    I
Sbjct: 1338 LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELER--KEHEQTDSEI 1395

Query: 3600 SQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREK 3659
             QL E+++ L+ ++ + +  I+            S   L+   N    + +E E+  +  
Sbjct: 1396 KQLKEKQDVLQKLLKEKDLLIK----------AKSDQLLSSNENFTNKV-NENELLRQAV 1444

Query: 3660 LTLQKSLKRAEAEVYKLKAELRNDSLLQTL-SPDSEHVTLKRIYGKY---LRAESF---- 3711
              L++ +   E ++ KLK E  N+ +++T    ++E+  L+    K+   LR + F    
Sbjct: 1445 TNLKERILILEMDIGKLKGE--NEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS 1502

Query: 3712 --RKALIYQK 3719
               KAL +++
Sbjct: 1503 MKEKALAFEQ 1512


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  171 bits (434), Expect = 1e-41
 Identities = 420/2043 (20%), Positives = 793/2043 (38%), Gaps = 308/2043 (15%)

Query: 1592 QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE----- 1646
            +E+V +     ++  LL    M  +   +E+ + LQ+E+ R+   LAQ  +  +E     
Sbjct: 52   REIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKY 111

Query: 1647 NLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQG-EVEEQTFKEKEL 1705
            N VSER    LE+   L+   L              TQ   G   Q  E+  Q  +E+  
Sbjct: 112  NAVSER----LEQALRLEPGEL-------------ETQEPRGLVRQSVELRRQLQEEQAS 154

Query: 1706 DRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS 1765
             R+      E    +   +Q+   ++L+      +    + E  G      L  +  SQ 
Sbjct: 155  YRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQD 214

Query: 1766 SASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRL 1825
              S + R E E    + + + +  + ++   + S +     DI    KVT + T   + L
Sbjct: 215  LESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIR---KVTNDWTRCRKEL 271

Query: 1826 VRSGFAGTEIDPENEELMLNISSRLQAAVEKLL---EAISETSSQLEHAKVTQTELMRES 1882
                 A    +        N  SRL     +++     +SE     E   +     +  +
Sbjct: 272  EHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELART 331

Query: 1883 FRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ--- 1939
             R  QEA   L     L E    E+   +Q  ++    E + D    EK L ++Q+Q   
Sbjct: 332  SRAVQEAGLGLSTGLRLAES-RAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDL 390

Query: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQIQEE--------RELLSRQKEAMKAEAGPVE 1991
            +K D+  R+  EL  A  RL++   E+ Q+ ++          L  +++ A++ E G   
Sbjct: 391  DKADLSARVT-ELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGL 449

Query: 1992 QQLLQETEKLMKEKLEVQCQ---AEKVRDDLQKQVKALE--------------------- 2027
            QQ L++  + +    E   Q   +E+  D     ++ L                      
Sbjct: 450  QQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRR 509

Query: 2028 -----IDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDV 2082
                       ++       ++  ++ D+R + +A +  L  +RK    Q  D E ER  
Sbjct: 510  GPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRK----QLSDSESERRA 565

Query: 2083 FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQER 2142
             ++++Q+L  +     +     E   REV++L +  +  + + S L  S +  Q+  +E 
Sbjct: 566  LEEQLQRLRDKTDGAMQAH---EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEEL 622

Query: 2143 NEEIEKLEFRVRELE-QALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK 2201
             +E EKL+    EL  Q   +  +    V+D         +    LE QL+ +R  + ++
Sbjct: 623  RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLE-QLEGKRSVLAKE 681

Query: 2202 EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKL 2261
              E+     +    R+ L+ +  EV +   + E  + E    + +L  E    +D + KL
Sbjct: 682  LVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKL 741

Query: 2262 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321
              A+ ES A    D                     LN  V +L             EE+ 
Sbjct: 742  S-ALNESLAQDKLD---------------------LNRLVAQL-------------EEEK 766

Query: 2322 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
              ++  + Q E     +  V R  +E +E+L     +L+QE+A  G + S+     ++EA
Sbjct: 767  SALQGRQRQAE----QEATVAREEQERLEEL-----RLEQEVARQGLEGSLRVAEQAQEA 817

Query: 2382 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE-SV 2440
                            LEQQ+ T   E + ++  L + + +++   QEL   +RE +  V
Sbjct: 818  ----------------LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861

Query: 2441 EKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL-ENQTYFKSFEENGKGSIINLET 2499
            E ++        +A +H       +++V  E   ++L E  T  +  +E  +GS+  ++ 
Sbjct: 862  EALERAAREKEALAKEHAGL---AVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQR 918

Query: 2500 RLLQLEST-----------VSAKDL---ELTQCYKQIKDMQEQGQFETEMLQKKIV---- 2541
            +L QLE+            + AK+    EL    +QI   QE+   + E++ +K+V    
Sbjct: 919  QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER 978

Query: 2542 ---------------NLQKIVEEKVAA---------ALVSQIQLEAVQEYAKFCQDNQTI 2577
                           +LQ++  EK AA          L SQ+Q E  +  A+   + + +
Sbjct: 979  EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEEL 1038

Query: 2578 SSEPERTNIQNLNQLREDEL----GSDISALTLRISE---LESQVVEMHTSLI---LEKE 2627
            S E     I  L Q R++ L         AL+L+ SE   L  +++    SL    LE E
Sbjct: 1039 SEE-----IAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEME 1093

Query: 2628 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGF 2687
            + +   ++  E+++  +        + + QRE+      Q+V  L+          +S  
Sbjct: 1094 RQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDS-C 1152

Query: 2688 FNELEALRAE-------SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ---VR 2737
              E E LR +           + EL   + K  + QE   V+      L++ L +    R
Sbjct: 1153 LREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKER 1212

Query: 2738 DHLAEAKEKLSILEKEDETE--------VQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2789
            + L  + E+L    K+ E+E          + +K  + E     + K       G  ++ 
Sbjct: 1213 EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVE 1272

Query: 2790 SSNQTPQILVKNAGIQIN-LQSECS--SEEVTEIISQFT--EKIEKMQELHAAEILDMES 2844
             S    +  ++    Q+  L SE +    E+ E+  +    E+ EK        +     
Sbjct: 1273 RSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLL 1332

Query: 2845 RHISETETLKREHYVAVQLLKEECGTLKA----VIQCLRSKEGSSIPELAHSDAYQTREI 2900
            +  +  E +++E  VA + L+E+ G  +     ++  L    G+   +L H+   + +  
Sbjct: 1333 KGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLE 1392

Query: 2901 CSSDSGSDWGQGIYLTHSQGFDIASEGR--GEESESATDSFPKKIK----GLLRAVHNEG 2954
             +    ++ G  +          A+EGR  G E+E A     ++      G LR+    G
Sbjct: 1393 AARAEAAELGLRLS---------AAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443

Query: 2955 MQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQ 3014
               L L  +P             +   E     +N+ S+L +     Q          + 
Sbjct: 1444 ---LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTL-ECSPGSQPPSPGPATSPAS 1499

Query: 3015 SHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVE 3074
                    RG L   LQ++   +R       RT+ +AL    A   +         +  +
Sbjct: 1500 PDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNRQLAE--MEAERDSATSRARQ 1555

Query: 3075 YQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE---LLEYNIQQKQS 3131
             Q A+   ++A RRS+   +  + A++  ++ +++R +   + + +    LE ++Q  +S
Sbjct: 1556 LQKAVAESEEA-RRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATES 1614

Query: 3132 QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE---LETTLKAQHKHLKE 3188
            ++   Q ++S MK   T+L+      K V+   +S   + +L+   LE  L+     L +
Sbjct: 1615 ELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1674

Query: 3189 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE-----RDK---- 3239
             EA    ++D+ D    L   +A  + K+  LQ  +E+    L + EE     RDK    
Sbjct: 1675 REAQAQALQDRVDS---LQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGL 1731

Query: 3240 -EELEDLKFSLESQKQRNLQLNLLL---EQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
             E L     SL S + +NL L   L   E  +Q+L   Q+++++ R        +     
Sbjct: 1732 TEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL---QERLDAARQALSEARKQSSSLG 1788

Query: 3296 LELQVL------LESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQ 3349
             ++Q L      LE ++V   E    L + RE+  Q Q  +        L +   L++ +
Sbjct: 1789 EQVQTLRGEVADLELQRV---EAEGQLQQLREVLRQRQEGEAAA-----LNTVQKLQDER 1840

Query: 3350 KQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ 3409
            + L+E+   +   L + E  K +  ++  ++EKDR   R+TL   +       +    L 
Sbjct: 1841 RLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLS 1900

Query: 3410 S--------------KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRE 3455
            +              ++ + QRQ+++   QV  L+      Q +  + Q+Q+LE +++ E
Sbjct: 1901 AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQ-LEVDAQQQQLELQQEVE 1959

Query: 3456 SRR 3458
              R
Sbjct: 1960 RLR 1962



 Score =  159 bits (402), Expect = 5e-38
 Identities = 402/1848 (21%), Positives = 753/1848 (40%), Gaps = 245/1848 (13%)

Query: 1569 ISVSSMDASRQLMLNEEQLEDM--RQELVRQYQEHQQATELLRQAHMRQMERQRE-DQEQ 1625
            +  + +  S  L L E + E    +Q L++   E Q   ++LR+  + Q + Q + D+  
Sbjct: 335  VQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKAD 394

Query: 1626 LQEEIKRLNRQLAQRSSIDNENLVSER-ERVLLEELEALKQLSLAGREKLCCELRNSSTQ 1684
            L   +  L   + +   ++ +NL  ++  + L E+LEAL+ L L  +  L  E       
Sbjct: 395  LSARVTELGLAVKR---LEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETE------- 444

Query: 1685 TQNGNENQGEVEEQTFKE-KELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTA 1743
                    GE  +QT ++  +      +   ++  +ER A   A+N  L+ L      + 
Sbjct: 445  -------DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTA--DASNGSLRGLSGQRTPSP 495

Query: 1744 AVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDM 1803
                + GR   G   R   S + +     S   A + S +H+   +V D      +  D+
Sbjct: 496  PRRSSPGR---GRSPRRGPSPACSD----SSTLALIHSALHKRQLQVQDMRGRYEASQDL 548

Query: 1804 PRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863
                    S    E   L ++L R           +E+    +  RL++A E L    S 
Sbjct: 549  LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ-RLRSANELLSREKSN 607

Query: 1864 TSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGV 1923
             +  L+ A+  Q E +R+   + Q A E L+ Q   R+RL EE              + V
Sbjct: 608  LAHSLQVAQ-QQAEELRQEREKLQAAQEELRRQ---RDRLEEEQE------------DAV 651

Query: 1924 IDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK--- 1980
             DG         R+++     +++LE +    +  L E+     +   +R++L  +K   
Sbjct: 652  QDG-----ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706

Query: 1981 -EAM-KAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI 2038
             EA+ KAEAG VE +L     KL  E+  +Q    K+   L + +   ++D+   V+   
Sbjct: 707  AEALTKAEAGRVELEL--SMTKLRAEEASLQDSLSKL-SALNESLAQDKLDLNRLVA--- 760

Query: 2039 ELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
            +LE+EK+      RQ  Q      E+  + L+E  +++E  R       Q LE  L+V  
Sbjct: 761  QLEEEKSALQGRQRQAEQEATVAREEQER-LEELRLEQEVAR-------QGLEGSLRVAE 812

Query: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ-LQRDIQERNEEIEKLEFRVRELE 2157
            + Q   E Q   +    + L+E+  + S  L  +EQ L++  +E   ++E LE   RE E
Sbjct: 813  QAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKE 872

Query: 2158 QALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
                                   AK    L VQL A     +R+ + ++    +L   +E
Sbjct: 873  AL---------------------AKEHAGLAVQLVAA----EREGRTLSEEATRLRLEKE 907

Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
             LE    EVQ+   QLE ++++     Q L    +    ++  L   I  +   ++ D+ 
Sbjct: 908  ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKE 967

Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
            ++  K  Q  +E +     L EQ    ++ L+     ++  EK    R+LE +   L S 
Sbjct: 968  LMAQKLVQAEREAQAS---LREQRAAHEEDLQ-----RLQREKEAAWRELEAERAQLQSQ 1019

Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTS---MNAHSLSEEADSLKHQLDVVIAE 2394
               ++R +EE + +L    E+L +E+A + Q+     + A S  ++A SLK      ++E
Sbjct: 1020 ---LQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSE 1076

Query: 2395 KL-ALEQQVETANEEMTFMKNVLK----ETNFKMNQLTQELFSLKRERESV-----EKIQ 2444
            KL      + T + EM   K   +    +    +N LT EL  L+ +RE       ++++
Sbjct: 1077 KLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR 1136

Query: 2445 SIPENSVNVAI--DHLSKDKPEL--EVVLTEDALKSLENQTYF--KSFEENGKG-SIINL 2497
             + E + ++    D   ++  EL  ++ L EDA   L  +     +   E+ +G  +   
Sbjct: 1137 RLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQ 1196

Query: 2498 ETRLLQLESTVSAKDLE-LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
            E   L+      AK+ E L +  ++++   ++   E+E +  K+ N  K  E+K+A    
Sbjct: 1197 EAGELRRSLGEGAKEREALRRSNEELRSAVKKA--ESERISLKLANEDK--EQKLA---- 1248

Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
              +  EA     K   + +T   E ER+ ++   +L+E  L   +  L    + L  ++ 
Sbjct: 1249 --LLEEARTAVGKEAGELRTGLQEVERSRLEARRELQE--LRRQMKMLDSENTRLGRELA 1304

Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
            E+   L L +   + + +  L   ++LL+ +  LE   ++ +  ++K   Q+ E      
Sbjct: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364

Query: 2677 ELFHSNEES------------GFFNELEALRAESVATKAELASYKEKAEKLQEELLVKET 2724
             L  S EE+            G   +LEA RAE+      L++ + +A+ L+ EL   E 
Sbjct: 1365 RLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEV 1424

Query: 2725 NMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDG 2784
               + +  L  +R  L   +  L +             +A    P P+  S +  +  +G
Sbjct: 1425 QRRAAEAQLGGLRSAL---RRGLGL------------GRAPSPAPRPVPGSPARDAPAEG 1469

Query: 2785 ---------TLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELH 2835
                     TL+ S  +Q P      +    +L  E     + E + +      +  EL 
Sbjct: 1470 SGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELR 1529

Query: 2836 A------AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPEL 2889
                    ++ +ME+   S T +  R+   AV   +E   ++   +  ++++       +
Sbjct: 1530 TQTSALNRQLAEMEAERDSAT-SRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESV 1588

Query: 2890 AHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE--GRGEESESATDSFPKKIKGLL 2947
              S+  +   +   D  +   + +  T S+    + E   + + +E+  +   +++K +L
Sbjct: 1589 RRSERERRATL---DQVATLERSLQATESE-LRASQEKISKMKANETKLEGDKRRLKEVL 1644

Query: 2948 RAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREA 3007
             A  +E   V    +    +GE     Q S   L +R+A      +L+D +  +Q Q   
Sbjct: 1645 DA--SESRTVKLELQRRSLEGE----LQRSRLGLSDREA---QAQALQDRVDSLQRQ--- 1692

Query: 3008 EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTAL-----GTTDAVGLLN 3062
             V DS            E+     Q+ +E  +  LA       AL     G T+A+   +
Sbjct: 1693 -VADS------------EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSS 1739

Query: 3063 CLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ-EL 3121
                  +++ +  Q A+   +  DR+ L   + A       + ++  R+Q S    Q + 
Sbjct: 1740 ASLNSTRDKNLHLQKALTACEH-DRQVLQERLDAAR-----QALSEARKQSSSLGEQVQT 1793

Query: 3122 LEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE--LAQTKL-ELETT 3178
            L   +   + Q +E + +L  +++   + QE  ++    V +L+ E  L Q +L  L+  
Sbjct: 1794 LRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRA 1853

Query: 3179 LKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS---E 3235
            L       +E+E   L ++     +    D +  E+ +S E    L  EK +L R+    
Sbjct: 1854 LAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGA 1913

Query: 3236 ERDKEELEDLKFSLESQ----KQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEE 3291
            E +  E +     LE+Q    +Q +    L ++ Q+Q L E QQ++E  R    AQ   E
Sbjct: 1914 ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL-ELQQEVERLR---SAQAQTE 1969

Query: 3292 QGRNLELQVLLESEKVR-IREMSSTLDRERELHAQLQSSDGTGQSRPP 3338
              R LE +     ++VR + E  STL  + +   +  S+  +  S PP
Sbjct: 1970 --RTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGPP 2015



 Score =  134 bits (337), Expect = 2e-30
 Identities = 407/2083 (19%), Positives = 833/2083 (39%), Gaps = 311/2083 (14%)

Query: 439  EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINEL 498
            EM     +Q + +L++Q ++++E++  + + E +     Y+ ++   +Q          L
Sbjct: 72   EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQA---------L 122

Query: 499  NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR------EQIQRARQTIA 552
             ++  +  +Q+ +     GL+  +   L+RQL++  E+ S+ R      E  QR  Q + 
Sbjct: 123  RLEPGELETQEPR-----GLV-RQSVELRRQLQE--EQASYRRKLQAYQEGQQRQAQLVQ 174

Query: 553  EQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD 612
              + K+ +  K  S +E    E     E ++  + +H  ++ +  I+LE  E++++A L 
Sbjct: 175  RLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEE-EQQRSASLA 233

Query: 613  RMAESQEAELERLRT--QLLFSHEEELSKLKEDL-----EIEHRINI-EKLKDNLGIHYK 664
            ++      +L++  +  Q L    E++ K+  D      E+EHR     + +++   ++ 
Sbjct: 234  QVNAMLREQLDQAGSANQAL---SEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFS 290

Query: 665  ----------QQIDGLQNEMSQKIETMQFEKDNLITKQNQLI----------LEISKLKD 704
                      +Q+ G +  +S   E   F + +L+    +L           L +S    
Sbjct: 291  NEHSRLLLLWRQVVGFRRLVS---EVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLR 347

Query: 705  LQQSLVNSKSEEMTLQINELQKEI--EILR---------QEEKEKGTLEQEVQELQLKTE 753
            L +S   +  E+  L   +L++++  ++LR         Q + +K  L   V EL L  +
Sbjct: 348  LAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVK 407

Query: 754  LLEKQMKEKE---NDLQEKFAQLEA----ENSILKDE-----KKTLEDMLKIHTPVSQEE 801
             LEKQ  EK+    DL EK   LE+    E + L+ E     ++TL D+ +    +S  E
Sbjct: 408  RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQ--AVLSDSE 465

Query: 802  RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQR-------NTFSFAE 854
              + L   +  +  S     +  L  +      +          +R       ++ + A 
Sbjct: 466  SGVQLSGSERTADAS--NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLAL 523

Query: 855  KNFEVNYQELQ-EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMK 913
             +  ++ ++LQ ++     +   DL  +  KQ  + +S+ +AL E+  LQR+   T    
Sbjct: 524  IHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQ--LQRLRDKTDGAM 581

Query: 914  SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI 973
             +  D  +  V       E++ ++ + L   L+V +++  EL Q    L    ++   + 
Sbjct: 582  QAHEDAQRE-VQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR 640

Query: 974  SFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGA-- 1031
              L EE +   Q+  +V    RELE   +H + E ++   + ++  L  V    SR    
Sbjct: 641  DRLEEEQEDAVQDGARVR---RELE--RSHRQLEQLEGKRSVLAKELVEVREALSRATLQ 695

Query: 1032 ----EGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLI-------------LDH 1074
                +   ++V ++  +     VE ++S   +   E S Q+ L              LD 
Sbjct: 696  RDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDL 755

Query: 1075 LPSVTKESSLRATQPSENDKLQKELNVLKSEQ---NDLRLQMEAQRICLSLVYSTHVDQV 1131
               V +    ++       + ++E  V + EQ    +LRL+ E  R            Q 
Sbjct: 756  NRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR------------QG 803

Query: 1132 REYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQ-TMKTQETGDEGKPLHLLIGK 1190
             E      ++A  +L+++L   + E+ +  +++ QL  Q + + QE     +     +  
Sbjct: 804  LEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA 863

Query: 1191 LQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN------EDPELQD 1244
            L++A  E+           L + +   L  ++ A ++E  G  +SE       E   L+ 
Sbjct: 864  LERAAREK---------EALAKEHA-GLAVQLVAAERE--GRTLSEEATRLRLEKEALEG 911

Query: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSK---------IWGQQTDGMKLEFGEE 1295
              +EVQ     +     ++  E   LL+ +  L+          I  Q+   +  E   +
Sbjct: 912  SLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQ 971

Query: 1296 NLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLK 1355
             L + E E         +L +    H+  L  LQ  ++    E   E   L S LQ++ +
Sbjct: 972  KLVQAERE------AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQE 1025

Query: 1356 ETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTM----YPGSCVKKNID 1411
            E     EAE   L + + A+ +         + +++ ES+ Q+ +       + + + + 
Sbjct: 1026 ELLARLEAEKEELSEEIAALQQER------DEGLLLAESEKQQALSLKESEKTALSEKLM 1079

Query: 1412 GTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENT 1471
            GT        ++ E    +  + Q +++ +      + S       Q E +  +  +E  
Sbjct: 1080 GTRHSLATISLEMER---QKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR 1136

Query: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGE--HGKEIL 1529
               +QA  + +Q      E +  + Q+  +  E      + E     ++L E   G+E+ 
Sbjct: 1137 RLQEQARDLGKQRDSCLREAEELRTQL--RLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194

Query: 1530 LSNSDP-----HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE 1584
               +        +  + ++ +   +EE+ S  K     +S    + +++ D  ++L L E
Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEELRSAVKK---AESERISLKLANEDKEQKLALLE 1251

Query: 1585 EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSID 1644
            E    + +E   + +   Q  E  R    R+++  R   + L  E  RL R+LA+   + 
Sbjct: 1252 EARTAVGKE-AGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE---LQ 1307

Query: 1645 NENLVSER-ERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEK 1703
                + ER E+    E   L+Q  L G   L  E+     Q       Q +++EQ  + +
Sbjct: 1308 GRLALGERAEKESRRETLGLRQRLLKGEASL--EVMRQELQVA-----QRKLQEQEGEFR 1360

Query: 1704 ELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSS-- 1761
              +R+      E    E+  L  A  R L++ LE  +  AA    +G  +     R+   
Sbjct: 1361 TRERRLLGSLEEARGTEKQQLDHA--RGLELKLEAARAEAA---ELGLRLSAAEGRAQGL 1415

Query: 1762 KSQSSASLIWRSEAEA---SVKSCVHE-----EHTRVTDESIPSYSGSDMPR----NDIN 1809
            +++ +   + R  AEA    ++S +                +P     D P       +N
Sbjct: 1416 EAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLN 1475

Query: 1810 MWSKV-TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQL 1868
              S +    G++       +  A  ++DPE           ++ A+ + L+ +     + 
Sbjct: 1476 SPSTLECSPGSQPPSPGPATSPASPDLDPE----------AVRGALREFLQELRSAQRER 1525

Query: 1869 EHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA 1928
            +  +   + L R+    + E   +     +L++ + E   AR  +       +G + G  
Sbjct: 1526 DELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSV-------DGRLSGVQ 1578

Query: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988
             E  L E  ++       R E+E     +++  LE   Q    E EL + Q++  K +A 
Sbjct: 1579 AELALQEESVR-------RSERERRATLDQVATLERSLQ--ATESELRASQEKISKMKAN 1629

Query: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048
              +   L+  ++ +KE L+   ++  V+ +LQ+  ++LE ++           Q     L
Sbjct: 1630 ETK---LEGDKRRLKEVLDAS-ESRTVKLELQR--RSLEGEL-----------QRSRLGL 1672

Query: 2049 MDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQT 2108
             D   Q QAL+ +++ +++    Q  D E +    Q  +++L   L  V   +     + 
Sbjct: 1673 SDREAQAQALQDRVDSLQR----QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKV 1728

Query: 2109 REV-EQLA------NHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161
            R + E LA      N  ++K     + L + E  ++ +QER      L+   + L +A  
Sbjct: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER------LDAARQALSEARK 1782

Query: 2162 VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK---EKEITNLEEQLEQFREE 2218
             S+   ++V+  +   A      +  E QLQ  R+ + ++   E    N  ++L+  R  
Sbjct: 1783 QSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL 1842

Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
            L+ +   +Q+   QLE +K+E       LE++    +  ++K    ++     S +D   
Sbjct: 1843 LQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDK----VEREKLRSHEDTVR 1898

Query: 2279 LFGKFAQI----------IQEKEVEIDQLNEQVTKLQQ-----QLKITTDNKVIEEKNEL 2323
            L  +  ++          + E + +I QL  QV  L+Q     QL++    + +E + E+
Sbjct: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958

Query: 2324 --IRDLETQIECLMSDQECVKRNREEEI-EQLNEVIEKLQQEL 2363
              +R  + Q E  +  +E   R R   + EQ++ +  +LQQEL
Sbjct: 1959 ERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001



 Score =  119 bits (297), Expect = 8e-26
 Identities = 222/1024 (21%), Positives = 414/1024 (40%), Gaps = 162/1024 (15%)

Query: 25   AQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPESTIM 84
            AQ   QS   K     + +     V      N+++ Q N+      + +ES  + E   +
Sbjct: 382  AQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL 441

Query: 85   RT------------LHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTN 132
             T            L    ++  E G  +   S    TAD  +  + G S   RT  P  
Sbjct: 442  ETEDGEGLQQTLRDLAQAVLSDSESGVQL---SGSERTADASNGSLRGLSG-QRTPSPPR 497

Query: 133  LLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQ 192
                               DS T L ++ S L  +Q +++++    E  +   GT   +Q
Sbjct: 498  RSSPGRGRSPRRGPSPACSDSST-LALIHSALHKRQLQVQDMRGRYEASQDLLGTLR-KQ 555

Query: 193  LQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLR 252
            L + E+  +        L   LQ+ R + D  M+   +   + Q+L+       A+E L 
Sbjct: 556  LSDSESERRA-------LEEQLQRLRDKTDGAMQAHEDAQREVQRLR------SANELL- 601

Query: 253  NSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQ 312
             S   S  A  LQ  QQ      Q EE     E  Q  +E+   Q   L+E       EQ
Sbjct: 602  -SREKSNLAHSLQVAQQ------QAEELRQEREKLQAAQEELRRQRDRLEE-------EQ 647

Query: 313  DKKVENSNK--EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
            +  V++  +   E++     +E+L  K     K+ +E+++ L+ A      LQ +  +  
Sbjct: 648  EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVA 707

Query: 371  Q-----EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425
            +     E   ++LEL+ +K +  ++S     L  ++ +L   N   +Q + D+       
Sbjct: 708  EALTKAEAGRVELELSMTKLRAEEAS-----LQDSLSKLSALNESLAQDKLDL------- 755

Query: 426  TQRKLEQLRAELDEMYGQQIVQMKQE--LIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
              R + QL  E   + G+Q  Q +QE  + R+   ++EE++   +               
Sbjct: 756  -NRLVAQLEEEKSALQGRQR-QAEQEATVAREEQERLEELRLEQE--------------- 798

Query: 484  NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
                     VA   L   L+     +E L+++L  +  E+  LQ QL  L  +LS   ++
Sbjct: 799  ---------VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849

Query: 544  IQRARQTIAEQESKLNEAHKSLSTVED----LKAEIVSA-------SESRKELELKHEA- 591
            +++AR+    Q   L  A +    +      L  ++V+A       SE    L L+ EA 
Sbjct: 850  LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 909

Query: 592  ---------EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKE 642
                     ++   + + E LE E  A+L    E+   EL  LR Q++ + E+  + L +
Sbjct: 910  EGSLFEVQRQLAQLEARREQLEAEGQALL-LAKETLTGELAGLRQQIIATQEK--ASLDK 966

Query: 643  DLEIEHRINIEK-----LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
            +L  +  +  E+     L++    H ++ +  LQ E       ++ E+  L   Q+QL  
Sbjct: 967  ELMAQKLVQAEREAQASLREQRAAH-EEDLQRLQREKEAAWRELEAERAQL---QSQLQR 1022

Query: 698  EISKLKDLQQSLVNSKSEEMTLQINELQKEIE---ILRQEEKEKGTLEQEVQELQLKTEL 754
            E  +L     + + ++ EE++ +I  LQ+E +   +L + EK++    +E ++  L  +L
Sbjct: 1023 EQEELL----ARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 1078

Query: 755  L-------------EKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801
            +             E+Q ++ ++  ++  + + A  S L+D +   E+    H   +QE 
Sbjct: 1079 MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH---AQEV 1135

Query: 802  RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
            R      ++ +++D    K+ +  + E E+L+ Q   L +  +  R     A++      
Sbjct: 1136 R-----RLQEQARDL--GKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKL---- 1184

Query: 862  QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921
            +E QE      +   +L  S  +   E +  L+  NEEL        + ++   + +EDK
Sbjct: 1185 RESQEGREVQRQEAGELRRSLGEGAKE-REALRRSNEELRSAVKKAESERISLKLANEDK 1243

Query: 922  TFVAETLEMGEV-VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980
                  LE     V K+  EL   L+  +R +LE  + L +L  Q+K    E + L  E+
Sbjct: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303

Query: 981  KSLK 984
              L+
Sbjct: 1304 AELQ 1307



 Score =  116 bits (290), Expect = 5e-25
 Identities = 397/1955 (20%), Positives = 784/1955 (40%), Gaps = 289/1955 (14%)

Query: 1988 GPVEQQLLQETEKLMKEKLE--VQCQAEKV--RDDLQK-QVKALEIDVEEQVSRFIE--- 2039
            G    Q ++ T + + + LE  V CQ + +  RD  Q  Q+ +L   + E V+R +    
Sbjct: 4    GLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPE 63

Query: 2040 ----LEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
                L   +   L+ L+++NQ L+++L ++   L +   +R+     +    ++LEQ L+
Sbjct: 64   SPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALR 123

Query: 2096 VVPRFQPISEHQ--TREVEQLANHLKEKTDKCSELLLSKEQLQRD----IQERNEEIEKL 2149
            + P      E +   R+  +L   L+E+       L + ++ Q+     +Q    +I + 
Sbjct: 124  LEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY 183

Query: 2150 EFRVRELEQALLVSADTF--QKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITN 2207
            + R  ELEQ LL  +     Q++ D +H   +E     S  ++L+ E+       +    
Sbjct: 184  KKRCSELEQQLLERSGELEQQRLRDTEHSQDLE-----SALIRLEEEQQRSASLAQVNAM 238

Query: 2208 LEEQLEQFREELENKNEEVQQL-----HMQLEIQKKESTTRLQELEQENKLFKDDMEKLG 2262
            L EQL+Q     +  +E+++++       + E++ +E+  R +E E  N  F ++  +L 
Sbjct: 239  LREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE-ESFNAYFSNEHSRLL 297

Query: 2263 L----------AIKESDAMSTQDQHVLFGKFA---QIIQE-----------KEVEIDQLN 2298
            L           + E    + +D   L G+ A   + +QE            E   +   
Sbjct: 298  LLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAAL 357

Query: 2299 EQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2358
            E+   LQ QL+    +KV+ EK+   + +++ ++         K +    + +L   +++
Sbjct: 358  EKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLD---------KADLSARVTELGLAVKR 408

Query: 2359 LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2418
            L+++  N+ +K  +N   L+E+ ++L         E L L++Q     E+   ++  L  
Sbjct: 409  LEKQ--NL-EKDQVN-KDLTEKLEAL---------ESLRLQEQAALETEDGEGLQQTL-- 453

Query: 2419 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2478
                              R+  + + S  E+ V ++    + D        +  +L+ L 
Sbjct: 454  ------------------RDLAQAVLSDSESGVQLSGSERTAD-------ASNGSLRGLS 488

Query: 2479 NQTYFKSFEENGKG---SIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEM 2535
             Q        +  G   S     +      ST++     L +   Q++DM  +G++E   
Sbjct: 489  GQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDM--RGRYEAS- 545

Query: 2536 LQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED 2595
             Q  +  L+K + +  +     + QL+ +++      D    + E  +  +Q L    E 
Sbjct: 546  -QDLLGTLRKQLSDSESERRALEEQLQRLRDKT----DGAMQAHEDAQREVQRLRSANE- 599

Query: 2596 ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE---------- 2645
             L  + S L   +   + Q  E+      E+E+++ A++ +  +  +L E          
Sbjct: 600  LLSREKSNLAHSLQVAQQQAEELRQ----EREKLQAAQEELRRQRDRLEEEQEDAVQDGA 655

Query: 2646 -LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEA------LRAES 2698
             +++ LE + ++  + E KRS    E+++    L  +  +       +A       +AE+
Sbjct: 656  RVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEA 715

Query: 2699 VATKAELASYKEKAEK--LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2756
               + EL+  K +AE+  LQ+ L        SL +D   +   +A+ +E+ S L+     
Sbjct: 716  GRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQ 775

Query: 2757 EVQESKKACMFEPL--PIKLSKSIASQ-TDGTLKISSSNQTPQILVKNAGIQINLQSECS 2813
              QE+  A   +     ++L + +A Q  +G+L++  + Q  + L +      + +S+  
Sbjct: 776  AEQEATVAREEQERLEELRLEQEVARQGLEGSLRV--AEQAQEALEQQLPTLRHERSQL- 832

Query: 2814 SEEVTEIISQFTEKIEKMQEL--HAAEILDMESRHISETETLKREHY-VAVQL------- 2863
             E++ ++  Q + + +++++    A   ++   R   E E L +EH  +AVQL       
Sbjct: 833  QEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREG 892

Query: 2864 --LKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF 2921
              L EE   L+   + L         +LA  +A   RE   ++     GQ + L      
Sbjct: 893  RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEA--RREQLEAE-----GQALLLAKE--- 942

Query: 2922 DIASEGRG-EESESATDSFPKKIKGLL--RAVHNEGMQVLSLTESPYSDGED-HSIQQVS 2977
             +  E  G  +   AT       K L+  + V  E     SL E   +  ED   +Q+  
Sbjct: 943  TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK 1002

Query: 2978 E-PWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLE 3036
            E  W E         S L+    ++  + EAE  + S+   +    R E LL  +     
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE----S 1058

Query: 3037 ERSVLLAAFRTELTAL-----GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLL 3091
            E+   L+   +E TAL     GT  ++  ++ LE   Q++  + +   +   ++   +L 
Sbjct: 1059 EKQQALSLKESEKTALSEKLMGTRHSLATIS-LEMERQKRDAQSRQEQD---RSTVNALT 1114

Query: 3092 SEIQALHAQ------MNGRKITLKREQESEKPSQE---LLEYNIQQKQSQMLE-----MQ 3137
            SE++ L AQ       + +++   +EQ  +   Q    L E    + Q ++LE     ++
Sbjct: 1115 SELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLR 1174

Query: 3138 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK---HLKELEAFRL 3194
             EL   + +  E QE    ++    EL+  L +   E E   ++  +    +K+ E+ R+
Sbjct: 1175 RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI 1234

Query: 3195 EVK----DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLE 3250
             +K    DK  ++ LL +   +  K++ EL+  L+    ++ RS    + EL++L+  ++
Sbjct: 1235 SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ----EVERSRLEARRELQELRRQMK 1290

Query: 3251 SQKQRNLQLNL-LLEQQKQLLNESQQKIESQRM---LYDAQLSEEQGRNLELQVLLESEK 3306
                 N +L   L E Q +L    + + ES+R    L    L  E    +  Q L  +++
Sbjct: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR 1350

Query: 3307 VRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK---------ELQKQLEEKHS 3357
                +      RER L   L+ + GT + +        LK         EL  +L     
Sbjct: 1351 KLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG 1410

Query: 3358 RIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL---------------QTEQEANTEGQ 3402
            R   L  E  + ++       Q+   R   R+ L                  ++A  EG 
Sbjct: 1411 RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGS 1470

Query: 3403 KKMHELQSKVE---DLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI 3459
             +     S +E     Q             DL+ + ++G ++EF ++    + +R+  R 
Sbjct: 1471 GEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRT 1530

Query: 3460 LYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM----- 3514
                LN      + ++R       ++++    ES  A+   ++G  +G   EL +     
Sbjct: 1531 QTSALNRQLA-EMEAERDSATSRARQLQKAVAESEEARR-SVDGRLSGVQAELALQEESV 1588

Query: 3515 ----------------IRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENID--- 3555
                            + + LQ   S+L+   +K S+    ET  + D   ++E +D   
Sbjct: 1589 RRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASE 1648

Query: 3556 ----EIILQLQKLTGQ-QGEEPSLVSPSTSCGSLTER---LLRQ--NAELTGHISQLTEE 3605
                ++ LQ + L G+ Q     L        +L +R   L RQ  ++E+     QLT E
Sbjct: 1649 SRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVE 1708

Query: 3606 KNDLRNMVMKLEEQIRWYRQTGAGRDNS---SRFSLNGGANIEAIIASEKEVWNREKLTL 3662
            +  L   + K+EE     R    G   +   S  SLN   +    +         ++  L
Sbjct: 1709 R--LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL 1766

Query: 3663 QKSL---KRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQK 3719
            Q+ L   ++A +E  K  + L     +QTL  +   + L+R+  +  + +  R+ L  ++
Sbjct: 1767 QERLDAARQALSEARKQSSSLGEQ--VQTLRGEVADLELQRVEAEG-QLQQLREVLRQRQ 1823

Query: 3720 KYLLLLLGGFQECEDATLALLARMGG-QPAFTDLE 3753
            +     L   Q+ +D    L  R+G  Q A   LE
Sbjct: 1824 EGEAAALNTVQKLQDERRLLQERLGSLQRALAQLE 1858



 Score =  113 bits (283), Expect = 3e-24
 Identities = 293/1529 (19%), Positives = 623/1529 (40%), Gaps = 179/1529 (11%)

Query: 1335 KLEEQVQEL-------ESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVD 1387
            K + QVQ++       + L+ +L++QL ++E    +E   L+++LQ + + T       D
Sbjct: 530  KRQLQVQDMRGRYEASQDLLGTLRKQLSDSE----SERRALEEQLQRLRDKT-------D 578

Query: 1388 SVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLE--KQYQEQLEEEVA 1445
              +    DAQR +             +  + E   +E++N+   L+  +Q  E+L +E  
Sbjct: 579  GAMQAHEDAQREVQ-----------RLRSANELLSREKSNLAHSLQVAQQQAEELRQERE 627

Query: 1446 KVIVSMSIAFAQQTELSR-----ISGGKENTASSKQAHAVCQQEQ--------------H 1486
            K+  +      Q+  L       +  G       +++H   +Q +               
Sbjct: 628  KLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVRE 687

Query: 1487 YFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL 1546
              +   L +D +  +  E  +   K E   +  EL      +    ++   + +S   + 
Sbjct: 688  ALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELS-----MTKLRAEEASLQDSLSKLS 742

Query: 1547 TISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE--------EQLEDMR--QELVR 1596
             ++E + ++DK  + R     E   S++   ++    E        E+LE++R  QE+ R
Sbjct: 743  ALNESL-AQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR 801

Query: 1597 QYQEHQ-QATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
            Q  E   +  E  ++A  +Q+   R ++ QLQE++ +L+RQL+ R     E  + +  R 
Sbjct: 802  QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGR-----EQELEQARRE 856

Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQ-NGNENQGEVEEQTFKEKELDRKPEDVPP 1714
               ++EAL++   A REK      ++    Q    E +G    +      L++  E +  
Sbjct: 857  AQRQVEALER---AAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEK--EALEG 911

Query: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774
             +   +R   Q    R  + L    +     +ET+   + G+  +   +Q  ASL     
Sbjct: 912  SLFEVQRQLAQLEARR--EQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 969

Query: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR-SGFAGT 1833
            A+  V++    + +     +        + R     W ++  E  +L  +L R       
Sbjct: 970  AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA 1029

Query: 1834 EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-ATES 1892
             ++ E EEL   I++  Q   E LL A SE    L   +  +T L  +    +   AT S
Sbjct: 1030 RLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS 1089

Query: 1893 LKCQEELRE---RLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLE 1949
            L+ + + R+   R  ++      L  EL       +  A       R++QE+   + +  
Sbjct: 1090 LEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQR 1149

Query: 1950 QELLCASNRLQELEAEQQQIQE-----ERELLSRQKEAMKAEAG-PVEQQLLQETEKLMK 2003
               L      +EL  + + +++      RELL  Q++  +++ G  V++Q   E  + + 
Sbjct: 1150 DSCL---REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLG 1206

Query: 2004 EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063
            E  + +    +  ++L+  VK  E    E++S  +   ++K  +L  L +   A+ K+  
Sbjct: 1207 EGAKEREALRRSNEELRSAVKKAE---SERISLKL-ANEDKEQKLALLEEARTAVGKEAG 1262

Query: 2064 KMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL----- 2118
            ++R  L E     E  R   ++E+Q+L +Q+K++      +    RE+ +L   L     
Sbjct: 1263 ELRTGLQEV----ERSRLEARRELQELRRQMKML---DSENTRLGRELAELQGRLALGER 1315

Query: 2119 KEKTDKCSELLL---------SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQK 2169
             EK  +   L L         S E +++++Q    ++++ E   R  E+ LL S +  + 
Sbjct: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARG 1375

Query: 2170 VEDRK--HFGAVEAKPELS------LEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2221
             E ++  H   +E K E +      L ++L A        E E+  +E Q      +L  
Sbjct: 1376 TEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG 1435

Query: 2222 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 2281
                   L   L + +  S           +    +    GL    +   S   Q    G
Sbjct: 1436 LR---SALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492

Query: 2282 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 2341
              A      +++ + +   + +  Q+L+         E++EL R   + +   +++ E  
Sbjct: 1493 P-ATSPASPDLDPEAVRGALREFLQELR-----SAQRERDEL-RTQTSALNRQLAEMEAE 1545

Query: 2342 KRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQ 2401
            + +      QL + + + ++   ++  + S     L+ + +S++        E+ A   Q
Sbjct: 1546 RDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS----ERERRATLDQ 1601

Query: 2402 VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2461
            V T    +   ++ L+ +  K++++      L+ ++  ++++    E+        L   
Sbjct: 1602 VATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRT----VKLELQ 1657

Query: 2462 KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ 2521
            +  LE  L    L   + +   ++ ++     + +L+ ++   +S V A  L+LT   ++
Sbjct: 1658 RRSLEGELQRSRLGLSDREAQAQALQDR----VDSLQRQV--ADSEVKAGTLQLT--VER 1709

Query: 2522 IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2581
            +     + +     L+ K+  L + + +  A+   ++ +   +Q+    C+ ++ +  E 
Sbjct: 1710 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER 1769

Query: 2582 ERTNIQNLNQLRE--DELGSDISALTLRISELESQVVEMHTSL------ILEKEQVEIAE 2633
                 Q L++ R+    LG  +  L   +++LE Q VE    L      + ++++ E A 
Sbjct: 1770 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAA 1829

Query: 2634 KNVLEK---EKKLLE-----LQKLLEGNEKKQREKEKK--RSPQDVEVLKTT-----TEL 2678
             N ++K   E++LL+     LQ+ L   E ++RE E+   R  +D   L+ T      E 
Sbjct: 1830 LNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREK 1889

Query: 2679 FHSNEESGFFN-ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT--SLQKDLSQ 2735
              S+E++   + E   L       + ELA  + + ++L+ +++V E + +   L+ D  Q
Sbjct: 1890 LRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQ 1949

Query: 2736 VRDHLAEAKEKLSILEKEDETEVQESKKA 2764
             +  L +  E+L   + + E  ++  ++A
Sbjct: 1950 QQLELQQEVERLRSAQAQTERTLEARERA 1978



 Score =  110 bits (275), Expect = 3e-23
 Identities = 282/1401 (20%), Positives = 546/1401 (38%), Gaps = 149/1401 (10%)

Query: 31   SPSKKQKKKRKTSSSKHDVSA----HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRT 86
            SP + +  +R  S +  D S     H  L+  Q Q  +M      R E++     T+ + 
Sbjct: 500  SPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDM----RGRYEASQDLLGTLRKQ 555

Query: 87   LHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYS 146
            L   E  S  +    +L+     T     +  +    V R      LL  E+  +  ++S
Sbjct: 556  LSDSE--SERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNL--AHS 611

Query: 147  EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
             Q AQ     L     +L   Q E+      LEE +     +G +  +E E + +Q    
Sbjct: 612  LQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ---- 667

Query: 207  ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQA-----SETLRNSTHSSTAA 261
                   L+Q   ++    +E +E+ E   +  +Q   LQA     +E L  +       
Sbjct: 668  -------LEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL 720

Query: 262  DLLQAKQQI--LTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE-----MEQDK 314
            +L   K +    + Q  L +   L E   + K D    ++ L+E+    +      EQ+ 
Sbjct: 721  ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA 780

Query: 315  KVENSNKEEIQE----KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
             V    +E ++E    +E   + L   +   E+    L+ +L T      +LQEQ+ Q +
Sbjct: 781  TVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840

Query: 371  QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKL 430
            +++   + EL  ++++ ++  E +++     E L K  H     +    +R  +    + 
Sbjct: 841  RQLSGREQELEQARREAQRQVEALERAAREKEALAK-EHAGLAVQLVAAEREGRTLSEEA 899

Query: 431  EQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL 490
             +LR E + + G          +++ +AQ+E  + + + E +  L +   +T     ++ 
Sbjct: 900  TRLRLEKEALEGSLFE------VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953

Query: 491  MNVAINELNIKLQDTNSQK---------EKLKEELGLILEEKCALQRQLEDLVEELSFSR 541
              +A  E     ++  +QK           L+E+     E+   LQR+ E    EL   R
Sbjct: 954  QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013

Query: 542  EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
             Q+Q   Q   E+     EA K     E+L  EI +  + R E  L  E+E       L 
Sbjct: 1014 AQLQSQLQREQEELLARLEAEK-----EELSEEIAALQQERDEGLLLAESEKQQ---ALS 1065

Query: 602  MLEKEKNAVLDRMAESQEA------ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKL 655
            + E EK A+ +++  ++ +      E+ER +       E++ S +   L  E R ++   
Sbjct: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA-LTSELR-DLRAQ 1123

Query: 656  KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715
            ++     + Q++  LQ    ++   +  ++D+ + +  +L  ++  L+D +  L   +  
Sbjct: 1124 REEAAAAHAQEVRRLQ----EQARDLGKQRDSCLREAEELRTQLRLLEDARDGL-RRELL 1178

Query: 716  EMTLQINELQKEIEILRQE----EKEKGTLEQEVQELQLKTELLEKQMKEKEND-LQEKF 770
            E   ++ E Q+  E+ RQE     +  G   +E + L+   E L   +K+ E++ +  K 
Sbjct: 1179 EAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKL 1238

Query: 771  AQLEAENSI-LKDEKKTL--EDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIE 827
            A  + E  + L +E +T   ++  ++ T + + ER      ++++ +     +++++L  
Sbjct: 1239 ANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER----SRLEARRELQELRRQMKMLDS 1294

Query: 828  ENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK--- 884
            EN  L ++  +L   +         + +      Q L +  A L  ++ +L+ ++ K   
Sbjct: 1295 ENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354

Query: 885  QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEK 944
            QE E++++ + L   L   R             ++ +   A  LE+             K
Sbjct: 1355 QEGEFRTRERRLLGSLEEARGT-----------EKQQLDHARGLEL-------------K 1390

Query: 945  LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004
            LE  + E  EL  RLS    + +    E++    EV+    E +   LR   L   +   
Sbjct: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELA--RVEVQRRAAEAQLGGLR-SALRRGLGLG 1447

Query: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064
            RA +        S   D         AEGS   +N     E     +        +    
Sbjct: 1448 RAPSPAPRPVPGSPARDA-------PAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500

Query: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124
                + +   L    +E  LR+ Q  E D+L+ + + L    N    +MEA+R   +   
Sbjct: 1501 DLDPEAVRGALREFLQE--LRSAQ-RERDELRTQTSAL----NRQLAEMEAERDSATSRA 1553

Query: 1125 STHVDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKT-----QET 1177
                  V E  E  +  D  L  ++ EL   QEE ++  ++  +  L  + T     Q T
Sbjct: 1554 RQLQKAVAESEEARRSVDGRLSGVQAELAL-QEESVRRSERERRATLDQVATLERSLQAT 1612

Query: 1178 GDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN 1237
              E +     I K+ KA   +     + L  VL    +  +K E+     E       + 
Sbjct: 1613 ESELRASQEKISKM-KANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGE----LQR 1667

Query: 1238 EDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENL 1297
                L D   + Q  Q+ + +L  +V +   K   LQ  + ++ G      + E    + 
Sbjct: 1668 SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDK 1727

Query: 1298 PKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQ---L 1354
             +  TE L+  S   N       H  K  +  + ++  L+E++      +S  ++Q   L
Sbjct: 1728 VRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSL 1787

Query: 1355 KETEQNYEAEIHCLQ-KRLQA 1374
             E  Q    E+  L+ +R++A
Sbjct: 1788 GEQVQTLRGEVADLELQRVEA 1808



 Score =  100 bits (248), Expect = 4e-20
 Identities = 269/1416 (18%), Positives = 555/1416 (39%), Gaps = 177/1416 (12%)

Query: 190  LQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQ-SQKLQIQFQQLQAS 248
            L  LQE    ++Q    +  L A   Q+R E+DE   ++  ++E+  Q L+++  +L+  
Sbjct: 76   LLSLQEENQLLQQELSRVEDLLA---QSRAERDELAIKYNAVSERLEQALRLEPGELETQ 132

Query: 249  ETLRNSTHSSTAADLLQAKQ-----QILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQE 303
            E       S      LQ +Q     ++  +Q+  + Q  L++  Q K   +  + S L++
Sbjct: 133  EPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQ 192

Query: 304  KI--KVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361
            ++  +  E+EQ +  +  + ++++     +EE   +     +    L+++L  A      
Sbjct: 193  QLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQA 252

Query: 362  LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421
            L E I +   +    + EL + +   R+  E                 +       +V  
Sbjct: 253  LSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSE 312

Query: 422  MEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNI 481
            ++  T+R L QL  EL      +  +  QE        +   ++R +  +E      + +
Sbjct: 313  VKMFTERDLLQLGGEL-----ARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQL 367

Query: 482  TVNEDQIKLMNVAINELNIKLQDTNSQKEKLK-----EELGLILE-------EKCALQRQ 529
               E+Q++  +  + E ++  Q   S  +K        ELGL ++       EK  + + 
Sbjct: 368  ---EEQLR--DKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKD 422

Query: 530  LEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE-LK 588
            L + +E L   R Q Q A +T         +      T+ DL   ++S SES  +L   +
Sbjct: 423  LTEKLEALESLRLQEQAALET--------EDGEGLQQTLRDLAQAVLSDSESGVQLSGSE 474

Query: 589  HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL-----KED 643
              A+ +N  ++   L  ++     R +        R       S    L+ +     K  
Sbjct: 475  RTADASNGSLR--GLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQ 532

Query: 644  LEIEH-RINIEKLKDNLGIHYKQQIDGLQNE--MSQKIETMQFEKDNLITKQNQLILEIS 700
            L+++  R   E  +D LG   KQ  D       + ++++ ++ + D  +        E+ 
Sbjct: 533  LQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ 592

Query: 701  KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMK 760
            +L+   + L   KS  +   +   Q++ E LRQE ++   L+   +EL+ + + LE++ +
Sbjct: 593  RLRSANELLSREKSN-LAHSLQVAQQQAEELRQEREK---LQAAQEELRRQRDRLEEEQE 648

Query: 761  EKEND----------LQEKFAQLEAENSILKDE---------KKTLE-DMLKIH------ 794
            +   D             +  QLE + S+L  E         + TL+ DML+        
Sbjct: 649  DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAE 708

Query: 795  --TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNE---EIEKQRNT 849
              T        + L   K +++++  +  +  L   NE L Q  + LN    ++E++++ 
Sbjct: 709  ALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSA 768

Query: 850  FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTT 909
                ++  E      +EE   L +++  LE    +Q LE   ++    +E   Q++   T
Sbjct: 769  LQGRQRQAEQEATVAREEQERLEELR--LEQEVARQGLEGSLRVAEQAQEALEQQL--PT 824

Query: 910  VKMKSSVFDEDKTFVAETL----EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ 965
            ++ + S   E    ++  L    +  E   ++    +E LE   REK  L++  + L+ Q
Sbjct: 825  LRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ 884

Query: 966  LKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025
            L     E   L+EE   L+ EKE +     E++  +    A   Q  + +  +LL    T
Sbjct: 885  LVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQ-LEAEGQALLLAKET 943

Query: 1026 MTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLR 1085
            +T     G ++ + +       I  ++K S +   + ++  Q +           ++SLR
Sbjct: 944  LT-----GELAGLRQQI-----IATQEKASLDKELMAQKLVQAER--------EAQASLR 985

Query: 1086 ATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCS 1145
              + +  + LQ+    L+ E+     ++EA+R  L        +++   +E EK++    
Sbjct: 986  EQRAAHEEDLQR----LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEE---- 1037

Query: 1146 LKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQT 1205
            L EE+   Q+E+ + L      + Q +  +E+              + A+SE+      +
Sbjct: 1038 LSEEIAALQQERDEGLLLAESEKQQALSLKESE-------------KTALSEKLMGTRHS 1084

Query: 1206 LCSVLGEYYTPALKCEVNAE-DKENSGDYISENEDPELQ------DYRYEVQDFQENMHT 1258
            L ++  E        +   E D+       SE  D   Q       +  EV+  QE    
Sbjct: 1085 LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARD 1144

Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-ENLPKEETEFLSIHSQMTNLEDI 1317
            L  +      +   L+T+L ++     DG++ E  E +   +E  E   +  Q       
Sbjct: 1145 LGKQRDSCLREAEELRTQL-RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203

Query: 1318 DVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQ---LKETEQNYEAEIHCLQKRLQA 1374
             +   +K       E+  L    +EL S +   + +   LK   ++ E ++  L++   A
Sbjct: 1204 SLGEGAK-------EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTA 1256

Query: 1375 VSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEK 1434
            V +        +  V  +  +A+R +                      +E    +K+L+ 
Sbjct: 1257 VGKEAGELRTGLQEVERSRLEARREL----------------------QELRRQMKMLDS 1294

Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494
            +   +L  E+A++   +++    + E  R + G        +A     +++    + KL 
Sbjct: 1295 E-NTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQ 1353

Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILL 1530
            + +  F+T E   +   EE +   K+  +H + + L
Sbjct: 1354 EQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLEL 1389



 Score = 90.9 bits (224), Expect = 2e-17
 Identities = 208/1106 (18%), Positives = 450/1106 (40%), Gaps = 137/1106 (12%)

Query: 158  EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQ-EFEAAIKQRDGIITQLTANLQQ 216
            E+M  +L   + E +     L E R  +  E LQ+LQ E EAA ++ +    QL + LQ+
Sbjct: 967  ELMAQKLVQAEREAQA---SLREQRAAH-EEDLQRLQREKEAAWRELEAERAQLQSQLQR 1022

Query: 217  ARRE--------KDETMREFLELT-EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK 267
             + E        K+E   E   L  E+ + L +   + Q + +L+ S  ++ +  L+  +
Sbjct: 1023 EQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTR 1082

Query: 268  QQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----------KKVE 317
              + T   ++E Q     D Q ++E     ++ L  +++    +++          ++++
Sbjct: 1083 HSLATISLEMERQKR---DAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQ 1139

Query: 318  NSNKEEIQEKETII---EELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK 374
               ++  +++++ +   EEL T++   E     L+ +L  A + L E QE    + QE  
Sbjct: 1140 EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199

Query: 375  NMKLEL-TNSKQKE--RQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQR 428
             ++  L   +K++E  R+S+EE++  +   E  +   K  ++D + +  +++       +
Sbjct: 1200 ELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK 1259

Query: 429  KLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQMEEMKTRHKGEM----------ENALR 476
            +  +LR  L E+   ++ + ++EL  +R+ M  ++   TR   E+          E A +
Sbjct: 1260 EAGELRTGLQEVERSRL-EARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEK 1318

Query: 477  SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE 536
                 T+   Q  L   A   L +  Q+    + KL+E+ G   E +   +R L  L E 
Sbjct: 1319 ESRRETLGLRQRLLKGEA--SLEVMRQELQVAQRKLQEQEG---EFRTRERRLLGSLEEA 1373

Query: 537  LSFSREQIQRARQTIAEQESKLNEAHK---SLSTVEDLKAEIVSASESRKELELKH-EAE 592
                ++Q+  AR    + E+   EA +    LS  E  +A+ + A  +R E++ +  EA+
Sbjct: 1374 RGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG-RAQGLEAELARVEVQRRAAEAQ 1432

Query: 593  VTNYKIKLEM------------LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640
            +   +  L                   +   D  AE     L    T       +  S  
Sbjct: 1433 LGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492

Query: 641  KEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNE----------MSQKIETMQFEKDNLIT 690
                     ++ E ++  L   + Q++   Q E          +++++  M+ E+D+  +
Sbjct: 1493 PATSPASPDLDPEAVRGALR-EFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATS 1551

Query: 691  KQNQLILEISKLKDLQQSL---VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747
            +  QL   +++ ++ ++S+   ++    E+ LQ      E  + R E + + TL+Q    
Sbjct: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQ------EESVRRSERERRATLDQ---- 1601

Query: 748  LQLKTELLEKQMKEKENDL---QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLI 804
                   LE+ ++  E++L   QEK ++++A  + L+ +K+ L+++L      + E R +
Sbjct: 1602 ----VATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLD-----ASESRTV 1652

Query: 805  FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
             L+  +   +  +    + +      D + Q   L + ++  +   + +E         +
Sbjct: 1653 KLELQRRSLEGELQRSRLGL-----SDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTV 1707

Query: 865  QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFV 924
            +     L KV++         E   + K++ L E L     +  + + K+    +  T  
Sbjct: 1708 ERLNGALAKVEES--------EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALT-- 1757

Query: 925  AETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984
                      E D   L E+L+  ++   E  ++ S L EQ++   GE++ L  +    +
Sbjct: 1758 --------ACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAE 1809

Query: 985  QEKEQVS--LRCRELEIIINHNRAENVQS----CDTQVSSLLDGVVTMTSRGAEGSVSKV 1038
             + +Q+   LR R+       N  + +Q        ++ SL   +  + +   E   S +
Sbjct: 1810 GQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSAL 1869

Query: 1039 NKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEN-DKLQK 1097
                   +     DKV  E +   E++ +       L      + L   +      +L+ 
Sbjct: 1870 RLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEA 1929

Query: 1098 ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK 1157
            ++ VL+   +  +L+++AQ+  L L       +  +       +A      + +   EE+
Sbjct: 1930 QVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQ 1989

Query: 1158 IKELQKIHQLELQTMKTQETGDEGKP 1183
            +  L+   Q EL+      +   G P
Sbjct: 1990 VSTLKGQLQQELRRSSAPFSPPSGPP 2015



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 204/1099 (18%), Positives = 443/1099 (40%), Gaps = 154/1099 (14%)

Query: 2    EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
            E E   ++LEA +A+L    QR+ +   +  ++ + +K + S     +    D  +  ++
Sbjct: 1001 EKEAAWRELEAERAQLQSQLQREQE---ELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057

Query: 62   CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
              +    S +  E T + E  +M T HS    S E       + +  +  +   S VN  
Sbjct: 1058 SEKQQALSLKESEKTALSEK-LMGTRHSLATISLEME---RQKRDAQSRQEQDRSTVNAL 1113

Query: 122  SFVMRT------------GKPTNLLREE--EFGVDDSYSEQGAQDSPTHLEMMESELAGK 167
            +  +R              +    L+E+  + G       + A++  T L ++E    G 
Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173

Query: 168  QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227
            + E+ E  R+L E +     EG +++Q  EA   +R        A  ++A R  +E +R 
Sbjct: 1174 RRELLEAQRKLRESQ-----EG-REVQRQEAGELRRS---LGEGAKEREALRRSNEELRS 1224

Query: 228  FLELTEQSQKLQIQF------QQLQASETLRNSTHSSTAADLLQAKQQI----LTHQQQL 277
             ++  E S+++ ++       Q+L   E  R +     A +L    Q++    L  +++L
Sbjct: 1225 AVKKAE-SERISLKLANEDKEQKLALLEEARTAV-GKEAGELRTGLQEVERSRLEARREL 1282

Query: 278  EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEM-EQDKKVENSN-KEEIQEKETIIEELN 335
            +E    ++    +      +++ LQ ++ + E  E++ + E    ++ + + E  +E + 
Sbjct: 1283 QELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMR 1342

Query: 336  TKIIEEEKKTLELKDKLTTADK-LLGELQEQIVQKNQEI---KNMKLELTNSKQKERQSS 391
             ++   ++K  E + +  T ++ LLG L+E    + Q++   + ++L+L  ++ +  +  
Sbjct: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELG 1402

Query: 392  EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDE------------ 439
              +    G  + L+      ++     VQR   E Q  L  LR+ L              
Sbjct: 1403 LRLSAAEGRAQGLE------AELARVEVQRRAAEAQ--LGGLRSALRRGLGLGRAPSPAP 1454

Query: 440  --MYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINE 497
              + G        E   + +     ++     +  +   + S  + + D  + +  A+ E
Sbjct: 1455 RPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDP-EAVRGALRE 1513

Query: 498  LNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK 557
               +L+    ++++L+ +         AL RQL ++  E   +  + ++ ++ +AE E  
Sbjct: 1514 FLQELRSAQRERDELRTQTS-------ALNRQLAEMEAERDSATSRARQLQKAVAESEEA 1566

Query: 558  LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAES 617
                   LS V+              EL L+ E+        +   E+E+ A LD++A +
Sbjct: 1567 RRSVDGRLSGVQ-------------AELALQEES--------VRRSERERRATLDQVA-T 1604

Query: 618  QEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQK 677
             E  L+   ++L  S +E++SK+K +                    + +++G +  + + 
Sbjct: 1605 LERSLQATESELRAS-QEKISKMKAN--------------------ETKLEGDKRRLKEV 1643

Query: 678  IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE 737
            ++  +     L  ++  L  E+ + + L  S   ++++ +  +++ LQ+++      E +
Sbjct: 1644 LDASESRTVKLELQRRSLEGELQRSR-LGLSDREAQAQALQDRVDSLQRQV---ADSEVK 1699

Query: 738  KGTLEQEVQELQ---LKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI- 793
             GTL+  V+ L     K E  E  +++K   L E  AQ  A  +  +D+   L+  L   
Sbjct: 1700 AGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTAC 1759

Query: 794  -HTPVSQEERLIFLDSIKSKSK--DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTF 850
             H     +ERL       S+++   S   ++++ L  E  DL+ Q ++   ++++ R   
Sbjct: 1760 EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL 1819

Query: 851  SFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTV 910
                       ++ QE  A  L     L+D +       + +L +L   L         V
Sbjct: 1820 -----------RQRQEGEAAALNTVQKLQDERRL----LQERLGSLQRALAQLEAEKREV 1864

Query: 911  KMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKH 970
            +  +   ++D+  +  TL+    VE++     E       EK  L + L+    +L +  
Sbjct: 1865 ERSALRLEKDRVALRRTLDK---VEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921

Query: 971  GEISFLNEEVKSLKQEKE----QVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTM 1026
             +I  L  +V  L+Q       +V  + ++LE+     R  + Q+   +     +     
Sbjct: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981

Query: 1027 TSRGAEGSVSKVNKSFGEE 1045
              RG E  VS +     +E
Sbjct: 1982 RVRGLEEQVSTLKGQLQQE 2000



 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 97/474 (20%), Positives = 201/474 (42%), Gaps = 54/474 (11%)

Query: 3110 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA 3169
            +E  S +  ++ L         Q+ EM+ E  S   RA +LQ+ ++  +     +   L+
Sbjct: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS 1575

Query: 3170 QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA 3229
              + EL    ++  +  +E  A         D+V  L  +L + + + R  Q  + K KA
Sbjct: 1576 GVQAELALQEESVRRSERERRA-------TLDQVATLERSLQATESELRASQEKISKMKA 1628

Query: 3230 KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLS 3289
               + E  DK  L+++   L++ + R ++L L     +  L  S+  +  +    +AQ  
Sbjct: 1629 NETKLEG-DKRRLKEV---LDASESRTVKLELQRRSLEGELQRSRLGLSDR----EAQAQ 1680

Query: 3290 EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQ 3349
              Q R   LQ  +   +V+   +  T++R     A+++ S+G             L++  
Sbjct: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA------------LRDKV 1728

Query: 3350 KQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ 3409
            + L E  ++    LN T    L   +     E DRQV ++ L   ++A +E +K+   L 
Sbjct: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLG 1788

Query: 3410 SKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELER----EEKRESRRILYQNLN 3465
             +V+ L+ ++ +   Q  + + + Q+L+ ++++ Q+ E       ++ ++ RR+L + L 
Sbjct: 1789 EQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLG 1848

Query: 3466 ----------------EPTTWSLTSDRTRNWVLQQKIEGETKESN------YAKLIEMNG 3503
                            E +   L  DR        K+E E   S+       A+   ++ 
Sbjct: 1849 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDR 1908

Query: 3504 GGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEI 3557
              TG   EL   ++++Q + +++ VL Q  S   Q E    +  + +Q+ ++ +
Sbjct: 1909 TLTGAELELAEAQRQIQQLEAQVVVLEQSHSP-AQLEVDAQQQQLELQQEVERL 1961



 Score = 60.1 bits (144), Expect = 4e-08
 Identities = 87/498 (17%), Positives = 210/498 (42%), Gaps = 39/498 (7%)

Query: 5    ERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQC-- 62
            ER +      A   Q  + +A+ D  +   +Q +K    S +   S    L+  Q++   
Sbjct: 1524 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELAL 1583

Query: 63   -NEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
              E    S +   +T+   +T+ R+L +   T  E   S E  S++         +    
Sbjct: 1584 QEESVRRSERERRATLDQVATLERSLQA---TESELRASQEKISKMKANETKLEGDKRRL 1640

Query: 122  SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
              V+   +   +  E    +     E   Q S   L   E++    Q  ++ L R++ + 
Sbjct: 1641 KEVLDASESRTVKLE----LQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADS 1696

Query: 182  RVTYGTEGL--QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQ 239
             V  GT  L  ++L    A +++ +G +      L +A  +   ++       +++  LQ
Sbjct: 1697 EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNS---TRDKNLHLQ 1753

Query: 240  IQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQIS 299
                  +    +      +    L +A++Q  +  +Q++     + D + ++ +   Q+ 
Sbjct: 1754 KALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQ 1813

Query: 300  FLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEE-----------LNTKIIEEEKKTLEL 348
             L+E ++  + ++ +    +  +++Q++  +++E           L  +  E E+  L L
Sbjct: 1814 QLREVLR--QRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRL 1871

Query: 349  KDKLTTADKLLGELQEQIVQKNQEIKNMKLE-------LTNSKQKERQSSEEIKQLMGTV 401
            +       + L +++ + ++ +++   +  E       LT ++ +  ++  +I+QL   V
Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV 1931

Query: 402  EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQME 461
              L++ +H  +Q E D  Q+ + E Q+++E+LR+   +   ++ ++ ++   RQ +  +E
Sbjct: 1932 VVLEQ-SHSPAQLEVD-AQQQQLELQQEVERLRSA--QAQTERTLEARERAHRQRVRGLE 1987

Query: 462  EMKTRHKGEMENALRSYS 479
            E  +  KG+++  LR  S
Sbjct: 1988 EQVSTLKGQLQQELRRSS 2005



 Score = 33.1 bits (74), Expect = 5.6
 Identities = 83/422 (19%), Positives = 175/422 (41%), Gaps = 61/422 (14%)

Query: 1254 ENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQT--DGMKLEFGEENLPKEETEFLSIHSQM 1311
            + + TL   +    ++L   Q ++SK+   +T  +G K    +E L   E+  + +  Q 
Sbjct: 1600 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRL-KEVLDASESRTVKLELQR 1658

Query: 1312 TNLEDIDVNHKSKLSSLQDLEKTKL-----EEQVQELESLISSLQQQLKETE-------- 1358
             +LE              +L++++L     E Q Q L+  + SLQ+Q+ ++E        
Sbjct: 1659 RSLEG-------------ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL 1705

Query: 1359 ---------QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTM----YPGSC 1405
                        E     L+ +++ ++E+    S  ++S        Q+ +    +    
Sbjct: 1706 TVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQV 1765

Query: 1406 VKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465
            +++ +D   +   E   K+ +++ + ++    E  + E+ +V     +   ++    R  
Sbjct: 1766 LQERLDAARQALSE-ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE 1824

