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Search of human proteins with 22538387
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
(3907 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 7494 0.0
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 7472 0.0
gi|81295809 pericentrin [Homo sapiens] 313 3e-84
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 306 2e-82
gi|55770834 centromere protein F [Homo sapiens] 285 8e-76
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 241 1e-62
gi|71061468 centromere protein E [Homo sapiens] 239 4e-62
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 230 2e-59
gi|21735548 centrosomal protein 2 [Homo sapiens] 214 2e-54
gi|148746195 trichohyalin [Homo sapiens] 199 3e-50
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 191 9e-48
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 191 9e-48
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 191 9e-48
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 191 9e-48
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 191 9e-48
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 191 9e-48
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 191 9e-48
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 191 9e-48
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 182 6e-45
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 179 6e-44
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 171 1e-41
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 167 2e-40
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 167 2e-40
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 166 4e-40
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 164 2e-39
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 162 8e-39
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 159 4e-38
gi|148536869 ninein isoform 2 [Homo sapiens] 157 1e-37
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 157 3e-37
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 157 3e-37
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 7494 bits (19445), Expect = 0.0
Identities = 3907/3907 (100%), Positives = 3907/3907 (100%)
Query: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS
Sbjct: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG
Sbjct: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
Query: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180
CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE
Sbjct: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180
Query: 181 MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240
MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI
Sbjct: 181 MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240
Query: 241 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300
QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF
Sbjct: 241 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300
Query: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG
Sbjct: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
Query: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420
ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ
Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420
Query: 421 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN
Sbjct: 421 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
Query: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
Query: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600
REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL
Sbjct: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600
Query: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG
Sbjct: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
Query: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720
IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ
Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720
Query: 721 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780
INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL
Sbjct: 721 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780
Query: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840
KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN
Sbjct: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840
Query: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS
Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
Query: 961 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020
DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL
Sbjct: 961 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020
Query: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080
DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK
Sbjct: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080
Query: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD
Sbjct: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200
KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS
Sbjct: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200
Query: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260
YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL
Sbjct: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260
Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN
Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
Query: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380
HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV
Sbjct: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380
Query: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440
PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL
Sbjct: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440
Query: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500
EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF
Sbjct: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500
Query: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560
QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI
Sbjct: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560
Query: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620
VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR
Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620
Query: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN
Sbjct: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
Query: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK
Sbjct: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
Query: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800
TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800
Query: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860
SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA
Sbjct: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860
Query: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920
ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920
Query: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL
Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
Query: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160
QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL
Sbjct: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160
Query: 2161 LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2220
LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE
Sbjct: 2161 LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2220
Query: 2221 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2280
NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF
Sbjct: 2221 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2280
Query: 2281 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2340
GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC
Sbjct: 2281 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2340
Query: 2341 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400
VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ
Sbjct: 2341 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400
Query: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460
QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK
Sbjct: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460
Query: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK
Sbjct: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
Query: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2580
QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE
Sbjct: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2580
Query: 2581 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2640
PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE
Sbjct: 2581 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2640
Query: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700
KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA
Sbjct: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700
Query: 2701 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760
TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE
Sbjct: 2701 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760
Query: 2761 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI 2820
SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI
Sbjct: 2761 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI 2820
Query: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880
ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS
Sbjct: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880
Query: 2881 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP 2940
KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP
Sbjct: 2881 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP 2940
Query: 2941 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 3000
KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK
Sbjct: 2941 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 3000
Query: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060
MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL
Sbjct: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060
Query: 3061 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE 3120
LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE
Sbjct: 3061 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE 3120
Query: 3121 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3180
LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK
Sbjct: 3121 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3180
Query: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240
AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE
Sbjct: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240
Query: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300
ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV
Sbjct: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300
Query: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3360
LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV
Sbjct: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3360
Query: 3361 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3420
ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE
Sbjct: 3361 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3420
Query: 3421 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3480
EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW
Sbjct: 3421 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3480
Query: 3481 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE 3540
VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE
Sbjct: 3481 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE 3540
Query: 3541 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS 3600
TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS
Sbjct: 3541 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS 3600
Query: 3601 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL 3660
QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL
Sbjct: 3601 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL 3660
Query: 3661 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK 3720
TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK
Sbjct: 3661 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK 3720
Query: 3721 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF 3780
YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF
Sbjct: 3721 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF 3780
Query: 3781 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI 3840
LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI
Sbjct: 3781 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI 3840
Query: 3841 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3900
RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ
Sbjct: 3841 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3900
Query: 3901 FHAGMRR 3907
FHAGMRR
Sbjct: 3901 FHAGMRR 3907
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 7472 bits (19387), Expect = 0.0
Identities = 3899/3907 (99%), Positives = 3899/3907 (99%), Gaps = 8/3907 (0%)
Query: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS
Sbjct: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG
Sbjct: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
Query: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180
CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE
Sbjct: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180
Query: 181 MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240
MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI
Sbjct: 181 MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240
Query: 241 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300
QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF
Sbjct: 241 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300
Query: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG
Sbjct: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
Query: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420
ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ
Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420
Query: 421 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN
Sbjct: 421 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
Query: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
Query: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600
REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL
Sbjct: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600
Query: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG
Sbjct: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
Query: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720
IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ
Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720
Query: 721 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780
INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL
Sbjct: 721 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780
Query: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840
KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN
Sbjct: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840
Query: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS
Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
Query: 961 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020
DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL
Sbjct: 961 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020
Query: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080
DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK
Sbjct: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080
Query: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD
Sbjct: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200
KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS
Sbjct: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200
Query: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260
YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL
Sbjct: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260
Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN
Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
Query: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380
HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV
Sbjct: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380
Query: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440
PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL
Sbjct: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440
Query: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500
EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF
Sbjct: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500
Query: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560
QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI
Sbjct: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560
Query: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620
VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR
Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620
Query: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN
Sbjct: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
Query: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK
Sbjct: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
Query: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800
TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800
Query: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860
SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA
Sbjct: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860
Query: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920
ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920
Query: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL
Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
Query: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160
QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL
Sbjct: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160
Query: 2161 LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2220
L VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE
Sbjct: 2161 L--------VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2212
Query: 2221 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2280
NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF
Sbjct: 2213 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2272
Query: 2281 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2340
GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC
Sbjct: 2273 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2332
Query: 2341 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400
VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ
Sbjct: 2333 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2392
Query: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460
QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK
Sbjct: 2393 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2452
Query: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK
Sbjct: 2453 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2512
Query: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2580
QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE
Sbjct: 2513 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2572
Query: 2581 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2640
PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE
Sbjct: 2573 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2632
Query: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700
KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA
Sbjct: 2633 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2692
Query: 2701 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760
TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE
Sbjct: 2693 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2752
Query: 2761 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI 2820
SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI
Sbjct: 2753 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI 2812
Query: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880
ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS
Sbjct: 2813 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2872
Query: 2881 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP 2940
KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP
Sbjct: 2873 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP 2932
Query: 2941 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 3000
KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK
Sbjct: 2933 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 2992
Query: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060
MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL
Sbjct: 2993 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3052
Query: 3061 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE 3120
LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE
Sbjct: 3053 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE 3112
Query: 3121 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3180
LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK
Sbjct: 3113 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3172
Query: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240
AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE
Sbjct: 3173 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3232
Query: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300
ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV
Sbjct: 3233 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3292
Query: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3360
LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV
Sbjct: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3352
Query: 3361 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3420
ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE
Sbjct: 3353 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3412
Query: 3421 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3480
EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW
Sbjct: 3413 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3472
Query: 3481 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE 3540
VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE
Sbjct: 3473 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE 3532
Query: 3541 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS 3600
TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS
Sbjct: 3533 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS 3592
Query: 3601 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL 3660
QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL
Sbjct: 3593 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL 3652
Query: 3661 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK 3720
TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK
Sbjct: 3653 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK 3712
Query: 3721 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF 3780
YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF
Sbjct: 3713 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF 3772
Query: 3781 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI 3840
LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI
Sbjct: 3773 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI 3832
Query: 3841 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3900
RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ
Sbjct: 3833 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3892
Query: 3901 FHAGMRR 3907
FHAGMRR
Sbjct: 3893 FHAGMRR 3899
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 313 bits (801), Expect = 3e-84
Identities = 430/1880 (22%), Positives = 794/1880 (42%), Gaps = 311/1880 (16%)
Query: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI---LEISK---LKDLQQSL 709
+D G+H Q + GL+ +E ++ N+ T Q +L L+ K L +L++ L
Sbjct: 231 EDEAGLHQSQAVHGLE------LEALRLSLSNMHTAQLELTQANLQKEKETALTELREML 284
Query: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769
+ +++E+ L + Q E+E+LR++ +E +E+ L+ ++KEK EK
Sbjct: 285 NSRRAQELALLQSRQQHELELLREQHA------REKEEVVLRCGQEAAELKEKLQSEMEK 338
Query: 770 FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEE- 828
AQ+ KTL++ + E+ + L++++ K + + E+E L +
Sbjct: 339 NAQIV----------KTLKEDW-------ESEKDLCLENLR-KELSAKHQSEMEDLQNQF 380
Query: 829 NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK--QE 886
++L +Q +L E+I + +N A +N E ++Q A + K+++DL+ + ++
Sbjct: 381 QKELAEQRAEL-EKIFQDKNQAERALRNLESHHQ------AAIEKLREDLQSEHGRCLED 433
Query: 887 LEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
LE+K K ++L L+ + + +K+ +E + ++ L+ ++ +EL E+L
Sbjct: 434 LEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQ-LDSARTSRQELSELHEQL- 491
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRA 1006
L + R+ DL EQLKQ+ EK Q +L I
Sbjct: 492 ------LARTSRVEDL-EQLKQR----------------EKTQHESELEQLRIYFEKKLR 528
Query: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
+ ++ + T+ + +G+ E ++ D V VG E K
Sbjct: 529 DAEKTYQEDL--------TLLQQRLQGA---------REDALL--DSVEVGLSCVGLEEK 569
Query: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126
E+ DH+ + E + + Q EL + R Q+EA L + +
Sbjct: 570 PEKGRKDHVDELEPERHKESLP-----RFQAEL------EESHRHQLEALESPLCIQHEG 618
Query: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
HV C ++ + E E + H EL + Q D
Sbjct: 619 HVSD------------RCCVETSAL--GHEWRLEPSEGHSQELPWVHLQGVQD------- 657
Query: 1187 LIGKLQKAVSEECSYF-LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245
G L+ L+T V LK E+ EN Y + L+D
Sbjct: 658 --GDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKD- 714
Query: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG---------EEN 1296
D ++ H L+ +E N Q+T+ MK EF +E
Sbjct: 715 -----DLEKVKHNLIEDHQKELNNAK-----------QKTELMKQEFQRKETDWKVMKEE 758
Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEE-------QVQELESLISS 1349
L +E E L++ + L + + K + + +L + ++ + Q+ +LE ++
Sbjct: 759 LQREAEEKLTL--MLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTE 816
Query: 1350 LQQQLKETEQNYEAE--IHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGS-CV 1406
Q +L++ EQ+ ++ +HC Q E + ++ + E A + M S +
Sbjct: 817 QQGRLQQLEQDLTSDDALHCSQ----CGREPPTAQDGELAALHVKEDCALQLMLARSRFL 872
Query: 1407 KKNIDGTIEFSGEFGV------KEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTE 1460
++ + T +FS E ++ ++LL++++Q+QL + V+ + Q
Sbjct: 873 EERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQL------LSVTAELEARHQAA 926
Query: 1461 LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKE 1520
L ++ E+ + A V + + + ++ + + + ++++ + EF+ + +E
Sbjct: 927 LGELTASLESKQGALLAARVAELQTKHAADLGALETR-HLSSLDSLESCYLSEFQTIREE 985
Query: 1521 LGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQL 1580
H + + L +D E+++ KD S+H I ++ ++
Sbjct: 986 ---HRQALELLRAD-------------FEEQLWKKD-------SLHQTILTQELEKLKRK 1022
Query: 1581 MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR 1640
+E +L+ +R L + T + Q E E + L E+ + L Q AQ
Sbjct: 1023 --HEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQA 1080
Query: 1641 SSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTF 1700
E E+E + L+ + Q+ + L +++ Q E
Sbjct: 1081 QPFHQE----EKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENRE 1136
Query: 1701 KEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
L DV + +ER ALQ A RLL + E ++ + IG V LD +
Sbjct: 1137 GANLLSMLKADV--NLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDA 1194
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820
A ++ + E T +D ++P D ++ S V E
Sbjct: 1195 G-------------AGLALSTAPALEETW-SDVALPEL---DRTLSECAEMSSVAE---- 1233
Query: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880
+S + S E E E+ + + L AV+ L+E ++S QLE A+ + +
Sbjct: 1234 ISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEK 1293
Query: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQE 1940
E + +E + ++ +EL E L EES A+ +LA+EL K +G ++G+ E + +
Sbjct: 1294 EFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAG 1353
Query: 1941 KTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEK 2000
K D RL EL +LQ+ EQ ++EE L + EA +A E L +E E
Sbjct: 1354 KEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVED 1413
Query: 2001 LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEK 2060
L KE+ E + QAEK R L Q+K LE ++EEQ+S+ ++ + L QQ +L+K
Sbjct: 1414 LTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEA-VTALEQQVASLDK 1472
Query: 2061 QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTR------EVEQL 2114
L R+F+DEQA +REHER+ FQQEIQ+LE QL+ + QP ++ EVE L
Sbjct: 1473 HLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELL 1532
Query: 2115 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFR---------------------V 2153
L+EK D+ +EL + KE R + + EEI++LE V
Sbjct: 1533 QQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIV 1592
Query: 2154 RELEQ----------ALLVSADTFQKVEDRKHF-GAVEAKPELSLEVQLQAERDAIDRKE 2202
+ LEQ + L+ A T Q D P E+QL+ + A+ R+E
Sbjct: 1593 KGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRE 1652
Query: 2203 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK------D 2256
E+ +L+EQLE+ + +LE+KNEE+ L+++L++Q ++ L+ELE+EN K
Sbjct: 1653 SEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSS 1712
Query: 2257 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI------ 2310
++E+L I+ + Q +EK EI+QL+E + KLQ +L +
Sbjct: 1713 EIEELKATIENLQENQKRLQ-----------KEKAEEIEQLHEVIEKLQHELSLMGPVVH 1761
Query: 2311 -TTDNKVIEEKNELI---------RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2360
+D++ ++EL+ + L+ ++E + +E + R ++ + ++ +E LQ
Sbjct: 1762 EVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQ 1821
Query: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2420
Q L + + + L+ + + AE + +++ + + + E N
Sbjct: 1822 QRLQGAEEAAEL-------QLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874
Query: 2421 FKMNQLTQELFSLKRERESV 2440
+++ L Q + E E+V
Sbjct: 1875 LEIDALNQRKAAHSAELEAV 1894
Score = 307 bits (787), Expect = 1e-82
Identities = 290/1017 (28%), Positives = 496/1017 (48%), Gaps = 134/1017 (13%)
Query: 2940 PKKIKGLLRAVHNEGMQVLSLTE--SPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDL 2997
PK +K LL+ V +E Q+L+L+E +P S GE H ++ E ++D+
Sbjct: 2389 PKHVKALLQMVRDESHQILALSEGLAPPS-GEPHPPRKEDE---------------IQDI 2432
Query: 2998 ITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDA 3057
+E + DWRG+LL +Q+ F +E+ + + L+
Sbjct: 2433 SLHGGKTQEVPT--------ACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGH 2484
Query: 3058 VGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM------NGRKITLKR- 3110
LL LE+ I+EQG + ++E L+ DR SLLSEIQAL AQ+ N K+ R
Sbjct: 2485 SSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRT 2544
Query: 3111 ----------EQESEKPSQ-ELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKM 3159
+QE + Q ELL Y ++Q++ ++Q LS +++A +Q+ L++E+
Sbjct: 2545 ALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQT 2604
Query: 3160 VVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRE 3219
VV +LKS+L +++ + E ++ + +E+ R + K +E+ L SEQ K R
Sbjct: 2605 VVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRA 2664
Query: 3220 LQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES 3279
LQ LE+E+ + + E + + LE+L+ SLE+Q+ ++ +L + L+ ++ + Q+++
Sbjct: 2665 LQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRI 2724
Query: 3280 QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPL 3339
+ +A L++E+ + ELQ L +EK R E+S L ER L QL S T ++
Sbjct: 2725 EHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL--SQRTQEACVHQ 2782
Query: 3340 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3399
++ LQK EEK SR+V+L EK + +L ++QQ+E + Q H + L+ E+E +
Sbjct: 2783 DTQAHHALLQKLKEEK-SRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSA 2841
Query: 3400 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE--EKRESR 3457
+ + L ++ +L+ LE +R++ L E ++ ++E + ++ R E R+S
Sbjct: 2842 TLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSP 2901
Query: 3458 RILYQNLNEPTTWSLTSDRTRNWVLQQ-----KIEG--------ETKESNYAKLIEM--- 3501
Q W ++ R LQ+ KI+ E+K+ + +
Sbjct: 2902 AAAEQ----WRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSA 2957
Query: 3502 -NGGGTGCNH------ELEMIRQKLQCVASKLQVLPQKASERL--QFETADDEDFIWVQE 3552
G+ +H ELE +RQ+L A L +A +R + +++++ + +
Sbjct: 2958 RRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017
Query: 3553 NIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNM 3612
++E+ L + T Q + + + + LL+ N LT +S +T+EK +L
Sbjct: 3018 TLEELKSDLSRPTSSQKKMAAELQ-----FQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072
Query: 3613 VMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAE 3672
V KLE+ ++ + Q G SE+ W ++ Q SL+R +
Sbjct: 3073 VSKLEKLLKHHLQKGCSPSR-----------------SERSAWKPDETAPQSSLRRPDPG 3115
Query: 3673 VYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQEC 3732
+L ++ + +V ++++Y YLRAESFRKALIYQKKYLLLL+GGFQ+
Sbjct: 3116 --RLPPAASEEA-------HTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDS 3166
Query: 3733 EDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSV 3792
E TL+++A +G P+ + + IT+RP FTRFR+AVRV IAI R++FLV++W V
Sbjct: 3167 EQETLSMIAHLGVFPSKAERK-ITSRP--FTRFRTAVRVVIAILRLRFLVKKWQEV---- 3219
Query: 3793 SININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNR--- 3849
+R G L QG + PR D+ + P + R
Sbjct: 3220 ----DRKG-ALAQGKAPRP----GPRARQPQSPPRTRESPPTRDVPSGHTRDPARGRRLA 3270
Query: 3850 -----YPGTPADFNPGS-LACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3900
+ G A +P S L S + DP+ +LT+YI LE +Q+RLG + ST++
Sbjct: 3271 AAASPHSGGRATPSPNSRLERSLTASQDPEHSLTEYIHHLEVIQQRLGGVLPDSTSK 3327
Score = 145 bits (367), Expect = 6e-34
Identities = 381/1780 (21%), Positives = 698/1780 (39%), Gaps = 250/1780 (14%)
Query: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGF---AGTEIDP-----ENEEL 1842
T E ++ SD P M++K E+ EL+ + SG AG E E L
Sbjct: 191 TPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250
Query: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ-EATESLKCQEELRE 1901
L++S+ A +E T + L+ K T +RE ++ + L+ +++
Sbjct: 251 RLSLSNMHTAQLEL-------TQANLQKEKETALTELREMLNSRRAQELALLQSRQQHEL 303
Query: 1902 RLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL-----LCAS 1956
L E ARE+ V L + A+ K + ++++ I+ L+++ LC
Sbjct: 304 ELLREQHAREKEEVVLRCGQEA----AELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLE 359
Query: 1957 NRLQELEAEQQQIQEE-RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKV 2015
N +EL A+ Q E+ + ++ +AE + Q Q L + Q EK+
Sbjct: 360 NLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
Query: 2016 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075
R+DLQ + D+E +F E E+EK EL +L+ + L+ Q ++ + L Q
Sbjct: 420 REDLQSEHGRCLEDLE---FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDS 476
Query: 2076 REHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQL 2135
R QE+ +L +QL + ++EQL +EKT SEL EQL
Sbjct: 477 ARTSR----QELSELHEQLLA-------RTSRVEDLEQLKQ--REKTQHESEL----EQL 519
Query: 2136 QRDIQERNEEIEKLEFRVRELEQALLVSA---DTFQKVEDRKHFGAVEAKPELSLEVQLQ 2192
+ +++ + EK L Q L A VE +E KPE +
Sbjct: 520 RIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPE-------K 572
Query: 2193 AERDAIDRKEKEITNLEEQLEQFREELENKN-EEVQQLHMQLEIQKK-----ESTTRLQE 2246
+D +D E E +E L +F+ ELE + +++ L L IQ +
Sbjct: 573 GRKDHVDELEPE--RHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSA 630
Query: 2247 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQII-QEKEVEIDQLNEQVTKLQ 2305
L E +L + L + D + A+++ E E ++ Q++ LQ
Sbjct: 631 LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKV-----QLSLLQ 685
Query: 2306 QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN 2365
+LK + IE +N L L+ + L D E VK N +IE Q+EL N
Sbjct: 686 TELKEEIELLKIENRN-LYGKLQHETR-LKDDLEKVKHN----------LIEDHQKELNN 733
Query: 2366 IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ 2425
QKT + + K V+ E+L E A E++T M L+E Q
Sbjct: 734 AKQKTELMKQEFQRKETDWK-----VMKEELQRE-----AEEKLTLMLLELREKAESEKQ 783
Query: 2426 LTQELFSLKR-ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484
F L+ E ++ Q+ + ++ +LE LT D
Sbjct: 784 TIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREP 843
Query: 2485 SFEENGKGSIINLE----TRLLQLESTVSAKDLELTQCYKQ-----IKDMQEQGQFETEM 2535
++G+ + ++++ +L+ S + E+T+ + +++ QEQ E ++
Sbjct: 844 PTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQL 903
Query: 2536 LQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQ-----TISSEPERTNIQNLN 2590
LQ++ + Q+++ V A L ++ Q A+ E + Q +E + + +L
Sbjct: 904 LQER--HQQQLL--SVTAELEARHQ-AALGELTASLESKQGALLAARVAELQTKHAADLG 958
Query: 2591 QLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE--IAEKNVLEKEKKLLELQK 2648
L L S S + +SE ++ E +L L + E + +K+ L + EL+K
Sbjct: 959 ALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEK 1018
Query: 2649 LLEGNE-KKQREKEKKRSPQDVEVLKTTT-EL-------FHSNEESGFFNELEALRAESV 2699
L +E + Q ++ R+ E+ T EL F S +++ + E LR +S
Sbjct: 1019 LKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSA 1078
Query: 2700 ATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQ 2759
+ ++E+ E L +L K + L+ + + + E + +L +L++ E E +
Sbjct: 1079 QAQ---PFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENR 1135
Query: 2760 ESKKACMFEPLPIKLSKSIASQTDGTLK----------------ISSSNQTPQILVKNAG 2803
E + LS S L+ S + + + +AG
Sbjct: 1136 EGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAG 1195
Query: 2804 IQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQL 2863
+ L + + EE ++ + EL E ++E + RE ++
Sbjct: 1196 AGLALSTAPALEETWSDVA--------LPELDRTLSECAEMSSVAEISSHMRESFLMSPE 1247
Query: 2864 LKEEC-GTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDS--------GSDWGQGIY 2914
EC ++ V Q L S + E+A + Q E S ++ +
Sbjct: 1248 SVRECEQPIRRVFQSL-SLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVV 1306
Query: 2915 LTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQ 2974
H + + E ++E A + K +G L E + + + +H +
Sbjct: 1307 RKHQELLECLKEESAAKAELALEL--HKTQGTLEGFKVETADLKEVLAG--KEDSEHRLV 1362
Query: 2975 QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF 3034
E + + ++L++ T++ + EA D+ + +L +
Sbjct: 1363 LELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETR 1422
Query: 3035 LE---ERSVLLAAFRTELTAL--------GTTDAVGLLNCLEQRI---------QEQGVE 3074
+ +RS LL+ + + L G + LEQ++ Q Q ++
Sbjct: 1423 KQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMD 1482
Query: 3075 YQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ--------ELLEYNI 3126
QAA ++ +R EIQ L Q+ + K + + SQ ELL+ +
Sbjct: 1483 EQAAE---REHEREEFQQEIQRLEGQL---RQAAKPQPWGPRDSQQAPLDGEVELLQQKL 1536
Query: 3127 QQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHL 3186
++K + E+ ++ S DR +QE+ E + E+ + + +L+ ++ Q +
Sbjct: 1537 REKLDEFNELAIQKES-ADRQVLMQEE---EIKRLEEMNINIRKKVAQLQEEVEKQKNIV 1592
Query: 3187 KELEAFRLEVKDKTDEVHLLNDTLASEQKKSR-------------ELQWALEKEKAKLGR 3233
K LE + +K + LL TL S R E+Q + +
Sbjct: 1593 KGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRE 1652
Query: 3234 SEERD-KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQ 3292
SE D KE+LE +K LES+ + L LNL L+ Q S +++E +
Sbjct: 1653 SEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEE------------ 1700
Query: 3293 GRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL 3352
N L+V+ + I E+ +T++ +E +LQ + + L E+ ++L
Sbjct: 1701 --NTSLKVIY-TRSSEIEELKATIENLQENQKRLQ--------KEKAEEIEQLHEVIEKL 1749
Query: 3353 EEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKV 3412
+ + S + +++E + SLQ+ + + LQ E EA E ++ + L +
Sbjct: 1750 QHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA-- 1807
Query: 3413 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQ--EFQKQELER 3450
+++R+ L+ QRLQG + E Q ELER
Sbjct: 1808 -------DQERRHSQALEALQQRLQGAEEAAELQLAELER 1840
Score = 131 bits (329), Expect = 1e-29
Identities = 432/2144 (20%), Positives = 856/2144 (39%), Gaps = 331/2144 (15%)
Query: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
+E E+R++K+EAG+ KLA FR ++K K +S S+ + +D S
Sbjct: 3 VEQEQRRRKVEAGRTKLAHFR-------------QRKTKGDSSHSEKKTAKRKGSAVDAS 49
Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
E + +S + I ++ + G + +DC E
Sbjct: 50 VQEESPVTKE---DSALCGGGDICKSTSCDDTPDGAGG-------AFAAQPEDCDGEKRE 99
Query: 121 CSFVMRTGKPTNLLREE--EFGVDDSYSEQGAQ----DSPTHLEMM--ESELAGKQHEIE 172
++ + + E+ F V D EQ D P M S+ +QH +
Sbjct: 100 DLEQLQQKQVNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMF 159
Query: 173 ELNRELEEMRVTYGTEGLQQLQEFEAAIK----QRDGIITQLTANLQQARREKDETMREF 228
++ E R + Q Q + ++ GI T +Q E +E
Sbjct: 160 TVSDHPPEQRGMFTISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQEC 219
Query: 229 -LELT--EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE 285
L +T E ++ + Q QA L + +++ A+ ++ Q E++ L E
Sbjct: 220 ELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTE 279
Query: 286 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKT 345
+ +++ LQ + Q ++E ++ +EKE ++ + E ++K
Sbjct: 280 LREMLNSRRAQELALLQSR-------QQHELELLREQHAREKEEVVLRCGQEAAELKEKL 332
Query: 346 LELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQ--SSEEIKQLMGTVEE 403
+K K L E E +K+ ++N++ EL+ Q E + ++ K+L E
Sbjct: 333 QSEMEKNAQIVKTLKEDWES--EKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAE 390
Query: 404 LQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM----------KQELI 453
L+K +Q E ++ +E Q +E+LR +L +G+ + + KQ +
Sbjct: 391 LEKIFQDKNQAER-ALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLEL 449
Query: 454 RQHMAQMEEMKTRHKGE-------MENALRSYSNITVNEDQIKLMNVAINELNIKLQDTN 506
A E++K + + E +++A S ++ +Q+ + +L Q
Sbjct: 450 ENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREK 509
Query: 507 SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ-----------TIAEQE 555
+Q E E+L + E+K L+ + E+L+ ++++Q AR+ + E
Sbjct: 510 TQHESELEQLRIYFEKK--LRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLE 567
Query: 556 SKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE-----KEKNAV 610
K + K V++L+ E S R + EL+ +++ +LE LE + + V
Sbjct: 568 EKPEKGRK--DHVDELEPERHKESLPRFQAELEE-----SHRHQLEALESPLCIQHEGHV 620
Query: 611 LDRMAESQEAELERLRTQLLFSHEEELSKLK----EDLEIEHRINIEKLKDNLGI--HYK 664
DR A R + H +EL + +D ++E + E+ LG+ +K
Sbjct: 621 SDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLE--ADTERAARVLGLETEHK 678
Query: 665 QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
Q+ LQ E+ ++IE ++ E NL K + ++LKD + + ++ E+ ++N
Sbjct: 679 VQLSLLQTELKEEIELLKIENRNLYGK----LQHETRLKDDLEKVKHNLIEDHQKELNNA 734
Query: 725 QKEIEILRQEEKEKGT----LEQEVQ-ELQLKTELLEKQMKEK-ENDLQ---EKFAQLEA 775
+++ E+++QE + K T +++E+Q E + K L+ +++EK E++ Q KF EA
Sbjct: 735 KQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREA 794
Query: 776 ENSILKDEKKTLEDMLKIHTPVSQEE-RLIFLD-----------SIKSKSKDSVWEKEIE 823
E L+D++ +L + +++++ RL L+ S + + + E+
Sbjct: 795 EMRQLQDQQAA--QILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELA 852
Query: 824 ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKN 883
L + + Q + + +E+++ + QE QE++A L++ L++
Sbjct: 853 ALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQL---LQERHQ 909
Query: 884 KQELEYKSKLKALNE----ELHLQRINPTTVKMKSSVFDEDKTFVA-----ETLEMGEVV 934
+Q L ++L+A ++ EL + + + V + A ET + +
Sbjct: 910 QQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLD 969
Query: 935 EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG-EISFLNEEVKSLKQEKEQVSLR 993
++ L E + + + L +D EQL +K + L +E++ LK++ E
Sbjct: 970 SLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHE----- 1024
Query: 994 CRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDK 1053
EL+ + +H R T+VS+ L G V +G FG E K + +K
Sbjct: 1025 -GELQSVRDHLR--------TEVSTELAGTVAHELQGVH------QGEFGSEKKTALHEK 1069
Query: 1054 VSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQM 1113
T+ +S Q Q ++ SL +N ++Q+ LK + L ++
Sbjct: 1070 ----EETLRLQSAQAQPFHQE-----EKESLSLQLQKKNHQVQQ----LKDQVLSLSHEI 1116
Query: 1114 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK---IKELQKIHQLELQ 1170
E R L + + Q RE E L LK ++ + E+ L+++ L +
Sbjct: 1117 EECRSELEV-----LQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGE 1171
Query: 1171 TMKTQET-------------GDEGKPLHLLIGKLQKAVSEECS-YFLQTLCSVLGEYYTP 1216
T++ T D G L L A+ E S L L L E
Sbjct: 1172 TLRAAVTLRSRIGERVGLCLDDAGAGLAL---STAPALEETWSDVALPELDRTLSECAEM 1228
Query: 1217 ALKCEVNAEDKEN---SGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVL 1273
+ E+++ +E+ S + + E E P R Q + L+ + +L
Sbjct: 1229 SSVAEISSHMRESFLMSPESVRECEQP----IRRVFQSLSLAVDGLMEMALDSSRQLEEA 1284
Query: 1274 QTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK 1333
+ S+ + EF +N +E + + H ++ LE + +K +L K
Sbjct: 1285 RQIHSR--------FEKEFSFKN--EETAQVVRKHQEL--LECLKEESAAKAELALELHK 1332
Query: 1334 TKLEEQVQELESL-ISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVIT 1392
T+ + ++E+ + + +++E E+ L+++LQ ++
Sbjct: 1333 TQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQ--------------- 1377
Query: 1393 ESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452
E A R + T + E +++E + + + ++Q E++ + ++ M
Sbjct: 1378 EQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMK 1437
Query: 1453 IAFAQ-QTELSRISG-GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKF 1510
I ++ + +LS+ G K+ A + V ++H N+ + +Q + E + F
Sbjct: 1438 ILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREE--F 1495
Query: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS 1570
++E + L +L + K D P + L + +++ K F +E++
Sbjct: 1496 QQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVEL-LQQKLREKLDEF-------NELA 1547
Query: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630
+ A RQ+++ EE+++ + + + R+ QLQEE+
Sbjct: 1548 IQKESADRQVLMQEEEIKRLEEMNI----------------------NIRKKVAQLQEEV 1585
Query: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSL-AGREKLCCELRNSSTQTQNGN 1689
++ + + + D E L ++ LL L + Q +L AGR C E + S G
Sbjct: 1586 EK-QKNIVKGLEQDKEVLKKQQMSSLL--LASTLQSTLDAGR---CPEPPSGS--PPEGP 1637
Query: 1690 ENQGEVEEQTFKEKE---LDRKPEDVPPEILSNERYALQKANNRL--LKILLEVVKTTAA 1744
E Q EV ++ +E LD K E L + L+ N + L + L++ + A
Sbjct: 1638 EIQLEVTQRALLRRESEVLDLK------EQLEKMKGDLESKNEEILHLNLKLDMQNSQTA 1691
Query: 1745 VE----ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPS--- 1797
V E + I RSS+ + E +A++++ + E R+ E
Sbjct: 1692 VSLRELEEENTSLKVIYTRSSEIE---------ELKATIEN-LQENQKRLQKEKAEEIEQ 1741
Query: 1798 -YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEI-DPENEELMLNISSRLQAAVE 1855
+ + ++++++ V E ++ ++S ++ P + L + + L+A
Sbjct: 1742 LHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAK-- 1799
Query: 1856 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915
EA+S + E E +++ + +EA E + E L E E +A
Sbjct: 1800 ---EALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAE--VEDMAS 1854
Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
+ + E + A E T+ ER ++ ID L Q S ELEA + R
Sbjct: 1855 RIQEFEAALK--AKEATIAERNLE-----IDALNQRKAAHS---AELEAVLLALARIRRA 1904
Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV------QCQAE 2013
L +Q + A A P E Q L+ + +L+V +CQ E
Sbjct: 1905 LEQQ--PLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVE 1946
Score = 114 bits (286), Expect = 1e-24
Identities = 356/1734 (20%), Positives = 692/1734 (39%), Gaps = 266/1734 (15%)
Query: 2103 ISEHQTREVEQL-ANHLKEKTDKCSEL--LLSKEQLQRD--IQERNE-EIEKL-EFRVRE 2155
+S T ++E AN KEK +EL +L+ + Q +Q R + E+E L E RE
Sbjct: 254 LSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHARE 313
Query: 2156 LEQALL----VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERD-AIDRKEKEIT---- 2206
E+ +L +A+ +K++ A K +L+ ++E+D ++ KE++
Sbjct: 314 KEEVVLRCGQEAAELKEKLQSEMEKNAQIVK---TLKEDWESEKDLCLENLRKELSAKHQ 370
Query: 2207 -NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
+E+ QF++EL + E++++ K ++ L+ LE ++ +EKL +
Sbjct: 371 SEMEDLQNQFQKELAEQRAELEKIFQD----KNQAERALRNLESHHQAA---IEKLREDL 423
Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN-----------EQVTKLQQQL-KITTD 2313
+ +D L KF + +EK++E++ L E++ +L QL T
Sbjct: 424 QSEHGRCLED---LEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS 480
Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQK--TS 2371
+ + E +E + +++E L ++ K E E+EQL EK ++ Q+ T
Sbjct: 481 RQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTL 540
Query: 2372 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELF 2431
+ D+L ++V ++ + LE++ E ++ +++L E
Sbjct: 541 LQQRLQGAREDALLDSVEVGLS-CVGLEEKPEKGRKD-------------HVDELEPE-- 584
Query: 2432 SLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGK 2491
R +ES+ + Q+ E S ++ L D + + E +
Sbjct: 585 ---RHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSE 641
Query: 2492 GSIINLETRLLQLESTVSAKDLEL-TQCYKQIKDMQEQGQFETEMLQ---KKIVNLQKIV 2547
G L LQ V DLE T+ ++ ++ + + + +LQ K+ + L KI
Sbjct: 642 GHSQELPWVHLQ---GVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIE 698
Query: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2607
+ L + +L+ E K N + E N + +L + E + +
Sbjct: 699 NRNLYGKLQHETRLKDDLEKVKH---NLIEDHQKELNNAKQKTELMKQEFQRKETDWKVM 755
Query: 2608 ISELESQVVEMHTSLILE-KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSP 2666
EL+ + E T ++LE +E+ E ++ ++ K E E + R+ + +++
Sbjct: 756 KEELQREAEEKLTLMLLELREKAESEKQTIINK----------FELREAEMRQLQDQQAA 805
Query: 2667 QDVEVLKTTTELFHSNEESGFFNELE-------ALRAESVATKAELASYKEKAEKLQEEL 2719
Q +++ ++ TE + G +LE AL + A E A L
Sbjct: 806 QILDLERSLTE------QQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA-----L 854
Query: 2720 LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE--DETEVQESKKACMFEPLPIKLSKS 2777
VKE L S+ + E EK S + E + Q +++ + + + S
Sbjct: 855 HVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLS 914
Query: 2778 IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAA 2837
+ ++ + + + T + K Q + V E+ ++ + ++ H +
Sbjct: 915 VTAELEARHQAALGELTASLESK--------QGALLAARVAELQTKHAADLGALETRHLS 966
Query: 2838 EILDMESRHISETETLKREHYVAVQLLK----EECGTLKAVIQCLRSKEGSSIPELAHSD 2893
+ +ES ++SE +T++ EH A++LL+ E+ ++ Q + ++E + +
Sbjct: 967 SLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGE 1026
Query: 2894 AYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIK---GLLRAV 2950
R+ ++ ++ G QG + G E ++A + ++ +
Sbjct: 1027 LQSVRDHLRTEVSTELA-GTVAHELQG--VHQGEFGSEKKTALHEKEETLRLQSAQAQPF 1083
Query: 2951 HNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVY 3010
H E + LSL ++H +QQ+ + L + + I + + +Q +RE E
Sbjct: 1084 HQEEKESLSL----QLQKKNHQVQQLKDQVL----SLSHEIEECRSELEVLQQRRERENR 1135
Query: 3011 DSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTT------------DAV 3058
+ + +L A + ER L A R L G T + V
Sbjct: 1136 EGANLL--------SMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERV 1187
Query: 3059 GLLNCLEQRIQEQGVEYQAAME------CLQKADRR----SLLSEIQALHAQM-NGRKIT 3107
GL CL+ + A+E L + DR + +S + + + M ++
Sbjct: 1188 GL--CLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMS 1245
Query: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3167
+ +E E+P + + + ++ ++EM ++ S + A ++ + E E ++
Sbjct: 1246 PESVRECEQPIRRVFQ-SLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQ 1304
Query: 3168 LAQTKLELETTLKAQ-----------HKHLKELEAFRLEVKD-------KTDEVHLL--- 3206
+ + EL LK + HK LE F++E D K D H L
Sbjct: 1305 VVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLE 1364
Query: 3207 NDTLASEQKKSRELQWALEKEKAKL---GRSEERDKE--------ELEDL-KFSLESQKQ 3254
++L + +++ + Q AL +E +L G + D E E+EDL K E++KQ
Sbjct: 1365 LESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQ 1424
Query: 3255 RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVL-----LESEKVRI 3309
+ LL Q K L +E ++++ R E LE QV L +++ +
Sbjct: 1425 AEKDRSALLSQMKILESELEEQLSQHR---GCAKQAEAVTALEQQVASLDKHLRNQRQFM 1481
Query: 3310 REMSSTLDRER-ELHAQLQSSDG----TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLN 3364
E ++ + ER E ++Q +G + +P P + L ++E ++ E L+
Sbjct: 1482 DEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLD 1541
Query: 3365 ETEKYKLDSLQTRQQMEKDRQV--HRKTLQTEQEANTEGQKKMHELQSKVE---DLQRQL 3419
E + + Q+ DRQV + ++ +E N +KK+ +LQ +VE ++ + L
Sbjct: 1542 EFNELAI------QKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGL 1595
Query: 3420 EE-----KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTS 3474
E+ K+QQ+ L L LQ + + E E I E T +L
Sbjct: 1596 EQDKEVLKKQQMSSL-LLASTLQSTLDAGRCPEPPSGSPPEGPEIQL----EVTQRALLR 1650
Query: 3475 DRTRNWVLQQKIE---GETKESNYAKL-----IEMNGGGTGCN-HELEMIRQKLQCV--- 3522
+ L++++E G+ + N L ++M T + ELE L+ +
Sbjct: 1651 RESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTR 1710
Query: 3523 ASKLQVLP------QKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVS 3576
+S+++ L Q+ +RLQ E A++ E + E+I +LQ G VS
Sbjct: 1711 SSEIEELKATIENLQENQKRLQKEKAEE------IEQLHEVIEKLQHELSLMGPVVHEVS 1764
Query: 3577 PSTSCGSLTERLLRQNA------ELTGHISQLTEEKNDLRNMVMKLE----EQIRWYRQT 3626
S GSL LL A L G + E K L ++ E + + +Q
Sbjct: 1765 DS-QAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQR 1823
Query: 3627 GAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL 3680
G + ++ L A+ +E E + +LK EA + + E+
Sbjct: 1824 LQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEI 1877
Score = 97.8 bits (242), Expect = 2e-19
Identities = 350/1837 (19%), Positives = 718/1837 (39%), Gaps = 313/1837 (17%)
Query: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQ--LMLNEEQ-LEDMRQELV 1595
PE + + TIS+ + F E++++ +++ R+ L++ Q + + E +
Sbjct: 192 PEQRG-IFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250
Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
R + +L + Q Q+E + L E + LN + AQ + L+ R++
Sbjct: 251 RLSLSNMHTAQL----ELTQANLQKEKETALTELREMLNSRRAQELA-----LLQSRQQ- 300
Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK------EKELDRKP 1709
ELE L++ +E++ + + + +++ E Q K E E D
Sbjct: 301 --HELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCL 358
Query: 1710 EDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASL 1769
E++ E+ + + ++ N+ K E+ + A +E+
Sbjct: 359 ENLRKELSAKHQSEMEDLQNQFQK---ELAEQRAELEKIFQD------------------ 397
Query: 1770 IWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSG 1829
+++AE ++++ E H + E + R D+ +E + L
Sbjct: 398 --KNQAERALRNL--ESHHQAAIEKL---------REDLQ---------SEHGRCLEDLE 435
Query: 1830 FAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL--MRESFRQKQ 1887
F E + E + + N+ + + + E I SQL+ A+ ++ EL + E +
Sbjct: 436 FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLART 495
Query: 1888 EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTD--II 1945
E L+ Q + RE+ ES + K Y ++ TL ++++Q + ++
Sbjct: 496 SRVEDLE-QLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALL 554
Query: 1946 DRLEQELLCAS----------NRLQELEAEQQQ-----IQEERELLSR-QKEAMKA---- 1985
D +E L C + + ELE E+ + Q E E R Q EA+++
Sbjct: 555 DSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCI 614
Query: 1986 -EAGPVEQQLLQETEKLMKE-KLE-----------VQCQAEKVRD---DLQKQVKALEID 2029
G V + ET L E +LE V Q + D D ++ + L ++
Sbjct: 615 QHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLE 674
Query: 2030 VEEQVS---------RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE----QAIDR 2076
E +V IEL + +N L Q L+ LEK++ L E + +
Sbjct: 675 TEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNA 734
Query: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ----LANHLKEKTDKCSELLLSK 2132
+ + ++ +QE Q+ E KV+ E RE E+ + L+EK + + +++K
Sbjct: 735 KQKTELMKQEFQRKETDWKVM------KEELQREAEEKLTLMLLELREKAESEKQTIINK 788
Query: 2133 EQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVE------DRKH----------- 2175
+L+ E + ++ ++ +LE++L Q++E D H
Sbjct: 789 FELRE--AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTA 846
Query: 2176 ----FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHM 2231
A+ K + +L++ L R +RKE IT E+F E + +E Q+ H
Sbjct: 847 QDGELAALHVKEDCALQLMLARSRFLEERKE--IT------EKFSAEQDAFLQEAQEQHA 898
Query: 2232 QLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2291
+ E+Q + + Q L +L LG + + ++ ++ +L + A++ +
Sbjct: 899 R-ELQLLQERHQQQLLSVTAELEARHQAALG---ELTASLESKQGALLAARVAELQTKHA 954
Query: 2292 VEIDQLNEQVTKLQQQLK--ITTDNKVIEEKN----ELIR-DLETQI--------ECLMS 2336
++ L + L+ ++ + I E++ EL+R D E Q+ L
Sbjct: 955 ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014
Query: 2337 DQECVKRNREEEIEQLNEVIE-KLQQELANI----------GQKTSMNAHSLSEEADSLK 2385
+ E +KR E E++ + + + ++ ELA G+ S +L E+ ++L+
Sbjct: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074
Query: 2386 HQLDVVIA----EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL--KRERES 2439
Q EK +L Q++ N ++ +K+ + + ++ + EL L +RERE+
Sbjct: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134
Query: 2440 VEKIQSIPENSVNVAIDHLSKDKPEL----------EVVLTEDALKSLENQTYFKSFEEN 2489
E + +V + H + + E + L+S + ++
Sbjct: 1135 REGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDA 1194
Query: 2490 GKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKI--- 2546
G G ++ L + S V+ +L+ T + +M + + M + +++ + +
Sbjct: 1195 GAGLALSTAPALEETWSDVALPELDRT--LSECAEMSSVAEISSHMRESFLMSPESVREC 1252
Query: 2547 --------------VEEKVAAALVSQIQLE-AVQEYAKFCQDNQTISSEPE---RTNIQN 2588
V+ + AL S QLE A Q +++F ++ + E R + +
Sbjct: 1253 EQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQEL 1312
Query: 2589 LNQLREDELGSDISALTLRISELESQVVEMHTSLILE----KEQVEIAEKNVLEKEKKLL 2644
L L+E+ AL L ++ + ++ T+ + E KE E + VLE E
Sbjct: 1313 LECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSE--HRLVLELESLRR 1370
Query: 2645 ELQKLLE-------------------GNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES 2685
+LQ+ + + + RE ++ +D+ ++ T + S
Sbjct: 1371 QLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRS 1430
Query: 2686 GFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKE 2745
++++ L +E E S K E + E + SL K L R + E
Sbjct: 1431 ALLSQMKILESEL----EEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAA 1486
Query: 2746 KLSILEKEDETEVQ--ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAG 2803
+ +E + E+Q E + +P P S + DG +++ ++ N
Sbjct: 1487 EREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFN-- 1544
Query: 2804 IQINLQSECSSEEVTEIISQFTEKIEKMQELH------AAEILDMESRHISETETLKREH 2857
++ +Q E + +V E+I++++E++ A++ + + + + L+++
Sbjct: 1545 -ELAIQKESADRQVL----MQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDK 1599
Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTH 2917
V L K++ +L + + PE + EI + + +
Sbjct: 1600 EV---LKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQ----RALLRRE 1652
Query: 2918 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS 2977
S+ D+ + E+ + +S ++I L + + Q + +
Sbjct: 1653 SEVLDLKEQL--EKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTR 1710
Query: 2978 EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEE 3037
+EE KA TI +L++ ++Q ++ E+ Q HE + EL L + V E
Sbjct: 1711 SSEIEELKA---TIENLQENQKRLQKEKAEEI---EQLHEVIEKLQHELSL-MGPVVHEV 1763
Query: 3038 RSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQAL 3097
+ ++EL + A G R Q E +AA+E + R LL++ +
Sbjct: 1764 SDSQAGSLQSELLC---SQAGG------PRGQALQGELEAALEAKEALSR--LLADQERR 1812
Query: 3098 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3157
H+Q L+ Q+ + ++E E + + + + + E+ M R E + L ++
Sbjct: 1813 HSQ------ALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAK 1866
Query: 3158 KMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3194
+ +AE LE++ + + H ELEA L
Sbjct: 1867 EATIAE-------RNLEIDALNQRKAAHSAELEAVLL 1896
Score = 92.8 bits (229), Expect = 6e-18
Identities = 130/623 (20%), Positives = 264/623 (42%), Gaps = 68/623 (10%)
Query: 244 QLQASETLRNSTHSSTAADLLQAKQQI-LTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Q ++ E LR SS +++ + Q+ +TH Q E+ HL + + Q L+
Sbjct: 2502 QEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLR 2561
Query: 303 EKIKV--YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
++++ Y++EQ+K + ++ + E++ + + E+ +LK L + +
Sbjct: 2562 RQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
Query: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420
+L + + QE+ ++ L++ + + + + +E++ G LQ SQ E + ++
Sbjct: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQ------SQLEEEQLR 2675
Query: 421 RMEQETQ--RKLEQLRAELDEMYGQQ---IVQMKQE--------------------LIRQ 455
+++E+Q + LE+LRA L+ Q V +K E L+ Q
Sbjct: 2676 HLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQ 2735
Query: 456 HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK---EKL 512
+Q+ E++ E L + + ++ E + QDT + +KL
Sbjct: 2736 ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVH-QDTQAHHALLQKL 2794
Query: 513 KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL-STVEDL 571
KEE +++ LQ LE + ++ S++Q++ Q E + E +L STVE L
Sbjct: 2795 KEEKSRVVD----LQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEAL 2850
Query: 572 ---KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ 628
K E+ + E +E +AE+ +L+ E K A A A E+ R
Sbjct: 2851 HTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWR-- 2908
Query: 629 LLFSHEEELSKLKEDLEIEHRINIEKLKD----NLGIHYKQQIDGLQNEMSQKIETMQFE 684
+ + KL+E LE++ + ++ K+K + K ++ G + + +
Sbjct: 2909 ---KWQRDKEKLRE-LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSD 2964
Query: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744
D+L +Q +L +L + L + S+ + +N+ EK +L
Sbjct: 2965 ADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTS------SNEKAVMSLLHT 3018
Query: 745 VQELQLKTELLEKQMKEKENDLQEKFAQ--LEAENSILKDEKKTLEDMLKIHTPVSQEER 802
++EL+ K+ +LQ +F L+ S+ K ++ L++ VS+ E+
Sbjct: 3019 LEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK 3078
Query: 803 LIFLDSIK----SKSKDSVWEKE 821
L+ K S+S+ S W+ +
Sbjct: 3079 LLKHHLQKGCSPSRSERSAWKPD 3101
Score = 83.6 bits (205), Expect = 4e-15
Identities = 148/669 (22%), Positives = 283/669 (42%), Gaps = 100/669 (14%)
Query: 324 IQEKETIIEELNTKIIEEEKKTLELKDK---LTTADKLLGELQEQIVQKNQEIKNMKLEL 380
++ E II E + E+ + L L D+ L+ L +L+ +Q +++++++ L
Sbjct: 2488 LERLEKIIREQGD-LQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTAL 2546
Query: 381 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440
T++ E + S++ QL VE L + ++ D+ + + +E Q K +
Sbjct: 2547 TSA---EARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEE-QEKANSV------- 2595
Query: 441 YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK-LMNVAINELN 499
Q+++ +Q ++R + + E + + E RS + Q++ +++ NEL
Sbjct: 2596 --QKLLAAEQTVVRDLKSDLCESRQKS----EQLSRSLCEVQQEVLQLRSMLSSKENELK 2649
Query: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559
LQ+ S++ K + ALQ QLE+ E+L + + Q A+ + S
Sbjct: 2650 AALQELESEQGKGR-----------ALQSQLEE--EQLRHLQRESQSAKALEELRASLET 2696
Query: 560 EAHKSLSTVEDLKAEIVSASESRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAE 616
+ +S LK E + +KEL ++H EA + + +L L+K+ A R E
Sbjct: 2697 QRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLE 2756
Query: 617 SQEA-ELERLRTQLLFSHEEE-------------LSKLKEDLE--IEHRINIEKLKDNLG 660
EA ERL T+ L +E L KLKE+ ++ + +EK++
Sbjct: 2757 LSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQ-A 2815
Query: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720
+H +QQ++ E + E ++ EK+ T ++ + ++ ++L+ SL + + LQ
Sbjct: 2816 LHSQQQLEA---EAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQ 2872
Query: 721 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780
Q + QE ++ E ++ E K ++KE L+E Q + + +
Sbjct: 2873 AELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEK-LRELELQRQRDLHKI 2931
Query: 781 KDEKKTLEDM-LKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQL 839
K ++T+ D+ K P S RL + ++ D+ +E + E E ++Q+ +
Sbjct: 2932 KQLQQTVRDLESKDEVPGS---RLHLGSARRAAGSDADHLREQQ---RELEAMRQRLLSA 2985
Query: 840 NEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEE 899
R SF + + + +D S K + L+ L +
Sbjct: 2986 ------ARLLTSFTSQAVD--------------RTVNDWTSSNEKAVMSLLHTLEELKSD 3025
Query: 900 LHLQRINPTTVKMKSSVFDEDKTFVAET-LEMGEVVEKDTTELMEKLEVTKREKLELSQR 958
L PT+ K AE + +V+ KD L + L +EKLELS+
Sbjct: 3026 LS----RPTS---------SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072
Query: 959 LSDLSEQLK 967
+S L + LK
Sbjct: 3073 VSKLEKLLK 3081
Score = 75.5 bits (184), Expect = 1e-12
Identities = 89/426 (20%), Positives = 176/426 (41%), Gaps = 38/426 (8%)
Query: 1838 ENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE 1897
E ++ +L + S L + +L A+ E S+ + Q++L E R Q ++S K E
Sbjct: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688
Query: 1898 ELRERLHEESRAREQLAVELSKAEGVIDGYADEKTL----FERQIQEKTDIIDRLEQELL 1953
ELR L + +L V L + D E + E + ++ + L+++L
Sbjct: 2689 ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLA 2748
Query: 1954 CASNRLQEL-EAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA 2012
+R EL EA + + +L R +EA + LLQ+ ++ +++Q
Sbjct: 2749 AEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAML 2808
Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQ 2072
EKV+ + LE + ++ L +EK L+ +AL Q ++R
Sbjct: 2809 EKVQQQALHSQQQLEAEAQKHCE---ALRREKEVS-ATLKSTVEALHTQKRELR-----C 2859
Query: 2073 AIDREHERDVF-QQEIQKLEQQLK-----------VVPRFQPISEHQTREVEQLANHLKE 2120
+++RE E+ + Q E+++ +LK R P + Q R+ ++ L+E
Sbjct: 2860 SLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRE 2919
Query: 2121 KTDKCSELLLSKEQLQRDIQ--ERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGA 2178
+ L +QLQ+ ++ E +E+ + +A AD + E ++ A
Sbjct: 2920 LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLR--EQQRELEA 2977
Query: 2179 VEAKPELSLEVQLQAERDAIDR--------KEKEITNLEEQLEQFREELENKNEEVQQLH 2230
+ + + + A+DR EK + +L LE+ + +L +++
Sbjct: 2978 MRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMA 3037
Query: 2231 MQLEIQ 2236
+L+ Q
Sbjct: 3038 AELQFQ 3043
Score = 72.0 bits (175), Expect = 1e-11
Identities = 131/692 (18%), Positives = 294/692 (42%), Gaps = 90/692 (13%)
Query: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ-LEHA 1871
+V +E E Q + G E+ P L S L +EK++ + + LEH
Sbjct: 2455 QVVQEAFEKEQEM-----QGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHL 2509
Query: 1872 KVT-QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930
++ ++ L+ E ++L+ Q + ++E + A+ ++A G
Sbjct: 2510 RLPDRSSLLSE--------IQALRAQLRMTHLQNQEKLQHLRTALTSAEARG-------- 2553
Query: 1931 KTLFERQIQEKTDIID-RLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
+ E Q++ + +++ ++EQE A + + L EQ++ ++LL
Sbjct: 2554 -SQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSD 2612
Query: 1977 ---SRQK-EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032
SRQK E + V+Q++LQ L ++ E++ +++ + Q + +AL+ +EE
Sbjct: 2613 LCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESE-QGKGRALQSQLEE 2671
Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE- 2091
+ R ++ E + L +LR + Q ++ L + +++ + + E + E
Sbjct: 2672 EQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEA 2731
Query: 2092 ------QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL---------LLSKEQLQ 2136
QL + + + +T E+ + H + T++ S+ + L
Sbjct: 2732 LLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALL 2791
Query: 2137 RDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERD 2196
+ ++E + L+ + +++Q L S + E +KH A+ + E+S L++ +
Sbjct: 2792 QKLKEEKSRVVDLQAMLEKVQQQALHSQQQLE-AEAQKHCEALRREKEVS--ATLKSTVE 2848
Query: 2197 AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK-KESTTRLQELEQ------ 2249
A+ +++E L LE+ RE+ E++Q H +L+ Q+ +++ R E Q
Sbjct: 2849 ALHTQKRE---LRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAE 2905
Query: 2250 ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2309
+ + ++ D EKL +E + +D H + + Q +++ E + + ++ +
Sbjct: 2906 QWRKWQRDKEKL----RELELQRQRDLHKI-KQLQQTVRDLESKDEVPGSRLHLGSARRA 2960
Query: 2310 ITTDNKVIEEKNELIRDLETQIECLMS--------DQECVKRNREEEIEQLNEVIEKLQQ 2361
+D + E+ R+LE + L+S + V R + + + L
Sbjct: 2961 AGSDADHLREQQ---RELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017
Query: 2362 ELANIGQKTSMNAHSLSEEADSLKHQ-LDVVIAEKLALEQQVETANEE-MTFMKNVLKET 2419
L + S S + A L+ Q +DV++ + ++L + + T +E + + V K
Sbjct: 3018 TLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLE 3077
Query: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSV 2451
+ L + + ER + + ++ P++S+
Sbjct: 3078 KLLKHHLQKGCSPSRSERSAWKPDETAPQSSL 3109
Score = 60.1 bits (144), Expect = 4e-08
Identities = 155/746 (20%), Positives = 310/746 (41%), Gaps = 94/746 (12%)
Query: 1958 RLQELEAEQQQIQEERELLSRQKEAMKAEAG----PVEQQLLQETEKLMKEKLEVQCQAE 2013
R + ++A Q +++E + E + +G P ++ +Q+ + EV
Sbjct: 2388 RPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACP 2447
Query: 2014 KVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073
R DL + V+ E +EQ + +EL+ + DL + LE+ + +R+ D Q
Sbjct: 2448 DWRGDLLQVVQ--EAFEKEQEMQGVELQPRLSGS--DLGGHSSLLERLEKIIREQGDLQE 2503
Query: 2074 IDREH----ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
EH +R EIQ L QL++ L N +EK L
Sbjct: 2504 KSLEHLRLPDRSSLLSEIQALRAQLRMT---------------HLQN--QEKLQHLRTAL 2546
Query: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEV 2189
S E R Q+ ++ ++E ++EQ ++ D + + + E + S++
Sbjct: 2547 TSAEA--RGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSE-------EQEKANSVQK 2597
Query: 2190 QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2249
L AE+ + + ++ ++ EQ L +EV QL L ++ E LQELE
Sbjct: 2598 LLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES 2657
Query: 2250 E---NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKF-AQIIQEKEVEIDQLNEQVTK-- 2303
E + + +E+ L + ++ S + L Q Q + + +EQ K
Sbjct: 2658 EQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDN 2717
Query: 2304 LQQQLKI---TTDNKVIEEK---NELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
LQ++L+I + + +E+ +EL +DL + + E ++ R L E +
Sbjct: 2718 LQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHER-----LLTEQLS 2772
Query: 2358 KLQQELANIGQKTSMN---AHSLSEEAD---SLKHQLDVVIAEKLALEQQVETANEEMTF 2411
+ QE A + Q T + L EE L+ L+ V + L +QQ+E ++
Sbjct: 2773 QRTQE-ACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCE 2831
Query: 2412 MKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIP---ENSVNVAIDHLSKDKPELEV 2467
KE + + + L + KRE R S+E+ + P + + + L + +
Sbjct: 2832 ALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAA 2891
Query: 2468 VLTEDALKSLENQTYFKSFEENGKGSIINLET-------RLLQLESTV---SAKDLELTQ 2517
+ +A +S ++ ++ + K + LE ++ QL+ TV +KD E+
Sbjct: 2892 RRSAEARQSPAAAEQWRKWQRD-KEKLRELELQRQRDLHKIKQLQQTVRDLESKD-EVPG 2949
Query: 2518 CYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA-LVSQIQLEAVQEYAKFCQDNQT 2576
+ + + + L+++ L+ + + ++AA L++ +AV + D +
Sbjct: 2950 SRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVD---RTVNDWTS 3006
Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAE--- 2633
+ + + + L +L+ D L S+ +EL+ Q V+ +L K+ V + +
Sbjct: 3007 SNEKAVMSLLHTLEELKSD-LSRPTSSQKKMAAELQFQFVD-----VLLKDNVSLTKALS 3060
Query: 2634 ---KNVLEKEKKLLELQKLLEGNEKK 2656
+ LE + + +L+KLL+ + +K
Sbjct: 3061 TVTQEKLELSRAVSKLEKLLKHHLQK 3086
Score = 56.6 bits (135), Expect = 5e-07
Identities = 126/618 (20%), Positives = 244/618 (39%), Gaps = 104/618 (16%)
Query: 2 EDEERQKKLEAGKAKLAQFRQ---------RKAQSDGQSPSKKQKKKRKTSSSKH----D 48
E EE Q++++ + +L Q + ++A DG+ +QK + K
Sbjct: 1491 EREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQK 1550
Query: 49 VSAHHDLNIDQSQCN---EMYINSSQRV---ESTVIPESTIMRTLHSG-EITSHEQGFSV 101
SA + + + + EM IN ++V + V + I++ L E+ +Q S+
Sbjct: 1551 ESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSL 1610
Query: 102 ELESEISTTAD-------DCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSP 154
L S + +T D S G + + L RE E D
Sbjct: 1611 LLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESE-----------VLDLK 1659
Query: 155 THLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIK---QRDGIITQLT 211
LE M+ +L K EI LN +L+ M+ + L++L+E ++K R I +L
Sbjct: 1660 EQLEKMKGDLESKNEEILHLNLKLD-MQNSQTAVSLRELEEENTSLKVIYTRSSEIEELK 1718
Query: 212 A---NLQQ-ARREKDETMREFLELTEQSQKLQIQFQQL-----QASETLRNSTHSS---- 258
A NLQ+ +R + E E +L E +KLQ + + + S++ S S
Sbjct: 1719 ATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCS 1778
Query: 259 ---------------TAADLLQAKQQILTHQQQLEEQ--DHLLEDYQKKKEDFTMQISFL 301
A + +A ++L Q++ Q + L + Q +E +Q++ L
Sbjct: 1779 QAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAEL 1838
Query: 302 QEKIKVYEMEQDKKVENSNKEE--IQEKETIIEELNTKI--IEEEKK--TLELKDKLTTA 355
+ + + E E + + E ++ KE I E N +I + + K + EL+ L
Sbjct: 1839 ERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLAL 1898
Query: 356 DKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE 415
++ L++Q + ++ + RQ ++ + EL +R + +
Sbjct: 1899 ARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAH 1958
Query: 416 TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL 475
T + Q M G Q+ ++ H A +E + +G+++ L
Sbjct: 1959 TRVPGAHPQP-------------RMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVL 2005
Query: 476 RSYSN------------ITVNEDQIKLMNVAI-NELNIKLQDTNSQKEKLKEELGLILEE 522
+ + +TV + Q++ + + NE+ + L+D KEK+ E+ L +
Sbjct: 2006 VTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVD 2065
Query: 523 KCALQRQLEDLVEELSFS 540
A +QL++ + L +S
Sbjct: 2066 LVAQVKQLQEKLNRLLYS 2083
Score = 47.8 bits (112), Expect = 2e-04
Identities = 85/449 (18%), Positives = 180/449 (40%), Gaps = 95/449 (21%)
Query: 2471 EDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQ 2530
E ++ +E Q + G S++ ++++ + + K LE + + + E
Sbjct: 2464 EQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQA 2523
Query: 2531 FETEMLQKKIVNLQKIVEEKVAAA------------LVSQIQLEAVQEYAKFC---QDNQ 2575
++ + N +K+ + A L Q++L A + + C +
Sbjct: 2524 LRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQK 2583
Query: 2576 TISSEPERTN-IQNL---NQLREDELGSDI-------SALTLRISELESQVVEMHTSLIL 2624
T+S E E+ N +Q L Q +L SD+ L+ + E++ +V+++ + L
Sbjct: 2584 TLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSS 2643
Query: 2625 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2684
++ +++ A + + ++ K LQ LE + + ++E + S + +E L+ +
Sbjct: 2644 KENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQ-SAKALEELRAS--------- 2693
Query: 2685 SGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN-----------MTSLQKDL 2733
LE RA+S L + + LQ+EL ++ + ++ LQKDL
Sbjct: 2694 ------LETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
Query: 2734 SQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
+ + E E L E Q +++AC+ + + +
Sbjct: 2748 AAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQ------------------DTQAHHA 2789
Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETL 2853
Q L + ++LQ+ EK+++ Q LH+ + L+ E++ E L
Sbjct: 2790 LLQKLKEEKSRVVDLQA-------------MLEKVQQ-QALHSQQQLEAEAQ--KHCEAL 2833
Query: 2854 KREHYVAVQLLKEECGTLKAVIQCLRSKE 2882
+RE KE TLK+ ++ L +++
Sbjct: 2834 RRE--------KEVSATLKSTVEALHTQK 2854
Score = 42.7 bits (99), Expect = 0.007
Identities = 97/522 (18%), Positives = 198/522 (37%), Gaps = 90/522 (17%)
Query: 1568 EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ 1627
E+ + L E +L+ QEL + + + L + +R ++R+ + + L+
Sbjct: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688
Query: 1628 EEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687
E L Q AQ S +LC L++ T N
Sbjct: 2689 ELRASLETQRAQSS-------------------------------RLCVALKHEQTAKDN 2717
Query: 1688 GNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEE 1747
+KEL R +L+ ER L + L K L T + E
Sbjct: 2718 -------------LQKEL-RIEHSRCEALLAQERSQL----SELQKDLAAEKSRTLELSE 2759
Query: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807
+ RH + ++ S+ A + ++A ++ + EE +RV D
Sbjct: 2760 AL-RHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQA------------ 2806
Query: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQA----------AVEKL 1857
M KV ++ Q+L E +E+ + S ++A ++E+
Sbjct: 2807 --MLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
Query: 1858 LEAISETSSQLE--HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915
E + ++LE H ++ + E R++ R+ EA +S E+ R+ ++ + RE +
Sbjct: 2865 REKPAWLQAELEQSHPRLKEQE-GRKAARRSAEARQSPAAAEQWRKWQRDKEKLRE---L 2920
Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIID---RLEQELLCASNRLQELEAEQQQIQEE 1972
EL + + ++T+ R ++ K ++ L A + L +Q++++
Sbjct: 2921 ELQRQRDLHKIKQLQQTV--RDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAM 2978
Query: 1973 RE-LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031
R+ LLS + + V++ + T K + + E+++ DL + + +
Sbjct: 2979 RQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAA 3038
Query: 2032 EQVSRFIELEQEKNTE----LMDLRQQNQALEKQLEKMRKFL 2069
E +F+++ + N L + Q+ L + + K+ K L
Sbjct: 3039 ELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLL 3080
Score = 39.3 bits (90), Expect = 0.077
Identities = 59/279 (21%), Positives = 117/279 (41%), Gaps = 27/279 (9%)
Query: 3094 IQALHAQMNGRKITLKREQESE--KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3151
++ L + K+ R E E K + E L+ N ++ Q + E E+ + + +LQ
Sbjct: 1694 LRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAE---EIEQLHEVIEKLQ 1750
Query: 3152 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3211
+LS VV E+ A + L++ L +A + E++ + L+ LA
Sbjct: 1751 HELSLMGPVVHEVSDSQAGS---LQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA 1807
Query: 3212 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLN 3271
++++ + ALE + +L +EE + +L +L +RN+ L E + + +
Sbjct: 1808 DQERRHSQ---ALEALQQRLQGAEEAAELQLAEL--------ERNVALR---EAEVEDMA 1853
Query: 3272 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331
Q+ E+ +A ++E RNLE+ L + + E+ + L + L+
Sbjct: 1854 SRIQEFEAALKAKEATIAE---RNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPL 1910
Query: 3332 TGQSRPPLPS--EDLLKELQKQLEEKHSRIVELLNETEK 3368
+ PP L +QL+ H R + E ++
Sbjct: 1911 AAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDR 1949
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 306 bits (785), Expect = 2e-82
Identities = 629/3083 (20%), Positives = 1251/3083 (40%), Gaps = 460/3083 (14%)
Query: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
++D RQK ++ + A +RKA + K K + TS +K
Sbjct: 64 LKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK-------------- 109
Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
YI + TV+P S E S S E E EI +
Sbjct: 110 -----YIEEMKAQGGTVLPTEP-----QSEEQLSKHDKSSTEEEMEIEKIKHKLQEK--- 156
Query: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE---MMESELAGKQHEIEELNRE 177
L+ + + + +EQ AQ S T +E MM+ +L K+ I L +
Sbjct: 157 ----------EELISTLQAQLTQAQAEQPAQSS-TEMEEFVMMKQQLQEKEEFISTLQAQ 205
Query: 178 LEEMRVTYGTEGLQQLQE--FEAAIKQRDGIITQLTAN-------------LQQARREKD 222
L + + + + + ++ FE ++ + + QL LQ+ E +
Sbjct: 206 LSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHE 265
Query: 223 ETMR------EFL--ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
E++ + L ELT Q+ QI QQLQ E N+ ++ + ++K IL +
Sbjct: 266 ESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESK--ILLEK 323
Query: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEEIQEKETIIEE 333
+LE + L + ++E + F Q E+E + +E +K E++EK + I
Sbjct: 324 MELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383
Query: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393
L E + LKD+ KLL + EQ VQ Q I+ ++ +L +Q S+E
Sbjct: 384 LQKTGQELQSACDALKDQ---NSKLLQDKNEQAVQSAQTIQQLEDQL-------QQKSKE 433
Query: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL- 452
I Q + + Q + F + + T+ + L+ + E+ ++ + +
Sbjct: 434 ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
Query: 453 IRQHMAQMEEMKTR-----HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
+ + A+ E++ ++ + A R S I++ + K + A L++T S
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553
Query: 508 QKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL-- 565
QK K EL ++L E +++ EE++F + Q+Q R A+ E + K +
Sbjct: 554 QKHK---ELSVLLLE-------MKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEG 603
Query: 566 STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL 625
+ +K + V ++ ++ L + N + L +EKE+ + + S+E L
Sbjct: 604 EGIAPIKMK-VFLEDTGQDFPL-----MPNEESSLPAVEKEQASTEHQSRTSEEISLNDA 657
Query: 626 RTQLLFS-----------------HEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
+L + H++EL +LK + +E +N K ++ Y++ +D
Sbjct: 658 GVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI-LELELNFHKAQE----IYEKNLD 712
Query: 669 GLQNEMS---QKIETMQFEKDN-------LITKQNQLILEISKLKDLQQSLVNSKSEEMT 718
E+S Q IE + DN L +++QL+ ++ +L + + K EM
Sbjct: 713 EKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMN 772
Query: 719 LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778
L E Q+ ++ Q + L +++ L ++ + + +++ +N+L + Q +++
Sbjct: 773 LAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQST 831
Query: 779 ILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI------LIEENEDL 832
+++ + L++ K + ER+ + S + ++ +KE+EI L+E+ D+
Sbjct: 832 LIRSLQSQLQN--KESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDV 889
Query: 833 K--QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK 890
+ QQ I+ ++ + +FS EK ++N +E+++ +++K K++L
Sbjct: 890 ETLQQTIEEKDQ-QVTEISFSMTEKMVQLN----EEKFSLGVEIK------TLKEQLNLL 938
Query: 891 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
S+ + +E ++ N + +K + +D EM + EL + ++ K+
Sbjct: 939 SRAEEAKKE-QVEEDNEVSSGLKQN-YD----------EMSPAGQISKEELQHEFDLLKK 986
Query: 951 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE-KEQVSLRCREL-EIIINHNRAEN 1008
E + ++L K+ +S L EE+ +LK E K+++ L E E+ + E
Sbjct: 987 ENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY 1046
Query: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1068
+ C T ++ + T E + + K +E+K++ E +
Sbjct: 1047 SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD--------LEEKLAAEEQFQALVKQMN 1098
Query: 1069 QLILDHLPSVTKESSLRATQPSENDKLQKEL---NVLKSEQNDLRLQMEAQRICLSLVYS 1125
Q + D T + L + SEN + ++L N S+ + + L E ++V S
Sbjct: 1099 QTLQDK----TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE------TVVIS 1148
Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1185
E+ + E EE I A E++ ++LQK Q L + K
Sbjct: 1149 PPCTGSSEHWKPE--------LEEKILALEKEKEQLQKKLQEALTSRKA----------- 1189
Query: 1186 LLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDP--ELQ 1243
+ K E+ + + L +Y + + +++ EN GD + + + E
Sbjct: 1190 -----ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESI 1244
Query: 1244 DYRYEVQDFQEN------MHTLLNKVTEEYNKLLVLQTRLSKIW-GQQTDGMKLEFGEEN 1296
D + D QE+ + L K TE+++ VL++ L W D L+ G
Sbjct: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGG--- 1301
Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356
T I +Q+ +E V + K+SS E TK E+V +L+ I+ +++
Sbjct: 1302 -----TSVAQIKAQLKEIEAEKVELELKVSSTTS-ELTKKSEEVFQLQEQINKQGLEIES 1355
Query: 1357 TEQ-NYEAEIHC--LQKRLQAVSES--------TVPPSLPVDSVVITESDAQRTMYPGSC 1405
+ ++EAE+H LQ++L++ + P L +I++ + + G
Sbjct: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
Query: 1406 VKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL---EEEVAKVIVSMSIAFAQQTELS 1462
+K T + + E+ +++K L Q + Q +E + ++ V + + E+
Sbjct: 1416 SEKEAALT---KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIG 1472
Query: 1463 RISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG 1522
S K+ QA + ++E E K Q+++ + + L+K L
Sbjct: 1473 EESRAKQQIQRKLQAALISRKEA--LKENKSLQEELSLA---------RGTIERLTKSLA 1521
Query: 1523 EHGKEILLSNSDPHDIPESKDCVL----TISEEMFSKDKTFI-VRQSIHDEISVSSMDAS 1577
+ ++ N + KD VL + EE +DK + +S+ + S+SS S
Sbjct: 1522 DVESQVSAQNKE-------KDTVLGRLALLQEE---RDKLITEMDRSLLENQSLSSSCES 1571
Query: 1578 RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL 1637
+L L E L + +++LV++ E L+ + + + +E ++LQ+E + L L
Sbjct: 1572 LKLAL--EGLTEDKEKLVKE-------IESLKSSKIAESTEWQEKHKELQKEYEIL---L 1619
Query: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEE 1697
++ NE +ER + ++E + KQ + + Q Q + E++E
Sbjct: 1620 QSYENVSNE---AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKE 1676
Query: 1698 QTFK------------EKELDRKPEDV-PPEILSNERYALQKANNRLLKILLEVVKTTAA 1744
+ K E+E DR +V P + E ++N +K LE VK
Sbjct: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME-- 1734
Query: 1745 VEETIGRHVLGIL-DRSSKSQSSASLIWRSEAEASVKSCV-----HEEHTRVTDESIPSY 1798
ET+ + ++ ++ S S+ L + E S ++ + H+ T VT+E S
Sbjct: 1735 -YETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793
Query: 1799 SGSDMPRNDINMWSKVT----------------------EEGTELSQRL--VRSGFAGTE 1834
G ++ ++M ++ T +E Q++ ++ AG E
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
Query: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLE--HAKVTQTELMRESFRQKQEATES 1892
E ++ S L+ LL IS +L+ +VT+ L+ + +++
Sbjct: 1854 ---EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK 1910
Query: 1893 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952
LK E E+ E+L +L++ G I Y + T + QI+ + LE E+
Sbjct: 1911 LKETAE-----EEKDDLEERLMNQLAELNGSIGNYCQDVT--DAQIKN-----ELLESEM 1958
Query: 1953 LCASNRLQELEAEQQQIQEERELLSRQ--KEAMK----AEAGPVEQQLLQETEKLMKEKL 2006
+ ELE E+QQ+ +E+ + + KE ++ A+ P + +E ++L+KEK
Sbjct: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQ 2018
Query: 2007 EVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR 2066
+ Q +K Q+++ ALE V + F++ E +K DL + L + +E +
Sbjct: 2019 QEVKQLQKDCIRYQEKISALERTV--KALEFVQTESQK-----DLEITKENLAQAVEHRK 2071
Query: 2067 KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126
K E A + D + + L LK+ Q E +++Q L+ + ++
Sbjct: 2072 KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE 2131
Query: 2127 EL-LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL 2185
E L K+ +Q + E LE + E++ L Q++++ +
Sbjct: 2132 EKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFT 2191
Query: 2186 SLEVQLQAERD-AIDRKEKEITNLEEQLEQFREELENKNEEVQQLH---MQLEIQKKEST 2241
LQ +RD ID +K + ++ EE+ K + L Q+ I +E
Sbjct: 2192 KSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
Query: 2242 TRLQELEQENKLFKDDME-KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2300
+ LE + ++++ + ++ L K D + +++ +L +Q+ + + + NE
Sbjct: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELL----SQLEETRHLYHSSQNE- 2306
Query: 2301 VTKLQQQLKITTDNKV-IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2359
+ KL+ +LK D + E ++ + +E ++ QE +N + EQL ++
Sbjct: 2307 LAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS 2366
Query: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEK--------LALEQQVETANEEMTF 2411
++ + + ++ +M + + + V IAE LE + EE
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
Query: 2412 MKNVLKETNFKMNQLTQELFSLKRER--------ESVEKIQSIPENSVNVAIDHLSKDKP 2463
++ K+ K NQL + L ++K+E V+ + S+ + + D+ ++
Sbjct: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEER 2486
Query: 2464 ELEVVLTEDALKSLENQTYFKSFEENG--KGSIINLETRLLQLESTVSAKDLELTQCYKQ 2521
L ++L +D Q ++ EN K I L + + L S + D EL Q Y++
Sbjct: 2487 HLSIILEKD-------QLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQ-YRE 2538
Query: 2522 -------IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN 2574
IKD Q++ E ++ Q K E +YAK ++
Sbjct: 2539 DLNQVITIKDSQQKQLLEVQLQQNK----------------------ELENKYAKL-EEK 2575
Query: 2575 QTISSEPERTNIQNLNQLRED--ELGSDISALTLRISELESQVVEM---------HTSLI 2623
S E ++ N L+E+ +L +I +L + IS+L QV + H L
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLK 2635
Query: 2624 LEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE 2683
+++E+V +K++ EL++ E +KE + ++E K EL H +
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELEE-----ELVCVQKEAAKKVGEIED-KLKKELKHLHH 2689
Query: 2684 ESGFF-NELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAE 2742
++G NE E +L ++K + +E + S + +S +++
Sbjct: 2690 DAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDH 2749
Query: 2743 AKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNA 2802
A E+L L+++ + ++E + + L + ++ S+T ++ + N +
Sbjct: 2750 ANEELDELKRKYDASLKELAQ-LKEQGLLNRERDALLSETAFSMNSTEENSLSHL----- 2803
Query: 2803 GIQINLQSECSSEEVTEIISQFTEKIEKMQEL-HAAEILDMESRHISETETLKREHYVAV 2861
++N Q E++ + SQ + ++Q A L E H+ R+
Sbjct: 2804 -EKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGK 2862
Query: 2862 QLLKEECGTLKAVIQCLRSKEGS 2884
Q + T A +Q L+ S
Sbjct: 2863 QRSAAQPSTSPAEVQSLKKAMSS 2885
Score = 297 bits (761), Expect = 1e-79
Identities = 684/3361 (20%), Positives = 1389/3361 (41%), Gaps = 512/3361 (15%)
Query: 490 LMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
L NV ++EL+ + + L EL + + Q ED+ E L+++ + + +
Sbjct: 8 LANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQ-EDVQERLAYAEQLVVELKD 66
Query: 550 TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609
I +++ +L + ++L E+ KA A K+L+L +A++T+ +E ++ +
Sbjct: 67 IIRQKDVQLQQKDEALQ--EERKA----ADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT 120
Query: 610 VLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG 669
VL +S+E L H++ S +E++EIE + + K+ L + Q+
Sbjct: 121 VLPTEPQSEEQ---------LSKHDK--SSTEEEMEIEKIKHKLQEKEELISTLQAQLTQ 169
Query: 670 LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI---NELQK 726
Q E + T E + + + QL + + LQ L +++E+ Q+ + +
Sbjct: 170 AQAEQPAQSST---EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARF 226
Query: 727 EIEI-LRQEEKEKGTLEQEVQ-ELQLKTELLEKQMKEKENDL----------QEKFAQLE 774
E ++ L ++E + + +V+ E+Q K +L+++++E E L Q++ E
Sbjct: 227 ETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAE 286
Query: 775 AENSILKDEKKTLE---DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
N IL + + +E + L+ +EE I L+ ++ + V E+++ +
Sbjct: 287 QRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELE----VAERKLSF-----HN 337
Query: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKS 891
L+++ L E+ E+ A+ E Y L++++ ++ K S K E +S
Sbjct: 338 LQEEMHHLLEQFEQAGQ----AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQS 393
Query: 892 KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKRE 951
AL ++ N ++ K+ + + + + + K+ ++ + +L + + E
Sbjct: 394 ACDALKDQ------NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447
Query: 952 KLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 1010
+ +E + E I+ L + V L+ EK + L ELE + +AEN +
Sbjct: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL----KAEN-E 502
Query: 1011 SCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL 1070
+Q++ L T + +S V+ + S + EN T ++ K+ +
Sbjct: 503 KLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLEN-TFSQKHKELSV 561
Query: 1071 ILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC--LSLVYSTHV 1128
+L + +E + Q + + VL +Q +++ QME + I V+
Sbjct: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL--DQKEMK-QMEGEGIAPIKMKVFLEDT 618
Query: 1129 DQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188
Q M NE+ KE+ + + E ++ ++ T++ GD+ I
Sbjct: 619 GQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDI 678
Query: 1189 GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE 1248
G+ + E + L+ E+N + + + + E+ +
Sbjct: 679 GQCHQDELERLK--------------SQILELELNFHKAQEIYEKNLDEKAKEISNLNQL 724
Query: 1249 VQDFQENMH---TLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG---EENLPKEET 1302
+++F++N + ++EE ++LL LS + + +LE E + +
Sbjct: 725 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 784
Query: 1303 EFLSIHSQMTN--LEDIDVNHKSKLSSLQDLEKTKLEEQVQ--ELESLISSLQQQL--KE 1356
E + H + + + + KSK ++ L+ + Q+Q E +LI SLQ QL KE
Sbjct: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 844
Query: 1357 TEQNYEAE-IHCLQKRLQAVSESTVPPSLPVDSV----------------VITESDAQRT 1399
+E AE + + +++ +S++ L + + I E D Q T
Sbjct: 845 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 904
Query: 1400 MYPGSCVKKNIDGTIEFSGEFGV-----KEETNIVKLLEKQYQEQLEEEVAKVIVSMSIA 1454
S +K + E GV KE+ N++ E+ +EQ+EE+
Sbjct: 905 EISFSMTEKMVQLNEE-KFSLGVEIKTLKEQLNLLSRAEEAKKEQVEED----------- 952
Query: 1455 FAQQTELSRISGGKENTASSKQAHAVCQQE-QHYFNEMKLSQDQIGFQTFETVDVKFKEE 1513
E+S SG K+N A + ++E QH F+ +K +Q + + + KE
Sbjct: 953 ----NEVS--SGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRK-RKLQAALINRKEL 1005
Query: 1514 FKPLSK---ELG----EHGKEILLSNSDPHDIPESKD-------CVLTISEEMFSKDKTF 1559
+ +S+ EL E KEI LS ++ ++ E K+ CV + +E+
Sbjct: 1006 LQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEI-----EI 1060
Query: 1560 IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619
++Q+I ++ E +L+ +R++L + +Q L++Q M Q +
Sbjct: 1061 YLKQTISEK---------------EVELQHIRKDLEEKLAAEEQFQALVKQ--MNQTLQD 1103
Query: 1620 REDQ-EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678
+ +Q + LQ EI N+ + Q+ N + L++E + E EL
Sbjct: 1104 KTNQIDLLQAEISE-NQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL 1162
Query: 1679 RNSSTQTQNGNEN-QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN-NRLLKILL 1736
+ E Q +++E K + +K ++ + E QK + NRL +
Sbjct: 1163 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHL--REELKQQKDDYNRLQEQFD 1220
Query: 1737 EVVKTTAAVEETIGR-------HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTR 1789
E K + + + + + G L + + +S +S E + + HT+
Sbjct: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST---PGLEEPLFKATEQHHTQ 1277
Query: 1790 VTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSR 1849
ES D P + + + + GT ++Q + EI+ E EL L +SS
Sbjct: 1278 PVLESNLC---PDWPSHSED--ASALQGGTSVAQIKAQL----KEIEAEKVELELKVSS- 1327
Query: 1850 LQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRA 1909
T+S+L T+ E F+ +++ + E L+ HE
Sbjct: 1328 --------------TTSEL-------TKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVH 1366
Query: 1910 REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQI 1969
E L +L ++ I G + L + ++ E +I + E+++ S +L E EA +I
Sbjct: 1367 AESLQQKLESSQLQIAGLEHLREL-QPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI 1425
Query: 1970 QEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEID 2029
Q E + Q++ +KA +E Q + E++ + ++E+ C+ ++ +++ ++ +A
Sbjct: 1426 QTE---IIEQEDLIKALHTQLEMQAKEHDERIKQLQVEL-CEMKQKPEEIGEESRA---- 1477
Query: 2030 VEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQK 2089
++Q+ R ++ E + ++N++L+++L R ++ + DV Q +
Sbjct: 1478 -KQQIQRKLQAALISRKEAL---KENKSLQEELSLARGTIERLT---KSLADVESQVSAQ 1530
Query: 2090 LEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKL 2149
+++ V+ R + E + + + ++ L E S S E L+ ++ E+ EKL
Sbjct: 1531 NKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSS----SCESLKLALEGLTEDKEKL 1586
Query: 2150 EFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLE 2209
+ L+ + + + +Q+ KH +LQ E + + + + ++N
Sbjct: 1587 VKEIESLKSSKIAESTEWQE----KH-------------KELQKEYEILLQSYENVSNEA 1629
Query: 2210 EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESD 2269
E+++ E + + +E+ E KKE+ +LQE EQE + K+ M K
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKF-------- 1681
Query: 2270 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK-----ITTDNKVIEEKNELI 2324
A S Q Q I E E E D+L +V K + + N ++E+ E +
Sbjct: 1682 AKSKQ----------QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731
Query: 2325 R----DLETQIECLMSDQECVKRNREEEIEQLNEVIE------------KLQQELANIGQ 2368
+ L + + LMS+++ + EE++ L IE + N+ +
Sbjct: 1732 KMEYETLSKKFQSLMSEKDSLS----EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTE 1787
Query: 2369 KTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
+ + + +EE DSL +E + + A + + + +++QL +
Sbjct: 1788 EGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKE 1847
Query: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ-------- 2480
+ L+ E++ ++ EN N + +S EL+++ E +L NQ
Sbjct: 1848 RIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSR 1907
Query: 2481 -TYFKSFEENGKGSIIN-LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2538
T K E K + L +L +L ++ ++T Q + E+L+
Sbjct: 1908 VTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA-----------QIKNELLES 1956
Query: 2539 KIVNLQKIVEE--KVAAALVSQ---IQLEAVQEYAKFCQD------NQTISSEPE---RT 2584
++ NL+K V E + LV + ++ E +EY + Q N++ + E + +
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKE 2016
Query: 2585 NIQNLNQLRED--ELGSDISALTLRISELESQVVEMHTSLILEKE------------QVE 2630
Q + QL++D ISAL + LE E L + KE Q E
Sbjct: 2017 KQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAE 2076
Query: 2631 IAEKNVLEKEKKL---------LELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHS 2681
+A VL + + L+L+K L+ N K+ + + K+ +D+E E H
Sbjct: 2077 LASFKVLLDDTQSEAARVLADNLKLKKELQSN-KESVKSQMKQKDEDLERRLEQAEEKHL 2135
Query: 2682 NEESGFFNELEALRAESVATKAELASYK-------EKAEKLQEELLVKET-------NMT 2727
E+ +L+ALR E V + + + ++ ++LQE L T +M+
Sbjct: 2136 KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMS 2195
Query: 2728 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLK 2787
SLQ D +V D + + K S + E E++ + C L +L + + +
Sbjct: 2196 SLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV--LKDQLRQMSIHMEELKIN 2253
Query: 2788 ISSSNQTPQILVKNAGIQINLQSECSSE---EVTEIISQFTEKIEKMQELHAAEILDMES 2844
IS QI A ++ LQ + E E++SQ E+ + E+ +ES
Sbjct: 2254 ISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQL-EETRHLYHSSQNELAKLES 2312
Query: 2845 RHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSD 2904
S + L + +++ KE+ G L+ +I R +E + +T S +
Sbjct: 2313 ELKSLKDQLT-DLSNSLEKCKEQKGNLEGII---RQQEADIQNSKFSYEQLETDLQASRE 2368
Query: 2905 SGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESP 2964
S + I + + + S G+ E + A LR H++ ++ L E+
Sbjct: 2369 LTSRLHEEINMKEQKIISLLS-GKEEAIQVAIAE--------LRQQHDKEIKEL---ENL 2416
Query: 2965 YSDGEDHSI--QQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDW 3022
S E+ +I ++ ++ +++ + T+ ++K K +Q++A++ +S S +
Sbjct: 2417 LSQEEEENIVLEEENKKAVDKTNQLMETLKTIK----KENIQQKAQLDSFVKSMSSLQND 2472
Query: 3023 RGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECL 3082
R ++ QQ LEER + + + +L + +++E+ ++ M+ L
Sbjct: 2473 RDRIVGDYQQ--LEERHLSIILEKDQLIQEAAAE--------NNKLKEEIRGLRSHMDDL 2522
Query: 3083 QKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQK---QSQMLEMQVE 3139
++ L +E+ +N + IT+K Q+ ++LLE +QQ +++ +++ +
Sbjct: 2523 N-SENAKLDAELIQYREDLN-QVITIKDSQQ-----KQLLEVQLQQNKELENKYAKLEEK 2575
Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE---LEAFRLEV 3196
L ++ +L+ ++ + +L E+ K+ + + L Q L+E L + ++
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI-SQLTRQVTALQEEGTLGLYHAQL 2634
Query: 3197 KDKTDEVHLLNDTLASEQKKSRELQWAL---EKEKAK-LGRSEERDKEELEDL------- 3245
K K +EVH L+ +S QK+ EL+ L +KE AK +G E++ K+EL+ L
Sbjct: 2635 KVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIM 2694
Query: 3246 KFSLESQKQRNLQL--NLLLEQQKQLLNESQQK-IESQRMLYDAQLSEEQGR----NLEL 3298
+ E+ ++R +L +L+ +QK L+ + K + +Q + +S Q N EL
Sbjct: 2695 RNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL 2754
Query: 3299 QVLLESEKVRIREMSST-----LDRERE--LHAQLQSSDGTGQS---------RPPLPSE 3342
L ++E++ L+RER+ L S + T ++ + L +
Sbjct: 2755 DELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKD 2814
Query: 3343 DLLKELQKQLEEKHSRIVE--------------LLNETEKYKLDSLQTRQQMEKDRQVHR 3388
+ L L QLE+ ++++ L NE EK++ S + +Q+
Sbjct: 2815 EQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR-KSEEGKQRSAAQPSTSP 2873
Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV---YKLDLEGQRLQGIMQEFQ- 3444
+Q+ ++A + Q L ++++LQ+Q + Q++ + L + Q Q + FQ
Sbjct: 2874 AEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQI 2933
Query: 3445 KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGG 3504
QE R+E + L+Q E ++W + R + L + + + S+ LI
Sbjct: 2934 MQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI----- 2988
Query: 3505 GTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKL 3564
++L+ +S+ Q L + + ET+ D ++ + + L
Sbjct: 2989 ------------RELRSSSSQTQPLKVQYQRQASPETSASPD------GSQNLVYETELL 3030
Query: 3565 TGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYR 3624
Q + S + ++ LR +L + SQL EEKN L + + +R +
Sbjct: 3031 RTQLND---------SLKEIHQKELRIQ-QLNSNFSQLLEEKNTLSIQLCDTSQSLRENQ 3080
Query: 3625 Q 3625
Q
Sbjct: 3081 Q 3081
Score = 285 bits (729), Expect = 6e-76
Identities = 673/3382 (19%), Positives = 1376/3382 (40%), Gaps = 522/3382 (15%)
Query: 311 EQDKKVENSNKEEIQEKETIIEELNTKI-----------------IEEEKKT-------- 345
E D + N+ +E++QE+ E+L ++ ++EE+K
Sbjct: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKL 96
Query: 346 -LELKDKLTTADKLLGEL--------------QEQIVQKNQEIKNMKLELTNSKQKERQS 390
L K KLT+ +K + E+ +EQ+ + ++ ++E+ K K ++
Sbjct: 97 KLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEK 156
Query: 391 SEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450
E I L + + Q S E + M+Q+ Q K E + ++ Q Q Q
Sbjct: 157 EELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ 216
Query: 451 ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE 510
+++R+ A+ E H+ E+ + T + +++++ + E L +
Sbjct: 217 QVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVD 276
Query: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ--TIAEQESKLNEAHKSLS-- 566
L++EL + L +QL+ + E + R ++ R+ I ++ +L A + LS
Sbjct: 277 LLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH 336
Query: 567 ----TVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAV-LDRMAESQEAE 621
+ L + A +++ ELE ++ A K K EM EK + + L + + ++
Sbjct: 337 NLQEEMHHLLEQFEQAGQAQAELESRYSA--LEQKHKAEMEEKTSHILSLQKTGQELQSA 394
Query: 622 LERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681
+ L+ ++ SKL +D K+ + Q I L++++ QK + +
Sbjct: 395 CDALK--------DQNSKLLQD------------KNEQAVQSAQTIQQLEDQLQQKSKEI 434
Query: 682 QFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL 741
+ L +Q++ + S D+ + +EE I LQK + L E EKG L
Sbjct: 435 SQFLNRLPLQQHETASQTS-FPDVYNEGTQAVTEE---NIASLQKRVVEL---ENEKGAL 487
Query: 742 EQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE----DMLKIHTPV 797
EL+ ++K + L + LEA+N + +++ E D+ +
Sbjct: 488 LLSSIELE--------ELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSS 539
Query: 798 SQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNF 857
++E L++ S+ KE+ +L+ E ++ +++ L +++ +R + E
Sbjct: 540 AEESGQDVLENTFSQK-----HKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLD 594
Query: 858 EVNYQELQEEYACLLKVKDDLEDSKNKQEL--EYKSKLKALNEEL----HLQR------I 905
+ ++++ E +K+K LED+ L +S L A+ +E H R +
Sbjct: 595 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654
Query: 906 NPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE- 964
N V++KS+ D DK+ A ++G+ + ++LE K + LEL E
Sbjct: 655 NDAGVELKSTKQDGDKSLSA-VPDIGQCHQ-------DELERLKSQILELELNFHKAQEI 706
Query: 965 ---QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
L +K EIS LN+ ++ K+ A+N S T +S D
Sbjct: 707 YEKNLDEKAKEISNLNQLIEEFKK-------------------NADNNSSAFTALSEERD 747
Query: 1022 GVVTMTSR-----GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLP 1076
+++ V ++ + E + + ++ +E+ T + EQ+ H
Sbjct: 748 QLLSQVKELSMVTELRAQVKQLEMNLAEAER---QRRLDYESQTAHDNLLTEQI---HSL 801
Query: 1077 SVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYME 1136
S+ +S ++ VL++E +D++LQ Q + + S ++ E +E
Sbjct: 802 SIEAKSK------------DVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE 849
Query: 1137 N-EKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQET------GDEGKPLHLLIG 1189
E+ + + S EEL A +K E+ K+ QL L+ + ET + + +
Sbjct: 850 GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFS 909
Query: 1190 KLQKAVS-EECSYFLQTLCSVLGEYYT------PALKCEVNAEDKENSGDYISENEDPEL 1242
+K V E + L L E A K +V +++ +SG + +N D
Sbjct: 910 MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSG--LKQNYDEMS 967
Query: 1243 QDYRYEVQDFQENMHTLLNKVTEEYNKLL--------VLQTRLSKIWGQQTDGMKLEFGE 1294
+ ++ Q LL K E+ + L L R+S++ ++ +K E +
Sbjct: 968 PAGQISKEELQHEF-DLLKKENEQRKRKLQAALINRKELLQRVSRL-EEELANLKDE-SK 1024
Query: 1295 ENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQL 1354
+ +P ETE + N E + SK ++ K + E+ EL+ + L+++L
Sbjct: 1025 KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL 1084
Query: 1355 KETEQNYEAEIHCLQKRLQ------AVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKK 1408
EQ ++A + + + LQ + ++ + + + +IT + + VK+
Sbjct: 1085 AAEEQ-FQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
Query: 1409 N--IDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
I S E E + LEK+ +EQL++++ + + S + E R
Sbjct: 1144 TVVISPPCTGSSEHWKPELEEKILALEKE-KEQLQKKLQEALTSRKAILKKAQEKERHL- 1201
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIG-------FQTFETVDVKFKEE------ 1513
+E K + Q++ F+E + IG Q E++D K
Sbjct: 1202 -REELKQQKDDYNRLQEQ---FDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESC 1257
Query: 1514 ------FKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTI----SEEMFSKDKTFIVRQ 1563
+PL K +H + +L ++ D P + + S I +
Sbjct: 1258 SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE 1317
Query: 1564 SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMR-QMERQRED 1622
+ E+ VSS + +L E++ +++++ +Q E + + +A + + +Q+ +
Sbjct: 1318 KVELELKVSS--TTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Query: 1623 QEQLQ----EEIKRLNRQL--AQRSSIDNENLVSERERVLLEELEALK--QLSLAGREKL 1674
QLQ E ++ L +L Q+ E VS L E+ AL Q + +E L
Sbjct: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435
Query: 1675 CCELRNSSTQTQ-NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLK 1733
++ TQ + E+ +++ + E+ +KPE++ E S + +Q+ L
Sbjct: 1436 ---IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE--SRAKQQIQRKLQAALI 1490
Query: 1734 ILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVK---------SCVH 1784
E +K +++E + G ++R +KS + S+ A K + +
Sbjct: 1491 SRKEALKENKSLQEELSL-ARGTIERLTKSLADV----ESQVSAQNKEKDTVLGRLALLQ 1545
Query: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR-------SGFA-GTEID 1836
EE ++ E S + + E TE ++LV+ S A TE
Sbjct: 1546 EERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQ 1605
Query: 1837 PENEELMLNISSRLQA---------AVEKLLEAISETSSQLEHAKVTQTEL-MRESFRQK 1886
+++EL LQ+ ++ ++EA+ + +L + K+ TE +E+ +Q
Sbjct: 1606 EKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQEL-YGKLRSTEANKKETEKQL 1664
Query: 1887 QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE---------KTLFERQ 1937
QEA + + EE++E++ + +++++Q +EL + + +TL
Sbjct: 1665 QEAEQEM---EEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721
Query: 1938 IQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVE------ 1991
K + ++R++ E S + Q L +E+ + EE + L Q E ++ +E
Sbjct: 1722 ASMKEE-LERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD 1780
Query: 1992 ----------QQLLQETEKLMKEKLEVQ--CQAEKVRDDLQKQVKALEIDVEEQVSRF-- 2037
Q + ETE+ + + C + + ++++ +
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
Query: 2038 -IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI-------QK 2089
I+ +E+ L + +Q+N+ + LE + L Q ++ E + Q+E+ Q+
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
Query: 2090 LEQQLKVVPRFQPISEHQTREVEQ-LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEK 2148
++++L V + + +E + ++E+ L N L E Q + E++
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
Query: 2149 LEFRVRELEQ--ALLVSADTFQKVEDRKHF-----GAVEAKPELSLEVQLQAERDAIDRK 2201
L+ V ELE+ LV T + E RK + GA + S +LQ + + K
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ---ELLKEK 2017
Query: 2202 EKEITNLEEQLEQFREELENKNEEVQQLH-MQLEIQKKESTTR--LQELEQENKLFKDDM 2258
++E+ L++ +++E++ V+ L +Q E QK T+ L + + K + ++
Sbjct: 2018 QQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAEL 2077
Query: 2259 E--KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-----KIT 2311
K+ L +S+A ++ K ++ KE Q+ ++ L+++L K
Sbjct: 2078 ASFKVLLDDTQSEAARVLADNLKLKK--ELQSNKESVKSQMKQKDEDLERRLEQAEEKHL 2135
Query: 2312 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2371
+ K ++EK + +R + +E + + + +++E++QL E ++ +LA + S
Sbjct: 2136 KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMS 2195
Query: 2372 M---NAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
+ + +EA + + I K E+++ + + +K+ L++ + M +L
Sbjct: 2196 SLQDDRDRVIDEAKKWERKFSDAIQSK---EEEIRLKEDNCSVLKDQLRQMSIHMEELKI 2252
Query: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPEL----------------EVVLTED 2472
+ L+ +++ E D L + EL E+ E
Sbjct: 2253 NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLES 2312
Query: 2473 ALKSLENQ-TYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI---KDMQEQ 2528
LKSL++Q T + E K NLE + Q E+ + Q + +++ +
Sbjct: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSR 2372
Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
E M ++KI++L EE + A+ E Q++ K ++ + + S+ E NI
Sbjct: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIA-----ELRQQHDKEIKELENLLSQEEEENI-- 2425
Query: 2589 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL----EKEKKLL 2644
+ E+E + + ++L + + I +K Q++ K++ ++++ +
Sbjct: 2426 ---VLEEENKKAVD----KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
+ Q+L E + EK++ E K E+ G + ++ L +E+ AE
Sbjct: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEI------RGLRSHMDDLNSENAKLDAE 2532
Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA 2764
L Y+ E L + + +K++ L + Q L KL KE E ++ +++
Sbjct: 2533 LIQYR---EDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRS 2589
Query: 2765 CMFEPLPIK---LSKSIASQTDGTLKISSSNQTPQILVKNAGIQINL---QSECSSEEVT 2818
F L + LSK I S LK+S S T Q+ + L Q + EEV
Sbjct: 2590 --FNALQEEKQDLSKEIES-----LKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVH 2642
Query: 2819 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2878
+ + F+ +++ EL E++ ++ + ++ + ++ L + G ++ +
Sbjct: 2643 RLSALFSSSQKRIAELE-EELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETA 2701
Query: 2879 RSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF--DIASEGRGEES-ESA 2935
+ + ELA +++ + ++G I S GR S +++
Sbjct: 2702 EER----VAELARDLVEMEQKLL-----------MVTKENKGLTAQIQSFGRSMSSLQNS 2746
Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK 2995
D +++ L R ++ L E + E ++ +SE N++S L+
Sbjct: 2747 RDHANEELDELKRKYDASLKELAQLKEQGLLNRERDAL--LSETAFSMNSTEENSLSHLE 2804
Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTT 3055
L ++ + E ++ SSQ +S++ ++ S +A+ + E
Sbjct: 2805 KLNQQLLSKDEQLLHLSSQLEDSYNQ-------------VQSFSKAMASLQNERD----- 2846
Query: 3056 DAVGLLNCLEQ-RIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQES 3114
L N LE+ R E+G + AA A+ +SL +A+ + N R LK +
Sbjct: 2847 ---HLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK---KAMSSLQNDRDRLLKELK-- 2898
Query: 3115 EKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE 3174
N+QQ+ Q+ + EL +K + E Q++ + +++ EL+ E
Sbjct: 2899 ----------NLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE------- 2941
Query: 3175 LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS 3234
L QH EL R+E K S E+ KE+ + S
Sbjct: 2942 ---NLSWQH----ELHQLRME-------------------KSSWEIHERRMKEQYLMAIS 2975
Query: 3235 E-ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE-SQRMLYDAQLSEEQ 3292
+ ++ L++L L S + L ++ Q+Q E+ + SQ ++Y+ +L Q
Sbjct: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLK--VQYQRQASPETSASPDGSQNLVYETELLRTQ 3033
Query: 3293 GRNLELQVLLESEKVRIREMSSTLDR--ERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3350
N L+ + + E +RI++++S + E + +Q D T QS L+E Q+
Sbjct: 3034 -LNDSLKEIHQKE-LRIQQLNSNFSQLLEEKNTLSIQLCD-TSQS---------LRENQQ 3081
Query: 3351 QLEE--KHSRIVE-LLNETEKYKLDSLQTRQQMEKDRQVHRKT----LQTEQEANTEGQK 3403
+ H ++E + E + L+ ++ VHRK+ L+ Q++ +E Q+
Sbjct: 3082 HYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQ 3141
Query: 3404 KMHELQSKVEDLQRQLEEKRQQ 3425
++ + +V +L++ LEE+R Q
Sbjct: 3142 QLCNTRQEVNELRKLLEEERDQ 3163
Score = 225 bits (574), Expect = 6e-58
Identities = 596/3013 (19%), Positives = 1245/3013 (41%), Gaps = 417/3013 (13%)
Query: 932 EVVEKDTTELMEKLEVTKREKLELSQRLS-DLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990
E+ ++ E + +E+L +++L +L + ++QK + L ++ ++L++E++
Sbjct: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQ---LQQKDEALQEERKAA 89
Query: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLL--DGVVTMTSRGAEGSVSKVNKSFGEESKI 1048
+ ++L++ H +A+ + S + + + G V T +E +SK +KS EE
Sbjct: 90 DNKIKKLKL---HAKAK-LTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEME 145
Query: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108
+ + K + ++E+LI +T+ +A QP+++ +E ++K + +
Sbjct: 146 IEKIKHKLQ--------EKEELISTLQAQLTQA---QAEQPAQSSTEMEEFVMMKQQLQE 194
Query: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLE 1168
+ + LS T +Q + + EKD E + E+++ LQ + Q +
Sbjct: 195 KEEFISTLQAQLS---QTQAEQAAQQVVREKDARF----ETQVRLHEDEL--LQLVTQAD 245
Query: 1169 LQTMKTQETGDEGKPLH----LLIGKLQ---------KAVSEECSYFLQTLCSVLGEYYT 1215
++T Q+ + L L+G+ Q A + Q L + E+ T
Sbjct: 246 VETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT 305
Query: 1216 PALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQT 1275
L+ V E +E+ + E + E+ + + + QE MH LL + + L++
Sbjct: 306 --LRNTVETEREESK--ILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361
Query: 1276 RLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK 1335
R S + +Q ++E ++ + + S L+D SKL LQD K
Sbjct: 362 RYSAL--EQKHKAEMEEKTSHILSLQKTGQELQSACDALKD----QNSKL--LQD----K 409
Query: 1336 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL-----QAVSESTVPPSLPVDSVV 1390
E+ VQ +++ QQL++ Q EI RL + S+++ P +
Sbjct: 410 NEQAVQSAQTI-----QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQA 464
Query: 1391 ITESDAQRTMYPGSCVKKNIDGTIEFSG----EFGVKEE--TNIVKLLEKQYQE-QLEEE 1443
+TE + ++ +N G + S E + E ++ + LLE Q + + + E
Sbjct: 465 VTEENIA-SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523
Query: 1444 VAKVIVSMSIAFAQQTELSRISGGK---ENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500
V+++ + + A + S G+ ENT S K ++ EMK +Q++I F
Sbjct: 524 VSEISI---VDIANKRSSSAEESGQDVLENTFSQKH-----KELSVLLLEMKEAQEEIAF 575
Query: 1501 QTFETVDVKFKE---------EFKPLSKE----------LGEHGKEILLSNSDPHDIPE- 1540
+ + +E E K + E L + G++ L ++ +P
Sbjct: 576 LKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635
Query: 1541 -----SKDCVLTISEEMFSKDKTFIVRQSIHD-EISVSSMDASRQLMLNEEQLEDMRQEL 1594
S + SEE+ D ++ + D + S+S++ Q ++++LE ++ ++
Sbjct: 636 EKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC--HQDELERLKSQI 693
Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL---NRQLAQRSSIDNENLVSE 1651
+ +A E+ + ++ + ++ + QL EE K+ N S + + L+S+
Sbjct: 694 LELELNFHKAQEIYEK-NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752
Query: 1652 -RERVLLEELEA-LKQL--SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDR 1707
+E ++ EL A +KQL +LA E+ R ++Q ++N + + ++
Sbjct: 753 VKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYESQTAHDN---LLTEQIHSLSIEA 805
Query: 1708 KPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSA 1767
K +DV E+L NE +Q + ++ + E + + SSK + +
Sbjct: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
Query: 1768 SLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR 1827
+ + E E + + E R + + D +I+ +TE+ +L++
Sbjct: 866 QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISF--SMTEKMVQLNEEKFS 923
Query: 1828 SGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ 1887
G EI E+L N+ SR + A ++ +E +E SS L+ + + S + Q
Sbjct: 924 ---LGVEIKTLKEQL--NLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978
Query: 1888 EATESLKCQEELRER-LHEESRAREQLAVELSKAEGVIDGYADEKT----LFERQIQEKT 1942
+ LK + E R+R L R++L +S+ E + DE L E + E
Sbjct: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038
Query: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEEREL-LSRQKEAMKAEAGPVEQQLLQETEKL 2001
+ + E C +++ QE+E +Q E+E+ L ++ ++ + EQ Q K
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQ--FQALVKQ 1096
Query: 2002 MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ 2061
M + L+ D Q+ L+ ++ E + I+ NT+ D + AL K+
Sbjct: 1097 MNQTLQ----------DKTNQIDLLQAEISENQA-IIQKLITSNTDASD--GDSVALVKE 1143
Query: 2062 L-----------EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
E + L+E+ + E E++ Q+++Q+ K + + E RE
Sbjct: 1144 TVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE 1203
Query: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKV 2170
LK++ D + L ++ ++ + +++ +L+ +VRE L S D +
Sbjct: 1204 ------ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESC 1257
Query: 2171 E-----DRKHFGAVE---AKPELSLEV---------------------QLQAERDAIDRK 2201
+ F A E +P L + Q++A+ I+ +
Sbjct: 1258 SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE 1317
Query: 2202 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-----LEIQKKESTTRLQELEQENKLFKD 2256
+ E LE ++ EL K+EEV QL Q LEI+ ++ + E+ E+ K
Sbjct: 1318 KVE---LELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL 1374
Query: 2257 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-KITTDNK 2315
+ +L +A E ++ + ++I +KE ++ L+ Q+++ + L KI T+
Sbjct: 1375 ESSQLQIAGLEH----LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE-- 1428
Query: 2316 VIEEKNELIRDLETQIECLMSDQE----------CVKRNREEEIEQLNEVIEKLQQEL-- 2363
I E+ +LI+ L TQ+E + + C + + EEI + + +++Q++L
Sbjct: 1429 -IIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487
Query: 2364 ANIGQKTSMNAH-SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422
A I +K ++ + SL EE + ++ + +E QV N+E + L +
Sbjct: 1488 ALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEE 1547
Query: 2423 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP----ELEVVLTEDALKSLE 2478
++L E+ E +S+ S S+ +A++ L++DK E+E + + +S E
Sbjct: 1548 RDKLITEMDRSLLENQSL----SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE 1603
Query: 2479 NQTYFKSFEENGK---GSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEM 2535
Q K ++ + S N+ +++ V A E + Y +++ + + +
Sbjct: 1604 WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQ 1663
Query: 2536 LQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED 2595
LQ+ ++++ E+ A Q ++ ++E +N + +E + E
Sbjct: 1664 LQEAEQEMEEMKEKMRKFAKSKQQKILELEE------ENDRLRAEVHPAG-DTAKECMET 1716
Query: 2596 ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEK 2655
L S+ S ELE V+M + +K Q ++EK+ L +E + +L+ +EGN
Sbjct: 1717 LLSSNASMK----EELER--VKMEYETLSKKFQSLMSEKDSLSEEVQ--DLKHQIEGNVS 1768
Query: 2656 KQREKEK-KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEK 2714
KQ E ++ V + T+ E E ++L + T +E + A
Sbjct: 1769 KQANLEATEKHDNQTNVTEEGTQSIPGETE-----EQDSLSMSTRPTCSESVPSAKSANP 1823
Query: 2715 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKL 2774
+ + + + + Q+++ +A +E+ + ++ ++ E++K + + K
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ--KNKEFSQTLENEKNTLLSQISTK- 1880
Query: 2775 SKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL 2834
DG LK+ T ++NL ++ EE++ ++ K++E
Sbjct: 1881 --------DGELKMLQEEVT----------KMNLLNQQIQEELS--------RVTKLKET 1914
Query: 2835 HAAEILDMESRHISETETLK----------REHYVAVQLLKEECGTLKAVIQCLRSKEGS 2884
E D+E R +++ L + + +LL+ E LK + L ++
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 2885 SIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDS--FPKK 2942
+ E ++ +E G+ G + ++ E + E + D + +K
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
Query: 2943 IKGLLRAV------HNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKD 2996
I L R V E + L +T+ + +H + +E L K ++ S
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAE--LASFKVLLDDTQSEAA 2092
Query: 2997 LITKMQLQREAEVYDSSQSHESFSDWRGE----LLLALQQVFLEERSVL---LAAFRTEL 3049
+ L+ + E+ + +S +S + E L ++ L+E+ + L A R E
Sbjct: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREK 2152
Query: 3050 TALGTT--DAVGLLNCLEQRIQE----------QGVEYQAAMECLQKADRRSLLSEIQAL 3097
L T + LN ++ +Q+ Q + +M LQ DR ++ E +
Sbjct: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD-DRDRVIDEAKKW 2211
Query: 3098 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA----TELQEQ 3153
+ + + + E ++ + +L+ ++Q M E+++ +S ++ ++ Q +
Sbjct: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271
Query: 3154 LSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
+ ++ V L+ E + +LE T H EL E+K D++ L+++L
Sbjct: 2272 VQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC 2331
Query: 3214 QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3273
+++ L+ + +++A + S+ ++ DL+ S E + + ++N+ ++ LL+
Sbjct: 2332 KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGK 2391
Query: 3274 QQKIE----SQRMLYDAQ-------LSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3322
++ I+ R +D + LS+E+ N+ L+ + + ++ TL ++
Sbjct: 2392 EEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKE 2451
Query: 3323 HAQLQSS-DGTGQSRPPLPSE-DLLKELQKQLEEKHSRIV--------ELLNETEKYKLD 3372
+ Q ++ D +S L ++ D + +QLEE+H I+ E E K K +
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511
Query: 3373 SLQTRQQME----KDRQVHRKTLQTEQEAN------TEGQKKMHELQ----SKVEDLQRQ 3418
R M+ ++ ++ + +Q ++ N QK++ E+Q ++E+ +
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAK 2571
Query: 3419 LEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTR 3478
LEEK ++ + + + +R +QE +KQ+L +E ES ++ L T +L + T
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQE-EKQDLSKE--IESLKVSISQLTRQVT-ALQEEGTL 2627
Query: 3479 NWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCV----ASKLQVLPQKAS 3534
Q + KE +L + ELE ++L CV A K+ + K
Sbjct: 2628 GLYHAQL---KVKEEEVHRLSALFSSSQKRIAELE---EELVCVQKEAAKKVGEIEDKLK 2681
Query: 3535 ERL------------QFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCG 3582
+ L + ETA++ V E +++ QKL E L + S G
Sbjct: 2682 KELKHLHHDAGIMRNETETAEER----VAELARDLVEMEQKLLMVTKENKGLTAQIQSFG 2737
Query: 3583 SLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGA 3642
L + +L + + + +L+EQ R+ A ++ FS+N
Sbjct: 2738 RSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA-FSMN--- 2793
Query: 3643 NIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDS-LLQTLSPDSEHVTLKRI 3701
+ E S E N++ L+ + L +++ ++++ S + +L + +H+
Sbjct: 2794 STEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL----- 2848
Query: 3702 YGKYLRAESFRKA 3714
+ E FRK+
Sbjct: 2849 ---WNELEKFRKS 2858
Score = 187 bits (475), Expect = 2e-46
Identities = 454/2216 (20%), Positives = 888/2216 (40%), Gaps = 381/2216 (17%)
Query: 4 EERQKKLEAGKAKLAQFRQRKAQS-DGQSPSKKQKKKRKTSSSKHD-----VSAHHDLNI 57
+E+ K+ E +L Q + + +S DG+ PS Q++ ++ + HH +
Sbjct: 1220 DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279
Query: 58 DQSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSE 117
+S + + S+ + S EI + + VELE ++S+T + + +
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEK----VELELKVSSTTSELTKK 1335
Query: 118 VNGCSFVMRTGKPTNLLREEEFGVDDSYSEQG----------------AQDSPTHLEMME 161
EE F + + ++QG A+ LE +
Sbjct: 1336 -----------------SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQ 1378
Query: 162 SELAGKQHEIEELNRELEEMR--VTYGTEGLQ----QLQEFEAA-------IKQRDGIIT 208
++AG +H + EL +L+E++ ++ E + QL E EAA I +++ +I
Sbjct: 1379 LQIAGLEH-LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIK 1437
Query: 209 QLTANLQQARREKDETMREF-LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK 267
L L+ +E DE +++ +EL E QK + ++ +A + ++ ++ L ++
Sbjct: 1438 ALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAA-----LISR 1492
Query: 268 QQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK 327
++ L + L+E+ L + E T ++ ++ ++ E+D + + +E+
Sbjct: 1493 KEALKENKSLQEE---LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ-EER 1548
Query: 328 ETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL-ELTNSKQK 386
+ +I E++ ++E + + + L A + L E +E++V++ + +K+ K+ E T ++K
Sbjct: 1549 DKLITEMDRSLLENQSLSSSC-ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEK 1607
Query: 387 ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIV 446
++ +E + L+ + E + + Q + V++ +QE KL A E +Q+
Sbjct: 1608 HKELQKEYEILLQSYENVSNEAER-IQHVVEAVRQEKQELYGKLRSTEANKKET-EKQLQ 1665
Query: 447 QMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL-MNVAINELNIKLQDT 505
+ +QE MEEMK + + ++ + + D+++ ++ A + ++
Sbjct: 1666 EAEQE--------MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717
Query: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK-----LNE 560
S +KEEL + E L ++ + L+ E E++Q + I SK E
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777
Query: 561 AHKSLSTV-EDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619
H + + V E+ I +E + L + + E + K+A A S++
Sbjct: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCS------ESVPSAKSA---NPAVSKD 1828
Query: 620 AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679
SH+E + L++ +++ RI + + + Q ++ +N + +I
Sbjct: 1829 ----------FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS 1878
Query: 680 TMQFEKDNL---ITKQNQL-------ILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729
T E L +TK N L + ++KLK+ + + E + Q+ EL I
Sbjct: 1879 TKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI- 1937
Query: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLED 789
G Q+V + Q+K ELLE +MK +L++ ++LE E L EK
Sbjct: 1938 ---------GNYCQDVTDAQIKNELLESEMK----NLKKCVSELEEEKQQLVKEK----- 1979
Query: 790 MLKIHTPVSQEERLIFLDSIKSKSKD---SVWEKEIEILIEENE----DLKQQCIQLNEE 842
T V E R +L+ I+ K+ KE++ L++E + L++ CI+ E+
Sbjct: 1980 -----TKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
Query: 843 IEKQRNTFSFAE-------KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895
I T E K+ E+ + L + K + +L K + +
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094
Query: 896 LNEELHLQR---INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREK 952
L + L L++ N +VK + DED E E + EK + EKL+ +REK
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK--KNMQEKLDALRREK 2152
Query: 953 LELSQRLSDLSEQLKQKHGEISFLNE--------------EVKSLKQEKEQVSLRCRELE 998
+ L + + ++ L +K E+ L E + SL+ ++++V ++ E
Sbjct: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE 2212
Query: 999 IIIN---HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVS 1055
+ ++ E ++ + S L D + M+ E K+N S E K + E K
Sbjct: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEE---LKINISRLEHDKQIWESKAQ 2269
Query: 1056 FENMTVGEESKQEQLILDHLPSVTKE--SSLRATQ----PSEND--KLQKELNVLKSEQN 1107
E + +Q + D L KE S L T+ S+N+ KL+ EL LK +
Sbjct: 2270 -------TEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLT 2322
Query: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL 1167
DL +E C + ++ + + K E + A E L + +
Sbjct: 2323 DLSNSLEK---CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
Query: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
+ Q + + +G E + + + I +L++ +E L+ L S E + A DK
Sbjct: 2380 KEQKIISLLSGKE-EAIQVAIAELRQQHDKEIKE-LENLLSQEEEENIVLEEENKKAVDK 2437
Query: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287
N + E + ++ F ++M +L N L+ R I ++
Sbjct: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL 2497
Query: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHK--------SKLSSLQDLEKTKLEE- 1338
++ E N KEE L H N E+ ++ + +++ +++D ++ +L E
Sbjct: 2498 IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV 2557
Query: 1339 ---QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESD 1395
Q +ELE+ + L+++LKE+E+ E L++ A+ E S ++S+ ++ S
Sbjct: 2558 QLQQNKELENKYAKLEEKLKESEEANED----LRRSFNALQEEKQDLSKEIESLKVSISQ 2613
Query: 1396 AQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAF 1455
R + ++ G G+ VK EEEV ++ S +
Sbjct: 2614 LTRQV-----------TALQEEGTLGLYHAQLKVK----------EEEVHRLSALFSSSQ 2652
Query: 1456 AQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFK 1515
+ EL + A+ K V + E E+K G ET +E
Sbjct: 2653 KRIAELEEELVCVQKEAAKK----VGEIEDKLKKELKHLHHDAGIMRNETETA--EERVA 2706
Query: 1516 PLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMD 1575
L+++L E +++L+ E+K LT + F + S+SS+
Sbjct: 2707 ELARDLVEMEQKLLMVTK------ENKG--LTAQIQSFGR--------------SMSSLQ 2744
Query: 1576 ASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
SR NEE EL R+Y A ++++ Q ++Q L E L
Sbjct: 2745 NSRD-HANEE-----LDELKRKY-----------DASLKEL-AQLKEQGLLNRERDALLS 2786
Query: 1636 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV 1695
+ A + EN +S E++ + L +QL L +L +S Q Q+ ++ +
Sbjct: 2787 ETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL-----HLSSQLEDSYNQVQSFSKAMASL 2841
Query: 1696 E---EQTFKEKELDRK-----------PEDVPPEI--LSNERYALQKANNRLLKILLEVV 1739
+ + + E E RK P P E+ L +LQ +RLLK L +
Sbjct: 2842 QNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ 2901
Query: 1740 KTTAAVEETIGR-HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
+ + + I H L + + ++ A I + E S HE H
Sbjct: 2902 QQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELH----------- 2950
Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQ--AAVEK 1856
R + + W E+ +R ++ E+ ++ IS + Q + ++
Sbjct: 2951 ----QLRMEKSSW--------EIHERRMK------------EQYLMAISDKDQQLSHLQN 2986
Query: 1857 LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE-LRERLHEESRAREQLAV 1915
L+ + +SSQ + KV + +++L + E LR +L++ + Q +
Sbjct: 2987 LIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL 3046
Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
+ + +EK Q+ + + + +Q N LE + Q++Q
Sbjct: 3047 RIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQ----- 3101
Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
AGP+ ++V A + ++ + + K+ ++ E
Sbjct: 3102 -----------AGPL--------------NIDVAPGAPQEKNGVHR--KSDPEELREPQQ 3134
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091
F E +Q +L + RQ+ L K LE+ R +Q + E+ V +++I++LE
Sbjct: 3135 SFSEAQQ----QLCNTRQEVNELRKLLEEER----DQRVAAENALSVAEEQIRRLE 3182
Score = 121 bits (304), Expect = 1e-26
Identities = 230/1172 (19%), Positives = 497/1172 (42%), Gaps = 183/1172 (15%)
Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHH-DLNIDQS 60
+DE+ +++LE + K +++K + +++K + + + V+ + D + Q
Sbjct: 2119 KDEDLERRLEQAEEK--HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHS---------GEITSHEQGFSVELES---EIS 108
Q N ++STV + +++ S E E+ FS ++S EI
Sbjct: 2177 QEN---------LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
Query: 109 TTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQ----DSPTHLEMMESEL 164
D+CS V++ + EE ++ S E Q + T +++ +
Sbjct: 2228 LKEDNCS--------VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVC 2279
Query: 165 AGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDET 224
Q E +EL +LEE R Y + +L + E+ +K +T L+ +L++ + +K
Sbjct: 2280 DTLQGENKELLSQLEETRHLYHSSQ-NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL 2338
Query: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT--HQQQLEEQDH 282
+ Q + ++QL+ LQA +++ + H++ ++
Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETD---------------LQASRELTSRLHEEINMKEQK 2383
Query: 283 LLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEE 342
++ K+E + I+ L+++ ++ K++EN +E +E+ ++EE N K ++
Sbjct: 2384 IISLLSGKEEAIQVAIAELRQQ----HDKEIKELENLLSQE-EEENIVLEEENKKAVD-- 2436
Query: 343 KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVE 402
KT +L + L T K E +Q Q + +K+M +S Q +R +++G +
Sbjct: 2437 -KTNQLMETLKTIKK---ENIQQKAQLDSFVKSM-----SSLQNDRD------RIVGDYQ 2481
Query: 403 ELQKRNHKDSQFETDIVQRMEQETQRKLEQ---LRAELDEMYGQ------QIVQMKQELI 453
+L++R+ + ++Q E + E+ LR+ +D++ + +++Q +++L
Sbjct: 2482 QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541
Query: 454 R------QHMAQMEEMKTRHKGEMENA-LRSYSNITVNEDQIKLMNVAINELNIKLQDTN 506
+ Q+ E++ + E+EN + + +E+ + + + N L + QD +
Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601
Query: 507 SQKEKLKEELGLILEEKCALQRQ--LEDLVEELSFSREQIQRARQTIAEQESKLNEAHKS 564
+ E LK + + + ALQ + L +L E++ R + + ++ E +
Sbjct: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661
Query: 565 LSTVEDLKAEIVSASESRKELELKH----------EAEVTNYKI------------KLEM 602
L V+ A+ V E + + ELKH E E ++ KL M
Sbjct: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721
Query: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEE--ELSK-----LKEDLEIEHRINIEKL 655
+ KE N L +S + L+ ++EE EL + LKE +++ + + +
Sbjct: 2722 VTKE-NKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE 2780
Query: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715
+D L ++ + +E + L++K QL+ S+L+D + V S S+
Sbjct: 2781 RDALLSETAFSMNSTEENSLSHLEKL---NQQLLSKDEQLLHLSSQLED-SYNQVQSFSK 2836
Query: 716 EMTLQINE---LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQ 772
M NE L E+E R+ E+ K + + + L+K M +ND
Sbjct: 2837 AMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND------- 2889
Query: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 832
+ +LK+ K + L+I+ +++ L +K++ ++ ++ + + E+L
Sbjct: 2890 ---RDRLLKELKNLQQQYLQINQEITE------LHPLKAQLQE--YQDKTKAFQIMQEEL 2938
Query: 833 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLEDSKNK-QELEYK 890
+Q+ + E+ + R + ++E++ + ++E+Y + KD L +N +EL
Sbjct: 2939 RQENLSWQHELHQLR----MEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS 2994
Query: 891 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
S + + ++ +P T S+ D + V ET E T+L + L+ +
Sbjct: 2995 SSQTQPLKVQYQRQASPET----SASPDGSQNLVYET-------ELLRTQLNDSLKEIHQ 3043
Query: 951 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 1010
++L + Q S+ S+ L++K+ L + +SL++ ++ ++NH Q
Sbjct: 3044 KELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG-------DLLNHCAVLEKQ 3096
Query: 1011 SCDTQVSSLLDGVVTMTSRGAEG--------SVSKVNKSFGEESKIMVEDKVSFENM-TV 1061
+ Q L V + G + + +SF E + + + + +
Sbjct: 3097 VQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKL 3156
Query: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSEND 1093
EE + +++ ++ SV +E +R + SE D
Sbjct: 3157 LEEERDQRVAAENALSVAEE-QIRRLEHSEWD 3187
Score = 75.1 bits (183), Expect = 1e-12
Identities = 119/591 (20%), Positives = 239/591 (40%), Gaps = 64/591 (10%)
Query: 3123 EYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQ 3182
+ N++ L + ++ ++QE+L+ + +V ELK + Q ++L+ +A
Sbjct: 23 DQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL 82
Query: 3183 HKHLK----ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD 3238
+ K +++ +L K K ++ + + ++ + E++ +K +S +
Sbjct: 83 QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142
Query: 3239 KEELEDLKFSLESQKQ--RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3296
+ E+E +K L+ +++ LQ L Q +Q S + E M Q EE L
Sbjct: 143 EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202
Query: 3297 ELQV----LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL 3352
+ Q+ ++ + +RE + + + LH + Q+ + L+ LQ++L
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHED-ELLQLVTQADVETEMQQKLRVLQRKL 261
Query: 3353 EEK------HSRIVELLNE----TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN---- 3398
EE +++V+LL + E+ Q QQME + R T++TE+E +
Sbjct: 262 EEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321
Query: 3399 -------TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451
E + H LQ ++ L Q E+ Q +L+ L+ QK + E E
Sbjct: 322 EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE------QKHKAEME 375
Query: 3452 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHE 3511
EK L + E + + +LQ K E + + + +E
Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE----------- 424
Query: 3512 LEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQK-LTGQQGE 3570
+ ++QK + ++ L LP + E + D Q +E I LQK + + E
Sbjct: 425 -DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE 483
Query: 3571 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGR 3630
+ +L+ S E L +N +L+ I+ L + +N + + ++
Sbjct: 484 KGALLLSSIE----LEELKAENEKLSSQITLL-----EAQNRTGEADREVSEISIVDIAN 534
Query: 3631 DNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELR 3681
SS +G +E + + ++E L +K A+ E+ LK +L+
Sbjct: 535 KRSSSAEESGQDVLENTFSQK----HKELSVLLLEMKEAQEEIAFLKLQLQ 581
Score = 33.9 bits (76), Expect = 3.3
Identities = 64/324 (19%), Positives = 124/324 (38%), Gaps = 56/324 (17%)
Query: 3364 NETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKR 3423
++T++ L E D + + T + QE ++ + EL+ + QL++K
Sbjct: 20 DDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQK- 78
Query: 3424 QQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQ 3483
+ L+ E K +I L+ LTS ++ +
Sbjct: 79 ---------------------DEALQEERKAADNKIKKLKLHAKA--KLTS--LNKYIEE 113
Query: 3484 QKIEG----ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ----CVASKLQVLPQKASE 3535
K +G T+ + +L + + T E+E I+ KLQ +++ L Q +E
Sbjct: 114 MKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAE 173
Query: 3536 RLQFETADDEDFIWVQENI---DEIILQLQ-KLTGQQGEEPSLVSPSTSCGSLTERLLRQ 3591
+ + + E+F+ +++ + +E I LQ +L+ Q E+ + ++
Sbjct: 174 QPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLH 233
Query: 3592 NAELTGHISQL---TEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAII 3648
EL ++Q TE + LR + KLEE SL G A + ++
Sbjct: 234 EDELLQLVTQADVETEMQQKLRVLQRKLEEH---------------EESLVGRAQVVDLL 278
Query: 3649 ASEKEVWNREKLTLQKSLKRAEAE 3672
E + L + L++ EAE
Sbjct: 279 QQELTAAEQRNQILSQQLQQMEAE 302
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 285 bits (728), Expect = 8e-76
Identities = 613/3005 (20%), Positives = 1254/3005 (41%), Gaps = 421/3005 (14%)
Query: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFL 229
E+EE R E++ + Q L + A + RD Q ++++ ++EK +
Sbjct: 174 EVEERKRLEAEVKALQAKKASQTLPQ--ATMNHRDIARHQASSSVFSWQQEKTPS----- 226
Query: 230 ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQK 289
L+ SQ+ I+ + AS + + + L K+ + HLL+ +
Sbjct: 227 HLSSNSQRTPIR-RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285
Query: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK 349
+ ++ +I+ L+ +++ +E E +V + QE + +E+ ++IE+EK + +
Sbjct: 286 QNQELRNKINELELRLQGHEKEMKGQVN-----KFQELQLQLEKAKVELIEKEKVLNKCR 340
Query: 350 DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409
D+L + + Q++K +LT +RQ++E + ++E+ K
Sbjct: 341 DELVRTTAQYDQASTKYTALEQKLK----KLTEDLSCQRQNAESARC---SLEQKIKEKE 393
Query: 410 KDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKG 469
K+ Q E QR Q ++ Q++A L Q +Q + + A+++++ T K
Sbjct: 394 KEFQEELSRQQRSFQTLDQECIQMKARLT-----QELQQAKNMHNVLQAELDKL-TSVKQ 447
Query: 470 EMENALRSYSNITVNEDQ-IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
++EN L + +Q + + NEL +++ + LK E C L+
Sbjct: 448 QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507
Query: 529 QLEDLVEELSFSREQIQRARQTIAEQES-------KLNEAHKSLSTVEDLKAEIVSASES 581
+L+++ + L+ S+ + + QE+ K+N+ SL T+E LK + +
Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL-TLEKLKLAVADLEKQ 566
Query: 582 R---KELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ-LLFS-HEEE 636
R ++L K E + KL EKE A+L + E ++ E E L+ + LFS + E
Sbjct: 567 RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL-ELKKKEYEELKEEKTLFSCWKSE 625
Query: 637 LSKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLITKQNQL 695
KL +E E + N++ ++L K QQI +E ++++ T++ +++NL + L
Sbjct: 626 NEKLLTQMESE-KENLQSKINHLETCLKTQQIK--SHEYNERVRTLEMDRENLSVEIRNL 682
Query: 696 ILEISKLKDLQQSLVNSKSEEMTLQ---INELQKEIEILRQEEKEK--------GTLEQE 744
++++SKS E+ Q ELQ++ E Q+ +++ L +
Sbjct: 683 -----------HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
Query: 745 VQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL---EDMLKIHTPVSQEE 801
V++L+ K +LL ++ +K+ Q+ A+ E+ +LK + +L ED + Q+
Sbjct: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQP 791
Query: 802 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
+ + + S+ + E +E ++ K I ++ + ++ F+ ++ +
Sbjct: 792 AMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMN 846
Query: 862 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921
+LQ++ L+++K ++E++ K E ++S + + QRI+ K++ +
Sbjct: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS-----QRIS----KLQEDT-SAHQ 896
Query: 922 TFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVK 981
VAETL E EK+ L +K+E + E EL + L + LK E+ L+E +
Sbjct: 897 NVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK----ELQLLSETLS 952
Query: 982 SLKQEKEQ-VSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGVVTMTS--RGAEGSVS 1036
K+E +SL RE+E + N E S + + +L+ + + E S+S
Sbjct: 953 LEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS 1012
Query: 1037 KVNKSFGEESKIMVE---------DKVSFENMTVGEESKQEQLILDHLPSVTKE-----S 1082
+++ + +E I+++ + +S + E++ + + +L+ S+ +
Sbjct: 1013 ELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELE 1072
Query: 1083 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142
L+ E+ + +L + +L L++E + L ++ + N K +A
Sbjct: 1073 QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR-------SEMTDNQNNSKSEA 1125
Query: 1143 LCSLKEELIFAQEEK---IKELQKIHQLELQTMKTQETGD-----EGKPLHLLIGKLQKA 1194
LK+E++ +EE+ KE+ + Q Q MK +T E +P+ + K +++
Sbjct: 1126 -GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV-KERES 1183
Query: 1195 VSEECSYFLQTLCSV----LGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQ 1250
+C++ Q V L Y ++ E +KE + + E + ++E+Q
Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELK----LQESEKEKECLQHELQ 1239
Query: 1251 DFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQ 1310
+ ++ T + L + Q+ G+K + + EE H
Sbjct: 1240 TIRGDLET----------------SNLQDMQSQEISGLK----DCEIDAEEKYISGPHEL 1279
Query: 1311 MTNLED---IDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHC 1367
T+ D + + ++ ++ L +LEK Q ++ E L++ L E I
Sbjct: 1280 STSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYE-LVTELNDSRSEC-------ITA 1331
Query: 1368 LQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETN 1427
+K + V + ++ V I D+ + G V+ G EF + + +
Sbjct: 1332 TRKMAEEVGKL-------LNEVKILNDDS--GLLHGELVEDIPGG--EFGEQPNEQHPVS 1380
Query: 1428 IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHY 1487
+ L E E L ++ V M A Q+ L S Q+ +QH
Sbjct: 1381 LAPLDESNSYEHL--TLSDKEVQMHFAELQEKFL------------SLQSEHKILHDQHC 1426
Query: 1488 FNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLT 1547
K+S+ Q + + ++ + G+ KE+ L + S CV
Sbjct: 1427 QMSSKMSELQTYVDSLKAENLVLSTNLRNFQ---GDLVKEMQLGLEEGLVPSLSSSCVPD 1483
Query: 1548 ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATEL 1607
S D +F +++ ++ S+ ++ + ++ Q + + QE +
Sbjct: 1484 SSSLSSLGDSSFY--RALLEQTGDMSLLSNLEGAVSANQC-SVDEVFCSSLQEENLTRKE 1540
Query: 1608 LRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS 1667
A + +E E ++ +++L ++ + + N +E++ L+QL
Sbjct: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKN------------KEIQELEQLL 1588
Query: 1668 LAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA 1727
+ R++L C + Q +EN+ ++ T E++ K A +K
Sbjct: 1589 SSERQELDC------LRKQYLSENEQWQQKLTSVTLEMESK-------------LAAEKK 1629
Query: 1728 NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSC-VHEE 1786
L + LEV + + R +LGI + ++ R+E SC + +E
Sbjct: 1630 QTEQLSLELEVARLQLQGLDLSSRSLLGI-------DTEDAIQGRNE------SCDISKE 1676
Query: 1787 HTRVTDESIPSYSGSDM----PRNDINM-WSKVTEEGTELSQRLVRSGFAGTEIDPENEE 1841
HT T E P + + + D+N+ K+TE G + +G E P+
Sbjct: 1677 HTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGA-----VKPTGECSGEQSPDT-- 1729
Query: 1842 LMLNISSRLQAAVEKLLEAISETSSQLEHAKV------TQTELMRESFRQKQEATESLKC 1895
N + + E ISE S +A V Q ++ R K+ + E+L+
Sbjct: 1730 ---NYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRL 1786
Query: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
+ +R R E L E+ + + + L E Q+ K + LE+
Sbjct: 1787 LHVIEDR----DRKVESLLNEMKELDSKLH-------LQEVQLMTKIEACIELEK----- 1830
Query: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK- 2014
+ EL+ E + E+ E S Q+LLQ E +++ A+K
Sbjct: 1831 --IVGELKKENSDLSEKLEYFSCD-----------HQELLQRVETSEGLNSDLEMHADKS 1877
Query: 2015 VRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ---LEKMRKFLDE 2071
R+D+ V + +E RF+++E EL +R + ++E + LE + +
Sbjct: 1878 SREDIGDNVAKVNDSWKE---RFLDVE----NELSRIRSEKASIEHEALYLEADLEVVQT 1930
Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVV--PRFQPISE-----HQTREVEQLANHLKEKTDK 2124
+ + E + + Q+ I LE++L VV R Q E +T ++QL+ +KEKT +
Sbjct: 1931 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1990
Query: 2125 C----SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVE 2180
SE L + + +++E+ E ++ L V EL L +K++ +
Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSEL---LKDKTHLQEKLQSLEKDSQAL 2047
Query: 2181 AKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE---IQK 2237
+ + LE Q+ A KEKE+ L ++ E + L + E + LE ++K
Sbjct: 2048 SLTKCELENQI-----AQLNKEKEL--LVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
E RL ++E + +EKL + I +A + H+ A+ ++E+E E D L
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRI---EADEKKQLHI-----AEKLKERERENDSL 2152
Query: 2298 NEQVTKLQQQLKITTDNKVI-----EEKNELIRDLETQIECLMSDQECVKRN---REEEI 2349
++V L+++L+++ +N+ + E + L+TQIE + + + + E
Sbjct: 2153 KDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK 2212
Query: 2350 EQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-----ALEQQVET 2404
E L + I++ Q +L+ + K + SL EE K Q ++ I E+ L+ Q++
Sbjct: 2213 ENLTKQIQEKQGQLSEL-DKLLSSFKSLLEE----KEQAEIQIKEESKTAVEMLQNQLKE 2267
Query: 2405 ANEEMTFM---KNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2461
NE + + + ++K T ++ +E L+ E + E + L +
Sbjct: 2268 LNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKES 2327
Query: 2462 KPELEVV--LTEDALKSLE----NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLEL 2515
+ +++ E+ + LE NQ + EN KG + L+ ++ + ++ +L++
Sbjct: 2328 EHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDV 2387
Query: 2516 TQCYKQIKDMQEQGQFETEMLQK-KIVN------LQKIVEEKVAAALVSQIQLEAVQEYA 2568
+ +++ + Q E E + + +I+N LQ+ +EKV S +E +Q
Sbjct: 2388 VTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL 2447
Query: 2569 KFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQ 2628
K + N+ +++ N Q + +E L S + L L ++L + E + I+ +
Sbjct: 2448 K--ELNERVAA---LHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502
Query: 2629 VEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK-KRSPQDVEVLKTTTELFHSNEESGF 2687
V + V + ++KL EKK E + K QD E L + +
Sbjct: 2503 VNGLIQEVEDGKQKL----------EKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2552
Query: 2688 FNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVR-DHLAEAKEK 2746
LE LR +V + ++ + K LQ+ L V +++ +L+ +L + D ++ ++
Sbjct: 2553 EQNLE-LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKV 2611
Query: 2747 LSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI------SSSNQTPQILVK 2800
+ KE E + + + A L +LS ++ G L++ SS +Q ++ ++
Sbjct: 2612 NKMTAKETELQREMHEMAQKTAELQEELSGE-KNRLAGELQLLLEEIKSSKDQLKELTLE 2670
Query: 2801 NAGIQINLQSECSSE-----EVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKR 2855
N+ ++ +L + +V E I+++ ++ + ++ H A +LD ++ E +T +
Sbjct: 2671 NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730
Query: 2856 EHYVAVQLLKEEC-GTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIY 2914
+ KEEC + K I L+S + E ++ T +I + Y
Sbjct: 2731 K-----LTSKEECLSSQKLEIDLLKSSK-----EELNNSLKATTQILEELKKTKMDNLKY 2780
Query: 2915 LTHSQGFDIASEGR-------GEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSD 2967
+ + + ++G+ ++ E + K++ L A + + T+
Sbjct: 2781 VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELT 2840
Query: 2968 GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSH----ESFSDWR 3023
E +++ E +E Y++ SL LI+ +L++ E+ ++ +H +S D R
Sbjct: 2841 TEIKELKETLEEKTKEADEYLDKYCSL--LISHEKLEKAKEMLETQVAHLCSQQSKQDSR 2898
Query: 3024 GELLL 3028
G LL
Sbjct: 2899 GSPLL 2903
Score = 213 bits (542), Expect = 3e-54
Identities = 612/3148 (19%), Positives = 1248/3148 (39%), Gaps = 533/3148 (16%)
Query: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ---TIAEQESK 557
K+Q+ Q +KLK+E K Q QL+ L L +++++ + + + +
Sbjct: 19 KIQELEGQLDKLKKE-------KQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQR 71
Query: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM--- 614
L E +SL + + + ES+ + E ++ + K ++E LE+E +
Sbjct: 72 LMEICESLEKTKQKISHELQVKESQVNFQ---EGQLNSGKKQIEKLEQELKRCKSELERS 128
Query: 615 ---AESQEAELERLRT-QLLFS-------------HEEELSKLKEDLEIEHRINIE---- 653
A+S + L T Q +F+ +E+ K +++E R+ E
Sbjct: 129 QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKAL 188
Query: 654 ---KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710
K L D +++ S + + Q EK N I + D S
Sbjct: 189 QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR--DFSASYF 246
Query: 711 NSKSE----EMTLQINELQKEIE---------ILRQEEKEKGTLEQEVQELQLKTELLEK 757
+ + E TLQI + +L Q + + L ++ EL+L+ + EK
Sbjct: 247 SGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEK 306
Query: 758 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK--IHTPVSQEERLIFLDSIKSKSKD 815
+MK + N QE QLE L +++K L + T ++ +++ K K
Sbjct: 307 EMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLK- 365
Query: 816 SVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL-LKV 874
K E L + ++ + L ++I+++ F + ++Q L +E + ++
Sbjct: 366 ----KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARL 421
Query: 875 KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV- 933
+L+ +KN + +++L L Q++ + K + ++ F A ++ E+
Sbjct: 422 TQELQQAKNMHNV-LQAELDKLTSVK--QQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
Query: 934 -----VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKE 988
++K+ L E RE L L ++ + L Q EE+K+ K +
Sbjct: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN----FAEEMKA-KNTSQ 533
Query: 989 QVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE--S 1046
+ LR + +I N+ EN + + ++ D R + K + E+
Sbjct: 534 ETMLRDLQEKI----NQQENSLTLEKLKLAVAD---LEKQRDCSQDLLKKREHHIEQLND 586
Query: 1047 KIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQ 1106
K+ +K S ++ E K+E + +E +L + SEN+KL L ++SE+
Sbjct: 587 KLSKTEKESKALLSALELKKKEY------EELKEEKTLFSCWKSENEKL---LTQMESEK 637
Query: 1107 NDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEEL---------IFAQEEK 1157
+L+ ++ CL Q++ + NE+ + L +E L + +
Sbjct: 638 ENLQSKINHLETCLK------TQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV 691
Query: 1158 IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPA 1217
E QK+ +ELQ + E D+ K QK + C Q V
Sbjct: 692 EVETQKLAYMELQ--QKAEFSDQ---------KHQKEIENMCLKTSQLTGQV-------- 732
Query: 1218 LKCEVNAEDKENSGDYISE---NEDPELQDYRYEVQDFQENMHTL-LNKVTEE------- 1266
ED E+ +S ++D QD E + ++ + + + VT E
Sbjct: 733 -------EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLL 785
Query: 1267 -YNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKL 1325
+++ + + I G+Q M E E L +++ S Q ++ ++ + +S+
Sbjct: 786 AFDQQPAMHHSFANIIGEQ-GSMPSERSECRLEADQSPKNSAILQ-NRVDSLEFSLESQK 843
Query: 1326 SSLQDLEKT---------KLEEQVQELE----SLISSLQQQLKETEQNYEAEIHCLQKRL 1372
DL+K ++EE + + E S ++ Q++ + +++ A + + + L
Sbjct: 844 QMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETL 903
Query: 1373 QAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGV--KEETNIVK 1430
A+ L D V +++ Q ++ ++ S + KE ++I+
Sbjct: 904 SALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIIS 963
Query: 1431 LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNE 1490
L +++ +E +E ++ S+ ++ L + S N ++ +Q+ +
Sbjct: 964 LNKREIEELTQENGTLKEINASLN-QEKMNLIQKSESFANYIDEREKSISELSDQYKQEK 1022
Query: 1491 MKLSQ--DQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTI 1548
+ L Q ++ G +E + K+K + SK E LL+ + E++ L
Sbjct: 1023 LILLQRCEETG-NAYEDLSQKYKAAQEKNSK------LECLLNECT--SLCENRKNELEQ 1073
Query: 1549 SEEMFSKD-KTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATEL 1607
+E F+K+ + F+ + + +E ++ LML +LE ++Q L + ++Q ++
Sbjct: 1074 LKEAFAKEHQEFLTKLAFAEE-------RNQNLML---ELETVQQALRSEMTDNQNNSKS 1123
Query: 1608 LRQAHMRQMERQREDQEQLQEEIKRL---NRQLAQ--RSSIDNENLVSERERVLLEELEA 1662
+++ +E+Q ++Q+E+ L N QL + ++ + +NL SE R ++E E+
Sbjct: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES 1183
Query: 1663 LKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERY 1722
+ + ++ E++ S + N Q E + KEL + + E L +E
Sbjct: 1184 ERN-QCNFKPQMDLEVKEISLDSYNAQLVQLEA---MLRNKELKLQESEKEKECLQHE-- 1237
Query: 1723 ALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSC 1782
LQ L T+ +++ + + G+ D +AE S
Sbjct: 1238 -LQTIRGDL---------ETSNLQDMQSQEISGLKD------------CEIDAEEKYISG 1275
Query: 1783 VHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL 1842
HE T D + S N +N K+ E LV TE++ E
Sbjct: 1276 PHELSTSQNDNAHLQCS-LQTTMNKLNELEKICEILQAEKYELV------TELNDSRSEC 1328
Query: 1843 MLNISSRLQAAVEKLLEAIS--ETSSQLEHAKVTQTELMRESFRQKQEATE-SLKCQEEL 1899
+ + ++ V KLL + S L H ++ + E Q E SL +E
Sbjct: 1329 -ITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDES 1387
Query: 1900 RERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ------EKTDIIDRLEQELL 1953
H +E E + ++ K L ++ Q E +D L+ E L
Sbjct: 1388 NSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENL 1447
Query: 1954 CASNRLQELEAE---QQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010
S L+ + + + Q+ E L+ ++ + P L + L Q
Sbjct: 1448 VLSTNLRNFQGDLVKEMQLGLEEGLVP----SLSSSCVPDSSSLSSLGDSSFYRALLEQT 1503
Query: 2011 QAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTE--------LMDLRQQNQALEKQL 2062
+ +L+ V A + V+E ++ E E + +L + + L
Sbjct: 1504 GDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSL 1563
Query: 2063 EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ---------TREVEQ 2113
EK+ + ++ Q I + E +Q + Q+L + R Q +SE++ T E+E
Sbjct: 1564 EKLEEKMESQGIMKNKEIQELEQLLSSERQELDCL-RKQYLSENEQWQQKLTSVTLEMES 1622
Query: 2114 LANHLKEKTDKCS-ELLLSKEQLQR-DIQERNEEIEKLEFRVRELEQALLVSADTFQKVE 2171
K++T++ S EL +++ QLQ D+ R+ E ++ ++ +S + +
Sbjct: 1623 KLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETT 1682
Query: 2172 DR--KH----FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEE 2225
+R KH +A+ +L+L+++ E A+ + E + + + E+K +
Sbjct: 1683 ERTPKHDVHQICDKDAQQDLNLDIEKITETGAV-KPTGECSGEQSPDTNYEPPGEDKTQG 1741
Query: 2226 VQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG---K 2282
+ +L + + L + +D+ L L +KE+ + + HV+ K
Sbjct: 1742 SSECISELSFSGPNALVPMDFLGNQ-----EDIHNLQLRVKETSNENLRLLHVIEDRDRK 1796
Query: 2283 FAQIIQEKEVEIDQLNEQVTKLQQQLK-----------ITTDNKVIEEK--------NEL 2323
++ E + +L+ Q +L +++ + +N + EK EL
Sbjct: 1797 VESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQEL 1856
Query: 2324 IRDLETQIECLMSDQE--CVKRNREEEIEQLNEVIEKLQQELANIGQKTSM---NAHSLS 2378
++ +ET E L SD E K +RE+ + + +V + ++ ++ + S S+
Sbjct: 1857 LQRVETS-EGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIE 1915
Query: 2379 EEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE 2438
EA L+ L+VV EKL LE+ E + + ++ L + NQL EL ++ ++
Sbjct: 1916 HEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTT 1975
Query: 2439 SVEKIQSIPENSVNVAIDHLS-------------KDKPELEVVLTEDALKSLENQTYFKS 2485
+++++ + H S K+K EL L+ D + L+++T+
Sbjct: 1976 ALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTH--- 2032
Query: 2486 FEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQK 2545
L+ +L LE A L LT+C ++++ Q E E+L K+ +LQ
Sbjct: 2033 -----------LQEKLQSLEKDSQA--LSLTKC--ELENQIAQLNKEKELLVKESESLQA 2077
Query: 2546 IVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALT 2605
+ E S+ E+ N+ + E G
Sbjct: 2078 RLSE-----------------------------SDYEKLNVSKALEAALVEKGE----FA 2104
Query: 2606 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2665
LR+S + +V ++ + + ++E EK L +KL K+RE+E
Sbjct: 2105 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKL------------KERERENDSL 2152
Query: 2666 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN 2725
VE L+ ++ N+E L L AE+ +KAE+ + K + E++ L V E +
Sbjct: 2153 KDKVENLERELQMSEENQE------LVILDAEN--SKAEVETLKTQIEEMARSLKVFELD 2204
Query: 2726 MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGT 2785
+ +L+ + + + E + +LS L+K + S K+ + E ++ S+T
Sbjct: 2205 LVTLRSEKENLTKQIQEKQGQLSELDK-----LLSSFKSLLEEKEQAEIQIKEESKTAVE 2259
Query: 2786 LKISSSNQTPQILVKNAGIQ-INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMES 2844
+ + + + + G Q I +E S + E Q IEK++ A+ E
Sbjct: 2260 MLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD----EK 2315
Query: 2845 RHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSD 2904
+ + + LK + A LLK L+ ++ R+ + + E
Sbjct: 2316 KQLCVLQQLKESEHHA-DLLKGRVENLERELEIARTNQEHAALE---------------- 2358
Query: 2905 SGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESP 2964
E S+ ++ KI+G+ +++ + V+++
Sbjct: 2359 ------------------------AENSKGEVETLKAKIEGMTQSLRGLELDVVTIR--- 2391
Query: 2965 YSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRG 3024
S+ E+ + + E +ER + + I+S + I + + Q + ++ + S +
Sbjct: 2392 -SEKENLTNELQKE---QERISELEIINSSFENILQEKEQEKVQMKEKSST--------- 2438
Query: 3025 ELLLALQQVFLEERSVLLAAFRTELTALGTTDA--VGLLNCLEQRIQE--QGVEYQAAME 3080
+ + Q L+E + +AA + A + + CLE + QG++
Sbjct: 2439 --AMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNY 2496
Query: 3081 CLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVEL 3140
+ ++ L+ E++ +G++ K+++E + ++ + +Q S++ +++ E
Sbjct: 2497 IVLQSSVNGLIQEVE------DGKQKLEKKDEEISRLKNQIQDQ--EQLVSKLSQVEGEH 2548
Query: 3141 SSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLK-ELEAFRLEVKDK 3199
K++ EL+ + + L+S+ A + LE L++ +K+L+ ELE ++ DK
Sbjct: 2549 QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEV-LQSSYKNLENELELTKM---DK 2604
Query: 3200 TDEVHLLNDTLASEQK----------KSRELQWALEKEKAKLGRSEERDKEELEDLKFSL 3249
V +N A E + K+ ELQ L EK +L + EE++ K L
Sbjct: 2605 MSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQL 2664
Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
+ N +L L+ + E + K+ + Y +L E + ++ Q LL
Sbjct: 2665 KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKH---QALL------- 2714
Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSE-----DLLKELQKQLEEKHSRIVELLN 3364
LD ++ ++Q+ S+ S DLLK +++L ++L
Sbjct: 2715 ------LDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE 2768
Query: 3365 ETEKYKLDSL---------------------QTRQQMEKDRQVHRKTL------QTEQEA 3397
E +K K+D+L ++ +Q+E+++++ +K L Q +Q+
Sbjct: 2769 ELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKT 2828
Query: 3398 NTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
T K+ EL +++++L+ LEEK ++
Sbjct: 2829 GTVMDTKVDELTTEIKELKETLEEKTKE 2856
Score = 205 bits (522), Expect = 6e-52
Identities = 458/2333 (19%), Positives = 959/2333 (41%), Gaps = 416/2333 (17%)
Query: 145 YSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD 204
+S + + + L+ EL + EIEE + E+M ++ E Q++ + +
Sbjct: 837 FSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQ 896
Query: 205 GIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLL 264
++ + + L+ +E + + + +E TEQ++
Sbjct: 897 NVVAETLSALENKEKEL-QLLNDKVE-TEQAE---------------------------- 926
Query: 265 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324
Q+L++ +HLLED K ++ L E + + E ++ + + NK EI
Sbjct: 927 ---------IQELKKSNHLLEDSLK-------ELQLLSETLSL-EKKEMSSIISLNKREI 969
Query: 325 QE---KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381
+E + ++E+N + +E+ + L K + + E ++ I + + + K KL L
Sbjct: 970 EELTQENGTLKEINASLNQEK---MNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
++ + E++ Q +K +Q + ++ + E E + EL+++
Sbjct: 1027 QRCEETGNAYEDLSQ-----------KYKAAQEKNSKLECLLNECTSLCENRKNELEQL- 1074
Query: 442 GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY-SNITVNEDQIKLMNVAINELNI 500
+ + QE + + +A EE E+E ++ S +T N++ K L
Sbjct: 1075 KEAFAKEHQEFLTK-LAFAEERNQNLMLELETVQQALRSEMTDNQNNSK---SEAGGLKQ 1130
Query: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
++ ++ K+++E+ +L+E L + ++ E + E I R ++ E+ES+ N+
Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPI---RNSVKERESERNQ 1187
Query: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620
+ DL+ + +S +L ++ EA + N ++KL+ EKEK L ++
Sbjct: 1188 C--NFKPQMDLEVKEISLDSYNAQL-VQLEAMLRNKELKLQESEKEKEC-LQHELQTIRG 1243
Query: 621 ELERLRTQLLFSHEEELSKLKEDLEIE---------HRINIEKLKDNLGIHYKQQID-GL 670
+LE Q + S +E+S LK D EI+ H ++ + DN + Q
Sbjct: 1244 DLETSNLQDMQS--QEISGLK-DCEIDAEEKYISGPHELSTSQ-NDNAHLQCSLQTTMNK 1299
Query: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
NE+ + E +Q EK L+T+ N +S + + +M ++ +L E++I
Sbjct: 1300 LNELEKICEILQAEKYELVTELND-----------SRSECITATRKMAEEVGKLLNEVKI 1348
Query: 731 LRQEE-------------KEKGTLEQEVQELQL----------KTELLEKQMKEKENDLQ 767
L + E G E + L L +K+++ +LQ
Sbjct: 1349 LNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQ 1408
Query: 768 EKFAQLEAENSILKDEKKTLED-MLKIHTPVS--QEERLIFLDSIKSKSKDSVWEKEIEI 824
EKF L++E+ IL D+ + M ++ T V + E L+ ++++ D V KE+++
Sbjct: 1409 EKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLV--KEMQL 1466
Query: 825 LIEEN--EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882
+EE L C+ + + S + +F Y+ L E+ + + +LE +
Sbjct: 1467 GLEEGLVPSLSSSCVPDSSSLS------SLGDSSF---YRALLEQTGD-MSLLSNLEGAV 1516
Query: 883 NKQELEYKSKLKALNEELHLQRINPTTVKMKS--------SVFDEDKTFVAETLEMGEVV 934
+ + + +E +L R + K V+ + + E +E ++
Sbjct: 1517 SANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIM 1576
Query: 935 EKDTTELMEKLEVTKREKLE-LSQRLSDLSEQLKQKHGEISF-LNEEVKSLKQEKEQVSL 992
+ + +E+L ++R++L+ L ++ +EQ +QK ++ + ++ + K++ EQ+SL
Sbjct: 1577 KNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSL 1636
Query: 993 RCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052
ELE+ +Q D SLL G+ T + ++K E+ E
Sbjct: 1637 ---ELEV-----ARLQLQGLDLSSRSLL-GIDTEDAIQGRNESCDISKEHTSET---TER 1684
Query: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT-------------QPSENDKLQKEL 1099
+ + ++ Q+ L LD + +T+ +++ T +P DK Q
Sbjct: 1685 TPKHDVHQICDKDAQQDLNLD-IEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSS 1743
Query: 1100 NVLKS----------EQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEE 1149
+ + L Q + + L + +++ + ++ ++D+ + SL E
Sbjct: 1744 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNE 1803
Query: 1150 LIFAQEEKIKEL-QKIHQLELQTMKTQETGDEGKPLHLLIGKLQKA---VSEECSYFLQT 1205
+ KEL K+H E+Q M E E L ++G+L+K +SE+ YF
Sbjct: 1804 M--------KELDSKLHLQEVQLMTKIEACIE---LEKIVGELKKENSDLSEKLEYFSCD 1852
Query: 1206 LCSVL-----GEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260
+L E L+ + +E+ GD +++ D ++ D + + +
Sbjct: 1853 HQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND----SWKERFLDVENELSRIR 1908
Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKE----ETEFLSIHSQMTNLED 1316
++ ++ L L+ L + QT+ + LE EN K E E + S+ L
Sbjct: 1909 SEKASIEHEALYLEADLEVV---QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRG 1965
Query: 1317 IDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVS 1376
+++ SK ++ D K++E+ QELES S ++ E + + LQ VS
Sbjct: 1966 -ELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS 2024
Query: 1377 ESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNI-VKLLEKQ 1435
E + + + E D+Q + C +N + E VKE ++ +L E
Sbjct: 2025 ELLKDKTHLQEKLQSLEKDSQ-ALSLTKCELENQIAQLNKEKELLVKESESLQARLSESD 2083
Query: 1436 YQEQLEEEVAKVIVSMSIAFA-----QQTELSRISGGKENTASSKQAHAVCQQEQHYFNE 1490
Y++ + + + FA Q E+ ++ G E +A +++ H +
Sbjct: 2084 YEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE--KKQLHIAEK 2141
Query: 1491 MKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE 1550
+K + E +K K E ++ E +E+++ D + + + T E
Sbjct: 2142 LKERER-------ENDSLKDKVENLERELQMSEENQELVI--LDAENSKAEVETLKTQIE 2192
Query: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE-EQLEDMRQELVRQYQEHQQATELLR 1609
EM K F E+ + ++ + ++ + + ++ + EL + + E
Sbjct: 2193 EMARSLKVF--------ELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 1610 QAHMRQMERQREDQEQLQEEIKRLNRQLA--------QRSSIDNENLVSERERVLLEELE 1661
QA ++ E + E LQ ++K LN +A +++ + + E E L +E
Sbjct: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304
Query: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNER 1721
L+ A +K C L+ + + +G VE +E E+ R +N+
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE-RELEIAR----------TNQE 2353
Query: 1722 YALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKS 1781
+A +A N ++ ET+ + G + +S + + RSE E
Sbjct: 2354 HAALEAENSKGEV------------ETLKAKIEG-MTQSLRGLELDVVTIRSEKE----- 2395
Query: 1782 CVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQ-RLVRSGFAGTEIDPENE 1840
N+ +++ +E +S+ ++ S F + E E
Sbjct: 2396 ---------------------------NLTNELQKEQERISELEIINSSFENILQEKEQE 2428
Query: 1841 ELMLNISS-----RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKC 1895
++ + S LQ +++L E ++ + E K ++Q + ++C
Sbjct: 2429 KVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA-----------KEQNLSSQVEC 2477
Query: 1896 QE-ELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLC 1954
E E + L A+ V S G+I D K +++++K + I RL+ ++
Sbjct: 2478 LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK----QKLEKKDEEISRLKNQI-- 2531
Query: 1955 ASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQ--QLLQETEKLMKEKLEVQCQA 2012
++L ++ Q++ E +L Q ++ +EQ Q+LQ +++ LEV +
Sbjct: 2532 --QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSS 2589
Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQ 2072
K ++ + K ++ E+V++ E E E+ ++ Q+ L+++L
Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEEL---------- 2639
Query: 2073 AIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132
E++ E+Q L +++K S+ Q +E+ + LK+ D + K
Sbjct: 2640 ----SGEKNRLAGELQLLLEEIK-------SSKDQLKELTLENSELKKSLD-----CMHK 2683
Query: 2133 EQLQRDIQERNEEIEKLEFRVRELE---QALLVSADTFQKVEDRKHFGAVEAKPELSLEV 2189
+Q++++ + R EEI + + R+ E E QALL+ + EV
Sbjct: 2684 DQVEKEGKVR-EEIAEYQLRLHEAEKKHQALLLDTNK-------------------QYEV 2723
Query: 2190 QLQAERDAIDRKEKEITNLE---EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2246
++Q R+ + KE+ +++ + + L+ +EEL N + Q+ +L+ K ++ + +
Sbjct: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQ 2783
Query: 2247 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI--IQEK-------EVEIDQL 2297
L++EN+ + M+ L + K+ + +++ +L + +Q+ QEK + ++D+L
Sbjct: 2784 LKKENERAQGKMKLLIKSCKQLE----EEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL 2839
Query: 2298 NEQVTKLQQQLKITTDNK-----------VIEEKNELIRD-LETQIECLMSDQ 2338
++ +L++ L+ T + EK E ++ LETQ+ L S Q
Sbjct: 2840 TTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQ 2892
Score = 192 bits (489), Expect = 4e-48
Identities = 530/2887 (18%), Positives = 1157/2887 (40%), Gaps = 458/2887 (15%)
Query: 972 EISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR--AENVQSCDTQVSSLLDGVVTMTSR 1029
+I L ++ LK+EK+Q + LE + + EN ++ T + ++ +
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE- 77
Query: 1030 GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089
S+ K + E ++ E +V+F+ + KQ + + L E R+ Q
Sbjct: 78 ----SLEKTKQKISHELQVK-ESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE-RSQQA 131
Query: 1090 SENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD-----KALC 1144
+++ + LN + Q + + Y ++ + +E K KAL
Sbjct: 132 AQSADVS--LNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189
Query: 1145 SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE--CSYF 1202
+ K Q HQ Q+ E P HL + + + SYF
Sbjct: 190 AKKASQTLPQATMNHRDIARHQASSSVFSWQQ---EKTPSHLSSNSQRTPIRRDFSASYF 246
Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPEL--------QDYRYEVQDFQE 1254
GE + + ++ + + + P L Q+ R ++ + +
Sbjct: 247 S-------GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299
Query: 1255 NMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMK-LEFGEENLPKEETEFLSIHSQMTN 1313
+ ++ + NK LQ +L K + + K L + L + ++ ++ T
Sbjct: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA 359
Query: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQ 1373
LE KL L + L Q Q ES SL+Q++KE E+ ++ E+ Q+ Q
Sbjct: 360 LEQ-------KLKKLTE----DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ 408
Query: 1374 AVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLE 1433
+ + + +T+ Q KN+ ++ + + T++ + LE
Sbjct: 409 TLDQECIQMKAR-----LTQELQQA---------KNMHNVLQAE----LDKLTSVKQQLE 450
Query: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG--KENTA----SSKQAHAVCQQEQHY 1487
+E ++++ + + + ++ EL R KEN S ++A VC E
Sbjct: 451 NNLEE-FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL 509
Query: 1488 FN-EMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSD--PHDIPESKDC 1544
N + L+Q Q + + + + + L +++ + + L D+ + +DC
Sbjct: 510 KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569
Query: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQA 1604
S+++ K + I + ++D++S + ++ L E ++++ + +E +
Sbjct: 570 ----SQDLLKKREHHI--EQLNDKLSKTEKESKALLSALE-----LKKKEYEELKEEKTL 618
Query: 1605 TELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALK 1664
+ + + + + ++E LQ +I L L + +E ERV E++
Sbjct: 619 FSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEY----NERVRTLEMD--- 671
Query: 1665 QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYAL 1724
RE L E+RN + + EVE Q EL +K E ++
Sbjct: 672 ------RENLSVEIRNLHNVLDSKSV---EVETQKLAYMELQQKAE-----------FSD 711
Query: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784
QK + + L+ + T VE+ H L +L + +E E+
Sbjct: 712 QKHQKEIENMCLKTSQLTGQVEDL--EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769
Query: 1785 EEHTRVTDESIPS--YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEID--PENE 1840
++ + VT+E + P + + + E+G+ S+R E D P+N
Sbjct: 770 KDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSER----SECRLEADQSPKNS 825
Query: 1841 ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELR 1900
++ N L+ ++E + S+ Q E + E+ E+ + ++ +S + R
Sbjct: 826 AILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEI-EENLMKAEQMHQSFVAETSQR 884
Query: 1901 -ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRL 1959
+L E++ A + + E A ++ E L +++ + I L++ + L
Sbjct: 885 ISKLQEDTSAHQNVVAETLSA---LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
Query: 1960 QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ---LLQETEKLMKEKLEVQCQAEKVR 2016
+EL+ + + E++ +S K E + Q+ L + L +EK+ + ++E
Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
Query: 2017 ---DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073
D+ +K + L +++ ++ +E DL Q+ +A +++ K+ L+E
Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
Query: 2074 I---DREHERDVFQQEIQKLEQQLKVVPRF-QPISEHQTREVEQLANHLK-EKTDKCSEL 2128
+R++E + ++ K Q+ F + +++ E+E + L+ E TD +
Sbjct: 1062 SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNS 1121
Query: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKH-FGAVEAKPELSL 2187
L+++I EE K++ V +L Q + KV KH +E++P +
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQ----ENEQLMKVMKTKHECQNLESEPIRNS 1177
Query: 2188 EVQLQAERDAIDRKEKEITNLEE-QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2246
+ ++ER+ + K + ++E L+ + +L +QLE + +LQE
Sbjct: 1178 VKERESERNQCNFKPQMDLEVKEISLDSYNAQL-----------VQLEAMLRNKELKLQE 1226
Query: 2247 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV-----EIDQLNEQV 2301
E+E + + +++ + ++ S+ Q Q + K +I E++ E+
Sbjct: 1227 SEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN 1286
Query: 2302 TKLQQQLKITTDNKVIE----------EKNELIRDL-ETQIECLMSDQECVKRNRE--EE 2348
LQ L+ TT NK+ E EK EL+ +L +++ EC+ + ++ + + E
Sbjct: 1287 AHLQCSLQ-TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNE 1345
Query: 2349 IEQLNEVIEKLQQELAN------IGQKTSMNAHSLS----EEADSLKH------QLDVVI 2392
++ LN+ L EL G++ + H +S +E++S +H ++ +
Sbjct: 1346 VKILNDDSGLLHGELVEDIPGGEFGEQPN-EQHPVSLAPLDESNSYEHLTLSDKEVQMHF 1404
Query: 2393 AEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER----ESVEKIQSIPE 2448
AE L+++ + E + + + + KM++L + SLK E ++ Q
Sbjct: 1405 AE---LQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLV 1461
Query: 2449 NSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF-EENGKGSIINLETRLLQLEST 2507
+ + ++ V +L SL + +++++ E+ G S+++ LE
Sbjct: 1462 KEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS------NLEGA 1515
Query: 2508 VSAKDLELTQCYKQIKDMQEQGQFETEMLQKK-IVNLQKIVE--EKVAAALVSQIQLEAV 2564
VSA + + + + + ET K + L+ + E + L +++ + +
Sbjct: 1516 VSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGI 1575
Query: 2565 QEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLIL 2624
+ + + Q +SSE + + L E+E +L S +EM + L
Sbjct: 1576 MKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ---------KLTSVTLEMESKLAA 1626
Query: 2625 EKEQVEIAEKNVLEKEKKLLELQKL---------------LEGNE------KKQREKEKK 2663
EK+Q E LE E L+LQ L ++G K+ + +
Sbjct: 1627 EKKQTEQLS---LELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTE 1683
Query: 2664 RSPQ-----------------DVEVLKTTTELFHSNEESG-------------------- 2686
R+P+ D+E + T + + E SG
Sbjct: 1684 RTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSS 1743
Query: 2687 -FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQ---------KDLSQV 2736
+EL + + + +E LQ L VKET+ +L+ + + +
Sbjct: 1744 ECISEL-SFSGPNALVPMDFLGNQEDIHNLQ--LRVKETSNENLRLLHVIEDRDRKVESL 1800
Query: 2737 RDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQ 2796
+ + E KL + E + T+++ AC I+L K + G LK +S+ + +
Sbjct: 1801 LNEMKELDSKLHLQEVQLMTKIE----AC------IELEKIV-----GELKKENSDLSEK 1845
Query: 2797 ILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR-----HISETE 2851
+ + C +E+ + + + +E + E+HA D SR ++++
Sbjct: 1846 LEYFS----------CDHQELLQRV-ETSEGLNSDLEMHA----DKSSREDIGDNVAKVN 1890
Query: 2852 TLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ 2911
+E ++ V+ + KA I E ++ A + QT ++C + +
Sbjct: 1891 DSWKERFLDVENELSRIRSEKASI------EHEALYLEADLEVVQTEKLCLEKDNENKQK 1944
Query: 2912 GIYLTHSQGFDIASEG---RGE-----ESESATDSFPKKIKGLLRAVHNEGMQVLSLTES 2963
I + + SE RGE + +A D +K+K + + + + L
Sbjct: 1945 VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECL----- 1999
Query: 2964 PYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWR 3023
H IQ V+E ++E+ + T+SS + K + + ++ + ++ S +
Sbjct: 2000 -------HCIQ-VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTK 2051
Query: 3024 GELLLALQQVFLEERSVLLAAFRTELTALGTTD--AVGLLNCLEQRIQEQGVEYQAAMEC 3081
EL + Q+ +E+ +L+ + L +D + + LE + E+G E+ +
Sbjct: 2052 CELENQIAQLN-KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKG-EFALRLSS 2109
Query: 3082 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141
Q+ E+ L + ++ ++ +++ + E L+ E + E
Sbjct: 2110 TQE--------EVHQLRRGIEKLRVRIEADEKKQLHIAEKLK-----------EREREND 2150
Query: 3142 SMKDRATELQE--QLSSEKMVVAELKSELAQTKLELETTLKAQHKHL-KELEAFRLEVKD 3198
S+KD+ L+ Q+S E + L +E ++ ++E TLK Q + + + L+ F L++
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVE---TLKTQIEEMARSLKVFELDLVT 2207
Query: 3199 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258
E L + +Q + EL L K+ L E+ + + E+ K ++E + + +
Sbjct: 2208 LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKE 2267
Query: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3318
LN + L Q+ +++ D + EE Q+ EK+R R D
Sbjct: 2268 LN----EAVAALCGDQEIMKATEQSLDPPIEEEH------QLRNSIEKLRAR---LEADE 2314
Query: 3319 ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY-KLDSLQTR 3377
+++L Q + + DLLK + LE R +E+ +++ L++ ++
Sbjct: 2315 KKQLCVLQQLKESEHHA-------DLLKGRVENLE----RELEIARTNQEHAALEAENSK 2363
Query: 3378 QQMEKDRQVHRKTLQTEQEANTEGQKKMH----ELQSKVEDLQRQLEEKRQQVYKLDLEG 3433
++E TL+ + E T+ + + ++S+ E+L +L+++++++ +L++
Sbjct: 2364 GEVE--------TLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIIN 2415
Query: 3434 QRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKES 3493
+ I+QE ++++++ +EK + + Q
Sbjct: 2416 SSFENILQEKEQEKVQMKEKSSTAMEMLQ------------------------------- 2444
Query: 3494 NYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQEN 3553
+L E+N +++ E + K Q ++S+++ L + ++ LQ ++I +Q +
Sbjct: 2445 --TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502
Query: 3554 IDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMV 3613
++ +I +++ + ++ +S + E+L+ + +++ G E+ +LRN+
Sbjct: 2503 VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLT 2562
Query: 3614 MKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEV 3673
++LE++I+ + A ++ + N+E +E E+ +K++ + + + A+
Sbjct: 2563 VELEQKIQVLQSKNASLQDTLEVLQSSYKNLE----NELELTKMDKMSFVEKVNKMTAKE 2618
Query: 3674 YKLKAEL 3680
+L+ E+
Sbjct: 2619 TELQREM 2625
Score = 188 bits (477), Expect = 1e-46
Identities = 587/3030 (19%), Positives = 1199/3030 (39%), Gaps = 452/3030 (14%)
Query: 668 DGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDL----QQSLVNSKSEEMTLQINE 723
+GL QKI+ ++ + D L ++ Q ++ L+ +Q + N K+E L+ E
Sbjct: 10 EGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK-RE 68
Query: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
Q+ +EI EK K + E+Q + + E Q+ + +++ +L+ S L+
Sbjct: 69 NQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERS 128
Query: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 843
++ + P + +++ S+ + EDLK++ N+E+
Sbjct: 129 QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSG----------SKYEDLKEK---YNKEV 175
Query: 844 EKQRNTFSFAEKNFEVNYQELQEEYA------CLLKVKDDLEDSKNKQELEYKSKLKALN 897
E++ K E + LQ + A + +D + ++ + +
Sbjct: 176 EER--------KRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSH 227
Query: 898 EELHLQRINPTTVKMKSSVF--DEDKTFVAETLEMGEVVEK----DTTELMEKLEVTKRE 951
+ QR P +S F +++ T TL++G+ D + L+ K +
Sbjct: 228 LSSNSQR-TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQ 286
Query: 952 KLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQS 1011
EL ++++L +L+ E+ + + L+ + E+ + E E ++N R E V++
Sbjct: 287 NQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRT 346
Query: 1012 ------CDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
T+ ++L + +T + S + N E ++ +E K+ + EE
Sbjct: 347 TAQYDQASTKYTALEQKLKKLTE---DLSCQRQN---AESARCSLEQKIKEKEKEFQEEL 400
Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDK-----LQKELNVLKSEQNDLRLQMEA--QRI 1118
++Q L + R TQ + K LQ EL+ L S + L +E Q++
Sbjct: 401 SRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL 460
Query: 1119 CLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETG 1178
C + Q + ENE +++ +K+E + ++ +++ LE + ++
Sbjct: 461 CRA----EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516
Query: 1179 DEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL--KCEVNAEDKENSGDYISE 1236
++ + + KA + L+ L + + K ++ D E D
Sbjct: 517 NQSQNF----AEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS-- 570
Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN 1296
QD + + E ++ L+K TE+ +K L+ L K E+ E
Sbjct: 571 ------QDLLKKREHHIEQLNDKLSK-TEKESKALLSALELKK----------KEY--EE 611
Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356
L +E+T F S+ KL + + EK L+ ++ LE+ + + QQ+K
Sbjct: 612 LKEEKTLFSCWKSE-----------NEKLLTQMESEKENLQSKINHLETCLKT--QQIKS 658
Query: 1357 TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEF 1416
E N + + +V + L SV E + Q+ Y + EF
Sbjct: 659 HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV---EVETQKLAY------MELQQKAEF 709
Query: 1417 SGEFGVKEETNIVKLLEKQYQEQLEEEVAKV-IVSMSIAFAQQT--ELSRISGGKENTAS 1473
S + KE N+ L Q Q+E+ K+ ++S I + +L +
Sbjct: 710 SDQKHQKEIENMC-LKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768
Query: 1474 SKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNS 1533
SK A V E H + + Q +F + +GE G S
Sbjct: 769 SKDASLVTN-EDHQRSLLAFDQQPAMHHSFANI--------------IGEQG-------S 806
Query: 1534 DPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE 1593
P E +C L E K + Q+ D + S +++ +Q+ L+ +E
Sbjct: 807 MPS---ERSECRL----EADQSPKNSAILQNRVDSLEFS-LESQKQM---NSDLQKQCEE 855
Query: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR-SSIDNE------ 1646
LV+ E ++ Q H + + +LQE+ +A+ S+++N+
Sbjct: 856 LVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQL 915
Query: 1647 -NLVSERERVLLEEL--------EALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEE 1697
N E E+ ++EL ++LK+L L E L E + S+ E+ +
Sbjct: 916 LNDKVETEQAEIQELKKSNHLLEDSLKELQLLS-ETLSLEKKEMSSIISLNKREIEELTQ 974
Query: 1698 QTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGIL 1757
+ KE++ L+ E+ L + + + E K+ + + + + L +L
Sbjct: 975 ENGTLKEINAS--------LNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 1758 DRSSKSQSSASLIWRSEAEASVKS----CVHEEHTRVTDESIPSYSGSDMPRNDINMWSK 1813
R ++ ++ + + A K+ C+ E T + + +N++ +
Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENR----------KNELEQLKE 1076
Query: 1814 VTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKV 1873
+ E + L + FA + N+ LML + + QA ++ + + + S+ K
Sbjct: 1077 AFAK--EHQEFLTKLAFA----EERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130
Query: 1874 TQTELMRESFRQKQEATESLKCQEEL----------------------RERLHEESRARE 1911
L E + ++E + L+ E+L +ER E ++
Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNF 1190
Query: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ----ELEAEQQ 1967
+ ++L E +D Y + E ++ K + E+E C + LQ +LE
Sbjct: 1191 KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNL 1250
Query: 1968 QIQEERELLSRQKEAMKAE----AGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQV 2023
Q + +E+ + + AE +GP E Q + +QC + + L +
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQN------DNAHLQCSLQTTMNKLNELE 1304
Query: 2024 KALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAI-DREHERDV 2082
K EI E+ EL ++ + R+ + + K L +++ D+ + E D+
Sbjct: 1305 KICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDI 1364
Query: 2083 FQQEI--QKLEQQ-LKVVPRFQPIS-EHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD 2138
E Q EQ + + P + S EH T +++ H E +K L + L
Sbjct: 1365 PGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQ 1424
Query: 2139 IQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAI 2198
+ + ++ +L+ V L+ LV + + + G + + +L LE L +
Sbjct: 1425 HCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQ-----GDLVKEMQLGLEEGLVPSLSSS 1479
Query: 2199 DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDM 2258
+ + +R LE + +++ + + + +++F +
Sbjct: 1480 CVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSV--------DEVFCSSL 1531
Query: 2259 EKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT--TDNKV 2316
++ L KE+ + A+ ++E E + + + KL+++++ NK
Sbjct: 1532 QEENLTRKETPSAP-----------AKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKE 1580
Query: 2317 IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2376
I+E +L+ +++CL ++ + N + + ++L V +++ +LA +K S
Sbjct: 1581 IQELEQLLSSERQELDCLR--KQYLSENEQWQ-QKLTSVTLEMESKLA--AEKKQTEQLS 1635
Query: 2377 LSEEADSLKHQ-LDVVIAEKLAL--EQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
L E L+ Q LD+ L + E ++ NE K ET + +
Sbjct: 1636 LELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD 1695
Query: 2434 KRERES----VEKI----------QSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLEN 2479
K ++ +EKI + E S + + +DK + + S N
Sbjct: 1696 KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPN 1755
Query: 2480 QTYFKSFEENGKGSIINLETRL-------LQLESTVSAKDLELTQCYKQIKDMQEQGQFE 2532
F N + I NL+ R+ L+L + +D ++ ++K++ + +
Sbjct: 1756 ALVPMDFLGNQE-DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQ 1814
Query: 2533 TEMLQKKI---VNLQKIVEE--KVAAALVSQIQLEAV--QEYAKFCQDNQTISSEPERTN 2585
L KI + L+KIV E K + L +++ + QE + + ++ ++S+ E
Sbjct: 1815 EVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLE--- 1871
Query: 2586 IQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2645
+ ++ +++G +++ + E V + + EK +E E LE + ++++
Sbjct: 1872 -MHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIE-HEALYLEADLEVVQ 1929
Query: 2646 LQKLL--EGNEKKQR--------------EKEKKRSPQDVEVLKTTTELFHSNEESGFFN 2689
+KL + NE KQ+ E+ + R D KTT S +
Sbjct: 1930 TEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQ 1989
Query: 2690 ELEALRAESV-ATKAELASYKEKAEKLQ------EELLVKETNMT----SLQKDLSQVRD 2738
ELE+ ++E + + A KEK E LQ ELL +T++ SL+KD +
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSL 2049
Query: 2739 HLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQIL 2798
E + +++ L KE E V+ES E L +LS+S K++ S L
Sbjct: 2050 TKCELENQIAQLNKEKELLVKES------ESLQARLSESDYE------KLNVSKALEAAL 2097
Query: 2799 VKNAGIQINLQSECSSEEVTEI---ISQFTEKIE--KMQELHAAEILDMESRHIS----E 2849
V+ + L S + EEV ++ I + +IE + ++LH AE L R +
Sbjct: 2098 VEKGEFALRLSS--TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155
Query: 2850 TETLKREHYVAVQ---LLKEECGTLKAVIQCLRSKEGSSIPELAHS-DAYQTREICSSDS 2905
E L+RE ++ + L+ + KA ++ L+++ I E+A S ++ +
Sbjct: 2156 VENLERELQMSEENQELVILDAENSKAEVETLKTQ----IEEMARSLKVFELDLVTLRSE 2211
Query: 2906 GSDWGQGIYLTHSQGFDI-----ASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSL 2960
+ + I Q ++ + + EE E A ++ K + + N Q+ L
Sbjct: 2212 KENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQN---QLKEL 2268
Query: 2961 TESPYSDGEDHSIQQVSE----PWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSH 3016
E+ + D I + +E P +EE N+I L+ +++ + ++ Q
Sbjct: 2269 NEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLR---ARLEADEKKQLCVLQQLK 2325
Query: 3017 ESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQE-----Q 3071
ES + +LL +V ER + +A E AL ++ G + L+ +I+ +
Sbjct: 2326 ES--EHHADLLKG--RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLR 2381
Query: 3072 GVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKI------TLKREQESEK--------P 3117
G+E ++++ +L +E+Q +++ +I + +E+E EK
Sbjct: 2382 GLELDVVTI---RSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSST 2438
Query: 3118 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET 3177
+ E+L+ +++ ++ + + + K + L Q+ ++ A+L L + K
Sbjct: 2439 AMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIV 2498
Query: 3178 TLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEER 3237
+ + ++E+E + +++ K +E+ L + + +++ +L + + +L + +
Sbjct: 2499 LQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV--EGEHQLWKEQNL 2556
Query: 3238 DKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQ-------RMLYDAQLSE 3290
EL +L LE + Q N L+ ++L S + +E++ +M + ++++
Sbjct: 2557 ---ELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
Query: 3291 EQGRNLELQVLLESEKVRIREMSSTLDRER-----ELHAQLQSSDGTGQSRPPLPSEDLL 3345
+ ELQ + + E+ L E+ EL L+ + L E+
Sbjct: 2614 MTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLEN-- 2671
Query: 3346 KELQKQLEEKHSRIVEL--------------LNETEK-YKLDSLQTRQQMEKDRQVHRKT 3390
EL+K L+ H VE L+E EK ++ L T +Q E + Q +R+
Sbjct: 2672 SELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREK 2731
Query: 3391 LQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQ--------------QVYKLDLEGQRL 3436
L +++E + + ++ L+S E+L L+ Q V +L E +R
Sbjct: 2732 LTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERA 2791
Query: 3437 QGIMQEFQKQELEREEKRESRRILYQNLNE 3466
QG M+ K + EE++E IL + L++
Sbjct: 2792 QGKMKLLIKSCKQLEEEKE---ILQKELSQ 2818
Score = 152 bits (384), Expect = 6e-36
Identities = 281/1418 (19%), Positives = 604/1418 (42%), Gaps = 165/1418 (11%)
Query: 73 VESTVIPESTIMRTLHSGEITSH--EQGFSVELESEI--STTADDCSSEVNGCSFVMRTG 128
+ S+ +P+S+ + +L EQ + L S + + +A+ CS + CS +
Sbjct: 1476 LSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEE- 1534
Query: 129 KPTNLLREEE-----FGVDD--SYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
NL R+E GV++ S E Q E MES+ K EI+EL + L
Sbjct: 1535 ---NLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSE 1591
Query: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
R Q L E E ++ + ++ + L +++ ++ E Q Q L +
Sbjct: 1592 RQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLS 1651
Query: 242 FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFL 301
+ L +T + + D+ + T + + + + + ++D + I +
Sbjct: 1652 SRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD--KDAQQDLNLDIEKI 1709
Query: 302 QEKIKV---------------YEMEQDKKVENS----------------------NKEEI 324
E V YE + K + S N+E+I
Sbjct: 1710 TETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDI 1769
Query: 325 QEKETIIEELNTK-------IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 377
+ ++E + + I + ++K L +++ D L + Q++ K + ++
Sbjct: 1770 HNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELE 1829
Query: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
+ K++ SE+++ +EL +R +D+ ++ ++ + A++
Sbjct: 1830 KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKV 1889
Query: 438 DEMYGQQIVQMKQEL--IRQHMAQMEEMKTRHKGEME-----------NALRSYSNITVN 484
++ + ++ + ++ EL IR A +E + ++E + I
Sbjct: 1890 NDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCL 1949
Query: 485 EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC-ALQRQLEDLVEELSFSREQ 543
E+++ ++ N+L +L DT S+K ++L ++EK L+ + + + + +
Sbjct: 1950 EEELSVVTSERNQLRGEL-DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAE 2008
Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
++ + + S ++E K + +++ + S++ + + E ++ + E+L
Sbjct: 2009 VKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELL 2068
Query: 604 EKEKNAVLDRMAES--QEAELERLRTQLLFSHEEELSKLKEDLEIEHRI--NIEKLKDNL 659
KE ++ R++ES ++ + + L E +L E H++ IEKL+ +
Sbjct: 2069 VKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRI 2128
Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTL 719
K+Q+ +++K++ + E D+L K L E+ ++ + Q LV +E
Sbjct: 2129 EADEKKQL-----HIAEKLKERERENDSLKDKVENLEREL-QMSEENQELVILDAENSKA 2182
Query: 720 QINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSI 779
++ L+ +IE + + K E ++ L+ + E L KQ++EK+ L E L + S+
Sbjct: 2183 EVETLKTQIEEMARSLK---VFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSL 2239
Query: 780 LKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK-QQCIQ 838
L +EK+ E +K + + E L + ++EI E++ D ++ Q
Sbjct: 2240 L-EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQ 2298
Query: 839 LNEEIEKQRNTFSFAEKNFEVNYQELQ--EEYACLLKVKDD-----------------LE 879
L IEK R EK Q+L+ E +A LLK + + LE
Sbjct: 2299 LRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALE 2358
Query: 880 DSKNKQELE-YKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 938
+K E+E K+K++ + + L ++ T++ + + E + E++
Sbjct: 2359 AENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSF 2418
Query: 939 TELMEKLEVTKREKLELSQRLSD----LSEQLKQKHGEISFLNEEVKSLKQEKEQVS--L 992
++++ E +EK+++ ++ S L QLK+ + ++ L+ + ++ K +++ +S +
Sbjct: 2419 ENILQEKE---QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQV 2475
Query: 993 RCRELEIIINHNRAENVQSCDTQVSS--LLDGVVTMTSRGAEGSVSKVNKSFGEESKI-- 1048
C ELE +A+ +Q D ++ +L V + E K+ K E S++
Sbjct: 2476 ECLELE------KAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKN 2529
Query: 1049 MVEDK---VSFENMTVGEES--KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLK 1103
++D+ VS + GE K++ L L +L +V E ++ Q S+N LQ L VL+
Sbjct: 2530 QIQDQEQLVSKLSQVEGEHQLWKEQNLELRNL-TVELEQKIQVLQ-SKNASLQDTLEVLQ 2587
Query: 1104 SEQNDLRLQMEAQRICLSLVYSTHVDQVREY--MENEKDKALCSLKEELIFAQEEKIKEL 1161
S +L ++E + + + V++V + E E + + + ++ QEE E
Sbjct: 2588 SSYKNLENELELTK----MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643
Query: 1162 QKI-HQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKC 1220
++ +L+L + + + D+ K L L +L+K++ +C + Q +
Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL--DCMHKDQVEKEGKVREEIAEYQL 2701
Query: 1221 EVNAEDKENSGDYISENE--DPELQDYRYEVQDFQENMHT------LLNKVTEEYNKLLV 1272
++ +K++ + N+ + E+Q YR ++ +E + + LL EE N L
Sbjct: 2702 RLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLK 2761
Query: 1273 LQTR-LSKIWGQQTDGMKL--EFGEENLPKEETEFLSIHS--QMTNLEDIDVNHKSKLSS 1327
T+ L ++ + D +K + +EN + L I S Q+ ++I S+L +
Sbjct: 2762 ATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQA 2821
Query: 1328 LQDLEK------TKLEEQVQELESLISSLQQQLKETEQ 1359
Q+ +K TK++E E++ L +L+++ KE ++
Sbjct: 2822 AQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADE 2859
Score = 145 bits (365), Expect = 1e-33
Identities = 218/1095 (19%), Positives = 473/1095 (43%), Gaps = 170/1095 (15%)
Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
E+ + +KLE + QR S+G + + D S+ D+ + ++
Sbjct: 1838 ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA---------DKSSREDIGDNVAK 1888
Query: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
N+ + VE+ + + S + + + +E + E+ T C + N
Sbjct: 1889 VNDSWKERFLDVENE-------LSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN-- 1939
Query: 122 SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
+ + EEE V S Q + T + + L +++E +ELE
Sbjct: 1940 ----ENKQKVIVCLEEELSVVTSERNQLRGELDT-MSKKTTALDQLSEKMKEKTQELE-- 1992
Query: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
++ +E L +Q EA +K++ ++ L++++ + ++K + L + SQ L +
Sbjct: 1993 --SHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050
Query: 242 FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE-DYQKKKEDFTMQISF 300
+L+ + A L + K+ ++ + L Q L E DY+K ++ +
Sbjct: 2051 KCELE-----------NQIAQLNKEKELLVKESESL--QARLSESDYEKLNVSKALEAAL 2097
Query: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
+++ + +S +EE+ + IE+L +I +EKK L + +KL ++
Sbjct: 2098 VEKGEFALRL-------SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
Query: 361 ELQEQIVQKNQEI----KNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
L++++ +E+ +N +L + +++ S E++ L +EE+ + FE
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAE----NSKAEVETLKTQIEEMAR---SLKVFEL 2203
Query: 417 DIV------QRMEQETQRKLEQLRAELDEMYG----------QQIVQMKQ------ELIR 454
D+V + + ++ Q K QL +ELD++ Q +Q+K+ E+++
Sbjct: 2204 DLVTLRSEKENLTKQIQEKQGQL-SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQ 2262
Query: 455 QHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKE 514
+ ++ E G+ E + ++ ++ + +I +L +L+ ++ + +
Sbjct: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322
Query: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
+L L+ ++E+L EL +R QE EA S VE LKA+
Sbjct: 2323 QLKESEHHADLLKGRVENLERELEIAR----------TNQEHAALEAENSKGEVETLKAK 2372
Query: 575 IVSASESRKELELK----------------------HEAEVTNYKIKLEMLEKEKNAVLD 612
I ++S + LEL E E+ N + + EKE+ V
Sbjct: 2373 IEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKV-- 2430
Query: 613 RMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQN 672
+M E +E L+TQL E ++ L D E + + NL Q++ L+
Sbjct: 2431 QMKEKSSTAMEMLQTQLK-ELNERVAALHNDQEA-----CKAKEQNL----SSQVECLEL 2480
Query: 673 EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR 732
E +Q ++ + K+N I Q+ + I +++D +Q L K EE++ N++Q + +++
Sbjct: 2481 EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL-EKKDEEISRLKNQIQDQEQLVS 2539
Query: 733 QEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK 792
+ + +G Q +E L+ L ++++K LQ K A L+ +L+ K LE+ L+
Sbjct: 2540 KLSQVEGE-HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
Query: 793 IHTPVSQEERLIFLDSI-KSKSKDSVWEKEIEILIEENEDLKQQCI-----------QLN 840
+ ++ +++ F++ + K +K++ ++E+ + ++ +L+++ L
Sbjct: 2599 L----TKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLL 2654
Query: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
EEI+ ++ K + EL++ C+ K + + E ++ EY+ +L E+
Sbjct: 2655 EEIKSSKDQL----KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEA-EKK 2709
Query: 901 HLQRINPTTVK-------MKSSVFDEDKTFVAETLEMGEVVE---------KDTTELMEK 944
H + T + + + +++ ++ LE+ + K TT+++E+
Sbjct: 2710 HQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEE 2769
Query: 945 LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004
L+ TK + L+ ++ L ++ ++ G++ L + K L++EKE + +L+
Sbjct: 2770 LKKTKMDNLKY---VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
Query: 1005 RAENVQSCDTQVSSL 1019
+ V DT+V L
Sbjct: 2827 KTGTVM--DTKVDEL 2839
Score = 132 bits (333), Expect = 5e-30
Identities = 334/1714 (19%), Positives = 693/1714 (40%), Gaps = 289/1714 (16%)
Query: 2025 ALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA----------- 2073
ALE E +R ++ QE +L L+++ Q + QL+ + L +Q
Sbjct: 4 ALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT 63
Query: 2074 -IDREHER-----DVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC-S 2126
+ RE++R + ++ QK+ +L+V E Q ++ L+++ +C S
Sbjct: 64 NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
Query: 2127 ELLLSKEQLQ-------------------------------RDIQER-NEEIE---KLEF 2151
EL S++ Q D++E+ N+E+E +LE
Sbjct: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
Query: 2152 RVRELE---------QALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK- 2201
V+ L+ QA + D + F + K L ++R I R
Sbjct: 184 EVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHL--SSNSQRTPIRRDF 241
Query: 2202 -------EKEITNLEEQLEQFREELENK---NEEVQQLHMQLEIQKKESTTRLQEL---- 2247
E+E+T L+ + + + N L QL+ Q +E ++ EL
Sbjct: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRL 301
Query: 2248 ---EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2304
E+E K + ++L L ++++ + + VL K + + DQ + + T L
Sbjct: 302 QGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL-NKCRDELVRTTAQYDQASTKYTAL 360
Query: 2305 QQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELA 2364
+Q+LK T++ + +N +E + ++E + +EE+ + + L QE
Sbjct: 361 EQKLKKLTEDLSCQRQN--AESARCSLEQKIKEKE---KEFQEELSRQQRSFQTLDQECI 415
Query: 2365 NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424
+ + + + L+ +LD + + K LE +E +++ + + + K N
Sbjct: 416 QMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKEN 475
Query: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484
+L + + +K+E N + + +++ LE L +K NQ+ +
Sbjct: 476 ELRRSMEEMKKE-----------NNLLKSHSEQKAREVCHLEAELKN--IKQCLNQS--Q 520
Query: 2485 SFEENGKGSIINLETRLLQLESTVSAKD--LELTQCYKQIKDMQEQGQFETEMLQKKIVN 2542
+F E K + ET L L+ ++ ++ L L + + D+++Q ++L+K+ +
Sbjct: 521 NFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHH 580
Query: 2543 LQKIVE-----EKVAAALVSQIQLEAVQEYAKFCQDNQTIS------------SEPERTN 2585
++++ + EK + AL+S ++L+ +EY + ++ S E E+ N
Sbjct: 581 IEQLNDKLSKTEKESKALLSALELKK-KEYEELKEEKTLFSCWKSENEKLLTQMESEKEN 639
Query: 2586 IQN----------LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKN 2635
+Q+ Q++ E + L + L ++ +H +L+ + VE+ +
Sbjct: 640 LQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN--VLDSKSVEVETQK 697
Query: 2636 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFH-----SNE------- 2683
+ +ELQ+ E +++K +++ + + ++ +L H SNE
Sbjct: 698 L-----AYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC 752
Query: 2684 ESGFFNELEALRAESVATKAELASYKEKAEKL-----QEELLVKETNMT----SLQKDLS 2734
E E+LR + A L + ++ L Q + N+ S+ + S
Sbjct: 753 YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERS 812
Query: 2735 QVRDHLAEAKEKLSILE-KEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
+ R ++ + +IL+ + D E + M L + + + + + + + Q
Sbjct: 813 ECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQ 872
Query: 2794 TPQILVKNAGIQIN-LQSECSSEE--VTEIISQFTEKIEKMQ------ELHAAEILDM-E 2843
Q V +I+ LQ + S+ + V E +S K +++Q E AEI ++ +
Sbjct: 873 MHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKK 932
Query: 2844 SRH-----------ISETETLKREHYVA--------VQLLKEECGTLKAVIQCLRSKEGS 2884
S H +SET +L+++ + ++ L +E GTLK + L ++ +
Sbjct: 933 SNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMN 992
Query: 2885 SIPEL-AHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKI 2943
I + + ++ RE S+ + Q + R EE+ +A + +K
Sbjct: 993 LIQKSESFANYIDEREKSISELSDQYKQEKLILLQ---------RCEETGNAYEDLSQKY 1043
Query: 2944 KGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQL 3003
K N ++ L + + + ++Q+ E + +E + ++ ++ ++ + L
Sbjct: 1044 KAAQE--KNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLML 1101
Query: 3004 QRE-------AEVYDSSQSHESFSDWRGELLLALQQV----------FLEERSVLLAAFR 3046
+ E +E+ D+ + +S + + ++ L++ L+E L+ +
Sbjct: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMK 1161
Query: 3047 TELTALGTTDAVGLLNCLEQRIQEQG-VEYQAAMEC-LQKADRRSLLSEIQALHAQMNGR 3104
T+ ++ + N +++R E+ ++ M+ +++ S +++ L A + +
Sbjct: 1162 TK-HECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK 1220
Query: 3105 KITLKREQESEKPSQELLEYNIQQ-----KQSQMLEMQ-VELSSMKDRATELQEQLSSEK 3158
++ L QESEK +E L++ +Q + S + +MQ E+S +KD + +E+ S
Sbjct: 1221 ELKL---QESEK-EKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGP 1276
Query: 3159 MVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDT----LASEQ 3214
++ +++ A + L+TT+ ++ K E + E K + V LND+ + + +
Sbjct: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAE---KYELVTELNDSRSECITATR 1333
Query: 3215 KKSRELQWALEKEKAKLGRSEERDKEELEDL---KFSLESQKQRNLQLN----------- 3260
K + E+ L + K S E +ED+ +F + +Q + L
Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHL 1393
Query: 3261 LLLEQQKQL----LNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
L +++ Q+ L E ++S+ + Q + + ELQ ++S K +S+ L
Sbjct: 1394 TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNL 1453
Query: 3317 -----DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3371
D +E+ L+ S +P L L S LL +T L
Sbjct: 1454 RNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDS-----SFYRALLEQTGDMSL 1508
Query: 3372 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431
S V + QE N ++ VE+L+ E RQ + KL+
Sbjct: 1509 LSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLE- 1567
Query: 3432 EGQRLQGIMQEFQKQELER---EEKRESRRILYQNLNEPTTW--SLTSDRTRNWVLQQKI 3486
E QGIM+ + QELE+ E++E + Q L+E W LTS ++ K+
Sbjct: 1568 EKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLE---MESKL 1624
Query: 3487 EGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ 3520
E K++ L ELE+ R +LQ
Sbjct: 1625 AAEKKQTEQLSL------------ELEVARLQLQ 1646
Score = 91.3 bits (225), Expect = 2e-17
Identities = 130/584 (22%), Positives = 263/584 (45%), Gaps = 71/584 (12%)
Query: 128 GKPTNLLREEEFG-VDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYG 186
G+ NL RE E + ++ A++S +E +++++ G + L EL+ + +
Sbjct: 2336 GRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGL--ELDVVTIRSE 2393
Query: 187 TEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQL 245
E L +LQ+ + I + + II N+ Q + ++ M+E + + + LQ Q ++L
Sbjct: 2394 KENLTNELQKEQERISELE-IINSSFENILQEKEQEKVQMKE--KSSTAMEMLQTQLKEL 2450
Query: 246 QASETLRNSTHSSTAADLLQAKQQILTHQQQ-LE-EQDHLLEDYQKKKEDFTM---QISF 300
+ H+ A +AK+Q L+ Q + LE E+ LL+ + K ++ + ++
Sbjct: 2451 NERVA---ALHNDQEA--CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNG 2505
Query: 301 LQEKIKVYEMEQDKKVENSN--KEEIQEKETIIEELNT----------KIIEEEKKTLEL 348
L ++++ + + +KK E + K +IQ++E ++ +L+ + +E T+EL
Sbjct: 2506 LIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVEL 2565
Query: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 408
+ K+ LQ+ + KN++ EL +K + E++ ++ ELQ+
Sbjct: 2566 EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM 2625
Query: 409 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 468
H+ +Q ++ + + E R +L+ L+E+ + +EL ++ + + HK
Sbjct: 2626 HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK--DQLKELTLENSELKKSLDCMHK 2683
Query: 469 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE----KLKEELGLILEEKC 524
++E + I E Q++L + A + L DTN Q E +E+ L +E+C
Sbjct: 2684 DQVEKEGKVREEIA--EYQLRL-HEAEKKHQALLLDTNKQYEVEIQTYREK--LTSKEEC 2738
Query: 525 ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH-KSLSTVEDLKAEIVSASESRK 583
++LE ++ L S+E++ + + + +L + +L V LK E A K
Sbjct: 2739 LSSQKLE--IDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2796
Query: 584 EL-----ELKHEAEVTNYKIKLEMLEKEK---NAVLDRMAESQEAELERLR--------- 626
L +L+ E E+ ++ +EK V+D + E++ L+
Sbjct: 2797 LLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKE 2856
Query: 627 --------TQLLFSHEEELSKLKEDLE--IEHRINIEKLKDNLG 660
LL SH E+L K KE LE + H + + +D+ G
Sbjct: 2857 ADEYLDKYCSLLISH-EKLEKAKEMLETQVAHLCSQQSKQDSRG 2899
Score = 48.9 bits (115), Expect = 1e-04
Identities = 101/531 (19%), Positives = 208/531 (39%), Gaps = 88/531 (16%)
Query: 3220 LQWALEKEKA------------------KLGRSEERDKEELEDLKFSLESQKQ-----RN 3256
+ WALE+ K KL + +++ + +L+ L+ +L+ QKQ +
Sbjct: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60
Query: 3257 LQLNLLLEQQK-----QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3311
NL E Q+ + L +++QKI + + ++Q++ ++G+ + +E + ++
Sbjct: 61 EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120
Query: 3312 MSSTLDRERELHAQLQSSD------GTGQ---SRPPLPSEDLLKELQKQLEEKHSRIVEL 3362
S L+R ++ QS+D T Q + P PS+ + L+EK+++ VE
Sbjct: 121 CKSELERSQQ---AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE- 176
Query: 3363 LNETEKYKLDS-LQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEE 3421
E+ +L++ ++ Q + + + + T+ A + + Q +
Sbjct: 177 ----ERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS 232
Query: 3422 KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP---TTWSLTSDRTR 3478
+R + + D G + + + KR++ + N + P + R
Sbjct: 233 QRTPI-RRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291
Query: 3479 NWV--LQQKIEGETKESN----------------YAKLIEMNGGGTGCNHELEMIRQKLQ 3520
N + L+ +++G KE +LIE C EL +
Sbjct: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
Query: 3521 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL-QKLTGQQGE-EPSLVSPS 3578
++K L QK + ED ++N + L QK+ ++ E + L
Sbjct: 352 QASTKYTALEQKLKKL-------TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404
Query: 3579 TSCGSLTERLLRQNAELTGHISQ-------LTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3631
S +L + ++ A LT + Q L E + L ++ +LE + ++Q +
Sbjct: 405 RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAE 464
Query: 3632 NSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
+ + S E + E +E L+ ++ EV L+AEL+N
Sbjct: 465 QAFQAS----QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKN 511
Score = 48.9 bits (115), Expect = 1e-04
Identities = 124/624 (19%), Positives = 262/624 (41%), Gaps = 88/624 (14%)
Query: 3135 EMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL----- 3189
E++ +L +K + Q QL S + + + K ++ K E T LK +++ L E+
Sbjct: 22 ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE-GTNLKRENQRLMEICESLE 80
Query: 3190 ---EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK 3246
+ E++ K +V+ L S +K+ +L+ L++ K++L RS++ + D+
Sbjct: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ--AAQSADVS 138
Query: 3247 FSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEK 3306
+ + Q+ L Q S K E + Y+ ++ E + E++ L+++K
Sbjct: 139 LNPCNTPQKIFTTPLTPSQY-----YSGSKYEDLKEKYNKEVEERKRLEAEVKA-LQAKK 192
Query: 3307 VRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNET 3366
+T++ Q SS + Q +EK + ++
Sbjct: 193 ASQTLPQATMNHRDIARHQASSSVFSWQ------------------QEKTPSHLSSNSQR 234
Query: 3367 EKYKLDSLQTRQQMEKDRQVHRKTLQT-EQEANT---EGQKKMHELQSKVEDLQRQLEEK 3422
+ D + E++ R TLQ +++AN+ + H L + L+ Q +E
Sbjct: 235 TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL----DQLKAQNQEL 290
Query: 3423 RQQVYKLDLEGQ----RLQGIMQEFQKQELEREEKR----ESRRILYQNLNE--PTTWSL 3472
R ++ +L+L Q ++G + +FQ+ +L+ E+ + E ++L + +E TT
Sbjct: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350
Query: 3473 TSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHEL-----------EMIRQKLQC 3521
T+ L+QK++ T++ + + N C+ E E+ RQ+
Sbjct: 351 DQASTKYTALEQKLKKLTEDLSCQR---QNAESARCSLEQKIKEKEKEFQEELSRQQRSF 407
Query: 3522 VASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSC 3581
+ + KA + + A + + +Q +D++ Q+L E + +
Sbjct: 408 QTLDQECIQMKARLTQELQQAKNMHNV-LQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466
Query: 3582 GSLTERLLRQNAELTGHISQLTEEKNDLRN-------MVMKLEEQIRWYRQTGAGRDNSS 3634
++ +++N EL + ++ +E N L++ V LE +++ +Q N +
Sbjct: 467 FQASQ--IKEN-ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
Query: 3635 RFSLNGGANIEAIIASEKEVWNREK--LTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPD 3692
+ E ++ +E N+++ LTL+K LK A A++ K + Q L
Sbjct: 524 EEMKAKNTSQETMLRDLQEKINQQENSLTLEK-LKLAVADLEKQR------DCSQDLLKK 576
Query: 3693 SEHVTLKRIYGKYLRAESFRKALI 3716
EH ++++ K + E KAL+
Sbjct: 577 REH-HIEQLNDKLSKTEKESKALL 599
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 241 bits (614), Expect = 1e-62
Identities = 508/2542 (19%), Positives = 1040/2542 (40%), Gaps = 456/2542 (17%)
Query: 128 GKPTNLLREEEFGVDDSYSEQGAQ--DSPTHLEM---MESELAGKQHEIEELNREL--EE 180
G+ T LR E ++ ++ + D LE + +LA + E E N +L E
Sbjct: 107 GRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRREN 166
Query: 181 MRVTYGTEGL--------QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELT 232
R+ E L +Q+ + + R G + + L + E + + E LT
Sbjct: 167 KRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLT 226
Query: 233 EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE 292
E ++K+++Q Q+++ + L S + + + HQ D++++ +K+ +
Sbjct: 227 EANEKIEVQNQEMR--KNLEESVQEMEKMTDEYNRMKAIVHQT-----DNVIDQLKKEND 279
Query: 293 DFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKL 352
+ +Q+ L + +K + E+D + + +++E + I+ + +IIE ++ L++KL
Sbjct: 280 HYQLQVQELTDLLKS-KNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKL 338
Query: 353 TTA----DKL-LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEE---- 403
A DK + LQ+ I +++ +IK + ++ ++ +++ I+ L ++
Sbjct: 339 KNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGA 398
Query: 404 --LQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQME 461
L ++ H Q DI++ +E +R E A+ E K + + + + +++
Sbjct: 399 STLSQQTHMKIQSTLDILKEKTKEAERTAELAEADARE---------KDKELVEALKRLK 449
Query: 462 EMKTRHKGEMENALRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELG 517
+ ++ G +E+A+ N I + + +I+++ IN+L +K+ D + E L+E +G
Sbjct: 450 DYESGVYG-LEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVG 508
Query: 518 L----------ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST 567
L K Q+Q + L E ++ R + ++ ++ + S
Sbjct: 509 LEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSA 568
Query: 568 VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRT 627
L E ++ +E+ + + E ++ +K + KN L R +E +LER RT
Sbjct: 569 TSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRT 628
Query: 628 QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDN 687
++ + +L +L E+ +Q++ E+ Q I+ MQ + D
Sbjct: 629 -VIAKFQNKLKELVEE--------------------NKQLEEGMKEILQAIKEMQKDPD- 666
Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSE-------EMTLQINELQKEIEILRQE----EK 736
K + L I L+ L ++ + +E + Q+++L E LRQE K
Sbjct: 667 --VKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRK 724
Query: 737 EKGTLEQEVQELQLKTELLEKQ---MKEKEN--------DLQEKFA-------------- 771
E Q++ + LK + LEK+ +++ E DL + A
Sbjct: 725 EAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYL 784
Query: 772 -----QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI 826
+LE + LK+ + +LED + + ++ L++ + + K W+ E + +
Sbjct: 785 IHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKE---TWKTESKTIK 841
Query: 827 EENEDLKQQCIQLNEEIEKQRNTFSFAEKN-----------------FEVNYQELQEEYA 869
EE L+ Q Q ++++ N + + + +VN + L +Y
Sbjct: 842 EEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYT 901
Query: 870 CLLKVKDDLEDSKNKQELEYKSKLKALNEELH-LQRINPTTVKMKSSVFDEDKTFVAETL 928
L++++ L KQ+ E S + E++ LQR F E F L
Sbjct: 902 TLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQR------------FKEMAIFKIAAL 949
Query: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ---LKQKHGEISFLNEEVKSLKQ 985
+ +VV+ + + +LE+ ++ EL+ + D+ ++ L Q+ + L E SLK+
Sbjct: 950 Q--KVVDNSVS--LSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKE 1005
Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
+ E ++ +ELEI + ++ Q + L G E S+ K KS
Sbjct: 1006 QVESIN---KELEI--TKEKLHTIEQAWEQETKL----------GNESSMDKAKKSITNS 1050
Query: 1046 SKIMVEDKVSFENMT-VGEESKQE--QLILDHLPSVTKESSLR----ATQPSENDK---- 1094
+ + K++ M + E + E Q + +HL + K+ R T+ +E K
Sbjct: 1051 DIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD 1110
Query: 1095 -------LQKEL--------------NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVRE 1133
L+ EL +L+ E+N++ L++E ++ + ++
Sbjct: 1111 AQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILN 1170
Query: 1134 YMENEKDKALCSLKEELIF--AQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKL 1191
+ +DK + SL+ +L+ AQ ++ + K+HQ + ++ T +GKL
Sbjct: 1171 AQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA---------LGKL 1221
Query: 1192 QKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQD 1251
+ S+ LQ + E Y L+ E ++KE + Y + R +Q
Sbjct: 1222 ESITSK-----LQKM-----EAYN--LRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQS 1269
Query: 1252 FQENMHTLLNKVTEE-YNKLLV-LQTRLSKIWGQQTDGMKLEFGEENLPKE-ETEFLSIH 1308
+ L +E ++K ++ LQ KI + + + EN E E + +
Sbjct: 1270 LRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLE 1329
Query: 1309 SQMTNLEDID-----VNHKSKLSSLQDLEKTKLEEQ--------------VQELESLISS 1349
++ L+D +N K+ L+ L++ KL + + E E ISS
Sbjct: 1330 ELISTLKDTKGAQKVINWHMKIEELR-LQELKLNRELVKDKEEIKYLNNIISEYERTISS 1388
Query: 1350 LQQQLKETEQNYEA------------------------EIHCLQKRLQAVSESTVPPSLP 1385
L++++ + + +E EI ++ + + S PSLP
Sbjct: 1389 LEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLP 1448
Query: 1386 VDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVA 1445
+ + + A R +K+NI +E EE KL EK+ +L E+
Sbjct: 1449 LPNQL---EIALRK------IKENIRIILETRATCKSLEE----KLKEKESALRLAEQNI 1495
Query: 1446 ----KVIVSMSI---AFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFN-EMKLSQDQ 1497
KVI + + A A++ +L G KE K H + Q N + +L+Q +
Sbjct: 1496 LSRDKVINELRLRLPATAEREKLIAELGRKE--MEPKSHHTLKIAHQTIANMQARLNQKE 1553
Query: 1498 IGFQTFETVDVKFKEEFKPLSKELGE-----HGKEILLSNSDPHDIPESKDCVLTISEEM 1552
+ ++ + K +EE + + K+ E H + L ++S + ++ ++ S
Sbjct: 1554 EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTP 1613
Query: 1553 FSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAH 1612
+K FI + E +V+ D S +L +L+ + Q+L RQ + + +
Sbjct: 1614 VPTNKHFIRLAEM--EQTVAEQDDSLSSLL--VKLKKVSQDLERQREITELKVKEFENIK 1669
Query: 1613 MRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE--------------RVLLE 1658
++ E ++ ++++ E++ L + L +S +++ L SE + R L+E
Sbjct: 1670 LQLQENHEDEVKKVKAEVEDL-KYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVE 1728
Query: 1659 ELE---ALKQLSLAGREKLCCELRNSSTQTQNGN--ENQGEVEEQTFKEKELDRKPEDVP 1713
L+ ALK+ + ELR T + E ++ +DR ++
Sbjct: 1729 RLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELK 1788
Query: 1714 PEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRS 1773
++ + N LLK L E +KT+ E ++ ++ + + K Q + + I R
Sbjct: 1789 TQV--------EDLNENLLK-LKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILRE 1839
Query: 1774 EAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGT 1833
+ E ++ +E R G + N ++ ++ + +L +L
Sbjct: 1840 KEEIDQEN---DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQL-EGKVEEV 1895
Query: 1834 EIDPENEE------LMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ 1887
++ P E+ + + QA +E + + E ++ Q +++ F +
Sbjct: 1896 DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEV-FTLTKQLNTLKDLFAKAD 1954
Query: 1888 EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
+ E L Q +L+ + A+E K + + L +R + + DI+
Sbjct: 1955 K--EKLTLQRKLKTTGMTVDQVLGIRALESEK---------ELEELKKRNLDLENDILYM 2003
Query: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV-----------EQQLLQ 1996
+ L + +++L + + +QE+ L +Q + EQ+L +
Sbjct: 2004 RAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQK 2063
Query: 1997 ETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQ 2056
E KL E +E++ Q E+ DL + +K D++E + + E +L +R +
Sbjct: 2064 ENLKLSSENIELKFQLEQANKDLPR-LKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGR 2122
Query: 2057 A------LEKQLEKMRKFLDEQAIDREHER------DVFQQEIQKLEQQL-KVVPRFQPI 2103
+ LEK + M+K +++ + RE+E+ + +++ +EQ+ K+ + +
Sbjct: 2123 SGKTIPELEKTIGLMKKVVEK--VQRENEQLKKASGILTSEKMANIEQENEKLKAELEKL 2180
Query: 2104 SEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVS 2163
H QL+ H + KT +++ E+L++++++ + EKL LE +L
Sbjct: 2181 KAHLGH---QLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE--ILNE 2235
Query: 2164 ADTFQKVEDRKHFGAVEAK-PELS---------------LEVQLQAERDAIDRKEKEITN 2207
T Q E K E++ P+L E +L+ I +K + IT+
Sbjct: 2236 KMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITD 2295
Query: 2208 LEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE 2267
L++ +++ E + N+ + L Q++I K + E + + K +++ L LA
Sbjct: 2296 LKQLVKEATEREQKVNKYNEDLEQQIKILK-----HVPEGAETEQGLKRELQVLRLA--- 2347
Query: 2268 SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL 2327
H L + A++I + E DQ + T D ++EK I+DL
Sbjct: 2348 --------NHQLDKEKAELIHQIEANKDQSGAEST--------IPDADQLKEK---IKDL 2388
Query: 2328 ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQ 2387
ETQ++ MSD E + L E I+KL++EL N S EE + LK+
Sbjct: 2389 ETQLK--MSDLEK---------QHLKEEIKKLKKELENFDP-------SFFEEIEDLKYN 2430
Query: 2388 LDVVIAEKLALEQQVETANEEM 2409
+ + + LE++V+ +E++
Sbjct: 2431 YKEEVKKNILLEEKVKKLSEQL 2452
Score = 221 bits (562), Expect = 1e-56
Identities = 496/2623 (18%), Positives = 1110/2623 (42%), Gaps = 357/2623 (13%)
Query: 290 KKEDFTMQISFLQEKIKVYEMEQDKK---------VENSNKEEIQEKETIIEELNTKIIE 340
++E+ + K++V E++ +K+ ++ K + QE E +EE+ E
Sbjct: 20 RQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEE 79
Query: 341 EEK-------KTLELKDKLTTADKLLG------------ELQEQIVQKNQEIKNMKLELT 381
+ K K ++L+++L A + G +L++Q+ QK++E+++M+ EL
Sbjct: 80 QAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKEL- 138
Query: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
+KE++ +E QL EE + N K ++R + ++K EQL ++ + Y
Sbjct: 139 ---EKEKKVNE---QLALRNEEAENENSK--------LRRENKRLKKKNEQLCQDIID-Y 183
Query: 442 GQQIVQMKQELI--RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499
+QI K+ L+ R + ++ E+ L +T ++I++ N E+
Sbjct: 184 QKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQN---QEMR 240
Query: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559
L+++ + EK+ +E + A+ Q ++++++L + Q Q + + N
Sbjct: 241 KNLEESVQEMEKMTDEYNRMK----AIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN 296
Query: 560 EAHKSLSTVEDLKAE---IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616
E + + K E ++ +S+ + +E + K+K L+ +K+ V+
Sbjct: 297 EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQG 356
Query: 617 SQEAELE-RLRTQLLFSHEEELSK---LKEDL--EIEHRINIEKLKDNLGIHYKQQIDGL 670
QE + + ++ T+ + + +E+ K + EDL E++ L + + +D L
Sbjct: 357 IQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDIL 416
Query: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
+ + + T + + + K +L+ + +LKD + + E+ ++I + +I+I
Sbjct: 417 KEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGL--EDAVVEIKNCKNQIKI 474
Query: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD----EKKT 786
+E E+L K++ N L+ K + EN L++ E KT
Sbjct: 475 RDRE-----------------IEILTKEI----NKLELKISDFLDENEALRERVGLEPKT 513
Query: 787 LEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQ 846
+ D+ + +++ + ++++ + KEIE L EE DLK++ Q+ +E K+
Sbjct: 514 MIDLTEFRNSKHLKQQ-------QYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKR 566
Query: 847 RNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL---KALNEELHLQ 903
T + ++N E + + + K DL KN E + K++ + + +E L+
Sbjct: 567 SATSGLTTE--DLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLE 624
Query: 904 RINPTTVKMKSSV---FDEDKTF---VAETLEMGEVVEKD-------TTELMEKLE---- 946
R K ++ + +E+K + E L+ + ++KD T+ ++ LE
Sbjct: 625 RSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVN 684
Query: 947 -VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
+ + + L Q+ Q G L +E++ ++E S + + + I+H
Sbjct: 685 AIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLE 744
Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
E ++ S+++ + + A S S +N ++ E + + + E+S
Sbjct: 745 KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDS 804
Query: 1066 KQEQ----LILDHLPSVTKESSL--RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC 1119
++ ++ H S+ + L + T +E+ +++E L+ + ++++
Sbjct: 805 LEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNL 864
Query: 1120 LSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179
L+ + + + EN + + + E+ + Q + EL++ + E + K +
Sbjct: 865 LNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSM 924
Query: 1180 EGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED 1239
E + IG LQ+ E + + L V+ + + N + E + Y +
Sbjct: 925 EAEVCEK-IGCLQR-FKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQK 982
Query: 1240 PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR----LSKIWGQQTDGMKLEFGEE 1295
+ R + E + L + E NK L + + + W Q+T + G E
Sbjct: 983 DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQET-----KLGNE 1037
Query: 1296 NLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL-ESLISSLQQQL 1354
+ + + +TN + + ++ K + +++L + + E Q++ E L +SL+Q
Sbjct: 1038 SSMDKAKK------SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM- 1090
Query: 1355 KETEQNYE-----AEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKN 1409
E+N+E AE+ + Q V + S ++++D QR + K
Sbjct: 1091 --EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRIL---ELEKNE 1145
Query: 1410 IDGTIEFSGEFGVKEETNI----VKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465
++ +E S ++E ++I V++L Q Q + ++EV + + + AQ E S I+
Sbjct: 1146 MELKVEVSK---LREISDIARRQVEILNAQQQSR-DKEVESLRMQLLDYQAQSDEKSLIA 1201
Query: 1466 GGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF--KPLSKELGE 1523
++ S + + A + + + + +D K + + + + +
Sbjct: 1202 KLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 1261
Query: 1524 HGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLN 1583
H ++ + S + + +E FSK T I Q+ +I ++ ++
Sbjct: 1262 HLRQTIQSLRR-----QFSGALPLAQQEKFSK--TMIQLQNDKLKIMQEMKNSQQEHRNM 1314
Query: 1584 EEQLEDMR------QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL 1637
E + +M +EL+ ++ + A +++ HM+ E+L+ + +LNR+L
Sbjct: 1315 ENKTLEMELKLKGLEELISTLKDTKGAQKVINW-HMKI--------EELRLQELKLNREL 1365
Query: 1638 AQRSSIDN--ENLVSERERVL--LEELEALKQLSLAGREKLCCELRNSSTQTQNG--NEN 1691
+ N++SE ER + LEE E ++Q ++ + R + Q +
Sbjct: 1366 VKDKEEIKYLNNIISEYERTISSLEE-EIVQQNKFHEERQMAWDQREVDLERQLDIFDRQ 1424
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Q E+ K +E D + + AL+K + +I+LE T ++EE +
Sbjct: 1425 QNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENI-RIILETRATCKSLEEKLKE 1483
Query: 1752 H--VLGILDRSSKSQSSA--SLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807
L + +++ S+ L R A A + + E + + S+ +
Sbjct: 1484 KESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK--SHHTLKIAHQT 1541
Query: 1808 I-NMWSKVT--EEGTELSQRLV-RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863
I NM +++ EE + QRL+ ++ EI ++EE + + RL+ + L +
Sbjct: 1542 IANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQ 1601
Query: 1864 TSSQLEHAKVTQTEL---------MRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914
T+ L T M ++ ++ ++ SL + L++ + R RE
Sbjct: 1602 TAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVK--LKKVSQDLERQREITE 1659
Query: 1915 VELSKAEGVI----DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ---------- 1960
+++ + E + + + DE + ++++ ++D+ ++E C + LQ
Sbjct: 1660 LKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAP 1719
Query: 1961 ---------ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
L+++ +++++ LSR ++AE ++ + + L VQ
Sbjct: 1720 TTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQI 1779
Query: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
++ +L+ QV+ L ++ + + +N+ +L N L+K+ + K L E
Sbjct: 1780 VDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILRE 1839
Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVP---RFQPISEHQTREVEQLANHLKEKTDKCSEL 2128
+ + + E D +++I++L L+ P Q + E R+V++L N L+ K ++ +L
Sbjct: 1840 KE-EIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV-DL 1897
Query: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVS-ADTF---QKVEDRKHFGAVEAKPE 2184
KE+ ++ R EE +K + ++ + L + F +++ K A K +
Sbjct: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
Query: 2185 LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ--LHMQLEIQKKESTT 2242
L+L+ +L+ +D+ I LE + E EEL+ +N +++ L+M+ Q +
Sbjct: 1958 LTLQRKLKTTGMTVDQV-LGIRALESEKEL--EELKKRNLDLENDILYMRAH-QALPRDS 2013
Query: 2243 RLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2302
+++L +N+ ++ + A+++ + T + + G + ++E E+ + N +++
Sbjct: 2014 VVEDLHLQNRYLQEKLH----ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLS 2069
Query: 2303 KLQQQLKITTD--NKVIEEKNELIRDLETQIECLMSDQECVKRNR--------------- 2345
+LK + NK + +RDL+ E L ++ V+R
Sbjct: 2070 SENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPE 2129
Query: 2346 -EEEIEQLNEVIEKLQQELANI----GQKTSMNAHSLSEEADSLKHQLDVV---IAEKLA 2397
E+ I + +V+EK+Q+E + G TS ++ +E + LK +L+ + + +L+
Sbjct: 2130 LEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLS 2189
Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDH 2457
+ + +T E +N +L +EL K+E ++ EK++ I +N++ +
Sbjct: 2190 MHYESKTKGTEKIIAEN---------ERLRKEL---KKETDAAEKLR-IAKNNLEIL--- 2233
Query: 2458 LSKDKPELEVVLTEDALKSLENQ-TYFKSFEENGKGSII---NLETRLLQLESTVSAKDL 2513
+K +++ T L+ E++ + + SI+ ET+L +LE+ ++ K+
Sbjct: 2234 --NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQ 2291
Query: 2514 ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQD 2573
+T + +K+ E+ ++K+ + +E+++ L+ V E A+
Sbjct: 2292 SITDLKQLVKEATER--------EQKVNKYNEDLEQQIKI-------LKHVPEGAE---- 2332
Query: 2574 NQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQ----V 2629
E L ++ L L +L+ + E+ + K+Q
Sbjct: 2333 -------------------TEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAES 2373
Query: 2630 EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFN 2689
I + + L+++ K LE Q + EK+ ++E K+ +++E N + FF
Sbjct: 2374 TIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE-----------NFDPSFFE 2422
Query: 2690 ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKD 2732
E+E L+ + +EK +KL E+L V+ T+ + ++
Sbjct: 2423 EIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEE 2465
Score = 179 bits (454), Expect = 5e-44
Identities = 388/1983 (19%), Positives = 836/1983 (42%), Gaps = 254/1983 (12%)
Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATESLKC 1895
P EEL N+ L ++ E SE + H ++TQ+ + K +A E
Sbjct: 19 PRQEELADNLLISLSKV--EVNELKSEKQENVIHLFRITQSLM-------KMKAQEVELA 69
Query: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
EE+ + E+++ QL ++ K E ++ +++ R + + I +LE++L
Sbjct: 70 LEEVEKAGEEQAKFENQLKTKVMKLENELE--MAQQSAGGRDTRFLRNEICQLEKQLEQK 127
Query: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ---LLQETEKLMKEKLEVQCQA 2012
L+++E E ++ ++ E L+ + E + E + ++ L ++ E+L ++ ++ Q Q
Sbjct: 128 DRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQI 187
Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRF-IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
+ ++ L + + + D Q+S+ EL Q + E+ L + N+ +E Q ++MRK L+E
Sbjct: 188 DSQKETLLSR-RGEDSDYRSQLSKKNYELIQYLD-EIQTLTEANEKIEVQNQEMRKNLEE 245
Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131
+ E D + + + Q V+ + + ++H +V++L + LK K ++ ++++
Sbjct: 246 SVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVA 305
Query: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQL 2191
N ++E+ + + + ++ + ++ ++A + +
Sbjct: 306 V----------NAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDAD-----KSNV 350
Query: 2192 QAERDAIDRKEKEITNLEEQLEQFREELEN--------KNE---------EVQQLHMQLE 2234
A + I ++ +I L EQ+EQ+ +E+E KNE QQ HM+++
Sbjct: 351 MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQ 410
Query: 2235 I------QKKESTTRLQELEQENKLFKDDMEKLGLAIK-----ESDAMSTQDQHVLFGKF 2283
+K + R EL + + KD ++L A+K ES +D V
Sbjct: 411 STLDILKEKTKEAERTAELAEADAREKD--KELVEALKRLKDYESGVYGLEDAVVEIKNC 468
Query: 2284 AQIIQEKEVEIDQLNEQVTKLQQQLK-ITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2342
I+ ++ EI+ L +++ KL+ ++ +N+ + E+ L + + + +
Sbjct: 469 KNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528
Query: 2343 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE-EADSLKHQLDVVIAEKLALEQQ 2401
+ E + L + IE L++E ++ +K A + A S D+ + E ++ +
Sbjct: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588
Query: 2402 VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2461
+ ++ +KN + E K L++EL +R+ E + + +N + ++ +
Sbjct: 589 ISERKLDLLSLKN-MSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQL 647
Query: 2462 KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ 2521
+ ++ +L A+K ++ K G+ S+I + LE V+A
Sbjct: 648 EEGMKEIL--QAIKEMQKDPDVK----GGETSLI-----IPSLERLVNA----------- 685
Query: 2522 IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2581
I+ +G F+ + K V+ E++ L + + EA+ + + N I
Sbjct: 686 IESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL-RESRKEAINYSQQLAKANLKIDHLE 744
Query: 2582 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLE-KE 2640
+ T++ LR+ E GS++ + +L + S+I + + I LE KE
Sbjct: 745 KETSL-----LRQSE-GSNV---VFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKE 795
Query: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700
KKL L+ LE +K V++ L + + +E E + ES
Sbjct: 796 KKLKNLEDSLEDYNRK------------FAVIRHQQSLLYKE----YLSEKETWKTESKT 839
Query: 2701 TKAELASYKEKAEKLQEELLVKETN--MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEV 2758
K E +++ + Q+ + VKE N + +LQ D +++ LAE K+++L+ +++ +
Sbjct: 840 IKEEKRKLEDQVQ--QDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
Query: 2759 QESKKACMFEPLPIKLSKS-----IASQTDGTLKISSSNQTPQILV-KNAGIQINLQSEC 2812
++ E K ++ ++ + + KI + ++ + K A +Q + +
Sbjct: 898 RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957
Query: 2813 SSEEVTEIISQFTEKIEKMQEL---------HAAEILDMESRHIS----------ETETL 2853
S E+ Q+ E K +++ + + +E +IS E E
Sbjct: 958 SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEIT 1017
Query: 2854 KREHYVAVQLLKEE--CGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ 2911
K + + Q ++E G ++ + +S S I ++ + + ++ Q
Sbjct: 1018 KEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQ 1077
Query: 2912 GIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDH 2971
+Y H + E R E E+ F + K L A E M L +S D
Sbjct: 1078 KMY-EHLRTSLKQMEERNFELET---KFAELTKINLDAQKVEQMLRDELADSVSKAVSDA 1133
Query: 2972 SIQQVSEPWLE----ERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL 3027
Q++ E LE E K ++ + + D+ +R+ E+ ++ Q +
Sbjct: 1134 DRQRILE--LEKNEMELKVEVSKLREISDI-----ARRQVEILNAQQQSRDKEVESLRMQ 1186
Query: 3028 LALQQVFLEERSVLLAAFR-------TELTALGTTDAV--------GLLNCLEQRIQE-Q 3071
L Q +E+S++ + +E TALG +++ LEQ++ E +
Sbjct: 1187 LLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKE 1246
Query: 3072 GVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS 3131
Y A +E +A + L IQ+L Q +G + L ++++ K +L ++ Q
Sbjct: 1247 QALYYARLEGRNRA--KHLRQTIQSLRRQFSG-ALPLAQQEKFSKTMIQLQNDKLKIMQ- 1302
Query: 3132 QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEA 3191
+M Q E +M+++ E++ +L + +++ LK K+ + +K + L+EL+
Sbjct: 1303 EMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKV-INWHMKIEELRLQELKL 1361
Query: 3192 FRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLES 3251
R VKDK +E+ LN+ ++ ++ +LE+E + + E + + + LE
Sbjct: 1362 NRELVKDK-EEIKYLNNIISEYERTIS----SLEEEIVQQNKFHEERQMAWDQREVDLER 1416
Query: 3252 QKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3311
QL++ QQ ++LN +Q+ E+ + D L + L+ + E+ ++ +
Sbjct: 1417 ------QLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILET 1470
Query: 3312 MSSTLDRERELHAQ-----------LQSSDGTGQSRPPLPS----EDLLKEL-QKQLEEK 3355
++ E +L + L + R LP+ E L+ EL +K++E K
Sbjct: 1471 RATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK 1530
Query: 3356 HSRIVELLNETEKYKLDSLQTRQQ-MEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3414
+++ ++T L +++ ++K +++ K + ++E + ++ +H L ++E
Sbjct: 1531 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLE- 1589
Query: 3415 LQRQLEEKRQQVYKLDLEGQRLQGI--------MQEFQKQELEREEKRESRRILYQNLNE 3466
LQ + + DL Q + + E ++ E+++ S + + +++
Sbjct: 1590 LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ 1649
Query: 3467 --PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVAS 3524
+T + + + + I+ + +E++ ++ ++ + L+ +++ QC+ S
Sbjct: 1650 DLERQREITELKVKEF---ENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKS 1706
Query: 3525 KLQVLPQKAS-----------ERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPS 3573
+LQ + S ERL+ + A E Q+ + +L+L+ EE
Sbjct: 1707 ELQAQKEANSRAPTTTMRNLVERLKSQLALKEK---QQKALSRALLELRAEMTAAAEERI 1763
Query: 3574 LVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNS 3633
+ S S E L + H +L + DL ++KL+E ++ T R+NS
Sbjct: 1764 I-----SATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALK----TSKNRENS 1814
Query: 3634 SRFSLNGGAN-------IEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLL 3686
+LN N I EKE ++E L++ +KR + + SL+
Sbjct: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLI 1874
Query: 3687 QTL 3689
+ L
Sbjct: 1875 EEL 1877
Score = 176 bits (447), Expect = 3e-43
Identities = 519/2690 (19%), Positives = 1099/2690 (40%), Gaps = 448/2690 (16%)
Query: 932 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSL-KQEKEQV 990
E+++ D +L + E+ + LS+ +++E +K + L +SL K + ++V
Sbjct: 9 EIMKVDPDDLPRQEELADNLLISLSK--VEVNELKSEKQENVIHLFRITQSLMKMKAQEV 66
Query: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKV--NKSFGEESKI 1048
L E+E +A+ T+V L + + M + A G ++ N+ E ++
Sbjct: 67 ELALEEVEKA-GEEQAKFENQLKTKVMKL-ENELEMAQQSAGGRDTRFLRNEICQLEKQL 124
Query: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108
+D+ E+M +E ++E+ + + L +E+ +EN KL++E +
Sbjct: 125 EQKDR-ELEDME--KELEKEKKVNEQLALRNEEAE------NENSKLRRE---------N 166
Query: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL- 1167
RL+ + +++C ++ ++ ++++K+ L E+ + + K + I L
Sbjct: 167 KRLKKKNEQLCQDII------DYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLD 220
Query: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
E+QT+ + + + + +++K + E +Q + + EY +K V+ D
Sbjct: 221 EIQTLT-----EANEKIEVQNQEMRKNLEES----VQEMEKMTDEYNR--MKAIVHQTD- 268
Query: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287
N D + + D Y+ +VQ+ + LL EE + ++V
Sbjct: 269 -NVIDQLKKEND----HYQLQVQELTD----LLKSKNEEDDPIMVAVNA----------- 308
Query: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQ-DLEKTK---LEEQVQEL 1343
K+E + L ++ E + + NL + KL + Q D +K+ L++ +QE
Sbjct: 309 -KVEEWKLILSSKDDEIIEYQQMLHNLRE-------KLKNAQLDADKSNVMALQQGIQER 360
Query: 1344 ESLISSLQQQLKETEQNYEAE---IHCLQKRLQ------AVSEST-VPPSLPVDSVVITE 1393
+S I L +Q+++ + E I L+ LQ +S+ T + +D +
Sbjct: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420
Query: 1394 SDAQRTMYPGSCVKKNIDGTIEF---------SGEFGVKEETNIVKLLEKQYQ------E 1438
+A+RT + D + SG +G+++ +K + Q + E
Sbjct: 421 KEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE 480
Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGGKE-----NTASSKQAHAVCQQEQHYFNEMKL 1493
L +E+ K+ + +S F + E R G E + + + + QQ+ N++ L
Sbjct: 481 ILTKEINKLELKIS-DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILL 539
Query: 1494 SQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553
+ ++ E + K++ + +++E G+ L+ D + + E+ ISE
Sbjct: 540 KE----IESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLN-LTENISQGDRISERKL 594
Query: 1554 S--KDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQA 1611
K QS ++ +S ++ R L + + + +L +E++Q E +++
Sbjct: 595 DLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEI 654
Query: 1612 HMRQMERQREDQEQLQEE---IKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS- 1667
E Q++ + E I L R + ++I+++N E + L Q+
Sbjct: 655 LQAIKEMQKDPDVKGGETSLIIPSLERLV---NAIESKNA----EGIFDASLHLKAQVDQ 707
Query: 1668 LAGR-EKLCCELRNSSTQTQNGNENQGEVE---EQTFKEKELDRKPE---------DVPP 1714
L GR E+L ELR S + N ++ + + KE L R+ E D+P
Sbjct: 708 LTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPD 767
Query: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774
I + + N L+ +L E+ ++ L+ S + + + R +
Sbjct: 768 GIAPSSASIINSQNEYLIHLLQELENKEKKLKN---------LEDSLEDYNRKFAVIRHQ 818
Query: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834
K + E+ T T+ + EE +L ++ + E
Sbjct: 819 QSLLYKEYLSEKETWKTESKT------------------IKEEKRKLEDQVQQDAIKVKE 860
Query: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRE---------SFRQ 1885
+ N+ + LQ +++ + ++E S ++ +V + L+R+ R+
Sbjct: 861 YN--------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRK 912
Query: 1886 KQEA--TESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD--EKTLFERQIQEK 1941
+ E E L + E+ E++ R +E +++ + V+D E L +Q E
Sbjct: 913 ENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNEL 972
Query: 1942 T----DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE 1997
T DI+ + + L+ ++ L+ LE E ++E+ E ++++ E K + +EQ QE
Sbjct: 973 TAKYRDILQK-DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQE 1031
Query: 1998 TEKLMKEKLEVQCQAEKVRDDL---QKQVKALE---IDVEEQVSRFIELEQEKNTELMDL 2051
T KL E + + D+ K++ LE ++ ++ ++ + T L +
Sbjct: 1032 T-KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM 1090
Query: 2052 RQQNQALEKQLEKMRKF-LDEQAID---REHERDVFQQ-----------EIQKLEQQLKV 2096
++N LE + ++ K LD Q ++ R+ D + E++K E +LKV
Sbjct: 1091 EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKV 1150
Query: 2097 -VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
V + + IS+ R+VE +L+ +Q RD + + ++ L+++ +
Sbjct: 1151 EVSKLREISDIARRQVE----------------ILNAQQQSRDKEVESLRMQLLDYQAQS 1194
Query: 2156 LEQALLVSADTFQ---KVEDRKHFGAVEA------KPE---LSLEVQLQAERDAIDRKEK 2203
E++L+ ++ + G +E+ K E L LE +L + A+
Sbjct: 1195 DEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARL 1254
Query: 2204 EITNLEEQLEQFREELENK---------NEEVQQLHMQLEIQKKESTTRLQELEQENKLF 2254
E N + L Q + L + E+ + +QL+ K + ++ +QE++
Sbjct: 1255 EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNM 1314
Query: 2255 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2314
++ ++ L +K + + + + K AQ + ++I++L Q KL ++L D
Sbjct: 1315 ENKTLEMELKLKGLEELISTLKDT---KGAQKVINWHMKIEELRLQELKLNREL--VKDK 1369
Query: 2315 KVIEEKNELIRDLETQIECLMSDQECVKRN------------REEEIEQLNEVIEKLQQE 2362
+ I+ N +I + E I L ++E V++N RE ++E+ ++ ++ Q E
Sbjct: 1370 EEIKYLNNIISEYERTISSL--EEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNE 1427
Query: 2363 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422
+ N QK S+ + + L +QL++ + + +++ + ++ ET
Sbjct: 1428 ILNAAQKFEEATGSIPDPSLPLPNQLEIALRK---IKENIR-----------IILETRAT 1473
Query: 2423 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP---ELEVVLTEDALKSLEN 2479
L ++L +E+ES ++ S + I+ L P E E ++ E K +E
Sbjct: 1474 CKSLEEKL----KEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP 1529
Query: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
+++ + +I N++ RL Q E + K+ + + E+ + E + KK
Sbjct: 1530 KSHHTL--KIAHQTIANMQARLNQKEEVL-----------KKYQRLLEKAREEQREIVKK 1576
Query: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS 2599
E+ L +++L+A KF Q + + N + +R E+
Sbjct: 1577 --------HEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ 1628
Query: 2600 DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659
++ +S L ++ ++ L + Q EI E V E E L+LQ+ E
Sbjct: 1629 TVAEQDDSLSSLLVKLKKVSQDL---ERQREITELKVKEFENIKLQLQE--------NHE 1677
Query: 2660 KEKKRSPQDVEVLKTTTELFHSNEESGFF-NELEALRAESVATKAELASYKEKAEKLQEE 2718
E K+ +VE LK + S +ES +EL+A + + ++A + + E+L+ +
Sbjct: 1678 DEVKKVKAEVEDLKYLLD--QSQKESQCLKSELQAQKEAN--SRAPTTTMRNLVERLKSQ 1733
Query: 2719 LLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL---EKEDETEVQESKKACMFEPLPIKLS 2775
L +KE +L + L ++R + A E+ I +KE VQ+ + + +L
Sbjct: 1734 LALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ-----IVDRHTRELK 1788
Query: 2776 KSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQE-- 2833
+ + LK+ + +T S+ +T+ ++ +++K Q+
Sbjct: 1789 TQVEDLNENLLKLKEALKT---------------SKNRENSLTDNLNDLNNELQKKQKAY 1833
Query: 2834 ---LHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELA 2890
L E +D E+ + L + ++ + + ++ E ++
Sbjct: 1834 NKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVE 1893
Query: 2891 HSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG---RGEESESATDSFPKKIKGLL 2947
D +E + + W +G + + EG + +E E + K++ L
Sbjct: 1894 EVDLKPMKEKNAKEELIRWEEG------KKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLK 1947
Query: 2948 RAVHNEGMQVLSLTESPYSDGEDHSIQQV-------SEPWLEE-RKAYINTISSLKDLIT 2999
+ L+L + G ++ QV SE LEE +K ++ + + +
Sbjct: 1948 DLFAKADKEKLTLQRKLKTTGM--TVDQVLGIRALESEKELEELKKRNLDLENDILYMRA 2005
Query: 3000 KMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVG 3059
L R++ V D + E L AL++ F ++ + ++ + + D
Sbjct: 2006 HQALPRDSVVEDLHLQNRYLQ----EKLHALEKQFSKD-----TYSKPSISGIESDDHCQ 2056
Query: 3060 LLNCLEQ---RIQEQGVEYQAAMECLQKADRRSLLSEIQAL------------------- 3097
L++ ++ + +E + +E K D L ++++ L
Sbjct: 2057 REQELQKENLKLSSENIELKFQLEQANK-DLPRLKNQVRDLKEMCEFLKKEKAEVQRKLG 2115
Query: 3098 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3157
H + +GR E E + + +Q++ Q+ + L+S ++ ++++
Sbjct: 2116 HVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS--EKMANIEQENEKL 2173
Query: 3158 KMVVAELKSELA-QTKLELETTLKAQHKHLKELEAFRLEVKDKTD----------EVHLL 3206
K + +LK+ L Q + E+ K K + E E R E+K +TD + +L
Sbjct: 2174 KAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEIL 2233
Query: 3207 NDTLASE-QKKSRELQWA------LEKEKAKLGRS---EERDKEELEDLKFSLESQKQRN 3256
N+ + + ++ + LQ+A LE +K +S + +L++L+ + + Q
Sbjct: 2234 NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSI 2293
Query: 3257 LQLNLLLE---QQKQLLNESQQKIESQRML---YDAQLSEEQGRNLELQVLLESEKVRIR 3310
L L++ +++Q +N+ + +E Q + EQG ELQVL R
Sbjct: 2294 TDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVL--------R 2345
Query: 3311 EMSSTLDRER-ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY 3369
+ LD+E+ EL Q++++ + +P D LKE K LE + ++ +L E +
Sbjct: 2346 LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQ-LKMSDL--EKQHL 2402
Query: 3370 KLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQL 3419
K + + ++++E + ++ + E KK L+ KV+ L QL
Sbjct: 2403 KEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
Score = 176 bits (447), Expect = 3e-43
Identities = 460/2455 (18%), Positives = 1011/2455 (41%), Gaps = 350/2455 (14%)
Query: 492 NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551
N+ I+ +++ + S+K++ L I + ++ Q E+ + E++++A +
Sbjct: 27 NLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQ------EVELALEEVEKAGEEQ 80
Query: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
A+ E++L + V L+ E+ A +S + + + N +LE ++K+ L
Sbjct: 81 AKFENQLK------TKVMKLENELEMAQQSAGGRDTRF---LRNEICQLEKQLEQKDREL 131
Query: 612 DRMAESQEAELERLRTQLLFSHEE---ELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
+ M + E E +++ QL +EE E SKL+ + + + N + +D I Y++QID
Sbjct: 132 EDMEKELEKE-KKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI--IDYQKQID 188
Query: 669 GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728
+K+ L++++ + S+L L+ E TL E ++I
Sbjct: 189 S--------------QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTL--TEANEKI 232
Query: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE 788
E+ QE ++ LE+ VQE++ T+ + MK + QL+ EN + + + L
Sbjct: 233 EVQNQEMRKN--LEESVQEMEKMTDEYNR-MKAIVHQTDNVIDQLKKENDHYQLQVQELT 289
Query: 789 DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRN 848
D+LK EE + ++ +K ++ W+ IL +++++ + L+ EK +N
Sbjct: 290 DLLKS----KNEEDDPIMVAVNAKVEE--WKL---ILSSKDDEIIEYQQMLHNLREKLKN 340
Query: 849 TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
A+K+ + Q+ +E +K+ + + K+ + ++ L EL
Sbjct: 341 AQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRN----- 395
Query: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ 968
K S++ + + TL++ + K+ E E REK + L + ++LK
Sbjct: 396 --KGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREK---DKELVEALKRLKD 450
Query: 969 KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTS 1028
+ L + V +K K Q+ +R RE+EI+ + + + ++S LD +
Sbjct: 451 YESGVYGLEDAVVEIKNCKNQIKIRDREIEIL-----TKEINKLELKISDFLDENEALRE 505
Query: 1029 RGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQ-EQLILDHLPSVTKESSLRAT 1087
R + ++ + SK + + + EN + +E + E+ LD + + + R
Sbjct: 506 RVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGK 565
Query: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147
+ + + ++LN+ ++ R+ E + LSL + E+ L
Sbjct: 566 RSATSGLTTEDLNLTENISQGDRIS-ERKLDLLSLKNMSEAQSKNEF-----------LS 613
Query: 1148 EELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206
ELI EK ++L++ + + K +E +E K L + ++ +A+ E +Q
Sbjct: 614 RELI----EKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE-----MQKD 664
Query: 1207 CSVLG---EYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKV 1263
V G P+L+ VNA + +N+ D L + +V L ++
Sbjct: 665 PDVKGGETSLIIPSLERLVNAIESKNAEGIF----DASLH-LKAQVDQLTGRNEELRQEL 719
Query: 1264 TEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-ENLPKEETEFLSIHSQMTNLEDIDVNHK 1322
E + + +L+K +K++ E E ++E ++ + +L D
Sbjct: 720 RESRKEAINYSQQLAKA------NLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSS 773
Query: 1323 SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPP 1382
+ + + Q+ L ++++ E + +L+ L++ + + H Q+ L +
Sbjct: 774 ASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRH--QQSLLYKEYLSEKE 831
Query: 1383 SLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442
+ +S I E K+ ++ ++ VKE N++ L+ +
Sbjct: 832 TWKTESKTIKEE------------KRKLEDQVQ-QDAIKVKEYNNLLNALQMD-----SD 873
Query: 1443 EVAKVIV--SMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQ-DQIG 1499
E+ K++ S I Q E S I +Q +++++ M+ ++IG
Sbjct: 874 EMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIG 933
Query: 1500 -FQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558
Q F+ + + FK + E+ L+N +++ ++ KD
Sbjct: 934 CLQRFKEMAI-FKIAALQKVVDNSVSLSELELANKQYNELTAKY-------RDILQKDNM 985
Query: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
+ R S + + ++ Q+ ++LE +++L Q +Q T+L ++ M + ++
Sbjct: 986 LVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKK 1045
Query: 1619 Q--REDQEQLQEEIKRLN-RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLC 1675
D + ++I L ++L +R ++ + E R L+++E
Sbjct: 1046 SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE------------- 1092
Query: 1676 CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735
RN +T+ + ++ Q ++ D + V + +R + + +++
Sbjct: 1093 ---RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELK 1149
Query: 1736 LEVVKTTAAVEETIGRHVLGILDRSSKS-----QSSASLIWRSEAEASVKSCVHEEHTRV 1790
+EV K + I R + IL+ +S +S + +A++ KS + + H
Sbjct: 1150 VEVSKLREISD--IARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHN 1207
Query: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRL 1850
+ + + + K+ L Q+L E E+ +
Sbjct: 1208 VSLQLSEATALGKLESITSKLQKMEAYNLRLEQKL-----------DEKEQALYYARLEG 1256
Query: 1851 QAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRA 1909
+ + L + I Q A + Q E ++ Q Q + LK +E++ E
Sbjct: 1257 RNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN--DKLKIMQEMKNSQQEHRNM 1314
Query: 1910 RE---QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQ 1966
++ ++L E +I D K Q+++ +++EL ++
Sbjct: 1315 ENKTLEMELKLKGLEELISTLKDTKGA----------------QKVINWHMKIEELRLQE 1358
Query: 1967 QQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKAL 2026
++ E L + KE +K ++ E E+ + E Q K ++ Q
Sbjct: 1359 LKLNRE---LVKDKEEIK-----YLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQR 1410
Query: 2027 EIDVEEQVSRFIELEQEKNTELMDLRQQNQALE--KQLEKMRKFLDEQAIDREHERDVFQ 2084
E+D+E Q+ F RQQN+ L ++ E+ + + ++ ++ ++
Sbjct: 1411 EVDLERQLDIFD-------------RQQNEILNAAQKFEEATGSIPDPSLPLPNQLEI-- 1455
Query: 2085 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 2144
++K+++ ++++ E L+EK + L EQ +I R++
Sbjct: 1456 -ALRKIKENIRII-----------LETRATCKSLEEKLKEKESALRLAEQ---NILSRDK 1500
Query: 2145 EIEKLEFRV-RELEQALLVSADTFQKVEDRKHFGAVEAKPELS-LEVQLQAERDAIDRKE 2202
I +L R+ E+ L++ +++E + H A ++ ++ +L + + + + +
Sbjct: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
Query: 2203 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE-----------N 2251
+ LE+ E+ RE ++ E++ LH +LE+Q S + ++ + N
Sbjct: 1561 RL---LEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTN 1617
Query: 2252 KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ--EKEVEIDQLN-EQVTKLQQQL 2308
K F E ++ D++S+ L K ++ Q E++ EI +L ++ ++ QL
Sbjct: 1618 KHFIRLAEMEQTVAEQDDSLSS-----LLVKLKKVSQDLERQREITELKVKEFENIKLQL 1672
Query: 2309 KITTDNKV------IEEKNELIRDLETQIECLMSDQECVK-----------RN------- 2344
+ +++V +E+ L+ + + +CL S+ + K RN
Sbjct: 1673 QENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKS 1732
Query: 2345 ----REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400
+E++ + L+ + +L+ E+ ++ ++A S E +++ +D E L+
Sbjct: 1733 QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRE---LKT 1789
Query: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460
QVE NE + +K LK + + N LT L L E + +K N + + + +
Sbjct: 1790 QVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY----NKILREKEEIDQ 1845
Query: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
+ EL + +K L + K +N + I L+ ++ +LE+ + K E+
Sbjct: 1846 ENDEL-----KRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPM 1900
Query: 2521 QIKDMQEQ--GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQE-YAKFCQDNQTI 2577
+ K+ +E+ E + Q KI ++ ++EK QL +++ +AK ++ T+
Sbjct: 1901 KEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTL 1960
Query: 2578 SSEPERT--NIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKN 2635
+ + T + + +R E ++ L R +LE+ ++ M L ++ V + + +
Sbjct: 1961 QRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSV-VEDLH 2019
Query: 2636 VLEK--EKKLLELQKL-------------LEGNEKKQREKEKKRSPQDVEVLKTTTELFH 2680
+ + ++KL L+K +E ++ QRE+E ++ E LK ++E
Sbjct: 2020 LQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQK-----ENLKLSSE--- 2071
Query: 2681 SNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH- 2739
N E F +LE + K ++ KE E L++E +Q+ L VR
Sbjct: 2072 -NIELKF--QLEQANKDLPRLKNQVRDLKEMCEFLKKE-------KAEVQRKLGHVRGSG 2121
Query: 2740 -----LAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQT 2794
+ E ++ + +++K E +E+++ + + I S+ +A+ K+ + +
Sbjct: 2122 RSGKTIPELEKTIGLMKKVVEKVQRENEQ--LKKASGILTSEKMANIEQENEKLKAELEK 2179
Query: 2795 PQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK--MQELHAAEILDMESRHI 2847
L + G Q+++ E ++ +II++ E++ K +E AAE L + ++
Sbjct: 2180 ---LKAHLGHQLSMHYESKTKGTEKIIAE-NERLRKELKKETDAAEKLRIAKNNL 2230
Score = 171 bits (434), Expect = 1e-41
Identities = 447/2333 (19%), Positives = 936/2333 (40%), Gaps = 369/2333 (15%)
Query: 1584 EEQLEDMRQELVRQYQEHQQA-----TELLR------QAHMRQMERQREDQEQLQEEIKR 1632
E QL+ +L + + QQ+ T LR + + Q +R+ ED E+ E+ K+
Sbjct: 84 ENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKK 143
Query: 1633 LNRQLAQRS-SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
+N QLA R+ +NEN RE L++ E+LC Q+ +
Sbjct: 144 VNEQLALRNEEAENENSKLRRENKRLKK----------KNEQLC----------QDIIDY 183
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Q +++ Q KE L R+ ED S+ R L K N L++ L E+ T A E+
Sbjct: 184 QKQIDSQ--KETLLSRRGED------SDYRSQLSKKNYELIQYLDEIQTLTEANEKI--- 232
Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE------------EHTRVTDESIPSYS 1799
V R + +S + ++ +K+ VH+ +H ++ + +
Sbjct: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292
Query: 1800 GSDMPRND---------INMW----SKVTEEGTELSQRL--VRSGFAGTEIDPENEELML 1844
S +D + W S +E E Q L +R ++D + +M
Sbjct: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMA 352
Query: 1845 ---NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEAT----------- 1890
I R + ++ L E + + + ++E +L E R K +T
Sbjct: 353 LQQGIQER-DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411
Query: 1891 ------ESLKCQEELRERLHEESRAREQLAVELSK--------AEGVIDGYADEKT---- 1932
E K E E ++R +++ VE K G+ D + K
Sbjct: 412 TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQ 471
Query: 1933 --LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL-----SRQKEAMKA 1985
+ +R+I+ T I++LE ++ S+ L E EA ++++ E + + R + +K
Sbjct: 472 IKIRDREIEILTKEINKLELKI---SDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528
Query: 1986 EAGPVEQQ-LLQETEKLMKEKLEVQCQAEKVRDDLQKQ-----VKALEIDVEEQVSRFIE 2039
+ E Q LL+E E L +E+L+++ + ++ + K+ + ++++ E +S+
Sbjct: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588
Query: 2040 LEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPR 2099
+ E+ +L+ L+ ++A K +FL + I++E + + + I K + +LK +
Sbjct: 589 I-SERKLDLLSLKNMSEAQSK-----NEFLSRELIEKERDLERSRTVIAKFQNKLKELVE 642
Query: 2100 FQPISEHQTREVEQLANHLKEKTD----KCSELLLSKEQLQRDIQERNEE---------- 2145
E +E+ Q +++ D + S ++ S E+L I+ +N E
Sbjct: 643 ENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLK 702
Query: 2146 --IEKLEFRVRELEQALLVS---ADTFQKVEDRKHFGAVEAKPELSLEVQ---------- 2190
+++L R EL Q L S A + + + + + E SL Q
Sbjct: 703 AQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKG 762
Query: 2191 --------------LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2236
+ ++ + + +E+ N E++L+ + LE+ N + + Q +
Sbjct: 763 IDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLL 822
Query: 2237 KKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
KE + + + E+K K++ KL +++ DA+ ++ + L E + + +
Sbjct: 823 YKEYLSEKETWKTESKTIKEEKRKLEDQVQQ-DAIKVKEYNNLLNALQMDSDEMKKILAE 881
Query: 2297 LNEQVTKLQQQLK--ITTDNKVIEEKNELIRDLETQIECLMSDQE-------CVKRNRE- 2346
+ ++T LQ K I ++E + +L ++ E Q L+S + C++R +E
Sbjct: 882 NSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEM 941
Query: 2347 ------------------EEIEQLNEVIEKLQQELANIGQKTSMNAH------------- 2375
E+E N+ +L + +I QK +M
Sbjct: 942 AIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENI 1001
Query: 2376 SLSEEADSLKHQLDVVIAEKL-----ALEQQVETANEEMTFMKNVLKETNFKMNQLTQEL 2430
SL E+ +S+ +L++ EKL A EQ+ + NE + K TN + +++++
Sbjct: 1002 SLKEQVESINKELEIT-KEKLHTIEQAWEQETKLGNES-SMDKAKKSITNSDIVSISKKI 1059
Query: 2431 FSLK----RERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ------ 2480
L+ ER+ E Q + E+ + ++ + + ELE E +L+ Q
Sbjct: 1060 TMLEMKELNERQRAEHCQKMYEH-LRTSLKQMEERNFELETKFAELTKINLDAQKVEQML 1118
Query: 2481 ------TYFKSFEENGKGSIINLETRLLQLESTVS--AKDLELTQCYKQIKDMQEQGQ-F 2531
+ K+ + + I+ LE ++L+ VS + ++ + +I + Q+Q +
Sbjct: 1119 RDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDK 1178
Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
E E L+ ++++ Q +EK A + Q + A ++I+S+ ++ NL
Sbjct: 1179 EVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLR- 1237
Query: 2592 LREDELGSDISALTLRISELESQVVEMHTSL---------ILEKEQVEIAEKNVLEKEKK 2642
E +L AL E ++ + ++ L Q E K +++ +
Sbjct: 1238 -LEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQND 1296
Query: 2643 LLELQKLLEGNEKKQREKEKKRSPQDV------EVLKTTTELFHSNEESGFFNELEALRA 2696
L++ + ++ ++++ R E K ++ E++ T + + + + ++E LR
Sbjct: 1297 KLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRL 1356
Query: 2697 ESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2756
+ + EL KE+ + L + E ++SL++++ Q E + D+
Sbjct: 1357 QELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAW------DQR 1410
Query: 2757 EVQESKKACMFE-------PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQ 2809
EV ++ +F+ K ++ S D +L + + + +K I+I L+
Sbjct: 1411 EVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKE-NIRIILE 1469
Query: 2810 SECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE--- 2866
+ + + + E + + + ++ + + + T +RE +A KE
Sbjct: 1470 TRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP 1529
Query: 2867 -ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIAS 2925
TLK Q + + + + YQ + + + I H + I
Sbjct: 1530 KSHHTLKIAHQTIANMQARLNQKEEVLKKYQR----LLEKAREEQREIVKKHEEDLHILH 1585
Query: 2926 EGRGEESESATDSFPKKIKGLLR-----AVHNEGMQVLSLTESPYSDGEDH------SIQ 2974
+++S+ + F + L++ N+ L+ E ++ +D ++
Sbjct: 1586 HRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLK 1645
Query: 2975 QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF 3034
+VS+ +R+ + +++ ++Q E EV E + LL Q
Sbjct: 1646 KVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL-----KYLLDQSQ-- 1698
Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI 3094
+E L + + + A + N +E R++ Q A E QKA R+LL
Sbjct: 1699 -KESQCLKSELQAQKEANSRAPTTTMRNLVE-RLKSQ----LALKEKQQKALSRALLELR 1752
Query: 3095 QALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQL 3154
+ A R I+ ++E+ Q++++ + + E++ ++ + + +L+E L
Sbjct: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTR-------ELKTQVEDLNENLLKLKEAL 1805
Query: 3155 SSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ 3214
+ K L L EL+ KA +K L+E E E + ++ L L +
Sbjct: 1806 KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKP 1865
Query: 3215 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3274
+ Q +E+ + K+ + E + + ++E++ L+ K++N + L+ ++ + + Q
Sbjct: 1866 LTDNK-QSLIEELQRKVKKLENQLEGKVEEV--DLKPMKEKNAKEELIRWEEGK---KWQ 1919
Query: 3275 QKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRER-ELHAQLQSSDGTG 3333
KIE R +L E++G L L + ++++ + D+E+ L +L++ TG
Sbjct: 1920 AKIEGIR----NKLKEKEGEVFTLTKQLNT----LKDLFAKADKEKLTLQRKLKT---TG 1968
Query: 3334 QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3393
+ + L E +K+LEE R ++L N+ + ++ Q + +D V LQ
Sbjct: 1969 MTVDQVLGIRAL-ESEKELEELKKRNLDLEND-----ILYMRAHQALPRDSVVEDLHLQN 2022
Query: 3394 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREE 3452
LQ K+ L++Q + + +E QE QK+ L+
Sbjct: 2023 RY------------LQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSS 2070
Query: 3453 KRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHEL 3512
+ + + N+ R +N V K E + A++ G G
Sbjct: 2071 ENIELKFQLEQANKDL------PRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSG 2124
Query: 3513 EMIRQKLQCVASKLQVLPQKASERLQFETAD----DEDFIWVQENIDEIILQLQKLTGQQ 3568
+ I + + + +V+ + E Q + A E +++ +++ +L+KL
Sbjct: 2125 KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHL 2184
Query: 3569 GEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLR----NMVMKLEEQIRWYR 3624
G + S+ S + G TE+++ +N L + + T+ LR N+ + E+
Sbjct: 2185 GHQLSMHYESKTKG--TEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLE 2242
Query: 3625 QTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLT--LQKSLKRAEAEVYK 3675
+TG +F+ + G +E ++ + W +T + LK E ++ K
Sbjct: 2243 ETG----KRLQFAESRGPQLE---GADSKSWKSIVVTRMYETKLKELETDIAK 2288
Score = 165 bits (418), Expect = 7e-40
Identities = 484/2440 (19%), Positives = 978/2440 (40%), Gaps = 396/2440 (16%)
Query: 1331 LEKTKLEEQVQELESLISSLQQQLKETEQ----NYEAE-----IHCLQKRLQAVSESTVP 1381
LEK +LE++ +ELE + L+++ K EQ N EAE + KRL+ +E
Sbjct: 120 LEK-QLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQ 178
Query: 1382 PSLPVDSVVITESDA------QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNI-VKLLEK 1434
+ + ++ + + + Y KKN + I++ E E N +++ +
Sbjct: 179 DIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYE-LIQYLDEIQTLTEANEKIEVQNQ 237
Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494
+ ++ LEE V ++ ++ T + A+ Q + +++K
Sbjct: 238 EMRKNLEESVQEM--------------------EKMTDEYNRMKAIVHQTDNVIDQLKKE 277
Query: 1495 QDQIGFQTFETVDV--KFKEEFKPLSKELGEHGKE--ILLSNSDPHDIPESKDCVLTISE 1550
D Q E D+ EE P+ + +E ++LS+ D +I E + + + E
Sbjct: 278 NDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDD-EIIEYQQMLHNLRE 336
Query: 1551 EMFS------KDKTFIVRQSIHDEISVSSM------DASRQLMLNEEQLEDMRQELVRQY 1598
++ + K ++Q I + S M ++++ N +ED++ EL
Sbjct: 337 KLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNEL---- 392
Query: 1599 QEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLE 1658
Q ++ A+ L +Q HM+ + + L+E+ K A+R++ E E+++ L+E
Sbjct: 393 QRNKGASTLSQQTHMKI----QSTLDILKEKTKE-----AERTAELAEADAREKDKELVE 443
Query: 1659 ELEALK--QLSLAGREKLCCELRNSSTQTQNGNE---------NQGEVEEQTF-KEKELD 1706
L+ LK + + G E E++N Q + + N+ E++ F E E
Sbjct: 444 ALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEAL 503
Query: 1707 RKPEDVPPEIL------SNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
R+ + P+ + N ++ Q+ +ILL+ +++ + + + +
Sbjct: 504 RERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820
K +++ L + + ++ + + R+++ + S +M ++ E E
Sbjct: 564 GKRSATSGL---TTEDLNLTENI-SQGDRISERKLDLLSLKNMSEAQSKN-EFLSRELIE 618
Query: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880