Query: 1466 GGKE--NTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGE 1523
            G     NT    Q      QE+    +  L+Q +   +  E   ++ +++   L + L +
Sbjct: 1825 GEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDK 1884

Query: 1524 HGKEILLSNSDPHDIPESK---DCVLTISEEMFSKDKTFIVRQSIHDEISV---SSMDAS 1577
              +E L S+ D   +   K   D  LT +E   ++ +  I  Q +  ++ V   S   A 
Sbjct: 1885 VEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQI--QQLEAQVVVLEQSHSPAQ 1942

Query: 1578 RQLMLNEEQLEDMRQEL--VRQYQEHQQATELLRQAHMRQMERQREDQ-----EQLQEEI 1630
             ++   ++QLE ++QE+  +R  Q   + T   R+   RQ  R  E+Q      QLQ+E+
Sbjct: 1943 LEVDAQQQQLE-LQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001

Query: 1631 KR 1632
            +R
Sbjct: 2002 RR 2003


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  167 bits (422), Expect = 2e-40
 Identities = 359/1713 (20%), Positives = 725/1713 (42%), Gaps = 282/1713 (16%)

Query: 173  ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELT 232
            EL +E+EE+R    TEG                II  LT  L     EK ET ++ L L 
Sbjct: 50   ELEKEIEELRSKPVTEG-------------TGDIIKALTERLDALLLEKAETEQQCLSLK 96

Query: 233  EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE-QDHLLEDYQKKK 291
            +++ K++   Q+++ S T     H        + +Q  + + +++E  ++ L+    K  
Sbjct: 97   KENIKMK---QEVEDSVTKMGDAHK-------ELEQSHINYVKEIENLKNELMAVRSKYS 146

Query: 292  EDFTMQISFLQEKIKV-YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE--------E 342
            ED       L+E +    E+ +  K +N++++ +++ +  IE++     E+        +
Sbjct: 147  EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206

Query: 343  KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVE 402
              T E K+ +T    ++ E   Q  QKN  I +++ EL   K   +   EE+K+LM  +E
Sbjct: 207  ATTDEKKETVTQLQNII-EANSQHYQKN--INSLQEELLQLKAIHQ---EEVKELMCQIE 260

Query: 403  ELQKRN----HKDSQFETDIVQRMEQETQRKLEQLRAELDEM-----YGQQIVQMKQELI 453
               K +    +K ++ + ++V++ E   +   ++   EL+ +        Q  Q+   L+
Sbjct: 261  ASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILL 320

Query: 454  RQH--MAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS---- 507
            +++  + Q+   K +H  +    L S  +I   +D++  MN    +L +  Q        
Sbjct: 321  QENTFVEQVVNEKVKHLEDTLKELESQHSIL--KDEVTYMNNLKLKLEMDAQHIKDEFFH 378

Query: 508  QKEKL----------KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE-- 555
            ++E L          KEE G ++E+   L+ +L  L ++  ++ EQ  R  Q++ EQ   
Sbjct: 379  EREDLEFKINELLLAKEEQGCVIEK---LKSELAGLNKQFCYTVEQHNREVQSLKEQHQK 435

Query: 556  --SKLNEAHKSLSTVEDLKA--EIVSASESRKELELKHEAEVTNYKIKLEMLE------- 604
              S+LNE   S S  E L    EI    E  + L+ + +  + NY+   E++E       
Sbjct: 436  EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 495

Query: 605  -------KEKNAVLDRMAESQEAELERLRT-------------QLLFSHEEELSKLKEDL 644
                   +E  ++  + A       ++LRT             +L   +E+ LS+ +   
Sbjct: 496  ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVP 555

Query: 645  EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITK------------- 691
            E+E+ I   + K+ + +    Q D +  E+  KI ++  EKD+ I K             
Sbjct: 556  ELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK 615

Query: 692  ----QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747
                + +LILE+ K K  Q    NS+ E+   ++NEL   +E   +  KEK   +Q++++
Sbjct: 616  KCEREERLILELGK-KVEQTIQYNSELEQ---KVNELTGGLE---ETLKEKDQNDQKLEK 668

Query: 748  LQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD 807
            L ++ ++L     E +  L  +   L  EN+ L  EKK L   L++   +SQ+E +I  +
Sbjct: 669  LMVQMKVL----SEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVF--LSQKEDVILKE 722

Query: 808  SIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEK---QRNTFSF------------ 852
             I      +  EK++++++EE ++L +  +  NE+++K   +   + F            
Sbjct: 723  HI------TQLEKKLQLMVEEQDNLNK--LLENEQVQKLFVKTQLYGFLKEMGSEVSEDS 774

Query: 853  AEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKM 912
             EK+     Q + E  A + + K +L   ++++ LE + ++K L EE  +Q       ++
Sbjct: 775  EEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQ-----CEEL 829

Query: 913  KSSV--FDEDKTFVAETLE----MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQL 966
            KS +  ++++K  + + LE      E ++ D  E+    E T+ E   L  ++ ++S+  
Sbjct: 830  KSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC 889

Query: 967  KQ----KHGEISFLNEEVKSLKQEKEQVSLRCRELE-IIINHNRAENVQSCDTQVSSL-- 1019
             +       E  F+ E  ++LK   EQ  LR R  E I++  + A++    +  +SS+  
Sbjct: 890  SKSEIHNEKEKCFIKEH-ENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKE 948

Query: 1020 LDGVVTMTSRGAEGSVSKVNKSFGEESKIMVE-DKVSFENMTVGEESKQEQLILDHLPSV 1078
            L+  +    +  +    K+NK      K   E D    E  TV EE +  +   D L S 
Sbjct: 949  LEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQL-SA 1007

Query: 1079 TKESSLRATQPSEN-----DKLQKELNVLKSEQN-------DLRLQMEAQRICLSLVYST 1126
            +    ++  +  +N     +K  ++L+V K   N       DL  Q+    +    + S 
Sbjct: 1008 SMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSD 1067

Query: 1127 HVD---QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKP 1183
            + D   ++     N K   +  L+ +   A  +K  E +K+ Q E +  +   T +E + 
Sbjct: 1068 NEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKL-QKEQKIKEHATTVNELEE 1126

Query: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE---NEDP 1240
            L + + K +K + +     +Q L  V  +     L   +   D E     +++   N++ 
Sbjct: 1127 LQVQLQKEKKQLQKT----MQELELVKKDAQQTTL-MNMEIADYERLMKELNQKLTNKNN 1181

Query: 1241 ELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKE 1300
            +++D   E++  ++   TL  ++T   + +   + + +KI             ++ L K 
Sbjct: 1182 KIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKI-------------KQLLVKT 1228

Query: 1301 ETEFLSIHSQMTNLEDIDVNHKSKL-SSLQDLEKTKLEEQVQELESLISSLQQQLKETEQ 1359
            + E        T+   +  + K +L +S Q +E  K+  Q+ E+ S    + + LK + +
Sbjct: 1229 KKELADSKQAETDHLILQASLKGELEASQQQVEVYKI--QLAEITSEKHKIHEHLKTSAE 1286

Query: 1360 NYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419
             ++  +   Q+R+ A+ E     +   +   +T       +   + +K+  + ++  +  
Sbjct: 1287 QHQRTLSAYQQRVTALQEEC--RAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAET 1344

Query: 1420 FGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTE---------------LSRI 1464
             G K+E   +++L  Q + +L++    + +++S     Q+E               +S+ 
Sbjct: 1345 EGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKE 1404

Query: 1465 SGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFK----PLSKE 1520
            +  +E   S +  + + + E         SQ+++   +F       +EE +     L ++
Sbjct: 1405 AELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQ 1464

Query: 1521 LGEHGKEIL-LSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDE----------- 1568
            L +   ++  L N      P S    L    E  + D   +   ++  E           
Sbjct: 1465 LSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTE 1524

Query: 1569 --ISVSSMDASRQLMLNEEQ---------LEDMRQELVRQYQEHQQATELLRQAHMRQME 1617
               S S+   S + +LN  +          E  ++ELV++     ++ + L    +R+ E
Sbjct: 1525 SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHL-NGLLRETE 1583

Query: 1618 RQR----EDQEQLQEEIKRLNRQLAQRSSIDN----ENLV---------SERERVLLEEL 1660
                   E  + L+ EI+RL R   +  S  N    +N++         SERER LL  +
Sbjct: 1584 ATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERER-LLPVI 1642

Query: 1661 EALKQLSLAGREKLCCELRNSSTQTQNGNENQG 1693
              + QLS   + KL    +    + +N + + G
Sbjct: 1643 NTMLQLSPEEKGKLAAVAQG---EEENASRSSG 1672



 Score =  166 bits (419), Expect = 5e-40
 Identities = 313/1523 (20%), Positives = 648/1523 (42%), Gaps = 201/1523 (13%)

Query: 1507 DVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIH 1566
            ++K K+E +    ++G+  KE+  S+ +     E+    L      +S+DK  + +Q   
Sbjct: 99   NIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQL-- 156

Query: 1567 DEISVSSMDASRQLML---NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ 1623
            +E   + ++ S QL     +E+ ++ +++E+ +     ++    L++      + ++E  
Sbjct: 157  EEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETV 216

Query: 1624 EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSST 1683
             QLQ  I+  N Q  Q+      N+ S     L EEL  LK +     ++L C++  S+ 
Sbjct: 217  TQLQNIIEA-NSQHYQK------NINS-----LQEELLQLKAIHQEEVKELMCQIEASAK 264

Query: 1684 QTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI-LSNERYALQKAN--NRLLKILLEVVK 1740
            + +       E++E   K+ E   K      E  L N R A   AN  N++  ILL+   
Sbjct: 265  EHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQ--- 321

Query: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEA--SVKSCVHEEHTRVTDESIPSY 1798
                VE+ +   V  + D   + +S  S++ + E     ++K  +  +   + DE     
Sbjct: 322  ENTFVEQVVNEKVKHLEDTLKELESQHSIL-KDEVTYMNNLKLKLEMDAQHIKDEFFHER 380

Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE------IDPENEELMLNISSRLQA 1852
               +   N++ +  +  E+G  + +  ++S  AG        ++  N E+  ++  + Q 
Sbjct: 381  EDLEFKINELLLAKE--EQGCVIEK--LKSELAGLNKQFCYTVEQHNREVQ-SLKEQHQK 435

Query: 1853 AVEKLLEAISETSSQLEHAKVTQTELMRESFRQ-KQEATESLKCQEELRERLHEESRARE 1911
             + +L E     S + +   + + + ++E     +QE  E++   E LRE +       E
Sbjct: 436  EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIM-------E 488

Query: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971
             L  EL ++ G I         FE   Q++   +  L+Q+L  A      L     ++Q 
Sbjct: 489  ILQTELGESAGKISQE------FESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQG 542

Query: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031
            E E L  Q+E +           L+ T K ++EK  V   +   RD + K+++     + 
Sbjct: 543  ENEKLLSQQELVPE---------LENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLT 593

Query: 2032 EQVSRFIELEQEKNTELMDLR---------------------QQNQALEKQLEKMRKFLD 2070
            E+   FI   +  + E+ +                       Q N  LE+++ ++   L+
Sbjct: 594  EEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE 653

Query: 2071 EQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLL 2130
            E       E+D   Q+++KL  Q+KV+          + + E L+  +K   ++ ++L  
Sbjct: 654  ETL----KEKDQNDQKLEKLMVQMKVL----------SEDKEVLSAEVKSLYEENNKLSS 699

Query: 2131 SKEQLQRDIQERNEEIEK--LEFRVRELE---QALLVSADTFQKVEDRKHFGAVEAKPEL 2185
             K+QL RD++    + E   L+  + +LE   Q ++   D   K+ + +    +  K +L
Sbjct: 700  EKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQL 759

Query: 2186 SLEVQLQAERDAIDRKEKEITNL----EEQLEQFREELEN----KNEEVQQLHMQLEIQK 2237
               ++      + D +EK++ N+     E L +  EE  N    ++E+V +L  +++  +
Sbjct: 760  YGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQ 819

Query: 2238 KESTTRLQEL-------EQENKLFKDDMEKLG----------LAIK---ESDAMSTQDQH 2277
            +ES  + +EL       EQE  L + ++E++           L +K   E   +  Q+  
Sbjct: 820  EESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLL 879

Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE---LIRDLETQIECL 2334
            +   + +Q   + E+  ++  +   K  + LK   + K + ++     L++D   +   +
Sbjct: 880  IQVEEVSQTCSKSEIH-NEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSV 938

Query: 2335 MSDQECVKRNREEEIEQLNEVIEKLQQELANI---GQKTSMNAHSLSEEADSLKHQLDVV 2391
             +D     +  EE+IE L +  ++ ++++  I     K      S  +E  ++K +L+ +
Sbjct: 939  KNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESL 998

Query: 2392 IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSV 2451
             +EK  L   +    +     KN+L E   +  QL  E          +E +     NS 
Sbjct: 999  RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNST 1058

Query: 2452 NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAK 2511
             +  + ++ D  +L   +  + L+S       +  E     ++++ E    +L+     K
Sbjct: 1059 -LQCETINSDNEDLLARI--ETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115

Query: 2512 DLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFC 2571
            +   T    +++++Q Q Q E + LQK +  L+ + ++     L++      + +Y +  
Sbjct: 1116 EHATT--VNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNM----EIADYERLM 1169

Query: 2572 QD-NQTISSEPERTNIQNLNQ------LREDELGSDISALTLRISELESQVVEMHTSLIL 2624
            ++ NQ ++++  +  I++L Q       +++ L  +I++L   + + E +  ++   L+ 
Sbjct: 1170 KELNQKLTNKNNK--IEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVK 1227

Query: 2625 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEV----------LKT 2674
             K+  E+A+    E +   L LQ  L+G  +  +++ +    Q  E+          LKT
Sbjct: 1228 TKK--ELADSKQAETDH--LILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKT 1283

Query: 2675 TTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLS 2734
            + E  H    S +   + AL+ E  A KAE A+   + E  +    V+  N+   QK+ S
Sbjct: 1284 SAEQ-HQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYK----VRVHNVLKQQKNKS 1338

Query: 2735 QVRDHLAEAK---EKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSS 2791
              +     AK   E L +L  + + ++Q+S+       L I +S+    Q++    +   
Sbjct: 1339 MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNN-----LQINVSELQTLQSEHDTLLERH 1393

Query: 2792 NQTPQILV-KNAGIQ---INLQSE--CSSEEVTEIISQFTEKIEKMQELHAAEILDMESR 2845
            N+  Q  V K A ++    ++QSE      E T+ +SQ T + E ++     ++  ++  
Sbjct: 1394 NKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEE 1453

Query: 2846 HISETETLKRE-HYVAVQL--LKEECGTLKAV-----IQCLRSKEGSSIPEL-------A 2890
            H    ETL+++   +  QL  LK E  T   V     ++ LR +  + +P L        
Sbjct: 1454 HRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE 1513

Query: 2891 HSDAYQTREICSSDSGSDWGQGI 2913
              +  +T +  S  S S + Q +
Sbjct: 1514 EGEGMETTDTESVSSASTYTQSL 1536



 Score =  162 bits (410), Expect = 6e-39
 Identities = 298/1334 (22%), Positives = 554/1334 (41%), Gaps = 209/1334 (15%)

Query: 92   ITSHEQGFSVE-LESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGA 150
            +   EQG  +E L+SE++            C  V +  +    L+E+        +E   
Sbjct: 392  LAKEEQGCVIEKLKSELA------GLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFL 445

Query: 151  QDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQL----------------Q 194
             DS      +  E+ G + + E L +E +E  + Y  E L+++                Q
Sbjct: 446  SDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNY--ESLREIMEILQTELGESAGKISQ 503

Query: 195  EFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNS 254
            EFE+  +Q+   + +L   L+ A  EKD  +     L  +++KL  Q + +   E    +
Sbjct: 504  EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKN 563

Query: 255  THSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK 314
                    LL   Q+       L+E +  +    ++K+DF  ++               +
Sbjct: 564  LQEKNGVYLLSLSQR----DTMLKELEGKINSLTEEKDDFINKLK-----------NSHE 608

Query: 315  KVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK 374
            +++N +K + + +E +I EL  K+ +  +   EL+ K+   ++L G L+E + +K+Q   
Sbjct: 609  EMDNFHK-KCEREERLILELGKKVEQTIQYNSELEQKV---NELTGGLEETLKEKDQ--N 662

Query: 375  NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLR 434
            + KLE    + K     +E+  L   V+ L + N+K S                + +QL 
Sbjct: 663  DQKLEKLMVQMKVLSEDKEV--LSAEVKSLYEENNKLSS---------------EKKQLS 705

Query: 435  AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA 494
             +L+    Q+    +  ++++H+ Q+E+       E +N  +   N  V +  +K     
Sbjct: 706  RDLEVFLSQK----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYG 761

Query: 495  -INELNIKLQDTNSQKEKLK------EELGLILEEKCALQRQLEDLVEELSFSREQIQRA 547
             + E+  ++ + + +K+ +       E L  I EEKC L  Q ++ V EL          
Sbjct: 762  FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLEL---------- 811

Query: 548  RQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEK 607
                 E+E K             L+ E V   E  K L   +E E    + +LE ++ EK
Sbjct: 812  -----EKEIKC------------LQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEK 854

Query: 608  NAVLDRMAESQEA-ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ 666
             A+   + E + A E  RL  Q L    EE+S+     EI +    EK K  +  H    
Sbjct: 855  EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHN----EKEKCFIKEH---- 906

Query: 667  IDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQK 726
             + L+  + QK          L  ++ +LIL    LKD      + K++ ++  + EL++
Sbjct: 907  -ENLKPLLEQK---------ELRDRRAELIL----LKDSLAKSPSVKNDPLS-SVKELEE 951

Query: 727  EIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKT 786
            +IE L +E KEK   E+++ +++L     +K++     + Q    +LE+    L+ EK  
Sbjct: 952  KIENLEKECKEK---EEKINKIKLVAVKAKKELDSSRKETQTVKEELES----LRSEKDQ 1004

Query: 787  LEDMLKIHTPVSQEERLIFLDSIK-------SKSKDSVWEKEIEILIEENEDLKQQCIQL 839
            L   ++     ++  + + L+  K        K + + +E  IE L  +  +   QC  +
Sbjct: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064

Query: 840  ---NEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKAL 896
               NE++  +  T     K  EV   E+Q   A    V  +LE  K ++E + K     +
Sbjct: 1065 NSDNEDLLARIETLQSNAKLLEVQILEVQRAKA---MVDKELEAEKLQKEQKIKEHATTV 1121

Query: 897  N--EELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTE-LMEKLEVTKREKL 953
            N  EEL +Q               ++K  + +T++  E+V+KD  +  +  +E+   E+L
Sbjct: 1122 NELEELQVQ-------------LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERL 1168

Query: 954  ELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCD 1013
                 + +L+++L  K+ +I  L +E+K  KQ++E +      L+  +     +N +   
Sbjct: 1169 -----MKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQ 1223

Query: 1014 TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILD 1073
              V +  +      S+ AE     +  S   E +   + +V    + + E + ++  I +
Sbjct: 1224 LLVKTKKE---LADSKQAETDHLILQASLKGELEAS-QQQVEVYKIQLAEITSEKHKIHE 1279

Query: 1074 HL-PSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVR 1132
            HL  S  +     +        LQ+E    K+EQ  +  + E+ ++ +  V     ++  
Sbjct: 1280 HLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSM 1339

Query: 1133 EYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQ 1192
               E E  K      E LI   + K+++ Q   Q+ +  ++T ++ +    L      LQ
Sbjct: 1340 SQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQS-EHDTLLERHNKMLQ 1398

Query: 1193 KAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDF 1252
            + VS+E     + LCS+  E         + +E  +      S+NE      +R +V+  
Sbjct: 1399 ETVSKEAE-LREKLCSIQSE------NMMMKSEHTQTVSQLTSQNEVLR-NSFRDQVRHL 1450

Query: 1253 QE----NMHTLLNKVTEEYNKLLVLQ---TRLSKIWGQQ----------TD----GMKLE 1291
            QE     + TL  ++++   +L  L+   T  S +  QQ          TD     M   
Sbjct: 1451 QEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510

Query: 1292 FGEENLPKEETEFLSIHSQMT---NLEDIDVNHKSKLS-SLQDLEKTKLEEQVQELESLI 1347
              EE    E T+  S+ S  T   +LE +  + ++KL   L   E TK EE VQ+L S  
Sbjct: 1511 TREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTK-EELVQKLSSTT 1569

Query: 1348 SS---LQQQLKETE 1358
             S   L   L+ETE
Sbjct: 1570 KSADHLNGLLRETE 1583



 Score =  160 bits (406), Expect = 2e-38
 Identities = 358/1793 (19%), Positives = 744/1793 (41%), Gaps = 246/1793 (13%)

Query: 203  RDGIITQLTANLQQARRE---KDETMREFLELTEQSQKLQIQFQQLQAS-ETLRNSTHSS 258
            +DG+ +  T    +++ E   K++ ++   +     QK + +  +L+   E LR+   + 
Sbjct: 6    QDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTE 65

Query: 259  TAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVEN 318
               D+++A  + L     LE+ +   +    KKE+  M+        K+ +    K++E 
Sbjct: 66   GTGDIIKALTERLD-ALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAH--KELEQ 122

Query: 319  SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL 378
            S+   ++E E +  EL     +  +    L+ +L  A     EL EQ+  +N    N+K 
Sbjct: 123  SHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVK- 181

Query: 379  ELTNSKQKERQSSEE-----IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQL 433
            +L    +K R   EE      KQL  T +E   +    +Q + +I++   Q  Q+ +  L
Sbjct: 182  KLQEEIEKIRPGFEEQILYLQKQLDATTDE---KKETVTQLQ-NIIEANSQHYQKNINSL 237

Query: 434  RAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV 493
            + EL      Q+  + QE +++ M Q+E     H+ E+ N L       V + +    N+
Sbjct: 238  QEEL-----LQLKAIHQEEVKELMCQIEASAKEHEAEI-NKLNELKENLVKQCEASEKNI 291

Query: 494  AINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAE 553
               +   +L++         ++      + C++  Q    VE++    E+++    T+ E
Sbjct: 292  Q-KKYECELENLRKATSNANQD-----NQICSILLQENTFVEQV--VNEKVKHLEDTLKE 343

Query: 554  QESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDR 613
             ES+ +     ++ + +LK ++   ++  K+ E  HE E   +KI   +L KE+   +  
Sbjct: 344  LESQHSILKDEVTYMNNLKLKLEMDAQHIKD-EFFHEREDLEFKINELLLAKEEQGCVIE 402

Query: 614  MAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDN-LGIHYKQQIDGLQN 672
              +S+ A L +     +  H  E+  LKE    +H+  I +L +  L    K+++     
Sbjct: 403  KLKSELAGLNKQFCYTVEQHNREVQSLKE----QHQKEISELNETFLSDSEKEKL----- 453

Query: 673  EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR 732
             +  +I+ ++ + +NL  ++ + IL    L+++ + L      E+     ++ +E E ++
Sbjct: 454  TLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEIL----QTELGESAGKISQEFESMK 509

Query: 733  QEEKEKGTLEQEVQELQ--LKTELLEKQ-MKEKENDLQEKFAQLEAENSILKDEKKTLED 789
            Q++        +V ELQ  L+T   EK  + E  N LQ +  +L ++  ++ + + T+++
Sbjct: 510  QQQ------ASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKN 563

Query: 790  MLKIHTPVSQEERLIFLDSIKSK-SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRN 848
            +        QE+  ++L S+  + +     E +I  L EE +D   +    +EE++   N
Sbjct: 564  L--------QEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD---N 612

Query: 849  TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
                 E+  E    EL ++    ++   +LE   N+     +  LK   ++ + Q++   
Sbjct: 613  FHKKCERE-ERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLK--EKDQNDQKLEKL 669

Query: 909  TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS-DLSEQLK 967
             V+MK  V  EDK  +  + E+  + E++     EK ++++  ++ LSQ+    L E + 
Sbjct: 670  MVQMK--VLSEDKEVL--SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHIT 725

Query: 968  QKHGEISFLNEEVKSLKQ--EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025
            Q   ++  + EE  +L +  E EQV     + ++        +  S D++   +++ +  
Sbjct: 726  QLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQA 785

Query: 1026 MTSRGAEGSVSKVNKSFGEESKIMVEDK----VSFENMTVGEESKQEQLILDH-LPSVTK 1080
            +    A+ +  K N +F  + K++  +K    +  E++   EE K   L+ D+    V  
Sbjct: 786  VGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELK--SLLRDYEQEKVLL 843

Query: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
               L   Q SE + LQ +L  +K+     RL+ +   I +  V  T     +  + NEK+
Sbjct: 844  RKELEEIQ-SEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQT---CSKSEIHNEKE 899

Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200
            K      E L    E+K    ++   + L+    +    +  PL   + +L++ +     
Sbjct: 900  KCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS-SVKELEEKIEN--- 955

Query: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260
              L+  C    E         V A+ + +S    ++    EL+  R E      +M  L+
Sbjct: 956  --LEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI 1013

Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
                   N LL  + +  ++  ++      E   E+L ++      + +     E I+ +
Sbjct: 1014 QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQ------LRNSTLQCETINSD 1067

Query: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380
            ++  L+ ++ L+      +VQ LE     +Q+     ++  EAE   LQK  +    +T 
Sbjct: 1068 NEDLLARIETLQSNAKLLEVQILE-----VQRAKAMVDKELEAE--KLQKEQKIKEHATT 1120

Query: 1381 PPSLPVDSVVI--TESDAQRTMYPGSCVKKNIDGTIEFSGEFG------------VKEET 1426
               L    V +   +   Q+TM     VKK+   T   + E              +  + 
Sbjct: 1121 VNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKN 1180

Query: 1427 NIVKLLE------KQYQEQLEEEVAKVIVSMSIAFAQQTELSR-ISGGKENTASSKQA-- 1477
            N ++ LE      KQ QE L+EE+  +  S+     + T++ + +   K+  A SKQA  
Sbjct: 1181 NKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAET 1240

Query: 1478 -HAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH 1536
             H + Q       E++ SQ Q+     +  ++  ++       ++ EH    L ++++ H
Sbjct: 1241 DHLILQASLK--GELEASQQQVEVYKIQLAEITSEKH------KIHEH----LKTSAEQH 1288

Query: 1537 D--IPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL 1594
               +   +  V  + EE          R +  ++ +V+S   S ++ ++           
Sbjct: 1289 QRTLSAYQQRVTALQEE---------CRAAKAEQATVTSEFESYKVRVHNVL-------- 1331

Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIK----------RLNRQLAQRSSID 1644
                   QQ  + + QA     +++RE  E L +++K          ++N    Q    +
Sbjct: 1332 ------KQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSE 1385

Query: 1645 NENLVSERERVLLEELEALKQLSLAGREKLC------CELRNSSTQTQNGNENQGEVEEQ 1698
            ++ L+    ++L E +    +L    REKLC        +++  TQT +   +Q EV   
Sbjct: 1386 HDTLLERHNKMLQETVSKEAEL----REKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRN 1441

Query: 1699 TFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILD 1758
            +F+++    + E          R  ++    +L K+  ++ +                L 
Sbjct: 1442 SFRDQVRHLQEE---------HRKTVETLQQQLSKMEAQLFQ----------------LK 1476

Query: 1759 RSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEG 1818
                ++S  S      ++ S+K+     +T             D+P  D++  ++   EG
Sbjct: 1477 NEPTTRSPVS------SQQSLKNLRERRNT-------------DLPLLDMHTVTREEGEG 1517

Query: 1819 TELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV-------EKLLEAISETSSQLEHA 1871
             E +     S  + +      E+L+ +  ++L+  +       E+L++ +S T+   +H 
Sbjct: 1518 METTD--TESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHL 1575

Query: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924
                  L+RE+        E +K  +    RL E ++ RE+ A  L   + V+
Sbjct: 1576 ----NGLLRETEATNAILMEQIKLLKSEIRRL-ERNQEREKSAANLEYLKNVL 1623



 Score =  159 bits (401), Expect = 7e-38
 Identities = 302/1582 (19%), Positives = 673/1582 (42%), Gaps = 170/1582 (10%)

Query: 2086 EIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145
            E++K  ++L+  P  +   +      E+L   L EK +   + L  K++  +  QE  + 
Sbjct: 50   ELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDS 109

Query: 2146 IEKLEFRVRELEQALLVSADTFQKVED-----RKHFGAVEAKPELSLEVQLQAERDAIDR 2200
            + K+    +ELEQ+ +      + +++     R  +   +A  +  LE  +  + +  ++
Sbjct: 110  VTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQ 169

Query: 2201 ------KEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI---QKKESTTRLQEL-EQE 2250
                   E  +  L+E++E+ R   E   E++  L  QL+    +KKE+ T+LQ + E  
Sbjct: 170  LKFQNNSEDNVKKLQEEIEKIRPGFE---EQILYLQKQLDATTDEKKETVTQLQNIIEAN 226

Query: 2251 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2310
            ++ ++ ++  L   + +  A+  ++   L  +     +E E EI++LNE    L +Q + 
Sbjct: 227  SQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEA 286

Query: 2311 TTDN--KVIEEKNELIR------DLETQI-ECLMSDQECVKRNREEEIEQLNEVIEKLQQ 2361
            +  N  K  E + E +R      + + QI   L+ +   V++   E+++ L + +++L+ 
Sbjct: 287  SEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELES 346

Query: 2362 E----------LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEM-T 2410
            +          + N+  K  M+A  + +E    +  L+  I E L  +++     E++ +
Sbjct: 347  QHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKS 406

Query: 2411 FMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2470
             +  + K+  + + Q  +E+ SLK + +  ++I  + E  ++        +K +L ++  
Sbjct: 407  ELAGLNKQFCYTVEQHNREVQSLKEQHQ--KEISELNETFLS------DSEKEKLTLMFE 458

Query: 2471 EDALKSLENQTYFKSFEENGKGSIINLET-----RLLQLESTVSAKDLELTQCYKQIKDM 2525
               LK        ++ ++  + +I+N E+      +LQ E   SA  +      ++ + M
Sbjct: 459  IQGLKE-----QCENLQQEKQEAILNYESLREIMEILQTELGESAGKIS-----QEFESM 508

Query: 2526 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE---AVQEYAKFCQDNQTISSEPE 2582
            ++Q   +   LQ+K+       E+      V+++Q E    + +     +   TI +  E
Sbjct: 509  KQQQASDVHELQQKLRTA--FTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQE 566

Query: 2583 RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKK 2642
            +  +  L+  + D +  ++     +I+ L  +  +    L    E+++   K    +E+ 
Sbjct: 567  KNGVYLLSLSQRDTMLKELEG---KINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERL 623

Query: 2643 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE-SGFFNELEALRAESVAT 2701
            +LEL K +E   +   E E+K +     + +T  E   ++++      +++ L  +    
Sbjct: 624  ILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVL 683

Query: 2702 KAELASYKEKAEKLQEEL--LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET--E 2757
             AE+ S  E+  KL  E   L ++  +   QK+   +++H+ + ++KL ++ +E +   +
Sbjct: 684  SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNK 743

Query: 2758 VQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEV 2817
            + E+++    + L +K      +Q  G LK   S  +     K+    +    E  ++  
Sbjct: 744  LLENEQV---QKLFVK------TQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKIN 794

Query: 2818 TEIISQFTEKIEKMQELHAAEILDMESRHISETETLK---REHYVAVQLLKEECGTLKAV 2874
             E  +   ++ EK+ EL   EI  ++   + + E LK   R++     LL++E   +++ 
Sbjct: 795  EEKCNLAFQRDEKVLELEK-EIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853

Query: 2875 IQCLRS-----KEGSSIPELAHSDAY----QTREICSSDSGSDWGQGIYLTHSQGFDIAS 2925
             + L+S     K  +    L + +      +  + CS     +  +  ++   +      
Sbjct: 854  KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913

Query: 2926 EGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERK 2985
            E +      A     K       +V N+ +  +   E    + E            +E++
Sbjct: 914  EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC---------KEKE 964

Query: 2986 AYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF--LEERSVLLA 3043
              IN I  +     K       E     +  ES    + +L  +++ +    E    LL 
Sbjct: 965  EKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLL 1024

Query: 3044 AFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQ-AAMECLQ-KADRRSLLSEIQALHAQM 3101
             +  +   L         N  E RI++   + + + ++C    +D   LL+ I+ L +  
Sbjct: 1025 EYEKQSEQLDVEKERA--NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNA 1082

Query: 3102 NGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV 3161
               ++ +   Q ++    + LE    QK+ ++ E    ++ ++    ELQ QL  EK   
Sbjct: 1083 KLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELE----ELQVQLQKEK--- 1135

Query: 3162 AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQ 3221
                 +L +T  ELE       K  ++     +E+ D    +  LN  L ++  K  +L+
Sbjct: 1136 ----KQLQKTMQELELV----KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187

Query: 3222 WALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQR 3281
              ++ +K K    +E  +EE+  L+ S++  +++N ++  LL + K+ L +S+Q  E+  
Sbjct: 1188 QEIKIQKQK----QETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQA-ETDH 1242

Query: 3282 MLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS 3341
            ++  A L  E   +   Q  +E  K+++ E++S    + ++H  L++S    Q R     
Sbjct: 1243 LILQASLKGELEAS---QQQVEVYKIQLAEITS---EKHKIHEHLKTSAEQHQ-RTLSAY 1295

Query: 3342 EDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG 3401
            +  +  LQ++     +    + +E E YK+      +Q +K++ + +   +  ++     
Sbjct: 1296 QQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQ-QKNKSMSQAETEGAKQEREHL 1354

Query: 3402 QKKMHELQSKVEDLQRQLEEKRQQVYKLDLEG----QRLQGIMQEFQKQELEREEKR--- 3454
            +  + +L+ K++D Q  L+    ++  L  E     +R   ++QE   +E E  EK    
Sbjct: 1355 EMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSI 1414

Query: 3455 ESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETK--ESNYAKLIEMNGGGTGCNHEL 3512
            +S  ++ ++ +  T   LTS   +N VL+     + +  +  + K +E            
Sbjct: 1415 QSENMMMKSEHTQTVSQLTS---QNEVLRNSFRDQVRHLQEEHRKTVET----------- 1460

Query: 3513 EMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE-- 3570
              ++Q+L  + ++L  L  + + R    +      +  + N D  +L +  +T ++GE  
Sbjct: 1461 --LQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGM 1518

Query: 3571 ----EPSLVSPSTSCGSLTERL 3588
                  S+ S ST   SL + L
Sbjct: 1519 ETTDTESVSSASTYTQSLEQLL 1540



 Score =  158 bits (400), Expect = 9e-38
 Identities = 329/1701 (19%), Positives = 701/1701 (41%), Gaps = 273/1701 (16%)

Query: 1139 KDKALCSLKEELIFAQEEKIK--ELQK-IHQLELQTMKTQETGDEGKPLHLLIGKL--QK 1193
            K+  +   K++++  Q+ K +  EL+K I +L  + + T+ TGD  K L   +  L  +K
Sbjct: 27   KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPV-TEGTGDIIKALTERLDALLLEK 85

Query: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENS-GDYISENEDPELQDYRYEVQDF 1252
            A +E+    L+             +K +   ED     GD   E E   + +Y  E+++ 
Sbjct: 86   AETEQQCLSLKK----------ENIKMKQEVEDSVTKMGDAHKELEQSHI-NYVKEIENL 134

Query: 1253 QENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTD-GMKLEF---GEENLPKEETEFLSIH 1308
            +  +  + +K +E+   L   Q +L +    Q +   +L+F    E+N+ K + E     
Sbjct: 135  KNELMAVRSKYSEDKANL---QKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEE----- 186

Query: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCL 1368
                 +E I    + ++  LQ     +L+    E +  ++ LQ  ++   Q+Y+  I+ L
Sbjct: 187  -----IEKIRPGFEEQILYLQK----QLDATTDEKKETVTQLQNIIEANSQHYQKNINSL 237

Query: 1369 QK---RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGE-FGVKE 1424
            Q+   +L+A+ +  V   +        E +A+      + +K+N+    E S +    K 
Sbjct: 238  QEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKL--NELKENLVKQCEASEKNIQKKY 295

Query: 1425 ETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQE 1484
            E  +  L +       + ++  +++  +  F +Q    ++   ++     +  H++ + E
Sbjct: 296  ECELENLRKATSNANQDNQICSILLQEN-TFVEQVVNEKVKHLEDTLKELESQHSILKDE 354

Query: 1485 QHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDC 1544
              Y N +KL          E      K+EF    ++L     E+LL+        E + C
Sbjct: 355  VTYMNNLKLK--------LEMDAQHIKDEFFHEREDLEFKINELLLAK-------EEQGC 399

Query: 1545 VLT-ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE------------------- 1584
            V+  +  E+   +K F      H+   V S+    Q  ++E                   
Sbjct: 400  VIEKLKSELAGLNKQFCYTVEQHNR-EVQSLKEQHQKEISELNETFLSDSEKEKLTLMFE 458

Query: 1585 --------EQLEDMRQELVRQYQEHQQATELLR-----------QAHMRQMERQREDQEQ 1625
                    E L+  +QE +  Y+  ++  E+L+           Q      ++Q  D  +
Sbjct: 459  IQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHE 518

Query: 1626 LQEEI------KRLNRQLAQRSSIDNENLVSERERVL--------LEELEALKQLSLAGR 1671
            LQ+++      K    +   R   +NE L+S++E V         L+E   +  LSL+ R
Sbjct: 519  LQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQR 578

Query: 1672 EKLCCELR---NSSTQTQNG--NENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK 1726
            + +  EL    NS T+ ++   N+ +   EE     K+ +R+ E +  E+       +Q 
Sbjct: 579  DTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE-ERLILELGKKVEQTIQY 637

Query: 1727 ANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE 1786
             N+ L +   +V + T  +EET+        ++    Q    L+ + +  +  K  +  E
Sbjct: 638  -NSELEQ---KVNELTGGLEETLK-------EKDQNDQKLEKLMVQMKVLSEDKEVLSAE 686

Query: 1787 HTRVTDESIPSYSGSDMPRNDINMWSKVTEEG------TELSQRLVRSGFAGTEIDP--E 1838
               + +E+    S       D+ ++    E+       T+L ++L         ++   E
Sbjct: 687  VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746

Query: 1839 NEELM-LNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ- 1896
            NE++  L + ++L   ++++   +SE S + +   V Q   + ES  +  E   +L  Q 
Sbjct: 747  NEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQA--VGESLAKINEEKCNLAFQR 804

Query: 1897 -EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
             E++ E   E    +E+  V+  + + ++  Y  EK L  ++++E     + L+ +LL  
Sbjct: 805  DEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEM 864

Query: 1956 SNRLQELEAEQQ----QIQEERELLSRQKEAMKAEAGPVEQQ-----LLQETEK------ 2000
             N  ++   E Q    Q++E  +  S+ +   + E   +++      LL++ E       
Sbjct: 865  KNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAE 924

Query: 2001 --LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNT----------EL 2048
              L+K+ L    ++  V++D    VK LE  +E       E E++ N           EL
Sbjct: 925  LILLKDSL---AKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKEL 981

Query: 2049 MDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQ---------EIQKLEQQLKVVPR 2099
               R++ Q ++++LE +R   D+ +      RD+ Q          E +K  +QL V   
Sbjct: 982  DSSRKETQTVKEELESLRSEKDQLSASM---RDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038

Query: 2100 FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA 2159
                 EH+   +E L   L+  T +C  +    E L   I+      + LE ++ E+++A
Sbjct: 1039 RANNFEHR---IEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRA 1095

Query: 2160 LLV-----SADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKE---------- 2204
              +      A+  QK +  K       + E  L+VQLQ E+  + +  +E          
Sbjct: 1096 KAMVDKELEAEKLQKEQKIKEHATTVNELE-ELQVQLQKEKKQLQKTMQELELVKKDAQQ 1154

Query: 2205 -------ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT----------RLQEL 2247
                   I + E  +++  ++L NKN +++ L  +++IQK++  T           +Q+ 
Sbjct: 1155 TTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQY 1214

Query: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQD---QHVLFGKFAQIIQEKEV---EIDQLNEQV 2301
            E++N   K  + K    + +S    T     Q  L G+     Q+ EV   ++ ++  + 
Sbjct: 1215 EEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEK 1274

Query: 2302 TKLQQQLKITTD--NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2359
             K+ + LK + +   + +    + +  L+ +     ++Q  V    E    +++ V++  
Sbjct: 1275 HKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLK-- 1332

Query: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET 2419
            QQ+  ++ Q  +  A    E  + L  QL + + +    +  ++    E+  +++     
Sbjct: 1333 QQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDS---QNNLQINVSELQTLQSEHDTL 1389

Query: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDH---LSKDKPELEVVLT--EDAL 2474
              + N++ QE  ++ +E E  EK+ SI   ++ +  +H   +S+   + EV+     D +
Sbjct: 1390 LERHNKMLQE--TVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV 1447

Query: 2475 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETE 2534
            + L+ +   +   E  +  +  +E +L QL++  + +    +Q  + +K+++E+   +  
Sbjct: 1448 RHLQEE--HRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ--QSLKNLRERRNTDLP 1503

Query: 2535 MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL--NQL 2592
            +L    V  ++          +     E+V   + + Q  + + + PE      L   + 
Sbjct: 1504 LLDMHTVTREE-------GEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEF 1556

Query: 2593 REDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG 2652
             ++EL   +S+ T     L   + E   +  +  EQ+++ +  +                
Sbjct: 1557 TKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEI---------------- 1600

Query: 2653 NEKKQREKEKKRSPQDVEVLK 2673
              + +R +E+++S  ++E LK
Sbjct: 1601 -RRLERNQEREKSAANLEYLK 1620



 Score =  147 bits (371), Expect = 2e-34
 Identities = 285/1401 (20%), Positives = 571/1401 (40%), Gaps = 256/1401 (18%)

Query: 134  LREEEFGVDDSYSEQGAQDSPTHLEMMESELA---------GKQHEIEELNRELEEMRVT 184
            L+ E   V   YSE  A       E M ++L            +  +++L  E+E++R  
Sbjct: 134  LKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPG 193

Query: 185  YGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQ 244
            +  + L   ++ +A   ++   +TQL  N+ +A                 SQ  Q     
Sbjct: 194  FEEQILYLQKQLDATTDEKKETVTQL-QNIIEA----------------NSQHYQKNINS 236

Query: 245  LQASETLRNSTHSSTAADLL-QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQE 303
            LQ       + H     +L+ Q +     H+ ++ + + L E+  K+ E     I     
Sbjct: 237  LQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQ---- 292

Query: 304  KIKVYEMEQD---KKVENSNKEE-----IQEKETIIEELNTKIIEEEKKTLELKDKLTTA 355
              K YE E +   K   N+N++      + ++ T +E+    ++ E+ K LE  D L   
Sbjct: 293  --KKYECELENLRKATSNANQDNQICSILLQENTFVEQ----VVNEKVKHLE--DTLKEL 344

Query: 356  DKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE 415
            +     L++++   N    N+KL+L          ++ IK      E   +R  +D +F+
Sbjct: 345  ESQHSILKDEVTYMN----NLKLKL-------EMDAQHIKD-----EFFHER--EDLEFK 386

Query: 416  TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL 475
             + +   ++E    +E+L++EL  +  Q         + QH  +++ +K +H+ E+    
Sbjct: 387  INELLLAKEEQGCVIEKLKSELAGLNKQFCY-----TVEQHNREVQSLKEQHQKEISELN 441

Query: 476  RSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE 535
             ++ + +  ++++ LM         ++Q    Q E L++E    +    +L+  +E L  
Sbjct: 442  ETFLSDS-EKEKLTLM--------FEIQGLKEQCENLQQEKQEAILNYESLREIMEILQT 492

Query: 536  ELSFSREQIQRARQTIAEQES----KLNEAHKSLSTVEDLKAEIVSASESRKELELKHEA 591
            EL  S  +I +  +++ +Q++    +L +  ++  T +D   E V+  +   E  L  + 
Sbjct: 493  ELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQE 552

Query: 592  EVTNYKIKLEMLEKEKNAVL-------DRMAESQEAELERLRTQ------LLFSHEEELS 638
             V   +  ++ L+ EKN V        D M +  E ++  L  +       L +  EE+ 
Sbjct: 553  LVPELENTIKNLQ-EKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD 611

Query: 639  KLKEDLEIEHRINIE-KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
               +  E E R+ +E   K    I Y  +++   NE++  +E    EKD    K  +L++
Sbjct: 612  NFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV 671

Query: 698  EISKL-----------------------------KDLQQSLVNSKSEEMTLQINELQKEI 728
            ++  L                             +DL+  L   +   +   I +L+K++
Sbjct: 672  QMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKL 731

Query: 729  EILRQEEKEKGTL--EQEVQELQLKTEL---LEKQMKEKENDLQEK------------FA 771
            +++ +E+     L   ++VQ+L +KT+L   L++   E   D +EK             A
Sbjct: 732  QLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLA 791

Query: 772  QLEAE--NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE-----KEIEI 824
            ++  E  N   + ++K LE  L+      QEE ++  + +KS  +D   E     KE+E 
Sbjct: 792  KINEEKCNLAFQRDEKVLE--LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEE 849

Query: 825  LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884
            +  E E L+   +++    EK R       +N  +  +E+ +  +     K ++ + K K
Sbjct: 850  IQSEKEALQSDLLEMKNANEKTR----LENQNLLIQVEEVSQTCS-----KSEIHNEKEK 900

Query: 885  QELEYKSKLKALNEELHLQRINPTTVKMKS------SVFDEDKTFVAETLEMGEVVEKDT 938
              ++    LK L E+  L+      + +K       SV ++  + V E  E  E +EK+ 
Sbjct: 901  CFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC 960

Query: 939  TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL- 997
             E  EK+   K   ++         ++L     E   + EE++SL+ EK+Q+S   R+L 
Sbjct: 961  KEKEEKINKIKLVAVK-------AKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI 1013

Query: 998  ------------------EIIINHNRAENVQ---------------SCDTQVSSLLDGVV 1024
                              ++ +   RA N +                C+T  S   D + 
Sbjct: 1014 QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA 1073

Query: 1025 TMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084
             + +  +   + +V     + +K MV+ ++  E +      ++EQ I +H  +V +   L
Sbjct: 1074 RIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKL------QKEQKIKEHATTVNELEEL 1127

Query: 1085 RATQPSENDKLQKELN----VLKSEQNDLRLQMEA---QRICLSLVY-----STHVDQVR 1132
            +     E  +LQK +     V K  Q    + ME    +R+   L       +  ++ + 
Sbjct: 1128 QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187

Query: 1133 EYMENEKDKALCSLKEELIFAQ---EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI- 1188
            + ++ +K K   +L+EE+   Q   ++  ++  KI QL ++T K      + +  HL++ 
Sbjct: 1188 QEIKIQKQKQE-TLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQ 1246

Query: 1189 ----GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQD 1244
                G+L+ +  +   Y +Q L  +  E +      + +AE  + +           L  
Sbjct: 1247 ASLKGELEASQQQVEVYKIQ-LAEITSEKHKIHEHLKTSAEQHQRT-----------LSA 1294

Query: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF 1304
            Y+  V   QE       +     ++    + R+  +  QQ +   +   E    K+E E 
Sbjct: 1295 YQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKN-KSMSQAETEGAKQEREH 1353

Query: 1305 LS--IHSQMTNLEDIDVNHKSKLSSLQDLEK---TKLEEQVQELESLISSLQQQLKETEQ 1359
            L   I      L+D   N +  +S LQ L+    T LE   + L+  +S  + +L+E   
Sbjct: 1354 LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSK-EAELREKLC 1412

Query: 1360 NYEAEIHCLQ-KRLQAVSEST 1379
            + ++E   ++ +  Q VS+ T
Sbjct: 1413 SIQSENMMMKSEHTQTVSQLT 1433



 Score =  145 bits (365), Expect = 1e-33
 Identities = 328/1609 (20%), Positives = 682/1609 (42%), Gaps = 222/1609 (13%)

Query: 2179 VEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE--LENKNEEVQQLHMQLE-- 2234
            +E  P+  L    + +   I + +   T LE+++E+ R +   E   + ++ L  +L+  
Sbjct: 22   LETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDAL 81

Query: 2235 -IQKKESTTRLQELEQENKLFKDDME----KLGLAIKESDAMSTQDQHVLFGKFAQIIQE 2289
             ++K E+  +   L++EN   K ++E    K+G A KE      +  H+ + K       
Sbjct: 82   LLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKE-----LEQSHINYVK------- 129

Query: 2290 KEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLE----TQIECLMSDQECVKRNR 2345
               EI+ L  ++  ++        +K  E+K  L + LE    TQ+E  +S+Q   + N 
Sbjct: 130  ---EIENLKNELMAVR--------SKYSEDKANLQKQLEEAMNTQLE--LSEQLKFQNNS 176

Query: 2346 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2405
            E+ +++L E IEK++                  E+   L+ QLD    EK     Q++  
Sbjct: 177  EDNVKKLQEEIEKIRP--------------GFEEQILYLQKQLDATTDEKKETVTQLQNI 222

Query: 2406 NEEMT--FMKNVLKETNFKMNQLTQELFSLKR-ERESVEKIQSIPENSVNVAIDHLSKDK 2462
             E  +  + KN+        N L +EL  LK   +E V+++    E S   A +H     
Sbjct: 223  IEANSQHYQKNI--------NSLQEELLQLKAIHQEEVKELMCQIEAS---AKEH----- 266

Query: 2463 PELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI 2522
             E E+    +  ++L  Q      E + K      E  L  L    S  + +   C    
Sbjct: 267  -EAEINKLNELKENLVKQC-----EASEKNIQKKYECELENLRKATSNANQDNQIC---- 316

Query: 2523 KDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYA-KFCQDNQTISSE- 2580
              + ++  F  +++ +K+ +L+  ++E  +   + + ++  +     K   D Q I  E 
Sbjct: 317  SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF 376

Query: 2581 -PERTNIQ-NLNQL--REDELGSDISALTLRISELESQ---VVEMHT---SLILEKEQVE 2630
              ER +++  +N+L   ++E G  I  L   ++ L  Q    VE H      + E+ Q E
Sbjct: 377  FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE 436

Query: 2631 IAEKNVL-----EKEKKLL--ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSN- 2682
            I+E N       EKEK  L  E+Q L E  E  Q+EK++  +  + E L+   E+  +  
Sbjct: 437  ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQE--AILNYESLREIMEILQTEL 494

Query: 2683 -EESGFFN-ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHL 2740
             E +G  + E E+++ +  +   EL      A   ++ LL     +    + L   ++ +
Sbjct: 495  GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV 554

Query: 2741 AEAKEKLSILEKEDETEVQE-SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILV 2799
             E +  +  L++++   +   S++  M + L  K++     + D   K+ +S++      
Sbjct: 555  PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614

Query: 2800 KNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAA--EILDMESRHISETETLKREH 2857
            K    +  L  E   ++V + I   +E  +K+ EL     E L  + ++  + E L    
Sbjct: 615  KKCEREERLILELG-KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLM--- 670

Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTH 2917
             V +++L E+   L A ++ L                Y+     SS+      + + +  
Sbjct: 671  -VQMKVLSEDKEVLSAEVKSL----------------YEENNKLSSEK-KQLSRDLEVFL 712

Query: 2918 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS 2977
            SQ  D+  +    + E       ++   L + + NE +Q L +    Y   ++    +VS
Sbjct: 713  SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMG-SEVS 771

Query: 2978 EPWLEERKAYINTISSLKDLITKMQ-------LQREAEVYDSSQSHESFSDW---RGELL 3027
            E    E K  +N + ++ + + K+         QR+ +V +  +  +   +    + E L
Sbjct: 772  ED--SEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEEL 829

Query: 3028 LALQQVFLEERSVL---LAAFRTELTALGTTDAVGLLNCLEQ-RIQEQGVEYQAAMECLQ 3083
             +L + + +E+ +L   L   ++E  AL  +D + + N  E+ R++ Q +  Q   E  Q
Sbjct: 830  KSLLRDYEQEKVLLRKELEEIQSEKEAL-QSDLLEMKNANEKTRLENQNLLIQVE-EVSQ 887

Query: 3084 KADRRSLLSEIQA--LHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS-------QML 3134
               +  + +E +   +    N + +  ++E    +    LL+ ++ +  S        + 
Sbjct: 888  TCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVK 947

Query: 3135 EMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3194
            E++ ++ +++    E +E+++  K+V  + K EL  ++ E +T  +       E +    
Sbjct: 948  ELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSA 1007

Query: 3195 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3254
             ++D         + L   +K+S +L   +EKE+A         +  +EDL   L +   
Sbjct: 1008 SMRDLIQGAESYKNLLLEYEKQSEQLD--VEKERAN------NFEHRIEDLTRQLRNS-- 1057

Query: 3255 RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV----RIR 3310
              LQ   +    + LL   +  ++S   L + Q+ E Q     +   LE+EK+    +I+
Sbjct: 1058 -TLQCETINSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115

Query: 3311 EMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLE------EKHSRIVELLN 3364
            E ++T++   EL  QLQ      Q +  +   +L+K+  +Q          + R+++ LN
Sbjct: 1116 EHATTVNELEELQVQLQKEKK--QLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELN 1173

Query: 3365 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL----QRQLE 3420
            +    K + ++  +Q  K ++  ++TLQ E  +     ++  E  +K++ L    +++L 
Sbjct: 1174 QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233

Query: 3421 EKRQQ-----VYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSD 3475
            + +Q      + +  L+G+ L+   Q+ +  +++  E    +  ++++L    T +    
Sbjct: 1234 DSKQAETDHLILQASLKGE-LEASQQQVEVYKIQLAEITSEKHKIHEHLK---TSAEQHQ 1289

Query: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM---IRQKLQCVASKLQVLPQK 3532
            RT +   QQ++    +E   AK  +        ++++ +   ++Q+     S+ +    K
Sbjct: 1290 RTLS-AYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAK 1348

Query: 3533 ASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQN 3592
              ER   E   D+  I +Q++ + + + + +L   Q E  +L+        + +  + + 
Sbjct: 1349 -QEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK---MLQETVSKE 1404

Query: 3593 AELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEK 3652
            AEL   +  +  E     NM+MK E     + QT +   + +    N   +    +   +
Sbjct: 1405 AELREKLCSIQSE-----NMMMKSE-----HTQTVSQLTSQNEVLRN---SFRDQVRHLQ 1451

Query: 3653 EVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRI 3701
            E   +   TLQ+ L + EA++++LK E        T SP S   +LK +
Sbjct: 1452 EEHRKTVETLQQQLSKMEAQLFQLKNE------PTTRSPVSSQQSLKNL 1494



 Score = 37.4 bits (85), Expect = 0.29
 Identities = 79/396 (19%), Positives = 163/396 (41%), Gaps = 63/396 (15%)

Query: 3328 SSDGTGQSR-PPLPSEDLLKELQKQ---LEEKHSRIVELLNETEKYKLDSLQ------TR 3377
            ++ GTG+S+   LP EDL+K  +KQ   +++  SR  EL  E E+ +   +        +
Sbjct: 13   ATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIK 72

Query: 3378 QQMEKDRQVHRKTLQTEQEA------NTEGQKKMHELQSKVEDLQRQLEEKR-QQVYKLD 3430
               E+   +  +  +TEQ+       N + ++++ +  +K+ D  ++LE+     V +++
Sbjct: 73   ALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIE 132

Query: 3431 LEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGET 3490
                 L  +  ++ + +   +++ E        L+E                Q K +  +
Sbjct: 133  NLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSE----------------QLKFQNNS 176

Query: 3491 KESNYAKLIEMNGGGTGCNHELEMIR----QKLQCVASKLQVLPQKASERL-QFETADDE 3545
             E N  KL E          E+E IR    +++  +  +L     +  E + Q +   + 
Sbjct: 177  -EDNVKKLQE----------EIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEA 225

Query: 3546 DFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEE 3605
            +    Q+NI+ +  +L +L     EE            L  ++     E    I++L E 
Sbjct: 226  NSQHYQKNINSLQEELLQLKAIHQEEVK---------ELMCQIEASAKEHEAEINKLNEL 276

Query: 3606 KNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASE----KEVWNREKLT 3661
            K +L       E+ I+   +        +  + N    I +I+  E    ++V N +   
Sbjct: 277  KENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336

Query: 3662 LQKSLKRAEAEVYKLKAELR-NDSLLQTLSPDSEHV 3696
            L+ +LK  E++   LK E+   ++L   L  D++H+
Sbjct: 337  LEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHI 372


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  167 bits (422), Expect = 2e-40
 Identities = 264/1279 (20%), Positives = 560/1279 (43%), Gaps = 194/1279 (15%)

Query: 183  VTYGTEGLQQLQEFEAAIKQRDGI---ITQLTANLQQARREKDETMREFLELTEQSQKLQ 239
            VT+  E +  LQ  E     ++ I   +  +  +L++   E+DE     +EL+E+   L 
Sbjct: 163  VTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH 222

Query: 240  IQFQQLQASET-------LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE 292
                   ++++        R  +    + +L  AK +I   +Q+LEE+   L D +++ E
Sbjct: 223  FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282

Query: 293  DFTMQISFLQEK----------IKVYEMEQDK------KVENSNKEEIQEKETI------ 330
               +++  LQ++           ++Y  E D       +V+    E  + KE +      
Sbjct: 283  QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY 342

Query: 331  ---IEEL--NTKIIEEEKKTLE--LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383
               +EEL  + +++ E K  LE  L+     +DK L EL+++ +Q   ++ +M++E    
Sbjct: 343  KARVEELKEDNQVLLETKTMLEDQLEGTRARSDK-LHELEKENLQLKAKLHDMEME---- 397

Query: 384  KQKERQSSEEIKQLMGTVEELQKRNHKDS---QFETDIVQRMEQETQRKLEQLRAELDEM 440
            +  +R+  EE+ +   T+E  QK++  +S    +E + + R  + ++   + L  E++E+
Sbjct: 398  RDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457

Query: 441  YGQQIVQMKQELIRQHMAQ-MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499
               ++++++ E   Q + + +EE++T       NA +       N+   K + +  NE+ 
Sbjct: 458  TSSRLLKLEME--NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515

Query: 500  IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559
             + Q   + +   K+    +++EK  L++ +E L       RE  +R  + + ++   LN
Sbjct: 516  QEKQSLQNCQNLSKD----LMKEKAQLEKTIETL-------RENSERQIKILEQENEHLN 564

Query: 560  EAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM----- 614
            +   SL     + AE     +  KE ++ HE+ +     KL  +E EK  +   +     
Sbjct: 565  QTVSSLRQRSQISAE-ARVKDIEKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKE 622

Query: 615  ----AESQEAELERL--RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
                AE  E EL  L    +LL      L    E +E   + N E  ++N  +  K+ +D
Sbjct: 623  KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL--KKTLD 680

Query: 669  GLQNEMSQ----KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
              +N   Q    + E  Q +++NL  ++N   L+ + +K  Q  L N   +E+  +  +L
Sbjct: 681  SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN---KELESEKEQL 737

Query: 725  QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
            +K +E+L+   K+   LE   Q L ++ + L+K ++     +Q    QLE+E   L+ E 
Sbjct: 738  KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMEN 793

Query: 785  KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844
            +TL+                     K+  +  +  K +E L +EN+ L+Q+  QL ++  
Sbjct: 794  QTLQ---------------------KNLEELKISSKRLEQLEKENKSLEQETSQLEKD-- 830

Query: 845  KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQR 904
                     +K  E   + L+++     ++KD   +  N +    + + K L++E+ + +
Sbjct: 831  ---------KKQLEKENKRLRQQ----AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877

Query: 905  INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE 964
               + V++K                    +EK+  EL+++  +  +  + L + L  +SE
Sbjct: 878  --ESCVRLKE-------------------LEKENKELVKRATIDIKTLVTLREDL--VSE 914

Query: 965  QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV 1024
            +LK +      +N +++ L  E E++ L  +E  +    +  +  +  ++++ S L   +
Sbjct: 915  KLKTQQ-----MNNDLEKLTHELEKIGLN-KERLLHDEQSTDDRYKLLESKLESTLKKSL 968

Query: 1025 TMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084
             +         +++ +S     ++  E K   +N    ++ + E+ ++   P ++ E + 
Sbjct: 969  EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028

Query: 1085 --RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142
              R +Q +  + L+ +  +++ E+N+  LQ E Q +       T + Q+ E   N     
Sbjct: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQAL------KTQLKQL-ETQNNNLQAQ 1081

Query: 1143 LCSLKEELIFAQEEK--IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKL-----QKAV 1195
            + +L+ + +  QE+   ++      Q+E  T+ +Q T    +   LLI +       ++V
Sbjct: 1082 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1141

Query: 1196 SEECSYFLQTLCSVLGEYYTPALKCEVNAEDKEN----SGDYISENEDPELQDYRYEVQD 1251
             +E         S++ ++    L  E  A + E+     G   S +++ E+     E +D
Sbjct: 1142 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV-----EHRD 1196

Query: 1252 FQENMHTLLNK--VTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHS 1309
             ++  + LL +    E+  K+L ++     +  +  + +  E+  + L  E       +S
Sbjct: 1197 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY--KKLCGENDRLNHTYS 1254

Query: 1310 Q-MTNLEDIDVNHKSKLSSLQD--LEKTKLE-------EQVQELESLISSLQQQ---LKE 1356
            Q +   E +  +HK+  S L +  LE+T+LE       EQ Q+L+   + L  Q   L +
Sbjct: 1255 QLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1314

Query: 1357 TEQNYEAEIHCLQKRLQAV 1375
             + N E E   L  ++Q +
Sbjct: 1315 LKGNLEEENRHLLDQIQTL 1333



 Score =  152 bits (385), Expect = 5e-36
 Identities = 278/1275 (21%), Positives = 558/1275 (43%), Gaps = 224/1275 (17%)

Query: 152  DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGL----QQLQEFEAAIKQRDGII 207
            +S  HL +   ELA  + +I  L +ELEE      TE L    Q+L++ E  +K+     
Sbjct: 244  ESRQHLSV---ELADAKAKIRRLRQELEEK-----TEQLLDCKQELEQMEIELKRLQQEN 295

Query: 208  TQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRN-STHSSTAADLLQA 266
              L ++ + AR  +DE +    E   +  KL+ +  + +  E L +   + +   +L + 
Sbjct: 296  MNLLSDARSARMYRDE-LDALREKAVRVDKLESEVSRYK--ERLHDIEFYKARVEELKED 352

Query: 267  KQQILTHQQQLEEQDHLLEDYQKKKEDF-TMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
             Q +L  +  LE+Q   LE  + + +    ++   LQ K K+++ME ++ ++    EE+ 
Sbjct: 353  NQVLLETKTMLEDQ---LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409

Query: 326  EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN---MKLELTN 382
            E+   +E    + ++E        ++++   +L    Q+ +  +  E+ +   +KLE+ N
Sbjct: 410  EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469

Query: 383  SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442
                 +  ++ +++L  TV+ ++    K        + +ME+E QR  +++     E+  
Sbjct: 470  -----QSLTKTVEELRTTVDSVEGNASK--------ILKMEKENQRLSKKV-----EILE 511

Query: 443  QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR-----SYSNITVNEDQIKLMNVAINE 497
             +IVQ KQ L  Q+   + +   + K ++E  +      S   I + E + + +N  ++ 
Sbjct: 512  NEIVQEKQSL--QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569

Query: 498  LNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK 557
            L  + Q +   + K  E+   IL E     ++    + ++ F + QI++  +   E+  +
Sbjct: 570  LRQRSQISAEARVKDIEKENKILHESI---KETSSKLSKIEFEKRQIKKELEHYKEKGER 626

Query: 558  LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE--KEKNAVLDRMA 615
              E    L  +E             KE EL  + ++TN KI  E +E  +++N+ L+R  
Sbjct: 627  AEELENELHHLE-------------KENELLQK-KITNLKITCEKIEALEQENSELEREN 672

Query: 616  ESQEAELERLR--TQLLFSHEEELSKLKEDLEIEHRINIEKLK------DNLGIHYKQQI 667
               +  L+  +  T  L S E+E S+L E+  +E R N+E LK        L +  K+ +
Sbjct: 673  RKLKKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKE-L 730

Query: 668  DGLQNEMSQKIETMQ--FEK-DNLITKQNQLILEISKL--------KDLQQSLVNSKSEE 716
            +  + ++ + +E ++  F+K + L      L +E  +L        K +QQ  + S+ ++
Sbjct: 731  ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ--LESELQD 788

Query: 717  MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE 776
            + ++   LQK +E L+   K    LE+E + L+ +T  LEK  K+ E + +    Q E +
Sbjct: 789  LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK 848

Query: 777  NSILKDEKKTLEDMLKIHTPVSQE-----ERLIFLDSIKSKSKDSVWEKEIEI--LIEEN 829
            ++ L++    + ++ K +  +S+E     E  + L  ++ ++K+ V    I+I  L+   
Sbjct: 849  DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908

Query: 830  EDL---KQQCIQLNEEIEK----------QRNTFSFAEKNFEVNYQELQEEYACLLK--- 873
            EDL   K +  Q+N ++EK           +      E++ +  Y+ L+ +    LK   
Sbjct: 909  EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL 968

Query: 874  -VKDD--------LEDSKN-KQELEYKSKLKALNEELHLQRIN-PTTVKMKSSVFDEDKT 922
             +K++        LE+S N  Q+L  + K    N E   QR +    V+    +  ED  
Sbjct: 969  EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028

Query: 923  FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKS 982
            +  E+ E      ++  ++ ++L   +R    L      L  QLKQ   + + L  ++ +
Sbjct: 1029 WERESQE----TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084

Query: 983  LKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV--SSLLDGVVTMTSRGAEGSVSKVNK 1040
            L  +++ VSL+          N     Q+   QV  S+L     ++ ++ A+  + +   
Sbjct: 1085 L--QRQTVSLQ--------EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ--S 1132

Query: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100
            S   E++ +++++   +++        + LI DH     K   L   Q SE + L  +  
Sbjct: 1133 SLENENESVIKEREDLKSL-------YDSLIKDH----EKLELLHERQASEYESLISKHG 1181

Query: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 1160
             LKS   +L ++              H D    Y +              +  Q+ ++++
Sbjct: 1182 TLKSAHKNLEVE--------------HRDLEDRYNQ--------------LLKQKGQLED 1213

Query: 1161 LQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSV---LGEYYTPA 1217
            L+K+ ++E + M             LL  K  + V+ E     + LC     L   Y+  
Sbjct: 1214 LEKMLKVEQEKM-------------LLENKNHETVAAE----YKKLCGENDRLNHTYSQL 1256

Query: 1218 LK-CEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR 1276
            LK  EV   D +N    ++ +   +L+  R E +          +K+ E+Y +L +  T+
Sbjct: 1257 LKETEVLQTDHKNLKSLLNNS---KLEQTRLEAE---------FSKLKEQYQQLDITSTK 1304

Query: 1277 LSKIWGQQTDGMKLEFGEEN---LPKEETEFLSIHSQM-TNLEDIDVNH---KSKLSSLQ 1329
            L+    +    +K    EEN   L + +T  L   + +  N+E  D+ H   +  +  L 
Sbjct: 1305 LNN-QCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLN 1363

Query: 1330 DL--EKTKLEEQVQE 1342
            +L  +K KLEE++ +
Sbjct: 1364 ELRRQKEKLEEKIMD 1378



 Score =  150 bits (379), Expect = 2e-35
 Identities = 294/1339 (21%), Positives = 555/1339 (41%), Gaps = 232/1339 (17%)

Query: 1591 RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ---------EEIKRL--NRQLAQ 1639
            ++E + + Q     T+    AH++++   +E+   LQ         E+I+ L  N  L  
Sbjct: 138  KEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL 197

Query: 1640 RSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT 1699
            +  ID  +  SE    L EE + L  L  A          +SS Q+  G+      E + 
Sbjct: 198  KRLIDERDEHSETIIELSEERDGLHFLPHA----------SSSAQSPCGSPGMKRTESRQ 247

Query: 1700 FKEKEL-DRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILD 1758
                EL D K +      +   R  L++   +LL    E+ +    ++  + +  + +L 
Sbjct: 248  HLSVELADAKAK------IRRLRQELEEKTEQLLDCKQELEQMEIELKR-LQQENMNLL- 299

Query: 1759 RSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEG 1818
                S + ++ ++R E +A     + E+  RV D+     S      +DI  +    EE 
Sbjct: 300  ----SDARSARMYRDELDA-----LREKAVRV-DKLESEVSRYKERLHDIEFYKARVEEL 349