+ L RS + + +EL+ + +L+ ++++L+AI E + K +T L+
Sbjct: 619 KERDLERSRTVIAKFQNKLKELVEE-NKQLEEGMKEILQAIKEMQKDPD-VKGGETSLII 676
Query: 1881 ESFRQKQEATES------------LKCQ--------EELRERLHEESRAREQLAVELSKA 1920
S + A ES LK Q EELR+ L E + + +L+KA
Sbjct: 677 PSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKA 736
Query: 1921 EGVIDGYADEKTLFERQ----------------IQEKTDIIDRLEQELLCASNRLQELEA 1964
ID E +L + II+ + L+ L+ E
Sbjct: 737 NLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEK 796
Query: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ-- 2022
+ + +++ E +R+ ++ + + ++ L E E E ++ + K+ D +Q+
Sbjct: 797 KLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAI 856
Query: 2023 --------VKALEIDVEE------QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKF 2068
+ AL++D +E + SR I + Q L+ LE+QL K +
Sbjct: 857 KVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEK 916
Query: 2069 LDEQAIDREHE--------RDVFQQEIQKLEQQLKVVPRFQPISEHQT------------ 2108
+ + E E + + I K+ KVV +SE +
Sbjct: 917 QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKY 976
Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV------ 2162
R++ Q N L ++T L L+ ++ N+E+E + ++ +EQA
Sbjct: 977 RDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGN 1036
Query: 2163 --SADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE--- 2217
S D +K ++ K + LE++ ER + +K +L L+Q E
Sbjct: 1037 ESSMDKAKKSITNSDIVSISKKITM-LEMKELNERQRAEHCQKMYEHLRTSLKQMEERNF 1095
Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
ELE K E+ +++ L+ QK E R + + +K D + L +++++ +
Sbjct: 1096 ELETKFAELTKIN--LDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNE----MELK 1149
Query: 2278 VLFGKFAQI--IQEKEVEIDQLNEQ-----VTKLQQQLKITTDNKVIEEKNELIRDL-ET 2329
V K +I I ++VEI +Q V L+ QL D + ++ LI L +
Sbjct: 1150 VEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQL---LDYQAQSDEKSLIAKLHQH 1206
Query: 2330 QIECLMSDQECVKR-----NREEEIE----QLNEVIEKLQQELANIGQKTSMNAHSLSEE 2380
+ +S+ + + ++ +++E +L + +++ +Q L + A L +
Sbjct: 1207 NVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQT 1266
Query: 2381 ADSLKHQLDVVIA----------------EKLALEQQVETANEEMTFMKNVLKETNFKMN 2424
SL+ Q + +KL + Q+++ + +E M+N E K+
Sbjct: 1267 IQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLK 1326
Query: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPEL-EVVLTEDALKSLENQTYF 2483
L +EL S ++ + +K+ + H+ ++ L E+ L + +K E Y
Sbjct: 1327 GL-EELISTLKDTKGAQKVINW----------HMKIEELRLQELKLNRELVKDKEEIKYL 1375
Query: 2484 KSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2543
+ + +I +LE ++Q + + Q +++ ++ F+ + Q +I+N
Sbjct: 1376 NNIISEYERTISSLEEEIVQQNKFHEERQMAWDQ--REVDLERQLDIFDRQ--QNEILNA 1431
Query: 2544 QKIVEEKVAAALVSQIQLEAVQEYA-KFCQDNQTISSEPERTNIQNLNQLREDE------ 2596
+ EE + + L E A + ++N I E T +L+E E
Sbjct: 1432 AQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491
Query: 2597 ----LGSD--ISALTLRI---SELESQVVEM---------HTSLILEKEQVEIAEKNVLE 2638
L D I+ L LR+ +E E + E+ H +L + + + + + +
Sbjct: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ 1551
Query: 2639 KEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAES 2698
KE+ L + Q+LLE ++QRE KK +D+ +L EL + + F L +S
Sbjct: 1552 KEEVLKKYQRLLEKAREEQREIVKKHE-EDLHILHHRLELQADSSLNKFKQTAWDLMKQS 1610
Query: 2699 VATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET-- 2756
T + + ++++ + ++ +++SL L +V L +E + KE E
Sbjct: 1611 -PTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIK 1669
Query: 2757 -EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSE 2815
++QE+ + ++ K A D + S + Q L ++ Q E +S
Sbjct: 1670 LQLQENHED--------EVKKVKAEVEDLKYLLDQSQKESQCLKS----ELQAQKEANSR 1717
Query: 2816 EVTEIISQFTEKI-------EKMQELHAAEILDM--------ESRHISETETLKREHYVA 2860
T + E++ EK Q+ + +L++ E R IS T K H
Sbjct: 1718 APTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQ-KEAHLNV 1776
Query: 2861 VQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQG 2920
Q++ LK ++ L L S + RE +D+ +D +
Sbjct: 1777 QQIVDRHTRELKTQVEDLNENLLKLKEALKTS---KNRENSLTDNLNDLNNELQKKQKAY 1833
Query: 2921 FDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED--HSIQQVSE 2978
I E EE + D ++IK L G+Q LT++ S E+ ++++ E
Sbjct: 1834 NKILREK--EEIDQENDELKRQIKRL-----TSGLQGKPLTDNKQSLIEELQRKVKKL-E 1885
Query: 2979 PWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESF----SDWRGEL------LL 3028
LE + ++ + +K+ K +L R E E + GE+ L
Sbjct: 1886 NQLEGKVEEVD-LKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLN 1944
Query: 3029 ALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQ-----------EQGVEYQA 3077
L+ +F + L R T T D V + LE + E + Y
Sbjct: 1945 TLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMR 2004
Query: 3078 AMECLQK--------ADRRSLLSEIQALHAQMNGRKIT------------LKREQESEKP 3117
A + L + R L ++ AL Q + + +REQE +K
Sbjct: 2005 AHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKE 2064
Query: 3118 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA-------- 3169
+ +L NI+ K Q+ + +L +K++ +L+E K AE++ +L
Sbjct: 2065 NLKLSSENIELK-FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS 2123
Query: 3170 -QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEK 3228
+T ELE T+ K +++++ ++K + L ++ +A+ ++++ +L+ LEK K
Sbjct: 2124 GKTIPELEKTIGLMKKVVEKVQRENEQLKKASGI--LTSEKMANIEQENEKLKAELEKLK 2181
Query: 3229 AKLGR-------SEERDKEEL--EDLKFSLESQKQRNLQLNLLLEQQK-QLLNESQQKIE 3278
A LG S+ + E++ E+ + E +K+ + L + + ++LNE + ++
Sbjct: 2182 AHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNE-KMTVQ 2240
Query: 3279 SQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPP 3338
+ Q +E +G LE + + + M T +E E ++ T +
Sbjct: 2241 LEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLV 2300
Query: 3339 LPSEDLLKELQKQLEEKHSRIVELLN-----ETEKYKLDSLQT----RQQMEKDRQ--VH 3387
+ + +++ K E+ +I L + ETE+ LQ Q++K++ +H
Sbjct: 2301 KEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIH 2360
Query: 3388 RKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE 3447
+ +Q +L+ K++DL+ QL+ DLE Q L+ +++ K+E
Sbjct: 2361 QIEANKDQSGAESTIPDADQLKEKIKDLETQLKMS-------DLEKQHLKEEIKKL-KKE 2412
Query: 3448 LEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE 3487
LE + I E ++ + +N +L++K++
Sbjct: 2413 LENFDPSFFEEI------EDLKYNYKEEVKKNILLEEKVK 2446
Score = 165 bits (417), Expect = 9e-40
Identities = 425/2116 (20%), Positives = 856/2116 (40%), Gaps = 383/2116 (18%)
Query: 1838 ENEEL---MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR--ESFRQKQEATES 1892
+NE+L +++ ++ + E LL E S EL++ + + EA E
Sbjct: 172 KNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEK 231
Query: 1893 LKCQ-EELRERLHEESRAREQLAVELSK-------AEGVIDGYADEKTLFERQIQEKTDI 1944
++ Q +E+R+ L E + E++ E ++ + VID E ++ Q+QE TD+
Sbjct: 232 IEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL 291
Query: 1945 ID---------------RLEQELLCASNRLQELEAEQQQIQEERELLSR-QKEAMKAEAG 1988
+ ++E+ L S++ E+ QQ + RE L Q +A K+
Sbjct: 292 LKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVM 351
Query: 1989 PVEQ----------QLLQETEKLMKEKLEVQCQAEKVRDDLQ--KQVKALEIDVEEQVSR 2036
++Q L ++ E+ KE + C E ++++LQ K L ++
Sbjct: 352 ALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411
Query: 2037 FIELEQEKNTEL--------MDLRQQNQALEKQLEKMRKF------LDEQAID------- 2075
+++ +EK E D R++++ L + L++++ + L++ ++
Sbjct: 412 TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQ 471
Query: 2076 ---REHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132
R+ E ++ +EI KLE ++ F +E V + + T+ + L +
Sbjct: 472 IKIRDREIEILTKEINKLELKIS---DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528
Query: 2133 EQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA--KPELSLEVQ 2190
+Q + + Q +EIE LE E+ L + Q ++R A +L+L
Sbjct: 529 QQYRAENQILLKEIESLE------EERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTEN 582
Query: 2191 LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT-------R 2243
+ ++ D I ++ ++ +L+ E ++KNE + + ++ E + S T +
Sbjct: 583 I-SQGDRISERKLDLLSLKNM-----SEAQSKNEFLSRELIEKERDLERSRTVIAKFQNK 636
Query: 2244 LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE------------ 2291
L+EL +ENK ++ M+++ AIKE +D V G+ + II E
Sbjct: 637 LKELVEENKQLEEGMKEILQAIKEMQ----KDPDVKGGETSLIIPSLERLVNAIESKNAE 692
Query: 2292 ----------VEIDQLNEQVTKLQQQLKITTDNKV-----IEEKNELIRDLETQIECLMS 2336
++DQL + +L+Q+L+ + + + + N I LE + L
Sbjct: 693 GIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQ 752
Query: 2337 DQ------------ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE---EA 2381
+ + + + I NE + L QEL N +K SL + +
Sbjct: 753 SEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKF 812
Query: 2382 DSLKHQLDVV----IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER 2437
++HQ ++ ++EK + + +T EE +++ +++ K+ + L +L+ +
Sbjct: 813 AVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDS 872
Query: 2438 ESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINL 2497
+ ++KI + ENS + + ++ E ++ L LE Q + E K ++++
Sbjct: 873 DEMKKI--LAENSRKITVLQVN----EKSLIRQYTTLVELERQ--LRKENEKQKNELLSM 924
Query: 2498 ETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA--- 2554
E A+ E C ++ K EM KI LQK+V+ V+ +
Sbjct: 925 E-----------AEVCEKIGCLQRFK----------EMAIFKIAALQKVVDNSVSLSELE 963
Query: 2555 LVSQIQLEAVQEYAKFCQ-DNQTI--SSEPERTNIQNLNQLREDE-LGSDISALTLRISE 2610
L ++ E +Y Q DN + +S E +N++ + E + ++ ++
Sbjct: 964 LANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHT 1023
Query: 2611 LESQVVEMHTSL----ILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSP 2666
+E Q E T L ++K + I +++ KK+ L+ + E NE+++ E +K
Sbjct: 1024 IE-QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLE-MKELNERQRAEHCQKM-- 1079
Query: 2667 QDVEVLKTTTELFHSNE---ESGFFN----ELEALRAESVATKAELASYKEKA--EKLQE 2717
E L+T+ + E+ F L+A + E + + ELA KA + ++
Sbjct: 1080 --YEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQML-RDELADSVSKAVSDADRQ 1136
Query: 2718 ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKS 2777
+L E N L+ ++S++R+ A+ ++ IL + ++ +E E L ++L
Sbjct: 1137 RILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKE------VESLRMQLLDY 1190
Query: 2778 IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIIS-QFTEKI-EKMQELH 2835
A + +L + + A L+S S + E + + +K+ EK Q L+
Sbjct: 1191 QAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALY 1250
Query: 2836 AAEILDME-SRHISET-ETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSD 2893
A + ++H+ +T ++L+R+ A+ L ++E + K +IQ L++ + + E+ +S
Sbjct: 1251 YARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFS-KTMIQ-LQNDKLKIMQEMKNSQ 1308
Query: 2894 AYQTR----------------EICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATD 2937
E+ S+ + Q + H + ++ + E D
Sbjct: 1309 QEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKD 1368
Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDL 2997
++IK L + + SL E + H +Q++ W +
Sbjct: 1369 K--EEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMA--WDQR-------------- 1410
Query: 2998 ITKMQLQREAEVYDSSQSH-----ESFSDWRG-----------ELLLALQQVFLEERSVL 3041
++ L+R+ +++D Q+ + F + G +L +AL+++ R +L
Sbjct: 1411 --EVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIIL 1468
Query: 3042 LAAFRTELTALGTTDAVGLLNCLEQRIQEQG-VEYQAAMECLQKADRRSLLSEI------ 3094
+ + L EQ I + V + + A+R L++E+
Sbjct: 1469 ETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEME 1528
Query: 3095 -------QALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS-------------QML 3134
+ H + + L +++E K Q LLE ++++ L
Sbjct: 1529 PKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRL 1588
Query: 3135 EMQVE--LSSMKDRATELQEQ-------------LSSEKMVVAE-------LKSELAQTK 3172
E+Q + L+ K A +L +Q L+ + VAE L +L +
Sbjct: 1589 ELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVS 1648
Query: 3173 LELETTLKAQHKHLKELEAFRL--------EVKDKTDEVHLLNDTLASEQKKSRELQWAL 3224
+LE + +KE E +L EVK EV L L QK+S+ L+ L
Sbjct: 1649 QDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSEL 1708
Query: 3225 EKEKAKLGRSEERDKEEL-EDLKFSLE-SQKQRNLQLNLLLEQQKQLLNESQQKIESQRM 3282
+ +K R+ L E LK L +KQ+ LLE + ++ ++++I S
Sbjct: 1709 QAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATS 1768
Query: 3283 LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE 3342
+A L+ +Q + + L K ++ +++ L + +E L++S S
Sbjct: 1769 QKEAHLNVQQIVDRHTREL----KTQVEDLNENLLKLKE---ALKTSKNRENS-----LT 1816
Query: 3343 DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG- 3401
D L +L +L++K ++L E E+ ++ E RQ+ R T + + T+
Sbjct: 1817 DNLNDLNNELQKKQKAYNKILREKEEI------DQENDELKRQIKRLTSGLQGKPLTDNK 1870
Query: 3402 QKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI-- 3459
Q + ELQ KV+ L+ QLE K ++V DL+ + + +E + E E K+ +I
Sbjct: 1871 QSLIEELQRKVKKLENQLEGKVEEV---DLKPMKEKNAKEELIRWE---EGKKWQAKIEG 1924
Query: 3460 LYQNLNEPTTWSLTSDRTRNWVL-------QQKIEGETKESNYAKLIEMNGGGTGCNHEL 3512
+ L E T + N + ++K+ + K ++ G E
Sbjct: 1925 IRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEK 1984
Query: 3513 EMIRQKLQCVASKLQVLPQKASERLQFETADDEDFI---WVQENIDEIILQLQKLTGQQG 3569
E+ K + + + +L +A + L ++ ++ + ++QE + + Q K T
Sbjct: 1985 ELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDT---Y 2041
Query: 3570 EEPSL--VSPSTSCGSLTE------RLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3621
+PS+ + C E +L +N EL + Q ++ L+N V L+E
Sbjct: 2042 SKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCE 2101
Query: 3622 WYRQ------------TGAGRDNSSRFSLNGGAN-----IEAIIASEKEVWNREKLTLQK 3664
+ ++ G+GR + L +E + +++ + +
Sbjct: 2102 FLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSE 2161
Query: 3665 SLKRAEAEVYKLKAEL 3680
+ E E KLKAEL
Sbjct: 2162 KMANIEQENEKLKAEL 2177
Score = 75.1 bits (183), Expect = 1e-12
Identities = 147/697 (21%), Positives = 293/697 (42%), Gaps = 91/697 (13%)
Query: 3064 LEQRIQEQGV---EYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT--LKREQESEKPS 3118
LE+ +QE EY + + D + + H Q+ +++T LK + E + P
Sbjct: 243 LEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPI 302
Query: 3119 QELLEYNIQQ-------KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3171
+ +++ K +++E Q L +++++ Q L ++K V L+ + +
Sbjct: 303 MVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQ--LDADKSNVMALQQGIQER 360
Query: 3172 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALE--KEKA 3229
+++ + ++ KE+E ++D +E+ Q+ ++Q L+ KEK
Sbjct: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420
Query: 3230 KLGR---------SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQ 3280
K + E+DKE +E LK L+ + L + + K N Q KI +
Sbjct: 421 KEAERTAELAEADAREKDKELVEALK-RLKDYESGVYGLEDAVVEIKNCKN--QIKIRDR 477
Query: 3281 RMLYDAQLSEEQGRNLELQV---LLESEKVRIR---EMSSTLDRERELHAQLQSSDGTGQ 3334
+ ++ ++ LEL++ L E+E +R R E + +D + ++S Q
Sbjct: 478 EI----EILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL-----TEFRNSKHLKQ 528
Query: 3335 SRPPLPSEDLLKELQKQLEEK---HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3391
+ ++ LLKE++ EE+ +I ++ E K S T + + + +
Sbjct: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588
Query: 3392 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451
+E++ + K M E QSK E L R+L EK + + + + Q ++E ++ + E
Sbjct: 589 ISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLE 648
Query: 3452 E-KRESRRILYQNLNEP------TTWSLTS-DRTRNWVLQQKIEGETKESNYAKLIEMNG 3503
E +E + + + +P T+ + S +R N + + EG S + K
Sbjct: 649 EGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLK--AQVD 706
Query: 3504 GGTGCNHELEMIRQKL-QCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQ 3562
TG N EL RQ+L + + Q A L+ + + E + Q ++ +
Sbjct: 707 QLTGRNEEL---RQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGI 763
Query: 3563 KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRW 3622
L P ++PS++ + QN L + +L ++ L+N+ LE+ +
Sbjct: 764 DL-------PDGIAPSSA-----SIINSQNEYLIHLLQELENKEKKLKNLEDSLED---Y 808
Query: 3623 YRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
R+ R S + SEKE W E T+++ ++ E +V + +++
Sbjct: 809 NRKFAVIRHQQSL--------LYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKE 860
Query: 3683 -DSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQ 3718
++LL L DS+ + K + AE+ RK + Q
Sbjct: 861 YNNLLNALQMDSDEM-------KKILAENSRKITVLQ 890
Score = 50.1 bits (118), Expect = 4e-05
Identities = 76/388 (19%), Positives = 173/388 (44%), Gaps = 50/388 (12%)
Query: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDE-TMREF 228
E E+ R+L +R + G G + + E E I ++ ++ +Q ++ T +
Sbjct: 2106 EKAEVQRKLGHVRGS-GRSG-KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKM 2163
Query: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
+ ++++KL+ + ++L+A + S H + + ++I+ ++L ++ D
Sbjct: 2164 ANIEQENEKLKAELEKLKAHLGHQLSMHYESKT---KGTEKIIAENERLRKELKKETDAA 2220
Query: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----------------ETIIE 332
+K + L EK+ V E K+++ + Q + ET ++
Sbjct: 2221 EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLK 2280
Query: 333 ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
EL T I ++ + +LK + A + +EQ V K E ++++ + ++ +
Sbjct: 2281 ELETDIAKKNQSITDLKQLVKEATE-----REQKVNKYNEDLEQQIKILKHVPEGAETEQ 2335
Query: 393 EIKQLMGTVEELQKRNHKDSQFETDIVQRME--------QETQRKLEQLRAELDEMYGQQ 444
+K+ ++ L+ NH+ + + +++ ++E + T +QL+ ++ ++ Q
Sbjct: 2336 GLKR---ELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL 2392
Query: 445 IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504
+ +L +QH+ EE+K + K E+EN S+ + +K + NI L++
Sbjct: 2393 KMS---DLEKQHLK--EEIK-KLKKELENFDPSFFE---EIEDLKYNYKEEVKKNILLEE 2443
Query: 505 TNSQKEKLKEELGLILEEKCALQRQLED 532
+ +KL E+LG+ L A + ED
Sbjct: 2444 ---KVKKLSEQLGVELTSPVAASEEFED 2468
Score = 37.0 bits (84), Expect = 0.38
Identities = 40/158 (25%), Positives = 66/158 (41%), Gaps = 17/158 (10%)
Query: 3543 DDEDFIWVQENIDEIILQLQKLTGQQ--GEEPSLVSPSTSCGSLTERLLRQNAELT-GHI 3599
D +D +E D +++ L K+ + E+ V ++ Q EL +
Sbjct: 14 DPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEV 73
Query: 3600 SQLTEEK----NDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIAS----- 3650
+ EE+ N L+ VMKLE ++ +Q+ GRD +RF N +E +
Sbjct: 74 EKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRD--TRFLRNEICQLEKQLEQKDREL 131
Query: 3651 ---EKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSL 3685
EKE+ +K+ Q +L+ EAE K N L
Sbjct: 132 EDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRL 169
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 239 bits (610), Expect = 4e-62
Identities = 514/2583 (19%), Positives = 1073/2583 (41%), Gaps = 408/2583 (15%)
Query: 294 FTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLT 353
F +++ V E+ D+ + ++EI + + +EE++ + + + +L L
Sbjct: 322 FASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLE 381
Query: 354 TADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQ 413
D LL ++Q + ++ + LT ++ + + + +G + +++ N+ D
Sbjct: 382 EKD-LLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYAD-- 438
Query: 414 FETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM------KTRH 467
+ +I + +T + L E+DE V + ++ + + E+ K +
Sbjct: 439 -QFNIPTNITTKTHKLSINLLREIDES-----VCSESDVFSNTLDTLSEIEWNPATKLLN 492
Query: 468 KGEMENALRS----YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEK 523
+ +E+ L S Y N+ ++ +Q++ E+ +KL++ N E LE K
Sbjct: 493 QENIESELNSLRADYDNLVLDYEQLRTEK---EEMELKLKEKNDLDEFEA------LERK 543
Query: 524 CALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRK 583
++++ L+ E+S + ++ A + E++L+ + L ED ++ +S+K
Sbjct: 544 TKKDQEMQ-LIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQK 602
Query: 584 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED 643
+K + + LE +E K + L T L + E E+
Sbjct: 603 LENIKMDLSYS-----LESIEDPKQ---------MKQTLFDAETVALDAKRESAFLRSEN 648
Query: 644 LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ----KIETMQFEKD-----NLITKQNQ 694
LE++ EK+K+ L YKQ + +Q SQ K + EK+ N ITK
Sbjct: 649 LELK-----EKMKE-LATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTS 702
Query: 695 LILEISKLKDLQQSL-VNSKSEEMTLQINELQKEIEILRQEE---KEKGTLEQEVQ---- 746
LI + KDL +L + K ++ ++N+ +E E LR+E E +L EV+
Sbjct: 703 LI-DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRK 761
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
E+Q K+E L EK+ E + +L++ KT +D+ + ++
Sbjct: 762 EIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF-- 819
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866
+ K+ D +E++ ++++EENE + Q+ + L++E +K ++ + QELQE
Sbjct: 820 QNFKTLHMD--FEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQE 877
Query: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
K ++ E ++++ L E+L + TV+ + ++ E E
Sbjct: 878 ---------------KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLE 922
Query: 927 TLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE 986
++ + D +L E L++ E Q SD+ + + L ++SLKQ
Sbjct: 923 EVKTLTQEKDDLKQLQESLQI------ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQH 976
Query: 987 KEQVSLRCREL--EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVS-----KVN 1039
+E ++ ++ E+ N + EN + + G+ A+ + + K N
Sbjct: 977 QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN 1036
Query: 1040 KSFGEESKI--MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQK 1097
+ ++ KI ++++K + M +++EQL D ++ + D+L+K
Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096
Query: 1098 ELNVLKSEQND-LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEE 1156
+ ++ E+N ++ + E R C L +V E ++ EK + L +++L+ QEE
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLA------EVEEKLK-EKSQQLQEKQQQLLNVQEE 1149
Query: 1157 KIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTP 1216
+ +KI+++E +K + E H+ +L+ A +Y + + S+ E
Sbjct: 1150 MSEMQKKINEIE--NLKNELKNKELTLEHMETERLELAQKLNENY--EEVKSITKERKVL 1205
Query: 1217 ALKCEVNAEDKENSGDYISENE------DPELQDYRYEVQDFQENMHTLLNKVTEEYNKL 1270
+ ++++ YI E E EL+ +++ QE + L V+E+ ++
Sbjct: 1206 KELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI 1265
Query: 1271 LVLQTRLSKIWGQQTDGMKLEFGEENLP--KEETEFLSIHSQMTNLEDIDVNHKSKLSSL 1328
+ Q Q + L +E LP KE +E +++ L + S +
Sbjct: 1266 INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLAR 1325
Query: 1329 QDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDS 1388
++E+ +L E+ QE + I SL ++ + T+ +L V
Sbjct: 1326 IEMERLRLNEKFQESQEEIKSLTKERDNLK--------------------TIKEALEVKH 1365
Query: 1389 VVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVI 1448
+K++I T+ E K+E ++ ++ + E K++
Sbjct: 1366 ---------------DQLKEHIRETLAKIQESQSKQEQSL-------NMKEKDNETTKIV 1403
Query: 1449 VSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK-LSQDQIGFQTFETVD 1507
M + + L RI E SK+ QE H +EMK +++++ Q
Sbjct: 1404 SEMEQFKPKDSALLRIE--IEMLGLSKRL-----QESH--DEMKSVAKEKDDLQ------ 1448
Query: 1508 VKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVR----- 1562
+ +E + S +L E+ KEI+ + + + + C L EE ++ + +
Sbjct: 1449 -RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507
Query: 1563 -------QSIHDEISVSSMDA-SRQLMLNEEQLEDMRQEL--VRQYQEHQQATELLRQAH 1612
++I+D++ + ++ N +Q+ ++++++ ++Q++EH++A + Q+
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI 1567
Query: 1613 MRQM----ERQREDQEQLQ------EEIKRLNRQLAQRSSIDNEN---LVSERERVLLEE 1659
+M R +E QE++Q EE+KR+ L EN +V++ + +E
Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE 1627
Query: 1660 LEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSN 1719
+ LK ++ ++ CE+ + Q + N +E + + ++ + +
Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE-------- 1679
Query: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779
E ++ K + L +VEET+ ++R ++ I R +
Sbjct: 1680 EMRSVTKERDDL-----------RSVEETLK------VERDQLKENLRETITRDLEKQEE 1722
Query: 1780 KSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPEN 1839
VH H + E+I G + S+ T E + + + L S A D +
Sbjct: 1723 LKIVHM-HLKEHQETIDKLRG---------IVSEKTNEISNMQKDLEHSNDALKAQDLKI 1772
Query: 1840 EELMLNISSRL---QAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
+E + L Q ++KL +SE + +L + QK + K Q
Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNM-------------QKDLENSNAKLQ 1819
Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
E++ +E +A E + L K E ++QI++++ + +LE E L +
Sbjct: 1820 EKI-----QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874
Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
+L E E + + +ER+ L R +E +K E +++ LQET+ LE+Q +
Sbjct: 1875 QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES-LQETK---ARDLEIQQEL---- 1926
Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR 2076
K + L + +E V + E EK ++ D+++ L+K ++++K +
Sbjct: 1927 ----KTARMLSKEHKETVDKLREKISEKTIQISDIQKD---LDKSKDELQKKI------- 1972
Query: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQ 2136
QE+QK E QL V +S + E+EQL + + + + QL
Sbjct: 1973 --------QELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024
Query: 2137 RDIQERNEEIE---KLEFRVRELEQALLVSADTF------QKVEDRKHFGAVEAKPELSL 2187
+ + E EEI K +R ++++L + D F DR++ + KPE L
Sbjct: 2025 KKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNH---QVKPEKRL 2081
Query: 2188 EVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
++ + ++ + ++E L+++ E+++ E + +L + LE +E+
Sbjct: 2082 --LSDGQQHLTESLREKCSRIKELLKRY-SEMDDHYECLNRLSLDLE----------KEI 2128
Query: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ 2307
E + +L L L Q +H+ K Q +E ++ + KL+
Sbjct: 2129 EFQKELSMRVKANLSLPY-------LQTKHI--EKLFTANQRCSMEFHRI---MKKLKYV 2176
Query: 2308 LKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE--EEIEQLNEVIEKLQQELAN 2365
L T K+ EE++E I E M + V++ +E +I+ L + + +EL +
Sbjct: 2177 LSYVT--KIKEEQHESINKFE------MDFIDEVEKQKELLIKIQHLQQDCDVPSRELRD 2228
Query: 2366 IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ 2425
+ +M+ H D + + + E QQV + +EMT T F + +
Sbjct: 2229 LKLNQNMDLHIEEILKDFSESEFPSIKTE----FQQVLSNRKEMTQFLEEWLNTRFDIEK 2284
Query: 2426 LTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT---EDALKSL--ENQ 2480
L +++E + + ++ + N + +AI + S + E ++ E LKSL +N+
Sbjct: 2285 LKN---GIQKENDRICQVNNFFNNRI-IAIMNESTEFEERSATISKEWEQDLKSLKEKNE 2340
Query: 2481 TYFKSFE----ENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEML 2536
FK+++ G+ +N T+ + S T+ +++++ + +
Sbjct: 2341 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK 2400
Query: 2537 QKKIVNLQKIVE--EKVAAALVSQIQ-----LEAVQEYAKFCQDNQTISSEPERTNIQNL 2589
+ KI+ +QK +E + A L +++ LE +E + QD + ++P + I++
Sbjct: 2401 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIED- 2459
Query: 2590 NQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKL 2649
L++ ++ + +M + EKE A K +E +K+++ +L
Sbjct: 2460 ----------------LKMKLVKIDLEKMKNAKEFEKE--ISATKATVEYQKEVI---RL 2498
Query: 2650 LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE------SGFFNELEA--LRAESVAT 2701
L N ++ ++ QD V+ T+ SN+ SG +A L++E +
Sbjct: 2499 LRENLRRSQQ------AQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRL 2552
Query: 2702 KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2761
+ E++ K+ Q E L+K+ N L + + + + KE+ E + + S
Sbjct: 2553 EKEISKLKQ-----QNEQLIKQKN--ELLSNNQHLSNEVKTWKERTLKREAHKQVTCENS 2605
Query: 2762 KKA 2764
K+
Sbjct: 2606 PKS 2608
Score = 234 bits (596), Expect = 2e-60
Identities = 465/2359 (19%), Positives = 992/2359 (42%), Gaps = 302/2359 (12%)
Query: 155 THLEMMESELAGKQHEIEEL-----NRELEEM-RVTYGTEGLQQLQEFEAAIKQRDGIIT 208
T + ME + + E ++L N ++E + R+ + L QE +A K+R
Sbjct: 366 TRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR----- 420
Query: 209 QLTANLQQARREKDETMREFLEL----TEQSQKLQIQF-QQLQASETLRNSTHSSTAADL 263
+T L + + K+ + + T ++ KL I +++ S + S+T L
Sbjct: 421 -VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTL 479
Query: 264 LQAKQQILT---HQQQLEEQ--------DHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQ 312
+ + T +Q+ +E + D+L+ DY++ + + L+EK + E E
Sbjct: 480 SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEA 539
Query: 313 DKKVENSNKEEIQEKETIIEELNTK--IIEEEKKTLELKDKLTTADKLLGELQEQIVQ-- 368
+E K++ QE + I E N K + E +L+++L++ +LL E ++QI +
Sbjct: 540 ---LERKTKKD-QEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQ 595
Query: 369 ---KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425
+Q+++N+K++L+ S +S E+ KQ+ T+ + + D++ E+ ++ E
Sbjct: 596 EYIDSQKLENIKMDLSYS----LESIEDPKQMKQTLFDAE-TVALDAKRESAFLRSENLE 650
Query: 426 TQRKLEQLRAELDEMYGQ-QIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT-- 482
+ K+++L +M Q+ Q + E ++ +E+ E+++A + +T
Sbjct: 651 LKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK-------ELQSAFNEITKLTSL 703
Query: 483 ----VNEDQIKLMNV--AINELNIKLQDTNSQKEKLKEELGLILEEKC------ALQRQL 530
V +D + + + I +L +L + E L+EE+ L+ E K L++++
Sbjct: 704 IDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEI 763
Query: 531 EDLVEELSFSREQIQRARQTIAEQESK----LNEAHKSLSTVEDLKAEIVSASESRKELE 586
+D EEL + + + +ES+ L E K+ + ++ S + + +
Sbjct: 764 QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFK 823
Query: 587 LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ--EAELERLRTQLLFSHEEELSKLKEDL 644
H YK+ LE E+ +++ E+Q ++ L L+T+L + +E K +
Sbjct: 824 TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTR--- 880
Query: 645 EIEHRIN-IEKLKDNLG---------IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694
E++ R+N +E+LK+ L K I + ++++T+ EKD+L Q
Sbjct: 881 EVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQES 940
Query: 695 LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL 754
L +E +LK VN + +L+ +E L+Q ++ TL+ ++ E +
Sbjct: 941 LQIERDQLKSDIHDTVNMNIDTQ----EQLRNALESLKQHQETINTLKSKISEEVSRNLH 996
Query: 755 LEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL----DSIK 810
+E+ E +++ Q+K ++ + + +TL +K + + Q+ ++ L + ++
Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056
Query: 811 SKSKDSVWEKE---------IEILIEENEDL-----------------KQQCIQLNEEIE 844
+ + EKE IE+ IE E+L K I+ E+
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Query: 845 KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK-QELE-YKSKLKALNEELHL 902
+ + + E+ + Q+LQE+ LL V++++ + + K E+E K++LK N+EL L
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK--NKELTL 1174
Query: 903 QRINPTTVKMKSSV---FDEDKTFVAETLEMGEV-----------------VEKDTTELM 942
+ + +++ + ++E K+ E + E+ +E +
Sbjct: 1175 EHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTK 1234
Query: 943 EKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIIN 1002
E+L++ E + + +L + +K +I + KS + +E++ + E E++ N
Sbjct: 1235 EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN 1294
Query: 1003 HNRAENVQSCDTQVSSLLDGVVT---MTSRGAEGSVSKVNKSF---GEESKIMVEDKVSF 1056
Q ++ L + T T E ++N+ F EE K + +++ +
Sbjct: 1295 VKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354
Query: 1057 ENMTVGEESKQEQL---ILDHLPSVTKESSLR------ATQPSENDKLQKELNVLKSEQN 1107
+ + E K +QL I + L + + S + + +E K+ E+ K + +
Sbjct: 1355 KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDS 1414
Query: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL 1167
L L++E + + LS D+++ + + D +E++ ++ +++KE +
Sbjct: 1415 AL-LRIEIEMLGLSKRLQESHDEMKSVAKEKDD---LQRLQEVLQSESDQLKE-----NI 1465
Query: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
+ K ET +E K H + + ++ ++E L E T + E +
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINE----LRVNLSEKETEISTIQKQLEAINDKL 1521
Query: 1228 ENSGDYISENED-------PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKI 1280
+N I E E+ E+Q+ E++ F+E+ + + +K+L L RL
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQ-- 1579
Query: 1281 WGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLE--E 1338
+ + +++ E+ K E L I ++ K K S ++ + K+
Sbjct: 1580 --ESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVN 1637
Query: 1339 QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQR 1398
+ QE I L++Q + + N E I RL + + V +
Sbjct: 1638 ETQEKMCEIEHLKEQFETQKLNLE-NIETENIRLTQILHENLEEMRSVTKERDDLRSVEE 1696
Query: 1399 TM-YPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQ 1457
T+ +K+N+ TI + + +EE IV + K++QE +++ I +
Sbjct: 1697 TLKVERDQLKENLRETI--TRDLEKQEELKIVHMHLKEHQETIDK-------LRGIVSEK 1747
Query: 1458 QTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPL 1517
E+S + E++ + +A + QE+ M L + Q ET+D K +
Sbjct: 1748 TNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ------ETID-KLRGIVSEK 1800
Query: 1518 SKELGEHGKEILLSNS----DPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSS 1573
+ +L K++ SN+ ++ ++ ++T+ +++ K + + +I S
Sbjct: 1801 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS 1860
Query: 1574 MDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL 1633
+ S+ + N + + + L ++ L R ++ER +QL+E ++
Sbjct: 1861 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER-----DQLKESLQET 1915
Query: 1634 N-RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCE-LRNSSTQ---TQNG 1688
R L + + ++S+ + +++L REK+ + ++ S Q ++
Sbjct: 1916 KARDLEIQQELKTARMLSKEHKETVDKL----------REKISEKTIQISDIQKDLDKSK 1965
Query: 1689 NENQGEVEEQTFKEKELDRKPEDVPPEILS-NERYALQK----ANNRLLKILLEVVKTTA 1743
+E Q +++E KE +L R EDV NE L+K N + + ++ + T
Sbjct: 1966 DELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTK 2025
Query: 1744 AVEETIGRHVLGILDRSSKSQSSASL-IWRSEAEASVKSCV--HEEHTRVTDESIPSYSG 1800
+ E++ + +R + SL + R + A+++ + ++ +V E G
Sbjct: 2026 KLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2085
Query: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860
++ + E+ + + + L R +E+D E L +RL +EK +E
Sbjct: 2086 QQ------HLTESLREKCSRIKELLKRY----SEMDDHYECL-----NRLSLDLEKEIEF 2130
Query: 1861 ISETSSQLE---HAKVTQTELMRESFRQKQEAT-ESLKCQEELRERLHEESRAREQLAVE 1916
E S +++ QT+ + + F Q + E + ++L+ L ++ +E+
Sbjct: 2131 QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHES 2190
Query: 1917 LSKAE-GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
++K E ID +K L + I L+Q+ S L++L+ Q E+
Sbjct: 2191 INKFEMDFIDEVEKQKELLIK--------IQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242
Query: 1976 LSRQKEAMKAEAGPVEQQLL---QETEKLMKEKLEVQCQAEKVRDDLQKQ---------- 2022
L E+ QQ+L +E + ++E L + EK+++ +QK+
Sbjct: 2243 LKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNF 2302
Query: 2023 ----VKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH 2078
+ A+ + E R + +E +L L+++N+ L K + ++ L A
Sbjct: 2303 FNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPT 2362
Query: 2079 ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD 2138
+D + QL T ++ +L N L E + ++Q++
Sbjct: 2363 TQDNKNPHVTSRATQL------------TTEKIRELENSLHEAKESAMHKESKIIKMQKE 2410
Query: 2139 IQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAI 2198
++ N+ I KL+ +V E + L + +T Q ++D+ GA K E+ L+ + I
Sbjct: 2411 LEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIE---DLKMKLVKI 2467
Query: 2199 D-RKEKEITNLEEQLEQFREELENKNEEVQQLHMQL-EIQKKESTTRLQELEQENKLFKD 2256
D K K E+++ + +E + E ++ L L Q+ + T+ + E K
Sbjct: 2468 DLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKP 2527
Query: 2257 DMEKLGLAI-KESDAMSTQDQHVLFGK-FAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2314
G I + + A+ + +H+ K +++ Q+ E I Q NE ++ Q ++ +
Sbjct: 2528 LTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQH---LSNEV 2584
Query: 2315 KVIEEKNELIRDLETQIEC 2333
K +E+ L R+ Q+ C
Sbjct: 2585 KTWKERT-LKREAHKQVTC 2602
Score = 216 bits (551), Expect = 3e-55
Identities = 478/2347 (20%), Positives = 983/2347 (41%), Gaps = 365/2347 (15%)
Query: 276 QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK--ETIIEE 333
++ + LL+ Y+K+ D Q+ + + + ME+D+ + ++++ +K IE
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 334 LNTKIIEEEKKTLELKDKLTTADKL---LGELQEQ---------IVQKNQEIKNMKLELT 381
L ++ TL+ + K ++ LG++ + + N K KL +
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSIN 456
Query: 382 NSKQKERQSSEEIKQLMGTVEELQK---------RNHKDSQFETDIVQRMEQETQRKLEQ 432
++ + E T++ L + N ++ + E + ++ EQ
Sbjct: 457 LLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQ 516
Query: 433 LRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMN 492
LR E +EM +++K++ +E KT+ EM+ + SN+ ++ N
Sbjct: 517 LRTEKEEME----LKLKEKNDLDEFEALER-KTKKDQEMQ-LIHEISNLKNLVKHAEVYN 570
Query: 493 VAI-NELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQ---RAR 548
+ NEL+ K++ +++++K+ L+E Q+ LE++ +LS+S E I+ + +
Sbjct: 571 QDLENELSSKVELLREKEDQIKK-----LQEYIDSQK-LENIKMDLSYSLESIEDPKQMK 624
Query: 549 QTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN 608
QT+ + E+ +A + + L++E + E KEL ++ + ++ LE +K
Sbjct: 625 QTLFDAETVALDAKRESAF---LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK 681
Query: 609 AVLDRMAESQEA--ELERLRT--------QLLFSHEEE--LSKLKEDLEIEHRINIEKLK 656
+D E Q A E+ +L + LL + E E ++ L+++L E N E L+
Sbjct: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN-EALR 740
Query: 657 DNLGI-----HYKQQIDGLQNEMSQKIETMQF---EKDNLI-------TKQNQLILEISK 701
+ + + +++ L+ E+ K E + EKD L ++ L+ EI K
Sbjct: 741 EEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800
Query: 702 LK-DLQQSLVNSKSEEM------TLQINELQKEIEILRQEEK---EKGTLEQEVQELQ-- 749
K DL + N KS + TL ++ QK +L + E+ E L +E Q+
Sbjct: 801 TKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860
Query: 750 ---LKTELLEK--QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVS------ 798
LKTEL K +++EK ++QE+ ++E L++ TL+ + + T ++
Sbjct: 861 LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQT 920
Query: 799 -----------------QEERLIFLDSIKSKSKDSV-----WEKEIEILIEENEDLKQQC 836
QE I D +KS D+V ++++ +E + ++
Sbjct: 921 LEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI 980
Query: 837 IQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLE---------DSKNKQEL 887
L +I ++ + E+N E Q++ + K K DLE D K+ + +
Sbjct: 981 NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDK-KQDLEAKNTQTLTADVKDNEII 1039
Query: 888 EYKSKLKAL-NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
E + K+ +L E+ LQ++ + + K + + K + T+E E + EL ++ E
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099
Query: 947 VTKREKL-------ELSQ---RLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRE 996
+ +EK ELS+ RL+++ E+LK+K ++ +++ ++++E ++ + E
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159
Query: 997 LEIIINH--NRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV 1054
+E + N N+ ++ +T+ L ++ + +V KS +E K++ E +
Sbjct: 1160 IENLKNELKNKELTLEHMETERLEL--------AQKLNENYEEV-KSITKERKVLKELQK 1210
Query: 1055 SFEN------------MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVL 1102
SFE G ++K E+L + H+ + ++ + S ++K + +N
Sbjct: 1211 SFETERDHLRGYIREIEATGLQTK-EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269
Query: 1103 KSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQ 1162
E++ +LQ E + +V +V E E ++ E + ++ K+
Sbjct: 1270 DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQE--------TMNELELLTEQSTTKDST 1321
Query: 1163 KIHQLELQTM----KTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218
+ ++E++ + K QE+ +E K L L K + E L+ L E+ L
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTKERDNL-KTIKEA----LEVKHDQLKEHIRETL 1376
Query: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLS 1278
++ K+ + E +D E E++ F+ LL ++ + LS
Sbjct: 1377 AKIQESQSKQEQSLNMKE-KDNETTKIVSEMEQFKPKDSALL--------RIEIEMLGLS 1427
Query: 1279 KIWGQQTDGMKLEFGEENLPKEETEFLSIHSQM--TNLEDIDVNHKSKLSSLQDLEKTKL 1336
K + D MK E++ + E L S N+++I H L+ E+ K+
Sbjct: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH------LETEEELKV 1481
Query: 1337 EE-QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESD 1395
++E E I+ L+ L E E EI +QK+L+A+++ L I E +
Sbjct: 1482 AHCCLKEQEETINELRVNLSEK----ETEISTIQKQLEAIND-----KLQNKIQEIYEKE 1532
Query: 1396 AQRTMYPGSCVKKNIDGTIEFSGEFGVKE---ETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452
Q + S V++ ++ +F K+ ++ K+LE + Q +E ++++
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIK-- 1590
Query: 1453 IAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKE 1512
++ E+ R+ +++ +DQ+ T E V K KE
Sbjct: 1591 ----EKEEMKRVQ-----------------------EALQIERDQLKENTKEIV-AKMKE 1622
Query: 1513 EFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVS 1572
S+E KE + + K C + +E F K + + I
Sbjct: 1623 -----SQE-----KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL------ENIETE 1666
Query: 1573 SMDASRQLMLNEEQL-------EDMRQELVRQYQEHQQATELLRQAHMRQMERQRE---- 1621
++ ++ L N E++ +D+R E Q E LR+ R +E+Q E
Sbjct: 1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIV 1726
Query: 1622 --DQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
++ QE I +L +++++ N +S ++ L +ALK L +E+L
Sbjct: 1727 HMHLKEHQETIDKLRGIVSEKT-----NEISNMQKDLEHSNDALKAQDLKIQEELRIAHM 1781
Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN-NRLLKILLEV 1738
+ Q + ++ +G V E+T K + + E+ ++ E+ KAN ++L+ + +V
Sbjct: 1782 HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL--QEKIQELKANEHQLITLKKDV 1839
Query: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
+T V E + L + K QS + S+ E + + H E++
Sbjct: 1840 NETQKKVSE------MEQLKKQIKDQS----LTLSKLEIENLNLAQKLH-----ENLEEM 1884
Query: 1799 SGSDMPRNDINMWSKVTE-EGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL 1857
R+++ + + E +L + L + EI E + + +S + V+KL
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM-LSKEHKETVDKL 1943
Query: 1858 LEAISETSSQLEHAK----VTQTELMRESFRQKQEATESLKCQEEL---RERLHEESRAR 1910
E ISE + Q+ + ++ EL ++ +++ + L+ +E++ ++++E + +
Sbjct: 1944 REKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLK 2003
Query: 1911 EQL-AVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQE-LEAEQQQ 1968
+Q A LS +D + K L E E+ I+ + EL R++E L+ E+ Q
Sbjct: 2004 KQFEAQNLSMQSVRMDNFQLTKKLHES--LEEIRIVAKERDEL----RRIKESLKMERDQ 2057
Query: 1969 -IQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK-------VRDDLQ 2020
I RE+++R ++ + + E++LL + ++ + E L +C K DD
Sbjct: 2058 FIATLREMIARDRQNHQVKP---EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY 2114
Query: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER 2080
+ + L +D+E+++ EL L Q + +EK F Q E
Sbjct: 2115 ECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEK------LFTANQRCSME--- 2165
Query: 2081 DVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQ 2140
F + ++KL+ L V + I E Q + + ++ +K ELL+ + LQ+D
Sbjct: 2166 --FHRIMKKLKYVLSYVTK---IKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDC- 2219
Query: 2141 ERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDR 2200
++ E R +L Q + + + K F +++ + + Q+ + R + +
Sbjct: 2220 ----DVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQ-----QVLSNRKEMTQ 2270
Query: 2201 KEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEK 2260
+E N +E+ + ++ +N+ + Q++ + E E+ + + E+
Sbjct: 2271 FLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQ 2330
Query: 2261 LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEK 2320
++KE + ++ L A Q D N VT QL T K+ E +
Sbjct: 2331 DLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQL---TTEKIRELE 2387
Query: 2321 NELIRDLETQIECLMSDQECVKRNREEE------------IEQLNEVIEKLQQELANIGQ 2368
N L E + + + + +K +E E + + N+ +EK ++ + +
Sbjct: 2388 NSL---HEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQD 2444
Query: 2369 KTSMNAHSLSEEADSLKHQLDVVIAEKL----ALEQQVETANEEMTFMKNVLK--ETNFK 2422
K ++ A EE + LK +L + EK+ E+++ + + K V++ N +
Sbjct: 2445 KVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLR 2504
Query: 2423 MNQLTQE 2429
+Q Q+
Sbjct: 2505 RSQQAQD 2511
Score = 207 bits (527), Expect = 2e-52
Identities = 401/1996 (20%), Positives = 835/1996 (41%), Gaps = 281/1996 (14%)
Query: 1717 LSNERYALQKANNRLLKILLEVVKTTAAV------EETIGRHVLGILDRSSKSQSSASLI 1770
L E+ LQK N ++ L ++ T++++ + R V L + +K ++S +
Sbjct: 379 LLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNS-NYA 437
Query: 1771 WRSEAEASVKSCVHE---EHTRVTDESIPSYSGSDMPRNDINMWSKV---------TEEG 1818
+ ++ + H+ R DES+ S SD+ N ++ S++ +E
Sbjct: 438 DQFNIPTNITTKTHKLSINLLREIDESV--CSESDVFSNTLDTLSEIEWNPATKLLNQEN 495
Query: 1819 TELSQRLVRSGFAGTEID-----PENEELMLNISSR--------LQAAVEK-----LLEA 1860
E +R+ + +D E EE+ L + + L+ +K L+
Sbjct: 496 IESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHE 555
Query: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHE--ESRAREQLAVELS 1918
IS + ++HA+V +L E E L+ +E+ ++L E +S+ E + ++LS
Sbjct: 556 ISNLKNLVKHAEVYNQDLENEL----SSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS 611
Query: 1919 KA-EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLS 1977
+ E + D ++TLF+ E L A L +E +++E+ + L+
Sbjct: 612 YSLESIEDPKQMKQTLFDA------------ETVALDAKRESAFLRSENLELKEKMKELA 659
Query: 1978 RQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF 2037
+ M+ + + QL E +K M+ LE + Q+ +++ K ++ V + +
Sbjct: 660 TTYKQMENDIQLYQSQL--EAKKKMQVDLEKELQS--AFNEITKLTSLIDGKVPKDLLCN 715
Query: 2038 IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVV 2097
+ELE + + DL+++ L K++E E + ++E+ L + LK +
Sbjct: 716 LELEGK----ITDLQKE---LNKEVE---------------ENEALREEVILLSE-LKSL 752
Query: 2098 PRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE 2157
P EVE+L +++K+++ + K++L ++ + ++ L + + +
Sbjct: 753 PS----------EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK 802
Query: 2158 QALLVSADTFQKVEDR-KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFR 2216
L + ++ + ++F + E ++ L+ +R +EI NL ++ ++F
Sbjct: 803 DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN----ERMNQEIVNLSKEAQKFD 858
Query: 2217 EELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQ 2276
L E+ +L+ + +E RL E+EQ K+ +E ++S + + +
Sbjct: 859 SSLGALKTELSYKTQELQEKTREVQERLNEMEQ----LKEQLEN-----RDSTLQTVERE 909
Query: 2277 HVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMS 2336
L + Q E+ + Q + + +LQ+ L+I E+++L D+ + +
Sbjct: 910 KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQI--------ERDQLKSDIHDTVNMNID 961
Query: 2337 DQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH---SLSEEADSLKHQLDVVIA 2393
QE + RN E ++Q E I L+ + I ++ S N H + E D + ++ V I
Sbjct: 962 TQEQL-RNALESLKQHQETINTLKSK---ISEEVSRNLHMEENTGETKDEFQQKM-VGID 1016
Query: 2394 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNV 2453
+K LE + T N + E K+ L QE L++ ESV + + +
Sbjct: 1017 KKQDLEAK-NTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
Query: 2454 AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDL 2513
I+ +++ EL + L ++ K E K+ +G + RL ++E + K
Sbjct: 1076 NIEMTIENQEELRL-LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1134
Query: 2514 ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEE----KVAAALVSQIQLEAVQEYAK 2569
+L + +Q+ ++QE E +QKKI ++ + E ++ + +LE Q+ +
Sbjct: 1135 QLQEKQQQLLNVQE----EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNE 1190
Query: 2570 FCQDNQTISSEPE-RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQ 2628
++ ++I+ E + +Q + D L I + + + ++ H L +E
Sbjct: 1191 NYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQET 1250
Query: 2629 VEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFF 2688
++ ++V EK +++ Q L + + K Q E Q E+L E+ + E
Sbjct: 1251 IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQ--ELLPNVKEVSETQET---M 1305
Query: 2689 NELEALRAESVATKAE-LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL 2747
NELE L +S + LA + + +L E+ + + SL K+ RD+L KE L
Sbjct: 1306 NELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE----RDNLKTIKEAL 1361
Query: 2748 SILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQT--------PQILV 2799
+ + + ++E+ + S ++ + + T KI S + +I +
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI 1421
Query: 2800 KNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAE-------ILDMESRHISETET 2852
+ G+ LQ S + + +++ + ++++QE+ +E I ++ ++H+ E
Sbjct: 1422 EMLGLSKRLQE---SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478
Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
LK H LKE+ T+ + L KE Q + +D + Q
Sbjct: 1479 LKVAHCC----LKEQEETINELRVNLSEKE-------TEISTIQKQLEAINDKLQNKIQE 1527
Query: 2913 IYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHS 2972
IY Q F+I +E + F + K A+ + ++L LT E+
Sbjct: 1528 IYEKEEQ-FNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586
Query: 2973 IQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQ 3032
I + EE K + +D + + + A++ +S + F
Sbjct: 1587 IMIKEK---EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQF------------- 1630
Query: 3033 VFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS 3092
++TA+ T C + ++EQ + +E ++ + R
Sbjct: 1631 --------------LKMTAVNETQEK---MCEIEHLKEQFETQKLNLENIETENIRLT-- 1671
Query: 3093 EIQALHAQMNG-RKITLKRE-----QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDR 3146
Q LH + R +T +R+ +E+ K ++ L+ N+++ ++ LE Q EL +
Sbjct: 1672 --QILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH 1729
Query: 3147 ATELQEQLSSEKMVVAELKSELAQTKLELETT---LKAQH-KHLKELEAFRLEVKDKTDE 3202
E QE + + +V+E +E++ + +LE + LKAQ K +EL + +K++ +
Sbjct: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789
Query: 3203 VHLLNDTLASEQKKSRELQWALEKEKAKLGRSEER---DKEELEDLKFSLESQKQRNLQL 3259
+ L ++ + K +Q LE AKL + ++ +L LK + +++ ++
Sbjct: 1790 IDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849
Query: 3260 NLLLEQQK-QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3318
L +Q K Q L S+ +IE+ L+++ NLE + E+ +R + TL
Sbjct: 1850 EQLKKQIKDQSLTLSKLEIEN------LNLAQKLHENLEEMKSVMKERDNLRRVEETLKL 1903
Query: 3319 ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQ 3378
ER+ +L++ L+E +R +E+ E + ++ S + ++
Sbjct: 1904 ERD-------------------------QLKESLQETKARDLEIQQELKTARMLSKEHKE 1938
Query: 3379 QMEKDRQ-VHRKTLQTEQ------EANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431
++K R+ + KT+Q ++ E QKK+ ELQ K L R E+ K++
Sbjct: 1939 TVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKIN- 1997
Query: 3432 EGQRLQGIMQEFQKQELEREEKR----ESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE 3487
++ + ++F+ Q L + R + + L+++L E + D R K+E
Sbjct: 1998 ---EMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME 2054
Query: 3488 GETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDF 3547
+ + ++I + E ++ Q + L+ + E L+ + D+ +
Sbjct: 2055 RDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY 2114
Query: 3548 IWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSL----TERLLRQNAELTGHISQLT 3603
E ++ + L L+K Q E V + S L E+L N + ++
Sbjct: 2115 ----ECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIM 2170
Query: 3604 EEKNDLRNMVMKLEEQ 3619
++ + + V K++E+
Sbjct: 2171 KKLKYVLSYVTKIKEE 2186
Score = 197 bits (502), Expect = 1e-49
Identities = 498/2516 (19%), Positives = 1031/2516 (40%), Gaps = 394/2516 (15%)
Query: 1052 DKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRL 1111
++VS + + K+ + L V+ E+ +A + + +L +E ++L+ QN+
Sbjct: 336 NEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNE--- 392
Query: 1112 QMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQT 1171
+ + + LV S+ + +E K + L KI +++ + +
Sbjct: 393 --KIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLG---------KINKMKNSNYADQFN 441
Query: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSG 1231
+ T T K L+ ++ ++V E F TL ++ + PA K +N
Sbjct: 442 IPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKL-LN-------- 492
Query: 1232 DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLE 1291
QEN+ + LN + +Y+ L++ +L + + M+L+
Sbjct: 493 ---------------------QENIESELNSLRADYDNLVLDYEQLRT----EKEEMELK 527
Query: 1292 FGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQ 1351
E+N + EF ++ + +++ + H+ +S+L++L K E Q+LE+ +SS
Sbjct: 528 LKEKN---DLDEFEALERKTKKDQEMQLIHE--ISNLKNLVK-HAEVYNQDLENELSSKV 581
Query: 1352 QQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITES-----DAQRTMYPGSCV 1406
+ L+E E K+LQ +S ++ +D ES ++T++ V
Sbjct: 582 ELLREKEDQI--------KKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETV 633
Query: 1407 KKNIDGTIEF--SGEFGVKEETNIVKLLEKQ-------YQEQLEEEVAKVI---VSMSIA 1454
+ F S +KE+ + KQ YQ QLE + + + A
Sbjct: 634 ALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSA 693
Query: 1455 FAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF 1514
F + T+L+ + GK K + E + K ++ +V E
Sbjct: 694 FNEITKLTSLIDGKV----PKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSEL 749
Query: 1515 KPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSM 1574
K L E+ KEI + + H I KD + + E+ K+ Q + +EI +
Sbjct: 750 KSLPSEVERLRKEIQDKSEELHIITSEKDKLFS---EVVHKESRV---QGLLEEIGKTKD 803
Query: 1575 DASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLN 1634
D + N + + Q + + +Q +++ + + ER ++ L +E ++ +
Sbjct: 804 DLATT-QSNYKSTDQEFQNFKTLHMDFEQKYKMV----LEENERMNQEIVNLSKEAQKFD 858
Query: 1635 RQL-AQRSSIDNENL-VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQ 1692
L A ++ + + + E+ R + E L ++QL +E+L E R+S+ QT
Sbjct: 859 SSLGALKTELSYKTQELQEKTREVQERLNEMEQL----KEQL--ENRDSTLQTVE----- 907
Query: 1693 GEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRH 1752
E+T ++L + E+V + L+ E+ L++ L +E + + + +T+
Sbjct: 908 ---REKTLITEKLQQTLEEV--KTLTQEKDDLKQLQESLQ---IERDQLKSDIHDTVN-- 957
Query: 1753 VLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWS 1812
+ I + + SL E ++KS + EE +R +++M
Sbjct: 958 -MNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR-----------------NLHMEE 999
Query: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELML-----NISSRLQAAVEKLLEAISETSSQ 1867
E E Q++V +++ +N + + N Q + L++ +E
Sbjct: 1000 NTGETKDEFQQKMVGID-KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM 1058
Query: 1868 LEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS---KAEGVI 1924
LE + + E ++ ++ E T ++ QEELR E + +E +A E + K EG +
Sbjct: 1059 LESV-IAEKEQLKTDLKENIEMT--IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGEL 1115
Query: 1925 DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK---E 1981
D E +++EK+ + +Q+LL + E++ + +I+ + L ++ E
Sbjct: 1116 SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE 1175
Query: 1982 AMKAEAGPVEQQL---LQETEKLMKEKL---EVQCQAEKVRDDLQ---KQVKALEIDVEE 2032
M+ E + Q+L +E + + KE+ E+Q E RD L+ ++++A + +E
Sbjct: 1176 HMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE 1235
Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092
++ + + +++ E +D +++ + EK + ++ Q +++ H + Q+EI L +
Sbjct: 1236 EL-KIAHIHLKEHQETIDELRRSVS-----EKTAQIINTQDLEKSHTK--LQEEIPVLHE 1287
Query: 2093 QLKVVPRFQPISEHQT--REVEQLANHLKEK-TDKCSELLLSKEQLQRDIQERNEEIEKL 2149
+ +++P + +SE Q E+E L K + + + + + +L QE EEI+ L
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 2150 ---EFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206
++ +++AL V D ++H AK + S Q Q+ + K+ E T
Sbjct: 1348 TKERDNLKTIKEALEVKHDQL-----KEHIRETLAKIQESQSKQEQSLN--MKEKDNETT 1400
Query: 2207 NLEEQLEQFRE----------ELENKNEEVQQLHMQLE--IQKKESTTRLQE-LEQENKL 2253
+ ++EQF+ E+ ++ +Q+ H +++ ++K+ RLQE L+ E+
Sbjct: 1401 KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQ 1460
Query: 2254 FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD 2313
K++++++ E++ + H + + I E V + + +++ +Q+QL+ D
Sbjct: 1461 LKENIKEIVAKHLETEE-ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIND 1519
Query: 2314 ---NKVIE--EKNELIRDLE-TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2367
NK+ E EK E + ++++ +++ + K +R+ + L + K+ EL N
Sbjct: 1520 KLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKML-ELTNRL 1578
Query: 2368 QKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQV--------ETANEEMTFMK-NVLKE 2418
Q++ + +E + +K + + E+ L++ E+ +E F+K + E
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638
Query: 2419 TNFKMNQL--------TQELFSLKRERESVEKIQSIPEN-----SVNVAIDHLSKDKPEL 2465
T KM ++ TQ+L E E++ Q + EN SV D L + L
Sbjct: 1639 TQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETL 1698
Query: 2466 EVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQ-----LESTVSAKDLELTQCYK 2520
+V D LK +T + E+ + I+++ + Q L VS K E++ K
Sbjct: 1699 KV--ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQK 1756
Query: 2521 QIKDMQEQGQFETEMLQKKI-VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISS 2579
++ + + + +Q+++ + + E++ + I E + + +D + ++
Sbjct: 1757 DLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNA 1816
Query: 2580 EPERTNIQNL--NQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL 2637
+ + IQ L N+ + L D++ ++SE+E Q+ + L ++EI N+
Sbjct: 1817 KLQE-KIQELKANEHQLITLKKDVNETQKKVSEME-QLKKQIKDQSLTLSKLEIENLNLA 1874
Query: 2638 EKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2697
+K + LE E K KE+ + E LK + + + +LE ++ E
Sbjct: 1875 QKLHENLE--------EMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLE-IQQE 1925
Query: 2698 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2757
+ +KE +KL+E++ K ++ +QKDL + +D L + +
Sbjct: 1926 LKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDEL--------------QKK 1971
Query: 2758 VQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEV 2817
+QE +K K + + + D + N+ Q+ + +++QS V
Sbjct: 1972 IQELQK---------KELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQS------V 2016
Query: 2818 TEIISQFTEKI-EKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQ 2876
Q T+K+ E ++E+ E R I E+ ++R+ ++A TL+ +I
Sbjct: 2017 RMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIA---------TLREMIA 2067
Query: 2877 CLRSKEGSSIPELAHSDAYQ-----TREICSSDSG-----SDWGQGIYLTHSQGFDIASE 2926
R + SD Q RE CS S+ + D+ E
Sbjct: 2068 RDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE 2127
Query: 2927 GRGEESES----ATDSFP----KKIKGLLRAVHNEGMQ----------VLSLTESPYSDG 2968
++ S A S P K I+ L A M+ VLS + +
Sbjct: 2128 IEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYV-TKIKEE 2186
Query: 2969 EDHSIQQVSEPWLEERKAYINTISSLKDLITKMQ-LQREAEVYDSSQSHESFSDWRGELL 3027
+ SI + +++E + K+L+ K+Q LQ++ +V + +
Sbjct: 2187 QHESINKFEMDFIDE-------VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQ---NMD 2236
Query: 3028 LALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQ--------EQGVEYQAAM 3079
L ++++ + + +TE + ++ + LE+ + + G++ +
Sbjct: 2237 LHIEEILKDFSESEFPSIKTEFQQV-LSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDR 2295
Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESE----KPSQELLEYNIQQKQSQMLE 3135
C + + I + R T+ +E E + K E L N Q ++ +
Sbjct: 2296 ICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLAS 2355
Query: 3136 -MQVELSSMKDR---ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEA 3191
QV ++ ++ T QL++EK + EL++ L + K A HK K ++
Sbjct: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEK--IRELENSLHEAKES------AMHKESKIIKM 2407
Query: 3192 FRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA-------KLGRSEERDKEELED 3244
+ E+ + ND +A Q K E LEK K K+ + KEE+ED
Sbjct: 2408 QK--------ELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIED 2459
Query: 3245 LKFSL---ESQKQRNLQ--------LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEE-- 3291
LK L + +K +N + +E QK+++ ++ + + D + E
Sbjct: 2460 LKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHT 2519
Query: 3292 --QGRNLEL-------------QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSR 3336
Q N L ++L+SE +R+ + S L ++ E QL S
Sbjct: 2520 DPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNE---QLIKQKNELLSN 2576
Query: 3337 PPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQ 3392
S ++ ++ L+ + + V N + K+ ++++ Q + LQ
Sbjct: 2577 NQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQ 2632
Score = 195 bits (496), Expect = 6e-49
Identities = 473/2407 (19%), Positives = 984/2407 (40%), Gaps = 402/2407 (16%)
Query: 1431 LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNE 1490
LL+K E++E ++ S S+ Q+ + R K+ C + N+
Sbjct: 385 LLQKVQNEKIENLTRMLVTSSSLTLQQELKAKR-----------KRRVTWCLGK---INK 430
Query: 1491 MKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE 1550
MK S F + K + L +E+ E + S SD + + T+SE
Sbjct: 431 MKNSNYADQFNIPTNITTKTHKLSINLLREIDES----VCSESDVFS-----NTLDTLSE 481
Query: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610
++ + +++I E++ D L+L+ EQL ++E+ + +E E
Sbjct: 482 IEWNPATKLLNQENIESELNSLRADYDN-LVLDYEQLRTEKEEMELKLKEKNDLDEF--- 537
Query: 1611 AHMRQMERQ-REDQE-QLQEEIKRLNRQL--AQRSSIDNENLVSERERVLLEELEALKQL 1666
+ER+ ++DQE QL EI L + A+ + D EN +S + +L E+ + +K+L
Sbjct: 538 ---EALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKL 594
Query: 1667 SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKE--LDRKPEDVPPEILSNERYAL 1724
+ ++ + + E+ ++++ F + LD K E L
Sbjct: 595 QEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESA----------FL 644
Query: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784
+ N L + + E+ T +E I + +SQ A + + E ++S +
Sbjct: 645 RSENLELKEKMKELATTYKQMENDIQLY---------QSQLEAKKKMQVDLEKELQSAFN 695
Query: 1785 E--EHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL 1842
E + T + D +P D+ N + + K+T+ EL++ + + E+ +
Sbjct: 696 EITKLTSLIDGKVPK----DLLCN-LELEGKITDLQKELNKEVEENEALREEV------I 744
Query: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRER 1902
+L+ L + VE+L + I + S +L H ++ + + K+ + L
Sbjct: 745 LLSELKSLPSEVERLRKEIQDKSEEL-HIITSEKDKLFSEVVHKESRVQGL--------- 794
Query: 1903 LHEESRAREQLAVELSKAEGVIDGYADEKTL---FERQIQEKTDIIDRLEQELLCASN-- 1957
L E + ++ LA S + + + KTL FE++ + + +R+ QE++ S
Sbjct: 795 LEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854
Query: 1958 ----------------RLQELEAEQQQIQE---ERELLSRQKEAMKAEAGPVEQQLLQET 1998
+ QEL+ + +++QE E E L Q E + VE++ T
Sbjct: 855 QKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT 914
Query: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEI-------DVEEQVSRFIELEQEKNTELMDL 2051
EKL + EV+ ++ +DDL++ ++L+I D+ + V+ I+ +++ L L
Sbjct: 915 EKLQQTLEEVKTLTQE-KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973
Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHE---RDVFQQEI------QKLE----QQLKVVP 2098
+Q + + K+ + + E+ +D FQQ++ Q LE Q L
Sbjct: 974 KQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADV 1033
Query: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
+ I E Q R++ L E ++ KEQL+ D++E E + + +R L
Sbjct: 1034 KDNEIIEQQ-RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGD 1092
Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELS--------LEVQLQAERDAIDRKEKEITNLEE 2210
L + +++ H A++ + ELS +E +L+ + + K++++ N++E
Sbjct: 1093 ELKKQQEIV--AQEKNH--AIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQE 1148
Query: 2211 QLEQFRE---ELEN-----KNEEVQQLHMQ---LEIQKK--ESTTRLQELEQENKLFKD- 2256
++ + ++ E+EN KN+E+ HM+ LE+ +K E+ ++ + +E K+ K+
Sbjct: 1149 EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL 1208
Query: 2257 ----------------DMEKLGLAIKES---------DAMSTQDQ--HVLFGKFAQIIQE 2289
++E GL KE + T D+ + K AQII
Sbjct: 1209 QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINT 1268
Query: 2290 KEVEID--QLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREE 2347
+++E +L E++ L ++ ++ + K + E E + +LE E + E
Sbjct: 1269 QDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEM 1328
Query: 2348 EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE 2407
E +LNE ++ Q+E+ ++ ++ N ++ E + QL I E LA Q+ ++ E
Sbjct: 1329 ERLRLNEKFQESQEEIKSLTKERD-NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 2408 EMTFMKNVLKETNFKMNQLTQ-------------ELFSL-KRERESVEKIQSIPENSVNV 2453
+ MK ET ++++ Q E+ L KR +ES ++++S+ + ++
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447
Query: 2454 AI--DHLSKDKPELEVVLTEDALKSLENQTYFK-------SFEENGKGSIINL---ETRL 2501
+ L + +L+ + E K LE + K EE +NL ET +
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507
Query: 2502 LQLESTVSAKDLELTQCYKQIKDMQEQGQF-ETEMLQKKIVNLQKIVEEKVAAALVSQIQ 2560
++ + A + +L ++I + +EQ + +Q+K+ L++ E + A Q
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI 1567
Query: 2561 LEAVQEYAKFCQDNQT-----ISSEPERTNIQNLNQLREDELGSDISALTLRISELE--- 2612
+ E Q++Q I + E +Q Q+ D+L + + ++ E +
Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE 1627
Query: 2613 ---------SQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKK 2663
++ E + KEQ E + N+ E + + L ++L N ++ R K+
Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKE 1687
Query: 2664 RSP--QDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2721
R E LK + N +LE + E L ++E +KL+ +
Sbjct: 1688 RDDLRSVEETLKVERDQLKENLRETITRDLEK-QEELKIVHMHLKEHQETIDKLRGIVSE 1746
Query: 2722 KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQ 2781
K ++++QKDL D L K L+ ++E + E + KL ++ +
Sbjct: 1747 KTNEISNMQKDLEHSNDAL-----KAQDLKIQEELRIAHMHLKEQQETID-KLRGIVSEK 1800
Query: 2782 TDGTLKISSSNQTPQILVKNAGIQINLQSECSSEE----VTEIISQFTEKIEKMQELHAA 2837
TD SN + NA +Q +Q ++E + + +++ +K+ +M++L
Sbjct: 1801 TD-----KLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK- 1854
Query: 2838 EILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT 2897
+I D +S +S+ E E+ Q L E +K+V+ KE ++ + + +
Sbjct: 1855 QIKD-QSLTLSKLEI---ENLNLAQKLHENLEEMKSVM-----KERDNLRRVEETLKLER 1905
Query: 2898 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV 2957
++ S L ++ D+ + + + + + + L + + +Q+
Sbjct: 1906 DQLKES-----------LQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQI 1954
Query: 2958 LSLTES--PYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQS 3015
+ + D IQ++ + L+ + + S K + QL+++ E + S
Sbjct: 1955 SDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ 2014
Query: 3016 HESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEY 3075
++ +L L + E R ++A R EL +RI+E
Sbjct: 2015 SVRMDNF--QLTKKLHESLEEIR--IVAKERDEL----------------RRIKES---- 2050
Query: 3076 QAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLE 3135
K +R ++ ++ + A+ + + +K E+ Q+ L ++++K S++ E
Sbjct: 2051 -------LKMERDQFIATLREMIAR-DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE 2102
Query: 3136 MQVELSSMKDR-------ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3188
+ S M D + +L++++ +K + +K+ L+ L Q KH+++
Sbjct: 2103 LLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYL--------QTKHIEK 2154
Query: 3189 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDL-KF 3247
L + Q+ S E ++K K L + +E+ E + KF
Sbjct: 2155 L--------------------FTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF 2194
Query: 3248 SLESQKQRNLQLNLLLEQQKQLLNESQQKIES----QRMLYDAQLSEEQGRNLE--LQVL 3301
++ + +E+QK+LL + Q + R L D +L++ ++E L+
Sbjct: 2195 EMDFIDE--------VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDF 2246
Query: 3302 LESEKVRIR-EMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK----- 3355
ESE I+ E L +E+ L+ T E L +QK+ +
Sbjct: 2247 SESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTR-----FDIEKLKNGIQKENDRICQVNN 2301
Query: 3356 --HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVE 3413
++RI+ ++NE+ +++ S ++ E+D L++ +E N + K L++ +
Sbjct: 2302 FFNNRIIAIMNESTEFEERSATISKEWEQD-------LKSLKEKNEKLFKNYQTLKTSLA 2354
Query: 3414 DLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRES-----RRILYQNLNEPT 3468
Q+ Q + + Q ++ ++ E E +ES +I+
Sbjct: 2355 S-GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEV 2413
Query: 3469 TWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQV 3528
T + + K +TKE+ ++ G E+E ++ KL K+ +
Sbjct: 2414 TNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL----VKIDL 2469
Query: 3529 LPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPST--------- 3579
K ++ + E + + + Q+ + ++ + + QQ ++ S++S T
Sbjct: 2470 EKMKNAKEFEKEISATKATVEYQKEVIRLLRENLR-RSQQAQDTSVISEHTDPQPSNKPL 2528
Query: 3580 SCG---------------SLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYR 3624
+CG S RL ++ ++L QL ++KN+L + L +++ ++
Sbjct: 2529 TCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWK 2588
Query: 3625 QTGAGRD 3631
+ R+
Sbjct: 2589 ERTLKRE 2595
Score = 170 bits (430), Expect = 3e-41
Identities = 250/1236 (20%), Positives = 559/1236 (45%), Gaps = 184/1236 (14%)
Query: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTS-SSKHDVSAHHDLNIDQSQC 62
+E Q+K + +L + Q K Q + + + + ++ KT + K + + Q +
Sbjct: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD 932
Query: 63 NEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVEL----ESEISTTADDCSSEV 118
+ + S ++E + +S I T++ T + ++E + I+T S EV
Sbjct: 933 DLKQLQESLQIERDQL-KSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEV 991
Query: 119 N-GCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRE 177
+ TG+ + +++ G+D + ++ ++E+ +Q +I L +E
Sbjct: 992 SRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQE 1051
Query: 178 LEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQK 237
E++ Q E+ I +++ + T L N++ ++E L L K
Sbjct: 1052 KNELQ-----------QMLESVIAEKEQLKTDLKENIEMTIENQEE-----LRLLGDELK 1095
Query: 238 LQIQFQQLQASETLRNSTHSSTAAD-LLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTM 296
Q + + + ++ S D L + ++++ QQL+E+ L + Q+
Sbjct: 1096 KQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQE------- 1148
Query: 297 QISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTAD 356
++S +Q+KI ++EN K E++ KE +E + T+ +
Sbjct: 1149 EMSEMQKKI--------NEIENL-KNELKNKELTLEHMETERL----------------- 1182
Query: 357 KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
EL +++ + +E+K++ E K+ ++ E L G + E++ + + E
Sbjct: 1183 ----ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE-EL 1237
Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK-------- 468
I +E Q +++LR + E Q I Q+L + H EE+ H+
Sbjct: 1238 KIAHIHLKEHQETIDELRRSVSEKTAQII--NTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295
Query: 469 ------GEMENALRSYSNITVNEDQIKLMNVAIN--ELNIKLQDTNSQKEKLKEELGLIL 520
E N L + + +D L + + LN K Q++ + + L +E +
Sbjct: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355
Query: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580
K AL+ + + L E + RE + + +++ ++QE LN K T +IVS E
Sbjct: 1356 TIKEALEVKHDQLKEHI---RETLAKIQESQSKQEQSLNMKEKDNET-----TKIVSEME 1407
Query: 581 SRKELE---LKHEAEVTNYKIKLEMLEKEKNAV------LDRMAESQEAELERLR---TQ 628
K + L+ E E+ +L+ E +V L R+ E ++E ++L+ +
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467
Query: 629 LLFSH---EEELS------KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679
++ H EEEL K +E+ E R+N+ + + + ++Q++ + +++ KI+
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIST-IQKQLEAINDKLQNKIQ 1526
Query: 680 TMQFEKDNLITKQ--------NQL--ILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729
+ +++ KQ N+L E K KD + SK E+T ++ E Q+EI+
Sbjct: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586
Query: 730 ILRQEEKEKGTLEQ--EVQELQLKTELLEKQMKEKENDLQE-KFAQLEAENSILKDEKKT 786
I+ +E++E +++ +++ QLK E K KE+ +E +F ++ A N +T
Sbjct: 1587 IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVN-------ET 1639
Query: 787 LEDMLKI-HTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEK 845
E M +I H E + + L++I++++ + +IL E E+++ + K
Sbjct: 1640 QEKMCEIEHLKEQFETQKLNLENIETEN-----IRLTQILHENLEEMR--------SVTK 1686
Query: 846 QRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRI 905
+R+ E+ +V +L K++L ++ + +LE + +LK ++ +HL+
Sbjct: 1687 ERDDLRSVEETLKVERDQL----------KENLRETITR-DLEKQEELKIVH--MHLKEH 1733
Query: 906 NPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELS-QRLSDLSE 964
T K++ V ++ E M + +E + + ++ ++ +E+L ++ L + E
Sbjct: 1734 QETIDKLRGIVSEKTN----EISNMQKDLE-HSNDALKAQDLKIQEELRIAHMHLKEQQE 1788
Query: 965 QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV 1024
+ + G +S +++ +++++ E + + +E + + +++ + Q+ +L V
Sbjct: 1789 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE--------KIQELKANEHQLITLKKDVN 1840
Query: 1025 TMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKE-SS 1083
+ +E + ++ K ++S + K+ EN+ + ++ + L+ + SV KE +
Sbjct: 1841 ETQKKVSE--MEQLKKQIKDQS--LTLSKLEIENLNLAQKLHEN---LEEMKSVMKERDN 1893
Query: 1084 LRATQPS---ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
LR + + E D+L++ L K+ +++ +++ R+ LS + VD++RE + +EK
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM-LSKEHKETVDKLREKI-SEKT 1951
Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176
+ ++++L +++E K++Q++ + ELQ ++ +E
Sbjct: 1952 IQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKE 1987
Score = 149 bits (376), Expect = 5e-35
Identities = 377/1865 (20%), Positives = 766/1865 (41%), Gaps = 265/1865 (14%)
Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP 1989
+ T + ++ ++ R +E++ +L+E+ E + E++ L++ E
Sbjct: 330 KNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLE-------- 381
Query: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI-ELEQEKNTEL 2048
E+ LLQ K+ EK+E + L Q + L+ + +V+ + ++ + KN+
Sbjct: 382 -EKDLLQ---KVQNEKIENLTRMLVTSSSLTLQ-QELKAKRKRRVTWCLGKINKMKNSNY 436
Query: 2049 MDLRQQNQALEKQLEKMR----KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104
D + + K+ + +DE E DVF + L + + P +
Sbjct: 437 ADQFNIPTNITTKTHKLSINLLREIDESVCS---ESDVFSNTLDTLSEI-----EWNPAT 488
Query: 2105 EHQTRE-VEQLANHLKEKTDKC----SELLLSKEQLQRDIQERNE--EIEKLEFRVR-EL 2156
+ +E +E N L+ D +L KE+++ ++E+N+ E E LE + + +
Sbjct: 489 KLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ 548
Query: 2157 EQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKE------ITNLEE 2210
E L+ + + + + ELS +V+L E++ +K +E + N++
Sbjct: 549 EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM 608
Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIK--ES 2268
L E +E+ + Q L E ++ L EN K+ M++L K E+
Sbjct: 609 DLSYSLESIEDPKQMKQTL-FDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEN 667
Query: 2269 DAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL--KITTDNKVIEEKNELIRD 2326
D Q Q + K Q+ EKE++ NE +TKL + K+ D E I D
Sbjct: 668 DIQLYQSQ-LEAKKKMQVDLEKELQ-SAFNE-ITKLTSLIDGKVPKDLLCNLELEGKITD 724
Query: 2327 LETQIECLMSDQECVKRNREE-----EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
L+ ++ + + E + REE E++ L +E+L++E+ Q S H ++ E
Sbjct: 725 LQKELNKEVEENEAL---REEVILLSELKSLPSEVERLRKEI----QDKSEELHIITSEK 777
Query: 2382 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2441
D L +E + E +V+ EE+ K+ L T QE + K E
Sbjct: 778 DKL-------FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFE 830
Query: 2442 KIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRL 2501
+ + ++VL E+ + E K ++ ++ L
Sbjct: 831 Q---------------------KYKMVLEENERMNQEIVNLSKEAQK--------FDSSL 861
Query: 2502 LQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL 2561
L++ +S K EL + +++++ + + E L+ + LQ + EK L+++
Sbjct: 862 GALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKT---LITEKLQ 918
Query: 2562 EAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTS 2621
+ ++E Q+ + +Q Q+ D+L SDI + + Q+ S
Sbjct: 919 QTLEEVKTLTQEKDDLKQ------LQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES 972
Query: 2622 LILEKEQVEIAEKNVLEKEKKLLELQKLL-EGNEKKQREKEKKRSPQDVEVLKTTTELFH 2680
L +E + + + E+ + L +++ E ++ Q++ QD+E T T
Sbjct: 973 LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTAD 1032
Query: 2681 SNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHL 2740
+ E + + ++ S ++ +LQ+ L L+ DL + +
Sbjct: 1033 VKDN------------EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080
Query: 2741 AEAKEKLSIL----EKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQ 2796
E +E+L +L +K+ E QE A E +LS++ + K+ +Q Q
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEG---ELSRTCDRLAEVEEKLKEKSQ--Q 1135
Query: 2797 ILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKRE 2856
+ K + +N+Q E +S+ +KI +++ L +++++ ++ E ++ E
Sbjct: 1136 LQEKQQQL-LNVQEE---------MSEMQKKINEIENLKN----ELKNKELT-LEHMETE 1180
Query: 2857 HYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLT 2916
Q L E +K++ +KE + EL S ++T D +G Y+
Sbjct: 1181 RLELAQKLNENYEEVKSI-----TKERKVLKELQKS--FETER--------DHLRG-YIR 1224
Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
+ + ++ + + + I L R+V + Q+++ + S H+ Q
Sbjct: 1225 EIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKS----HTKLQE 1280
Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQREAEVY-DSSQSHESFSDWRGEL-LLALQQVF 3034
P L E + + ++K++ + E E+ + S + +S + R E+ L L + F
Sbjct: 1281 EIPVLHEEQ---ELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337
Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI 3094
E + + + + +A L +++E E A ++ Q +SL +
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEA---LEVKHDQLKEHIRETLAKIQESQSKQEQSLNMK- 1393
Query: 3095 QALHAQMNGRKITLKREQESEKPSQEL-LEYNIQQKQSQMLEMQVELSSM---KDRATEL 3150
KI + EQ K S L +E + ++ E E+ S+ KD L
Sbjct: 1394 ---EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRL 1450
Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE----AFRLEVKDKTDEVHLL 3206
QE L SE + E E+ LE E LK H LKE E R+ + +K E+ +
Sbjct: 1451 QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTI 1510
Query: 3207 NDTL-ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ 3265
L A K ++Q EKE+ + +E++ +LK E +K ++ L
Sbjct: 1511 QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSAL------ 1564
Query: 3266 QKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3325
Q IES+ + +L E Q E+Q++++ EK ++ + L ER+ Q
Sbjct: 1565 ---------QSIESKMLELTNRLQESQE---EIQIMIK-EKEEMKRVQEALQIERD---Q 1608
Query: 3326 LQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRI-VELLNETEKYKLDSLQTRQQMEKDR 3384
L+ + +++++ ++++ E+++ + + +NET++ + ++Q E +
Sbjct: 1609 LKEN-----------TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE-TQ 1656
Query: 3385 QVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQ 3444
+++ + ++TE N + +HE ++ + ++ ++ R L +E +L+ ++E
Sbjct: 1657 KLNLENIETE---NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI 1713
Query: 3445 KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ-----KIEGETKESNYAKLI 3499
++L EK+E +I++ +L E T D+ R V ++ ++ + + SN A
Sbjct: 1714 TRDL---EKQEELKIVHMHLKEHQE---TIDKLRGIVSEKTNEISNMQKDLEHSNDA--- 1764
Query: 3500 EMNGGGTGCNHELEMIRQKL---QCVASKLQVLPQKASERLQFETADDEDF-IWVQENID 3555
+ EL + L Q KL+ + + +++L D E+ +QE I
Sbjct: 1765 -LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQ 1823
Query: 3556 EIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMK 3615
E+ +L + + V+ + S E+L +Q + + +S+L E N+ K
Sbjct: 1824 ELKANEHQLITLKKD----VNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN---LNLAQK 1876
Query: 3616 LEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK 3675
L E + + RDN R +E E+ L++SL+ +A +
Sbjct: 1877 LHENLEEMKSVMKERDNLRRV---------------EETLKLERDQLKESLQETKARDLE 1921
Query: 3676 LKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDA 3735
++ EL+ +L ++ ++I K ++ +K L K L + QE +
Sbjct: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKI---QELQKK 1978
Query: 3736 TLALL 3740
L LL
Sbjct: 1979 ELQLL 1983
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 230 bits (586), Expect = 2e-59
Identities = 461/2386 (19%), Positives = 993/2386 (41%), Gaps = 346/2386 (14%)
Query: 236 QKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFT 295
QK+ + QQLQ + ++ +S+ ++++ T Q + D Q +
Sbjct: 7 QKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQ 66
Query: 296 MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL-KDKLTT 354
+++ ++ ++ + + S+ +E + + E LN ++ + + D +
Sbjct: 67 LRVPSVES---LFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSE 123
Query: 355 ADKLLGEL----QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK 410
A+ L+G +EQ++Q+ ++ M+ L++ + K + + T ++ +R K
Sbjct: 124 AEDLVGNSDSLNKEQLIQR---LRRMERSLSSYRGKYSE--------LVTAYQMLQREKK 172
Query: 411 DSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGE 470
Q I+ + + ++ R++ +LR EL Q Q K+ L + A +EE K +
Sbjct: 173 KLQ---GILSQSQDKSLRRIAELREEL-----QMDQQAKKHLQEEFDASLEE-----KDQ 219
Query: 471 MENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS--QKEKLKEELGLILEEKCALQR 528
+ L++ ++ + MNV + + +L+ KE+ E G + E +
Sbjct: 220 YISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279
Query: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
LE L + + ++R ++TI + + +++ E + E K+L +
Sbjct: 280 TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA 339
Query: 589 HEA----EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDL 644
+ ++ + K +E LE++K V+ AE +R + L EEE+++L+ +
Sbjct: 340 EKTKLITQLRDAKNLIEQLEQDKGMVI--------AETKRQMHETLEMKEEEIAQLRSRI 391
Query: 645 EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD-NLITKQNQLILEISKLK 703
+ + E+L++ Q E S++ + EK + K + ++
Sbjct: 392 K-QMTTQGEELRE-------------QKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437
Query: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE--KGTLEQEVQELQLKTELLEKQMKE 761
D Q + SEE + LQ+E+ ++QE + K + E+++ +LQ +L EK++
Sbjct: 438 DEQIKTIEKTSEEERIS---LQQELSRVKQEVVDVMKKSSEEQIAKLQ---KLHEKELAR 491
Query: 762 KENDLQEKFAQLEAE--NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE 819
KE +L +K E E + +K+ + LKI Q+E L L+ ++ + K + E
Sbjct: 492 KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA-LEELELQKKAILTE 550
Query: 820 KEIEI--LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY-----ACLL 872
E ++ L +E E + + ++L +EK K+ V+ + + ++ +
Sbjct: 551 SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610
Query: 873 KVKDDLEDSKNKQELEYKSKLKALNEELH--LQRINPTTVKMKSSVF-DEDKTFVAETLE 929
K K +LE K++Q+ + KL+ L ++ ++++ + K ++ D++ F A E
Sbjct: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
Query: 930 MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989
M E + +EKL+V + E LS S+LSE LK +H L EE+ LK + ++
Sbjct: 671 MNE-------KTLEKLDVKQTELESLS---SELSEVLKARHK----LEEELSVLKDQTDK 716
Query: 990 VSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM 1049
+ +ELE ++ + + Q D+ + + + T + + ++++ E K +
Sbjct: 717 MK---QELEAKMDEQKNHHQQQVDSIIKE-HEVSIQRTEKALKDQINQLELLLKERDKHL 772
Query: 1050 VEDKVSFENMTVGEESKQEQL--------ILDHLPSVTKESSLRATQPSENDKLQKELNV 1101
E + EN+ + + +L + S T E + + +LQ++L
Sbjct: 773 KEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT--KAYEEQLAQLQQKLLD 830
Query: 1102 LKSEQNDLRLQ---MEAQRICLSLVYSTHVDQVREYME------NEKDKALCSLKEELIF 1152
L++E+ L Q +EAQ+ + H QV++ M+ +E ++ + SL +
Sbjct: 831 LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYES 890
Query: 1153 AQEEKIKELQKIHQL--ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVL 1210
E+ KE ++ Q+ E + M Q + K + +L KL + E+ + +L
Sbjct: 891 KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL--SAKEDSIH-------IL 941
Query: 1211 GEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKL 1270
E Y K N++ +++ + + ++ QE TL K+ ++ KL
Sbjct: 942 NEEYETKFK-----------------NQEKKMEKVKQKAKEMQE---TLKKKLLDQEAKL 981
Query: 1271 LVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQD 1330
+ Q+ + +F + L + I ++ LE N K ++ SL +
Sbjct: 982 KKELENTALELSQK----EKQFNAKMLEMAQANSAGISDAVSRLE---TNQKEQIESLTE 1034
Query: 1331 LEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVV 1390
+ + +L + + E L QQ +E ++ +E + LQ++ Q V+E
Sbjct: 1035 VHRRELNDVISIWE---KKLNQQAEELQEIHEIQ---LQEKEQEVAEL------------ 1076
Query: 1391 ITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVS 1450
Q+ + G C K+ ++ I + E GVK++T + +L E+ Q+ +
Sbjct: 1077 -----KQKILLFG-CEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
Query: 1451 MSIAFAQQTELSRISGGKENTASSKQ---AHAVCQQEQHYFNEM--KLSQDQIGFQTFET 1505
A ++ E+ KENT +Q + ++++ +E+ KL FQ+ ++
Sbjct: 1131 KLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS 1190
Query: 1506 VDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSI 1565
K + + S E + +E L I ++ K ++
Sbjct: 1191 SHEKSNKSLEDKSLEFKKLSEE------------------LAIQLDICCKKTEALLEAKT 1232
Query: 1566 HDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ 1625
++ I++SS + +L+ R V++ + T +A +RQ+ E+Q
Sbjct: 1233 NELINISS--SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL---TEEQNT 1287
Query: 1626 LQEEIKRLNRQLAQRSS------IDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
L ++ QL ++ + D E+LV+E+E + + E Q A ++ C
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---QKEGGNQQQAASEKESCI--- 1341
Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVV 1739
TQ E + T ++EL K ++ LS +
Sbjct: 1342 -----TQLKKELSENINAVTLMKEELKEKKVEI--SSLSKQ------------------- 1375
Query: 1740 KTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE-SIPSY 1798
+ D + + Q+S SL + A +S++ EE + D+ S+
Sbjct: 1376 ----------------LTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSF 1419
Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEK-- 1856
+ + I+ +V + + S+ ++ T+ +EL + + + + A EK
Sbjct: 1420 KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDE 1479
Query: 1857 ----LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQ 1912
L E + + + + + K + + +++ LK Q R+ E Q
Sbjct: 1480 QINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ---TARIMELEDHITQ 1536
Query: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE 1972
+E+ V+ Y +K + +++ +K L +E NR++E E E+
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEE---KDNRVKEAE-------EK 1586
Query: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032
L Q +MKAE +++L + ++ E++ +++ + ++ L+ E+
Sbjct: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646
Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE- 2091
+++ K L + ++ + +K E L+ + +RE E + +++++ +E
Sbjct: 1647 KIAAI------KKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700
Query: 2092 --QQLKVVPRFQPISEHQTREVEQLANHLKEKT--DKCSEL---LLSKEQLQRDIQERNE 2144
+ +VPR T + E + +KT +K S L L KE+L + + + E
Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE 1760
Query: 2145 EIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKE 2204
E F +R Q L+ + E ++H + S+ LQ E + ++K
Sbjct: 1761 ETVSSHFEMRCQYQERLIK---LEHAEAKQH-------EDQSMIGHLQEELEEKNKKYSL 1810
Query: 2205 ITNLEEQLE------QFREELENKNEEVQQLHMQLEIQKKESTTRLQELE----QENKLF 2254
I + E Q ++ LEN ++VQ+ + E+ + +++EL+ ++ ++
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Query: 2255 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2314
+ +ME+L ++ A+ D K ++++E E + + KL ++ ++
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGR---NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHND 1927
Query: 2315 ---KVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQL-----NEVIEKLQQELANI 2366
K+ + E + L +I L D +++ ++E+E L E EK++QE ++
Sbjct: 1928 LEFKLAGAEREK-QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986
Query: 2367 GQKTSMNAHSLSEEADS----LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422
K + L E ++ + +L++ I E + Q+VE +++ +ETN
Sbjct: 1987 ELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEA-----ELLESHQEETNQL 2041
Query: 2423 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2482
+ ++ ++ LKR + E+I E + + L EL+ K + +
Sbjct: 2042 LKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ--------KKYQQKLE 2093
Query: 2483 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
+ N +I+ L+T+L Q + +S L+ + +QI +++++
Sbjct: 2094 QEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDR 2139
Score = 223 bits (568), Expect = 3e-57
Identities = 451/2272 (19%), Positives = 930/2272 (40%), Gaps = 397/2272 (17%)
Query: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKE--IEILRQEEKEKGTLEQEVQELQL 750
N+L L+ S S ++S++E++ + L KE I+ LR+ E+ + + EL
Sbjct: 103 NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT 162
Query: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
++L+++ K+ + L + + + L++E + ++ K H QEE F S++
Sbjct: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQ-MDQQAKKHL---QEE---FDASLE 215
Query: 811 SKSKD-SVWEKEIEILIEE------NEDLKQQCIQLNEEIE---KQRNTFSFAE------ 854
K + SV + ++ +L + N D+ + QL + E K+ N S E
Sbjct: 216 EKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDG 275
Query: 855 ---KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL-----HLQRIN 906
K E Q ++ + L + K+ ++ K + L S+ +AL E+L L++I
Sbjct: 276 TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL-LTSEKEALQEQLDERLQELEKIK 334
Query: 907 PTTVKMKSSVFDE--DKTFVAETLEM--GEVVEKDTTELMEKLEVTKREKLELSQRLSDL 962
+ K+ + + D + E LE G V+ + ++ E LE+ + E +L R+ +
Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394
Query: 963 SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDG 1022
+ Q EE++ K++ E+ + ELE ++ A+ + ++ + +D
Sbjct: 395 TTQ-----------GEELREQKEKSERAAFE--ELEKALS--TAQKTEEARRKLKAEMDE 439
Query: 1023 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKES 1082
+ + +E E+++S + E S+ +Q ++D + ++E
Sbjct: 440 QIKTIEKTSE------------------EERISLQQ----ELSRVKQEVVDVMKKSSEEQ 477
Query: 1083 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142
+ + E + +KE + K Q + RE+ E K
Sbjct: 478 IAKLQKLHEKELARKEQELTKKLQT----------------------REREFQEQMKVAL 515
Query: 1143 LCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202
S E L +QE++ +E + +LELQ +KA+ E
Sbjct: 516 EKSQSEYLKISQEKEQQESLALEELELQ---------------------KKAILTESENK 554
Query: 1203 LQTLCSVLGEYYTPALKCEVNAE----DKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258
L+ L Y T L+ E + E + +N ++ + + E + E+ E T
Sbjct: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614
Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318
L + + + L W ++ +K ++ E E+ + T L+D +
Sbjct: 615 ELESLKHQQDAL----------WTEKLQVLKQQYQTE---MEKLREKCEQEKETLLKDKE 661
Query: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
+ ++ + + + KL+ + ELESL S L + LK H L++ L + +
Sbjct: 662 IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR--------HKLEEELSVLKDQ 713
Query: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQE 1438
T +++ + E S +K++ + +I+ + E +K++ N ++LL K+ +
Sbjct: 714 TDKMKQELEAKM-DEQKNHHQQQVDSIIKEH-EVSIQRT-EKALKDQINQLELLLKERDK 770
Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQI 1498
L+E QAH + +E +L Q
Sbjct: 771 HLKEH--------------------------------QAHVENLEADIKRSEGELQQASA 798
Query: 1499 GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558
F++ E+ K ++L + +++L ++
Sbjct: 799 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLL----------------------DLETERI 836
Query: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
+ +Q E+ D +L ++ Q++D+ Q+L +Q E +Q + L Q + ++E
Sbjct: 837 LLTKQVA--EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
Query: 1619 QREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678
++QEQ ++ + ++ EN++ + +E+E L Q A + + +
Sbjct: 895 GNKEQEQTKQIL------------VEKENMILQMREGQKKEIEILTQKLSAKEDSI--HI 940
Query: 1679 RNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738
N +T+ N+ + ++E+ K KE+ E + ++L E ++ N L++ +
Sbjct: 941 LNEEYETKFKNQEK-KMEKVKQKAKEMQ---ETLKKKLLDQEAKLKKELENTALELSQKE 996
Query: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
+ A + E + GI D S+ +++ S E + + + ++ +
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL--NDVISIWEKKLNQQ 1054
Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL--MLNISSRLQAAVEK 1856
+ ++I + K +E EL Q+++ G E + N+E+ + + + +
Sbjct: 1055 AEELQEIHEIQLQEK-EQEVAELKQKIL---LFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110
Query: 1857 LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL-------HEESRA 1909
L E + + S+ + +T+L + + + +SLK L+E+L E+ R
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRK 1170
Query: 1910 REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL-----LCASNRLQELEA 1964
+L +L + + +++K+ +L +EL +C LEA
Sbjct: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA 1230
Query: 1965 EQQQI-----QEERELLSR----------QKEAM---KAEAGPVEQQLLQETEKLMKEKL 2006
+ ++ + +LSR KEA+ +E QL Q TE+ +
Sbjct: 1231 KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
Query: 2007 EVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ--LEK 2064
Q QA ++ + Q+K+++ D+E V+ L++E QQ A EK+ + +
Sbjct: 1291 SFQ-QATHQLEEKENQIKSMKADIESLVTEKEALQKEGG------NQQQAASEKESCITQ 1343
Query: 2065 MRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLAN--HLKEKT 2122
++K L E ++ + K E + K V +S+ T QL N L EK
Sbjct: 1344 LKKELSE---------NINAVTLMKEELKEKKV-EISSLSKQLTDLNVQLQNSISLSEKE 1393
Query: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVED-RKHFGAVEA 2181
S L ++Q + E ++++ L F+V L + + ++V+D F +
Sbjct: 1394 AAISSL---RKQYDEEKCELLDQVQDLSFKVDTLSKEKI---SALEQVDDWSNKFSEWKK 1447
Query: 2182 KPE----------LSLEVQLQAERDAIDRKEKEITNLEEQLEQ-------FREELENKNE 2224
K + L++QL+ + K+++I L+E+L+Q + E+E+
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKS 1507
Query: 2225 EVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFA 2284
++++ LE + K T R+ ELE ++E L +K +
Sbjct: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN--------------- 1552
Query: 2285 QIIQEKEVEIDQLNEQVTKLQ--QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2342
Q+K++E +L V KLQ Q+L DN+V +E E I LE Q+ + ++ E
Sbjct: 1553 ---QQKDIEHKEL---VQKLQHFQELGEEKDNRV-KEAEEKILTLENQVYSMKAELE--- 1602
Query: 2343 RNREEEIEQLNEVIEKLQQELANIGQK-TSMNAHSLSEEADSLKHQLDVVIA--EKLALE 2399
+++E+E +N ++ ++EL + + S +A L+E LK + + IA +K L
Sbjct: 1603 -TKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE----LKRKAEQKIAAIKKQLLS 1657
Query: 2400 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS----IPENSVNVAI 2455
Q E + ++ L E N K+ + +E+ L+ + +SVE QS +P ++ NVA
Sbjct: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA- 1716
Query: 2456 DHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSI-INLETRLLQLESTVSAKDLE 2514
Y + E + +G + E ++ L+ ++ K+ +
Sbjct: 1717 -------------------------AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE-K 1750
Query: 2515 LTQCYKQIKDMQEQGQFETE-MLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQ 2572
L Q Q K+ FE Q++++ L+ ++ +++ +Q E ++ K+
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810
Query: 2573 -DNQTISSEPERTNIQNLNQLRE--DELGSDISALTLRISELESQVVEMHTSLILEKEQV 2629
Q + E + NIQ L D++ + L LE ++ E+ + L+ +KE
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Query: 2630 EIAEKNVLEKEKKLLELQKLLEGNEK-----KQREKEKKRSPQDVEVLKTTTELFHSNEE 2684
+ + + K +KL LQ+ ++G K ++ +EK +S L + E H++ E
Sbjct: 1871 RVEMEELTSKYEKLQALQQ-MDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLE 1929
Query: 2685 ---SGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLA 2741
+G E + L E V + +L + K + + E+L KE + +K + D
Sbjct: 1930 FKLAGAEREKQKLGKEIVRLQKDLRMLR-KEHQQELEILKKEYDQEREEKIKQEQEDLEL 1988
Query: 2742 EAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
+ L L +E T++ + ++ + IK + + A + + L S +T Q+L K
Sbjct: 1989 KHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045
Query: 2802 AGIQINLQS---------ECSSEEVTEIISQFTEKIEKMQELHAAEILDMES 2844
A +L+ + EE+T + ++E++Q+ + ++ E+
Sbjct: 2046 AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097
Score = 218 bits (555), Expect = 9e-56
Identities = 399/1886 (21%), Positives = 822/1886 (43%), Gaps = 314/1886 (16%)
Query: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
LEM E E+A + I+++ + EE+R +E E A+ ++
Sbjct: 377 LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL--------STAQKTEE 428
Query: 217 ARR----EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT 272
ARR E DE ++ +E T + +++ +Q + + + + + S+ + AK Q L
Sbjct: 429 ARRKLKAEMDEQIKT-IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQI--AKLQKLH 485
Query: 273 HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV-YEMEQDKKVENSNKEEIQEKETII 331
++ ++ L + Q ++ +F QE++KV E Q + ++ S ++E QE +
Sbjct: 486 EKELARKEQELTKKLQTREREF-------QEQMKVALEKSQSEYLKISQEKEQQESLALE 538
Query: 332 E-ELNTKII--EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKER 388
E EL K I E E K +L+ + T + EL+ + + QE KN +L + E
Sbjct: 539 ELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL--AVHLEA 596
Query: 389 QSSEEIKQLMGTVE----ELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 444
+ ++ K++ VE EL+ H+ T+ +Q ++Q+ Q ++E+LR E E +
Sbjct: 597 EKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR-EKCEQEKET 655
Query: 445 IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504
+++ K+ + + H+ +M E + L S S+ + +K + EL++
Sbjct: 656 LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL--SEVLKARHKLEEELSVLKDQ 713
Query: 505 TNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRA-RQTIAEQESKLNEAHK 563
T+ K++L+ ++ E+K Q+Q++ +++E S ++ ++A + I + E L E K
Sbjct: 714 TDKMKQELEAKMD---EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770
Query: 564 SL----STVEDLKAEIVSASESRKELELK-----------------HEAEVTNYKIKLEM 602
L + VE+L+A+I + ++ K +E ++ + KL
Sbjct: 771 HLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830
Query: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662
LE E+ + ++AE EA+ + + T+ L +H+ ++ L + LE ++ +K+K ++
Sbjct: 831 LETERILLTKQVAE-VEAQKKDVCTE-LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
Query: 663 YKQQIDGLQNEMSQKIETMQFEKDNLITK----QNQLILEISKLKDLQQSLVNSKSEEMT 718
+ DG N+ ++ + + EK+N+I + Q + I +++ ++ ++ +EE
Sbjct: 889 ESKLEDG--NKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946
Query: 719 LQINELQKEIEILRQEEKE-KGTLEQEV--QELQLKTEL--LEKQMKEKENDLQEKFAQL 773
+ +K++E ++Q+ KE + TL++++ QE +LK EL ++ +KE K ++
Sbjct: 947 TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006
Query: 774 EAENSI-LKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD---SVWEKEIEILIEEN 829
NS + D LE +Q+E++ L + + + S+WEK++ EE
Sbjct: 1007 AQANSAGISDAVSRLE--------TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
Query: 830 EDLKQQCIQLNEEIEKQRNTFSFAEK--NFEVNYQELQEEYACLLK--VKDDLEDSKNKQ 885
+++ + IQL EK++ +K F +E+ +E L + VK D ++ ++
Sbjct: 1059 QEIHE--IQLQ---EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQE 1113
Query: 886 ELEYKS-----------KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL-EMGEV 933
+L+ KS KLKA HL+++ V + S+ ++ TF+ E L E+ +
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKA-----HLEKLE---VDLNKSL--KENTFLQEQLVELKML 1163
Query: 934 VEKD---TTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990
E+D +EL KL+ T E L ++ L+ K E L+EE+ Q+
Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI------QL 1217
Query: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE---------GSVSKVNKS 1041
+ C++ E ++ E + ++ +++L + R + +VS++
Sbjct: 1218 DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQ 1277
Query: 1042 FGEESKIMVEDKVSFENMTVGEESKQEQL---------ILDHLPSVTKESSLRATQPSEN 1092
+ ++ +SF+ T E K+ Q+ ++ ++ KE + SE
Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
Query: 1093 D----KLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMEN-----EKDKAL 1143
+ +L+KEL+ + ++ +++ +++ +S + S + + ++N EK+ A+
Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEKKVEISSL-SKQLTDLNVQLQNSISLSEKEAAI 1396
Query: 1144 CSLKEELIFAQEEKIKELQKIHQLELQT-MKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202
SL+++ EEK + L ++ L + ++E + + K + + S F
Sbjct: 1397 SSLRKQY---DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRF 1453
Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDP----------ELQDYRYEVQDF 1252
Q +V LK + A +K+ + + E D E++D + +++
Sbjct: 1454 TQHQNTVKELQIQLELKSK-EAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKK 1512
Query: 1253 QENMHT------------------------LLNKVTEEYN-------KLLVLQTRLSKIW 1281
+ N+ T LN+V + YN K LV + + +
Sbjct: 1513 ESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQEL 1572
Query: 1282 GQQTDGMKLEFGEENLPKEETEF---LSIHSQMTNLEDIDVNHKSKLSSLQDLE------ 1332
G++ D E E+ L E + + ++ LE ++++ KSK L+ LE
Sbjct: 1573 GEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE 1632
Query: 1333 -KTKLEEQVQELESLISSLQQQL----KETEQNY------------------EAEIHCLQ 1369
KL E ++ E I+++++QL +E E+ Y E E+H L+
Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692
Query: 1370 KRLQAV----SESTVPPSLPVDSVVITESD-------AQRTMYPG-SCVKKNI------- 1410
++L++V SE+ + P + TE + Q+T S +++N+
Sbjct: 1693 EKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLL 1752
Query: 1411 -------DGTIEFSGEFGVKEETNIVKLLE---KQYQEQ-----LEEEVAKVIVSMSIAF 1455
+ T+ E + + ++KL KQ+++Q L+EE+ + S+
Sbjct: 1753 QRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIV 1812
Query: 1456 AQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD---VKFKE 1512
AQ E GGK N + + V Q E +L+ QI Q + +D V+ KE
Sbjct: 1813 AQHVEK---EGGKNNIQAKQNLENVFDDVQKTLQEKELT-CQILEQKIKELDSCLVRQKE 1868
Query: 1513 EFKPLSKEL-GEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISV 1571
+ +EL ++ K L D + P + E K K+ +V+ + +
Sbjct: 1869 VHRVEMEELTSKYEKLQALQQMDGRNKPTE-----LLEENTEEKSKSHLVQPKLLSNMEA 1923
Query: 1572 SSMDASRQLMLNEEQLEDMRQELVRQY-------QEHQQATELLRQAHMRQMERQ-REDQ 1623
D +L E + + + +E+VR +EHQQ E+L++ + ++ E + +++Q
Sbjct: 1924 QHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQ 1983
Query: 1624 EQLQ--------EEIKRLNRQLAQRS---SIDNENLVSERERVLLEELEALKQLSLAGRE 1672
E L+ + ++ N QLAQ+ + + +++ + V E LE+ ++ + +
Sbjct: 1984 EDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLK 2043
Query: 1673 KLCCELRNSSTQTQNGNEN--QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNR 1730
K+ E + +T E EE T K ++L + E++ + ++ Q+ N
Sbjct: 2044 KI-AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKY---QQKLEQEENPG 2099
Query: 1731 LLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRV 1790
+ + ++T A + T+ I D K Q I E +E++
Sbjct: 2100 NDNVTIMELQTQLAQKTTL------ISDSKLKEQEFREQIHNLEDRLK----KYEKNVYA 2149
Query: 1791 TDESIPSYSGSDMPRNDINMWSKVTE 1816
T P Y G ++ D++++ + TE
Sbjct: 2150 TTVGTP-YKGGNLYHTDVSLFGEPTE 2174
Score = 199 bits (505), Expect = 6e-50
Identities = 461/2180 (21%), Positives = 910/2180 (41%), Gaps = 375/2180 (17%)
Query: 1762 KSQSSASLIWRSEAEASVKSCVHEEHTRVT-DESIPSY---SGSDMPRNDINMWSKVTEE 1817
+S SL S E+ V++ E R+ D S S+ S D D+ + + +
Sbjct: 77 RSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDL-VGNSDSLN 135
Query: 1818 GTELSQRLVR-----SGFAGTEIDPENEELMLNISSR-----LQAAVEKLLEAISETSSQ 1867
+L QRL R S + G + ML + L + +K L I+E +
Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195
Query: 1868 LEHAKVTQTELMRE---SFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924
L+ + + L E S +K + L+ Q L ++ + L + E
Sbjct: 196 LQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQA 255
Query: 1925 DGYADEKTLF---ERQIQEKTDI--IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 1979
+ + E+ E +++ T + ++ L+Q + N L+ + Q +E+ LL+ +
Sbjct: 256 EVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSE 315
Query: 1980 KEAMKAEAGPVEQQLLQETEKL----MKEKLEVQCQ---AEKVRDDLQKQVKALEIDVEE 2032
KEA++ + + LQE EK+ M EK ++ Q A+ + + L++ + + +
Sbjct: 316 KEALQEQL----DERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR 371
Query: 2033 QVSRFIELEQEKNTELM-----------DLRQQN--------QALEKQL----------E 2063
Q+ +E+++E+ +L +LR+Q + LEK L
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431
Query: 2064 KMRKFLDEQ--AIDR--EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK 2119
K++ +DEQ I++ E ER QQE+ +++Q+ VV + SE Q ++++L H K
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQE--VVDVMKKSSEEQIAKLQKL--HEK 487
Query: 2120 EKTDKCSELLLSKEQLQRDIQER------------------NEEIEKLEFRVRELEQALL 2161
E K EL + +R+ QE+ E+ E L EL++ +
Sbjct: 488 ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI 547
Query: 2162 VS------ADTFQKVED-RKHFGAVEAKPELSLE----------VQLQAERDAIDRKEKE 2204
++ D Q+ E R +E+ E SL+ V L+AE+ ++ KE
Sbjct: 548 LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEK---NKHNKE 604
Query: 2205 ITNLEEQLEQFREELENKNEEVQQLHMQ-LEIQKKESTTRLQEL----EQENK-LFKD-- 2256
IT + +E+ + ELE+ + L + L++ K++ T +++L EQE + L KD
Sbjct: 605 ITVM---VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKE 661
Query: 2257 -------------DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 2303
+EKL + E +++S++ VL + + E E+ L +Q K
Sbjct: 662 IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR-----HKLEEELSVLKDQTDK 716
Query: 2304 LQQQLKITTDNK-----------------VIEEKNELIRDLETQIECLMSDQECVKRNRE 2346
++Q+L+ D + I+ + ++D Q+E L+ +++ + +
Sbjct: 717 MKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQ 776
Query: 2347 EEIEQLNEVIEKLQQELANIGQK----------TSMNAHSLSEEADSLKHQLDVVIAEKL 2396
+E L I++ + EL K T + E+ L+ +L + E++
Sbjct: 777 AHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERI 836
Query: 2397 ALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAID 2456
L +QV + + L ++ L Q+L K+ E +K++S+ + ++
Sbjct: 837 LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL--EKQNSEMEQKVKSLTQ-VYESKLE 893
Query: 2457 HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELT 2516
+K++ + + +L +E + E K I L +L E ++ + E
Sbjct: 894 DGNKEQEQTKQIL-------VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946
Query: 2517 QCYK-QIKDMQEQGQFETEM---LQKKIVNLQ-KIVEEKVAAAL-VSQIQLEAVQEYAKF 2570
+K Q K M++ Q EM L+KK+++ + K+ +E AL +SQ + + + +
Sbjct: 947 TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006
Query: 2571 CQDNQTISSEP-------ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI 2623
Q N S+ ++ I++L ++ EL IS ++++ ++ E+H +
Sbjct: 1007 AQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL 1066
Query: 2624 LEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE 2683
EKEQ E+AE L+ + LL G EK++ KE + E +K T L E
Sbjct: 1067 QEKEQ-EVAE----------LKQKILLFGCEKEEMNKEITWLKE--EGVKQDTTLNELQE 1113
Query: 2684 ESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEA 2743
+L+ A + + K EKL+ +L T LQ+ L +++ E
Sbjct: 1114 ------QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED 1167
Query: 2744 KEKLSILEKEDETEVQE----------SKKACMFEPLPI-KLSKSIASQTDGTLKISSSN 2792
K K+S L + +T +E S K+ + L KLS+ +A Q D K
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK----- 1222
Query: 2793 QTPQILVKNAGIQINLQSECSSEEVTEI--ISQFTEKIEKMQELHAAEILDMES--RHIS 2848
+T +L IN+ S ++ ++ I T K+++ + + ++E+ R ++
Sbjct: 1223 KTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLT 1282
Query: 2849 ETE-TLKREHYVAVQLLKE---ECGTLKAVIQCL-RSKEGSSIPELAHSDAYQTREICSS 2903
E + TL A L+E + ++KA I+ L KE A +E C +
Sbjct: 1283 EEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCIT 1342
Query: 2904 DSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTES 2963
+ + I ++ +E + S K++ L + N +SL+E
Sbjct: 1343 QLKKELSENINAVTLMKEEL------KEKKVEISSLSKQLTDLNVQLQNS----ISLSE- 1391
Query: 2964 PYSDGEDHSIQQVSEPWLEERKAYINTISSLK---DLITKMQLQREAEVYDSSQSHESFS 3020
++ +I + + + EE+ ++ + L D ++K ++ +V D S FS
Sbjct: 1392 -----KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWS---NKFS 1443
Query: 3021 DWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAME 3080
+W+ + A + + +V + EL + + +N L++ + +Q + +
Sbjct: 1444 EWKKK---AQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRF----D 1496
Query: 3081 CLQ---KADRRSLLSEIQALHAQMNGRKITL--------KREQESEKPSQELLEYNIQQK 3129
CL+ + D+ + + L ++ + + ++ E E ++ L YN QQK
Sbjct: 1497 CLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN-QQK 1555
Query: 3130 QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL 3189
+ E+ +L ++ E ++ + + L++++ K ELET KEL
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET-------KKKEL 1608
Query: 3190 EAFRLEVKDKTDEVHLLNDTLASE--------QKKSRELQWALEKE-KAKLGRSEERDKE 3240
E L VK K +E+ L D L SE ++K+ + A++K+ +++ EE+ K+
Sbjct: 1609 EHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK 1668
Query: 3241 ELEDLKFSLESQ-KQRNLQLNLLLEQQKQLLNE------------------SQQKIESQ- 3280
E L ++ ++R ++++L E+ K + + Q++ +SQ
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728
Query: 3281 --RMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPP 3338
+ Y+ ++S Q E + LL+ +E T+ E+ Q Q +
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVG---QEKEETVSSHFEMRCQYQERLIKLEHAEA 1785
Query: 3339 LPSED--LLKELQKQLEE---KHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3393
ED ++ LQ++LEE K+S IV E E K +++Q +Q +E +KTLQ
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGK-NNIQAKQNLENVFDDVQKTLQE 1844
Query: 3394 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ---EFQKQELER 3450
++ ++K+ EL S L RQ E R ++ +L + ++LQ + Q + EL
Sbjct: 1845 KELTCQILEQKIKELDS---CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
Query: 3451 EEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNH 3510
E E + +L +P L++ ++ L+ K+ G +E ++
Sbjct: 1902 ENTEEKSK---SHLVQPKL--LSNMEAQHNDLEFKLAGAEREKQ-----KLGKEIVRLQK 1951
Query: 3511 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQEN--IDEIILQLQKLTGQQ 3568
+L M+R++ Q +L++L ++ + + + +++ + ++ N + +++ + Q+
Sbjct: 1952 DLRMLRKEHQ---QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
Query: 3569 GEEPSLVSPST--SCGSLTERLLRQNAELTGHISQLTEEKND------------------ 3608
+E + T + LL + E T + + EK+D
Sbjct: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068
Query: 3609 -----LRNMVMKLEEQIRWYRQ-----TGAGRDNSSRFSLNGGANIEAIIASE---KEVW 3655
+R++ +LEE + Y+Q G DN + L + + S+ KE
Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
Query: 3656 NREKL-TLQKSLKRAEAEVY 3674
RE++ L+ LK+ E VY
Sbjct: 2129 FREQIHNLEDRLKKYEKNVY 2148
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 214 bits (544), Expect = 2e-54
Identities = 506/2519 (20%), Positives = 1033/2519 (41%), Gaps = 399/2519 (15%)
Query: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
EQ+ +Q +AE ++ K+ + +A +V K +A+V Y+ +
Sbjct: 22 EQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVR----------KLQAKVLQYRSWCQ 71
Query: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI--EHRINIEKLK--- 656
LEK A + + E E +LL EEE + + E+ + R+++EK
Sbjct: 72 ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVN 131
Query: 657 -------DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI------------- 696
+ L + + + D L + SQ +F K L + +L+
Sbjct: 132 KALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191
Query: 697 LEISKLKDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEKGTLEQEVQE------L 748
LE+ D + L+ K+E + L + L + + Q + G+ + +E L
Sbjct: 192 LEMKSATD--RDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLL 249
Query: 749 QLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808
KT+ LEK+ E+ +L + +Q + E + L+D L +L SQ++ +
Sbjct: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALL----TQSQKQNEDYEKM 305
Query: 809 IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868
IK+ + +EIL + +L + L+ ++++ + K+ E +
Sbjct: 306 IKA------LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNI 359
Query: 869 ACLLKVKDDLE-DSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAET 927
A ++ LE DS + +Y+ KAL + SV + V +
Sbjct: 360 AQGSGHENSLELDSSIFSQFDYQDADKALT--------------LVRSVLTRRRQAVQDL 405
Query: 928 LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEK 987
+ ++ L ++ + + E L QRL L+ + G+ L EV SL +E+
Sbjct: 406 RQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKER 465
Query: 988 EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK 1047
E + EL + ++ + + L V + +G K + EE
Sbjct: 466 ELLQKAREELR--------QQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQ--EELH 515
Query: 1048 IMVEDKVSFENMTVGEESKQEQ------LILDHLPSVTKESSLRATQPSEND----KLQK 1097
+ V ++ + M +G E+KQ + + + L S E L + +E + ++
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 1098 ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEK---DKALCSLKEE--LIF 1152
+ L S +N L+ ++ R + + + E + +K ++ L L+EE +
Sbjct: 576 SIAELSSSENTLKTEVADLRAA-----AVKLSALNEALALDKVGLNQQLLQLEEENQSVC 630
Query: 1153 AQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGE 1212
++ E ++ + Q++L + + K H L +LQKA
Sbjct: 631 SRMEAAEQARNALQVDLAEAEKRREALWEKNTH-LEAQLQKAE----------------- 672
Query: 1213 YYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLV 1272
E AE + + D E E E+Q E + QE T L ++ +E +
Sbjct: 673 --------EAGAELQADLRDIQEEKE--EIQKKLSESRHQQEAATTQLEQLHQEAKR--- 719
Query: 1273 LQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSK-LSSLQDL 1331
Q + + E+ E L + Q + D+ + + LSS ++L
Sbjct: 720 -----------QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL 768
Query: 1332 EKTKLEEQVQELESLISSLQQQLK-------ETEQNYEAEIHCLQKRLQAV-SESTVPPS 1383
++ L E Q+ S+I + QL+ + ++ + E+ CL+ L S++
Sbjct: 769 LESSLFE-AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD 827
Query: 1384 LPVDSVVITESDAQRTMYPGSCV-KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442
+ E + + + +K ++ E + + + K LE +E++E
Sbjct: 828 AAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMEL 887
Query: 1443 EVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQT 1502
E+ QQTE+ I +E + ++ A+CQ M+L ++
Sbjct: 888 EMR--------LKEQQTEMEAIQAQREEERTQAES-ALCQ--------MQLETEKERVSL 930
Query: 1503 FETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVR 1562
ET+ ++ ++E S++L E L + + E + + ++ ++ +
Sbjct: 931 LETL-LQTQKELADASQQL-----ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
Query: 1563 QSIHDEISVSSMDASRQL---MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619
+ D+++ ++S L M ++Q+ED++ +LV Q ++ L + +++ R+
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA-----QDDSQRLVEQEVQEKLRE 1039
Query: 1620 REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
++ ++Q+E++R +++S+ + E+ ++L+E ++++Q L
Sbjct: 1040 TQEYNRIQKELER------EKASLTLSLMEKEQRLLVLQEADSIRQQEL----------- 1082
Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK-----ANNRLLKI 1734
S Q+ E QGE +E + + + L ++ ++ + L+ E L++ + L+
Sbjct: 1083 --SALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRA 1140
Query: 1735 LLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDES 1794
L + AA + R L+ + Q + AS+ S + + V ES
Sbjct: 1141 SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVC-ES 1199
Query: 1795 IPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV 1854
P SG + ++W G E Q RS F + L+ +S+
Sbjct: 1200 RPELSGGG--DSAPSVW------GLEPDQNGARSLF-------KRGPLLTALSA------ 1238
Query: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914
EA++ +L H + +T+ R+ R + ++L ERL + + Q+
Sbjct: 1239 ----EAVASALHKL-HQDLWKTQQTRDVLRDQ---------VQKLEERLTDTEAEKSQVH 1284
Query: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974
EL + + +EK+ +E + + L + + +RL+ E ++ + Q ERE
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344
Query: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK---VRDDLQKQVKALEIDVE 2031
LL KE + A + E L +E + QA + +DL+ AL++ E
Sbjct: 1345 LLQAAKENLTA-----------QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
Query: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091
E +E E+E+ L + + A K L++ L + +RE E + + +IQ+LE
Sbjct: 1394 E-----VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE 1448
Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151
+Q E Q +E L+ LK++ E+ L +EQ+Q ++++ +E L
Sbjct: 1449 KQ----------REMQKAALELLSLDLKKRN---QEVDLQQEQIQ-ELEKCRSVLEHLPM 1494
Query: 2152 RVRELEQALLVSADTFQKVE-DRKHFGAVEAKPELSLEVQ---LQAERDAIDRKEKEITN 2207
V+E EQ L V + +++E DR+ V L LE + ++++R + +K++
Sbjct: 1495 AVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVT 1554
Query: 2208 LE---EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2264
LE +LE+ ++E + + +++L Q E Q+ T +LE+ ++ +++
Sbjct: 1555 LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ----ELQAQSSQ 1610
Query: 2265 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI 2324
I + ++ ST A+ +QE++ E+ EQ+ +LQ+Q K L
Sbjct: 1611 IHDLESHST--------VLARELQERDQEVKSQREQIEELQRQ------------KEHLT 1650
Query: 2325 RDLETQIECLMSDQECVKRNREEEIEQ---LNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
+DLE + + LM +E ++ ++ Q L E +E+++ L G++ + + E A
Sbjct: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
Query: 2382 D-----------SLKHQLDVVIAEKLALEQQVETANE---EMTFMKNVLK---------- 2417
+ SL+H + +++ +K E++VE E E+ +K+ L+
Sbjct: 1711 EEGKGPSKAQRGSLEH-MKLILRDK---EKEVECQQEHIHELQELKDQLEQQLQGLHRKV 1766
Query: 2418 -ETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKS 2476
ET+ ++Q QE+ L+++ + + + E S+ +D + + + L +AL+
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL--EALQQ 1824
Query: 2477 LENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFE---T 2533
+ Q + EE K L+ L Q T+ + EL +Q + ++E+ E
Sbjct: 1825 EQQQA--QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRV 1882
Query: 2534 EMLQKKIVNLQKIVEEKVAAALVSQIQ-LEAVQEY---AKFCQDNQTISSEPERTNIQNL 2589
+ L++ + +L+ E+ A L Q Q E QE+ + QD+ + + Q L
Sbjct: 1883 QALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQEL 1942
Query: 2590 NQLREDELGS--DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEK--EKKLLE 2645
LR + S A R L+ + + H + L+ ++ + E+ L + E
Sbjct: 1943 EALRAESQSSRHQEEAARARAEALQEALGKAHAA--LQGKEQHLLEQAELSRSLEASTAT 2000
Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL 2705
LQ L+ + R+ E+ Q+ E+ +++ + +++ L+ +++A + E
Sbjct: 2001 LQASLDACQAHSRQLEEALRIQEGEI---------QDQDLRYQEDVQQLQ-QALAQRDEE 2050
Query: 2706 ASYKEKAEKLQEELLVK--ETNMTSLQKDLSQVRD-------HLAEAKEKLSILEKEDE- 2755
++++ E+L E+ L + + NM +++L Q R+ H + + +L++ +KE E
Sbjct: 2051 LRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEI 2110
Query: 2756 TEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSE 2815
E++E+++ E LP S + + +LK+ S Q ++ LQ+
Sbjct: 2111 LELRETQQRNNLEALP--HSHKTSPMEEQSLKLDSLEPRLQRELE------RLQAALRQT 2162
Query: 2816 EVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVI 2875
E EI E EK Q+L L + S + + ++ +L+ + +
Sbjct: 2163 EAREI-----EWREKAQDL----ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQD 2213
Query: 2876 QCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESES 2934
+ ++ L A T E+ GS QG+ L G + G E +S
Sbjct: 2214 ELELTRRALEKERLHSPGATSTAEL-----GSRGEQGVQLGEVSGVEAEPSPDGMEKQS 2267
Score = 197 bits (500), Expect = 2e-49
Identities = 464/2377 (19%), Positives = 966/2377 (40%), Gaps = 372/2377 (15%)
Query: 164 LAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDE 223
L K E+E+ E + + ++G + E + + T+L+A L Q++++ ++
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRV-------TELSALLTQSQKQNED 301
Query: 224 TMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHL 283
+ L E + L+ +L E + L Q + I Q +EE D++
Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDIT--QVMVEEGDNI 359
Query: 284 LE------------------DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
+ DYQ + T+ S L + + QD + + + Q
Sbjct: 360 AQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAV---QDLRQQLAG---CQ 413
Query: 326 EKETIIEELNTKIIEEEKKTLELKDKLT-TADKLLGEL------------QEQIVQKNQE 372
E ++++ + + EE K + KLT D L G+ + +++QK +E
Sbjct: 414 EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473
Query: 373 IKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQ 432
+LE+ + + QL G + QK ++ Q E + R + Q L
Sbjct: 474 ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQK---EEQQEELHLAVRERERLQEMLMG 530
Query: 433 LRAELDEMYGQQIVQMKQELIRQHMAQ--MEEMKTRHKGEMENALRSYSNITVNEDQIKL 490
L A+ E + ++ +++ L H+ + + +T + A +S + ++ +E+ +K
Sbjct: 531 LEAKQSESLSE-LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589
Query: 491 MNVAINELNIKLQDTNS----QKEKLKEELGLILEEK---CALQRQLEDLVEELSFSREQ 543
+ +KL N K L ++L + EE C+ E L +
Sbjct: 590 EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAE 649
Query: 544 IQRARQTIAEQESKLN-EAHKSLSTVEDLKAEIVSASESRKELELK-----HEAEVTNYK 597
++ R+ + E+ + L + K+ +L+A++ E ++E++ K H+ E +
Sbjct: 650 AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709
Query: 598 IK-LEMLEKEKNAVLDRMAESQEAELER-----LRTQLLFSHEEELSKLKEDLEIEHRIN 651
++ L K + VL R + +EA + +R Q + ++L++ + L +
Sbjct: 710 LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS-----S 764
Query: 652 IEKLKDNLGIHYKQQ---IDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQS 708
++L ++ +QQ I+ + ++ +I+T+ K+ + + L LE+ D ++S
Sbjct: 765 AKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL----DTERS 820
Query: 709 LVNSKSEEMTLQINELQKEIEILRQE-----EKEKGTLEQE--------VQELQLKTELL 755
+ + Q+ + ++E + ++ EKE L ++ QEL E L
Sbjct: 821 QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESL 880
Query: 756 EKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD 815
E++ E E L+E+ ++EA + ++E+ E L +++ER+ L+++ K+
Sbjct: 881 EREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940
Query: 816 -SVWEKEIEILIEENEDLKQQCIQ-------LNEEIEKQRNTFSFAEKNFEVNYQELQEE 867
+ +++E L +D+K Q ++ L ++++ + A + + LQEE
Sbjct: 941 LADASQQLERL---RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
Query: 868 YACLLKVKDDL--------------EDSKNKQELEYKSKLKALNEELHLQR-INPTTVKM 912
+ LL+ K DL +DS+ E E + KL+ E +Q+ + +
Sbjct: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
Query: 913 KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972
S+ ++++ + E + +++ + L + ++ + E+ ELS ++ L +++K+K E
Sbjct: 1058 TLSLMEKEQRLLV-LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK--E 1114
Query: 973 ISFLNEEVKSLKQ--------------------EKEQVSLRCR----ELEIIINHNRAEN 1008
FL +E + L++ + Q+ LR R +LE + + N
Sbjct: 1115 ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174
Query: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSV--SKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
Q++SL + + A GSV S+ S G +S V +N G S
Sbjct: 1175 QAQAQAQLASLYSAL-----QQALGSVCESRPELSGGGDSAPSVWGLEPDQN---GARSL 1226
Query: 1067 QEQLILDHLPSVTKESSLRATQPSEND--KLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124
++ L L +++ E+ A D K Q+ +VL+ + L ++ S V+
Sbjct: 1227 FKRGPL--LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284
Query: 1125 STHVDQVREYMENEKDKALC-----SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179
+ D R+ +N+++K+ SL+ EL+ E ++ + ELQ M+ Q G+
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ--GE 1342
Query: 1180 EGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYIS-ENE 1238
+L +A E + ++ L + + E A + ED + + +NE
Sbjct: 1343 R---------ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
Query: 1239 DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL--VLQTRLSKIWGQQTDGMKLEFGEEN 1296
+ E + R + Q + K +E LL L R ++ + +LE +
Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE-KQRE 1452
Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK-----LEEQVQELESLISSLQ 1351
+ K E LS+ + N +++D+ + +Q+LEK + L VQE E ++ +
Sbjct: 1453 MQKAALELLSLDLKKRN-QEVDLQQE----QIQELEKCRSVLEHLPMAVQEREQKLTVQR 1507
Query: 1352 QQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNID 1411
+Q++E E++ E + + L+ +L + + ++S D ++ + C+ ++
Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKK----DQMIESQRGQVQDLKKQLVTLECLALELE 1563
Query: 1412 GTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENT 1471
++ + ++K LE Q + Q VA +++ + Q E
Sbjct: 1564 -----ENHHKMECQQKLIKELEGQRETQ---RVALTHLTLDLEERSQ----------ELQ 1605
Query: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLS 1531
A S Q H + E++ ++ Q + +++ ++E L+++L +E++L
Sbjct: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEH--LTQDLERRDQELML- 1662
Query: 1532 NSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMR 1591
K+ + + ++ + K I+ + + ++I +S + R+L + +++
Sbjct: 1663 ---------QKERIQVLEDQRTRQTK--ILEEDL-EQIKLSLRERGRELTTQRQLMQERA 1710
Query: 1592 QE------LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL--AQRSSI 1643
+E R EH +L+ + +++E Q+E +LQE +L +QL R
Sbjct: 1711 EEGKGPSKAQRGSLEHM---KLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
Query: 1644 DNENLVSERER---VLLEELEALKQLSLAGREKLCCEL---------RNSSTQTQNGNEN 1691
+ L+S+RE+ VL ++L+ ++ + L +L R+ + +
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYA-LQKANNRLLKILLEVV---KTTAAVEE 1747
Q + +E+ KEK + + ER+ LQ + ++ E+ + A+EE
Sbjct: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887
Query: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807
VLG L S+ Q A L + + + HE TR +S
Sbjct: 1888 -----VLGDLRAESREQEKALLALQQQCAEQAQE--HEVETRALQDS------------- 1927
Query: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ 1867
W + E Q L + L A S++S
Sbjct: 1928 ---WLQAQAVLKERDQEL------------------------------EALRAESQSSRH 1954
Query: 1868 LEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGY 1927
E A + E ++E+ + A + + + L E++ +L+ L + +
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKE------QHLLEQA----ELSRSLEASTATLQAS 2004
Query: 1928 ADEKTLFERQIQEKTDIIDR--LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985
D RQ++E I + +Q+L + Q +A Q+ +E R R++ K+
Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064
Query: 1986 EAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDV---EEQVSRFIELEQ 2042
A V++ ++QE + L +E+ E E++R L + V+ L++ + E+++ E +Q
Sbjct: 2065 LAQRVQENMIQEKQNLGQEREE-----EEIR-GLHQSVRELQLTLAQKEQEILELRETQQ 2118
Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102
N E + + +E+Q K+ D + +Q+ ++L+ R
Sbjct: 2119 RNNLEALPHSHKTSPMEEQSLKL---------------DSLEPRLQRELERLQAALRQTE 2163
Query: 2103 ISEHQTRE-VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161
E + RE + LA L + S L LQ + ER+ E ++L+ + +AL
Sbjct: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL- 2222
Query: 2162 VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2221
++R H + EL + + + E E + + + +R+ LE+
Sbjct: 2223 --------EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEH 2274
Query: 2222 KNEEVQQLHM---QLEIQKKESTTRLQELEQENKLFKDDMEKL----GLAIKESDAMS-- 2272
+ V +L + +L+ + + L+++E+E + K + + L I ++ A S
Sbjct: 2275 LQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPT 2334
Query: 2273 TQDQHVLFGKFAQIIQEKEVEIDQLNEQVT--KLQQQLKITTDNKVIEEKNELIRDLETQ 2330
QD A+ + E + E+ L Q+T + Q+Q IT + E L L
Sbjct: 2335 QQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHS 2394
Query: 2331 IECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2367
+ + E E E +L+ E L Q L + G
Sbjct: 2395 LLAVAQAPEATV--LEAETRRLD---ESLTQSLTSPG 2426
Score = 191 bits (485), Expect = 1e-47
Identities = 494/2349 (21%), Positives = 931/2349 (39%), Gaps = 391/2349 (16%)
Query: 1324 KLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPS 1383
+L S DLEK +L+++V EL +L++ Q+Q ++YE I L+
Sbjct: 269 QLKSQGDLEKAELQDRVTELSALLTQSQKQ----NEDYEKMIKALR-------------- 310
Query: 1384 LPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEE 1443
++V I E++ M + + +N EK +Q+ ++
Sbjct: 311 ---ETVEILETNHTELMEHEASLSRNAQE--------------------EKLSLQQVIKD 347
Query: 1444 VAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTF 1503
+ +V+V AQ G EN+ + + F++
Sbjct: 348 ITQVMVEEGDNIAQ-------GSGHENSL---------ELDSSIFSQFDYQDADKALTLV 391
Query: 1504 ETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQ 1563
+V + ++ + L ++L + + L HD E + L + + ++ + Q
Sbjct: 392 RSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ-HDQWEEEGKALRQRLQKLTGERDTLAGQ 450
Query: 1564 SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE----HQQATELLRQAHMRQMERQ 1619
++ + V S+ R+L+ ++ E++RQ+L QE + EL Q Q +++
Sbjct: 451 TVDLQGEVDSLSKERELL--QKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKE 508
Query: 1620 REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
E QE+L ++ R+ Q + E SE L+ EAL+ L G E L E
Sbjct: 509 -EQQEELHLAVRE--RERLQEMLMGLEAKQSESLSELITLREALESSHLEG-ELLRQEQT 564
Query: 1680 NSSTQTQNGNENQGEVE--EQTFKEKELDRKPEDVPPEILSNERYALQKA--NNRLLKIL 1735
+ ++ E+ E T K + D + V L NE AL K N +LL++
Sbjct: 565 EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL-NEALALDKVGLNQQLLQLE 623
Query: 1736 LE---VVKTTAAVEETIGRHVLGILDRSSKSQS--------SASLIWRSEAEASVKSCVH 1784
E V A E+ + + + + ++ A L EA A +++ +
Sbjct: 624 EENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLR 683
Query: 1785 ------EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE----GTELSQRLVRSGFAGT- 1833
EE + ES + ++ +K EE + + LVR A
Sbjct: 684 DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEV 743
Query: 1834 ---EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVT--QTELMRESFRQKQE 1888
++ + ++L + L +A E L ++ E Q +VT Q E+ ++ Q +E
Sbjct: 744 RLQAVERDRQDLAEQLQG-LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKE 802
Query: 1889 ATES-LKCQE-ELRERLHEESRAREQLAVELSKAEGV-IDGYADEKTLFERQI------- 1938
+ ++C + EL + + R+ A +L++AE +K E+++
Sbjct: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKW 862
Query: 1939 --------QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
QE ++ LE+E + RL+E + E + IQ +RE +E +AE+
Sbjct: 863 EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE-----EERTQAESALC 917
Query: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
+ QL ETEK LE Q +K D +Q++ L D++ Q + E T+L +
Sbjct: 918 QMQL--ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQE 975
Query: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
+++ + +Q L E++ ++ Q++++ L+ QL + R
Sbjct: 976 AQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA-------QDDSQRL 1028
Query: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV--SADTFQ 2168
VEQ + E L ++ R +E E L + E EQ LLV AD+ +
Sbjct: 1029 VEQ----------EVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 2169 KVE-DRKHFGAVEAKPE-LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEV 2226
+ E EA+ E L Q++ R + KE + E QL EELE +
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL---LEELEASHITE 1135
Query: 2227 QQLH----------MQLEIQKKESTTRLQELEQENK-------------LFKDDMEKLGL 2263
QQL QL+++ + + ++L+ L E + L+ + LG
Sbjct: 1136 QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195
Query: 2264 AIKESDAMS------------TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2311
+ +S DQ+ F + + + + + KL Q L T
Sbjct: 1196 VCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKT 1255
Query: 2312 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN-IGQKT 2370
++ +++RD ++E ++D E K E++ L + + Q+E + G++
Sbjct: 1256 ------QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN 1309
Query: 2371 SMNAH--SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
S+ + L E SL+ +L + A Q++E E + +L+ + +
Sbjct: 1310 SLESELMELHETMASLQSRL------RRAELQRMEAQGE-----RELLQAAKENLTAQVE 1358
Query: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2488
L + E + I E + A L E+E + ++L+ Q K +
Sbjct: 1359 HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVE--SERERAQALQEQGELKVAQ- 1415
Query: 2489 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
GK L+ L L T++ ++ E+ QI+++++Q + + L+ ++L+K +
Sbjct: 1416 -GKA----LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQ 1470
Query: 2549 EKVAAALVSQIQLEAVQEYAKFCQD-----NQTISSEPERTNIQNLNQLREDELGSDISA 2603
E +Q E +QE K C+ + ++ +Q Q+RE E +
Sbjct: 1471 E-------VDLQQEQIQELEK-CRSVLEHLPMAVQEREQKLTVQR-EQIRELEKDRETQR 1521
Query: 2604 LTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQK---LLEGNEKKQ 2657
+ LE Q++E+ + ++ QV+ +K ++ E LEL++ +E +K
Sbjct: 1522 -----NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLI 1576
Query: 2658 REKEKKRSPQDVEVLKTTTELFHSNEE-SGFFNELEALRAESVATKAELASYKEKAEKLQ 2716