Query: 1819 TELSQRLVRSG------FAGT--------EIDPENEELMLNISS-RLQAAVE-KLLEAIS 1862
             E +Q L+ +         GT        E++ EN +L   +    ++  ++ K +E + 
Sbjct: 350  KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409

Query: 1863 ETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE-----------ELRE-------RLH 1904
            E +  LE A   Q + M ES     E  +  +  E           E+ E       +L 
Sbjct: 410  EENMTLEMA---QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466

Query: 1905 EESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964
             E+++  +   EL      ++G A +    E++ Q  +  ++ LE E++     LQ  + 
Sbjct: 467  MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526

Query: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE----KLEVQCQAEKVRDDLQ 2020
              + + +E+  L +  E ++  +    + L QE E L +     +   Q  AE    D++
Sbjct: 527  LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586

Query: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER 2080
            K+ K L   ++E  S+  ++E EK       RQ  + LE   EK      E+A + E+E 
Sbjct: 587  KENKILHESIKETSSKLSKIEFEK-------RQIKKELEHYKEK-----GERAEELENEL 634

Query: 2081 DVFQQE---IQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR 2137
               ++E   +QK    LK+        E +  E+E+    LK+  D    L    E L++
Sbjct: 635  HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK 694

Query: 2138 DIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDA 2197
            +  + +EE   LE R R +E     S    Q   + K   + + + +  LE+ L+A    
Sbjct: 695  ENSQLDEE--NLELR-RNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL-LKASFKK 750

Query: 2198 IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE--------IQK-----KESTTRL 2244
             +R E     L+ + ++ ++ LEN N+++QQL  +L+        +QK     K S+ RL
Sbjct: 751  TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810

Query: 2245 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI----IQEKEVEIDQLNEQ 2300
            ++LE+ENK  + +  +L     E D    + ++    + A+I    ++E  V+I  L ++
Sbjct: 811  EQLEKENKSLEQETSQL-----EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865

Query: 2301 VTKLQQQLKITTDN----KVIEEKN-ELIRDLETQIECLMSDQECVKRNREEEIEQLNEV 2355
               L +++ I  ++    K +E++N EL++     I+ L++ +E +  + + + +Q+N  
Sbjct: 866  NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV-SEKLKTQQMNND 924

Query: 2356 IEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMK 2413
            +EKL  EL  IG       H      D  K     ++  KL   L++ +E   E++  ++
Sbjct: 925  LEKLTHELEKIGLNKERLLHDEQSTDDRYK-----LLESKLESTLKKSLEIKEEKIAALE 979

Query: 2414 NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDA 2473
              L+E+     QL QEL ++K+  E++++ Q                   E  +V +   
Sbjct: 980  ARLEESTNYNQQLRQELKTVKKNYEALKQRQD------------------EERMVQSSPP 1021

Query: 2474 LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFET 2533
            +   +N+   +S E   +  ++ ++ RL+++E   +    E      Q+K ++ Q     
Sbjct: 1022 ISGEDNKWERESQETTRE--LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN--- 1076

Query: 2534 EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLR 2593
              LQ +I+ LQ+                             QT+S + + T +Q  N   
Sbjct: 1077 -NLQAQILALQR-----------------------------QTVSLQEQNTTLQTQN--- 1103

Query: 2594 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGN 2653
                    + L +  S L SQ     TSL+ +  Q+ I + + LE E            N
Sbjct: 1104 --------AKLQVENSTLNSQ----STSLMNQNAQLLIQQSS-LENE------------N 1138

Query: 2654 EKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE 2713
            E   +E+E  +S  D         L   +E+    +E +A   ES+ +K        K  
Sbjct: 1139 ESVIKEREDLKSLYD--------SLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1190

Query: 2714 KLQEELLVKETNMTSLQK-DLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPI 2772
            +++   L    N    QK  L  +   L   +EK+ +  K  ET   E KK C       
Sbjct: 1191 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND--- 1247

Query: 2773 KLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSS-EEVTEIISQFTEKIEK 2830
            +L+ + +     T  + + ++  + L+ N+ + Q  L++E S  +E  + +   + K+  
Sbjct: 1248 RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNN 1307

Query: 2831 MQEL--HAAEILDMESRHI 2847
              EL       L+ E+RH+
Sbjct: 1308 QCELLSQLKGNLEEENRHL 1326



 Score =  149 bits (376), Expect = 5e-35
 Identities = 302/1358 (22%), Positives = 579/1358 (42%), Gaps = 216/1358 (15%)

Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQ----QTELSRISGGKENTASSKQAHAVCQ 1482
            N++ + +  + EQ  EEV K+++ +     Q    +  + RI G   +T ++  AH    
Sbjct: 104  NVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAH---- 159

Query: 1483 QEQHYFNEMKLSQDQI-GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH----- 1536
                   E+  +Q+ +   Q  E  D+  +E+ +PL K +  H K  L+   D H     
Sbjct: 160  -----IQEVTHNQENVFDLQWMEVTDMS-QEDIEPLLKNMALHLKR-LIDERDEHSETII 212

Query: 1537 DIPESKDCVLTISEEMFSKDKTF----IVRQSIHDEISVSSMDA--------------SR 1578
            ++ E +D +  +     S         + R      +SV   DA              + 
Sbjct: 213  ELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTE 272

Query: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638
            QL+  +++LE M  EL R  QE+       R A M      R++ + L+E+  R+++  +
Sbjct: 273  QLLDCKQELEQMEIELKRLQQENMNLLSDARSARM-----YRDELDALREKAVRVDKLES 327

Query: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ 1698
            + S         E  +  +EEL+   Q+ L  +  L  +L  +  ++   +E + E  + 
Sbjct: 328  EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387

Query: 1699 TFK------EKELDRKP-EDVPPEILSNERYALQKANNRL-----LKILLEVVKTTAAVE 1746
              K      E+++DRK  E++  E ++ E    Q  +  L     L+ +    + + A +
Sbjct: 388  KAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ 447

Query: 1747 ETIGRHV-------LGILDRSSKS---------------QSSASLIWRSEAE---ASVKS 1781
            +++G  V       L  L+  ++S               + +AS I + E E    S K 
Sbjct: 448  KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507

Query: 1782 CVHEEHTRVTDESIPSYS--GSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPEN 1839
             + E       +S+ +      D+ +    +  K  E   E S+R ++       ++ EN
Sbjct: 508  EILENEIVQEKQSLQNCQNLSKDLMKEKAQL-EKTIETLRENSERQIKI------LEQEN 560

Query: 1840 EELMLNISSRLQAA----------VEK----LLEAISETSSQLEHAKVTQTELMRESFRQ 1885
            E L   +SS  Q +          +EK    L E+I ETSS+L   +  + ++ +E    
Sbjct: 561  EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620

Query: 1886 KQEATESLKCQEELRERLHEESRAREQLAVELSKAE---GVIDGYADEKTLFERQIQEKT 1942
            K++   +    EEL   LH   +  E L  +++  +     I+    E +  ER+ ++  
Sbjct: 621  KEKGERA----EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676

Query: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
              +D  +      + +L+ LE E  Q+ EE   L R  E++K  A     QL  E ++L 
Sbjct: 677  KTLDSFKN----LTFQLESLEKENSQLDEENLELRRNVESLKC-ASMKMAQLQLENKELE 731

Query: 2003 KEKLEVQCQAEKVRDDLQK----QVKALEIDVEEQ-VSRFIELEQEK----NTELMDLRQ 2053
             EK +++   E ++   +K    +V    +D+E Q + + +E   +K     +EL DL  
Sbjct: 732  SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791

Query: 2054 QNQALEK-------------QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
            +NQ L+K             QLEK  K L+++    E ++   ++E ++L QQ ++  + 
Sbjct: 792  ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI--KD 849

Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR--DIQERNEEIEK-----LEFRV 2153
              + E+  +    + N  KE      E+ + KE   R  ++++ N+E+ K     ++  V
Sbjct: 850  TTLEENNVK----IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905

Query: 2154 RELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2213
               E  +     T Q   D +       K  L+ E  L  E+   DR +   + LE  L 
Sbjct: 906  TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTL- 964

Query: 2214 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2273
              ++ LE K E++  L  +LE    EST   Q+L QE K  K + E   L  ++ +    
Sbjct: 965  --KKSLEIKEEKIAALEARLE----ESTNYNQQLRQELKTVKKNYE--ALKQRQDEERMV 1016

Query: 2274 QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-KITTDNKVIEEKNELIRDLETQIE 2332
            Q    + G+      + E E  +   ++ K++ +L ++  +N  ++ + +    L+TQ++
Sbjct: 1017 QSSPPISGE----DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA---LKTQLK 1069

Query: 2333 CLMSDQECVKRNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQLD 2389
             L    E    N + +I  L      LQ++   L     K  +   +L+ ++ SL +Q  
Sbjct: 1070 QL----ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1125

Query: 2390 VVIAEKLALEQQVETANEEMTFMKNV---LKETNFKMNQLTQELFSLKRERES-VEKIQS 2445
             ++ ++ +LE + E+  +E   +K++   L + + K+  L +   S   E ES + K  +
Sbjct: 1126 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS---EYESLISKHGT 1182

Query: 2446 IPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLE 2505
            +     N+ ++H   +    +++  +  L+ LE               ++ +E   + LE
Sbjct: 1183 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE--------------KMLKVEQEKMLLE 1228

Query: 2506 S----TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL 2561
            +    TV+A+  +L     ++     Q   ETE+LQ    NL+ ++      + + Q +L
Sbjct: 1229 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN----SKLEQTRL 1284

Query: 2562 EAVQEYAKFCQDNQTISSEPERTNIQ--NLNQLR---EDE---LGSDISALTLRISELES 2613
            EA  E++K  +  Q +     + N Q   L+QL+   E+E   L   I  L L+   L  
Sbjct: 1285 EA--EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342

Query: 2614 QVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE 2651
            Q +E      +E+ Q  I + N L ++K+ LE +K+++
Sbjct: 1343 QNMESKDLFHVEQRQY-IDKLNELRRQKEKLE-EKIMD 1378



 Score =  140 bits (353), Expect = 2e-32
 Identities = 303/1470 (20%), Positives = 593/1470 (40%), Gaps = 253/1470 (17%)

Query: 1929 DEKTLFERQIQEKTDI----IDRLEQELLCASNRLQELEAEQQQ----IQEERELLSRQK 1980
            +++ +F+ Q  E TD+    I+ L + +     RL +   E  +    + EER+ L    
Sbjct: 166  NQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLP 225

Query: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
             A  +   P     ++ TE      +E+                    D + ++ R  + 
Sbjct: 226  HASSSAQSPCGSPGMKRTESRQHLSVELA-------------------DAKAKIRRLRQE 266

Query: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
             +EK  +L+D +Q+ + +E +L+++                  QQE   L          
Sbjct: 267  LEEKTEQLLDCKQELEQMEIELKRL------------------QQENMNL---------- 298

Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF---RVRELE 2157
              +S+ ++      A   +++ D   E  +  ++L+ ++    E +  +EF   RV EL+
Sbjct: 299  --LSDARS------ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350

Query: 2158 QALLVSADTFQKVEDRKHFGAVEA-------KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
            +   V  +T   +ED+       +       K  L L+ +L       D   K+I  L E
Sbjct: 351  EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410

Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE-----------NKLFKDDME 2259
              E    E+  K    + LH+  E+++   T+ L E  Q+           ++L K +ME
Sbjct: 411  --ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468

Query: 2260 KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEE 2319
               L     +  +T D   + G  ++I+ + E E  +L+++V  L+ +  I  + + ++ 
Sbjct: 469  NQSLTKTVEELRTTVDS--VEGNASKIL-KMEKENQRLSKKVEILENE--IVQEKQSLQN 523

Query: 2320 KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2379
               L +DL  +   L    E ++ N E +I+ L +  E L Q ++++ Q++ ++A +  +
Sbjct: 524  CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVK 583

Query: 2380 EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERES 2439
            + +     L   I E  +   ++E    ++       KE   +  +L  EL  L++E E 
Sbjct: 584  DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENEL 643

Query: 2440 VEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLET 2499
            ++K            I +L     ++E +  E++    EN+   K+ +     S  NL  
Sbjct: 644  LQK-----------KITNLKITCEKIEALEQENSELERENRKLKKTLD-----SFKNLTF 687

Query: 2500 RLLQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIVEEKVAA 2553
            +L  LE   S  D E  +  + ++ ++       Q Q E + L+ +   L+K + E + A
Sbjct: 688  QLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL-ELLKA 746

Query: 2554 ALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELES 2613
            +     +LE    Y     +NQ +    E +N + + QL  +          L+  E+E+
Sbjct: 747  SFKKTERLEV--SYQGLDIENQRLQKTLENSN-KKIQQLESE----------LQDLEMEN 793

Query: 2614 QVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLK 2673
            Q ++ +    LE+ ++       LEKE K LE +      +KKQ EKE KR  Q  E+  
Sbjct: 794  QTLQKN----LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849

Query: 2674 TTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDL 2733
            TT E   +N + G       L  E+     E+  YKE   +L+E                
Sbjct: 850  TTLE--ENNVKIG------NLEKENKTLSKEIGIYKESCVRLKE---------------- 885

Query: 2734 SQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
                            LEKE++  V   K+A +     + L + + S+   T ++  +N 
Sbjct: 886  ----------------LEKENKELV---KRATIDIKTLVTLREDLVSEKLKTQQM--NND 924

Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETL 2853
              ++  +   I +N +     E+ T+      + +E   E    + L+++   I+  E  
Sbjct: 925  LEKLTHELEKIGLNKERLLHDEQSTD---DRYKLLESKLESTLKKSLEIKEEKIAALEAR 981

Query: 2854 KREHYVAVQLLKEECGTLKAVIQCLRSKEG-----SSIPELAHSDAYQTREICSSDSGSD 2908
              E     Q L++E  T+K   + L+ ++       S P ++  D    RE  S ++  +
Sbjct: 982  LEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE--SQETTRE 1039

Query: 2909 WGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDG 2968
                  L   +   I  E      ++   +   ++K L    +N   Q+L+L     S  
Sbjct: 1040 ------LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS-- 1091

Query: 2969 EDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLL 3028
                        L+E+   + T ++            + +V +S+ + +S S       L
Sbjct: 1092 ------------LQEQNTTLQTQNA------------KLQVENSTLNSQSTSLMNQNAQL 1127

Query: 3029 ALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRR 3088
             +QQ  LE  +  +   R +L +L     +     LE   + Q  EY++ +   +    +
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSL-YDSLIKDHEKLELLHERQASEYESLIS--KHGTLK 1184

Query: 3089 SLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN-----IQQKQSQMLEMQV-ELSS 3142
            S    ++  H  +  R   L +++   +  +++L+       ++ K  + +  +  +L  
Sbjct: 1185 SAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG 1244

Query: 3143 MKDRATELQEQLSSEKMVV----AELKSELAQTKLELETTLKAQHKHLKE-LEAFRLEVK 3197
              DR      QL  E  V+      LKS L  +KLE +T L+A+   LKE  +   +   
Sbjct: 1245 ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE-QTRLEAEFSKLKEQYQQLDITST 1303

Query: 3198 DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL 3257
               ++  LL+    + ++++R L   L++ +  + ++    ++ +E        Q+Q   
Sbjct: 1304 KLNNQCELLSQLKGNLEEENRHL---LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID 1360

Query: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR--NLELQVLLESEK--VRIREMS 3313
            +LN L  Q+++L    ++KI  Q   YD      +G    L+++ L++S+K   R R+ S
Sbjct: 1361 KLNELRRQKEKL----EEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKS 1416

Query: 3314 STLDRERELHAQLQSSDGTGQSRPPLPSED 3343
             TL   R       SS+G  Q    LP +D
Sbjct: 1417 LTLTPTRS-----DSSEGFLQ----LPHQD 1437



 Score =  131 bits (329), Expect = 1e-29
 Identities = 203/993 (20%), Positives = 450/993 (45%), Gaps = 146/993 (14%)

Query: 2    EDEERQKKLEAGKAKLAQFRQ--RKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQ 59
            E++   KK+E  + ++ Q +Q  +  Q+  +   K++ +  KT  +  + S      ++Q
Sbjct: 499  ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558

Query: 60   SQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEI-STTADDCSSEV 118
               +     SS R  S +  E+ +                 +E E++I   +  + SS++
Sbjct: 559  ENEHLNQTVSSLRQRSQISAEARVK---------------DIEKENKILHESIKETSSKL 603

Query: 119  NGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNREL 178
            +   F  R  K     +E E      Y E+G +      E +E+EL   + E E L +++
Sbjct: 604  SKIEFEKRQIK-----KELEH-----YKEKGER-----AEELENELHHLEKENELLQKKI 648

Query: 179  EEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKL 238
              +++T         ++ EA        + Q  + L++  R+  +T+  F  LT Q + L
Sbjct: 649  TNLKIT--------CEKIEA--------LEQENSELERENRKLKKTLDSFKNLTFQLESL 692

Query: 239  QIQFQQLQASET-LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDF--T 295
            + +  QL      LR +  S   A +  A+ Q L +++   E++ L +  +  K  F  T
Sbjct: 693  EKENSQLDEENLELRRNVESLKCASMKMAQLQ-LENKELESEKEQLKKGLELLKASFKKT 751

Query: 296  MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK-DKLTT 354
             ++    + + +      K +ENSNK+ IQ+ E+ +++L     E E +TL+   ++L  
Sbjct: 752  ERLEVSYQGLDIENQRLQKTLENSNKK-IQQLESELQDL-----EMENQTLQKNLEELKI 805

Query: 355  ADKLLGELQEQ---IVQKNQEIKNMKLELTNSKQKERQSSE-------EIKQLMGTVEEL 404
            + K L +L+++   + Q+  +++  K +L    ++ RQ +E       E    +G +E+ 
Sbjct: 806  SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865

Query: 405  QKRNHKD-SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM 463
             K   K+   ++   V+  E E + K    RA +D    + +V ++++L+       E++
Sbjct: 866  NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI---KTLVTLREDLVS------EKL 916

Query: 464  KTRH-KGEMENALRSYSNITVNEDQIKLMNVAINE----LNIKLQDTNSQKEKLKEELGL 518
            KT+    ++E        I +N++++     + ++    L  KL+ T  +  ++KEE   
Sbjct: 917  KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA 976

Query: 519  ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA 578
             LE +          +EE +   +Q+++  +T+ +    L +       V+   +  +S 
Sbjct: 977  ALEAR----------LEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--SPPISG 1024

Query: 579  SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638
             +++ E E   E      K+K  ++E E+N        + +AE + L+TQL    E + +
Sbjct: 1025 EDNKWERE-SQETTRELLKVKDRLIEVERNNA------TLQAEKQALKTQLK-QLETQNN 1076

Query: 639  KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 698
             L+  +    R  +   + N  +  + Q   LQ E S    T+  +  +L+ +  QL+++
Sbjct: 1077 NLQAQILALQRQTVSLQEQNTTL--QTQNAKLQVENS----TLNSQSTSLMNQNAQLLIQ 1130

Query: 699  ISKLKDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEK--------GTLEQEVQEL 748
             S L++  +S++  + +  +L  + ++  +++E+L + +  +        GTL+   + L
Sbjct: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1190

Query: 749  QLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808
            +++     + ++++ N L ++  QLE    +LK E++ +    K H  V+ E + +  ++
Sbjct: 1191 EVE----HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1246

Query: 809  IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868
             +     S   KE E+L  ++++LK   +  N ++E+ R          E  + +L+E+Y
Sbjct: 1247 DRLNHTYSQLLKETEVLQTDHKNLKS--LLNNSKLEQTR---------LEAEFSKLKEQY 1295

Query: 869  ACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL 928
              L     D+  +K   + E  S+LK      +L+  N   +    ++  +++T + + +
Sbjct: 1296 QQL-----DITSTKLNNQCELLSQLKG-----NLEEENRHLLDQIQTLMLQNRTLLEQNM 1345

Query: 929  EMGEVVEKDTTELMEKLEVTKREKLELSQRLSD 961
            E  ++   +  + ++KL   +R+K +L +++ D
Sbjct: 1346 ESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1378



 Score =  116 bits (291), Expect = 4e-25
 Identities = 314/1519 (20%), Positives = 612/1519 (40%), Gaps = 257/1519 (16%)

Query: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQE------ 2043
            V+   L +    +  KLE Q   +KV +D   ++  L I V +    + E  Q+      
Sbjct: 43   VDGVFLNQVMLQINPKLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSL 102

Query: 2044 KNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK--VVPRFQ 2101
             N  ++     ++   ++++K+   L   A+  + +++ F + IQ L+   K  V    Q
Sbjct: 103  PNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQ-KKEEFIERIQGLDFDTKAAVAAHIQ 161

Query: 2102 PISEHQTREVEQLANHLKEKTDKCSELLLSKE--QLQRDIQERNEEIEKLEFRVRELEQA 2159
             ++ +Q    +     + + + +  E LL      L+R I ER+E  E     + EL + 
Sbjct: 162  EVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSET----IIELSEE 217

Query: 2160 LLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEK------EITNLEEQLE 2213
                        D  HF      P  S   Q       + R E       E+ + + ++ 
Sbjct: 218  -----------RDGLHF-----LPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIR 261

Query: 2214 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2273
            + R+ELE K E++     +LE  + E    L+ L+QEN     D     +   E DA+  
Sbjct: 262  RLRQELEEKTEQLLDCKQELEQMEIE----LKRLQQENMNLLSDARSARMYRDELDAL-- 315

Query: 2274 QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIEC 2333
                          +EK V +D+L  +V++ +                E + D+E     
Sbjct: 316  --------------REKAVRVDKLESEVSRYK----------------ERLHDIEFY--- 342

Query: 2334 LMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT---SMNAHSLSEEADSLKHQLDV 2390
                     + R EE+++ N+V+ + +  L +  + T   S   H L +E   LK +L  
Sbjct: 343  ---------KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHD 393

Query: 2391 VIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENS 2450
            +  E+    +++E   EE   ++   K++  +   L  EL  + R  E    +   P+ S
Sbjct: 394  MEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE----LSEAPQKS 449

Query: 2451 VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSA 2510
            +   ++ L+  +     +  +   K++E         E     I+ +E    +L   V  
Sbjct: 450  LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509

Query: 2511 KDLELTQCYKQIKDMQEQGQF---ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY 2567
             + E+ Q  + +++ Q   +    E   L+K I  L++  E ++         LE   E+
Sbjct: 510  LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI-------LEQENEH 562

Query: 2568 AKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE 2627
                  NQT+SS  +R+ I    ++++ E  + I  L   I E  S++ ++      EK 
Sbjct: 563  L-----NQTVSSLRQRSQISAEARVKDIEKENKI--LHESIKETSSKLSKIE----FEKR 611

Query: 2628 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGF 2687
            Q++   ++  EK ++  EL+     NE    EKE +   + +  LK T E   + E+   
Sbjct: 612  QIKKELEHYKEKGERAEELE-----NELHHLEKENELLQKKITNLKITCEKIEALEQ--- 663

Query: 2688 FNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK--- 2744
              E   L  E+   K  L S+K    +L  E L KE +   L ++  ++R ++   K   
Sbjct: 664  --ENSELERENRKLKKTLDSFKNLTFQL--ESLEKENSQ--LDEENLELRRNVESLKCAS 717

Query: 2745 ---EKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
                +L +  KE E+E ++ KK         K ++ +     G   +   NQ  Q  ++N
Sbjct: 718  MKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG---LDIENQRLQKTLEN 774

Query: 2802 AGIQIN-LQSECSSEEVTEIISQFTEKIEKMQELHAA----EILDMESRHIS-ETETLKR 2855
            +  +I  L+SE    E+     Q     + ++EL  +    E L+ E++ +  ET  L++
Sbjct: 775  SNKKIQQLESELQDLEMENQTLQ-----KNLEELKISSKRLEQLEKENKSLEQETSQLEK 829

Query: 2856 EHYVAVQLLKEECGTLK--AVIQCLRSKEGS-SIPELAHSDAYQTREICSSDSGSDWGQG 2912
            +     + L++E   L+  A I+    +E +  I  L   +   ++EI           G
Sbjct: 830  DK----KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI-----------G 874

Query: 2913 IYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHS 2972
            IY               +ES        K+ K L++    +   +++L E   S  E   
Sbjct: 875  IY---------------KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS--EKLK 917

Query: 2973 IQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQ 3032
             QQ++           N +  L   + K+ L +E  ++D   + + +     +L   L++
Sbjct: 918  TQQMN-----------NDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKK 966

Query: 3033 VFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS 3092
              LE +   +AA    L      ++      L Q ++     Y+A     Q+ D   ++ 
Sbjct: 967  S-LEIKEEKIAALEARLE-----ESTNYNQQLRQELKTVKKNYEALK---QRQDEERMVQ 1017

Query: 3093 EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQE 3152
                +  + N      K E+ES++ ++ELL+                   +KDR  E++ 
Sbjct: 1018 SSPPISGEDN------KWERESQETTRELLK-------------------VKDRLIEVER 1052

Query: 3153 QLSSEKMVVAELKSELAQTKLE---LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDT 3209
              ++ +     LK++L Q + +   L+  + A  +    L+     ++ +  ++ + N T
Sbjct: 1053 NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1112

Query: 3210 LASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ- 3268
            L S+          L  +++ L    E   +E EDLK   +S  + + +L LL E+Q   
Sbjct: 1113 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1172

Query: 3269 ---------LLNESQQKIE-SQRMLYDA--QLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
                      L  + + +E   R L D   QL +++G+  +L+ +L   KV   +M    
Sbjct: 1173 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML---KVEQEKMLLEN 1229

Query: 3317 DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3376
                 + A+ +   G         S+ LLKE +  L+  H  +  LLN +   KL+  + 
Sbjct: 1230 KNHETVAAEYKKLCGENDRLNHTYSQ-LLKETE-VLQTDHKNLKSLLNNS---KLEQTRL 1284

Query: 3377 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3436
              +  K ++ +++   T  + N + +  + +L+  +E+  R L +   Q+  L L+ + L
Sbjct: 1285 EAEFSKLKEQYQQLDITSTKLNNQCE-LLSQLKGNLEEENRHLLD---QIQTLMLQNRTL 1340

Query: 3437 QGIMQEFQKQELEREEKRE 3455
              + Q  + ++L   E+R+
Sbjct: 1341 --LEQNMESKDLFHVEQRQ 1357



 Score =  112 bits (279), Expect = 9e-24
 Identities = 238/1133 (21%), Positives = 449/1133 (39%), Gaps = 180/1133 (15%)

Query: 2626 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES 2685
            K ++    + + EK ++LL+ ++ LE     Q E E KR  Q+   L     L  +    
Sbjct: 257  KAKIRRLRQELEEKTEQLLDCKQELE-----QMEIELKRLQQENMNL-----LSDARSAR 306

Query: 2686 GFFNELEALRAESVAT---KAELASYKEK----------AEKLQEELLVKETNMTSLQKD 2732
             + +EL+ALR ++V     ++E++ YKE+           E+L+E+  V     T L+  
Sbjct: 307  MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366

Query: 2733 LSQVR---DHLAEA-KEKLSILEKEDETEVQESKKACMFEPLP---IKLSKSIASQTDGT 2785
            L   R   D L E  KE L +  K  + E++        E L    + L  +     D +
Sbjct: 367  LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426

Query: 2786 L-------KISSSNQTPQILVKNAGIQIN-------LQSECSSEEVTEIISQFTEKIEKM 2831
            L       +IS +++  +   K+ G ++N       L+ E  ++ +T+ + +    ++ +
Sbjct: 427  LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486

Query: 2832 QELHAAEILDMESRH--------------ISETETLKREHYVAVQLLKEECGTLKAVIQC 2877
             E +A++IL ME  +              + E ++L+    ++  L+KE+   L+  I+ 
Sbjct: 487  -EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK-AQLEKTIET 544

Query: 2878 LRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATD 2937
            LR      I  L   + +  + + S                Q   I++E R ++ E    
Sbjct: 545  LRENSERQIKILEQENEHLNQTVSSL--------------RQRSQISAEARVKDIEKENK 590

Query: 2938 SFPKKIK---GLLRAVHNEGMQVLSLTESPYSDGE-DHSIQQVSEPWLEERKAYINTISS 2993
               + IK     L  +  E  Q+    E     GE    ++       +E +     I++
Sbjct: 591  ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650

Query: 2994 LKDLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA 3051
            LK    K++   Q  +E+   ++  +   D    L   L+   LE+ +  L     EL  
Sbjct: 651  LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES--LEKENSQLDEENLELRR 708

Query: 3052 LGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR--RSLLSEIQALHAQMNGRKITLK 3109
                +++   +    ++Q +  E ++  E L+K     ++   + + L     G  I  +
Sbjct: 709  --NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766

Query: 3110 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ------EQLSSEKMVVAE 3163
            R Q++ + S +     IQQ +S++ ++++E  +++    EL+      EQL  E   + +
Sbjct: 767  RLQKTLENSNK----KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822

Query: 3164 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL--------NDTLASE-- 3213
              S+L + K +LE     ++K L++    + E+KD T E + +        N TL+ E  
Sbjct: 823  ETSQLEKDKKQLE----KENKRLRQ----QAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874

Query: 3214 -QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ------- 3265
              K+S      LEKE  +L +    D + L  L+  L S+K +  Q+N  LE+       
Sbjct: 875  IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934

Query: 3266 ---QKQLLNESQQKIESQRMLYDAQLSEEQGRNLE--------LQVLLESE---KVRIRE 3311
                K+ L   +Q  + +  L +++L     ++LE        L+  LE       ++R+
Sbjct: 935  IGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 994

Query: 3312 MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3371
               T+ +  E   Q Q  +   QS PP+  ED      K   E      ELL   ++  +
Sbjct: 995  ELKTVKKNYEALKQRQDEERMVQSSPPISGED-----NKWERESQETTRELLKVKDRL-I 1048

Query: 3372 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431
            +  +    ++ ++Q  +  L+  +  N   Q ++  LQ +   LQ Q    + Q  KL +
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108

Query: 3432 EGQRL---------QGIMQEFQKQELERE-----EKRESRRILYQNLNEPTTWSLTSDRT 3477
            E   L         Q      Q+  LE E     ++RE  + LY         SL  D  
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD--------SLIKDHE 1160

Query: 3478 RNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERL 3537
            +  +L      E + S Y  LI  +G     +  LE+  + L+   ++L     +  +  
Sbjct: 1161 KLELLH-----ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE 1215

Query: 3538 QFETADDEDFIWVQENIDEIILQLQKLTGQQG-----------EEPSLVSPSTSCGSLTE 3586
            +    + E  +   +N + +  + +KL G+             E   L +   +  SL  
Sbjct: 1216 KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN 1275

Query: 3587 RLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3639
                +   L    S+L E+   L     KL  Q     Q     +  +R  L+
Sbjct: 1276 NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1328



 Score = 96.7 bits (239), Expect = 4e-19
 Identities = 270/1363 (19%), Positives = 566/1363 (41%), Gaps = 205/1363 (15%)

Query: 651  NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710
            +IE L  N+ +H K+ ID  ++E S+ I  +  E+D L    +      S          
Sbjct: 185  DIEPLLKNMALHLKRLIDE-RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT 243

Query: 711  NSKSEEMTLQINELQKEIEILRQEEKEKGT----LEQEVQELQLKTELLEKQMKEKENDL 766
             S+ + +++++ + + +I  LRQE +EK       +QE+++++++ + L+++     +D 
Sbjct: 244  ESR-QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302

Query: 767  QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEKEIEIL 825
            +   A++  +      EK    D  K+ + VS+ +ERL  ++  K++         +E L
Sbjct: 303  RS--ARMYRDELDALREKAVRVD--KLESEVSRYKERLHDIEFYKAR---------VEEL 349

Query: 826  IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885
             E+N+ L +    L +++E  R   + ++K  E+  + LQ        +K  L D + ++
Sbjct: 350  KEDNQVLLETKTMLEDQLEGTR---ARSDKLHELEKENLQ--------LKAKLHDMEMER 398

Query: 886  ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945
            +++ K   + + E + L+     ++  +S     +   ++ T E+ E  +K     + +L
Sbjct: 399  DMDRKKIEELMEENMTLEMAQKQSMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457

Query: 946  EVTKREKLEL-SQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH- 1003
              ++  KLE+ +Q L+   E+L+     +       K LK EKE   L  +++EI+ N  
Sbjct: 458  TSSRLLKLEMENQSLTKTVEELRTTVDSVE--GNASKILKMEKENQRLS-KKVEILENEI 514

Query: 1004 -NRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVG 1062
                +++Q+C      L+     +     E ++  + ++   + KI+ ++     N TV 
Sbjct: 515  VQEKQSLQNCQNLSKDLMKEKAQL-----EKTIETLRENSERQIKILEQENEHL-NQTVS 568

Query: 1063 EESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSL 1122
               ++ Q        ++ E+ ++  +  EN  L + +    S+ +  +++ E ++I   L
Sbjct: 569  SLRQRSQ--------ISAEARVKDIE-KENKILHESIKETSSKLS--KIEFEKRQIKKEL 617

Query: 1123 VYSTHVDQVREYMENE-----KDKALCSLKEELIFAQEEKIKEL-QKIHQLELQTMKTQE 1176
             +     +  E +ENE     K+  L   K   +    EKI+ L Q+  +LE +  K ++
Sbjct: 618  EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677

Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE 1236
            T D  K L   +  L+K  S+     L+   +V           ++  E+KE   +    
Sbjct: 678  TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737

Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN 1296
             +  EL    ++  +  E  +  L+   +   K   L+    KI   +++   LE   + 
Sbjct: 738  KKGLELLKASFKKTERLEVSYQGLDIENQRLQK--TLENSNKKIQQLESELQDLEMENQT 795

Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356
            L K             NLE++ ++ K +L  L+  E   LE++  +LE     L+++ K 
Sbjct: 796  LQK-------------NLEELKISSK-RLEQLEK-ENKSLEQETSQLEKDKKQLEKENKR 840

Query: 1357 TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEF 1416
              Q  E            + ++T+                +  +  G+  K+N       
Sbjct: 841  LRQQAE------------IKDTTL---------------EENNVKIGNLEKEN----KTL 869

Query: 1417 SGEFGVKEETNI-VKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSK 1475
            S E G+ +E+ + +K LEK+ +E ++     +   +++              +E+  S K
Sbjct: 870  SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL--------------REDLVSEK 915

Query: 1476 QAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDP 1535
                  QQ  +   ++    ++IG                 L+KE   H ++   S  D 
Sbjct: 916  ---LKTQQMNNDLEKLTHELEKIG-----------------LNKERLLHDEQ---STDDR 952

Query: 1536 HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQ--E 1593
            + + ESK    T+ + +  K++     ++  +E    S + ++QL    ++L+ +++  E
Sbjct: 953  YKLLESK-LESTLKKSLEIKEEKIAALEARLEE----STNYNQQL---RQELKTVKKNYE 1004

Query: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE 1653
             ++Q Q+ ++  +          + +RE QE  +E +K  +R +      +N  L +E++
Sbjct: 1005 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVER--NNATLQAEKQ 1062

Query: 1654 --RVLLEELEALK-----QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELD 1706
              +  L++LE        Q+    R+ +  + +N++ QTQN    + +VE  T   +   
Sbjct: 1063 ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA---KLQVENSTLNSQSTS 1119

Query: 1707 RKPED----VPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSK 1762
               ++    +    L NE  ++ K    L  +   ++K    +E          L    +
Sbjct: 1120 LMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE----------LLHERQ 1169

Query: 1763 SQSSASLIWRSEAEASVKSCVHEEHTRVTD--ESIPSYSGSDMPRNDINMWSKVTEEGTE 1820
            +    SLI +     S    +  EH  + D    +    G      D+    KV +E   
Sbjct: 1170 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ---LEDLEKMLKVEQEKML 1226

Query: 1821 LSQRLVRSGFAG-TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL- 1878
            L  +   +  A   ++  EN+ L  +  S+L    E L        S L ++K+ QT L 
Sbjct: 1227 LENKNHETVAAEYKKLCGENDRLN-HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285

Query: 1879 -----MRESFRQKQEATESLKCQ----EELRERLHEESR-AREQLAVELSKAEGVIDGYA 1928
                 ++E ++Q    +  L  Q     +L+  L EE+R   +Q+   + +   +++   
Sbjct: 1286 AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNM 1345

Query: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971
            + K LF     E+   ID+L  EL     +L+E   +Q +  +
Sbjct: 1346 ESKDLFH---VEQRQYIDKL-NELRRQKEKLEEKIMDQYKFYD 1384



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 169/742 (22%), Positives = 317/742 (42%), Gaps = 101/742 (13%)

Query: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060
            +Q Q++ E  +  Q  +   D +  +   +Q+V   + +V    +  E+T +   D   L
Sbjct: 133  VQCQKKEEFIERIQGLDF--DTKAAVAAHIQEVTHNQENVFDLQWM-EVTDMSQEDIEPL 189

Query: 3061 LNC----LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEK 3116
            L      L++ I E+    +  +E  ++ D    L    +  AQ       +KR +  + 
Sbjct: 190  LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASS-SAQSPCGSPGMKRTESRQH 248

Query: 3117 PSQEL---------LEYNIQQKQSQMLEMQVELSSMKDRATELQEQ-------------- 3153
             S EL         L   +++K  Q+L+ + EL  M+     LQ++              
Sbjct: 249  LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308

Query: 3154 ------LSSEKMVVAELKSELAQTKLELETT--LKAQHKHLKELEAFRLEVKDKTDEVHL 3205
                  L  + + V +L+SE+++ K  L      KA+ + LKE     LE K       +
Sbjct: 309  RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT------M 362

Query: 3206 LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL---NLL 3262
            L D L   + +S +L   LEKE  +L       K +L D++   +  +++  +L   N+ 
Sbjct: 363  LEDQLEGTRARSDKLH-ELEKENLQL-------KAKLHDMEMERDMDRKKIEELMEENMT 414

Query: 3263 LEQ-QKQLLNES-QQKIESQRMLYDAQLSEEQGRNL--ELQVLLESEKVRIREMSSTLDR 3318
            LE  QKQ ++ES     E +++   ++LSE   ++L  E+  L  S  +++   + +L +
Sbjct: 415  LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTK 474

Query: 3319 E-RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT- 3376
               EL   + S +G       +  E+  + L K++E   + IV+     EK  L + Q  
Sbjct: 475  TVEELRTTVDSVEGNASKILKMEKEN--QRLSKKVEILENEIVQ-----EKQSLQNCQNL 527

Query: 3377 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3436
             + + K++    KT++T +E N+E Q K+  L+ + E L + +   RQ+           
Sbjct: 528  SKDLMKEKAQLEKTIETLRE-NSERQIKI--LEQENEHLNQTVSSLRQR----------- 573

Query: 3437 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3496
              I  E + +++E+E K     IL++++ E T+  L+        +++++E   ++   A
Sbjct: 574  SQISAEARVKDIEKENK-----ILHESIKE-TSSKLSKIEFEKRQIKKELEHYKEKGERA 627

Query: 3497 KLIEMNGGGTGCNHELEMIRQK---LQCVASKLQVLPQKASERLQFETADDEDFIWVQEN 3553
            +  E+         E E++++K   L+    K++ L Q+ SE L+ E    +  +   +N
Sbjct: 628  E--ELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE-LERENRKLKKTLDSFKN 684

Query: 3554 IDEIILQLQKLTGQQGEEPSLVS---PSTSCGSL-TERLLRQNAELTGHISQLTEEKNDL 3609
            +   +  L+K   Q  EE   +     S  C S+   +L  +N EL     QL +    L
Sbjct: 685  LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744

Query: 3610 RNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRA 3669
            +    K E     Y+          +   N    I+  + SE +    E  TLQK+L+  
Sbjct: 745  KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ-LESELQDLEMENQTLQKNLEEL 803

Query: 3670 EAEVYKL-KAELRNDSLLQTLS 3690
            +    +L + E  N SL Q  S
Sbjct: 804  KISSKRLEQLEKENKSLEQETS 825


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  166 bits (420), Expect = 4e-40
 Identities = 294/1277 (23%), Positives = 546/1277 (42%), Gaps = 185/1277 (14%)

Query: 183  VTYGTEGLQQLQEFEAAIKQRDGI---ITQLTANLQQARREKDETMREFLELTEQSQKLQ 239
            VT+  E +  LQ  E     ++ I   +  +  +L++   E+DE     +EL+E+   L 
Sbjct: 163  VTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH 222

Query: 240  IQFQQLQASET-------LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE 292
                   ++++        R  +    + +L  AK +I   +Q+LEE+   L D +++ E
Sbjct: 223  FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282

Query: 293  DFTMQISFLQEK----------IKVYEMEQDK------KVENSNKEEIQEKETI------ 330
               +++  LQ++           ++Y  E D       +V+    E  + KE +      
Sbjct: 283  QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY 342

Query: 331  ---IEEL--NTKIIEEEKKTLE--LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383
               +EEL  + +++ E K  LE  L+     +DK L EL+++ +Q   ++ +M++E    
Sbjct: 343  KARVEELKEDNQVLLETKTMLEDQLEGTRARSDK-LHELEKENLQLKAKLHDMEME---- 397

Query: 384  KQKERQSSEEIKQLMGTVEELQKRNHKDS---QFETDIVQRMEQETQRKLEQLRAELDEM 440
            +  +R+  EE+ +   T+E  QK++  +S    +E + + R  + ++   + L  E++E+
Sbjct: 398  RDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457

Query: 441  YGQQIVQMKQELIRQHMAQ-MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499
               ++++++ E   Q + + +EE++T       NA +       N+   K + +  NE+ 
Sbjct: 458  TSSRLLKLEME--NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515

Query: 500  IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559
             + Q   + +   K+    +++EK  L++ +E L       RE  +R  + + ++   LN
Sbjct: 516  QEKQSLQNCQNLSKD----LMKEKAQLEKTIETL-------RENSERQIKILEQENEHLN 564

Query: 560  EAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM----- 614
            +   SL     + AE     +  KE ++ HE+ +     KL  +E EK  +   +     
Sbjct: 565  QTVSSLRQRSQISAE-ARVKDIEKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKE 622

Query: 615  ----AESQEAELERL--RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
                AE  E EL  L    +LL      L    E +E   + N E  ++N  +  K+ +D
Sbjct: 623  KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL--KKTLD 680

Query: 669  GLQNEMSQ----KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
              +N   Q    + E  Q +++NL  ++N   L+ + +K  Q  L N   +E+  +  +L
Sbjct: 681  SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN---KELESEKEQL 737

Query: 725  QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
            +K +E+L+   K+   LE   Q L ++ + L+K ++     +Q    QLE+E   L+ E 
Sbjct: 738  KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMEN 793

Query: 785  KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844
            +TL+  L         E L     I SK  + + EKE + L +E   L++   QL +E +
Sbjct: 794  QTLQKNL---------EEL----KISSKRLEQL-EKENKSLEQETSQLEKDKKQLEKENK 839

Query: 845  KQRNTFSFAEKNFE---VNYQELQEEYACLLK-VKDDLEDSKNKQELEYKSKLKALNEEL 900
            + R      +   E   V    L++E   L K +    E     +ELE ++K       +
Sbjct: 840  RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899

Query: 901  HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
             ++    T V ++  +  E      +T +M   +EK T EL EK+ + K   L   Q   
Sbjct: 900  DIK----TLVTLREDLVSEK----LKTQQMNNDLEKLTHEL-EKIGLNKERLLHDEQSTD 950

Query: 961  DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020
            D   +L +   E +      KSL+ ++E+++     LE   N+N     Q    ++ ++ 
Sbjct: 951  DSRYKLLESKLESTL----KKSLEIKEEKIAALEARLEESTNYN-----QQLRQELKTVK 1001

Query: 1021 DGVVTMTSR-GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVT 1079
                 +  R   E  V       GE++K   E +         E +++   + D L  V 
Sbjct: 1002 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQ---------ETTRELLKVKDRLIEVE 1052

Query: 1080 KESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEA-QRICLSL-VYSTHVD------QV 1131
            + +   AT  +E   L+ +L  L+++ N+L+ Q+ A QR  +SL   +T +       QV
Sbjct: 1053 RNN---ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109

Query: 1132 REYMENEKDKALCSLKEELIFAQ-------EEKIKELQKIHQLELQTMKTQETGDEGKPL 1184
                 N +  +L +   +L+  Q       E  IKE + +  L    +K  E        
Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-------- 1161

Query: 1185 HLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQD 1244
                 KL+     + S + ++L S  G   +     EV   D E+  + + + +  +L+D
Sbjct: 1162 -----KLELLHERQASEY-ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG-QLED 1214

Query: 1245 YRYEVQDFQENMHTLLNK----VTEEYNKLLVLQTRLSKIWGQ--------QTDGMKLEF 1292
                ++  QE M  L NK    V  EY KL     RL+  + Q        QTD   L+ 
Sbjct: 1215 LEKMLKVEQEKM-LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273

Query: 1293 GEENLPKEET----EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLIS 1348
               N   E+T    EF  +  Q   L+       ++   L  L K  LEE+ + L   I 
Sbjct: 1274 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL-KGNLEEENRHLLDQIQ 1332

Query: 1349 SLQQQLKE-TEQNYEAE 1364
            +L  Q +   EQN E++
Sbjct: 1333 TLMLQNRTLLEQNMESK 1349



 Score =  154 bits (390), Expect = 1e-36
 Identities = 274/1258 (21%), Positives = 551/1258 (43%), Gaps = 189/1258 (15%)

Query: 152  DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGL----QQLQEFEAAIKQRDGII 207
            +S  HL +   ELA  + +I  L +ELEE      TE L    Q+L++ E  +K+     
Sbjct: 244  ESRQHLSV---ELADAKAKIRRLRQELEEK-----TEQLLDCKQELEQMEIELKRLQQEN 295

Query: 208  TQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRN-STHSSTAADLLQA 266
              L ++ + AR  +DE +    E   +  KL+ +  + +  E L +   + +   +L + 
Sbjct: 296  MNLLSDARSARMYRDE-LDALREKAVRVDKLESEVSRYK--ERLHDIEFYKARVEELKED 352

Query: 267  KQQILTHQQQLEEQDHLLEDYQKKKEDF-TMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
             Q +L  +  LE+Q   LE  + + +    ++   LQ K K+++ME ++ ++    EE+ 
Sbjct: 353  NQVLLETKTMLEDQ---LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409

Query: 326  EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN---MKLELTN 382
            E+   +E    + ++E        ++++   +L    Q+ +  +  E+ +   +KLE+ N
Sbjct: 410  EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469

Query: 383  SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442
                 +  ++ +++L  TV+ ++    K        + +ME+E QR  +++     E+  
Sbjct: 470  -----QSLTKTVEELRTTVDSVEGNASK--------ILKMEKENQRLSKKV-----EILE 511

Query: 443  QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR-----SYSNITVNEDQIKLMNVAINE 497
             +IVQ KQ L  Q+   + +   + K ++E  +      S   I + E + + +N  ++ 
Sbjct: 512  NEIVQEKQSL--QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569

Query: 498  LNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK 557
            L  + Q +   + K  E+   IL E     ++    + ++ F + QI++  +   E+  +
Sbjct: 570  LRQRSQISAEARVKDIEKENKILHESI---KETSSKLSKIEFEKRQIKKELEHYKEKGER 626

Query: 558  LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE--KEKNAVLDRMA 615
              E    L  +E             KE EL  + ++TN KI  E +E  +++N+ L+R  
Sbjct: 627  AEELENELHHLE-------------KENELLQK-KITNLKITCEKIEALEQENSELEREN 672

Query: 616  ESQEAELERLR--TQLLFSHEEELSKLKEDLEIEHRINIEKLK------DNLGIHYKQQI 667
               +  L+  +  T  L S E+E S+L E+  +E R N+E LK        L +  K+ +
Sbjct: 673  RKLKKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKE-L 730

Query: 668  DGLQNEMSQKIETMQ--FEK-DNLITKQNQLILEISKL--------KDLQQSLVNSKSEE 716
            +  + ++ + +E ++  F+K + L      L +E  +L        K +QQ  + S+ ++
Sbjct: 731  ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ--LESELQD 788

Query: 717  MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE 776
            + ++   LQK +E L+   K    LE+E + L+ +T  LEK  K+ E + +    Q E +
Sbjct: 789  LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK 848

Query: 777  NSILKDEKKTLEDMLKIHTPVSQE-----ERLIFLDSIKSKSKDSVWEKEIEI--LIEEN 829
            ++ L++    + ++ K +  +S+E     E  + L  ++ ++K+ V    I+I  L+   
Sbjct: 849  DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908

Query: 830  EDL---KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQE 886
            EDL   K +  Q+N ++EK  +       N E    + Q       K+ +   +S  K+ 
Sbjct: 909  EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968

Query: 887  LEYK-SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA-ETLEMGEVVEKDTTELMEK 944
            LE K  K+ AL  E  L+       +++  +    K + A +  +  E + + +  +  +
Sbjct: 969  LEIKEEKIAAL--EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1026

Query: 945  LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004
                +RE  E ++ L  + ++L +     + L  E ++LK + +Q+  +        N+N
Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ--------NNN 1078

Query: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064
                + +   Q  SL +   T+ ++ A                     K+  EN T+  +
Sbjct: 1079 LQAQILALQRQTVSLQEQNTTLQTQNA---------------------KLQVENSTLNSQ 1117

Query: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS-------EQNDLRLQMEAQR 1117
            S    L+  +   + ++SSL     +EN+ + KE   LKS       +   L L  E Q 
Sbjct: 1118 S--TSLMNQNAQLLIQQSSLE----NENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1171

Query: 1118 ICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQET 1177
                 + S H      +   E +      +   +  Q+ ++++L+K+ ++E + M     
Sbjct: 1172 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM----- 1226

Query: 1178 GDEGKPLHLLIGKLQKAVSEECSYFLQTLCSV---LGEYYTPALK-CEVNAEDKENSGDY 1233
                    LL  K  + V+ E     + LC     L   Y+  LK  EV   D +N    
Sbjct: 1227 --------LLENKNHETVAAE----YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL 1274

Query: 1234 ISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG 1293
            ++ +   +L+  R E +          +K+ E+Y +L +  T+L+    +    +K    
Sbjct: 1275 LNNS---KLEQTRLEAE---------FSKLKEQYQQLDITSTKLNN-QCELLSQLKGNLE 1321

Query: 1294 EEN---LPKEETEFLSIHSQM-TNLEDIDVNH---KSKLSSLQDL--EKTKLEEQVQE 1342
            EEN   L + +T  L   + +  N+E  D+ H   +  +  L +L  +K KLEE++ +
Sbjct: 1322 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379



 Score =  149 bits (375), Expect = 7e-35
 Identities = 303/1359 (22%), Positives = 580/1359 (42%), Gaps = 217/1359 (15%)

Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQ----QTELSRISGGKENTASSKQAHAVCQ 1482
            N++ + +  + EQ  EEV K+++ +     Q    +  + RI G   +T ++  AH    
Sbjct: 104  NVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAH---- 159

Query: 1483 QEQHYFNEMKLSQDQI-GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH----- 1536
                   E+  +Q+ +   Q  E  D+  +E+ +PL K +  H K  L+   D H     
Sbjct: 160  -----IQEVTHNQENVFDLQWMEVTDMS-QEDIEPLLKNMALHLKR-LIDERDEHSETII 212

Query: 1537 DIPESKDCVLTISEEMFSKDKTF----IVRQSIHDEISVSSMDA--------------SR 1578
            ++ E +D +  +     S         + R      +SV   DA              + 
Sbjct: 213  ELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTE 272

Query: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638
            QL+  +++LE M  EL R  QE+       R A M      R++ + L+E+  R+++  +
Sbjct: 273  QLLDCKQELEQMEIELKRLQQENMNLLSDARSARM-----YRDELDALREKAVRVDKLES 327

Query: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ 1698
            + S         E  +  +EEL+   Q+ L  +  L  +L  +  ++   +E + E  + 
Sbjct: 328  EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387

Query: 1699 TFK------EKELDRKP-EDVPPEILSNERYALQKANNRL-----LKILLEVVKTTAAVE 1746
              K      E+++DRK  E++  E ++ E    Q  +  L     L+ +    + + A +
Sbjct: 388  KAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ 447

Query: 1747 ETIGRHV-------LGILDRSSKS---------------QSSASLIWRSEAE---ASVKS 1781
            +++G  V       L  L+  ++S               + +AS I + E E    S K 
Sbjct: 448  KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507

Query: 1782 CVHEEHTRVTDESIPSYS--GSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPEN 1839
             + E       +S+ +      D+ +    +  K  E   E S+R ++       ++ EN
Sbjct: 508  EILENEIVQEKQSLQNCQNLSKDLMKEKAQL-EKTIETLRENSERQIKI------LEQEN 560

Query: 1840 EELMLNISSRLQAA----------VEK----LLEAISETSSQLEHAKVTQTELMRESFRQ 1885
            E L   +SS  Q +          +EK    L E+I ETSS+L   +  + ++ +E    
Sbjct: 561  EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620

Query: 1886 KQEATESLKCQEELRERLHEESRAREQLAVELSKAE---GVIDGYADEKTLFERQIQEKT 1942
            K++   +    EEL   LH   +  E L  +++  +     I+    E +  ER+ ++  
Sbjct: 621  KEKGERA----EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676

Query: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
              +D  +      + +L+ LE E  Q+ EE   L R  E++K  A     QL  E ++L 
Sbjct: 677  KTLDSFKN----LTFQLESLEKENSQLDEENLELRRNVESLKC-ASMKMAQLQLENKELE 731

Query: 2003 KEKLEVQCQAEKVRDDLQK----QVKALEIDVEEQ-VSRFIELEQEK----NTELMDLRQ 2053
             EK +++   E ++   +K    +V    +D+E Q + + +E   +K     +EL DL  
Sbjct: 732  SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791

Query: 2054 QNQALEK-------------QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
            +NQ L+K             QLEK  K L+++    E ++   ++E ++L QQ ++  + 
Sbjct: 792  ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI--KD 849

Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR--DIQERNEEIEK-----LEFRV 2153
              + E+  +    + N  KE      E+ + KE   R  ++++ N+E+ K     ++  V
Sbjct: 850  TTLEENNVK----IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905

Query: 2154 RELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2213
               E  +     T Q   D +       K  L+ E  L  E+   D + K    LE +LE
Sbjct: 906  TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYK---LLESKLE 962

Query: 2214 Q-FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMS 2272
               ++ LE K E++  L  +LE    EST   Q+L QE K  K + E   L  ++ +   
Sbjct: 963  STLKKSLEIKEEKIAALEARLE----ESTNYNQQLRQELKTVKKNYE--ALKQRQDEERM 1016

Query: 2273 TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-KITTDNKVIEEKNELIRDLETQI 2331
             Q    + G+      + E E  +   ++ K++ +L ++  +N  ++ + +    L+TQ+
Sbjct: 1017 VQSSPPISGE----DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA---LKTQL 1069

Query: 2332 ECLMSDQECVKRNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQL 2388
            + L    E    N + +I  L      LQ++   L     K  +   +L+ ++ SL +Q 
Sbjct: 1070 KQL----ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQN 1125

Query: 2389 DVVIAEKLALEQQVETANEEMTFMKNV---LKETNFKMNQLTQELFSLKRERES-VEKIQ 2444
              ++ ++ +LE + E+  +E   +K++   L + + K+  L +   S   E ES + K  
Sbjct: 1126 AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS---EYESLISKHG 1182

Query: 2445 SIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQL 2504
            ++     N+ ++H   +    +++  +  L+ LE               ++ +E   + L
Sbjct: 1183 TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE--------------KMLKVEQEKMLL 1228

Query: 2505 ES----TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQ 2560
            E+    TV+A+  +L     ++     Q   ETE+LQ    NL+ ++      + + Q +
Sbjct: 1229 ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN----SKLEQTR 1284

Query: 2561 LEAVQEYAKFCQDNQTISSEPERTNIQ--NLNQLR---EDE---LGSDISALTLRISELE 2612
            LEA  E++K  +  Q +     + N Q   L+QL+   E+E   L   I  L L+   L 
Sbjct: 1285 LEA--EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLL 1342

Query: 2613 SQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE 2651
             Q +E      +E+ Q  I + N L ++K+ LE +K+++
Sbjct: 1343 EQNMESKDLFHVEQRQY-IDKLNELRRQKEKLE-EKIMD 1379



 Score =  147 bits (371), Expect = 2e-34
 Identities = 287/1354 (21%), Positives = 562/1354 (41%), Gaps = 208/1354 (15%)

Query: 2039 ELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
            E  Q  + EL D + + + L ++LE+      EQ +D + E +  + E+++L+Q+     
Sbjct: 244  ESRQHLSVELADAKAKIRRLRQELEEKT----EQLLDCKQELEQMEIELKRLQQE----- 294

Query: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF---RVRE 2155
                +S+ ++      A   +++ D   E  +  ++L+ ++    E +  +EF   RV E
Sbjct: 295  NMNLLSDARS------ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE 348

Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEA-------KPELSLEVQLQAERDAIDRKEKEITNL 2208
            L++   V  +T   +ED+       +       K  L L+ +L       D   K+I  L
Sbjct: 349  LKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL 408

Query: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQEN-----------KLFKDD 2257
             E  E    E+  K    + LH+  E+++   T+ L E  Q++           +L K +
Sbjct: 409  ME--ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466

Query: 2258 MEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVI 2317
            ME   L     +  +T D   + G  ++I++  E E  +L+++V  L+ +  I  + + +
Sbjct: 467  MENQSLTKTVEELRTTVDS--VEGNASKILK-MEKENQRLSKKVEILENE--IVQEKQSL 521

Query: 2318 EEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSL 2377
            +    L +DL  +   L    E ++ N E +I+ L +  E L Q ++++ Q++ ++A + 
Sbjct: 522  QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEAR 581

Query: 2378 SEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER 2437
             ++ +     L   I E  +   ++E    ++       KE   +  +L  EL  L++E 
Sbjct: 582  VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN 641

Query: 2438 ESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINL 2497
            E ++K            I +L     ++E +  E++    EN+   K+ +     S  NL
Sbjct: 642  ELLQK-----------KITNLKITCEKIEALEQENSELERENRKLKKTLD-----SFKNL 685

Query: 2498 ETRLLQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIVEEKV 2551
              +L  LE   S  D E  +  + ++ ++       Q Q E + L+ +   L+K +E  +
Sbjct: 686  TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE-LL 744

Query: 2552 AAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISEL 2611
             A+     +LE    Y     +NQ +    E +N + + QL  +          L+  E+
Sbjct: 745  KASFKKTERLEV--SYQGLDIENQRLQKTLENSN-KKIQQLESE----------LQDLEM 791

Query: 2612 ESQVVEMHTSLILEKEQVEIAEKNV--LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDV 2669
            E+Q ++ +       E+++I+ K +  LEKE K LE +      +KKQ EKE KR  Q  
Sbjct: 792  ENQTLQKNL------EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845

Query: 2670 EVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSL 2729
            E+  TT E   +N + G       L  E+     E+  YKE   +L+E            
Sbjct: 846  EIKDTTLE--ENNVKIG------NLEKENKTLSKEIGIYKESCVRLKE------------ 885

Query: 2730 QKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2789
                                LEKE++  V   K+A +     + L + + S+   T ++ 
Sbjct: 886  --------------------LEKENKELV---KRATIDIKTLVTLREDLVSEKLKTQQM- 921

Query: 2790 SSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISE 2849
             +N   ++  +   I +N +     E+ T+      + +E   E    + L+++   I+ 
Sbjct: 922  -NNDLEKLTHELEKIGLNKERLLHDEQSTD--DSRYKLLESKLESTLKKSLEIKEEKIAA 978

Query: 2850 TETLKREHYVAVQLLKEECGTLKAVIQCLRSKEG-----SSIPELAHSDAYQTREICSSD 2904
             E    E     Q L++E  T+K   + L+ ++       S P ++  D    RE  S +
Sbjct: 979  LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE--SQE 1036

Query: 2905 SGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESP 2964
            +  +      L   +   I  E      ++   +   ++K L    +N   Q+L+L    
Sbjct: 1037 TTRE------LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090

Query: 2965 YSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRG 3024
             S              L+E+   + T ++            + +V +S+ + +S S    
Sbjct: 1091 VS--------------LQEQNTTLQTQNA------------KLQVENSTLNSQSTSLMNQ 1124

Query: 3025 ELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK 3084
               L +QQ  LE  +  +   R +L +L     +     LE   + Q  EY++ +   + 
Sbjct: 1125 NAQLLIQQSSLENENESVIKEREDLKSL-YDSLIKDHEKLELLHERQASEYESLIS--KH 1181

Query: 3085 ADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN-----IQQKQSQMLEMQV- 3138
               +S    ++  H  +  R   L +++   +  +++L+       ++ K  + +  +  
Sbjct: 1182 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYK 1241

Query: 3139 ELSSMKDRATELQEQLSSEKMVV----AELKSELAQTKLELETTLKAQHKHLKE-LEAFR 3193
            +L    DR      QL  E  V+      LKS L  +KLE +T L+A+   LKE  +   
Sbjct: 1242 KLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE-QTRLEAEFSKLKEQYQQLD 1300

Query: 3194 LEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQK 3253
            +      ++  LL+    + ++++R L   L++ +  + ++    ++ +E        Q+
Sbjct: 1301 ITSTKLNNQCELLSQLKGNLEEENRHL---LDQIQTLMLQNRTLLEQNMESKDLFHVEQR 1357

Query: 3254 QRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR--NLELQVLLESEK--VRI 3309
            Q   +LN L  Q+++L    ++KI  Q   YD      +G    L+++ L++S+K   R 
Sbjct: 1358 QYIDKLNELRRQKEKL----EEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRE 1413

Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3343
            R+ S TL   R       SS+G  Q    LP +D
Sbjct: 1414 RQKSLTLTPTRS-----DSSEGFLQ----LPHQD 1438



 Score =  134 bits (336), Expect = 2e-30
 Identities = 206/989 (20%), Positives = 452/989 (45%), Gaps = 137/989 (13%)

Query: 2    EDEERQKKLEAGKAKLAQFRQ--RKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQ 59
            E++   KK+E  + ++ Q +Q  +  Q+  +   K++ +  KT  +  + S      ++Q
Sbjct: 499  ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558

Query: 60   SQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEI-STTADDCSSEV 118
               +     SS R  S +  E+ +                 +E E++I   +  + SS++
Sbjct: 559  ENEHLNQTVSSLRQRSQISAEARVK---------------DIEKENKILHESIKETSSKL 603

Query: 119  NGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNREL 178
            +   F  R  K     +E E      Y E+G +      E +E+EL   + E E L +++
Sbjct: 604  SKIEFEKRQIK-----KELEH-----YKEKGER-----AEELENELHHLEKENELLQKKI 648

Query: 179  EEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKL 238
              +++T         ++ EA        + Q  + L++  R+  +T+  F  LT Q + L
Sbjct: 649  TNLKIT--------CEKIEA--------LEQENSELERENRKLKKTLDSFKNLTFQLESL 692

Query: 239  QIQFQQLQASET-LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDF--T 295
            + +  QL      LR +  S   A +  A+ Q L +++   E++ L +  +  K  F  T
Sbjct: 693  EKENSQLDEENLELRRNVESLKCASMKMAQLQ-LENKELESEKEQLKKGLELLKASFKKT 751

Query: 296  MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK-DKLTT 354
             ++    + + +      K +ENSNK+ IQ+ E+ +++L     E E +TL+   ++L  
Sbjct: 752  ERLEVSYQGLDIENQRLQKTLENSNKK-IQQLESELQDL-----EMENQTLQKNLEELKI 805

Query: 355  ADKLLGELQEQ---IVQKNQEIKNMKLELTNSKQKERQSSE-------EIKQLMGTVEEL 404
            + K L +L+++   + Q+  +++  K +L    ++ RQ +E       E    +G +E+ 
Sbjct: 806  SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865

Query: 405  QKRNHKD-SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM 463
             K   K+   ++   V+  E E + K    RA +D    + +V ++++L+       E++
Sbjct: 866  NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI---KTLVTLREDLVS------EKL 916

Query: 464  KTRH-KGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522
            KT+    ++E        I +N++++     + ++   KL ++  +   LK+ L  I EE
Sbjct: 917  KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST-LKKSLE-IKEE 974

Query: 523  KCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESR 582
            K A    LE  +EE +   +Q+++  +T+ +    L +       V+   +  +S  +++
Sbjct: 975  KIAA---LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--SPPISGEDNK 1029

Query: 583  KELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKE 642
             E E   E      K+K  ++E E+N        + +AE + L+TQL    E + + L+ 
Sbjct: 1030 WERE-SQETTRELLKVKDRLIEVERNNA------TLQAEKQALKTQLK-QLETQNNNLQA 1081

Query: 643  DLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL 702
             +    R  +   + N  +  + Q   LQ E S    T+  +  +L+ +  QL+++ S L
Sbjct: 1082 QILALQRQTVSLQEQNTTL--QTQNAKLQVENS----TLNSQSTSLMNQNAQLLIQQSSL 1135

Query: 703  KDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEK--------GTLEQEVQELQLKT 752
            ++  +S++  + +  +L  + ++  +++E+L + +  +        GTL+   + L+++ 
Sbjct: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE- 1194

Query: 753  ELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
                + ++++ N L ++  QLE    +LK E++ +    K H  V+ E + +  ++ +  
Sbjct: 1195 ---HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1251

Query: 813  SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872
               S   KE E+L  ++++LK   +  N ++E+ R          E  + +L+E+Y  L 
Sbjct: 1252 HTYSQLLKETEVLQTDHKNLKS--LLNNSKLEQTR---------LEAEFSKLKEQYQQL- 1299

Query: 873  KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGE 932
                D+  +K   + E  S+LK      +L+  N   +    ++  +++T + + +E  +
Sbjct: 1300 ----DITSTKLNNQCELLSQLKG-----NLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350

Query: 933  VVEKDTTELMEKLEVTKREKLELSQRLSD 961
            +   +  + ++KL   +R+K +L +++ D
Sbjct: 1351 LFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379



 Score =  110 bits (275), Expect = 3e-23
 Identities = 174/834 (20%), Positives = 354/834 (42%), Gaps = 114/834 (13%)

Query: 2    EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
            E+E  QKK+   K    +    + Q + +   + +K K+   S K+       L  + SQ
Sbjct: 640  ENELLQKKITNLKITCEKIEALE-QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698

Query: 62   CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
             +E  +   + VES       + +           Q  + ELESE             G 
Sbjct: 699  LDEENLELRRNVESLKCASMKMAQL----------QLENKELESEKEQLK-------KGL 741

Query: 122  SFVMRTGKPTNLLREEEFGVD--DSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELE 179
              +  + K T  L     G+D  +   ++  ++S   ++ +ESEL   + E + L + LE
Sbjct: 742  ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801

Query: 180  EMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQ 239
            E++++  ++ L+QL++   +++Q             Q  ++K +  +E   L +Q++   
Sbjct: 802  ELKIS--SKRLEQLEKENKSLEQ----------ETSQLEKDKKQLEKENKRLRQQAEIKD 849

Query: 240  IQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ-KKKEDFTMQI 298
               ++           + + + ++   K+  +  ++  +E   L++      K   T++ 
Sbjct: 850  TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909

Query: 299  SFLQEKIKVYEMEQD-KKVENS------NKEEIQEKETIIEELNTKIIEEE-----KKTL 346
              + EK+K  +M  D +K+ +       NKE +   E   ++   K++E +     KK+L
Sbjct: 910  DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL 969

Query: 347  ELK-DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQ 405
            E+K +K+   +  L E      Q  QE+K +K      KQ  RQ  E + Q    +    
Sbjct: 970  EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ--RQDEERMVQSSPPI---- 1023

Query: 406  KRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKT 465
              + +D+++E     R  QET R+L +++  L E             + ++ A ++  K 
Sbjct: 1024 --SGEDNKWE-----RESQETTRELLKVKDRLIE-------------VERNNATLQAEKQ 1063

Query: 466  RHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCA 525
              K +++      +N+      ++   V++ E N  LQ   +Q  KL+ E   +  +  +
Sbjct: 1064 ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ---TQNAKLQVENSTLNSQSTS 1120

Query: 526  LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL 585
            L  Q                   Q + +Q S  NE    +   EDLK+   S  +  ++L
Sbjct: 1121 LMNQ-----------------NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1163

Query: 586  ELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE 645
            EL HE + + Y+  +      K+A   +  E +  +LE    QLL   + +L  L++ L+
Sbjct: 1164 ELLHERQASEYESLISKHGTLKSA--HKNLEVEHRDLEDRYNQLL-KQKGQLEDLEKMLK 1220

Query: 646  IEHRINI--EKLKDNLGIHYKQ------QIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
            +E    +   K  + +   YK+      +++   +++ ++ E +Q +  NL +  N   L
Sbjct: 1221 VEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280