+E E +R Q V + T +L ++E +++ L + S EL ++ + +
Sbjct: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQR 1636
Query: 2717 EELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILE--KEDETEVQESKKACMFEPLPIKL 2774
E++ + L +DL + L KE++ +LE + +T++ E E + + L
Sbjct: 1637 EQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED----LEQIKLSL 1692
Query: 2775 ---SKSIASQTDGTLKISSSNQTPQILVKNAGIQINL-------QSECSSEEVTEIISQF 2824
+ + +Q + + + P + + + L + EC E + E+
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK 1752
Query: 2825 TEKIEKMQELHAAEILDMESRHISETETL--KREHYVAV--QLLKE--ECGTLKAVIQCL 2878
+ +++Q LH R + ET L +RE + V Q L+E E G LK Q L
Sbjct: 1753 DQLEQQLQGLH---------RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE--QSL 1801
Query: 2879 RSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ----------------GIYLT----HS 2918
+S+ + LA D Q E + GQ ++T H
Sbjct: 1802 QSQLDEAQRALAQRD--QELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG 1859
Query: 2919 QGFDIASEGRGEESESATD----SFPKKIKGLLRAVHNEGMQ-VLSLTESPYSDGEDHSI 2973
+ D + R E E A + +++ G LRA E + +L+L + ++H +
Sbjct: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
Query: 2974 Q--QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQ 3031
+ + + WL+ + L+ L + Q R E +++ E+ + G+ ALQ
Sbjct: 1920 ETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARA-EALQEALGKAHAALQ 1978
Query: 3032 ---QVFLEERSVLLAAFRTELTALGTTDAV--------GLLNCLEQRIQEQGVEYQAAME 3080
Q LE+ + + + T + DA L E IQ+Q + YQ ++
Sbjct: 1979 GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQ 2038
Query: 3081 CLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKP-SQELLEYNIQQKQSQMLEM-QV 3138
LQ+A L + L Q +REQ EK +Q + E IQ+KQ+ E +
Sbjct: 2039 QLQQA----LAQRDEELRHQQ-------EREQLLEKSLAQRVQENMIQEKQNLGQEREEE 2087
Query: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK-HLKELEAFRLEVK 3197
E+ + ELQ L+ ++ + EL+ + LE L HK E ++ +L+
Sbjct: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLE---ALPHSHKTSPMEEQSLKLDSL 2144
Query: 3198 DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ--R 3255
+ + L A Q ++RE++W +E+ +DL SL K
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEW----------------REKAQDLALSLAQTKASVS 2188
Query: 3256 NLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSST 3315
+LQ + Q L +S+Q QR+ + +L+ LE E++ +ST
Sbjct: 2189 SLQEVAMFLQASVLERDSEQ----QRLQDELELTRR---------ALEKERLHSPGATST 2235
Query: 3316 LDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3375
+ +Q + +G P P + +++LE + L + + + ++Q
Sbjct: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295
Query: 3376 TR---QQMEKDR----------------QVHRKTLQTEQEANTEGQKK-----MHELQSK 3411
R +Q+E++R ++ + T + + + GQK + ELQ +
Sbjct: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355
Query: 3412 VEDLQRQ--LEEKRQQVY--KLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQ--NLN 3465
V LQ Q LE K++Q Y + + L G+ L + E+ + + L+
Sbjct: 2356 VVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLD 2415
Query: 3466 EPTTWSLTS 3474
E T SLTS
Sbjct: 2416 ESLTQSLTS 2424
Score = 173 bits (438), Expect = 3e-42
Identities = 396/1958 (20%), Positives = 803/1958 (41%), Gaps = 307/1958 (15%)
Query: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870
W + E+ E + + + E +P +EL++ + Q E+++E ++QL
Sbjct: 69 WCQELEKRLEATGGPIPQRWENVE-EPNLDELLVRLEEEQQRC-----ESLAEVNTQLR- 121
Query: 1871 AKVTQTELMRESFRQKQE--ATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA 1928
+ + +++ ++ R+ E + + ++EL + + +E L G +
Sbjct: 122 LHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLW 181
Query: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRL---------------QELEAEQQQIQEER 1973
E F R E DR EL RL Q E + R
Sbjct: 182 REVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGR 241
Query: 1974 E-----LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQ----------CQAEKVRDD 2018
E LL + + ++ EA Q+L+Q + EK E+Q Q++K +D
Sbjct: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED 301
Query: 2019 LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID--- 2075
+K +KAL VE + EL + + + + +++ +L++ ++ + + + E+ +
Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 2076 -------REHERDVF----------------------QQEIQKLEQQL----KVVPRFQP 2102
E + +F +Q +Q L QQL + V Q
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ 421
Query: 2103 ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162
+ E + L L++ T + L LQ ++ ++E E L+ EL Q L V
Sbjct: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
Query: 2163 SADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE-- 2220
++ +++E+QLQ + + + Q E+ +EEL
Sbjct: 482 LEQEAWRLR------------RVNVELQLQGD------------SAQGQKEEQQEELHLA 517
Query: 2221 -NKNEEVQQLHMQLEIQKKESTTRLQELEQ-------ENKLFKDDMEKLGLAI---KESD 2269
+ E +Q++ M LE ++ ES + L L + E +L + + ++ A+ ++S
Sbjct: 518 VRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSI 577
Query: 2270 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNE-----QVTKLQQQLKITTDNKVIEEKNELI 2324
A + ++ L + A + + V++ LNE +V QQ L++ +N+ + + E
Sbjct: 578 AELSSSENTLKTEVADL-RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAA 636
Query: 2325 RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSL 2384
++ +++ E R E + + N +E Q+ G + + + EE + +
Sbjct: 637 EQARNALQVDLAEAE----KRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
Query: 2385 KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE-KI 2443
+ +L ++ A Q+E ++E + VL QE +L RE+ ++E ++
Sbjct: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARA-------VQEKEALVREKAALEVRL 745
Query: 2444 QSIPENSVNVA--IDHLSKDKPELEVVLTE-----DALKSLENQTYFKSFEENGKGSIIN 2496
Q++ + ++A + LS K LE L E ++ + Q + +I
Sbjct: 746 QAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805
Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
E R L+LE D E +Q +Q +D + + E K + QK EK L
Sbjct: 806 GEVRCLKLEL-----DTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLR 859
Query: 2557 SQIQLEAV---QEYAKFCQDNQTISSEPE------RTNIQNLNQLREDELGSDISALTLR 2607
+ + E QE AK + + E E +T ++ + RE+E SAL
Sbjct: 860 EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
Query: 2608 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ 2667
E E + V + +L+ ++++ A + LE+ ++ +++QKL K++E Q
Sbjct: 920 QLETEKERVSLLETLLQTQKELADASQQ-LERLRQDMKVQKL------KEQETTGILQTQ 972
Query: 2668 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2727
E + E + + +L AL+ ES + + +++ E L+ +L+ ++ +
Sbjct: 973 LQEAQRELKEAARQHRD-----DLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027
Query: 2728 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLK 2787
++++ V++ L E +E + ++KE E E KA + L K + + Q +++
Sbjct: 1028 LVEQE---VQEKLRETQE-YNRIQKELERE-----KASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 2788 ISSSNQTPQILVKNAGIQ--INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR 2845
+ Q + + G Q ++ Q E +EV E + F + ++ E ++E+
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE-------ELEAS 1131
Query: 2846 HISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDS 2905
HI+E + + L +E + ++ LRS E S + LA + +
Sbjct: 1132 HITEQQ-------LRASLWAQEAKAAQLQLR-LRSTE-SQLEALAAEQQPGNQAQAQAQL 1182
Query: 2906 GSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGL------LRAVHNEGMQVLS 2959
S +Y Q E R E S DS P + GL R++ G + +
Sbjct: 1183 AS-----LYSALQQALGSVCESRPELSGGG-DSAPS-VWGLEPDQNGARSLFKRGPLLTA 1235
Query: 2960 LTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQRE---AEVYDS---- 3012
L+ + H + Q + R + + L++ +T + ++ E+ D
Sbjct: 1236 LSAEAVASAL-HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQL 1294
Query: 3013 SQSHESFSDWRGEL------LLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQ 3066
SQ+ E S W G+ L+ L + +S L A + A G + LL ++
Sbjct: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE---LLQAAKE 1351
Query: 3067 RIQEQGVEYQAAM-ECLQKADRRSLLSE-IQALHAQMNGRKITLKREQESEKPSQELLEY 3124
+ Q QAA+ E +A +L E ++ + + + ++ E+E + QE E
Sbjct: 1352 NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGEL 1411
Query: 3125 NIQQKQS----------QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE 3174
+ Q ++ + E + E+ +++ + EL++Q +K + L +L + E
Sbjct: 1412 KVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQE 1471
Query: 3175 LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQW-------ALEKE 3227
++ Q + ++ELE R ++ V L ++++ REL+ LE +
Sbjct: 1472 VDL----QQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ 1527
Query: 3228 KAKLGRSE---ERDKEELEDLKFSLESQKQRNLQL---NLLLEQQKQLLNESQQKIESQR 3281
+L + + E + +++DLK L + + L+L + +E Q++L+ E + + E+QR
Sbjct: 1528 LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR 1587
Query: 3282 MLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL------DRERELHAQLQSSDGTGQS 3335
+ + + R+ ELQ +S ++ E ST+ +R++E+ +Q + + +
Sbjct: 1588 VALTHLTLDLEERSQELQA--QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQ 1645
Query: 3336 RPPLPSE--------DLLKELQKQLEEKHSRIVELLNET-EKYKLDSLQTRQQMEKDRQV 3386
+ L + L KE + LE++ +R ++L E E+ KL + +++ RQ+
Sbjct: 1646 KEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQL 1705
Query: 3387 --------------------HRKTLQTEQEANTEGQKK-MHELQSKVEDLQRQLEEKRQQ 3425
H K + ++E E Q++ +HELQ + L++QL+ ++
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765
Query: 3426 VYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3484
V + L QR Q I+ Q+ + RE+ + L L+E D+ + Q+
Sbjct: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825
Query: 3485 KIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADD 3544
+ + + +E + + G LE L+ +LQ ++A RL+ E A +
Sbjct: 1826 QQQAQGQEERVKEKADALQGA------LEQAHMTLKERHGELQDHKEQA-RRLEEELAVE 1878
Query: 3545 EDFIWVQENI-----------DEIILQLQKLTGQQGEE 3571
+ E + ++ +L LQ+ +Q +E
Sbjct: 1879 GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Score = 145 bits (366), Expect = 8e-34
Identities = 280/1392 (20%), Positives = 590/1392 (42%), Gaps = 194/1392 (13%)
Query: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
E E E + Q E+ + LE ++ +Q E EA QR+ TQ + L Q
Sbjct: 860 EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
Query: 218 RREKDETMREFL--------ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQ 269
+ E ++ L EL + SQ+L+ Q ++ + T L +A+++
Sbjct: 920 QLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE 979
Query: 270 I----LTHQQQL----EEQDHLLE---DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVEN 318
+ H+ L EE LL+ D QK+ ED Q+ + ++ E E +K+
Sbjct: 980 LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
Query: 319 SNKEEIQEKETIIEE--LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376
+ + +KE E+ L ++E+E++ L L++ + + L L++ + + E K +
Sbjct: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099
Query: 377 --KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI---------VQRMEQE 425
++EL + KE++ ++ + Q +EEL+ + + Q + +Q +
Sbjct: 1100 SAQMELLRQEVKEKE-ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158
Query: 426 TQRKLEQLRAEL---DEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 482
T+ +LE L AE ++ Q + ++Q + + E + G ++A +
Sbjct: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG--- 1215
Query: 483 VNEDQ-----------------IKLMNVAINELNIKLQDT-------NSQKEKLKEELGL 518
+ DQ + + A+++L+ L T Q +KL+E L
Sbjct: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275
Query: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED-LKAEIVS 577
EK + +L+DL +LS ++E+ + ES+L E H+++++++ L+ +
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335
Query: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ-----EAELERLRTQLLFS 632
E++ E EL A+ N ++E L+ AV++ A++ E +L R+ L
Sbjct: 1336 RMEAQGERELLQAAK-ENLTAQVEHLQA---AVVEARAQASAAGILEEDLRTARSALKLK 1391
Query: 633 HEEELSKLKEDLEIEHRINI-----EKLKDNLGI------HYKQQIDGLQNEMSQKIETM 681
+EE S+ + ++ + + + L++NL + +++++ L+ ++ + +
Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451
Query: 682 QFEKDNL-------------ITKQNQLILEISKLKDLQQSL---VNSKSEEMTLQINELQ 725
+ +K L + Q + I E+ K + + + L V + +++T+Q +++
Sbjct: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511
Query: 726 KEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-------------DLQEKFAQ 772
E+ + E ++ LE ++ EL+ K +++E Q + ++ +L+E +
Sbjct: 1512 ---ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
Query: 773 LEAENSILK--DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830
+E + ++K + ++ + + H + EER L + S+ D E +L E +
Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD--LESHSTVLARELQ 1626
Query: 831 DLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE--LQEEYACLLKVKDDLEDSKNKQELE 888
+ Q+ E+IE+ + ++ E QE LQ+E +L+ + + +++LE
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Query: 889 -YKSKLKALNEELHLQR--------INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939
K L+ EL QR K + + K + + + E ++
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
Query: 940 ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEI 999
EL E + +++ L +++ + S L Q+ EI L ++ L++ +EQ L+ + L+
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ---LQEAREQGELKEQSLQ- 1802
Query: 1000 IINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENM 1059
++ + Q Q L+ + + A+G +V +E ++ + +M
Sbjct: 1803 ----SQLDEAQRALAQRDQELE-ALQQEQQQAQGQEERV-----KEKADALQGALEQAHM 1852
Query: 1060 TVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC 1119
T+ E + Q DH KE + R + E + + L+ DLR + Q
Sbjct: 1853 TLKERHGELQ---DH-----KEQARRLEE--ELAVEGRRVQALEEVLGDLRAESREQEKA 1902
Query: 1120 LSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ---EEKIKELQKIHQLELQTMKTQE 1176
L + +Q +E+ + +L++ + AQ +E+ +EL+ + + E Q+ + QE
Sbjct: 1903 LLALQQQCAEQAQEHEVETR-----ALQDSWLQAQAVLKERDQELEAL-RAESQSSRHQE 1956
Query: 1177 TGDEGK--PLHLLIGKLQKAVSEECSYFL-QTLCSVLGEYYTPALKCEVNA-EDKENSGD 1232
+ L +GK A+ + + L Q S E T L+ ++A + +
Sbjct: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE 2016
Query: 1233 YISENEDPELQD----YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGM 1288
++ E+QD Y+ +VQ Q+ + ++ + + +L+ L++ +
Sbjct: 2017 EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE 2076
Query: 1289 KLEFGEE------------------NLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSL 1328
K G+E L ++E E L + Q NLE + +HK+
Sbjct: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136
Query: 1329 QDLEKTKLEEQVQ-ELESLISSLQQ-QLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPV 1386
Q L+ LE ++Q ELE L ++L+Q + +E E +A+ L S S++
Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
Query: 1387 DSVVITESDAQR 1398
+ E D+++
Sbjct: 2197 LQASVLERDSEQ 2208
Score = 139 bits (349), Expect = 7e-32
Identities = 182/914 (19%), Positives = 400/914 (43%), Gaps = 91/914 (9%)
Query: 126 RTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTY 185
+T + ++LR++ +++ ++ A+ S H E+ + + +L++ EE
Sbjct: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQ--------RQLSQNQEEKSKWE 1305
Query: 186 GTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQL 245
G + E+ + + + L + L++A ++ E E L + L Q + L
Sbjct: 1306 GKQ-----NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHL 1360
Query: 246 QASETLRNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
QA+ + S+ DL A+ + +++E + + Q++ E Q LQ
Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
Query: 303 EKIKVYEM---EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359
E + + E++++VE + + +IQE E E + E +L+LK + D
Sbjct: 1421 ENLALLTQTLAEREEEVE-TLRGQIQELEKQREMQKAAL---ELLSLDLKKRNQEVDLQQ 1476
Query: 360 GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419
++QE + + ++++ + + +QK E+I++L KD + + +++
Sbjct: 1477 EQIQE-LEKCRSVLEHLPMAVQEREQKLTVQREQIREL-----------EKDRETQRNVL 1524
Query: 420 QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYS 479
+ E ++K + + ++ Q+ +K++L+ +E + HK E + L
Sbjct: 1525 EHQLLELEKKDQMIESQRG-----QVQDLKKQLVTLECLALELEENHHKMECQQKL---- 1575
Query: 480 NITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSF 539
I E Q + VA+ L + L++ + + + ++ + L R+L++ +E+
Sbjct: 1576 -IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634
Query: 540 SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599
REQI+ ++ L + L ++ + +++ +R+ L+ + E +IK
Sbjct: 1635 QREQIEELQRQKEHLTQDLERRDQELMLQKE-RIQVLEDQRTRQTKILEEDLE----QIK 1689
Query: 600 LEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE------IEHRINIE 653
L + E+ + R + AE + ++ E + + D E EH ++
Sbjct: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749
Query: 654 KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
+LKD L +QQ+ GL ++ + + + ++ Q QL E + +L++ + S+
Sbjct: 1750 ELKDQL----EQQLQGLHRKVGETSLLLSQREQEIVVLQQQL-QEAREQGELKEQSLQSQ 1804
Query: 714 SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE----LQLKTELLEKQMKEKENDLQ-- 767
+E + + +E+E L+QE+++ E+ V+E LQ E +KE+ +LQ
Sbjct: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864
Query: 768 -EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI 826
E+ +LE E ++ + LE++L S+E+ L +++ + + E E+E
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL-ALQQQCAEQAQEHEVETRA 1923
Query: 827 EENEDLKQQCI---------QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL-KVKD 876
++ L+ Q + L E + R+ A E + L + +A L K +
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983
Query: 877 DLEDSKNKQELEYK-SKLKALNE--ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV 933
LE ++ + LE + L+A + + H +++ + + D+D + + ++ +
Sbjct: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043
Query: 934 VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG------EISFLNEEVKSLK--- 984
+ + EL + E + + L+QR+ + Q KQ G EI L++ V+ L+
Sbjct: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103
Query: 985 QEKEQVSLRCRELE 998
+KEQ L RE +
Sbjct: 2104 AQKEQEILELRETQ 2117
Score = 61.2 bits (147), Expect = 2e-08
Identities = 129/644 (20%), Positives = 261/644 (40%), Gaps = 70/644 (10%)
Query: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63
+E Q+ L +L +Q + Q+ GQ K+K + + AH L +
Sbjct: 1806 DEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE---QAHMTLKERHGELQ 1862
Query: 64 EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
+ + ++R+E + E ++ L E+ + S E E + C+ +
Sbjct: 1863 D-HKEQARRLEEELAVEGRRVQALE--EVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
Query: 124 VMRTGKPTNLLREEEFGVDDSYSEQGA--QDSPTHLEMMESELAGKQHEIEELNRELEEM 181
R + DS+ + A ++ LE + +E +H+ E E +
Sbjct: 1920 ETR-------------ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEAL 1966
Query: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
+ G + LQ E + ++ + L A+ + D +L E L+IQ
Sbjct: 1967 QEALG-KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQ 2022
Query: 242 FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFL 301
++Q + LR L + + L HQQ E++ LLE ++ +Q + +
Sbjct: 2023 EGEIQ-DQDLRYQEDVQQLQQALAQRDEELRHQQ---EREQLLEKSLAQR----VQENMI 2074
Query: 302 QEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361
QEK + Q+++ +EEI+ + EL + ++E++ LEL++ T L
Sbjct: 2075 QEK---QNLGQERE-----EEEIRGLHQSVRELQLTLAQKEQEILELRE--TQQRNNLEA 2124
Query: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421
L E +++KL+ E + E+++L + + + R + + D+
Sbjct: 2125 LPHSHKTSPMEEQSLKLD-----SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179
Query: 422 MEQETQRKLEQLR--------AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMEN 473
+ Q T+ + L+ + L+ QQ +Q + EL R+ +E+ + G
Sbjct: 2180 LAQ-TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR---ALEKERLHSPGATST 2235
Query: 474 A-LRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR---Q 529
A L S V ++ + + ++ Q + E L++ + + ++ LQR Q
Sbjct: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295
Query: 530 LEDLVEELSFSREQIQRARQTIAEQES-KLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
L +E++ R +++R A+ S ++++A S T +D + + S ++ EL
Sbjct: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAEL--- 2352
Query: 589 HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS 632
+ EV + +L + K+K + R A++ EL L L S
Sbjct: 2353 -QKEVVLLQAQLTLERKQKQDYITRSAQTSR-ELAGLHHSLSHS 2394
Score = 59.7 bits (143), Expect = 6e-08
Identities = 137/677 (20%), Positives = 273/677 (40%), Gaps = 93/677 (13%)
Query: 3082 LQKAD--RRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
++KAD ++L +++ L + + L R++ + QE + ++ + ++L + E
Sbjct: 124 MEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWRE 183
Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET-----TLKAQHKHLKELEAFRL 3194
+ + + E++ + M ELK+E + L T T+ AQ + + R+
Sbjct: 184 VVTFRRHFLEMKSATDRDLM---ELKAEHVRLSGSLLTCCLRLTVGAQSREPNG--SGRM 238
Query: 3195 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3254
+ ++ + LL T E++ Q E +L + +K EL+D L +
Sbjct: 239 DGREPAQLLLLLAKTQELEKEAHERSQ-----ELIQLKSQGDLEKAELQDRVTELSALLT 293
Query: 3255 RNLQLNLLLEQQKQLLNESQQKIESQR---MLYDAQLSEE-QGRNLELQ-VLLESEKVRI 3309
++ + N E+ + L E+ + +E+ M ++A LS Q L LQ V+ + +V +
Sbjct: 294 QSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMV 353
Query: 3310 RE---------MSSTLDRERELHAQLQSSDG----TGQSRPPLPSEDLLKELQKQLEEKH 3356
E ++L+ + + +Q D T +++L++QL
Sbjct: 354 EEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ 413
Query: 3357 SRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQ 3416
+ L + ++++ + RQ+++K R TL + + Q ++ L + E LQ
Sbjct: 414 EAVNLLQQQHDQWEEEGKALRQRLQK-LTGERDTLAGQ---TVDLQGEVDSLSKERELLQ 469
Query: 3417 RQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ-ELEREEKRESRRILYQNLNEPTTWSLTSD 3475
+ EE RQQ+ L+ E RL+ + E Q Q + + +K E + L+ + E
Sbjct: 470 KAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE--------- 520
Query: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3535
R R + +E + ES ++LI + + E E++RQ+ V + L Q +E
Sbjct: 521 RERLQEMLMGLEAKQSES-LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579
Query: 3536 ------RLQFETAD-----------DEDFIWVQENIDEIILQLQK--------------- 3563
L+ E AD +E + +++ +LQL++
Sbjct: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639
Query: 3564 -------LTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3616
L + +L +T + ++ AEL + + EEK +++ KL
Sbjct: 640 RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQK---KL 696
Query: 3617 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKL 3676
E R ++ + + A EKE REK L+ L+ E + L
Sbjct: 697 SES-RHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 3677 KAELRNDSLLQTLSPDS 3693
+L+ S + L S
Sbjct: 756 AEQLQGLSSAKELLESS 772
Score = 51.6 bits (122), Expect = 2e-05
Identities = 128/681 (18%), Positives = 271/681 (39%), Gaps = 130/681 (19%)
Query: 3119 QELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKL---EL 3175
Q +LE + Q QM E Q + E Q++ ++ +V +L++++ Q + EL
Sbjct: 17 QLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQAT---LVRKLQAKVLQYRSWCQEL 73
Query: 3176 ETTLKA------------QHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3223
E L+A + +L EL E + + + + +N L +K+ + A
Sbjct: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
Query: 3224 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3283
L ++ KL R ++EL ++ + Q ++ L + +LL+ ++ + +R
Sbjct: 134 LREDVEKLTVDWSRARDEL--MRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191
Query: 3284 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3343
+ + + + R+L + L++E VR+ T + AQ + +G+G+ P++
Sbjct: 192 LEMKSATD--RDL---MELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQL 246
Query: 3344 LL-----KELQKQLEEKHSRIVELLNETEKYK---------LDSLQTRQQMEKD------ 3383
LL +EL+K+ E+ +++L ++ + K L +L T+ Q + +
Sbjct: 247 LLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMI 306
Query: 3384 ----------RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEG 3433
H + ++ E + Q++ LQ ++D+ + + E+ + +
Sbjct: 307 KALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366
Query: 3434 QRLQ---GIMQEFQKQELERE---------EKRESRRILYQNL-----------NEPTTW 3470
L+ I +F Q+ ++ +R++ + L Q L + W
Sbjct: 367 NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQW 426
Query: 3471 SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLP 3530
R + QK+ GE +++ + +++ G + E E++++ + + +L+VL
Sbjct: 427 EEEGKALRQRL--QKLTGE-RDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483
Query: 3531 QKA---------------SERLQFETADDEDFIWVQEN--IDEIILQLQKLTGQQGEEPS 3573
Q+A S + Q E +E + V+E + E+++ L+ + E
Sbjct: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI 543
Query: 3574 LVSPSTSCGSLTERLLRQN---------------AELTGHISQLTEEKNDLRNMVMKLEE 3618
+ + L LLRQ AEL+ + L E DLR +KL
Sbjct: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
Query: 3619 -----------------QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLT 3661
Q+ Q+ R ++ + N A +E +
Sbjct: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663
Query: 3662 LQKSLKRAEAEVYKLKAELRN 3682
L+ L++AE +L+A+LR+
Sbjct: 664 LEAQLQKAEEAGAELQADLRD 684
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 199 bits (507), Expect = 3e-50
Identities = 402/1998 (20%), Positives = 816/1998 (40%), Gaps = 259/1998 (12%)
Query: 215 QQARREKDETMREFLELTEQSQKLQI--QFQQLQASETLRNSTHSSTAADLLQAKQQILT 272
Q+ R+++ E RE E EQS+K + Q + + E L + +A+++ L
Sbjct: 135 QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 273 HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIE 332
+ E ++ E+ +++E ++ +EK + QD+ + ++E +++ET++
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254
Query: 333 ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
+ K+ EEE + ELQE+ + Q K + EL +Q+E Q +
Sbjct: 255 KEEEKLQEEEPQRQR-------------ELQEE---EEQLRKLERQELRRERQEEEQQQQ 298
Query: 393 EIK--QLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450
++ Q + +E ++R ++ + E +R EQ+ +R+ +QLR E +E QQ+ + ++
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQ--ERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 451 ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE 510
E R+ + E+ + R + ++ E Q++ E ++ + +++
Sbjct: 357 EERREQQLRREQEEERREQQLRR-----------EQQLRREQQLRREQQLRREQQLRREQ 405
Query: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED 570
+L+ E L E++ ++QL EE ++ Q R+ ++E + E L E+
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE--ERRDWLKREEE 463
Query: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLL 630
+ + R++ +LK + E + L++ E+E+ +R + E E R Q L
Sbjct: 464 TERH----EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519
Query: 631 FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEM-SQKIETMQFEKDNLI 689
EEE +L++ L E ++ E+ + + +++ L+ E Q+++ Q E+ + +
Sbjct: 520 KRQEEE-ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQ 749
K+ + + QQ L + E + ++ ++E+E L QEE+ + L++E E +
Sbjct: 579 LKREE--------ERRQQRLKREQEERLEQRLK--REEVERLEQEERREQRLKREEPEEE 628
Query: 750 LKTELLEKQMKEKENDLQEKFAQLEAENSILK--DEKKTLEDMLKIH-------TPVSQE 800
+ +LL+ + +E+ Q + Q E LK +E++ LE LK +++E
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Query: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEENE----DLKQQCIQLNEEIEKQRNTFSFAEKN 856
E+ + IKS+ W+ E E +++ KQ+ + +E E++R +
Sbjct: 689 EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR-----RRE 743
Query: 857 FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSV 916
E+ +QE + + + E+ + +++++ K+ L P + + +
Sbjct: 744 SELQWQEEERAHR-----QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL 798
Query: 917 FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFL 976
E++ +++ L E+ E +R + Q +++ E+ FL
Sbjct: 799 RAEERQ------------QREQRFLPEEEEKEQRRR------------QRREREKELQFL 834
Query: 977 NEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVS 1036
EE + ++E+ Q L+ E + + R + + Q R +
Sbjct: 835 EEEEQLQRRERAQ-QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 1037 KVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQ 1096
+ + +E +++ E++ + + +QEQ Q E ++LQ
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ----------------ERQYREEEQLQ 937
Query: 1097 KELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEE 1156
+E L E+ + R + E +R + KDK L +E+L+ + E
Sbjct: 938 QEEEQLLREEREKRRRQERER------------------QYRKDKKLQQKEEQLLGEEPE 979
Query: 1157 KIK--ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYY 1214
K + E +K ++ E + + +E LL + +K +E +
Sbjct: 980 KRRRQEREKKYREEEELQQEEE--------QLLREEREKRRRQEWERQYRK--------- 1022
Query: 1215 TPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKL-LVL 1273
K E+ E+++ + + E + E ++ Q+ LL + E + L
Sbjct: 1023 ----KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 1274 QTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK 1333
Q R + Q+ + + E E+ +E ++ E+ + + + Q+LE+
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Query: 1334 TKLEEQV--QELESLISSLQQQLK--ETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSV 1389
EE+ QE E L+ ++ + E E+ Y E Q+ Q + E +
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198
Query: 1390 VITESDAQRTM----YPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVA 1445
E + QR Y + ++ E E V++ K E + QLE+
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL 1258
Query: 1446 KVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFET 1505
+ S Q +L + G ++ ++ Q+++H+ E +L +++ + +
Sbjct: 1259 RDRQS-------QQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ--KEAKR 1309
Query: 1506 VDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSI 1565
D K +EE + L +E E + + D E++ + + +R+
Sbjct: 1310 RDRKSQEEKQLLREEREEKRRR------------QETDRKFREEEQLLQEREEQPLRRQE 1357
Query: 1566 HD----EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQRE 1621
D E + + R+ + E++L RQE R++ + +Q LR Q RQ
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLR--RQERERKFLKEEQQ---LRCQEREQQLRQDR 1412
Query: 1622 DQEQLQEEIKRLNRQLAQRSSIDNENLV--SERERVLLEELEALKQ---LSLAGREKLCC 1676
D++ +EE ++L+RQ R + E V ERER LEE + L+Q E+L
Sbjct: 1413 DRK-FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471
Query: 1677 ELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANN-----RL 1731
E Q + E EEQ + +E DRK + ER L++ R
Sbjct: 1472 EREEQQLHRQERDRKFLE-EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530
Query: 1732 LKILLEVVKTTAAVEETIGRHVLGIL---DRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788
K L E E+ + R G DR K + L R E E S +
Sbjct: 1531 RKFLQE--------EQQLRRQERGQQRRQDRDRKFREEEQL--RQEREEQQLSRQERDRK 1580
Query: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848
+E + + + E +L Q R ++ E EE L+
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
R + +E+ QL + Q +L + R+ +E + L+ EE + R E R
Sbjct: 1641 RDRKFLEE--------EPQLRRQEREQ-QLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 1909 AREQLAVELSKAEGVIDGYADEKTL----FERQIQEKTDIIDRLEQELLCASNRLQEL-- 1962
+ +L + E +E+ L ER+ +E+ + EQE L R +++
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751
Query: 1963 ------EAEQQQIQ-EERELLSRQKEAMKAEAGPVEQQL--------LQETEKLMKEKLE 2007
E E+QQ++ +ER+ R++E ++ E EQQL +E E+L +E+ E
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQERE--EQQLRSQESDRKFREEEQLRQEREE 1809
Query: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRK 2067
Q + ++ + + + L+++ +EQ L QE++ + +Q EK + ++
Sbjct: 1810 QQLRPQQRDGKYRWEEEQLQLEEQEQ-----RLRQERDRQYR-AEEQFATQEKSRREEQE 1863
Query: 2068 FLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
E+ R ER+ +E + + +Q K R + + E +++E + L+ T + +
Sbjct: 1864 LWQEEEQKRRQERERKLRE-EHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFAS 1922
Query: 2128 LLLSKEQLQRDIQERNEE 2145
+ + L IQE+ +
Sbjct: 1923 VPVRSSPLYEYIQEQRSQ 1940
Score = 193 bits (491), Expect = 2e-48
Identities = 422/1998 (21%), Positives = 793/1998 (39%), Gaps = 225/1998 (11%)
Query: 1567 DEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER--QREDQE 1624
DE + D L+ + Q ED R+ R Q ++ + RQ Q + E+Q
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 1625 QLQEEIKRLNRQLAQRSSIDNENLVSERE--RVLLEELEALK---------QLSLAGREK 1673
+ QE +++ +RQ ERE R E+L++ K + L RE
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 1674 LCCELRNSSTQTQNGNENQGEV----EEQTFKEKE-LDRKPEDVPPEILSNERYALQKAN 1728
L + + Q E Q V EE+ ++++E + RK E+ E + LQ+
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 1729 NRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788
+L K+ + ++ EE + L R + + R + E + E
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQR----LRREQQLRRKQEEERREQQEERREQQERREQQ 331
Query: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848
E R + + + EE E Q+L R E + E E L
Sbjct: 332 EERREQ--QLRREQEERREQQLRREQEEERRE--QQLRR------EQEEERREQQLRREQ 381
Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
+L+ + E QL + + E + R++Q+ + + E E HE+
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRRE---QQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
+E+ L + + + + ER QE+ + +QE L+ E E+++
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI 2028
QE R EQQL +E E+ +++L+ Q + E+++ L+ + + L
Sbjct: 499 QQERR-----------------EQQLRREQEERREQRLKRQEEEERLQQRLRSE-QQLRR 540
Query: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQ 2088
+ EE+ + ++ E+EK ++ ++ Q L+++ E+ R L ++ +R +R +QE +
Sbjct: 541 EQEERREQLLKREEEKR---LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE-E 596
Query: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE-------QLQRDIQE 2141
+LEQ+LK R + Q EQ + + ++ +LL S+E QL+R+ QE
Sbjct: 597 RLEQRLK---REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653
Query: 2142 RNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEV---QLQAERDAI 2198
R E+ K E LEQ L + ++ ++ +A+ + + Q Q E +A
Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 2199 DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDM 2258
R+ K + +Q Q R + + E+ ++ +L+ Q++E R Q+ E++ + F
Sbjct: 714 ARQSKVYSRPRKQEGQRRR--QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771
Query: 2259 EKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIE 2318
+ + + +S + + +++E ++ Q Q++ + + + E
Sbjct: 772 QAEEKSERGRQRLSAR---------PPLREQRERQLRAEERQ----QREQRFLPEEEEKE 818
Query: 2319 EKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN-AHSL 2377
++ R+ E +++ L +++ +R R +++++ + +++ Q+ + Q+ L
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 2378 SEEADSLKHQL--DVVIAEKLALEQQV------ETANEEMTFMKNVLKETNFK-MNQLTQ 2428
EE +H L + E+L EQQ+ E EE + +E ++ QL Q
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2488
E L RE + Q E D + K E + + + E + ++ EE
Sbjct: 939 EEEQLLREEREKRRRQ---ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE 995
Query: 2489 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
+ E L E + E + Y++ ++Q+ E E L ++ +++ E
Sbjct: 996 ------LQQEEEQLLREEREKRRRQEWERQYRKKDELQQ----EEEQLLREEREKRRLQE 1045
Query: 2549 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL-NQLREDELGSDISALTLR 2607
+ ++Q E + Q + E E Q L Q R++E
Sbjct: 1046 RERQYREEEELQQE----------EEQLLGEERETRRRQELERQYRKEE----------E 1085
Query: 2608 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL-EGNEKKQREKEKKRSP 2666
+ + E Q++ EK + + E+ E+E+ E ++LL E EK++R++ +++
Sbjct: 1086 LQQEEEQLLREEP----EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 2667 QDVEVLKTTTELFHSNEESGFFNELE-ALRAESVATKAELASYKEKAEKLQE--ELLVKE 2723
++ EV + +L E ELE R E + E +E+ EK ++ E +E
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201
Query: 2724 TNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTD 2783
QK + RD + K E E E V+++K C + ++ D
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQ-WEPEKENAVRDNKVYCKG-----RENEQFRQLED 1255
Query: 2784 GTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDME 2843
L+ S Q Q L+ G Q E + F E E+ E +
Sbjct: 1256 SQLRDRQSQQDLQHLL---GEQQERDREQERRRWQQRDRHFPE--EEQLEREEQKEAKRR 1310
Query: 2844 SRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSS 2903
R E + L RE + +E + Q L+ +E + ++ E+
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Query: 2904 DSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTES 2963
+ G +L Q R +E E F K+ + LR E Q+ +
Sbjct: 1371 EQGRK-----FLEEEQRL------RRQERER---KFLKE-EQQLRCQERE-QQLRQDRDR 1414
Query: 2964 PYSDGEDH-SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDW 3022
+ + E S Q+ + EE + K L + QL++E + + E
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER--HRKFREEEQLLQE 1472
Query: 3023 RGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECL 3082
R E QQ+ +ER F E L + E R QE ++ + L
Sbjct: 1473 REE-----QQLHRQERD---RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 3083 QKADR-RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141
+ R R L E Q L Q G++ R+++ + Q E QQ Q + + L
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLE 1584
Query: 3142 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK------------AQHKHLKEL 3189
K R E + + ++ +L+ + Q +L E K Q H +E
Sbjct: 1585 EQKVRRQEQERKFMEDEQ---QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 3190 EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD---KEELEDL- 3245
+ LE + + +K RE + L++ + + R +ERD +EE + L
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR 1701
Query: 3246 ------KFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR-NLEL 3298
KF E Q+ R +L +++QL E++Q+ ++ Y L EEQ R E
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE 1761
Query: 3299 QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSR 3358
Q L E+ R L +ERE QL+S + + R E L +E ++Q R
Sbjct: 1762 QQLRRQERDRKFREEEQLRQERE-EQQLRSQESDRKFR---EEEQLRQEREEQQLRPQQR 1817
Query: 3359 IVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQ 3418
+ E E+ +L+ + R + E+DRQ + E++ T+ + + E ++L ++
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQERDRQ-----YRAEEQFATQEKSRREE-----QELWQE 1867
Query: 3419 LEEKRQQVYKLDLEGQRLQGIMQEFQKQ----ELEREEKRESRRILYQNLNEPTTWSLTS 3474
E+KR+Q + L + ++ +E Q+ E++ +E + R+L EP T S
Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLL-----EPGTHQFAS 1922
Query: 3475 DRTRNWVLQQKIEGETKE 3492
R+ L + I+ + +
Sbjct: 1923 VPVRSSPLYEYIQEQRSQ 1940
Score = 172 bits (436), Expect = 6e-42
Identities = 371/1845 (20%), Positives = 762/1845 (41%), Gaps = 222/1845 (12%)
Query: 167 KQHEIEEL-------NRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
K HE EE REL E+R E QQ +E + + Q + + R+
Sbjct: 197 KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE-KEWRKRETVLRK 255
Query: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQ---- 275
E+++ E + + Q+ + Q ++L+ E R L+ +QQ+ Q+
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 276 -QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Q EE+ E ++++E Q+ QE+ + ++ ++++ E ++ +E+E EE
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE---EER 372
Query: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQ---EQIVQKNQEIKNMKLELTNSKQKERQSS 391
+ + E++ L + +L +L E Q EQ +++ Q+++ + +L +Q R+
Sbjct: 373 REQQLRREQQ-LRREQQLRREQQLRREQQLRREQQLRREQQLRREQ-QLRREQQLRREQE 430
Query: 392 EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQ----ETQRKLEQLRAELDEMYGQQIVQ 447
EE + E ++R ++ + D ++R E+ E +R+ +QL+ + +E ++ ++
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 448 MKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
+++E R+ + E+ R + E R + E++ +L +E ++ +
Sbjct: 491 LEEEERREQQERREQQLRREQEE-----RREQRLKRQEEEERLQQRLRSEQQLRREQEER 545
Query: 508 QKEKLKEELGLILEE---KCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKS 564
+++ LK E LE+ + L+R+ E+ ++L RE+ +R ++ EQE +L + K
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQL-LKREEERRQQRLKREQEERLEQRLK- 603
Query: 565 LSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELER 624
R+E+E + E ++K E E+E+ L + E +E ++
Sbjct: 604 -----------------REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646
Query: 625 LRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFE 684
LR + E+ L + +E+ +E R+ E ++ +++ + + E Q E +
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEE------RREQELAEEEQEQARERI--- 697
Query: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE-----EKEKG 739
K + Q QL E D +QS V S+ + Q ++E + R+E ++E+
Sbjct: 698 KSRIPKWQWQLESE----ADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Query: 740 TLEQEVQELQLKTELLEKQMKEKENDLQEKFA-----------QLEAENSILKDEKKTLE 788
Q+ +E Q + + Q +EK +++ + QL AE ++++ E
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 789 DMLKIHTPVSQEER---LIFL---DSIKSKSKDSVWEKEIEILIEENEDLKQQ------- 835
+ K + ER L FL + ++ + + ++E + L E+ E + Q
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873
Query: 836 -CIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDS------KNKQELE 888
QL EE +++R+T +A+ + ++L++E L + +++L+ + +QE +
Sbjct: 874 WRWQLEEERKRRRHTL-YAKPALQ---EQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929
Query: 889 YKSKLKALNEE---LHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945
Y+ + + EE L +R + + + K E +GE EK + EK
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK- 988
Query: 946 EVTKREKLELSQRLSDL--SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH 1003
RE+ EL Q L E+ K++ E + L+QE+EQ+ RE +
Sbjct: 989 --KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046
Query: 1004 NRAENVQSCDTQVSSLLDGVVTMTSR--GAEGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061
R + Q L G T R E K + EE +++ E+
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106
Query: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLS 1121
+ ++E+ + + +E + + + ++E V + E+ LR + E +R
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR---- 1162
Query: 1122 LVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK---IKELQKIHQLELQTMK-TQET 1177
+ R+Y E E+ L +E+L+ ++EK +E Q + ELQ K Q
Sbjct: 1163 -----RQELERQYREEEE---LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 1178 GDEGKPLHL---LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKEN-SGDY 1233
DE + L + + AV + Y + L+ + +D ++ G+
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 1234 ISENEDPELQDYRYEVQDFQENMHTLLNKVTE--------EYNKLLVLQTRLSKIWGQQT 1285
+ + E + ++ + F E + E + K L+ + R K Q+T
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 1286 DGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELES 1345
D K E+ L + E + L + + ++ H+ + + E+ +L Q +E +
Sbjct: 1335 D-RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE-EEQRLRRQERERKF 1392
Query: 1346 LISSLQQQLKETEQNYEAE-IHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGS 1404
L Q + +E EQ + ++ Q +S + + + +R
Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452
Query: 1405 CVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRI 1464
+ + +F E + +E +L ++ + EE ++ ++ EL
Sbjct: 1453 QQLRQ-ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511
Query: 1465 SGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEH 1524
++ +Q H +Q + E +L + + G Q + D KF+EE ++L +
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE-----EQLRQE 1566
Query: 1525 GKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE 1584
+E LS + +D+ F + +E V + R+ M +E
Sbjct: 1567 REEQQLSRQE--------------------RDRKFRL-----EEQKVRRQEQERKFMEDE 1601
Query: 1585 EQL------EDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638
+QL + +RQE R+++E +Q LL++ +Q+ RQ D++ L+EE + ++
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQ---LLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658
Query: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ-TQNGNENQGEVEE 1697
Q+ D + E E++L E E +QL R++ + R Q + E + EE
Sbjct: 1659 QQLRHDRDRKFREEEQLLQEGEE--QQLRRQERDR---KFREEEQQLRRQERERKFLQEE 1713
Query: 1698 QTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGIL 1757
Q + +EL+RK + E+ L++ R KIL E E+ + R
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRR-QERYRKILEEEQLRPEREEQQLRRQ----- 1767
Query: 1758 DRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE 1817
+R K + L R E E ++ + S R + + + E+
Sbjct: 1768 ERDRKFREEEQL--RQERE---------------EQQLRSQESDRKFREEEQLRQEREEQ 1810
Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
QR + + ++ E +E RL+ ++ A + ++Q E ++ + E
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQE------QRLRQERDRQYRAEEQFATQ-EKSRREEQE 1863
Query: 1878 LMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEG 1922
L +E +++++ E +E +R + EE R R+ ++ + +G
Sbjct: 1864 LWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKG 1908
Score = 169 bits (429), Expect = 4e-41
Identities = 360/1767 (20%), Positives = 719/1767 (40%), Gaps = 187/1767 (10%)
Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609
E++ ++ + R+ +E + +QL +E+ +QE R+ QE ++ E R
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 1610 QAHM-RQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSL 1668
+ + R+ E +RE Q + ++E +R +QL + + RE+ L E + ++ L
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395
Query: 1669 AGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN 1728
++L + Q E Q E+Q +E++L R+ E+ E +++ ++
Sbjct: 396 RREQQL-------RREQQLRREQQLRREQQLRREQQLRREQEEERHE----QKHEQERRE 444
Query: 1729 NRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788
RL + E EET +R + + L E E + EE
Sbjct: 445 QRLKREQEERRDWLKREEET---------ERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Query: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848
R + K EE L QRL E + E+L+
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
+ + E + + + E ++ +++QE + + E ERL +E R
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
++L E + E E+ RQ Q + + +R EQ L R +E E +Q+
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRL----KREEEEERLEQR 671
Query: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA--------------EK 2014
++ E E R++E + E +++ K + +LE + A ++
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSRIPK-WQWQLESEADARQSKVYSRPRKQEGQR 730
Query: 2015 VRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAI 2074
R + +++ + E +++ Q +Q++ + D Q QA EK ++ +
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790
Query: 2075 DREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 2134
+ ER + +E Q+ EQ RF P E E EQ +E+ +K + L +EQ
Sbjct: 791 REQRERQLRAEERQQREQ------RFLPEEE----EKEQRRRQRRER-EKELQFLEEEEQ 839
Query: 2135 LQR-----DIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEV 2189
LQR +QE + +++ + R R EQ + E ++ + AKP L ++
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899
Query: 2190 Q-----LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2244
+ LQ E + + R+E+E +EQ Q+REE + + EE Q L + E K+ R
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE--KRRRQERE 957
Query: 2245 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2304
++ ++ KL + + + LG +E + Q++ + + ++ QE+E + + E+ +
Sbjct: 958 RQYRKDKKLQQKEEQLLG---EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 2305 QQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELA 2364
+ + + +++ +E+ +L+R +E KR +E Q E E+LQQE
Sbjct: 1015 EWERQYRKKDELQQEEEQLLR------------EEREKRRLQERERQYREE-EELQQEEE 1061
Query: 2365 NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424
+ L EE ++ + Q LE+Q E + +L+E K
Sbjct: 1062 QL----------LGEERETRRRQ---------ELERQYRKEEELQQEEEQLLREEPEKRR 1102
Query: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484
+ +RER+ E+ + E + + + + ELE E+ E + +
Sbjct: 1103 R-------QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 2485 SFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2544
EE K LE + + E ++ L + ++ + +E+ E E LQ++ Q
Sbjct: 1156 --EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ-KRKQ 1212
Query: 2545 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL--NQLREDELGSDIS 2602
+ +E + L + Q E +E A +DN+ E + L +QLR+ + D+
Sbjct: 1213 RYRDEDQRSDL--KWQWEPEKENA--VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ 1268
Query: 2603 AL----TLRISELESQVVEMHTSLILEKEQVEIAE-KNVLEKEKKLLELQKLL--EGNEK 2655
L R E E + + E+EQ+E E K +++K E ++LL E EK
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Query: 2656 KQREKEKKRSPQDVEVLKTTTEL-FHSNEESGFFNELEALRAESVATKAELASYKEKAEK 2714
++R++ ++ ++ ++L+ E E F E E LR + K + + ++
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE-EELRHQEQGRKFLEEEQRLRRQE 1387
Query: 2715 LQEELLVKETNMTSLQKD--LSQVRDH-LAEAKEKLSILE-----KEDETEVQESKKACM 2766
+ + L +E + +++ L Q RD E +++LS E +E+E +V+ ++
Sbjct: 1388 RERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447
Query: 2767 FEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS--EEVTEIISQF 2824
F +L + + + Q+L + Q++ Q EE ++ Q
Sbjct: 1448 FLEEEQQLRQE---------RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498
Query: 2825 TEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGS 2884
++ + QEL + E E + + E + L R+ + L+EE Q LR +E
Sbjct: 1499 RDRKFREQELRSQE---PERKFLEEEQQLHRQQRQR-KFLQEE--------QQLRRQERG 1546
Query: 2885 SIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG-RGEESESATDSFPKKI 2943
++ E + Q + F + + R +E E +++
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQ--QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604
Query: 2944 KGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQL 3003
+ EG Q L ++ +Q+ E L ++ K L + QL
Sbjct: 1605 R------RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE------RDRKFLEEEPQL 1652
Query: 3004 QREAEVYDSSQSHESFSDWRGELLLAL----QQVFLEERSVLLAAFRTELTALGTTDAVG 3059
+R+ + H+ +R E L QQ+ +ER FR E L +
Sbjct: 1653 RRQER--EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD---RKFREEEQQLRRQERER 1707
Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ 3119
EQ+++ Q +E + ++ ++ +E + L Q RKI + + E+ Q
Sbjct: 1708 KFLQEEQQLRRQELERK-----FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762
Query: 3120 ELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTL 3179
+L +K + +++ E + R+ E + E+ + E + + + + + +
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ-QRDGKY 1821
Query: 3180 KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDK 3239
+ + + L +LE ++ + D + + A+++K RE Q ++E+ K R +ER++
Sbjct: 1822 RWEEEQL-QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK--RRQERER 1878
Query: 3240 EELEDLKFSLESQKQRNLQLNLLLEQQ 3266
+ E+ + ++QR+ Q+ + Q+
Sbjct: 1879 KLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 169 bits (427), Expect = 6e-41
Identities = 393/1952 (20%), Positives = 803/1952 (41%), Gaps = 223/1952 (11%)
Query: 767 QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI 826
+EK A+ + + S+L+D ++ ED + Q E + + + E+E E+
Sbjct: 97 EEKRARCDGKESLLQDRRQE-EDQRRFEPRDRQLE-----EEPGQRRRQKRQEQERELAE 150
Query: 827 EENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQE 886
E + KQ+ + E+ ++QR + E +QE +E A ++ L+ K +
Sbjct: 151 GEEQSEKQERL---EQRDRQRRDEELWRQRQE--WQEREERRA----EEEQLQSCKGHET 201
Query: 887 LEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
E+ + + EL R K + +D+ F E E E +++T L ++ E
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE--EEKEWRKRETV-LRKEEE 258
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRA 1006
+ E+ + + L + EQL++ +E++ +QE+EQ R R + +
Sbjct: 259 KLQEEEPQRQRELQEEEEQLRKLE------RQELRRERQEEEQQQQRLRREQQLRRKQEE 312
Query: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
E + + + E + + E + E ++ E EE +
Sbjct: 313 ERREQQEERREQ---------QERREQQEERREQQLRREQEERREQQLRREQ----EEER 359
Query: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126
+EQ + +E LR Q +L++E + + +Q LR + + +R
Sbjct: 360 REQQLRREQEEERREQQLRREQ-----QLRREQQLRREQQ--LRREQQLRR--------- 403
Query: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
Q+R + +++ L +E+ + ++E+ + QK H+ E + + + +E +
Sbjct: 404 -EQQLRREQQLRREQQL--RREQQLRREQEEERHEQK-HEQERREQRLKREQEERRDWLK 459
Query: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
+ ++ E L+ L+ E E +E + E E ++ R
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL-RREQEERREQR 518
Query: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306
+ Q+ +E + L +E+ + + R + ++ ++ E E+ L +E+ E
Sbjct: 519 LKRQEEEERLQQRLR--SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER-- 574
Query: 1307 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIH 1366
Q+ E+ + K + LE+ E+V+ LE +Q+LK E E
Sbjct: 575 -RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE-ERREQRLKREEPEEERRQQ 632
Query: 1367 CLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEET 1426
L+ Q E L + E +R ++ ++ ++ E EE
Sbjct: 633 LLKSEEQ---EERRQQQLRREQQERREQRLKREEE-----EERLEQRLKREHE----EER 680
Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQH 1486
+L E++ QEQ E + I + + + K + KQ +QEQ
Sbjct: 681 REQELAEEE-QEQARERIKSRIPKWQWQLESEADARQ---SKVYSRPRKQEGQRRRQEQE 736
Query: 1487 YFNEMKLSQDQIGFQTFETVDVKFKEE-------FKPLSKELGEHGKEILLSNSDPHDIP 1539
+ + + ++ +Q E + +EE ++ ++E E G++ L + +
Sbjct: 737 --EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP---LR 791
Query: 1540 ESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQ 1599
E ++ L +EE +++ F+ + ++ + ++L EE+ + R+E +Q Q
Sbjct: 792 EQRERQLR-AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Query: 1600 EHQQATELLRQAHMRQMERQREDQE---QLQEEIKRLNRQLAQRSSIDNENLVSERERVL 1656
E + L R+ + QR DQ+ QL+EE KR L + ++ + +E+ L
Sbjct: 851 EEEDG--LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ---LRKEQQL 905
Query: 1657 LEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI 1716
L+E E ++L REK R + E + EEQ +E+ R+ ++ +
Sbjct: 906 LQEEE--EELQREEREK---RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 1717 LSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAE 1776
+++ LQ+ +LL EE R +R K + L + E E
Sbjct: 961 RKDKK--LQQKEEQLLG------------EEPEKRRRQ---EREKKYREEEEL--QQEEE 1001
Query: 1777 ASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEID 1836
++ E R E Y D + + + E L +R R E+
Sbjct: 1002 QLLRE---EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER-ERQYREEEELQ 1057
Query: 1837 PENEELM-LNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKC 1895
E E+L+ +R + +E+ E + E + E R R++Q E +
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ-CREEEEL 1116
Query: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
Q+E + L EE R + +E E E ++Q++ + + R E E
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYRE-------------EEEVQQEEEQLLREEPE---- 1159
Query: 1956 SNRLQELEA---EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA 2012
R QELE E++++Q+E E L R+++ + + ++ +E E+L ++K + + +
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQE---RERQYREEEELQRQKRKQRYRD 1216
Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIE-LEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
E R DL+ Q + + + + + E E+ +L D + +++ ++ L+ + ++
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG--EQ 1274
Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131
Q DRE ER +QQ R P E RE ++ A K+ + +LL
Sbjct: 1275 QERDREQERRRWQQR-----------DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE 1323
Query: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQL 2191
+ + +R QE + + + E ++E E+ L + +K + + + + L E +L
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL 1383
Query: 2192 QA-ERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2250
+ ER+ KE++ +E+ +Q R++ + K E +Q QL Q+++ R E+E
Sbjct: 1384 RRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ---QLSRQERDRKFR----EEE 1436
Query: 2251 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK-LQQQLK 2309
++ + + E+ L E + Q++H F + Q++QE+E + E+ K L+++ +
Sbjct: 1437 QQVRRQERERKFL---EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493
Query: 2310 ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQK 2369
+ + + + + +R E + + L +Q+ ++ R+ + Q + + + ++ GQ+
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER-----GQQ 1548
Query: 2370 TSMNAHSLSEEADSLKHQLDVVIAE------KLALEQQ-VETANEEMTFMKN-------- 2414
+ E + L+ + + K LE+Q V +E FM++
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608
Query: 2415 ----VLKETNFKMN---QLTQE-----LFSLKRERESVEKIQSIPENSVNVAIDHLSKDK 2462
+ +E + K QL QE L +R+R+ +E+ + + H +D+
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH-DRDR 1667
Query: 2463 P--ELEVVLTEDALKSLENQTYFKSF-EENGKGSIINLETRLLQLESTVSAKDLELT-QC 2518
E E +L E + L Q + F EE + E + LQ E + ++LE +
Sbjct: 1668 KFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE 1727
Query: 2519 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN--QT 2576
+Q++ EQ Q + +KI+ +++ E+ L Q + +E + Q+ Q
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ 1787
Query: 2577 ISSEPERTNIQNLNQLR----EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIA 2632
+ S+ + QLR E +L R E + Q+ E L E+++ A
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRA 1847
Query: 2633 EKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2664
E+ +EK E Q+L + E+K+R++ +++
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQKRRQERERK 1879
Score = 140 bits (354), Expect = 2e-32
Identities = 253/1275 (19%), Positives = 526/1275 (41%), Gaps = 180/1275 (14%)
Query: 15 AKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSK----HDVSAHHDLNIDQS--------QC 62
A+ ++ R + +GQ ++Q++KR+ S+ + AH ++ Q
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773
Query: 63 NEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCS 122
E QR+ + R L + E EQ F E E + E
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE-LQ 832
Query: 123 FV-----MRTGKPTNLLREEEFGVDDSYSEQGAQDS------------------------ 153
F+ ++ + L+EEE G+ + + +Q+
Sbjct: 833 FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Query: 154 PTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTAN 213
P E + E Q E EEL RE E R E +Q +E E ++ + ++ +
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE--RQYREEEQLQQEEEQLLRE---- 946
Query: 214 LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA-----DLLQAKQ 268
++ +R + E R++ + +KLQ + +QL E + +L Q ++
Sbjct: 947 -EREKRRRQERERQY----RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 269 QILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKE 328
Q+L +++ + Y+KK E + L+E+ + +++ ++ +E QE+E
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061
Query: 329 TII-EELNTKIIEE-----------------------EKKTLELKDKLTTADKLLGELQE 364
++ EE T+ +E EK+ + +++ ++ L + +E
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121
Query: 365 QIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF--ETDIVQRM 422
Q++++ +E K + EL ++E + +E +QL+ E ++R + Q+ E ++ Q
Sbjct: 1122 QLLREERE-KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180
Query: 423 EQETQRKLEQLRAELDEMY--GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS--- 477
EQ + + E+ R E + Y +++ + K++ + Q ++K + + E ENA+R
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240
Query: 478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL 537
Y NE +L + +L+D SQ++ L+ LG E +R+ +
Sbjct: 1241 YCKGRENEQFRQLE-------DSQLRDRQSQQD-LQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYK 597
EQ++R Q A++ + ++ K L R+E E K + T+ K
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQL---------------LREEREEKRRRQETDRK 1337
Query: 598 IKLE--MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEK- 654
+ E +L++ + L R ++ E LR H+E+ K E+ + R E+
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFREEELR------HQEQGRKFLEEEQRLRRQERERK 1391
Query: 655 -LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
LK+ + +++ L+ + +K E++ +++Q + K ++ +Q + +
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFR----EEEQQLSRQER----DRKFREEEQQVRRQE 1443
Query: 714 SEEMTLQINELQKEIEILRQEE----KEKGTLEQEVQELQLKTELLEKQMKEKENDLQ-- 767
E L+ E + LRQE +E+ L QE +E QL + +++ E+E L+
Sbjct: 1444 RERKFLE------EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Query: 768 ---EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824
KF + E + + E+K LE+ ++H Q + L ++ + + ++ +
Sbjct: 1498 ERDRKFREQELRSQ--EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Query: 825 LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884
E E L+Q+ + +++ +Q F + +V QE + ++ ++ + L + +
Sbjct: 1556 KFREEEQLRQE--REEQQLSRQERDRKFRLEEQKVRRQEQERKF---MEDEQQLRRQEGQ 1610
Query: 885 QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVE--------- 935
Q+L + K +E LQ + + + D+ F+ E ++
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQ----ERDRKFLEEEPQLRRQEREQQLRHDRD 1666
Query: 936 ---KDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSL 992
++ +L+++ E + + E ++ + +QL+++ E FL EE + +QE E+
Sbjct: 1667 RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER--- 1723
Query: 993 RCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052
+ RE E + E ++ + L + + + + ++ F EE ++ E
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783
Query: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQ 1112
+ E +ES ++ + L +E LR Q + K + E L+ E+ + RL+
Sbjct: 1784 E---EQQLRSQESDRKFREEEQLRQEREEQQLRPQQ--RDGKYRWEEEQLQLEEQEQRLR 1838
Query: 1113 MEAQR-ICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQT 1171
E R ++T RE E +++ +E +EE I+ QK Q Q
Sbjct: 1839 QERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898
Query: 1172 --MKTQETGDEGKPL 1184
+K+QE G+ L
Sbjct: 1899 GEIKSQEGKGHGRLL 1913
Score = 135 bits (341), Expect = 6e-31
Identities = 242/1224 (19%), Positives = 521/1224 (42%), Gaps = 161/1224 (13%)
Query: 2 EDEERQKKL---EAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNID 58
E+E RQ+ L E + + Q R+ + + Q ++++++R K + H + +
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE---HEEERRE 682
Query: 59 QSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEV 118
Q E + +R++S IP+ + +LESE AD S+V
Sbjct: 683 QELAEEEQEQARERIKSR-IPK------------------WQWQLESE----ADARQSKV 719
Query: 119 NGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNREL 178
R K R +E E+ + + L+ E E A +Q + EE R+
Sbjct: 720 -----YSRPRKQEGQRRRQE-------QEEKRRRRESELQWQEEERAHRQQQEEEQRRDF 767
Query: 179 --EEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREK---DETMREFLELTE 233
+ G Q+L +QR+ QL A +Q R ++ +E +E
Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRE---RQLRAEERQQREQRFLPEEEEKEQRRRQR 824
Query: 234 QSQKLQIQF----QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQD--HLLEDY 287
+ ++ ++QF +QLQ E + D LQ Q+ Q+Q +Q LE+
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEE---DGLQEDQERRRSQEQRRDQKWRWQLEEE 881
Query: 288 QKKKEDFTMQISFLQEKIK------------VYEMEQDKKVENSNKEEIQEKETIIEELN 335
+K++ LQE+++ + E++K+ + + +E+E + +E
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941
Query: 336 TKIIEE-EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEI 394
+ EE EK+ + +++ DK L + +EQ++ + E K + E ++E + +E
Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE-KRRRQEREKKYREEEELQQEE 1000
Query: 395 KQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIR 454
+QL+ E ++R + Q+ + E+E + E+ + L E Q ++E ++
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ---YREEEELQ 1057
Query: 455 QHMAQM--EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKL 512
Q Q+ EE +TR + E+E R + E+Q+ L++ ++ +
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL-------------LREEPEKRRRQ 1104
Query: 513 KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLK 572
+ E EE+ LQ++ E L+ E R + + RQ E+E + E + L+
Sbjct: 1105 ERERQCREEEE--LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE-------QLLR 1155
Query: 573 AEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS 632
E E + + E E+ + +L E+EK +E EL+R + + +
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 633 HEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQ 692
E++ S LK E E K+N K G +NE +++E Q +D +
Sbjct: 1216 DEDQRSDLKWQWEPE--------KENAVRDNKVYCKGRENEQFRQLEDSQL-RDRQSQQD 1266
Query: 693 NQLILEISKLKDLQQ----------------SLVNSKSEEMTLQINELQKEIEILRQEEK 736
Q +L + +D +Q L + +E + + Q+E ++LR+E +
Sbjct: 1267 LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326
Query: 737 EKGTLEQEVQELQLKTELLEKQMKE--KENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
EK ++ ++ + + +LL+++ ++ + + KF + E + + +K LE+ ++
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ--EQGRKFLEEEQRLR 1384
Query: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
QE FL K + + E+E ++ + + +++ +++ +Q F E
Sbjct: 1385 ---RQERERKFL---KEEQQLRCQEREQQLRQDRDRKFREE----EQQLSRQERDRKFRE 1434
Query: 855 KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE-ELHLQRINPTTVKMK 913
+ +V QE + ++ L+ + L ++++ E + L+ E +LH Q + ++ +
Sbjct: 1435 EEQQVRRQERERKF---LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491
Query: 914 SSV--FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQ----RLSDLSEQLK 967
+ + D+ F + L E E+ E ++L +R++ L + R + +Q +
Sbjct: 1492 QQLRRQERDRKFREQELRSQE-PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550
Query: 968 QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027
Q + F EE ++E++Q+S + R+ + + + V+ + + + D
Sbjct: 1551 QDR-DRKFREEEQLRQEREEQQLSRQERDRKFRLEE---QKVRRQEQERKFMEDEQQLRR 1606
Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT 1087
G + + ++ F E+ +++ E + E +E +++ L+ P + ++ +
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQERE---EQQLHRQE--RDRKFLEEEPQLRRQEREQQL 1661
Query: 1088 QPSENDKLQKELNVL-KSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
+ + K ++E +L + E+ LR Q ++ ++ R++++ E+ L
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721
Query: 1147 KEELIFAQEEKIKELQKIHQLELQ 1170
+ + F +EE++++ + QL Q
Sbjct: 1722 ERK--FREEEQLRQETEQEQLRRQ 1743
Score = 108 bits (271), Expect = 8e-23
Identities = 251/1261 (19%), Positives = 503/1261 (39%), Gaps = 161/1261 (12%)
Query: 2286 IIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVK 2342
++Q++ E DQ + +QL+ + +++ E R+L E Q E ++ +
Sbjct: 109 LLQDRRQEEDQ--RRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDR 166
Query: 2343 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE--EADSLKHQLDVVIAEKLALE- 2399
+ R+EE+ + + ++ ++ A Q S H E + + L+ + + + K E
Sbjct: 167 QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEK 226
Query: 2400 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK-IQSIPENSVNVAIDHL 2458
QQ ++ F + KE + L +E L+ E ++ +Q E + L
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 2459 SKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQC 2518
+++ E E + + Q + EE + + + E ++ +L +
Sbjct: 287 RRERQEEE----QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342
Query: 2519 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ--DNQT 2576
++ ++ Q + + E E ++++ Q+ EE+ L + QL Q+ + Q Q
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQE--EERREQQLRREQQLRREQQLRREQQLRREQQ 400
Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
+ E + Q L RE +L + LR + E + + H E+E+ E K
Sbjct: 401 LRREQQLRREQQLR--REQQLRREQQ---LRREQEEERHEQKH-----EQERREQRLKRE 450
Query: 2637 LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRA 2696
E+ + L+ ++ E +E+++R+++ KR Q+ E + +L + LR
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRD-QEEERRERWLKLEEEERREQQERREQQLRR 509
Query: 2697 ESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2756
E + + +E+ E+LQ+ L ++ Q+R E +E+L L++E+E
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQ-----------QLRREQEERREQL--LKREEEK 556
Query: 2757 EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEE 2816
+++ ++ +L + + D LK + ++ + + L+ EE
Sbjct: 557 RLEQERREQ-------RLKREQEERRDQLLKREEERRQQRLKREQ---EERLEQRLKREE 606
Query: 2817 VTEIISQFTE----KIEKMQELHAAEILDMESRHISETETLKREHYVA-VQLLKEECGTL 2871
V + + K E+ +E ++L E + + L+RE Q LK E
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Query: 2872 KAVIQCLRS-KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGE 2930
+ + R +E ELA + Q RE S W + E +
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK-WQWQL------------ESEAD 713
Query: 2931 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2990
+S S P+K +G R E + +E + + E QQ E E+R+
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE---EQRR----- 765
Query: 2991 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3050
D + Q + ++E RG L+ + E+R L A +
Sbjct: 766 -----DFTWQWQAEEKSE--------------RGRQRLSARPPLREQRERQLRAEERQQR 806
Query: 3051 ALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA----QMNGRKI 3106
EQR + E + ++ RR E+Q L Q R
Sbjct: 807 --------------EQRFLPEEEEKEQ-----RRRQRREREKELQFLEEEEQLQRRERAQ 847
Query: 3107 TLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRAT-----ELQEQLSSEKMVV 3161
L+ E++ + QE +Q++ Q Q+E + R T LQEQL E+ ++
Sbjct: 848 QLQEEEDGLQEDQERRRSQ-EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906
Query: 3162 AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQ 3221
E + EL + + E + + ++ +R E + + +E LL + +++ RE Q
Sbjct: 907 QEEEEELQREERE-------KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959
Query: 3222 WALEK-----EKAKLGRSEE-----------RDKEELEDLKFSL---ESQKQRNLQLNLL 3262
+ +K E+ LG E R++EEL+ + L E +K+R +
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019
Query: 3263 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3322
++ +L E +Q + +R Q E Q R E + L + E+ + E T R +EL
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYR--EEEELQQEEEQLLGEERET-RRRQEL 1076
Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEK 3382
Q + + Q L E+ K +++ E + EL E E+ + + R++ E
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 3383 DRQVHRK---TLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGI 3439
+RQ + + EQ E +K+ + + + +L+++ +Q+ + + E +R +
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196
Query: 3440 MQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLI 3499
Q +++EL+R+++++ R Q + W N V K+ + +E+ + +
Sbjct: 1197 RQYREEEELQRQKRKQRYRDEDQRSDLKWQW---EPEKENAVRDNKVYCKGRENEQFRQL 1253
Query: 3500 E 3500
E
Sbjct: 1254 E 1254
Score = 99.8 bits (247), Expect = 5e-20
Identities = 230/1155 (19%), Positives = 448/1155 (38%), Gaps = 199/1155 (17%)
Query: 2625 EKEQVEIAEKNVLEK--EKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSN 2682
E+EQ++ + + E+ +++ L ++LLE K + EK+++R + V + E
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248
Query: 2683 EESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAE 2742
E+ E E L+ E + EL +E+ KL+ + L +E Q+ + R+
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR-REQQLR 307
Query: 2743 AKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNA 2802
K++ E+++E Q+ ++ E +L + + + L+ + +
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ----- 362
Query: 2803 GIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ 2862
Q+ + E EE E + +++ + Q+L + L E + + + L+RE Q
Sbjct: 363 --QLRREQE---EERREQQLRREQQLRREQQLRREQQLRREQQ-LRREQQLRREQ----Q 412
Query: 2863 LLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFD 2922
L +E+ L+ Q R +E + + + R + DW +
Sbjct: 413 LRREQ--QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK----------- 459
Query: 2923 IASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV-LSLTESPYSDGEDHSIQQVSEPWL 2981
E E+ ++ + L R E + L L E + ++ QQ+
Sbjct: 460 -------REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 2982 EERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVL 3041
E R+ +L+R+ E Q S R E +Q+ E
Sbjct: 513 ERRE---------------QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE--- 554
Query: 3042 LAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM 3101
E+R++++ E + E ++ D Q L +
Sbjct: 555 -----------------------EKRLEQERREQRLKREQEERRD--------QLLKREE 583
Query: 3102 NGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV 3161
R+ LKREQE E LE +++++ + LE + R E E+ ++++
Sbjct: 584 ERRQQRLKREQE------ERLEQRLKREEVERLEQEERREQRLKR--EEPEEERRQQLLK 635
Query: 3162 AELKSELAQTKLELETTLKAQHKHLKELEAFRLE--VKDKTDEVHLLNDTLASEQKKSRE 3219
+E + E Q +L E + + + +E E RLE +K + +E + EQ+++RE
Sbjct: 636 SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695
Query: 3220 L--------QWALEKEK-AKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
QW LE E A+ + R +++ E Q++R Q ++K+
Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQ--------EGQRRRQEQ------EEKRRR 741
Query: 3271 NESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERE-LHAQLQSS 3329
ES+ + + + + Q EEQ R+ Q E + R R+ S RE QL++
Sbjct: 742 RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE 801
Query: 3330 DGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL-----------DSLQT-- 3376
+ + + LP E+ ++ ++Q E+ + + L E E+ + D LQ
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKEL-QFLEEEEQLQRRERAQQLQEEEDGLQEDQ 860
Query: 3377 --------------RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK 3422
R Q+E++R+ R TL + + +K+ LQ + E+LQR+ EK
Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK 920
Query: 3423 --RQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL----------YQNLNEPTTW 3470
RQ+ + E ++LQ ++ ++E E+ ++E R Q L E
Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 3471 SLTSDRTRNWVLQQKIEGETK---------------ESNYAKLIEMNGGGTGCNHELEMI 3515
+R + + +++++ E + E Y K E+ E +++
Sbjct: 981 RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ------QEEEQLL 1034
Query: 3516 RQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQE----NIDEIILQLQKLTGQQGEE 3571
R++ + K ++ ++ R + E +E+ + +E E+ Q +K Q EE
Sbjct: 1035 REERE----KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090
Query: 3572 PSLV--SPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAG 3629
L+ P ER R+ EL QL E+ + R +LE Q R +
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR-QELERQYREEEEVQQE 1149
Query: 3630 RDNSSRF--SLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAE---VYKLKAELRNDS 3684
+ R +E E+E+ E+ L++ ++ E Y+ + EL+
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQK 1209
Query: 3685 LLQTLSPDSEHVTLK 3699
Q + + LK
Sbjct: 1210 RKQRYRDEDQRSDLK 1224
Score = 93.2 bits (230), Expect = 5e-18
Identities = 135/573 (23%), Positives = 240/573 (41%), Gaps = 59/573 (10%)
Query: 3083 QKADRRSLLSEIQALHAQMNGRKITLKREQESE-------KPSQELLEYNIQQKQSQMLE 3135
Q+ D+R + L + R+ ++EQE E QE LE +Q++ + L
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW 174
Query: 3136 MQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTK----LELETTLKAQHKHLKELEA 3191
Q + ++ +EQL S K E + Q + LEL + + + +
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 3192 FRLEVKDKTDEVHLLNDTLASEQKK--------SRELQWALEKEKAKLGRSE---ERDKE 3240
R+ +++ E L E++K RELQ E++ KL R E ER +E
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ-EEEEQLRKLERQELRRERQEE 293
Query: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300
E + + E Q +R + +Q+++ E Q++ E Q + QL EQ E Q+
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEER--REQQERREQQEERREQQLRREQEERREQQL 351
Query: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3360
E E+ R + E QL+ + + + L +E Q + E++ R
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411
Query: 3361 ELLNETEKYKLDSLQTRQQMEKDRQVH-----RKTLQTEQE-----ANTEGQKKMHELQS 3410
+L E + + L+ Q+ E+ Q H + L+ EQE E + + HE +
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 3411 KVEDLQR-QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE-EKRESRRILYQNLNEPT 3468
+ + L+R Q EE+R++ KL+ E +R Q QE ++Q+L RE E+R +R+ Q E
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQ---QERREQQLRREQEERREQRLKRQEEEERL 528
Query: 3469 TWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKL--QCVASKL 3526
L S++ +++ E K K +E E E R +L + +
Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREE-EKRLEQERREQRLKREQEERRDQLLKREEERRQ 587
Query: 3527 QVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTE 3586
Q L ++ ERL+ +E E +++ + Q+L ++ EE +
Sbjct: 588 QRLKREQEERLEQRLKREE-----VERLEQEERREQRLKREEPEE-----------ERRQ 631
Query: 3587 RLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3619
+LL+ + QL E+ + R +K EE+
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEE 664
Score = 89.0 bits (219), Expect = 9e-17
Identities = 136/659 (20%), Positives = 263/659 (39%), Gaps = 97/659 (14%)
Query: 7 QKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMY 66
+++LE + K A+ R RK+Q + Q +++++KR+ + L
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL----------- 1344
Query: 67 INSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMR 126
Q E + R E+ EQG LE E + R
Sbjct: 1345 ---LQEREEQPLRRQERDRKFREEELRHQEQGRKF-LEEE---------------QRLRR 1385
Query: 127 TGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYG 186
+ L+EE+ +Q QD E +L+ ++ + + E + R
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 187 TEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE----LTEQSQKLQIQF 242
+ L++ Q+ ++ QL ++ + + E R+FLE L Q + + +
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505
Query: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Q+L++ E R Q +++ L +QQL Q+ + Q + F + Q
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362
E+ E +Q + E K ++E++ +E K +E+E++ + + +L E
Sbjct: 1566 ER----EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ----QQLRQER 1617
Query: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF--ETDIVQ 420
+ + Q ++ + + + ++++R+ EE QL E Q R+ +D +F E ++Q
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677
Query: 421 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
E++ R R E D + ++ Q++++ + Q E+ R E+E R
Sbjct: 1678 EGEEQQLR-----RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ--ELERKFR---- 1726
Query: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
E+Q++ Q+T ++ + +E ILEE+ QL EE
Sbjct: 1727 ---EEEQLR-------------QETEQEQLRRQERYRKILEEE-----QLRPEREEQQLR 1765
Query: 541 REQIQR-------ARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV 593
R++ R RQ EQ+ + E+ + E L+ E R+E +L+ +
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQE-------REEQQLRPQQRD 1818
Query: 594 TNYK-----IKLEMLEKEKNAVLDRM--AESQEAELERLRTQLLFSHEEELSKLKEDLE 645
Y+ ++LE E+ DR AE Q A E+ R + +EE K +++ E
Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE 1877
Score = 79.3 bits (194), Expect = 7e-14
Identities = 109/488 (22%), Positives = 217/488 (44%), Gaps = 81/488 (16%)
Query: 3065 EQRIQEQGVEYQAAMECLQKADRRSLL------SEIQALHAQMNGRKITLKREQESEKPS 3118
E+ +Q++ E Q E +K R+ L E+Q Q+ + +R QE E+
Sbjct: 1113 EEELQQE--EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170
Query: 3119 QELLEYNIQQKQSQML-EMQVELSSMKDRA----TELQEQLSSEKMVVAELKSELA-QTK 3172
+E E +QQ++ Q+L E Q + ++R ELQ Q ++ + +S+L Q +
Sbjct: 1171 RE--EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWE 1228
Query: 3173 LELETTLKAQHKHLK--ELEAFRL----EVKDKTDEVHLLNDTLASEQKKSRELQ---WA 3223
E E ++ + K E E FR +++D+ + L + L +Q++ RE + W
Sbjct: 1229 PEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH-LLGEQQERDREQERRRWQ 1287
Query: 3224 -----------LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNE 3272
LE+E+ K + +R +E + L +K+R + + +++QLL E
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347
Query: 3273 SQQ----KIESQRMLYDAQLS-EEQGRNL------------ELQVLLESEKVRIREMSST 3315
++ + E R + +L +EQGR E + L E +++R +E
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407
Query: 3316 LDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3375
L ++R+ + + + Q R E+ + +++ E K + L + K +
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467
Query: 3376 TRQQMEKDRQVH-----RKTLQTEQE-ANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKL 3429
Q +++Q+H RK L+ EQ+ E +K E + + ++ +R+ E+ QQ+++
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR- 1526
Query: 3430 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE 3489
QR + +QE +Q+L R+E+ + RR DR R + ++++ E
Sbjct: 1527 ---QQRQRKFLQE--EQQLRRQERGQQRR---------------QDRDRKFREEEQLRQE 1566
Query: 3490 TKESNYAK 3497
+E ++
Sbjct: 1567 REEQQLSR 1574
Score = 36.2 bits (82), Expect = 0.66
Identities = 68/312 (21%), Positives = 121/312 (38%), Gaps = 43/312 (13%)
Query: 3391 LQTEQEANTEGQ------KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQ 3444
L E+ A +G+ ++ E Q + E RQLEE+ GQR + QE +
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEE---------PGQRRRQKRQEQE 145
Query: 3445 KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGG 3504
++ E EE+ E + L Q + L R + W +++ E ++ K
Sbjct: 146 RELAEGEEQSEKQERLEQRDRQRRDEELWRQR-QEWQEREERRAEEEQLQSCK------- 197
Query: 3505 GTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENID-----EIIL 3559
HE E + Q +L L +K E Q + + +D ++ +E E +L
Sbjct: 198 ----GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253
Query: 3560 QLQKLTGQQGEEP----SLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMK 3615
+ ++ Q+ EEP L L + LR+ + Q + LR K
Sbjct: 254 RKEEEKLQE-EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR---K 309
Query: 3616 LEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK 3675
EE+ R Q R+ R E + E+E ++L ++ +R E ++ +
Sbjct: 310 QEEERR--EQQEERREQQERREQQEERR-EQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 3676 LKAELRNDSLLQ 3687
+ E R + L+
Sbjct: 367 EQEEERREQQLR 378
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 191 bits (486), Expect = 9e-48
Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)
Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
+++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ +
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
QL QR + E + R EE EA K+ + E+L ++++ S Q +
Sbjct: 1460 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1513
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
+ E+ + E E R+ + + L R ++A RL + +E + ET
Sbjct: 1514 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1570
Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
RS++++ + +E A ++ + EEH V
Sbjct: 1571 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1603
Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
+++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
K E RE+ R+ + ++++ +E + L ++ + E A + AE +
Sbjct: 1664 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720
Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
E E+Q Q + + RL++E A+ + QELEAE +++ E E+L
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
+ K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++
Sbjct: 1781 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
+ E + K + L+++ E + E++R+ +++A R + Q +E++L
Sbjct: 1840 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Q R+ + L+ + + L + Q++ +I EK
Sbjct: 1896 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
ELE L + DT + E +A+ E + + QL AE R+A +R +K +
Sbjct: 1943 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1994
Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
EE Q + L EEV++L ++E ++ QE ++ +L ++ +K A
Sbjct: 1995 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
+++ A + Q + + Q +Q+++ +DQL + ++Q + +
Sbjct: 2051 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
+ +EE L + E Q + Q ++ R+E + E + Q E A + QK + +
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2164
Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
A E + K + + +K +EQ E+T ++ L+ET+ + N L +EL L
Sbjct: 2165 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2212
Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
K E + +S E SV V ++ LSK K +E L+ +N F EE
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2271
Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
K + E L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2326
Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
A L+ Q Q E QE A+ Q+++ ++ Q + R+ E+ ++ L
Sbjct: 2327 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
LR++E+ E ++H + + +E+V + + +++++ +
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445
Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
++L E + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L
Sbjct: 2446 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
K K E+L ++ + K + Q+ + Q R L + E+ + E E
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 2756 TEVQESKK 2763
V+ ++
Sbjct: 2564 EGVRRKQE 2571
Score = 167 bits (424), Expect = 1e-40
Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)
Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
PE + S L+ + KL + S ++ LE K + R Q A E L+
Sbjct: 1054 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1108
Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
EE + +E AV + E + +K + + Q+ T D L EL A
Sbjct: 1109 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1156
Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R
Sbjct: 1157 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1213
Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
+ L+ D + + + + + + +Q QAL +++E+ + ++E Q
Sbjct: 1214 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
+++ + E+Q + + QL+ V P+ Q SE +E L H E T S+
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1332
Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
I+ +E + ++E R EQ Q+ E+R+ VEA
Sbjct: 1333 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1373
Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
E + + QAER+A + R ++E+ EE +++ + EE+QQL E +
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
+ + + E+ ++++ + L ++ ++ + L A+ +E E + Q
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1492
Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
E+ +L++Q ++++++ R E ++ + + R ++ ++ L E+
Sbjct: 1493 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1541
Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
+LQ +EEA+ Q +V A ++ ALE +A E+ +
Sbjct: 1542 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584
Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
E ++ + SL+ E +V +++ E + + + E E L LK
Sbjct: 1585 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1637
Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
+ E L RL Q E K L + KQ ++ + + G+
Sbjct: 1638 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
E + ++++ + Q++ +++ A +Q +L A QE + + +E E+ Q Q
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1730
Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
L E+EL + +A T + ELE+++ ++ L+ K + E ++ EK K+ LE
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790
Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
E ++ +E R E K +L EE EA R AE +A
Sbjct: 1791 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1843
Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
E K +AE +E + + L +D + Q H A+ +E+L+ L K +
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
+E++ K + E L +K S A+ L++ I+
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1952
Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
N + S+E E+ + ++ +E E + + ++ E R+ A+
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 2008
Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
EE LKA ++ R +E + +LA A Q E + + Q + T
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
Q + + RGE +E+A + A E +V + E+ S + +++
Sbjct: 2069 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
+ E+ +A ++ + L + + + R A+ ++ + +D E +
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
L +++ + T L TD N L++ +Q E A + + R
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
+ E+ L A++ R + L+ + +++ QE E K Q+ E LS A
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2290
Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
L Q++ +EKM+ ++++ T+L+ E L Q K L + +A RL+
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2350
Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
+ L +T E ++ R+L+ + E E+ KL R++ R +E+ + +
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410
Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
E ++ L L Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++
Sbjct: 2411 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468
Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
++ S + + LQ + QS L +D L + ++ +E++ +++ +L +
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2526
Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
++ + + + +QQME++RQ + + + +EA + ++ K E+LQ+ +++RQQ
Sbjct: 2527 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
L E QRL+ +Q ++Q
Sbjct: 2584 EELLAEENQRLREQLQLLEEQ 2604
Score = 158 bits (399), Expect = 1e-37
Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)
Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
+PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ +
Sbjct: 1060 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118
Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
L A+L++ R + + F L ++ +Q++ + QQ +
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178
Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1235
Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
+ +S +E++++++ ++EE+ +K E + + + + Q+V
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1291
Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
+++ + K + S +E L EL + +F ++ ++RME+E +R
Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1350
Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
EQ RAE L E + Q Q ++E EE+ R + ++
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410
Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
+ S + E+ +L + E+ K + + + +++EE+ ++ LE
Sbjct: 1411 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1525
Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
+A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1583
Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + +
Sbjct: 1584 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640
Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
+ + Q E+++ K L Q+ E +K+ E +E + +G EQ V+
Sbjct: 1641 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1685
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
+ +L + LEKQ + E Q++ A AE +++ L+ T +++R +
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1733
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
+ + + ++E ++ ++L+ + ++ E+ E+ R+T +++
Sbjct: 1734 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787
Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
E ++EL EE A L + ++ E+ +Q E + KL A+ E
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847
Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
L+ +K K + + ED+ F LE E + ++ E+L ++ K E
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1905
Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + +
Sbjct: 1906 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
+ + L+ + R + +V KS E + + K + E + + +E
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
L L+ Q + +LQ E + +Q + LQ Q+ +
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2075
Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
+DQ+R E + +A +E + A+ E + +++ + E +E
Sbjct: 2076 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
KL+K +E + Q + L + + E + + E Q R
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2180
Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
+ Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+
Sbjct: 2181 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2233
Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
Q E ++ L++++QAV E+T L + + A+R +
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353
Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
+ + +E + LE + Q QLE + + +A E+SR
Sbjct: 2354 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2397
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
E A + A E+ + E+ + QT E + + + L + + E +
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457
Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
E + + + + T+ +E ++ T ++QS E S + R + + +
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2515
Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
+ E L++E + L E+L+ L++ +LA E++ ++ NG +
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Score = 149 bits (376), Expect = 5e-35
Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)
Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
A E++ +R I E DI +LE C + + L + + RE R E KA+A
Sbjct: 976 AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1031
Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
G +L E EK++ E A +R +L+ + LE QV +
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1085
Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
EK + + + Q E+ L + L E QA+ E + + ++KL Q + P
Sbjct: 1086 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1145
Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
F + + + R +++ L+++ ++ E+ +E++ + ++ + + + R RELEQ
Sbjct: 1146 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
L +++ D +A+ + Q+QA A + +E E+ L EE
Sbjct: 1205 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1257
Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
+E E+V++ K+ +++ E + +K +E + K+ S +
Sbjct: 1258 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1311
Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
+IQE +E T Q +K + E +R +E + E L Q
Sbjct: 1312 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1354
Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
+R R E+E +EK Q++LA + A ++E + Q +VV E+ A+
Sbjct: 1355 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1409
Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
+ Q + K ++E ++ Q ++ E+ + R+ E+ E+
Sbjct: 1410 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1445
Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
S+ + E E+ + L++ E Q +G + L R + E+ E +
Sbjct: 1446 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1498
Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
+Q++D Q + Q E E+ + + E++ A + +++L+A +E + + +
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1557
Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
+ + ++ + E EL S ++ + ++LE + E H ++ +E+ E +
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
E E+ E ++ LE + K E +++S E K E G
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677
Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
E +A+R +A + EL ++ AE ++ L E + L+ + Q +E+
Sbjct: 1678 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735
Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
L+ L++E Q E++ A + + + L+ ++ + S+S ++ Q L
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1792
Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
AG L E + E + Q E+ Q A +L + I E LK E
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
+A LKE + E + LA +A+Q R +
Sbjct: 1853 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
+SDS + +G+ L F+ A+ G+ E +A D
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
+ K + L A Q+ + E + E+ + ++ E +RKA + + LK
Sbjct: 1958 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015
Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
+ + + RE +S++ + + + L A LQQ +E+SV
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075
Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
L A + E A + V L+Q +EQ + QAA
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
E L+K + QA A + ++ ++ +K +++ L Q +Q ++ ++++
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2194
Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
L + L E+L K E + +Q + EL +++ Q + L +L+A R+E +++
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2252
Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
+ ++T Q+++ +++ E+ E A+L + E D + L +
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312
Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
+K + +Q LL+QQK+L E ++++ + QL+EE QG
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
R LE+ E K+R+ EMS R E + + ++ G+ R L +++ +
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
E+Q+Q E I EL E EK K + +QT QQ + ++ Q +
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
++ +E+++ + ++ + + ++K+E L Q+ EE+++Q +++ E QRL M
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552
Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
+E ++++ E EE ++ Q L +
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQ 2578
Score = 146 bits (369), Expect = 3e-34
Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)
Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
QL ++ +E VI Y D +T L + I+ ++ +
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
+ + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + +
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1516
Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
LA+ +K + + E K++ + ++E + E+ E R+R+ E + + V+ +T Q+
Sbjct: 1517 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572
Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
+ R F A+ E SL+ QL+ E + +++ E E+ E+ E
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
+ K E +L +Q E ++ + E E++ + + + + G A
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1679
Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
+E+ V +L EQ + Q+QL T + + + ELIR L ++
Sbjct: 1680 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1721
Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
E E++ + L E + +LQ+E A QK L E ++ +++V++A K
Sbjct: 1722 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1773
Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
E++ + +E+ K L+ + +L +E L+ E ++ + + E
Sbjct: 1774 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
AI ++ K E E+ L E + L+ L F + EE +
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
+E RL QL A D EL + ++D Q + ++++I+ L+ E+ A
Sbjct: 1891 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1943
Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
+++L ++ A+ T+ S+ + L R+ +L ++ R E E +V
Sbjct: 1944 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1991
Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
+ SL E+E K LE+ ++L K ++ RE+ ++ S + +++ +
Sbjct: 1992 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
+ + L+AE KA + ++K ++LQ+ L +++ + L+ +
Sbjct: 2044 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
R EA+E E+E +V+E+++ + + + K +
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
+ + A ++ ++ E+ + Q +K + QEL + + ET+
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2200
Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
K LL EE LKA +++ S + E S Q E+ +
Sbjct: 2201 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2246
Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
I +E R + T F ++ ++ V E ++ + E
Sbjct: 2247 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2290
Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
++Q++E L +++A K L KMQ +EA + LL
Sbjct: 2291 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2334
Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
Q+ +E++ L + ++ + G LE Q Q +E A E L+ R +
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2391
Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
+S QA A+ + ++ + E+ EK + E Q+K + + ++++ A L
Sbjct: 2392 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
+E +AEL+ E + KL+ E L LK E ++ + E L +
Sbjct: 2449 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
SE+ + + +E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2548
Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
S + E++R ++A+ +E+ + LE Q LL E R+RE L+ +
Sbjct: 2549 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
H++ ++ ++ D L + E +HS
Sbjct: 2607 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645
Score = 142 bits (359), Expect = 5e-33
Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)
Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
DI ++E R + +LR LD+ ++ Q + Q AQ E+E +
Sbjct: 991 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1038
Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
+ ++ +++ + + A L +L+ T + E+++ + LE+ + R
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098
Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
+ E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
+ L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1217
Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
+ L++ + +I L D+ + + +Q L E+ +K+E Q F K +
Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277
Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
++ + ++ L+ +K ++ + +E LR E TL + +
Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337
Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
E + E E+ +++ + +E+ A++EA L+ +++ E + +E +
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1391
Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
++ + ++ V +E E D +QQ + EE+++ R + +E + ++ +
Sbjct: 1392 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1441
Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
L++++++ + + E + + A E LQ + + + A
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1487
Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
+ + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1543
Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
+ E+ R R+ E+ RA VQ + R AE + SF E+
Sbjct: 1544 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1588
Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
+ + E S QE+ + + + +E+ RA Q +E ++ ++E +E
Sbjct: 1589 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1628
Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
+ R Q++A + + V Q + + E +K +EE +E ++
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1677
Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
+ E Q ++ +E ++ K L G Q+ ++ E L+ E
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1723
Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
+++ + E E LQ ++ + L KV E LL SK +
Sbjct: 1724 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1775
Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
+ E ++ L E F + + L + K + + L + Q E
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1831
Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
E +++ + E T EAEI +K RL+ ++E ++ ++D
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
+ + + ++K D +E + G+ E+T + + Q+EEE+ + S A A
Sbjct: 1892 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1939
Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
+ EL RI E+T SK Q ++E+ E
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
Q + + E + K +E + + E +++ L+ E K +
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059
Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
++ +T QS+ D++ + A R ++ E + RQ E ++Q
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
E Q QA ++ ++ E + + Q E L ++ A + ++ +E R
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
++ +E EL L+ QL +K L EL+ + + +VEE+ F + +
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
+ I + R + + + + L E + V E R S +Q +A
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2292
Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
L +E + + + + E+ + +++ + + +++ ++ EL+Q R
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2344
Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
+ + E++ ++ Q ++ LEA E S++ E K+ E+ R R
Sbjct: 2345 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398
Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
+++A K EE+ E+LH A ++ + E Q Q+
Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2444
Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
+RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L +
Sbjct: 2445 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2494
Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+
Sbjct: 2495 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2590
Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
+ E L E+ R +EE+ + + + T D A EA
Sbjct: 2591 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2640
Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
+PE S + L+ + A +E I + EE
Sbjct: 2641 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2668
Score = 140 bits (353), Expect = 2e-32
Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)
Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
QE +LE L ++ Q V MK L Q + + ++ +RS+S T
Sbjct: 866 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 914
Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
+ + A++ L + Q + + G E++ +R+ S +Q
Sbjct: 915 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 967
Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
+ ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L +
Sbjct: 968 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1012
Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
++ R+AE Q +AE+E L + L + E++ L E + E L
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1069
Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
+ +Q+ L +K++T+ + L +LK+ Q
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129
Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
+ +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
+ A+ + + E + L L+ + S + +L + + +++I+ + + +++
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1242
Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
+++Q Q L EEIE+ ++ + +++ L+ K LE + +
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1301
Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+
Sbjct: 1302 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1355
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
+RE+L + + QL + H + E E K L+Q ++ +R RE + +
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1414
Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
++Q Q+ + + +R AE + E S++ +E+++ + +
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1465
Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
+Q L +LRA +E + QK ++E+ ++Q E+QR + V
Sbjct: 1466 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
+ EK +AL +L+E + A+E + + E+++ Q+++ Q + +
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1575
Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
+LQ + Q S+ E+ A E + + E+ E
Sbjct: 1576 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
+ R++++ + L + + L + K ++ + + E+ + + E
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
+ Q E + +L++ Q+L + + E + E + + L+++L ++
Sbjct: 1689 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1743
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
A QKR + +E + + V+ S A+ S +K+ +G F
Sbjct: 1744 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
+ EE ++ L E + Q QL EE A + A A++ +++ E T +A
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1853
Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
++++ ++ + FQ + L ++ +H DI
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1891
Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
E + S+ + K + +RQ E + ++ AS + + ++ +
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
R A + LR ++E R+ Q +EE +R + + S+ E + + +
Sbjct: 1952 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
LEE+E LK R + S+ Q Q E Q E + F KE+EL
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
+ + E + L E R A ++A ++ E ++ VEE L +S
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2120
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
++ Q+ A ++ AE K E R E ++ +D +++ T +
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
++ Q L E D + + L+ RL+A + S+ +L +V E
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
+ ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
ET+ + +LE+ +AE+++ +D Q+ K E ++ E++
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2418
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2472
Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
E QT + EQL ++T + LS++ + +R IE+ + ++ +
Sbjct: 2473 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2518
Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
L Q + A ++ + R+ + + L S+E + + +A + RK++E+ LE+
Sbjct: 2519 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578
Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Q Q E L +N+ +++ LE Q + + +E+
Sbjct: 2579 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Score = 122 bits (306), Expect = 7e-27
Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)
Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
A E ++ + + QAE + + K + L + E+ L + L +LE+
Sbjct: 1016 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1069
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
+ +L+++ + ++ + ++ + L I+ + A H K AQ + E++
Sbjct: 1070 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1127
Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
+ KL+ Q + + + +R + E L R+ E+E+ E +
Sbjct: 1128 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1181
Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
+L + + +T + L + L++ + A+ L A Q E++ M
Sbjct: 1182 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1237
Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
L ++ QL QE L ++R E VE+ Q + +N D+ EL++V +
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1291
Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
L+ + + K ++G S+I +L T +L + S +++ +++++ +
Sbjct: 1292 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350
Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
+ Q++ +++ E V AAL Q QL AK +E E +Q
Sbjct: 1351 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1395
Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
Q +R +E D I E Q+ + + I K Q E AE++ L E+++
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
++ LE E+++ G EL+ALRA + +A+
Sbjct: 1456 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1488
Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
+E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q +
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548
Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
++ ++ Q L+ + + ++ K A + Q E S +E ++
Sbjct: 1549 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1604
Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
Q E+ E+ + A AE E+ E LK + ++L EE K++ Q K
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664
Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
+ A A + RE+ + +EG ++ +A
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1711
Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
+ LRA +G Q L E + + + +Q E L + +A +
Sbjct: 1712 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766
Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
+ + K K + + EAE + E + R A +Q L E
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826
Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
E A+G L+ + E +A E L++ A +R L E A
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K S
Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1933
Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
EK AEL+ EL + + E TL++ K ELEA R A E
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1979
Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
+++ RE + ++K A + R + EE+E LK +E ++ + +Q QL
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
E+ QK E + + Q E+ ELQ L+ E+ + ++ + R
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094
Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Q
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
+ +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL+
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214
Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
E +Q + EE+ S R+ + L++ L+ +IE E + L
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2254
Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
I + T L+ +K++ VA + L A E + +ED + Q + E +
Sbjct: 2255 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2311
Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
L+ E+ V +T + E LL+Q EL ++ +E D M +L E
Sbjct: 2312 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2359
Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
+ + +++T L + +++E E + ++ RAE A+ ++
Sbjct: 2360 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
+AE + L +T E VTL
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTL 2430
Score = 48.5 bits (114), Expect = 1e-04
Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)
Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
LL LEQ QE+ C + +SE++ + Q+ R + R ++
Sbjct: 968 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014
Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
P++E + +Q+++Q E+ + L + +EK++ S A T + EL
Sbjct: 1015 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1067
Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
E TL + + ++ L A LE K KT + + A E ++ E Q +
Sbjct: 1068 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1125
Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
E K L+ L+ E+Q+ L L +++ QQ+ +R + + E +
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1184
Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
LE Q +L VR RE+ L RE L A LQ + + +P D +
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1243
Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
+++QL ++ + + E+ EK + +Q + KD ++ T + + E KK
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
++QS E + ++ + R +L L Q ++ I + ++ E E + R + L
Sbjct: 1304 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
E +L R + + + + + AK ++ E + +Q+ + +
Sbjct: 1363 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
+LQ L Q + +Q + A + + ++E I + LQL+ Q+G +
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
+ E RQ E + Q+ +E R ++L +++ + A R+
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1536
Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
++A A +E E + ++ L+ + + AEAE+ +A + S
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
EHV + + LR E+ R+A
Sbjct: 1597 QEEHVAVAQ-----LREEAERRA 1614
Score = 35.8 bits (81), Expect = 0.86
Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)
Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
+E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
D + Q E+ R E + T+++TL + + H+ E +E+
Sbjct: 2400 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2458
Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
+ E K L EE V Q Q + L ++
Sbjct: 2459 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
IE+ +LE++ + Q +E + +Q + +L A++++ARR + E
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H
Sbjct: 2569 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2605
Score = 35.0 bits (79), Expect = 1.5
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
+QLN+ LQ +++ KV + E+ RDL ++ I L +D + +K R + EQ
Sbjct: 410 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 469
Query: 2352 LNEVIEKLQQELANI 2366
+ + +L + L I
Sbjct: 470 MYRRVYRLHERLVAI 484
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 191 bits (486), Expect = 9e-48
Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)
Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
+++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ +
Sbjct: 1404 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1463
Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
QL QR + E + R EE EA K+ + E+L ++++ S Q +
Sbjct: 1464 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1517
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
+ E+ + E E R+ + + L R ++A RL + +E + ET
Sbjct: 1518 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1574
Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
RS++++ + +E A ++ + EEH V
Sbjct: 1575 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1607
Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
+++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667
Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
K E RE+ R+ + ++++ +E + L ++ + E A + AE +
Sbjct: 1668 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1724
Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
E E+Q Q + + RL++E A+ + QELEAE +++ E E+L
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
+ K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++
Sbjct: 1785 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
+ E + K + L+++ E + E++R+ +++A R + Q +E++L
Sbjct: 1844 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899
Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Q R+ + L+ + + L + Q++ +I EK
Sbjct: 1900 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
ELE L + DT + E +A+ E + + QL AE R+A +R +K +
Sbjct: 1947 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1998
Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
EE Q + L EEV++L ++E ++ QE ++ +L ++ +K A
Sbjct: 1999 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
+++ A + Q + + Q +Q+++ +DQL + ++Q + +
Sbjct: 2055 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111
Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
+ +EE L + E Q + Q ++ R+E + E + Q E A + QK + +
Sbjct: 2112 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2168
Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
A E + K + + +K +EQ E+T ++ L+ET+ + N L +EL L
Sbjct: 2169 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2216
Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
K E + +S E SV V ++ LSK K +E L+ +N F EE
Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2275
Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
K + E L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K
Sbjct: 2276 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2330
Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
A L+ Q Q E QE A+ Q+++ ++ Q + R+ E+ ++ L
Sbjct: 2331 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389
Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
LR++E+ E ++H + + +E+V + + +++++ +
Sbjct: 2390 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2449
Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
++L E + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L
Sbjct: 2450 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2507
Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
K K E+L ++ + K + Q+ + Q R L + E+ + E E
Sbjct: 2508 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2567
Query: 2756 TEVQESKK 2763
V+ ++
Sbjct: 2568 EGVRRKQE 2575
Score = 167 bits (424), Expect = 1e-40
Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)
Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
PE + S L+ + KL + S ++ LE K + R Q A E L+
Sbjct: 1058 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1112
Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
EE + +E AV + E + +K + + Q+ T D L EL A
Sbjct: 1113 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1160
Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R
Sbjct: 1161 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1217
Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
+ L+ D + + + + + + +Q QAL +++E+ + ++E Q
Sbjct: 1218 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1276
Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
+++ + E+Q + + QL+ V P+ Q SE +E L H E T S+
Sbjct: 1277 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1336
Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
I+ +E + ++E R EQ Q+ E+R+ VEA
Sbjct: 1337 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1377
Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
E + + QAER+A + R ++E+ EE +++ + EE+QQL E +
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1437
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
+ + + E+ ++++ + L ++ ++ + L A+ +E E + Q
Sbjct: 1438 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1496
Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
E+ +L++Q ++++++ R E ++ + + R ++ ++ L E+
Sbjct: 1497 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1545
Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
+LQ +EEA+ Q +V A ++ ALE +A E+ +
Sbjct: 1546 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1588
Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
E ++ + SL+ E +V +++ E + + + E E L LK
Sbjct: 1589 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1641
Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
+ E L RL Q E K L + KQ ++ + + G+
Sbjct: 1642 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683
Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
E + ++++ + Q++ +++ A +Q +L A QE + + +E E+ Q Q
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1734
Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
L E+EL + +A T + ELE+++ ++ L+ K + E ++ EK K+ LE
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1794
Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
E ++ +E R E K +L EE EA R AE +A
Sbjct: 1795 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1847
Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
E K +AE +E + + L +D + Q H A+ +E+L+ L K +
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907
Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
+E++ K + E L +K S A+ L++ I+
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1956
Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
N + S+E E+ + ++ +E E + + ++ E R+ A+
Sbjct: 1957 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 2012
Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
EE LKA ++ R +E + +LA A Q E + + Q + T
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
Q + + RGE +E+A + A E +V + E+ S + +++
Sbjct: 2073 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2121
Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
+ E+ +A ++ + L + + + R A+ ++ + +D E +
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181
Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
L +++ + T L TD N L++ +Q E A + + R
Sbjct: 2182 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2239
Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
+ E+ L A++ R + L+ + +++ QE E K Q+ E LS A
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2294
Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
L Q++ +EKM+ ++++ T+L+ E L Q K L + +A RL+
Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2354
Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
+ L +T E ++ R+L+ + E E+ KL R++ R +E+ + +
Sbjct: 2355 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2414
Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
E ++ L L Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++
Sbjct: 2415 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2472
Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
++ S + + LQ + QS L +D L + ++ +E++ +++ +L +
Sbjct: 2473 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2530
Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
++ + + + +QQME++RQ + + + +EA + ++ K E+LQ+ +++RQQ
Sbjct: 2531 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2587
Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
L E QRL+ +Q ++Q
Sbjct: 2588 EELLAEENQRLREQLQLLEEQ 2608
Score = 158 bits (399), Expect = 1e-37
Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)
Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
+PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ +
Sbjct: 1064 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1122
Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
L A+L++ R + + F L ++ +Q++ + QQ +
Sbjct: 1123 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1182
Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q
Sbjct: 1183 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1239
Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
+ +S +E++++++ ++EE+ +K E + + + + Q+V
Sbjct: 1240 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1295
Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
+++ + K + S +E L EL + +F ++ ++RME+E +R
Sbjct: 1296 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1354
Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
EQ RAE L E + Q Q ++E EE+ R + ++
Sbjct: 1355 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1414
Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
+ S + E+ +L + E+ K + + + +++EE+ ++ LE
Sbjct: 1415 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1471
Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE
Sbjct: 1472 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1529
Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
+A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1587
Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + +
Sbjct: 1588 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1644
Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
+ + Q E+++ K L Q+ E +K+ E +E + +G EQ V+
Sbjct: 1645 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1689
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
+ +L + LEKQ + E Q++ A AE +++ L+ T +++R +
Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1737
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
+ + + ++E ++ ++L+ + ++ E+ E+ R+T +++
Sbjct: 1738 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1791
Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
E ++EL EE A L + ++ E+ +Q E + KL A+ E
Sbjct: 1792 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1851
Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
L+ +K K + + ED+ F LE E + ++ E+L ++ K E
Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1909
Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + +
Sbjct: 1910 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965
Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
+ + L+ + R + +V KS E + + K + E + + +E
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
L L+ Q + +LQ E + +Q + LQ Q+ +
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2079
Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
+DQ+R E + +A +E + A+ E + +++ + E +E
Sbjct: 2080 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2138
Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
KL+K +E + Q + L + + E + + E Q R
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2184
Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
+ Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+
Sbjct: 2185 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2237
Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297
Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
Q E ++ L++++QAV E+T L + + A+R +
Sbjct: 2298 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2357
Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
+ + +E + LE + Q QLE + + +A E+SR
Sbjct: 2358 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2401
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
E A + A E+ + E+ + QT E + + + L + + E +
Sbjct: 2402 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2461
Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
E + + + + T+ +E ++ T ++QS E S + R + + +
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2519
Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q
Sbjct: 2520 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2579
Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
+ E L++E + L E+L+ L++ +LA E++ ++ NG +
Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2635
Score = 149 bits (376), Expect = 5e-35
Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)
Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
A E++ +R I E DI +LE C + + L + + RE R E KA+A
Sbjct: 980 AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1035
Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
G +L E EK++ E A +R +L+ + LE QV +
Sbjct: 1036 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1089
Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
EK + + + Q E+ L + L E QA+ E + + ++KL Q + P
Sbjct: 1090 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1149
Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
F + + + R +++ L+++ ++ E+ +E++ + ++ + + + R RELEQ
Sbjct: 1150 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208
Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
L +++ D +A+ + Q+QA A + +E E+ L EE
Sbjct: 1209 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1261
Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
+E E+V++ K+ +++ E + +K +E + K+ S +
Sbjct: 1262 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1315
Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
+IQE +E T Q +K + E +R +E + E L Q
Sbjct: 1316 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1358
Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
+R R E+E +EK Q++LA + A ++E + Q +VV E+ A+
Sbjct: 1359 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1413
Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
+ Q + K ++E ++ Q ++ E+ + R+ E+ E+
Sbjct: 1414 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1449
Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
S+ + E E+ + L++ E Q +G + L R + E+ E +
Sbjct: 1450 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1502
Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
+Q++D Q + Q E E+ + + E++ A + +++L+A +E + + +
Sbjct: 1503 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1561
Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
+ + ++ + E EL S ++ + ++LE + E H ++ +E+ E +
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1621
Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
E E+ E ++ LE + K E +++S E K E G
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1681
Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
E +A+R +A + EL ++ AE ++ L E + L+ + Q +E+
Sbjct: 1682 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1739
Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
L+ L++E Q E++ A + + + L+ ++ + S+S ++ Q L
Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1796
Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
AG L E + E + Q E+ Q A +L + I E LK E
Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1856
Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
+A LKE + E + LA +A+Q R +
Sbjct: 1857 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901
Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
+SDS + +G+ L F+ A+ G+ E +A D
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961
Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
+ K + L A Q+ + E + E+ + ++ E +RKA + + LK
Sbjct: 1962 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2019
Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
+ + + RE +S++ + + + L A LQQ +E+SV
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2079
Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