Query: 698  EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQ-----EEKEKGTLEQEVQELQLKT 752
            E ++L + + S +  + +++ +   +L  + E+L Q     EE+ +  L+Q +Q L L+ 
Sbjct: 1281 EQTRL-EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ-IQTLMLQN 1338

Query: 753  E-LLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE---DMLKIHTPVSQEER 802
              LLE+ M+ K+    E+   ++  N + + ++K  E   D  K + P     R
Sbjct: 1339 RTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1392



 Score =  101 bits (251), Expect = 2e-20
 Identities = 249/1188 (20%), Positives = 469/1188 (39%), Gaps = 260/1188 (21%)

Query: 2626 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES 2685
            K ++    + + EK ++LL+ ++ LE     Q E E KR  Q+   L     L  +    
Sbjct: 257  KAKIRRLRQELEEKTEQLLDCKQELE-----QMEIELKRLQQENMNL-----LSDARSAR 306

Query: 2686 GFFNELEALRAESVAT---KAELASYKEK----------AEKLQEELLVKETNMTSLQKD 2732
             + +EL+ALR ++V     ++E++ YKE+           E+L+E+  V     T L+  
Sbjct: 307  MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366

Query: 2733 LSQVR---DHLAEA-KEKLSILEKEDETEVQESKKACMFEPLP---IKLSKSIASQTDGT 2785
            L   R   D L E  KE L +  K  + E++        E L    + L  +     D +
Sbjct: 367  LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426

Query: 2786 L-------KISSSNQTPQILVKNAGIQIN-------LQSECSSEEVTEIISQFTEKIEKM 2831
            L       +IS +++  +   K+ G ++N       L+ E  ++ +T+ + +    ++ +
Sbjct: 427  LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486

Query: 2832 QELHAAEILDMESRH--------------ISETETLKREHYVAVQLLKEECGTLKAVIQC 2877
             E +A++IL ME  +              + E ++L+    ++  L+KE+   L+  I+ 
Sbjct: 487  -EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA-QLEKTIET 544

Query: 2878 LRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATD 2937
            LR      I  L   + +  + + S    S               I++E R ++ E    
Sbjct: 545  LRENSERQIKILEQENEHLNQTVSSLRQRSQ--------------ISAEARVKDIEKENK 590

Query: 2938 SFPKKIK---GLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT-ISS 2993
               + IK     L  +  E  Q+    E     GE     +     LE+    +   I++
Sbjct: 591  ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650

Query: 2994 LKDLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA 3051
            LK    K++   Q  +E+   ++  +   D    L   L+   LE+ +  L     EL  
Sbjct: 651  LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES--LEKENSQLDEENLELRR 708

Query: 3052 LGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR--RSLLSEIQALHAQMNGRKITLK 3109
                +++   +    ++Q +  E ++  E L+K     ++   + + L     G  I  +
Sbjct: 709  --NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766

Query: 3110 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ------EQLSSEKMVVAE 3163
            R Q++ + S +     IQQ +S++ ++++E  +++    EL+      EQL  E   + +
Sbjct: 767  RLQKTLENSNK----KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822

Query: 3164 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL--------NDTLASE-- 3213
              S+L + K +LE     ++K L++    + E+KD T E + +        N TL+ E  
Sbjct: 823  ETSQLEKDKKQLEK----ENKRLRQ----QAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874

Query: 3214 -QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ------- 3265
              K+S      LEKE  +L +    D + L  L+  L S+K +  Q+N  LE+       
Sbjct: 875  IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934

Query: 3266 ----QKQLLNESQQKIESQRMLYDAQLSEEQGRNLE--------LQVLLESE---KVRIR 3310
                +++LL++ Q   +S+  L +++L     ++LE        L+  LE       ++R
Sbjct: 935  IGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 994

Query: 3311 EMSSTLDRERELHAQLQSSDGTGQSRPPLPSED-------------LLKELQKQLE-EKH 3356
            +   T+ +  E   Q Q  +   QS PP+  ED             LLK   + +E E++
Sbjct: 995  QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN 1054

Query: 3357 SRIVELLNETEKYKLDSLQTR-----------QQMEKDRQVHRKTLQTE----------- 3394
            +  ++   +  K +L  L+T+           Q+     Q    TLQT+           
Sbjct: 1055 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1114

Query: 3395 ----------------QEANTEGQ-----KKMHELQSKVEDL-----------QRQLEE- 3421
                            Q+++ E +     K+  +L+S  + L           +RQ  E 
Sbjct: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY 1174

Query: 3422 --------------KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP 3467
                          K  +V   DLE +  Q + Q+ Q ++LE+  K E  ++L +N N  
Sbjct: 1175 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH- 1233

Query: 3468 TTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQ 3527
                                 ET  + Y KL    G     NH    + ++ + + +  +
Sbjct: 1234 ---------------------ETVAAEYKKLC---GENDRLNHTYSQLLKETEVLQTDHK 1269

Query: 3528 VLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ-----------QGEEPSLVS 3576
             L    +     +T  + +F  ++E   ++ +   KL  Q           + E   L+ 
Sbjct: 1270 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1329

Query: 3577 PSTSCGSLTERLLRQNAELTG--HIS--QLTEEKNDLRNMVMKLEEQI 3620
               +       LL QN E     H+   Q  ++ N+LR    KLEE+I
Sbjct: 1330 QIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377



 Score = 98.6 bits (244), Expect = 1e-19
 Identities = 249/1199 (20%), Positives = 508/1199 (42%), Gaps = 164/1199 (13%)

Query: 651  NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710
            +IE L  N+ +H K+ ID  ++E S+ I  +  E+D L    +      S          
Sbjct: 185  DIEPLLKNMALHLKRLIDE-RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT 243

Query: 711  NSKSEEMTLQINELQKEIEILRQEEKEKGT----LEQEVQELQLKTELLEKQMKEKENDL 766
             S+ + +++++ + + +I  LRQE +EK       +QE+++++++ + L+++     +D 
Sbjct: 244  ESR-QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302

Query: 767  QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEKEIEIL 825
            +   A++  +      EK    D  K+ + VS+ +ERL  ++  K++         +E L
Sbjct: 303  RS--ARMYRDELDALREKAVRVD--KLESEVSRYKERLHDIEFYKAR---------VEEL 349

Query: 826  IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885
             E+N+ L +    L +++E  R   + ++K  E+  + LQ        +K  L D + ++
Sbjct: 350  KEDNQVLLETKTMLEDQLEGTR---ARSDKLHELEKENLQ--------LKAKLHDMEMER 398

Query: 886  ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945
            +++ K   + + E + L+     ++  +S     +   ++ T E+ E  +K     + +L
Sbjct: 399  DMDRKKIEELMEENMTLEMAQKQSMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457

Query: 946  EVTKREKLEL-SQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH- 1003
              ++  KLE+ +Q L+   E+L+     +       K LK EKE   L  +++EI+ N  
Sbjct: 458  TSSRLLKLEMENQSLTKTVEELRTTVDSVE--GNASKILKMEKENQRLS-KKVEILENEI 514

Query: 1004 -NRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVG 1062
                +++Q+C      L+     +     E ++  + ++   + KI+ ++     N TV 
Sbjct: 515  VQEKQSLQNCQNLSKDLMKEKAQL-----EKTIETLRENSERQIKILEQENEHL-NQTVS 568

Query: 1063 EESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSL 1122
               ++ Q        ++ E+ ++  +  EN  L + +    S+ +  +++ E ++I   L
Sbjct: 569  SLRQRSQ--------ISAEARVKDIE-KENKILHESIKETSSKLS--KIEFEKRQIKKEL 617

Query: 1123 VYSTHVDQVREYMENE-----KDKALCSLKEELIFAQEEKIKEL-QKIHQLELQTMKTQE 1176
             +     +  E +ENE     K+  L   K   +    EKI+ L Q+  +LE +  K ++
Sbjct: 618  EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677

Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE 1236
            T D  K L   +  L+K  S+     L+   +V           ++  E+KE   +    
Sbjct: 678  TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737

Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN 1296
             +  EL    ++  +  E  +  L+   +   K   L+    KI   +++   LE   + 
Sbjct: 738  KKGLELLKASFKKTERLEVSYQGLDIENQRLQK--TLENSNKKIQQLESELQDLEMENQT 795

Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356
            L K             NLE++ ++ K +L  L+  E   LE++  +LE     L+++ K 
Sbjct: 796  LQK-------------NLEELKISSK-RLEQLEK-ENKSLEQETSQLEKDKKQLEKENKR 840

Query: 1357 TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK-KNID---- 1411
              Q  E +   L++    +       +L  ++  +++   +  +Y  SCV+ K ++    
Sbjct: 841  LRQQAEIKDTTLEENNVKIG------NLEKENKTLSK---EIGIYKESCVRLKELEKENK 891

Query: 1412 -----GTIEFSGEFGVKEETNIVKLLEKQYQEQLEE---EVAKVIVSMS--IAFAQQTEL 1461
                  TI+      ++E+    KL  +Q    LE+   E+ K+ ++    +   Q T+ 
Sbjct: 892  ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951

Query: 1462 SRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521
            SR    +    S+ +     ++E+    E +L +     Q         K+ ++ L +  
Sbjct: 952  SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011

Query: 1522 GEHGKEILLSNSDP---HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASR 1578
             E   E ++ +S P    D    ++   T  E +  KD+       I  E + +++ A +
Sbjct: 1012 DE---ERMVQSSPPISGEDNKWERESQETTRELLKVKDRL------IEVERNNATLQAEK 1062

Query: 1579 QLMLNE-EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQ- 1636
            Q +  + +QLE     L  Q    Q+ T  L++    Q    +    +LQ E   LN Q 
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQE----QNTTLQTQNAKLQVENSTLNSQS 1118

Query: 1637 ----------LAQRSSIDNEN--LVSERERV---------------LLEELEALKQLSL- 1668
                      L Q+SS++NEN  ++ ERE +               LL E +A +  SL 
Sbjct: 1119 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1178

Query: 1669 -------AGREKLCCELRNSSTQTQNGNENQGEVE--EQTFKEKELDRKPEDVPPEILSN 1719
                   +  + L  E R+   +     + +G++E  E+  K ++     E+   E ++ 
Sbjct: 1179 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1238

Query: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEAS 1778
            E   L   N+RL     +++K T  V +T  +++  +L+ S   Q+      R EAE S
Sbjct: 1239 EYKKLCGENDRLNHTYSQLLKET-EVLQTDHKNLKSLLNNSKLEQT------RLEAEFS 1290



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 169/742 (22%), Positives = 317/742 (42%), Gaps = 101/742 (13%)

Query: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060
            +Q Q++ E  +  Q  +   D +  +   +Q+V   + +V    +  E+T +   D   L
Sbjct: 133  VQCQKKEEFIERIQGLDF--DTKAAVAAHIQEVTHNQENVFDLQWM-EVTDMSQEDIEPL 189

Query: 3061 LNC----LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEK 3116
            L      L++ I E+    +  +E  ++ D    L    +  AQ       +KR +  + 
Sbjct: 190  LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASS-SAQSPCGSPGMKRTESRQH 248

Query: 3117 PSQEL---------LEYNIQQKQSQMLEMQVELSSMKDRATELQEQ-------------- 3153
             S EL         L   +++K  Q+L+ + EL  M+     LQ++              
Sbjct: 249  LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308

Query: 3154 ------LSSEKMVVAELKSELAQTKLELETT--LKAQHKHLKELEAFRLEVKDKTDEVHL 3205
                  L  + + V +L+SE+++ K  L      KA+ + LKE     LE K       +
Sbjct: 309  RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT------M 362

Query: 3206 LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL---NLL 3262
            L D L   + +S +L   LEKE  +L       K +L D++   +  +++  +L   N+ 
Sbjct: 363  LEDQLEGTRARSDKLH-ELEKENLQL-------KAKLHDMEMERDMDRKKIEELMEENMT 414

Query: 3263 LEQ-QKQLLNES-QQKIESQRMLYDAQLSEEQGRNL--ELQVLLESEKVRIREMSSTLDR 3318
            LE  QKQ ++ES     E +++   ++LSE   ++L  E+  L  S  +++   + +L +
Sbjct: 415  LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTK 474

Query: 3319 E-RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT- 3376
               EL   + S +G       +  E+  + L K++E   + IV+     EK  L + Q  
Sbjct: 475  TVEELRTTVDSVEGNASKILKMEKEN--QRLSKKVEILENEIVQ-----EKQSLQNCQNL 527

Query: 3377 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3436
             + + K++    KT++T +E N+E Q K+  L+ + E L + +   RQ+           
Sbjct: 528  SKDLMKEKAQLEKTIETLRE-NSERQIKI--LEQENEHLNQTVSSLRQR----------- 573

Query: 3437 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3496
              I  E + +++E+E K     IL++++ E T+  L+        +++++E   ++   A
Sbjct: 574  SQISAEARVKDIEKENK-----ILHESIKE-TSSKLSKIEFEKRQIKKELEHYKEKGERA 627

Query: 3497 KLIEMNGGGTGCNHELEMIRQK---LQCVASKLQVLPQKASERLQFETADDEDFIWVQEN 3553
            +  E+         E E++++K   L+    K++ L Q+ SE L+ E    +  +   +N
Sbjct: 628  E--ELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE-LERENRKLKKTLDSFKN 684

Query: 3554 IDEIILQLQKLTGQQGEEPSLVS---PSTSCGSL-TERLLRQNAELTGHISQLTEEKNDL 3609
            +   +  L+K   Q  EE   +     S  C S+   +L  +N EL     QL +    L
Sbjct: 685  LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744

Query: 3610 RNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRA 3669
            +    K E     Y+          +   N    I+  + SE +    E  TLQK+L+  
Sbjct: 745  KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ-LESELQDLEMENQTLQKNLEEL 803

Query: 3670 EAEVYKL-KAELRNDSLLQTLS 3690
            +    +L + E  N SL Q  S
Sbjct: 804  KISSKRLEQLEKENKSLEQETS 825


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  164 bits (415), Expect = 2e-39
 Identities = 307/1503 (20%), Positives = 616/1503 (40%), Gaps = 156/1503 (10%)

Query: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV------RELEQALLVS 2163
            ++ +L   L ++     EL L   + ++ + E++ +I  ++ R+       E + A  + 
Sbjct: 215  QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274

Query: 2164 ADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKN 2223
                +++ D+     +     L     L+ E+  +DRK   I  L E+      +L    
Sbjct: 275  PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRK---INQLSEENGDLSFKLREFA 331

Query: 2224 EEVQQLHMQLEIQKKESTTRLQE-LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGK 2282
              +QQL   L    +E +   QE LE++ +L K+    L  A+++   +  +++ +L GK
Sbjct: 332  SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE----LSAALQDKKCLEEKNE-ILQGK 386

Query: 2283 FAQII-----------QEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQI 2331
             +Q+            QEK   +  + +  T  Q+   +  +N  ++ + E++     Q 
Sbjct: 387  LSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQ 446

Query: 2332 ECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVV 2391
            E  +  +   + + EEE +QL+ +I  LQ  ++N+ Q       +       L  Q+  +
Sbjct: 447  EAKLLAE---RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503

Query: 2392 IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ-LTQELFSLKRERESVEKIQSIPENS 2450
             +E   L   ++  ++E+  +K   KE   ++ Q L Q+  + +  R  VE++ S     
Sbjct: 504  TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSS----- 558

Query: 2451 VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSA 2510
                   L + + +L+ V  +      ++     +  E  + S+   +  L QLE+    
Sbjct: 559  ------SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612

Query: 2511 KDLELTQCYKQIK---DMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY 2567
            K  +L    +Q++   + ++  Q      Q++   L + VEE    A V   + E  +  
Sbjct: 613  KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE--LQACVETARQEQHEAQ 670

Query: 2568 AKFCQDNQTISSEPERTNIQNLNQLREDELGSDISAL--TLRISELESQVVEMHTSLILE 2625
            A+  +    + SE ++   +      +D+L   + AL  +L++++   +  +   +  LE
Sbjct: 671  AQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE 730

Query: 2626 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQD-VEVLKTTTELFHSNEE 2684
            ++Q  I+E           E + L+E ++++++E E++R+ +  +E         H  E 
Sbjct: 731  EQQRCISELKA--------ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAET 782

Query: 2685 SGFFNEL-EALRAESVATKA------ELASYKEKAEKLQEE-----LLVKETNMTSLQKD 2732
                 EL EA+ A+  A         E+A+++E+ E  Q+E      + +E  MT L+++
Sbjct: 783  EVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT-LKEE 841

Query: 2733 LSQVRDHLAEAKEKLSILEKEDETEV--QESKKACMFEPLPI-------------KLSKS 2777
              + R  L EAKEK++ +E   E ++  Q+++ A +   L               KL+  
Sbjct: 842  CEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADD 901

Query: 2778 IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELH-- 2835
            +++  +     S      + LV+ AG Q    S    +E      +  E +E+ Q     
Sbjct: 902  LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFC 961

Query: 2836 ----AAEILDMESRHI-SETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELA 2890
                A + ++ E+  + +E E L+     +    +EE G  +  +  L  + G +  +LA
Sbjct: 962  STQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLA 1021

Query: 2891 HSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIA---SEGRGEESESATDSFPKKIKGL- 2946
               A +        +  +  +  + T  +    A    EG+ +E          +IK L 
Sbjct: 1022 LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE 1081

Query: 2947 -LRAVHNEGMQVLSLTESPYSDGEDHSIQQV--SEPWLEERKAYINTISSLKDLITKMQL 3003
             LR    +  + L+  E  ++ G     +    +EP   + +A    +S L+    K Q 
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141

Query: 3004 QREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNC 3063
            Q  A+  + S   E  S    +  L   Q  LEE++  L   ++ L +     A      
Sbjct: 1142 Q--ADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV 1199

Query: 3064 LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLE 3123
             +    E   + Q A    +   + SL+S ++   + +N R++  K  +  E     + E
Sbjct: 1200 QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN-RQVLEKEGESKELKRLVMAE 1258

Query: 3124 YNIQQKQSQMLEM-QVELSSMKDRATELQEQLSSEKMVVAEL--KSELAQTKLELETTLK 3180
                QK  + L + Q E +S   RA E    L  E   + E   K  +A   L  E T +
Sbjct: 1259 SEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQ 1318

Query: 3181 AQHKHL--KELEAFRLEVKDKTDEV------HLLNDTLASEQKKSRELQWALEKEKAKLG 3232
            A+      +EL+A++ +   K   +      H     L SE   ++ L   L+ E+A   
Sbjct: 1319 AERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAA-- 1376

Query: 3233 RSEERDKEELEDLKFSLESQK------QRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3286
             +E+R +EELE  K +    +      QR L   + L Q+      + Q++ +++  Y  
Sbjct: 1377 -AEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAE 1435

Query: 3287 QLS---------EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRP 3337
            QLS          E+ R L  +  L  + + +      LD+ RE + Q  ++        
Sbjct: 1436 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVE-----LDQAREKYVQELAAVRAD---- 1486

Query: 3338 PLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEA 3397
               +E  L E+Q++ +     +  +  + E  K+  L+ RQ+ +++RQ     ++  +  
Sbjct: 1487 ---AETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVF 1543

Query: 3398 NTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEG-------QRLQGIMQEFQKQELER 3450
              E  K++ EL  K+ D  +  + ++Q++  +  +G       QRLQ  + E Q Q  ++
Sbjct: 1544 QREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQK 1603

Query: 3451 EEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNH 3510
            E+  E     Y+   E       + + +N  LQ+++    +     K  E+        H
Sbjct: 1604 EQAAEH----YKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENK--ELRAEAERLGH 1657

Query: 3511 ELE 3513
            EL+
Sbjct: 1658 ELQ 1660



 Score =  147 bits (370), Expect = 3e-34
 Identities = 354/1816 (19%), Positives = 739/1816 (40%), Gaps = 291/1816 (16%)

Query: 613  RMAESQEAELERLRTQLLFSHEEELSKLKEDLE-IEHRINIEK-------LKDNLGIHYK 664
            ++ E  E EL ++ T LL  H    SK   D E  E++I  E        L    G++  
Sbjct: 86   KVLEGSELELAKM-TMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLN 144

Query: 665  QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
            + ++    +            + L    +Q   EI  L+   Q + +S S    L  +  
Sbjct: 145  EDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLE--LQKVASSSSGNNFLSGSPA 202

Query: 725  QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
                +IL+  + +   L++++ + +   + LE ++ E    L EK AQ+           
Sbjct: 203  SPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQI----------- 251

Query: 785  KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE-KEIEILIEENEDLK-------QQC 836
                           ++R+  L  +  K   S  E KE+E L ++NE L        +QC
Sbjct: 252  ------------AMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQC 299

Query: 837  IQLN-EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895
              L  E+ +  R     +E+N +++++    E+A  L+    L+D+ N+   E+    KA
Sbjct: 300  QDLKTEKSQMDRKINQLSEENGDLSFK--LREFASHLQ---QLQDALNELTEEHS---KA 351

Query: 896  LNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLEL 955
              E L  Q      ++ + S   +DK                   L EK E+ + +  +L
Sbjct: 352  TQEWLEKQ----AQLEKELSAALQDKKC-----------------LEEKNEILQGKLSQL 390

Query: 956  SQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 1015
             + LS L +   Q+ GE+     ++++LKQE                   A  + + +TQ
Sbjct: 391  EEHLSQLQDNPPQEKGEVLGDVLQLETLKQE-------------------AATLAANNTQ 431

Query: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK-----IMVEDKVSFENMTVGEESKQEQL 1070
            + + ++  +  T RG + +     +   EE K     ++ + + S  N++  +E  ++  
Sbjct: 432  LQARVE--MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQAS 489

Query: 1071 ------ILDHLPSVTKE-SSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLV 1123
                  +   + S+T E ++L AT   ++ +L       K +Q  L   ++ Q       
Sbjct: 490  QAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQ------- 542

Query: 1124 YSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQ-ETGDEGK 1182
                 +Q  + + ++ ++   SLK++     E+++KE+ +  +   Q    Q  T  E +
Sbjct: 543  -----EQASQGLRHQVEQLSSSLKQK-----EQQLKEVAEKQEATRQDHAQQLATAAEER 592

Query: 1183 PLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPEL 1242
               L   + + A  ++     +   + L E     L+    A D   +    ++ E  EL
Sbjct: 593  EASL---RERDAALKQLEALEKEKAAKL-EILQQQLQVANEARDSAQTSVTQAQREKAEL 648

Query: 1243 QDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEET 1302
                 +V++ Q  + T   +  E   ++  L+ +L     + T+  ++   ++ L +E+ 
Sbjct: 649  SR---KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL-QEQL 704

Query: 1303 EFLSIHSQMT--NLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQN 1360
            + L    ++T  +LE+     K + +   + ++  + E   E  SL+   +++ KE E+ 
Sbjct: 705  QALKESLKVTKGSLEE----EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760

Query: 1361 YEAEIHCLQKRLQAVSESTVPPSLPVDSVVI--------TESDAQRTMYPGSCVKKNIDG 1412
              A    L+ RLQ + E+    +  +   +          ES+ ++ +   +  ++  + 
Sbjct: 761  -RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819

Query: 1413 TIEFSGEFGVKEETNIVKLLE-----KQYQEQLEEEVAKVIVSMSIAFA-QQTELSRISG 1466
            + +   ++G   +  ++ L E     +Q  ++ +E+VA +     +  + QQ EL+ +  
Sbjct: 820  SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH- 878

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
                   +  A A+ Q ++      KL+ D    Q       K     + L ++ GE  +
Sbjct: 879  -------ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE--Q 929

Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
            +   S     +   + D      EE          RQ    + ++ +M+   + M NE  
Sbjct: 930  QETASRELVKEPARAGDRQPEWLEEQQG-------RQFCSTQAALQAMEREAEQMGNE-- 980

Query: 1587 LEDMRQELVR-QYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDN 1645
            LE +R  L+  Q Q+ ++  +  R+      ER R   +   E+  R   ++  +++++ 
Sbjct: 981  LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040

Query: 1646 ENL------------VSERE-------------RVLLEELEALKQLSLAGREKLCCELRN 1680
            + +            ++E+E                ++ELE L+Q     +E+L  + + 
Sbjct: 1041 QRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100

Query: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
             ++ +   +E  G  E    K + L  +   +  +    +  A        L+  LE  +
Sbjct: 1101 HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADS------LERSLEAER 1154

Query: 1741 TTAAVEETIGRHVLGILDRSSKSQS-SASLIWRSEAEASVKSCVHEEHTRVTDESIPSYS 1799
             + A  ++    + G L+  ++    S S +  ++ E +      ++H++  DE     +
Sbjct: 1155 ASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVA 1214

Query: 1800 -GSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858
             G        ++ S + EE + L+++++       E+    + L++  S + Q   E+L 
Sbjct: 1215 RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL----KRLVMAESEKSQKLEERLR 1270

Query: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS 1918
               +ET+S    A    + L  E    ++EA +     E LR+ L  ++   E+L  EL 
Sbjct: 1271 LLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELK 1330

Query: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE-RELLS 1977
              +     +  E+ L   Q++  +     L  ELL A +  Q+L+AEQ   ++  RE L 
Sbjct: 1331 AWQEKF--FQKEQALSTLQLEHTST--QALVSELLPAKHLCQQLQAEQAAAEKRHREELE 1386

Query: 1978 RQKEAMKAEAGPVEQQLLQETEKL-----------MKEKLEVQCQAEKV----------- 2015
            + K+A    AG +  +LL+   +L            +E+   Q +AEK            
Sbjct: 1387 QSKQA----AGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK 1442

Query: 2016 --------------RDDLQKQVKALEIDV--EEQVSRFIELEQEKNTELMDLRQQNQALE 2059
                          R +L +Q   +E+D   E+ V     +  +  T L +++++ Q+  
Sbjct: 1443 AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTA 1502

Query: 2060 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK 2119
            ++LE M    +   +    ER  FQ+E QKL  Q++ +  FQ     QT++VE+L+  L 
Sbjct: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQ---REQTKQVEELSKKLA 1559

Query: 2120 EKTDKCSELLLSK-EQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGA 2178
            + +D+ S++   K + +Q    E  +E ++L+ ++ EL+      A   QK +  +H+  
Sbjct: 1560 D-SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ------AQLSQKEQAAEHY-- 1610

Query: 2179 VEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK 2238
                     ++Q++  +   D K+++   L+EQL    E+L+ +N+E++    +L  + +
Sbjct: 1611 ---------KLQMEKAKTHYDAKKQQNQELQEQLRSL-EQLQKENKELRAEAERLGHELQ 1660

Query: 2239 ESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2298
            ++  + +E EQ  +     +  L   +  +D           GKF       +V  D L 
Sbjct: 1661 QAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRD-----LGKF-------QVATDALK 1708

Query: 2299 EQVTKLQQQLKITTDN 2314
             +  + + QL ++ D+
Sbjct: 1709 SREPQAKPQLDLSIDS 1724



 Score =  142 bits (357), Expect = 8e-33
 Identities = 254/1280 (19%), Positives = 520/1280 (40%), Gaps = 161/1280 (12%)

Query: 147  EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
            EQ +Q     +E + S L  K+ +++E+  + E  R  +  +     +E EA++++RD  
Sbjct: 543  EQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAA 602

Query: 207  ITQLTA--------------NLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETL 251
            + QL A               LQ A   +D       +   +  +L  + ++LQA  ET 
Sbjct: 603  LKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETA 662

Query: 252  RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE-- 309
            R   H +  A + + + Q+ + QQ+  E++ + ++    K+    Q+  L+E +KV +  
Sbjct: 663  RQEQHEA-QAQVAELELQLRSEQQKATEKERVAQE----KDQLQEQLQALKESLKVTKGS 717

Query: 310  MEQDKKVENSNKEEIQEKETIIEELNTK---IIEEEKK-TLELKDKLTTADKLLGELQEQ 365
            +E++K+      + ++E++  I EL  +   ++E+ K+   EL+++      L   LQ+ 
Sbjct: 718  LEEEKR---RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL 774

Query: 366  IVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425
                  E + ++ EL  +   +  +  E +QL+  V   ++R ++DSQ            
Sbjct: 775  GEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER-YEDSQ------------ 821

Query: 426  TQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNE 485
                  Q  A+   M+ +Q++ +K+E  +    +++E K +  G     + S+S + ++ 
Sbjct: 822  ------QEEAQYGAMFQEQLMTLKEECEKARQ-ELQEAKEKVAG-----IESHSELQISR 869

Query: 486  DQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQ 545
             Q +L  +  N               L   L  + E++   Q+    L ++LS  +E++ 
Sbjct: 870  QQNELAELHAN---------------LARALQQVQEKEVRAQK----LADDLSTLQEKMA 910

Query: 546  RARQTIAEQESKLNEAHKSLSTV-EDLKAEIVSASESRKE-LELKHEAEVTNYKIKLEML 603
               + +A  E+ + +A +   T   +L  E   A + + E LE +   +  + +  L+ +
Sbjct: 911  ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAM 970

Query: 604  EKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEK--------L 655
            E+E        AE    ELERLR  L+ S  ++  +  +      R+  E+        L
Sbjct: 971  ERE--------AEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLAL 1022

Query: 656  KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715
            +       + ++    NE   +  T+Q    + +T++     E++KL+ L+ + +  + E
Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQI-KELE 1081

Query: 716  EMTLQINELQKEIEILRQEEKEKGTLEQE-----------VQELQLKTELLEKQMKEKEN 764
            E+   + +L++++    +E       + E           ++ L+ +   LE+Q ++++ 
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141

Query: 765  DLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824
                    LEAE +   +    LE +       +QE          ++ + + +  +++ 
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201

Query: 825  LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV-NYQELQEEYACLLKVKDDLEDSKN 883
              +  ++ K Q  +  +E E++ +  S  E+   + N Q L++E       +  + +S+ 
Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEK 1261

Query: 884  KQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELME 943
             Q+LE   +L+ L  E      N      +SS   E+   + E  E   V  ++   L +
Sbjct: 1262 SQKLE--ERLRLLQAE---TASNSARAAERSSALREEVQSLREEAEKQRVASEN---LRQ 1313

Query: 944  KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEE---VKSLKQEKEQVSLRCRELEII 1000
            +L        EL Q L    E+  QK   +S L  E    ++L  E       C++L+  
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQ-- 1371

Query: 1001 INHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMT 1060
                 AE     + + S    G       G    + +  +  GE   I +  KV+ +  T
Sbjct: 1372 AEQAAAEKRHREELEQSKQAAG-------GLRAELLRAQRELGE--LIPLRQKVAEQERT 1422

Query: 1061 VGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV----LKSEQNDLRLQMEAQ 1116
              +   ++    + L  + K   L A    EN  L +  N+    L+ E +  R +   +
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLA---EENRGLGERANLGRQFLEVELDQAREKYVQE 1479

Query: 1117 RICLSLVYSTHVDQVR----------EYMENEKDKALCSLKEELIFAQEEKIKELQKIHQ 1166
               +     T + +V+          E M  + + A   + EE    QEE+ K   ++ Q
Sbjct: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539

Query: 1167 LEL----QTMKTQE------TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTP 1216
            LE+    QT + +E        D+   +     K  +A   E     Q L + L E    
Sbjct: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599

Query: 1217 ALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR 1276
              + E  AE  +   +    + D + Q    + Q+ QE + + L ++ +E  +L     R
Sbjct: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQ----QNQELQEQLRS-LEQLQKENKELRAEAER 1654

Query: 1277 LSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKL 1336
            L      Q  G+K +  E+       +  S+ +Q+ +  D  +    K     D  K++ 
Sbjct: 1655 LGH--ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAH-ADQQLRDLGKFQVATDALKSRE 1711

Query: 1337 EEQVQELESLISSLQQQLKE 1356
             +   +L+  I SL    +E
Sbjct: 1712 PQAKPQLDLSIDSLDLSCEE 1731



 Score =  138 bits (348), Expect = 9e-32
 Identities = 309/1491 (20%), Positives = 618/1491 (41%), Gaps = 187/1491 (12%)

Query: 1855 EKLLEAISETSSQLEHAKVTQTELMRE-----------SFRQKQEATESLKCQEELRERL 1903
            E L   + ET  Q +  K  ++++ R+           SF+ ++ A+   + Q+ L E  
Sbjct: 286  ESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELT 345

Query: 1904 HEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ------------- 1950
             E S+A ++   + ++ E  +     +K   E + +     + +LE+             
Sbjct: 346  EEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEK 405

Query: 1951 -ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQ 2009
             E+L    +L+ L+ E   +      L  + E ++ E G  E +LL E     +EK    
Sbjct: 406  GEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQ--- 462

Query: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
             Q   +  DLQ  +  L    EE       LEQ        L  Q  +L  +L  +   +
Sbjct: 463  -QLSSLITDLQSSISNLSQAKEE-------LEQASQAHGARLTAQVASLTSELTTLNATI 514

Query: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
             +Q  D+E    + QQ  +K  Q  + + + +  S+    +VEQL++ LK+K  +  E+ 
Sbjct: 515  QQQ--DQELA-GLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571

Query: 2130 LSKEQLQRD--------IQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
              +E  ++D         +ER   + + +  +++LE      A   + ++ +    A EA
Sbjct: 572  EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQV-ANEA 630

Query: 2182 KPELSLEV-QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKES 2240
            +      V Q Q E+  + RK +E   L+  +E  R+E      +V +L +QL  +++++
Sbjct: 631  RDSAQTSVTQAQREKAELSRKVEE---LQACVETARQEQHEAQAQVAELELQLRSEQQKA 687

Query: 2241 TTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2300
            T + + + QE    KD +++   A+KES  ++         + A  ++E++  I +L  +
Sbjct: 688  TEK-ERVAQE----KDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742

Query: 2301 VTKLQQQLKITTDNKVIEEKNELIRDLETQIECL--------------MSDQECVKRNRE 2346
               L +Q K   + K +EE+    + LE +++ L              +++    +   E
Sbjct: 743  TRSLVEQHK--RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE 800

Query: 2347 EEIEQL-------NEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2399
             E EQL        E  E  QQE A  G        +L EE +  + +L     +   +E
Sbjct: 801  SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860

Query: 2400 QQVETA-----NEEMTFMKNV------LKETNFKMNQLTQELFSLKRERESVEKIQSIPE 2448
               E       NE      N+      ++E   +  +L  +L +L+ +  +  K  +  E
Sbjct: 861  SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE 920

Query: 2449 NSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTV 2508
              V  A +       EL     ++  ++ + Q  +   EE       + +  L  +E   
Sbjct: 921  TLVRKAGEQQETASREL----VKEPARAGDRQPEW--LEEQQGRQFCSTQAALQAMEREA 974

Query: 2509 SAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQK---------IVEEKVAAALVSQI 2559
                 EL +    + + Q Q Q E    ++++  L +          +E+   A L  ++
Sbjct: 975  EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRL 1034

Query: 2560 QLEAVQEYAKFCQDNQTIS---SEPERTNIQNLNQLREDELGS--DISALTLRISELESQ 2614
            Q    ++  +F    + ++   +E E  + Q L +LR  E     ++  L   + +L+ Q
Sbjct: 1035 QNALNEQRVEFATLQEALAHALTEKEGKD-QELAKLRGLEAAQIKELEELRQTVKQLKEQ 1093

Query: 2615 VVEMH-------------------TSLILEKEQVEIA--EKNVLEKEKKLLELQKLLEGN 2653
            + +                     T   LE  + E++  E+   +++++   L++ LE  
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAE 1153

Query: 2654 EKKQREKEKKRSPQDVEVLKTTTELFHSNEE-SGFFNELEALRAESVATKAELASYKEKA 2712
               + E++        ++ +   EL HS    +    EL A R +          +K + 
Sbjct: 1154 RASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV 1213

Query: 2713 EKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPI 2772
             + ++E   K + ++SL++++S +   + E + +   L++    E ++S+K  + E L +
Sbjct: 1214 ARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQK--LEERLRL 1271

Query: 2773 KLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKM- 2831
              +++ ++      + S+  +  Q L + A  Q       +SE + + ++   E+ E++ 
Sbjct: 1272 LQAETASNSARAAERSSALREEVQSLREEAEKQ-----RVASENLRQELTSQAERAEELG 1326

Query: 2832 QELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAH 2891
            QEL A +    +        TL+ EH  + Q L  E    K + Q L++++ ++  E  H
Sbjct: 1327 QELKAWQEKFFQKEQA--LSTLQLEH-TSTQALVSELLPAKHLCQQLQAEQAAA--EKRH 1381

Query: 2892 SDAYQTREICSSD-------SGSDWGQGIYLTH--SQGFDIASEGRGEESESATD-SFPK 2941
             +  +  +  +         +  + G+ I L    ++    A + R E++  A   S  K
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441

Query: 2942 KIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-QQVSEPWLEE-RKAYINTISSLK-DLI 2998
            K  GLL A  N G+            GE  ++ +Q  E  L++ R+ Y+  +++++ D  
Sbjct: 1442 KAHGLL-AEENRGL------------GERANLGRQFLEVELDQAREKYVQELAAVRADAE 1488

Query: 2999 TKM-QLQREAEVYDSSQSHESFSDWRGELLLALQ--QVFLEERSVLLAAF-RTELTALGT 3054
            T++ ++QREA+   + +     + + G  +  L+  Q F EER  L A   + E+     
Sbjct: 1489 TRLAEVQREAQS-TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547

Query: 3055 TDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITL-KREQE 3113
            T  V  L+       +     Q  ++ +Q     S   E Q L AQ+N  +  L ++EQ 
Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQ-QEAQRLQAQLNELQAQLSQKEQA 1606

Query: 3114 SE--KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3171
            +E  K   E  + +   K+ Q  E+Q +L S++    E +E  +  + +  EL+    +T
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKT 1666

Query: 3172 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLND-TLASEQKKSRELQ 3221
            K E E T +     ++ LEA   +V     ++  L    +A++  KSRE Q
Sbjct: 1667 K-EAEQTCRHLTAQVRSLEA---QVAHADQQLRDLGKFQVATDALKSREPQ 1713



 Score =  138 bits (348), Expect = 9e-32
 Identities = 289/1400 (20%), Positives = 554/1400 (39%), Gaps = 189/1400 (13%)

Query: 134  LREEEFGVDDSYSEQGAQDSPTHLEMME--SELAGKQHEIEELNRELEEMRVTYGTEGLQ 191
            L+ E+  +D   ++   ++     ++ E  S L   Q  + EL  E  +    +  +  Q
Sbjct: 302  LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ 361

Query: 192  QLQEFEAAIKQR----------DGIITQLTANLQQAR----REKDETMREFLELTEQSQK 237
              +E  AA++ +           G ++QL  +L Q +    +EK E + + L+L    Q+
Sbjct: 362  LEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421

Query: 238  ---LQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDF 294
               L     QLQA   +  +      A LL  +      +QQL     L+ D Q    + 
Sbjct: 422  AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSS---LITDLQSSISNL 478

Query: 295  TMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIE---ELNTKIIEEEKKTLELKDK 351
            +     L++  + +      +V +   E      TI +   EL     + ++K  +L   
Sbjct: 479  SQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT 538

Query: 352  LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKD 411
            L   ++    L+ Q+ Q +  +K  + +L    +K+  + ++  Q + T  E ++ + ++
Sbjct: 539  LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRE 598

Query: 412  SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEM 471
                   ++ +E+E   KLE L+ +L      Q+    ++  +  + Q +  K     ++
Sbjct: 599  RDAALKQLEALEKEKAAKLEILQQQL------QVANEARDSAQTSVTQAQREKAELSRKV 652

Query: 472  ENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE 531
            E  L++       E       VA  EL ++   +  QK   KE    + +EK  LQ QL+
Sbjct: 653  EE-LQACVETARQEQHEAQAQVAELELQLR---SEQQKATEKER---VAQEKDQLQEQLQ 705

Query: 532  DLVEELSFSR----EQIQRARQTIAEQESKLNEAH-KSLSTVEDLKAEIVSASE---SRK 583
             L E L  ++    E+ +RA   + EQ+  ++E   ++ S VE  K E     E    RK
Sbjct: 706  ALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRK 765

Query: 584  ELELK-------HEAEVTNYKIKL--------------EMLEKEKNAVLDRMAESQEAEL 622
             LE +       H+AE    + +L              E L KE  A  +R  +SQ+ E 
Sbjct: 766  GLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEE- 824

Query: 623  ERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNL-GI--HYKQQIDGLQNEMS---- 675
                 Q     +E+L  LKE+ E + R  +++ K+ + GI  H + QI   QNE++    
Sbjct: 825  ----AQYGAMFQEQLMTLKEECE-KARQELQEAKEKVAGIESHSELQISRQQNELAELHA 879

Query: 676  ----------QKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ 725
                      +K    Q   D+L T Q ++     ++  L ++LV    E+      EL 
Sbjct: 880  NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARL-ETLVRKAGEQQETASRELV 938

Query: 726  KE--------IEILRQEEKEK--------GTLEQEVQELQLKTELLEKQMKEKENDLQEK 769
            KE         E L +++  +          +E+E +++  + E L   + E +   QE+
Sbjct: 939  KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE 998

Query: 770  FAQLEAENSILKDEK----------KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE 819
              Q E E + L  E+          K     L++    +  E+ +   +++     ++ E
Sbjct: 999  RGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTE 1058

Query: 820  KEIE------------ILIEENEDLKQQCIQLNEEI---EKQRNTFSFAEKNFEVNYQEL 864
            KE +              I+E E+L+Q   QL E++   EK+  + S A+       +  
Sbjct: 1059 KEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPT 1118

Query: 865  QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFV 924
              +   L      LE    KQ+ +  S  ++L  E   +    + ++      +E    +
Sbjct: 1119 GPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQEL 1178

Query: 925  AETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984
              +       +++      K++   + + E   +++   ++ ++K+  IS L EEV  L 
Sbjct: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238

Query: 985  QEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGE 1044
            ++  +     +EL+ ++    +E  Q  + ++  L     + ++R AE S      +  E
Sbjct: 1239 RQVLEKEGESKELKRLV-MAESEKSQKLEERLRLLQAETASNSARAAERS-----SALRE 1292

Query: 1045 ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104
            E + + E+    E   V  E+ +++L      +      L+A Q     K ++ L+ L+ 
Sbjct: 1293 EVQSLREEA---EKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQK-EQALSTLQL 1348

Query: 1105 EQNDLRL----QMEAQRICLSLVYSTHVDQVREYMENEKDK-ALCSLKEELIFAQEE--- 1156
            E    +      + A+ +C  L       + R   E E+ K A   L+ EL+ AQ E   
Sbjct: 1349 EHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGE 1408

Query: 1157 ------KIKELQK-IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS---YFLQTL 1206
                  K+ E ++   QL  +     E     K  H L+ +  + + E  +    FL+  
Sbjct: 1409 LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVE 1468

Query: 1207 CSVLGEYYT---PALKCEVNAEDKENSGDYISENEDPELQDYRY---------EVQDFQE 1254
                 E Y     A++ +      E   +  S   + E+   +Y         E Q FQE
Sbjct: 1469 LDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528

Query: 1255 NMHTLL-------------NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE--ENLPK 1299
                L               K  EE +K L    + SK+  Q+   ++ + GE  +   +
Sbjct: 1529 ERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQR 1588

Query: 1300 EETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQ 1359
             + +   + +Q++  E    ++K ++   +     K ++Q QEL+  + SL+Q  KE ++
Sbjct: 1589 LQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK-KQQNQELQEQLRSLEQLQKENKE 1647

Query: 1360 NYEAEIHCLQKRLQAVSEST 1379
               AE   L   LQ     T
Sbjct: 1648 -LRAEAERLGHELQQAGLKT 1666



 Score =  132 bits (333), Expect = 5e-30
 Identities = 330/1674 (19%), Positives = 665/1674 (39%), Gaps = 244/1674 (14%)

Query: 350  DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409
            D L T    +  L++Q+  +      ++LEL  +++   +   +I  +   ++ L   N 
Sbjct: 207  DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE 266

Query: 410  KDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKG 469
            K  Q  + +  +  +E + K E L   L E   +Q   +K E  +  M +     +   G
Sbjct: 267  K--QAASPLEPKELEELRDKNESLTMRLHETL-KQCQDLKTE--KSQMDRKINQLSEENG 321

Query: 470  EMENALRSYSNITVNEDQIKLMNVAINELNIK----LQDTNSQKEKLKEELGLILEEKCA 525
            ++   LR +++       ++ +  A+NEL  +     Q+   ++ +L++EL   L++K  
Sbjct: 322  DLSFKLREFAS------HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC 375

Query: 526  LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL 585
            L+ + E L  +LS   E + + +    +++    E    +  +E LK E  + + +  +L
Sbjct: 376  LEEKNEILQGKLSQLEEHLSQLQDNPPQEK---GEVLGDVLQLETLKQEAATLAANNTQL 432

Query: 586  ELKHEAEVTNYKIKLEMLEKEKNAVLDR-MAESQEAELERLRTQLLFSHEEELSKLKEDL 644
            + + E       ++ E  ++E   + +R   E ++ +L  L T L  S    LS+ KE+L
Sbjct: 433  QARVE------MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQ-SSISNLSQAKEEL 485

Query: 645  EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLI-------TKQNQLIL 697
            E   + +        G     Q+  L +E++    T+Q +   L         KQ QL  
Sbjct: 486  EQASQAH--------GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQ 537

Query: 698  EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757
             + + +   Q L   + E+++  +   QKE ++    EK++ T +   Q+L    E  E 
Sbjct: 538  TLQQQEQASQGL-RHQVEQLSSSLK--QKEQQLKEVAEKQEATRQDHAQQLATAAEEREA 594

Query: 758  QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSV 817
             ++E++  L+    QLEA       + + L+  L++        +     + + K++ S 
Sbjct: 595  SLRERDAALK----QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650

Query: 818  WEKEIEILIE----ENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL-- 871
              +E++  +E    E  + + Q  +L  ++  ++   +  E+  +    +LQE+   L  
Sbjct: 651  KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQ-EKDQLQEQLQALKE 709

Query: 872  -LKV-KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED----KTFVA 925
             LKV K  LE+ K +     + + + ++E     R      K +    +E+    K   A
Sbjct: 710  SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769

Query: 926  ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
               ++GE  + +T       EV +RE  E          + +Q   E++   E  +  +Q
Sbjct: 770  RLQQLGEAHQAET-------EVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822

Query: 986  EKEQVSLRCRELEIIIN---HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF 1042
            E+ Q     +E  + +        + +Q    +V+ +        SR  +  +++++ + 
Sbjct: 823  EEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISR-QQNELAELHANL 881

Query: 1043 GEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT---QPSENDKLQKEL 1099
                + + E +V  + +     + QE++          E+ +R     Q + + +L KE 
Sbjct: 882  ARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEP 941

Query: 1100 NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIK 1159
                  Q +   + + ++ C +      +++  E M NE ++   +L E     QEE+ +
Sbjct: 942  ARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQ 1001

Query: 1160 ELQKIHQLELQTMKTQETGDEGKPLHL-------LIGKLQKAVSEECSYFLQTLCSVLGE 1212
            + +++ +L      TQE G     L L       L  +LQ A++E+   F  TL   L  
Sbjct: 1002 QEREVARL------TQERGRAQADLALEKAARAELEMRLQNALNEQRVEF-ATLQEALAH 1054

Query: 1213 YYTPALKCEVNAEDKENSG-DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL 1271
              T     E   +D+E +    +   +  EL++ R  V+  +E     L K  +E+    
Sbjct: 1055 ALT-----EKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQ----LAKKEKEHASGS 1105

Query: 1272 VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLE-DIDVNHKSKLSSLQD 1330
              Q+  +     +  G KLE     + K E +      Q  +LE  ++    S+      
Sbjct: 1106 GAQSEAA--GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSA 1163

Query: 1331 LE--KTKLEEQVQEL---ESLISSLQQQL----------KETEQNYEAEIHCLQKRLQAV 1375
            LE  + +LEE+ QEL   +S ++S Q++L           + E  ++A++   + R +A 
Sbjct: 1164 LETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV--ARGRQEAE 1221

Query: 1376 SESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQ 1435
             ++++  SL  +  ++                      +E  GE    +E   + + E +
Sbjct: 1222 RKNSLISSLEEEVSILNRQ------------------VLEKEGE---SKELKRLVMAESE 1260

Query: 1436 YQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQ 1495
              ++LEE +  +          Q E +       N+A + +  +  ++E     E    Q
Sbjct: 1261 KSQKLEERLRLL----------QAETA------SNSARAAERSSALREEVQSLREEAEKQ 1304

Query: 1496 DQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSK 1555
                           ++E    ++   E G+E+                     E+ F K
Sbjct: 1305 --------RVASENLRQELTSQAERAEELGQEL-----------------KAWQEKFFQK 1339

Query: 1556 DKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQ 1615
            ++     Q  H          S Q +++E       + L +Q Q  Q A E   + H  +
Sbjct: 1340 EQALSTLQLEH---------TSTQALVSELL---PAKHLCQQLQAEQAAAE---KRHREE 1384

Query: 1616 MERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLC 1675
            +E+ ++    L+ E+ R  R+L +   I     V+E+ER   ++L A ++ S A +  + 
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGE--LIPLRQKVAEQERT-AQQLRA-EKASYAEQLSML 1440

Query: 1676 CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735
             +      +   G   +  +  Q F E ELD+  E    E+ +        A  RL ++ 
Sbjct: 1441 KKAHGLLAEENRGLGERANLGRQ-FLEVELDQAREKYVQELAA----VRADAETRLAEVQ 1495

Query: 1736 LEVVKTTAAVEETIGRH---VLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD 1792
             E   T   +E    ++    + +L+   + Q       +  A+         E T+  +
Sbjct: 1496 REAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQ---KLTAQVEQLEVFQREQTKQVE 1552

Query: 1793 ESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQA 1852
            E     + SD         SKV +      Q+L      G E   E        + RLQA
Sbjct: 1553 ELSKKLADSDQA-------SKVQQ------QKLKAVQAQGGESQQE--------AQRLQA 1591

Query: 1853 AVEKLLEAISETSSQLEHAKVTQTELMRESF----RQKQEATESLKCQEELRERLHEESR 1908
             + +L   +S+     EH K+ Q E  +  +    +Q QE  E L+  E+L++   E   
Sbjct: 1592 QLNELQAQLSQKEQAAEHYKL-QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA 1650

Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL 1962
              E+L  EL +A     G   ++   E+  +  T  +  LE ++  A  +L++L
Sbjct: 1651 EAERLGHELQQA-----GLKTKEA--EQTCRHLTAQVRSLEAQVAHADQQLRDL 1697



 Score = 72.8 bits (177), Expect = 6e-12
 Identities = 137/650 (21%), Positives = 270/650 (41%), Gaps = 96/650 (14%)

Query: 3074 EYQAAMECLQKADRRSLLSEIQALHAQMNG----RKITLKREQESEKPSQELLEYNIQQK 3129
            E+ + ++ LQ A     L+E+   H++       ++  L++E  +    ++ LE   +  
Sbjct: 329  EFASHLQQLQDA-----LNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEIL 383

Query: 3130 QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA---------QTKLELETTLK 3180
            Q ++ +++  LS ++D   + + ++  + + +  LK E A         Q ++E+  T +
Sbjct: 384  QGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETER 443

Query: 3181 AQH--KHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD 3238
             Q   K L E   F  E +  +  +  L  ++++  +   EL+ A +   A+L       
Sbjct: 444  GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503

Query: 3239 KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLE- 3297
              EL  L  +++ Q Q        L   KQ   E Q ++ +Q +    Q S+     +E 
Sbjct: 504  TSELTTLNATIQQQDQE-------LAGLKQQAKEKQAQL-AQTLQQQEQASQGLRHQVEQ 555

Query: 3298 LQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
            L   L+ ++ +++E++   +  R+ HAQ  ++                +E +  L E+ +
Sbjct: 556  LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAA--------------EEREASLRERDA 601

Query: 3358 RIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQR 3417
             + +L    EK K   L+  QQ     QV  +   + Q + T+ Q++  EL  KVE+LQ 
Sbjct: 602  ALKQL-EALEKEKAAKLEILQQQ---LQVANEARDSAQTSVTQAQREKAELSRKVEELQA 657

Query: 3418 QLEEKRQ-------QVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTW 3470
             +E  RQ       QV +L+L+ +  Q    E ++   E+++ +E  + L ++L + T  
Sbjct: 658  CVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESL-KVTKG 716

Query: 3471 SLTSDRTR---------NWVLQQKIEG----ETKESNYAKLIEMNGGGTGCNHELEMIRQ 3517
            SL  ++ R           + + K E     E  +    +L E   G  G    L+ + +
Sbjct: 717  SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGE 776

Query: 3518 KLQCVASKLQVLPQKASERLQFE-TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVS 3576
              Q   ++ +VL ++ +E +  + TA+ E     ++ + E+    ++    Q EE    +
Sbjct: 777  AHQ---AETEVLRRELAEAMAAQHTAESE----CEQLVKEVAAWRERYEDSQQEEAQYGA 829

Query: 3577 PSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRF 3636
                     E+L+    E      +L E K  +  +    E QI         R  +   
Sbjct: 830  ------MFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQI--------SRQQNELA 875

Query: 3637 SLNGGANIEAIIASEKEVWNREKL-----TLQKSLKRAEAEVYKLKAELR 3681
             L+           EKEV   +KL     TLQ+ +     EV +L+  +R
Sbjct: 876  ELHANLARALQQVQEKEV-RAQKLADDLSTLQEKMAATSKEVARLETLVR 924



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 109/535 (20%), Positives = 231/535 (43%), Gaps = 62/535 (11%)

Query: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK-S 3166
            LK++   E+ +++ LE  + + +  + E   +++ M+ R   L   L +EK   + L+  
Sbjct: 219  LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA--LLNEKQAASPLEPK 276

Query: 3167 ELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK 3226
            EL + + + E+     H+ LK+ +  + E      +++ L++       K RE    L++
Sbjct: 277  ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336

Query: 3227 EKAKLGR-SEERDK--EELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3283
             +  L   +EE  K  +E  + +  LE +    LQ    LE++ ++L     ++E     
Sbjct: 337  LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396

Query: 3284 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSD-GTGQSRPPLPSE 3342
                  +E+G  L   + LE+ K   +E ++      +L A+++  +   GQ    L +E
Sbjct: 397  LQDNPPQEKGEVLGDVLQLETLK---QEAATLAANNTQLQARVEMLETERGQQEAKLLAE 453

Query: 3343 DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVH--RKTLQ-------- 3392
                  +   EE+  ++  L+ + +    +  Q ++++E+  Q H  R T Q        
Sbjct: 454  ------RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSEL 507

Query: 3393 -----TEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE 3447
                 T Q+ + E      + + K   L + L+++ Q    L  + ++L   +++ ++Q 
Sbjct: 508  TTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL 567

Query: 3448 LEREEKRESRRILY-QNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT 3506
             E  EK+E+ R  + Q L         S R R+  L+Q +E   KE              
Sbjct: 568  KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ-LEALEKEK------------- 613

Query: 3507 GCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTG 3566
                +LE+++Q+LQ VA++ +   Q +  + Q E A+      +   ++E+   ++    
Sbjct: 614  --AAKLEILQQQLQ-VANEARDSAQTSVTQAQREKAE------LSRKVEELQACVETARQ 664

Query: 3567 QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3621
            +Q E  + V+         E  LR   +      ++ +EK+ L+  +  L+E ++
Sbjct: 665  EQHEAQAQVAE-------LELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLK 712


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  162 bits (409), Expect = 8e-39
 Identities = 259/1287 (20%), Positives = 555/1287 (43%), Gaps = 201/1287 (15%)

Query: 147  EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQ----LQEFEAAIKQ 202
            EQ A    T +  ++S+     ++ E   RE  E +VT  TE L +    +Q+ +  + Q
Sbjct: 162  EQKAAQLATEIADIKSK-----YDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQ 216

Query: 203  RDGI--ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTA 260
            R GI  +  L   L Q +   D      LE   +S+KL+ + ++LQ+      +T S   
Sbjct: 217  RPGIEDVAVLKKELVQVQTLMDNMT---LERERESEKLKDECKKLQSQYASSEATISQLR 273

Query: 261  ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSN 320
            ++L +  Q++  + Q+L++    + +  +K +  T  +  L+++    ++E+    E+ +
Sbjct: 274  SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL--LKKEQDYTKLEEKHNEESVS 331

Query: 321  KEEIQ----EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376
            K+ IQ    +K+   ++L +++   E     +  +L+   +   +L+E++ +   + +++
Sbjct: 332  KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391

Query: 377  KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE 436
            K E    +Q+  +  +   QL   + +L  +  +  +   +   R++++ Q   E+L  +
Sbjct: 392  KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451

Query: 437  LDEMYGQQIV------QMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL 490
              ++   Q+       Q+K+++      Q +  KT+ + + + AL+  +   + E Q  L
Sbjct: 452  EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL 511

Query: 491  MNVA--INELNIKLQDTNSQKEKLKEELGLILEEK------------------------C 524
              V   I + + K+Q+  +  +K KE + L+ +E+                         
Sbjct: 512  EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNH 571

Query: 525  ALQRQLEDLVEELSFSREQIQRARQTIAEQ------------------ESKLNEAHKSLS 566
             LQ Q+  L E+L    E  ++A++ + +Q                  E+ +NE +  L+
Sbjct: 572  TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN 631

Query: 567  TVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM-LEKEKNAVLDRMAESQEAELERL 625
              ++  +++    +++ EL L  EA  T  +  L+  L+  +NA+ D+     + EL ++
Sbjct: 632  ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK-----QQELNKI 686

Query: 626  RTQL------LFSHEEELSKLKEDLEI--EHRINIEKLKDNL-GIHYKQQIDGLQNEMSQ 676
             TQL      L   +E  S+L+  L+   E  +++E+  + L G   K + D L+ + S+
Sbjct: 687  TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 746

Query: 677  KIETMQFEKDNLITKQNQL-ILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEE 735
            +      ++   +    +L   E+SK  ++++ +V+S   ++  +   L+   + L ++E
Sbjct: 747  EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE 806

Query: 736  KEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHT 795
            +EK  L+Q+ + L  +T++  +++  +      +  +++ E   L  E  T++D L   +
Sbjct: 807  EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL---S 863

Query: 796  PVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEK 855
             VS        DS+K+    S +EKE +       DL++ C +L  +++ Q         
Sbjct: 864  KVS--------DSLKNSK--SEFEKENQKGKAAILDLEKTCKELKHQLQVQ--------- 904

Query: 856  NFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSS 915
              E   +E +E       +K  LE  K     + K +L ++ E+L +Q  N  T+K    
Sbjct: 905  -MENTLKEQKE-------LKKSLEKEKEASH-QLKLELNSMQEQL-IQAQN--TLKQNEK 952

Query: 916  VFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISF 975
               + +  + E  +  E  +K    L  +L++   +K EL  +   L +QL Q   E++ 
Sbjct: 953  EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK---LQQQLTQAAQELAA 1009

Query: 976  LNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSV 1035
              E++  L+   E+     ++L+       +E + +        L  V    S   E  +
Sbjct: 1010 EKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD-----LKSVEEKLSLAQEDLI 1064

Query: 1036 SKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL--ILDHLPSVTKESSLRATQPSEND 1093
            S  N+  G ++K++ E K +   +      K++QL      L  + KE SL+        
Sbjct: 1065 SNRNQ-IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK-------- 1115

Query: 1094 KLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFA 1153
              +KEL   KS+  ++                       E ++  ++K +  L EEL   
Sbjct: 1116 --EKELVNEKSKLAEI-----------------------EEIKCRQEKEITKLNEELKSH 1150

Query: 1154 QEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEY 1213
            + E IKE+  +   + Q +  Q+   +GK        L+ AV +E             + 
Sbjct: 1151 KLESIKEITNLKDAK-QLLIQQKLELQGK-----ADSLKAAVEQE-------------KR 1191

Query: 1214 YTPALKCEVNAEDKENSGDYISENE--DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL 1271
                LK +V  E++E   ++I +      E+++    ++  +EN   L  ++T     L 
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL- 1250

Query: 1272 VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDL 1331
                 + K W         +  +  + + E +   +  ++  LE    N++ +  +L  L
Sbjct: 1251 ---GTVKKEW---------QSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL--L 1296

Query: 1332 EK-TKLEEQVQELESLISSLQQQLKET 1357
            E+  K E ++++L++ +  LQ++L  T
Sbjct: 1297 ERCLKGEGEIEKLQTKVLELQRKLDNT 1323



 Score =  158 bits (399), Expect = 1e-37
 Identities = 249/1160 (21%), Positives = 479/1160 (41%), Gaps = 170/1160 (14%)

Query: 1856 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915
            K  EA+ +  +   H   +   L R+     ++  + L+        L EE    E+L  
Sbjct: 58   KHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQAS------LKEEKWYSEELKK 111

Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
            EL K +G+           ++Q  +   ++     EL     +L+E + E   I++ ++L
Sbjct: 112  ELEKYQGL-----------QQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDL 160

Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
              ++   +  E   ++ +   + E+ ++E  E +    ++ ++L K+   +         
Sbjct: 161  FEQKAAQLATEIADIKSKY--DEERSLREAAEQK--VTRLTEELNKEATVI--------- 207

Query: 2036 RFIELEQEKNTELMDLR--QQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ 2093
                  Q+  TEL+     +    L+K+L +++  +D   ++RE E +  + E +KL+ Q
Sbjct: 208  ------QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261

Query: 2094 --------------LKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDI 2139
                          L   P+   +   + ++++   N L +K    +E LL KEQ    +
Sbjct: 262  YASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKL 321

Query: 2140 QERNEE-----------IEKLEFRVRELEQALLVSADTFQKVE---DRKHFGAVEAKPEL 2185
            +E++ E           + + +   ++L+  L  S  +  ++      K     + K EL
Sbjct: 322  EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL 381

Query: 2186 S--------LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
            S        L+ + +  +   + KE+    L+ ++ Q   +L     ++ + H +L+ Q+
Sbjct: 382  SEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 441

Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV----E 2293
            + S+ +L + EQ+    +  + +L   +KE    ST+ QH L  K  Q  QE++      
Sbjct: 442  QLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL-DKTKQQHQEQQALQQST 500

Query: 2294 IDQLNEQVTKLQQQL--------KITTDNKVIEEKNELIRDLETQIECLMS------DQE 2339
              +L E    L+Q L        KI     ++++  E I  LE + E L +       + 
Sbjct: 501  TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560

Query: 2340 CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2399
             V    +E+   L E + +L ++L N  +       +L ++    K  L       L+LE
Sbjct: 561  AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620

Query: 2400 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLK----RERESVEKIQSIPENSVNVAI 2455
              V   N ++   K  + + + ++   T+ L S +     +R  ++      +N++    
Sbjct: 621  TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680

Query: 2456 DHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTV---SAKD 2512
              L+K   +L+ V T       E+ +  +S  +  K   ++LE +  +LE  +    A  
Sbjct: 681  QELNKITTQLDQV-TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739

Query: 2513 LELTQCYKQ-IKDMQEQGQFETEM------------LQKKIVNLQKIVEEKVAAALVSQI 2559
            LE+    +Q ++D+Q+Q Q  T++            ++K+IV+  ++  +K + AL S  
Sbjct: 740  LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799

Query: 2560 QLEAVQEYAK--FCQDNQTISSEP--ERTNIQNLNQLREDELGS---DISALTLRISELE 2612
            Q    QE  K    QD +T+S E   +   + N  Q    EL     +  AL   +S ++
Sbjct: 800  QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859

Query: 2613 SQVVEMHTSLILEKEQVEIAEKN----VLEKEKKLLELQKLL----------EGNEKKQR 2658
             ++ ++  SL   K + E   +     +L+ EK   EL+  L          +   KK  
Sbjct: 860  DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919

Query: 2659 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELAS--YKEKAEKLQ 2716
            EKEK+ S Q    L +  E     + +   NE E  + +    + + +S   K++ E LQ
Sbjct: 920  EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979

Query: 2717 EELLVKETNMT----SLQKDLSQVRDHLAEAKEKLSIL----EKEDETEVQ--------E 2760
             EL +     T     LQ+ L+Q    LA  KEK+S+L    EK  ET  Q        E
Sbjct: 980  GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039

Query: 2761 SKKACMFEPLPIKLSKSIASQTD---GTLKISSSNQTPQILVKNAGIQINLQSECSSEEV 2817
            S+     + L     K   +Q D      +I + N+  Q L K A   +  Q     E+ 
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL-KTAKATLE-QDSAKKEQQ 1097

Query: 2818 TEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQC 2877
             +   +  + I+K + L   E+++ +S+ ++E E +K      +  L EE          
Sbjct: 1098 LQERCKALQDIQKEKSLKEKELVNEKSK-LAEIEEIKCRQEKEITKLNEE---------- 1146

Query: 2878 LRSKEGSSIPELAH-SDAYQ 2896
            L+S +  SI E+ +  DA Q
Sbjct: 1147 LKSHKLESIKEITNLKDAKQ 1166



 Score =  145 bits (365), Expect = 1e-33
 Identities = 237/1166 (20%), Positives = 492/1166 (42%), Gaps = 155/1166 (13%)

Query: 321  KEEIQEKETIIEELNTKIIEEEKKTLELKDKL-----------TTADKLLGELQEQIVQK 369
            ++E+Q+ +  ++E      EE KK LE    L           T +   L  L++Q+ + 
Sbjct: 89   RQEVQDLQASLKE-EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147

Query: 370  NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
              E  N+K      +QK  Q + EI  +    +E +       Q  T + + + +E    
Sbjct: 148  QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA-TV 206

Query: 430  LEQLRAELDEMYG-QQIVQMKQELIRQHMAQMEEMKTRHKGEME---------------- 472
            ++ L+ EL +  G + +  +K+EL+ Q    M+ M    + E E                
Sbjct: 207  IQDLKTELLQRPGIEDVAVLKKELV-QVQTLMDNMTLERERESEKLKDECKKLQSQYASS 265

Query: 473  ----NALRSY-----SNITVNEDQIKLMNVAINELN-----------------IKLQDTN 506
                + LRS        + V   +++ +  ++NEL                   KL++ +
Sbjct: 266  EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325

Query: 507  SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLS 566
            +++   K+ +   L +K       + L   LS S   + R    ++E+     +  + LS
Sbjct: 326  NEESVSKKNIQATLHQK---DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382

Query: 567  TVE----DLKAEIVSASESRKELE---LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619
             VE     LKAE     + R+E E   L+ ++E+     KL   E++      R+ E ++
Sbjct: 383  EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442

Query: 620  AELERL--RTQLLFSHEEELSKLKEDL--------EIEHRINIEKLKDNLGIHYKQQIDG 669
               E+L  + Q +   + +LS+L+E L        E++H+++  K +     H +QQ   
Sbjct: 443  LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ-----HQEQQ--A 495

Query: 670  LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ------SLVNSKSEEMTLQINE 723
            LQ   + K+   Q + + ++ +      +I  L+ L Q      SL+  + E++  +I  
Sbjct: 496  LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555

Query: 724  LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
             + E  +L Q +++  TL+++V +L  K +   +  K+ + +L ++  + +A     +D 
Sbjct: 556  GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615

Query: 784  KKTLEDML-KIHTPVSQEERLIFLDSIKSKSKDSV------------------WEKEIEI 824
              +LE  + ++++ +++ +  +    I+ K+K  +                   +     
Sbjct: 616  VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675

Query: 825  LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884
            L ++ ++L +   QL++   K ++      +  E + +E +E+Y  L +  ++LE    K
Sbjct: 676  LQDKQQELNKITTQLDQVTAKLQDKQEHCSQ-LESHLKEYKEKYLSLEQKTEELEGQIKK 734

Query: 885  QE---LEYKSKLKALNEELHLQRINPTTVKMK----SSVFDEDKTFVAETLEMGEVVEKD 937
             E   LE K+  +   ++L  QR   T ++++    S   + +K  V+ T    +   + 
Sbjct: 735  LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794

Query: 938  TTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE----ISFLNEEVKSLKQEKE----- 988
               + +KL   + EK  L Q    LS++ K +H E    I     E++ +K EKE     
Sbjct: 795  LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE 854

Query: 989  --QVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVN--KSFGE 1044
               V  +  ++   + ++++E  +      +++LD   T      +  V   N  K   E
Sbjct: 855  LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE 914

Query: 1045 ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104
              K + ++K +   + +   S QEQLI         +++L+  +  E  +LQ  +N LK 
Sbjct: 915  LKKSLEKEKEASHQLKLELNSMQEQLI-------QAQNTLKQNE-KEEQQLQGNINELKQ 966

Query: 1105 EQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI 1164
                 + Q+EA +  L +      +     +EN+  + L    +EL  A++EKI  LQ  
Sbjct: 967  SSEQKKKQIEALQGELKIAVLQKTE-----LENKLQQQLTQAAQELA-AEKEKISVLQNN 1020

Query: 1165 HQLELQTMKTQETGDEGKPLHLLIGKLQ-KAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
            ++   +T K  ++   G+   LL  +   K+V E+ S   + L S   +      K    
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN-KLIQE 1079

Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
             +  + + +  S  ++ +LQ+    +QD Q+       ++  E +KL  ++    +   Q
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR---Q 1136

Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQ---V 1340
            + +  KL    E L   + E +   + + + + + +  K +L    D  K  +E++    
Sbjct: 1137 EKEITKL---NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQ 1193

Query: 1341 QELESLISSLQQQLKETEQNYEAEIH 1366
            Q L+  +   +++LK+     EA++H
Sbjct: 1194 QILKDQVKKEEEELKKEFIEKEAKLH 1219



 Score =  141 bits (355), Expect = 1e-32
 Identities = 289/1385 (20%), Positives = 573/1385 (41%), Gaps = 232/1385 (16%)

Query: 1135 MENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKA 1194
            +  E      SLKEE  +++E K KEL+K   L+ Q         E KP  L+       
Sbjct: 88   LRQEVQDLQASLKEEKWYSEELK-KELEKYQGLQQQ---------EAKPDGLVT------ 131

Query: 1195 VSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQE 1254
               + S  LQ+L   L E  T     +   +  E     ++  E  +++    E +  +E
Sbjct: 132  ---DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLA-TEIADIKSKYDEERSLRE 187

Query: 1255 NMHTLLNKVTEEYNK-LLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313
                 + ++TEE NK   V+Q   +++  +         G E++   + E + + + M N
Sbjct: 188  AAEQKVTRLTEELNKEATVIQDLKTELLQRP--------GIEDVAVLKKELVQVQTLMDN 239

Query: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQ 1373
            +    +  + +   L+D E  KL+ Q    E+ IS L+ +L +  Q     +  LQK   
Sbjct: 240  MT---LERERESEKLKD-ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS 295

Query: 1374 AVSESTVPPSLPVDSVVITESD---AQRTMYPGSCVKKNIDGTI--------EFSGEFGV 1422
            +V+E T       ++++  E D    +      S  KKNI  T+        +       
Sbjct: 296  SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355

Query: 1423 KEETNI----VKLLEK-QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKEN-----TA 1472
             E T++    V+L EK +  ++L+EE+++V        A+  +L +    KE       +
Sbjct: 356  SE-TSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 414

Query: 1473 SSKQAHAVCQQEQHYFNEM--------KLSQDQIGFQTFETVDVKFK-----EEFKP--- 1516
               Q H+   + +    E         +LS +++  +  +  D++ K     E+ K    
Sbjct: 415  EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474

Query: 1517 --------LSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSI--H 1566
                    L K   +H ++  L  S    + E+++ +  +  ++  KD+     +++   
Sbjct: 475  NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534

Query: 1567 DEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE-----HQQATELLRQAHMRQMERQRE 1621
             + ++S ++  R+ +  + Q  +    ++ Q QE      +Q T+L  +    Q E  ++
Sbjct: 535  SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK-NQSESHKQ 593

Query: 1622 DQEQLQEEIKRLNRQL--AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
             QE L ++++     L  AQ   +  E  V+E    L E  E + QL +  + K    L 
Sbjct: 594  AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653

Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVV 1739
              + +T    + Q                        L   + ALQ     L KI  ++ 
Sbjct: 654  AEAAKTAQRADLQNH----------------------LDTAQNALQDKQQELNKITTQLD 691

Query: 1740 KTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE---EHTRVTDESIP 1796
            + TA +++           +   SQ  + L    E   S++    E   +  ++  +S+ 
Sbjct: 692  QVTAKLQDK----------QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741

Query: 1797 SYSGSDMPRNDINMWSKVTEE----GTELSQRLV--RSGFAGTEIDPENE-ELMLNISSR 1849
              +  +    D+    ++  +     TELS++L   +   + T +D + + E + +I  +
Sbjct: 742  VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801

Query: 1850 L--QAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES 1907
            L  Q   +++L+   ET SQ       +T++  E    + + T +     EL++   E+ 
Sbjct: 802  LTKQEEEKQILKQDFETLSQ-------ETKIQHEELNNRIQTTVT-----ELQKVKMEKE 849

Query: 1908 RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ-ELEAEQ 1966
                +L+    K   V D   + K+ FE++ Q+    I  LE+      ++LQ ++E   
Sbjct: 850  ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909

Query: 1967 QQIQEERELLSRQKEA---MKAEAGPVEQQLLQETEKLMK-EKLEVQCQA-----EKVRD 2017
            ++ +E ++ L ++KEA   +K E   +++QL+Q    L + EK E Q Q      ++  +
Sbjct: 910  KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969

Query: 2018 DLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA-------LEKQLEKMR---K 2067
              +KQ++AL+ +++  V +  ELE +   +L    Q+  A       L+   EK +   K
Sbjct: 970  QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFK 1029

Query: 2068 FLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
             L      RE E    +Q+++ +E++L +             ++    N +  +     E
Sbjct: 1030 QLQSDFYGRESELLATRQDLKSVEEKLSLAQE----------DLISNRNQIGNQNKLIQE 1079

Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSL 2187
            L  +K  L++D  ++ +++++   R + L+          QK +  K    V  K +L+ 
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQE---RCKALQD--------IQKEKSLKEKELVNEKSKLAE 1128

Query: 2188 EVQLQAERDAIDRKEKEITNLEEQLEQFR----EELENKNEEVQQLHMQ-LEIQKKESTT 2242
              +++       R+EKEIT L E+L+  +    +E+ N  +  Q L  Q LE+Q K  + 
Sbjct: 1129 IEEIKC------RQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182

Query: 2243 R--LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2300
            +  +++ ++  ++ KD ++K    +K+         H         I+EKEV + +  E 
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH-------SEIKEKEVGMKKHEEN 1235

Query: 2301 VTKLQQQLKITTDN-----KVIEEKNELIRDLETQIECLMSD----QECVKRNREE---- 2347
              KL  Q+    +N     K  +     + +LE Q + L  +    +  V+ N++E    
Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295

Query: 2348 ---------EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
                     EIE+L   + +LQ++L N    T+     L  E  SL+ +    +  K A 
Sbjct: 1296 LERCLKGEGEIEKLQTKVLELQRKLDN----TTAAVQELGRENQSLQIKHTQALNRKWAE 1351

Query: 2399 EQQVE 2403
            + +V+
Sbjct: 1352 DNEVQ 1356



 Score =  139 bits (351), Expect = 4e-32
 Identities = 277/1403 (19%), Positives = 610/1403 (43%), Gaps = 217/1403 (15%)

Query: 479  SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEEL--------------GLILEEKC 524
            SN+ +  D + L+   + +L   L++     E+LK+EL              GL+ +   
Sbjct: 76   SNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSA 135

Query: 525  ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE---S 581
             LQ  LE  +EE       I++ +    ++ ++L      + +  D +  +  A+E   +
Sbjct: 136  ELQ-SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194

Query: 582  RKELELKHEAEVTNYKIKLEMLEK---EKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638
            R   EL  EA V    +K E+L++   E  AVL    + +  +++ L   +    E E  
Sbjct: 195  RLTEELNKEATVIQ-DLKTELLQRPGIEDVAVL----KKELVQVQTLMDNMTLERERESE 249

Query: 639  KLKEDLE------IEHRINIEKLKDNLG---------IHYKQQIDGLQNEMSQKIETMQF 683
            KLK++ +            I +L+  L          +   Q++    NE++QK +T+  
Sbjct: 250  KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL-- 307

Query: 684  EKDNLITKQNQLILEISKLKDL-QQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 742
              +NL+ K+     + +KL++   +  V+ K+ + TL   +L  + ++  +    + +L 
Sbjct: 308  -TENLLKKEQ----DYTKLEEKHNEESVSKKNIQATLHQKDLDCQ-QLQSRLSASETSLH 361

Query: 743  QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE--------DMLKIH 794
            +   EL  K E  +K +KE+ ++++ K+  L+AE   L+ +++  E        ++ ++H
Sbjct: 362  RIHVELSEKGEATQK-LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420

Query: 795  TPVSQEERLI-----FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 849
            + + + ER +      L   +  S + + +KE ++      DL+ +  +L E+++++   
Sbjct: 421  SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQV-----ADLQLKLSRLEEQLKEKVTN 475

Query: 850  FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTT 909
             +  +   +   Q+ QE+ A        L +++N  E   +   +  +++  +Q +    
Sbjct: 476  STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR---QIGDKDQKIQNLEALL 532

Query: 910  VKMKS--SVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLK 967
             K K   S+ ++++  +   ++ GE       +L EK    + +  +L+++L + SE  K
Sbjct: 533  QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592

Query: 968  QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027
            Q       L+++V     ++++  LR  +          + V S +T V+ L        
Sbjct: 593  QAQEN---LHDQV-----QEQKAHLRAAQ----------DRVLSLETSVNEL-------- 626

Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT 1087
                    S++N+S  + S++ ++ K   E +   E +K  Q           ++ L   
Sbjct: 627  -------NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ-------RADLQNHLDTA 672

Query: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147
            Q +  DK Q+ELN + ++ + +  +++ ++         H  Q+  +++  K+K L    
Sbjct: 673  QNALQDK-QQELNKITTQLDQVTAKLQDKQ--------EHCSQLESHLKEYKEKYLS--L 721

Query: 1148 EELIFAQEEKIKELQKIHQLELQTMKTQETGD------EGKPLHLLIGKLQKAVSEECSY 1201
            E+     E +IK+L+    LE++  K Q   D          L L   +L K +  E   
Sbjct: 722  EQKTEELEGQIKKLE-ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780

Query: 1202 FLQTLCSVLGEYYT-PALKCEVNAEDKEN---SGDYISENEDPELQDYRYEVQDFQENMH 1257
               T   +  +     ++K ++  +++E      D+ + +++ ++Q    E+ +  +   
Sbjct: 781  VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ--HEELNNRIQTTV 838

Query: 1258 TLLNKVTEEYNKLL----VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313
            T L KV  E   L+     ++ +LSK+        K EF +EN  K +   L +      
Sbjct: 839  TELQKVKMEKEALMTELSTVKDKLSKV-SDSLKNSKSEFEKEN-QKGKAAILDLEKTCKE 896

Query: 1314 LE-DIDVNHKSKLSSLQDLEKT--KLEEQVQELESLISSLQQQL---KETEQNYEAEIHC 1367
            L+  + V  ++ L   ++L+K+  K +E   +L+  ++S+Q+QL   + T +  E E   
Sbjct: 897  LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956

Query: 1368 LQKRLQAVSESTVPPSLPVDSV--VITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425
            LQ  +  + +S+      ++++   +  +  Q+T       ++      E + E   KE+
Sbjct: 957  LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE---KEK 1013

Query: 1426 TNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQ 1485
             ++++   ++ QE  ++  +      S   A + +L  +    E   S  Q   +  + Q
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV----EEKLSLAQEDLISNRNQ 1069

Query: 1486 HYFNEMKLSQD-QIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDC 1544
               N+ KL Q+ +    T E    K +++ +   K L +  KE  L      ++   K  
Sbjct: 1070 -IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEK---ELVNEKSK 1125

Query: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQA 1604
            +  I E    ++K       +++E+    +++ +++      L+D +Q L++Q  E Q  
Sbjct: 1126 LAEIEEIKCRQEKEI---TKLNEELKSHKLESIKEI----TNLKDAKQLLIQQKLELQGK 1178

Query: 1605 TELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALK 1664
             + L+ A    +E+++ +Q+ L++++K+   +L +           E+E  L  E++  K
Sbjct: 1179 ADSLKAA----VEQEKRNQQILKDQVKKEEEELKKE--------FIEKEAKLHSEIKE-K 1225

Query: 1665 QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ----TFKEKELDRKPEDVPPEIL--- 1717
            ++ +   E+   +L    T     NEN G V+++      +  EL+++ +D+  EI    
Sbjct: 1226 EVGMKKHEENEAKLTMQITAL---NENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282

Query: 1718 ------SNERYAL-----------QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
                   +ER AL           +K   ++L++  ++  TTAAV+E      LG  ++S
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQE------LGRENQS 1336

Query: 1761 SKSQSSASLIWRSEAEASVKSCV 1783
             + + + +L  +   +  V++C+
Sbjct: 1337 LQIKHTQALNRKWAEDNEVQNCM 1359



 Score =  139 bits (350), Expect = 6e-32
 Identities = 258/1338 (19%), Positives = 559/1338 (41%), Gaps = 183/1338 (13%)

Query: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2268
            E  L   R+++    +EVQ L   L+ +K  S    +ELE+   L + + +  GL    S
Sbjct: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134

Query: 2269 DAMSTQDQHV---------------LFGKFAQIIQEKEVEIDQLNEQVTKLQQ--QLKIT 2311
              + + +Q +               LF + A  +  +  +I    ++   L++  + K+T
Sbjct: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194

Query: 2312 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2371
               + + ++  +I+DL+T         E ++R   E++  L + + ++Q  + N+  +  
Sbjct: 195  RLTEELNKEATVIQDLKT---------ELLQRPGIEDVAVLKKELVQVQTLMDNMTLERE 245

Query: 2372 MNAHSLSEEADSLKHQ-------LDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424
              +  L +E   L+ Q       +  + +E     Q+V    +E+  +K+ + E   K  
Sbjct: 246  RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQ 305

Query: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484
             LT+ L  LK+E++  +  +   E SV+      +  + +L+    +  L + E   +  
Sbjct: 306  TLTENL--LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI 363

Query: 2485 SFEENGKGSII-NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQG---QFETEMLQKKI 2540
              E + KG     L+  L ++E+       E  Q  +Q ++ ++ G   Q E   L  K+
Sbjct: 364  HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423

Query: 2541 VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSD 2600
            +  ++ + E     L  Q QL +           + +  E +  ++Q      E++L   
Sbjct: 424  LETERQLGE-AHGRLKEQRQLSS----------EKLMDKEQQVADLQLKLSRLEEQLKEK 472

Query: 2601 ISALTLRISEL--------ESQVVEMHTSLILEKEQVEIAE--KNVLEKEKKLLELQKLL 2650
            ++  T    +L        E Q ++  T+  L + Q ++ +  + + +K++K+  L+ LL
Sbjct: 473  VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532

Query: 2651 EGNEKKQREKEKKR---------SPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2701
            + +++     EK+R            +  VL    E  H+ +E       E L+ +S + 
Sbjct: 533  QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ-VTQLTEKLKNQSESH 591

Query: 2702 KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2761
            K    +  ++ ++ +  L   +  + SL+  ++++   L E+KEK+S L+ + + + +  
Sbjct: 592  KQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE-- 649

Query: 2762 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEII 2821
                        L  + A++T     + +   T Q  +++   ++N        ++T  +
Sbjct: 650  -----------LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN--------KITTQL 690

Query: 2822 SQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR-- 2879
             Q T K++  QE            H S+ E+  +E+      L+++   L+  I+ L   
Sbjct: 691  DQVTAKLQDKQE------------HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738

Query: 2880 SKEGSSIPELAHSDAYQTR------EICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2933
            S E  +  E A  D  Q R      E+ +++          +  S   D+  +    ES 
Sbjct: 739  SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798

Query: 2934 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISS 2993
                +  ++ K +L+       Q   +     ++    ++ ++ +  + E++A +  +S+
Sbjct: 799  KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM-EKEALMTELST 857

Query: 2994 LKDLITKMQLQREAEVYDSSQSHESFSDWRGE-LLLALQQVFLEERSVLLAAFRTELTAL 3052
            +KD ++K+     ++   +S+S     + +G+  +L L++   E +  L    + E T  
Sbjct: 858  VKDKLSKV-----SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL--QVQMENTLK 910

Query: 3053 GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQ 3112
               +    L   ++   +  +E  +  E L +A  ++ L + +    Q+ G    LK+  
Sbjct: 911  EQKELKKSLEKEKEASHQLKLELNSMQEQLIQA--QNTLKQNEKEEQQLQGNINELKQSS 968

Query: 3113 ESEKPSQELLEYNIQ-----------QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV 3161
            E +K   E L+  ++           + Q Q+ +   EL++ K++ + LQ      +   
Sbjct: 969  EQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETF 1028

Query: 3162 AEL-------KSELAQTKLELETT-----------------LKAQHKHLKELEAFRLEVK 3197
             +L       +SEL  T+ +L++                  +  Q+K ++EL+  +  ++
Sbjct: 1029 KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088

Query: 3198 D----KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE---RDKEELEDLKFSLE 3250
                 K  ++      L   QK+    +  L  EK+KL   EE   R ++E+  L   L+
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK 1148

Query: 3251 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIR 3310
            S K  +++    L+  KQLL   QQK+E Q      + + EQ +  + Q+L +  K    
Sbjct: 1149 SHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAAVEQEKRNQ-QILKDQVKKEEE 1205

Query: 3311 EMSST-LDRERELHAQLQSSDGTGQSRPPLPSEDL----------LKELQKQLEEKHSRI 3359
            E+    +++E +LH++++  +  G  +       L          L  ++K+ +    R+
Sbjct: 1206 ELKKEFIEKEAKLHSEIKEKE-VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264

Query: 3360 VELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQL 3419
             EL  +T+  + +       ++ ++   R  L    E   +G+ ++ +LQ+KV +LQR+L
Sbjct: 1265 SELEKQTDDLRGEIAVLEATVQNNQDERRALL----ERCLKGEGEIEKLQTKVLELQRKL 1320

Query: 3420 EEKRQQVYKLDLEGQRLQ 3437
            +     V +L  E Q LQ
Sbjct: 1321 DNTTAAVQELGRENQSLQ 1338



 Score =  116 bits (290), Expect = 5e-25
 Identities = 269/1358 (19%), Positives = 571/1358 (42%), Gaps = 197/1358 (14%)

Query: 864  LQEEYACLLKVKDDLEDSKNKQELEYK---------SKLKALNEELHLQRINPTTVKMKS 914
            L+EE     ++K +LE  +  Q+ E K         ++L++L ++L   +     +K   
Sbjct: 99   LKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMK 158

Query: 915  SVFDEDKTFVA-----------ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963
             +F++    +A           E   + E  E+  T L E+L        + +  + DL 
Sbjct: 159  DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELN-------KEATVIQDLK 211

Query: 964  EQLKQKHG--EISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
             +L Q+ G  +++ L +E+  ++   + ++L  RE E     +  + +QS   Q +S   
Sbjct: 212  TELLQRPGIEDVAVLKKELVQVQTLMDNMTLE-RERESEKLKDECKKLQS---QYASSEA 267

Query: 1022 GVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKE 1081
             +  + S  A+G          +E  + V++    ++ +V E +++ Q + ++L  + KE
Sbjct: 268  TISQLRSELAKGP---------QEVAVYVQELQKLKS-SVNELTQKNQTLTENL--LKKE 315

Query: 1082 SSLRATQPSENDKLQKELNVLKS-EQNDLRLQMEAQRICLS--LVYSTHVDQVREYMENE 1138
                  +   N++   + N+  +  Q DL  Q    R+  S   ++  HV+       +E
Sbjct: 316  QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL------SE 369

Query: 1139 KDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE 1198
            K +A   LKEEL   +        K   L+ +  + Q+  +E K  H L  +LQ  +++ 
Sbjct: 370  KGEATQKLKEELSEVET-------KYQHLKAEFKQLQQQREE-KEQHGL--QLQSEINQL 419

Query: 1199 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258
             S  L+T    LGE +   LK     E ++ S +        +L D   +V D Q  +  
Sbjct: 420  HSKLLETERQ-LGEAHG-RLK-----EQRQLSSE--------KLMDKEQQVADLQLKLSR 464

Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQ--------QTDGMKLEFGEENLPKEETEFLSIHSQ 1310
            L  ++ E+      LQ +L K   Q        Q+   KL   + +L +   +      +
Sbjct: 465  LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524

Query: 1311 MTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQK 1370
            + NLE +    K  +S L+  E+  L  ++Q  E   + L Q L+E     + ++  L +
Sbjct: 525  IQNLEALLQKSKENISLLEK-EREDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQVTQLTE 582

Query: 1371 RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG-VKEETNIV 1429
            +L+  SES       +   V  +    R            D  +        +  + N  
Sbjct: 583  KLKNQSESHKQAQENLHDQVQEQKAHLRAAQ---------DRVLSLETSVNELNSQLNES 633

Query: 1430 KLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFN 1489
            K    Q   Q++ +   ++ + +   AQ+ +L       +N    KQ        Q    
Sbjct: 634  KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693

Query: 1490 EMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTIS 1549
              KL   Q      E+   ++KE++  L ++  E   +I    +D  ++  SK+  L   
Sbjct: 694  TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753

Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609
            ++          ++ ++ ++ + + + S+QL + +E +   R +L    Q+  +A E ++
Sbjct: 754  QQ----------QRQLNTDLELRATELSKQLEMEKEIVSSTRLDL----QKKSEALESIK 799

Query: 1610 QAHMRQMERQ---REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666
            Q   +Q E +   ++D E L +E K  + +L  R     +  V+E ++V +E+   + +L
Sbjct: 800  QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI----QTTVTELQKVKMEKEALMTEL 855

Query: 1667 SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK 1726
            S   ++KL     +  + +   ++++ E E Q  K   LD                 L+K
Sbjct: 856  STV-KDKL-----SKVSDSLKNSKSEFEKENQKGKAAILD-----------------LEK 892

Query: 1727 ANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE 1786
                L   L   ++ T   ++         L +S + +  AS   + E  +  +  +  +
Sbjct: 893  TCKELKHQLQVQMENTLKEQKE--------LKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944

Query: 1787 HTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQ-RLVRSGFAGTEIDPENEELMLN 1845
            +T   +E        ++  N++   S+  ++  E  Q  L  +    TE++ + ++ +  
Sbjct: 945  NTLKQNEKEEQQLQGNI--NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002

Query: 1846 ISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE---ATESLKCQEELRER 1902
             +  L A  EK    IS   +  E ++ T  +L  + + ++ E     + LK  EE    
Sbjct: 1003 AAQELAAEKEK----ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1058

Query: 1903 LHEESRA-------REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRL------- 1948
              E+  +       + +L  EL  A+  ++  + +K   E+Q+QE+   +  +       
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK---EQQLQERCKALQDIQKEKSLK 1115

Query: 1949 EQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV 2008
            E+EL+   ++L E+E  + + ++E   L+ + ++ K E+      L    + L+++KLE+
Sbjct: 1116 EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175

Query: 2009 QCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKF 2068
            Q +A+ ++  ++++ +  +I +++QV +    E+E+         + + +EK+ +   + 
Sbjct: 1176 QGKADSLKAAVEQEKRNQQI-LKDQVKK----EEEE--------LKKEFIEKEAKLHSEI 1222

Query: 2069 LDEQAIDREHERD--VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126
             +++   ++HE +      +I  L + L  V +    S+ +  E+E+  + L+ +     
Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282

Query: 2127 ELLLSKEQLQRDIQER----NEEIEKLEFRVRELEQAL 2160
              + + +  +R + ER      EIEKL+ +V EL++ L
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320



 Score =  108 bits (270), Expect = 1e-22
 Identities = 244/1245 (19%), Positives = 512/1245 (41%), Gaps = 184/1245 (14%)

Query: 2505 ESTVSAKDLELTQCYKQIKDMQ---EQGQFETEMLQKKIVNLQKIVEEKVAA-ALVSQIQ 2560
            ES ++ K  ++T   ++++D+Q   ++ ++ +E L+K++   Q + +++     LV+   
Sbjct: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134

Query: 2561 LEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED---ELGSDISALTLRISE------- 2610
             E +Q   +  ++ QT     E  NI+ +  L E    +L ++I+ +  +  E       
Sbjct: 135  AE-LQSLEQQLEEAQT-----ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188

Query: 2611 LESQVVEMHTSLILEKEQVEIAEKNVLEK---------EKKLLELQKLLEGNEKKQREKE 2661
             E +V  +   L  E   ++  +  +L++         +K+L+++Q L++ N   +RE+E
Sbjct: 189  AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMD-NMTLERERE 247

Query: 2662 KKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL- 2720
             ++   + + L++    + S+E +     +  LR+E      E+A Y ++ +KL+  +  
Sbjct: 248  SEKLKDECKKLQSQ---YASSEAT-----ISQLRSELAKGPQEVAVYVQELQKLKSSVNE 299

Query: 2721 VKETNMTSLQKDLSQVRDH--LAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSI 2778
            + + N T  +  L + +D+  L E   + S+ +K  +  + +    C  + L  +LS S 
Sbjct: 300  LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC--QQLQSRLSASE 357

Query: 2779 ASQTDGTLKISSSNQTPQIL-------------VKNAGIQINLQSECSSE-------EVT 2818
             S     +++S   +  Q L             +K    Q+  Q E   +       E+ 
Sbjct: 358  TSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN 417

Query: 2819 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2878
            ++ S+  E   ++ E H       E R +S  + + +E  VA   LK     L  + + L
Sbjct: 418  QLHSKLLETERQLGEAHGRL---KEQRQLSSEKLMDKEQQVADLQLK-----LSRLEEQL 469

Query: 2879 RSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF---DIASEGRGEESESA 2935
            + K  +S  EL H    +T++               L  +Q      +   G  ++    
Sbjct: 470  KEKVTNST-ELQHQ-LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527

Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEP--WLEERKAYINTISS 2993
             ++  +K K  +  +  E   + +  ++   +GE   + Q+ E    L+E+         
Sbjct: 528  LEALLQKSKENISLLEKEREDLYAKIQA--GEGETAVLNQLQEKNHTLQEQ--------- 576

Query: 2994 LKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALG 3053
            +  L  K++ Q E+        H+   + +  L  A  +V   E SV       EL +  
Sbjct: 577  VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV------NELNSQ- 629

Query: 3054 TTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQE 3113
                   LN  ++++ +  ++ +A  E L  A+           +     +     ++QE
Sbjct: 630  -------LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682

Query: 3114 SEKPSQEL--LEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3171
              K + +L  +   +Q KQ    +++  L   K++   L+++    +  + +L+++  + 
Sbjct: 683  LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742

Query: 3172 KLELETTLK--AQHKHLK---ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK 3226
            K   E  L+   Q + L    EL A  L  K    E  +++ T    QKKS     ALE 
Sbjct: 743  KASKEQALQDLQQQRQLNTDLELRATELS-KQLEMEKEIVSSTRLDLQKKSE----ALES 797

Query: 3227 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3286
             K KL + E    EE + LK   E+  Q   +  +  E+    +  +  +++  +M  +A
Sbjct: 798  IKQKLTKQE----EEKQILKQDFETLSQ---ETKIQHEELNNRIQTTVTELQKVKMEKEA 850

Query: 3287 QLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK 3346
             ++E           L + K ++ ++S +L   +   ++ +  +  G++   L  E   K
Sbjct: 851  LMTE-----------LSTVKDKLSKVSDSLKNSK---SEFEKENQKGKA-AILDLEKTCK 895

Query: 3347 ELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMH 3406
            EL+ QL+ +    ++   E +K      +   Q++ +    ++ L   Q    + +K+  
Sbjct: 896  ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955

Query: 3407 ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3466
            +LQ  + +L++  E+K++Q+       + LQG ++    Q+ E E K      L Q L +
Sbjct: 956  QLQGNINELKQSSEQKKKQI-------EALQGELKIAVLQKTELENK------LQQQLTQ 1002

Query: 3467 PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKL 3526
                 L +++ +  VLQ        E +     ++     G   EL   RQ L+ V  KL
Sbjct: 1003 -AAQELAAEKEKISVLQNNY-----EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056

Query: 3527 QVLPQ-------------KASERLQFETAD-DEDFIWVQENIDEIILQLQKLTGQQG-EE 3571
             +  +             K  + L+   A  ++D    ++ + E    LQ +  ++  +E
Sbjct: 1057 SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE 1116

Query: 3572 PSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3631
              LV+  +    + E   RQ  E+T    +L   K +    +  L++  +   Q      
Sbjct: 1117 KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQ------ 1170

Query: 3632 NSSRFSLNGGA-NIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK 3675
               +  L G A +++A +  EK    R +  L+  +K+ E E+ K
Sbjct: 1171 --QKLELQGKADSLKAAVEQEK----RNQQILKDQVKKEEEELKK 1209



 Score = 96.3 bits (238), Expect = 5e-19
 Identities = 166/762 (21%), Positives = 316/762 (41%), Gaps = 117/762 (15%)

Query: 2975 QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF 3034
            Q  E  LEE +     I  +KDL  +   Q   E+ D    ++                 
Sbjct: 138  QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD----------------- 180

Query: 3035 LEERSVLLAAFR--TELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS 3092
             EERS+  AA +  T LT     +A  + +   + +Q  G+E  A +        +  L 
Sbjct: 181  -EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL--------KKELV 231

Query: 3093 EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQE 3152
            ++Q L   M     TL+RE+ESEK   E      ++ QSQ    +  +S ++    +  +
Sbjct: 232  QVQTLMDNM-----TLERERESEKLKDEC-----KKLQSQYASSEATISQLRSELAKGPQ 281

Query: 3153 QLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN--DTL 3210
            +++     + +LKS + +   + +T  +   K  KE +  +LE K   + V   N   TL
Sbjct: 282  EVAVYVQELQKLKSSVNELTQKNQTLTENLLK--KEQDYTKLEEKHNEESVSKKNIQATL 339

Query: 3211 ASEQKKSRELQWALEKEKAKL----------GRSEERDKEELEDLKFSLESQKQRNLQLN 3260
              +    ++LQ  L   +  L          G + ++ KEEL +++   +  K    QL 
Sbjct: 340  HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399

Query: 3261 LLLEQQKQ---LLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317
               E+++Q    L     ++ S+ +  + QL E  GR L+ Q  L SEK+        +D
Sbjct: 400  QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGR-LKEQRQLSSEKL--------MD 450

Query: 3318 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR 3377
            +E+++ A LQ                 L  L++QL+EK +   EL ++ +K       T+
Sbjct: 451  KEQQV-ADLQLK---------------LSRLEEQLKEKVTNSTELQHQLDK-------TK 487

Query: 3378 QQMEKDRQVHRKTLQTEQEANTEGQKKMHEL---QSKVEDLQRQLEEKRQQVYKLDLEGQ 3434
            QQ ++ + + + T    +EA  + ++ + ++     K+++L+  L++ ++ +  L+ E +
Sbjct: 488  QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547

Query: 3435 RLQGIMQEFQKQELEREEKRESRRILYQNL--------NEPTTWSLTSDRTRNWVLQQKI 3486
             L   +Q  + +     + +E    L + +        N+  +     +   + V +QK 
Sbjct: 548  DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKA 607

Query: 3487 EGETKESNYAKL-IEMNGGGTGCNHELEMIRQ-KLQCVASKLQVLPQKASERLQFETADD 3544
                 +     L   +N   +  N   E + Q  +Q  A    +L  +A++  Q   AD 
Sbjct: 608  HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ--RADL 665

Query: 3545 EDFIWVQEN-IDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLT 3603
            ++ +   +N + +   +L K+T Q  +  + +       S  E  L++  E    + Q T
Sbjct: 666  QNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725

Query: 3604 EEKNDLRNMVMKLEEQIRWYRQTG--AGRDNSSRFSLNGGANIEAIIAS-----EKEVWN 3656
            EE   L   + KLE      + +   A +D   +  LN    + A   S     EKE+ +
Sbjct: 726  EE---LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782

Query: 3657 REKLTLQKSLKRAEAEVYKLKAELRNDSLL----QTLSPDSE 3694
              +L LQK  +  E+   KL  +     +L    +TLS +++
Sbjct: 783  STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK 824



 Score = 80.5 bits (197), Expect = 3e-14
 Identities = 138/640 (21%), Positives = 269/640 (42%), Gaps = 49/640 (7%)

Query: 3071 QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQ 3130
            QG++ Q A       D  + L  ++    +       +K+ ++  +     L   I   +
Sbjct: 117  QGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIK 176

Query: 3131 SQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTK-LELETTLKAQHKHLKEL 3189
            S+  E +    + + + T L E+L+ E  V+ +LK+EL Q   +E    LK +   ++ L
Sbjct: 177  SKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL 236

Query: 3190 -EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3248
             +   LE + +++++      L S+   S      L  E AK  +      +EL+ LK S
Sbjct: 237  MDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296

Query: 3249 LE--SQKQRNLQLNLLLEQQKQLLNESQQKIES-QRMLYDAQLSEEQGRNLELQVLLESE 3305
            +   +QK + L  NLL ++Q     E +   ES  +    A L ++     +LQ  L + 
Sbjct: 297  VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS 356

Query: 3306 KVRIREMSSTLDRERELHAQLQSSDGTGQSR-PPLPSEDLLKELQKQLEEKHSRIVELLN 3364
            +  +  +   L  + E   +L+      +++   L +E   K+LQ+Q EEK    ++L +
Sbjct: 357  ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE--FKQLQQQREEKEQHGLQLQS 414

Query: 3365 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3422
            E  +     L+T +Q+ +     ++  Q   E   + ++++ +LQ K+  L+ QL+EK  
Sbjct: 415  EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474

Query: 3423 -----RQQVYKLDLEGQRLQGIMQE--FQKQELEREEKRESRRILYQNLNEPTTWSLTSD 3475
                 + Q+ K   + Q  Q + Q    + +E + + ++  R+I  ++       +L   
Sbjct: 475  NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534

Query: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKL--QVLPQKA 3533
               N  L +K     +E  YAK I+   G T   ++L+     LQ   ++L  ++  Q  
Sbjct: 535  SKENISLLEK----EREDLYAK-IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSE 589

Query: 3534 SERLQFETADDE------DFIWVQENIDEIILQLQKLTGQQGEEPSLVSP-STSCGSLTE 3586
            S +   E   D+           Q+ +  +   + +L  Q  E    VS       + TE
Sbjct: 590  SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649

Query: 3587 RLL-------RQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3639
             LL        Q A+L  H+        D +  + K+  Q+   + T   +D     S  
Sbjct: 650  LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD--QVTAKLQDKQEHCS-- 705

Query: 3640 GGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3679
                +E+ +   KE +    L+L++  +  E ++ KL+A+
Sbjct: 706  ---QLESHLKEYKEKY----LSLEQKTEELEGQIKKLEAD 738



 Score = 39.3 bits (90), Expect = 0.077
 Identities = 59/314 (18%), Positives = 129/314 (41%), Gaps = 19/314 (6%)

Query: 3408 LQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP 3467
            L+ +V+DLQ  L+E++    +L  E ++ QG+ Q+  K +    +     + L Q L E 
Sbjct: 88   LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147

Query: 3468 TTWSLTSDRTRNWVLQQKIEGETKESNY-AKLIEMNGGGTGCNHELEMIRQKLQCVASKL 3526
             T +    + ++   Q+  +  T+ ++  +K  E          ++  + ++L   A+ +
Sbjct: 148  QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVI 207

Query: 3527 QVLPQKASERLQFETAD--DEDFIWVQENIDEIILQLQKLTGQQGEE-----PSLVSPST 3579
            Q L  +  +R   E      ++ + VQ  +D + L+ ++ + +  +E         S   
Sbjct: 208  QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEA 267

Query: 3580 SCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMK---LEEQIRWYRQTGAGRDNSSRF 3636
            +   L   L +   E+  ++ +L + K+ +  +  K   L E +    Q     +     
Sbjct: 268  TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE 327

Query: 3637 SLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL-RNDSLLQTLSPDSEH 3695
                  NI+A +  +    + +   LQ  L  +E  ++++  EL       Q L  +   
Sbjct: 328  ESVSKKNIQATLHQK----DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSE 383

Query: 3696 VTLKRIYGKYLRAE 3709
            V  K    ++L+AE
Sbjct: 384  VETKY---QHLKAE 394



 Score = 33.5 bits (75), Expect = 4.3
 Identities = 28/133 (21%), Positives = 59/133 (44%), Gaps = 11/133 (8%)

Query: 123  FVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPT-----HLEMMESELAGKQHEIEELNRE 177
            F+ +  K  + ++E+E G+      +            +L  ++ E    Q  + EL ++
Sbjct: 1211 FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270

Query: 178  LEEMR--VTYGTEGLQQLQEFEAAIKQR----DGIITQLTANLQQARREKDETMREFLEL 231
             +++R  +      +Q  Q+   A+ +R    +G I +L   + + +R+ D T     EL
Sbjct: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330

Query: 232  TEQSQKLQIQFQQ 244
              ++Q LQI+  Q
Sbjct: 1331 GRENQSLQIKHTQ 1343


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  159 bits (403), Expect = 4e-38
 Identities = 231/1158 (19%), Positives = 491/1158 (42%), Gaps = 164/1158 (14%)

Query: 158  EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
            E M + LA K+ E+EE+  +LE  RV    E  Q LQ  +           ++ A++Q  
Sbjct: 907  EEMRARLAAKKQELEEILHDLES-RVEEEEERNQILQNEK----------KKMQAHIQDL 955

Query: 218  RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL 277
              + DE      +L  +    + + ++++    L    +S    +    + +I     QL
Sbjct: 956  EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015

Query: 278  EEQDHLLEDYQKKKEDFTMQISFLQEKIKV-----YEMEQDKKVENSN----KEEIQEKE 328
             E++   ++  K +    + IS L+E++K       E+E+ K+  +      +++I E +
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ 1075

Query: 329  TIIEELNTKIIEEEKKTLELKDKLTTAD----------KLLGELQEQIVQKNQEIKNMKL 378
              I+EL  ++ ++E+   EL+  L   D          K++ ELQ QI +  ++ ++ K 
Sbjct: 1076 AQIDELKLQLAKKEE---ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132

Query: 379  ELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELD 438
                +++++R  SEE++ L   +E+           +T   Q   QE + K EQ  AEL 
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELED---------TLDTTAAQ---QELRTKREQEVAELK 1180

Query: 439  EMYGQQIVQMKQELIRQHMAQMEEMKTRH-------KGEMENALRSYSNITVNEDQIKLM 491
            +          +E  + H AQ+++M+ RH         ++E A R  +N+  N+  ++  
Sbjct: 1181 KAL--------EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232

Query: 492  NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551
            N  +      LQ   ++ E  +++L   ++E  A   + + L  EL+    ++Q     +
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292

Query: 552  AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
            +   + L EA K         A + S  +  +EL  +   +  N   ++  LE+EKN++ 
Sbjct: 1293 S---TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349

Query: 612  DRMAESQEA--ELER----LRTQL-------------LFSHEEELSKLKEDLE-IEHRI- 650
            ++  E +EA   LE+    L++QL             + S EE   KL +D E +  R+ 
Sbjct: 1350 EQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409

Query: 651  -------NIEKLKDNLGIHYKQQIDGL------QNEMSQKIETMQFEKDNLITKQNQLIL 697
                    +EK K+ L    +Q++D L      Q +++  +E  Q + D L+ ++  +  
Sbjct: 1410 EKALAYDKLEKTKNRL----QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465

Query: 698  EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757
              ++ +D  ++    K  +       L++ +E   + E++   L  ++++L    + + K
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525

Query: 758  QMKEKEND---LQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK 814
             + E E     L+++  ++  +   L+DE +  ED  K+   V+ +            + 
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATED-AKLRLEVNMQ------------AM 1572

Query: 815  DSVWEKEIEILIEENEDLKQQCIQLNEEIE-------KQRNTFSFAEKNFEVNYQELQEE 867
             + +E++++   E+NE+ K+  I+   E+E       KQR     ++K  E++ ++L+ +
Sbjct: 1573 KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ 1632

Query: 868  YACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAET 927
                 K +D++     KQ  + ++++K    EL   R +      +  +F + K    E+
Sbjct: 1633 IEAANKARDEV----IKQLRKLQAQMKDYQRELEEARAS------RDEIFAQSK----ES 1678

Query: 928  LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK--- 984
             +  + +E +  +L E+L  ++R +    Q   +L++++       S L +E + L+   
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738

Query: 985  -QEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFG 1043
             Q +E++      +E++ +  R   +Q          +      S  A   + + NK   
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNK--- 1795

Query: 1044 EESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLK 1103
                   E K   + +    +SK +  I      + +       +  E     K +   +
Sbjct: 1796 -------ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE 1848

Query: 1104 SEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQK 1163
             +  ++ +Q+E +R         H DQ +E ME + +  +  LK +L  A+EE  +    
Sbjct: 1849 KKLKEIFMQVEDER--------RHADQYKEQME-KANARMKQLKRQLEEAEEEATRANAS 1899

Query: 1164 IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
              +L+ +     E  +EG  L   +  L+  +         +  S   + +      E++
Sbjct: 1900 RRKLQRELDDATE-ANEG--LSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELS 1956

Query: 1224 AEDKENSGDYISENEDPE 1241
             +D E+    ++E + P+
Sbjct: 1957 DDDTESKTSDVNETQPPQ 1974



 Score =  151 bits (381), Expect = 1e-35
 Identities = 262/1208 (21%), Positives = 513/1208 (42%), Gaps = 178/1208 (14%)

Query: 225  MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284
            ++  L++T Q ++LQ + ++L   +  +            + ++    HQQ LEE++ L 
Sbjct: 841  VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEG-------ELEEMERKHQQLLEEKNILA 893

Query: 285  EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
            E  Q + E F              E E+ +    + K+E++E   I+ +L +++ EEE++
Sbjct: 894  EQLQAETELFA-------------EAEEMRARLAAKKQELEE---ILHDLESRVEEEEER 937

Query: 345  TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
               L+++       + +L+EQ+ ++    + ++LE   ++ K ++  EEI  L    E+ 
Sbjct: 938  NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL----EDQ 993

Query: 405  QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMK 464
              +  K+ +        ME        QL  E ++      ++ KQE++   + +  + +
Sbjct: 994  NSKFIKEKKL-------MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKE 1046

Query: 465  TRHKGEMENALRSYSNITVN-EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL----I 519
             + + E+E A R     T + +DQI  +   I+EL ++L     ++E+L+  L       
Sbjct: 1047 EKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA---KKEEELQGALARGDDET 1103

Query: 520  LEEKCALQ--RQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVS 577
            L +  AL+  R+L+  + EL    E  + +R    +Q+  L+E  ++L T  +   + + 
Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELE---DTLD 1160

Query: 578  ASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
             + +++EL  K E EV   K  LE   K   A +  M +     LE L  QL     E+ 
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL-----EQA 1215

Query: 638  SKLKEDLEIEHRINIEKLKDNLGIHYK--QQIDGLQNEMSQKIETMQFEKDNLITKQNQL 695
             + K +LE +++  +E     L    K  QQ+        +K++    E    +++ ++L
Sbjct: 1216 KRFKANLE-KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274

Query: 696  ILEIS-KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL 754
             +E++ K   LQ  L N      TL     +K I+      K+  +LE ++Q+ Q   EL
Sbjct: 1275 RVELAEKASKLQNELDNVS----TLLEEAEKKGIKF----AKDAASLESQLQDTQ---EL 1323

Query: 755  LEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK 814
            L+++ ++K N L  +  QLE E + L+++++  E+  K     + E++++ L S  + +K
Sbjct: 1324 LQEETRQKLN-LSSRIRQLEEEKNSLQEQQEEEEEARK-----NLEKQVLALQSQLADTK 1377

Query: 815  DSVWEK--EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872
              V +    IE L E  + L +    L++ +E++   +                      
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY---------------------- 1415

Query: 873  KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFD----EDKTFVAETL 928
               D LE +KN+ + E    L  L  +L  QR   + ++ K   FD    E+K+  A   
Sbjct: 1416 ---DKLEKTKNRLQQE----LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468

Query: 929  EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKE 988
            E     E+D  E   + + TK   L L++ L +  E  ++   +   L  +++ L   K+
Sbjct: 1469 E-----ERDRAEAEAREKETK--ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521

Query: 989  QVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGV-----------VTMTSRGAEGSV 1035
             V     ELE      RA  + V+   TQ+  L D +           V M +  A+   
Sbjct: 1522 DVGKNVHELE---KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER 1578

Query: 1036 S-KVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILD-----HLPSVTKESSLRATQP 1089
              +      EE K ++  +V      + +E KQ  L +       +     E+ + A   
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638

Query: 1090 SENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEE 1149
            +  D++ K+L  L+++  D + ++E  R     +++            E +K L SL+ E
Sbjct: 1639 A-RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA---------QSKESEKKLKSLEAE 1688

Query: 1150 LIFAQEE--KIKELQKIHQLELQTMKTQETG---------DEGKPLHLLIGKLQKAVSEE 1198
            ++  QEE    +  ++  + E   +  + T          DE + L   I +L++ + EE
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748

Query: 1199 CS-------YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQD 1251
             S        F +T   V  +     L  E +A  K ++     E ++ EL+    E++ 
Sbjct: 1749 QSNMELLNDRFRKTTLQV--DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEG 1806

Query: 1252 FQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQM 1311
              ++         E   K+  L+ +L +   ++    KL    E   KE   F+ +  + 
Sbjct: 1807 AVKSKFKATISALEA--KIGQLEEQLEQEAKERAAANKLVRRTEKKLKE--IFMQVEDER 1862

Query: 1312 TNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISS---LQQQL---KETEQNYEAEI 1365
             + +      +   + ++ L K +LEE  +E     +S   LQ++L    E  +    E+
Sbjct: 1863 RHADQYKEQMEKANARMKQL-KRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREV 1921

Query: 1366 HCLQKRLQ 1373
              L+ RL+
Sbjct: 1922 STLKNRLR 1929



 Score =  149 bits (377), Expect = 4e-35
 Identities = 229/1134 (20%), Positives = 478/1134 (42%), Gaps = 192/1134 (16%)

Query: 1550 EEMFSKDKTFIVRQSI-------HDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ 1602
            EEM  K +  +  ++I         E+   + +   +L   +++LE++  +L  + +E +
Sbjct: 876  EEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE 935

Query: 1603 QATELLR------QAHMRQMERQREDQEQLQEEIK--------RLNRQLAQRSSIDNENL 1648
            +  ++L+      QAH++ +E Q +++E  +++++        ++ +   +   ++++N 
Sbjct: 936  ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 995

Query: 1649 VSERERVLLEELEALKQLSLAGRE---KLCCELRNSSTQTQNGNENQGEVEEQTFKEKEL 1705
               +E+ L+E+  A     LA  E   K   ++RN      +  E + + EE+T +E E 
Sbjct: 996  KFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055

Query: 1706 DRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS 1765
             ++  D     L ++   LQ    ++ ++ L++ K    ++  + R      D  +  ++
Sbjct: 1056 AKRKLDGETTDLQDQIAELQA---QIDELKLQLAKKEEELQGALARG-----DDETLHKN 1107

Query: 1766 SASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKV--TEEGTELSQ 1823
            +A  + R E +A +     +  +     +       D+      + +++  T + T   Q
Sbjct: 1108 NALKVVR-ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166

Query: 1824 RL-VRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAK---------- 1872
             L  +      E+    EE   N  +++Q   ++   A+ E S QLE AK          
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226

Query: 1873 ----------VTQTELMRESFRQKQEATESLKCQ-EELRERLHEESRAREQLAVELSKAE 1921
                        + +++++   + +   + L  Q +EL  ++ E  R R +LA + SK +
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286

Query: 1922 GVIDG--------------YADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQ 1967
              +D               +A +    E Q+Q+  +++    ++ L  S+R+++LE E+ 
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346

Query: 1968 QIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALE 2027
             +QE++E     ++ ++ +   ++ Q L +T+K + + L      E+ +  L K  +AL 
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQ-LADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405

Query: 2028 IDVEEQVSRFIELEQEKN---TELMDL-------RQQNQALEKQLEKMRKFL-DEQAIDR 2076
              +EE+   + +LE+ KN    EL DL       RQ    LEK+ +K  + L +E++I  
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465

Query: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQ 2136
             +  +  + E +  E++ K +   + + E      E+     K+      +L+ SK+ + 
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARAL-EEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524

Query: 2137 RDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERD 2196
            +++ E  +    LE +V E+   L    D  Q  ED K          L LEV +QA + 
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK----------LRLEVNMQAMK- 1573

Query: 2197 AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKD 2256
                             QF  +L+ ++E+ ++    L  Q +E    L++  ++  L   
Sbjct: 1574 ----------------AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVA 1617

Query: 2257 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV 2316
              +K+ + +K+ +A                I+      D++ +Q+ KLQ Q+K       
Sbjct: 1618 SKKKMEIDLKDLEAQ---------------IEAANKARDEVIKQLRKLQAQMK------- 1655

Query: 2317 IEEKNELIRDLETQIECLMSDQECVKRNREEE--IEQLNEVIEKLQQELANIGQKTSMNA 2374
                 +  R+LE   E   S  E   +++E E  ++ L   I +LQ+ELA+  +      
Sbjct: 1656 -----DYQRELE---EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707

Query: 2375 HSLSEEADSL-------------KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2421
                E AD +             K +L+  IA+   LE+++E     M  + +  ++T  
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQ---LEEELEEEQSNMELLNDRFRKTTL 1764

Query: 2422 KMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVL--TEDALKSLEN 2479
            +++ L  EL +   ER + +K  +        A   L +   EL+  L   E A+KS   
Sbjct: 1765 QVDTLNAELAA---ERSAAQKSDN--------ARQQLERQNKELKAKLQELEGAVKS--- 1810

Query: 2480 QTYFKSFEENGKGSIINLETRLLQ-------LESTVSAKDLELTQCYKQIKDMQEQGQFE 2532
               FK+     +  I  LE +L Q           V   + +L + + Q++D +      
Sbjct: 1811 --KFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQY 1868

Query: 2533 TEMLQKKIVNLQKI------VEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2580
             E ++K    ++++       EE+   A  S+ +L+  +E     + N+ +S E
Sbjct: 1869 KEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ--RELDDATEANEGLSRE 1920



 Score =  147 bits (370), Expect = 3e-34
 Identities = 267/1235 (21%), Positives = 515/1235 (41%), Gaps = 181/1235 (14%)

Query: 1593 ELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSER 1652
            ++ RQ +E Q   E L    ++  E+Q + + +L EE++R ++QL +  +I  E L +E 
Sbjct: 846  QVTRQEEELQAKDEEL----LKVKEKQTKVEGEL-EEMERKHQQLLEEKNILAEQLQAET 900

Query: 1653 ERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDV 1712
            E  L  E E ++    A +++L   L +  ++ +   E    ++ +   +K++    +D+
Sbjct: 901  E--LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNE---KKKMQAHIQDL 955

Query: 1713 PPEILSNERYALQKANNRLLKILLEVVKTTAAVE-ETIGRHVLGILDRSSKSQSSASLIW 1771
              E L  E  A QK         L++ K TA  + + +   +L + D++SK      L+ 
Sbjct: 956  E-EQLDEEEGARQK---------LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005

Query: 1772 RSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFA 1831
               AE S +    EE  +         +  ++  +D+    K  E+  +  ++  R    
Sbjct: 1006 DRIAECSSQLAEEEEKAK---NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR---- 1058

Query: 1832 GTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA----------KVTQTELMRE 1881
              ++D E  +L   I+  LQA +++L   +++   +L+ A          K    +++RE
Sbjct: 1059 --KLDGETTDLQDQIAE-LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115

Query: 1882 SFRQKQEATESLKCQEELRERLHEESR-AREQLAVELSKAEGVIDGYADEKTLFERQIQE 1940
               Q  E  E  + ++  R +  ++ R   E+L    ++ E  +D  A ++ L  ++ QE
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175

Query: 1941 KTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEK 2000
              ++   LE+E      ++Q++        EE      Q +  KA     +Q L  + ++
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235

Query: 2001 L---MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA 2057
            L   +K   +V+ ++E  R  L  QV+ L   V E     +EL ++ +    +L   +  
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295

Query: 2058 LEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEH-------QTRE 2110
            LE+  +K  KF  + A      +D  +   ++  Q+L +  R + + E        Q  E
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355

Query: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRD---IQERNEEIEKLEFRVRELEQALLVSADTF 2167
             E   N  K+     S+L  +K+++  D   I+   E  +KL      L Q L   A  +
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415

Query: 2168 QKVEDRKHFGAVEAKPELS-LEVQLQAERDAIDRKEKEITNLEEQL------------EQ 2214
             K+E  K+      + EL  L V L  +R      EK+    ++ L            E+
Sbjct: 1416 DKLEKTKN----RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471

Query: 2215 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2274
             R E E + +E + L +   ++  E+    +E E++NK  + DME         D MS++
Sbjct: 1472 DRAEAEAREKETKALSLARALE--EALEAKEEFERQNKQLRADME---------DLMSSK 1520

Query: 2275 DQHVLFGKFAQIIQEK----EVEIDQLNEQVTKLQQQLKITTDNKVIEEKN------ELI 2324
            D     GK    +++     E +++++  Q+ +L+ +L+ T D K+  E N      +  
Sbjct: 1521 DD---VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577

Query: 2325 RDLETQIECLMSDQECVKRNREEEIEQLNEVIE--KLQQELANIGQKT-SMNAHSLSEEA 2381
            RDL+T+ E      E  KR   +++ +L   +E  + Q+ LA   +K   ++   L  + 
Sbjct: 1578 RDLQTRDE----QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI 1633

Query: 2382 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVL-------KETNFKMNQLTQELFSLK 2434
            ++     D VI +   L+ Q++    E+   +          KE+  K+  L  E+  L+
Sbjct: 1634 EAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ 1693

Query: 2435 RERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSI 2494
             E  S E+ +            H  +++ EL   +T  A               +GK ++
Sbjct: 1694 EELASSERARR-----------HAEQERDELADEITNSA---------------SGKSAL 1727

Query: 2495 INLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA 2554
            ++ + RL          +  + Q  +++++ Q   +   +  +K  + +  +  E  A  
Sbjct: 1728 LDEKRRL----------EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777

Query: 2555 LVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQ 2614
              +Q    A Q+  +         ++  +  +Q L    + +  + ISAL  +I +LE Q
Sbjct: 1778 SAAQKSDNARQQLER--------QNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQ 1829

Query: 2615 VVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKT 2674
            + +       E ++   A K V   EKKL E+   +E +E++  ++ K++  +    +K 
Sbjct: 1830 LEQ-------EAKERAAANKLVRRTEKKLKEIFMQVE-DERRHADQYKEQMEKANARMKQ 1881

Query: 2675 TTELFHSNEESGFFNELEALRAESVATK--AELASYKEKAEKLQEELLVKETNM-----T 2727
                    EE       EA RA +   K   EL    E  E L  E+   +  +      
Sbjct: 1882 LKRQLEEAEE-------EATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPI 1934

Query: 2728 SLQKDLSQVRD-HLAEAKEKLSILEKEDETEVQES 2761
            S     S  R  HL  A  +LS    +D+TE + S
Sbjct: 1935 SFSSSRSGRRQLHLEGASLELS----DDDTESKTS 1965



 Score =  132 bits (332), Expect = 7e-30
 Identities = 291/1342 (21%), Positives = 559/1342 (41%), Gaps = 262/1342 (19%)

Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092
            QV+R  E  Q K+ EL+ ++++   +E +LE+M         +R+H+        Q LE+
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGELEEM---------ERKHQ--------QLLEE 888

Query: 2093 QLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE----EIEK 2148
            +  +  + Q  +E    E E++   L  K  +  E+L   E    + +ERN+    E +K
Sbjct: 889  KNILAEQLQAETE-LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK 947

Query: 2149 LEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNL 2208
            ++  +++LE+ L       QK++  K     + K ++  E+ L  ++++   KEK++  +
Sbjct: 948  MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK-KMEEEILLLEDQNSKFIKEKKL--M 1004

Query: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2268
            E+++ +   +L  + E+ + L    +I+ K+    + +LE+  K  +   ++L  A ++ 
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNL---AKIRNKQEVM-ISDLEERLKKEEKTRQELEKAKRKL 1060

Query: 2269 DAMST--QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK---ITTDNKVIEEKNEL 2323
            D  +T  QDQ          I E + +ID+L  Q+ K +++L+      D++ + + N L
Sbjct: 1061 DGETTDLQDQ----------IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110

Query: 2324 --IRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
              +R+L+ QI  L  D E  K +R +  +Q  +                      LSEE 
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRD----------------------LSEEL 1148

Query: 2382 DSLKHQLDVVIAEKLALEQQVETANE-EMTFMKNVLKETNFKMNQLTQELFSLKRERESV 2440
            ++LK +L+  + +  A +Q++ T  E E+  +K  L+E         Q++   +R   ++
Sbjct: 1149 EALKTELEDTL-DTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM--RQRHATAL 1205

Query: 2441 EKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETR 2500
            E++    E +     + L K+K  LE    E A +    Q      E   K     L+ +
Sbjct: 1206 EELSEQLEQAKRFKAN-LEKNKQGLETDNKELACEVKVLQQVKAESEHKRK----KLDAQ 1260

Query: 2501 LLQLESTVSAKD---LELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS 2557
            + +L + VS  D   +EL +              +   LQ ++ N+  ++EE        
Sbjct: 1261 VQELHAKVSEGDRLRVELAE--------------KASKLQNELDNVSTLLEE-------- 1298

Query: 2558 QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVE 2617
                 A ++  KF +D  ++ S+     +Q+  +L ++E    ++ L+ RI +LE    E
Sbjct: 1299 -----AEKKGIKFAKDAASLESQ-----LQDTQELLQEETRQKLN-LSSRIRQLE----E 1343

Query: 2618 MHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK---------QREKEKKRSPQD 2668
               SL  ++E+ E A KN+   EK++L LQ  L   +KK           E+ KK+  +D
Sbjct: 1344 EKNSLQEQQEEEEEARKNL---EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKD 1400

Query: 2669 VEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTS 2728
             E L    E     E++  +++LE  +                  +LQ+EL         
Sbjct: 1401 AEALSQRLE-----EKALAYDKLEKTK-----------------NRLQQEL--------- 1429

Query: 2729 LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI 2788
               DL+   DH  +    L   +K+ +  + E K           +S   A + D     
Sbjct: 1430 --DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS----------ISARYAEERDRAEAE 1477

Query: 2789 SSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHIS 2848
            +   +T  + +  A            EE  E   +F  + ++++        DME    S
Sbjct: 1478 AREKETKALSLARA-----------LEEALEAKEEFERQNKQLRA-------DMEDLMSS 1519

Query: 2849 ETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPEL-AHSDAYQTREICSSDSGS 2907
            + +  K  H      L++    L+  ++ +R++      EL A  DA    E+      +
Sbjct: 1520 KDDVGKNVHE-----LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574

Query: 2908 DWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSD 2967
             + + +            + R E++E       K+++ L   + +E  Q      S    
Sbjct: 1575 QFERDL------------QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS---- 1618

Query: 2968 GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL 3027
                  ++  E  L++ +A I   +  +D + K   + +A++ D  +  E     R E+ 
Sbjct: 1619 ------KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672

Query: 3028 LALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR 3087
               +     E    L +   E+  L       L +    R   +    + A E    A  
Sbjct: 1673 AQSK-----ESEKKLKSLEAEILQLQEE----LASSERARRHAEQERDELADEITNSASG 1723

Query: 3088 RS-LLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDR 3146
            +S LL E + L A++      L+ E E E+ + ELL    ++   Q+  +  EL++ +  
Sbjct: 1724 KSALLDEKRRLEARI----AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1779

Query: 3147 ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKH-LKELEAFRLEVKDKTDEVHL 3205
            A +        +    ELK++L     ELE  +K++ K  +  LEA   +++++ ++   
Sbjct: 1780 AQKSDNARQQLERQNKELKAKLQ----ELEGAVKSKFKATISALEAKIGQLEEQLEQE-- 1833

Query: 3206 LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ 3265
                 A E+  + +L    EK+  ++    E ++   +  K  +E    R  QL   LE+
Sbjct: 1834 -----AKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE 1888

Query: 3266 QKQ---LLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIR-----EMSSTLD 3317
             ++     N S++K+  QR L DA  + E G + E+  L    K R+R       SS+  
Sbjct: 1889 AEEEATRANASRRKL--QRELDDATEANE-GLSREVSTL----KNRLRRGGPISFSSSRS 1941

Query: 3318 RERELH---AQLQSSDGTGQSR 3336
              R+LH   A L+ SD   +S+
Sbjct: 1942 GRRQLHLEGASLELSDDDTESK 1963



 Score =  131 bits (330), Expect = 1e-29
 Identities = 230/1078 (21%), Positives = 469/1078 (43%), Gaps = 189/1078 (17%)

Query: 1878 LMRESFRQKQEATESLK-----CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKT 1932
            L R++F +KQ+   +LK     C   L+ R  +  R         +K + ++     + T
Sbjct: 801  LARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRV-------FTKVKPLL-----QVT 848

Query: 1933 LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA---MKAEAGP 1989
              E ++Q K + + +++++       L+E+E + QQ+ EE+ +L+ Q +A   + AEA  
Sbjct: 849  RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 908

Query: 1990 VEQQLL---QETEKLMKEKLEVQCQAEKVRDDL----QKQVKALEIDVEEQVSRFIELEQ 2042
            +  +L    QE E+++ + LE + + E+ R+ +    +K+++A   D+EEQ+      E+
Sbjct: 909  MRARLAAKKQELEEILHD-LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD-----EE 962

Query: 2043 EKNTELMDLRQQN-QALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL----KVV 2097
            E   + + L +   +A  K++E+    L++Q      E+ + +  I +   QL    +  
Sbjct: 963  EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022

Query: 2098 PRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE 2157
                 I   Q   +  L   LK++     EL  +K +L  +  +  ++I +L+ ++ EL+
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082

Query: 2158 QALLVSADTFQKV------EDRKHFGAVEAKPEL-----SLEVQLQAERDAIDRKEKEIT 2206
              L    +  Q        E      A++   EL      L+   ++E+ + ++ EK+  
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142

Query: 2207 NLEEQLEQFREELEN--------------KNEEVQQLHMQLEIQKKESTTRLQELEQEN- 2251
            +L E+LE  + ELE+              + +EV +L   LE + K    ++Q++ Q + 
Sbjct: 1143 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202

Query: 2252 -------------KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2298
                         K FK ++EK    ++  +     +  VL     Q+  E E +  +L+
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL----QQVKAESEHKRKKLD 1258

Query: 2299 EQVTKLQ------QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK-----RNREE 2347
             QV +L        +L++    K  + +NEL  ++ T +E   ++++ +K      + E 
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNEL-DNVSTLLE--EAEKKGIKFAKDAASLES 1315

Query: 2348 EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE 2407
            +++   E++++  ++  N+    S     L EE +SL+ Q +     +  LE+QV     
Sbjct: 1316 QLQDTQELLQEETRQKLNL----SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371

Query: 2408 EMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEV 2467
            ++   K  + +    +  L +    L ++ E++   Q + E +  +A D L K K  L+ 
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS--QRLEEKA--LAYDKLEKTKNRLQQ 1427

Query: 2468 VLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQE 2527
             L +D    L++Q    S          NLE +  + +  + A++  ++  Y + +D  E
Sbjct: 1428 EL-DDLTVDLDHQRQVAS----------NLEKKQKKFDQLL-AEEKSISARYAEERDRAE 1475

Query: 2528 QGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQ 2587
                E    + K ++L + +EE           LEA +E+ +  Q+ Q       R +++
Sbjct: 1476 A---EAREKETKALSLARALEE----------ALEAKEEFER--QNKQL------RADME 1514

Query: 2588 NLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL---------- 2637
            +L    +D++G ++  L      LE QV EM T L   +++++  E   L          
Sbjct: 1515 DL-MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573

Query: 2638 --------------EKEKKLL-----ELQKLLEGNEKKQRE---KEKKRSPQDVEVLKTT 2675
                          E++K+LL     EL+  LE +E+KQR      KK+   D++ L+  
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAELE-DERKQRALAVASKKKMEIDLKDLEAQ 1632

Query: 2676 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2735
             E  +   +     +L  L+A+    + EL   +   +++  +    E  + SL+ ++ Q
Sbjct: 1633 IEAANKARDE-VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQ 1691

Query: 2736 VRDHLAEAKEKLSILEKE-----DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISS 2790
            +++ LA ++      E+E     DE     S K+ + +    +L   IA Q +  L+   
Sbjct: 1692 LQEELASSERARRHAEQERDELADEITNSASGKSALLDE-KRRLEARIA-QLEEELEEEQ 1749

Query: 2791 SNQ----------TPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIE-KMQELHAA 2837
            SN           T Q+   NA +     +   S+   + + +  ++++ K+QEL  A
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGA 1807



 Score =  130 bits (327), Expect = 3e-29
 Identities = 231/1094 (21%), Positives = 464/1094 (42%), Gaps = 140/1094 (12%)

Query: 698  EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757
            E+ K+K+ +Q+ V  + EEM  +  +L +E  IL ++ + +  L  E +E++ +    ++
Sbjct: 860  ELLKVKE-KQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918

Query: 758  QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK-IHTPVSQEE---RLIFLDSIKSKS 813
            +++E  +DL+ +  + E  N IL++EKK ++  ++ +   + +EE   + + L+ + +++
Sbjct: 919  ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEA 978

Query: 814  KDSVWEKEIEILIEEN----------EDLKQQC-IQLNEEIEKQRNTFSFAEKNFEVNYQ 862
            K    E+EI +L ++N          ED   +C  QL EE EK +N      K  EV   
Sbjct: 979  KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ-EVMIS 1037

Query: 863  ELQEEYACLLKVKDDLEDSKNKQELEYK------SKLKALNEELHLQRINPTTVKMKSSV 916
            +L+E      K + +LE +K K + E        ++L+A  +EL LQ          +  
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA 1097

Query: 917  FDEDKTF-VAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI-- 973
              +D+T      L++   ++    EL E  E  K  + +  ++  DLSE+L+    E+  
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELED 1157

Query: 974  ----SFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSR 1029
                +   +E+++ K+E+E   L+    E   NH     +Q    + ++ L+ +     +
Sbjct: 1158 TLDTTAAQQELRT-KREQEVAELKKALEEETKNHE--AQIQDMRQRHATALEELSEQLEQ 1214

Query: 1030 GA--EGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL---ILDHLPSVTKESSL 1084
                + ++ K  +    ++K +  +    + +    E K+++L   + +    V++   L
Sbjct: 1215 AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274

Query: 1085 RATQPSENDKLQKELN-----VLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEK 1139
            R     +  KLQ EL+     + ++E+  ++   +A  +   L  +  + Q     +   
Sbjct: 1275 RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL 1334

Query: 1140 DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQ-ETGDEGKPLHLLIGKLQKAVSEE 1198
               +  L+EE    QE++ +E +    LE Q +  Q +  D  K +   +G ++    EE
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESL--EE 1392

Query: 1199 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED---PELQDYRYEVQDFQEN 1255
                L      L +            E+K  + D + + ++    EL D   ++ D Q  
Sbjct: 1393 AKKKLLKDAEALSQ----------RLEEKALAYDKLEKTKNRLQQELDDLTVDL-DHQRQ 1441

Query: 1256 MHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE------------ENLPKEETE 1303
            + + L K  +++++LL  +  +S  + ++ D  + E  E            E   + + E
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 1304 FLSIHSQM-TNLEDIDVNHKSKLSSLQDLEKTK--LEEQVQELESLISSLQQQLKETEQ- 1359
            F   + Q+  ++ED+  +      ++ +LEK+K  LE+QV+E+ + +  L+ +L+ TE  
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561

Query: 1360 ------NYEAEIHCLQKRLQAVSESTVPPS-LPVDSVVITESD-----AQRTMYPGSCVK 1407
                  N +A     ++ LQ   E       L +  V   E++      QR +   S  K
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621

Query: 1408 KNID-GTIEFSGEFGVKEETNIVKLLE------KQYQEQLEEEVAKVIVSMSIAFAQQTE 1460
              ID   +E   E   K    ++K L       K YQ +LEE  A    S    FAQ  E
Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA----SRDEIFAQSKE 1677

Query: 1461 LSR--------ISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKE 1512
              +        I   +E  ASS++A    +QE+    + +++    G         + + 
Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD-EITNSASGKSALLDEKRRLEA 1736

Query: 1513 EFKPLSKELGEHGKEILLSNSDPHDIPESKDCV-LTISEEMFSKDKTFIVRQSI---HDE 1568
                L +EL E    + L N          D +   ++ E  +  K+   RQ +   + E
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796

Query: 1569 ISVSSMDA--------SRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMR------ 1614
            +     +            +   E ++  + ++L ++ +E   A +L+R+   +      
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856