L A + E A + V L+Q +EQ + QAA
Sbjct: 2080 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139
Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
E L+K + QA A + ++ ++ +K +++ L Q +Q ++ ++++
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2198
Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
L + L E+L K E + +Q + EL +++ Q + L +L+A R+E +++
Sbjct: 2199 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2256
Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
+ ++T Q+++ +++ E+ E A+L + E D + L +
Sbjct: 2257 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2316
Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
+K + +Q LL+QQK+L E ++++ + QL+EE QG
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2376
Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
R LE+ E K+R+ EMS R E + + ++ G+ R L +++ +
Sbjct: 2377 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436
Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
E+Q+Q E I EL E EK K + +QT QQ + ++ Q +
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2496
Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
++ +E+++ + ++ + + ++K+E L Q+ EE+++Q +++ E QRL M
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2556
Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
+E ++++ E EE ++ Q L +
Sbjct: 2557 EEARRRQHEAEEGVRRKQEELQQLEQ 2582
Score = 146 bits (369), Expect = 3e-34
Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)
Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++
Sbjct: 1227 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286
Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
QL ++ +E VI Y D +T L + I+ ++ +
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346
Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
+ + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q +
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + +
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1520
Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
LA+ +K + + E K++ + ++E + E+ E R+R+ E + + V+ +T Q+
Sbjct: 1521 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576
Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
+ R F A+ E SL+ QL+ E + +++ E E+ E+ E
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
+ K E +L +Q E ++ + E E++ + + + + G A
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1683
Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
+E+ V +L EQ + Q+QL T + + + ELIR L ++
Sbjct: 1684 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1725
Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
E E++ + L E + +LQ+E A QK L E ++ +++V++A K
Sbjct: 1726 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1777
Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
E++ + +E+ K L+ + +L +E L+ E ++ + + E
Sbjct: 1778 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834
Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
AI ++ K E E+ L E + L+ L F + EE +
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894
Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
+E RL QL A D EL + ++D Q + ++++I+ L+ E+ A
Sbjct: 1895 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1947
Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
+++L ++ A+ T+ S+ + L R+ +L ++ R E E +V
Sbjct: 1948 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1995
Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
+ SL E+E K LE+ ++L K ++ RE+ ++ S + +++ +
Sbjct: 1996 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
+ + L+AE KA + ++K ++LQ+ L +++ + L+ +
Sbjct: 2048 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2090
Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
R EA+E E+E +V+E+++ + + + K +
Sbjct: 2091 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150
Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
+ + A ++ ++ E+ + Q +K + QEL + + ET+
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2204
Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
K LL EE LKA +++ S + E S Q E+ +
Sbjct: 2205 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2250
Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
I +E R + T F ++ ++ V E ++ + E
Sbjct: 2251 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2294
Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
++Q++E L +++A K L KMQ +EA + LL
Sbjct: 2295 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2338
Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
Q+ +E++ L + ++ + G LE Q Q +E A E L+ R +
Sbjct: 2339 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2395
Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
+S QA A+ + ++ + E+ EK + E Q+K + + ++++ A L
Sbjct: 2396 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2452
Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
+E +AEL+ E + KL+ E L LK E ++ + E L +
Sbjct: 2453 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2499
Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
SE+ + + +E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2552
Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
S + E++R ++A+ +E+ + LE Q LL E R+RE L+ +
Sbjct: 2553 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2610
Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
H++ ++ ++ D L + E +HS
Sbjct: 2611 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2649
Score = 142 bits (359), Expect = 5e-33
Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)
Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
DI ++E R + +LR LD+ ++ Q + Q AQ E+E +
Sbjct: 995 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1042
Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
+ ++ +++ + + A L +L+ T + E+++ + LE+ + R
Sbjct: 1043 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1102
Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
+ E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E
Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1162
Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
+ L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E
Sbjct: 1163 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1221
Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
+ L++ + +I L D+ + + +Q L E+ +K+E Q F K +
Sbjct: 1222 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1281
Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
++ + ++ L+ +K ++ + +E LR E TL + +
Sbjct: 1282 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1341
Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
E + E E+ +++ + +E+ A++EA L+ +++ E + +E +
Sbjct: 1342 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1395
Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
++ + ++ V +E E D +QQ + EE+++ R + +E + ++ +
Sbjct: 1396 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1445
Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
L++++++ + + E + + A E LQ + + + A
Sbjct: 1446 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1491
Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
+ + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+
Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1547
Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
+ E+ R R+ E+ RA VQ + R AE + SF E+
Sbjct: 1548 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1592
Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
+ + E S QE+ + + + +E+ RA Q +E ++ ++E +E
Sbjct: 1593 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1632
Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
+ R Q++A + + V Q + + E +K +EE +E ++
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1681
Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
+ E Q ++ +E ++ K L G Q+ ++ E L+ E
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1727
Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
+++ + E E LQ ++ + L KV E LL SK +
Sbjct: 1728 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1779
Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
+ E ++ L E F + + L + K + + L + Q E
Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1835
Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
E +++ + E T EAEI +K RL+ ++E ++ ++D
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895
Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
+ + + ++K D +E + G+ E+T + + Q+EEE+ + S A A
Sbjct: 1896 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1943
Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
+ EL RI E+T SK Q ++E+ E
Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003
Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
Q + + E + K +E + + E +++ L+ E K +
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2063
Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
++ +T QS+ D++ + A R ++ E + RQ E ++Q
Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123
Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
E Q QA ++ ++ E + + Q E L ++ A + ++ +E R
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183
Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
++ +E EL L+ QL +K L EL+ + + +VEE+ F + +
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
+ I + R + + + + L E + V E R S +Q +A
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2296
Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
L +E + + + + E+ + +++ + + +++ ++ EL+Q R
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2348
Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
+ + E++ ++ Q ++ LEA E S++ E K+ E+ R R
Sbjct: 2349 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2402
Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
+++A K EE+ E+LH A ++ + E Q Q+
Sbjct: 2403 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2448
Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
+RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L +
Sbjct: 2449 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2498
Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+
Sbjct: 2499 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2594
Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
+ E L E+ R +EE+ + + + T D A EA
Sbjct: 2595 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2644
Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
+PE S + L+ + A +E I + EE
Sbjct: 2645 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2672
Score = 140 bits (353), Expect = 2e-32
Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)
Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
QE +LE L ++ Q V MK L Q + + ++ +RS+S T
Sbjct: 870 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 918
Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
+ + A++ L + Q + + G E++ +R+ S +Q
Sbjct: 919 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 971
Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
+ ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L +
Sbjct: 972 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1016
Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
++ R+AE Q +AE+E L + L + E++ L E + E L
Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1073
Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
+ +Q+ L +K++T+ + L +LK+ Q
Sbjct: 1074 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1133
Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
+ +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++
Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1193
Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
+ A+ + + E + L L+ + S + +L + + +++I+ + + +++
Sbjct: 1194 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1246
Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
+++Q Q L EEIE+ ++ + +++ L+ K LE + +
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1305
Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+
Sbjct: 1306 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1359
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
+RE+L + + QL + H + E E K L+Q ++ +R RE + +
Sbjct: 1360 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1418
Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
++Q Q+ + + +R AE + E S++ +E+++ + +
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1469
Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
+Q L +LRA +E + QK ++E+ ++Q E+QR + V
Sbjct: 1470 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521
Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
+ EK +AL +L+E + A+E + + E+++ Q+++ Q + +
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1579
Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
+LQ + Q S+ E+ A E + + E+ E
Sbjct: 1580 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1632
Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
+ R++++ + L + + L + K ++ + + E+ + + E
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1692
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
+ Q E + +L++ Q+L + + E + E + + L+++L ++
Sbjct: 1693 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1747
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
A QKR + +E + + V+ S A+ S +K+ +G F
Sbjct: 1748 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1801
Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
+ EE ++ L E + Q QL EE A + A A++ +++ E T +A
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1857
Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
++++ ++ + FQ + L ++ +H DI
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1895
Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
E + S+ + K + +RQ E + ++ AS + + ++ +
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955
Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
R A + LR ++E R+ Q +EE +R + + S+ E + + +
Sbjct: 1956 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010
Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
LEE+E LK R + S+ Q Q E Q E + F KE+EL
Sbjct: 2011 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070
Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
+ + E + L E R A ++A ++ E ++ VEE L +S
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2124
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
++ Q+ A ++ AE K E R E ++ +D +++ T +
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184
Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
++ Q L E D + + L+ RL+A + S+ +L +V E
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303
Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
+ ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL +
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363
Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
ET+ + +LE+ +AE+++ +D Q+ K E ++ E++
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2422
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK
Sbjct: 2423 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2476
Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
E QT + EQL ++T + LS++ + +R IE+ + ++ +
Sbjct: 2477 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2522
Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
L Q + A ++ + R+ + + L S+E + + +A + RK++E+ LE+
Sbjct: 2523 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2582
Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Q Q E L +N+ +++ LE Q + + +E+
Sbjct: 2583 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619
Score = 122 bits (306), Expect = 7e-27
Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)
Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
A E ++ + + QAE + + K + L + E+ L + L +LE+
Sbjct: 1020 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1073
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
+ +L+++ + ++ + ++ + L I+ + A H K AQ + E++
Sbjct: 1074 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1131
Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
+ KL+ Q + + + +R + E L R+ E+E+ E +
Sbjct: 1132 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1185
Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
+L + + +T + L + L++ + A+ L A Q E++ M
Sbjct: 1186 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1241
Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
L ++ QL QE L ++R E VE+ Q + +N D+ EL++V +
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1295
Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
L+ + + K ++G S+I +L T +L + S +++ +++++ +
Sbjct: 1296 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1354
Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
+ Q++ +++ E V AAL Q QL AK +E E +Q
Sbjct: 1355 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1399
Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
Q +R +E D I E Q+ + + I K Q E AE++ L E+++
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459
Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
++ LE E+++ G EL+ALRA + +A+
Sbjct: 1460 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1492
Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
+E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q +
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552
Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
++ ++ Q L+ + + ++ K A + Q E S +E ++
Sbjct: 1553 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1608
Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
Q E+ E+ + A AE E+ E LK + ++L EE K++ Q K
Sbjct: 1609 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1668
Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
+ A A + RE+ + +EG ++ +A
Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1715
Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
+ LRA +G Q L E + + + +Q E L + +A +
Sbjct: 1716 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1770
Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
+ + K K + + EAE + E + R A +Q L E
Sbjct: 1771 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1830
Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
E A+G L+ + E +A E L++ A +R L E A
Sbjct: 1831 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1890
Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K S
Sbjct: 1891 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1937
Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
EK AEL+ EL + + E TL++ K ELEA R A E
Sbjct: 1938 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1983
Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
+++ RE + ++K A + R + EE+E LK +E ++ + +Q QL
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043
Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
E+ QK E + + Q E+ ELQ L+ E+ + ++ + R
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098
Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Q
Sbjct: 2099 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2158
Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
+ +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL+
Sbjct: 2159 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2218
Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
E +Q + EE+ S R+ + L++ L+ +IE E + L
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2258
Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
I + T L+ +K++ VA + L A E + +ED + Q + E +
Sbjct: 2259 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2315
Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
L+ E+ V +T + E LL+Q EL ++ +E D M +L E
Sbjct: 2316 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2363
Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
+ + +++T L + +++E E + ++ RAE A+ ++
Sbjct: 2364 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412
Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
+AE + L +T E VTL
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTL 2434
Score = 48.5 bits (114), Expect = 1e-04
Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)
Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
LL LEQ QE+ C + +SE++ + Q+ R + R ++
Sbjct: 972 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1018
Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
P++E + +Q+++Q E+ + L + +EK++ S A T + EL
Sbjct: 1019 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1071
Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
E TL + + ++ L A LE K KT + + A E ++ E Q +
Sbjct: 1072 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1129
Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
E K L+ L+ E+Q+ L L +++ QQ+ +R + + E +
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1188
Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
LE Q +L VR RE+ L RE L A LQ + + +P D +
Sbjct: 1189 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1247
Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
+++QL ++ + + E+ EK + +Q + KD ++ T + + E KK
Sbjct: 1248 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1307
Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
++QS E + ++ + R +L L Q ++ I + ++ E E + R + L
Sbjct: 1308 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366
Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
E +L R + + + + + AK ++ E + +Q+ + +
Sbjct: 1367 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422
Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
+LQ L Q + +Q + A + + ++E I + LQL+ Q+G +
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482
Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
+ E RQ E + Q+ +E R ++L +++ + A R+
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1540
Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
++A A +E E + ++ L+ + + AEAE+ +A + S
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
EHV + + LR E+ R+A
Sbjct: 1601 QEEHVAVAQ-----LREEAERRA 1618
Score = 35.8 bits (81), Expect = 0.86
Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)
Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
+E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A
Sbjct: 2344 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2403
Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
D + Q E+ R E + T+++TL + + H+ E +E+
Sbjct: 2404 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2462
Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
+ E K L EE V Q Q + L ++
Sbjct: 2463 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2512
Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
IE+ +LE++ + Q +E + +Q + +L A++++ARR + E
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H
Sbjct: 2573 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2609
Score = 35.0 bits (79), Expect = 1.5
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
+QLN+ LQ +++ KV + E+ RDL ++ I L +D + +K R + EQ
Sbjct: 414 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 473
Query: 2352 LNEVIEKLQQELANI 2366
+ + +L + L I
Sbjct: 474 MYRRVYRLHERLVAI 488
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 191 bits (486), Expect = 9e-48
Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)
Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
+++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ +
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
QL QR + E + R EE EA K+ + E+L ++++ S Q +
Sbjct: 1460 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1513
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
+ E+ + E E R+ + + L R ++A RL + +E + ET
Sbjct: 1514 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1570
Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
RS++++ + +E A ++ + EEH V
Sbjct: 1571 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1603
Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
+++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
K E RE+ R+ + ++++ +E + L ++ + E A + AE +
Sbjct: 1664 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720
Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
E E+Q Q + + RL++E A+ + QELEAE +++ E E+L
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
+ K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++
Sbjct: 1781 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
+ E + K + L+++ E + E++R+ +++A R + Q +E++L
Sbjct: 1840 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Q R+ + L+ + + L + Q++ +I EK
Sbjct: 1896 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
ELE L + DT + E +A+ E + + QL AE R+A +R +K +
Sbjct: 1943 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1994
Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
EE Q + L EEV++L ++E ++ QE ++ +L ++ +K A
Sbjct: 1995 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
+++ A + Q + + Q +Q+++ +DQL + ++Q + +
Sbjct: 2051 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
+ +EE L + E Q + Q ++ R+E + E + Q E A + QK + +
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2164
Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
A E + K + + +K +EQ E+T ++ L+ET+ + N L +EL L
Sbjct: 2165 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2212
Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
K E + +S E SV V ++ LSK K +E L+ +N F EE
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2271
Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
K + E L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2326
Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
A L+ Q Q E QE A+ Q+++ ++ Q + R+ E+ ++ L
Sbjct: 2327 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
LR++E+ E ++H + + +E+V + + +++++ +
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445
Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
++L E + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L
Sbjct: 2446 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
K K E+L ++ + K + Q+ + Q R L + E+ + E E
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 2756 TEVQESKK 2763
V+ ++
Sbjct: 2564 EGVRRKQE 2571
Score = 167 bits (424), Expect = 1e-40
Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)
Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
PE + S L+ + KL + S ++ LE K + R Q A E L+
Sbjct: 1054 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1108
Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
EE + +E AV + E + +K + + Q+ T D L EL A
Sbjct: 1109 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1156
Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R
Sbjct: 1157 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1213
Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
+ L+ D + + + + + + +Q QAL +++E+ + ++E Q
Sbjct: 1214 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
+++ + E+Q + + QL+ V P+ Q SE +E L H E T S+
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1332
Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
I+ +E + ++E R EQ Q+ E+R+ VEA
Sbjct: 1333 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1373
Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
E + + QAER+A + R ++E+ EE +++ + EE+QQL E +
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
+ + + E+ ++++ + L ++ ++ + L A+ +E E + Q
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1492
Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
E+ +L++Q ++++++ R E ++ + + R ++ ++ L E+
Sbjct: 1493 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1541
Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
+LQ +EEA+ Q +V A ++ ALE +A E+ +
Sbjct: 1542 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584
Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
E ++ + SL+ E +V +++ E + + + E E L LK
Sbjct: 1585 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1637
Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
+ E L RL Q E K L + KQ ++ + + G+
Sbjct: 1638 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
E + ++++ + Q++ +++ A +Q +L A QE + + +E E+ Q Q
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1730
Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
L E+EL + +A T + ELE+++ ++ L+ K + E ++ EK K+ LE
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790
Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
E ++ +E R E K +L EE EA R AE +A
Sbjct: 1791 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1843
Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
E K +AE +E + + L +D + Q H A+ +E+L+ L K +
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
+E++ K + E L +K S A+ L++ I+
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1952
Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
N + S+E E+ + ++ +E E + + ++ E R+ A+
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 2008
Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
EE LKA ++ R +E + +LA A Q E + + Q + T
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
Q + + RGE +E+A + A E +V + E+ S + +++
Sbjct: 2069 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
+ E+ +A ++ + L + + + R A+ ++ + +D E +
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
L +++ + T L TD N L++ +Q E A + + R
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
+ E+ L A++ R + L+ + +++ QE E K Q+ E LS A
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2290
Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
L Q++ +EKM+ ++++ T+L+ E L Q K L + +A RL+
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2350
Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
+ L +T E ++ R+L+ + E E+ KL R++ R +E+ + +
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410
Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
E ++ L L Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++
Sbjct: 2411 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468
Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
++ S + + LQ + QS L +D L + ++ +E++ +++ +L +
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2526
Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
++ + + + +QQME++RQ + + + +EA + ++ K E+LQ+ +++RQQ
Sbjct: 2527 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
L E QRL+ +Q ++Q
Sbjct: 2584 EELLAEENQRLREQLQLLEEQ 2604
Score = 158 bits (399), Expect = 1e-37
Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)
Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
+PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ +
Sbjct: 1060 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118
Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
L A+L++ R + + F L ++ +Q++ + QQ +
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178
Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1235
Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
+ +S +E++++++ ++EE+ +K E + + + + Q+V
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1291
Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
+++ + K + S +E L EL + +F ++ ++RME+E +R
Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1350
Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
EQ RAE L E + Q Q ++E EE+ R + ++
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410
Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
+ S + E+ +L + E+ K + + + +++EE+ ++ LE
Sbjct: 1411 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1525
Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
+A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1583
Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + +
Sbjct: 1584 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640
Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
+ + Q E+++ K L Q+ E +K+ E +E + +G EQ V+
Sbjct: 1641 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1685
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
+ +L + LEKQ + E Q++ A AE +++ L+ T +++R +
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1733
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
+ + + ++E ++ ++L+ + ++ E+ E+ R+T +++
Sbjct: 1734 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787
Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
E ++EL EE A L + ++ E+ +Q E + KL A+ E
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847
Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
L+ +K K + + ED+ F LE E + ++ E+L ++ K E
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1905
Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + +
Sbjct: 1906 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
+ + L+ + R + +V KS E + + K + E + + +E
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
L L+ Q + +LQ E + +Q + LQ Q+ +
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2075
Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
+DQ+R E + +A +E + A+ E + +++ + E +E
Sbjct: 2076 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
KL+K +E + Q + L + + E + + E Q R
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2180
Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
+ Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+
Sbjct: 2181 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2233
Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
Q E ++ L++++QAV E+T L + + A+R +
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353
Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
+ + +E + LE + Q QLE + + +A E+SR
Sbjct: 2354 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2397
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
E A + A E+ + E+ + QT E + + + L + + E +
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457
Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
E + + + + T+ +E ++ T ++QS E S + R + + +
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2515
Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
+ E L++E + L E+L+ L++ +LA E++ ++ NG +
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Score = 149 bits (376), Expect = 5e-35
Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)
Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
A E++ +R I E DI +LE C + + L + + RE R E KA+A
Sbjct: 976 AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1031
Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
G +L E EK++ E A +R +L+ + LE QV +
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1085
Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
EK + + + Q E+ L + L E QA+ E + + ++KL Q + P
Sbjct: 1086 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1145
Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
F + + + R +++ L+++ ++ E+ +E++ + ++ + + + R RELEQ
Sbjct: 1146 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
L +++ D +A+ + Q+QA A + +E E+ L EE
Sbjct: 1205 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1257
Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
+E E+V++ K+ +++ E + +K +E + K+ S +
Sbjct: 1258 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1311
Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
+IQE +E T Q +K + E +R +E + E L Q
Sbjct: 1312 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1354
Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
+R R E+E +EK Q++LA + A ++E + Q +VV E+ A+
Sbjct: 1355 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1409
Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
+ Q + K ++E ++ Q ++ E+ + R+ E+ E+
Sbjct: 1410 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1445
Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
S+ + E E+ + L++ E Q +G + L R + E+ E +
Sbjct: 1446 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1498
Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
+Q++D Q + Q E E+ + + E++ A + +++L+A +E + + +
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1557
Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
+ + ++ + E EL S ++ + ++LE + E H ++ +E+ E +
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
E E+ E ++ LE + K E +++S E K E G
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677
Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
E +A+R +A + EL ++ AE ++ L E + L+ + Q +E+
Sbjct: 1678 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735
Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
L+ L++E Q E++ A + + + L+ ++ + S+S ++ Q L
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1792
Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
AG L E + E + Q E+ Q A +L + I E LK E
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
+A LKE + E + LA +A+Q R +
Sbjct: 1853 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
+SDS + +G+ L F+ A+ G+ E +A D
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
+ K + L A Q+ + E + E+ + ++ E +RKA + + LK
Sbjct: 1958 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015
Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
+ + + RE +S++ + + + L A LQQ +E+SV
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075
Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
L A + E A + V L+Q +EQ + QAA
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
E L+K + QA A + ++ ++ +K +++ L Q +Q ++ ++++
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2194
Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
L + L E+L K E + +Q + EL +++ Q + L +L+A R+E +++
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2252
Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
+ ++T Q+++ +++ E+ E A+L + E D + L +
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312
Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
+K + +Q LL+QQK+L E ++++ + QL+EE QG
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
R LE+ E K+R+ EMS R E + + ++ G+ R L +++ +
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
E+Q+Q E I EL E EK K + +QT QQ + ++ Q +
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
++ +E+++ + ++ + + ++K+E L Q+ EE+++Q +++ E QRL M
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552
Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
+E ++++ E EE ++ Q L +
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQ 2578
Score = 146 bits (369), Expect = 3e-34
Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)
Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
QL ++ +E VI Y D +T L + I+ ++ +
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
+ + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + +
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1516
Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
LA+ +K + + E K++ + ++E + E+ E R+R+ E + + V+ +T Q+
Sbjct: 1517 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572
Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
+ R F A+ E SL+ QL+ E + +++ E E+ E+ E
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
+ K E +L +Q E ++ + E E++ + + + + G A
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1679
Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
+E+ V +L EQ + Q+QL T + + + ELIR L ++
Sbjct: 1680 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1721
Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
E E++ + L E + +LQ+E A QK L E ++ +++V++A K
Sbjct: 1722 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1773
Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
E++ + +E+ K L+ + +L +E L+ E ++ + + E
Sbjct: 1774 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
AI ++ K E E+ L E + L+ L F + EE +
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
+E RL QL A D EL + ++D Q + ++++I+ L+ E+ A
Sbjct: 1891 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1943
Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
+++L ++ A+ T+ S+ + L R+ +L ++ R E E +V
Sbjct: 1944 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1991
Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
+ SL E+E K LE+ ++L K ++ RE+ ++ S + +++ +
Sbjct: 1992 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
+ + L+AE KA + ++K ++LQ+ L +++ + L+ +
Sbjct: 2044 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
R EA+E E+E +V+E+++ + + + K +
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
+ + A ++ ++ E+ + Q +K + QEL + + ET+
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2200
Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
K LL EE LKA +++ S + E S Q E+ +
Sbjct: 2201 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2246
Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
I +E R + T F ++ ++ V E ++ + E
Sbjct: 2247 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2290
Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
++Q++E L +++A K L KMQ +EA + LL
Sbjct: 2291 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2334
Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
Q+ +E++ L + ++ + G LE Q Q +E A E L+ R +
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2391
Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
+S QA A+ + ++ + E+ EK + E Q+K + + ++++ A L
Sbjct: 2392 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
+E +AEL+ E + KL+ E L LK E ++ + E L +
Sbjct: 2449 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
SE+ + + +E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2548
Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
S + E++R ++A+ +E+ + LE Q LL E R+RE L+ +
Sbjct: 2549 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
H++ ++ ++ D L + E +HS
Sbjct: 2607 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645
Score = 142 bits (359), Expect = 5e-33
Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)
Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
DI ++E R + +LR LD+ ++ Q + Q AQ E+E +
Sbjct: 991 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1038
Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
+ ++ +++ + + A L +L+ T + E+++ + LE+ + R
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098
Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
+ E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
+ L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1217
Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
+ L++ + +I L D+ + + +Q L E+ +K+E Q F K +
Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277
Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
++ + ++ L+ +K ++ + +E LR E TL + +
Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337
Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
E + E E+ +++ + +E+ A++EA L+ +++ E + +E +
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1391
Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
++ + ++ V +E E D +QQ + EE+++ R + +E + ++ +
Sbjct: 1392 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1441
Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
L++++++ + + E + + A E LQ + + + A
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1487
Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
+ + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1543
Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
+ E+ R R+ E+ RA VQ + R AE + SF E+
Sbjct: 1544 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1588
Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
+ + E S QE+ + + + +E+ RA Q +E ++ ++E +E
Sbjct: 1589 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1628
Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
+ R Q++A + + V Q + + E +K +EE +E ++
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1677
Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
+ E Q ++ +E ++ K L G Q+ ++ E L+ E
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1723
Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
+++ + E E LQ ++ + L KV E LL SK +
Sbjct: 1724 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1775
Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
+ E ++ L E F + + L + K + + L + Q E
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1831
Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
E +++ + E T EAEI +K RL+ ++E ++ ++D
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
+ + + ++K D +E + G+ E+T + + Q+EEE+ + S A A
Sbjct: 1892 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1939
Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
+ EL RI E+T SK Q ++E+ E
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
Q + + E + K +E + + E +++ L+ E K +
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059
Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
++ +T QS+ D++ + A R ++ E + RQ E ++Q
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
E Q QA ++ ++ E + + Q E L ++ A + ++ +E R
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
++ +E EL L+ QL +K L EL+ + + +VEE+ F + +
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
+ I + R + + + + L E + V E R S +Q +A
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2292
Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
L +E + + + + E+ + +++ + + +++ ++ EL+Q R
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2344
Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
+ + E++ ++ Q ++ LEA E S++ E K+ E+ R R
Sbjct: 2345 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398
Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
+++A K EE+ E+LH A ++ + E Q Q+
Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2444
Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
+RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L +
Sbjct: 2445 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2494
Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+
Sbjct: 2495 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2590
Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
+ E L E+ R +EE+ + + + T D A EA
Sbjct: 2591 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2640
Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
+PE S + L+ + A +E I + EE
Sbjct: 2641 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2668
Score = 140 bits (353), Expect = 2e-32
Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)
Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
QE +LE L ++ Q V MK L Q + + ++ +RS+S T
Sbjct: 866 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 914
Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
+ + A++ L + Q + + G E++ +R+ S +Q
Sbjct: 915 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 967
Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
+ ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L +
Sbjct: 968 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1012
Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
++ R+AE Q +AE+E L + L + E++ L E + E L
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1069
Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
+ +Q+ L +K++T+ + L +LK+ Q
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129
Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
+ +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
+ A+ + + E + L L+ + S + +L + + +++I+ + + +++
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1242
Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
+++Q Q L EEIE+ ++ + +++ L+ K LE + +
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1301
Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+
Sbjct: 1302 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1355
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
+RE+L + + QL + H + E E K L+Q ++ +R RE + +
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1414
Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
++Q Q+ + + +R AE + E S++ +E+++ + +
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1465
Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
+Q L +LRA +E + QK ++E+ ++Q E+QR + V
Sbjct: 1466 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
+ EK +AL +L+E + A+E + + E+++ Q+++ Q + +
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1575
Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
+LQ + Q S+ E+ A E + + E+ E
Sbjct: 1576 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
+ R++++ + L + + L + K ++ + + E+ + + E
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
+ Q E + +L++ Q+L + + E + E + + L+++L ++
Sbjct: 1689 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1743
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
A QKR + +E + + V+ S A+ S +K+ +G F
Sbjct: 1744 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
+ EE ++ L E + Q QL EE A + A A++ +++ E T +A
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1853
Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
++++ ++ + FQ + L ++ +H DI
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1891
Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
E + S+ + K + +RQ E + ++ AS + + ++ +
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
R A + LR ++E R+ Q +EE +R + + S+ E + + +
Sbjct: 1952 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
LEE+E LK R + S+ Q Q E Q E + F KE+EL
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
+ + E + L E R A ++A ++ E ++ VEE L +S
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2120
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
++ Q+ A ++ AE K E R E ++ +D +++ T +
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
++ Q L E D + + L+ RL+A + S+ +L +V E
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
+ ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
ET+ + +LE+ +AE+++ +D Q+ K E ++ E++
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2418
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2472
Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
E QT + EQL ++T + LS++ + +R IE+ + ++ +
Sbjct: 2473 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2518
Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
L Q + A ++ + R+ + + L S+E + + +A + RK++E+ LE+
Sbjct: 2519 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578
Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Q Q E L +N+ +++ LE Q + + +E+
Sbjct: 2579 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Score = 122 bits (306), Expect = 7e-27
Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)
Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
A E ++ + + QAE + + K + L + E+ L + L +LE+
Sbjct: 1016 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1069
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
+ +L+++ + ++ + ++ + L I+ + A H K AQ + E++
Sbjct: 1070 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1127
Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
+ KL+ Q + + + +R + E L R+ E+E+ E +
Sbjct: 1128 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1181
Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
+L + + +T + L + L++ + A+ L A Q E++ M
Sbjct: 1182 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1237
Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
L ++ QL QE L ++R E VE+ Q + +N D+ EL++V +
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1291
Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
L+ + + K ++G S+I +L T +L + S +++ +++++ +
Sbjct: 1292 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350
Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
+ Q++ +++ E V AAL Q QL AK +E E +Q
Sbjct: 1351 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1395
Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
Q +R +E D I E Q+ + + I K Q E AE++ L E+++
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
++ LE E+++ G EL+ALRA + +A+
Sbjct: 1456 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1488
Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
+E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q +
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548
Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
++ ++ Q L+ + + ++ K A + Q E S +E ++
Sbjct: 1549 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1604
Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
Q E+ E+ + A AE E+ E LK + ++L EE K++ Q K
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664
Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
+ A A + RE+ + +EG ++ +A
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1711
Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
+ LRA +G Q L E + + + +Q E L + +A +
Sbjct: 1712 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766
Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
+ + K K + + EAE + E + R A +Q L E
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826
Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
E A+G L+ + E +A E L++ A +R L E A
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K S
Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1933
Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
EK AEL+ EL + + E TL++ K ELEA R A E
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1979
Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
+++ RE + ++K A + R + EE+E LK +E ++ + +Q QL
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
E+ QK E + + Q E+ ELQ L+ E+ + ++ + R
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094
Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Q
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
+ +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL+
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214
Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
E +Q + EE+ S R+ + L++ L+ +IE E + L
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2254
Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
I + T L+ +K++ VA + L A E + +ED + Q + E +
Sbjct: 2255 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2311
Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
L+ E+ V +T + E LL+Q EL ++ +E D M +L E
Sbjct: 2312 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2359
Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
+ + +++T L + +++E E + ++ RAE A+ ++
Sbjct: 2360 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
+AE + L +T E VTL
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTL 2430
Score = 48.5 bits (114), Expect = 1e-04
Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)
Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
LL LEQ QE+ C + +SE++ + Q+ R + R ++
Sbjct: 968 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014
Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
P++E + +Q+++Q E+ + L + +EK++ S A T + EL
Sbjct: 1015 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1067
Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
E TL + + ++ L A LE K KT + + A E ++ E Q +
Sbjct: 1068 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1125
Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
E K L+ L+ E+Q+ L L +++ QQ+ +R + + E +
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1184
Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
LE Q +L VR RE+ L RE L A LQ + + +P D +
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1243
Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
+++QL ++ + + E+ EK + +Q + KD ++ T + + E KK
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
++QS E + ++ + R +L L Q ++ I + ++ E E + R + L
Sbjct: 1304 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
E +L R + + + + + AK ++ E + +Q+ + +
Sbjct: 1363 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
+LQ L Q + +Q + A + + ++E I + LQL+ Q+G +
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
+ E RQ E + Q+ +E R ++L +++ + A R+
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1536
Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
++A A +E E + ++ L+ + + AEAE+ +A + S
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
EHV + + LR E+ R+A
Sbjct: 1597 QEEHVAVAQ-----LREEAERRA 1614
Score = 35.8 bits (81), Expect = 0.86
Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)
Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
+E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
D + Q E+ R E + T+++TL + + H+ E +E+
Sbjct: 2400 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2458
Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
+ E K L EE V Q Q + L ++
Sbjct: 2459 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
IE+ +LE++ + Q +E + +Q + +L A++++ARR + E
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H
Sbjct: 2569 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2605
Score = 35.0 bits (79), Expect = 1.5
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
+QLN+ LQ +++ KV + E+ RDL ++ I L +D + +K R + EQ
Sbjct: 410 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 469
Query: 2352 LNEVIEKLQQELANI 2366
+ + +L + L I
Sbjct: 470 MYRRVYRLHERLVAI 484
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 191 bits (486), Expect = 9e-48
Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)
Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
+++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ +
Sbjct: 1368 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1427
Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
QL QR + E + R EE EA K+ + E+L ++++ S Q +
Sbjct: 1428 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1481
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
+ E+ + E E R+ + + L R ++A RL + +E + ET
Sbjct: 1482 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1538
Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
RS++++ + +E A ++ + EEH V
Sbjct: 1539 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1571
Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
+++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631
Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
K E RE+ R+ + ++++ +E + L ++ + E A + AE +
Sbjct: 1632 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1688
Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
E E+Q Q + + RL++E A+ + QELEAE +++ E E+L
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748
Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
+ K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++
Sbjct: 1749 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
+ E + K + L+++ E + E++R+ +++A R + Q +E++L
Sbjct: 1808 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863
Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Q R+ + L+ + + L + Q++ +I EK
Sbjct: 1864 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
ELE L + DT + E +A+ E + + QL AE R+A +R +K +
Sbjct: 1911 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1962
Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
EE Q + L EEV++L ++E ++ QE ++ +L ++ +K A
Sbjct: 1963 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
+++ A + Q + + Q +Q+++ +DQL + ++Q + +
Sbjct: 2019 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075
Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
+ +EE L + E Q + Q ++ R+E + E + Q E A + QK + +
Sbjct: 2076 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2132
Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
A E + K + + +K +EQ E+T ++ L+ET+ + N L +EL L
Sbjct: 2133 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2180
Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
K E + +S E SV V ++ LSK K +E L+ +N F EE
Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2239
Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
K + E L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K
Sbjct: 2240 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2294
Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
A L+ Q Q E QE A+ Q+++ ++ Q + R+ E+ ++ L
Sbjct: 2295 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353
Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
LR++E+ E ++H + + +E+V + + +++++ +
Sbjct: 2354 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2413
Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
++L E + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L
Sbjct: 2414 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2471
Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
K K E+L ++ + K + Q+ + Q R L + E+ + E E
Sbjct: 2472 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2531
Query: 2756 TEVQESKK 2763
V+ ++
Sbjct: 2532 EGVRRKQE 2539
Score = 167 bits (424), Expect = 1e-40
Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)
Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
PE + S L+ + KL + S ++ LE K + R Q A E L+
Sbjct: 1022 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1076
Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
EE + +E AV + E + +K + + Q+ T D L EL A
Sbjct: 1077 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1124
Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R
Sbjct: 1125 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1181
Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
+ L+ D + + + + + + +Q QAL +++E+ + ++E Q
Sbjct: 1182 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1240
Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
+++ + E+Q + + QL+ V P+ Q SE +E L H E T S+
Sbjct: 1241 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1300
Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
I+ +E + ++E R EQ Q+ E+R+ VEA
Sbjct: 1301 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1341
Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
E + + QAER+A + R ++E+ EE +++ + EE+QQL E +
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1401
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
+ + + E+ ++++ + L ++ ++ + L A+ +E E + Q
Sbjct: 1402 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1460
Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
E+ +L++Q ++++++ R E ++ + + R ++ ++ L E+
Sbjct: 1461 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1509
Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
+LQ +EEA+ Q +V A ++ ALE +A E+ +
Sbjct: 1510 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1552
Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
E ++ + SL+ E +V +++ E + + + E E L LK
Sbjct: 1553 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1605
Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
+ E L RL Q E K L + KQ ++ + + G+
Sbjct: 1606 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647
Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
E + ++++ + Q++ +++ A +Q +L A QE + + +E E+ Q Q
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1698
Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
L E+EL + +A T + ELE+++ ++ L+ K + E ++ EK K+ LE
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1758
Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
E ++ +E R E K +L EE EA R AE +A
Sbjct: 1759 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1811
Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
E K +AE +E + + L +D + Q H A+ +E+L+ L K +
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871
Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
+E++ K + E L +K S A+ L++ I+
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1920
Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
N + S+E E+ + ++ +E E + + ++ E R+ A+
Sbjct: 1921 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 1976
Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
EE LKA ++ R +E + +LA A Q E + + Q + T
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
Q + + RGE +E+A + A E +V + E+ S + +++
Sbjct: 2037 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2085
Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
+ E+ +A ++ + L + + + R A+ ++ + +D E +
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145
Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
L +++ + T L TD N L++ +Q E A + + R
Sbjct: 2146 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2203
Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
+ E+ L A++ R + L+ + +++ QE E K Q+ E LS A
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2258
Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
L Q++ +EKM+ ++++ T+L+ E L Q K L + +A RL+
Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2318
Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
+ L +T E ++ R+L+ + E E+ KL R++ R +E+ + +
Sbjct: 2319 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2378
Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
E ++ L L Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++
Sbjct: 2379 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2436
Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
++ S + + LQ + QS L +D L + ++ +E++ +++ +L +
Sbjct: 2437 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2494
Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
++ + + + +QQME++RQ + + + +EA + ++ K E+LQ+ +++RQQ
Sbjct: 2495 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2551
Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
L E QRL+ +Q ++Q
Sbjct: 2552 EELLAEENQRLREQLQLLEEQ 2572
Score = 158 bits (399), Expect = 1e-37
Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)
Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
+PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ +
Sbjct: 1028 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1086
Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
L A+L++ R + + F L ++ +Q++ + QQ +
Sbjct: 1087 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1146
Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q
Sbjct: 1147 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1203
Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
+ +S +E++++++ ++EE+ +K E + + + + Q+V
Sbjct: 1204 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1259
Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
+++ + K + S +E L EL + +F ++ ++RME+E +R
Sbjct: 1260 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1318
Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
EQ RAE L E + Q Q ++E EE+ R + ++
Sbjct: 1319 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1378
Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
+ S + E+ +L + E+ K + + + +++EE+ ++ LE
Sbjct: 1379 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1435
Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE
Sbjct: 1436 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1493
Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
+A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1551
Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + +
Sbjct: 1552 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1608
Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
+ + Q E+++ K L Q+ E +K+ E +E + +G EQ V+
Sbjct: 1609 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1653
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
+ +L + LEKQ + E Q++ A AE +++ L+ T +++R +
Sbjct: 1654 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1701
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
+ + + ++E ++ ++L+ + ++ E+ E+ R+T +++
Sbjct: 1702 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1755
Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
E ++EL EE A L + ++ E+ +Q E + KL A+ E
Sbjct: 1756 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1815
Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
L+ +K K + + ED+ F LE E + ++ E+L ++ K E
Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1873
Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + +
Sbjct: 1874 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929
Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
+ + L+ + R + +V KS E + + K + E + + +E
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
L L+ Q + +LQ E + +Q + LQ Q+ +
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2043
Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
+DQ+R E + +A +E + A+ E + +++ + E +E
Sbjct: 2044 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2102
Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
KL+K +E + Q + L + + E + + E Q R
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2148
Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
+ Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+
Sbjct: 2149 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2201
Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261
Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
Q E ++ L++++QAV E+T L + + A+R +
Sbjct: 2262 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2321
Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
+ + +E + LE + Q QLE + + +A E+SR
Sbjct: 2322 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2365
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
E A + A E+ + E+ + QT E + + + L + + E +
Sbjct: 2366 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2425
Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
E + + + + T+ +E ++ T ++QS E S + R + + +
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2483
Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q
Sbjct: 2484 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2543
Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
+ E L++E + L E+L+ L++ +LA E++ ++ NG +
Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2599
Score = 149 bits (376), Expect = 5e-35
Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)
Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
A E++ +R I E DI +LE C + + L + + RE R E KA+A
Sbjct: 944 AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 999
Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
G +L E EK++ E A +R +L+ + LE QV +
Sbjct: 1000 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1053
Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
EK + + + Q E+ L + L E QA+ E + + ++KL Q + P
Sbjct: 1054 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1113
Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
F + + + R +++ L+++ ++ E+ +E++ + ++ + + + R RELEQ
Sbjct: 1114 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172
Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
L +++ D +A+ + Q+QA A + +E E+ L EE
Sbjct: 1173 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1225
Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
+E E+V++ K+ +++ E + +K +E + K+ S +
Sbjct: 1226 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1279
Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
+IQE +E T Q +K + E +R +E + E L Q
Sbjct: 1280 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1322
Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
+R R E+E +EK Q++LA + A ++E + Q +VV E+ A+
Sbjct: 1323 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1377
Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
+ Q + K ++E ++ Q ++ E+ + R+ E+ E+
Sbjct: 1378 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1413
Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
S+ + E E+ + L++ E Q +G + L R + E+ E +
Sbjct: 1414 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1466
Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
+Q++D Q + Q E E+ + + E++ A + +++L+A +E + + +
Sbjct: 1467 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1525
Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
+ + ++ + E EL S ++ + ++LE + E H ++ +E+ E +
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1585
Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
E E+ E ++ LE + K E +++S E K E G
Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1645
Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
E +A+R +A + EL ++ AE ++ L E + L+ + Q +E+
Sbjct: 1646 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1703
Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
L+ L++E Q E++ A + + + L+ ++ + S+S ++ Q L
Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1760
Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
AG L E + E + Q E+ Q A +L + I E LK E
Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1820
Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
+A LKE + E + LA +A+Q R +
Sbjct: 1821 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865
Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
+SDS + +G+ L F+ A+ G+ E +A D
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925
Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
+ K + L A Q+ + E + E+ + ++ E +RKA + + LK
Sbjct: 1926 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1983
Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
+ + + RE +S++ + + + L A LQQ +E+SV
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2043
Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
L A + E A + V L+Q +EQ + QAA
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103
Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
E L+K + QA A + ++ ++ +K +++ L Q +Q ++ ++++
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2162
Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
L + L E+L K E + +Q + EL +++ Q + L +L+A R+E +++
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2220
Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
+ ++T Q+++ +++ E+ E A+L + E D + L +
Sbjct: 2221 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2280
Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
+K + +Q LL+QQK+L E ++++ + QL+EE QG
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340
Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
R LE+ E K+R+ EMS R E + + ++ G+ R L +++ +
Sbjct: 2341 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2400
Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
E+Q+Q E I EL E EK K + +QT QQ + ++ Q +
Sbjct: 2401 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2460
Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
++ +E+++ + ++ + + ++K+E L Q+ EE+++Q +++ E QRL M
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2520
Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
+E ++++ E EE ++ Q L +
Sbjct: 2521 EEARRRQHEAEEGVRRKQEELQQLEQ 2546
Score = 146 bits (369), Expect = 3e-34
Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)
Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++
Sbjct: 1191 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250
Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
QL ++ +E VI Y D +T L + I+ ++ +
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1310
Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
+ + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q +
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430
Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + +
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1484
Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
LA+ +K + + E K++ + ++E + E+ E R+R+ E + + V+ +T Q+
Sbjct: 1485 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540
Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
+ R F A+ E SL+ QL+ E + +++ E E+ E+ E
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
+ K E +L +Q E ++ + E E++ + + + + G A
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1647
Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
+E+ V +L EQ + Q+QL T + + + ELIR L ++
Sbjct: 1648 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1689
Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
E E++ + L E + +LQ+E A QK L E ++ +++V++A K
Sbjct: 1690 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1741
Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
E++ + +E+ K L+ + +L +E L+ E ++ + + E
Sbjct: 1742 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798
Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
AI ++ K E E+ L E + L+ L F + EE +
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858
Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
+E RL QL A D EL + ++D Q + ++++I+ L+ E+ A
Sbjct: 1859 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1911
Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
+++L ++ A+ T+ S+ + L R+ +L ++ R E E +V
Sbjct: 1912 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1959
Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
+ SL E+E K LE+ ++L K ++ RE+ ++ S + +++ +
Sbjct: 1960 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
+ + L+AE KA + ++K ++LQ+ L +++ + L+ +
Sbjct: 2012 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2054
Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
R EA+E E+E +V+E+++ + + + K +
Sbjct: 2055 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114
Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
+ + A ++ ++ E+ + Q +K + QEL + + ET+
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2168
Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
K LL EE LKA +++ S + E S Q E+ +
Sbjct: 2169 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2214
Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
I +E R + T F ++ ++ V E ++ + E
Sbjct: 2215 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2258
Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
++Q++E L +++A K L KMQ +EA + LL
Sbjct: 2259 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2302
Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
Q+ +E++ L + ++ + G LE Q Q +E A E L+ R +
Sbjct: 2303 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2359
Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
+S QA A+ + ++ + E+ EK + E Q+K + + ++++ A L
Sbjct: 2360 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2416
Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
+E +AEL+ E + KL+ E L LK E ++ + E L +
Sbjct: 2417 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2463
Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
SE+ + + +E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2516
Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
S + E++R ++A+ +E+ + LE Q LL E R+RE L+ +
Sbjct: 2517 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2574
Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
H++ ++ ++ D L + E +HS
Sbjct: 2575 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2613
Score = 142 bits (359), Expect = 5e-33
Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)
Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
DI ++E R + +LR LD+ ++ Q + Q AQ E+E +
Sbjct: 959 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1006
Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
+ ++ +++ + + A L +L+ T + E+++ + LE+ + R
Sbjct: 1007 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1066
Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
+ E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E
Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1126
Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
+ L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E
Sbjct: 1127 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1185
Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
+ L++ + +I L D+ + + +Q L E+ +K+E Q F K +
Sbjct: 1186 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1245
Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
++ + ++ L+ +K ++ + +E LR E TL + +
Sbjct: 1246 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1305
Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
E + E E+ +++ + +E+ A++EA L+ +++ E + +E +
Sbjct: 1306 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1359
Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
++ + ++ V +E E D +QQ + EE+++ R + +E + ++ +
Sbjct: 1360 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1409
Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
L++++++ + + E + + A E LQ + + + A
Sbjct: 1410 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1455
Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
+ + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+
Sbjct: 1456 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1511
Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
+ E+ R R+ E+ RA VQ + R AE + SF E+
Sbjct: 1512 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1556
Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
+ + E S QE+ + + + +E+ RA Q +E ++ ++E +E
Sbjct: 1557 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1596
Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
+ R Q++A + + V Q + + E +K +EE +E ++
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1645
Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
+ E Q ++ +E ++ K L G Q+ ++ E L+ E
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1691
Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
+++ + E E LQ ++ + L KV E LL SK +
Sbjct: 1692 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1743
Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
+ E ++ L E F + + L + K + + L + Q E
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1799
Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
E +++ + E T EAEI +K RL+ ++E ++ ++D
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859
Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
+ + + ++K D +E + G+ E+T + + Q+EEE+ + S A A
Sbjct: 1860 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1907
Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
+ EL RI E+T SK Q ++E+ E
Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967
Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
Q + + E + K +E + + E +++ L+ E K +
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2027
Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
++ +T QS+ D++ + A R ++ E + RQ E ++Q
Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087
Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
E Q QA ++ ++ E + + Q E L ++ A + ++ +E R
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147
Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
++ +E EL L+ QL +K L EL+ + + +VEE+ F + +
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
+ I + R + + + + L E + V E R S +Q +A
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2260
Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
L +E + + + + E+ + +++ + + +++ ++ EL+Q R
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2312
Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
+ + E++ ++ Q ++ LEA E S++ E K+ E+ R R
Sbjct: 2313 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2366
Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
+++A K EE+ E+LH A ++ + E Q Q+
Sbjct: 2367 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2412
Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
+RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L +
Sbjct: 2413 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2462
Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+
Sbjct: 2463 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2558
Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
+ E L E+ R +EE+ + + + T D A EA
Sbjct: 2559 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2608
Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
+PE S + L+ + A +E I + EE
Sbjct: 2609 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2636
Score = 140 bits (353), Expect = 2e-32
Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)
Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
QE +LE L ++ Q V MK L Q + + ++ +RS+S T
Sbjct: 834 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 882
Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
+ + A++ L + Q + + G E++ +R+ S +Q
Sbjct: 883 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 935
Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
+ ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L +
Sbjct: 936 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 980
Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
++ R+AE Q +AE+E L + L + E++ L E + E L
Sbjct: 981 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1037
Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
+ +Q+ L +K++T+ + L +LK+ Q
Sbjct: 1038 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1097
Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
+ +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++
Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1157
Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
+ A+ + + E + L L+ + S + +L + + +++I+ + + +++
Sbjct: 1158 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1210
Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
+++Q Q L EEIE+ ++ + +++ L+ K LE + +
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1269
Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+
Sbjct: 1270 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1323
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
+RE+L + + QL + H + E E K L+Q ++ +R RE + +
Sbjct: 1324 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1382
Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
++Q Q+ + + +R AE + E S++ +E+++ + +
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1433
Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
+Q L +LRA +E + QK ++E+ ++Q E+QR + V
Sbjct: 1434 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1485
Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
+ EK +AL +L+E + A+E + + E+++ Q+++ Q + +
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1543
Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
+LQ + Q S+ E+ A E + + E+ E
Sbjct: 1544 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1596
Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
+ R++++ + L + + L + K ++ + + E+ + + E
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1656
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
+ Q E + +L++ Q+L + + E + E + + L+++L ++
Sbjct: 1657 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1711
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
A QKR + +E + + V+ S A+ S +K+ +G F
Sbjct: 1712 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1765
Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
+ EE ++ L E + Q QL EE A + A A++ +++ E T +A
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1821
Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
++++ ++ + FQ + L ++ +H DI
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1859
Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
E + S+ + K + +RQ E + ++ AS + + ++ +
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919
Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
R A + LR ++E R+ Q +EE +R + + S+ E + + +
Sbjct: 1920 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974
Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
LEE+E LK R + S+ Q Q E Q E + F KE+EL
Sbjct: 1975 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034
Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
+ + E + L E R A ++A ++ E ++ VEE L +S
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2088
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
++ Q+ A ++ AE K E R E ++ +D +++ T +
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148
Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
++ Q L E D + + L+ RL+A + S+ +L +V E
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267
Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
+ ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL +
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327
Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
ET+ + +LE+ +AE+++ +D Q+ K E ++ E++
Sbjct: 2328 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2386
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK
Sbjct: 2387 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2440
Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
E QT + EQL ++T + LS++ + +R IE+ + ++ +
Sbjct: 2441 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2486
Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
L Q + A ++ + R+ + + L S+E + + +A + RK++E+ LE+
Sbjct: 2487 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2546
Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Q Q E L +N+ +++ LE Q + + +E+
Sbjct: 2547 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583
Score = 122 bits (306), Expect = 7e-27
Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)
Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
A E ++ + + QAE + + K + L + E+ L + L +LE+
Sbjct: 984 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1037
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
+ +L+++ + ++ + ++ + L I+ + A H K AQ + E++
Sbjct: 1038 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1095
Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
+ KL+ Q + + + +R + E L R+ E+E+ E +
Sbjct: 1096 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1149
Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
+L + + +T + L + L++ + A+ L A Q E++ M
Sbjct: 1150 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1205
Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
L ++ QL QE L ++R E VE+ Q + +N D+ EL++V +
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1259
Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
L+ + + K ++G S+I +L T +L + S +++ +++++ +
Sbjct: 1260 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1318
Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
+ Q++ +++ E V AAL Q QL AK +E E +Q
Sbjct: 1319 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1363
Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
Q +R +E D I E Q+ + + I K Q E AE++ L E+++
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423
Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
++ LE E+++ G EL+ALRA + +A+
Sbjct: 1424 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1456
Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
+E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q +
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516
Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
++ ++ Q L+ + + ++ K A + Q E S +E ++
Sbjct: 1517 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1572
Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
Q E+ E+ + A AE E+ E LK + ++L EE K++ Q K
Sbjct: 1573 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1632
Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
+ A A + RE+ + +EG ++ +A
Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1679
Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
+ LRA +G Q L E + + + +Q E L + +A +
Sbjct: 1680 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1734
Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
+ + K K + + EAE + E + R A +Q L E
Sbjct: 1735 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1794
Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
E A+G L+ + E +A E L++ A +R L E A
Sbjct: 1795 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1854
Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K S
Sbjct: 1855 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1901
Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
EK AEL+ EL + + E TL++ K ELEA R A E
Sbjct: 1902 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1947
Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
+++ RE + ++K A + R + EE+E LK +E ++ + +Q QL
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007
Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
E+ QK E + + Q E+ ELQ L+ E+ + ++ + R
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062
Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Q
Sbjct: 2063 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2122
Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
+ +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL+
Sbjct: 2123 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2182
Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
E +Q + EE+ S R+ + L++ L+ +IE E + L
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2222
Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
I + T L+ +K++ VA + L A E + +ED + Q + E +
Sbjct: 2223 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2279
Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
L+ E+ V +T + E LL+Q EL ++ +E D M +L E
Sbjct: 2280 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2327
Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
+ + +++T L + +++E E + ++ RAE A+ ++
Sbjct: 2328 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376
Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
+AE + L +T E VTL
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTL 2398
Score = 48.5 bits (114), Expect = 1e-04
Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)
Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
LL LEQ QE+ C + +SE++ + Q+ R + R ++
Sbjct: 936 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 982
Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
P++E + +Q+++Q E+ + L + +EK++ S A T + EL
Sbjct: 983 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1035
Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
E TL + + ++ L A LE K KT + + A E ++ E Q +
Sbjct: 1036 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1093
Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
E K L+ L+ E+Q+ L L +++ QQ+ +R + + E +
Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1152
Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
LE Q +L VR RE+ L RE L A LQ + + +P D +
Sbjct: 1153 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1211
Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
+++QL ++ + + E+ EK + +Q + KD ++ T + + E KK
Sbjct: 1212 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1271
Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
++QS E + ++ + R +L L Q ++ I + ++ E E + R + L
Sbjct: 1272 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330
Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
E +L R + + + + + AK ++ E + +Q+ + +
Sbjct: 1331 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386
Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
+LQ L Q + +Q + A + + ++E I + LQL+ Q+G +
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446
Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
+ E RQ E + Q+ +E R ++L +++ + A R+
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1504
Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
++A A +E E + ++ L+ + + AEAE+ +A + S
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
EHV + + LR E+ R+A
Sbjct: 1565 QEEHVAVAQ-----LREEAERRA 1582
Score = 35.8 bits (81), Expect = 0.86
Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)
Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
+E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A
Sbjct: 2308 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2367
Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
D + Q E+ R E + T+++TL + + H+ E +E+
Sbjct: 2368 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2426
Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
+ E K L EE V Q Q + L ++
Sbjct: 2427 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2476
Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
IE+ +LE++ + Q +E + +Q + +L A++++ARR + E
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2536
Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H
Sbjct: 2537 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2573
Score = 35.0 bits (79), Expect = 1.5
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
+QLN+ LQ +++ KV + E+ RDL ++ I L +D + +K R + EQ
Sbjct: 378 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 437
Query: 2352 LNEVIEKLQQELANI 2366
+ + +L + L I
Sbjct: 438 MYRRVYRLHERLVAI 452
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 191 bits (486), Expect = 9e-48
Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)
Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
+++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ +
Sbjct: 1537 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1596
Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
QL QR + E + R EE EA K+ + E+L ++++ S Q +
Sbjct: 1597 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1650
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
+ E+ + E E R+ + + L R ++A RL + +E + ET
Sbjct: 1651 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1707
Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
RS++++ + +E A ++ + EEH V
Sbjct: 1708 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1740
Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
+++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800
Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
K E RE+ R+ + ++++ +E + L ++ + E A + AE +
Sbjct: 1801 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1857
Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
E E+Q Q + + RL++E A+ + QELEAE +++ E E+L
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
+ K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++
Sbjct: 1918 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
+ E + K + L+++ E + E++R+ +++A R + Q +E++L
Sbjct: 1977 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032
Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Q R+ + L+ + + L + Q++ +I EK
Sbjct: 2033 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
ELE L + DT + E +A+ E + + QL AE R+A +R +K +
Sbjct: 2080 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 2131
Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
EE Q + L EEV++L ++E ++ QE ++ +L ++ +K A
Sbjct: 2132 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
+++ A + Q + + Q +Q+++ +DQL + ++Q + +
Sbjct: 2188 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244
Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
+ +EE L + E Q + Q ++ R+E + E + Q E A + QK + +
Sbjct: 2245 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2301
Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
A E + K + + +K +EQ E+T ++ L+ET+ + N L +EL L
Sbjct: 2302 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2349
Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
K E + +S E SV V ++ LSK K +E L+ +N F EE
Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2408
Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
K + E L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K
Sbjct: 2409 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2463
Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
A L+ Q Q E QE A+ Q+++ ++ Q + R+ E+ ++ L
Sbjct: 2464 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522
Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
LR++E+ E ++H + + +E+V + + +++++ +
Sbjct: 2523 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2582
Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
++L E + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L
Sbjct: 2583 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640
Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
K K E+L ++ + K + Q+ + Q R L + E+ + E E
Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700
Query: 2756 TEVQESKK 2763
V+ ++
Sbjct: 2701 EGVRRKQE 2708
Score = 167 bits (424), Expect = 1e-40
Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)
Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
PE + S L+ + KL + S ++ LE K + R Q A E L+
Sbjct: 1191 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1245
Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
EE + +E AV + E + +K + + Q+ T D L EL A
Sbjct: 1246 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1293
Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R
Sbjct: 1294 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1350
Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
+ L+ D + + + + + + +Q QAL +++E+ + ++E Q
Sbjct: 1351 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1409
Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
+++ + E+Q + + QL+ V P+ Q SE +E L H E T S+
Sbjct: 1410 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1469
Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
I+ +E + ++E R EQ Q+ E+R+ VEA
Sbjct: 1470 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1510
Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
E + + QAER+A + R ++E+ EE +++ + EE+QQL E +
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1570
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
+ + + E+ ++++ + L ++ ++ + L A+ +E E + Q
Sbjct: 1571 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1629
Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
E+ +L++Q ++++++ R E ++ + + R ++ ++ L E+
Sbjct: 1630 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1678
Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
+LQ +EEA+ Q +V A ++ ALE +A E+ +
Sbjct: 1679 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1721
Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
E ++ + SL+ E +V +++ E + + + E E L LK
Sbjct: 1722 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1774
Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
+ E L RL Q E K L + KQ ++ + + G+
Sbjct: 1775 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816
Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
E + ++++ + Q++ +++ A +Q +L A QE + + +E E+ Q Q
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1867
Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
L E+EL + +A T + ELE+++ ++ L+ K + E ++ EK K+ LE
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1927
Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
E ++ +E R E K +L EE EA R AE +A
Sbjct: 1928 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1980
Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
E K +AE +E + + L +D + Q H A+ +E+L+ L K +
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
+E++ K + E L +K S A+ L++ I+
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 2089
Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
N + S+E E+ + ++ +E E + + ++ E R+ A+
Sbjct: 2090 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 2145
Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
EE LKA ++ R +E + +LA A Q E + + Q + T
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
Q + + RGE +E+A + A E +V + E+ S + +++
Sbjct: 2206 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2254
Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
+ E+ +A ++ + L + + + R A+ ++ + +D E +
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2314
Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
L +++ + T L TD N L++ +Q E A + + R
Sbjct: 2315 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2372
Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
+ E+ L A++ R + L+ + +++ QE E K Q+ E LS A
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2427
Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
L Q++ +EKM+ ++++ T+L+ E L Q K L + +A RL+
Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2487
Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
+ L +T E ++ R+L+ + E E+ KL R++ R +E+ + +
Sbjct: 2488 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2547
Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
E ++ L L Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++
Sbjct: 2548 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2605
Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
++ S + + LQ + QS L +D L + ++ +E++ +++ +L +
Sbjct: 2606 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2663
Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
++ + + + +QQME++RQ + + + +EA + ++ K E+LQ+ +++RQQ
Sbjct: 2664 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2720
Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
L E QRL+ +Q ++Q
Sbjct: 2721 EELLAEENQRLREQLQLLEEQ 2741
Score = 158 bits (399), Expect = 1e-37
Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)
Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
+PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ +
Sbjct: 1197 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1255
Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
L A+L++ R + + F L ++ +Q++ + QQ +
Sbjct: 1256 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1315
Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q
Sbjct: 1316 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1372
Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
+ +S +E++++++ ++EE+ +K E + + + + Q+V
Sbjct: 1373 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1428
Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
+++ + K + S +E L EL + +F ++ ++RME+E +R
Sbjct: 1429 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1487
Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
EQ RAE L E + Q Q ++E EE+ R + ++
Sbjct: 1488 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1547
Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
+ S + E+ +L + E+ K + + + +++EE+ ++ LE
Sbjct: 1548 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604
Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE
Sbjct: 1605 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1662
Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
+A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1720
Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + +
Sbjct: 1721 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1777
Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
+ + Q E+++ K L Q+ E +K+ E +E + +G EQ V+
Sbjct: 1778 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1822
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
+ +L + LEKQ + E Q++ A AE +++ L+ T +++R +
Sbjct: 1823 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1870
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
+ + + ++E ++ ++L+ + ++ E+ E+ R+T +++
Sbjct: 1871 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1924
Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
E ++EL EE A L + ++ E+ +Q E + KL A+ E
Sbjct: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1984
Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
L+ +K K + + ED+ F LE E + ++ E+L ++ K E
Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 2042
Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + +
Sbjct: 2043 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098
Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
+ + L+ + R + +V KS E + + K + E + + +E
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
L L+ Q + +LQ E + +Q + LQ Q+ +
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2212
Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
+DQ+R E + +A +E + A+ E + +++ + E +E
Sbjct: 2213 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2271
Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
KL+K +E + Q + L + + E + + E Q R
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2317
Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
+ Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+
Sbjct: 2318 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2370
Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430
Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
Q E ++ L++++QAV E+T L + + A+R +
Sbjct: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490
Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
+ + +E + LE + Q QLE + + +A E+SR
Sbjct: 2491 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2534
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
E A + A E+ + E+ + QT E + + + L + + E +
Sbjct: 2535 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2594
Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
E + + + + T+ +E ++ T ++QS E S + R + + +
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2652
Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q
Sbjct: 2653 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2712
Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
+ E L++E + L E+L+ L++ +LA E++ ++ NG +
Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2768
Score = 149 bits (376), Expect = 5e-35
Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)
Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
A E++ +R I E DI +LE C + + L + + RE R E KA+A
Sbjct: 1113 AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1168
Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
G +L E EK++ E A +R +L+ + LE QV +
Sbjct: 1169 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1222
Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
EK + + + Q E+ L + L E QA+ E + + ++KL Q + P
Sbjct: 1223 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1282
Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
F + + + R +++ L+++ ++ E+ +E++ + ++ + + + R RELEQ
Sbjct: 1283 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
L +++ D +A+ + Q+QA A + +E E+ L EE
Sbjct: 1342 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1394
Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
+E E+V++ K+ +++ E + +K +E + K+ S +
Sbjct: 1395 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1448
Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
+IQE +E T Q +K + E +R +E + E L Q
Sbjct: 1449 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1491
Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
+R R E+E +EK Q++LA + A ++E + Q +VV E+ A+
Sbjct: 1492 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1546
Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
+ Q + K ++E ++ Q ++ E+ + R+ E+ E+
Sbjct: 1547 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1582
Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
S+ + E E+ + L++ E Q +G + L R + E+ E +
Sbjct: 1583 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1635
Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
+Q++D Q + Q E E+ + + E++ A + +++L+A +E + + +
Sbjct: 1636 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1694
Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
+ + ++ + E EL S ++ + ++LE + E H ++ +E+ E +
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1754
Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
E E+ E ++ LE + K E +++S E K E G
Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1814
Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
E +A+R +A + EL ++ AE ++ L E + L+ + Q +E+
Sbjct: 1815 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1872
Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
L+ L++E Q E++ A + + + L+ ++ + S+S ++ Q L
Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1929
Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
AG L E + E + Q E+ Q A +L + I E LK E
Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1989
Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
+A LKE + E + LA +A+Q R +
Sbjct: 1990 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034
Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
+SDS + +G+ L F+ A+ G+ E +A D
Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094
Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
+ K + L A Q+ + E + E+ + ++ E +RKA + + LK
Sbjct: 2095 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2152
Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
+ + + RE +S++ + + + L A LQQ +E+SV
Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2212
Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
L A + E A + V L+Q +EQ + QAA
Sbjct: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272
Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
E L+K + QA A + ++ ++ +K +++ L Q +Q ++ ++++
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2331
Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
L + L E+L K E + +Q + EL +++ Q + L +L+A R+E +++
Sbjct: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2389
Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
+ ++T Q+++ +++ E+ E A+L + E D + L +
Sbjct: 2390 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2449
Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
+K + +Q LL+QQK+L E ++++ + QL+EE QG
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2509
Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
R LE+ E K+R+ EMS R E + + ++ G+ R L +++ +
Sbjct: 2510 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2569
Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
E+Q+Q E I EL E EK K + +QT QQ + ++ Q +
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2629
Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
++ +E+++ + ++ + + ++K+E L Q+ EE+++Q +++ E QRL M
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2689
Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
+E ++++ E EE ++ Q L +
Sbjct: 2690 EEARRRQHEAEEGVRRKQEELQQLEQ 2715
Score = 146 bits (369), Expect = 3e-34
Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)
Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++
Sbjct: 1360 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419
Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
QL ++ +E VI Y D +T L + I+ ++ +
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1479
Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
+ + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q +
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599
Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + +
Sbjct: 1600 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1653
Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
LA+ +K + + E K++ + ++E + E+ E R+R+ E + + V+ +T Q+
Sbjct: 1654 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709
Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
+ R F A+ E SL+ QL+ E + +++ E E+ E+ E
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
+ K E +L +Q E ++ + E E++ + + + + G A
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1816
Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
+E+ V +L EQ + Q+QL T + + + ELIR L ++
Sbjct: 1817 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1858
Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
E E++ + L E + +LQ+E A QK L E ++ +++V++A K
Sbjct: 1859 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1910
Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
E++ + +E+ K L+ + +L +E L+ E ++ + + E
Sbjct: 1911 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967
Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
AI ++ K E E+ L E + L+ L F + EE +
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027
Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
+E RL QL A D EL + ++D Q + ++++I+ L+ E+ A
Sbjct: 2028 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 2080
Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
+++L ++ A+ T+ S+ + L R+ +L ++ R E E +V
Sbjct: 2081 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 2128
Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
+ SL E+E K LE+ ++L K ++ RE+ ++ S + +++ +
Sbjct: 2129 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
+ + L+AE KA + ++K ++LQ+ L +++ + L+ +
Sbjct: 2181 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2223
Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
R EA+E E+E +V+E+++ + + + K +
Sbjct: 2224 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283
Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
+ + A ++ ++ E+ + Q +K + QEL + + ET+
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2337
Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
K LL EE LKA +++ S + E S Q E+ +
Sbjct: 2338 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2383
Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
I +E R + T F ++ ++ V E ++ + E
Sbjct: 2384 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2427
Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
++Q++E L +++A K L KMQ +EA + LL
Sbjct: 2428 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2471
Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
Q+ +E++ L + ++ + G LE Q Q +E A E L+ R +
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2528
Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
+S QA A+ + ++ + E+ EK + E Q+K + + ++++ A L
Sbjct: 2529 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2585
Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
+E +AEL+ E + KL+ E L LK E ++ + E L +
Sbjct: 2586 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2632
Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
SE+ + + +E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2685
Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
S + E++R ++A+ +E+ + LE Q LL E R+RE L+ +
Sbjct: 2686 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743
Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
H++ ++ ++ D L + E +HS
Sbjct: 2744 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2782
Score = 142 bits (359), Expect = 5e-33
Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)
Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
DI ++E R + +LR LD+ ++ Q + Q AQ E+E +
Sbjct: 1128 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1175
Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
+ ++ +++ + + A L +L+ T + E+++ + LE+ + R
Sbjct: 1176 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1235
Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
+ E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E
Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1295
Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
+ L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E
Sbjct: 1296 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1354
Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
+ L++ + +I L D+ + + +Q L E+ +K+E Q F K +
Sbjct: 1355 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1414
Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
++ + ++ L+ +K ++ + +E LR E TL + +
Sbjct: 1415 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1474
Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
E + E E+ +++ + +E+ A++EA L+ +++ E + +E +
Sbjct: 1475 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1528
Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
++ + ++ V +E E D +QQ + EE+++ R + +E + ++ +
Sbjct: 1529 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1578
Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
L++++++ + + E + + A E LQ + + + A
Sbjct: 1579 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1624
Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
+ + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+
Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1680
Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
+ E+ R R+ E+ RA VQ + R AE + SF E+
Sbjct: 1681 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1725
Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
+ + E S QE+ + + + +E+ RA Q +E ++ ++E +E
Sbjct: 1726 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1765
Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
+ R Q++A + + V Q + + E +K +EE +E ++
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1814
Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
+ E Q ++ +E ++ K L G Q+ ++ E L+ E
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1860
Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
+++ + E E LQ ++ + L KV E LL SK +
Sbjct: 1861 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1912
Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
+ E ++ L E F + + L + K + + L + Q E
Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1968
Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
E +++ + E T EAEI +K RL+ ++E ++ ++D
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028
Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
+ + + ++K D +E + G+ E+T + + Q+EEE+ + S A A
Sbjct: 2029 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 2076
Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
+ EL RI E+T SK Q ++E+ E
Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136
Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
Q + + E + K +E + + E +++ L+ E K +
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2196
Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
++ +T QS+ D++ + A R ++ E + RQ E ++Q
Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256
Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
E Q QA ++ ++ E + + Q E L ++ A + ++ +E R
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316
Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
++ +E EL L+ QL +K L EL+ + + +VEE+ F + +
Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
+ I + R + + + + L E + V E R S +Q +A
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2429
Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
L +E + + + + E+ + +++ + + +++ ++ EL+Q R
Sbjct: 2430 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2481
Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
+ + E++ ++ Q ++ LEA E S++ E K+ E+ R R
Sbjct: 2482 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2535
Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
+++A K EE+ E+LH A ++ + E Q Q+
Sbjct: 2536 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2581
Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
+RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L +
Sbjct: 2582 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2631
Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+
Sbjct: 2632 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2727
Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
+ E L E+ R +EE+ + + + T D A EA
Sbjct: 2728 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2777
Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
+PE S + L+ + A +E I + EE
Sbjct: 2778 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2805
Score = 140 bits (353), Expect = 2e-32
Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)
Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
QE +LE L ++ Q V MK L Q + + ++ +RS+S T
Sbjct: 1003 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 1051
Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
+ + A++ L + Q + + G E++ +R+ S +Q
Sbjct: 1052 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 1104
Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
+ ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L +
Sbjct: 1105 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1149
Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
++ R+AE Q +AE+E L + L + E++ L E + E L
Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1206
Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
+ +Q+ L +K++T+ + L +LK+ Q
Sbjct: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1266
Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
+ +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++
Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1326
Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
+ A+ + + E + L L+ + S + +L + + +++I+ + + +++
Sbjct: 1327 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1379
Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
+++Q Q L EEIE+ ++ + +++ L+ K LE + +
Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1438
Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+
Sbjct: 1439 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1492
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
+RE+L + + QL + H + E E K L+Q ++ +R RE + +
Sbjct: 1493 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1551
Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
++Q Q+ + + +R AE + E S++ +E+++ + +
Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1602
Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
+Q L +LRA +E + QK ++E+ ++Q E+QR + V
Sbjct: 1603 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654
Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
+ EK +AL +L+E + A+E + + E+++ Q+++ Q + +
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1712
Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
+LQ + Q S+ E+ A E + + E+ E
Sbjct: 1713 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1765
Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
+ R++++ + L + + L + K ++ + + E+ + + E
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1825
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
+ Q E + +L++ Q+L + + E + E + + L+++L ++
Sbjct: 1826 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1880
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
A QKR + +E + + V+ S A+ S +K+ +G F
Sbjct: 1881 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1934
Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
+ EE ++ L E + Q QL EE A + A A++ +++ E T +A
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1990
Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
++++ ++ + FQ + L ++ +H DI
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 2028
Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
E + S+ + K + +RQ E + ++ AS + + ++ +
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088
Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
R A + LR ++E R+ Q +EE +R + + S+ E + + +
Sbjct: 2089 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143
Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
LEE+E LK R + S+ Q Q E Q E + F KE+EL
Sbjct: 2144 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203
Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
+ + E + L E R A ++A ++ E ++ VEE L +S
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2257
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
++ Q+ A ++ AE K E R E ++ +D +++ T +
Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317
Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
++ Q L E D + + L+ RL+A + S+ +L +V E
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436
Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
+ ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL +
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496
Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
ET+ + +LE+ +AE+++ +D Q+ K E ++ E++
Sbjct: 2497 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2555
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK
Sbjct: 2556 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2609
Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
E QT + EQL ++T + LS++ + +R IE+ + ++ +
Sbjct: 2610 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2655
Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
L Q + A ++ + R+ + + L S+E + + +A + RK++E+ LE+
Sbjct: 2656 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2715
Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Q Q E L +N+ +++ LE Q + + +E+
Sbjct: 2716 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752
Score = 122 bits (306), Expect = 7e-27
Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)
Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
A E ++ + + QAE + + K + L + E+ L + L +LE+
Sbjct: 1153 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1206
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
+ +L+++ + ++ + ++ + L I+ + A H K AQ + E++
Sbjct: 1207 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1264
Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
+ KL+ Q + + + +R + E L R+ E+E+ E +
Sbjct: 1265 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1318
Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
+L + + +T + L + L++ + A+ L A Q E++ M
Sbjct: 1319 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1374
Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
L ++ QL QE L ++R E VE+ Q + +N D+ EL++V +
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1428
Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
L+ + + K ++G S+I +L T +L + S +++ +++++ +
Sbjct: 1429 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1487
Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
+ Q++ +++ E V AAL Q QL AK +E E +Q
Sbjct: 1488 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1532
Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
Q +R +E D I E Q+ + + I K Q E AE++ L E+++
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592
Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
++ LE E+++ G EL+ALRA + +A+
Sbjct: 1593 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1625
Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
+E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q +
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685
Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
++ ++ Q L+ + + ++ K A + Q E S +E ++
Sbjct: 1686 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1741
Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
Q E+ E+ + A AE E+ E LK + ++L EE K++ Q K
Sbjct: 1742 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1801
Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
+ A A + RE+ + +EG ++ +A
Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1848
Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
+ LRA +G Q L E + + + +Q E L + +A +
Sbjct: 1849 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1903
Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
+ + K K + + EAE + E + R A +Q L E
Sbjct: 1904 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1963
Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
E A+G L+ + E +A E L++ A +R L E A
Sbjct: 1964 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 2023
Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K S
Sbjct: 2024 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 2070
Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
EK AEL+ EL + + E TL++ K ELEA R A E
Sbjct: 2071 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 2116
Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
+++ RE + ++K A + R + EE+E LK +E ++ + +Q QL
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176
Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
E+ QK E + + Q E+ ELQ L+ E+ + ++ + R
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231
Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Q
Sbjct: 2232 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2291
Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
+ +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL+
Sbjct: 2292 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2351
Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
E +Q + EE+ S R+ + L++ L+ +IE E + L
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2391
Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
I + T L+ +K++ VA + L A E + +ED + Q + E +
Sbjct: 2392 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2448
Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
L+ E+ V +T + E LL+Q EL ++ +E D M +L E
Sbjct: 2449 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2496
Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
+ + +++T L + +++E E + ++ RAE A+ ++
Sbjct: 2497 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545
Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
+AE + L +T E VTL
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTL 2567
Score = 48.5 bits (114), Expect = 1e-04
Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)
Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
LL LEQ QE+ C + +SE++ + Q+ R + R ++
Sbjct: 1105 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1151
Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
P++E + +Q+++Q E+ + L + +EK++ S A T + EL
Sbjct: 1152 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1204
Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
E TL + + ++ L A LE K KT + + A E ++ E Q +
Sbjct: 1205 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1262
Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
E K L+ L+ E+Q+ L L +++ QQ+ +R + + E +
Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1321
Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
LE Q +L VR RE+ L RE L A LQ + + +P D +
Sbjct: 1322 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1380
Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
+++QL ++ + + E+ EK + +Q + KD ++ T + + E KK
Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440
Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
++QS E + ++ + R +L L Q ++ I + ++ E E + R + L
Sbjct: 1441 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499
Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
E +L R + + + + + AK ++ E + +Q+ + +
Sbjct: 1500 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555
Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
+LQ L Q + +Q + A + + ++E I + LQL+ Q+G +
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615
Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
+ E RQ E + Q+ +E R ++L +++ + A R+
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1673
Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
++A A +E E + ++ L+ + + AEAE+ +A + S
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
EHV + + LR E+ R+A
Sbjct: 1734 QEEHVAVAQ-----LREEAERRA 1751
Score = 35.8 bits (81), Expect = 0.86
Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)
Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
+E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A
Sbjct: 2477 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2536
Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
D + Q E+ R E + T+++TL + + H+ E +E+
Sbjct: 2537 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2595
Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
+ E K L EE V Q Q + L ++
Sbjct: 2596 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2645
Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
IE+ +LE++ + Q +E + +Q + +L A++++ARR + E
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2705
Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H
Sbjct: 2706 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2742
Score = 35.0 bits (79), Expect = 1.5
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
+QLN+ LQ +++ KV + E+ RDL ++ I L +D + +K R + EQ
Sbjct: 547 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 606
Query: 2352 LNEVIEKLQQELANI 2366
+ + +L + L I
Sbjct: 607 MYRRVYRLHERLVAI 621
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 191 bits (486), Expect = 9e-48
Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)
Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
+++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ +
Sbjct: 1378 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1437
Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
QL QR + E + R EE EA K+ + E+L ++++ S Q +
Sbjct: 1438 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1491
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
+ E+ + E E R+ + + L R ++A RL + +E + ET
Sbjct: 1492 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1548
Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
RS++++ + +E A ++ + EEH V
Sbjct: 1549 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1581
Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
+++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E
Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641
Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
K E RE+ R+ + ++++ +E + L ++ + E A + AE +
Sbjct: 1642 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1698
Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
E E+Q Q + + RL++E A+ + QELEAE +++ E E+L
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758
Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
+ K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++
Sbjct: 1759 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
+ E + K + L+++ E + E++R+ +++A R + Q +E++L
Sbjct: 1818 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873
Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Q R+ + L+ + + L + Q++ +I EK
Sbjct: 1874 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
ELE L + DT + E +A+ E + + QL AE R+A +R +K +
Sbjct: 1921 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1972
Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
EE Q + L EEV++L ++E ++ QE ++ +L ++ +K A
Sbjct: 1973 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
+++ A + Q + + Q +Q+++ +DQL + ++Q + +
Sbjct: 2029 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085
Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
+ +EE L + E Q + Q ++ R+E + E + Q E A + QK + +
Sbjct: 2086 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2142
Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
A E + K + + +K +EQ E+T ++ L+ET+ + N L +EL L
Sbjct: 2143 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2190
Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
K E + +S E SV V ++ LSK K +E L+ +N F EE
Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2249
Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
K + E L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K
Sbjct: 2250 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2304
Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
A L+ Q Q E QE A+ Q+++ ++ Q + R+ E+ ++ L
Sbjct: 2305 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363
Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
LR++E+ E ++H + + +E+V + + +++++ +
Sbjct: 2364 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2423
Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
++L E + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L
Sbjct: 2424 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2481
Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
K K E+L ++ + K + Q+ + Q R L + E+ + E E
Sbjct: 2482 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541
Query: 2756 TEVQESKK 2763
V+ ++
Sbjct: 2542 EGVRRKQE 2549
Score = 167 bits (424), Expect = 1e-40
Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)
Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
PE + S L+ + KL + S ++ LE K + R Q A E L+
Sbjct: 1032 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1086
Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
EE + +E AV + E + +K + + Q+ T D L EL A
Sbjct: 1087 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1134
Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R
Sbjct: 1135 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1191
Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
+ L+ D + + + + + + +Q QAL +++E+ + ++E Q
Sbjct: 1192 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1250
Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
+++ + E+Q + + QL+ V P+ Q SE +E L H E T S+
Sbjct: 1251 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1310
Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
I+ +E + ++E R EQ Q+ E+R+ VEA
Sbjct: 1311 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1351
Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
E + + QAER+A + R ++E+ EE +++ + EE+QQL E +
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1411
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
+ + + E+ ++++ + L ++ ++ + L A+ +E E + Q
Sbjct: 1412 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1470
Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
E+ +L++Q ++++++ R E ++ + + R ++ ++ L E+
Sbjct: 1471 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1519
Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
+LQ +EEA+ Q +V A ++ ALE +A E+ +
Sbjct: 1520 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1562
Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
E ++ + SL+ E +V +++ E + + + E E L LK
Sbjct: 1563 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1615
Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
+ E L RL Q E K L + KQ ++ + + G+
Sbjct: 1616 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1657
Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
E + ++++ + Q++ +++ A +Q +L A QE + + +E E+ Q Q
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1708
Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
L E+EL + +A T + ELE+++ ++ L+ K + E ++ EK K+ LE
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1768
Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
E ++ +E R E K +L EE EA R AE +A
Sbjct: 1769 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1821
Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
E K +AE +E + + L +D + Q H A+ +E+L+ L K +
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
+E++ K + E L +K S A+ L++ I+
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1930
Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
N + S+E E+ + ++ +E E + + ++ E R+ A+
Sbjct: 1931 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 1986
Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
EE LKA ++ R +E + +LA A Q E + + Q + T
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
Q + + RGE +E+A + A E +V + E+ S + +++
Sbjct: 2047 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2095
Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
+ E+ +A ++ + L + + + R A+ ++ + +D E +
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2155
Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
L +++ + T L TD N L++ +Q E A + + R
Sbjct: 2156 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2213
Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
+ E+ L A++ R + L+ + +++ QE E K Q+ E LS A
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2268
Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
L Q++ +EKM+ ++++ T+L+ E L Q K L + +A RL+
Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2328
Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
+ L +T E ++ R+L+ + E E+ KL R++ R +E+ + +
Sbjct: 2329 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2388
Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
E ++ L L Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++
Sbjct: 2389 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2446
Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
++ S + + LQ + QS L +D L + ++ +E++ +++ +L +
Sbjct: 2447 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2504
Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
++ + + + +QQME++RQ + + + +EA + ++ K E+LQ+ +++RQQ
Sbjct: 2505 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2561
Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
L E QRL+ +Q ++Q
Sbjct: 2562 EELLAEENQRLREQLQLLEEQ 2582
Score = 158 bits (399), Expect = 1e-37
Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)
Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
+PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ +
Sbjct: 1038 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1096
Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
L A+L++ R + + F L ++ +Q++ + QQ +
Sbjct: 1097 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1156
Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q
Sbjct: 1157 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1213
Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
+ +S +E++++++ ++EE+ +K E + + + + Q+V
Sbjct: 1214 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1269
Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
+++ + K + S +E L EL + +F ++ ++RME+E +R
Sbjct: 1270 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1328
Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
EQ RAE L E + Q Q ++E EE+ R + ++
Sbjct: 1329 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1388
Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
+ S + E+ +L + E+ K + + + +++EE+ ++ LE
Sbjct: 1389 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1445
Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE
Sbjct: 1446 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1503
Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
+A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1561
Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + +
Sbjct: 1562 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1618
Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
+ + Q E+++ K L Q+ E +K+ E +E + +G EQ V+
Sbjct: 1619 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1663
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
+ +L + LEKQ + E Q++ A AE +++ L+ T +++R +
Sbjct: 1664 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1711
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
+ + + ++E ++ ++L+ + ++ E+ E+ R+T +++
Sbjct: 1712 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1765
Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
E ++EL EE A L + ++ E+ +Q E + KL A+ E
Sbjct: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1825
Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
L+ +K K + + ED+ F LE E + ++ E+L ++ K E
Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1883
Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + +
Sbjct: 1884 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939
Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
+ + L+ + R + +V KS E + + K + E + + +E
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
L L+ Q + +LQ E + +Q + LQ Q+ +
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2053
Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
+DQ+R E + +A +E + A+ E + +++ + E +E
Sbjct: 2054 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2112
Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
KL+K +E + Q + L + + E + + E Q R
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2158
Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
+ Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+
Sbjct: 2159 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2211
Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271
Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
Q E ++ L++++QAV E+T L + + A+R +
Sbjct: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331
Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
+ + +E + LE + Q QLE + + +A E+SR
Sbjct: 2332 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2375
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
E A + A E+ + E+ + QT E + + + L + + E +
Sbjct: 2376 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2435
Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
E + + + + T+ +E ++ T ++QS E S + R + + +
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2493
Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q
Sbjct: 2494 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2553
Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
+ E L++E + L E+L+ L++ +LA E++ ++ NG +
Sbjct: 2554 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2609
Score = 149 bits (376), Expect = 5e-35
Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)
Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
A E++ +R I E DI +LE C + + L + + RE R E KA+A
Sbjct: 954 AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1009
Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
G +L E EK++ E A +R +L+ + LE QV +
Sbjct: 1010 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1063
Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
EK + + + Q E+ L + L E QA+ E + + ++KL Q + P
Sbjct: 1064 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1123
Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
F + + + R +++ L+++ ++ E+ +E++ + ++ + + + R RELEQ
Sbjct: 1124 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182
Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
L +++ D +A+ + Q+QA A + +E E+ L EE
Sbjct: 1183 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1235
Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
+E E+V++ K+ +++ E + +K +E + K+ S +
Sbjct: 1236 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1289
Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
+IQE +E T Q +K + E +R +E + E L Q
Sbjct: 1290 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1332
Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
+R R E+E +EK Q++LA + A ++E + Q +VV E+ A+
Sbjct: 1333 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1387
Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
+ Q + K ++E ++ Q ++ E+ + R+ E+ E+
Sbjct: 1388 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1423
Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
S+ + E E+ + L++ E Q +G + L R + E+ E +
Sbjct: 1424 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1476
Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
+Q++D Q + Q E E+ + + E++ A + +++L+A +E + + +
Sbjct: 1477 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1535
Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
+ + ++ + E EL S ++ + ++LE + E H ++ +E+ E +
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1595
Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
E E+ E ++ LE + K E +++S E K E G
Sbjct: 1596 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1655
Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
E +A+R +A + EL ++ AE ++ L E + L+ + Q +E+
Sbjct: 1656 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1713
Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
L+ L++E Q E++ A + + + L+ ++ + S+S ++ Q L
Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1770
Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
AG L E + E + Q E+ Q A +L + I E LK E
Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1830
Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
+A LKE + E + LA +A+Q R +
Sbjct: 1831 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875
Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
+SDS + +G+ L F+ A+ G+ E +A D
Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935
Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
+ K + L A Q+ + E + E+ + ++ E +RKA + + LK
Sbjct: 1936 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1993
Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
+ + + RE +S++ + + + L A LQQ +E+SV
Sbjct: 1994 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2053
Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
L A + E A + V L+Q +EQ + QAA
Sbjct: 2054 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2113
Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
E L+K + QA A + ++ ++ +K +++ L Q +Q ++ ++++
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2172
Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
L + L E+L K E + +Q + EL +++ Q + L +L+A R+E +++
Sbjct: 2173 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2230
Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
+ ++T Q+++ +++ E+ E A+L + E D + L +
Sbjct: 2231 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2290
Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
+K + +Q LL+QQK+L E ++++ + QL+EE QG
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2350
Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
R LE+ E K+R+ EMS R E + + ++ G+ R L +++ +
Sbjct: 2351 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2410
Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
E+Q+Q E I EL E EK K + +QT QQ + ++ Q +
Sbjct: 2411 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2470
Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
++ +E+++ + ++ + + ++K+E L Q+ EE+++Q +++ E QRL M
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2530
Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
+E ++++ E EE ++ Q L +
Sbjct: 2531 EEARRRQHEAEEGVRRKQEELQQLEQ 2556
Score = 146 bits (369), Expect = 3e-34
Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)
Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++
Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260
Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
QL ++ +E VI Y D +T L + I+ ++ +
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320
Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
+ + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q +
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440
Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + +
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1494
Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
LA+ +K + + E K++ + ++E + E+ E R+R+ E + + V+ +T Q+
Sbjct: 1495 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550
Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
+ R F A+ E SL+ QL+ E + +++ E E+ E+ E
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610
Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
+ K E +L +Q E ++ + E E++ + + + + G A
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1657
Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
+E+ V +L EQ + Q+QL T + + + ELIR L ++
Sbjct: 1658 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1699
Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
E E++ + L E + +LQ+E A QK L E ++ +++V++A K
Sbjct: 1700 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1751
Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
E++ + +E+ K L+ + +L +E L+ E ++ + + E
Sbjct: 1752 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808
Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
AI ++ K E E+ L E + L+ L F + EE +
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1868
Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
+E RL QL A D EL + ++D Q + ++++I+ L+ E+ A
Sbjct: 1869 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1921
Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
+++L ++ A+ T+ S+ + L R+ +L ++ R E E +V
Sbjct: 1922 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1969
Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
+ SL E+E K LE+ ++L K ++ RE+ ++ S + +++ +
Sbjct: 1970 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2021
Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
+ + L+AE KA + ++K ++LQ+ L +++ + L+ +
Sbjct: 2022 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2064
Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
R EA+E E+E +V+E+++ + + + K +
Sbjct: 2065 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
+ + A ++ ++ E+ + Q +K + QEL + + ET+
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2178
Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
K LL EE LKA +++ S + E S Q E+ +
Sbjct: 2179 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2224
Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
I +E R + T F ++ ++ V E ++ + E
Sbjct: 2225 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2268
Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
++Q++E L +++A K L KMQ +EA + LL
Sbjct: 2269 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2312
Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
Q+ +E++ L + ++ + G LE Q Q +E A E L+ R +
Sbjct: 2313 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2369
Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
+S QA A+ + ++ + E+ EK + E Q+K + + ++++ A L
Sbjct: 2370 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2426
Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
+E +AEL+ E + KL+ E L LK E ++ + E L +
Sbjct: 2427 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2473
Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
SE+ + + +E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2526
Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
S + E++R ++A+ +E+ + LE Q LL E R+RE L+ +
Sbjct: 2527 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2584
Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
H++ ++ ++ D L + E +HS
Sbjct: 2585 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2623
Score = 142 bits (359), Expect = 5e-33
Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)
Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
DI ++E R + +LR LD+ ++ Q + Q AQ E+E +
Sbjct: 969 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1016
Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
+ ++ +++ + + A L +L+ T + E+++ + LE+ + R
Sbjct: 1017 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1076
Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
+ E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E
Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1136
Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
+ L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E
Sbjct: 1137 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1195
Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
+ L++ + +I L D+ + + +Q L E+ +K+E Q F K +
Sbjct: 1196 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1255
Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
++ + ++ L+ +K ++ + +E LR E TL + +
Sbjct: 1256 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1315
Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
E + E E+ +++ + +E+ A++EA L+ +++ E + +E +
Sbjct: 1316 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1369
Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
++ + ++ V +E E D +QQ + EE+++ R + +E + ++ +
Sbjct: 1370 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1419
Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
L++++++ + + E + + A E LQ + + + A
Sbjct: 1420 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1465
Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
+ + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+
Sbjct: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1521
Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
+ E+ R R+ E+ RA VQ + R AE + SF E+
Sbjct: 1522 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1566
Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
+ + E S QE+ + + + +E+ RA Q +E ++ ++E +E
Sbjct: 1567 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1606
Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
+ R Q++A + + V Q + + E +K +EE +E ++
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1655
Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
+ E Q ++ +E ++ K L G Q+ ++ E L+ E
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1701
Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
+++ + E E LQ ++ + L KV E LL SK +
Sbjct: 1702 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1753
Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
+ E ++ L E F + + L + K + + L + Q E
Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1809
Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
E +++ + E T EAEI +K RL+ ++E ++ ++D
Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1869
Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
+ + + ++K D +E + G+ E+T + + Q+EEE+ + S A A
Sbjct: 1870 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1917
Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
+ EL RI E+T SK Q ++E+ E
Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977
Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
Q + + E + K +E + + E +++ L+ E K +
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2037
Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
++ +T QS+ D++ + A R ++ E + RQ E ++Q
Sbjct: 2038 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2097
Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
E Q QA ++ ++ E + + Q E L ++ A + ++ +E R
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2157
Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
++ +E EL L+ QL +K L EL+ + + +VEE+ F + +
Sbjct: 2158 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
+ I + R + + + + L E + V E R S +Q +A
Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2270
Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
L +E + + + + E+ + +++ + + +++ ++ EL+Q R
Sbjct: 2271 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2322
Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
+ + E++ ++ Q ++ LEA E S++ E K+ E+ R R
Sbjct: 2323 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2376
Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
+++A K EE+ E+LH A ++ + E Q Q+
Sbjct: 2377 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2422
Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
+RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L +
Sbjct: 2423 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2472
Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+
Sbjct: 2473 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2568
Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
+ E L E+ R +EE+ + + + T D A EA
Sbjct: 2569 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2618
Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
+PE S + L+ + A +E I + EE
Sbjct: 2619 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2646
Score = 140 bits (353), Expect = 2e-32
Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)
Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
QE +LE L ++ Q V MK L Q + + ++ +RS+S T
Sbjct: 844 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 892
Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
+ + A++ L + Q + + G E++ +R+ S +Q
Sbjct: 893 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 945
Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
+ ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L +
Sbjct: 946 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 990
Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
++ R+AE Q +AE+E L + L + E++ L E + E L
Sbjct: 991 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1047
Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
+ +Q+ L +K++T+ + L +LK+ Q
Sbjct: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1107
Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
+ +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++
Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167
Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
+ A+ + + E + L L+ + S + +L + + +++I+ + + +++
Sbjct: 1168 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1220
Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
+++Q Q L EEIE+ ++ + +++ L+ K LE + +
Sbjct: 1221 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1279
Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+
Sbjct: 1280 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1333
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
+RE+L + + QL + H + E E K L+Q ++ +R RE + +
Sbjct: 1334 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1392
Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
++Q Q+ + + +R AE + E S++ +E+++ + +
Sbjct: 1393 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1443
Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
+Q L +LRA +E + QK ++E+ ++Q E+QR + V
Sbjct: 1444 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
+ EK +AL +L+E + A+E + + E+++ Q+++ Q + +
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1553
Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
+LQ + Q S+ E+ A E + + E+ E
Sbjct: 1554 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606
Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
+ R++++ + L + + L + K ++ + + E+ + + E
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1666
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
+ Q E + +L++ Q+L + + E + E + + L+++L ++
Sbjct: 1667 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1721
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
A QKR + +E + + V+ S A+ S +K+ +G F
Sbjct: 1722 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1775
Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
+ EE ++ L E + Q QL EE A + A A++ +++ E T +A
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1831
Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
++++ ++ + FQ + L ++ +H DI
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1869
Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
E + S+ + K + +RQ E + ++ AS + + ++ +
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929
Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
R A + LR ++E R+ Q +EE +R + + S+ E + + +
Sbjct: 1930 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984
Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
LEE+E LK R + S+ Q Q E Q E + F KE+EL
Sbjct: 1985 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044
Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
+ + E + L E R A ++A ++ E ++ VEE L +S
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2098
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
++ Q+ A ++ AE K E R E ++ +D +++ T +
Sbjct: 2099 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158
Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
++ Q L E D + + L+ RL+A + S+ +L +V E
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E
Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277
Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
+ ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL +
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337
Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
ET+ + +LE+ +AE+++ +D Q+ K E ++ E++
Sbjct: 2338 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2396
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK
Sbjct: 2397 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2450
Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
E QT + EQL ++T + LS++ + +R IE+ + ++ +
Sbjct: 2451 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2496
Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
L Q + A ++ + R+ + + L S+E + + +A + RK++E+ LE+
Sbjct: 2497 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2556
Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Q Q E L +N+ +++ LE Q + + +E+
Sbjct: 2557 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593
Score = 122 bits (306), Expect = 7e-27
Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)
Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
A E ++ + + QAE + + K + L + E+ L + L +LE+
Sbjct: 994 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1047
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
+ +L+++ + ++ + ++ + L I+ + A H K AQ + E++
Sbjct: 1048 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1105
Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
+ KL+ Q + + + +R + E L R+ E+E+ E +
Sbjct: 1106 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1159
Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
+L + + +T + L + L++ + A+ L A Q E++ M
Sbjct: 1160 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1215
Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
L ++ QL QE L ++R E VE+ Q + +N D+ EL++V +
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1269
Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
L+ + + K ++G S+I +L T +L + S +++ +++++ +
Sbjct: 1270 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1328
Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
+ Q++ +++ E V AAL Q QL AK +E E +Q
Sbjct: 1329 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1373
Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
Q +R +E D I E Q+ + + I K Q E AE++ L E+++
Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433
Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
++ LE E+++ G EL+ALRA + +A+
Sbjct: 1434 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1466
Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
+E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q +
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526
Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
++ ++ Q L+ + + ++ K A + Q E S +E ++
Sbjct: 1527 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1582
Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
Q E+ E+ + A AE E+ E LK + ++L EE K++ Q K
Sbjct: 1583 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1642
Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
+ A A + RE+ + +EG ++ +A
Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1689
Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
+ LRA +G Q L E + + + +Q E L + +A +
Sbjct: 1690 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1744
Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
+ + K K + + EAE + E + R A +Q L E
Sbjct: 1745 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1804
Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
E A+G L+ + E +A E L++ A +R L E A
Sbjct: 1805 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1864
Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K S
Sbjct: 1865 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1911
Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
EK AEL+ EL + + E TL++ K ELEA R A E
Sbjct: 1912 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1957
Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
+++ RE + ++K A + R + EE+E LK +E ++ + +Q QL
Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2017
Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
E+ QK E + + Q E+ ELQ L+ E+ + ++ + R
Sbjct: 2018 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Q
Sbjct: 2073 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2132
Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
+ +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL+
Sbjct: 2133 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2192
Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
E +Q + EE+ S R+ + L++ L+ +IE E + L
Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2232
Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
I + T L+ +K++ VA + L A E + +ED + Q + E +
Sbjct: 2233 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2289
Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
L+ E+ V +T + E LL+Q EL ++ +E D M +L E
Sbjct: 2290 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2337
Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
+ + +++T L + +++E E + ++ RAE A+ ++
Sbjct: 2338 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386
Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
+AE + L +T E VTL
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTL 2408
Score = 48.5 bits (114), Expect = 1e-04
Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)
Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
LL LEQ QE+ C + +SE++ + Q+ R + R ++
Sbjct: 946 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 992
Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
P++E + +Q+++Q E+ + L + +EK++ S A T + EL
Sbjct: 993 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1045
Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
E TL + + ++ L A LE K KT + + A E ++ E Q +
Sbjct: 1046 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1103
Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
E K L+ L+ E+Q+ L L +++ QQ+ +R + + E +
Sbjct: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1162
Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
LE Q +L VR RE+ L RE L A LQ + + +P D +
Sbjct: 1163 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1221
Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
+++QL ++ + + E+ EK + +Q + KD ++ T + + E KK
Sbjct: 1222 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1281
Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
++QS E + ++ + R +L L Q ++ I + ++ E E + R + L
Sbjct: 1282 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340
Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
E +L R + + + + + AK ++ E + +Q+ + +
Sbjct: 1341 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1396
Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
+LQ L Q + +Q + A + + ++E I + LQL+ Q+G +
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456
Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
+ E RQ E + Q+ +E R ++L +++ + A R+
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1514
Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
++A A +E E + ++ L+ + + AEAE+ +A + S
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
EHV + + LR E+ R+A
Sbjct: 1575 QEEHVAVAQ-----LREEAERRA 1592
Score = 35.8 bits (81), Expect = 0.86
Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)
Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
+E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A
Sbjct: 2318 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2377
Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
D + Q E+ R E + T+++TL + + H+ E +E+
Sbjct: 2378 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2436
Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
+ E K L EE V Q Q + L ++
Sbjct: 2437 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2486
Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
IE+ +LE++ + Q +E + +Q + +L A++++ARR + E
Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2546
Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H
Sbjct: 2547 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2583
Score = 35.0 bits (79), Expect = 1.5
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
+QLN+ LQ +++ KV + E+ RDL ++ I L +D + +K R + EQ
Sbjct: 388 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 447
Query: 2352 LNEVIEKLQQELANI 2366
+ + +L + L I
Sbjct: 448 MYRRVYRLHERLVAI 462
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 191 bits (486), Expect = 9e-48
Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)
Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
+++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ +
Sbjct: 1386 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1445
Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
QL QR + E + R EE EA K+ + E+L ++++ S Q +
Sbjct: 1446 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1499
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
+ E+ + E E R+ + + L R ++A RL + +E + ET
Sbjct: 1500 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1556
Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
RS++++ + +E A ++ + EEH V
Sbjct: 1557 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1589
Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
+++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E
Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649
Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
K E RE+ R+ + ++++ +E + L ++ + E A + AE +
Sbjct: 1650 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1706
Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
E E+Q Q + + RL++E A+ + QELEAE +++ E E+L
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766
Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
+ K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++
Sbjct: 1767 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825
Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
+ E + K + L+++ E + E++R+ +++A R + Q +E++L
Sbjct: 1826 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881
Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Q R+ + L+ + + L + Q++ +I EK
Sbjct: 1882 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
ELE L + DT + E +A+ E + + QL AE R+A +R +K +
Sbjct: 1929 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 1980
Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
EE Q + L EEV++L ++E ++ QE ++ +L ++ +K A
Sbjct: 1981 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036
Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
+++ A + Q + + Q +Q+++ +DQL + ++Q + +
Sbjct: 2037 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093
Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
+ +EE L + E Q + Q ++ R+E + E + Q E A + QK + +
Sbjct: 2094 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2150
Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
A E + K + + +K +EQ E+T ++ L+ET+ + N L +EL L
Sbjct: 2151 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2198
Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
K E + +S E SV V ++ LSK K +E L+ +N F EE
Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2257
Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
K + E L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K
Sbjct: 2258 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2312
Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
A L+ Q Q E QE A+ Q+++ ++ Q + R+ E+ ++ L
Sbjct: 2313 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371
Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
LR++E+ E ++H + + +E+V + + +++++ +
Sbjct: 2372 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2431
Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
++L E + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L
Sbjct: 2432 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2489
Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
K K E+L ++ + K + Q+ + Q R L + E+ + E E
Sbjct: 2490 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2549
Query: 2756 TEVQESKK 2763
V+ ++
Sbjct: 2550 EGVRRKQE 2557
Score = 167 bits (424), Expect = 1e-40
Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)
Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
PE + S L+ + KL + S ++ LE K + R Q A E L+
Sbjct: 1040 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1094
Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
EE + +E AV + E + +K + + Q+ T D L EL A
Sbjct: 1095 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1142
Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R
Sbjct: 1143 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1199
Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
+ L+ D + + + + + + +Q QAL +++E+ + ++E Q
Sbjct: 1200 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1258
Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
+++ + E+Q + + QL+ V P+ Q SE +E L H E T S+
Sbjct: 1259 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1318
Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
I+ +E + ++E R EQ Q+ E+R+ VEA
Sbjct: 1319 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1359
Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
E + + QAER+A + R ++E+ EE +++ + EE+QQL E +
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1419
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
+ + + E+ ++++ + L ++ ++ + L A+ +E E + Q
Sbjct: 1420 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1478
Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
E+ +L++Q ++++++ R E ++ + + R ++ ++ L E+
Sbjct: 1479 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1527
Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
+LQ +EEA+ Q +V A ++ ALE +A E+ +
Sbjct: 1528 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1570
Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
E ++ + SL+ E +V +++ E + + + E E L LK
Sbjct: 1571 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1623
Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
+ E L RL Q E K L + KQ ++ + + G+
Sbjct: 1624 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1665
Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
E + ++++ + Q++ +++ A +Q +L A QE + + +E E+ Q Q
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1716
Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
L E+EL + +A T + ELE+++ ++ L+ K + E ++ EK K+ LE
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1776
Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
E ++ +E R E K +L EE EA R AE +A
Sbjct: 1777 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1829
Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
E K +AE +E + + L +D + Q H A+ +E+L+ L K +
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889
Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
+E++ K + E L +K S A+ L++ I+
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1938
Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
N + S+E E+ + ++ +E E + + ++ E R+ A+
Sbjct: 1939 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 1994
Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
EE LKA ++ R +E + +LA A Q E + + Q + T
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
Q + + RGE +E+A + A E +V + E+ S + +++
Sbjct: 2055 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2103
Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
+ E+ +A ++ + L + + + R A+ ++ + +D E +
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2163
Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
L +++ + T L TD N L++ +Q E A + + R
Sbjct: 2164 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2221
Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
+ E+ L A++ R + L+ + +++ QE E K Q+ E LS A
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2276
Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
L Q++ +EKM+ ++++ T+L+ E L Q K L + +A RL+
Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2336
Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
+ L +T E ++ R+L+ + E E+ KL R++ R +E+ + +
Sbjct: 2337 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2396
Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
E ++ L L Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++
Sbjct: 2397 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2454
Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
++ S + + LQ + QS L +D L + ++ +E++ +++ +L +
Sbjct: 2455 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2512
Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
++ + + + +QQME++RQ + + + +EA + ++ K E+LQ+ +++RQQ
Sbjct: 2513 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2569
Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
L E QRL+ +Q ++Q
Sbjct: 2570 EELLAEENQRLREQLQLLEEQ 2590
Score = 158 bits (399), Expect = 1e-37
Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)
Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
+PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ +
Sbjct: 1046 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1104
Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
L A+L++ R + + F L ++ +Q++ + QQ +
Sbjct: 1105 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1164
Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q
Sbjct: 1165 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1221
Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
+ +S +E++++++ ++EE+ +K E + + + + Q+V
Sbjct: 1222 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1277
Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
+++ + K + S +E L EL + +F ++ ++RME+E +R
Sbjct: 1278 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1336
Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
EQ RAE L E + Q Q ++E EE+ R + ++
Sbjct: 1337 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1396
Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
+ S + E+ +L + E+ K + + + +++EE+ ++ LE
Sbjct: 1397 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1453
Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE
Sbjct: 1454 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1511
Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
+A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1569
Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + +
Sbjct: 1570 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1626
Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
+ + Q E+++ K L Q+ E +K+ E +E + +G EQ V+
Sbjct: 1627 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1671
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
+ +L + LEKQ + E Q++ A AE +++ L+ T +++R +
Sbjct: 1672 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1719
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
+ + + ++E ++ ++L+ + ++ E+ E+ R+T +++
Sbjct: 1720 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1773
Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
E ++EL EE A L + ++ E+ +Q E + KL A+ E
Sbjct: 1774 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1833
Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
L+ +K K + + ED+ F LE E + ++ E+L ++ K E
Sbjct: 1834 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1891
Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + +
Sbjct: 1892 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947
Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
+ + L+ + R + +V KS E + + K + E + + +E
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
L L+ Q + +LQ E + +Q + LQ Q+ +
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2061
Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
+DQ+R E + +A +E + A+ E + +++ + E +E
Sbjct: 2062 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2120
Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
KL+K +E + Q + L + + E + + E Q R
Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2166
Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
+ Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+
Sbjct: 2167 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2219
Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279
Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
Q E ++ L++++QAV E+T L + + A+R +
Sbjct: 2280 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2339
Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
+ + +E + LE + Q QLE + + +A E+SR
Sbjct: 2340 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2383
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
E A + A E+ + E+ + QT E + + + L + + E +
Sbjct: 2384 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2443
Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
E + + + + T+ +E ++ T ++QS E S + R + + +
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2501
Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q
Sbjct: 2502 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2561
Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
+ E L++E + L E+L+ L++ +LA E++ ++ NG +
Sbjct: 2562 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2617
Score = 149 bits (376), Expect = 5e-35
Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)
Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
A E++ +R I E DI +LE C + + L + + RE R E KA+A
Sbjct: 962 AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1017
Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
G +L E EK++ E A +R +L+ + LE QV +
Sbjct: 1018 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1071
Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
EK + + + Q E+ L + L E QA+ E + + ++KL Q + P
Sbjct: 1072 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1131
Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
F + + + R +++ L+++ ++ E+ +E++ + ++ + + + R RELEQ
Sbjct: 1132 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190
Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
L +++ D +A+ + Q+QA A + +E E+ L EE
Sbjct: 1191 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1243
Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
+E E+V++ K+ +++ E + +K +E + K+ S +
Sbjct: 1244 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1297
Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
+IQE +E T Q +K + E +R +E + E L Q
Sbjct: 1298 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1340
Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
+R R E+E +EK Q++LA + A ++E + Q +VV E+ A+
Sbjct: 1341 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1395
Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
+ Q + K ++E ++ Q ++ E+ + R+ E+ E+
Sbjct: 1396 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1431
Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
S+ + E E+ + L++ E Q +G + L R + E+ E +
Sbjct: 1432 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1484
Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
+Q++D Q + Q E E+ + + E++ A + +++L+A +E + + +
Sbjct: 1485 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1543
Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
+ + ++ + E EL S ++ + ++LE + E H ++ +E+ E +
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1603
Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
E E+ E ++ LE + K E +++S E K E G
Sbjct: 1604 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1663
Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
E +A+R +A + EL ++ AE ++ L E + L+ + Q +E+
Sbjct: 1664 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1721
Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
L+ L++E Q E++ A + + + L+ ++ + S+S ++ Q L
Sbjct: 1722 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1778
Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
AG L E + E + Q E+ Q A +L + I E LK E
Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1838
Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
+A LKE + E + LA +A+Q R +
Sbjct: 1839 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1883
Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
+SDS + +G+ L F+ A+ G+ E +A D
Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943
Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
+ K + L A Q+ + E + E+ + ++ E +RKA + + LK
Sbjct: 1944 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2001
Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
+ + + RE +S++ + + + L A LQQ +E+SV
Sbjct: 2002 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2061
Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
L A + E A + V L+Q +EQ + QAA
Sbjct: 2062 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2121
Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
E L+K + QA A + ++ ++ +K +++ L Q +Q ++ ++++
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2180
Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
L + L E+L K E + +Q + EL +++ Q + L +L+A R+E +++
Sbjct: 2181 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2238
Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
+ ++T Q+++ +++ E+ E A+L + E D + L +
Sbjct: 2239 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2298
Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
+K + +Q LL+QQK+L E ++++ + QL+EE QG
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2358
Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
R LE+ E K+R+ EMS R E + + ++ G+ R L +++ +
Sbjct: 2359 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2418
Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
E+Q+Q E I EL E EK K + +QT QQ + ++ Q +
Sbjct: 2419 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2478
Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
++ +E+++ + ++ + + ++K+E L Q+ EE+++Q +++ E QRL M
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2538
Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
+E ++++ E EE ++ Q L +
Sbjct: 2539 EEARRRQHEAEEGVRRKQEELQQLEQ 2564
Score = 146 bits (369), Expect = 3e-34
Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)
Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++
Sbjct: 1209 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268
Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
QL ++ +E VI Y D +T L + I+ ++ +
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1328
Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
+ + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q +
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448
Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + +
Sbjct: 1449 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1502
Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
LA+ +K + + E K++ + ++E + E+ E R+R+ E + + V+ +T Q+
Sbjct: 1503 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558
Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
+ R F A+ E SL+ QL+ E + +++ E E+ E+ E
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618
Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
+ K E +L +Q E ++ + E E++ + + + + G A
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1665
Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
+E+ V +L EQ + Q+QL T + + + ELIR L ++
Sbjct: 1666 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1707
Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
E E++ + L E + +LQ+E A QK L E ++ +++V++A K
Sbjct: 1708 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1759
Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
E++ + +E+ K L+ + +L +E L+ E ++ + + E
Sbjct: 1760 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1816
Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
AI ++ K E E+ L E + L+ L F + EE +
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1876
Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
+E RL QL A D EL + ++D Q + ++++I+ L+ E+ A
Sbjct: 1877 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1929
Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
+++L ++ A+ T+ S+ + L R+ +L ++ R E E +V
Sbjct: 1930 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 1977
Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
+ SL E+E K LE+ ++L K ++ RE+ ++ S + +++ +
Sbjct: 1978 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2029
Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
+ + L+AE KA + ++K ++LQ+ L +++ + L+ +
Sbjct: 2030 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2072
Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
R EA+E E+E +V+E+++ + + + K +
Sbjct: 2073 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132
Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
+ + A ++ ++ E+ + Q +K + QEL + + ET+
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2186
Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
K LL EE LKA +++ S + E S Q E+ +
Sbjct: 2187 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2232
Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
I +E R + T F ++ ++ V E ++ + E
Sbjct: 2233 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2276
Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
++Q++E L +++A K L KMQ +EA + LL
Sbjct: 2277 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2320
Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
Q+ +E++ L + ++ + G LE Q Q +E A E L+ R +
Sbjct: 2321 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2377
Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
+S QA A+ + ++ + E+ EK + E Q+K + + ++++ A L
Sbjct: 2378 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2434
Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
+E +AEL+ E + KL+ E L LK E ++ + E L +
Sbjct: 2435 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2481
Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
SE+ + + +E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2534
Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
S + E++R ++A+ +E+ + LE Q LL E R+RE L+ +
Sbjct: 2535 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2592
Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
H++ ++ ++ D L + E +HS
Sbjct: 2593 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2631
Score = 142 bits (359), Expect = 5e-33
Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)
Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
DI ++E R + +LR LD+ ++ Q + Q AQ E+E +
Sbjct: 977 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1024
Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
+ ++ +++ + + A L +L+ T + E+++ + LE+ + R
Sbjct: 1025 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1084
Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
+ E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E
Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1144
Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
+ L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E
Sbjct: 1145 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1203
Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
+ L++ + +I L D+ + + +Q L E+ +K+E Q F K +
Sbjct: 1204 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1263
Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
++ + ++ L+ +K ++ + +E LR E TL + +
Sbjct: 1264 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1323
Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
E + E E+ +++ + +E+ A++EA L+ +++ E + +E +
Sbjct: 1324 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1377
Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
++ + ++ V +E E D +QQ + EE+++ R + +E + ++ +
Sbjct: 1378 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1427
Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
L++++++ + + E + + A E LQ + + + A
Sbjct: 1428 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1473
Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
+ + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+
Sbjct: 1474 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1529
Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
+ E+ R R+ E+ RA VQ + R AE + SF E+
Sbjct: 1530 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1574
Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
+ + E S QE+ + + + +E+ RA Q +E ++ ++E +E
Sbjct: 1575 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1614
Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
+ R Q++A + + V Q + + E +K +EE +E ++
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1663
Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
+ E Q ++ +E ++ K L G Q+ ++ E L+ E
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1709
Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
+++ + E E LQ ++ + L KV E LL SK +
Sbjct: 1710 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1761
Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
+ E ++ L E F + + L + K + + L + Q E
Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1817
Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
E +++ + E T EAEI +K RL+ ++E ++ ++D
Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1877
Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
+ + + ++K D +E + G+ E+T + + Q+EEE+ + S A A
Sbjct: 1878 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1925
Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
+ EL RI E+T SK Q ++E+ E
Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985
Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
Q + + E + K +E + + E +++ L+ E K +
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2045
Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
++ +T QS+ D++ + A R ++ E + RQ E ++Q
Sbjct: 2046 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2105
Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
E Q QA ++ ++ E + + Q E L ++ A + ++ +E R
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2165
Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
++ +E EL L+ QL +K L EL+ + + +VEE+ F + +
Sbjct: 2166 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225
Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
+ I + R + + + + L E + V E R S +Q +A
Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2278
Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
L +E + + + + E+ + +++ + + +++ ++ EL+Q R
Sbjct: 2279 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2330
Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
+ + E++ ++ Q ++ LEA E S++ E K+ E+ R R
Sbjct: 2331 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2384
Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
+++A K EE+ E+LH A ++ + E Q Q+
Sbjct: 2385 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2430
Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
+RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L +
Sbjct: 2431 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2480
Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+
Sbjct: 2481 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2576
Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
+ E L E+ R +EE+ + + + T D A EA
Sbjct: 2577 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2626
Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
+PE S + L+ + A +E I + EE
Sbjct: 2627 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2654
Score = 140 bits (353), Expect = 2e-32
Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)
Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
QE +LE L ++ Q V MK L Q + + ++ +RS+S T
Sbjct: 852 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 900
Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
+ + A++ L + Q + + G E++ +R+ S +Q
Sbjct: 901 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 953
Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
+ ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L +
Sbjct: 954 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 998
Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
++ R+AE Q +AE+E L + L + E++ L E + E L
Sbjct: 999 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1055
Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
+ +Q+ L +K++T+ + L +LK+ Q
Sbjct: 1056 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1115
Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
+ +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++
Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1175
Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
+ A+ + + E + L L+ + S + +L + + +++I+ + + +++
Sbjct: 1176 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1228
Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
+++Q Q L EEIE+ ++ + +++ L+ K LE + +
Sbjct: 1229 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1287
Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+
Sbjct: 1288 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1341
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
+RE+L + + QL + H + E E K L+Q ++ +R RE + +
Sbjct: 1342 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1400
Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
++Q Q+ + + +R AE + E S++ +E+++ + +
Sbjct: 1401 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1451
Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
+Q L +LRA +E + QK ++E+ ++Q E+QR + V
Sbjct: 1452 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1503
Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
+ EK +AL +L+E + A+E + + E+++ Q+++ Q + +
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1561
Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
+LQ + Q S+ E+ A E + + E+ E
Sbjct: 1562 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1614
Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
+ R++++ + L + + L + K ++ + + E+ + + E
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1674
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
+ Q E + +L++ Q+L + + E + E + + L+++L ++
Sbjct: 1675 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1729
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
A QKR + +E + + V+ S A+ S +K+ +G F
Sbjct: 1730 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1783
Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
+ EE ++ L E + Q QL EE A + A A++ +++ E T +A
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1839
Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
++++ ++ + FQ + L ++ +H DI
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1877
Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
E + S+ + K + +RQ E + ++ AS + + ++ +
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937
Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
R A + LR ++E R+ Q +EE +R + + S+ E + + +
Sbjct: 1938 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992
Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
LEE+E LK R + S+ Q Q E Q E + F KE+EL
Sbjct: 1993 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052
Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
+ + E + L E R A ++A ++ E ++ VEE L +S
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2106
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
++ Q+ A ++ AE K E R E ++ +D +++ T +
Sbjct: 2107 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166
Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
++ Q L E D + + L+ RL+A + S+ +L +V E
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225
Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E
Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285
Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
+ ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL +
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345
Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
ET+ + +LE+ +AE+++ +D Q+ K E ++ E++
Sbjct: 2346 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2404
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK
Sbjct: 2405 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2458
Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
E QT + EQL ++T + LS++ + +R IE+ + ++ +
Sbjct: 2459 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2504
Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
L Q + A ++ + R+ + + L S+E + + +A + RK++E+ LE+
Sbjct: 2505 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2564
Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Q Q E L +N+ +++ LE Q + + +E+
Sbjct: 2565 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601
Score = 122 bits (306), Expect = 7e-27
Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)
Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
A E ++ + + QAE + + K + L + E+ L + L +LE+
Sbjct: 1002 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1055
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
+ +L+++ + ++ + ++ + L I+ + A H K AQ + E++
Sbjct: 1056 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1113
Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
+ KL+ Q + + + +R + E L R+ E+E+ E +
Sbjct: 1114 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1167
Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
+L + + +T + L + L++ + A+ L A Q E++ M
Sbjct: 1168 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1223
Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
L ++ QL QE L ++R E VE+ Q + +N D+ EL++V +
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1277
Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
L+ + + K ++G S+I +L T +L + S +++ +++++ +
Sbjct: 1278 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1336
Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
+ Q++ +++ E V AAL Q QL AK +E E +Q
Sbjct: 1337 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1381
Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
Q +R +E D I E Q+ + + I K Q E AE++ L E+++
Sbjct: 1382 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441
Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
++ LE E+++ G EL+ALRA + +A+
Sbjct: 1442 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1474
Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
+E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q +
Sbjct: 1475 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1534
Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
++ ++ Q L+ + + ++ K A + Q E S +E ++
Sbjct: 1535 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1590
Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
Q E+ E+ + A AE E+ E LK + ++L EE K++ Q K
Sbjct: 1591 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1650
Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
+ A A + RE+ + +EG ++ +A
Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1697
Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
+ LRA +G Q L E + + + +Q E L + +A +
Sbjct: 1698 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1752
Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
+ + K K + + EAE + E + R A +Q L E
Sbjct: 1753 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1812
Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
E A+G L+ + E +A E L++ A +R L E A
Sbjct: 1813 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1872
Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K S
Sbjct: 1873 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1919
Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
EK AEL+ EL + + E TL++ K ELEA R A E
Sbjct: 1920 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 1965
Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
+++ RE + ++K A + R + EE+E LK +E ++ + +Q QL
Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2025
Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
E+ QK E + + Q E+ ELQ L+ E+ + ++ + R
Sbjct: 2026 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080
Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Q
Sbjct: 2081 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2140
Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
+ +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL+
Sbjct: 2141 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2200
Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
E +Q + EE+ S R+ + L++ L+ +IE E + L
Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2240
Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
I + T L+ +K++ VA + L A E + +ED + Q + E +
Sbjct: 2241 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2297
Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
L+ E+ V +T + E LL+Q EL ++ +E D M +L E
Sbjct: 2298 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2345
Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
+ + +++T L + +++E E + ++ RAE A+ ++
Sbjct: 2346 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394
Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
+AE + L +T E VTL
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTL 2416
Score = 48.5 bits (114), Expect = 1e-04
Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)
Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
LL LEQ QE+ C + +SE++ + Q+ R + R ++
Sbjct: 954 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1000
Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
P++E + +Q+++Q E+ + L + +EK++ S A T + EL
Sbjct: 1001 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1053
Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
E TL + + ++ L A LE K KT + + A E ++ E Q +
Sbjct: 1054 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1111
Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
E K L+ L+ E+Q+ L L +++ QQ+ +R + + E +
Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1170
Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
LE Q +L VR RE+ L RE L A LQ + + +P D +
Sbjct: 1171 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1229
Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
+++QL ++ + + E+ EK + +Q + KD ++ T + + E KK
Sbjct: 1230 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1289
Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
++QS E + ++ + R +L L Q ++ I + ++ E E + R + L
Sbjct: 1290 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1348
Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
E +L R + + + + + AK ++ E + +Q+ + +
Sbjct: 1349 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1404
Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
+LQ L Q + +Q + A + + ++E I + LQL+ Q+G +
Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1464
Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
+ E RQ E + Q+ +E R ++L +++ + A R+
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1522
Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
++A A +E E + ++ L+ + + AEAE+ +A + S
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582
Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
EHV + + LR E+ R+A
Sbjct: 1583 QEEHVAVAQ-----LREEAERRA 1600
Score = 35.8 bits (81), Expect = 0.86
Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)
Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
+E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A
Sbjct: 2326 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2385
Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
D + Q E+ R E + T+++TL + + H+ E +E+
Sbjct: 2386 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2444
Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
+ E K L EE V Q Q + L ++
Sbjct: 2445 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2494
Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
IE+ +LE++ + Q +E + +Q + +L A++++ARR + E
Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2554
Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H
Sbjct: 2555 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2591
Score = 35.0 bits (79), Expect = 1.5
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
+QLN+ LQ +++ KV + E+ RDL ++ I L +D + +K R + EQ
Sbjct: 396 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 455
Query: 2352 LNEVIEKLQQELANI 2366
+ + +L + L I
Sbjct: 456 MYRRVYRLHERLVAI 470
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 191 bits (486), Expect = 9e-48
Identities = 271/1268 (21%), Positives = 544/1268 (42%), Gaps = 179/1268 (14%)
Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
+++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ +
Sbjct: 1427 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1486
Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
QL QR + E + R EE EA K+ + E+L ++++ S Q +
Sbjct: 1487 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1540
Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
+ E+ + E E R+ + + L R ++A RL + +E + ET
Sbjct: 1541 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1597
Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
RS++++ + +E A ++ + EEH V
Sbjct: 1598 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1630
Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869
+++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E
Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690
Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929
K E RE+ R+ + ++++ +E + L ++ + E A + AE +
Sbjct: 1691 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1747
Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976
E E+Q Q + + RL++E A+ + QELEAE +++ E E+L
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807
Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
+ K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++
Sbjct: 1808 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866
Query: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
+ E + K + L+++ E + E++R+ +++A R + Q +E++L
Sbjct: 1867 AAIGEATRLKTEAEIALKEK----EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922
Query: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Q R+ + L+ + + L + Q++ +I EK
Sbjct: 1923 A-----------QLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
Query: 2155 ELEQAL----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-----RDAIDRKEKEI 2205
ELE L + DT + E +A+ E + + QL AE R+A +R +K +
Sbjct: 1970 ELELELGRIRSNAEDTLRSKE--------QAELEAARQRQLAAEEERRRREAEERVQKSL 2021
Query: 2206 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265
EE Q + L EEV++L ++E ++ QE ++ +L ++ +K A
Sbjct: 2022 AAEEEAARQRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077
Query: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTD 2313
+++ A + Q + + Q +Q+++ +DQL + ++Q + +
Sbjct: 2078 EKAHAFAVQQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134
Query: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2373
+ +EE L + E Q + Q ++ R+E + E + Q E A + QK + +
Sbjct: 2135 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAAD 2191
Query: 2374 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433
A E + K + + +K +EQ E+T ++ L+ET+ + N L +EL L
Sbjct: 2192 A-----EMEKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRL 2239
Query: 2434 KRERESVEKIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
K E + +S E SV V ++ LSK K +E L+ +N F EE
Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAE 2298
Query: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
K + E L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K
Sbjct: 2299 KMKQVAEEAARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLK 2353
Query: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISAL 2604
A L+ Q Q E QE A+ Q+++ ++ Q + R+ E+ ++ L
Sbjct: 2354 AEAELLQQ-QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412
Query: 2605 TLRISEL------------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLEL 2646
LR++E+ E ++H + + +E+V + + +++++ +
Sbjct: 2413 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2472
Query: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL- 2705
++L E + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L
Sbjct: 2473 ERLREAIAELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2530
Query: 2706 ------ASYKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDE 2755
K K E+L ++ + K + Q+ + Q R L + E+ + E E
Sbjct: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590
Query: 2756 TEVQESKK 2763
V+ ++
Sbjct: 2591 EGVRRKQE 2598
Score = 167 bits (424), Expect = 1e-40
Identities = 348/1701 (20%), Positives = 693/1701 (40%), Gaps = 241/1701 (14%)
Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
PE + S L+ + KL + S ++ LE K + R Q A E L+
Sbjct: 1081 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1135
Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
EE + +E AV + E + +K + + Q+ T D L EL A
Sbjct: 1136 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1183
Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R
Sbjct: 1184 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1240
Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075
+ L+ D + + + + + + +Q QAL +++E+ + ++E Q
Sbjct: 1241 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1299
Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
+++ + E+Q + + QL+ V P+ Q SE +E L H E T S+
Sbjct: 1300 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1359
Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK----- 2182
I+ +E + ++E R EQ Q+ E+R+ VEA
Sbjct: 1360 Y----------IKFISETLRRMEEEERLAEQ---------QRAEERERLAEVEAALEKQR 1400
Query: 2183 --PELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
E + + QAER+A + R ++E+ EE +++ + EE+QQL E +
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1460
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 2297
+ + + E+ ++++ + L ++ ++ + L A+ +E E + Q
Sbjct: 1461 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQA 1519
Query: 2298 NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
E+ +L++Q ++++++ R E ++ + + R ++ ++ L E+
Sbjct: 1520 QEEAERLRRQ---------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-- 1568
Query: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNV 2415
+LQ +EEA+ Q +V A ++ ALE +A E+ +
Sbjct: 1569 RLQ-----------------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1611
Query: 2416 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2475
E ++ + SL+ E +V +++ E + + + E E L LK
Sbjct: 1612 FAEKTAQLER------SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLK 1664
Query: 2476 SLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQF 2531
+ E L RL Q E K L + KQ ++ + + G+
Sbjct: 1665 ANEA-----------------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1706
Query: 2532 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2591
E + ++++ + Q++ +++ A +Q +L A QE + + +E E+ Q Q
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--Q 1757
Query: 2592 LREDELGS---DISALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLE 2645
L E+EL + +A T + ELE+++ ++ L+ K + E ++ EK K+ LE
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1817
Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKA 2703
E ++ +E R E K +L EE EA R AE +A
Sbjct: 1818 A----EAGRFRELAEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIG 1870
Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDE 2755
E K +AE +E + + L +D + Q H A+ +E+L+ L K +
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
Query: 2756 TEVQESK----------KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
+E++ K + E L +K S A+ L++ I+
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IR 1979
Query: 2806 INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
N + S+E E+ + ++ +E E + + ++ E R+ A+
Sbjct: 1980 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL---- 2035
Query: 2866 EECGTLKAVIQCLR------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLT 2916
EE LKA ++ R +E + +LA A Q E + + Q + T
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
Q + + RGE +E+A + A E +V + E+ S + +++
Sbjct: 2096 LQQEQSVLDQLRGE-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERL 2144
Query: 2977 SEPWLEERKAYINTISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVF 3034
+ E+ +A ++ + L + + + R A+ ++ + +D E +
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2204
Query: 3035 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RS 3089
L +++ + T L TD N L++ +Q E A + + R
Sbjct: 2205 LRQKAQVEQELTTLRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2262
Query: 3090 LLSEIQALHAQMNG--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
+ E+ L A++ R + L+ + +++ QE E K Q+ E LS A
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEA 2317
Query: 3148 TEL---------QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
L Q++ +EKM+ ++++ T+L+ E L Q K L + +A RL+
Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2377
Query: 3199 KTDEVHLLNDTLAS----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSL 3249
+ L +T E ++ R+L+ + E E+ KL R++ R +E+ + +
Sbjct: 2378 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2437
Query: 3250 ESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309
E ++ L L Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++
Sbjct: 2438 EEIGEK-LHRTELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2495
Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE---- 3365
++ S + + LQ + QS L +D L + ++ +E++ +++ +L +
Sbjct: 2496 LQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2553
Query: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
++ + + + +QQME++RQ + + + +EA + ++ K E+LQ+ +++RQQ
Sbjct: 2554 AQQLREEQQRQQQQMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2610
Query: 3426 VYKLDLEGQRLQGIMQEFQKQ 3446
L E QRL+ +Q ++Q
Sbjct: 2611 EELLAEENQRLREQLQLLEEQ 2631
Score = 158 bits (399), Expect = 1e-37
Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%)
Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206
+PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ +
Sbjct: 1087 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1145
Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257
L A+L++ R + + F L ++ +Q++ + QQ +
Sbjct: 1146 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1205
Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313
A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q
Sbjct: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1262
Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
+ +S +E++++++ ++EE+ +K E + + + + Q+V
Sbjct: 1263 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1318
Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
+++ + K + S +E L EL + +F ++ ++RME+E +R
Sbjct: 1319 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1377
Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
EQ RAE L E + Q Q ++E EE+ R + ++
Sbjct: 1378 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1437
Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521
+ S + E+ +L + E+ K + + + +++EE+ ++ LE
Sbjct: 1438 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1494
Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE
Sbjct: 1495 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1552
Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629
+A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1610
Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687
S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + +
Sbjct: 1611 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1667
Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746
+ + Q E+++ K L Q+ E +K+ E +E + +G EQ V+
Sbjct: 1668 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1712
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
+ +L + LEKQ + E Q++ A AE +++ L+ T +++R +
Sbjct: 1713 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1760
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855
+ + + ++E ++ ++L+ + ++ E+ E+ R+T +++
Sbjct: 1761 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1814
Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901
E ++EL EE A L + ++ E+ +Q E + KL A+ E
Sbjct: 1815 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1874
Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954
L+ +K K + + ED+ F LE E + ++ E+L ++ K E
Sbjct: 1875 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1932
Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + +
Sbjct: 1933 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988
Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069
+ + L+ + R + +V KS E + + K + E + + +E
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
L L+ Q + +LQ E + +Q + LQ Q+ +
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2102
Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
+DQ+R E + +A +E + A+ E + +++ + E +E
Sbjct: 2103 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2161
Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
KL+K +E + Q + L + + E + + E Q R
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2207
Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
+ Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+
Sbjct: 2208 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2260
Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357
QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+
Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320
Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406
Q E ++ L++++QAV E+T L + + A+R +
Sbjct: 2321 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2380
Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
+ + +E + LE + Q QLE + + +A E+SR
Sbjct: 2381 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2424
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
E A + A E+ + E+ + QT E + + + L + + E +
Sbjct: 2425 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2484
Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
E + + + + T+ +E ++ T ++QS E S + R + + +
Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2542
Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q
Sbjct: 2543 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2602
Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690
+ E L++E + L E+L+ L++ +LA E++ ++ NG +
Sbjct: 2603 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2658
Score = 149 bits (376), Expect = 5e-35
Identities = 351/1706 (20%), Positives = 690/1706 (40%), Gaps = 270/1706 (15%)
Query: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
A E++ +R I E DI +LE C + + L + + RE R E KA+A
Sbjct: 1003 AQEESRCQRCISELKDIRLQLEA---CETRTVHRLRLPLDK-EPARECAQRIAEQQKAQA 1058
Query: 1988 -----GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
G +L E EK++ E A +R +L+ + LE QV +
Sbjct: 1059 EVEGLGKGVARLSAEAEKVLALP-EPSPAAPTLRSELELTLGKLE-----QVRSLSAIYL 1112
Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDRE-HERDVFQQEIQKLEQQLKVV-PR 2099
EK + + + Q E+ L + L E QA+ E + + ++KL Q + P
Sbjct: 1113 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1172
Query: 2100 FQPISEHQTREVEQLANHLKEKT-DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
F + + + R +++ L+++ ++ E+ +E++ + ++ + + + R RELEQ
Sbjct: 1173 FDALRD-ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231
Query: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
L +++ D +A+ + Q+QA A + +E E+ L EE
Sbjct: 1232 -LGRQLRYYRESADPLGAWLQDARRR---QEQIQAMPLADSQAVREQLRQEQAL---LEE 1284
Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
+E E+V++ K+ +++ E + +K +E + K+ S +
Sbjct: 1285 IERHGEKVEECQRFA----KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES-- 1338
Query: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
+IQE +E T Q +K + E +R +E + E L Q
Sbjct: 1339 -------VIQEYVDLRTHYSELTTLTSQYIKFIS---------ETLRRMEEE-ERLAEQQ 1381
Query: 2339 ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
+R R E+E +EK Q++LA + A ++E + Q +VV E+ A+
Sbjct: 1382 RAEERERLAEVEA---ALEK-QRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAV 1436
Query: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQ-ELFSLKRERESVEKIQSIPENSVNVAIDH 2457
+ Q + K ++E ++ Q ++ E+ + R+ E+ E+
Sbjct: 1437 DAQQQ---------KRSIQEELQQLRQSSEAEIQAKARQAEAAER--------------- 1472
Query: 2458 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
S+ + E E+ + L++ E Q +G + L R + E+ E +
Sbjct: 1473 -SRLRIEEEIRVVRLQLEATERQ------RGGAEGELQALRARAEEAEAQKRQAQEEAER 1525
Query: 2518 CYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
+Q++D Q + Q E E+ + + E++ A + +++L+A +E + + +
Sbjct: 1526 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-EEAERRLRQAEV 1584
Query: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
+ + ++ + E EL S ++ + ++LE + E H ++ +E+ E +
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1644
Query: 2637 LEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTTTELFHSNEESG 2686
E E+ E ++ LE + K E +++S E K E G
Sbjct: 1645 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1704
Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
E +A+R +A + EL ++ AE ++ L E + L+ + Q +E+
Sbjct: 1705 KAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762
Query: 2747 LSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
L+ L++E Q E++ A + + + L+ ++ + S+S ++ Q L
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---STSEKSKQRLEAE 1819
Query: 2802 AGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
AG L E + E + Q E+ Q A +L + I E LK E
Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1879
Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI----------------- 2900
+A LKE + E + LA +A+Q R +
Sbjct: 1880 EIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924
Query: 2901 --CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES-------ESATD 2937
+SDS + +G+ L F+ A+ G+ E +A D
Sbjct: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984
Query: 2938 SFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEERKAYINTISSLK 2995
+ K + L A Q+ + E + E+ + ++ E +RKA + + LK
Sbjct: 1985 TLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2042
Query: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLA---------------LQQVFLEERSV 3040
+ + + RE +S++ + + + L A LQQ +E+SV
Sbjct: 2043 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2102
Query: 3041 L------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQG---VEYQAAM 3079
L A + E A + V L+Q +EQ + QAA
Sbjct: 2103 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162
Query: 3080 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
E L+K + QA A + ++ ++ +K +++ L Q +Q ++ ++++
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQ 2221
Query: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
L + L E+L K E + +Q + EL +++ Q + L +L+A R+E +++
Sbjct: 2222 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSKLKA-RIEAENR 2279
Query: 3200 TDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDKEELEDLKFSLE 3250
+ ++T Q+++ +++ E+ E A+L + E D + L +
Sbjct: 2280 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2339
Query: 3251 SQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE-QG--------- 3293
+K + +Q LL+QQK+L E ++++ + QL+EE QG
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2399
Query: 3294 -RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPPLPSEDLLK--- 3346
R LE+ E K+R+ EMS R E + + ++ G+ R L +++ +
Sbjct: 2400 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2459
Query: 3347 --ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQME--KDRQVHR 3388
E+Q+Q E I EL E EK K + +QT QQ + ++ Q +
Sbjct: 2460 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2519
Query: 3389 KTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKLDLEGQRLQGIM 3440
++ +E+++ + ++ + + ++K+E L Q+ EE+++Q +++ E QRL M
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2579
Query: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
+E ++++ E EE ++ Q L +
Sbjct: 2580 EEARRRQHEAEEGVRRKQEELQQLEQ 2605
Score = 146 bits (369), Expect = 3e-34
Identities = 318/1599 (19%), Positives = 652/1599 (40%), Gaps = 275/1599 (17%)
Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909
L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++
Sbjct: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309
Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946
QL ++ +E VI Y D +T L + I+ ++ +
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369
Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056
+ + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q +
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489
Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + +
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1543
Query: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE----QALLVSADTFQK 2169
LA+ +K + + E K++ + ++E + E+ E R+R+ E + + V+ +T Q+
Sbjct: 1544 LASRVKAEAEAARE----KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599
Query: 2170 VED------RKHFGAVEAKPELSLE------VQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
+ R F A+ E SL+ QL+ E + +++ E E+ E+ E
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659
Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
+ K E +L +Q E ++ + E E++ + + + + G A
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA------------- 1706
Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
+E+ V +L EQ + Q+QL T + + + ELIR L ++
Sbjct: 1707 ----------EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAE 1748
Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
E E++ + L E + +LQ+E A QK L E ++ +++V++A K
Sbjct: 1749 TE----QGEQQRQLLEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKAR 1800
Query: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN----- 2452
E++ + +E+ K L+ + +L +E L+ E ++ + + E
Sbjct: 1801 AEEESRSTSEKS---KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857
Query: 2453 ---------VAIDHLSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIIN 2496
AI ++ K E E+ L E + L+ L F + EE +
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1917
Query: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
+E RL QL A D EL + ++D Q + ++++I+ L+ E+ A
Sbjct: 1918 IEERLAQLRK---ASDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAE 1970
Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
+++L ++ A+ T+ S+ + L R+ +L ++ R E E +V
Sbjct: 1971 LELELGRIRSNAE-----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQ 2018
Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
+ SL E+E K LE+ ++L K ++ RE+ ++ S + +++ +
Sbjct: 2019 K---SLAAEEEAAR-QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAA 2070
Query: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
+ + L+AE KA + ++K ++LQ+ L +++ + L+ +
Sbjct: 2071 Q--------------KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2113
Query: 2737 RDHLAEAKEKLSILEKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
R EA+E E+E +V+E+++ + + + K +
Sbjct: 2114 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETET 2852
+ + A ++ ++ E+ + Q +K + QEL + + ET+
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDH 2227
Query: 2853 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
K LL EE LKA +++ S + E S Q E+ +
Sbjct: 2228 QKN-------LLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR------ 2273
Query: 2913 IYLTHSQGFDIASEGRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2970
I +E R + T F ++ ++ V E ++ + E
Sbjct: 2274 ----------IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EA 2317
Query: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL 3030
++Q++E L +++A K L KMQ +EA + LL
Sbjct: 2318 ARLRQLAEEDLAQQRALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQ 2361
Query: 3031 QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
Q+ +E++ L + ++ + G LE Q Q +E A E L+ R +
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAE 2418
Query: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
+S QA A+ + ++ + E+ EK + E Q+K + + ++++ A L
Sbjct: 2419 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERL 2475
Query: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL 3210
+E +AEL+ E + KL+ E L LK E ++ + E L +
Sbjct: 2476 RE-------AIAELERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSF 2522
Query: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
SE+ + + +E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRL 2575
Query: 3271 NESQQKIESQRMLYDAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE 3321
S + E++R ++A+ +E+ + LE Q LL E R+RE L+ +
Sbjct: 2576 VASME--EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2633
Query: 3322 ---LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
H++ ++ ++ D L + E +HS
Sbjct: 2634 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2672
Score = 142 bits (359), Expect = 5e-33
Identities = 365/1889 (19%), Positives = 750/1889 (39%), Gaps = 306/1889 (16%)
Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
DI ++E R + +LR LD+ ++ Q + Q AQ E+E +
Sbjct: 1018 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1065
Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530
+ ++ +++ + + A L +L+ T + E+++ + LE+ + R
Sbjct: 1066 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1125
Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580
+ E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E
Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1185
Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
+ L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E
Sbjct: 1186 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1244
Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689
+ L++ + +I L D+ + + +Q L E+ +K+E Q F K +
Sbjct: 1245 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1304
Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745
++ + ++ L+ +K ++ + +E LR E TL + +
Sbjct: 1305 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1364
Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
E + E E+ +++ + +E+ A++EA L+ +++ E + +E +
Sbjct: 1365 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1418
Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865
++ + ++ V +E E D +QQ + EE+++ R + +E + ++ +
Sbjct: 1419 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1468
Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
L++++++ + + E + + A E LQ + + + A
Sbjct: 1469 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1514
Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
+ + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+
Sbjct: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1570
Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
+ E+ R R+ E+ RA VQ + R AE + SF E+
Sbjct: 1571 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1615
Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105
+ + E S QE+ + + + +E+ RA Q +E ++ ++E +E
Sbjct: 1616 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1655
Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165
+ R Q++A + + V Q + + E +K +EE +E ++
Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1704
Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
+ E Q ++ +E ++ K L G Q+ ++ E L+ E
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1750
Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
+++ + E E LQ ++ + L KV E LL SK +
Sbjct: 1751 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1802
Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
+ E ++ L E F + + L + K + + L + Q E
Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1858
Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396
E +++ + E T EAEI +K RL+ ++E ++ ++D
Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1918
Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456
+ + + ++K D +E + G+ E+T + + Q+EEE+ + S A A
Sbjct: 1919 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1966
Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491
+ EL RI E+T SK Q ++E+ E
Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026
Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549
Q + + E + K +E + + E +++ L+ E K +
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2086
Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597
++ +T QS+ D++ + A R ++ E + RQ E ++Q
Sbjct: 2087 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2146
Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652
E Q QA ++ ++ E + + Q E L ++ A + ++ +E R
Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2206
Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
++ +E EL L+ QL +K L EL+ + + +VEE+ F + +
Sbjct: 2207 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266
Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
+ I + R + + + + L E + V E R S +Q +A
Sbjct: 2267 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2319
Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
L +E + + + + E+ + +++ + + +++ ++ EL+Q R
Sbjct: 2320 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2371
Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884
+ + E++ ++ Q ++ LEA E S++ E K+ E+ R R
Sbjct: 2372 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2425
Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944
+++A K EE+ E+LH A ++ + E Q Q+
Sbjct: 2426 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2471
Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004
+RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L +
Sbjct: 2472 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2521
Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+
Sbjct: 2522 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121
R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2617
Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
+ E L E+ R +EE+ + + + T D A EA
Sbjct: 2618 NQRLREQLQLLEEQHRAALAHSEEVTASQ----------VAATKTLPNGRDALDGPAAEA 2667
Query: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
+PE S + L+ + A +E I + EE
Sbjct: 2668 EPEHSFD-GLRRKVSAQRLQEAGILSAEE 2695
Score = 140 bits (353), Expect = 2e-32
Identities = 359/1897 (18%), Positives = 770/1897 (40%), Gaps = 220/1897 (11%)
Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
QE +LE L ++ Q V MK L Q + + ++ +RS+S T
Sbjct: 893 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 941
Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
+ + A++ L + Q + + G E++ +R+ S +Q
Sbjct: 942 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 994
Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
+ ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L +
Sbjct: 995 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1039
Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
++ R+AE Q +AE+E L + L + E++ L E + E L
Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1096
Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711
+ +Q+ L +K++T+ + L +LK+ Q
Sbjct: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1156
Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
+ +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++
Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1216
Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830
+ A+ + + E + L L+ + S + +L + + +++I+ + + +++
Sbjct: 1217 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1269
Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
+++Q Q L EEIE+ ++ + +++ L+ K LE + +
Sbjct: 1270 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1328
Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+
Sbjct: 1329 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1382
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005
+RE+L + + QL + H + E E K L+Q ++ +R RE + +
Sbjct: 1383 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1441
Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
++Q Q+ + + +R AE + E S++ +E+++ + +
Sbjct: 1442 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1492
Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125
+Q L +LRA +E + QK ++E+ ++Q E+QR + V
Sbjct: 1493 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1544
Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181
+ EK +AL +L+E + A+E + + E+++ Q+++ Q + +
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1602
Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
+LQ + Q S+ E+ A E + + E+ E
Sbjct: 1603 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1655
Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
+ R++++ + L + + L + K ++ + + E+ + + E
Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1715
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
+ Q E + +L++ Q+L + + E + E + + L+++L ++
Sbjct: 1716 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1770
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
A QKR + +E + + V+ S A+ S +K+ +G F
Sbjct: 1771 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1824
Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
+ EE ++ L E + Q QL EE A + A A++ +++ E T +A
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1880
Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
++++ ++ + FQ + L ++ +H DI
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1918
Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595
E + S+ + K + +RQ E + ++ AS + + ++ +
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978
Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
R A + LR ++E R+ Q +EE +R + + S+ E + + +
Sbjct: 1979 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033
Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706
LEE+E LK R + S+ Q Q E Q E + F KE+EL
Sbjct: 2034 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093
Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
+ + E + L E R A ++A ++ E ++ VEE L +S
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2147
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817
++ Q+ A ++ AE K E R E ++ +D +++ T +
Sbjct: 2148 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207
Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
++ Q L E D + + L+ RL+A + S+ +L +V E
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266
Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E
Sbjct: 2267 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2326
Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
+ ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL +
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2386
Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035
ET+ + +LE+ +AE+++ +D Q+ K E ++ E++
Sbjct: 2387 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2445
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK
Sbjct: 2446 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2499
Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
E QT + EQL ++T + LS++ + +R IE+ + ++ +
Sbjct: 2500 S-------EEMQTVQQEQLL----QETQALQQSFLSEKD---SLLQRERFIEQEKAKLEQ 2545
Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPEL--SLEVQLQAERDA---IDRKEKEITNLEE 2210
L Q + A ++ + R+ + + L S+E + + +A + RK++E+ LE+
Sbjct: 2546 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2605
Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Q Q E L +N+ +++ LE Q + + +E+
Sbjct: 2606 QRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642
Score = 122 bits (306), Expect = 7e-27
Identities = 323/1582 (20%), Positives = 622/1582 (39%), Gaps = 228/1582 (14%)
Query: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
A E ++ + + QAE + + K + L + E+ L + L +LE+
Sbjct: 1043 ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL-- 1096
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEIDQ 2296
+ +L+++ + ++ + ++ + L I+ + A H K AQ + E++
Sbjct: 1097 --TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1154
Query: 2297 LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
+ KL+ Q + + + +R + E L R+ E+E+ E +
Sbjct: 1155 TKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRERV 1208
Query: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNV 2415
+L + + +T + L + L++ + A+ L A Q E++ M
Sbjct: 1209 AQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP-- 1264
Query: 2416 LKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
L ++ QL QE L ++R E VE+ Q + +N D+ EL++V +
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTYKA 1318
Query: 2473 ALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
L+ + + K ++G S+I +L T +L + S +++ +++++ +
Sbjct: 1319 QLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1377
Query: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
+ Q++ +++ E V AAL Q QL AK +E E +Q
Sbjct: 1378 AE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKELQQ 1422
Query: 2589 LNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLL 2644
Q +R +E D I E Q+ + + I K Q E AE++ L E+++
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482
Query: 2645 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
++ LE E+++ G EL+ALRA + +A+
Sbjct: 1483 VVRLQLEATERQR---------------------------GGAEGELQALRARAEEAEAQ 1515
Query: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
+E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q +
Sbjct: 1516 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1575
Query: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEIIS 2822
++ ++ Q L+ + + ++ K A + Q E S +E ++
Sbjct: 1576 ERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1631
Query: 2823 QFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2881
Q E+ E+ + A AE E+ E LK + ++L EE K++ Q K
Sbjct: 1632 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1691
Query: 2882 EGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
+ A A + RE+ + +EG ++ +A
Sbjct: 1692 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRLAA 1738
Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYINT 2990
+ LRA +G Q L E + + + +Q E L + +A +
Sbjct: 1739 EQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1793
Query: 2991 ISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLL 3042
+ + K K + + EAE + E + R A +Q L E
Sbjct: 1794 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1853
Query: 3043 AAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQAL 3097
E A+G L+ + E +A E L++ A +R L E A
Sbjct: 1854 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1913
Query: 3098 H-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K S
Sbjct: 1914 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK---------AS 1960
Query: 3156 SEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
EK AEL+ EL + + E TL++ K ELEA R A E
Sbjct: 1961 FEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAAEE 2006
Query: 3214 QKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3270
+++ RE + ++K A + R + EE+E LK +E ++ + +Q QL
Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2066
Query: 3271 NESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL----- 3322
E+ QK E + + Q E+ ELQ L+ E+ + ++ + R
Sbjct: 2067 QEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
Query: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQTRQ 3378
A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Q
Sbjct: 2122 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2181
Query: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
+ +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL+
Sbjct: 2182 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2241
Query: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
E +Q + EE+ S R+ + L++ L+ +IE E + L
Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR-----AL 2281
Query: 3499 IEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3558
I + T L+ +K++ VA + L A E + +ED + Q + E +
Sbjct: 2282 ILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAEKM 2338
Query: 3559 LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEE 3618
L+ E+ V +T + E LL+Q EL ++ +E D M +L E
Sbjct: 2339 LK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQLAE 2386
Query: 3619 QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVYKL 3676
+ + +++T L + +++E E + ++ RAE A+ ++
Sbjct: 2387 ETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435
Query: 3677 KAELRNDSLLQTLSPDSEHVTL 3698
+AE + L +T E VTL
Sbjct: 2436 QAEEIGEKLHRTELATQEKVTL 2457
Score = 48.5 bits (114), Expect = 1e-04
Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%)
Query: 3060 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3116
LL LEQ QE+ C + +SE++ + Q+ R + R ++
Sbjct: 995 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1041
Query: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3175
P++E + +Q+++Q E+ + L + +EK++ S A T + EL
Sbjct: 1042 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1094
Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
E TL + + ++ L A LE K KT + + A E ++ E Q +
Sbjct: 1095 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1152
Query: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
E K L+ L+ E+Q+ L L +++ QQ+ +R + + E +
Sbjct: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1211
Query: 3296 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3347
LE Q +L VR RE+ L RE L A LQ + + +P D +
Sbjct: 1212 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1270
Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3405
+++QL ++ + + E+ EK + +Q + KD ++ T + + E KK
Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330
Query: 3406 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
++QS E + ++ + R +L L Q ++ I + ++ E E + R + L
Sbjct: 1331 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389
Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3522
E +L R + + + + + AK ++ E + +Q+ + +
Sbjct: 1390 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1445
Query: 3523 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
+LQ L Q + +Q + A + + ++E I + LQL+ Q+G +
Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505
Query: 3579 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
+ E RQ E + Q+ +E R ++L +++ + A R+
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1563
Query: 3638 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3691
++A A +E E + ++ L+ + + AEAE+ +A + S
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623
Query: 3692 DSEHVTLKRIYGKYLRAESFRKA 3714
EHV + + LR E+ R+A
Sbjct: 1624 QEEHVAVAQ-----LREEAERRA 1641
Score = 35.8 bits (81), Expect = 0.86
Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%)
Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51
+E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A
Sbjct: 2367 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2426
Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110
D + Q E+ R E + T+++TL + + H+ E +E+
Sbjct: 2427 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2485
Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170
+ E K L EE V Q Q + L ++
Sbjct: 2486 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2535
Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
IE+ +LE++ + Q +E + +Q + +L A++++ARR + E
Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2595
Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282
E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H
Sbjct: 2596 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2632
Score = 35.0 bits (79), Expect = 1.5
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQ 2351
+QLN+ LQ +++ KV + E+ RDL ++ I L +D + +K R + EQ
Sbjct: 437 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 496
Query: 2352 LNEVIEKLQQELANI 2366
+ + +L + L I
Sbjct: 497 MYRRVYRLHERLVAI 511
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 182 bits (462), Expect = 6e-45
Identities = 381/1857 (20%), Positives = 779/1857 (41%), Gaps = 315/1857 (16%)
Query: 301 LQEKIKVYEMEQ-DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359
LQ+ ++ E+ + K V+N ++ + ++++ I+ L + EK +E + + +K L
Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGR---HEKFKVESEQQYFEIEKRL 61
Query: 360 GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419
QE++V + +E ++++LEL + + +E+ K+L E Q RN
Sbjct: 62 SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL----EIAQDRNIA--------- 108
Query: 420 QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHKGEMENALRS 477
++ + R E+L AE K++LIR + ++Q E T + L+
Sbjct: 109 --IQSQFTRTKEELEAE------------KRDLIRTNERLSQELEYLTEDVKRLNEKLKE 154
Query: 478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEK---------LKEELGLILEEKCALQR 528
SN T E Q+KL + +++++K ++ ++EK L EL +E AL R
Sbjct: 155 -SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213
Query: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST-VEDLKAEIVSASESRKELEL 587
+ + + EL + E + + EQ + L +++ L VEDL ++ A E + +E
Sbjct: 214 EKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE 273
Query: 588 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647
K E+ N IKL L K +A D A+S E L E +K +D
Sbjct: 274 KFHNEL-NAHIKLSNLYK--SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD---- 326
Query: 648 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS------- 700
H + +E+ KD + ++I L+ E+ + + K + + +S
Sbjct: 327 HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVA 386
Query: 701 -------KLKDLQQSLVNSKSE---------EMTLQINELQKEIE----ILRQEEKEKGT 740
KL +L + V ++ + + ++E+ KE+E IL+++ +E
Sbjct: 387 KIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYER 446
Query: 741 LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE 800
++ V L +K LE+ MKE + LQE + ++S+L+ + + +E +K +SQ+
Sbjct: 447 AQKAVASLSVK---LEQAMKEIQR-LQEDTDKANKQSSVLERDNRRMEIQVK---DLSQQ 499
Query: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
R++ ++ +++ + ++E+ + D+ +++ + RN
Sbjct: 500 IRVLLMELEEARGNHVIRDEEVS-----SADISSSSEVISQHLVSYRNI----------- 543
Query: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKS--------KLK-ALNEELHLQRINPTTVK 911
+ELQ++ LL +L +++ ++E E S KL+ AL E L++ ++
Sbjct: 544 -EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602