Query: 1615 QMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKL 1674
            Q+E +R   +Q +E++++ N ++ Q              +  LEE E     + A R KL
Sbjct: 1857 QVEDERRHADQYKEQMEKANARMKQL-------------KRQLEEAEEEATRANASRRKL 1903

Query: 1675 CCELRNSSTQTQNG 1688
              EL + +T+   G
Sbjct: 1904 QREL-DDATEANEG 1916



 Score =  126 bits (316), Expect = 5e-28
 Identities = 276/1323 (20%), Positives = 560/1323 (42%), Gaps = 293/1323 (22%)

Query: 728  IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL 787
            +++ RQEE           ELQ K E L K +KEK+  ++ +  ++E ++  L +EK  L
Sbjct: 845  LQVTRQEE-----------ELQAKDEELLK-VKEKQTKVEGELEEMERKHQQLLEEKNIL 892

Query: 788  EDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQR 847
             + L       Q E  +F ++ + +++ +  ++E+E ++ + E   ++  + N+ ++ ++
Sbjct: 893  AEQL-------QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945

Query: 848  NTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEY---KSKLKALNEELHLQR 904
                   K  + + Q+L+E+        D+ E ++ K +LE    ++K+K + EE+ L  
Sbjct: 946  -------KKMQAHIQDLEEQL-------DEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991

Query: 905  INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTK-----REKLELSQRL 959
                         D++  F+ E   M + + + +++L E+ E  K     R K E+   +
Sbjct: 992  -------------DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM--I 1036

Query: 960  SDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSL 1019
            SDL E+LK++      L +  + L  E   +  +  EL+  I+  + +  +  +    +L
Sbjct: 1037 SDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGAL 1096

Query: 1020 LDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVT 1079
                    +RG + ++ K N       K++ E +     +    ES              
Sbjct: 1097 --------ARGDDETLHKNNAL-----KVVRELQAQIAELQEDFES-------------- 1129

Query: 1080 KESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEK 1139
             E + R     +   L +EL  LK+E  D      AQ+            ++R   E E 
Sbjct: 1130 -EKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ------------ELRTKREQEV 1176

Query: 1140 DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAV---S 1196
             +   +L+EE     E +I+++++ H   L+ +  Q   ++ K     + K ++ +   +
Sbjct: 1177 AELKKALEEETK-NHEAQIQDMRQRHATALEELSEQL--EQAKRFKANLEKNKQGLETDN 1233

Query: 1197 EECSYFLQTLCSVLGEYYTPALKCEVNAED---KENSGDYISENEDPELQDYRYEVQDFQ 1253
            +E +  ++ L  V  E      K +   ++   K + GD +      EL +   ++Q+  
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV----ELAEKASKLQNEL 1289

Query: 1254 ENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313
            +N+ TLL +  ++  K       L           +L+  +E L +E  + L++ S++  
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLES---------QLQDTQELLQEETRQKLNLSSRIRQ 1340

Query: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQ---- 1369
            LE+     K+ L   Q+ E    EE  + LE  + +LQ QL +T++  + ++  ++    
Sbjct: 1341 LEE----EKNSLQEQQEEE----EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392

Query: 1370 ------KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVK 1423
                  K  +A+S+     +L  D +  T++  Q+ +          D T++   +   +
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD---------DLTVDLDHQ---R 1440

Query: 1424 EETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQ 1483
            +  + ++  +K++ + L EE      S+S  +A++ + +     ++ T +   A A+ + 
Sbjct: 1441 QVASNLEKKQKKFDQLLAEEK-----SISARYAEERDRAEAEAREKETKALSLARALEEA 1495

Query: 1484 EQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKD 1543
                                    ++ KEEF+  +K+L           +D  D+  SKD
Sbjct: 1496 ------------------------LEAKEEFERQNKQL----------RADMEDLMSSKD 1521

Query: 1544 CVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQ 1603
             V                 +++H+      ++ S++ +  E+Q+E+MR +L  + ++  Q
Sbjct: 1522 DV----------------GKNVHE------LEKSKRAL--EQQVEEMRTQL-EELEDELQ 1556

Query: 1604 ATELLR-------QAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVL 1656
            ATE  +       QA   Q ER  + +++  EE KRL   + Q   ++ E          
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL--LIKQVRELEAE---------- 1604

Query: 1657 LEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK----EKELDRKPEDV 1712
            LE+    + L++A ++K+  +L++   Q +  N+ + EV +Q  K     K+  R+ E+ 
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664

Query: 1713 PPEILSNERYALQKANNRLLKIL----LEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
                  +E +A  K + + LK L    L++ +  A+ E            R    Q    
Sbjct: 1665 RAS--RDEIFAQSKESEKKLKSLEAEILQLQEELASSERA----------RRHAEQERDE 1712

Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM------WSKVTEEGTELS 1822
            L       AS KS + +E  R+  E+  +    ++     NM      + K T +   L+
Sbjct: 1713 LADEITNSASGKSALLDEKRRL--EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770

Query: 1823 QRLV-------RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQ 1875
              L        +S  A  +++ +N+EL   +   L+ AV+   +A   T S LE AK+ Q
Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKELKAKLQE-LEGAVKSKFKA---TISALE-AKIGQ 1825

Query: 1876 TELMRESFRQKQEATESL--KCQEELRE---RLHEESRAREQLAVELSKAEGVIDGYADE 1930
             E   E   +++ A   L  + +++L+E   ++ +E R  +Q   ++ KA       A  
Sbjct: 1826 LEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKAN------ARM 1879

Query: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMK---AEA 1987
            K L +RQ++E        E+E   A+   ++L+ E     E  E LSR+   +K      
Sbjct: 1880 KQL-KRQLEEA-------EEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1931

Query: 1988 GPV 1990
            GP+
Sbjct: 1932 GPI 1934



 Score =  118 bits (296), Expect = 1e-25
 Identities = 229/1095 (20%), Positives = 454/1095 (41%), Gaps = 198/1095 (18%)

Query: 1294 EENLPKEETEFLSIHSQMTN----LEDIDVNHKSKLSSLQDLEKTKLEEQVQ---ELESL 1346
            EE L  ++ E L +  + T     LE+++  H+  L      EK  L EQ+Q   EL + 
Sbjct: 851  EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLE-----EKNILAEQLQAETELFAE 905

Query: 1347 ISSLQQQLKETEQNYEAEIHCLQKRLQAVSEST--VPPSLPVDSVVITESDAQRTMYPGS 1404
               ++ +L   +Q  E  +H L+ R++   E    +          I + + Q     G+
Sbjct: 906  AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965

Query: 1405 CVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEE--VAKVIVSMSIAFAQQTE-- 1460
              K  ++   + + E  +K+    + LLE Q  + ++E+  +   I   S   A++ E  
Sbjct: 966  RQKLQLE---KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022

Query: 1461 --LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD----------- 1507
              L++I   +E   S  +     ++E+    E++ ++ ++  +T +  D           
Sbjct: 1023 KNLAKIRNKQEVMISDLEERL--KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080

Query: 1508 --VKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE----EMFSKDKTFIV 1561
              ++  ++ + L   L     E L  N+    + E +  +  + E    E  S++K    
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140

Query: 1562 RQSIHDEI---------SVSSMDASRQLMLNEEQ-LEDMRQELVRQYQEHQQATELLRQA 1611
            ++ + +E+         ++ +  A ++L    EQ + ++++ L  + + H+   + +RQ 
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR 1200

Query: 1612 HMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGR 1671
            H   +E   E  EQ +     L +   Q    DN+ L  E     ++ L+ +K  S   R
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEKN-KQGLETDNKELACE-----VKVLQQVKAESEHKR 1254

Query: 1672 EKLCCELRNSSTQTQNGNENQGEVEEQTFK-EKELDRKPEDVPPEILSNERYALQKANNR 1730
            +KL  +++    +   G+  + E+ E+  K + ELD            N    L++A  +
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD------------NVSTLLEEAEKK 1302

Query: 1731 LLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRV 1790
             +K   +     + +++T  + +L    R   + SS       E  +  +    EE  R 
Sbjct: 1303 GIKFAKDAASLESQLQDT--QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360

Query: 1791 TDE----SIPSYSGSDMPRNDINMWS---------KVTEEGTELSQRLVRSGFAGTEIDP 1837
              E    ++ S       + D ++ +         K+ ++   LSQRL     A  +++ 
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE- 1419

Query: 1838 ENEELMLNISSRLQAAVEKL---LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK 1894
                      +RLQ  ++ L   L+   + +S LE  +    +L+ E      E + S +
Sbjct: 1420 -------KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE------EKSISAR 1466

Query: 1895 CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQE-KTDIID------- 1946
              EE R+R   E+R +E  A+ L++A   ++   + K  FERQ ++ + D+ D       
Sbjct: 1467 YAEE-RDRAEAEAREKETKALSLARA---LEEALEAKEEFERQNKQLRADMEDLMSSKDD 1522

Query: 1947 -------------RLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ 1993
                          LEQ++     +L+ELE E Q  ++ +  L    +AMKA+     Q 
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582

Query: 1994 LLQETEK----LMKEKLEVQCQAEKVRDDLQKQV---KALEIDV---EEQVSRFIELEQE 2043
              ++ E+    L+K+  E++ + E  R      V   K +EID+   E Q+    +   E
Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642

Query: 2044 KNTELMDLRQQNQALEKQLEKMRKFLDE---QAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
               +L  L+ Q +  +++LE+ R   DE   Q+ + E +    + EI +L+++L    R 
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702

Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE------------- 2147
            +    H  +E ++LA+ +       S LL  K +L+  I +  EE+E             
Sbjct: 1703 R---RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759

Query: 2148 -KLEFRVRELEQALLVSADTFQKVEDRKHF----------------GAVEAKPELSL--- 2187
             K   +V  L   L       QK ++ +                  GAV++K + ++   
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819

Query: 2188 -----EVQLQAERDA---------IDRKEKEITNLEEQLE-------QFREELENKNEEV 2226
                 +++ Q E++A         + R EK++  +  Q+E       Q++E++E  N  +
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM 1879

Query: 2227 QQLHMQLEIQKKEST 2241
            +QL  QLE  ++E+T
Sbjct: 1880 KQLKRQLEEAEEEAT 1894



 Score =  113 bits (283), Expect = 3e-24
 Identities = 197/976 (20%), Positives = 415/976 (42%), Gaps = 168/976 (17%)

Query: 2    EDEERQKKLEAGKAK---LAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNID 58
            E+EE+ K L   + K   +    + + + + ++  + +K KRK      D+     +   
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ--DQIAEL 1074

Query: 59   QSQCNEMYINSSQRVESTVIPESTIMR----TLHSGEITSHEQGFSVELESEISTTADDC 114
            Q+Q +E+ +  +++ E     +  + R    TLH        +    EL+++I+   +D 
Sbjct: 1075 QAQIDELKLQLAKKEEEL---QGALARGDDETLHKNNALKVVR----ELQAQIAELQEDF 1127

Query: 115  SSEVNGCSFVMRTGKPTNLLREE----EFGVDDSYSEQGAQDSPTHLEMMESELAGK-QH 169
             SE    +   +  K    L EE    +  ++D+     AQ           EL  K + 
Sbjct: 1128 ESEKASRN---KAEKQKRDLSEELEALKTELEDTLDTTAAQQ----------ELRTKREQ 1174

Query: 170  EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFL 229
            E+ EL + LEE    +  +     Q    A+++       L+  L+QA+R K    +   
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEE-------LSEQLEQAKRFKANLEKNKQ 1227

Query: 230  ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQK 289
             L   +++L  + + LQ  +    S H     D      Q+     ++ E D L  +  +
Sbjct: 1228 GLETDNKELACEVKVLQ--QVKAESEHKRKKLDA-----QVQELHAKVSEGDRLRVELAE 1280

Query: 290  KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK 349
            K      ++  +   ++  E +  K  +++   E Q ++T  +EL   + EE ++ L L 
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT--QEL---LQEETRQKLNLS 1335

Query: 350  DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409
             ++   ++    LQEQ  ++ +  KN++ ++   + +   + +++   +GT+E L++   
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395

Query: 410  KDSQFETDIVQRMEQET------QRKLEQLRAELDEM-----YGQQI---VQMKQELIRQ 455
            K  +    + QR+E++       ++   +L+ ELD++     + +Q+   ++ KQ+   Q
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 456  HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA----------------INELN 499
             +A+ + +  R+  E + A          E + K +++A                  +L 
Sbjct: 1456 LLAEEKSISARYAEERDRA-----EAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510

Query: 500  IKLQDTNSQKEKLKEELGLILEEKCALQR-------QLEDLVEELSFSRE---------- 542
              ++D  S K+ + + +  + + K AL++       QLE+L +EL  + +          
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 543  ----QIQRARQTIAEQESKLNEAHKSL--STVEDLKAEIVSASESRKELEL------KHE 590
                Q +R  QT  EQ    NE  K L    V +L+AE+    + RK+  L      K E
Sbjct: 1571 AMKAQFERDLQTRDEQ----NEEKKRLLIKQVRELEAEL---EDERKQRALAVASKKKME 1623

Query: 591  AEVTNYKIKLEMLEKEKNAVLDRMAESQ------EAELERLRTQL--LFSHEEELSKLKE 642
             ++ + + ++E   K ++ V+ ++ + Q      + ELE  R     +F+  +E  K  +
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683

Query: 643  DLEIEHRINIEKLKDNLGI--HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS 700
             LE E    I +L++ L      ++  +  ++E++ +I      K  L+ ++ +L   I+
Sbjct: 1684 SLEAE----ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIA 1739

Query: 701  KLKD------LQQSLVNSKSEEMTLQINELQKEIEILR----QEEKEKGTLEQEVQELQL 750
            +L++          L+N +  + TLQ++ L  E+   R    + +  +  LE++ +EL+ 
Sbjct: 1740 QLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKA 1799

Query: 751  KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
            K + LE  +K K    +   + LEA+   L+++   LE   K     ++  R        
Sbjct: 1800 KLQELEGAVKSK---FKATISALEAKIGQLEEQ---LEQEAKERAAANKLVRRT------ 1847

Query: 811  SKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC 870
                    EK+++ +  + ED ++   Q  E++EK        ++  E   +E     A 
Sbjct: 1848 --------EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899

Query: 871  LLKVKDDLEDSKNKQE 886
              K++ +L+D+    E
Sbjct: 1900 RRKLQRELDDATEANE 1915



 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 242/1190 (20%), Positives = 468/1190 (39%), Gaps = 209/1190 (17%)

Query: 2726 MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGT 2785
            +T  +++L    + L + KEK +  + E E E  E K   + E   I L++ + ++T+  
Sbjct: 847  VTRQEEELQAKDEELLKVKEKQT--KVEGELEEMERKHQQLLEEKNI-LAEQLQAETE-- 901

Query: 2786 LKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR 2845
            L   +     ++  K              +E+ EI+     ++E+ +E +  +IL  E +
Sbjct: 902  LFAEAEEMRARLAAKK-------------QELEEILHDLESRVEEEEERN--QILQNEKK 946

Query: 2846 ----HISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREIC 2901
                HI + E    E   A Q L+ E  T +A I+  + +E   + E  +S   + +++ 
Sbjct: 947  KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK--KMEEEILLLEDQNSKFIKEKKLM 1004

Query: 2902 SSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLT 2961
                                    E R  E  S      +K K L +  + + + +  L 
Sbjct: 1005 ------------------------EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE 1040

Query: 2962 ESPYSDGEDHSIQQVSEPWLEERKAYIN-TISSLKDLITKMQLQREAEVYDSSQSHESFS 3020
            E      E+ + Q+     LE+ K  ++   + L+D I ++Q Q +              
Sbjct: 1041 ERLKK--EEKTRQE-----LEKAKRKLDGETTDLQDQIAELQAQID-------------- 1079

Query: 3021 DWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAME 3080
                EL L L +   +E  +  A  R +   L   +A+ ++  L+ +I E   ++++   
Sbjct: 1080 ----ELKLQLAK---KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132

Query: 3081 CLQKADR--RSLLSEIQALHAQMNGRKITLKREQE-SEKPSQELLEYNIQQKQSQMLEMQ 3137
               KA++  R L  E++AL  ++     T   +QE   K  QE+ E   +  + +    +
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK-KALEEETKNHE 1191

Query: 3138 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3197
             ++  M+ R     E+LS +       K+ L + K  LET  K     +K L+  + E +
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251

Query: 3198 DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS--------EERDKEELEDLK--F 3247
             K  ++      L ++  +   L+  L ++ +KL           EE +K+ ++  K   
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311

Query: 3248 SLESQKQRNLQLNLLLEQQKQLLNES---QQKIESQRMLYDAQLSEEQGR-NLELQVL-- 3301
            SLESQ Q   +  LL E+ +Q LN S   +Q  E +  L + Q  EE+ R NLE QVL  
Sbjct: 1312 SLESQLQDTQE--LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLAL 1369

Query: 3302 --------------------LESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS 3341
                                LE  K ++ + +  L +  E  A         ++R     
Sbjct: 1370 QSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429

Query: 3342 EDLLKELQKQ------LEEKHSRIVELL-----------------------NETEKYKL- 3371
            +DL  +L  Q      LE+K  +  +LL                        ET+   L 
Sbjct: 1430 DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489

Query: 3372 ----DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 3427
                ++L+ +++ E+  +  R  ++    +  +  K +HEL+     L++Q+EE R Q+ 
Sbjct: 1490 RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549

Query: 3428 KLDLEGQ-------RLQGIMQEFQKQ-----ELEREEKRESRRILYQNLNEPTTWSLTSD 3475
            +L+ E Q       RL+  MQ  + Q     +   E+  E +R+L + + E     L  +
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA-ELEDE 1608

Query: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3535
            R      Q+ +   +K+     L ++       N   + + ++L+ + ++++   ++  E
Sbjct: 1609 RK-----QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEE 1663

Query: 3536 RLQFETADDEDFIWVQE------NIDEIILQLQKLTGQ--------QGEEPSLVSPSTSC 3581
                  + DE F   +E      +++  ILQLQ+            + E   L    T+ 
Sbjct: 1664 A---RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720

Query: 3582 GSLTERLLRQNAELTGHISQLTEEKND-------LRNMVMKLEEQIRWYRQTGAGRDNSS 3634
             S    LL +   L   I+QL EE  +       L +   K   Q+       A   +++
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780

Query: 3635 RFSLNGGANIE----AIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLS 3690
            + S N    +E     + A  +E+    K   + ++   EA++ +L+ +L  ++  +  +
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840

Query: 3691 PDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFT 3750
                  T K++   +++ E  R+     K+ +        E  +A +  L R   +    
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYKEQM--------EKANARMKQLKRQLEEAEEE 1892

Query: 3751 DLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDG 3800
                  +R K       A   +  +SR    ++   R  G +S + +R G
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSG 1942



 Score = 96.7 bits (239), Expect = 4e-19
 Identities = 239/1169 (20%), Positives = 474/1169 (40%), Gaps = 183/1169 (15%)

Query: 1105 EQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEE--KIKELQ 1162
            +Q  L      QR C + +   H    R + + +    +   +EEL    EE  K+KE Q
Sbjct: 809  KQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQ 868

Query: 1163 KIHQLELQTM--KTQETGDEGKPLHLLIGKLQK-----AVSEECSYFLQTLCSVLGEYYT 1215
               + EL+ M  K Q+  +E    ++L  +LQ      A +EE    L      L E   
Sbjct: 869  TKVEGELEEMERKHQQLLEEK---NILAEQLQAETELFAEAEEMRARLAAKKQELEEILH 925

Query: 1216 PALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT--------LLNKVTEEY 1267
              L+  V  E++ N    I +NE  ++Q +   +QD +E +           L KVT E 
Sbjct: 926  D-LESRVEEEEERNQ---ILQNEKKKMQAH---IQDLEEQLDEEEGARQKLQLEKVTAEA 978

Query: 1268 N------KLLVLQTRLSK-IWGQQTDGMKLEFGEENLPKEETEFLSI----HSQMTNLED 1316
                   ++L+L+ + SK I  ++    ++      L +EE +  ++    + Q   + D
Sbjct: 979  KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISD 1038

Query: 1317 IDVNHKSKLSSLQDLEKTK---------LEEQVQELESLISSLQQQLKETEQNYEAEI-H 1366
            ++   K +  + Q+LEK K         L++Q+ EL++ I  L+ QL + E+  +  +  
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098

Query: 1367 CLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEET 1426
               + L   +   V   L      + E             K+  D + E        E+T
Sbjct: 1099 GDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDT 1158

Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVC----- 1481
                  +++ + + E+EVA+    +  A  ++T+       +      +Q HA       
Sbjct: 1159 LDTTAAQQELRTKREQEVAE----LKKALEEETK-----NHEAQIQDMRQRHATALEELS 1209

Query: 1482 -QQEQHYFNEMKLSQDQIGFQTFE---TVDVKFKEEFKPLS----KELGEHGKEILLSNS 1533
             Q EQ    +  L +++ G +T       +VK  ++ K  S    K+L    +E+    S
Sbjct: 1210 EQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS 1269

Query: 1534 D-----------PHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLML 1582
            +              +    D V T+ EE   K   F       D  S+ S     Q +L
Sbjct: 1270 EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA-----KDAASLESQLQDTQELL 1324

Query: 1583 NEEQLEDMR-QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRS 1641
             EE  + +     +RQ +E + + +        Q E + E ++ L++++  L  QLA   
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQ-------EQQEEEEEARKNLEKQVLALQSQLADTK 1377

Query: 1642 SIDNENL-----VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE 1696
               +++L     + E ++ LL++ EAL Q      EK     +   T+    N  Q E++
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRL---EEKALAYDKLEKTK----NRLQQELD 1430

Query: 1697 EQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGI 1756
            + T    +LD + +     + SN    L+K   +  ++L E    +A   E   R     
Sbjct: 1431 DLTV---DLDHQRQ-----VASN----LEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478

Query: 1757 LDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRN--DINMWSKV 1814
             ++ +K+ S A  +     EA  +     +  R   E + S S  D+ +N  ++    + 
Sbjct: 1479 REKETKALSLARAL-EEALEAKEEFERQNKQLRADMEDLMS-SKDDVGKNVHELEKSKRA 1536

Query: 1815 TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSR-LQAAVEKLLEAISETSSQLEHAKV 1873
             E+  E   R             E+ +L L ++ + ++A  E+ L+   E + + +   +
Sbjct: 1537 LEQQVE-EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595

Query: 1874 TQT-EL---MRESFRQKQEATESLKCQE----ELRERLHEESRAREQLAVELSKAEGVID 1925
             Q  EL   + +  +Q+  A  S K  E    +L  ++   ++AR+++  +L K +  + 
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655

Query: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985
             Y       +R+++E     D +  +   +  +L+ LEAE  Q+QEE     R +   + 
Sbjct: 1656 DY-------QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708

Query: 1986 EAGPVEQQLLQETE---KLMKEKLEVQCQAEKVRDDLQKQVKALEI-------------D 2029
            E   +  ++         L+ EK  ++ +  ++ ++L+++   +E+              
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT 1768

Query: 2030 VEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR-----KF-------------LDE 2071
            +  +++      Q+ +     L +QN+ L+ +L+++      KF             L+E
Sbjct: 1769 LNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE 1828

Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131
            Q      ER    + +++ E++LK +  F  + + +       A+  KE+ +K +  +  
Sbjct: 1829 QLEQEAKERAAANKLVRRTEKKLKEI--FMQVEDERRH-----ADQYKEQMEKANARM-- 1879

Query: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQAL 2160
             +QL+R ++E  EE  +     R+L++ L
Sbjct: 1880 -KQLKRQLEEAEEEATRANASRRKLQREL 1907



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 259/1248 (20%), Positives = 500/1248 (40%), Gaps = 244/1248 (19%)

Query: 908  TTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLK 967
            T VK    V  +++   A+  E+ +V EK T ++  +LE  +R+  +L +  + L+EQL 
Sbjct: 839  TKVKPLLQVTRQEEELQAKDEELLKVKEKQT-KVEGELEEMERKHQQLLEEKNILAEQL- 896

Query: 968  QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027
            Q   E+    EE+++    K+Q      ELE I+ H+    V+  + +            
Sbjct: 897  QAETELFAEAEEMRARLAAKKQ------ELEEIL-HDLESRVEEEEER------------ 937

Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT 1087
                       N+    E K M       E     EE  +++L L+    VT E+ ++  
Sbjct: 938  -----------NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE---KVTAEAKIK-- 981

Query: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147
                  K+++E+ +L+ + +    + +     ++   S    Q+ E  E  K+ A    K
Sbjct: 982  ------KMEEEILLLEDQNSKFIKEKKLMEDRIAECSS----QLAEEEEKAKNLAKIRNK 1031

Query: 1148 EELIFAQ-EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206
            +E++ +  EE++K+ +K  Q EL+  K +  G E   L   I +LQ  + E         
Sbjct: 1032 QEVMISDLEERLKKEEKTRQ-ELEKAKRKLDG-ETTDLQDQIAELQAQIDE--------- 1080

Query: 1207 CSVLGEYYTPALKCEVNAEDKENSGDYISENEDP-----------ELQDYRYEVQDFQEN 1255
                       LK ++  +++E  G     +++            ELQ    E+Q+  E+
Sbjct: 1081 -----------LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129

Query: 1256 MHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENL-PKEETEFLSIHSQMTNL 1314
                 NK  ++   L      L  +  +  D +     ++ L  K E E   +      L
Sbjct: 1130 EKASRNKAEKQKRDL---SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA---L 1183

Query: 1315 EDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEA---EIHCLQKR 1371
            E+   NH++++  ++    T LEE  ++LE      +  L++ +Q  E    E+ C  K 
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQA-KRFKANLEKNKQGLETDNKELACEVKV 1242

Query: 1372 LQAVSESTVPPSLPVDSVV------ITESDAQRTMYPGSCVK-----KNIDGTIEFSGEF 1420
            LQ V   +      +D+ V      ++E D  R        K      N+   +E + + 
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK 1302

Query: 1421 GVKEETNIVKLLEKQYQE--QLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
            G+K   +   L E Q Q+  +L +E  +  +++S         SRI   +E   S ++  
Sbjct: 1303 GIKFAKDAASL-ESQLQDTQELLQEETRQKLNLS---------SRIRQLEEEKNSLQE-- 1350

Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
               QQE+       L +  +  Q+ +  D K K +    + E  E  K+ LL +++    
Sbjct: 1351 ---QQEEEEEARKNLEKQVLALQS-QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS- 1405

Query: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEIS--VSSMDASRQLMLNEEQLEDMRQELV- 1595
                     + E+  + DK    +  +  E+      +D  RQ+  N E+ +    +L+ 
Sbjct: 1406 -------QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458

Query: 1596 -------RQYQEHQQATELLRQAHMRQMERQREDQEQLQ--EEIKRLNRQLAQRSSIDNE 1646
                   R  +E  +A    R+   + +   R  +E L+  EE +R N+QL      D E
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA----DME 1514

Query: 1647 NLVSERERV--LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQG--EVEEQTFK- 1701
            +L+S ++ V   + ELE  K+      E++  +L     + Q   + +   EV  Q  K 
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574

Query: 1702 --EKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDR 1759
              E++L  + E               +   RLL  + +V +  A +E+   +  L +   
Sbjct: 1575 QFERDLQTRDEQ-------------NEEKKRLL--IKQVRELEAELEDERKQRALAV--- 1616

Query: 1760 SSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGT 1819
            +SK +    L    + EA +++       +  DE I                 K+  +  
Sbjct: 1617 ASKKKMEIDL---KDLEAQIEAA-----NKARDEVIKQLR-------------KLQAQMK 1655

Query: 1820 ELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELM 1879
            +  + L  +  +  EI  +++E    + S L+A + +L E ++ +     HA+  + EL 
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKS-LEAEILQLQEELASSERARRHAEQERDELA 1714

Query: 1880 RESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ 1939
             E        +  L  +  L  R+   ++  E+L  E S  E           L   + +
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARI---AQLEEELEEEQSNME-----------LLNDRFR 1760

Query: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQIQEE-RELLSRQKE--------------AMK 1984
            + T  +D L  EL    +  Q+ +  +QQ++ + +EL ++ +E              A++
Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820

Query: 1985 AEAGPVEQQLLQE-------------TEKLMKEKL----EVQCQAEKVRDDLQK------ 2021
            A+ G +E+QL QE             TEK +KE      + +  A++ ++ ++K      
Sbjct: 1821 AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880

Query: 2022 QVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
            Q+K    + EE+ +R     ++   EL D  + N+ L +++  ++  L
Sbjct: 1881 QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRL 1928



 Score = 56.6 bits (135), Expect = 5e-07
 Identities = 84/384 (21%), Positives = 165/384 (42%), Gaps = 48/384 (12%)

Query: 3345 LKELQKQLEEKHSRIVELLNETEKY-----KLDSLQTR-QQMEKDRQVHRKTLQTEQEAN 3398
            L ++ +Q EE  ++  ELL   EK      +L+ ++ + QQ+ +++ +  + LQ E E  
Sbjct: 844  LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903

Query: 3399 TEGQK-------KMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451
             E ++       K  EL+  + DL+ ++EE+ ++   L  E +++Q  +Q+ ++Q  E E
Sbjct: 904  AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963

Query: 3452 EKRESRRI-------LYQNLNEPTTWSLTSDRTRNWVLQQKI-------------EGETK 3491
              R+  ++         + + E     L  D+   ++ ++K+             E E K
Sbjct: 964  GARQKLQLEKVTAEAKIKKMEEEIL--LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021

Query: 3492 ESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFI-WV 3550
              N AK+             +  + ++L+      Q L +KA  +L  ET D +D I  +
Sbjct: 1022 AKNLAKIRNKQ------EVMISDLEERLKKEEKTRQEL-EKAKRKLDGETTDLQDQIAEL 1074

Query: 3551 QENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLR 3610
            Q  IDE+ LQL K   ++ E    ++            L+   EL   I++L E+    +
Sbjct: 1075 QAQIDELKLQLAK---KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131

Query: 3611 NMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE 3670
                K E+Q R   +           +L+  A  + +    ++     K  L++  K  E
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191

Query: 3671 AEVYKLKAELRNDSLLQTLSPDSE 3694
            A++  ++   R+ + L+ LS   E
Sbjct: 1192 AQIQDMRQ--RHATALEELSEQLE 1213


>gi|148536869 ninein isoform 2 [Homo sapiens]
          Length = 2133

 Score =  157 bits (398), Expect = 1e-37
 Identities = 391/1990 (19%), Positives = 824/1990 (41%), Gaps = 324/1990 (16%)

Query: 1032 EGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESS-LRATQPS 1090
            +G+++    +   E++++V  K S     +     + + +L+ +  V +E   LR    S
Sbjct: 334  DGNINLTELTLALENELLVT-KNSIHQAALASFKAEIRHLLERVDQVVREKEKLR----S 388

Query: 1091 ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEEL 1150
            + DK +K  +++ SE +D    +E +            +     ++ E  + + +LK EL
Sbjct: 389  DLDKAEKLKSLMASEVDDHHAAIERRN-----------EYNLRKLDEEYKERIAALKNEL 437

Query: 1151 IFAQEEKIKELQKIH---QLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLC 1207
               +E+ +++  K     + E++  KT+E     + L L + +  +  +E     L    
Sbjct: 438  RKEREQILQQAGKQRLELEQEIEKAKTEENYIRDR-LALSLKENSRLENE-----LLENA 491

Query: 1208 SVLGEYYTPALKCEVNAED--KENSGDYISENEDPELQDYRYEVQ--DFQENMHTLLNKV 1263
              L EY     K + N E+   E  GD    + +  LQ+ R      +++     L ++V
Sbjct: 492  EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQV 551

Query: 1264 TEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF------------------- 1304
             E       LQ+ L +   Q   G  L    +N P EE E                    
Sbjct: 552  DE-------LQSELEEYRAQ---GRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601

Query: 1305 -LSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEA 1363
             +SI +++  +E +   H   +  L+   + K+    ++L+  + S ++  +  +Q +E 
Sbjct: 602  NMSIEAELV-IEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660

Query: 1364 EIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVK 1423
            E H L+K++  +        L   + V+ E+  + T       KK +   +E       +
Sbjct: 661  ETHTLEKQISDLKNEIA--ELQGQAAVLKEAHHEATCRHEE-EKKQLQVKLE-------E 710

Query: 1424 EETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQ 1483
            E+T++ + L  Q++ +L+  + +           Q    R   G +++A +++      Q
Sbjct: 711  EKTHLQEKLRLQHEMELKARLTQA----------QASFEREREGLQSSAWTEEKVRGLTQ 760

Query: 1484 EQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH----DIP 1539
            E   F++ +L+   +   T E  +++ KE  +   +EL E G+E + +  +      +  
Sbjct: 761  ELEQFHQEQLT-SLVEKHTLEKEELR-KELLEKHQRELQE-GREKMETECNRRTSQIEAQ 817

Query: 1540 ESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQ 1599
               DC   ++E   S        QS+         D   Q    + Q E  + EL    Q
Sbjct: 818  FQSDC-QKVTERCES------ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT---Q 867

Query: 1600 EHQQATELLRQAHMRQMERQ---REDQEQLQEEIK-RLNRQLAQRSSI--DNENL--VSE 1651
            E  +A ELL++   R+        +++E L++  K  LN  + +R  +  D E+L  VSE
Sbjct: 868  ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927

Query: 1652 RERVLLE----ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDR 1707
             ++ LL     EL++  +  L  RE++ C         Q G   Q   +     E E D+
Sbjct: 928  TQQSLLSDQILELKSSHKRELREREEVLC---------QAGASEQLASQRLERLEMEHDQ 978

Query: 1708 KPEDVPPEILSNE---RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQ 1764
            + +++  ++L+ E   +   + A+    ++  E+ +  + ++E     +       S  Q
Sbjct: 979  ERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKE-----MQQATSPLSMLQ 1033

Query: 1765 SSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQR 1824
            S   +I   E E                         D   + +    ++ EE  ++   
Sbjct: 1034 SGCQVIGEEEVE------------------------GDGALSLLQQGEQLLEENGDVLLS 1069

Query: 1825 LVRSGFAGTEIDPENEELMLNISSRLQAAVEKL------LEAISETSSQLEHAKVTQTEL 1878
            L R   A  +   EN ++   I SRLQ  ++KL         + E +++       QTE 
Sbjct: 1070 LQR---AHEQAVKENVKMATEI-SRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEP 1125

Query: 1879 MRESFRQKQ-------EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEK 1931
              +  R KQ            L+  +E+R+     + + ++  V++ ++E  ++G+++ +
Sbjct: 1126 FLQQNRTKQVEGVTRRHVLSDLE-DDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELE 1184

Query: 1932 TLFERQIQ--EKTDIIDRLEQEL--LC-----ASNRLQELEAEQQQIQEERELLSRQKEA 1982
               E + +  E  + I +L+++L  LC     AS + Q+L  +   ++++ ++L R  EA
Sbjct: 1185 NSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEA 1244

Query: 1983 -----MKAEAGPVEQQLLQETEKLMKEKL--------EVQCQAEKVRDDLQKQVKALEID 2029
                 +  E    E   LQE  ++M+ +         E+  +  +++D+L+K        
Sbjct: 1245 SPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKK-------- 1296

Query: 2030 VEEQVSRFIELEQ---EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQE 2086
            +EE    F+ LE+   E   E  +L      L+ ++EK+++ + ++      E  +   E
Sbjct: 1297 MEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLE 1356

Query: 2087 IQ------KLEQQL-KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDI 2139
            I+      +L Q L + VPR + +  H   E +Q   +L+  T      LL K +   +I
Sbjct: 1357 IEPDGNILQLNQTLEECVPRVRSV-HHVIEECKQENQYLEGNTQ-----LLEKVK-AHEI 1409

Query: 2140 QERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLE-VQLQ------ 2192
               +  I+  + R R   Q +L    T    +D KHF       EL LE  +LQ      
Sbjct: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQD-KHFQHQATIAELELEKTKLQELTRKL 1468

Query: 2193 AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK 2252
             ER  I  K+K++ +  E+ E+ +  + +      ++  ++E+ + ES    ++L+QEN 
Sbjct: 1469 KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES----EKLQQENS 1524

Query: 2253 LFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK--- 2309
            + ++++  L     E D++S      L G   ++ Q+ E  + Q N  V K+ + LK   
Sbjct: 1525 ILRNEITTL----NEEDSISNLKLGTLNGSQEEMWQKTET-VKQENAAVQKMVENLKKQI 1579

Query: 2310 ---------ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2360
                     +  +N  + +KN   ++   ++   +++  C     ++E E  N  +E+ +
Sbjct: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLC-----QKEKEPGNSALEERE 1634

Query: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2420
            QE  N+ ++        S    SL+ +L  V  +   ++Q+     +E+  MK + +  +
Sbjct: 1635 QEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPD 1694

Query: 2421 FKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDK-PELEVVLTEDALKSLEN 2479
              ++   Q++ S+    E + K +      +N  +D L+K    E  +   +   KS E+
Sbjct: 1695 --LSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEH 1752

Query: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
            Q+       + K  ++  + ++  LE TV   +L++++    ++  Q+    E E L+++
Sbjct: 1753 QS------ASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ----EKEALKQE 1802

Query: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYA-KFCQDNQTISSEPERTNIQNLNQLREDELG 2598
            +++L K            Q+Q    + +A +       + ++ +R +   L+ L  +E  
Sbjct: 1803 VMSLHK------------QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQ- 1849

Query: 2599 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLL---------ELQKL 2649
                 L      L++ V      L   +E+V   E N+L K +K L         E +KL
Sbjct: 1850 ---QLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL 1906

Query: 2650 LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYK 2709
                E  Q +KE+  + + V  + +  +            ELE +  E+          K
Sbjct: 1907 SLKRECDQFQKEQSPANRKVSQMNSLEQ------------ELETIHLEN-------EGLK 1947

Query: 2710 EKAEKLQEELL-VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE 2768
            +K  KL E+L+ ++    T+         D     ++   ++ +E   ++Q  ++    E
Sbjct: 1948 KKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ--RQLLQAE 2005

Query: 2769 PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI 2828
             +   L + + ++T  T     + +    +++   I++  + +     + E ++Q  E++
Sbjct: 2006 RINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065

Query: 2829 EK-------MQELHAAEILDMESRHISE--TETLKREHYVAVQLLKEECGTLKAVIQCLR 2879
             K       +++L+      +++  ++E   +T ++++Y    LL+E+  +L  +++ L 
Sbjct: 2066 CKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNY----LLEEKIASLSNIVRNLT 2121

Query: 2880 SKEGSSIPEL 2889
                +S P L
Sbjct: 2122 PAPLTSTPPL 2131



 Score =  148 bits (373), Expect = 1e-34
 Identities = 401/1989 (20%), Positives = 803/1989 (40%), Gaps = 273/1989 (13%)

Query: 666  QIDGLQNEMSQKIETMQFEKD-NLITKQNQLILE----ISKLKDLQQSLVNSKSEEMTL- 719
            Q +G++N   + ++ + F  D N+   +  L LE    ++K    Q +L + K+E   L 
Sbjct: 315  QEEGIENSQ-EILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLL 373

Query: 720  -QINELQKEIEILRQE----EKEKGTLEQEVQELQLKTELL-EKQMKEKENDLQEKFAQL 773
             +++++ +E E LR +    EK K  +  EV +     E   E  +++ + + +E+ A L
Sbjct: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433

Query: 774  EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK 833
            +  N + K+ ++ L+   K    + QE         K+K++++     + + ++EN  L+
Sbjct: 434  K--NELRKEREQILQQAGKQRLELEQEIE-------KAKTEENYIRDRLALSLKENSRLE 484

Query: 834  QQCIQLNEEIEKQRNTFSFAEKNFE----VNYQELQEEYACLLKVKDDLEDSKNKQELEY 889
             + ++  E++ +  N  +  ++N E      + +L    A     ++ L   +N+ E + 
Sbjct: 485  NELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 544

Query: 890  K---SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
            +    ++  L  EL   R     +++        K   +E +E          E    L 
Sbjct: 545  RVLQDQVDELQSELEEYRAQGRVLRLPL------KNSPSEEVE----ANSGGIEPEHGLG 594

Query: 947  VTKREKLELSQRLSDLSEQLKQKHGEISF-----LNEEVKSLKQEKEQVSLRCRELEIII 1001
              +   L +S     + EQ+K++H          L ++V+  +++ ++  + C++ +  +
Sbjct: 595  SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM 654

Query: 1002 NHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061
                     + + Q+S L + +  +  + A      V K    E+    E          
Sbjct: 655  KQRHENETHTLEKQISDLKNEIAELQGQAA------VLKEAHHEATCRHE---------- 698

Query: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICL- 1120
             EE KQ Q+ L+             T   E  +LQ E+  LK+     +   E +R  L 
Sbjct: 699  -EEKKQLQVKLEE----------EKTHLQEKLRLQHEME-LKARLTQAQASFEREREGLQ 746

Query: 1121 -SLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179
             S      V  + + +E    + L SL E+    +EE  KEL + HQ ELQ  + +   +
Sbjct: 747  SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806

Query: 1180 EGKPLHLLIGKLQ---KAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE 1236
              +    +  + Q   + V+E C   LQ+    L   Y   LK ++  + +E    +  E
Sbjct: 807  CNRRTSQIEAQFQSDCQKVTERCESALQS----LEGRYRQELK-DLQEQQREEKSQW--E 859

Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR--LSKIWGQQTDGMKLEFGE 1294
             E  EL     E  + QE +   L +  E+   L++ Q R  L K + +  + M +E  +
Sbjct: 860  FEKDELTQ---ECAEAQELLKETLKR--EKTTSLVLTQEREMLEKTYKEHLNSMVVERQQ 914

Query: 1295 ENLPKEETEFLSIHSQMTNLED----IDVNHKSKLSSLQD-LEKTKLEEQV--QELESLI 1347
                 E+   +S  +Q + L D    +  +HK +L   ++ L +    EQ+  Q LE L 
Sbjct: 915  LLQDLEDLRNVS-ETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLE 973

Query: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK 1407
                Q+ +E      A  +  +   +         S  +  +     + Q+   P S ++
Sbjct: 974  MEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1033

Query: 1408 KNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG 1467
                   +  GE  V+ +  +  L   Q  EQL EE   V++S+  A  Q          
Sbjct: 1034 SG----CQVIGEEEVEGDGALSLL---QQGEQLLEENGDVLLSLQRAHEQAV-------- 1078

Query: 1468 KENTASSKQAHAVCQQEQHYFNEMKLSQ--DQIGFQTFETVDVKFKEEFKPL-----SKE 1520
            KEN   + +   + Q+ Q     + +S   D+   + F        E+ +P      +K+
Sbjct: 1079 KENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNT----AEQTEPFLQQNRTKQ 1134

Query: 1521 LGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQL 1580
            +    +  +LS+ +  ++            ++ S   + + RQ +  E S +S++   +L
Sbjct: 1135 VEGVTRRHVLSDLEDDEV-----------RDLGSTGTSSVQRQEVKIEESEASVEGFSEL 1183

Query: 1581 MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR 1640
              N E+      EL  Q  + Q+   +L        +R  E ++ L  ++  L ++L   
Sbjct: 1184 E-NSEETRTESWELKNQISQLQEQLMML----CADCDRASEKKQDLLFDVSVLKKKLKML 1238

Query: 1641 SSIDNENLVSERERVLLEELEALKQLSLAGREKLCC--ELRNSSTQTQNGNENQGEVEEQ 1698
              I      S + ++L E++          RE  C   ELR   T+     EN  E+  +
Sbjct: 1239 ERIPE---ASPKYKLLYEDV---------SRENDCLQEELRMMETRYDEALENNKELTAE 1286

Query: 1699 TFKEKELDRKPEDVPPEILSNER-YALQKANNRLLKILLEVVKTTAAVEETIGRHVLGIL 1757
             F+ ++  +K E+V    LS E+ Y   K  N  L +L  V++    +E+          
Sbjct: 1287 VFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIEKL--------- 1335

Query: 1758 DRSSKSQSSASLIWRSEAEASVKSCVHE------EHTRVTDESIPSYSGSDMPRNDINMW 1811
             + S  Q     +W    EAS+++   E      +  +  +E +P          +    
Sbjct: 1336 -QESVVQRCDCCLW----EASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE 1390

Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH- 1870
            ++  E  T+L +++     A      +  +    + +  Q  +E+    +       +H 
Sbjct: 1391 NQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQN--QVILEENTTLLGFQDKHFQHQ 1448

Query: 1871 AKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930
            A + + EL         E T+  +   +L+ER+    + ++ L+    + E  +     +
Sbjct: 1449 ATIAELEL---------EKTKLQELTRKLKERVTILVKQKDVLS--HGEKEEELKAMMHD 1497

Query: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
              +   ++Q+K +++ R E E L   N +  L  E   + EE  + + +   +       
Sbjct: 1498 LQITCSEMQQKVELL-RYESEKLQQENSI--LRNEITTLNEEDSISNLKLGTLNGS---- 1550

Query: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
            ++++ Q+TE + +E   VQ    K+ ++L+KQ+  L+I  ++      EL Q+ +     
Sbjct: 1551 QEEMWQKTETVKQENAAVQ----KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEK 1606

Query: 2051 LRQQNQALEKQLEKMRKFLDEQAI-DREHERDVFQQEIQ--KLEQQLKVVPRFQPISE-- 2105
            L++ NQ L + L +  K     A+ +RE E+   ++E++  K++    V      +SE  
Sbjct: 1607 LQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVK 1666

Query: 2106 HQTREVEQLANHLKEKTDKCSEL-----LLSKEQLQRDIQERNEEI--------EKLEFR 2152
             QT  V+Q  + LK++ +K  +L     L   +Q    +   NE++        E+L   
Sbjct: 1667 IQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSC 1726

Query: 2153 VRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2212
            V +L ++ L+        +++K +    A    SL+ QL A ++ +   E  + N+  Q+
Sbjct: 1727 VDKLAKSSLLEHRIATMKQEQKSWEHQSA----SLKSQLVASQEKVQNLEDTVQNVNLQM 1782

Query: 2213 EQFREEL-------ENKNEEVQQLHMQLE-----IQKKESTTRLQELEQENKLFKDDMEK 2260
             + + +L       E   +EV  LH QL+         E  T    L  + K    D  K
Sbjct: 1783 SRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWD--K 1840

Query: 2261 LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL---------KIT 2311
            L   + E   +  Q+      +   ++Q  + E+    E+V +L+  L            
Sbjct: 1841 LDHLMNEEQQLLWQENE----RLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSG 1896

Query: 2312 TDNKVIEEKNELIRDLET-QIECLMSDQECVKRNR-EEEIEQLNEVIEKLQQELANIGQK 2369
            T N   +EK  L R+ +  Q E   ++++  + N  E+E+E ++   E L+++   + ++
Sbjct: 1897 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ 1956

Query: 2370 TSMNAHSLSEEADS-LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
                 H  S    S   H  D+ + ++ A         E+   ++  L +   ++NQ  Q
Sbjct: 1957 LMEMQHLRSTATPSPSPHAWDLQLLQQQACPM---VPREQFLQLQRQLLQAE-RINQHLQ 2012

Query: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2488
            E   L+         Q   E  V V  + + + + +L++V      K L  +   +  E+
Sbjct: 2013 E--ELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV------KRLLQEKVNQLKEQ 2064

Query: 2489 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
              K +  +   + L +E+    K LE+T+        Q+  + +  +L++KI +L  IV 
Sbjct: 2065 LCKNTKADAMVKDLYVENAQLLKALEVTE------QRQKTAEKKNYLLEEKIASLSNIVR 2118

Query: 2549 EKVAAALVS 2557
                A L S
Sbjct: 2119 NLTPAPLTS 2127



 Score =  148 bits (373), Expect = 1e-34
 Identities = 384/1953 (19%), Positives = 780/1953 (39%), Gaps = 306/1953 (15%)

Query: 1816 EEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA-ISETSSQLEHAKVT 1874
            EEG E SQ ++++     + +    EL L + + L      + +A ++   +++ H    
Sbjct: 316  EEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLER 375

Query: 1875 QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD----- 1929
              +++RE              +E+LR  L +  + +  +A E+      I+   +     
Sbjct: 376  VDQVVRE--------------KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRK 421

Query: 1930 -EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988
             ++   ER    K ++    EQ L  A  +  ELE E ++ + E   +  +      E  
Sbjct: 422  LDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENS 481

Query: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048
             +E +LL+  EKL     E +    K++ +L+  +     D++   + F  L++E+ T++
Sbjct: 482  RLENELLENAEKL----AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF-LQEERLTQM 536

Query: 2049 M-DLRQQNQALEKQLEKMRKFLDEQAIDR----------------------EHERDVFQQ 2085
              +  +Q + L+ Q+++++  L+E                           E E  +  +
Sbjct: 537  RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE 596

Query: 2086 EIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT----DKCSELLLSKEQLQRDIQE 2141
            E   L   ++     + + E   R++  L   L++K      +  E ++S ++ Q ++++
Sbjct: 597  ECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 656

Query: 2142 RNE-EIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPE-LSLEVQLQAERDAID 2199
            R+E E   LE ++ +L+  +         +++  H      + E   L+V+L+ E+  + 
Sbjct: 657  RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716

Query: 2200 RK---------EKEITNLEEQLEQFREELENK---NEEVQQLHMQLEIQKKESTTRLQEL 2247
             K         +  +T  +   E+ RE L++     E+V+ L  +LE   +E  T L E 
Sbjct: 717  EKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE- 775

Query: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEID-QLNEQVTKLQQ 2306
              ++ L K+++ K                  L  K  + +QE   +++ + N + ++++ 
Sbjct: 776  --KHTLEKEELRK-----------------ELLEKHQRELQEGREKMETECNRRTSQIEA 816

Query: 2307 QLKITTDNKVIEEKNELIRDLE----TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362
            Q + +   KV E     ++ LE     +++ L   Q   K   E E ++L +   + Q+ 
Sbjct: 817  QFQ-SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL 875

Query: 2363 LANIGQKTSMNAHSLSEEADSL----KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2418
            L    ++    +  L++E + L    K  L+ ++ E+  L Q +E         +++L +
Sbjct: 876  LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 935

Query: 2419 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2478
                  Q+ +   S KRE    E++      S  +A   L + + E +    E   K L 
Sbjct: 936  ------QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989

Query: 2479 NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2538
             +   K+  E        + T + +L+S              +IK+MQ Q      MLQ 
Sbjct: 990  MENIHKATCETADRERAEMSTEISRLQS--------------KIKEMQ-QATSPLSMLQS 1034

Query: 2539 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2598
                 Q I EE+V         L  +Q+  +  ++N  +    +R + Q + +    ++ 
Sbjct: 1035 ---GCQVIGEEEVE----GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE--NVKMA 1085

Query: 2599 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ--KLLEG---- 2652
            ++IS L  R+ +LE  +V    S  L++   E    N  E+ +  L+    K +EG    
Sbjct: 1086 TEISRLQQRLQKLEPGLV---MSSCLDEPATEFF-GNTAEQTEPFLQQNRTKQVEGVTRR 1141

Query: 2653 ---NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYK 2709
               ++ +  E     S     V +   ++  S      F+ELE     S  T+ E    K
Sbjct: 1142 HVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELE----NSEETRTESWELK 1197

Query: 2710 EKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET--------EVQES 2761
             +  +LQE+L++   +     +    +   ++  K+KL +LE+  E         E    
Sbjct: 1198 NQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSR 1257

Query: 2762 KKACMFEPLPI-------------KLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINL 2808
            +  C+ E L +             +L+  +    D   K+    +T   L K+       
Sbjct: 1258 ENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYD----- 1312

Query: 2809 QSECSSEEVTEIISQFTEKIEKMQE---------LHAAEILDME----------SRHISE 2849
            + +  +EE+  ++ +   KIEK+QE         L  A + ++E          ++ + E
Sbjct: 1313 EVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEE 1372

Query: 2850 TETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDW 2909
                 R  +  ++  K+E   L+   Q L   +   I                      W
Sbjct: 1373 CVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIA---------------------W 1411

Query: 2910 GQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGE 2969
              G   TH +   + ++   EE+ +      K  +      H   +  L L        E
Sbjct: 1412 LHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQ------HQATIAELEL--------E 1457

Query: 2970 DHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE-VYDSSQSHESFSDWRGELLL 3028
               +Q+++   L+ER   +  +   KD+++  + + E + +    Q   S    + ELL 
Sbjct: 1458 KTKLQELTRK-LKER---VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLR 1513

Query: 3029 ALQQVFLEERSVLLAAFRTELTALGTTDAV-----GLLNCLEQRIQEQGVEYQAAMECLQ 3083
               +   +E S+L    R E+T L   D++     G LN  ++ + ++    +     +Q
Sbjct: 1514 YESEKLQQENSIL----RNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1569

Query: 3084 KADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSM 3143
            K         ++ L  Q++  KI   + Q+ +  + EL + N  Q Q ++ E+   L+ M
Sbjct: 1570 KM--------VENLKKQISELKI---KNQQLDLENTELSQKN-SQNQEKLQELNQRLTEM 1617

Query: 3144 -----KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
                 K+      E+   EK     LK EL + K++  T + +    L E+   +++   
Sbjct: 1618 LCQKEKEPGNSALEEREQEKF---NLKEELERCKVQSSTLVSSLEAELSEV---KIQTHI 1671

Query: 3199 KTDEVHLLNDTLASEQKKSR--ELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN 3256
               E HLL D L   ++  R  +L    +K  + L  +E+  KE+ E L   L S   + 
Sbjct: 1672 VQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK-EALSEELNSCVDK- 1729

Query: 3257 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
            L  + LLE +   + + Q+  E Q     +QL   Q +   L+  +++  +++  M S L
Sbjct: 1730 LAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL 1789

Query: 3317 ---DRERE--------LHAQLQSSDGTGQSRPPLPS-----------------EDLLKEL 3348
                +E+E        LH QLQ++ G   + P + +                 + L+ E 
Sbjct: 1790 RVTQQEKEALKQEVMSLHKQLQNAGGKSWA-PEIATHPSGLHNQQKRLSWDKLDHLMNEE 1848

Query: 3349 QKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD-RQVHRKTLQTEQEANTEGQKKMHE 3407
            Q+ L +++ R+  ++  T+     S +  +Q+E +    H+K L      N   Q+K+  
Sbjct: 1849 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL-S 1907

Query: 3408 LQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP 3467
            L+ + +  Q++     ++V +++   Q L+ I  E +  + +++ K + + +  Q+L   
Sbjct: 1908 LKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK-KKQVKLDEQLMEMQHLRST 1966

Query: 3468 TTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQ 3527
             T S +       +LQQ+         + +L          N  L+   ++L+   S+  
Sbjct: 1967 ATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQ---EELENRTSETN 2023

Query: 3528 VLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTER 3587
              PQ   E  Q  T  +E  I V++ +  +   LQ+   Q  E+   +  +T   ++ + 
Sbjct: 2024 T-PQGNQE--QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ---LCKNTKADAMVKD 2077

Query: 3588 LLRQNAELTGHISQLTEEKNDLRNMVMKLEEQI 3620
            L  +NA+L   +    + +         LEE+I
Sbjct: 2078 LYVENAQLLKALEVTEQRQKTAEKKNYLLEEKI 2110



 Score =  145 bits (367), Expect = 6e-34
 Identities = 384/1975 (19%), Positives = 799/1975 (40%), Gaps = 353/1975 (17%)

Query: 213  NLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT 272
            N Q+  +  D ++   + LTE +  L+ +          +NS H +  A     K +I  
Sbjct: 321  NSQEILKALDFSLDGNINLTELTLALENELL------VTKNSIHQAALASF---KAEI-- 369

Query: 273  HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIE 332
             +  LE  D ++ + +K + D                +++ +K+++    E+ +    IE
Sbjct: 370  -RHLLERVDQVVREKEKLRSD----------------LDKAEKLKSLMASEVDDHHAAIE 412

Query: 333  ---ELNTKIIEEEKKT--LELKDKLTTA-DKLLGELQEQIVQKNQEIKNMKLELTNSKQK 386
               E N + ++EE K     LK++L    +++L +  +Q ++  QEI+  K E    + +
Sbjct: 413  RRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDR 472

Query: 387  ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDE------M 440
               S +E  +L     EL +   K +++E ++  ++++  +  L +   +LD       +
Sbjct: 473  LALSLKENSRLEN---ELLENAEKLAEYE-NLTNKLQRNLENVLAEKFGDLDPSSAEFFL 528

Query: 441  YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI 500
              +++ QM+ E  RQ     +++      E+++ L  Y        Q +++ + +   N 
Sbjct: 529  QEERLTQMRNEYERQCRVLQDQVD-----ELQSELEEY------RAQGRVLRLPLK--NS 575

Query: 501  KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIA---EQESK 557
              ++  +    ++ E GL  EE   L   +E    EL   + + Q  R       E E K
Sbjct: 576  PSEEVEANSGGIEPEHGLGSEECNPLNMSIE---AELVIEQMKEQHHRDICCLRLELEDK 632

Query: 558  LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE------KNAVL 611
            +    K L         +VS  ++++ ++ +HE E    + ++  L+ E      + AVL
Sbjct: 633  VRHYEKQLDET------VVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVL 686

Query: 612  DRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQ 671
                       E  + QL    EEE + L+E L ++H + ++         ++++ +GLQ
Sbjct: 687  KEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQ 746

Query: 672  NE---------MSQKIETMQFEKDNLITKQNQLILEISKLK----DLQQSLVNSKSEEMT 718
            +          ++Q++E  QF ++ L +   +  LE  +L+    +  Q  +    E+M 
Sbjct: 747  SSAWTEEKVRGLTQELE--QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKME 804

Query: 719  LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778
             + N    +IE   Q + +K T E+    LQ       +++K+ +   +E+ +Q E E  
Sbjct: 805  TECNRRTSQIEAQFQSDCQKVT-ERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKD 863

Query: 779  ILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ 838
             L  E    +++LK    + +E+    + + + +  +  +++ +  ++ E + L Q    
Sbjct: 864  ELTQECAEAQELLK--ETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLED 921

Query: 839  LNEEIEKQRNTFSFAEKNFEVNY-QEL--QEEYACLLKVKDDLEDSK-NKQELEY-KSKL 893
            L    E Q++  S      + ++ +EL  +EE  C     + L   +  + E+E+ + + 
Sbjct: 922  LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 981

Query: 894  KALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTE---LMEKLEVTKR 950
            + +++ L ++ I+  T +       E  T ++      + +++ T+    L    +V   
Sbjct: 982  EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1041

Query: 951  EKLELSQRLSDL--SEQLKQKHGEISF---------------LNEEVKSLKQEKEQ---- 989
            E++E    LS L   EQL +++G++                 +  E+  L+Q  ++    
Sbjct: 1042 EEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPG 1101

Query: 990  -VSLRC-------------RELEIIINHNRAENVQSCDTQ--VSSLLDGVVTMTSRGAEG 1033
             V   C              + E  +  NR + V+    +  +S L D  V         
Sbjct: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1161

Query: 1034 SVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL-------RA 1086
            SV +      EES+  VE     EN    EE++ E   L +  S  +E  +       RA
Sbjct: 1162 SVQRQEVKI-EESEASVEGFSELEN---SEETRTESWELKNQISQLQEQLMMLCADCDRA 1217

Query: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVY---STHVDQVRE---YMENEKD 1140
            ++  ++  L  +++VLK +   L    EA      L+Y   S   D ++E    ME   D
Sbjct: 1218 SEKKQD--LLFDVSVLKKKLKMLERIPEASP-KYKLLYEDVSRENDCLQEELRMMETRYD 1274

Query: 1141 KALCSLKE--ELIFAQEEKIKELQKIHQLELQTMKT-QETGDEGKPLHLLIGKLQKAVSE 1197
            +AL + KE    +F  ++++K+++++ +  L   K+  E   E + L++L+ +LQ  + +
Sbjct: 1275 EALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEK 1334

Query: 1198 ECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED-----PELQDYRYEVQDF 1252
                 +Q     L E     L+ E +       G+ +  N+      P ++   + +++ 
Sbjct: 1335 LQESVVQRCDCCLWEASLENLEIEPD-------GNILQLNQTLEECVPRVRSVHHVIEEC 1387

Query: 1253 -QENMHTLLNKVTEEYNKLLVLQTRLSKI-WGQQTDGMKLEFGEENLPKEETEFLSIHSQ 1310
             QEN +        E N  L+ + +  +I W   T    ++  +E    +    L  ++ 
Sbjct: 1388 KQENQYL-------EGNTQLLEKVKAHEIAWLHGT----IQTHQERPRVQNQVILEENTT 1436

Query: 1311 MTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLK-----ETEQNYEAEI 1365
            +   +D    H++ ++ L +LEKTKL+E  ++L+  ++ L +Q       E E+  +A +
Sbjct: 1437 LLGFQDKHFQHQATIAEL-ELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMM 1495

Query: 1366 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNID-------------G 1412
            H LQ     + +           V +   ++++     S ++  I              G
Sbjct: 1496 HDLQITCSEMQQ----------KVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLG 1545

Query: 1413 TIEFSGEFGVKEETNIVKLLEKQYQ---EQLEEEVAKVIVSMSIAFAQQTELSRISG--- 1466
            T+  S E  + ++T  VK      Q   E L+++++++ +       + TELS+ +    
Sbjct: 1546 TLNGSQE-EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604

Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF---QTFETVDVKFKEEFKPLSKELGE 1523
             K    + +    +CQ+E+   N     ++Q  F   +  E   V+       L  EL E
Sbjct: 1605 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE 1664

Query: 1524 HG-------------KEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS 1570
                           K+ L      H  P+  D    IS  +   +K    ++++ +E++
Sbjct: 1665 VKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELN 1724

Query: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630
             S +D   +  L E ++  M+QE  ++  EHQ A      +   Q+   +E  + L++ +
Sbjct: 1725 -SCVDKLAKSSLLEHRIATMKQE--QKSWEHQSA------SLKSQLVASQEKVQNLEDTV 1775

Query: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNE 1690
            + +N Q+++  S D      E+E +  E +   KQL  AG +    E+    +   N   
Sbjct: 1776 QNVNLQMSRMKS-DLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHN--- 1831

Query: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
                 +++     +LD         +++ E+  L + N RL                   
Sbjct: 1832 -----QQKRLSWDKLD--------HLMNEEQQLLWQENERL------------------- 1859

Query: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810
                             +++  ++AE +        H+R   E +     + +P++  ++
Sbjct: 1860 ----------------QTMVQNTKAELT--------HSR---EKVRQLESNLLPKHQKHL 1892

Query: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870
                T   TE  +  ++      E D   +E         Q+   + +  ++    +LE 
Sbjct: 1893 NPSGTMNPTEQEKLSLK-----RECDQFQKE---------QSPANRKVSQMNSLEQELE- 1937

Query: 1871 AKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA-----VELSKAEGVID 1925
                   L  E  ++KQ     +K  E+L E  H  S A    +     ++L + +    
Sbjct: 1938 ----TIHLENEGLKKKQ-----VKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPM 1988

Query: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ---IQEERELLSRQKEA 1982
               ++    +RQ+ +   I   L++EL   ++     +  Q+Q   + EER +   QK  
Sbjct: 1989 VPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLK 2048

Query: 1983 MKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ----VKALEIDVEEQ 2033
            +        ++LLQE    +KE+L    +A+ +  DL  +    +KALE+  + Q
Sbjct: 2049 L-------VKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQ 2096



 Score =  134 bits (338), Expect = 1e-30
 Identities = 342/1596 (21%), Positives = 684/1596 (42%), Gaps = 214/1596 (13%)

Query: 2207 NLEEQLEQFREE-LENKNEEVQQLHMQLE--IQKKESTTRLQELEQENKLFKDDMEKLGL 2263
            ++E  L+ ++EE +EN  E ++ L   L+  I   E T  L   E E  + K+ + +  L
Sbjct: 306  SVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLAL---ENELLVTKNSIHQAAL 362

Query: 2264 AIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK--VIEEKN 2321
            A     +   + +H+L  +  Q+++EKE     L ++  KL+  +    D+    IE +N
Sbjct: 363  A-----SFKAEIRHLL-ERVDQVVREKEKLRSDL-DKAEKLKSLMASEVDDHHAAIERRN 415

Query: 2322 EL-IRDLETQI-ECLMSDQECVKRNREEEIEQ-------LNEVIEKLQQELANIGQKTSM 2372
            E  +R L+ +  E + + +  +++ RE+ ++Q       L + IEK + E   I  + ++
Sbjct: 416  EYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLAL 475

Query: 2373 --------------NAHSLSEE---ADSLKHQLDVVIAEKLA----LEQQVETANEEMTF 2411
                          NA  L+E     + L+  L+ V+AEK         +     E +T 
Sbjct: 476  SLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQ 535

Query: 2412 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP-ENSVNVAIDHLSKD-KPELEVVL 2469
            M+N  +     +     EL S   E  +  ++  +P +NS +  ++  S   +PE  +  
Sbjct: 536  MRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGS 595

Query: 2470 TE--DALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ----CYKQIK 2523
             E      S+E +   +  +E     I  L    L+LE  V   + +L +    C K  +
Sbjct: 596  EECNPLNMSIEAELVIEQMKEQHHRDICCLR---LELEDKVRHYEKQLDETVVSCKKAQE 652

Query: 2524 DMQEQGQFETEMLQKKIVNLQ-KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPE 2582
            +M+++ + ET  L+K+I +L+ +I E +  AA++ +   EA   + +  +  Q +  E E
Sbjct: 653  NMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ-VKLEEE 711

Query: 2583 RTNIQNLNQLRED-EL----------------GSDISALTL-RISELESQVVEMHTSLIL 2624
            +T++Q   +L+ + EL                G   SA T  ++  L  ++ + H     
Sbjct: 712  KTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFH----- 766

Query: 2625 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2684
            +++   + EK+ LEKE+   EL       EK QRE ++ R   + E  + T+++     E
Sbjct: 767  QEQLTSLVEKHTLEKEELRKELL------EKHQRELQEGREKMETECNRRTSQI-----E 815

Query: 2685 SGFFNELEAL--RAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAE 2742
            + F ++ + +  R ES     E   Y+++ + LQE+   +E +    +KD  ++    AE
Sbjct: 816  AQFQSDCQKVTERCESALQSLE-GRYRQELKDLQEQQR-EEKSQWEFEKD--ELTQECAE 871

Query: 2743 AKEKLS-ILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLK----ISSSNQTPQI 2797
            A+E L   L++E  T +  +++  M E    +   S+  +    L+    + + ++T Q 
Sbjct: 872  AQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS 931

Query: 2798 LVKNAGIQINLQSECSSEEVTEIISQF-------TEKIEKMQELHAAE-------ILDME 2843
            L+ +  +++    +    E  E++ Q        ++++E+++  H  E       +L ME
Sbjct: 932  LLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME 991

Query: 2844 SRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSS 2903
            + H +  ET  RE       +  E   L++ I+ ++          +        E+   
Sbjct: 992  NIHKATCETADRERAE----MSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGD 1047

Query: 2904 DSGSDWGQGIYLTHSQGFDIASEGRG-EESESATDSFPKKIKGLLRAVHN--EGMQVLSL 2960
             + S   QG  L    G  + S  R  E++         +I  L + +     G+ + S 
Sbjct: 1048 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSC 1107

Query: 2961 TESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFS 3020
             + P ++   ++ +Q +EP+L++ +       + + +++ ++   + EV D   +     
Sbjct: 1108 LDEPATEFFGNTAEQ-TEPFLQQNRTKQVEGVTRRHVLSDLE---DDEVRDLGST----- 1158

Query: 3021 DWRGELLLALQQVFLEERSVLLAAF-RTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAM 3079
               G   +  Q+V +EE    +  F   E +    T++  L N + Q +QEQ +   A  
Sbjct: 1159 ---GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQ-LQEQLMMLCA-- 1212

Query: 3080 ECLQKADRRS-LLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3138
            +C + ++++  LL ++  L      +K+ +        P  +LL  ++ ++   + E   
Sbjct: 1213 DCDRASEKKQDLLFDVSVLK-----KKLKMLERIPEASPKYKLLYEDVSRENDCLQEELR 1267

Query: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
             + +  D A E  ++L++E   V  L+ EL + +   ET L         LE    EVK 
Sbjct: 1268 MMETRYDEALENNKELTAE---VFRLQDELKKMEEVTETFLS--------LEKSYDEVKI 1316

Query: 3199 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258
            + +E+++L   L  + +K +E    +++    L  +       LE+L+   +      LQ
Sbjct: 1317 ENEELNVLVLRLQGKIEKLQES--VVQRCDCCLWEAS------LENLEIEPDGNI---LQ 1365

Query: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3318
            LN       Q L E   ++ S   + +    E Q      Q+L   EKV+  E++     
Sbjct: 1366 LN-------QTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL---EKVKAHEIAW---- 1411

Query: 3319 ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL--EEKH----SRIVELLNETEKYKLD 3372
               LH  +Q    T Q RP + ++ +L+E    L  ++KH    + I EL  E EK KL 
Sbjct: 1412 ---LHGTIQ----THQERPRVQNQVILEENTTLLGFQDKHFQHQATIAEL--ELEKTKLQ 1462

Query: 3373 SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE 3432
             L  + +      V +K + +  E   E +  MH+LQ    ++Q+++E  R +  KL  E
Sbjct: 1463 ELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQE 1522

Query: 3433 GQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSD-RTRNWVLQQKIEGETK 3491
               L+      +   L  E+   + ++   N ++   W  T   +  N  +Q+ +E   K
Sbjct: 1523 NSILRN-----EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577

Query: 3492 ESNYAKL--IEMNGGGTGCNHELEMIRQKLQCVASKL-QVLPQKASE--RLQFETADDED 3546
            + +  K+   +++   T  + +    ++KLQ +  +L ++L QK  E      E  + E 
Sbjct: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637

Query: 3547 FIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEK 3606
            F  ++E ++   +Q   L      E S V   T        LL+   E    + +  +  
Sbjct: 1638 FN-LKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696

Query: 3607 NDLRNM--VMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIAS---EKEVWNREKLT 3661
            +  + +  V+   E++   ++  +   NS    L   + +E  IA+   E++ W  +  +
Sbjct: 1697 DFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSAS 1756

Query: 3662 LQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVT 3697
            L+  L  ++ +V  L+  ++N +L  +       VT
Sbjct: 1757 LKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVT 1792



 Score =  120 bits (302), Expect = 2e-26
 Identities = 288/1436 (20%), Positives = 594/1436 (41%), Gaps = 239/1436 (16%)

Query: 157  LEMMESELAGKQHEIE-ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ 215
            LE  + EL   + ++E E NR   ++   + ++  +  +  E+A++  +G   Q   +LQ
Sbjct: 789  LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848

Query: 216  -QARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI-LTH 273
             Q R EK +   E  ELT++  + Q   +     ETL+     +T+  L Q ++ +  T+
Sbjct: 849  EQQREEKSQWEFEKDELTQECAEAQELLK-----ETLKRE--KTTSLVLTQEREMLEKTY 901

Query: 274  QQQLE----EQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKET 329
            ++ L     E+  LL+D +  +     Q S L ++I         ++++S+K E++E+E 
Sbjct: 902  KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL--------ELKSSHKRELREREE 953

Query: 330  II-----------EELNTKIIEEEKKTLELKDKLT-----------TADKLLGELQEQIV 367
            ++           + L    +E +++  E+  KL            TAD+   E+  +I 
Sbjct: 954  VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1013

Query: 368  QKNQEIKNMK------------LELTNSKQKER-------QSSEEIKQLMGTVEELQKRN 408
            +   +IK M+             ++   ++ E        Q  E++ +  G V    +R 
Sbjct: 1014 RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA 1073

Query: 409  HKDSQFETDIVQRMEQETQRKLEQLRAEL----------DEMYGQQIVQMKQELIRQHMA 458
            H+ +  E   +       Q++L++L   L           E +G    Q +  L +    
Sbjct: 1074 HEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTK 1133

Query: 459  QMEEMKTRH-----KGEMENALRSYSNITVNEDQIKLMNVAIN-----------ELNIKL 502
            Q+E +  RH     + +    L S    +V   ++K+     +           E   + 
Sbjct: 1134 QVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTES 1193

Query: 503  QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH 562
             +  +Q  +L+E+L ++  +      + +DL+ ++S  +++++   + I E   K    +
Sbjct: 1194 WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER-IPEASPKYKLLY 1252

Query: 563  KSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622
            + +S   D   E +   E+R +  L++  E+T    +L+   K+   V +    S E   
Sbjct: 1253 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL-SLEKSY 1311

Query: 623  ERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQ 682
            + ++ +      EEL+ L   L+ +    IEKL++++     Q+ D    E S  +E ++
Sbjct: 1312 DEVKIE-----NEELNVLVLRLQGK----IEKLQESV----VQRCDCCLWEAS--LENLE 1356

Query: 683  FEKDNLITKQNQLILE-ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL 741
             E D  I + NQ + E + +++ +   +   K E   L+ N    E    + +  E   L
Sbjct: 1357 IEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLE----KVKAHEIAWL 1412

Query: 742  EQEVQELQLKTELLEKQMKEKENDL---QEKFAQLEAENSILKDEKKTLEDMLKIHTPVS 798
               +Q  Q +  +  + + E+   L   Q+K  Q +A  + L+ EK  L+++ +      
Sbjct: 1413 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTR-----K 1467

Query: 799  QEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFE 858
             +ER+  L  +K K   S  EKE E+    + DL+  C ++ +++E  R           
Sbjct: 1468 LKERVTIL--VKQKDVLSHGEKEEELKAMMH-DLQITCSEMQQKVELLR----------- 1513

Query: 859  VNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSS--- 915
               ++LQ+E + L      L +  +   L    KL  LN           TVK +++   
Sbjct: 1514 YESEKLQQENSILRNEITTLNEEDSISNL----KLGTLNGSQEEMWQKTETVKQENAAVQ 1569

Query: 916  -VFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974
             + +  K  ++E     + ++ + TEL +K    + +  EL+QRL+++  Q +++ G   
Sbjct: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG--- 1626

Query: 975  FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGS 1034
              N  ++  +QEK                N  E ++ C  Q S+L      ++S  AE S
Sbjct: 1627 --NSALEEREQEK---------------FNLKEELERCKVQSSTL------VSSLEAELS 1663

Query: 1035 VSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDK 1094
              K+     ++   +++D++        E+ KQ    L   P ++      ++  S N+K
Sbjct: 1664 EVKIQTHIVQQENHLLKDEL--------EKMKQ----LHRCPDLSDFQQKISSVLSYNEK 1711

Query: 1095 LQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ 1154
            L KE   L  E N         ++  S +    +  +++  ++ + ++  SLK +L+ A 
Sbjct: 1712 LLKEKEALSEELNSC-----VDKLAKSSLLEHRIATMKQEQKSWEHQS-ASLKSQLV-AS 1764

Query: 1155 EEKIKELQKIHQ---LELQTMKTQETGDEGKPLHLLIGKLQK-AVSEECSYFLQTLCSVL 1210
            +EK++ L+   Q   L++  MK+           L + + +K A+ +E     + L +  
Sbjct: 1765 QEKVQNLEDTVQNVNLQMSRMKSD----------LRVTQQEKEALKQEVMSLHKQLQNAG 1814

Query: 1211 GEYYTPALKCE---VNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY 1267
            G+ + P +      ++ + K  S D +    + E Q    E +  Q  +     ++T   
Sbjct: 1815 GKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSR 1874

Query: 1268 NKLLVLQTRLSKIWGQQ---------TDGMKLEFGEE--NLPKEETEFLSIHSQMTNLE- 1315
             K+  L++ L     +          T+  KL    E     KE++      SQM +LE 
Sbjct: 1875 EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQ 1934

Query: 1316 DIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQ----------QQLKETEQNYEAEI 1365
            +++  H       +  ++ KL+EQ+ E++ L S+            Q L++         
Sbjct: 1935 ELETIHLENEGLKK--KQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPRE 1992

Query: 1366 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425
              LQ + Q +    +   L  +     E+    T  P    ++ +  T+       V+++
Sbjct: 1993 QFLQLQRQLLQAERINQHLQEE----LENRTSETNTPQGNQEQLV--TVMEERMIEVEQK 2046

Query: 1426 TNIVKLLEKQYQEQLEEEVAK------VIVSMSIAFAQQTELSRISGGKENTASSK 1475
              +VK L ++   QL+E++ K      ++  + +  AQ  +   ++  ++ TA  K
Sbjct: 2047 LKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKK 2102



 Score =  116 bits (291), Expect = 4e-25
 Identities = 282/1386 (20%), Positives = 580/1386 (41%), Gaps = 245/1386 (17%)

Query: 7    QKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN--- 63
            ++K+     +L QF Q +  S  +  + ++++ RK    KH           +++CN   
Sbjct: 752  EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 811

Query: 64   ---EMYINS-----SQRVESTVIP-ESTIMRTLHSGEITSHEQGFSVELESEISTTADDC 114
               E    S     ++R ES +   E    + L   +    E+    E E +  T   +C
Sbjct: 812  SQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT--QEC 869

Query: 115  SSEVNGCSFVMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEE 173
            +         ++  K T+L L +E   ++ +Y E        HL  M  E      ++E+
Sbjct: 870  AEAQELLKETLKREKTTSLVLTQEREMLEKTYKE--------HLNSMVVERQQLLQDLED 921

Query: 174  LNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR-----------REKD 222
            L    E  +     + L+     +  +++R+ ++ Q  A+ Q A            +E+ 
Sbjct: 922  LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 981

Query: 223  ETMREFLEL---------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273
            E M + L +         T   ++ ++  +  +    ++    +++   +LQ+  Q++  
Sbjct: 982  EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1041

Query: 274  QQ--------QLEEQDHLLED------------YQKKKEDFTM--QISFLQEKIK----- 306
            ++         L++ + LLE+             Q  KE+  M  +IS LQ++++     
Sbjct: 1042 EEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPG 1101

Query: 307  -VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ 365
             V     D+          ++ E  +++  TK +E   +   L D      + LG     
Sbjct: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1161

Query: 366  IVQKNQEIKNMKLELTNSKQKERQSSEEIK----QLMGTVEELQKR-------------N 408
             VQ+ QE+K  + E +     E ++SEE +    +L   + +LQ++              
Sbjct: 1162 SVQR-QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1220

Query: 409  HKDSQFETDIVQR-----------------MEQETQRKLEQLRAELDEMYGQ--QIVQMK 449
             +D  F+  ++++                 + ++  R+ + L+ EL  M  +  + ++  
Sbjct: 1221 KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENN 1280

Query: 450  QELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509
            +EL  +     +E+K     +ME    ++ ++  + D++K+ N  +N L ++LQ    + 
Sbjct: 1281 KELTAEVFRLQDELK-----KMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQ---GKI 1332

Query: 510  EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569
            EKL+E + +   + C  +  LE+L  E       I +  QT+ E   ++   H     +E
Sbjct: 1333 EKLQESV-VQRCDCCLWEASLENLEIE---PDGNILQLNQTLEECVPRVRSVH---HVIE 1385

Query: 570  DLKAEIVSASESRKELELKHEAEVT-----------NYKIKLEMLEKEKNAVL---DRMA 615
            + K E      + + LE     E+              +++ +++ +E   +L   D+  
Sbjct: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF 1445

Query: 616  ESQE--AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ-----ID 668
            + Q   AELE  +T+L    +E   KLKE + I     + K KD L    K++     + 
Sbjct: 1446 QHQATIAELELEKTKL----QELTRKLKERVTI-----LVKQKDVLSHGEKEEELKAMMH 1496

Query: 669  GLQ---NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ 725
             LQ   +EM QK+E +++E + L  + + L  EI+ L + + S+ N K   +     E+ 
Sbjct: 1497 DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-EDSISNLKLGTLNGSQEEMW 1555

Query: 726  KEIEILRQE----EKEKGTLEQEVQELQLKTELLE---KQMKEKENDLQEKFAQL----- 773
            ++ E ++QE    +K    L++++ EL++K + L+    ++ +K +  QEK  +L     
Sbjct: 1556 QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLT 1615

Query: 774  --------EAENSILKD---EKKTLEDMLKIHTPVSQEERLIFLDSIKS--KSKDSVWEK 820
                    E  NS L++   EK  L++ L+    V     +  L++  S  K +  + ++
Sbjct: 1616 EMLCQKEKEPGNSALEEREQEKFNLKEELE-RCKVQSSTLVSSLEAELSEVKIQTHIVQQ 1674

Query: 821  EIEILIEENEDLKQ--QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKV-KDD 877
            E  +L +E E +KQ  +C  L++  +K  +  S+ EK  +      +E  +C+ K+ K  
Sbjct: 1675 ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1734

Query: 878  L-----------EDSKNKQELEYKSKLKALNEELH-----LQRINPTTVKMKSSVFDEDK 921
            L           + S   Q    KS+L A  E++      +Q +N    +MKS       
Sbjct: 1735 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSD------ 1788

Query: 922  TFVAETLEMGEVVEKDTTELMEKLEVT--KREKLELSQRLSDLSEQLKQKHGE--ISFLN 977
              +  T +  E ++++   L ++L+    K    E++   S L  Q K+   +     +N
Sbjct: 1789 --LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN 1846

Query: 978  EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV----SSLLDGVVTMTSRGAEG 1033
            EE + L QE E++    +  +  + H+R E V+  ++ +       L+   TM     E 
Sbjct: 1847 EEQQLLWQENERLQTMVQNTKAELTHSR-EKVRQLESNLLPKHQKHLNPSGTMNPTEQEK 1905

Query: 1034 -SVSKVNKSFGEES-----KIMVEDKVSFENMTV---GEESKQEQLILDHLPSVTKESSL 1084
             S+ +    F +E      K+   + +  E  T+    E  K++Q+ LD    + +   L
Sbjct: 1906 LSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDE--QLMEMQHL 1963

Query: 1085 RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQ-VREYMENE----- 1138
            R+T          +L +L+ +   +  + +  ++   L+ +  ++Q ++E +EN      
Sbjct: 1964 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2023

Query: 1139 ----KDKALCSLKEELIFAQEEKIKEL-----QKIHQLELQTMKTQETGDEGKPLHLLIG 1189
                  + L ++ EE +   E+K+K +     +K++QL+ Q  K  +     K L++   
Sbjct: 2024 TPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENA 2083

Query: 1190 KLQKAV 1195
            +L KA+
Sbjct: 2084 QLLKAL 2089



 Score =  113 bits (283), Expect = 3e-24
 Identities = 333/1711 (19%), Positives = 691/1711 (40%), Gaps = 223/1711 (13%)

Query: 103  LESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMES 162
            LE+E+   A+  +   N  + + R  +  N+L E+   +D S +E   Q+    L  M +
Sbjct: 483  LENELLENAEKLAEYENLTNKLQRNLE--NVLAEKFGDLDPSSAEFFLQEE--RLTQMRN 538

Query: 163  ELAGK----QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR 218
            E   +    Q +++EL  ELEE R       L         ++   G I           
Sbjct: 539  EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI----------- 587

Query: 219  REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLE 278
             E +  +      +E+   L +  +     E ++   H       L+ + ++  +++QL+
Sbjct: 588  -EPEHGLG-----SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLD 641

Query: 279  E--------QDHLLEDYQKKKEDFTMQISFLQEKIKVYE------MEQDKKVENSNKEEI 324
            E        Q+++ + ++ +      QIS L+ +I   +       E   +    ++EE 
Sbjct: 642  ETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK 701

Query: 325  QEKETIIEELNTKIIEEEK--KTLELKDKLTTADKLLGELQEQIVQK---NQEIKNMKLE 379
            ++ +  +EE  T + E+ +    +ELK +LT A       +E +       ++++ +  E
Sbjct: 702  KQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761

Query: 380  LTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE-TDIVQRMEQETQRKLEQLRAELD 438
            L    Q++  S  E   L    EEL+K   +  Q E  +  ++ME E  R+  Q+ A+  
Sbjct: 762  LEQFHQEQLTSLVEKHTL--EKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQ 819

Query: 439  E------MYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMN 492
                      +  +Q  +   RQ +  ++E +   K + E      +     E Q  L  
Sbjct: 820  SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ-ECAEAQELLKE 878

Query: 493  VAINELNIKL---QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
                E    L   Q+    ++  KE L  ++ E+  L + LEDL       R   +  + 
Sbjct: 879  TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-------RNVSETQQS 931

Query: 550  TIAEQESKLNEAHK-SLSTVEDLKAEIVS----ASESRKELELKHEAEVTNYKIKL---E 601
             +++Q  +L  +HK  L   E++  +  +    AS+  + LE++H+ E      KL   E
Sbjct: 932  LLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME 991

Query: 602  MLEKEKNAVLDRMAESQEAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
             + K      DR       E+ RL++++  +      LS L+   ++   I  E+++ + 
Sbjct: 992  NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQV---IGEEEVEGDG 1048

Query: 660  GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKD----LQQSLVNSK-- 713
             +   QQ + L  E    + ++Q   +  + +  ++  EIS+L+     L+  LV S   
Sbjct: 1049 ALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCL 1108

Query: 714  SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKE-----------K 762
             E  T       ++ E   Q+ + K    + V    + ++L + ++++           +
Sbjct: 1109 DEPATEFFGNTAEQTEPFLQQNRTKQV--EGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQ 1166

Query: 763  ENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ-EERLIFL----DSIKSKSKD-- 815
            E  ++E  A +E   S L++ ++T  +  ++   +SQ +E+L+ L    D    K +D  
Sbjct: 1167 EVKIEESEASVEG-FSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL 1225

Query: 816  ---SVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL----QEEY 868
               SV +K++++L E   +   +   L E++ ++ +      +  E  Y E     +E  
Sbjct: 1226 FDVSVLKKKLKML-ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELT 1284

Query: 869  ACLLKVKDDLEDSKNKQEL-----EYKSKLKALNEELH--LQRINPTTVKMKSSVFDEDK 921
            A + +++D+L+  +   E      +   ++K  NEEL+  + R+     K++ SV     
Sbjct: 1285 AEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCD 1344

Query: 922  TFVAET-------------LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQL-K 967
              + E              L++ + +E+    +     V +  K E +Q L   ++ L K
Sbjct: 1345 CCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQLLEK 1403

Query: 968  QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027
             K  EI++L+  +++  QE+ +V     + ++I+     EN      Q            
Sbjct: 1404 VKAHEIAWLHGTIQT-HQERPRV-----QNQVILE----ENTTLLGFQDKHFQHQATIAE 1453

Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRA- 1086
                +  + ++ +   E   I+V+ K   + ++ GE+ ++ + ++  L     E   +  
Sbjct: 1454 LELEKTKLQELTRKLKERVTILVKQK---DVLSHGEKEEELKAMMHDLQITCSEMQQKVE 1510

Query: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQ-------------VRE 1133
                E++KLQ+E ++L++E   L  +     + L  +  +  +              V++
Sbjct: 1511 LLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQK 1570

Query: 1134 YMENEKDKALCSLK----------EELIFAQEEKIKELQKIHQ--LELQTMKTQETGDEG 1181
             +EN K K +  LK           EL     +  ++LQ+++Q   E+   K +E G+  
Sbjct: 1571 MVENLK-KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629

Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
                       K   E C     TL S L E     +K + +   +EN   ++ ++E  +
Sbjct: 1630 LEEREQEKFNLKEELERCKVQSSTLVSSL-EAELSEVKIQTHIVQQEN---HLLKDELEK 1685

Query: 1242 LQDYRY--EVQDFQENMHTLLNKVTEEYN-KLLVLQTRLSKIWGQQTDGM-KLEFGEENL 1297
            ++      ++ DFQ+ + ++L+     YN KLL  +  LS+      D + K    E  +
Sbjct: 1686 MKQLHRCPDLSDFQQKISSVLS-----YNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740

Query: 1298 PKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKET 1357
               + E  S   Q  +L       KS+L + Q+ +   LE+ VQ +   +S ++  L+ T
Sbjct: 1741 ATMKQEQKSWEHQSASL-------KSQLVASQE-KVQNLEDTVQNVNLQMSRMKSDLRVT 1792

Query: 1358 EQNYEA---EIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTI 1414
            +Q  EA   E+  L K+LQ     +  P +      +     + +          +D  +
Sbjct: 1793 QQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSW-------DKLDHLM 1845

Query: 1415 EFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELS---RISGGKENT 1471
                +   +E   +  +++    E          +  ++    Q  L+    ++  ++  
Sbjct: 1846 NEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEK 1905

Query: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEI--L 1529
             S K+     Q+EQ   N  K+SQ     Q  ET+ ++  E  K    +L E   E+  L
Sbjct: 1906 LSLKRECDQFQKEQSPANR-KVSQMNSLEQELETIHLE-NEGLKKKQVKLDEQLMEMQHL 1963

Query: 1530 LSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLED 1589
             S + P   P + D       ++  +    +V +    ++    + A R     +E+LE+
Sbjct: 1964 RSTATPSPSPHAWDL------QLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELEN 2017

Query: 1590 MRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLV 1649
               E        +Q   ++ +  +   ++ +  +  LQE++ +L  QL + +  D     
Sbjct: 2018 RTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKAD----- 2072

Query: 1650 SERERVLLEELEALKQLSLAGREKLCCELRN 1680
            +  + + +E  + LK L +  + +   E +N
Sbjct: 2073 AMVKDLYVENAQLLKALEVTEQRQKTAEKKN 2103



 Score =  103 bits (257), Expect = 3e-21
 Identities = 246/1240 (19%), Positives = 509/1240 (41%), Gaps = 178/1240 (14%)

Query: 3    DEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQC 62
            D+ERQ+ +    A     +     +D +      +  R  S  K    A   L++ QS C
Sbjct: 977  DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGC 1036

Query: 63   NEM---------YINSSQRVESTVIPESTIMRTLHSGEITSHEQGF--SVELESEISTTA 111
              +          ++  Q+ E  +     ++ +L      +HEQ    +V++ +EIS   
Sbjct: 1037 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQR----AHEQAVKENVKMATEISRLQ 1092

Query: 112  DDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI 171
                    G        +P      E FG     +E   Q + T     + E   ++H +
Sbjct: 1093 QRLQKLEPGLVMSSCLDEPAT----EFFGNTAEQTEPFLQQNRTK----QVEGVTRRHVL 1144

Query: 172  EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLEL 231
             +L  E +E+R   G+ G   +Q  E  I++ +  +   +          +ET  E  EL
Sbjct: 1145 SDL--EDDEVR-DLGSTGTSSVQRQEVKIEESEASVEGFSE-----LENSEETRTESWEL 1196

Query: 232  TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKK 291
              Q  +LQ Q   L A     +        D+   K+++    + LE        Y+   
Sbjct: 1197 KNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL----KMLERIPEASPKYKLLY 1252

Query: 292  EDFTMQISFLQEKIKVYEMEQDKKVENSNKE------EIQEKETIIEELNTKIIEEEKKT 345
            ED + +   LQE++++ E   D+ +EN NKE       +Q++   +EE+    +  EK  
Sbjct: 1253 EDVSRENDCLQEELRMMETRYDEALEN-NKELTAEVFRLQDELKKMEEVTETFLSLEKSY 1311

Query: 346  LELKDKLTTADKL-------LGELQEQIVQK------NQEIKNMKLELTNSKQKERQSSE 392
             E+K +    + L       + +LQE +VQ+         ++N+++E   +  +  Q+ E
Sbjct: 1312 DEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLE 1371

Query: 393  E----IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRA-ELDEMYGQQIVQ 447
            E    ++ +   +EE ++ N           Q +E  TQ  LE+++A E+  ++G   +Q
Sbjct: 1372 ECVPRVRSVHHVIEECKQEN-----------QYLEGNTQL-LEKVKAHEIAWLHGT--IQ 1417

Query: 448  MKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
              QE  R     + E  T   G  +   +  + I     +++L    + EL  KL++  +
Sbjct: 1418 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIA----ELELEKTKLQELTRKLKERVT 1473

Query: 508  ----QKEKL-----KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558
                QK+ L     +EEL  ++ +      +++  VE L +  E++Q+    +  + + L
Sbjct: 1474 ILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL 1533

Query: 559  NE----AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYK-------IKLEMLEKEK 607
            NE    ++  L T+   + E+   +E+ K+     +  V N K       IK + L+ E 
Sbjct: 1534 NEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLEN 1593

Query: 608  NAVLDRMAESQEA--ELERLRTQLLFS------------HEEELSKLKEDLEIEHRINIE 653
              +  + +++QE   EL +  T++L               E+E   LKE+LE        
Sbjct: 1594 TELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELE-------- 1645

Query: 654  KLKDNLGIHYKQQIDGLQNEMSQ-KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS 712
                   +     +  L+ E+S+ KI+T   +++N + K      E+ K+K L +    S
Sbjct: 1646 ----RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD-----ELEKMKQLHRCPDLS 1696

Query: 713  KSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQ---MKEKENDLQEK 769
              ++    +  L    ++L+++E     L   V +L  K+ LLE +   MK+++   + +
Sbjct: 1697 DFQQKISSV--LSYNEKLLKEKEALSEELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQ 1753

Query: 770  FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEEN 829
             A L+++    +++ + LED +          + + L   + KS       ++ +  +E 
Sbjct: 1754 SASLKSQLVASQEKVQNLEDTV----------QNVNLQMSRMKS-------DLRVTQQEK 1796

Query: 830  EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEY 889
            E LKQ+ + L+++++         E     +    Q++     K+ D L + + +   + 
Sbjct: 1797 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKL-DHLMNEEQQLLWQE 1855

Query: 890  KSKLKAL--NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEV 947
              +L+ +  N +  L        +++S++  + +  +  +  M    E++   L  + + 
Sbjct: 1856 NERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNP-TEQEKLSLKRECDQ 1914

Query: 948  TKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN--- 1004
             ++E+   ++++S ++  L+Q+   I   NE +K  + + ++  +  + L      +   
Sbjct: 1915 FQKEQSPANRKVSQMN-SLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1973

Query: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064
             A ++Q    Q   ++     +  +       ++N+   EE    +E++ S  N   G  
Sbjct: 1974 HAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE----LENRTSETNTPQG-- 2027

Query: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124
              QEQL+     +V +E  +   Q     KL+    +L+ + N L+ Q+       ++V 
Sbjct: 2028 -NQEQLV-----TVMEERMIEVEQ-----KLKLVKRLLQEKVNQLKEQLCKNTKADAMVK 2076

Query: 1125 STHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI 1164
              +V+  +     E  +      E+  +  EEKI  L  I
Sbjct: 2077 DLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNI 2116



 Score = 83.6 bits (205), Expect = 4e-15
 Identities = 330/1692 (19%), Positives = 684/1692 (40%), Gaps = 233/1692 (13%)

Query: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR--ELEQALLVSADTFQKVEDRKHF 2176
            +E TD C   +LS E++   +Q+   + + L  RV   + ++AL++     + + + +HF
Sbjct: 31   EELTDLCH--MLSLEEVAPVLQQTLLQ-DNLLGRVHFDQFKEALILILS--RTLSNEEHF 85

Query: 2177 GAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE--ELENKNEEVQQLHMQL- 2233
                 +P+ SLE Q +  R       + +   +E +E+F E   +E  +EE +  H+   
Sbjct: 86   ----QEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAG 141

Query: 2234 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE 2293
            +  +   T R +E E E +L   + + L      S + S+  Q  +  K  ++ ++  + 
Sbjct: 142  DCSEHWKTQRSEEYEAEGQLRFWNPDDL----NASQSGSSPPQDWIEEKLQEVCEDLGIT 197

Query: 2294 ID-QLNEQ--VTKLQQQLKITTDNKVIEEK-NELIRDLETQIE----CLMSDQECVKRNR 2345
             D  LN +  V+  +Q      D +++EE  + L  D    +E     L  + + +  + 
Sbjct: 198  RDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSA 257

Query: 2346 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2405
                 QL   +    Q     G++T+ ++   S     +   LD  +    ++E+ ++T 
Sbjct: 258  STPYRQLKRHLS--MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGH-ASVERILDTW 314

Query: 2406 NEE-MTFMKNVLKETNFKMN---QLTQELFSLKRERESVEKIQSIPENSVNVA------- 2454
             EE +   + +LK  +F ++    LT+   +L+ E         + +NS++ A       
Sbjct: 315  QEEGIENSQEILKALDFSLDGNINLTELTLALENE-------LLVTKNSIHQAALASFKA 367

Query: 2455 --------IDHLSKDKPELEVVLTE-DALKSL---ENQTYFKSFEENGKGSIINLETRLL 2502
                    +D + ++K +L   L + + LKSL   E   +  + E   + ++  L+    
Sbjct: 368  EIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE--- 424

Query: 2503 QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE 2562
            + +  ++A   EL +  +QI     + + E E   +K    +  + +++A +L    +LE
Sbjct: 425  EYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLE 484

Query: 2563 -AVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTS 2621
              + E A+   + + ++++ +R N++N+   +  +L    +   L+   L     E    
Sbjct: 485  NELLENAEKLAEYENLTNKLQR-NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQ 543

Query: 2622 LILEKEQVEIAEKNVLE------------KEKKLLELQKLLEGNEKKQREKEKKRSPQDV 2669
              + ++QV+  +  + E            K     E++    G E +     ++ +P ++
Sbjct: 544  CRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNM 603

Query: 2670 EVLKTTTELFHSNEESGFFNELEALRAESVAT----KAELASYKEKAEKLQEELLVKETN 2725
             +     EL     +     ++  LR E        + +L       +K QE +  +  N
Sbjct: 604  SI---EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660

Query: 2726 MT-SLQKDLSQVRDHLAEAKEKLSILEK---EDETEVQESKKACM--FEPLPIKLSKSIA 2779
             T +L+K +S +++ +AE + + ++L++   E     +E KK      E     L + + 
Sbjct: 661  ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720

Query: 2780 SQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEI 2839
             Q +  LK   +        +  G    LQS   +EE    ++Q      ++++ H  ++
Sbjct: 721  LQHEMELKARLTQAQASFEREREG----LQSSAWTEEKVRGLTQ------ELEQFHQEQL 770

Query: 2840 LDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTRE 2899
              +  +H  E E L++E     Q   +E G  K   +C  ++  S I     SD  +  E
Sbjct: 771  TSLVEKHTLEKEELRKELLEKHQRELQE-GREKMETEC--NRRTSQIEAQFQSDCQKVTE 827

Query: 2900 ICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLS 2959
             C S   S  G+       +  D+  + R E+S+     F K        +  E  +   
Sbjct: 828  RCESALQSLEGR----YRQELKDLQEQQREEKSQW---EFEKD------ELTQECAEAQE 874

Query: 2960 LTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE-VYDSSQSHES 3018
            L +      +  S+    E  + E K Y   ++S+  ++ + QL ++ E + + S++ +S
Sbjct: 875  LLKETLKREKTTSLVLTQEREMLE-KTYKEHLNSM--VVERQQLLQDLEDLRNVSETQQS 931

Query: 3019 -FSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQA 3077
              SD   EL  + ++   E   VL  A  +E  A   +  +  L     + +++ +    
Sbjct: 932  LLSDQILELKSSHKRELREREEVLCQAGASEQLA---SQRLERLEMEHDQERQEMMSKLL 988

Query: 3078 AMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQ 3137
            AME + KA   +   E   +  +++  +  +K  Q++  P   +L+   Q    + +E  
Sbjct: 989  AMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSP-LSMLQSGCQVIGEEEVEGD 1047

Query: 3138 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3197
              LS ++ +  +L E+     + +     +  +  +++ T +    + L++LE   L + 
Sbjct: 1048 GALSLLQ-QGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP-GLVMS 1105

Query: 3198 DKTDE--VHLLNDTLAS-----EQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLE 3250
               DE       +T        +Q ++++++    +         + + +E+ DL  +  
Sbjct: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVL-----SDLEDDEVRDLGSTGT 1160

Query: 3251 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIR 3310
            S  QR          Q+  + ES+  +E    L +++ +  +   L+ Q+    E++ + 
Sbjct: 1161 SSVQR----------QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMM- 1209

Query: 3311 EMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEE--KHSRIVELLNETEK 3368
             + +  DR  E    L            L    +LK+  K LE   + S   +LL E   
Sbjct: 1210 -LCADCDRASEKKQDL------------LFDVSVLKKKLKMLERIPEASPKYKLLYEDVS 1256

Query: 3369 YKLDSLQTRQQMEKDRQ----VHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQ 3424
             + D LQ   +M + R      + K L  E     +  KKM E+      L++  +E + 
Sbjct: 1257 RENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKI 1316

Query: 3425 QVYKLDLEGQRLQGIMQEFQKQELER------EEKRESRRI----LYQNLNEPTTWSLTS 3474
            +  +L++   RLQG +++ Q+  ++R      E   E+  I        LN+     +  
Sbjct: 1317 ENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPR 1376

Query: 3475 DRTRNWVLQQ-KIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKA 3533
             R+ + V+++ K E +  E N   L ++        HE+  +   +Q    + +V  Q  
Sbjct: 1377 VRSVHHVIEECKQENQYLEGNTQLLEKVKA------HEIAWLHGTIQTHQERPRVQNQVI 1430

Query: 3534 SERLQFETADDEDFIWVQENIDEIILQ---LQKLTGQQGEEPSLV---SPSTSCGSLTER 3587
             E         +     Q  I E+ L+   LQ+LT +  E  +++       S G   E 
Sbjct: 1431 LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEE 1490

Query: 3588 L-------------LRQNAELTGHISQ-LTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNS 3633
            L             ++Q  EL  + S+ L +E + LRN +  L E+           D+ 
Sbjct: 1491 LKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE-----------DSI 1539

Query: 3634 SRFSLNGGANIEAIIASEKEVWNR------EKLTLQKSLKRAEAEVYKLK-----AELRN 3682
            S   L        +  S++E+W +      E   +QK ++  + ++ +LK      +L N
Sbjct: 1540 SNLKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLEN 1593

Query: 3683 DSLLQTLSPDSE 3694
              L Q  S + E
Sbjct: 1594 TELSQKNSQNQE 1605


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  157 bits (396), Expect = 3e-37
 Identities = 224/1105 (20%), Positives = 486/1105 (43%), Gaps = 167/1105 (15%)

Query: 157  LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
            ++  E EL   +   ++   EL+E+   +      QL E +  ++++    T+L A  ++
Sbjct: 854  MQAKEDELQKTKERQQKAENELKELEQKHS-----QLTEEKNLLQEQLQAETELYAEAEE 908

Query: 217  ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQ 276
             R          + L  + Q+L+    +++A             A+  +  QQ+L  ++Q
Sbjct: 909  MR----------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958

Query: 277  LEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE------------------------MEQ 312
            LEE++   +  Q +K     +I  L+++I V +                         E+
Sbjct: 959  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018

Query: 313  DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK--------------DKLTTADKL 358
            ++K +N  K +  + E++I EL  ++ +EEK   EL+              +++      
Sbjct: 1019 EEKAKNLTKLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077

Query: 359  LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418
            + EL+ Q+ +K +E++     L +   ++  + ++I++L G + +LQ+ +    +   + 
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE-DLDSERAARNK 1136

Query: 419  VQRMEQETQRKLEQLRAELDEMYG-------------QQIVQMKQEL---IRQHMAQMEE 462
             ++ +++   +LE L+ EL++                Q++  +K+ L    R H AQ++E
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196

Query: 463  MKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522
            M+ +H   +E        +T   +Q K     +++    L+  N+        LG   +E
Sbjct: 1197 MRQKHAQAVE-------ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249

Query: 523  KCALQRQLEDLVEELSFSREQIQRARQTIAEQESK-----------LNEAH-KSLSTVED 570
                +++LE  V+EL       +RAR  + ++  K           LNEA  K++   +D
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309

Query: 571  LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE--LER---- 624
            + A + S  +  +EL  +   +  N   KL  LE+E+N++ D++ E  EA+  LER    
Sbjct: 1310 V-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368

Query: 625  LRTQLLFSHE--EELSKLKEDLEIEHRINIEKLKDNLGIHYKQ------QIDGLQNEMSQ 676
            L  QL  S +  ++ +   E LE E +   +K  +NL   Y++      +++  +N + Q
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALE-EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427

Query: 677  KIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKS-------EEMTLQINELQKEI 728
            +++ +  + DN    Q QL+  +  K +   Q L   K+       E    +    +KE 
Sbjct: 1428 ELDDLVVDLDN----QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483

Query: 729  EILRQEEKEKGTLEQEVQELQLKTELLEKQMKE---KENDLQEKFAQLEAENSILK---D 782
            + L      +  LE + +EL+   ++L+ +M++    ++D+ +   +LE     L+   +
Sbjct: 1484 KALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 783  EKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED----LKQQCIQ 838
            E KT  + L+     +++ +L     +  ++    +E++++   E+NE+    L++Q  +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRL--EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600

Query: 839  LNEEIE---KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895
               E+E   KQR   + A+K  E + ++L+ +    +K +++      KQ  + ++++K 
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE----AIKQLRKLQAQMKD 1656

Query: 896  LNEELHLQRINPTTV-------KMKSSVFDEDKTFVAETLEMGEVVEK----DTTELMEK 944
               EL   R +   +       + K+   + D   + E L   E   K    +  EL E+
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716

Query: 945  L-------EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997
            L          + EK  L  R++ L E+L+++ G +  +++ V+   Q+ EQ+S      
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-----N 1771

Query: 998  EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057
            E+    + A+  +S   Q+    +  +       EG+V    KS  + +   +E K++  
Sbjct: 1772 ELATERSTAQKNESARQQLER-QNKELRSKLHEMEGAV----KSKFKSTIAALEAKIAQL 1826

Query: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117
               V +E++++Q     L    K+      Q  +  K+ ++    ++E+ + R++   ++
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE-QAEKGNARVKQLKRQ 1885

Query: 1118 ICLSLVYSTHVDQVREYMENEKDKA 1142
            +  +   S  ++  R  ++ E D+A
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEA 1910



 Score =  154 bits (388), Expect = 2e-36
 Identities = 232/1212 (19%), Positives = 531/1212 (43%), Gaps = 166/1212 (13%)

Query: 225  MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284
            ++  L++T Q +++Q +  +LQ ++  +    +    +L + +Q+      QL E+ +LL
Sbjct: 841  VKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN----ELKELEQK----HSQLTEEKNLL 892

Query: 285  EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
            ++              LQ + ++Y   ++ +V  + K+  QE E I+ E+  ++ EEE +
Sbjct: 893  QEQ-------------LQAETELYAEAEEMRVRLAAKK--QELEEILHEMEARLEEEEDR 937

Query: 345  TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
              +L+ +     + + +L+EQ+ ++    + ++LE   ++ K ++  +EI  +     +L
Sbjct: 938  GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997

Query: 405  QKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEE 462
             K      +  +D+   +  E+E  + L +L+ + + M  +  V++K+E   +   ++E+
Sbjct: 998  SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--EKSRQELEK 1055

Query: 463  MKTRHKGEMENALRSYSNITVNEDQIKL--------MNVAINELNIKLQDTNSQKEKLKE 514
            +K + +G+  +     +++     ++K+        +  A+  L+ ++   N+  +K++E
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1115

Query: 515  ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
                       L+  + DL E+L   R     AR    +Q+  L E  ++L T  +   +
Sbjct: 1116 -----------LEGHISDLQEDLDSER----AARNKAEKQKRDLGEELEALKTELE---D 1157

Query: 575  IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHE 634
             + ++ +++EL  K E EVT  K             LD    S EA+++ +R +    H 
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLK-----------KALDEETRSHEAQVQEMRQK----HA 1202

Query: 635  EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694
            + + +L E LE       ++ K NL  + KQ ++    +++ ++  +   K  +  K+ +
Sbjct: 1203 QAVEELTEQLE-----QFKRAKANLDKN-KQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256

Query: 695  LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE----ILRQEEKEKGTLEQEV----Q 746
            L  ++ +L+        +++ E+  ++++LQ E+E    +L + E +   L ++V     
Sbjct: 1257 LEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            +LQ   ELL+++ ++K N +  K  QLE E + L+D+   L++ ++    + +    + +
Sbjct: 1316 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNI 1371

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866
                SK K   +   +E L E                          +K F+   + L +
Sbjct: 1372 QLSDSKKKLQDFASTVEALEE-------------------------GKKRFQKEIENLTQ 1406

Query: 867  EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
            +Y       D LE +KN+ + E    L  L  +L  QR   + ++ K   FD+    +AE
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLDNQRQLVSNLEKKQRKFDQ---LLAE 1459

Query: 927  TLEMGE--VVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984
               +      E+D  E   + + TK   L L++ L +  E  ++       L  E++ L 
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETK--ALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517

Query: 985  QEKEQVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGV---------VTMTSRGAEG 1033
              K+ V     ELE      RA    ++   TQ+  L D +         + +  +  +G
Sbjct: 1518 SSKDDVGKNVHELE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574

Query: 1034 SVSK---VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLIL---DHLPSVTKESSLRAT 1087
               +         EE +  ++ ++      + +E KQ  L       L    K+  L+A 
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634

Query: 1088 QPSE-NDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
               +  ++  K+L  L+++  D + ++E  R     +++T  +  ++    E D  L  L
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD--LMQL 1692

Query: 1147 KEELIFAQE-EKIKELQK---IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202
            +E+L  A+   K  +L+K     +L           DE + L   I +L++ + EE    
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE---- 1748

Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNK 1262
             Q     + +    A +      ++  +    ++  +   Q    + ++ +  +H +   
Sbjct: 1749 -QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807

Query: 1263 VTEEY-NKLLVLQTRLSKIWGQ-QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
            V  ++ + +  L+ +++++  Q + +  + +   ++L +++ +   I  Q+ +   +   
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867

Query: 1321 HKSKL----SSLQDLEK--TKLEEQVQELESLISSLQQQLKETEQNYEA---EIHCLQKR 1371
            +K +     + ++ L++   + EE+ Q + +    LQ++L E  ++ EA   E++ L+ +
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927

Query: 1372 LQAVSESTVPPS 1383
            L+  +E++  PS
Sbjct: 1928 LRRGNETSFVPS 1939



 Score =  151 bits (382), Expect = 1e-35
 Identities = 236/1099 (21%), Positives = 484/1099 (44%), Gaps = 146/1099 (13%)

Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
            RL   V+ LL+     + Q E  +  + EL +   RQ++   E  + +++  +   E++ 
Sbjct: 836  RLFTKVKPLLQV----TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL 891

Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
             +EQL  E        + YA+ + +  R   +K +    LE+ L     RL+E E   QQ
Sbjct: 892  LQEQLQAE-------TELYAEAEEMRVRLAAKKQE----LEEILHEMEARLEEEEDRGQQ 940

Query: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQE---TEKLMKEKLEVQCQAEKVRDD------- 2018
            +Q ER+ +++Q          +E+QL +E    +KL  EK+  + + +K+ D+       
Sbjct: 941  LQAERKKMAQQML-------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993

Query: 2019 ---LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075
               L K+ K LE  + +  +   E E+EK   L  L+ +++++  +LE   K        
Sbjct: 994  NNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLK-------- 1044

Query: 2076 REHERDVFQQEIQKLEQQLK--VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
               + +  +QE++KL+++L+       + I++ Q  ++ +L   L +K +   EL  +  
Sbjct: 1045 ---KEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEE---ELQAALA 1097

Query: 2134 QLQRDIQERN---EEIEKLEFRVRELEQALLVSADTFQKVEDRK-----HFGAVEAKPEL 2185
            +L  +I ++N   ++I +LE  + +L++ L        K E +K        A++ + E 
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157

Query: 2186 SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ 2245
            +L+     +++   ++E+E+T L++ L++     E + +E++Q H Q       +   L 
Sbjct: 1158 TLD-STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-------AVEELT 1209

Query: 2246 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2305
            E  ++ K  K +++K    +++ +A    +  VL     Q  QE E +  +L  QV +LQ
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLEAQVQELQ 1265

Query: 2306 QQLKITTDNKVIEEKNELIRDLETQIEC---LMSDQECVKRNREEEIEQLNEVI---EKL 2359
               K +   +   E N+ +  L+ ++E    ++++ E       +++  L+  +   ++L
Sbjct: 1266 S--KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323

Query: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET 2419
             QE        S     L EE +SL+ QLD  +  K  LE+ + T N +++  K  L++ 
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383

Query: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLEN 2479
               +  L +     KR ++ +E +    E     A D L K K  L+  L +D +  L+N
Sbjct: 1384 ASTVEALEE---GKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQEL-DDLVVDLDN 1438

Query: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
            Q    S  E  +        +LL  E  +S+K            D +++ + E    + K
Sbjct: 1439 QRQLVSNLEKKQRKF----DQLLAEEKNISSK----------YADERDRAEAEAREKETK 1484

Query: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE----- 2594
             ++L + +EE    AL ++ +LE   +  K   ++   S +    N+  L + +      
Sbjct: 1485 ALSLARALEE----ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540

Query: 2595 -DELGSDISALTLRISELESQVVEMHTSLILEKEQVE-IAEKNVLEKEKKLLELQKLLE- 2651
             +E+ + +  L   +   E   + +  ++   K Q E   +    + E+K  +LQ+ L  
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600

Query: 2652 -----GNEKKQR---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKA 2703
                  +E+KQR      KK+   D++ L+   +      E     +L  L+A+    + 
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQMKDFQR 1659

Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK--EKLSILEKEDETEVQES 2761
            EL   +   +++       E    SL+ DL Q+++ LA A+   K + LEKE+       
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE------- 1712

Query: 2762 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS-EEVTEI 2820
                        L++ +AS   G  + +  ++  ++  + A ++  L+ E  + E +++ 
Sbjct: 1713 ------------LAEELASSLSG--RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758

Query: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880
            + + T++ E++    A E      ++ S  + L+R++      L E  G +K+  +   +
Sbjct: 1759 VRKATQQAEQLSNELATE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817

Query: 2881 KEGSSIPELAHSDAYQTRE 2899
               + I +L      + RE
Sbjct: 1818 ALEAKIAQLEEQVEQEARE 1836



 Score =  144 bits (362), Expect = 2e-33
 Identities = 234/1125 (20%), Positives = 480/1125 (42%), Gaps = 130/1125 (11%)

Query: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLR---QAHMRQMERQREDQEQLQEEIK---- 1631
            Q+   EE+++    EL +  +  Q+A   L+   Q H +  E +   QEQLQ E +    
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 1632 --RLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689
               +  +LA +   + E ++ E E  L EE +  +QL  A R+K+  ++ +         
Sbjct: 906  AEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQ-AERKKMAQQMLDL-------- 955

Query: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETI 1749
            E Q E EE   ++ +L++   +   + L +E   +   NN+L K           +EE I
Sbjct: 956  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK-------ERKLLEERI 1008

Query: 1750 GRHVLGILDRSSKSQSSASLIWR-----SEAEASVKSCVHEEHTRVTDESIPSY---SGS 1801
                  + +   K+++   L  +     SE E  +K    EE +R   E +        S
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK---EEKSRQELEKLKRKLEGDAS 1065

Query: 1802 DMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPE--NEELMLNISSRLQAAVEKLLE 1859
            D      ++ +++ E   +L+++      A   +D E   +   L     L+  +  L E
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 1860 AISETSSQLEHAKVTQTELMRESFRQKQEATESLKC---QEELRER-----------LHE 1905
             +    +    A+  + +L  E    K E  ++L     Q+ELR +           L E
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 1906 ESRAREQLAVEL-SKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964
            E+R+ E    E+  K    ++   ++   F+R           LE+E    +  L+ L  
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245

Query: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC------QAEKVRDD 2018
             +Q+++ +++ L  Q + ++++    E+   +  +K+ K + EV+       +AE     
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305

Query: 2019 LQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQALEKQL----------EKM 2065
            L K V +L   +++      E  ++K   +T+L  L ++  +L+ QL          E+ 
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365

Query: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125
               L+ Q  D + +   F   ++ LE+  K   RFQ   E+ T++ E+ A    +     
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTK 1422

Query: 2126 SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL 2185
            + L    + L  D+  + + +  LE + R+ +Q L    +   K  D +     EA+ + 
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 2186 SLEVQL-QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2244
            +  + L +A  +A++ KE E+    + L+   E+L +  ++V +   +LE  K+   T++
Sbjct: 1483 TKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541

Query: 2245 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2304
            +E++ + +  +D+++    A +++      +   L G+F + +Q ++   +Q  E+  +L
Sbjct: 1542 EEMKTQLEELEDELQ----ATEDAKLRLEVNMQALKGQFERDLQARD---EQNEEKRRQL 1594

Query: 2305 QQQLKITTDNKVIEEKNELI-----RDLETQIECLMSDQECVKRNREEEIEQLNEV---I 2356
            Q+QL         E K   +     + LE  ++ L    +   + REE I+QL ++   +
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654

Query: 2357 EKLQQELAN----------IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETAN 2406
            +  Q+EL +            ++    A SL  EAD ++ Q D+  AE+    +Q +   
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSL--EADLMQLQEDLAAAER--ARKQADLEK 1710

Query: 2407 EEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELE 2466
            EE+      L  +    N L  E   L+     +E+     + ++    D + K   + E
Sbjct: 1711 EELA---EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767

Query: 2467 VVLTEDALK---SLENQTYFKSFEENGKGSIINLETRLLQLE--------STVSAKDLEL 2515
             +  E A +   + +N++  +  E   K     L ++L ++E        ST++A + ++
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNK----ELRSKLHEMEGAVKSKFKSTIAALEAKI 1823

Query: 2516 TQCYKQIKDMQEQGQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQDN 2574
             Q  +Q++    + Q  T+ L++K   L++I ++ +    +  Q + +A +  A+  Q  
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883

Query: 2575 QTISSEPERTNIQNLN----QLREDELGSDISALTLRISELESQV 2615
            + +    E +   N N    Q   DE      A+   ++ L+S++
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score =  143 bits (360), Expect = 4e-33
 Identities = 248/1144 (21%), Positives = 503/1144 (43%), Gaps = 154/1144 (13%)

Query: 2394 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNV 2453
            E  A E +++   E     +N LKE   K +QLT+E   L+ + ++  ++ +  E  + V
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE-MRV 911

Query: 2454 AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG---SIINLETRLLQLESTVSA 2510
                L+  K ELE +L E   +  E +   +  +   K     +++LE +L + E+    
Sbjct: 912  ---RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968

Query: 2511 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA-VQEYAK 2569
              LE      +IK ++++     +    K+   +K++EE+++    +  + E   +   K
Sbjct: 969  LQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027

Query: 2570 FCQDNQTISSE------PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI 2623
                ++++ SE       E  + Q L +L+  +L  D S    +I++L++Q+ E+   L 
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKR-KLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 2624 LEKEQV---------EIAEKN-----VLEKEKKLLELQKLLEGNE--KKQREKEKKRSPQ 2667
             ++E++         EIA+KN     + E E  + +LQ+ L+     + + EK+K+   +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 2668 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2727
            ++E LKT               ELE    +S AT+ EL + +E+   + ++ L +ET   
Sbjct: 1147 ELEALKT---------------ELEDT-LDSTATQQELRAKREQEVTVLKKALDEETR-- 1188

Query: 2728 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA-CMFEPLPIKLSKSIASQTDGTL 2786
            S +  + ++R   A+A E+L+        ++++ K+A    +     L K  A       
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241

Query: 2787 KISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEKIEKMQ---ELHAAEILDM 2842
             +  + Q  +   K    Q+  LQS+CS  E     ++  +K+ K+Q   E     + + 
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQNEVESVTGMLNEA 1299

Query: 2843 ESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRS--KEGSSIPELAHSDAYQT 2897
            E + I    +  +L  +     +LL+EE      V   LR   +E +S+ +    +    
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359

Query: 2898 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR------AVH 2951
            + +    S  +    I L+ S+          E  E     F K+I+ L +      A +
Sbjct: 1360 QNLERHISTLN----IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415

Query: 2952 NEGMQVLSLTESPYSD---GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQR--- 3005
            ++  +  +  +    D     D+  Q VS    ++RK +   ++  K++ +K   +R   
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-FDQLLAEEKNISSKYADERDRA 1474

Query: 3006 EAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL----- 3060
            EAE  +      S +    E L A ++  LE  + +L A   +L +  + D VG      
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDLVS--SKDDVGKNVHEL 1530

Query: 3061 ---LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI--QALHAQMNGRKITLKREQESE 3115
                  LE +++E   + +   + LQ  +   L  E+  QAL  Q   R +  + EQ  E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE-RDLQARDEQNEE 1589

Query: 3116 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3175
            K          +Q Q Q+ E + EL   +       +Q +       +L+ +L   +L+ 
Sbjct: 1590 KR---------RQLQRQLHEYETELEDER-------KQRALAAAAKKKLEGDLKDLELQA 1633

Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
            ++ +K + + +K+L   + ++KD   E+         + + SR+  +A  KE  K  +S 
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELE--------DARASRDEIFATAKENEKKAKSL 1685

Query: 3236 ERDKEEL-EDLKFSLESQKQRNLQLNLLLEQQ------KQLLNESQQKIESQRMLYDAQL 3288
            E D  +L EDL  +  ++KQ +L+   L E+       +  L + ++++E++    + +L
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745

Query: 3289 SEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL 3348
             EEQG        +E+   R+R+ +   +   +L  +L +   T Q      +E   ++L
Sbjct: 1746 EEEQGN-------MEAMSDRVRKATQQAE---QLSNELATERSTAQK-----NESARQQL 1790

Query: 3349 QKQLEEKHSRIVELLNETE---KYKLDSLQTR-QQMEKDRQVHRKTLQTEQEANTEGQKK 3404
            ++Q +E  S++ E+    +   K  + +L+ +  Q+E+  +   +  Q   ++  +  KK
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850

Query: 3405 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
            + E+  +VED ++  E+ ++Q  K      R++ + ++ ++ E E +    +RR L + L
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907

Query: 3465 NEPT 3468
            +E T
Sbjct: 1908 DEAT 1911



 Score =  133 bits (334), Expect = 4e-30
 Identities = 280/1347 (20%), Positives = 551/1347 (40%), Gaps = 217/1347 (16%)

Query: 414  FETDIVQRMEQETQRKLEQLRAELDEMYG------------QQIVQMKQELIRQHMAQME 461
            F T ++  +E+E   K+  +      M              QQ+  MK  +I+++ A   
Sbjct: 770  FRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMK--VIQRNCAAYL 827

Query: 462  EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILE 521
            +++      +   ++    +T  E++++     + +   + Q   ++ ++L+++   + E
Sbjct: 828  KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887

Query: 522  EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED----LKAEIVS 577
            EK  LQ QL+   E  + + E   R      E E  L+E    L   ED    L+AE   
Sbjct: 888  EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947

Query: 578  ASESRKELELK-HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636
             ++   +LE +  E E    K++LE +             + EA++++L  ++L   ++ 
Sbjct: 948  MAQQMLDLEEQLEEEEAARQKLQLEKV-------------TAEAKIKKLEDEILVMDDQN 994

Query: 637  LSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696
                KE   +E RI+   L  NL    +++   L  ++  K E+M  E +  + K+ +  
Sbjct: 995  NKLSKERKLLEERIS--DLTTNLA-EEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSR 1050

Query: 697  LEISKLKDLQQSLVNSKSEEMT-LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELL 755
             E+ KLK   +   +   E++  LQ    + ++++ ++EE+ +  L +   E+  K   L
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110

Query: 756  EK--QMKEKENDLQEKF-AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
            +K  +++   +DLQE   ++  A N   K ++   E++  + T +        LDS  ++
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT-----LDSTATQ 1165

Query: 813  SK-DSVWEKEIEIL---IEEN--------EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
             +  +  E+E+ +L   ++E         ++++Q+  Q  EE+ +Q   F  A+ N + N
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225

Query: 861  YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
             Q L++E A L      L   + KQE+E+K K           ++     +++S   D +
Sbjct: 1226 KQTLEKENADLAGELRVL--GQAKQEVEHKKK-----------KLEAQVQELQSKCSDGE 1272

Query: 921  KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980
            +   AE  +    ++ +   +   L   + + ++L++ ++ LS QL+        L EE 
Sbjct: 1273 RA-RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEET 1328

Query: 981  KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1040
            +    +K  VS + R+LE        E   S   Q+   ++       +  E  +S +N 
Sbjct: 1329 R----QKLNVSTKLRQLE--------EERNSLQDQLDEEME-----AKQNLERHISTLNI 1371

Query: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100
               +  K + +   + E +  G++  Q++     + ++T++   +A   +  DKL+K  N
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKE-----IENLTQQYEEKA---AAYDKLEKTKN 1423

Query: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTH--VDQVREYMENEKDKALCSLKEELIFAQEEKI 1158
             L+ E +DL + ++ QR  +S +       DQ+    +N   K           A+E++ 
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483

Query: 1159 KELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218
            K L     LE + ++ +E  +          K+ KA  E                     
Sbjct: 1484 KALSLARALE-EALEAKEELER-------TNKMLKAEME--------------------- 1514

Query: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY----NKLLVLQ 1274
                   D  +S D + +N   EL+  +  ++   E M T L ++ +E     +  L L+
Sbjct: 1515 -------DLVSSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 1275 TRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKT 1334
              +  + GQ    ++    E+N  K       +H   T LED     + K  +L    K 
Sbjct: 1567 VNMQALKGQFERDLQAR-DEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKK 1620

Query: 1335 KLEEQVQELE----SLISSLQQQLKETEQNYEAEIHCLQKRLQ------------AVSES 1378
            KLE  +++LE    S I   ++ +K+  +  +A++   Q+ L+            A    
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENE 1679

Query: 1379 TVPPSLPVDSVVITE--SDAQRTMYPGSCVKKNIDGTI--EFSGEFGVKEETNIVKLLEK 1434
                SL  D + + E  + A+R        K+ +   +    SG   +++E   ++    
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739

Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494
            Q +E+LEEE                      G  E  A S +     QQ +   NE  L+
Sbjct: 1740 QLEEELEEE---------------------QGNME--AMSDRVRKATQQAEQLSNE--LA 1774

Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFS 1554
             ++   Q  E+   + + + K L  +L E    +           E+K   L    E  +
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834

Query: 1555 KDKTFIVRQSIHDEISVSSMDAS-RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHM 1613
            ++K    +       S+   D   ++++L   Q+ED R ++  QY+E  +       A +
Sbjct: 1835 REKQAATK-------SLKQKDKKLKEILL---QVEDER-KMAEQYKEQAEK----GNARV 1879

Query: 1614 RQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE-NLVSERERVLLEELEALKQLSLAGRE 1672
            +Q++RQ E+ E   EE +R+N   A R  +  E +  +E    +  E+ ALK     G E
Sbjct: 1880 KQLKRQLEEAE---EESQRIN---ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933

Query: 1673 KLCCELRNSSTQTQNGNENQGEVEEQT 1699
                  R S  +    N +  E E  T
Sbjct: 1934 TSFVPSRRSGGRRVIENADGSEEETDT 1960



 Score =  132 bits (331), Expect = 9e-30
 Identities = 239/1148 (20%), Positives = 501/1148 (43%), Gaps = 119/1148 (10%)

Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
            ++RQ+E M+A+    E +L +  E+  K + E++ + E+    L ++   L+  ++ +  
Sbjct: 847  VTRQEEEMQAK----EDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETE 901

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR----EHERDVFQQEIQKLE 2091
             + E E+ +    + L  + Q LE+ L +M   L+E+  DR    + ER    Q++  LE
Sbjct: 902  LYAEAEEMR----VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLE 956

Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151
            +QL+     +  +  Q  ++E++    K K  +  E+L+  +Q  +  +ER    + LE 
Sbjct: 957  EQLE-----EEEAARQKLQLEKVTAEAKIKKLE-DEILVMDDQNNKLSKER----KLLEE 1006

Query: 2152 RVRELEQALLVSADTFQKVEDRKHFGAVEAKPE---LSLEVQLQAERDAIDRKEKEITNL 2208
            R+ +L      + +  ++ E  K+   ++ K E     LEV+L+ E  +    EK    L
Sbjct: 1007 RISDL------TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060

Query: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2268
            E     F E++ +   ++ +L MQL  +++E    L  L+ E     + ++K    I+E 
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK----IREL 1116

Query: 2269 DAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLE 2328
            +   +  Q  L  + A   + ++ + D L E++  L+ +L+ T D+   +++    R+ E
Sbjct: 1117 EGHISDLQEDLDSERAARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQE 1175

Query: 2329 TQIECLMSDQEC---------VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2379
              +     D+E          +++   + +E+L E +E+ ++  AN+ +    N  +L +
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK----NKQTLEK 1231

Query: 2380 EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERES 2439
            E   L  +L V+   K  +E + +    ++  +++   +      +L  ++  L+ E ES
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291

Query: 2440 VEKIQSIPE-NSVNVAID--HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIIN 2496
            V  + +  E  ++ +A D   LS    + + +L E+  + L   T  +  EE        
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ 1351

Query: 2497 LETRL---LQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIV 2547
            L+  +     LE  +S  +++L+   K+++D        E+G+   +  QK+I NL +  
Sbjct: 1352 LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK---KRFQKEIENLTQQY 1408

Query: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2607
            EEK AA      +LE  +   +   D+  +  + +R  + NL + +             +
Sbjct: 1409 EEKAAA----YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR------------K 1452

Query: 2608 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ 2667
              +L ++   + +    E+++   AE    EKE K L L + LE   + + E E+     
Sbjct: 1453 FDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKML 1509

Query: 2668 DVEVLKTTTELFHSNEESG-FFNELE----ALRAESVATKAELASYKEKAEKLQEELLVK 2722
              E+     +L  S ++ G   +ELE    AL  +    K +L   +++ +  ++  L  
Sbjct: 1510 KAEM----EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 2723 ETNMTSL----QKDLSQVRDHLAEAKEKLSILEKEDETEVQ-ESKKACMFEPLPIKLS-- 2775
            E NM +L    ++DL    +   E + +L     E ETE++ E K+  +      KL   
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625

Query: 2776 -KSIASQTDGTLK--ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQ 2832
             K +  Q D  +K    +  Q  ++  +    Q  L+   +S +  EI +   E  +K +
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD--EIFATAKENEKKAK 1683

Query: 2833 ELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHS 2892
             L  A+++ ++   ++  E  +++  +  + L EE  +  +    L+ ++      +A  
Sbjct: 1684 SLE-ADLMQLQ-EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741

Query: 2893 DAYQTREICSSDSGSD-WGQGIYLTHSQGFDIASE-GRGEESESATDSFPKKIKGLLRAV 2950
            +     E  + ++ SD   +          ++A+E    +++ESA     ++ K L   +
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1801

Query: 2951 HNEGMQVLSLTESPYS--DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE 3008
            H     V S  +S  +  + +   +++  E    E++A   ++      + ++ LQ E E
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861

Query: 3009 VYDSSQSHESFSDWRGEL-LLALQQVFLEERSVLLAAFRTEL-----TALGTTDAVGL-L 3061
               + Q  E        +  L  Q    EE S  + A R +L      A  + +A+G  +
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921

Query: 3062 NCLEQRIQ 3069
            N L+ +++
Sbjct: 1922 NALKSKLR 1929



 Score =  131 bits (329), Expect = 1e-29
 Identities = 213/1071 (19%), Positives = 450/1071 (42%), Gaps = 162/1071 (15%)

Query: 2    EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
            E+E+R ++L+A + K+AQ      +   +  + +QK + +  +++  +    D  +    
Sbjct: 933  EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992

Query: 62   CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
             N       + +E  +   +T        E   +      + ES IS        E    
Sbjct: 993  QNNKLSKERKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE---- 1046

Query: 122  SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
                ++ +    L+ +  G    + EQ A D    +  ++ +LA K+ E++     L++ 
Sbjct: 1047 ---EKSRQELEKLKRKLEGDASDFHEQIA-DLQAQIAELKMQLAKKEEELQAALARLDD- 1101

Query: 182  RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
             +      L++++E E       G I+ L  +L   R  +++  ++  +L E+ + L+ +
Sbjct: 1102 EIAQKNNALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154

Query: 242  F----------QQLQASE-----TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLED 286
                       Q+L+A        L+ +    T +   Q ++    H Q +EE    LE 
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214

Query: 287  YQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----ETIIEELNTKIIEEE 342
            +++ K +       L+++    ++  + +V    K+E++ K    E  ++EL +K  + E
Sbjct: 1215 FKRAKANLDKNKQTLEKENA--DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272

Query: 343  KKTLELKDK-------LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIK 395
            +   EL DK       + +   +L E + + ++  +++ ++  +L ++++      EE +
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETR 1329

Query: 396  QLMGTVEELQKRNHKDSQFETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQELI 453
            Q +    +L++   + +  +  + + ME  Q  +R +  L  +L +       + K +  
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQDF 1383

Query: 454  RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNIKLQDTNSQKEKL 512
               +  +EE K R + E+EN  + Y       D++ K  N    EL+  + D ++Q++ +
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443

Query: 513  KEELGLILEEKCALQRQLEDLV-EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL 571
                   LE+K   QR+ + L+ EE + S +      +  AE   K     K+LS    L
Sbjct: 1444 SN-----LEKK---QRKFDQLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARAL 1492

Query: 572  KAEIVSASESRKELELKHEAEVTNYKIKLEM--LEKEKNAV------LDRMAESQEAELE 623
            +          + LE K E E TN  +K EM  L   K+ V      L++   + E ++E
Sbjct: 1493 E----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 624  RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK----------DNLGIHYKQQIDGLQNE 673
             ++TQL     E+  +  ED ++   +N++ LK          D      ++Q+    +E
Sbjct: 1543 EMKTQL--EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600

Query: 674  MSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE------EMTLQINELQKE 727
               ++E  + ++      + +L  ++  L+    S +  + E      ++  Q+ + Q+E
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660

Query: 728  IEILR-----------QEEKEKGTLEQEVQELQ---LKTELLEKQMKEKENDLQEKFAQL 773
            +E  R           + EK+  +LE ++ +LQ      E   KQ   ++ +L E+ A  
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720

Query: 774  EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK 833
             +  + L+DEK+ LE  +       +EE                 +  +E + +      
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEE-----------------QGNMEAMSDRVRKAT 1763

Query: 834  QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL 893
            QQ  QL+ E+  +R+T   A+KN E   Q+L+ +     +++  L + +   + ++KS +
Sbjct: 1764 QQAEQLSNELATERST---AQKN-ESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTI 1816

Query: 894  KAL-----------NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942
             AL            +E   ++    ++K K     E    V +  +M E  ++   +  
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876

Query: 943  EKLEVTKR---EKLELSQRLSDLSEQLKQKHGEISFLNE----EVKSLKQE 986
             +++  KR   E  E SQR++    +L+++  E +  NE    EV +LK +
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927



 Score =  122 bits (306), Expect = 7e-27
 Identities = 253/1214 (20%), Positives = 509/1214 (41%), Gaps = 161/1214 (13%)

Query: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143
            ++E+Q  E +L+     Q  +E++ +E+EQ  + L E+ +   E L ++ +L  + +E  
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910

Query: 2144 EEI----EKLEFRVRELEQALLVSADTFQKVE-DRKHFGAVEAKPELSLEVQLQAERDAI 2198
              +    ++LE  + E+E  L    D  Q+++ +RK      A+  L LE QL+ E  A 
Sbjct: 911  VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM----AQQMLDLEEQLEEEEAAR 966

Query: 2199 DRKEKEITNLEEQLEQFREEL---ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2255
             + + E    E ++++  +E+   +++N ++ +    LE +  + TT L E E++ K   
Sbjct: 967  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026

Query: 2256 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2315
                K    I E +    +++     +  ++ ++ E +    +EQ+  LQ Q        
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQ-------- 1077

Query: 2316 VIEEKNELIRDLETQIECL--MSDQECVKRNREEEIEQLNEVIEKLQQELAN---IGQKT 2370
            + E K +L +  E     L  + D+   K N  ++I +L   I  LQ++L +      K 
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137

Query: 2371 SMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE-EMTFMKNVLKETNFKMNQLTQE 2429
                  L EE ++LK +L+  + +  A +Q++    E E+T +K  L E         QE
Sbjct: 1138 EKQKRDLGEELEALKTELEDTL-DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196

Query: 2430 LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEEN 2489
            +   ++  ++VE++    E     A  +L K+K  LE                    +EN
Sbjct: 1197 M--RQKHAQAVEELTEQLEQFKR-AKANLDKNKQTLE--------------------KEN 1233

Query: 2490 GKGSIINLETRLL-QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
                 +  E R+L Q +  V  K  +L    ++++     G+     L  K+  LQ  VE
Sbjct: 1234 AD---LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290

Query: 2549 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRI 2608
                   V+ +  EA  +  K  +D  ++SS+     +Q+  +L ++E    ++  T ++
Sbjct: 1291 S------VTGMLNEAEGKAIKLAKDVASLSSQ-----LQDTQELLQEETRQKLNVST-KL 1338

Query: 2609 SELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE--GNEKKQREKEKKRSP 2666
             +LE +   +   L  E E  +  E+++     +L + +K L+   +  +  E+ KKR  
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398

Query: 2667 QDVEVLKTTTELFHSNEESGFFNELEALRAE----------SVATKAELASYKEKAEKLQ 2716
            +++E L    E     E++  +++LE  +             +  + +L S  EK ++  
Sbjct: 1399 KEIENLTQQYE-----EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453