Query: 912 MKSSVFDE-DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS--------DL 962
+ S+ + D + + G + + L + + ++ SQ +S +
Sbjct: 603 LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
Query: 963 SEQLKQKHGEISFLNEEVKSLKQEK-EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
+E ++ K + L E ++ K+EK E ++ +LE + + +++S +T++S+ LD
Sbjct: 663 TEAIEAK-AALKQLQEIFENYKKEKAENEKIQNEQLEKL--QEQVTDLRSQNTKISTQLD 719
Query: 1022 GV---VTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSV 1078
M EG ++ K+ + KQEQ+I +
Sbjct: 720 FASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ------------KQEQIINTMTQDL 767
Query: 1079 TKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEA-------QRICLSLVYSTHVDQV 1131
+ A + L+KE +LK + L Q E+ Q + L+ + + + +
Sbjct: 768 RGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT--IQGI 825
Query: 1132 REYMENEKDKALCS----LKEELIFAQEEKIKELQKIH----QLELQTMKTQETGDEGKP 1183
E E E + L S L+ E+ +++ E+++ H L++Q + T+ D
Sbjct: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
Query: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAE--DKENSGDYISENEDPE 1241
LHL +L K +E + Q L ++ + + + + + +KE+ D +S+ E
Sbjct: 886 LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945
Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
Q V D +E + T + V E+Y ++ T L EE+L KE+
Sbjct: 946 EQ-----VNDLKERLKTSTSNV-EQYQAMV---TSL----------------EESLNKEK 980
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
Q+T E++ N + +L + + T+LE+++ E+E LQ + ++
Sbjct: 981 --------QVT--EEVRKNIEVRLKESAEFQ-TQLEKKLMEVEKEKQELQDDKRRAIESM 1029
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
E ++ L+K L +V + + E A+R
Sbjct: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC--------------------- 1068
Query: 1422 VKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVC 1481
+E+ I + +Y+ +L A V ++ A Q ++++ + E T ++ +
Sbjct: 1069 -QEQAKIAVEAQNKYERELMLHAADV-EALQAAKEQVSKMASVRQHLEETTQKAESQLL- 1125
Query: 1482 QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPES 1541
+ + + ++ +D++ D++ ++ + L ++ + +++ S + P +
Sbjct: 1126 ECKASWEERERMLKDEVSKCVCRCEDLE--KQNRLLHDQIEKLSDKVVASVKEGVQGPLN 1183
Query: 1542 KDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEH 1601
+++SEE S+++ + + I E ++ + Q+E +R +
Sbjct: 1184 ----VSLSEEGKSQEQILEILRFIRREKEIA------ETRFEVAQVESLR---------Y 1224
Query: 1602 QQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELE 1661
+Q ELL + + ++E++Q K + + + N+V E ++L EE E
Sbjct: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
Query: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNER 1721
L+Q L + +L Q N E EK+L EDV N+
Sbjct: 1285 RLEQ-DLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL--LEEDVKRWKARNQH 1341
Query: 1722 YALQKAN---NRLLKILLEVVKTTAAVE---ETIGRHVLGILDRSSKSQSSASLIWRSEA 1775
Q+ + K+L E T ++ E IGR ++ ++S+ASL
Sbjct: 1342 LVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRL------KAEIARSNASLTNNQNL 1395
Query: 1776 EASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEI 1835
S+K +++ R E+I D+ I++ KV + + + G
Sbjct: 1396 IQSLKEDLNK--VRTEKETIQK----DLDAKIIDIQEKV--------KTITQVKKIGRRY 1441
Query: 1836 DPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEATESL 1893
+ EEL +A +K++E +++S Q +H V + + ++E+ Q + ++SL
Sbjct: 1442 KTQYEEL--------KAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSL 1493
Query: 1894 KCQ-EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952
+ Q E L++ L E+ + + L E+ +Q ++++ RL Q+L
Sbjct: 1494 ESQVENLQKTLSEKE--------------------TEARNLQEQTVQLQSEL-SRLRQDL 1532
Query: 1953 LCASNRLQELEAEQQQIQEERELLSRQKEAMK---AEAGPVEQQLLQETEKLMKEKLEVQ 2009
+R + E +QQI E+ E + A K A V+ QL +E E+L + +
Sbjct: 1533 ---QDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589
Query: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDLRQQ--NQALEKQ 2061
Q +D+L ++ AL+ E ++SR + QE++ E D Q+ N+ E+Q
Sbjct: 1590 QQ----KDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQ 1642
Score = 177 bits (450), Expect = 1e-43
Identities = 348/1733 (20%), Positives = 733/1733 (42%), Gaps = 232/1733 (13%)
Query: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE----EQVSRFIELEQE-- 2043
V QQ+L+ TE L K VQ + EK D Q ++ L+ E E ++ E+E+
Sbjct: 4 VLQQVLERTE-LNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS 62
Query: 2044 -KNTELMDLRQQNQALEKQLEKMR---KFLDEQAIDREHERD---VFQQEIQKLEQQLKV 2096
L++ ++ Q+L +LEK+ K L E+ + E +D Q + + +++L+
Sbjct: 63 HSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEA 122
Query: 2097 VPR-FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
R +E ++E+E L +K +K E +K +LQ + E +++R +
Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182
Query: 2156 LEQ--ALLVSADTF------QKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITN 2207
LEQ LL S +T+ K ++ G + L L+ L+ +++ + R E+++
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNG 242
Query: 2208 LE---EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2264
L+ E L++ E+L K +E ++ +E + +L K DD E A
Sbjct: 243 LKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE----A 298
Query: 2265 IKESDAMSTQDQHVLF---GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321
+ ++ H L G+ + IQ+ +E++Q +Q+ K + KI K +E N
Sbjct: 299 KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK-EMLEKIGRLEKELENAN 357
Query: 2322 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
+L+ + + L ++ + ++ + KL EL N +T E
Sbjct: 358 DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL-TELYNAYVETQDQLLLEKLEN 416
Query: 2382 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2441
+ LD ++ E A ++ EE + + + K+ Q +E+ L+ + +
Sbjct: 417 KRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476
Query: 2442 KIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFE-ENGKGSIINLETR 2500
K S+ L +D +E+ +K L Q E E +G+ + +
Sbjct: 477 KQSSV-----------LERDNRRMEI-----QVKDLSQQIRVLLMELEEARGNHVIRDEE 520
Query: 2501 LLQLESTVSAKDL-ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQI 2559
+ + + S++ + + Y+ I+++Q+Q Q + +++ ++ E++ ++ ++++
Sbjct: 521 VSSADISSSSEVISQHLVSYRNIEELQQQNQ-RLLVALRELGETREREEQETTSSKITEL 579
Query: 2560 QLEAVQEYAKFCQ-------DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELE 2612
QL+ + Q Q + S + ++ + + + + A +L L
Sbjct: 580 QLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLA 639
Query: 2613 SQVVEMHTS-LILEKEQVEIAEK-NVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE 2670
S TS + V + E +E + L +LQ++ E +K++ E EK ++ Q +
Sbjct: 640 STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK 699
Query: 2671 VLKTTTELFHSNEESGFFNELEALRAESV-----ATKAELASYKEKAEKLQEELLVKETN 2725
+ + T+L N + + + R E + + E+ S E+ +KL +E
Sbjct: 700 LQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQI 759
Query: 2726 MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS---KSIASQT 2782
+ ++ +DL + LA A+ + L+KE E M + ++LS +S+ ++
Sbjct: 760 INTMTQDLRGANEKLAVAEVRAENLKKEKE----------MLKLSEVRLSQQRESLLAEQ 809
Query: 2783 DGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIE-KMQELHA----A 2837
G + ++ QT Q +++ + + + E++ IS +K+E ++++ H
Sbjct: 810 RGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNL 869
Query: 2838 EILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT 2897
++ ++++ +TET H +LLK + + Q L + E
Sbjct: 870 DVQLLDTKRQLDTET--NLHLNTKELLKNAQKEIATLKQHLSNMEVQ------------- 914
Query: 2898 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV 2957
+S S G+G D+ S+ R ++E + +++K V V
Sbjct: 915 ---VASQSSQRTGKGQPSNKEDVDDLVSQLR--QTEEQVNDLKERLKTSTSNVEQYQAMV 969
Query: 2958 LSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHE 3017
SL ES + +QV+E E RK N LK+ + Q Q E ++ + + +
Sbjct: 970 TSLEESLNKE------KQVTE---EVRK---NIEVRLKE-SAEFQTQLEKKLMEVEKEKQ 1016
Query: 3018 SFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQR--IQEQGVEY 3075
D + + +++Q L E L++ + E+ + L N + R QEQ
Sbjct: 1017 ELQDDKRRAIESMEQQ-LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA--- 1072
Query: 3076 QAAMECLQKADRRSLL--SEIQALHA--QMNGRKITLKR--EQESEKPSQELLEYNIQ-- 3127
+ A+E K +R +L ++++AL A + + ++++ E+ ++K +LLE
Sbjct: 1073 KIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWE 1132
Query: 3128 --------------------QKQSQMLEMQVE------LSSMKDRA-----TELQEQLSS 3156
+KQ+++L Q+E ++S+K+ L E+ S
Sbjct: 1133 ERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKS 1192
Query: 3157 EKMVVAELK-----SELAQTKLELETTLKAQHKHL-----KELEAFRLEVKDKTDEVHLL 3206
++ ++ L+ E+A+T+ E+ +++ +EL+ + + + ++V +
Sbjct: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVT 1252
Query: 3207 NDTLASEQ---KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL- 3262
T+A + KK+ + +E K L +ER +++L+ ++ K R L+L++L
Sbjct: 1253 AKTMAQHEELMKKTETMNVVMETNK-MLREEKERLEQDLQQMQ-----AKVRKLELDILP 1306
Query: 3263 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL------------ELQVLLESEKV--- 3307
L++ L+E +++++ L + + + RN E + LL ++V
Sbjct: 1307 LQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTK 1366
Query: 3308 RIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK------ELQKQL-------EE 3354
RI++++ + R + A+ +S Q+ EDL K +QK L +E
Sbjct: 1367 RIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQE 1426
Query: 3355 KHSRIVELLNETEKYKLDSLQTRQQMEK-------------DRQVHRKTLQTEQEANTEG 3401
K I ++ +YK + + Q +K ++ V + +Q +E +
Sbjct: 1427 KVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA 1486
Query: 3402 QKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILY 3461
+ K L+S+VE+LQ+ L EK + L + +LQ + ++ +R + E R
Sbjct: 1487 ETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQI 1546
Query: 3462 QNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM----IRQ 3517
E T ++ + +++ L + TKE+ +L + NG EL++ ++
Sbjct: 1547 TEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENE--ELKQRNGALDQQKDELDVRITALKS 1604
Query: 3518 KLQCVASKLQVLPQKASER-LQFETADDEDFIWVQENIDEIILQLQKLTGQQG 3569
+ + S+L+ ++ ER L+ E V E +I L+ +G++G
Sbjct: 1605 QYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
Score = 165 bits (418), Expect = 7e-40
Identities = 336/1710 (19%), Positives = 723/1710 (42%), Gaps = 235/1710 (13%)
Query: 1838 ENEELMLNISSRLQAAVEKLLEAISETSS-QLEHAKVT-QTELMRESFRQKQEA------ 1889
E+E+ I RL + E+L+ E S +LE K+ Q + + E ++ + A
Sbjct: 49 ESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIA 108
Query: 1890 --TESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
++ + +EEL + R E+L+ EL Y E +++ EK +
Sbjct: 109 IQSQFTRTKEELEAEKRDLIRTNERLSQELE--------YLTEDV---KRLNEKLKESNT 157
Query: 1948 LEQELLCASNRLQ----ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK 2003
+ EL + LQ ++ ++++++E+ELL Q + E +LL +
Sbjct: 158 TKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGN 217
Query: 2004 EKLEVQCQAEKVRDD---LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEK 2060
E LE++C E +++ L++Q+ L+ E + + +E + T+L + ++Q ++E+
Sbjct: 218 EILELKCNLENKKEEVSRLEEQMNGLKTS-NEHLQKHVE---DLLTKLKEAKEQQASMEE 273
Query: 2061 QLE-------KMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113
+ K+ A D E + + + +++L + LK + EVEQ
Sbjct: 274 KFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQ 333
Query: 2114 LANHL-KEKTDKCSEL---------LLSKEQLQRDIQERNE------------EIEKLEF 2151
+ + KE +K L LLS + + I E +I K
Sbjct: 334 SKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGM 393
Query: 2152 RVRELEQALLVSAD--TFQKVEDR---KHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206
++ EL A + + D +K+E++ K+ + + E + L+ +R+ +R +K +
Sbjct: 394 KLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPI-LKRQREEYERAQKAVA 452
Query: 2207 NLEEQLEQFREELENKNEEVQQLHMQ---LEIQKKESTTRLQELEQENKLFKDDMEKL-G 2262
+L +LEQ +E++ E+ + + Q LE + ++++L Q+ ++ ++E+ G
Sbjct: 453 SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512
Query: 2263 LAIKESDAMSTQDQHVLFGKFAQIIQEKEV------EIDQLNEQVTKLQQQLKITTDNKV 2316
+ + +S+ D +++I + V E+ Q N+++ ++L T + +
Sbjct: 513 NHVIRDEEVSSAD----ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE 568
Query: 2317 IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2376
E + I +L+ ++E +++ E ++++R+ +++ ++ ++ + + Q T + +
Sbjct: 569 QETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV---A 625
Query: 2377 LSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE 2436
+ A SL ++ + Q V T E + QL + + K+E
Sbjct: 626 IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE 685
Query: 2437 RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG---S 2493
+ EKIQ N ++ L + +L T+ + + ++ ++N +G
Sbjct: 686 KAENEKIQ-------NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRRE 738
Query: 2494 IINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAA 2553
I +L R +L +T ++ + I M + + E L V + + +EK
Sbjct: 739 ITSLHERNQKLTATTQKQE-------QIINTMTQDLRGANEKLAVAEVRAENLKKEKEML 791
Query: 2554 ALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELES 2613
L S+++L +E Q Q + TN+Q + + E L+ +I +LE
Sbjct: 792 KL-SEVRLSQQRESLLAEQRGQNLL----LTNLQTIQGILERSETETKQRLSSQIEKLEH 846
Query: 2614 QVVEMHTSLILEKEQVEIAEKN----VLEKEKKL-------LELQKLLEGNEKKQREKEK 2662
++ + L E EQ +N +L+ +++L L ++LL+ +K+ ++
Sbjct: 847 EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQ 906
Query: 2663 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVK 2722
S +V+V +++ + S +++ L ++ T+ ++ KE+ + +
Sbjct: 907 HLSNMEVQVASQSSQRTGKGQPSN-KEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQY 965
Query: 2723 ETNMTSLQKDLSQVRDHLAEAKEKLSILEKED-ETEVQESKKACMFEPLPIKLS------ 2775
+ +TSL++ L++ + E ++ + + KE E + Q KK E +L
Sbjct: 966 QAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRA 1025
Query: 2776 -KSIASQTDGTLKISSS--NQTPQILVK-NAGIQINLQSECSSEEVTEIISQFTEKIEKM 2831
+S+ Q K SS N+ + L + + + Q+ +E +I + K E+
Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERE 1085
Query: 2832 QELHAAEILDMES------------RHISETETLKREHYV---------AVQLLKEECGT 2870
LHAA++ +++ +H+ ET T K E + ++LK+E
Sbjct: 1086 LMLHAADVEALQAAKEQVSKMASVRQHLEET-TQKAESQLLECKASWEERERMLKDEVS- 1143
Query: 2871 LKAVIQCLRSKEGSSIPELAHS--DAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGR 2928
K V +C ++ L H + + + S G + ++ EG+
Sbjct: 1144 -KCVCRC---EDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNV--------SLSEEGK 1191
Query: 2929 GEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYI 2988
+E F ++ K + E QV SL + + +Q++ + ER+
Sbjct: 1192 SQEQILEILRFIRREKEIAE-TRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ 1250
Query: 2989 NTISSLKDLITKMQLQREAEVYD-SSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3047
T K + +L ++ E + ++++ + + L LQQ+ + R +
Sbjct: 1251 VT---AKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVR-------KL 1300
Query: 3048 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT 3107
EL L +QE E LQ A+++ L +++ A+ N ++
Sbjct: 1301 ELDIL--------------PLQEANAELSEKSGMLQ-AEKKLLEEDVKRWKAR-NQHLVS 1344
Query: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3167
+++ ++E+ + L E + K+ Q ++ E+ +K L++ + ++ LK +
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQ--QLTEEIGRLKAEIARSNASLTNNQNLIQSLKED 1402
Query: 3168 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE 3227
L + + E ET K+L+A +++++K T+ +K R + E+
Sbjct: 1403 LNKVRTEKETI-------QKDLDAKIIDIQEKV-------KTITQVKKIGRRYKTQYEEL 1448
Query: 3228 KAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQK---IESQRMLY 3284
KA+ + E + D + S ++ +++ K+ LN+++ K +ESQ
Sbjct: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQE--------MQELKETLNQAETKSKSLESQVENL 1500
Query: 3285 DAQLSEE--QGRNLELQ-VLLESEKVRIR-EMSSTLDRERELHAQL-QSSDGTGQSRPPL 3339
LSE+ + RNL+ Q V L+SE R+R ++ +E +L Q+ + + T ++
Sbjct: 1501 QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA 1560
Query: 3340 PSE-----DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR--KTLQ 3392
S+ + +L K+ EE R L + +K +LD T + + + ++ R + L+
Sbjct: 1561 KSKIAHLAGVKDQLTKENEELKQRNGAL--DQQKDELDVRITALKSQYEGRISRLERELR 1618
Query: 3393 TEQEANTEGQKKMHELQSKVEDLQRQLEEK 3422
QE + E + + E +KV + QRQ+ K
Sbjct: 1619 EHQERHLEQRDEPQEPSNKVPEQQRQITLK 1648
Score = 157 bits (397), Expect = 2e-37
Identities = 364/1781 (20%), Positives = 718/1781 (40%), Gaps = 292/1781 (16%)
Query: 694 QLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR-QEEKEKGTLEQEVQELQLKT 752
Q +LE ++L L +S+ N + + Q Q EI+ L+ + EK K EQ+ E++ +
Sbjct: 6 QQVLERTELNKLPKSVQNKLEKFLADQ----QSEIDGLKGRHEKFKVESEQQYFEIEKRL 61
Query: 753 ELLEKQMKEKENDLQEKFAQLEAENSILK---DEKKTLEDMLKIHTPVSQEERLIFLDSI 809
++++ + + Q +LE N+ LK ++ K LE ++R I + S
Sbjct: 62 SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELE---------IAQDRNIAIQSQ 112
Query: 810 KSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYA 869
+++K+ + E E LI NE L Q+ L E++++ K ELQ
Sbjct: 113 FTRTKEEL-EAEKRDLIRTNERLSQELEYLTEDVKRLNEKL----KESNTTKGELQ---- 163
Query: 870 CLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLE 929
LK+ D+L+ S ++ K + K L +E L T + E KT E L
Sbjct: 164 --LKL-DELQAS----DVSVKYREKRLEQEKELLHSQNTWLNT------ELKTKTDELLA 210
Query: 930 MGEVVEKDTTELMEKLEVTKREKLELSQRLSDL--SEQLKQKHGEISFLNEEVKSLKQEK 987
+G + EL LE K E L ++++ L S + QKH E + + LK+ K
Sbjct: 211 LGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVE-----DLLTKLKEAK 265
Query: 988 EQVSLRCRELEIIIN-HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEES 1046
EQ + + +N H + N+ S +T A + K+ K GE +
Sbjct: 266 EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTR----AVEELHKLLKEAGEAN 321
Query: 1047 KIMVEDKVSFENMTVGEESKQEQLI---------LDHLPSVTK-------ESSLRATQPS 1090
K + + + E E + + I + L S TK E L A P+
Sbjct: 322 KAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPT 381
Query: 1091 E---------NDKLQKELNVLKSEQNDLRLQ-MEAQRICLSLVYSTHVDQVREYMENEKD 1140
KL + N Q+ L L+ +E +RI + ++D++ + +E K
Sbjct: 382 AAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI------NKYLDEIVKEVE-AKA 434
Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQ-------K 1193
L +EE AQ+ K+ Q + + QE D+ ++ + K
Sbjct: 435 PILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVK 494
Query: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN-------EDPELQDYR 1246
+S++ L L G + EV++ D +S + IS++ E+ + Q+ R
Sbjct: 495 DLSQQIRVLLMELEEARGNHVIRDE--EVSSADISSSSEVISQHLVSYRNIEELQQQNQR 552
Query: 1247 YEVQ-------DFQENMHTLLNKVTEEYNKL-----------------------LVLQTR 1276
V +E T +K+TE KL +V Q
Sbjct: 553 LLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRD 612
Query: 1277 LSKIWGQQTDGMKLEFGEENL--------PK-----------------EETEFLSIHSQM 1311
+ +I QT G+ + +L PK E TE + + +
Sbjct: 613 MYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL 672
Query: 1312 TNLEDIDVNHKSKLSS---LQDLEKTKLEEQVQELES----------LISSLQQQLKETE 1358
L++I N+K + + +Q+ + KL+EQV +L S S + L++
Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
Query: 1359 QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG 1418
+ Y EI L +R Q ++ +T ++++ A + +N+
Sbjct: 733 EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL-------- 784
Query: 1419 EFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG--GKENTASSKQ 1476
K+E ++KL E + +Q E +A+ + T L I G + T + ++
Sbjct: 785 ----KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLL----TNLQTIQGILERSETETKQR 836
Query: 1477 AHAVCQQEQHYFNEMKLSQDQIGFQTF---ETVDVKFKEEFKPLSKELGEHGKEILLSNS 1533
+ ++ +H + +K + Q +DV+ + + L E H L +
Sbjct: 837 LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
Query: 1534 DPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE 1593
+I K + + ++ S+ + ++ V D QL EEQ+ D+++
Sbjct: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVD--DLVSQLRQTEEQVNDLKER 954
Query: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIK-----RLNRQLAQRSSIDNENL 1648
L +Q QA + +E ++Q+ EE++ RL ++ ++ + +
Sbjct: 955 LKTSTSNVEQ-----YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009
Query: 1649 VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
E+E+ +EL+ K+ ++ E+ EL+ + + QN EV+E +
Sbjct: 1010 EVEKEK---QELQDDKRRAIESMEQQLSELKKTLSSVQN------EVQEALQRASTALSN 1060
Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEV--VKTTAAVEETIGRHVLGILDRSSKSQSS 1766
+ + + A++ N +++L V+ A +E + + +S Q
Sbjct: 1061 EQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSK-------MASVRQHL 1113
Query: 1767 ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE-LSQRL 1825
++E++ EE R+ + + S D+ +++ + E LS ++
Sbjct: 1114 EETTQKAESQLLECKASWEERERMLKDEV---SKCVCRCEDLEKQNRLLHDQIEKLSDKV 1170
Query: 1826 VRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQ 1885
V S G + P N L S + E++LE + + E A+ ES R
Sbjct: 1171 VASVKEGVQ-GPLNVSL-----SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRY 1224
Query: 1886 KQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFE--RQIQEKTD 1943
+Q + +EL++ L+ E + A +++ E ++ + E + ++E+
Sbjct: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEK- 1283
Query: 1944 IIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK 2003
+RLEQ+L ++++LE + +QE LS + ++A E++LL+E K K
Sbjct: 1284 --ERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQA-----EKKLLEEDVKRWK 1336
Query: 2004 EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQAL---EK 2060
+ + +K D ++ + L + E R +L +E ++ + N +L +
Sbjct: 1337 ARNQHLVSQQK--DPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQN 1394
Query: 2061 QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKE 2120
++ +++ L++ ++E + +I +++++K + + + I + E+ LK
Sbjct: 1395 LIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE----LKA 1450
Query: 2121 KTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVE 2180
+ DK E + Q D QE++ +++++ EL++ L A+T K
Sbjct: 1451 QQDKVME---TSAQSSGDHQEQHVSVQEMQ----ELKET-LNQAETKSK----------- 1491
Query: 2181 AKPELSLEVQLQAERDAIDRKEKEITNLEEQ-------LEQFREELENKNEEVQQLHMQL 2233
SLE Q++ + + KE E NL+EQ L + R++L+++ + +QL Q
Sbjct: 1492 -----SLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ- 1545
Query: 2234 EIQKKESTTRLQELEQENKL-----FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ 2288
I +KE TR + ++K+ KD + K +K+ + Q + L + +
Sbjct: 1546 -ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKS 1604
Query: 2289 EKEVEIDQLNEQVTKLQQQLKITTD------NKVIEEKNEL 2323
+ E I +L ++ + Q++ D NKV E++ ++
Sbjct: 1605 QYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQI 1645
Score = 150 bits (379), Expect = 2e-35
Identities = 340/1665 (20%), Positives = 678/1665 (40%), Gaps = 213/1665 (12%)
Query: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
V +++L+ L + KLE+ + + +S I L+ + ++ + E + ++KRL E
Sbjct: 8 VLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67
Query: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNI----DGTIEFSGEF-GVKEETNIVKLLE 1433
V + S+ + + + K + D I +F KEE K
Sbjct: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127
Query: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--AVCQQEQHYFNEM 1491
+ E+L +E+ + + + E + G + QA +V +E+ E
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187
Query: 1492 KLSQDQIGFQTFETVDVKFK-EEFKPLSKELG----------EHGKEIL---------LS 1531
+L Q T+ ++K K +E L +E G E+ KE + L
Sbjct: 188 ELLHSQ---NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLK 244
Query: 1532 NSDPHDIPESKDCVLTI---SEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLE 1588
S+ H +D + + E+ S ++ F + H ++S A+ +L
Sbjct: 245 TSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT 304
Query: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRLNRQLAQRSSIDNEN 1647
+EL + +E +A + + Q H+ ++E+ ++ E ++ E+I RL ++L + + +
Sbjct: 305 RAVEELHKLLKEAGEANKAI-QDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS-- 361
Query: 1648 LVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN-ENQGEVEEQTFKEKELD 1706
++R+ +L E E A + T+ N E Q ++ + + K ++
Sbjct: 362 -ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
Query: 1707 RKPEDVPPE------ILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
+ +++ E IL +R ++A + + VK A++E + + + +
Sbjct: 421 KYLDEIVKEVEAKAPILKRQREEYERAQKAVASL---SVKLEQAMKE-----IQRLQEDT 472
Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820
K+ +S++ R ++ + RV + G+ + R++ + ++
Sbjct: 473 DKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEV 532
Query: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880
+SQ LV N E + + RL A+ +L E + +K+T+ +L
Sbjct: 533 ISQHLV---------SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKL 583
Query: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI----DGYADEKTLFER 1936
ES E + K ++ + + R R+ + LS+ GV D+ +L
Sbjct: 584 ES--ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
Query: 1937 QIQEKT-DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL 1995
+ T + + S E +A +Q+QE E ++ KAE ++ + L
Sbjct: 642 PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE----KAENEKIQNEQL 697
Query: 1996 QETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI--DVEEQVSRFIELEQEKNTELMDLRQ 2053
EKL ++ +++ Q K+ L K E+ D E R I E+N +L Q
Sbjct: 698 ---EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
Query: 2054 -QNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVE 2112
Q Q + + +R ++ A+ +V + ++K ++ LK+ + R +
Sbjct: 755 KQEQIINTMTQDLRGANEKLAV-----AEVRAENLKKEKEMLKL---------SEVRLSQ 800
Query: 2113 QLANHLKEKTDKCSELLLSKEQLQRDIQERNE---------EIEKLEFRVRELEQALLVS 2163
Q + L E+ + LLL+ Q + I ER+E +IEKLE + L++ L
Sbjct: 801 QRESLLAEQ--RGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENE 858
Query: 2164 ADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-RDAIDRKEKEITNLEEQLEQFREELENK 2222
+ + ++ K +L E L ++ + +KEI L++ L E++
Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM--EVQVA 916
Query: 2223 NEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA---IKESDAMSTQDQHVL 2279
++ Q+ K++ + +L Q + D E+L + +++ AM T + L
Sbjct: 917 SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976
Query: 2280 FGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQE 2339
K Q+ +E I+ ++ + Q QL+ +V +EK EL D IE +
Sbjct: 977 -NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL-MEVEKEKQELQDDKRRAIESM----- 1029
Query: 2340 CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2399
E+++ +L + + +Q E+ Q+ S +LS E + + D K+A+E
Sbjct: 1030 ------EQQLSELKKTLSSVQNEVQEALQRAST---ALSNEQQARR---DCQEQAKIAVE 1077
Query: 2400 QQVETANEEMTFMKNV-----LKETNFKMNQLTQELFSLKRERES-VEKIQSIPENSVNV 2453
Q + E M +V KE KM + Q L ++ ES + + ++ E +
Sbjct: 1078 AQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137
Query: 2454 AIDHLSK-----DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTV 2508
D +SK + E + L D ++ L ++ S +E +G +N+ L E
Sbjct: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV-VASVKEGVQGP-LNVS---LSEEGKS 1192
Query: 2509 SAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV 2564
+ LE+ + ++ K++ E Q E+ ++++ L++ ++E + + E V
Sbjct: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSL---NAEREKV 1249
Query: 2565 QEYAKFCQDNQTISSEPERTNI--QNLNQLREDE--LGSDISALTLRISELESQVVEMHT 2620
Q AK ++ + + E N+ + LRE++ L D+ + ++ +LE +
Sbjct: 1250 QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI----- 1304
Query: 2621 SLILEKEQVEIAEKN-VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTEL- 2678
L L++ E++EK+ +L+ EKKLLE + + + Q +++ P E K +E
Sbjct: 1305 -LPLQEANAELSEKSGMLQAEKKLLE-EDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKE 1362
Query: 2679 FHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDL----- 2733
H+ E+ L+AE + A L + + + L+E+L T ++QKDL
Sbjct: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
Query: 2734 ---------SQVR-----------------DHLAEAKEKLSILEKEDETEVQESKKACMF 2767
+QV+ D + E + S +E VQE ++
Sbjct: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
Query: 2768 EPLPIKLSKSIASQTDGTLKISS---------SNQTPQILVKNAGIQINLQSECSSEEVT 2818
SKS+ SQ + K S QT Q+ + + ++ +LQ + EE
Sbjct: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEE-- 1540
Query: 2819 EIISQFTEKIEKMQEL------HAAEILDMESRHISETETLKREH 2857
++ Q TEK EK ++ A + ++ + E E LK+ +
Sbjct: 1541 QLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRN 1585
Score = 149 bits (377), Expect = 4e-35
Identities = 375/1821 (20%), Positives = 748/1821 (41%), Gaps = 313/1821 (17%)
Query: 554 QESKLNEAHKSLST-----VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN 608
+ ++LN+ KS+ + D ++EI + R E + K E+E ++I+ + ++
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEI-DGLKGRHE-KFKVESEQQYFEIEKRLSHSQER 67
Query: 609 AVLD-RMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQI 667
V + R +S ELE+L QL + L++ ++LEI NI
Sbjct: 68 LVNETRECQSLRLELEKLNNQL-----KALTEKNKELEIAQDRNI--------------- 107
Query: 668 DGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL----KDLQQSLVNSKSE--EMTLQI 721
+Q++ ++ E ++ EK +LI +L E+ L K L + L S + E+ L++
Sbjct: 108 -AIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKL 166
Query: 722 NELQKEIEILRQEEKEKGTLEQEVQ-----------ELQLKTELLEKQMKEKENDLQEKF 770
+ELQ ++ EK LEQE + EL+ KT+ L +EK N++ E
Sbjct: 167 DELQASDVSVKYREKR---LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELK 223
Query: 771 AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830
LE + K+E LE+ + K+ + +K +E L+ + +
Sbjct: 224 CNLENK----KEEVSRLEEQMN-----------------GLKTSNEHLQKHVEDLLTKLK 262
Query: 831 DLKQQCIQLNEEIE-------KQRNTFSFAEKNFEVNYQELQ---EEYACLLK------- 873
+ K+Q + E+ K N + A + E EL EE LLK
Sbjct: 263 EAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK 322
Query: 874 -VKDDL---EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLE 929
++D L E SK++ E E K+ L +EL + K K ++ E++ +A
Sbjct: 323 AIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEE--LAAMSP 380
Query: 930 MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989
V K M KL +E +L L E+L+ K +L+E VK + + K
Sbjct: 381 TAAAVAKIVKPGM-KLTELYNAYVETQDQL--LLEKLENKRIN-KYLDEIVKEV-EAKAP 435
Query: 990 VSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM 1049
+ R RE E Q +S L+ + R E + K NK +S ++
Sbjct: 436 ILKRQRE--------EYERAQKAVASLSVKLEQAMKEIQRLQEDT-DKANK----QSSVL 482
Query: 1050 VEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV---LKSEQ 1106
D E + V + S+Q +++L L +R + S D + L S +
Sbjct: 483 ERDNRRME-IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR 541
Query: 1107 NDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI-- 1164
N LQ + QR+ ++L ++ E E E+ + S EL E + EL+++
Sbjct: 542 NIEELQQQNQRLLVAL------RELGETREREEQETTSSKITELQLKLESALTELEQLRK 595
Query: 1165 ---HQLEL-----------QTMKTQETGDEGKPLHLL-IGKLQKAVSEECSYFLQTLCSV 1209
HQ++L + + +Q TG PLH + + A + + QT+
Sbjct: 596 SRQHQMQLVDSIVRQRDMYRILLSQTTG-VAIPLHASSLDDVSLASTPKRPSTSQTVS-- 652
Query: 1210 LGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNK 1269
TPA + + + + + + ++ ++Y+ E + ++ + L K+ E+
Sbjct: 653 -----TPAPVPVIESTEAIEAKAALKQLQEI-FENYKKEKAENEKIQNEQLEKLQEQVTD 706
Query: 1270 LLVLQTRLSKIWGQQTD--GMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSS 1327
L T++S Q D + E ++N+ E S+H + L + +++
Sbjct: 707 LRSQNTKIST----QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT 762
Query: 1328 L-QDL--------------EKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL 1372
+ QDL E K E+++ +L + S Q++ EQ + + + +
Sbjct: 763 MTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTI 822
Query: 1373 QAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIE-------------FSGE 1419
Q + E + ++ S ++ + S +KK ++ +E +
Sbjct: 823 QGILERS-----ETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877
Query: 1420 FGVKEETNIVKLLEKQYQEQLEEEVAKV---IVSMSIAFAQQTELSRISGGKENTASSKQ 1476
+ ETN+ L K+ + ++E+A + + +M + A Q+ G N
Sbjct: 878 RQLDTETNL-HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDD 936
Query: 1477 AHAVCQQEQHYFNEMK--LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSD 1534
+ +Q + N++K L + ++ + +E + E K I +
Sbjct: 937 LVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR--- 993
Query: 1535 PHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL 1594
+ ES + + +++ +K +Q + D D R + E+QL ++++ L
Sbjct: 994 ---LKESAEFQTQLEKKLMEVEKE---KQELQD-------DKRRAIESMEQQLSELKKTL 1040
Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERER 1654
E Q+A + A + + +R+ QEQ + ++ N+ ERE
Sbjct: 1041 SSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKY--------------EREL 1086
Query: 1655 VL-LEELEALKQLSLAGREKL--CCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPED 1711
+L ++EAL+ A +E++ +R +T E+Q + +++E+E K ++
Sbjct: 1087 MLHAADVEALQ----AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK-DE 1141
Query: 1712 VPPEILSNERYALQKANNRLLKILLEVV--KTTAAVEETIGRHVLGILDRSSKSQSSASL 1769
V + E Q NRLL +E + K A+V+E + + L KSQ
Sbjct: 1142 VSKCVCRCEDLEKQ---NRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILE 1198
Query: 1770 IW---RSEAE--------ASVKSCVHEEHTRVTDESIPSYSGS-DMPRNDINMWSKVTEE 1817
I R E E A V+S + + + + + S + R + + +K +
Sbjct: 1199 ILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQ 1258
Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
EL ++ E +++ + L+ E+L E Q AKV + E
Sbjct: 1259 HEELMKK------------TETMNVVMETNKMLREEKERL-----EQDLQQMQAKVRKLE 1301
Query: 1878 L----MRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVID--GYADEK 1931
L ++E+ + E + L+ +++L E + +AR Q V K + EK
Sbjct: 1302 LDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEK 1361
Query: 1932 TLFERQIQEKTDIIDRLEQELLCAS-------NRLQELEAEQQQIQEERELLSRQKEAMK 1984
+ ++IQ+ T+ I RL+ E+ ++ N +Q L+ + +++ E+E + + +A
Sbjct: 1362 EVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKI 1421
Query: 1985 AEAGPVEQQLLQETE-KLMKEKLEVQCQAEKVRDDLQKQVKALEI-DVEEQVSRFIELEQ 2042
+ +++++ T+ K + + + Q + K + D + A D +EQ E+++
Sbjct: 1422 ID---IQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQE 1478
Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102
K T L ++++LE Q+E ++K L E +E E Q++ +L+ +L R +
Sbjct: 1479 LKET-LNQAETKSKSLESQVENLQKTLSE----KETEARNLQEQTVQLQSELS---RLRQ 1530
Query: 2103 ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162
+ +T + EQL + EK +K + +++ + + +++ K
Sbjct: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTK-------------- 1576
Query: 2163 SADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENK 2222
+ E ++ GA++ + + L+V++ A + + E I+ LE +L + +E +
Sbjct: 1577 -----ENEELKQRNGALDQQKD-ELDVRITALK---SQYEGRISRLERELREHQERHLEQ 1627
Query: 2223 NEEVQQLHMQLEIQKKESTTR 2243
+E Q+ ++ Q+++ T +
Sbjct: 1628 RDEPQEPSNKVPEQQRQITLK 1648
Score = 140 bits (353), Expect = 2e-32
Identities = 344/1771 (19%), Positives = 707/1771 (39%), Gaps = 293/1771 (16%)
Query: 1509 KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCV-LTISEEMFSKDKTFIVRQSIHD 1567
KFK E + E+ E LS+S + E+++C L + E + + ++
Sbjct: 45 KFKVESEQQYFEI-----EKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL 99
Query: 1568 EISVS-SMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQL 1626
EI+ ++ Q +E+LE +++L+ R ER ++ E L
Sbjct: 100 EIAQDRNIAIQSQFTRTKEELEAEKRDLI------------------RTNERLSQELEYL 141
Query: 1627 QEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQ 1686
E++KRLN +L + ++ E ++ L+EL+A +S+ REK E +Q
Sbjct: 142 TEDVKRLNEKLKESNTTKGE------LQLKLDELQA-SDVSVKYREKR-LEQEKELLHSQ 193
Query: 1687 NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVE 1746
N N E++ +T + L R+ + E+ N ++ + L+ + +KT+
Sbjct: 194 NTWLNT-ELKTKTDELLALGREKGNEILELKCNLENKKEEVSR--LEEQMNGLKTS---N 247
Query: 1747 ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE---HTRVTDESIPSYSGSDM 1803
E + +HV +L + +++ E +AS++ H E H ++++ + S+
Sbjct: 248 EHLQKHVEDLLTKLKEAK---------EQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
Query: 1804 PRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863
N++ T EL + L +G A I ++ +L + +++LE I
Sbjct: 299 KSNEL------TRAVEELHKLLKEAGEANKAI----QDHLLEVEQSKDQMEKEMLEKIGR 348
Query: 1864 TSSQLEHAKVTQTELMRESFRQKQE-----------ATESLKCQEELRERLHEESRAREQ 1912
+LE+A + R+ +E + +K +L E + ++Q
Sbjct: 349 LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
Query: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE 1972
L +E + + I+ Y DE ++++ K I+ R +E A + L + +Q +E
Sbjct: 409 LLLEKLENKR-INKYLDE---IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKE 464
Query: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032
+ L + ++ +E+ ++E+Q + DL +Q++ L +++EE
Sbjct: 465 IQRLQEDTDKANKQSSVLERD---------NRRMEIQVK------DLSQQIRVLLMELEE 509
Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092
+ ++E ++ D+ ++ + + L R +E+Q+ Q
Sbjct: 510 ARGNHVIRDEEVSS--ADISSSSEVISQHLVSYRNI----------------EELQQQNQ 551
Query: 2093 QLKVVPRFQPISEHQTR-EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151
+L V R + E + R E E ++ + E K L EQL++ Q + + ++ +
Sbjct: 552 RLLVALR--ELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSI-V 608
Query: 2152 RVRELEQALL-----VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE---- 2202
R R++ + LL V+ D + +P S V A I+ E
Sbjct: 609 RQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEA 668
Query: 2203 -KEITNLEEQLEQF-REELEN---KNEEVQQLHMQ---LEIQKKESTTRLQELEQENKLF 2254
+ L+E E + +E+ EN +NE++++L Q L Q + +T+L + ++
Sbjct: 669 KAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEML 728
Query: 2255 KDDMEKLGLAI------KESDAMSTQDQHVLFGKFAQIIQ---EKEVEIDQLNEQVTKLQ 2305
+D++E I + +TQ Q + Q ++ EK + E + K +
Sbjct: 729 QDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788
Query: 2306 QQLKITTDNKVIEEKNELIRDLETQ---IECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362
+ LK+ ++ ++ +++ L+ + Q + L + Q ++R+ E ++L+ IEKL+ E
Sbjct: 789 EMLKL-SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE 847
Query: 2363 LANIGQKTSMNA---HSLSEEAD----SLKHQLDVVIAEKLALEQQVETANEEMTFMK-- 2413
++++ +K H+L+ D K QLD L ++ ++ A +E+ +K
Sbjct: 848 ISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH 907
Query: 2414 -------------------------------NVLKETNFKMNQLTQELFSLKRERESVEK 2442
+ L++T ++N L + L + E +
Sbjct: 908 LSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQA 967
Query: 2443 IQSIPENSVNVAIDHLSKDKPELEVVLTEDA-------LKSLENQTYFKSFEENGKGSII 2495
+ + E S+N + + +EV L E A K +E + + +++ + +I
Sbjct: 968 MVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIE 1027
Query: 2496 NLETRLLQLESTVSAKDLELTQCYKQIK---DMQEQGQFETEMLQKKIVNLQKIVEEKVA 2552
++E +L +L+ T+S+ E+ + ++ ++Q + + + K V Q E ++
Sbjct: 1028 SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELM 1087
Query: 2553 --AALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLN-----QLREDELGSDISALT 2605
AA V +Q A ++ +K Q + ++ Q L + RE L ++S
Sbjct: 1088 LHAADVEALQ-AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV 1146
Query: 2606 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2665
R +LE Q +H + ++V + K E + L + EG ++Q + +
Sbjct: 1147 CRCEDLEKQNRLLHDQIEKLSDKVVASVK---EGVQGPLNVSLSEEGKSQEQILEILRFI 1203
Query: 2666 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE-----KLQEELL 2720
++ E+ +T E+ E + +E L E + L + +EK + Q E L
Sbjct: 1204 RREKEIAETRFEVAQV-ESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEEL 1262
Query: 2721 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIAS 2780
+K+T ++ + +++ L E KE+L ++D ++Q + + LP++ + + S
Sbjct: 1263 MKKTETMNVVMETNKM---LREEKERL----EQDLQQMQAKVRKLELDILPLQEANAELS 1315
Query: 2781 QTDGTLKISSSNQTPQILVKNAGIQ--INLQSECSSEEVTEIISQFTEKIEKMQELHAAE 2838
+ G L+ + A Q ++ Q + +EE +++S+
Sbjct: 1316 EKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSE--------------- 1360
Query: 2839 ILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT- 2897
K H +Q L EE G LKA E+A S+A T
Sbjct: 1361 ---------------KEVHTKRIQQLTEEIGRLKA--------------EIARSNASLTN 1391
Query: 2898 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNE-GMQ 2956
+ D + + D+ ++ + + T + KKI + + E Q
Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451
Query: 2957 VLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI----SSLKDLITKMQLQREAEVYDS 3012
+ E+ DH Q VS ++E K +N SL+ + +Q + ++
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 3013 SQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQG 3072
E + EL Q L++R+ R ++T ++ + G
Sbjct: 1512 RNLQEQTVQLQSELSRLRQD--LQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAG 1569
Query: 3073 VEYQAAMECLQKADRRSLLSE--------IQALHAQMNGRKITLKREQESEKPSQELLEY 3124
V+ Q E + R L + I AL +Q GR L+RE
Sbjct: 1570 VKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERE------------- 1616
Query: 3125 NIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
+++ Q + LE + E ++ E Q Q++
Sbjct: 1617 -LREHQERHLEQRDEPQEPSNKVPEQQRQIT 1646
Score = 135 bits (340), Expect = 8e-31
Identities = 212/1010 (20%), Positives = 425/1010 (42%), Gaps = 145/1010 (14%)
Query: 135 REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQ 194
R ++ EQ L +LA + E L +E E ++++ ++ Q
Sbjct: 745 RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSE----VRLSQ 800
Query: 195 EFEAAIKQRDGIITQLTANLQ--QARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETL 251
+ E+ + ++ G LT NLQ Q E+ ET + L+ Q +KL+ + L+ E
Sbjct: 801 QRESLLAEQRGQNLLLT-NLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858
Query: 252 RNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVY 308
H+ T LL K+Q+ T LL++ QK+ +S ++ ++
Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
Query: 309 EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQ 368
++ K + SNKE+ +++L +++ + E++ +LK++L T+ + + Q +
Sbjct: 919 SSQRTGKGQPSNKED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT- 970
Query: 369 KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR 428
L S KE+Q +EE++ + ++ R + ++F+T + +++
Sbjct: 971 ----------SLEESLNKEKQVTEEVR------KNIEVRLKESAEFQTQLEKKL-----M 1009
Query: 429 KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI 488
++E+ + EL + + I M+Q+L +++++ + + E++ AL+ S NE Q
Sbjct: 1010 EVEKEKQELQDDKRRAIESMEQQL-----SELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
Query: 489 KLMNVAINELNIKLQDTNSQKEKLK------EELGLILEEKCALQRQLEDLVEELSFSRE 542
+ + I ++ N + +L E L E+ + + L E +
Sbjct: 1065 R--RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
Query: 543 QIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Q+ + + E+E L +E K + EDL+ + + ++L K A V E
Sbjct: 1123 QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVK------E 1176
Query: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
++ N L +SQE LE LR E+E++ E R + +++ +
Sbjct: 1177 GVQGPLNVSLSEEGKSQEQILEILR---FIRREKEIA--------ETRFEVAQVE---SL 1222
Query: 662 HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI 721
Y+Q+++ L+ E+ + +++ E++ ++++ Q + K+E M + +
Sbjct: 1223 RYRQRVELLERELQELQDSLNAEREK---------VQVTAKTMAQHEELMKKTETMNVVM 1273
Query: 722 NELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781
E + +EEKE+ LEQ++Q++Q K LE + LQE A+L ++ +L+
Sbjct: 1274 -----ETNKMLREEKER--LEQDLQQMQAKVRKLELDIL----PLQEANAELSEKSGMLQ 1322
Query: 782 DEKKTLEDMLKIHTP-----VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK--- 833
EKK LE+ +K VSQ++ + K S+ V K I+ L EE LK
Sbjct: 1323 AEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382
Query: 834 ----------QQCIQ-LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882
Q IQ L E++ K R +K+ + ++QE+ + +VK K
Sbjct: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442
Query: 883 NKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942
+ E +LKA +++ + + V ++ + ETL E K +
Sbjct: 1443 TQYE-----ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV 1497
Query: 943 EKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE---- 998
E L+ T EK +L EQ Q E+S L ++++ ++EQ+ + E E
Sbjct: 1498 ENLQKTLSEK---ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
Query: 999 --IIINHNRAENVQSCDTQVS-----------------SLLDGVVTMTSRGAEGSVSKVN 1039
I+ ++ ++ Q++ LD +T EG +S++
Sbjct: 1555 KAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLE 1614
Query: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089
+ E + +E + + + +Q Q+ L P+ + + P
Sbjct: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDP 1664
Score = 129 bits (324), Expect = 6e-29
Identities = 314/1499 (20%), Positives = 619/1499 (41%), Gaps = 195/1499 (13%)
Query: 2304 LQQQLKITTDNKV---IEEKNE-LIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2359
LQQ L+ T NK+ ++ K E + D +++I+ L E K E++ ++ + +
Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
Query: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQL----------DVVIAEKLALEQQVETANEEM 2409
Q+ L N + SL E + L +QL ++ +A++ Q EE+
Sbjct: 65 QERLVN----ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
Query: 2410 TFMKNVLKETNFKMNQLTQELFSLKRERESVEKI-QSIPENSVNVAIDHLSKDKPELEVV 2468
K L TN +L+QEL L E V+++ + + E++ L D+ + V
Sbjct: 121 EAEKRDLIRTN---ERLSQELEYLT---EDVKRLNEKLKESNTTKGELQLKLDELQASDV 174
Query: 2469 LTEDALKSLENQTYFKSFEENGKGSIINLET-RLLQLESTVSAKDLELTQCYKQIKDMQE 2527
+ K LE + + + + +T LL L + LEL +C + K +E
Sbjct: 175 SVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILEL-KCNLENKK-EE 232
Query: 2528 QGQFETEMLQKKIVN--LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTN 2585
+ E +M K N LQK VE+ + ++ Q +++E KF +
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE--KFHNELNA------HIK 284
Query: 2586 IQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2645
+ NL + D+ + + +EL V E+H L E + + ++LE E+ +
Sbjct: 285 LSNLYKSAADDSEA-------KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
Query: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL 2705
++K E EK R +++ + D+ S EE + A A+ V +L
Sbjct: 338 MEK--EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL 395
Query: 2706 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2765
+ Q++LL+++ + K L ++ + E + K IL+++ E E + ++KA
Sbjct: 396 TELYNAYVETQDQLLLEKLENKRINKYLDEI---VKEVEAKAPILKRQRE-EYERAQKAV 451
Query: 2766 MFEPLPIKLSKS------IASQTDGTLKISS----SNQTPQILVKNAGIQIN-LQSECSS 2814
L +KL ++ + TD K SS N+ +I VK+ QI L E
Sbjct: 452 A--SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509
Query: 2815 EEVTEIISQFTEKIEKMQELHAAEILD---MESRHISETETLKREHYVAVQLL-----KE 2866
+I E++ ++E++ + R+I E + + VA++ L +E
Sbjct: 510 ARGNHVIRD--EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRERE 567
Query: 2867 ECGTLKAVIQCLRSKEGSSIPELAH---SDAYQTREICSSDSGSDWGQGIYLTHSQGFDI 2923
E T + I L+ K S++ EL S +Q + + S D + I L+ + G I
Sbjct: 568 EQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYR-ILLSQTTGVAI 626
Query: 2924 ASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEE 2983
+ S S PK+ + V+ TE+ + +Q++ E + +E
Sbjct: 627 PLHASSLDDVSLA-STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE 685
Query: 2984 RKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLA 3043
+ + I QL++ E +S + ++ Q F +R +L
Sbjct: 686 KAE--------NEKIQNEQLEKLQEQVTDLRSQNT--------KISTQLDFASKRYEMLQ 729
Query: 3044 ----AFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA 3099
+R E+T+L + L Q+Q + L+ A+ + ++E++A +
Sbjct: 730 DNVEGYRREITSLHERNQK-----LTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
Query: 3100 QMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA-TELQEQLSSEK 3158
+ + L + S++ L E Q+ Q+ +L + + +R+ TE +++LSS+
Sbjct: 785 KKEKEMLKLSEVRLSQQRESLLAE---QRGQNLLLTNLQTIQGILERSETETKQRLSSQ- 840
Query: 3159 MVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD---EVHL-LNDTLASEQ 3214
+ +L+ E++ K +LE ++ +H + L+ L+ K + D +HL + L + Q
Sbjct: 841 --IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQ 898
Query: 3215 KKSRELQWALEKEKAKL--------GRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3266
K+ L+ L + ++ G+ + +KE+++DL L +++ L L+
Sbjct: 899 KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTS 958
Query: 3267 KQLLNESQQKIES--QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHA 3324
+ + Q + S + + + Q++EE +N+E++ L ES + + + ++ E+E
Sbjct: 959 TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR-LKESAEFQTQLEKKLMEVEKEKQ- 1016
Query: 3325 QLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDR 3384
+LQ ++ +++QL E + + NE + ++LQ +
Sbjct: 1017 ELQDD-----------KRRAIESMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNE 1061
Query: 3385 QVHRKTLQTEQEANTEGQKKMH-ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF 3443
Q R+ Q + + E Q K EL D++ L+ ++QV K+ Q L+ Q+
Sbjct: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEA-LQAAKEQVSKMASVRQHLEETTQKA 1120
Query: 3444 QKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE-------GETKESNYA 3496
+ Q LE + E R + ++ +N +L +IE KE
Sbjct: 1121 ESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQG 1180
Query: 3497 KL-IEMNGGGTGCNHELEM---IRQKLQCVASKLQVLP------QKASERLQFETADDED 3546
L + ++ G LE+ IR++ + ++ +V ++ E L+ E + +D
Sbjct: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
Query: 3547 FIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAE------------ 3594
+ N + +Q+ T Q EE + + + T ++LR+ E
Sbjct: 1241 SL----NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAK 1296
Query: 3595 ----------LTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANI 3644
L ++L+E+ L+ LEE ++ ++ N S +
Sbjct: 1297 VRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR-----NQHLVSQQKDPDT 1351
Query: 3645 EAI--IASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL-RNDSLLQTLSPDSEHVTLKR 3700
E + SEKEV + L + + R +AE+ + A L N +L+Q+L D V ++
Sbjct: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEK 1410
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 179 bits (453), Expect = 6e-44
Identities = 350/1771 (19%), Positives = 727/1771 (41%), Gaps = 190/1771 (10%)
Query: 6 RQKKLEAGKAKLAQFRQR----KAQSDGQSPSKKQKKKRKTSSSK------HDVSAHHDL 55
+QK++E K Q + K QS QS T+SS H SA HD
Sbjct: 101 QQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDD 160
Query: 56 NID-------QSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEIS 108
++D Q + N + N R+ES V I +T + + +Q +L++ I
Sbjct: 161 DMDFGDIISSQQEINRLS-NEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIK 219
Query: 109 TTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELA-GK 167
+ S E++ M + N +++ + + E+ D +E +E+ L G
Sbjct: 220 ELKQNRSQEIDDHQHEMSVLQ--NAHQQKLTEISRRHREE-LSDYEERIEELENLLQQGG 276
Query: 168 QHEIEELNRELEEMRVTYGT------EGLQQLQEFEAAIKQRDGIITQLTANLQQARREK 221
IE ++ EM+ T E +++++ E IK + ++ + RRE+
Sbjct: 277 SGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQ 336
Query: 222 DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK--QQILTHQQQLEE 279
++ E ++ E+ + L+++ +LQ S ++ T + L Q+ +++ QQ L +
Sbjct: 337 EQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSD 396
Query: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ--------EKETII 331
++ + +D ++ L+ K+++ +E++K + + KEE+Q E E I
Sbjct: 397 AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK 456
Query: 332 E----------ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381
EL+ + E K EL ++ + L+ E++E Q + K+M L
Sbjct: 457 STATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKD 516
Query: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
+++ + I +L + + +KR H+ + DI + ++ + + KL Q L++++
Sbjct: 517 QLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKE-KLIQSEVALNDLH 575
Query: 442 GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNI 500
+ Q ++ + + Q+ + + + + L +I NE+++ ++ N + LN
Sbjct: 576 LTK--QKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLN- 632
Query: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
QD+NS K+ L L+E+ A R L+ + EL E +++ + + KL
Sbjct: 633 --QDSNSN---FKDTL---LKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL-- 682
Query: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE----KNAVLDRMAE 616
+ ED++ ++ +L L+ V K++ +E E K +L+ A
Sbjct: 683 ----VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEE-AN 737
Query: 617 SQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ 676
E +E L S+ L+ LE EH I + + KD K+ I+ + + +
Sbjct: 738 KYEKTIEEL------SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE 791
Query: 677 KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK 736
+ + + + +Q QL I+K + + L K LQ EL K + LR+ E
Sbjct: 792 TKDVLS----SSLEEQKQLTQLINKKEIFIEKL---KERSSKLQ-EELDKYSQALRKNEI 843
Query: 737 EKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIH 794
+ T+E++ + L MKE+ N LQE+ +L E S + KTL+ + ++
Sbjct: 844 LRQTIEEKDRSLG--------SMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELA 895
Query: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
+ VSQ L++IK ++ + K + +IE+ K Q +Q +E +K+ + F +
Sbjct: 896 SEVSQ------LNTIKEHLEEEI--KHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQH 947
Query: 855 KNFEVNYQEL----QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTV 910
+ + +L EE L K + ++ +++ + ++ + +E +Q +N
Sbjct: 948 EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENG 1007
Query: 911 KMKSSVFDED-----KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ 965
K + + K LE+ + EK+ + + +++K E +L+Q + +
Sbjct: 1008 SEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLE 1067
Query: 966 LKQKHGEISFLN--EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGV 1023
++ H IS + ++V L+Q+ + ++ ++ ++N EN T+ ++D V
Sbjct: 1068 IQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN-SHLKTEYHKMMDIV 1126
Query: 1024 VTMTSR--GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE-------SKQEQLILDH 1074
+ + K++ F + M + + + + E+ S++ Q +L
Sbjct: 1127 AAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAV 1186
Query: 1075 LPSVTKESSLRATQPSENDKLQKELNVLKSE--------QNDLRLQMEAQRICLSLVYST 1126
L + + + ++ ++L +E + LK + Q + Q L
Sbjct: 1187 LQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL 1246
Query: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
H Q + ++++ + L LI + E+ +L+ Q Q + G L
Sbjct: 1247 HQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHS--IGQLCNTKDL 1304
Query: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
L+GKL + S L T S A K EV +E E + E LQ+
Sbjct: 1305 LLGKLDIISPQLSSASLLTPQSA---ECLRASKSEVLSESSELLQQELEELRK-SLQEKD 1360
Query: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-----ENLPKEE 1301
++ QEN H L + + + L + +QTD + E + L KE+
Sbjct: 1361 ATIRTLQENNHRLSDSIAAT--------SELERKEHEQTDSEIKQLKEKQDVLQKLLKEK 1412
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
+ S + + +K + L T L+E++ LE I L+ + ++ + Y
Sbjct: 1413 DLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY 1472
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPV-DSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEF 1420
+ + QA+ E+ + S+ + + S ++ + +K+ G +GE
Sbjct: 1473 RGK----ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGK---TGE- 1524
Query: 1421 GVKEETNIVKLLEKQ---YQEQLEEEVAKVIVSMSIAFAQQTELSRISGG--KENTASSK 1475
+ + N VK ++++ +Q++ ++ + + A Q E+ R+ + N +
Sbjct: 1525 -LNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELER 1583
Query: 1476 QAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDP 1535
+ + + E Y E ++D+ + K +++ L ++L + SN+
Sbjct: 1584 LRNHLLESEDSYTREALAAEDR---------EAKLRKKVTVLEEKL------VSSSNAME 1628
Query: 1536 HDIPESKDCVLTISEEMF----SKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMR 1591
+ ++ V ++ E++ +D+T + +++ ++ + M+ LE +
Sbjct: 1629 NASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMV----LEHFQ 1684
Query: 1592 QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSE 1651
QE Y + + L + E LQE + N L S + + V E
Sbjct: 1685 QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKE 1744
Query: 1652 RERVLLEELEALKQLSLAGREKLCCELRNSS 1682
+ L+ L+Q L +K L NSS
Sbjct: 1745 EQIEELKRQNELRQEMLDDVQKKLMSLANSS 1775
Score = 170 bits (431), Expect = 2e-41
Identities = 362/1744 (20%), Positives = 735/1744 (42%), Gaps = 269/1744 (15%)
Query: 1832 GTEIDPENEELML-NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEAT 1890
GT+ ++E L NI L+ + ++ S L++A Q +L S R ++E +
Sbjct: 202 GTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAH--QQKLTEISRRHREELS 259
Query: 1891 ESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ 1950
+ + EEL L + + +LSK Y +KT+ QI EK + ++EQ
Sbjct: 260 DYEERIEELENLLQQGGSG--VIETDLSKI------YEMQKTIQVLQI-EKVESTKKMEQ 310
Query: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010
++++++ + + +R++L R++E + E ++Q+++E E L E ++Q
Sbjct: 311 ----LEDKIKDINKKLSSAENDRDILRREQEQLNVE----KRQIMEECENLKLECSKLQP 362
Query: 2011 QAEKVRDDLQKQVKALEIDVE-EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
A K D + ++ + L E+V R + + E+M L NQ + ++ +
Sbjct: 363 SAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM 422
Query: 2070 DEQAIDREHERDVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2128
+ +++E + + QE ++L+ L K+ ++ I TR++ SEL
Sbjct: 423 RIEVLEKE--KSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISL-----------DSEL 469
Query: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLE 2188
+ L+ QE N+ I + E + E+E+ Q E KH + K +LS +
Sbjct: 470 HDLRLNLEAKEQELNQSISEKETLIAEIEEL------DRQNQEATKHM--ILIKDQLSKQ 521
Query: 2189 VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK---ESTTRLQ 2245
Q E D+I I+ L++ L ++ + ++ + +L++QK+ +S L
Sbjct: 522 ---QNEGDSI------ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALN 572
Query: 2246 ELEQENKLFKDDMEKLGLAIKESDA--MSTQDQHVLFGKFAQIIQEKEVEIDQL-NEQVT 2302
+L + +D +E L + +S +S Q +++ + + I++ E E+ ++ NE +
Sbjct: 573 DLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENL---ELKEHIRQNEEELSRIRNELMQ 629
Query: 2303 KLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362
L Q + +++E+ +R+L+ + E+EQLNE ++K+ +
Sbjct: 630 SLNQDSNSNFKDTLLKEREAEVRNLKQNLS---------------ELEQLNENLKKVAFD 674
Query: 2363 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET-NF 2421
+ M L + ++HQL+ +A N +++ KN + ET
Sbjct: 675 V-------KMENEKLVLACEDVRHQLEECLA-----------GNNQLSLEKNTIVETLKM 716
Query: 2422 KMNQLTQEL-FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ 2480
+ ++ EL ++ KR E K + E N + S + E E ++ + K +E
Sbjct: 717 EKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIA 776
Query: 2481 TYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI 2540
K+ E+ ++T + + +S+ E KQ+ + + + E L+++
Sbjct: 777 ELKKNIEQ--------MDTDHKETKDVLSSSLEE----QKQLTQLINKKEIFIEKLKERS 824
Query: 2541 VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN-LNQLREDELGS 2599
LQ+ +++ A ++I + ++E +D S + E ++Q L +LRE++ +
Sbjct: 825 SKLQEELDKYSQALRKNEILRQTIEE-----KDRSLGSMKEENNHLQEELERLREEQSRT 879
Query: 2600 DISA--LTL-RISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK 2656
A TL ++EL S+V +++T +E+++ +K + ++ + ++L + L+ +K+
Sbjct: 880 APVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKE 939
Query: 2657 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ 2716
E + + T T+LF +E E+++L+ K +L ++ +
Sbjct: 940 MDEFRYQHEQMNA----THTQLFLEKDE-----EIKSLQKTIEQIKTQLHEERQDIQTDN 990
Query: 2717 EELLVKETNMTSLQKDLSQVRDHLAEAK-EKL--SILEKEDETEVQESKKACMFEPLPIK 2773
++ +ET + SL + + L++A+ E+L I E+E E ++ K + + + +
Sbjct: 991 SDIF-QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQID-Q 1048
Query: 2774 LSKS-------IASQTDGTL-----KISSSNQTPQILVKNAGIQINLQSECSSEEVTEII 2821
LSK I Q D + +ISS++ T ++ +Q E+V ++
Sbjct: 1049 LSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMER---EKVFAVL 1105
Query: 2822 SQFTEK-------IEKMQELHAAEIL---------------------DMESRHISETETL 2853
++ T + KM ++ AA+ DM I +
Sbjct: 1106 NEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI 1165
Query: 2854 KREHYVAVQLLKEECGTLKAVIQCLRS-KEGSSIPELAHSDAYQTREICSSD--SGSDWG 2910
RE + + L ++C TL AV+Q + E + + Q R+ +W
Sbjct: 1166 IREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWK 1225
Query: 2911 QGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV--LSLTESPYSDG 2968
Q + T + E ++ + + + L+ + +N +QV L +S Y
Sbjct: 1226 QQVMTT-------VQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQS-YEQN 1277
Query: 2969 EDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLL 3028
E E L + + I + + KDL+ L + + S + E L
Sbjct: 1278 ETKLKNFGQE--LAQVQHSIGQLCNTKDLL----LGKLDIISPQLSSASLLTPQSAECLR 1331
Query: 3029 ALQQVFLEERSVLLAAFRTELT-ALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR 3087
A + L E S LL EL +L DA + L++ A E L++ +
Sbjct: 1332 ASKSEVLSESSELLQQELEELRKSLQEKDAT--IRTLQENNHRLSDSIAATSE-LERKEH 1388
Query: 3088 RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
SEI+ L + + + LK + K + L + + +++ E ++ ++
Sbjct: 1389 EQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENEL----LRQAV 1444
Query: 3148 TELQEQLSSEKMVVAELKSE---LAQTKLELETTLKA-QHKHLKELEAFRLEVKDKTDEV 3203
T L+E++ +M + +LK E + +T ET +A Q ++K F + +++K E
Sbjct: 1445 TNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMK----FSMMLREKEFEC 1500
Query: 3204 HLLND-TLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLN-- 3260
H + + LA EQ EKE+ K G EL L +++S +++ +
Sbjct: 1501 HSMKEKALAFEQLLK-------EKEQGKTG--------ELNQLLNAVKSMQEKTVVFQQE 1545
Query: 3261 ----LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
+L +QKQ+ N + Q E QR L D + Q LLESE RE +
Sbjct: 1546 RDQVMLALKQKQMENTALQN-EVQR-LRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
Query: 3317 DRERELHAQ-------LQSSDGTGQSRPPLPS------EDLLKELQKQLEEKHSRIVELL 3363
DRE +L + L SS ++ S ++ L + KQ +E ++
Sbjct: 1604 DREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQ 1663
Query: 3364 NETEKYKLDSLQTRQQME----KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQR-- 3417
+ ++Y L + +E +++ ++ L+ +++ E +K L+ KV LQ
Sbjct: 1664 EQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECL 1723
Query: 3418 ---------------QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESR--RIL 3460
QL+ K +Q+ +L + + Q ++ + QK+ + E + ++L
Sbjct: 1724 DEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVL 1783
Query: 3461 YQNL 3464
+NL
Sbjct: 1784 MRNL 1787
Score = 170 bits (430), Expect = 3e-41
Identities = 356/1701 (20%), Positives = 699/1701 (41%), Gaps = 260/1701 (15%)
Query: 1300 EETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK--TKLEEQVQELESLISSLQQQLKET 1357
E TE + + ++I+ H S + L+K T LEE+ + E I +
Sbjct: 40 EGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQ 99
Query: 1358 EQNYEAEIHCLQKR----------LQAVSESTVPPSLPVDSVVITESDAQR-TMYPGSCV 1406
Q E EI L+ R LQ+ ++S VP V + + S A + +P +
Sbjct: 100 LQQKEVEISHLKARQIALQDQLLKLQSAAQS-VPSGAGVPATTASSSFAYGISHHPSAFH 158
Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
++D S + + +N V LE + +A+ + + Q+E+ ++
Sbjct: 159 DDDMDFGDIISSQQEINRLSNEVSRLESEVGHW--RHIAQTSKAQGTDNSDQSEICKLQN 216
Query: 1467 G----KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG 1522
K+N + H ++ KL++ I + E + ++E + L L
Sbjct: 217 IIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTE--ISRRHREELS-DYEERIEELENLLQ 273
Query: 1523 EHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS-----VSSMDAS 1577
+ G ++ +D I E + + + E K + + D+I +SS +
Sbjct: 274 QGGSGVI--ETDLSKIYEMQKTIQVLQIEKVESTKKM---EQLEDKIKDINKKLSSAEND 328
Query: 1578 RQLMLNE-EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ-----EEIK 1631
R ++ E EQL +++++ + + + L+ + ++Q + E + L EE+
Sbjct: 329 RDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVF 388
Query: 1632 RLNRQLAQR-------SSIDNENLVSERERVLLEELEAL-KQLSLAGREKLCCELRNSST 1683
RL + L+ SS++ +N ++E L +E L K+ SL +EK EL+ S
Sbjct: 389 RLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKE--ELQMSLL 446
Query: 1684 QTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTA 1743
+ N E ++ ++ LD + D+ + + E+ Q + + + L+ ++
Sbjct: 447 KLNNEYE---VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEK--ETLIAEIEELD 501
Query: 1744 AVEETIGRHVLGILDRSSKSQSSA-SLIWRSEAEAS-VKSCVHE------EHTRVTDESI 1795
+ +H++ I D+ SK Q+ S+I + + + + K VH+ + T+ D
Sbjct: 502 RQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQK 561
Query: 1796 PSYSGSDMPRNDINMWSKVTEEGTE-LSQRLVRSGFAGTEIDPENEELMLNI---SSRLQ 1851
S++ ND+++ + E+ E L +L +S + I EN EL +I L
Sbjct: 562 EKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 621
Query: 1852 AAVEKLLEAISETSSQ--------------------LEHAKVTQTELMRESFRQKQEATE 1891
+L++++++ S+ L + L + +F K E +
Sbjct: 622 RIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEK 681
Query: 1892 SLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQE 1951
+ E++R +L E QL++E + T+ E EK +I E E
Sbjct: 682 LVLACEDVRHQLEECLAGNNQLSLE-------------KNTIVETLKMEKGEI----EAE 724
Query: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
L A RL E E + ++ E LS + + + L++ +K E E++
Sbjct: 725 LCWAKKRLLE---EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781
Query: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
E++ D ++ L +EEQ + +L +K + L++++ L+++L+K + L +
Sbjct: 782 IEQMDTDHKETKDVLSSSLEEQ-KQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840
Query: 2072 QAIDRE-------------HERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2118
I R+ E + Q+E+++L ++ R P+++ +T + +
Sbjct: 841 NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS---RTAPVADPKTLD------SV 891
Query: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGA 2178
E + S+L KE L+ +I+ + IE +L Q+L E +K
Sbjct: 892 TELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQ---------EQKKEMDE 942
Query: 2179 VEAKPEL--SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2236
+ E + QL E+D +EI +L++ +EQ + +L + +++Q + + +
Sbjct: 943 FRYQHEQMNATHTQLFLEKD------EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQE 996
Query: 2237 KKESTTRLQELEQENKLFKDDMEKLGLAIKESD-----------AMSTQDQHVL---FGK 2282
K + ++ +++ L K + E+L IKE + +++ Q + GK
Sbjct: 997 TKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGK 1056
Query: 2283 FAQIIQEKEVEIDQLN---------EQVTKLQQQLKITTDNK-----VIEEKNELIRDLE 2328
QIIQ+K++EI L+ + V LQQQL+ + V+ EK L+
Sbjct: 1057 LTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLK 1116
Query: 2329 TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQ----KTSMNAHSLSEEADSL 2384
T+ +M + +E + +L + +KL + GQ +T N + E D
Sbjct: 1117 TEYHKMMD----IVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIE 1172
Query: 2385 KHQLDVVIAEKLALEQQVETAN----------EEMTFMKNVLKETNFKMNQLTQELFSL- 2433
L LA+ Q T N EE+ ++ LK+ KM + Q++ +
Sbjct: 1173 IDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTV 1232
Query: 2434 -KRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF------ 2486
+ ES + + + + V +D S + +L+V T +N+T K+F
Sbjct: 1233 QNMQHESAQLQEELHQLQAQVLVD--SDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQ 1290
Query: 2487 EENGKGSIINLETRLL--------QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2538
++ G + N + LL QL S+ S + +C + K E +E+LQ+
Sbjct: 1291 VQHSIGQLCNTKDLLLGKLDIISPQL-SSASLLTPQSAECLRASK--SEVLSESSELLQQ 1347
Query: 2539 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQ----NLNQLRE 2594
++ L+K ++EK A + +QE D+ +SE ER + + QL+E
Sbjct: 1348 ELEELRKSLQEKDAT-------IRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKE 1400
Query: 2595 --DELGSDISALTLRISELESQVV---EMHTSLILEKEQVEIAEKNVLEKEKKL-LELQK 2648
D L + L I Q++ E T+ + E E + A N+ E+ L +++ K
Sbjct: 1401 KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGK 1460
Query: 2649 LLEGNEK-------KQRE---------------KEKKRSPQDVEVLKTTTELFHSNEESG 2686
L NEK K+ E +EK+ ++ E +E G
Sbjct: 1461 LKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQG 1520
Query: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
EL L + + + ++++ +++ L K+ T+LQ ++ ++RD + ++
Sbjct: 1521 KTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQE 1580
Query: 2747 LSILEKE-DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
L L E+E +++A E KL K + + +SSSN ++NA Q
Sbjct: 1581 LERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKL--VSSSN-----AMENASHQ 1633
Query: 2806 INLQSECSSEEVTEIISQFTE 2826
++Q E E++ + Q E
Sbjct: 1634 ASVQVESLQEQLNVVSKQRDE 1654
Score = 159 bits (401), Expect = 7e-38
Identities = 382/1896 (20%), Positives = 760/1896 (40%), Gaps = 289/1896 (15%)
Query: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
+ML + V + +S+ E+E + +L S E L KL DLE +H +
Sbjct: 36 DMLMEGTEEVEAELPDSRTKEIEAIHA-ILRSENERLKKLCTDLEEKHEAS--------E 86
Query: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTL- 719
I KQQ +N++ QK + K I Q+QL+ KL+ QS+ + T
Sbjct: 87 IQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLL----KLQSAAQSVPSGAGVPATTA 142
Query: 720 ------------------------------QINELQKEIEILRQE----------EKEKG 739
+IN L E+ L E K +G
Sbjct: 143 SSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQG 202
Query: 740 TLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD-EKKTLEDMLKIHTP-- 796
T + E+ L+ +KE + + ++ + E S+L++ ++ L ++ + H
Sbjct: 203 TDNSDQSEIC----KLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREEL 258
Query: 797 VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN 856
EER+ L+++ + V E ++ + E + + Q +Q+ E++E + +K
Sbjct: 259 SDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTI--QVLQI-EKVESTKKMEQLEDKI 315
Query: 857 FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE----ELHLQRINPTTVKM 912
++N + L ++D + + +QE K + + E +L ++ P+ VK
Sbjct: 316 KDINKK--------LSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK- 366
Query: 913 KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972
+S E + +A++ + EV + E+ + L L++ + +LK +
Sbjct: 367 QSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMR--- 423
Query: 973 ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE 1032
I L +E L QEKE++ + +L +N E ++S T+ S LD + E
Sbjct: 424 IEVLEKEKSLLSQEKEELQMSLLKL-----NNEYEVIKSTATRDIS-LDSELHDLRLNLE 477
Query: 1033 GSVSKVNKSFGEESKIMVE-DKVSFENMTVGEESKQEQLILDHLPSVTKE--SSLRATQP 1089
++N+S E+ ++ E +++ +N E +K LI D L E S + +
Sbjct: 478 AKEQELNQSISEKETLIAEIEELDRQNQ---EATKHMILIKDQLSKQQNEGDSIISKLKQ 534
Query: 1090 SENDKLQKELNVLKSEQNDL--RLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147
ND+ +K ++ L+ ++ D+ L ++ +++ S V + ++ +E++ + +L
Sbjct: 535 DLNDE-KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVE----NLV 589
Query: 1148 EELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLC 1207
++L +QE + +QK LEL+ Q + + + L+ L + + S F TL
Sbjct: 590 DQLNKSQESNV-SIQK-ENLELKEHIRQNEEELSRIRNELMQSLNQ---DSNSNFKDTL- 643
Query: 1208 SVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY 1267
L E + N + E ++EN L+ ++V+ E + V +
Sbjct: 644 --LKEREAEVRNLKQNLSELEQ----LNEN----LKKVAFDVKMENEKLVLACEDVRHQL 693
Query: 1268 NKLLVLQTRLSKIWGQQTDGMKLEFGE---------ENLPKEETEFLSIHSQMTNLEDID 1318
+ L +LS + +K+E GE + L +E ++ +++N +++
Sbjct: 694 EECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLN 753
Query: 1319 VN-------HKSKLSSLQDLEKTKLEEQVQELES--------LISSL--QQQLKETEQNY 1361
+ H KL+ +D+E +L++ ++++++ L SSL Q+QL +
Sbjct: 754 TSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKK 813
Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
E I L++R + E + + +++ I+ G
Sbjct: 814 EIFIEKLKERSSKLQEEL--------------DKYSQALRKNEILRQTIEEKDRSLG--S 857
Query: 1422 VKEETN-IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAV 1480
+KEE N + + LE+ +EQ ++ +E+S+++ KE+ + H
Sbjct: 858 MKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQK 917
Query: 1481 CQQEQHY--------FNEMKLSQDQIGFQ------TFETVDVKFKEEFKPLSK------- 1519
++Q+ E K D+ +Q T + ++ EE K L K
Sbjct: 918 IIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKT 977
Query: 1520 ELGEHGKEILLSNSDPHDIPESKDCVLTI----SEEMFSKDKTFIVRQSIHDEISVSSMD 1575
+L E ++I NSD E+K L I + SK +T + + I + +
Sbjct: 978 QLHEERQDIQTDNSD--IFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLL 1035
Query: 1576 ASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQRED-----QEQLQEEI 1630
+ + L ++ + + E+ + Q QQ ++ H R Q+QLQ
Sbjct: 1036 NEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYA 1095
Query: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNE 1690
+ A + EN + E + ++ A K+ +L KL E + ST+ ++ +
Sbjct: 1096 MEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALI---KLQDENKKLSTRFESSGQ 1152
Query: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
++ +T + + +D+ + LS + + LL V++T++ E G
Sbjct: 1153 ---DMFRETIQNLSRIIREKDIEIDALSQK-----------CQTLLAVLQTSSTGNEAGG 1198
Query: 1751 ------RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMP 1804
+L D+ K Q W+ + +V++ HE + E + +
Sbjct: 1199 VNSNQFEELLQERDK-LKQQVKKMEEWKQQVMTTVQNMQHE--SAQLQEELHQLQAQVLV 1255
Query: 1805 RNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISET 1864
+D N SK+ + T L Q +NE + N L + + +
Sbjct: 1256 DSDNN--SKLQVDYTGLIQSY-----------EQNETKLKNFGQELAQVQHSIGQLCNTK 1302
Query: 1865 SSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924
L + +L S Q A E L+ + E L E S +Q EL K+
Sbjct: 1303 DLLLGKLDIISPQLSSASLLTPQSA-ECLRASKS--EVLSESSELLQQELEELRKS---- 1355
Query: 1925 DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQ-----QQIQEERELLSRQ 1979
EK R +QE + + + A++ L+ E EQ +Q++E++++L +
Sbjct: 1356 ---LQEKDATIRTLQENNHRL----SDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKL 1408
Query: 1980 KEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDV---EEQVSR 2036
+ QLL E + E + + V +L++++ LE+D+ + + +
Sbjct: 1409 LKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAV-TNLKERILILEMDIGKLKGENEK 1467
Query: 2037 FIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKV 2096
+E + K TE L++ N L ++E E +++ EQ LK
Sbjct: 1468 IVETYRGKETEYQALQETNMKFSMMLR-----------EKEFECHSMKEKALAFEQLLK- 1515
Query: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVREL 2156
+ +T E+ QL N +K +K ++Q+ ++++ E L+ V+ L
Sbjct: 1516 -----EKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRL 1570
Query: 2157 EQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFR 2216
S +++ R H +E++ + E +R+A + K++T LEE+L
Sbjct: 1571 RDKEFRSNQELERL--RNHL--LESEDSYTREALAAEDREA--KLRKKVTVLEEKLVSSS 1624
Query: 2217 EELENKNE----EVQQLHMQLEI---QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD 2269
+EN + +V+ L QL + Q+ E+ +L +++ K + + L + ++
Sbjct: 1625 NAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ 1684
Query: 2270 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLET 2329
K Q+I E + + L +V LQ+ L N ++ + L L+
Sbjct: 1685 QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECL--DEANAALDSASRLTEQLDV 1742
Query: 2330 QIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN 2365
+ E + E +KR E E L++V +KL LAN
Sbjct: 1743 KEEQI----EELKRQNELRQEMLDDVQKKL-MSLAN 1773
Score = 155 bits (391), Expect = 1e-36
Identities = 363/1875 (19%), Positives = 769/1875 (41%), Gaps = 312/1875 (16%)
Query: 701 KLKDLQQSLVNSKSEEMTLQINELQ-KEIE----ILRQEEKEKGTLEQEVQELQLKTELL 755
++ + + ++ +EE+ ++ + + KEIE ILR E + L++ +L+ K E
Sbjct: 29 QISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENER---LKKLCTDLEEKHEAS 85
Query: 756 EKQMKEKENDLQEKFAQLEAENSILKDEKKTLED-MLKIHTPVSQEERLIFLDSIKSKSK 814
E Q+K++ + + Q E E S LK + L+D +LK+ + + + + S
Sbjct: 86 EIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSS 145
Query: 815 --------------DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
D + +I +E L + +L E+ R+ ++ N
Sbjct: 146 FAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDN 205
Query: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
Q E L + +L+ +++++ +++ ++ L + H Q++ + + + + D +
Sbjct: 206 SD--QSEICKLQNIIKELKQNRSQEIDDHQHEMSVL-QNAHQQKLTEISRRHREELSDYE 262
Query: 921 KTF--VAETLEMGE--VVEKDTTEL-----------MEKLEVTKREKLELSQRLSDLSEQ 965
+ + L+ G V+E D +++ +EK+E TK+ + +L ++ D++++
Sbjct: 263 ERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKME-QLEDKIKDINKK 321
Query: 966 LKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025
L + L E + L EK Q+ C L++ + + V+ DT + ++
Sbjct: 322 LSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEK--ERILA 379
Query: 1026 MTSRGAEGSVSKVNKSFGE-ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084
++ E V ++ ++ + E++IM ++ +N + K + I + KE SL
Sbjct: 380 QSASVEE--VFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRI----EVLEKEKSL 433
Query: 1085 RATQPSEND----KLQKELNVLKS----------EQNDLRLQMEAQRICLSLVYSTHVDQ 1130
+ + E KL E V+KS E +DLRL +EA+ L+ S
Sbjct: 434 LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETL 493
Query: 1131 VREYME-----NEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1185
+ E E E K + +K++L Q E + K+ Q + DE K +H
Sbjct: 494 IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---------DLNDEKKRVH 544
Query: 1186 LLIGK---LQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYISENEDPE 1241
L + K + + +Q+ ++ + T + EDK EN D ++++++
Sbjct: 545 QLEDDKMDITKELDVQKEKLIQSEVALNDLHLT-----KQKLEDKVENLVDQLNKSQESN 599
Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
+ + EN+ L + + +L ++ L + Q ++ F + L + E
Sbjct: 600 VSIQK-------ENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNS---NFKDTLLKERE 648
Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKL----EEQVQELESLIS--------- 1348
E ++ ++ LE ++ N K K++ +E KL E+ +LE ++
Sbjct: 649 AEVRNLKQNLSELEQLNENLK-KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEK 707
Query: 1349 -SLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK 1407
++ + LK + EAE+ +KRL + I E R + +
Sbjct: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKY--------EKTIEELSNARNLNTSALQL 759
Query: 1408 KNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG 1467
++ E + K++ I +L + Q + + K ++S S+ +Q +L+++
Sbjct: 760 EH-----EHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLE--EQKQLTQLINK 812
Query: 1468 KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKF---KEEFKPLSKELGEH 1524
KE + + QE+ L +++I QT E D KEE L +EL
Sbjct: 813 KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERL 872
Query: 1525 GKEILLSNSDPHDIPESKDCVLTISEEMFSKD--KTFIVRQSIHDEISVSSMDASRQLML 1582
+E S + P P++ D V ++ E+ + K + + H + + + S+ +L
Sbjct: 873 REE--QSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL 930
Query: 1583 NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSS 1642
+ L++ ++E+ +H+Q + H + + E+ + LQ+ I+++ QL +
Sbjct: 931 --QSLQEQKKEMDEFRYQHEQ----MNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE--- 981
Query: 1643 IDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT--- 1699
ER+ + + + + E + S +NG+E + +T
Sbjct: 982 --------ERQDIQTDNSDIFQ------------ETKVQSLNIENGSEKHDLSKAETERL 1021
Query: 1700 ---FKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGI 1756
KE+EL+ K +L+ + +L K ++L K EV K T +++ + +
Sbjct: 1022 VKGIKERELEIK-------LLNEKNISLTKQIDQLSKD--EVGKLTQIIQQK-DLEIQAL 1071
Query: 1757 LDRSSKSQSSASLIWRSEA------EASVKSCVHEEHTRVTDESIPSYSGS-DMPRNDIN 1809
R S + + +++ + E V E TR Y D+
Sbjct: 1072 HARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEA 1131
Query: 1810 MWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL------LEAISE 1863
K+ +E +LS R SG ++ E + + I ++ L L A+ +
Sbjct: 1132 ALIKLQDENKKLSTRFESSG---QDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQ 1188
Query: 1864 TSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL--------HEESRAREQL-- 1913
TSS A + E +++ + + +K EE ++++ HE ++ +E+L
Sbjct: 1189 TSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQ 1248
Query: 1914 --------AVELSKAE----GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQE 1961
+ SK + G+I Y +T + QE + + Q L +
Sbjct: 1249 LQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGK 1308
Query: 1962 LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK 2021
L+ Q+ L + E ++A + ++L E+ +L++++LE ++ + +D +
Sbjct: 1309 LDIISPQLSSASLLTPQSAECLRAS----KSEVLSESSELLQQELEELRKSLQEKDATIR 1364
Query: 2022 QVKALEIDVEEQVSRFIELEQEKN----TELMDLRQQNQALEKQLEKMRKFL-------- 2069
++ + + ++ ELE++++ +E+ L+++ L+K L++ +
Sbjct: 1365 TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLL 1424
Query: 2070 --DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
+E ++ +E ++ +Q + L++++ ++ E LK + +K E
Sbjct: 1425 SSNENFTNKVNENELLRQAVTNLKERILIL--------------EMDIGKLKGENEKIVE 1470
Query: 2128 LLLSKEQLQRDIQERNEEIEKL----EFRVRELEQALLVSADTFQKVEDRKH------FG 2177
KE + +QE N + + EF +++ L ++ E K
Sbjct: 1471 TYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLN 1530
Query: 2178 AVEAKPELSLEVQLQAERD----AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2233
AV++ E + V Q ERD A+ +K+ E T L+ ++++ R++ N+E+++L L
Sbjct: 1531 AVKSMQEKT--VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHL 1588
Query: 2234 EIQKKESTTR--LQELEQENKLFKDDMEKLGLAIKESDAM------------STQDQHVL 2279
++ ++S TR L ++E KL K + S+AM S Q+Q +
Sbjct: 1589 -LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNV 1647
Query: 2280 FGK----FAQIIQEKEVEIDQLNEQVTKLQ------QQLKITTDNKVIEEKNELIRDLET 2329
K A + + ++ Q + LQ QQ + + +E++ +LI + +
Sbjct: 1648 VSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKK 1707
Query: 2330 QIECL----MSDQECVKRN----------------REEEIEQLNEVIEKLQQELANIGQK 2369
E L +S QEC+ +EE+IE+L E Q+ L ++ +K
Sbjct: 1708 NAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKK 1767
Query: 2370 TSMNAHSLSEEADSL 2384
A+S + D +
Sbjct: 1768 LMSLANSSEGKVDKV 1782
Score = 154 bits (389), Expect = 2e-36
Identities = 326/1661 (19%), Positives = 671/1661 (40%), Gaps = 278/1661 (16%)
Query: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF 1304
+R E+ D++E + L N + + + V++T LSKI+ Q L+ + K+
Sbjct: 254 HREELSDYEERIEELENLLQQGGSG--VIETDLSKIYEMQKTIQVLQIEKVESTKK---- 307
Query: 1305 LSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAE 1364
M LED + KLSS ++ EQ Q ++ ++Q+ E +N + E
Sbjct: 308 ------MEQLEDKIKDINKKLSSAENDRDILRREQEQ-----LNVEKRQIMEECENLKLE 356
Query: 1365 IHCLQKRLQAVSES-TVPPSLPVDSVVITE--------SDAQRTMYPGSCVKKN---IDG 1412
LQ S++ T + S + E SDA+ + S + ++ +
Sbjct: 357 CSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAED 416
Query: 1413 TIEFSGEFGVKEETNIVKLLEKQYQEQL---------EEEVAKVIVSMSIAF-------- 1455
++ V E+ K L Q +E+L E EV K + I+
Sbjct: 417 NLKLKMRIEVLEKE---KSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473
Query: 1456 ----AQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFK 1511
A++ EL++ KE + + + +Q Q M L +DQ+ Q E + K
Sbjct: 474 LNLEAKEQELNQSISEKETLIA--EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISK 531
Query: 1512 EEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISV 1571
L ++L + K + D DI + D + E +
Sbjct: 532 -----LKQDLNDEKKRVHQLEDDKMDITKELD---------------------VQKEKLI 565
Query: 1572 SSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIK 1631
S A L L +++LED + LV Q + Q++ +++ ++ E R+++E+L
Sbjct: 566 QSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRN 625
Query: 1632 RLNRQLAQRSSID-NENLVSERE---RVLLEELEALKQLS----------LAGREKL--- 1674
L + L Q S+ + + L+ ERE R L + L L+QL+ EKL
Sbjct: 626 ELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLA 685
Query: 1675 CCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKI 1734
C ++R+ + GN NQ +E+ T E L + ++ E+ ++ L++AN
Sbjct: 686 CEDVRHQLEECLAGN-NQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEAN------ 737
Query: 1735 LLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDES 1794
K +EE L S HE ++ +
Sbjct: 738 -----KYEKTIEELSNARNLN---------------------TSALQLEHEHLIKLNQKK 771
Query: 1795 IPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV 1854
+++ +N M + E LS L E ++ + + ++ + +
Sbjct: 772 --DMEIAELKKNIEQMDTDHKETKDVLSSSL------------EEQKQLTQLINKKEIFI 817
Query: 1855 EKLLEAISETSSQLEHAK--VTQTELMRESFRQKQEATESLK-----CQEELRERLHEES 1907
EKL E S+ +L+ + + E++R++ +K + S+K QEEL E+S
Sbjct: 818 EKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS 877
Query: 1908 RARE-----------QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
R +LA E+S+ + K E +I+ II+ Q +
Sbjct: 878 RTAPVADPKTLDSVTELASEVSQLNTI-------KEHLEEEIKHHQKIIEDQNQSKMQLL 930
Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016
LQE + E + + + E ++ + E + L + E++ + E + +
Sbjct: 931 QSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDN 990
Query: 2017 DDLQKQVKALEIDVEE----------QVSRFIELEQEKNTELMDLRQQNQALEKQLEKM- 2065
D+ ++ K +++E + R ++ +E+ E+ L ++N +L KQ++++
Sbjct: 991 SDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLS 1050
Query: 2066 ------------RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP----RFQPISEHQTR 2109
+K L+ QA+ Q++ L+QQL+ + + +TR
Sbjct: 1051 KDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTR 1110
Query: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQK 2169
E +HLK + K +++ +KE +Q+ N+ KL R Q D F+
Sbjct: 1111 E----NSHLKTEYHKMMDIVAAKEAALIKLQDENK---KLSTRFESSGQ------DMFR- 1156
Query: 2170 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEE---QLEQFREELENKNEEV 2226
E ++ + + ++ ++ Q + + + T E QF E L+ +++
Sbjct: 1157 -ETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLK 1215
Query: 2227 QQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI 2286
QQ+ ++E K++ T +Q ++ E+ ++++ +L + D+ + V + Q
Sbjct: 1216 QQVK-KMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLV-DSDNNSKLQVDYTGLIQS 1273
Query: 2287 IQEKEVEIDQLNEQVTKLQQQL-KITTDNKVIEEKNELIRDLETQIECLMSDQ-ECVKRN 2344
++ E ++ +++ ++Q + ++ ++ K ++I + L EC++ +
Sbjct: 1274 YEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRAS 1333
Query: 2345 REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEE----ADSLKHQLDVVIAEKLALEQ 2400
+ E + + +E++++ +EL Q+ +L E +DS+ ++ E +
Sbjct: 1334 KSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDS 1393
Query: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKR-------ERESVEK-IQSIPENSVN 2452
+++ E+ ++ +LKE + + + +L S E E + + + ++ E +
Sbjct: 1394 EIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILI 1453
Query: 2453 VAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSII---------NLETRLLQ 2503
+ +D + K K E E ++ K E Q E N K S++ +++ + L
Sbjct: 1454 LEMD-IGKLKGENEKIVETYRGKETEYQALQ---ETNMKFSMMLREKEFECHSMKEKALA 1509
Query: 2504 LESTVSAKDL----ELTQCYKQIKDMQEQ--------GQFETEMLQKKIVN--LQKIVEE 2549
E + K+ EL Q +K MQE+ Q + QK++ N LQ V+
Sbjct: 1510 FEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQR 1569
Query: 2550 KVAAALVSQIQLEAVQEYAKFCQDNQT---ISSEPERTNIQNLNQLREDELGSDISALTL 2606
S +LE ++ + +D+ T +++E ++ + E++L S +A+
Sbjct: 1570 LRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMEN 1629
Query: 2607 RISELESQVVEMHTSL-ILEKE------QVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659
+ QV + L ++ K+ Q+ ++++ V + L LQ +LE + +
Sbjct: 1630 ASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ----Q 1685
Query: 2660 KEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEEL 2719
+EK ++E K + N E+ E + + + +A A + A +L E+L
Sbjct: 1686 EEKAMYSAELEKQKQLIAEWKKNAEN---LEGKVISLQECLDEANAAL--DSASRLTEQL 1740
Query: 2720 LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760
VKE + L++ ++ L + ++KL L E +V +
Sbjct: 1741 DVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDK 1781
Score = 142 bits (359), Expect = 5e-33
Identities = 336/1805 (18%), Positives = 725/1805 (40%), Gaps = 261/1805 (14%)
Query: 374 KNMKLELTNSKQKE--------RQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425
+ ++ EL +S+ KE R +E +K+L +EE H+ S+ + +++
Sbjct: 43 EEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEE----KHEASEIQ---IKQQSTS 95
Query: 426 TQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMK----------------TRHKG 469
+ +L+Q E+ + +QI Q L Q AQ + H
Sbjct: 96 YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155
Query: 470 EMENALRSYSNITVNEDQIKLMNVAINELNI------------KLQDT-NSQKEKLKEEL 516
+ + +I ++ +I ++ ++ L K Q T NS + ++ +
Sbjct: 156 AFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQ 215
Query: 517 GLILEEKCALQRQLEDLVEELSFSREQIQ--------RARQTIAEQESKLNEAHKSLSTV 568
+I E K ++++D E+S + Q R R+ +++ E ++ E L
Sbjct: 216 NIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQG 275
Query: 569 ED--LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ-EAELERL 625
++ ++ E +K +++ +V + K K+E LE + + +++ ++ + ++ R
Sbjct: 276 GSGVIETDLSKIYEMQKTIQVLQIEKVESTK-KMEQLEDKIKDINKKLSSAENDRDILRR 334
Query: 626 RTQLLFSHEEELSKLKEDLEIE-HRINIEKLKDNLGIHYKQQI--------------DGL 670
+ L + ++ + E+L++E ++ +K + + K++I L
Sbjct: 335 EQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQAL 394
Query: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
+ ++ + +DN + + N + ++ + ++SL++ + EE+ + + +L E E+
Sbjct: 395 SDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEV 454
Query: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDM 790
++ +L+ E+ +L+L E E+++ + ++ + A++E + + ++ + M
Sbjct: 455 IKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIE---ELDRQNQEATKHM 511
Query: 791 LKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTF 850
+ I +S+++ DSI SK K + +++ + L+ + + +E++ Q+
Sbjct: 512 ILIKDQLSKQQN--EGDSIISKLKQDLNDEKKRV-----HQLEDDKMDITKELDVQKEKL 564
Query: 851 SFAE---KNFEVNYQELQEEYACLLKVKDDLEDSK---NKQELEYKSKLKALNEELH--- 901
+E + + Q+L+++ L+ + ++S K+ LE K ++ EEL
Sbjct: 565 IQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIR 624
Query: 902 ---LQRIN--------PTTVKMKSSVFDEDKTFVAETLEMGEVVEK---DTTELMEKLEV 947
+Q +N T +K + + K ++E ++ E ++K D EKL +
Sbjct: 625 NELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL 684
Query: 948 T---KREKLE--------LSQRLSDLSEQLKQKHGEISF--------LNEEVKSLKQEKE 988
R +LE LS + + E LK + GEI L EE ++ E
Sbjct: 685 ACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIE 744
Query: 989 QVS----LRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGE 1044
++S L L++ H N Q D +++ L + M + E + ++ S E
Sbjct: 745 ELSNARNLNTSALQLEHEHLIKLN-QKKDMEIAELKKNIEQMDTDHKE-TKDVLSSSLEE 802
Query: 1045 ESKI--MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT----------QPSEN 1092
+ ++ ++ K F SK ++ + + ++ K LR T EN
Sbjct: 803 QKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN 862
Query: 1093 DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQ---VREYMENE---KDKAL--- 1143
+ LQ+EL L+ EQ+ + + + ++ V Q ++E++E E K +
Sbjct: 863 NHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQ 922
Query: 1144 CSLKEELIFAQEEKIKELQKIHQLELQTMKTQ-----ETGDEGKPLHLLIGKLQKAVSEE 1198
K +L+ + +E+ KE+ + Q T E +E K L I +++ + EE
Sbjct: 923 NQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEE 982
Query: 1199 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258
+ E +L E N +K + +E +++ E++ E +
Sbjct: 983 RQDIQTDNSDIFQETKVQSLNIE-NGSEKHDLSKAETERLVKGIKERELEIKLLNEKNIS 1041
Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318
L ++ + + T++ + + + + ++ +L Q +E
Sbjct: 1042 LTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTS-HTQDVVYLQQQLQAYAMEREK 1100
Query: 1319 V----NHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQA 1374
V N K++ +S E K+ + V E+ + LQ + K+ L R ++
Sbjct: 1101 VFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKK-----------LSTRFES 1149
Query: 1375 VSESTVPPSLPVDSVVITESDAQRTMYPGSC-VKKNIDGTIEFSGEFGVKEETNIVKLLE 1433
+ ++ S +I E D + C + T E G +LL
Sbjct: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELL- 1208
Query: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKL 1493
Q +++L+++V K+ + S + QA + + N KL
Sbjct: 1209 -QERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSD----NNSKL 1263
Query: 1494 SQDQIG-FQTFETVDVKFK---EEFKPLSKELGE--HGKEILLSNSDPHD---------I 1538
D G Q++E + K K +E + +G+ + K++LL D
Sbjct: 1264 QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLT 1323
Query: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDAS-RQLMLNEEQLED---MRQEL 1594
P+S +C+ E+ S+ + ++ S+ DA+ R L N +L D EL
Sbjct: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383
Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSE--- 1651
R +EH+Q + ++Q++ +++ ++L +E L + + + NEN ++
Sbjct: 1384 ER--KEHEQT-----DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNE 1436
Query: 1652 -----------RERVLLEELEALKQLSLAG-REKLCCELRNSSTQTQNGNE--------- 1690
+ER+L+ E++ K L G EK+ R T+ Q E
Sbjct: 1437 NELLRQAVTNLKERILILEMDIGK---LKGENEKIVETYRGKETEYQALQETNMKFSMML 1493
Query: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
+ E E + KEK L + ++L + N+LL + + + T ++
Sbjct: 1494 REKEFECHSMKEKALAFE------QLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERD 1547
Query: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810
+ +L + + ++ + + + R + + E ES SY+ + D
Sbjct: 1548 QVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE- 1606
Query: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870
+K+ ++ T L ++LV S A M N S + VE L E ++ S Q +
Sbjct: 1607 -AKLRKKVTVLEEKLVSSSNA-----------MENASHQASVQVESLQEQLNVVSKQRDE 1654
Query: 1871 AKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930
+ Q + +E +Q + +L+ E H + + + EL K + +I +
Sbjct: 1655 TAL-QLSVSQEQVKQYALSLANLQMVLE-----HFQQEEKAMYSAELEKQKQLIAEWKKN 1708
Query: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
E ++ + +D L AS ++L+ +++QI+E L RQ E + V
Sbjct: 1709 AENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEE----LKRQNELRQEMLDDV 1764
Query: 1991 EQQLL 1995
+++L+
Sbjct: 1765 QKKLM 1769
Score = 124 bits (312), Expect = 1e-27
Identities = 325/1630 (19%), Positives = 688/1630 (42%), Gaps = 247/1630 (15%)
Query: 2184 ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT- 2242
++ +E + E + D + KEI + L E L+ ++++ H EIQ K+ +T
Sbjct: 36 DMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTS 95
Query: 2243 ---RLQELEQENKLFK-------DDMEKLGLAIKESDA-----MSTQDQHVLFG------ 2281
+LQ+ E E K D + KL A + + +T +G
Sbjct: 96 YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155
Query: 2282 -------KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2334
F II ++ EI++L+ +V++L+ ++ + +++I L
Sbjct: 156 AFHDDDMDFGDIISSQQ-EINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
Query: 2335 MSDQECVKRNREEEIEQLNEVIEKL----QQELANIGQKTSMNAHSLSEEADSLKHQLD- 2389
+ + +K+NR +EI+ + L QQ+L I ++ E + L++ L
Sbjct: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
Query: 2390 ------------VVIAEKLALEQQVE--TANEEMTFMKNVLKETNFKMNQLTQELFSLKR 2435
+ +K Q+E + ++M +++ +K+ N K++ + L+R
Sbjct: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
Query: 2436 ERE--SVEKIQSIPENSVNVAIDHLSKDKP----------ELEVVLTEDALKSLENQTYF 2483
E+E +VEK Q I E N+ ++ SK +P E E +L + A S+E
Sbjct: 335 EQEQLNVEKRQ-IMEECENLKLE-CSKLQPSAVKQSDTMTEKERILAQSA--SVEEVFRL 390
Query: 2484 KSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2543
+ + + I+ L + L +++++ +L+L + E+L+K+ L
Sbjct: 391 QQALSDAENEIMRLSS--LNQDNSLAEDNLKL--------------KMRIEVLEKEKSLL 434
Query: 2544 QKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDIS- 2602
+ EE + L + E ++ A + IS + E +++ + +E EL IS
Sbjct: 435 SQEKEELQMSLLKLNNEYEVIKSTA-----TRDISLDSELHDLRLNLEAKEQELNQSISE 489
Query: 2603 --ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2660
L I EL+ Q E +IL K+Q+ K E + + +L++ L N++K+R
Sbjct: 490 KETLIAEIEELDRQNQEATKHMILIKDQL---SKQQNEGDSIISKLKQDL--NDEKKRVH 544
Query: 2661 EKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL 2720
+ + D+ T EL E+ + E + TK +L ++K E L ++L
Sbjct: 545 QLEDDKMDI-----TKELDVQKEK---LIQSEVALNDLHLTKQKL---EDKVENLVDQLN 593
Query: 2721 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIAS 2780
+ + S+QK+ ++++H+ + +E+LS + E + + + + L + + +
Sbjct: 594 KSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653
Query: 2781 QTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEIL 2840
++ N+ +K + +++E ++ Q E + + L
Sbjct: 654 LKQNLSELEQLNEN----LKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ------L 703
Query: 2841 DMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI 2900
+E I ETLK E ++ E C K +++ +K +I EL+++ R +
Sbjct: 704 SLEKNTI--VETLKME---KGEIEAELCWAKKRLLE-EANKYEKTIEELSNA-----RNL 752
Query: 2901 CSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSL 2960
+S + I L + +IA + E D+ K+ K +L + E Q+ L
Sbjct: 753 NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ---MDTDHKETKDVLSSSLEEQKQLTQL 809
Query: 2961 TESPYSDGEDHSIQQVSEPWLEERKAYI-NTISSLKDLITKMQLQREAEVYDSSQSHESF 3019
+++ L+ER + + + + K ++ R+ + + +S S
Sbjct: 810 INK----------KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQT-IEEKDRSLGSM 858
Query: 3020 SDWRGELLLALQQVFLEE-RSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAA 3078
+ L L+++ E+ R+ +A +T + V LN +++ ++E+ +Q
Sbjct: 859 KEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKI 918
Query: 3079 MECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3138
+E Q + LL +Q +M+ + + EQ + +Q LE
Sbjct: 919 IED-QNQSKMQLLQSLQEQKKEMD--EFRYQHEQMNATHTQ------------LFLEKDE 963
Query: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQ-TKLELETTLKAQHKH-LKELEAFRL-- 3194
E+ S++ +++ QL E+ + S++ Q TK++ KH L + E RL
Sbjct: 964 EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
Query: 3195 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3254
+K++ E+ LLN+ S K+ +L + E KL + ++ E++ L + S
Sbjct: 1024 GIKERELEIKLLNEKNISLTKQIDQLS---KDEVGKLTQIIQQKDLEIQALHARISSTS- 1079
Query: 3255 RNLQLNLLLEQQKQLLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3311
+ Q + L+QQ Q ++K + +++ ++ L E + +++ E+ ++++
Sbjct: 1080 -HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ- 1137
Query: 3312 MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3371
D ++L + +SS +D+ +E + L SRI+ + ++
Sbjct: 1138 -----DENKKLSTRFESS-----------GQDMFRETIQNL----SRII----REKDIEI 1173
Query: 3372 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431
D+L + Q LQT N G ++ E+L ++ ++ +QQV K++
Sbjct: 1174 DALSQK------CQTLLAVLQTSSTGNEAGGVNSNQF----EELLQERDKLKQQVKKMEE 1223
Query: 3432 EGQRLQGIMQEFQKQ--ELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE 3489
Q++ +Q Q + +L+ E + ++L + N L D T ++Q + E
Sbjct: 1224 WKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNS---KLQVDYT--GLIQSYEQNE 1278
Query: 3490 TKESNYAKLIE--MNGGGTGCNHELEMIRQKLQCVASKL---QVLPQKASERLQFETAD- 3543
TK N+ + + + G CN + +++ KL ++ +L +L +++E L+ ++
Sbjct: 1279 TKLKNFGQELAQVQHSIGQLCNTK-DLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV 1337
Query: 3544 -DEDFIWVQENIDEIILQLQKLTG---QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHI 3599
E +Q+ ++E+ LQ+ E +S S + S ER +++ + I
Sbjct: 1338 LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELER--KEHEQTDSEI 1395
Query: 3600 SQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREK 3659
QL E+++ L+ ++ + + I+ S L+ N + +E E+ +
Sbjct: 1396 KQLKEKQDVLQKLLKEKDLLIK----------AKSDQLLSSNENFTNKV-NENELLRQAV 1444
Query: 3660 LTLQKSLKRAEAEVYKLKAELRNDSLLQTL-SPDSEHVTLKRIYGKY---LRAESF---- 3711
L++ + E ++ KLK E N+ +++T ++E+ L+ K+ LR + F
Sbjct: 1445 TNLKERILILEMDIGKLKGE--NEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS 1502
Query: 3712 --RKALIYQK 3719
KAL +++
Sbjct: 1503 MKEKALAFEQ 1512
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 171 bits (434), Expect = 1e-41
Identities = 420/2043 (20%), Positives = 793/2043 (38%), Gaps = 308/2043 (15%)
Query: 1592 QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE----- 1646
+E+V + ++ LL M + +E+ + LQ+E+ R+ LAQ + +E
Sbjct: 52 REIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKY 111
Query: 1647 NLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQG-EVEEQTFKEKEL 1705
N VSER LE+ L+ L TQ G Q E+ Q +E+
Sbjct: 112 NAVSER----LEQALRLEPGEL-------------ETQEPRGLVRQSVELRRQLQEEQAS 154
Query: 1706 DRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS 1765
R+ E + +Q+ ++L+ + + E G L + SQ
Sbjct: 155 YRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQD 214
Query: 1766 SASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRL 1825
S + R E E + + + + + ++ + S + DI KVT + T + L
Sbjct: 215 LESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIR---KVTNDWTRCRKEL 271
Query: 1826 VRSGFAGTEIDPENEELMLNISSRLQAAVEKLL---EAISETSSQLEHAKVTQTELMRES 1882
A + N SRL +++ +SE E + + +
Sbjct: 272 EHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELART 331
Query: 1883 FRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ--- 1939
R QEA L L E E+ +Q ++ E + D EK L ++Q+Q
Sbjct: 332 SRAVQEAGLGLSTGLRLAES-RAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDL 390
Query: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQIQEE--------RELLSRQKEAMKAEAGPVE 1991
+K D+ R+ EL A RL++ E+ Q+ ++ L +++ A++ E G
Sbjct: 391 DKADLSARVT-ELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGL 449
Query: 1992 QQLLQETEKLMKEKLEVQCQ---AEKVRDDLQKQVKALE--------------------- 2027
QQ L++ + + E Q +E+ D ++ L
Sbjct: 450 QQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRR 509
Query: 2028 -----IDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDV 2082
++ ++ ++ D+R + +A + L +RK Q D E ER
Sbjct: 510 GPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRK----QLSDSESERRA 565
Query: 2083 FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQER 2142
++++Q+L + + E REV++L + + + + S L S + Q+ +E
Sbjct: 566 LEEQLQRLRDKTDGAMQAH---EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEEL 622
Query: 2143 NEEIEKLEFRVRELE-QALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK 2201
+E EKL+ EL Q + + V+D + LE QL+ +R + ++
Sbjct: 623 RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLE-QLEGKRSVLAKE 681
Query: 2202 EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKL 2261
E+ + R+ L+ + EV + + E + E + +L E +D + KL
Sbjct: 682 LVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKL 741
Query: 2262 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321
A+ ES A D LN V +L EE+
Sbjct: 742 S-ALNESLAQDKLD---------------------LNRLVAQL-------------EEEK 766
Query: 2322 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
++ + Q E + V R +E +E+L +L+QE+A G + S+ ++EA
Sbjct: 767 SALQGRQRQAE----QEATVAREEQERLEEL-----RLEQEVARQGLEGSLRVAEQAQEA 817
Query: 2382 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE-SV 2440
LEQQ+ T E + ++ L + + +++ QEL +RE + V
Sbjct: 818 ----------------LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861
Query: 2441 EKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL-ENQTYFKSFEENGKGSIINLET 2499
E ++ +A +H +++V E ++L E T + +E +GS+ ++
Sbjct: 862 EALERAAREKEALAKEHAGL---AVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQR 918
Query: 2500 RLLQLEST-----------VSAKDL---ELTQCYKQIKDMQEQGQFETEMLQKKIV---- 2541
+L QLE+ + AK+ EL +QI QE+ + E++ +K+V
Sbjct: 919 QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER 978
Query: 2542 ---------------NLQKIVEEKVAA---------ALVSQIQLEAVQEYAKFCQDNQTI 2577
+LQ++ EK AA L SQ+Q E + A+ + + +
Sbjct: 979 EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEEL 1038
Query: 2578 SSEPERTNIQNLNQLREDEL----GSDISALTLRISE---LESQVVEMHTSLI---LEKE 2627
S E I L Q R++ L AL+L+ SE L +++ SL LE E
Sbjct: 1039 SEE-----IAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEME 1093
Query: 2628 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGF 2687
+ + ++ E+++ + + + QRE+ Q+V L+ +S
Sbjct: 1094 RQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDS-C 1152
Query: 2688 FNELEALRAE-------SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ---VR 2737
E E LR + + EL + K + QE V+ L++ L + R
Sbjct: 1153 LREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKER 1212
Query: 2738 DHLAEAKEKLSILEKEDETE--------VQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2789
+ L + E+L K+ E+E + +K + E + K G ++
Sbjct: 1213 EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVE 1272
Query: 2790 SSNQTPQILVKNAGIQIN-LQSECS--SEEVTEIISQFT--EKIEKMQELHAAEILDMES 2844
S + ++ Q+ L SE + E+ E+ + E+ EK +
Sbjct: 1273 RSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLL 1332
Query: 2845 RHISETETLKREHYVAVQLLKEECGTLKA----VIQCLRSKEGSSIPELAHSDAYQTREI 2900
+ + E +++E VA + L+E+ G + ++ L G+ +L H+ + +
Sbjct: 1333 KGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLE 1392
Query: 2901 CSSDSGSDWGQGIYLTHSQGFDIASEGR--GEESESATDSFPKKIK----GLLRAVHNEG 2954
+ ++ G + A+EGR G E+E A ++ G LR+ G
Sbjct: 1393 AARAEAAELGLRLS---------AAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
Query: 2955 MQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQ 3014
L L +P + E +N+ S+L + Q +
Sbjct: 1444 ---LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTL-ECSPGSQPPSPGPATSPAS 1499
Query: 3015 SHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVE 3074
RG L LQ++ +R RT+ +AL A + + +
Sbjct: 1500 PDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNRQLAE--MEAERDSATSRARQ 1555
Query: 3075 YQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE---LLEYNIQQKQS 3131
Q A+ ++A RRS+ + + A++ ++ +++R + + + + LE ++Q +S
Sbjct: 1556 LQKAVAESEEA-RRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATES 1614
Query: 3132 QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE---LETTLKAQHKHLKE 3188
++ Q ++S MK T+L+ K V+ +S + +L+ LE L+ L +
Sbjct: 1615 ELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1674
Query: 3189 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE-----RDK---- 3239
EA ++D+ D L +A + K+ LQ +E+ L + EE RDK
Sbjct: 1675 REAQAQALQDRVDS---LQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGL 1731
Query: 3240 -EELEDLKFSLESQKQRNLQLNLLL---EQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
E L SL S + +NL L L E +Q+L Q+++++ R +
Sbjct: 1732 TEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL---QERLDAARQALSEARKQSSSLG 1788
Query: 3296 LELQVL------LESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQ 3349
++Q L LE ++V E L + RE+ Q Q + L + L++ +
Sbjct: 1789 EQVQTLRGEVADLELQRV---EAEGQLQQLREVLRQRQEGEAAA-----LNTVQKLQDER 1840
Query: 3350 KQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ 3409
+ L+E+ + L + E K + ++ ++EKDR R+TL + + L
Sbjct: 1841 RLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLS 1900
Query: 3410 S--------------KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRE 3455
+ ++ + QRQ+++ QV L+ Q + + Q+Q+LE +++ E
Sbjct: 1901 AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQ-LEVDAQQQQLELQQEVE 1959
Query: 3456 SRR 3458
R
Sbjct: 1960 RLR 1962
Score = 159 bits (402), Expect = 5e-38
Identities = 402/1848 (21%), Positives = 753/1848 (40%), Gaps = 245/1848 (13%)
Query: 1569 ISVSSMDASRQLMLNEEQLEDM--RQELVRQYQEHQQATELLRQAHMRQMERQRE-DQEQ 1625
+ + + S L L E + E +Q L++ E Q ++LR+ + Q + Q + D+
Sbjct: 335 VQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKAD 394
Query: 1626 LQEEIKRLNRQLAQRSSIDNENLVSER-ERVLLEELEALKQLSLAGREKLCCELRNSSTQ 1684
L + L + + ++ +NL ++ + L E+LEAL+ L L + L E
Sbjct: 395 LSARVTELGLAVKR---LEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETE------- 444
Query: 1685 TQNGNENQGEVEEQTFKE-KELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTA 1743
GE +QT ++ + + ++ +ER A A+N L+ L +
Sbjct: 445 -------DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTA--DASNGSLRGLSGQRTPSP 495
Query: 1744 AVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDM 1803
+ GR G R S + + S A + S +H+ +V D + D+
Sbjct: 496 PRRSSPGR---GRSPRRGPSPACSD----SSTLALIHSALHKRQLQVQDMRGRYEASQDL 548
Query: 1804 PRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863
S E L ++L R +E+ + RL++A E L S
Sbjct: 549 LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ-RLRSANELLSREKSN 607
Query: 1864 TSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGV 1923
+ L+ A+ Q E +R+ + Q A E L+ Q R+RL EE + V
Sbjct: 608 LAHSLQVAQ-QQAEELRQEREKLQAAQEELRRQ---RDRLEEEQE------------DAV 651
Query: 1924 IDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK--- 1980
DG R+++ +++LE + + L E+ + +R++L +K
Sbjct: 652 QDG-----ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706
Query: 1981 -EAM-KAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI 2038
EA+ KAEAG VE +L KL E+ +Q K+ L + + ++D+ V+
Sbjct: 707 AEALTKAEAGRVELEL--SMTKLRAEEASLQDSLSKL-SALNESLAQDKLDLNRLVA--- 760
Query: 2039 ELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
+LE+EK+ RQ Q E+ + L+E +++E R Q LE L+V
Sbjct: 761 QLEEEKSALQGRQRQAEQEATVAREEQER-LEELRLEQEVAR-------QGLEGSLRVAE 812
Query: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ-LQRDIQERNEEIEKLEFRVRELE 2157
+ Q E Q + + L+E+ + S L +EQ L++ +E ++E LE RE E
Sbjct: 813 QAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKE 872
Query: 2158 QALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE 2217
AK L VQL A +R+ + ++ +L +E
Sbjct: 873 AL---------------------AKEHAGLAVQLVAA----EREGRTLSEEATRLRLEKE 907
Query: 2218 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQH 2277
LE EVQ+ QLE ++++ Q L + ++ L I + ++ D+
Sbjct: 908 ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKE 967
Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD 2337
++ K Q +E + L EQ ++ L+ ++ EK R+LE + L S
Sbjct: 968 LMAQKLVQAEREAQAS---LREQRAAHEEDLQ-----RLQREKEAAWRELEAERAQLQSQ 1019
Query: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTS---MNAHSLSEEADSLKHQLDVVIAE 2394
++R +EE + +L E+L +E+A + Q+ + A S ++A SLK ++E
Sbjct: 1020 ---LQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSE 1076
Query: 2395 KL-ALEQQVETANEEMTFMKNVLK----ETNFKMNQLTQELFSLKRERESV-----EKIQ 2444
KL + T + EM K + + +N LT EL L+ +RE ++++
Sbjct: 1077 KLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR 1136
Query: 2445 SIPENSVNVAI--DHLSKDKPEL--EVVLTEDALKSLENQTYF--KSFEENGKG-SIINL 2497
+ E + ++ D ++ EL ++ L EDA L + + E+ +G +
Sbjct: 1137 RLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQ 1196
Query: 2498 ETRLLQLESTVSAKDLE-LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
E L+ AK+ E L + ++++ ++ E+E + K+ N K E+K+A
Sbjct: 1197 EAGELRRSLGEGAKEREALRRSNEELRSAVKKA--ESERISLKLANEDK--EQKLA---- 1248
Query: 2557 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2616
+ EA K + +T E ER+ ++ +L+E L + L + L ++
Sbjct: 1249 --LLEEARTAVGKEAGELRTGLQEVERSRLEARRELQE--LRRQMKMLDSENTRLGRELA 1304
Query: 2617 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
E+ L L + + + + L ++LL+ + LE ++ + ++K Q+ E
Sbjct: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
Query: 2677 ELFHSNEES------------GFFNELEALRAESVATKAELASYKEKAEKLQEELLVKET 2724
L S EE+ G +LEA RAE+ L++ + +A+ L+ EL E
Sbjct: 1365 RLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEV 1424
Query: 2725 NMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDG 2784
+ + L +R L + L + +A P P+ S + + +G
Sbjct: 1425 QRRAAEAQLGGLRSAL---RRGLGL------------GRAPSPAPRPVPGSPARDAPAEG 1469
Query: 2785 ---------TLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELH 2835
TL+ S +Q P + +L E + E + + + EL
Sbjct: 1470 SGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELR 1529
Query: 2836 A------AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPEL 2889
++ +ME+ S T + R+ AV +E ++ + ++++ +
Sbjct: 1530 TQTSALNRQLAEMEAERDSAT-SRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESV 1588
Query: 2890 AHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE--GRGEESESATDSFPKKIKGLL 2947
S+ + + D + + + T S+ + E + + +E+ + +++K +L
Sbjct: 1589 RRSERERRATL---DQVATLERSLQATESE-LRASQEKISKMKANETKLEGDKRRLKEVL 1644
Query: 2948 RAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREA 3007
A +E V + +GE Q S L +R+A +L+D + +Q Q
Sbjct: 1645 DA--SESRTVKLELQRRSLEGE----LQRSRLGLSDREA---QAQALQDRVDSLQRQ--- 1692
Query: 3008 EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTAL-----GTTDAVGLLN 3062
V DS E+ Q+ +E + LA AL G T+A+ +
Sbjct: 1693 -VADS------------EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSS 1739
Query: 3063 CLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ-EL 3121
+++ + Q A+ + DR+ L + A + ++ R+Q S Q +
Sbjct: 1740 ASLNSTRDKNLHLQKALTACEH-DRQVLQERLDAAR-----QALSEARKQSSSLGEQVQT 1793
Query: 3122 LEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE--LAQTKL-ELETT 3178
L + + Q +E + +L +++ + QE ++ V +L+ E L Q +L L+
Sbjct: 1794 LRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRA 1853
Query: 3179 LKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS---E 3235
L +E+E L ++ + D + E+ +S E L EK +L R+
Sbjct: 1854 LAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGA 1913
Query: 3236 ERDKEELEDLKFSLESQ----KQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEE 3291
E + E + LE+Q +Q + L ++ Q+Q L E QQ++E R AQ E
Sbjct: 1914 ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL-ELQQEVERLR---SAQAQTE 1969
Query: 3292 QGRNLELQVLLESEKVR-IREMSSTLDRERELHAQLQSSDGTGQSRPP 3338
R LE + ++VR + E STL + + + S+ + S PP
Sbjct: 1970 --RTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGPP 2015
Score = 134 bits (337), Expect = 2e-30
Identities = 407/2083 (19%), Positives = 833/2083 (39%), Gaps = 311/2083 (14%)
Query: 439 EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINEL 498
EM +Q + +L++Q ++++E++ + + E + Y+ ++ +Q L
Sbjct: 72 EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQA---------L 122
Query: 499 NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR------EQIQRARQTIA 552
++ + +Q+ + GL+ + L+RQL++ E+ S+ R E QR Q +
Sbjct: 123 RLEPGELETQEPR-----GLV-RQSVELRRQLQE--EQASYRRKLQAYQEGQQRQAQLVQ 174
Query: 553 EQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD 612
+ K+ + K S +E E E ++ + +H ++ + I+LE E++++A L
Sbjct: 175 RLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEE-EQQRSASLA 233
Query: 613 RMAESQEAELERLRT--QLLFSHEEELSKLKEDL-----EIEHRINI-EKLKDNLGIHYK 664
++ +L++ + Q L E++ K+ D E+EHR + +++ ++
Sbjct: 234 QVNAMLREQLDQAGSANQAL---SEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFS 290
Query: 665 ----------QQIDGLQNEMSQKIETMQFEKDNLITKQNQLI----------LEISKLKD 704
+Q+ G + +S E F + +L+ +L L +S
Sbjct: 291 NEHSRLLLLWRQVVGFRRLVS---EVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLR 347
Query: 705 LQQSLVNSKSEEMTLQINELQKEI--EILR---------QEEKEKGTLEQEVQELQLKTE 753
L +S + E+ L +L++++ ++LR Q + +K L V EL L +
Sbjct: 348 LAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVK 407
Query: 754 LLEKQMKEKE---NDLQEKFAQLEA----ENSILKDE-----KKTLEDMLKIHTPVSQEE 801
LEKQ EK+ DL EK LE+ E + L+ E ++TL D+ + +S E
Sbjct: 408 RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQ--AVLSDSE 465
Query: 802 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQR-------NTFSFAE 854
+ L + + S + L + + +R ++ + A
Sbjct: 466 SGVQLSGSERTADAS--NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLAL 523
Query: 855 KNFEVNYQELQ-EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMK 913
+ ++ ++LQ ++ + DL + KQ + +S+ +AL E+ LQR+ T
Sbjct: 524 IHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQ--LQRLRDKTDGAM 581
Query: 914 SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI 973
+ D + V E++ ++ + L L+V +++ EL Q L ++ +
Sbjct: 582 QAHEDAQRE-VQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR 640
Query: 974 SFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGA-- 1031
L EE + Q+ +V RELE +H + E ++ + ++ L V SR
Sbjct: 641 DRLEEEQEDAVQDGARVR---RELE--RSHRQLEQLEGKRSVLAKELVEVREALSRATLQ 695
Query: 1032 ----EGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLI-------------LDH 1074
+ ++V ++ + VE ++S + E S Q+ L LD
Sbjct: 696 RDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDL 755
Query: 1075 LPSVTKESSLRATQPSENDKLQKELNVLKSEQ---NDLRLQMEAQRICLSLVYSTHVDQV 1131
V + ++ + ++E V + EQ +LRL+ E R Q
Sbjct: 756 NRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR------------QG 803
Query: 1132 REYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQ-TMKTQETGDEGKPLHLLIGK 1190
E ++A +L+++L + E+ + +++ QL Q + + QE + +
Sbjct: 804 LEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA 863
Query: 1191 LQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN------EDPELQD 1244
L++A E+ L + + L ++ A ++E G +SE E L+
Sbjct: 864 LERAAREK---------EALAKEHA-GLAVQLVAAERE--GRTLSEEATRLRLEKEALEG 911
Query: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSK---------IWGQQTDGMKLEFGEE 1295
+EVQ + ++ E LL+ + L+ I Q+ + E +
Sbjct: 912 SLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQ 971
Query: 1296 NLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLK 1355
L + E E +L + H+ L LQ ++ E E L S LQ++ +
Sbjct: 972 KLVQAERE------AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQE 1025
Query: 1356 ETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTM----YPGSCVKKNID 1411
E EAE L + + A+ + + +++ ES+ Q+ + + + + +
Sbjct: 1026 ELLARLEAEKEELSEEIAALQQER------DEGLLLAESEKQQALSLKESEKTALSEKLM 1079
Query: 1412 GTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENT 1471
GT ++ E + + Q +++ + + S Q E + + +E
Sbjct: 1080 GTRHSLATISLEMER---QKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR 1136
Query: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGE--HGKEIL 1529
+QA + +Q E + + Q+ + E + E ++L E G+E+
Sbjct: 1137 RLQEQARDLGKQRDSCLREAEELRTQL--RLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194
Query: 1530 LSNSDP-----HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE 1584
+ + + ++ + +EE+ S K +S + +++ D ++L L E
Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEELRSAVKK---AESERISLKLANEDKEQKLALLE 1251
Query: 1585 EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSID 1644
E + +E + + Q E R R+++ R + L E RL R+LA+ +
Sbjct: 1252 EARTAVGKE-AGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE---LQ 1307
Query: 1645 NENLVSER-ERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEK 1703
+ ER E+ E L+Q L G L E+ Q Q +++EQ + +
Sbjct: 1308 GRLALGERAEKESRRETLGLRQRLLKGEASL--EVMRQELQVA-----QRKLQEQEGEFR 1360
Query: 1704 ELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSS-- 1761
+R+ E E+ L A R L++ LE + AA +G + R+
Sbjct: 1361 TRERRLLGSLEEARGTEKQQLDHA--RGLELKLEAARAEAA---ELGLRLSAAEGRAQGL 1415
Query: 1762 KSQSSASLIWRSEAEA---SVKSCVHE-----EHTRVTDESIPSYSGSDMPR----NDIN 1809
+++ + + R AEA ++S + +P D P +N
Sbjct: 1416 EAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLN 1475
Query: 1810 MWSKV-TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQL 1868
S + G++ + A ++DPE ++ A+ + L+ + +
Sbjct: 1476 SPSTLECSPGSQPPSPGPATSPASPDLDPE----------AVRGALREFLQELRSAQRER 1525
Query: 1869 EHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA 1928
+ + + L R+ + E + +L++ + E AR + +G + G
Sbjct: 1526 DELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSV-------DGRLSGVQ 1578
Query: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988
E L E ++ R E+E +++ LE Q E EL + Q++ K +A
Sbjct: 1579 AELALQEESVR-------RSERERRATLDQVATLERSLQ--ATESELRASQEKISKMKAN 1629
Query: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048
+ L+ ++ +KE L+ ++ V+ +LQ+ ++LE ++ Q L
Sbjct: 1630 ETK---LEGDKRRLKEVLDAS-ESRTVKLELQR--RSLEGEL-----------QRSRLGL 1672
Query: 2049 MDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQT 2108
D Q QAL+ +++ +++ Q D E + Q +++L L V + +
Sbjct: 1673 SDREAQAQALQDRVDSLQR----QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKV 1728
Query: 2109 REV-EQLA------NHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161
R + E LA N ++K + L + E ++ +QER L+ + L +A
Sbjct: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER------LDAARQALSEARK 1782
Query: 2162 VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK---EKEITNLEEQLEQFREE 2218
S+ ++V+ + A + E QLQ R+ + ++ E N ++L+ R
Sbjct: 1783 QSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL 1842
Query: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
L+ + +Q+ QLE +K+E LE++ + ++K ++ S +D
Sbjct: 1843 LQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDK----VEREKLRSHEDTVR 1898
Query: 2279 LFGKFAQI----------IQEKEVEIDQLNEQVTKLQQ-----QLKITTDNKVIEEKNEL 2323
L + ++ + E + +I QL QV L+Q QL++ + +E + E+
Sbjct: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
Query: 2324 --IRDLETQIECLMSDQECVKRNREEEI-EQLNEVIEKLQQEL 2363
+R + Q E + +E R R + EQ++ + +LQQEL
Sbjct: 1959 ERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001
Score = 119 bits (297), Expect = 8e-26
Identities = 222/1024 (21%), Positives = 414/1024 (40%), Gaps = 162/1024 (15%)
Query: 25 AQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPESTIM 84
AQ QS K + + V N+++ Q N+ + +ES + E +
Sbjct: 382 AQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL 441
Query: 85 RT------------LHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTN 132
T L ++ E G + S TAD + + G S RT P
Sbjct: 442 ETEDGEGLQQTLRDLAQAVLSDSESGVQL---SGSERTADASNGSLRGLSG-QRTPSPPR 497
Query: 133 LLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQ 192
DS T L ++ S L +Q +++++ E + GT +Q
Sbjct: 498 RSSPGRGRSPRRGPSPACSDSST-LALIHSALHKRQLQVQDMRGRYEASQDLLGTLR-KQ 555
Query: 193 LQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLR 252
L + E+ + L LQ+ R + D M+ + + Q+L+ A+E L
Sbjct: 556 LSDSESERRA-------LEEQLQRLRDKTDGAMQAHEDAQREVQRLR------SANELL- 601
Query: 253 NSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQ 312
S S A LQ QQ Q EE E Q +E+ Q L+E EQ
Sbjct: 602 -SREKSNLAHSLQVAQQ------QAEELRQEREKLQAAQEELRRQRDRLEE-------EQ 647
Query: 313 DKKVENSNK--EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
+ V++ + E++ +E+L K K+ +E+++ L+ A LQ + +
Sbjct: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVA 707
Query: 371 Q-----EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425
+ E ++LEL+ +K + ++S L ++ +L N +Q + D+
Sbjct: 708 EALTKAEAGRVELELSMTKLRAEEAS-----LQDSLSKLSALNESLAQDKLDL------- 755
Query: 426 TQRKLEQLRAELDEMYGQQIVQMKQE--LIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
R + QL E + G+Q Q +QE + R+ ++EE++ +
Sbjct: 756 -NRLVAQLEEEKSALQGRQR-QAEQEATVAREEQERLEELRLEQE--------------- 798
Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543
VA L L+ +E L+++L + E+ LQ QL L +LS ++
Sbjct: 799 ---------VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849
Query: 544 IQRARQTIAEQESKLNEAHKSLSTVED----LKAEIVSA-------SESRKELELKHEA- 591
+++AR+ Q L A + + L ++V+A SE L L+ EA
Sbjct: 850 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 909
Query: 592 ---------EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKE 642
++ + + E LE E A+L E+ EL LR Q++ + E+ + L +
Sbjct: 910 EGSLFEVQRQLAQLEARREQLEAEGQALL-LAKETLTGELAGLRQQIIATQEK--ASLDK 966
Query: 643 DLEIEHRINIEK-----LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
+L + + E+ L++ H ++ + LQ E ++ E+ L Q+QL
Sbjct: 967 ELMAQKLVQAEREAQASLREQRAAH-EEDLQRLQREKEAAWRELEAERAQL---QSQLQR 1022
Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIE---ILRQEEKEKGTLEQEVQELQLKTEL 754
E +L + + ++ EE++ +I LQ+E + +L + EK++ +E ++ L +L
Sbjct: 1023 EQEELL----ARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 1078
Query: 755 L-------------EKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801
+ E+Q ++ ++ ++ + + A S L+D + E+ H +QE
Sbjct: 1079 MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH---AQEV 1135
Query: 802 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
R ++ +++D K+ + + E E+L+ Q L + + R A++
Sbjct: 1136 R-----RLQEQARDL--GKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKL---- 1184
Query: 862 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921
+E QE + +L S + E + L+ NEEL + ++ + +EDK
Sbjct: 1185 RESQEGREVQRQEAGELRRSLGEGAKE-REALRRSNEELRSAVKKAESERISLKLANEDK 1243
Query: 922 TFVAETLEMGEV-VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980
LE V K+ EL L+ +R +LE + L +L Q+K E + L E+
Sbjct: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303
Query: 981 KSLK 984
L+
Sbjct: 1304 AELQ 1307
Score = 116 bits (290), Expect = 5e-25
Identities = 397/1955 (20%), Positives = 784/1955 (40%), Gaps = 289/1955 (14%)
Query: 1988 GPVEQQLLQETEKLMKEKLE--VQCQAEKV--RDDLQK-QVKALEIDVEEQVSRFIE--- 2039
G Q ++ T + + + LE V CQ + + RD Q Q+ +L + E V+R +
Sbjct: 4 GLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPE 63
Query: 2040 ----LEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
L + L+ L+++NQ L+++L ++ L + +R+ + ++LEQ L+
Sbjct: 64 SPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALR 123
Query: 2096 VVPRFQPISEHQ--TREVEQLANHLKEKTDKCSELLLSKEQLQRD----IQERNEEIEKL 2149
+ P E + R+ +L L+E+ L + ++ Q+ +Q +I +
Sbjct: 124 LEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY 183
Query: 2150 EFRVRELEQALLVSADTF--QKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITN 2207
+ R ELEQ LL + Q++ D +H +E S ++L+ E+ +
Sbjct: 184 KKRCSELEQQLLERSGELEQQRLRDTEHSQDLE-----SALIRLEEEQQRSASLAQVNAM 238
Query: 2208 LEEQLEQFREELENKNEEVQQL-----HMQLEIQKKESTTRLQELEQENKLFKDDMEKLG 2262
L EQL+Q + +E+++++ + E++ +E+ R +E E N F ++ +L
Sbjct: 239 LREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE-ESFNAYFSNEHSRLL 297
Query: 2263 L----------AIKESDAMSTQDQHVLFGKFA---QIIQE-----------KEVEIDQLN 2298
L + E + +D L G+ A + +QE E +
Sbjct: 298 LLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAAL 357
Query: 2299 EQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2358
E+ LQ QL+ +KV+ EK+ + +++ ++ K + + +L +++
Sbjct: 358 EKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLD---------KADLSARVTELGLAVKR 408
Query: 2359 LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2418
L+++ N+ +K +N L+E+ ++L E L L++Q E+ ++ L
Sbjct: 409 LEKQ--NL-EKDQVN-KDLTEKLEAL---------ESLRLQEQAALETEDGEGLQQTL-- 453
Query: 2419 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2478
R+ + + S E+ V ++ + D + +L+ L
Sbjct: 454 ------------------RDLAQAVLSDSESGVQLSGSERTAD-------ASNGSLRGLS 488
Query: 2479 NQTYFKSFEENGKG---SIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEM 2535
Q + G S + ST++ L + Q++DM +G++E
Sbjct: 489 GQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDM--RGRYEAS- 545
Query: 2536 LQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED 2595
Q + L+K + + + + QL+ +++ D + E + +Q L E
Sbjct: 546 -QDLLGTLRKQLSDSESERRALEEQLQRLRDKT----DGAMQAHEDAQREVQRLRSANE- 599
Query: 2596 ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE---------- 2645
L + S L + + Q E+ E+E+++ A++ + + +L E
Sbjct: 600 LLSREKSNLAHSLQVAQQQAEELRQ----EREKLQAAQEELRRQRDRLEEEQEDAVQDGA 655
Query: 2646 -LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEA------LRAES 2698
+++ LE + ++ + E KRS E+++ L + + +A +AE+
Sbjct: 656 RVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEA 715
Query: 2699 VATKAELASYKEKAEK--LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2756
+ EL+ K +AE+ LQ+ L SL +D + +A+ +E+ S L+
Sbjct: 716 GRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQ 775
Query: 2757 EVQESKKACMFEPL--PIKLSKSIASQ-TDGTLKISSSNQTPQILVKNAGIQINLQSECS 2813
QE+ A + ++L + +A Q +G+L++ + Q + L + + +S+
Sbjct: 776 AEQEATVAREEQERLEELRLEQEVARQGLEGSLRV--AEQAQEALEQQLPTLRHERSQL- 832
Query: 2814 SEEVTEIISQFTEKIEKMQEL--HAAEILDMESRHISETETLKREHY-VAVQL------- 2863
E++ ++ Q + + +++++ A ++ R E E L +EH +AVQL
Sbjct: 833 QEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREG 892
Query: 2864 --LKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF 2921
L EE L+ + L +LA +A RE ++ GQ + L
Sbjct: 893 RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEA--RREQLEAE-----GQALLLAKE--- 942
Query: 2922 DIASEGRG-EESESATDSFPKKIKGLL--RAVHNEGMQVLSLTESPYSDGED-HSIQQVS 2977
+ E G + AT K L+ + V E SL E + ED +Q+
Sbjct: 943 TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK 1002
Query: 2978 E-PWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLE 3036
E W E S L+ ++ + EAE + S+ + R E LL +
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE----S 1058
Query: 3037 ERSVLLAAFRTELTAL-----GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLL 3091
E+ L+ +E TAL GT ++ ++ LE Q++ + + + ++ +L
Sbjct: 1059 EKQQALSLKESEKTALSEKLMGTRHSLATIS-LEMERQKRDAQSRQEQD---RSTVNALT 1114
Query: 3092 SEIQALHAQ------MNGRKITLKREQESEKPSQE---LLEYNIQQKQSQMLE-----MQ 3137
SE++ L AQ + +++ +EQ + Q L E + Q ++LE ++
Sbjct: 1115 SELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLR 1174
Query: 3138 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK---HLKELEAFRL 3194
EL + + E QE ++ EL+ L + E E ++ + +K+ E+ R+
Sbjct: 1175 RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI 1234
Query: 3195 EVK----DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLE 3250
+K DK ++ LL + + K++ EL+ L+ ++ RS + EL++L+ ++
Sbjct: 1235 SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ----EVERSRLEARRELQELRRQMK 1290
Query: 3251 SQKQRNLQLNL-LLEQQKQLLNESQQKIESQRM---LYDAQLSEEQGRNLELQVLLESEK 3306
N +L L E Q +L + + ES+R L L E + Q L +++
Sbjct: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR 1350
Query: 3307 VRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK---------ELQKQLEEKHS 3357
+ RER L L+ + GT + + LK EL +L
Sbjct: 1351 KLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG 1410
Query: 3358 RIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL---------------QTEQEANTEGQ 3402
R L E + ++ Q+ R R+ L ++A EG
Sbjct: 1411 RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGS 1470
Query: 3403 KKMHELQSKVE---DLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI 3459
+ S +E Q DL+ + ++G ++EF ++ + +R+ R
Sbjct: 1471 GEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRT 1530
Query: 3460 LYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM----- 3514
LN + ++R ++++ ES A+ ++G +G EL +
Sbjct: 1531 QTSALNRQLA-EMEAERDSATSRARQLQKAVAESEEARR-SVDGRLSGVQAELALQEESV 1588
Query: 3515 ----------------IRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENID--- 3555
+ + LQ S+L+ +K S+ ET + D ++E +D
Sbjct: 1589 RRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASE 1648
Query: 3556 ----EIILQLQKLTGQ-QGEEPSLVSPSTSCGSLTER---LLRQ--NAELTGHISQLTEE 3605
++ LQ + L G+ Q L +L +R L RQ ++E+ QLT E
Sbjct: 1649 SRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVE 1708
Query: 3606 KNDLRNMVMKLEEQIRWYRQTGAGRDNS---SRFSLNGGANIEAIIASEKEVWNREKLTL 3662
+ L + K+EE R G + S SLN + + ++ L
Sbjct: 1709 R--LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL 1766
Query: 3663 QKSL---KRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQK 3719
Q+ L ++A +E K + L +QTL + + L+R+ + + + R+ L ++
Sbjct: 1767 QERLDAARQALSEARKQSSSLGEQ--VQTLRGEVADLELQRVEAEG-QLQQLREVLRQRQ 1823
Query: 3720 KYLLLLLGGFQECEDATLALLARMGG-QPAFTDLE 3753
+ L Q+ +D L R+G Q A LE
Sbjct: 1824 EGEAAALNTVQKLQDERRLLQERLGSLQRALAQLE 1858
Score = 113 bits (283), Expect = 3e-24
Identities = 293/1529 (19%), Positives = 623/1529 (40%), Gaps = 179/1529 (11%)
Query: 1335 KLEEQVQEL-------ESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVD 1387
K + QVQ++ + L+ +L++QL ++E +E L+++LQ + + T D
Sbjct: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSE----SERRALEEQLQRLRDKT-------D 578
Query: 1388 SVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLE--KQYQEQLEEEVA 1445
+ DAQR + + + E +E++N+ L+ +Q E+L +E
Sbjct: 579 GAMQAHEDAQREVQ-----------RLRSANELLSREKSNLAHSLQVAQQQAEELRQERE 627
Query: 1446 KVIVSMSIAFAQQTELSR-----ISGGKENTASSKQAHAVCQQEQ--------------H 1486
K+ + Q+ L + G +++H +Q +
Sbjct: 628 KLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVRE 687