Query: 2717 EELLVKETNMTSLQKDLSQVRDHL-AEAKEK----LSILEKEDETEVQESKKACMFEPLP 2771
            ++LL +E N++S   D    RD   AEA+EK    LS+    +E    + +     + L 
Sbjct: 1454 DQLLAEEKNISSKYAD---ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510

Query: 2772 IKLSKSIASQTD---GTLKISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEK 2827
             ++   ++S+ D      ++  S +  +  ++    Q+  L+ E  + E  ++  +   +
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 2828 IEKMQ---ELHAAEILDMESR---------HISETETLKREHYVAVQLLKEECGTLKAV- 2874
              K Q   +L A +  + E R         + +E E  +++  +A    K+  G LK + 
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1630

Query: 2875 IQCLRSKEG--SSIPELAHSDAYQT---REICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2929
            +Q   + +G   +I +L    A      RE+  + +  D    I+ T  +     +E + 
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD---EIFATAKE-----NEKKA 1682

Query: 2930 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2989
            +  E+      + +    RA     ++   L E   S     +  Q  +  LE R A   
Sbjct: 1683 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA--- 1739

Query: 2990 TISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTEL 3049
                          Q E E+ +   + E+ SD    +  A QQ   E+ S  LA  R+  
Sbjct: 1740 --------------QLEEELEEEQGNMEAMSD---RVRKATQQA--EQLSNELATERS-- 1778

Query: 3050 TALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLK 3109
            TA     A        Q+++ Q  E ++ +  ++ A +    S I AL A++      L+
Sbjct: 1779 TAQKNESA-------RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI----AQLE 1827

Query: 3110 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA 3169
             + E E   ++    +++QK  ++ E+ +++   +  A + +EQ       V +LK +L 
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887

Query: 3170 QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA 3229
            + + E +     + K  +EL+    E  +  + +    + L S+ ++  E  +   +   
Sbjct: 1888 EAEEESQRINANRRKLQRELD----EATESNEAMGREVNALKSKLRRGNETSFVPSRRSG 1943

Query: 3230 KLGRSEERDKEELE 3243
                 E  D  E E
Sbjct: 1944 GRRVIENADGSEEE 1957



 Score =  117 bits (292), Expect = 3e-25
 Identities = 242/1207 (20%), Positives = 495/1207 (41%), Gaps = 201/1207 (16%)

Query: 624  RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
            +++  L  + +EE  + KED        ++K K+      +Q+ +    E+ QK   +  
Sbjct: 840  KVKPLLQVTRQEEEMQAKED-------ELQKTKER-----QQKAENELKELEQKHSQLTE 887

Query: 684  EKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGT-L 741
            EK NL+ +Q Q   E+ ++ ++++  L   K E     + E+  E+E   +EE+++G  L
Sbjct: 888  EK-NLLQEQLQAETELYAEAEEMRVRLAAKKQE-----LEEILHEMEARLEEEEDRGQQL 941

Query: 742  EQEVQELQLKTELLEKQMKEKE-----------------NDLQEKFAQLEAENSILKDEK 784
            + E +++  +   LE+Q++E+E                   L+++   ++ +N+ L  E+
Sbjct: 942  QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001

Query: 785  KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844
            K LE+ +   T    EE     +  K K+K      E+E+ +++ E  +Q+  +L  ++E
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061

Query: 845  KQRNTFSFAEKNFEVNYQEL--------QEEYACLLKVKDDLEDSKN--KQELEYKSKLK 894
               + F     + +    EL        +E  A L ++ D++    N  K+  E +  + 
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121

Query: 895  ALNEELHLQRINPTTVKMKSSVFDED----KTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
             L E+L  +R      + +     E+    KT + +TL+     ++   +  +++ V K+
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181

Query: 951  EKLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENV 1009
               E ++      ++++QKH + +  L E+++  K+ K  +    + LE        EN 
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-------KENA 1234

Query: 1010 Q-SCDTQVSSLLDGVVTMTSRGAEGSVSKVNK--SFGEESKIMVEDKV--------SFEN 1058
              + + +V       V    +  E  V ++    S GE ++  + DKV        S   
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294

Query: 1059 MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRI 1118
            M    E K  +L  D     +  S L+ TQ    ++ +++LNV       LR Q+E +R 
Sbjct: 1295 MLNEAEGKAIKLAKD---VASLSSQLQDTQELLQEETRQKLNV----STKLR-QLEEERN 1346

Query: 1119 CLSLVYSTHVDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176
             L        DQ+ E ME ++  ++ + +L  +L     +  K+LQ           T E
Sbjct: 1347 SLQ-------DQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDF-------ASTVE 1388

Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYIS 1235
              +EGK       + QK +                E  T   + +  A DK E + + + 
Sbjct: 1389 ALEEGKK------RFQKEI----------------ENLTQQYEEKAAAYDKLEKTKNRLQ 1426

Query: 1236 ENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEE 1295
            +  D  + D      D Q  + + L K   ++++LL  +  +S  +  + D  + E  E+
Sbjct: 1427 QELDDLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 1296 -----NLPKEETEFLSIHSQM--------TNLEDIDVNHKSKLSSLQDLEKTK--LEEQV 1340
                 +L +   E L    ++          +ED+  +      ++ +LEK+K  LE Q+
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541

Query: 1341 QELESLISSLQQQLKETEQ-------NYEAEIHCLQKRLQAVSEST------VPPSLPVD 1387
            +E+++ +  L+ +L+ TE        N +A     ++ LQA  E        +   L   
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 1388 SVVITESDAQRTMYPGSCVKKNIDG---TIEFSGEFGVKEETNIVKLLE------KQYQE 1438
               + +   QR +   +  KK ++G    +E   +  +K     +K L       K +Q 
Sbjct: 1602 ETELEDERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGG----KENTASSKQAHAVCQQEQHYFNEMKLS 1494
            +LE+  A      + A   + +   +       +E+ A++++A      E+    E +L+
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE-ELA 1718

Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKEL-GEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553
                G    +    + +     L +EL  E G    +S+       +++     ++ E  
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 1554 SKDKTFIVRQ-----------SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ 1602
            +  K    RQ            +H+            +   E ++  + +++ ++ +E Q
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 1603 QATELLRQAHMR------QMERQREDQEQLQEE-------IKRLNRQLAQRSSIDNENLV 1649
             AT+ L+Q   +      Q+E +R+  EQ +E+       +K+L RQL + +  +++ + 
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EEAEEESQRIN 1897

Query: 1650 SERERVLLEELEALKQLSLAGRE--KLCCELRNSSTQTQNGNENQG---EVEEQTFKEKE 1704
            + R ++  E  EA +     GRE   L  +LR  +  +   +   G    +E     E+E
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1957

Query: 1705 LDRKPED 1711
             D +  D
Sbjct: 1958 TDTRDAD 1964



 Score = 82.8 bits (203), Expect = 6e-15
 Identities = 170/823 (20%), Positives = 351/823 (42%), Gaps = 127/823 (15%)

Query: 2931 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2990
            ++E+   +  ++++  L A   E  ++L   E+   + ED   Q  +E     RK     
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-----RKKMAQQ 951

Query: 2991 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL--------LALQQVFLEERSVLL 3042
            +  L++ + + +  R+    +   +         E+L        L+ ++  LEER   L
Sbjct: 952  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011

Query: 3043 AAFRTE-------LTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSE 3093
                 E       LT L       +++ LE R++++    Q   +  +K   D      +
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHE-SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 3094 IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3153
            I  L AQ+   K+ L +++E  + +   L+  I QK + + +++     ++   ++LQE 
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQED 1126

Query: 3154 LSSEKMV-------VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3206
            L SE+           +L  EL   K ELE TL +     +EL A R +      EV +L
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVL 1179

Query: 3207 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK---FSLESQKQRNLQLNLLL 3263
               L  E+ +S E Q  +++ + K  ++ E   E+LE  K    +L+  KQ   + N  L
Sbjct: 1180 KKAL-DEETRSHEAQ--VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236

Query: 3264 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3323
              + ++L +++Q++E ++   +AQ+ E Q +        + E+ R    +   D+  +L 
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSK------CSDGERAR----AELNDKVHKLQ 1286

Query: 3324 AQLQSSDGT---GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3380
             +++S  G     + +    ++D+   L  QL++      ELL E  + KL+     +Q+
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQ----ELLQEETRQKLNVSTKLRQL 1341

Query: 3381 EKDRQVHRKTLQTEQEAN--------------TEGQKKMHE--------------LQSKV 3412
            E++R   +  L  E EA               ++ +KK+ +               Q ++
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401

Query: 3413 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF------QKQELEREEKRESR--RILYQNL 3464
            E+L +Q EEK     KL+    RLQ  + +       Q+Q +   EK++ +  ++L +  
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461

Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELE----MIRQKLQ 3520
            N  + ++   DR       +  E ETK  + A+ +E          ELE    M++ +++
Sbjct: 1462 NISSKYADERDRAE----AEAREKETKALSLARALE---EALEAKEELERTNKMLKAEME 1514

Query: 3521 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ-QGEEPSLVSPST 3579
             + S    + +   E  + + A       ++  ++E+  QL++L  + Q  E + +    
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQLEELEDELQATEDAKLRLEV 1567

Query: 3580 SCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3639
            +  +L  +  R   +L     Q  E++  L+  + + E ++   R+  A    +++  L 
Sbjct: 1568 NMQALKGQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLE 1623

Query: 3640 GGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
            G    +  + ++  +  RE+    K L++ +A++   + EL +
Sbjct: 1624 GDLK-DLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELED 1663



 Score = 76.3 bits (186), Expect = 6e-13
 Identities = 119/577 (20%), Positives = 241/577 (41%), Gaps = 64/577 (11%)

Query: 3161 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK---KS 3217
            V   + E+   + EL+ T + Q K   EL+    +    T+E +LL + L +E +   ++
Sbjct: 847  VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906

Query: 3218 RELQWALEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3274
             E++  L  +K +L       E   EE ED    L++++++  Q  L LE+Q +    ++
Sbjct: 907  EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966

Query: 3275 QKIESQRMLYDAQLS---------EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3325
            QK++ +++  +A++          ++Q   L  +  L  E  RI ++++ L  E E    
Sbjct: 967  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE--RISDLTTNLAEEEEKAKN 1024

Query: 3326 LQSSDGTGQS---------RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3376
            L       +S         +    S   L++L+++LE   S   E + + +    +    
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084

Query: 3377 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE---- 3432
              + E++ Q     L  E        KK+ EL+  + DLQ  L+ +R    K + +    
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 3433 GQRLQGIMQEFQ--------KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3484
            G+ L+ +  E +        +QEL R ++ +   +L + L+E T       +       Q
Sbjct: 1145 GEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203

Query: 3485 KIEGETKESNYAKLIEMN---------GGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3535
             +E  T++    K  + N                 EL ++ Q  Q V  K + L  +  E
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263

Query: 3536 RLQFETADDEDF-IWVQENIDEIILQLQKLTGQQGE-EPSLVSPSTSCGSLTERL----- 3588
             LQ + +D E     + + + ++  +++ +TG   E E   +  +    SL+ +L     
Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322

Query: 3589 -----LRQNAELTGHISQLTEEKNDLRNMV---MKLEEQIRWYRQTGAGRDNSSRFSLNG 3640
                  RQ   ++  + QL EE+N L++ +   M+ ++ +  +  T   + + S+  L  
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382

Query: 3641 GANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLK 3677
             A+    +   K+ + +E   L +  +   A   KL+
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 92/466 (19%), Positives = 200/466 (42%), Gaps = 52/466 (11%)

Query: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240
            A +  L+  + +RL  K K     LL  T   E+ +++E +    KE+ +   +E ++ E
Sbjct: 824  AAYLKLRNWQWWRLFTKVKP----LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 879

Query: 3241 E----LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3296
            +    L + K  L+ Q Q   +L    E+ +  L   +Q++E      +A+L EE+ R  
Sbjct: 880  QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 939

Query: 3297 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL---------LKE 3347
            +LQ   +    ++ ++   L+ E     +LQ    T +++     +++         L +
Sbjct: 940  QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999

Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3407
             +K LEE+ S +   L E E+   +  + + + E         L+ E+++  E +K   +
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059

Query: 3408 LQSKVEDLQRQLEEKRQQVYKLDLE----GQRLQGIMQEFQKQELEREEKRESRRILYQN 3463
            L+    D   Q+ + + Q+ +L ++     + LQ  +     +  ++    +  R L  +
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119

Query: 3464 LNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ--- 3520
            +++               LQ+ ++ E    N A+  + + G      ELE ++ +L+   
Sbjct: 1120 ISD---------------LQEDLDSERAARNKAEKQKRDLG-----EELEALKTELEDTL 1159

Query: 3521 -CVASKLQVLPQKASERLQFETADDEDF----IWVQENIDEIILQLQKLTGQQGEEPSLV 3575
               A++ ++  ++  E    + A DE+       VQE   +    +++LT Q  +     
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ---FK 1216

Query: 3576 SPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3621
                +     + L ++NA+L G +  L + K ++ +   KLE Q++
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262



 Score = 70.5 bits (171), Expect = 3e-11
 Identities = 90/425 (21%), Positives = 184/425 (43%), Gaps = 61/425 (14%)

Query: 169  HEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ----------QAR 218
            HE+E+  R LE    T   E   QL+E E  ++  +    +L  N+Q          QAR
Sbjct: 1528 HELEKSKRALE----TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583

Query: 219  REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADL----LQAKQQILTHQ 274
             E++E  R   +L  Q  + + + +  +    L  +       DL    LQA   I   +
Sbjct: 1584 DEQNEEKRR--QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641

Query: 275  Q---QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331
            +   QL +    ++D+Q++ ED        +++I     E +KK ++   + +Q +E + 
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARAS----RDEIFATAKENEKKAKSLEADLMQLQEDLA 1697

Query: 332  EELNTKI---IEEEKKTLELKDKLTTADKLLGE---LQEQIVQKNQEIKNMKLELTNSKQ 385
                 +    +E+E+   EL   L+  + L  E   L+ +I Q  +E++  +  +     
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757

Query: 386  KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQI 445
            + R+++++ +QL   +   +    K+        +   Q+ +R+ ++LR++L EM G   
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGAVK 1809

Query: 446  VQMKQEL--IRQHMAQMEEMKTRHKGEMENALRSYSN--------ITVNEDQIKLMNVAI 495
             + K  +  +   +AQ+EE   +   E + A +S           +   ED+ K+     
Sbjct: 1810 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1869

Query: 496  NEL---NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE-------ELSFSREQIQ 545
             +    N +++    Q E+ +EE   I   +  LQR+L++  E       E++  + +++
Sbjct: 1870 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929

Query: 546  RARQT 550
            R  +T
Sbjct: 1930 RGNET 1934



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 91/505 (18%), Positives = 214/505 (42%), Gaps = 75/505 (14%)

Query: 4    EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63
            E++Q+K +   A+      + A    ++ ++ ++K+ K  S    +    +   +  + N
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506

Query: 64   EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
            +M       +E  V  +  + + +H  E+   ++    ++E E+ T  ++   E+     
Sbjct: 1507 KML---KAEMEDLVSSKDDVGKNVH--ELEKSKRALETQME-EMKTQLEELEDELQATED 1560

Query: 124  V-MRTGKPTNLLR---EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI-------E 172
              +R       L+   E +    D  +E+  +     L   E+EL  ++ +        +
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620

Query: 173  ELNRELEEMRVTYGT------EGLQQLQEFEAAIKQ-----------RDGIITQLTANLQ 215
            +L  +L+++ +   +      E ++QL++ +A +K            RD I      N +
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680

Query: 216  QARREKDETMR--EFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA--DLLQAKQQIL 271
            +A+  + + M+  E L   E+++K Q   ++ + +E L +S     A   +  + + +I 
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARK-QADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739

Query: 272  THQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331
              +++LEE+   +E    +    T Q   L       E+  ++     N+   Q+ E   
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSN-----ELATERSTAQKNESARQQLERQN 1794

Query: 332  EELNTKIIEEEKKTL-ELKDKLTTADKLLGELQEQIVQ--------------KNQEIKNM 376
            +EL +K+ E E     + K  +   +  + +L+EQ+ Q              K++++K +
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854

Query: 377  KLELTNSKQKERQSSEE-------IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
             L++ + ++   Q  E+       +KQL   +EE ++        E+  +    ++ QR+
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--------ESQRINANRRKLQRE 1906

Query: 430  LEQLRAELDEMYGQQIVQMKQELIR 454
            L++   E +E  G+++  +K +L R
Sbjct: 1907 LDE-ATESNEAMGREVNALKSKLRR 1930


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  157 bits (396), Expect = 3e-37
 Identities = 224/1105 (20%), Positives = 486/1105 (43%), Gaps = 167/1105 (15%)

Query: 157  LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
            ++  E EL   +   ++   EL+E+   +      QL E +  ++++    T+L A  ++
Sbjct: 861  MQAKEDELQKTKERQQKAENELKELEQKHS-----QLTEEKNLLQEQLQAETELYAEAEE 915

Query: 217  ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQ 276
             R          + L  + Q+L+    +++A             A+  +  QQ+L  ++Q
Sbjct: 916  MR----------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965

Query: 277  LEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE------------------------MEQ 312
            LEE++   +  Q +K     +I  L+++I V +                         E+
Sbjct: 966  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025

Query: 313  DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK--------------DKLTTADKL 358
            ++K +N  K +  + E++I EL  ++ +EEK   EL+              +++      
Sbjct: 1026 EEKAKNLTKLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084

Query: 359  LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418
            + EL+ Q+ +K +E++     L +   ++  + ++I++L G + +LQ+ +    +   + 
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE-DLDSERAARNK 1143

Query: 419  VQRMEQETQRKLEQLRAELDEMYG-------------QQIVQMKQEL---IRQHMAQMEE 462
             ++ +++   +LE L+ EL++                Q++  +K+ L    R H AQ++E
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203

Query: 463  MKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522
            M+ +H   +E        +T   +Q K     +++    L+  N+        LG   +E
Sbjct: 1204 MRQKHAQAVE-------ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256

Query: 523  KCALQRQLEDLVEELSFSREQIQRARQTIAEQESK-----------LNEAH-KSLSTVED 570
                +++LE  V+EL       +RAR  + ++  K           LNEA  K++   +D
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316

Query: 571  LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE--LER---- 624
            + A + S  +  +EL  +   +  N   KL  LE+E+N++ D++ E  EA+  LER    
Sbjct: 1317 V-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375

Query: 625  LRTQLLFSHE--EELSKLKEDLEIEHRINIEKLKDNLGIHYKQ------QIDGLQNEMSQ 676
            L  QL  S +  ++ +   E LE E +   +K  +NL   Y++      +++  +N + Q
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALE-EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434

Query: 677  KIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKS-------EEMTLQINELQKEI 728
            +++ +  + DN    Q QL+  +  K +   Q L   K+       E    +    +KE 
Sbjct: 1435 ELDDLVVDLDN----QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490

Query: 729  EILRQEEKEKGTLEQEVQELQLKTELLEKQMKE---KENDLQEKFAQLEAENSILK---D 782
            + L      +  LE + +EL+   ++L+ +M++    ++D+ +   +LE     L+   +
Sbjct: 1491 KALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 783  EKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED----LKQQCIQ 838
            E KT  + L+     +++ +L     +  ++    +E++++   E+NE+    L++Q  +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRL--EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607

Query: 839  LNEEIE---KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895
               E+E   KQR   + A+K  E + ++L+ +    +K +++      KQ  + ++++K 
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE----AIKQLRKLQAQMKD 1663

Query: 896  LNEELHLQRINPTTV-------KMKSSVFDEDKTFVAETLEMGEVVEK----DTTELMEK 944
               EL   R +   +       + K+   + D   + E L   E   K    +  EL E+
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723

Query: 945  L-------EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997
            L          + EK  L  R++ L E+L+++ G +  +++ V+   Q+ EQ+S      
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-----N 1778

Query: 998  EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057
            E+    + A+  +S   Q+    +  +       EG+V    KS  + +   +E K++  
Sbjct: 1779 ELATERSTAQKNESARQQLER-QNKELRSKLHEMEGAV----KSKFKSTIAALEAKIAQL 1833

Query: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117
               V +E++++Q     L    K+      Q  +  K+ ++    ++E+ + R++   ++
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE-QAEKGNARVKQLKRQ 1892

Query: 1118 ICLSLVYSTHVDQVREYMENEKDKA 1142
            +  +   S  ++  R  ++ E D+A
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEA 1917



 Score =  154 bits (388), Expect = 2e-36
 Identities = 232/1212 (19%), Positives = 531/1212 (43%), Gaps = 166/1212 (13%)

Query: 225  MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284
            ++  L++T Q +++Q +  +LQ ++  +    +    +L + +Q+      QL E+ +LL
Sbjct: 848  VKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN----ELKELEQK----HSQLTEEKNLL 899

Query: 285  EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
            ++              LQ + ++Y   ++ +V  + K+  QE E I+ E+  ++ EEE +
Sbjct: 900  QEQ-------------LQAETELYAEAEEMRVRLAAKK--QELEEILHEMEARLEEEEDR 944

Query: 345  TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
              +L+ +     + + +L+EQ+ ++    + ++LE   ++ K ++  +EI  +     +L
Sbjct: 945  GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004

Query: 405  QKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEE 462
             K      +  +D+   +  E+E  + L +L+ + + M  +  V++K+E   +   ++E+
Sbjct: 1005 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--EKSRQELEK 1062

Query: 463  MKTRHKGEMENALRSYSNITVNEDQIKL--------MNVAINELNIKLQDTNSQKEKLKE 514
            +K + +G+  +     +++     ++K+        +  A+  L+ ++   N+  +K++E
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122

Query: 515  ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
                       L+  + DL E+L   R     AR    +Q+  L E  ++L T  +   +
Sbjct: 1123 -----------LEGHISDLQEDLDSER----AARNKAEKQKRDLGEELEALKTELE---D 1164

Query: 575  IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHE 634
             + ++ +++EL  K E EVT  K             LD    S EA+++ +R +    H 
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLK-----------KALDEETRSHEAQVQEMRQK----HA 1209

Query: 635  EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694
            + + +L E LE       ++ K NL  + KQ ++    +++ ++  +   K  +  K+ +
Sbjct: 1210 QAVEELTEQLE-----QFKRAKANLDKN-KQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263

Query: 695  LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE----ILRQEEKEKGTLEQEV----Q 746
            L  ++ +L+        +++ E+  ++++LQ E+E    +L + E +   L ++V     
Sbjct: 1264 LEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
            +LQ   ELL+++ ++K N +  K  QLE E + L+D+   L++ ++    + +    + +
Sbjct: 1323 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNI 1378

Query: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866
                SK K   +   +E L E                          +K F+   + L +
Sbjct: 1379 QLSDSKKKLQDFASTVEALEE-------------------------GKKRFQKEIENLTQ 1413

Query: 867  EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
            +Y       D LE +KN+ + E    L  L  +L  QR   + ++ K   FD+    +AE
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLDNQRQLVSNLEKKQRKFDQ---LLAE 1466

Query: 927  TLEMGE--VVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984
               +      E+D  E   + + TK   L L++ L +  E  ++       L  E++ L 
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETK--ALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524

Query: 985  QEKEQVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGV---------VTMTSRGAEG 1033
              K+ V     ELE      RA    ++   TQ+  L D +         + +  +  +G
Sbjct: 1525 SSKDDVGKNVHELE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581

Query: 1034 SVSK---VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLIL---DHLPSVTKESSLRAT 1087
               +         EE +  ++ ++      + +E KQ  L       L    K+  L+A 
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641

Query: 1088 QPSE-NDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
               +  ++  K+L  L+++  D + ++E  R     +++T  +  ++    E D  L  L
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD--LMQL 1699

Query: 1147 KEELIFAQE-EKIKELQK---IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202
            +E+L  A+   K  +L+K     +L           DE + L   I +L++ + EE    
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE---- 1755

Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNK 1262
             Q     + +    A +      ++  +    ++  +   Q    + ++ +  +H +   
Sbjct: 1756 -QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814

Query: 1263 VTEEY-NKLLVLQTRLSKIWGQ-QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
            V  ++ + +  L+ +++++  Q + +  + +   ++L +++ +   I  Q+ +   +   
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874

Query: 1321 HKSKL----SSLQDLEK--TKLEEQVQELESLISSLQQQLKETEQNYEA---EIHCLQKR 1371
            +K +     + ++ L++   + EE+ Q + +    LQ++L E  ++ EA   E++ L+ +
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934

Query: 1372 LQAVSESTVPPS 1383
            L+  +E++  PS
Sbjct: 1935 LRRGNETSFVPS 1946



 Score =  151 bits (382), Expect = 1e-35
 Identities = 236/1099 (21%), Positives = 484/1099 (44%), Gaps = 146/1099 (13%)

Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
            RL   V+ LL+     + Q E  +  + EL +   RQ++   E  + +++  +   E++ 
Sbjct: 843  RLFTKVKPLLQV----TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL 898

Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
             +EQL  E        + YA+ + +  R   +K +    LE+ L     RL+E E   QQ
Sbjct: 899  LQEQLQAE-------TELYAEAEEMRVRLAAKKQE----LEEILHEMEARLEEEEDRGQQ 947

Query: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQE---TEKLMKEKLEVQCQAEKVRDD------- 2018
            +Q ER+ +++Q          +E+QL +E    +KL  EK+  + + +K+ D+       
Sbjct: 948  LQAERKKMAQQML-------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000

Query: 2019 ---LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075
               L K+ K LE  + +  +   E E+EK   L  L+ +++++  +LE   K        
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLK-------- 1051

Query: 2076 REHERDVFQQEIQKLEQQLK--VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
               + +  +QE++KL+++L+       + I++ Q  ++ +L   L +K +   EL  +  
Sbjct: 1052 ---KEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEE---ELQAALA 1104

Query: 2134 QLQRDIQERN---EEIEKLEFRVRELEQALLVSADTFQKVEDRK-----HFGAVEAKPEL 2185
            +L  +I ++N   ++I +LE  + +L++ L        K E +K        A++ + E 
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164

Query: 2186 SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ 2245
            +L+     +++   ++E+E+T L++ L++     E + +E++Q H Q       +   L 
Sbjct: 1165 TLD-STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-------AVEELT 1216

Query: 2246 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2305
            E  ++ K  K +++K    +++ +A    +  VL     Q  QE E +  +L  QV +LQ
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLEAQVQELQ 1272

Query: 2306 QQLKITTDNKVIEEKNELIRDLETQIEC---LMSDQECVKRNREEEIEQLNEVI---EKL 2359
               K +   +   E N+ +  L+ ++E    ++++ E       +++  L+  +   ++L
Sbjct: 1273 S--KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330

Query: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET 2419
             QE        S     L EE +SL+ QLD  +  K  LE+ + T N +++  K  L++ 
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390

Query: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLEN 2479
               +  L +     KR ++ +E +    E     A D L K K  L+  L +D +  L+N
Sbjct: 1391 ASTVEALEE---GKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQEL-DDLVVDLDN 1445

Query: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
            Q    S  E  +        +LL  E  +S+K            D +++ + E    + K
Sbjct: 1446 QRQLVSNLEKKQRKF----DQLLAEEKNISSK----------YADERDRAEAEAREKETK 1491

Query: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE----- 2594
             ++L + +EE    AL ++ +LE   +  K   ++   S +    N+  L + +      
Sbjct: 1492 ALSLARALEE----ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547

Query: 2595 -DELGSDISALTLRISELESQVVEMHTSLILEKEQVE-IAEKNVLEKEKKLLELQKLLE- 2651
             +E+ + +  L   +   E   + +  ++   K Q E   +    + E+K  +LQ+ L  
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607

Query: 2652 -----GNEKKQR---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKA 2703
                  +E+KQR      KK+   D++ L+   +      E     +L  L+A+    + 
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQMKDFQR 1666

Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK--EKLSILEKEDETEVQES 2761
            EL   +   +++       E    SL+ DL Q+++ LA A+   K + LEKE+       
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE------- 1719

Query: 2762 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS-EEVTEI 2820
                        L++ +AS   G  + +  ++  ++  + A ++  L+ E  + E +++ 
Sbjct: 1720 ------------LAEELASSLSG--RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765

Query: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880
            + + T++ E++    A E      ++ S  + L+R++      L E  G +K+  +   +
Sbjct: 1766 VRKATQQAEQLSNELATE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824

Query: 2881 KEGSSIPELAHSDAYQTRE 2899
               + I +L      + RE
Sbjct: 1825 ALEAKIAQLEEQVEQEARE 1843



 Score =  144 bits (362), Expect = 2e-33
 Identities = 234/1125 (20%), Positives = 480/1125 (42%), Gaps = 130/1125 (11%)

Query: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLR---QAHMRQMERQREDQEQLQEEIK---- 1631
            Q+   EE+++    EL +  +  Q+A   L+   Q H +  E +   QEQLQ E +    
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 1632 --RLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689
               +  +LA +   + E ++ E E  L EE +  +QL  A R+K+  ++ +         
Sbjct: 913  AEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQ-AERKKMAQQMLDL-------- 962

Query: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETI 1749
            E Q E EE   ++ +L++   +   + L +E   +   NN+L K           +EE I
Sbjct: 963  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK-------ERKLLEERI 1015

Query: 1750 GRHVLGILDRSSKSQSSASLIWR-----SEAEASVKSCVHEEHTRVTDESIPSY---SGS 1801
                  + +   K+++   L  +     SE E  +K    EE +R   E +        S
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK---EEKSRQELEKLKRKLEGDAS 1072

Query: 1802 DMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPE--NEELMLNISSRLQAAVEKLLE 1859
            D      ++ +++ E   +L+++      A   +D E   +   L     L+  +  L E
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 1860 AISETSSQLEHAKVTQTELMRESFRQKQEATESLKC---QEELRER-----------LHE 1905
             +    +    A+  + +L  E    K E  ++L     Q+ELR +           L E
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 1906 ESRAREQLAVEL-SKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964
            E+R+ E    E+  K    ++   ++   F+R           LE+E    +  L+ L  
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252

Query: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC------QAEKVRDD 2018
             +Q+++ +++ L  Q + ++++    E+   +  +K+ K + EV+       +AE     
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312

Query: 2019 LQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQALEKQL----------EKM 2065
            L K V +L   +++      E  ++K   +T+L  L ++  +L+ QL          E+ 
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125
               L+ Q  D + +   F   ++ LE+  K   RFQ   E+ T++ E+ A    +     
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTK 1429

Query: 2126 SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL 2185
            + L    + L  D+  + + +  LE + R+ +Q L    +   K  D +     EA+ + 
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 2186 SLEVQL-QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2244
            +  + L +A  +A++ KE E+    + L+   E+L +  ++V +   +LE  K+   T++
Sbjct: 1490 TKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548

Query: 2245 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2304
            +E++ + +  +D+++    A +++      +   L G+F + +Q ++   +Q  E+  +L
Sbjct: 1549 EEMKTQLEELEDELQ----ATEDAKLRLEVNMQALKGQFERDLQARD---EQNEEKRRQL 1601

Query: 2305 QQQLKITTDNKVIEEKNELI-----RDLETQIECLMSDQECVKRNREEEIEQLNEV---I 2356
            Q+QL         E K   +     + LE  ++ L    +   + REE I+QL ++   +
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661

Query: 2357 EKLQQELAN----------IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETAN 2406
            +  Q+EL +            ++    A SL  EAD ++ Q D+  AE+    +Q +   
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSL--EADLMQLQEDLAAAER--ARKQADLEK 1717

Query: 2407 EEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELE 2466
            EE+      L  +    N L  E   L+     +E+     + ++    D + K   + E
Sbjct: 1718 EELA---EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774

Query: 2467 VVLTEDALK---SLENQTYFKSFEENGKGSIINLETRLLQLE--------STVSAKDLEL 2515
             +  E A +   + +N++  +  E   K     L ++L ++E        ST++A + ++
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNK----ELRSKLHEMEGAVKSKFKSTIAALEAKI 1830

Query: 2516 TQCYKQIKDMQEQGQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQDN 2574
             Q  +Q++    + Q  T+ L++K   L++I ++ +    +  Q + +A +  A+  Q  
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890

Query: 2575 QTISSEPERTNIQNLN----QLREDELGSDISALTLRISELESQV 2615
            + +    E +   N N    Q   DE      A+   ++ L+S++
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score =  143 bits (360), Expect = 4e-33
 Identities = 248/1144 (21%), Positives = 503/1144 (43%), Gaps = 154/1144 (13%)

Query: 2394 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNV 2453
            E  A E +++   E     +N LKE   K +QLT+E   L+ + ++  ++ +  E  + V
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE-MRV 918

Query: 2454 AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG---SIINLETRLLQLESTVSA 2510
                L+  K ELE +L E   +  E +   +  +   K     +++LE +L + E+    
Sbjct: 919  ---RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

Query: 2511 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA-VQEYAK 2569
              LE      +IK ++++     +    K+   +K++EE+++    +  + E   +   K
Sbjct: 976  LQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034

Query: 2570 FCQDNQTISSE------PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI 2623
                ++++ SE       E  + Q L +L+  +L  D S    +I++L++Q+ E+   L 
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKR-KLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 2624 LEKEQV---------EIAEKN-----VLEKEKKLLELQKLLEGNE--KKQREKEKKRSPQ 2667
             ++E++         EIA+KN     + E E  + +LQ+ L+     + + EK+K+   +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 2668 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2727
            ++E LKT               ELE    +S AT+ EL + +E+   + ++ L +ET   
Sbjct: 1154 ELEALKT---------------ELEDT-LDSTATQQELRAKREQEVTVLKKALDEETR-- 1195

Query: 2728 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA-CMFEPLPIKLSKSIASQTDGTL 2786
            S +  + ++R   A+A E+L+        ++++ K+A    +     L K  A       
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248

Query: 2787 KISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEKIEKMQ---ELHAAEILDM 2842
             +  + Q  +   K    Q+  LQS+CS  E     ++  +K+ K+Q   E     + + 
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQNEVESVTGMLNEA 1306

Query: 2843 ESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRS--KEGSSIPELAHSDAYQT 2897
            E + I    +  +L  +     +LL+EE      V   LR   +E +S+ +    +    
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366

Query: 2898 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR------AVH 2951
            + +    S  +    I L+ S+          E  E     F K+I+ L +      A +
Sbjct: 1367 QNLERHISTLN----IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422

Query: 2952 NEGMQVLSLTESPYSD---GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQR--- 3005
            ++  +  +  +    D     D+  Q VS    ++RK +   ++  K++ +K   +R   
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-FDQLLAEEKNISSKYADERDRA 1481

Query: 3006 EAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL----- 3060
            EAE  +      S +    E L A ++  LE  + +L A   +L +  + D VG      
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDLVS--SKDDVGKNVHEL 1537

Query: 3061 ---LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI--QALHAQMNGRKITLKREQESE 3115
                  LE +++E   + +   + LQ  +   L  E+  QAL  Q   R +  + EQ  E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE-RDLQARDEQNEE 1596

Query: 3116 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3175
            K          +Q Q Q+ E + EL   +       +Q +       +L+ +L   +L+ 
Sbjct: 1597 KR---------RQLQRQLHEYETELEDER-------KQRALAAAAKKKLEGDLKDLELQA 1640

Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
            ++ +K + + +K+L   + ++KD   E+         + + SR+  +A  KE  K  +S 
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELE--------DARASRDEIFATAKENEKKAKSL 1692

Query: 3236 ERDKEEL-EDLKFSLESQKQRNLQLNLLLEQQ------KQLLNESQQKIESQRMLYDAQL 3288
            E D  +L EDL  +  ++KQ +L+   L E+       +  L + ++++E++    + +L
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752

Query: 3289 SEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL 3348
             EEQG        +E+   R+R+ +   +   +L  +L +   T Q      +E   ++L
Sbjct: 1753 EEEQGN-------MEAMSDRVRKATQQAE---QLSNELATERSTAQK-----NESARQQL 1797

Query: 3349 QKQLEEKHSRIVELLNETE---KYKLDSLQTR-QQMEKDRQVHRKTLQTEQEANTEGQKK 3404
            ++Q +E  S++ E+    +   K  + +L+ +  Q+E+  +   +  Q   ++  +  KK
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857

Query: 3405 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
            + E+  +VED ++  E+ ++Q  K      R++ + ++ ++ E E +    +RR L + L
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914

Query: 3465 NEPT 3468
            +E T
Sbjct: 1915 DEAT 1918



 Score =  133 bits (334), Expect = 4e-30
 Identities = 280/1347 (20%), Positives = 551/1347 (40%), Gaps = 217/1347 (16%)

Query: 414  FETDIVQRMEQETQRKLEQLRAELDEMYG------------QQIVQMKQELIRQHMAQME 461
            F T ++  +E+E   K+  +      M              QQ+  MK  +I+++ A   
Sbjct: 777  FRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMK--VIQRNCAAYL 834

Query: 462  EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILE 521
            +++      +   ++    +T  E++++     + +   + Q   ++ ++L+++   + E
Sbjct: 835  KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894

Query: 522  EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED----LKAEIVS 577
            EK  LQ QL+   E  + + E   R      E E  L+E    L   ED    L+AE   
Sbjct: 895  EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954

Query: 578  ASESRKELELK-HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636
             ++   +LE +  E E    K++LE +             + EA++++L  ++L   ++ 
Sbjct: 955  MAQQMLDLEEQLEEEEAARQKLQLEKV-------------TAEAKIKKLEDEILVMDDQN 1001

Query: 637  LSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696
                KE   +E RI+   L  NL    +++   L  ++  K E+M  E +  + K+ +  
Sbjct: 1002 NKLSKERKLLEERIS--DLTTNLA-EEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSR 1057

Query: 697  LEISKLKDLQQSLVNSKSEEMT-LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELL 755
             E+ KLK   +   +   E++  LQ    + ++++ ++EE+ +  L +   E+  K   L
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117

Query: 756  EK--QMKEKENDLQEKF-AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
            +K  +++   +DLQE   ++  A N   K ++   E++  + T +        LDS  ++
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT-----LDSTATQ 1172

Query: 813  SK-DSVWEKEIEIL---IEEN--------EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
             +  +  E+E+ +L   ++E         ++++Q+  Q  EE+ +Q   F  A+ N + N
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232

Query: 861  YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
             Q L++E A L      L   + KQE+E+K K           ++     +++S   D +
Sbjct: 1233 KQTLEKENADLAGELRVL--GQAKQEVEHKKK-----------KLEAQVQELQSKCSDGE 1279

Query: 921  KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980
            +   AE  +    ++ +   +   L   + + ++L++ ++ LS QL+        L EE 
Sbjct: 1280 RA-RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEET 1335

Query: 981  KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1040
            +    +K  VS + R+LE        E   S   Q+   ++       +  E  +S +N 
Sbjct: 1336 R----QKLNVSTKLRQLE--------EERNSLQDQLDEEME-----AKQNLERHISTLNI 1378

Query: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100
               +  K + +   + E +  G++  Q++     + ++T++   +A   +  DKL+K  N
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKE-----IENLTQQYEEKA---AAYDKLEKTKN 1430

Query: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTH--VDQVREYMENEKDKALCSLKEELIFAQEEKI 1158
             L+ E +DL + ++ QR  +S +       DQ+    +N   K           A+E++ 
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490

Query: 1159 KELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218
            K L     LE + ++ +E  +          K+ KA  E                     
Sbjct: 1491 KALSLARALE-EALEAKEELER-------TNKMLKAEME--------------------- 1521

Query: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY----NKLLVLQ 1274
                   D  +S D + +N   EL+  +  ++   E M T L ++ +E     +  L L+
Sbjct: 1522 -------DLVSSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 1275 TRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKT 1334
              +  + GQ    ++    E+N  K       +H   T LED     + K  +L    K 
Sbjct: 1574 VNMQALKGQFERDLQAR-DEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKK 1627

Query: 1335 KLEEQVQELE----SLISSLQQQLKETEQNYEAEIHCLQKRLQ------------AVSES 1378
            KLE  +++LE    S I   ++ +K+  +  +A++   Q+ L+            A    
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENE 1686

Query: 1379 TVPPSLPVDSVVITE--SDAQRTMYPGSCVKKNIDGTI--EFSGEFGVKEETNIVKLLEK 1434
                SL  D + + E  + A+R        K+ +   +    SG   +++E   ++    
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746

Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494
            Q +E+LEEE                      G  E  A S +     QQ +   NE  L+
Sbjct: 1747 QLEEELEEE---------------------QGNME--AMSDRVRKATQQAEQLSNE--LA 1781

Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFS 1554
             ++   Q  E+   + + + K L  +L E    +           E+K   L    E  +
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841

Query: 1555 KDKTFIVRQSIHDEISVSSMDAS-RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHM 1613
            ++K    +       S+   D   ++++L   Q+ED R ++  QY+E  +       A +
Sbjct: 1842 REKQAATK-------SLKQKDKKLKEILL---QVEDER-KMAEQYKEQAEK----GNARV 1886

Query: 1614 RQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE-NLVSERERVLLEELEALKQLSLAGRE 1672
            +Q++RQ E+ E   EE +R+N   A R  +  E +  +E    +  E+ ALK     G E
Sbjct: 1887 KQLKRQLEEAE---EESQRIN---ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940

Query: 1673 KLCCELRNSSTQTQNGNENQGEVEEQT 1699
                  R S  +    N +  E E  T
Sbjct: 1941 TSFVPSRRSGGRRVIENADGSEEETDT 1967



 Score =  132 bits (331), Expect = 9e-30
 Identities = 239/1148 (20%), Positives = 501/1148 (43%), Gaps = 119/1148 (10%)

Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
            ++RQ+E M+A+    E +L +  E+  K + E++ + E+    L ++   L+  ++ +  
Sbjct: 854  VTRQEEEMQAK----EDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETE 908

Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR----EHERDVFQQEIQKLE 2091
             + E E+ +    + L  + Q LE+ L +M   L+E+  DR    + ER    Q++  LE
Sbjct: 909  LYAEAEEMR----VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLE 963

Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151
            +QL+     +  +  Q  ++E++    K K  +  E+L+  +Q  +  +ER    + LE 
Sbjct: 964  EQLE-----EEEAARQKLQLEKVTAEAKIKKLE-DEILVMDDQNNKLSKER----KLLEE 1013

Query: 2152 RVRELEQALLVSADTFQKVEDRKHFGAVEAKPE---LSLEVQLQAERDAIDRKEKEITNL 2208
            R+ +L      + +  ++ E  K+   ++ K E     LEV+L+ E  +    EK    L
Sbjct: 1014 RISDL------TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067

Query: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2268
            E     F E++ +   ++ +L MQL  +++E    L  L+ E     + ++K    I+E 
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK----IREL 1123

Query: 2269 DAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLE 2328
            +   +  Q  L  + A   + ++ + D L E++  L+ +L+ T D+   +++    R+ E
Sbjct: 1124 EGHISDLQEDLDSERAARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQE 1182

Query: 2329 TQIECLMSDQEC---------VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2379
              +     D+E          +++   + +E+L E +E+ ++  AN+ +    N  +L +
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK----NKQTLEK 1238

Query: 2380 EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERES 2439
            E   L  +L V+   K  +E + +    ++  +++   +      +L  ++  L+ E ES
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1298

Query: 2440 VEKIQSIPE-NSVNVAID--HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIIN 2496
            V  + +  E  ++ +A D   LS    + + +L E+  + L   T  +  EE        
Sbjct: 1299 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ 1358

Query: 2497 LETRL---LQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIV 2547
            L+  +     LE  +S  +++L+   K+++D        E+G+   +  QK+I NL +  
Sbjct: 1359 LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK---KRFQKEIENLTQQY 1415

Query: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2607
            EEK AA      +LE  +   +   D+  +  + +R  + NL + +             +
Sbjct: 1416 EEKAAA----YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR------------K 1459

Query: 2608 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ 2667
              +L ++   + +    E+++   AE    EKE K L L + LE   + + E E+     
Sbjct: 1460 FDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKML 1516

Query: 2668 DVEVLKTTTELFHSNEESG-FFNELE----ALRAESVATKAELASYKEKAEKLQEELLVK 2722
              E+     +L  S ++ G   +ELE    AL  +    K +L   +++ +  ++  L  
Sbjct: 1517 KAEM----EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 2723 ETNMTSL----QKDLSQVRDHLAEAKEKLSILEKEDETEVQ-ESKKACMFEPLPIKLS-- 2775
            E NM +L    ++DL    +   E + +L     E ETE++ E K+  +      KL   
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632

Query: 2776 -KSIASQTDGTLK--ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQ 2832
             K +  Q D  +K    +  Q  ++  +    Q  L+   +S +  EI +   E  +K +
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD--EIFATAKENEKKAK 1690

Query: 2833 ELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHS 2892
             L  A+++ ++   ++  E  +++  +  + L EE  +  +    L+ ++      +A  
Sbjct: 1691 SLE-ADLMQLQ-EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748

Query: 2893 DAYQTREICSSDSGSD-WGQGIYLTHSQGFDIASE-GRGEESESATDSFPKKIKGLLRAV 2950
            +     E  + ++ SD   +          ++A+E    +++ESA     ++ K L   +
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1808

Query: 2951 HNEGMQVLSLTESPYS--DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE 3008
            H     V S  +S  +  + +   +++  E    E++A   ++      + ++ LQ E E
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868

Query: 3009 VYDSSQSHESFSDWRGEL-LLALQQVFLEERSVLLAAFRTEL-----TALGTTDAVGL-L 3061
               + Q  E        +  L  Q    EE S  + A R +L      A  + +A+G  +
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928

Query: 3062 NCLEQRIQ 3069
            N L+ +++
Sbjct: 1929 NALKSKLR 1936



 Score =  131 bits (329), Expect = 1e-29
 Identities = 213/1071 (19%), Positives = 450/1071 (42%), Gaps = 162/1071 (15%)

Query: 2    EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
            E+E+R ++L+A + K+AQ      +   +  + +QK + +  +++  +    D  +    
Sbjct: 940  EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999

Query: 62   CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
             N       + +E  +   +T        E   +      + ES IS        E    
Sbjct: 1000 QNNKLSKERKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE---- 1053

Query: 122  SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
                ++ +    L+ +  G    + EQ A D    +  ++ +LA K+ E++     L++ 
Sbjct: 1054 ---EKSRQELEKLKRKLEGDASDFHEQIA-DLQAQIAELKMQLAKKEEELQAALARLDD- 1108

Query: 182  RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
             +      L++++E E       G I+ L  +L   R  +++  ++  +L E+ + L+ +
Sbjct: 1109 EIAQKNNALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161

Query: 242  F----------QQLQASE-----TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLED 286
                       Q+L+A        L+ +    T +   Q ++    H Q +EE    LE 
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221

Query: 287  YQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----ETIIEELNTKIIEEE 342
            +++ K +       L+++    ++  + +V    K+E++ K    E  ++EL +K  + E
Sbjct: 1222 FKRAKANLDKNKQTLEKENA--DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279

Query: 343  KKTLELKDK-------LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIK 395
            +   EL DK       + +   +L E + + ++  +++ ++  +L ++++      EE +
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETR 1336

Query: 396  QLMGTVEELQKRNHKDSQFETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQELI 453
            Q +    +L++   + +  +  + + ME  Q  +R +  L  +L +       + K +  
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQDF 1390

Query: 454  RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNIKLQDTNSQKEKL 512
               +  +EE K R + E+EN  + Y       D++ K  N    EL+  + D ++Q++ +
Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450

Query: 513  KEELGLILEEKCALQRQLEDLV-EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL 571
                   LE+K   QR+ + L+ EE + S +      +  AE   K     K+LS    L
Sbjct: 1451 SN-----LEKK---QRKFDQLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARAL 1499

Query: 572  KAEIVSASESRKELELKHEAEVTNYKIKLEM--LEKEKNAV------LDRMAESQEAELE 623
            +          + LE K E E TN  +K EM  L   K+ V      L++   + E ++E
Sbjct: 1500 E----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 624  RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK----------DNLGIHYKQQIDGLQNE 673
             ++TQL     E+  +  ED ++   +N++ LK          D      ++Q+    +E
Sbjct: 1550 EMKTQL--EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607

Query: 674  MSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE------EMTLQINELQKE 727
               ++E  + ++      + +L  ++  L+    S +  + E      ++  Q+ + Q+E
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667

Query: 728  IEILR-----------QEEKEKGTLEQEVQELQ---LKTELLEKQMKEKENDLQEKFAQL 773
            +E  R           + EK+  +LE ++ +LQ      E   KQ   ++ +L E+ A  
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727

Query: 774  EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK 833
             +  + L+DEK+ LE  +       +EE                 +  +E + +      
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEE-----------------QGNMEAMSDRVRKAT 1770

Query: 834  QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL 893
            QQ  QL+ E+  +R+T   A+KN E   Q+L+ +     +++  L + +   + ++KS +
Sbjct: 1771 QQAEQLSNELATERST---AQKN-ESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTI 1823

Query: 894  KAL-----------NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942
             AL            +E   ++    ++K K     E    V +  +M E  ++   +  
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883

Query: 943  EKLEVTKR---EKLELSQRLSDLSEQLKQKHGEISFLNE----EVKSLKQE 986
             +++  KR   E  E SQR++    +L+++  E +  NE    EV +LK +
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934



 Score =  122 bits (306), Expect = 7e-27
 Identities = 253/1214 (20%), Positives = 509/1214 (41%), Gaps = 161/1214 (13%)

Query: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143
            ++E+Q  E +L+     Q  +E++ +E+EQ  + L E+ +   E L ++ +L  + +E  
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917

Query: 2144 EEI----EKLEFRVRELEQALLVSADTFQKVE-DRKHFGAVEAKPELSLEVQLQAERDAI 2198
              +    ++LE  + E+E  L    D  Q+++ +RK      A+  L LE QL+ E  A 
Sbjct: 918  VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM----AQQMLDLEEQLEEEEAAR 973

Query: 2199 DRKEKEITNLEEQLEQFREEL---ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2255
             + + E    E ++++  +E+   +++N ++ +    LE +  + TT L E E++ K   
Sbjct: 974  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033

Query: 2256 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2315
                K    I E +    +++     +  ++ ++ E +    +EQ+  LQ Q        
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQ-------- 1084

Query: 2316 VIEEKNELIRDLETQIECL--MSDQECVKRNREEEIEQLNEVIEKLQQELAN---IGQKT 2370
            + E K +L +  E     L  + D+   K N  ++I +L   I  LQ++L +      K 
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144

Query: 2371 SMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE-EMTFMKNVLKETNFKMNQLTQE 2429
                  L EE ++LK +L+  + +  A +Q++    E E+T +K  L E         QE
Sbjct: 1145 EKQKRDLGEELEALKTELEDTL-DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203

Query: 2430 LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEEN 2489
            +   ++  ++VE++    E     A  +L K+K  LE                    +EN
Sbjct: 1204 M--RQKHAQAVEELTEQLEQFKR-AKANLDKNKQTLE--------------------KEN 1240

Query: 2490 GKGSIINLETRLL-QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
                 +  E R+L Q +  V  K  +L    ++++     G+     L  K+  LQ  VE
Sbjct: 1241 AD---LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297

Query: 2549 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRI 2608
                   V+ +  EA  +  K  +D  ++SS+     +Q+  +L ++E    ++  T ++
Sbjct: 1298 S------VTGMLNEAEGKAIKLAKDVASLSSQ-----LQDTQELLQEETRQKLNVST-KL 1345

Query: 2609 SELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE--GNEKKQREKEKKRSP 2666
             +LE +   +   L  E E  +  E+++     +L + +K L+   +  +  E+ KKR  
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405

Query: 2667 QDVEVLKTTTELFHSNEESGFFNELEALRAE----------SVATKAELASYKEKAEKLQ 2716
            +++E L    E     E++  +++LE  +             +  + +L S  EK ++  
Sbjct: 1406 KEIENLTQQYE-----EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460

Query: 2717 EELLVKETNMTSLQKDLSQVRDHL-AEAKEK----LSILEKEDETEVQESKKACMFEPLP 2771
            ++LL +E N++S   D    RD   AEA+EK    LS+    +E    + +     + L 
Sbjct: 1461 DQLLAEEKNISSKYAD---ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517

Query: 2772 IKLSKSIASQTD---GTLKISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEK 2827
             ++   ++S+ D      ++  S +  +  ++    Q+  L+ E  + E  ++  +   +
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577

Query: 2828 IEKMQ---ELHAAEILDMESR---------HISETETLKREHYVAVQLLKEECGTLKAV- 2874
              K Q   +L A +  + E R         + +E E  +++  +A    K+  G LK + 
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1637

Query: 2875 IQCLRSKEG--SSIPELAHSDAYQT---REICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2929
            +Q   + +G   +I +L    A      RE+  + +  D    I+ T  +     +E + 
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD---EIFATAKE-----NEKKA 1689

Query: 2930 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2989
            +  E+      + +    RA     ++   L E   S     +  Q  +  LE R A   
Sbjct: 1690 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA--- 1746

Query: 2990 TISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTEL 3049
                          Q E E+ +   + E+ SD    +  A QQ   E+ S  LA  R+  
Sbjct: 1747 --------------QLEEELEEEQGNMEAMSD---RVRKATQQA--EQLSNELATERS-- 1785

Query: 3050 TALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLK 3109
            TA     A        Q+++ Q  E ++ +  ++ A +    S I AL A++      L+
Sbjct: 1786 TAQKNESA-------RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI----AQLE 1834

Query: 3110 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA 3169
             + E E   ++    +++QK  ++ E+ +++   +  A + +EQ       V +LK +L 
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894

Query: 3170 QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA 3229
            + + E +     + K  +EL+    E  +  + +    + L S+ ++  E  +   +   
Sbjct: 1895 EAEEESQRINANRRKLQRELD----EATESNEAMGREVNALKSKLRRGNETSFVPSRRSG 1950

Query: 3230 KLGRSEERDKEELE 3243
                 E  D  E E
Sbjct: 1951 GRRVIENADGSEEE 1964



 Score =  117 bits (292), Expect = 3e-25
 Identities = 242/1207 (20%), Positives = 495/1207 (41%), Gaps = 201/1207 (16%)

Query: 624  RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
            +++  L  + +EE  + KED        ++K K+      +Q+ +    E+ QK   +  
Sbjct: 847  KVKPLLQVTRQEEEMQAKED-------ELQKTKER-----QQKAENELKELEQKHSQLTE 894

Query: 684  EKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGT-L 741
            EK NL+ +Q Q   E+ ++ ++++  L   K E     + E+  E+E   +EE+++G  L
Sbjct: 895  EK-NLLQEQLQAETELYAEAEEMRVRLAAKKQE-----LEEILHEMEARLEEEEDRGQQL 948

Query: 742  EQEVQELQLKTELLEKQMKEKE-----------------NDLQEKFAQLEAENSILKDEK 784
            + E +++  +   LE+Q++E+E                   L+++   ++ +N+ L  E+
Sbjct: 949  QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008

Query: 785  KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844
            K LE+ +   T    EE     +  K K+K      E+E+ +++ E  +Q+  +L  ++E
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068

Query: 845  KQRNTFSFAEKNFEVNYQEL--------QEEYACLLKVKDDLEDSKN--KQELEYKSKLK 894
               + F     + +    EL        +E  A L ++ D++    N  K+  E +  + 
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128

Query: 895  ALNEELHLQRINPTTVKMKSSVFDED----KTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
             L E+L  +R      + +     E+    KT + +TL+     ++   +  +++ V K+
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188

Query: 951  EKLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENV 1009
               E ++      ++++QKH + +  L E+++  K+ K  +    + LE        EN 
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-------KENA 1241

Query: 1010 Q-SCDTQVSSLLDGVVTMTSRGAEGSVSKVNK--SFGEESKIMVEDKV--------SFEN 1058
              + + +V       V    +  E  V ++    S GE ++  + DKV        S   
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301

Query: 1059 MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRI 1118
            M    E K  +L  D     +  S L+ TQ    ++ +++LNV       LR Q+E +R 
Sbjct: 1302 MLNEAEGKAIKLAKD---VASLSSQLQDTQELLQEETRQKLNV----STKLR-QLEEERN 1353

Query: 1119 CLSLVYSTHVDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176
             L        DQ+ E ME ++  ++ + +L  +L     +  K+LQ           T E
Sbjct: 1354 SLQ-------DQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDF-------ASTVE 1395

Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYIS 1235
              +EGK       + QK +                E  T   + +  A DK E + + + 
Sbjct: 1396 ALEEGKK------RFQKEI----------------ENLTQQYEEKAAAYDKLEKTKNRLQ 1433

Query: 1236 ENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEE 1295
            +  D  + D      D Q  + + L K   ++++LL  +  +S  +  + D  + E  E+
Sbjct: 1434 QELDDLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 1296 -----NLPKEETEFLSIHSQM--------TNLEDIDVNHKSKLSSLQDLEKTK--LEEQV 1340
                 +L +   E L    ++          +ED+  +      ++ +LEK+K  LE Q+
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548

Query: 1341 QELESLISSLQQQLKETEQ-------NYEAEIHCLQKRLQAVSEST------VPPSLPVD 1387
            +E+++ +  L+ +L+ TE        N +A     ++ LQA  E        +   L   
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 1388 SVVITESDAQRTMYPGSCVKKNIDG---TIEFSGEFGVKEETNIVKLLE------KQYQE 1438
               + +   QR +   +  KK ++G    +E   +  +K     +K L       K +Q 
Sbjct: 1609 ETELEDERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGG----KENTASSKQAHAVCQQEQHYFNEMKLS 1494
            +LE+  A      + A   + +   +       +E+ A++++A      E+    E +L+
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE-ELA 1725

Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKEL-GEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553
                G    +    + +     L +EL  E G    +S+       +++     ++ E  
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 1554 SKDKTFIVRQ-----------SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ 1602
            +  K    RQ            +H+            +   E ++  + +++ ++ +E Q
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 1603 QATELLRQAHMR------QMERQREDQEQLQEE-------IKRLNRQLAQRSSIDNENLV 1649
             AT+ L+Q   +      Q+E +R+  EQ +E+       +K+L RQL + +  +++ + 
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EEAEEESQRIN 1904

Query: 1650 SERERVLLEELEALKQLSLAGRE--KLCCELRNSSTQTQNGNENQG---EVEEQTFKEKE 1704
            + R ++  E  EA +     GRE   L  +LR  +  +   +   G    +E     E+E
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1964

Query: 1705 LDRKPED 1711
             D +  D
Sbjct: 1965 TDTRDAD 1971



 Score = 82.8 bits (203), Expect = 6e-15
 Identities = 170/823 (20%), Positives = 351/823 (42%), Gaps = 127/823 (15%)

Query: 2931 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2990
            ++E+   +  ++++  L A   E  ++L   E+   + ED   Q  +E     RK     
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-----RKKMAQQ 958

Query: 2991 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL--------LALQQVFLEERSVLL 3042
            +  L++ + + +  R+    +   +         E+L        L+ ++  LEER   L
Sbjct: 959  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018

Query: 3043 AAFRTE-------LTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSE 3093
                 E       LT L       +++ LE R++++    Q   +  +K   D      +
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHE-SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 3094 IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3153
            I  L AQ+   K+ L +++E  + +   L+  I QK + + +++     ++   ++LQE 
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQED 1133

Query: 3154 LSSEKMV-------VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3206
            L SE+           +L  EL   K ELE TL +     +EL A R +      EV +L
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVL 1186

Query: 3207 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK---FSLESQKQRNLQLNLLL 3263
               L  E+ +S E Q  +++ + K  ++ E   E+LE  K    +L+  KQ   + N  L
Sbjct: 1187 KKAL-DEETRSHEAQ--VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243

Query: 3264 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3323
              + ++L +++Q++E ++   +AQ+ E Q +        + E+ R    +   D+  +L 
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSK------CSDGERAR----AELNDKVHKLQ 1293

Query: 3324 AQLQSSDGT---GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3380
             +++S  G     + +    ++D+   L  QL++      ELL E  + KL+     +Q+
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQ----ELLQEETRQKLNVSTKLRQL 1348

Query: 3381 EKDRQVHRKTLQTEQEAN--------------TEGQKKMHE--------------LQSKV 3412
            E++R   +  L  E EA               ++ +KK+ +               Q ++
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408

Query: 3413 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF------QKQELEREEKRESR--RILYQNL 3464
            E+L +Q EEK     KL+    RLQ  + +       Q+Q +   EK++ +  ++L +  
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468

Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELE----MIRQKLQ 3520
            N  + ++   DR       +  E ETK  + A+ +E          ELE    M++ +++
Sbjct: 1469 NISSKYADERDRAE----AEAREKETKALSLARALE---EALEAKEELERTNKMLKAEME 1521

Query: 3521 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ-QGEEPSLVSPST 3579
             + S    + +   E  + + A       ++  ++E+  QL++L  + Q  E + +    
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQLEELEDELQATEDAKLRLEV 1574

Query: 3580 SCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3639
            +  +L  +  R   +L     Q  E++  L+  + + E ++   R+  A    +++  L 
Sbjct: 1575 NMQALKGQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLE 1630

Query: 3640 GGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
            G    +  + ++  +  RE+    K L++ +A++   + EL +
Sbjct: 1631 GDLK-DLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELED 1670



 Score = 76.3 bits (186), Expect = 6e-13
 Identities = 119/577 (20%), Positives = 241/577 (41%), Gaps = 64/577 (11%)

Query: 3161 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK---KS 3217
            V   + E+   + EL+ T + Q K   EL+    +    T+E +LL + L +E +   ++
Sbjct: 854  VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913

Query: 3218 RELQWALEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3274
             E++  L  +K +L       E   EE ED    L++++++  Q  L LE+Q +    ++
Sbjct: 914  EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973

Query: 3275 QKIESQRMLYDAQLS---------EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3325
            QK++ +++  +A++          ++Q   L  +  L  E  RI ++++ L  E E    
Sbjct: 974  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE--RISDLTTNLAEEEEKAKN 1031

Query: 3326 LQSSDGTGQS---------RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3376
            L       +S         +    S   L++L+++LE   S   E + + +    +    
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091

Query: 3377 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE---- 3432
              + E++ Q     L  E        KK+ EL+  + DLQ  L+ +R    K + +    
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 3433 GQRLQGIMQEFQ--------KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3484
            G+ L+ +  E +        +QEL R ++ +   +L + L+E T       +       Q
Sbjct: 1152 GEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210

Query: 3485 KIEGETKESNYAKLIEMN---------GGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3535
             +E  T++    K  + N                 EL ++ Q  Q V  K + L  +  E
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270

Query: 3536 RLQFETADDEDF-IWVQENIDEIILQLQKLTGQQGE-EPSLVSPSTSCGSLTERL----- 3588
             LQ + +D E     + + + ++  +++ +TG   E E   +  +    SL+ +L     
Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329

Query: 3589 -----LRQNAELTGHISQLTEEKNDLRNMV---MKLEEQIRWYRQTGAGRDNSSRFSLNG 3640
                  RQ   ++  + QL EE+N L++ +   M+ ++ +  +  T   + + S+  L  
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389

Query: 3641 GANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLK 3677
             A+    +   K+ + +E   L +  +   A   KL+
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 92/466 (19%), Positives = 200/466 (42%), Gaps = 52/466 (11%)

Query: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240
            A +  L+  + +RL  K K     LL  T   E+ +++E +    KE+ +   +E ++ E
Sbjct: 831  AAYLKLRNWQWWRLFTKVKP----LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 886

Query: 3241 E----LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3296
            +    L + K  L+ Q Q   +L    E+ +  L   +Q++E      +A+L EE+ R  
Sbjct: 887  QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 946

Query: 3297 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL---------LKE 3347
            +LQ   +    ++ ++   L+ E     +LQ    T +++     +++         L +
Sbjct: 947  QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006

Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3407
             +K LEE+ S +   L E E+   +  + + + E         L+ E+++  E +K   +
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066

Query: 3408 LQSKVEDLQRQLEEKRQQVYKLDLE----GQRLQGIMQEFQKQELEREEKRESRRILYQN 3463
            L+    D   Q+ + + Q+ +L ++     + LQ  +     +  ++    +  R L  +
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126

Query: 3464 LNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ--- 3520
            +++               LQ+ ++ E    N A+  + + G      ELE ++ +L+   
Sbjct: 1127 ISD---------------LQEDLDSERAARNKAEKQKRDLG-----EELEALKTELEDTL 1166

Query: 3521 -CVASKLQVLPQKASERLQFETADDEDF----IWVQENIDEIILQLQKLTGQQGEEPSLV 3575
               A++ ++  ++  E    + A DE+       VQE   +    +++LT Q  +     
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ---FK 1223

Query: 3576 SPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3621
                +     + L ++NA+L G +  L + K ++ +   KLE Q++
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269



 Score = 70.5 bits (171), Expect = 3e-11
 Identities = 90/425 (21%), Positives = 184/425 (43%), Gaps = 61/425 (14%)

Query: 169  HEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ----------QAR 218
            HE+E+  R LE    T   E   QL+E E  ++  +    +L  N+Q          QAR
Sbjct: 1535 HELEKSKRALE----TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590

Query: 219  REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADL----LQAKQQILTHQ 274
             E++E  R   +L  Q  + + + +  +    L  +       DL    LQA   I   +
Sbjct: 1591 DEQNEEKRR--QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648

Query: 275  Q---QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331
            +   QL +    ++D+Q++ ED        +++I     E +KK ++   + +Q +E + 
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARAS----RDEIFATAKENEKKAKSLEADLMQLQEDLA 1704

Query: 332  EELNTKI---IEEEKKTLELKDKLTTADKLLGE---LQEQIVQKNQEIKNMKLELTNSKQ 385
                 +    +E+E+   EL   L+  + L  E   L+ +I Q  +E++  +  +     
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764

Query: 386  KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQI 445
            + R+++++ +QL   +   +    K+        +   Q+ +R+ ++LR++L EM G   
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGAVK 1816

Query: 446  VQMKQEL--IRQHMAQMEEMKTRHKGEMENALRSYSN--------ITVNEDQIKLMNVAI 495
             + K  +  +   +AQ+EE   +   E + A +S           +   ED+ K+     
Sbjct: 1817 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1876

Query: 496  NEL---NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE-------ELSFSREQIQ 545
             +    N +++    Q E+ +EE   I   +  LQR+L++  E       E++  + +++
Sbjct: 1877 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936

Query: 546  RARQT 550
            R  +T
Sbjct: 1937 RGNET 1941



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 91/505 (18%), Positives = 214/505 (42%), Gaps = 75/505 (14%)

Query: 4    EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63
            E++Q+K +   A+      + A    ++ ++ ++K+ K  S    +    +   +  + N
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513

Query: 64   EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
            +M       +E  V  +  + + +H  E+   ++    ++E E+ T  ++   E+     
Sbjct: 1514 KML---KAEMEDLVSSKDDVGKNVH--ELEKSKRALETQME-EMKTQLEELEDELQATED 1567

Query: 124  V-MRTGKPTNLLR---EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI-------E 172
              +R       L+   E +    D  +E+  +     L   E+EL  ++ +        +
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1627

Query: 173  ELNRELEEMRVTYGT------EGLQQLQEFEAAIKQ-----------RDGIITQLTANLQ 215
            +L  +L+++ +   +      E ++QL++ +A +K            RD I      N +
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687

Query: 216  QARREKDETMR--EFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA--DLLQAKQQIL 271
            +A+  + + M+  E L   E+++K Q   ++ + +E L +S     A   +  + + +I 
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARK-QADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746

Query: 272  THQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331
              +++LEE+   +E    +    T Q   L       E+  ++     N+   Q+ E   
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSN-----ELATERSTAQKNESARQQLERQN 1801

Query: 332  EELNTKIIEEEKKTL-ELKDKLTTADKLLGELQEQIVQ--------------KNQEIKNM 376
            +EL +K+ E E     + K  +   +  + +L+EQ+ Q              K++++K +
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861

Query: 377  KLELTNSKQKERQSSEE-------IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
             L++ + ++   Q  E+       +KQL   +EE ++        E+  +    ++ QR+
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--------ESQRINANRRKLQRE 1913

Query: 430  LEQLRAELDEMYGQQIVQMKQELIR 454
            L++   E +E  G+++  +K +L R
Sbjct: 1914 LDE-ATESNEAMGREVNALKSKLRR 1937


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.325 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 130,988,532
Number of Sequences: 37866
Number of extensions: 6234353
Number of successful extensions: 116445
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 740
Number of HSP's successfully gapped in prelim test: 1742
Number of HSP's that attempted gapping in prelim test: 28879
Number of HSP's gapped (non-prelim): 36081
length of query: 3907
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3785
effective length of database: 13,627,866
effective search space: 51581472810
effective search space used: 51581472810
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 72 (32.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press