Query: 1487 YFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL 1546
+ L +D + + E + K E + EL + ++ + +S +
Sbjct: 688 ALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELS-----MTKLRAEEASLQDSLSKLS 742
Query: 1547 TISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE--------EQLEDMR--QELVR 1596
++E + ++DK + R E S++ ++ E E+LE++R QE+ R
Sbjct: 743 ALNESL-AQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR 801
Query: 1597 QYQEHQ-QATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655
Q E + E ++A +Q+ R ++ QLQE++ +L+RQL+ R E + + R
Sbjct: 802 QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGR-----EQELEQARRE 856
Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQ-NGNENQGEVEEQTFKEKELDRKPEDVPP 1714
++EAL++ A REK ++ Q E +G + L++ E +
Sbjct: 857 AQRQVEALER---AAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEK--EALEG 911
Query: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774
+ +R Q R + L + +ET+ + G+ + +Q ASL
Sbjct: 912 SLFEVQRQLAQLEARR--EQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 969
Query: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR-SGFAGT 1833
A+ V++ + + + + R W ++ E +L +L R
Sbjct: 970 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA 1029
Query: 1834 EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-ATES 1892
++ E EEL I++ Q E LL A SE L + +T L + + AT S
Sbjct: 1030 RLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS 1089
Query: 1893 LKCQEELRE---RLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLE 1949
L+ + + R+ R ++ L EL + A R++QE+ + +
Sbjct: 1090 LEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQR 1149
Query: 1950 QELLCASNRLQELEAEQQQIQE-----ERELLSRQKEAMKAEAG-PVEQQLLQETEKLMK 2003
L +EL + + +++ RELL Q++ +++ G V++Q E + +
Sbjct: 1150 DSCL---REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLG 1206
Query: 2004 EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063
E + + + ++L+ VK E E++S + ++K +L L + A+ K+
Sbjct: 1207 EGAKEREALRRSNEELRSAVKKAE---SERISLKL-ANEDKEQKLALLEEARTAVGKEAG 1262
Query: 2064 KMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL----- 2118
++R L E E R ++E+Q+L +Q+K++ + RE+ +L L
Sbjct: 1263 ELRTGLQEV----ERSRLEARRELQELRRQMKML---DSENTRLGRELAELQGRLALGER 1315
Query: 2119 KEKTDKCSELLL---------SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQK 2169
EK + L L S E +++++Q ++++ E R E+ LL S + +
Sbjct: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARG 1375
Query: 2170 VEDRK--HFGAVEAKPELS------LEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2221
E ++ H +E K E + L ++L A E E+ +E Q +L
Sbjct: 1376 TEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG 1435
Query: 2222 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 2281
L L + + S + + GL + S Q G
Sbjct: 1436 LR---SALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492
Query: 2282 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 2341
A +++ + + + + Q+L+ E++EL R + + +++ E
Sbjct: 1493 P-ATSPASPDLDPEAVRGALREFLQELR-----SAQRERDEL-RTQTSALNRQLAEMEAE 1545
Query: 2342 KRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQ 2401
+ + QL + + + ++ ++ + S L+ + +S++ E+ A Q
Sbjct: 1546 RDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS----ERERRATLDQ 1601
Query: 2402 VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2461
V T + ++ L+ + K++++ L+ ++ ++++ E+ L
Sbjct: 1602 VATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRT----VKLELQ 1657
Query: 2462 KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ 2521
+ LE L L + + ++ ++ + +L+ ++ +S V A L+LT ++
Sbjct: 1658 RRSLEGELQRSRLGLSDREAQAQALQDR----VDSLQRQV--ADSEVKAGTLQLT--VER 1709
Query: 2522 IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2581
+ + + L+ K+ L + + + A+ ++ + +Q+ C+ ++ + E
Sbjct: 1710 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER 1769
Query: 2582 ERTNIQNLNQLRE--DELGSDISALTLRISELESQVVEMHTSL------ILEKEQVEIAE 2633
Q L++ R+ LG + L +++LE Q VE L + ++++ E A
Sbjct: 1770 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAA 1829
Query: 2634 KNVLEK---EKKLLE-----LQKLLEGNEKKQREKEKK--RSPQDVEVLKTT-----TEL 2678
N ++K E++LL+ LQ+ L E ++RE E+ R +D L+ T E
Sbjct: 1830 LNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREK 1889
Query: 2679 FHSNEESGFFN-ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT--SLQKDLSQ 2735
S+E++ + E L + ELA + + ++L+ +++V E + + L+ D Q
Sbjct: 1890 LRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQ 1949
Query: 2736 VRDHLAEAKEKLSILEKEDETEVQESKKA 2764
+ L + E+L + + E ++ ++A
Sbjct: 1950 QQLELQQEVERLRSAQAQTERTLEARERA 1978
Score = 110 bits (275), Expect = 3e-23
Identities = 282/1401 (20%), Positives = 546/1401 (38%), Gaps = 149/1401 (10%)
Query: 31 SPSKKQKKKRKTSSSKHDVSA----HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRT 86
SP + + +R S + D S H L+ Q Q +M R E++ T+ +
Sbjct: 500 SPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDM----RGRYEASQDLLGTLRKQ 555
Query: 87 LHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYS 146
L E S + +L+ T + + V R LL E+ + ++S
Sbjct: 556 LSDSE--SERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNL--AHS 611
Query: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
Q AQ L +L Q E+ LEE + +G + +E E + +Q
Sbjct: 612 LQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ---- 667
Query: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQA-----SETLRNSTHSSTAA 261
L+Q ++ +E +E+ E + +Q LQA +E L +
Sbjct: 668 -------LEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL 720
Query: 262 DLLQAKQQI--LTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE-----MEQDK 314
+L K + + Q L + L E + K D ++ L+E+ + EQ+
Sbjct: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA 780
Query: 315 KVENSNKEEIQE----KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
V +E ++E +E + L + E+ L+ +L T +LQEQ+ Q +
Sbjct: 781 TVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
Query: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKL 430
+++ + EL ++++ ++ E +++ E L K H + +R + +
Sbjct: 841 RQLSGREQELEQARREAQRQVEALERAAREKEALAK-EHAGLAVQLVAAEREGRTLSEEA 899
Query: 431 EQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL 490
+LR E + + G +++ +AQ+E + + + E + L + +T ++
Sbjct: 900 TRLRLEKEALEGSLFE------VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
Query: 491 MNVAINELNIKLQDTNSQK---------EKLKEELGLILEEKCALQRQLEDLVEELSFSR 541
+A E ++ +QK L+E+ E+ LQR+ E EL R
Sbjct: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Query: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Q+Q Q E+ EA K E+L EI + + R E L E+E L
Sbjct: 1014 AQLQSQLQREQEELLARLEAEK-----EELSEEIAALQQERDEGLLLAESEKQQ---ALS 1065
Query: 602 MLEKEKNAVLDRMAESQEA------ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKL 655
+ E EK A+ +++ ++ + E+ER + E++ S + L E R ++
Sbjct: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA-LTSELR-DLRAQ 1123
Query: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715
++ + Q++ LQ ++ + ++D+ + + +L ++ L+D + L +
Sbjct: 1124 REEAAAAHAQEVRRLQ----EQARDLGKQRDSCLREAEELRTQLRLLEDARDGL-RRELL 1178
Query: 716 EMTLQINELQKEIEILRQE----EKEKGTLEQEVQELQLKTELLEKQMKEKEND-LQEKF 770
E ++ E Q+ E+ RQE + G +E + L+ E L +K+ E++ + K
Sbjct: 1179 EAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKL 1238
Query: 771 AQLEAENSI-LKDEKKTL--EDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIE 827
A + E + L +E +T ++ ++ T + + ER ++++ + +++++L
Sbjct: 1239 ANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER----SRLEARRELQELRRQMKMLDS 1294
Query: 828 ENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK--- 884
EN L ++ +L + + + Q L + A L ++ +L+ ++ K
Sbjct: 1295 ENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
Query: 885 QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEK 944
QE E++++ + L L R ++ + A LE+ K
Sbjct: 1355 QEGEFRTRERRLLGSLEEARGT-----------EKQQLDHARGLEL-------------K 1390
Query: 945 LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004
LE + E EL RLS + + E++ EV+ E + LR L +
Sbjct: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELA--RVEVQRRAAEAQLGGLR-SALRRGLGLG 1447
Query: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064
RA + S D AEGS +N E + +
Sbjct: 1448 RAPSPAPRPVPGSPARDA-------PAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
Query: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124
+ + L +E LR+ Q E D+L+ + + L N +MEA+R +
Sbjct: 1501 DLDPEAVRGALREFLQE--LRSAQ-RERDELRTQTSAL----NRQLAEMEAERDSATSRA 1553
Query: 1125 STHVDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKT-----QET 1177
V E E + D L ++ EL QEE ++ ++ + L + T Q T
Sbjct: 1554 RQLQKAVAESEEARRSVDGRLSGVQAELAL-QEESVRRSERERRATLDQVATLERSLQAT 1612
Query: 1178 GDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN 1237
E + I K+ KA + + L VL + +K E+ E +
Sbjct: 1613 ESELRASQEKISKM-KANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGE----LQR 1667
Query: 1238 EDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENL 1297
L D + Q Q+ + +L +V + K LQ + ++ G + E +
Sbjct: 1668 SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDK 1727
Query: 1298 PKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQ---L 1354
+ TE L+ S N H K + + ++ L+E++ +S ++Q L
Sbjct: 1728 VRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSL 1787
Query: 1355 KETEQNYEAEIHCLQ-KRLQA 1374
E Q E+ L+ +R++A
Sbjct: 1788 GEQVQTLRGEVADLELQRVEA 1808
Score = 100 bits (248), Expect = 4e-20
Identities = 269/1416 (18%), Positives = 555/1416 (39%), Gaps = 177/1416 (12%)
Query: 190 LQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQ-SQKLQIQFQQLQAS 248
L LQE ++Q + L A Q+R E+DE ++ ++E+ Q L+++ +L+
Sbjct: 76 LLSLQEENQLLQQELSRVEDLLA---QSRAERDELAIKYNAVSERLEQALRLEPGELETQ 132
Query: 249 ETLRNSTHSSTAADLLQAKQ-----QILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQE 303
E S LQ +Q ++ +Q+ + Q L++ Q K + + S L++
Sbjct: 133 EPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQ 192
Query: 304 KI--KVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361
++ + E+EQ + + + ++++ +EE + + L+++L A
Sbjct: 193 QLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQA 252
Query: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421
L E I + + + EL + + R+ E + +V
Sbjct: 253 LSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSE 312
Query: 422 MEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNI 481
++ T+R L QL EL + + QE + ++R + +E + +
Sbjct: 313 VKMFTERDLLQLGGEL-----ARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQL 367
Query: 482 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLK-----EELGLILE-------EKCALQRQ 529
E+Q++ + + E ++ Q S +K ELGL ++ EK + +
Sbjct: 368 ---EEQLR--DKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKD 422
Query: 530 LEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE-LK 588
L + +E L R Q Q A +T + T+ DL ++S SES +L +
Sbjct: 423 LTEKLEALESLRLQEQAALET--------EDGEGLQQTLRDLAQAVLSDSESGVQLSGSE 474
Query: 589 HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL-----KED 643
A+ +N ++ L ++ R + R S L+ + K
Sbjct: 475 RTADASNGSLR--GLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQ 532
Query: 644 LEIEH-RINIEKLKDNLGIHYKQQIDGLQNE--MSQKIETMQFEKDNLITKQNQLILEIS 700
L+++ R E +D LG KQ D + ++++ ++ + D + E+
Sbjct: 533 LQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ 592
Query: 701 KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMK 760
+L+ + L KS + + Q++ E LRQE ++ L+ +EL+ + + LE++ +
Sbjct: 593 RLRSANELLSREKSN-LAHSLQVAQQQAEELRQEREK---LQAAQEELRRQRDRLEEEQE 648
Query: 761 EKEND----------LQEKFAQLEAENSILKDE---------KKTLE-DMLKIH------ 794
+ D + QLE + S+L E + TL+ DML+
Sbjct: 649 DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAE 708
Query: 795 --TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNE---EIEKQRNT 849
T + L K +++++ + + L NE L Q + LN ++E++++
Sbjct: 709 ALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSA 768
Query: 850 FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTT 909
++ E +EE L +++ LE +Q LE ++ +E Q++ T
Sbjct: 769 LQGRQRQAEQEATVAREEQERLEELR--LEQEVARQGLEGSLRVAEQAQEALEQQL--PT 824
Query: 910 VKMKSSVFDEDKTFVAETL----EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ 965
++ + S E ++ L + E ++ +E LE REK L++ + L+ Q
Sbjct: 825 LRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ 884
Query: 966 LKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025
L E L+EE L+ EKE + E++ + A Q + + +LL T
Sbjct: 885 LVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQ-LEAEGQALLLAKET 943
Query: 1026 MTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLR 1085
+T G ++ + + I ++K S + + ++ Q + ++SLR
Sbjct: 944 LT-----GELAGLRQQI-----IATQEKASLDKELMAQKLVQAER--------EAQASLR 985
Query: 1086 ATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCS 1145
+ + + LQ+ L+ E+ ++EA+R L +++ +E EK++
Sbjct: 986 EQRAAHEEDLQR----LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEE---- 1037
Query: 1146 LKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQT 1205
L EE+ Q+E+ + L + Q + +E+ + A+SE+ +
Sbjct: 1038 LSEEIAALQQERDEGLLLAESEKQQALSLKESE-------------KTALSEKLMGTRHS 1084
Query: 1206 LCSVLGEYYTPALKCEVNAE-DKENSGDYISENEDPELQ------DYRYEVQDFQENMHT 1258
L ++ E + E D+ SE D Q + EV+ QE
Sbjct: 1085 LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARD 1144
Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-ENLPKEETEFLSIHSQMTNLEDI 1317
L + + L+T+L ++ DG++ E E + +E E + Q
Sbjct: 1145 LGKQRDSCLREAEELRTQL-RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203
Query: 1318 DVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQ---LKETEQNYEAEIHCLQKRLQA 1374
+ +K E+ L +EL S + + + LK ++ E ++ L++ A
Sbjct: 1204 SLGEGAK-------EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTA 1256
Query: 1375 VSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEK 1434
V + + V + +A+R + +E +K+L+
Sbjct: 1257 VGKEAGELRTGLQEVERSRLEARREL----------------------QELRRQMKMLDS 1294
Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494
+ +L E+A++ +++ + E R + G +A +++ + KL
Sbjct: 1295 E-NTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQ 1353
Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILL 1530
+ + F+T E + EE + K+ +H + + L
Sbjct: 1354 EQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLEL 1389
Score = 90.9 bits (224), Expect = 2e-17
Identities = 208/1106 (18%), Positives = 450/1106 (40%), Gaps = 137/1106 (12%)
Query: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQ-EFEAAIKQRDGIITQLTANLQQ 216
E+M +L + E + L E R + E LQ+LQ E EAA ++ + QL + LQ+
Sbjct: 967 ELMAQKLVQAEREAQA---SLREQRAAH-EEDLQRLQREKEAAWRELEAERAQLQSQLQR 1022
Query: 217 ARRE--------KDETMREFLELT-EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK 267
+ E K+E E L E+ + L + + Q + +L+ S ++ + L+ +
Sbjct: 1023 EQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTR 1082
Query: 268 QQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----------KKVE 317
+ T ++E Q D Q ++E ++ L +++ +++ ++++
Sbjct: 1083 HSLATISLEMERQKR---DAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQ 1139
Query: 318 NSNKEEIQEKETII---EELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK 374
++ +++++ + EEL T++ E L+ +L A + L E QE + QE
Sbjct: 1140 EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199
Query: 375 NMKLEL-TNSKQKE--RQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQR 428
++ L +K++E R+S+EE++ + E + K ++D + + +++ +
Sbjct: 1200 ELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK 1259
Query: 429 KLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQMEEMKTRHKGEM----------ENALR 476
+ +LR L E+ ++ + ++EL +R+ M ++ TR E+ E A +
Sbjct: 1260 EAGELRTGLQEVERSRL-EARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEK 1318
Query: 477 SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE 536
T+ Q L A L + Q+ + KL+E+ G E + +R L L E
Sbjct: 1319 ESRRETLGLRQRLLKGEA--SLEVMRQELQVAQRKLQEQEG---EFRTRERRLLGSLEEA 1373
Query: 537 LSFSREQIQRARQTIAEQESKLNEAHK---SLSTVEDLKAEIVSASESRKELELKH-EAE 592
++Q+ AR + E+ EA + LS E +A+ + A +R E++ + EA+
Sbjct: 1374 RGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG-RAQGLEAELARVEVQRRAAEAQ 1432
Query: 593 VTNYKIKLEM------------LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640
+ + L + D AE L T + S
Sbjct: 1433 LGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492
Query: 641 KEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNE----------MSQKIETMQFEKDNLIT 690
++ E ++ L + Q++ Q E +++++ M+ E+D+ +
Sbjct: 1493 PATSPASPDLDPEAVRGALR-EFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATS 1551
Query: 691 KQNQLILEISKLKDLQQSL---VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747
+ QL +++ ++ ++S+ ++ E+ LQ E + R E + + TL+Q
Sbjct: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQ------EESVRRSERERRATLDQ---- 1601
Query: 748 LQLKTELLEKQMKEKENDL---QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLI 804
LE+ ++ E++L QEK ++++A + L+ +K+ L+++L + E R +
Sbjct: 1602 ----VATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLD-----ASESRTV 1652
Query: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
L+ + + + + + D + Q L + ++ + + +E +
Sbjct: 1653 KLELQRRSLEGELQRSRLGL-----SDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTV 1707
Query: 865 QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFV 924
+ L KV++ E + K++ L E L + + + K+ + T
Sbjct: 1708 ERLNGALAKVEES--------EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALT-- 1757
Query: 925 AETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984
E D L E+L+ ++ E ++ S L EQ++ GE++ L + +
Sbjct: 1758 --------ACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAE 1809
Query: 985 QEKEQVS--LRCRELEIIINHNRAENVQS----CDTQVSSLLDGVVTMTSRGAEGSVSKV 1038
+ +Q+ LR R+ N + +Q ++ SL + + + E S +
Sbjct: 1810 GQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSAL 1869
Query: 1039 NKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEN-DKLQK 1097
+ DKV E + E++ + L + L + +L+
Sbjct: 1870 RLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEA 1929
Query: 1098 ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK 1157
++ VL+ + +L+++AQ+ L L + + +A + + EE+
Sbjct: 1930 QVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQ 1989
Query: 1158 IKELQKIHQLELQTMKTQETGDEGKP 1183
+ L+ Q EL+ + G P
Sbjct: 1990 VSTLKGQLQQELRRSSAPFSPPSGPP 2015
Score = 78.6 bits (192), Expect = 1e-13
Identities = 204/1099 (18%), Positives = 443/1099 (40%), Gaps = 154/1099 (14%)
Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
E E ++LEA +A+L QR+ + + ++ + +K + S + D + ++
Sbjct: 1001 EKEAAWRELEAERAQLQSQLQREQE---ELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
Query: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
+ S + E T + E +M T HS S E + + + + S VN
Sbjct: 1058 SEKQQALSLKESEKTALSEK-LMGTRHSLATISLEME---RQKRDAQSRQEQDRSTVNAL 1113
Query: 122 SFVMRT------------GKPTNLLREE--EFGVDDSYSEQGAQDSPTHLEMMESELAGK 167
+ +R + L+E+ + G + A++ T L ++E G
Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173
Query: 168 QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227
+ E+ E R+L E + EG +++Q EA +R A ++A R +E +R
Sbjct: 1174 RRELLEAQRKLRESQ-----EG-REVQRQEAGELRRS---LGEGAKEREALRRSNEELRS 1224
Query: 228 FLELTEQSQKLQIQF------QQLQASETLRNSTHSSTAADLLQAKQQI----LTHQQQL 277
++ E S+++ ++ Q+L E R + A +L Q++ L +++L
Sbjct: 1225 AVKKAE-SERISLKLANEDKEQKLALLEEARTAV-GKEAGELRTGLQEVERSRLEARREL 1282
Query: 278 EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEM-EQDKKVENSN-KEEIQEKETIIEELN 335
+E ++ + +++ LQ ++ + E E++ + E ++ + + E +E +
Sbjct: 1283 QELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMR 1342
Query: 336 TKIIEEEKKTLELKDKLTTADK-LLGELQEQIVQKNQEI---KNMKLELTNSKQKERQSS 391
++ ++K E + + T ++ LLG L+E + Q++ + ++L+L ++ + +
Sbjct: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELG 1402
Query: 392 EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDE------------ 439
+ G + L+ ++ VQR E Q L LR+ L
Sbjct: 1403 LRLSAAEGRAQGLE------AELARVEVQRRAAEAQ--LGGLRSALRRGLGLGRAPSPAP 1454
Query: 440 --MYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINE 497
+ G E + + ++ + + + S + + D + + A+ E
Sbjct: 1455 RPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDP-EAVRGALRE 1513
Query: 498 LNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK 557
+L+ ++++L+ + AL RQL ++ E + + ++ ++ +AE E
Sbjct: 1514 FLQELRSAQRERDELRTQTS-------ALNRQLAEMEAERDSATSRARQLQKAVAESEEA 1566
Query: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAES 617
LS V+ EL L+ E+ + E+E+ A LD++A +
Sbjct: 1567 RRSVDGRLSGVQ-------------AELALQEES--------VRRSERERRATLDQVA-T 1604
Query: 618 QEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQK 677
E L+ ++L S +E++SK+K + + +++G + + +
Sbjct: 1605 LERSLQATESELRAS-QEKISKMKAN--------------------ETKLEGDKRRLKEV 1643
Query: 678 IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE 737
++ + L ++ L E+ + + L S ++++ + +++ LQ+++ E +
Sbjct: 1644 LDASESRTVKLELQRRSLEGELQRSR-LGLSDREAQAQALQDRVDSLQRQV---ADSEVK 1699
Query: 738 KGTLEQEVQELQ---LKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI- 793
GTL+ V+ L K E E +++K L E AQ A + +D+ L+ L
Sbjct: 1700 AGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTAC 1759
Query: 794 -HTPVSQEERLIFLDSIKSKSK--DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTF 850
H +ERL S+++ S ++++ L E DL+ Q ++ ++++ R
Sbjct: 1760 EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL 1819
Query: 851 SFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTV 910
++ QE A L L+D + + +L +L L V
Sbjct: 1820 -----------RQRQEGEAAALNTVQKLQDERRL----LQERLGSLQRALAQLEAEKREV 1864
Query: 911 KMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKH 970
+ + ++D+ + TL+ VE++ E EK L + L+ +L +
Sbjct: 1865 ERSALRLEKDRVALRRTLDK---VEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921
Query: 971 GEISFLNEEVKSLKQEKE----QVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTM 1026
+I L +V L+Q +V + ++LE+ R + Q+ + +
Sbjct: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
Query: 1027 TSRGAEGSVSKVNKSFGEE 1045
RG E VS + +E
Sbjct: 1982 RVRGLEEQVSTLKGQLQQE 2000
Score = 72.8 bits (177), Expect = 6e-12
Identities = 97/474 (20%), Positives = 201/474 (42%), Gaps = 54/474 (11%)
Query: 3110 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA 3169
+E S + ++ L Q+ EM+ E S RA +LQ+ ++ + + L+
Sbjct: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS 1575
Query: 3170 QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA 3229
+ EL ++ + +E A D+V L +L + + + R Q + K KA
Sbjct: 1576 GVQAELALQEESVRRSERERRA-------TLDQVATLERSLQATESELRASQEKISKMKA 1628
Query: 3230 KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLS 3289
+ E DK L+++ L++ + R ++L L + L S+ + + +AQ
Sbjct: 1629 NETKLEG-DKRRLKEV---LDASESRTVKLELQRRSLEGELQRSRLGLSDR----EAQAQ 1680
Query: 3290 EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQ 3349
Q R LQ + +V+ + T++R A+++ S+G L++
Sbjct: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA------------LRDKV 1728
Query: 3350 KQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ 3409
+ L E ++ LN T L + E DRQV ++ L ++A +E +K+ L
Sbjct: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLG 1788
Query: 3410 SKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELER----EEKRESRRILYQNLN 3465
+V+ L+ ++ + Q + + + Q+L+ ++++ Q+ E ++ ++ RR+L + L
Sbjct: 1789 EQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLG 1848
Query: 3466 ----------------EPTTWSLTSDRTRNWVLQQKIEGETKESN------YAKLIEMNG 3503
E + L DR K+E E S+ A+ ++
Sbjct: 1849 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDR 1908
Query: 3504 GGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEI 3557
TG EL ++++Q + +++ VL Q S Q E + + +Q+ ++ +
Sbjct: 1909 TLTGAELELAEAQRQIQQLEAQVVVLEQSHSP-AQLEVDAQQQQLELQQEVERL 1961
Score = 60.1 bits (144), Expect = 4e-08
Identities = 87/498 (17%), Positives = 210/498 (42%), Gaps = 39/498 (7%)
Query: 5 ERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQC-- 62
ER + A Q + +A+ D + +Q +K S + S L+ Q++
Sbjct: 1524 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELAL 1583
Query: 63 -NEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
E S + +T+ +T+ R+L + T E S E S++ +
Sbjct: 1584 QEESVRRSERERRATLDQVATLERSLQA---TESELRASQEKISKMKANETKLEGDKRRL 1640
Query: 122 SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
V+ + + E + E Q S L E++ Q ++ L R++ +
Sbjct: 1641 KEVLDASESRTVKLE----LQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADS 1696
Query: 182 RVTYGTEGL--QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQ 239
V GT L ++L A +++ +G + L +A + ++ +++ LQ
Sbjct: 1697 EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNS---TRDKNLHLQ 1753
Query: 240 IQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQIS 299
+ + + L +A++Q + +Q++ + D + ++ + Q+
Sbjct: 1754 KALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQ 1813
Query: 300 FLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEE-----------LNTKIIEEEKKTLEL 348
L+E ++ + ++ + + +++Q++ +++E L + E E+ L L
Sbjct: 1814 QLREVLR--QRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRL 1871
Query: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLE-------LTNSKQKERQSSEEIKQLMGTV 401
+ + L +++ + ++ +++ + E LT ++ + ++ +I+QL V
Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV 1931
Query: 402 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQME 461
L++ +H +Q E D Q+ + E Q+++E+LR+ + ++ ++ ++ RQ + +E
Sbjct: 1932 VVLEQ-SHSPAQLEVD-AQQQQLELQQEVERLRSA--QAQTERTLEARERAHRQRVRGLE 1987
Query: 462 EMKTRHKGEMENALRSYS 479
E + KG+++ LR S
Sbjct: 1988 EQVSTLKGQLQQELRRSS 2005
Score = 33.1 bits (74), Expect = 5.6
Identities = 83/422 (19%), Positives = 175/422 (41%), Gaps = 61/422 (14%)
Query: 1254 ENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQT--DGMKLEFGEENLPKEETEFLSIHSQM 1311
+ + TL + ++L Q ++SK+ +T +G K +E L E+ + + Q
Sbjct: 1600 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRL-KEVLDASESRTVKLELQR 1658
Query: 1312 TNLEDIDVNHKSKLSSLQDLEKTKL-----EEQVQELESLISSLQQQLKETE-------- 1358
+LE +L++++L E Q Q L+ + SLQ+Q+ ++E
Sbjct: 1659 RSLEG-------------ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL 1705
Query: 1359 ---------QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTM----YPGSC 1405
E L+ +++ ++E+ S ++S Q+ + +
Sbjct: 1706 TVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQV 1765
Query: 1406 VKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465
+++ +D + E K+ +++ + ++ E + E+ +V + ++ R
Sbjct: 1766 LQERLDAARQALSE-ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE 1824
Query: 1466 GGKE--NTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGE 1523
G NT Q QE+ + L+Q + + E ++ +++ L + L +
Sbjct: 1825 GEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDK 1884
Query: 1524 HGKEILLSNSDPHDIPESK---DCVLTISEEMFSKDKTFIVRQSIHDEISV---SSMDAS 1577
+E L S+ D + K D LT +E ++ + I Q + ++ V S A
Sbjct: 1885 VEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQI--QQLEAQVVVLEQSHSPAQ 1942
Query: 1578 RQLMLNEEQLEDMRQEL--VRQYQEHQQATELLRQAHMRQMERQREDQ-----EQLQEEI 1630
++ ++QLE ++QE+ +R Q + T R+ RQ R E+Q QLQ+E+
Sbjct: 1943 LEVDAQQQQLE-LQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001
Query: 1631 KR 1632
+R
Sbjct: 2002 RR 2003
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 167 bits (422), Expect = 2e-40
Identities = 359/1713 (20%), Positives = 725/1713 (42%), Gaps = 282/1713 (16%)
Query: 173 ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELT 232
EL +E+EE+R TEG II LT L EK ET ++ L L
Sbjct: 50 ELEKEIEELRSKPVTEG-------------TGDIIKALTERLDALLLEKAETEQQCLSLK 96
Query: 233 EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE-QDHLLEDYQKKK 291
+++ K++ Q+++ S T H + +Q + + +++E ++ L+ K
Sbjct: 97 KENIKMK---QEVEDSVTKMGDAHK-------ELEQSHINYVKEIENLKNELMAVRSKYS 146
Query: 292 EDFTMQISFLQEKIKV-YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE--------E 342
ED L+E + E+ + K +N++++ +++ + IE++ E+ +
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
Query: 343 KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVE 402
T E K+ +T ++ E Q QKN I +++ EL K + EE+K+LM +E
Sbjct: 207 ATTDEKKETVTQLQNII-EANSQHYQKN--INSLQEELLQLKAIHQ---EEVKELMCQIE 260
Query: 403 ELQKRN----HKDSQFETDIVQRMEQETQRKLEQLRAELDEM-----YGQQIVQMKQELI 453
K + +K ++ + ++V++ E + ++ EL+ + Q Q+ L+
Sbjct: 261 ASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILL 320
Query: 454 RQH--MAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS---- 507
+++ + Q+ K +H + L S +I +D++ MN +L + Q
Sbjct: 321 QENTFVEQVVNEKVKHLEDTLKELESQHSIL--KDEVTYMNNLKLKLEMDAQHIKDEFFH 378
Query: 508 QKEKL----------KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE-- 555
++E L KEE G ++E+ L+ +L L ++ ++ EQ R Q++ EQ
Sbjct: 379 EREDLEFKINELLLAKEEQGCVIEK---LKSELAGLNKQFCYTVEQHNREVQSLKEQHQK 435
Query: 556 --SKLNEAHKSLSTVEDLKA--EIVSASESRKELELKHEAEVTNYKIKLEMLE------- 604
S+LNE S S E L EI E + L+ + + + NY+ E++E
Sbjct: 436 EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 495
Query: 605 -------KEKNAVLDRMAESQEAELERLRT-------------QLLFSHEEELSKLKEDL 644
+E ++ + A ++LRT +L +E+ LS+ +
Sbjct: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVP 555
Query: 645 EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITK------------- 691
E+E+ I + K+ + + Q D + E+ KI ++ EKD+ I K
Sbjct: 556 ELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK 615
Query: 692 ----QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747
+ +LILE+ K K Q NS+ E+ ++NEL +E + KEK +Q++++
Sbjct: 616 KCEREERLILELGK-KVEQTIQYNSELEQ---KVNELTGGLE---ETLKEKDQNDQKLEK 668
Query: 748 LQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD 807
L ++ ++L E + L + L EN+ L EKK L L++ +SQ+E +I +
Sbjct: 669 LMVQMKVL----SEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVF--LSQKEDVILKE 722
Query: 808 SIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEK---QRNTFSF------------ 852
I + EK++++++EE ++L + + NE+++K + + F
Sbjct: 723 HI------TQLEKKLQLMVEEQDNLNK--LLENEQVQKLFVKTQLYGFLKEMGSEVSEDS 774
Query: 853 AEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKM 912
EK+ Q + E A + + K +L ++++ LE + ++K L EE +Q ++
Sbjct: 775 EEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQ-----CEEL 829
Query: 913 KSSV--FDEDKTFVAETLE----MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQL 966
KS + ++++K + + LE E ++ D E+ E T+ E L ++ ++S+
Sbjct: 830 KSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC 889
Query: 967 KQ----KHGEISFLNEEVKSLKQEKEQVSLRCRELE-IIINHNRAENVQSCDTQVSSL-- 1019
+ E F+ E ++LK EQ LR R E I++ + A++ + +SS+
Sbjct: 890 SKSEIHNEKEKCFIKEH-ENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKE 948
Query: 1020 LDGVVTMTSRGAEGSVSKVNKSFGEESKIMVE-DKVSFENMTVGEESKQEQLILDHLPSV 1078
L+ + + + K+NK K E D E TV EE + + D L S
Sbjct: 949 LEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQL-SA 1007
Query: 1079 TKESSLRATQPSEN-----DKLQKELNVLKSEQN-------DLRLQMEAQRICLSLVYST 1126
+ ++ + +N +K ++L+V K N DL Q+ + + S
Sbjct: 1008 SMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSD 1067
Query: 1127 HVD---QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKP 1183
+ D ++ N K + L+ + A +K E +K+ Q E + + T +E +
Sbjct: 1068 NEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKL-QKEQKIKEHATTVNELEE 1126
Query: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE---NEDP 1240
L + + K +K + + +Q L V + L + D E +++ N++
Sbjct: 1127 LQVQLQKEKKQLQKT----MQELELVKKDAQQTTL-MNMEIADYERLMKELNQKLTNKNN 1181
Query: 1241 ELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKE 1300
+++D E++ ++ TL ++T + + + + +KI ++ L K
Sbjct: 1182 KIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKI-------------KQLLVKT 1228
Query: 1301 ETEFLSIHSQMTNLEDIDVNHKSKL-SSLQDLEKTKLEEQVQELESLISSLQQQLKETEQ 1359
+ E T+ + + K +L +S Q +E K+ Q+ E+ S + + LK + +
Sbjct: 1229 KKELADSKQAETDHLILQASLKGELEASQQQVEVYKI--QLAEITSEKHKIHEHLKTSAE 1286
Query: 1360 NYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419
++ + Q+R+ A+ E + + +T + + +K+ + ++ +
Sbjct: 1287 QHQRTLSAYQQRVTALQEEC--RAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAET 1344
Query: 1420 FGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTE---------------LSRI 1464
G K+E +++L Q + +L++ + +++S Q+E +S+
Sbjct: 1345 EGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKE 1404
Query: 1465 SGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFK----PLSKE 1520
+ +E S + + + + E SQ+++ +F +EE + L ++
Sbjct: 1405 AELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQ 1464
Query: 1521 LGEHGKEIL-LSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDE----------- 1568
L + ++ L N P S L E + D + ++ E
Sbjct: 1465 LSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTE 1524
Query: 1569 --ISVSSMDASRQLMLNEEQ---------LEDMRQELVRQYQEHQQATELLRQAHMRQME 1617
S S+ S + +LN + E ++ELV++ ++ + L +R+ E
Sbjct: 1525 SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHL-NGLLRETE 1583
Query: 1618 RQR----EDQEQLQEEIKRLNRQLAQRSSIDN----ENLV---------SERERVLLEEL 1660
E + L+ EI+RL R + S N +N++ SERER LL +
Sbjct: 1584 ATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERER-LLPVI 1642
Query: 1661 EALKQLSLAGREKLCCELRNSSTQTQNGNENQG 1693
+ QLS + KL + + +N + + G
Sbjct: 1643 NTMLQLSPEEKGKLAAVAQG---EEENASRSSG 1672
Score = 166 bits (419), Expect = 5e-40
Identities = 313/1523 (20%), Positives = 648/1523 (42%), Gaps = 201/1523 (13%)
Query: 1507 DVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIH 1566
++K K+E + ++G+ KE+ S+ + E+ L +S+DK + +Q
Sbjct: 99 NIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQL-- 156
Query: 1567 DEISVSSMDASRQLML---NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ 1623
+E + ++ S QL +E+ ++ +++E+ + ++ L++ + ++E
Sbjct: 157 EEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETV 216
Query: 1624 EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSST 1683
QLQ I+ N Q Q+ N+ S L EEL LK + ++L C++ S+
Sbjct: 217 TQLQNIIEA-NSQHYQK------NINS-----LQEELLQLKAIHQEEVKELMCQIEASAK 264
Query: 1684 QTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI-LSNERYALQKAN--NRLLKILLEVVK 1740
+ + E++E K+ E K E L N R A AN N++ ILL+
Sbjct: 265 EHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQ--- 321
Query: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEA--SVKSCVHEEHTRVTDESIPSY 1798
VE+ + V + D + +S S++ + E ++K + + + DE
Sbjct: 322 ENTFVEQVVNEKVKHLEDTLKELESQHSIL-KDEVTYMNNLKLKLEMDAQHIKDEFFHER 380
Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE------IDPENEELMLNISSRLQA 1852
+ N++ + + E+G + + ++S AG ++ N E+ ++ + Q
Sbjct: 381 EDLEFKINELLLAKE--EQGCVIEK--LKSELAGLNKQFCYTVEQHNREVQ-SLKEQHQK 435
Query: 1853 AVEKLLEAISETSSQLEHAKVTQTELMRESFRQ-KQEATESLKCQEELRERLHEESRARE 1911
+ +L E S + + + + + ++E +QE E++ E LRE + E
Sbjct: 436 EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIM-------E 488
Query: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971
L EL ++ G I FE Q++ + L+Q+L A L ++Q
Sbjct: 489 ILQTELGESAGKISQE------FESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQG 542
Query: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031
E E L Q+E + L+ T K ++EK V + RD + K+++ +
Sbjct: 543 ENEKLLSQQELVPE---------LENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLT 593
Query: 2032 EQVSRFIELEQEKNTELMDLR---------------------QQNQALEKQLEKMRKFLD 2070
E+ FI + + E+ + Q N LE+++ ++ L+
Sbjct: 594 EEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE 653
Query: 2071 EQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLL 2130
E E+D Q+++KL Q+KV+ + + E L+ +K ++ ++L
Sbjct: 654 ETL----KEKDQNDQKLEKLMVQMKVL----------SEDKEVLSAEVKSLYEENNKLSS 699
Query: 2131 SKEQLQRDIQERNEEIEK--LEFRVRELE---QALLVSADTFQKVEDRKHFGAVEAKPEL 2185
K+QL RD++ + E L+ + +LE Q ++ D K+ + + + K +L
Sbjct: 700 EKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQL 759
Query: 2186 SLEVQLQAERDAIDRKEKEITNL----EEQLEQFREELEN----KNEEVQQLHMQLEIQK 2237
++ + D +EK++ N+ E L + EE N ++E+V +L +++ +
Sbjct: 760 YGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQ 819
Query: 2238 KESTTRLQEL-------EQENKLFKDDMEKLG----------LAIK---ESDAMSTQDQH 2277
+ES + +EL EQE L + ++E++ L +K E + Q+
Sbjct: 820 EESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLL 879
Query: 2278 VLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE---LIRDLETQIECL 2334
+ + +Q + E+ ++ + K + LK + K + ++ L++D + +
Sbjct: 880 IQVEEVSQTCSKSEIH-NEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSV 938
Query: 2335 MSDQECVKRNREEEIEQLNEVIEKLQQELANI---GQKTSMNAHSLSEEADSLKHQLDVV 2391
+D + EE+IE L + ++ ++++ I K S +E ++K +L+ +
Sbjct: 939 KNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESL 998
Query: 2392 IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSV 2451
+EK L + + KN+L E + QL E +E + NS
Sbjct: 999 RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNST 1058
Query: 2452 NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAK 2511
+ + ++ D +L + + L+S + E ++++ E +L+ K
Sbjct: 1059 -LQCETINSDNEDLLARI--ETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115
Query: 2512 DLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFC 2571
+ T +++++Q Q Q E + LQK + L+ + ++ L++ + +Y +
Sbjct: 1116 EHATT--VNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNM----EIADYERLM 1169
Query: 2572 QD-NQTISSEPERTNIQNLNQ------LREDELGSDISALTLRISELESQVVEMHTSLIL 2624
++ NQ ++++ + I++L Q +++ L +I++L + + E + ++ L+
Sbjct: 1170 KELNQKLTNKNNK--IEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVK 1227
Query: 2625 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEV----------LKT 2674
K+ E+A+ E + L LQ L+G + +++ + Q E+ LKT
Sbjct: 1228 TKK--ELADSKQAETDH--LILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKT 1283
Query: 2675 TTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLS 2734
+ E H S + + AL+ E A KAE A+ + E + V+ N+ QK+ S
Sbjct: 1284 SAEQ-HQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYK----VRVHNVLKQQKNKS 1338
Query: 2735 QVRDHLAEAK---EKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSS 2791
+ AK E L +L + + ++Q+S+ L I +S+ Q++ +
Sbjct: 1339 MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNN-----LQINVSELQTLQSEHDTLLERH 1393
Query: 2792 NQTPQILV-KNAGIQ---INLQSE--CSSEEVTEIISQFTEKIEKMQELHAAEILDMESR 2845
N+ Q V K A ++ ++QSE E T+ +SQ T + E ++ ++ ++
Sbjct: 1394 NKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEE 1453
Query: 2846 HISETETLKRE-HYVAVQL--LKEECGTLKAV-----IQCLRSKEGSSIPEL-------A 2890
H ETL+++ + QL LK E T V ++ LR + + +P L
Sbjct: 1454 HRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE 1513
Query: 2891 HSDAYQTREICSSDSGSDWGQGI 2913
+ +T + S S S + Q +
Sbjct: 1514 EGEGMETTDTESVSSASTYTQSL 1536
Score = 162 bits (410), Expect = 6e-39
Identities = 298/1334 (22%), Positives = 554/1334 (41%), Gaps = 209/1334 (15%)
Query: 92 ITSHEQGFSVE-LESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGA 150
+ EQG +E L+SE++ C V + + L+E+ +E
Sbjct: 392 LAKEEQGCVIEKLKSELA------GLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFL 445
Query: 151 QDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQL----------------Q 194
DS + E+ G + + E L +E +E + Y E L+++ Q
Sbjct: 446 SDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNY--ESLREIMEILQTELGESAGKISQ 503
Query: 195 EFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNS 254
EFE+ +Q+ + +L L+ A EKD + L +++KL Q + + E +
Sbjct: 504 EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKN 563
Query: 255 THSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK 314
LL Q+ L+E + + ++K+DF ++ +
Sbjct: 564 LQEKNGVYLLSLSQR----DTMLKELEGKINSLTEEKDDFINKLK-----------NSHE 608
Query: 315 KVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK 374
+++N +K + + +E +I EL K+ + + EL+ K+ ++L G L+E + +K+Q
Sbjct: 609 EMDNFHK-KCEREERLILELGKKVEQTIQYNSELEQKV---NELTGGLEETLKEKDQ--N 662
Query: 375 NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLR 434
+ KLE + K +E+ L V+ L + N+K S + +QL
Sbjct: 663 DQKLEKLMVQMKVLSEDKEV--LSAEVKSLYEENNKLSS---------------EKKQLS 705
Query: 435 AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA 494
+L+ Q+ + ++++H+ Q+E+ E +N + N V + +K
Sbjct: 706 RDLEVFLSQK----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYG 761
Query: 495 -INELNIKLQDTNSQKEKLK------EELGLILEEKCALQRQLEDLVEELSFSREQIQRA 547
+ E+ ++ + + +K+ + E L I EEKC L Q ++ V EL
Sbjct: 762 FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLEL---------- 811
Query: 548 RQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEK 607
E+E K L+ E V E K L +E E + +LE ++ EK
Sbjct: 812 -----EKEIKC------------LQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEK 854
Query: 608 NAVLDRMAESQEA-ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ 666
A+ + E + A E RL Q L EE+S+ EI + EK K + H
Sbjct: 855 EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHN----EKEKCFIKEH---- 906
Query: 667 IDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQK 726
+ L+ + QK L ++ +LIL LKD + K++ ++ + EL++
Sbjct: 907 -ENLKPLLEQK---------ELRDRRAELIL----LKDSLAKSPSVKNDPLS-SVKELEE 951
Query: 727 EIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKT 786
+IE L +E KEK E+++ +++L +K++ + Q +LE+ L+ EK
Sbjct: 952 KIENLEKECKEK---EEKINKIKLVAVKAKKELDSSRKETQTVKEELES----LRSEKDQ 1004
Query: 787 LEDMLKIHTPVSQEERLIFLDSIK-------SKSKDSVWEKEIEILIEENEDLKQQCIQL 839
L ++ ++ + + L+ K K + + +E IE L + + QC +
Sbjct: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
Query: 840 ---NEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKAL 896
NE++ + T K EV E+Q A V +LE K ++E + K +
Sbjct: 1065 NSDNEDLLARIETLQSNAKLLEVQILEVQRAKA---MVDKELEAEKLQKEQKIKEHATTV 1121
Query: 897 N--EELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTE-LMEKLEVTKREKL 953
N EEL +Q ++K + +T++ E+V+KD + + +E+ E+L
Sbjct: 1122 NELEELQVQ-------------LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERL 1168
Query: 954 ELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCD 1013
+ +L+++L K+ +I L +E+K KQ++E + L+ + +N +
Sbjct: 1169 -----MKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQ 1223
Query: 1014 TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILD 1073
V + + S+ AE + S E + + +V + + E + ++ I +
Sbjct: 1224 LLVKTKKE---LADSKQAETDHLILQASLKGELEAS-QQQVEVYKIQLAEITSEKHKIHE 1279
Query: 1074 HL-PSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVR 1132
HL S + + LQ+E K+EQ + + E+ ++ + V ++
Sbjct: 1280 HLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSM 1339
Query: 1133 EYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQ 1192
E E K E LI + K+++ Q Q+ + ++T ++ + L LQ
Sbjct: 1340 SQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQS-EHDTLLERHNKMLQ 1398
Query: 1193 KAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDF 1252
+ VS+E + LCS+ E + +E + S+NE +R +V+
Sbjct: 1399 ETVSKEAE-LREKLCSIQSE------NMMMKSEHTQTVSQLTSQNEVLR-NSFRDQVRHL 1450
Query: 1253 QE----NMHTLLNKVTEEYNKLLVLQ---TRLSKIWGQQ----------TD----GMKLE 1291
QE + TL ++++ +L L+ T S + QQ TD M
Sbjct: 1451 QEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510
Query: 1292 FGEENLPKEETEFLSIHSQMT---NLEDIDVNHKSKLS-SLQDLEKTKLEEQVQELESLI 1347
EE E T+ S+ S T +LE + + ++KL L E TK EE VQ+L S
Sbjct: 1511 TREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTK-EELVQKLSSTT 1569
Query: 1348 SS---LQQQLKETE 1358
S L L+ETE
Sbjct: 1570 KSADHLNGLLRETE 1583
Score = 160 bits (406), Expect = 2e-38
Identities = 358/1793 (19%), Positives = 744/1793 (41%), Gaps = 246/1793 (13%)
Query: 203 RDGIITQLTANLQQARRE---KDETMREFLELTEQSQKLQIQFQQLQAS-ETLRNSTHSS 258
+DG+ + T +++ E K++ ++ + QK + + +L+ E LR+ +
Sbjct: 6 QDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTE 65
Query: 259 TAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVEN 318
D+++A + L LE+ + + KKE+ M+ K+ + K++E
Sbjct: 66 GTGDIIKALTERLD-ALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAH--KELEQ 122
Query: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL 378
S+ ++E E + EL + + L+ +L A EL EQ+ +N N+K
Sbjct: 123 SHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVK- 181
Query: 379 ELTNSKQKERQSSEE-----IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQL 433
+L +K R EE KQL T +E + +Q + +I++ Q Q+ + L
Sbjct: 182 KLQEEIEKIRPGFEEQILYLQKQLDATTDE---KKETVTQLQ-NIIEANSQHYQKNINSL 237
Query: 434 RAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV 493
+ EL Q+ + QE +++ M Q+E H+ E+ N L V + + N+
Sbjct: 238 QEEL-----LQLKAIHQEEVKELMCQIEASAKEHEAEI-NKLNELKENLVKQCEASEKNI 291
Query: 494 AINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAE 553
+ +L++ ++ + C++ Q VE++ E+++ T+ E
Sbjct: 292 Q-KKYECELENLRKATSNANQD-----NQICSILLQENTFVEQV--VNEKVKHLEDTLKE 343
Query: 554 QESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDR 613
ES+ + ++ + +LK ++ ++ K+ E HE E +KI +L KE+ +
Sbjct: 344 LESQHSILKDEVTYMNNLKLKLEMDAQHIKD-EFFHEREDLEFKINELLLAKEEQGCVIE 402
Query: 614 MAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDN-LGIHYKQQIDGLQN 672
+S+ A L + + H E+ LKE +H+ I +L + L K+++
Sbjct: 403 KLKSELAGLNKQFCYTVEQHNREVQSLKE----QHQKEISELNETFLSDSEKEKL----- 453
Query: 673 EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR 732
+ +I+ ++ + +NL ++ + IL L+++ + L E+ ++ +E E ++
Sbjct: 454 TLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEIL----QTELGESAGKISQEFESMK 509
Query: 733 QEEKEKGTLEQEVQELQ--LKTELLEKQ-MKEKENDLQEKFAQLEAENSILKDEKKTLED 789
Q++ +V ELQ L+T EK + E N LQ + +L ++ ++ + + T+++
Sbjct: 510 QQQ------ASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKN 563
Query: 790 MLKIHTPVSQEERLIFLDSIKSK-SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRN 848
+ QE+ ++L S+ + + E +I L EE +D + +EE++ N
Sbjct: 564 L--------QEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD---N 612
Query: 849 TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
E+ E EL ++ ++ +LE N+ + LK ++ + Q++
Sbjct: 613 FHKKCERE-ERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLK--EKDQNDQKLEKL 669
Query: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS-DLSEQLK 967
V+MK V EDK + + E+ + E++ EK ++++ ++ LSQ+ L E +
Sbjct: 670 MVQMK--VLSEDKEVL--SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHIT 725
Query: 968 QKHGEISFLNEEVKSLKQ--EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025
Q ++ + EE +L + E EQV + ++ + S D++ +++ +
Sbjct: 726 QLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQA 785
Query: 1026 MTSRGAEGSVSKVNKSFGEESKIMVEDK----VSFENMTVGEESKQEQLILDH-LPSVTK 1080
+ A+ + K N +F + K++ +K + E++ EE K L+ D+ V
Sbjct: 786 VGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELK--SLLRDYEQEKVLL 843
Query: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140
L Q SE + LQ +L +K+ RL+ + I + V T + + NEK+
Sbjct: 844 RKELEEIQ-SEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQT---CSKSEIHNEKE 899
Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200
K E L E+K ++ + L+ + + PL + +L++ +
Sbjct: 900 KCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS-SVKELEEKIEN--- 955
Query: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260
L+ C E V A+ + +S ++ EL+ R E +M L+
Sbjct: 956 --LEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI 1013
Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
N LL + + ++ ++ E E+L ++ + + E I+ +
Sbjct: 1014 QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQ------LRNSTLQCETINSD 1067
Query: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380
++ L+ ++ L+ +VQ LE +Q+ ++ EAE LQK + +T
Sbjct: 1068 NEDLLARIETLQSNAKLLEVQILE-----VQRAKAMVDKELEAE--KLQKEQKIKEHATT 1120
Query: 1381 PPSLPVDSVVI--TESDAQRTMYPGSCVKKNIDGTIEFSGEFG------------VKEET 1426
L V + + Q+TM VKK+ T + E + +
Sbjct: 1121 VNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKN 1180
Query: 1427 NIVKLLE------KQYQEQLEEEVAKVIVSMSIAFAQQTELSR-ISGGKENTASSKQA-- 1477
N ++ LE KQ QE L+EE+ + S+ + T++ + + K+ A SKQA
Sbjct: 1181 NKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAET 1240
Query: 1478 -HAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH 1536
H + Q E++ SQ Q+ + ++ ++ ++ EH L ++++ H
Sbjct: 1241 DHLILQASLK--GELEASQQQVEVYKIQLAEITSEKH------KIHEH----LKTSAEQH 1288
Query: 1537 D--IPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL 1594
+ + V + EE R + ++ +V+S S ++ ++
Sbjct: 1289 QRTLSAYQQRVTALQEE---------CRAAKAEQATVTSEFESYKVRVHNVL-------- 1331
Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIK----------RLNRQLAQRSSID 1644
QQ + + QA +++RE E L +++K ++N Q +
Sbjct: 1332 ------KQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSE 1385
Query: 1645 NENLVSERERVLLEELEALKQLSLAGREKLC------CELRNSSTQTQNGNENQGEVEEQ 1698
++ L+ ++L E + +L REKLC +++ TQT + +Q EV
Sbjct: 1386 HDTLLERHNKMLQETVSKEAEL----REKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRN 1441
Query: 1699 TFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILD 1758
+F+++ + E R ++ +L K+ ++ + L
Sbjct: 1442 SFRDQVRHLQEE---------HRKTVETLQQQLSKMEAQLFQ----------------LK 1476
Query: 1759 RSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEG 1818
++S S ++ S+K+ +T D+P D++ ++ EG
Sbjct: 1477 NEPTTRSPVS------SQQSLKNLRERRNT-------------DLPLLDMHTVTREEGEG 1517
Query: 1819 TELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV-------EKLLEAISETSSQLEHA 1871
E + S + + E+L+ + ++L+ + E+L++ +S T+ +H
Sbjct: 1518 METTD--TESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHL 1575
Query: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924
L+RE+ E +K + RL E ++ RE+ A L + V+
Sbjct: 1576 ----NGLLRETEATNAILMEQIKLLKSEIRRL-ERNQEREKSAANLEYLKNVL 1623
Score = 159 bits (401), Expect = 7e-38
Identities = 302/1582 (19%), Positives = 673/1582 (42%), Gaps = 170/1582 (10%)
Query: 2086 EIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145
E++K ++L+ P + + E+L L EK + + L K++ + QE +
Sbjct: 50 ELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDS 109
Query: 2146 IEKLEFRVRELEQALLVSADTFQKVED-----RKHFGAVEAKPELSLEVQLQAERDAIDR 2200
+ K+ +ELEQ+ + + +++ R + +A + LE + + + ++
Sbjct: 110 VTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQ 169
Query: 2201 ------KEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI---QKKESTTRLQEL-EQE 2250
E + L+E++E+ R E E++ L QL+ +KKE+ T+LQ + E
Sbjct: 170 LKFQNNSEDNVKKLQEEIEKIRPGFE---EQILYLQKQLDATTDEKKETVTQLQNIIEAN 226
Query: 2251 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2310
++ ++ ++ L + + A+ ++ L + +E E EI++LNE L +Q +
Sbjct: 227 SQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEA 286
Query: 2311 TTDN--KVIEEKNELIR------DLETQI-ECLMSDQECVKRNREEEIEQLNEVIEKLQQ 2361
+ N K E + E +R + + QI L+ + V++ E+++ L + +++L+
Sbjct: 287 SEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELES 346
Query: 2362 E----------LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEM-T 2410
+ + N+ K M+A + +E + L+ I E L +++ E++ +
Sbjct: 347 QHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKS 406
Query: 2411 FMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2470
+ + K+ + + Q +E+ SLK + + ++I + E ++ +K +L ++
Sbjct: 407 ELAGLNKQFCYTVEQHNREVQSLKEQHQ--KEISELNETFLS------DSEKEKLTLMFE 458
Query: 2471 EDALKSLENQTYFKSFEENGKGSIINLET-----RLLQLESTVSAKDLELTQCYKQIKDM 2525
LK ++ ++ + +I+N E+ +LQ E SA + ++ + M
Sbjct: 459 IQGLKE-----QCENLQQEKQEAILNYESLREIMEILQTELGESAGKIS-----QEFESM 508
Query: 2526 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE---AVQEYAKFCQDNQTISSEPE 2582
++Q + LQ+K+ E+ V+++Q E + + + TI + E
Sbjct: 509 KQQQASDVHELQQKLRTA--FTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQE 566
Query: 2583 RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKK 2642
+ + L+ + D + ++ +I+ L + + L E+++ K +E+
Sbjct: 567 KNGVYLLSLSQRDTMLKELEG---KINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERL 623
Query: 2643 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE-SGFFNELEALRAESVAT 2701
+LEL K +E + E E+K + + +T E ++++ +++ L +
Sbjct: 624 ILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVL 683
Query: 2702 KAELASYKEKAEKLQEEL--LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET--E 2757
AE+ S E+ KL E L ++ + QK+ +++H+ + ++KL ++ +E + +
Sbjct: 684 SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNK 743
Query: 2758 VQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEV 2817
+ E+++ + L +K +Q G LK S + K+ + E ++
Sbjct: 744 LLENEQV---QKLFVK------TQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKIN 794
Query: 2818 TEIISQFTEKIEKMQELHAAEILDMESRHISETETLK---REHYVAVQLLKEECGTLKAV 2874
E + ++ EK+ EL EI ++ + + E LK R++ LL++E +++
Sbjct: 795 EEKCNLAFQRDEKVLELEK-EIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853
Query: 2875 IQCLRS-----KEGSSIPELAHSDAY----QTREICSSDSGSDWGQGIYLTHSQGFDIAS 2925
+ L+S K + L + + + + CS + + ++ +
Sbjct: 854 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
Query: 2926 EGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERK 2985
E + A K +V N+ + + E + E +E++
Sbjct: 914 EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC---------KEKE 964
Query: 2986 AYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF--LEERSVLLA 3043
IN I + K E + ES + +L +++ + E LL
Sbjct: 965 EKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLL 1024
Query: 3044 AFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQ-AAMECLQ-KADRRSLLSEIQALHAQM 3101
+ + L N E RI++ + + + ++C +D LL+ I+ L +
Sbjct: 1025 EYEKQSEQLDVEKERA--NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNA 1082
Query: 3102 NGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV 3161
++ + Q ++ + LE QK+ ++ E ++ ++ ELQ QL EK
Sbjct: 1083 KLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELE----ELQVQLQKEK--- 1135
Query: 3162 AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQ 3221
+L +T ELE K ++ +E+ D + LN L ++ K +L+
Sbjct: 1136 ----KQLQKTMQELELV----KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187
Query: 3222 WALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQR 3281
++ +K K +E +EE+ L+ S++ +++N ++ LL + K+ L +S+Q E+
Sbjct: 1188 QEIKIQKQK----QETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQA-ETDH 1242
Query: 3282 MLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS 3341
++ A L E + Q +E K+++ E++S + ++H L++S Q R
Sbjct: 1243 LILQASLKGELEAS---QQQVEVYKIQLAEITS---EKHKIHEHLKTSAEQHQ-RTLSAY 1295
Query: 3342 EDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG 3401
+ + LQ++ + + +E E YK+ +Q +K++ + + + ++
Sbjct: 1296 QQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQ-QKNKSMSQAETEGAKQEREHL 1354
Query: 3402 QKKMHELQSKVEDLQRQLEEKRQQVYKLDLEG----QRLQGIMQEFQKQELEREEKR--- 3454
+ + +L+ K++D Q L+ ++ L E +R ++QE +E E EK
Sbjct: 1355 EMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSI 1414
Query: 3455 ESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETK--ESNYAKLIEMNGGGTGCNHEL 3512
+S ++ ++ + T LTS +N VL+ + + + + K +E
Sbjct: 1415 QSENMMMKSEHTQTVSQLTS---QNEVLRNSFRDQVRHLQEEHRKTVET----------- 1460
Query: 3513 EMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE-- 3570
++Q+L + ++L L + + R + + + N D +L + +T ++GE
Sbjct: 1461 --LQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGM 1518
Query: 3571 ----EPSLVSPSTSCGSLTERL 3588
S+ S ST SL + L
Sbjct: 1519 ETTDTESVSSASTYTQSLEQLL 1540
Score = 158 bits (400), Expect = 9e-38
Identities = 329/1701 (19%), Positives = 701/1701 (41%), Gaps = 273/1701 (16%)
Query: 1139 KDKALCSLKEELIFAQEEKIK--ELQK-IHQLELQTMKTQETGDEGKPLHLLIGKL--QK 1193
K+ + K++++ Q+ K + EL+K I +L + + T+ TGD K L + L +K
Sbjct: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPV-TEGTGDIIKALTERLDALLLEK 85
Query: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENS-GDYISENEDPELQDYRYEVQDF 1252
A +E+ L+ +K + ED GD E E + +Y E+++
Sbjct: 86 AETEQQCLSLKK----------ENIKMKQEVEDSVTKMGDAHKELEQSHI-NYVKEIENL 134
Query: 1253 QENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTD-GMKLEF---GEENLPKEETEFLSIH 1308
+ + + +K +E+ L Q +L + Q + +L+F E+N+ K + E
Sbjct: 135 KNELMAVRSKYSEDKANL---QKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEE----- 186
Query: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCL 1368
+E I + ++ LQ +L+ E + ++ LQ ++ Q+Y+ I+ L
Sbjct: 187 -----IEKIRPGFEEQILYLQK----QLDATTDEKKETVTQLQNIIEANSQHYQKNINSL 237
Query: 1369 QK---RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGE-FGVKE 1424
Q+ +L+A+ + V + E +A+ + +K+N+ E S + K
Sbjct: 238 QEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKL--NELKENLVKQCEASEKNIQKKY 295
Query: 1425 ETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQE 1484
E + L + + ++ +++ + F +Q ++ ++ + H++ + E
Sbjct: 296 ECELENLRKATSNANQDNQICSILLQEN-TFVEQVVNEKVKHLEDTLKELESQHSILKDE 354
Query: 1485 QHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDC 1544
Y N +KL E K+EF ++L E+LL+ E + C
Sbjct: 355 VTYMNNLKLK--------LEMDAQHIKDEFFHEREDLEFKINELLLAK-------EEQGC 399
Query: 1545 VLT-ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE------------------- 1584
V+ + E+ +K F H+ V S+ Q ++E
Sbjct: 400 VIEKLKSELAGLNKQFCYTVEQHNR-EVQSLKEQHQKEISELNETFLSDSEKEKLTLMFE 458
Query: 1585 --------EQLEDMRQELVRQYQEHQQATELLR-----------QAHMRQMERQREDQEQ 1625
E L+ +QE + Y+ ++ E+L+ Q ++Q D +
Sbjct: 459 IQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHE 518
Query: 1626 LQEEI------KRLNRQLAQRSSIDNENLVSERERVL--------LEELEALKQLSLAGR 1671
LQ+++ K + R +NE L+S++E V L+E + LSL+ R
Sbjct: 519 LQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQR 578
Query: 1672 EKLCCELR---NSSTQTQNG--NENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK 1726
+ + EL NS T+ ++ N+ + EE K+ +R+ E + E+ +Q
Sbjct: 579 DTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE-ERLILELGKKVEQTIQY 637
Query: 1727 ANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE 1786
N+ L + +V + T +EET+ ++ Q L+ + + + K + E
Sbjct: 638 -NSELEQ---KVNELTGGLEETLK-------EKDQNDQKLEKLMVQMKVLSEDKEVLSAE 686
Query: 1787 HTRVTDESIPSYSGSDMPRNDINMWSKVTEEG------TELSQRLVRSGFAGTEIDP--E 1838
+ +E+ S D+ ++ E+ T+L ++L ++ E
Sbjct: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746
Query: 1839 NEELM-LNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ- 1896
NE++ L + ++L ++++ +SE S + + V Q + ES + E +L Q
Sbjct: 747 NEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQA--VGESLAKINEEKCNLAFQR 804
Query: 1897 -EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
E++ E E +E+ V+ + + ++ Y EK L ++++E + L+ +LL
Sbjct: 805 DEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEM 864
Query: 1956 SNRLQELEAEQQ----QIQEERELLSRQKEAMKAEAGPVEQQ-----LLQETEK------ 2000
N ++ E Q Q++E + S+ + + E +++ LL++ E
Sbjct: 865 KNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAE 924
Query: 2001 --LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNT----------EL 2048
L+K+ L ++ V++D VK LE +E E E++ N EL
Sbjct: 925 LILLKDSL---AKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKEL 981
Query: 2049 MDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQ---------EIQKLEQQLKVVPR 2099
R++ Q ++++LE +R D+ + RD+ Q E +K +QL V
Sbjct: 982 DSSRKETQTVKEELESLRSEKDQLSASM---RDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038
Query: 2100 FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA 2159
EH+ +E L L+ T +C + E L I+ + LE ++ E+++A
Sbjct: 1039 RANNFEHR---IEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRA 1095
Query: 2160 LLV-----SADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKE---------- 2204
+ A+ QK + K + E L+VQLQ E+ + + +E
Sbjct: 1096 KAMVDKELEAEKLQKEQKIKEHATTVNELE-ELQVQLQKEKKQLQKTMQELELVKKDAQQ 1154
Query: 2205 -------ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT----------RLQEL 2247
I + E +++ ++L NKN +++ L +++IQK++ T +Q+
Sbjct: 1155 TTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQY 1214
Query: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQD---QHVLFGKFAQIIQEKEV---EIDQLNEQV 2301
E++N K + K + +S T Q L G+ Q+ EV ++ ++ +
Sbjct: 1215 EEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEK 1274
Query: 2302 TKLQQQLKITTD--NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2359
K+ + LK + + + + + + L+ + ++Q V E +++ V++
Sbjct: 1275 HKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLK-- 1332
Query: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET 2419
QQ+ ++ Q + A E + L QL + + + + ++ E+ +++
Sbjct: 1333 QQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDS---QNNLQINVSELQTLQSEHDTL 1389
Query: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDH---LSKDKPELEVVLT--EDAL 2474
+ N++ QE ++ +E E EK+ SI ++ + +H +S+ + EV+ D +
Sbjct: 1390 LERHNKMLQE--TVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV 1447
Query: 2475 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETE 2534
+ L+ + + E + + +E +L QL++ + + +Q + +K+++E+ +
Sbjct: 1448 RHLQEE--HRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ--QSLKNLRERRNTDLP 1503
Query: 2535 MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL--NQL 2592
+L V ++ + E+V + + Q + + + PE L +
Sbjct: 1504 LLDMHTVTREE-------GEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEF 1556
Query: 2593 REDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG 2652
++EL +S+ T L + E + + EQ+++ + +
Sbjct: 1557 TKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEI---------------- 1600
Query: 2653 NEKKQREKEKKRSPQDVEVLK 2673
+ +R +E+++S ++E LK
Sbjct: 1601 -RRLERNQEREKSAANLEYLK 1620
Score = 147 bits (371), Expect = 2e-34
Identities = 285/1401 (20%), Positives = 571/1401 (40%), Gaps = 256/1401 (18%)
Query: 134 LREEEFGVDDSYSEQGAQDSPTHLEMMESELA---------GKQHEIEELNRELEEMRVT 184
L+ E V YSE A E M ++L + +++L E+E++R
Sbjct: 134 LKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPG 193
Query: 185 YGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQ 244
+ + L ++ +A ++ +TQL N+ +A SQ Q
Sbjct: 194 FEEQILYLQKQLDATTDEKKETVTQL-QNIIEA----------------NSQHYQKNINS 236
Query: 245 LQASETLRNSTHSSTAADLL-QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQE 303
LQ + H +L+ Q + H+ ++ + + L E+ K+ E I
Sbjct: 237 LQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQ---- 292
Query: 304 KIKVYEMEQD---KKVENSNKEE-----IQEKETIIEELNTKIIEEEKKTLELKDKLTTA 355
K YE E + K N+N++ + ++ T +E+ ++ E+ K LE D L
Sbjct: 293 --KKYECELENLRKATSNANQDNQICSILLQENTFVEQ----VVNEKVKHLE--DTLKEL 344
Query: 356 DKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE 415
+ L++++ N N+KL+L ++ IK E +R +D +F+
Sbjct: 345 ESQHSILKDEVTYMN----NLKLKL-------EMDAQHIKD-----EFFHER--EDLEFK 386
Query: 416 TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL 475
+ + ++E +E+L++EL + Q + QH +++ +K +H+ E+
Sbjct: 387 INELLLAKEEQGCVIEKLKSELAGLNKQFCY-----TVEQHNREVQSLKEQHQKEISELN 441
Query: 476 RSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE 535
++ + + ++++ LM ++Q Q E L++E + +L+ +E L
Sbjct: 442 ETFLSDS-EKEKLTLM--------FEIQGLKEQCENLQQEKQEAILNYESLREIMEILQT 492
Query: 536 ELSFSREQIQRARQTIAEQES----KLNEAHKSLSTVEDLKAEIVSASESRKELELKHEA 591
EL S +I + +++ +Q++ +L + ++ T +D E V+ + E L +
Sbjct: 493 ELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQE 552
Query: 592 EVTNYKIKLEMLEKEKNAVL-------DRMAESQEAELERLRTQ------LLFSHEEELS 638
V + ++ L+ EKN V D M + E ++ L + L + EE+
Sbjct: 553 LVPELENTIKNLQ-EKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD 611
Query: 639 KLKEDLEIEHRINIE-KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
+ E E R+ +E K I Y +++ NE++ +E EKD K +L++
Sbjct: 612 NFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV 671
Query: 698 EISKL-----------------------------KDLQQSLVNSKSEEMTLQINELQKEI 728
++ L +DL+ L + + I +L+K++
Sbjct: 672 QMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKL 731
Query: 729 EILRQEEKEKGTL--EQEVQELQLKTEL---LEKQMKEKENDLQEK------------FA 771
+++ +E+ L ++VQ+L +KT+L L++ E D +EK A
Sbjct: 732 QLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLA 791
Query: 772 QLEAE--NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE-----KEIEI 824
++ E N + ++K LE L+ QEE ++ + +KS +D E KE+E
Sbjct: 792 KINEEKCNLAFQRDEKVLE--LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEE 849
Query: 825 LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884
+ E E L+ +++ EK R +N + +E+ + + K ++ + K K
Sbjct: 850 IQSEKEALQSDLLEMKNANEKTR----LENQNLLIQVEEVSQTCS-----KSEIHNEKEK 900
Query: 885 QELEYKSKLKALNEELHLQRINPTTVKMKS------SVFDEDKTFVAETLEMGEVVEKDT 938
++ LK L E+ L+ + +K SV ++ + V E E E +EK+
Sbjct: 901 CFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC 960
Query: 939 TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL- 997
E EK+ K ++ ++L E + EE++SL+ EK+Q+S R+L
Sbjct: 961 KEKEEKINKIKLVAVK-------AKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI 1013
Query: 998 ------------------EIIINHNRAENVQ---------------SCDTQVSSLLDGVV 1024
++ + RA N + C+T S D +
Sbjct: 1014 QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA 1073
Query: 1025 TMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084
+ + + + +V + +K MV+ ++ E + ++EQ I +H +V + L
Sbjct: 1074 RIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKL------QKEQKIKEHATTVNELEEL 1127
Query: 1085 RATQPSENDKLQKELN----VLKSEQNDLRLQMEA---QRICLSLVY-----STHVDQVR 1132
+ E +LQK + V K Q + ME +R+ L + ++ +
Sbjct: 1128 QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187
Query: 1133 EYMENEKDKALCSLKEELIFAQ---EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI- 1188
+ ++ +K K +L+EE+ Q ++ ++ KI QL ++T K + + HL++
Sbjct: 1188 QEIKIQKQKQE-TLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQ 1246
Query: 1189 ----GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQD 1244
G+L+ + + Y +Q L + E + + +AE + + L
Sbjct: 1247 ASLKGELEASQQQVEVYKIQ-LAEITSEKHKIHEHLKTSAEQHQRT-----------LSA 1294
Query: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF 1304
Y+ V QE + ++ + R+ + QQ + + E K+E E
Sbjct: 1295 YQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKN-KSMSQAETEGAKQEREH 1353
Query: 1305 LS--IHSQMTNLEDIDVNHKSKLSSLQDLEK---TKLEEQVQELESLISSLQQQLKETEQ 1359
L I L+D N + +S LQ L+ T LE + L+ +S + +L+E
Sbjct: 1354 LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSK-EAELREKLC 1412
Query: 1360 NYEAEIHCLQ-KRLQAVSEST 1379
+ ++E ++ + Q VS+ T
Sbjct: 1413 SIQSENMMMKSEHTQTVSQLT 1433
Score = 145 bits (365), Expect = 1e-33
Identities = 328/1609 (20%), Positives = 682/1609 (42%), Gaps = 222/1609 (13%)
Query: 2179 VEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE--LENKNEEVQQLHMQLE-- 2234
+E P+ L + + I + + T LE+++E+ R + E + ++ L +L+
Sbjct: 22 LETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDAL 81
Query: 2235 -IQKKESTTRLQELEQENKLFKDDME----KLGLAIKESDAMSTQDQHVLFGKFAQIIQE 2289
++K E+ + L++EN K ++E K+G A KE + H+ + K
Sbjct: 82 LLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKE-----LEQSHINYVK------- 129
Query: 2290 KEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLE----TQIECLMSDQECVKRNR 2345
EI+ L ++ ++ +K E+K L + LE TQ+E +S+Q + N
Sbjct: 130 ---EIENLKNELMAVR--------SKYSEDKANLQKQLEEAMNTQLE--LSEQLKFQNNS 176
Query: 2346 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2405
E+ +++L E IEK++ E+ L+ QLD EK Q++
Sbjct: 177 EDNVKKLQEEIEKIRP--------------GFEEQILYLQKQLDATTDEKKETVTQLQNI 222
Query: 2406 NEEMT--FMKNVLKETNFKMNQLTQELFSLKR-ERESVEKIQSIPENSVNVAIDHLSKDK 2462
E + + KN+ N L +EL LK +E V+++ E S A +H
Sbjct: 223 IEANSQHYQKNI--------NSLQEELLQLKAIHQEEVKELMCQIEAS---AKEH----- 266
Query: 2463 PELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI 2522
E E+ + ++L Q E + K E L L S + + C
Sbjct: 267 -EAEINKLNELKENLVKQC-----EASEKNIQKKYECELENLRKATSNANQDNQIC---- 316
Query: 2523 KDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYA-KFCQDNQTISSE- 2580
+ ++ F +++ +K+ +L+ ++E + + + ++ + K D Q I E
Sbjct: 317 SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF 376
Query: 2581 -PERTNIQ-NLNQL--REDELGSDISALTLRISELESQ---VVEMHT---SLILEKEQVE 2630
ER +++ +N+L ++E G I L ++ L Q VE H + E+ Q E
Sbjct: 377 FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE 436
Query: 2631 IAEKNVL-----EKEKKLL--ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSN- 2682
I+E N EKEK L E+Q L E E Q+EK++ + + E L+ E+ +
Sbjct: 437 ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQE--AILNYESLREIMEILQTEL 494
Query: 2683 -EESGFFN-ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHL 2740
E +G + E E+++ + + EL A ++ LL + + L ++ +
Sbjct: 495 GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV 554
Query: 2741 AEAKEKLSILEKEDETEVQE-SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILV 2799
E + + L++++ + S++ M + L K++ + D K+ +S++
Sbjct: 555 PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614
Query: 2800 KNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAA--EILDMESRHISETETLKREH 2857
K + L E ++V + I +E +K+ EL E L + ++ + E L
Sbjct: 615 KKCEREERLILELG-KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLM--- 670
Query: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTH 2917
V +++L E+ L A ++ L Y+ SS+ + + +
Sbjct: 671 -VQMKVLSEDKEVLSAEVKSL----------------YEENNKLSSEK-KQLSRDLEVFL 712
Query: 2918 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS 2977
SQ D+ + + E ++ L + + NE +Q L + Y ++ +VS
Sbjct: 713 SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMG-SEVS 771
Query: 2978 EPWLEERKAYINTISSLKDLITKMQ-------LQREAEVYDSSQSHESFSDW---RGELL 3027
E E K +N + ++ + + K+ QR+ +V + + + + + E L
Sbjct: 772 ED--SEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEEL 829
Query: 3028 LALQQVFLEERSVL---LAAFRTELTALGTTDAVGLLNCLEQ-RIQEQGVEYQAAMECLQ 3083
+L + + +E+ +L L ++E AL +D + + N E+ R++ Q + Q E Q
Sbjct: 830 KSLLRDYEQEKVLLRKELEEIQSEKEAL-QSDLLEMKNANEKTRLENQNLLIQVE-EVSQ 887
Query: 3084 KADRRSLLSEIQA--LHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS-------QML 3134
+ + +E + + N + + ++E + LL+ ++ + S +
Sbjct: 888 TCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVK 947
Query: 3135 EMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3194
E++ ++ +++ E +E+++ K+V + K EL ++ E +T + E +
Sbjct: 948 ELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSA 1007
Query: 3195 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3254
++D + L +K+S +L +EKE+A + +EDL L +
Sbjct: 1008 SMRDLIQGAESYKNLLLEYEKQSEQLD--VEKERAN------NFEHRIEDLTRQLRNS-- 1057
Query: 3255 RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV----RIR 3310
LQ + + LL + ++S L + Q+ E Q + LE+EK+ +I+
Sbjct: 1058 -TLQCETINSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115
Query: 3311 EMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLE------EKHSRIVELLN 3364
E ++T++ EL QLQ Q + + +L+K+ +Q + R+++ LN
Sbjct: 1116 EHATTVNELEELQVQLQKEKK--QLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELN 1173
Query: 3365 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL----QRQLE 3420
+ K + ++ +Q K ++ ++TLQ E + ++ E +K++ L +++L
Sbjct: 1174 QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233
Query: 3421 EKRQQ-----VYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSD 3475
+ +Q + + L+G+ L+ Q+ + +++ E + ++++L T +
Sbjct: 1234 DSKQAETDHLILQASLKGE-LEASQQQVEVYKIQLAEITSEKHKIHEHLK---TSAEQHQ 1289
Query: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM---IRQKLQCVASKLQVLPQK 3532
RT + QQ++ +E AK + ++++ + ++Q+ S+ + K
Sbjct: 1290 RTLS-AYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAK 1348
Query: 3533 ASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQN 3592
ER E D+ I +Q++ + + + + +L Q E +L+ + + + +
Sbjct: 1349 -QEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK---MLQETVSKE 1404
Query: 3593 AELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEK 3652
AEL + + E NM+MK E + QT + + + N + + +
Sbjct: 1405 AELREKLCSIQSE-----NMMMKSE-----HTQTVSQLTSQNEVLRN---SFRDQVRHLQ 1451
Query: 3653 EVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRI 3701
E + TLQ+ L + EA++++LK E T SP S +LK +
Sbjct: 1452 EEHRKTVETLQQQLSKMEAQLFQLKNE------PTTRSPVSSQQSLKNL 1494
Score = 37.4 bits (85), Expect = 0.29
Identities = 79/396 (19%), Positives = 163/396 (41%), Gaps = 63/396 (15%)
Query: 3328 SSDGTGQSR-PPLPSEDLLKELQKQ---LEEKHSRIVELLNETEKYKLDSLQ------TR 3377
++ GTG+S+ LP EDL+K +KQ +++ SR EL E E+ + + +
Sbjct: 13 ATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIK 72
Query: 3378 QQMEKDRQVHRKTLQTEQEA------NTEGQKKMHELQSKVEDLQRQLEEKR-QQVYKLD 3430
E+ + + +TEQ+ N + ++++ + +K+ D ++LE+ V +++
Sbjct: 73 ALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIE 132
Query: 3431 LEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGET 3490
L + ++ + + +++ E L+E Q K + +
Sbjct: 133 NLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSE----------------QLKFQNNS 176
Query: 3491 KESNYAKLIEMNGGGTGCNHELEMIR----QKLQCVASKLQVLPQKASERL-QFETADDE 3545
E N KL E E+E IR +++ + +L + E + Q + +
Sbjct: 177 -EDNVKKLQE----------EIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEA 225
Query: 3546 DFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEE 3605
+ Q+NI+ + +L +L EE L ++ E I++L E
Sbjct: 226 NSQHYQKNINSLQEELLQLKAIHQEEVK---------ELMCQIEASAKEHEAEINKLNEL 276
Query: 3606 KNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASE----KEVWNREKLT 3661
K +L E+ I+ + + + N I +I+ E ++V N +
Sbjct: 277 KENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336
Query: 3662 LQKSLKRAEAEVYKLKAELR-NDSLLQTLSPDSEHV 3696
L+ +LK E++ LK E+ ++L L D++H+
Sbjct: 337 LEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHI 372
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 167 bits (422), Expect = 2e-40
Identities = 264/1279 (20%), Positives = 560/1279 (43%), Gaps = 194/1279 (15%)
Query: 183 VTYGTEGLQQLQEFEAAIKQRDGI---ITQLTANLQQARREKDETMREFLELTEQSQKLQ 239
VT+ E + LQ E ++ I + + +L++ E+DE +EL+E+ L
Sbjct: 163 VTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH 222
Query: 240 IQFQQLQASET-------LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE 292
++++ R + + +L AK +I +Q+LEE+ L D +++ E
Sbjct: 223 FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282
Query: 293 DFTMQISFLQEK----------IKVYEMEQDK------KVENSNKEEIQEKETI------ 330
+++ LQ++ ++Y E D +V+ E + KE +
Sbjct: 283 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY 342
Query: 331 ---IEEL--NTKIIEEEKKTLE--LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383
+EEL + +++ E K LE L+ +DK L EL+++ +Q ++ +M++E
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDK-LHELEKENLQLKAKLHDMEME---- 397
Query: 384 KQKERQSSEEIKQLMGTVEELQKRNHKDS---QFETDIVQRMEQETQRKLEQLRAELDEM 440
+ +R+ EE+ + T+E QK++ +S +E + + R + ++ + L E++E+
Sbjct: 398 RDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457
Query: 441 YGQQIVQMKQELIRQHMAQ-MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499
++++++ E Q + + +EE++T NA + N+ K + + NE+
Sbjct: 458 TSSRLLKLEME--NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515
Query: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559
+ Q + + K+ +++EK L++ +E L RE +R + + ++ LN
Sbjct: 516 QEKQSLQNCQNLSKD----LMKEKAQLEKTIETL-------RENSERQIKILEQENEHLN 564
Query: 560 EAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM----- 614
+ SL + AE + KE ++ HE+ + KL +E EK + +
Sbjct: 565 QTVSSLRQRSQISAE-ARVKDIEKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 615 ----AESQEAELERL--RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
AE E EL L +LL L E +E + N E ++N + K+ +D
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL--KKTLD 680
Query: 669 GLQNEMSQ----KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
+N Q + E Q +++NL ++N L+ + +K Q L N +E+ + +L
Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN---KELESEKEQL 737
Query: 725 QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
+K +E+L+ K+ LE Q L ++ + L+K ++ +Q QLE+E L+ E
Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMEN 793
Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844
+TL+ K+ + + K +E L +EN+ L+Q+ QL ++
Sbjct: 794 QTLQ---------------------KNLEELKISSKRLEQLEKENKSLEQETSQLEKD-- 830
Query: 845 KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQR 904
+K E + L+++ ++KD + N + + + K L++E+ + +
Sbjct: 831 ---------KKQLEKENKRLRQQ----AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877
Query: 905 INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE 964
+ V++K +EK+ EL+++ + + + L + L +SE
Sbjct: 878 --ESCVRLKE-------------------LEKENKELVKRATIDIKTLVTLREDL--VSE 914
Query: 965 QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV 1024
+LK + +N +++ L E E++ L +E + + + + ++++ S L +
Sbjct: 915 KLKTQQ-----MNNDLEKLTHELEKIGLN-KERLLHDEQSTDDRYKLLESKLESTLKKSL 968
Query: 1025 TMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084
+ +++ +S ++ E K +N ++ + E+ ++ P ++ E +
Sbjct: 969 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028
Query: 1085 --RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142
R +Q + + L+ + +++ E+N+ LQ E Q + T + Q+ E N
Sbjct: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQAL------KTQLKQL-ETQNNNLQAQ 1081
Query: 1143 LCSLKEELIFAQEEK--IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKL-----QKAV 1195
+ +L+ + + QE+ ++ Q+E T+ +Q T + LLI + ++V
Sbjct: 1082 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1141
Query: 1196 SEECSYFLQTLCSVLGEYYTPALKCEVNAEDKEN----SGDYISENEDPELQDYRYEVQD 1251
+E S++ ++ L E A + E+ G S +++ E+ E +D
Sbjct: 1142 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV-----EHRD 1196
Query: 1252 FQENMHTLLNK--VTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHS 1309
++ + LL + E+ K+L ++ + + + + E+ + L E +S
Sbjct: 1197 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY--KKLCGENDRLNHTYS 1254
Query: 1310 Q-MTNLEDIDVNHKSKLSSLQD--LEKTKLE-------EQVQELESLISSLQQQ---LKE 1356
Q + E + +HK+ S L + LE+T+LE EQ Q+L+ + L Q L +
Sbjct: 1255 QLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1314
Query: 1357 TEQNYEAEIHCLQKRLQAV 1375
+ N E E L ++Q +
Sbjct: 1315 LKGNLEEENRHLLDQIQTL 1333
Score = 152 bits (385), Expect = 5e-36
Identities = 278/1275 (21%), Positives = 558/1275 (43%), Gaps = 224/1275 (17%)
Query: 152 DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGL----QQLQEFEAAIKQRDGII 207
+S HL + ELA + +I L +ELEE TE L Q+L++ E +K+
Sbjct: 244 ESRQHLSV---ELADAKAKIRRLRQELEEK-----TEQLLDCKQELEQMEIELKRLQQEN 295
Query: 208 TQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRN-STHSSTAADLLQA 266
L ++ + AR +DE + E + KL+ + + + E L + + + +L +
Sbjct: 296 MNLLSDARSARMYRDE-LDALREKAVRVDKLESEVSRYK--ERLHDIEFYKARVEELKED 352
Query: 267 KQQILTHQQQLEEQDHLLEDYQKKKEDF-TMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
Q +L + LE+Q LE + + + ++ LQ K K+++ME ++ ++ EE+
Sbjct: 353 NQVLLETKTMLEDQ---LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
Query: 326 EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN---MKLELTN 382
E+ +E + ++E ++++ +L Q+ + + E+ + +KLE+ N
Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
Query: 383 SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442
+ ++ +++L TV+ ++ K + +ME+E QR +++ E+
Sbjct: 470 -----QSLTKTVEELRTTVDSVEGNASK--------ILKMEKENQRLSKKV-----EILE 511
Query: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR-----SYSNITVNEDQIKLMNVAINE 497
+IVQ KQ L Q+ + + + K ++E + S I + E + + +N ++
Sbjct: 512 NEIVQEKQSL--QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569
Query: 498 LNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK 557
L + Q + + K E+ IL E ++ + ++ F + QI++ + E+ +
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESI---KETSSKLSKIEFEKRQIKKELEHYKEKGER 626
Query: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE--KEKNAVLDRMA 615
E L +E KE EL + ++TN KI E +E +++N+ L+R
Sbjct: 627 AEELENELHHLE-------------KENELLQK-KITNLKITCEKIEALEQENSELEREN 672
Query: 616 ESQEAELERLR--TQLLFSHEEELSKLKEDLEIEHRINIEKLK------DNLGIHYKQQI 667
+ L+ + T L S E+E S+L E+ +E R N+E LK L + K+ +
Sbjct: 673 RKLKKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKE-L 730
Query: 668 DGLQNEMSQKIETMQ--FEK-DNLITKQNQLILEISKL--------KDLQQSLVNSKSEE 716
+ + ++ + +E ++ F+K + L L +E +L K +QQ + S+ ++
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ--LESELQD 788
Query: 717 MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE 776
+ ++ LQK +E L+ K LE+E + L+ +T LEK K+ E + + Q E +
Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK 848
Query: 777 NSILKDEKKTLEDMLKIHTPVSQE-----ERLIFLDSIKSKSKDSVWEKEIEI--LIEEN 829
++ L++ + ++ K + +S+E E + L ++ ++K+ V I+I L+
Sbjct: 849 DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908
Query: 830 EDL---KQQCIQLNEEIEK----------QRNTFSFAEKNFEVNYQELQEEYACLLK--- 873
EDL K + Q+N ++EK + E++ + Y+ L+ + LK
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL 968
Query: 874 -VKDD--------LEDSKN-KQELEYKSKLKALNEELHLQRIN-PTTVKMKSSVFDEDKT 922
+K++ LE+S N Q+L + K N E QR + V+ + ED
Sbjct: 969 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028
Query: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKS 982
+ E+ E ++ ++ ++L +R L L QLKQ + + L ++ +
Sbjct: 1029 WERESQE----TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084
Query: 983 LKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV--SSLLDGVVTMTSRGAEGSVSKVNK 1040
L +++ VSL+ N Q+ QV S+L ++ ++ A+ + +
Sbjct: 1085 L--QRQTVSLQ--------EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ--S 1132
Query: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100
S E++ +++++ +++ + LI DH K L Q SE + L +
Sbjct: 1133 SLENENESVIKEREDLKSL-------YDSLIKDH----EKLELLHERQASEYESLISKHG 1181
Query: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 1160
LKS +L ++ H D Y + + Q+ ++++
Sbjct: 1182 TLKSAHKNLEVE--------------HRDLEDRYNQ--------------LLKQKGQLED 1213
Query: 1161 LQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSV---LGEYYTPA 1217
L+K+ ++E + M LL K + V+ E + LC L Y+
Sbjct: 1214 LEKMLKVEQEKM-------------LLENKNHETVAAE----YKKLCGENDRLNHTYSQL 1256
Query: 1218 LK-CEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR 1276
LK EV D +N ++ + +L+ R E + +K+ E+Y +L + T+
Sbjct: 1257 LKETEVLQTDHKNLKSLLNNS---KLEQTRLEAE---------FSKLKEQYQQLDITSTK 1304
Query: 1277 LSKIWGQQTDGMKLEFGEEN---LPKEETEFLSIHSQM-TNLEDIDVNH---KSKLSSLQ 1329
L+ + +K EEN L + +T L + + N+E D+ H + + L
Sbjct: 1305 LNN-QCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLN 1363
Query: 1330 DL--EKTKLEEQVQE 1342
+L +K KLEE++ +
Sbjct: 1364 ELRRQKEKLEEKIMD 1378
Score = 150 bits (379), Expect = 2e-35
Identities = 294/1339 (21%), Positives = 555/1339 (41%), Gaps = 232/1339 (17%)
Query: 1591 RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ---------EEIKRL--NRQLAQ 1639
++E + + Q T+ AH++++ +E+ LQ E+I+ L N L
Sbjct: 138 KEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL 197
Query: 1640 RSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT 1699
+ ID + SE L EE + L L A +SS Q+ G+ E +
Sbjct: 198 KRLIDERDEHSETIIELSEERDGLHFLPHA----------SSSAQSPCGSPGMKRTESRQ 247
Query: 1700 FKEKEL-DRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILD 1758
EL D K + + R L++ +LL E+ + ++ + + + +L
Sbjct: 248 HLSVELADAKAK------IRRLRQELEEKTEQLLDCKQELEQMEIELKR-LQQENMNLL- 299
Query: 1759 RSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEG 1818
S + ++ ++R E +A + E+ RV D+ S +DI + EE
Sbjct: 300 ----SDARSARMYRDELDA-----LREKAVRV-DKLESEVSRYKERLHDIEFYKARVEEL 349
Query: 1819 TELSQRLVRSG------FAGT--------EIDPENEELMLNISS-RLQAAVE-KLLEAIS 1862
E +Q L+ + GT E++ EN +L + ++ ++ K +E +
Sbjct: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
Query: 1863 ETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE-----------ELRE-------RLH 1904
E + LE A Q + M ES E + + E E+ E +L
Sbjct: 410 EENMTLEMA---QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 1905 EESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964
E+++ + EL ++G A + E++ Q + ++ LE E++ LQ +
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
Query: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE----KLEVQCQAEKVRDDLQ 2020
+ + +E+ L + E ++ + + L QE E L + + Q AE D++
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586
Query: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER 2080
K+ K L ++E S+ ++E EK RQ + LE EK E+A + E+E
Sbjct: 587 KENKILHESIKETSSKLSKIEFEK-------RQIKKELEHYKEK-----GERAEELENEL 634
Query: 2081 DVFQQE---IQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR 2137
++E +QK LK+ E + E+E+ LK+ D L E L++
Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK 694
Query: 2138 DIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDA 2197
+ + +EE LE R R +E S Q + K + + + + LE+ L+A
Sbjct: 695 ENSQLDEE--NLELR-RNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL-LKASFKK 750
Query: 2198 IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE--------IQK-----KESTTRL 2244
+R E L+ + ++ ++ LEN N+++QQL +L+ +QK K S+ RL
Sbjct: 751 TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
Query: 2245 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI----IQEKEVEIDQLNEQ 2300
++LE+ENK + + +L E D + ++ + A+I ++E V+I L ++
Sbjct: 811 EQLEKENKSLEQETSQL-----EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 2301 VTKLQQQLKITTDN----KVIEEKN-ELIRDLETQIECLMSDQECVKRNREEEIEQLNEV 2355
L +++ I ++ K +E++N EL++ I+ L++ +E + + + + +Q+N
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV-SEKLKTQQMNND 924
Query: 2356 IEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMK 2413
+EKL EL IG H D K ++ KL L++ +E E++ ++
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDRYK-----LLESKLESTLKKSLEIKEEKIAALE 979
Query: 2414 NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDA 2473
L+E+ QL QEL ++K+ E++++ Q E +V +
Sbjct: 980 ARLEESTNYNQQLRQELKTVKKNYEALKQRQD------------------EERMVQSSPP 1021
Query: 2474 LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFET 2533
+ +N+ +S E + ++ ++ RL+++E + E Q+K ++ Q
Sbjct: 1022 ISGEDNKWERESQETTRE--LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN--- 1076
Query: 2534 EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLR 2593
LQ +I+ LQ+ QT+S + + T +Q N
Sbjct: 1077 -NLQAQILALQR-----------------------------QTVSLQEQNTTLQTQN--- 1103
Query: 2594 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGN 2653
+ L + S L SQ TSL+ + Q+ I + + LE E N
Sbjct: 1104 --------AKLQVENSTLNSQ----STSLMNQNAQLLIQQSS-LENE------------N 1138
Query: 2654 EKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE 2713
E +E+E +S D L +E+ +E +A ES+ +K K
Sbjct: 1139 ESVIKEREDLKSLYD--------SLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1190
Query: 2714 KLQEELLVKETNMTSLQK-DLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPI 2772
+++ L N QK L + L +EK+ + K ET E KK C
Sbjct: 1191 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND--- 1247
Query: 2773 KLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSS-EEVTEIISQFTEKIEK 2830
+L+ + + T + + ++ + L+ N+ + Q L++E S +E + + + K+
Sbjct: 1248 RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNN 1307
Query: 2831 MQEL--HAAEILDMESRHI 2847
EL L+ E+RH+
Sbjct: 1308 QCELLSQLKGNLEEENRHL 1326
Score = 149 bits (376), Expect = 5e-35
Identities = 302/1358 (22%), Positives = 579/1358 (42%), Gaps = 216/1358 (15%)
Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQ----QTELSRISGGKENTASSKQAHAVCQ 1482
N++ + + + EQ EEV K+++ + Q + + RI G +T ++ AH
Sbjct: 104 NVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAH---- 159
Query: 1483 QEQHYFNEMKLSQDQI-GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH----- 1536
E+ +Q+ + Q E D+ +E+ +PL K + H K L+ D H
Sbjct: 160 -----IQEVTHNQENVFDLQWMEVTDMS-QEDIEPLLKNMALHLKR-LIDERDEHSETII 212
Query: 1537 DIPESKDCVLTISEEMFSKDKTF----IVRQSIHDEISVSSMDA--------------SR 1578
++ E +D + + S + R +SV DA +
Sbjct: 213 ELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTE 272
Query: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638
QL+ +++LE M EL R QE+ R A M R++ + L+E+ R+++ +
Sbjct: 273 QLLDCKQELEQMEIELKRLQQENMNLLSDARSARM-----YRDELDALREKAVRVDKLES 327
Query: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ 1698
+ S E + +EEL+ Q+ L + L +L + ++ +E + E +
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387
Query: 1699 TFK------EKELDRKP-EDVPPEILSNERYALQKANNRL-----LKILLEVVKTTAAVE 1746
K E+++DRK E++ E ++ E Q + L L+ + + + A +
Sbjct: 388 KAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ 447
Query: 1747 ETIGRHV-------LGILDRSSKS---------------QSSASLIWRSEAE---ASVKS 1781
+++G V L L+ ++S + +AS I + E E S K
Sbjct: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507
Query: 1782 CVHEEHTRVTDESIPSYS--GSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPEN 1839
+ E +S+ + D+ + + K E E S+R ++ ++ EN
Sbjct: 508 EILENEIVQEKQSLQNCQNLSKDLMKEKAQL-EKTIETLRENSERQIKI------LEQEN 560
Query: 1840 EELMLNISSRLQAA----------VEK----LLEAISETSSQLEHAKVTQTELMRESFRQ 1885
E L +SS Q + +EK L E+I ETSS+L + + ++ +E
Sbjct: 561 EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620
Query: 1886 KQEATESLKCQEELRERLHEESRAREQLAVELSKAE---GVIDGYADEKTLFERQIQEKT 1942
K++ + EEL LH + E L +++ + I+ E + ER+ ++
Sbjct: 621 KEKGERA----EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
Query: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
+D + + +L+ LE E Q+ EE L R E++K A QL E ++L
Sbjct: 677 KTLDSFKN----LTFQLESLEKENSQLDEENLELRRNVESLKC-ASMKMAQLQLENKELE 731
Query: 2003 KEKLEVQCQAEKVRDDLQK----QVKALEIDVEEQ-VSRFIELEQEK----NTELMDLRQ 2053
EK +++ E ++ +K +V +D+E Q + + +E +K +EL DL
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 2054 QNQALEK-------------QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
+NQ L+K QLEK K L+++ E ++ ++E ++L QQ ++ +
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI--KD 849
Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR--DIQERNEEIEK-----LEFRV 2153
+ E+ + + N KE E+ + KE R ++++ N+E+ K ++ V
Sbjct: 850 TTLEENNVK----IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 2154 RELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2213
E + T Q D + K L+ E L E+ DR + + LE L
Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTL- 964
Query: 2214 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2273
++ LE K E++ L +LE EST Q+L QE K K + E L ++ +
Sbjct: 965 --KKSLEIKEEKIAALEARLE----ESTNYNQQLRQELKTVKKNYE--ALKQRQDEERMV 1016
Query: 2274 QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-KITTDNKVIEEKNELIRDLETQIE 2332
Q + G+ + E E + ++ K++ +L ++ +N ++ + + L+TQ++
Sbjct: 1017 QSSPPISGE----DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA---LKTQLK 1069
Query: 2333 CLMSDQECVKRNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQLD 2389
L E N + +I L LQ++ L K + +L+ ++ SL +Q
Sbjct: 1070 QL----ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1125
Query: 2390 VVIAEKLALEQQVETANEEMTFMKNV---LKETNFKMNQLTQELFSLKRERES-VEKIQS 2445
++ ++ +LE + E+ +E +K++ L + + K+ L + S E ES + K +
Sbjct: 1126 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS---EYESLISKHGT 1182
Query: 2446 IPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLE 2505
+ N+ ++H + +++ + L+ LE ++ +E + LE
Sbjct: 1183 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE--------------KMLKVEQEKMLLE 1228
Query: 2506 S----TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL 2561
+ TV+A+ +L ++ Q ETE+LQ NL+ ++ + + Q +L
Sbjct: 1229 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN----SKLEQTRL 1284
Query: 2562 EAVQEYAKFCQDNQTISSEPERTNIQ--NLNQLR---EDE---LGSDISALTLRISELES 2613
EA E++K + Q + + N Q L+QL+ E+E L I L L+ L
Sbjct: 1285 EA--EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
Query: 2614 QVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE 2651
Q +E +E+ Q I + N L ++K+ LE +K+++
Sbjct: 1343 QNMESKDLFHVEQRQY-IDKLNELRRQKEKLE-EKIMD 1378
Score = 140 bits (353), Expect = 2e-32
Identities = 303/1470 (20%), Positives = 593/1470 (40%), Gaps = 253/1470 (17%)
Query: 1929 DEKTLFERQIQEKTDI----IDRLEQELLCASNRLQELEAEQQQ----IQEERELLSRQK 1980
+++ +F+ Q E TD+ I+ L + + RL + E + + EER+ L
Sbjct: 166 NQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLP 225
Query: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
A + P ++ TE +E+ D + ++ R +
Sbjct: 226 HASSSAQSPCGSPGMKRTESRQHLSVELA-------------------DAKAKIRRLRQE 266
Query: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
+EK +L+D +Q+ + +E +L+++ QQE L
Sbjct: 267 LEEKTEQLLDCKQELEQMEIELKRL------------------QQENMNL---------- 298
Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF---RVRELE 2157
+S+ ++ A +++ D E + ++L+ ++ E + +EF RV EL+
Sbjct: 299 --LSDARS------ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 2158 QALLVSADTFQKVEDRKHFGAVEA-------KPELSLEVQLQAERDAIDRKEKEITNLEE 2210
+ V +T +ED+ + K L L+ +L D K+I L E
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 2211 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE-----------NKLFKDDME 2259
E E+ K + LH+ E+++ T+ L E Q+ ++L K +ME
Sbjct: 411 --ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
Query: 2260 KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEE 2319
L + +T D + G ++I+ + E E +L+++V L+ + I + + ++
Sbjct: 469 NQSLTKTVEELRTTVDS--VEGNASKIL-KMEKENQRLSKKVEILENE--IVQEKQSLQN 523
Query: 2320 KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2379
L +DL + L E ++ N E +I+ L + E L Q ++++ Q++ ++A + +
Sbjct: 524 CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVK 583
Query: 2380 EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERES 2439
+ + L I E + ++E ++ KE + +L EL L++E E
Sbjct: 584 DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENEL 643
Query: 2440 VEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLET 2499
++K I +L ++E + E++ EN+ K+ + S NL
Sbjct: 644 LQK-----------KITNLKITCEKIEALEQENSELERENRKLKKTLD-----SFKNLTF 687
Query: 2500 RLLQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIVEEKVAA 2553
+L LE S D E + + ++ ++ Q Q E + L+ + L+K + E + A
Sbjct: 688 QLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL-ELLKA 746
Query: 2554 ALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELES 2613
+ +LE Y +NQ + E +N + + QL + L+ E+E+
Sbjct: 747 SFKKTERLEV--SYQGLDIENQRLQKTLENSN-KKIQQLESE----------LQDLEMEN 793
Query: 2614 QVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLK 2673
Q ++ + LE+ ++ LEKE K LE + +KKQ EKE KR Q E+
Sbjct: 794 QTLQKN----LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 2674 TTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDL 2733
TT E +N + G L E+ E+ YKE +L+E
Sbjct: 850 TTLE--ENNVKIG------NLEKENKTLSKEIGIYKESCVRLKE---------------- 885
Query: 2734 SQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793
LEKE++ V K+A + + L + + S+ T ++ +N
Sbjct: 886 ----------------LEKENKELV---KRATIDIKTLVTLREDLVSEKLKTQQM--NND 924
Query: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETL 2853
++ + I +N + E+ T+ + +E E + L+++ I+ E
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTD---DRYKLLESKLESTLKKSLEIKEEKIAALEAR 981
Query: 2854 KREHYVAVQLLKEECGTLKAVIQCLRSKEG-----SSIPELAHSDAYQTREICSSDSGSD 2908
E Q L++E T+K + L+ ++ S P ++ D RE S ++ +
Sbjct: 982 LEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE--SQETTRE 1039
Query: 2909 WGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDG 2968
L + I E ++ + ++K L +N Q+L+L S
Sbjct: 1040 ------LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS-- 1091
Query: 2969 EDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLL 3028
L+E+ + T ++ + +V +S+ + +S S L
Sbjct: 1092 ------------LQEQNTTLQTQNA------------KLQVENSTLNSQSTSLMNQNAQL 1127
Query: 3029 ALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRR 3088
+QQ LE + + R +L +L + LE + Q EY++ + + +
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSL-YDSLIKDHEKLELLHERQASEYESLIS--KHGTLK 1184
Query: 3089 SLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN-----IQQKQSQMLEMQV-ELSS 3142
S ++ H + R L +++ + +++L+ ++ K + + + +L
Sbjct: 1185 SAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG 1244
Query: 3143 MKDRATELQEQLSSEKMVV----AELKSELAQTKLELETTLKAQHKHLKE-LEAFRLEVK 3197
DR QL E V+ LKS L +KLE +T L+A+ LKE + +
Sbjct: 1245 ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE-QTRLEAEFSKLKEQYQQLDITST 1303
Query: 3198 DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL 3257
++ LL+ + ++++R L L++ + + ++ ++ +E Q+Q
Sbjct: 1304 KLNNQCELLSQLKGNLEEENRHL---LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID 1360
Query: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR--NLELQVLLESEK--VRIREMS 3313
+LN L Q+++L ++KI Q YD +G L+++ L++S+K R R+ S
Sbjct: 1361 KLNELRRQKEKL----EEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKS 1416
Query: 3314 STLDRERELHAQLQSSDGTGQSRPPLPSED 3343
TL R SS+G Q LP +D
Sbjct: 1417 LTLTPTRS-----DSSEGFLQ----LPHQD 1437
Score = 131 bits (329), Expect = 1e-29
Identities = 203/993 (20%), Positives = 450/993 (45%), Gaps = 146/993 (14%)
Query: 2 EDEERQKKLEAGKAKLAQFRQ--RKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQ 59
E++ KK+E + ++ Q +Q + Q+ + K++ + KT + + S ++Q
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 60 SQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEI-STTADDCSSEV 118
+ SS R S + E+ + +E E++I + + SS++
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVK---------------DIEKENKILHESIKETSSKL 603
Query: 119 NGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNREL 178
+ F R K +E E Y E+G + E +E+EL + E E L +++
Sbjct: 604 SKIEFEKRQIK-----KELEH-----YKEKGER-----AEELENELHHLEKENELLQKKI 648
Query: 179 EEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKL 238
+++T ++ EA + Q + L++ R+ +T+ F LT Q + L
Sbjct: 649 TNLKIT--------CEKIEA--------LEQENSELERENRKLKKTLDSFKNLTFQLESL 692
Query: 239 QIQFQQLQASET-LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDF--T 295
+ + QL LR + S A + A+ Q L +++ E++ L + + K F T
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQ-LENKELESEKEQLKKGLELLKASFKKT 751
Query: 296 MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK-DKLTT 354
++ + + + K +ENSNK+ IQ+ E+ +++L E E +TL+ ++L
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKK-IQQLESELQDL-----EMENQTLQKNLEELKI 805
Query: 355 ADKLLGELQEQ---IVQKNQEIKNMKLELTNSKQKERQSSE-------EIKQLMGTVEEL 404
+ K L +L+++ + Q+ +++ K +L ++ RQ +E E +G +E+
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 405 QKRNHKD-SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM 463
K K+ ++ V+ E E + K RA +D + +V ++++L+ E++
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI---KTLVTLREDLVS------EKL 916
Query: 464 KTRH-KGEMENALRSYSNITVNEDQIKLMNVAINE----LNIKLQDTNSQKEKLKEELGL 518
KT+ ++E I +N++++ + ++ L KL+ T + ++KEE
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA 976
Query: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA 578
LE + +EE + +Q+++ +T+ + L + V+ + +S
Sbjct: 977 ALEAR----------LEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--SPPISG 1024
Query: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638
+++ E E E K+K ++E E+N + +AE + L+TQL E + +
Sbjct: 1025 EDNKWERE-SQETTRELLKVKDRLIEVERNNA------TLQAEKQALKTQLK-QLETQNN 1076
Query: 639 KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 698
L+ + R + + N + + Q LQ E S T+ + +L+ + QL+++
Sbjct: 1077 NLQAQILALQRQTVSLQEQNTTL--QTQNAKLQVENS----TLNSQSTSLMNQNAQLLIQ 1130
Query: 699 ISKLKDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEK--------GTLEQEVQEL 748
S L++ +S++ + + +L + ++ +++E+L + + + GTL+ + L
Sbjct: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1190
Query: 749 QLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808
+++ + ++++ N L ++ QLE +LK E++ + K H V+ E + + ++
Sbjct: 1191 EVE----HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1246
Query: 809 IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868
+ S KE E+L ++++LK + N ++E+ R E + +L+E+Y
Sbjct: 1247 DRLNHTYSQLLKETEVLQTDHKNLKS--LLNNSKLEQTR---------LEAEFSKLKEQY 1295
Query: 869 ACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL 928
L D+ +K + E S+LK +L+ N + ++ +++T + + +
Sbjct: 1296 QQL-----DITSTKLNNQCELLSQLKG-----NLEEENRHLLDQIQTLMLQNRTLLEQNM 1345
Query: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRLSD 961
E ++ + + ++KL +R+K +L +++ D
Sbjct: 1346 ESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1378
Score = 116 bits (291), Expect = 4e-25
Identities = 314/1519 (20%), Positives = 612/1519 (40%), Gaps = 257/1519 (16%)
Query: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQE------ 2043
V+ L + + KLE Q +KV +D ++ L I V + + E Q+
Sbjct: 43 VDGVFLNQVMLQINPKLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSL 102
Query: 2044 KNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK--VVPRFQ 2101
N ++ ++ ++++K+ L A+ + +++ F + IQ L+ K V Q
Sbjct: 103 PNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQ-KKEEFIERIQGLDFDTKAAVAAHIQ 161
Query: 2102 PISEHQTREVEQLANHLKEKTDKCSELLLSKE--QLQRDIQERNEEIEKLEFRVRELEQA 2159
++ +Q + + + + + E LL L+R I ER+E E + EL +
Sbjct: 162 EVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSET----IIELSEE 217
Query: 2160 LLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEK------EITNLEEQLE 2213
D HF P S Q + R E E+ + + ++
Sbjct: 218 -----------RDGLHF-----LPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIR 261
Query: 2214 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2273
+ R+ELE K E++ +LE + E L+ L+QEN D + E DA+
Sbjct: 262 RLRQELEEKTEQLLDCKQELEQMEIE----LKRLQQENMNLLSDARSARMYRDELDAL-- 315
Query: 2274 QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIEC 2333
+EK V +D+L +V++ + E + D+E
Sbjct: 316 --------------REKAVRVDKLESEVSRYK----------------ERLHDIEFY--- 342
Query: 2334 LMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT---SMNAHSLSEEADSLKHQLDV 2390
+ R EE+++ N+V+ + + L + + T S H L +E LK +L
Sbjct: 343 ---------KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHD 393
Query: 2391 VIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENS 2450
+ E+ +++E EE ++ K++ + L EL + R E + P+ S
Sbjct: 394 MEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE----LSEAPQKS 449
Query: 2451 VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSA 2510
+ ++ L+ + + + K++E E I+ +E +L V
Sbjct: 450 LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 2511 KDLELTQCYKQIKDMQEQGQF---ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY 2567
+ E+ Q + +++ Q + E L+K I L++ E ++ LE E+
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI-------LEQENEH 562
Query: 2568 AKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE 2627
NQT+SS +R+ I ++++ E + I L I E S++ ++ EK
Sbjct: 563 L-----NQTVSSLRQRSQISAEARVKDIEKENKI--LHESIKETSSKLSKIE----FEKR 611
Query: 2628 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGF 2687
Q++ ++ EK ++ EL+ NE EKE + + + LK T E + E+
Sbjct: 612 QIKKELEHYKEKGERAEELE-----NELHHLEKENELLQKKITNLKITCEKIEALEQ--- 663
Query: 2688 FNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK--- 2744
E L E+ K L S+K +L E L KE + L ++ ++R ++ K
Sbjct: 664 --ENSELERENRKLKKTLDSFKNLTFQL--ESLEKENSQ--LDEENLELRRNVESLKCAS 717
Query: 2745 ---EKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
+L + KE E+E ++ KK K ++ + G + NQ Q ++N
Sbjct: 718 MKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG---LDIENQRLQKTLEN 774
Query: 2802 AGIQIN-LQSECSSEEVTEIISQFTEKIEKMQELHAA----EILDMESRHIS-ETETLKR 2855
+ +I L+SE E+ Q + ++EL + E L+ E++ + ET L++
Sbjct: 775 SNKKIQQLESELQDLEMENQTLQ-----KNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Query: 2856 EHYVAVQLLKEECGTLK--AVIQCLRSKEGS-SIPELAHSDAYQTREICSSDSGSDWGQG 2912
+ + L++E L+ A I+ +E + I L + ++EI G
Sbjct: 830 DK----KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI-----------G 874
Query: 2913 IYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHS 2972
IY +ES K+ K L++ + +++L E S E
Sbjct: 875 IY---------------KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS--EKLK 917
Query: 2973 IQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQ 3032
QQ++ N + L + K+ L +E ++D + + + +L L++
Sbjct: 918 TQQMN-----------NDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKK 966
Query: 3033 VFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS 3092
LE + +AA L ++ L Q ++ Y+A Q+ D ++
Sbjct: 967 S-LEIKEEKIAALEARLE-----ESTNYNQQLRQELKTVKKNYEALK---QRQDEERMVQ 1017
Query: 3093 EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQE 3152
+ + N K E+ES++ ++ELL+ +KDR E++
Sbjct: 1018 SSPPISGEDN------KWERESQETTRELLK-------------------VKDRLIEVER 1052
Query: 3153 QLSSEKMVVAELKSELAQTKLE---LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDT 3209
++ + LK++L Q + + L+ + A + L+ ++ + ++ + N T
Sbjct: 1053 NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1112
Query: 3210 LASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ- 3268
L S+ L +++ L E +E EDLK +S + + +L LL E+Q
Sbjct: 1113 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1172
Query: 3269 ---------LLNESQQKIE-SQRMLYDA--QLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
L + + +E R L D QL +++G+ +L+ +L KV +M
Sbjct: 1173 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML---KVEQEKMLLEN 1229
Query: 3317 DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3376
+ A+ + G S+ LLKE + L+ H + LLN + KL+ +
Sbjct: 1230 KNHETVAAEYKKLCGENDRLNHTYSQ-LLKETE-VLQTDHKNLKSLLNNS---KLEQTRL 1284
Query: 3377 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3436
+ K ++ +++ T + N + + + +L+ +E+ R L + Q+ L L+ + L
Sbjct: 1285 EAEFSKLKEQYQQLDITSTKLNNQCE-LLSQLKGNLEEENRHLLD---QIQTLMLQNRTL 1340
Query: 3437 QGIMQEFQKQELEREEKRE 3455
+ Q + ++L E+R+
Sbjct: 1341 --LEQNMESKDLFHVEQRQ 1357
Score = 112 bits (279), Expect = 9e-24
Identities = 238/1133 (21%), Positives = 449/1133 (39%), Gaps = 180/1133 (15%)
Query: 2626 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES 2685
K ++ + + EK ++LL+ ++ LE Q E E KR Q+ L L +
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELE-----QMEIELKRLQQENMNL-----LSDARSAR 306
Query: 2686 GFFNELEALRAESVAT---KAELASYKEK----------AEKLQEELLVKETNMTSLQKD 2732
+ +EL+ALR ++V ++E++ YKE+ E+L+E+ V T L+
Sbjct: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366
Query: 2733 LSQVR---DHLAEA-KEKLSILEKEDETEVQESKKACMFEPLP---IKLSKSIASQTDGT 2785
L R D L E KE L + K + E++ E L + L + D +
Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426
Query: 2786 L-------KISSSNQTPQILVKNAGIQIN-------LQSECSSEEVTEIISQFTEKIEKM 2831
L +IS +++ + K+ G ++N L+ E ++ +T+ + + ++ +
Sbjct: 427 LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486
Query: 2832 QELHAAEILDMESRH--------------ISETETLKREHYVAVQLLKEECGTLKAVIQC 2877
E +A++IL ME + + E ++L+ ++ L+KE+ L+ I+
Sbjct: 487 -EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK-AQLEKTIET 544
Query: 2878 LRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATD 2937
LR I L + + + + S Q I++E R ++ E
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSL--------------RQRSQISAEARVKDIEKENK 590
Query: 2938 SFPKKIK---GLLRAVHNEGMQVLSLTESPYSDGE-DHSIQQVSEPWLEERKAYINTISS 2993
+ IK L + E Q+ E GE ++ +E + I++
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650
Query: 2994 LKDLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA 3051
LK K++ Q +E+ ++ + D L L+ LE+ + L EL
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES--LEKENSQLDEENLELRR 708
Query: 3052 LGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR--RSLLSEIQALHAQMNGRKITLK 3109
+++ + ++Q + E ++ E L+K ++ + + L G I +
Sbjct: 709 --NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 3110 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ------EQLSSEKMVVAE 3163
R Q++ + S + IQQ +S++ ++++E +++ EL+ EQL E + +
Sbjct: 767 RLQKTLENSNK----KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 3164 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL--------NDTLASE-- 3213
S+L + K +LE ++K L++ + E+KD T E + + N TL+ E
Sbjct: 823 ETSQLEKDKKQLE----KENKRLRQ----QAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
Query: 3214 -QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ------- 3265
K+S LEKE +L + D + L L+ L S+K + Q+N LE+
Sbjct: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
Query: 3266 ---QKQLLNESQQKIESQRMLYDAQLSEEQGRNLE--------LQVLLESE---KVRIRE 3311
K+ L +Q + + L +++L ++LE L+ LE ++R+
Sbjct: 935 IGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 994
Query: 3312 MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3371
T+ + E Q Q + QS PP+ ED K E ELL ++ +
Sbjct: 995 ELKTVKKNYEALKQRQDEERMVQSSPPISGED-----NKWERESQETTRELLKVKDRL-I 1048
Query: 3372 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431
+ + ++ ++Q + L+ + N Q ++ LQ + LQ Q + Q KL +
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 3432 EGQRL---------QGIMQEFQKQELERE-----EKRESRRILYQNLNEPTTWSLTSDRT 3477
E L Q Q+ LE E ++RE + LY SL D
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD--------SLIKDHE 1160
Query: 3478 RNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERL 3537
+ +L E + S Y LI +G + LE+ + L+ ++L + +
Sbjct: 1161 KLELLH-----ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE 1215
Query: 3538 QFETADDEDFIWVQENIDEIILQLQKLTGQQG-----------EEPSLVSPSTSCGSLTE 3586
+ + E + +N + + + +KL G+ E L + + SL
Sbjct: 1216 KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN 1275
Query: 3587 RLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3639
+ L S+L E+ L KL Q Q + +R L+
Sbjct: 1276 NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1328
Score = 96.7 bits (239), Expect = 4e-19
Identities = 270/1363 (19%), Positives = 566/1363 (41%), Gaps = 205/1363 (15%)
Query: 651 NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710
+IE L N+ +H K+ ID ++E S+ I + E+D L + S
Sbjct: 185 DIEPLLKNMALHLKRLIDE-RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT 243
Query: 711 NSKSEEMTLQINELQKEIEILRQEEKEKGT----LEQEVQELQLKTELLEKQMKEKENDL 766
S+ + +++++ + + +I LRQE +EK +QE+++++++ + L+++ +D
Sbjct: 244 ESR-QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
Query: 767 QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEKEIEIL 825
+ A++ + EK D K+ + VS+ +ERL ++ K++ +E L
Sbjct: 303 RS--ARMYRDELDALREKAVRVD--KLESEVSRYKERLHDIEFYKAR---------VEEL 349
Query: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885
E+N+ L + L +++E R + ++K E+ + LQ +K L D + ++
Sbjct: 350 KEDNQVLLETKTMLEDQLEGTR---ARSDKLHELEKENLQ--------LKAKLHDMEMER 398
Query: 886 ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945
+++ K + + E + L+ ++ +S + ++ T E+ E +K + +L
Sbjct: 399 DMDRKKIEELMEENMTLEMAQKQSMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457
Query: 946 EVTKREKLEL-SQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH- 1003
++ KLE+ +Q L+ E+L+ + K LK EKE L +++EI+ N
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVE--GNASKILKMEKENQRLS-KKVEILENEI 514
Query: 1004 -NRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVG 1062
+++Q+C L+ + E ++ + ++ + KI+ ++ N TV
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQL-----EKTIETLRENSERQIKILEQENEHL-NQTVS 568
Query: 1063 EESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSL 1122
++ Q ++ E+ ++ + EN L + + S+ + +++ E ++I L
Sbjct: 569 SLRQRSQ--------ISAEARVKDIE-KENKILHESIKETSSKLS--KIEFEKRQIKKEL 617
Query: 1123 VYSTHVDQVREYMENE-----KDKALCSLKEELIFAQEEKIKEL-QKIHQLELQTMKTQE 1176
+ + E +ENE K+ L K + EKI+ L Q+ +LE + K ++
Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE 1236
T D K L + L+K S+ L+ +V ++ E+KE +
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN 1296
+ EL ++ + E + L+ + K L+ KI +++ LE +
Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQK--TLENSNKKIQQLESELQDLEMENQT 795
Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356
L K NLE++ ++ K +L L+ E LE++ +LE L+++ K
Sbjct: 796 LQK-------------NLEELKISSK-RLEQLEK-ENKSLEQETSQLEKDKKQLEKENKR 840
Query: 1357 TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEF 1416
Q E + ++T+ + + G+ K+N
Sbjct: 841 LRQQAE------------IKDTTL---------------EENNVKIGNLEKEN----KTL 869
Query: 1417 SGEFGVKEETNI-VKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSK 1475
S E G+ +E+ + +K LEK+ +E ++ + +++ +E+ S K
Sbjct: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL--------------REDLVSEK 915
Query: 1476 QAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDP 1535
QQ + ++ ++IG L+KE H ++ S D
Sbjct: 916 ---LKTQQMNNDLEKLTHELEKIG-----------------LNKERLLHDEQ---STDDR 952
Query: 1536 HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQ--E 1593
+ + ESK T+ + + K++ ++ +E S + ++QL ++L+ +++ E
Sbjct: 953 YKLLESK-LESTLKKSLEIKEEKIAALEARLEE----STNYNQQL---RQELKTVKKNYE 1004
Query: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE 1653
++Q Q+ ++ + + +RE QE +E +K +R + +N L +E++
Sbjct: 1005 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVER--NNATLQAEKQ 1062
Query: 1654 --RVLLEELEALK-----QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELD 1706
+ L++LE Q+ R+ + + +N++ QTQN + +VE T +
Sbjct: 1063 ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA---KLQVENSTLNSQSTS 1119
Query: 1707 RKPED----VPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSK 1762
++ + L NE ++ K L + ++K +E L +
Sbjct: 1120 LMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE----------LLHERQ 1169
Query: 1763 SQSSASLIWRSEAEASVKSCVHEEHTRVTD--ESIPSYSGSDMPRNDINMWSKVTEEGTE 1820
+ SLI + S + EH + D + G D+ KV +E
Sbjct: 1170 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ---LEDLEKMLKVEQEKML 1226
Query: 1821 LSQRLVRSGFAG-TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL- 1878
L + + A ++ EN+ L + S+L E L S L ++K+ QT L
Sbjct: 1227 LENKNHETVAAEYKKLCGENDRLN-HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285
Query: 1879 -----MRESFRQKQEATESLKCQ----EELRERLHEESR-AREQLAVELSKAEGVIDGYA 1928
++E ++Q + L Q +L+ L EE+R +Q+ + + +++
Sbjct: 1286 AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNM 1345
Query: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971
+ K LF E+ ID+L EL +L+E +Q + +
Sbjct: 1346 ESKDLFH---VEQRQYIDKL-NELRRQKEKLEEKIMDQYKFYD 1384
Score = 78.6 bits (192), Expect = 1e-13
Identities = 169/742 (22%), Positives = 317/742 (42%), Gaps = 101/742 (13%)
Query: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060
+Q Q++ E + Q + D + + +Q+V + +V + E+T + D L
Sbjct: 133 VQCQKKEEFIERIQGLDF--DTKAAVAAHIQEVTHNQENVFDLQWM-EVTDMSQEDIEPL 189
Query: 3061 LNC----LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEK 3116
L L++ I E+ + +E ++ D L + AQ +KR + +
Sbjct: 190 LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASS-SAQSPCGSPGMKRTESRQH 248
Query: 3117 PSQEL---------LEYNIQQKQSQMLEMQVELSSMKDRATELQEQ-------------- 3153
S EL L +++K Q+L+ + EL M+ LQ++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 3154 ------LSSEKMVVAELKSELAQTKLELETT--LKAQHKHLKELEAFRLEVKDKTDEVHL 3205
L + + V +L+SE+++ K L KA+ + LKE LE K +
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT------M 362
Query: 3206 LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL---NLL 3262
L D L + +S +L LEKE +L K +L D++ + +++ +L N+
Sbjct: 363 LEDQLEGTRARSDKLH-ELEKENLQL-------KAKLHDMEMERDMDRKKIEELMEENMT 414
Query: 3263 LEQ-QKQLLNES-QQKIESQRMLYDAQLSEEQGRNL--ELQVLLESEKVRIREMSSTLDR 3318
LE QKQ ++ES E +++ ++LSE ++L E+ L S +++ + +L +
Sbjct: 415 LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTK 474
Query: 3319 E-RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT- 3376
EL + S +G + E+ + L K++E + IV+ EK L + Q
Sbjct: 475 TVEELRTTVDSVEGNASKILKMEKEN--QRLSKKVEILENEIVQ-----EKQSLQNCQNL 527
Query: 3377 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3436
+ + K++ KT++T +E N+E Q K+ L+ + E L + + RQ+
Sbjct: 528 SKDLMKEKAQLEKTIETLRE-NSERQIKI--LEQENEHLNQTVSSLRQR----------- 573
Query: 3437 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3496
I E + +++E+E K IL++++ E T+ L+ +++++E ++ A
Sbjct: 574 SQISAEARVKDIEKENK-----ILHESIKE-TSSKLSKIEFEKRQIKKELEHYKEKGERA 627
Query: 3497 KLIEMNGGGTGCNHELEMIRQK---LQCVASKLQVLPQKASERLQFETADDEDFIWVQEN 3553
+ E+ E E++++K L+ K++ L Q+ SE L+ E + + +N
Sbjct: 628 E--ELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE-LERENRKLKKTLDSFKN 684
Query: 3554 IDEIILQLQKLTGQQGEEPSLVS---PSTSCGSL-TERLLRQNAELTGHISQLTEEKNDL 3609
+ + L+K Q EE + S C S+ +L +N EL QL + L
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744
Query: 3610 RNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRA 3669
+ K E Y+ + N I+ + SE + E TLQK+L+
Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ-LESELQDLEMENQTLQKNLEEL 803
Query: 3670 EAEVYKL-KAELRNDSLLQTLS 3690
+ +L + E N SL Q S
Sbjct: 804 KISSKRLEQLEKENKSLEQETS 825
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 166 bits (420), Expect = 4e-40
Identities = 294/1277 (23%), Positives = 546/1277 (42%), Gaps = 185/1277 (14%)
Query: 183 VTYGTEGLQQLQEFEAAIKQRDGI---ITQLTANLQQARREKDETMREFLELTEQSQKLQ 239
VT+ E + LQ E ++ I + + +L++ E+DE +EL+E+ L
Sbjct: 163 VTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH 222
Query: 240 IQFQQLQASET-------LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE 292
++++ R + + +L AK +I +Q+LEE+ L D +++ E
Sbjct: 223 FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282
Query: 293 DFTMQISFLQEK----------IKVYEMEQDK------KVENSNKEEIQEKETI------ 330
+++ LQ++ ++Y E D +V+ E + KE +
Sbjct: 283 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY 342
Query: 331 ---IEEL--NTKIIEEEKKTLE--LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383
+EEL + +++ E K LE L+ +DK L EL+++ +Q ++ +M++E
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDK-LHELEKENLQLKAKLHDMEME---- 397
Query: 384 KQKERQSSEEIKQLMGTVEELQKRNHKDS---QFETDIVQRMEQETQRKLEQLRAELDEM 440
+ +R+ EE+ + T+E QK++ +S +E + + R + ++ + L E++E+
Sbjct: 398 RDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457
Query: 441 YGQQIVQMKQELIRQHMAQ-MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499
++++++ E Q + + +EE++T NA + N+ K + + NE+
Sbjct: 458 TSSRLLKLEME--NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515
Query: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559
+ Q + + K+ +++EK L++ +E L RE +R + + ++ LN
Sbjct: 516 QEKQSLQNCQNLSKD----LMKEKAQLEKTIETL-------RENSERQIKILEQENEHLN 564
Query: 560 EAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM----- 614
+ SL + AE + KE ++ HE+ + KL +E EK + +
Sbjct: 565 QTVSSLRQRSQISAE-ARVKDIEKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 615 ----AESQEAELERL--RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
AE E EL L +LL L E +E + N E ++N + K+ +D
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL--KKTLD 680
Query: 669 GLQNEMSQ----KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
+N Q + E Q +++NL ++N L+ + +K Q L N +E+ + +L
Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN---KELESEKEQL 737
Query: 725 QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
+K +E+L+ K+ LE Q L ++ + L+K ++ +Q QLE+E L+ E
Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMEN 793
Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844
+TL+ L E L I SK + + EKE + L +E L++ QL +E +
Sbjct: 794 QTLQKNL---------EEL----KISSKRLEQL-EKENKSLEQETSQLEKDKKQLEKENK 839
Query: 845 KQRNTFSFAEKNFE---VNYQELQEEYACLLK-VKDDLEDSKNKQELEYKSKLKALNEEL 900
+ R + E V L++E L K + E +ELE ++K +
Sbjct: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899
Query: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
++ T V ++ + E +T +M +EK T EL EK+ + K L Q
Sbjct: 900 DIK----TLVTLREDLVSEK----LKTQQMNNDLEKLTHEL-EKIGLNKERLLHDEQSTD 950
Query: 961 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020
D +L + E + KSL+ ++E+++ LE N+N Q ++ ++
Sbjct: 951 DSRYKLLESKLESTL----KKSLEIKEEKIAALEARLEESTNYN-----QQLRQELKTVK 1001
Query: 1021 DGVVTMTSR-GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVT 1079
+ R E V GE++K E + E +++ + D L V
Sbjct: 1002 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQ---------ETTRELLKVKDRLIEVE 1052
Query: 1080 KESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEA-QRICLSL-VYSTHVD------QV 1131
+ + AT +E L+ +L L+++ N+L+ Q+ A QR +SL +T + QV
Sbjct: 1053 RNN---ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109
Query: 1132 REYMENEKDKALCSLKEELIFAQ-------EEKIKELQKIHQLELQTMKTQETGDEGKPL 1184
N + +L + +L+ Q E IKE + + L +K E
Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-------- 1161
Query: 1185 HLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQD 1244
KL+ + S + ++L S G + EV D E+ + + + + +L+D
Sbjct: 1162 -----KLELLHERQASEY-ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG-QLED 1214
Query: 1245 YRYEVQDFQENMHTLLNK----VTEEYNKLLVLQTRLSKIWGQ--------QTDGMKLEF 1292
++ QE M L NK V EY KL RL+ + Q QTD L+
Sbjct: 1215 LEKMLKVEQEKM-LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273
Query: 1293 GEENLPKEET----EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLIS 1348
N E+T EF + Q L+ ++ L L K LEE+ + L I
Sbjct: 1274 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL-KGNLEEENRHLLDQIQ 1332
Query: 1349 SLQQQLKE-TEQNYEAE 1364
+L Q + EQN E++
Sbjct: 1333 TLMLQNRTLLEQNMESK 1349
Score = 154 bits (390), Expect = 1e-36
Identities = 274/1258 (21%), Positives = 551/1258 (43%), Gaps = 189/1258 (15%)
Query: 152 DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGL----QQLQEFEAAIKQRDGII 207
+S HL + ELA + +I L +ELEE TE L Q+L++ E +K+
Sbjct: 244 ESRQHLSV---ELADAKAKIRRLRQELEEK-----TEQLLDCKQELEQMEIELKRLQQEN 295
Query: 208 TQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRN-STHSSTAADLLQA 266
L ++ + AR +DE + E + KL+ + + + E L + + + +L +
Sbjct: 296 MNLLSDARSARMYRDE-LDALREKAVRVDKLESEVSRYK--ERLHDIEFYKARVEELKED 352
Query: 267 KQQILTHQQQLEEQDHLLEDYQKKKEDF-TMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
Q +L + LE+Q LE + + + ++ LQ K K+++ME ++ ++ EE+
Sbjct: 353 NQVLLETKTMLEDQ---LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
Query: 326 EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN---MKLELTN 382
E+ +E + ++E ++++ +L Q+ + + E+ + +KLE+ N
Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
Query: 383 SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442
+ ++ +++L TV+ ++ K + +ME+E QR +++ E+
Sbjct: 470 -----QSLTKTVEELRTTVDSVEGNASK--------ILKMEKENQRLSKKV-----EILE 511
Query: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR-----SYSNITVNEDQIKLMNVAINE 497
+IVQ KQ L Q+ + + + K ++E + S I + E + + +N ++
Sbjct: 512 NEIVQEKQSL--QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569
Query: 498 LNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK 557
L + Q + + K E+ IL E ++ + ++ F + QI++ + E+ +
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESI---KETSSKLSKIEFEKRQIKKELEHYKEKGER 626
Query: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE--KEKNAVLDRMA 615
E L +E KE EL + ++TN KI E +E +++N+ L+R
Sbjct: 627 AEELENELHHLE-------------KENELLQK-KITNLKITCEKIEALEQENSELEREN 672
Query: 616 ESQEAELERLR--TQLLFSHEEELSKLKEDLEIEHRINIEKLK------DNLGIHYKQQI 667
+ L+ + T L S E+E S+L E+ +E R N+E LK L + K+ +
Sbjct: 673 RKLKKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKE-L 730
Query: 668 DGLQNEMSQKIETMQ--FEK-DNLITKQNQLILEISKL--------KDLQQSLVNSKSEE 716
+ + ++ + +E ++ F+K + L L +E +L K +QQ + S+ ++
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ--LESELQD 788
Query: 717 MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE 776
+ ++ LQK +E L+ K LE+E + L+ +T LEK K+ E + + Q E +
Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK 848
Query: 777 NSILKDEKKTLEDMLKIHTPVSQE-----ERLIFLDSIKSKSKDSVWEKEIEI--LIEEN 829
++ L++ + ++ K + +S+E E + L ++ ++K+ V I+I L+
Sbjct: 849 DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908
Query: 830 EDL---KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQE 886
EDL K + Q+N ++EK + N E + Q K+ + +S K+
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968
Query: 887 LEYK-SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA-ETLEMGEVVEKDTTELMEK 944
LE K K+ AL E L+ +++ + K + A + + E + + + + +
Sbjct: 969 LEIKEEKIAAL--EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1026
Query: 945 LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004
+RE E ++ L + ++L + + L E ++LK + +Q+ + N+N
Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ--------NNN 1078
Query: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064
+ + Q SL + T+ ++ A K+ EN T+ +
Sbjct: 1079 LQAQILALQRQTVSLQEQNTTLQTQNA---------------------KLQVENSTLNSQ 1117
Query: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS-------EQNDLRLQMEAQR 1117
S L+ + + ++SSL +EN+ + KE LKS + L L E Q
Sbjct: 1118 S--TSLMNQNAQLLIQQSSLE----NENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1171
Query: 1118 ICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQET 1177
+ S H + E + + + Q+ ++++L+K+ ++E + M
Sbjct: 1172 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM----- 1226
Query: 1178 GDEGKPLHLLIGKLQKAVSEECSYFLQTLCSV---LGEYYTPALK-CEVNAEDKENSGDY 1233
LL K + V+ E + LC L Y+ LK EV D +N
Sbjct: 1227 --------LLENKNHETVAAE----YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL 1274
Query: 1234 ISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG 1293
++ + +L+ R E + +K+ E+Y +L + T+L+ + +K
Sbjct: 1275 LNNS---KLEQTRLEAE---------FSKLKEQYQQLDITSTKLNN-QCELLSQLKGNLE 1321
Query: 1294 EEN---LPKEETEFLSIHSQM-TNLEDIDVNH---KSKLSSLQDL--EKTKLEEQVQE 1342
EEN L + +T L + + N+E D+ H + + L +L +K KLEE++ +
Sbjct: 1322 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379
Score = 149 bits (375), Expect = 7e-35
Identities = 303/1359 (22%), Positives = 580/1359 (42%), Gaps = 217/1359 (15%)
Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQ----QTELSRISGGKENTASSKQAHAVCQ 1482
N++ + + + EQ EEV K+++ + Q + + RI G +T ++ AH
Sbjct: 104 NVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAH---- 159
Query: 1483 QEQHYFNEMKLSQDQI-GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH----- 1536
E+ +Q+ + Q E D+ +E+ +PL K + H K L+ D H
Sbjct: 160 -----IQEVTHNQENVFDLQWMEVTDMS-QEDIEPLLKNMALHLKR-LIDERDEHSETII 212
Query: 1537 DIPESKDCVLTISEEMFSKDKTF----IVRQSIHDEISVSSMDA--------------SR 1578
++ E +D + + S + R +SV DA +
Sbjct: 213 ELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTE 272
Query: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638
QL+ +++LE M EL R QE+ R A M R++ + L+E+ R+++ +
Sbjct: 273 QLLDCKQELEQMEIELKRLQQENMNLLSDARSARM-----YRDELDALREKAVRVDKLES 327
Query: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ 1698
+ S E + +EEL+ Q+ L + L +L + ++ +E + E +
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387
Query: 1699 TFK------EKELDRKP-EDVPPEILSNERYALQKANNRL-----LKILLEVVKTTAAVE 1746
K E+++DRK E++ E ++ E Q + L L+ + + + A +
Sbjct: 388 KAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ 447
Query: 1747 ETIGRHV-------LGILDRSSKS---------------QSSASLIWRSEAE---ASVKS 1781
+++G V L L+ ++S + +AS I + E E S K
Sbjct: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507
Query: 1782 CVHEEHTRVTDESIPSYS--GSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPEN 1839
+ E +S+ + D+ + + K E E S+R ++ ++ EN
Sbjct: 508 EILENEIVQEKQSLQNCQNLSKDLMKEKAQL-EKTIETLRENSERQIKI------LEQEN 560
Query: 1840 EELMLNISSRLQAA----------VEK----LLEAISETSSQLEHAKVTQTELMRESFRQ 1885
E L +SS Q + +EK L E+I ETSS+L + + ++ +E
Sbjct: 561 EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620
Query: 1886 KQEATESLKCQEELRERLHEESRAREQLAVELSKAE---GVIDGYADEKTLFERQIQEKT 1942
K++ + EEL LH + E L +++ + I+ E + ER+ ++
Sbjct: 621 KEKGERA----EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
Query: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002
+D + + +L+ LE E Q+ EE L R E++K A QL E ++L
Sbjct: 677 KTLDSFKN----LTFQLESLEKENSQLDEENLELRRNVESLKC-ASMKMAQLQLENKELE 731
Query: 2003 KEKLEVQCQAEKVRDDLQK----QVKALEIDVEEQ-VSRFIELEQEK----NTELMDLRQ 2053
EK +++ E ++ +K +V +D+E Q + + +E +K +EL DL
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 2054 QNQALEK-------------QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
+NQ L+K QLEK K L+++ E ++ ++E ++L QQ ++ +
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI--KD 849
Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR--DIQERNEEIEK-----LEFRV 2153
+ E+ + + N KE E+ + KE R ++++ N+E+ K ++ V
Sbjct: 850 TTLEENNVK----IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 2154 RELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2213
E + T Q D + K L+ E L E+ D + K LE +LE
Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYK---LLESKLE 962
Query: 2214 Q-FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMS 2272
++ LE K E++ L +LE EST Q+L QE K K + E L ++ +
Sbjct: 963 STLKKSLEIKEEKIAALEARLE----ESTNYNQQLRQELKTVKKNYE--ALKQRQDEERM 1016
Query: 2273 TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-KITTDNKVIEEKNELIRDLETQI 2331
Q + G+ + E E + ++ K++ +L ++ +N ++ + + L+TQ+
Sbjct: 1017 VQSSPPISGE----DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA---LKTQL 1069
Query: 2332 ECLMSDQECVKRNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQL 2388
+ L E N + +I L LQ++ L K + +L+ ++ SL +Q
Sbjct: 1070 KQL----ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQN 1125
Query: 2389 DVVIAEKLALEQQVETANEEMTFMKNV---LKETNFKMNQLTQELFSLKRERES-VEKIQ 2444
++ ++ +LE + E+ +E +K++ L + + K+ L + S E ES + K
Sbjct: 1126 AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS---EYESLISKHG 1182
Query: 2445 SIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQL 2504
++ N+ ++H + +++ + L+ LE ++ +E + L
Sbjct: 1183 TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE--------------KMLKVEQEKMLL 1228
Query: 2505 ES----TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQ 2560
E+ TV+A+ +L ++ Q ETE+LQ NL+ ++ + + Q +
Sbjct: 1229 ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN----SKLEQTR 1284
Query: 2561 LEAVQEYAKFCQDNQTISSEPERTNIQ--NLNQLR---EDE---LGSDISALTLRISELE 2612
LEA E++K + Q + + N Q L+QL+ E+E L I L L+ L
Sbjct: 1285 LEA--EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLL 1342
Query: 2613 SQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE 2651
Q +E +E+ Q I + N L ++K+ LE +K+++
Sbjct: 1343 EQNMESKDLFHVEQRQY-IDKLNELRRQKEKLE-EKIMD 1379
Score = 147 bits (371), Expect = 2e-34
Identities = 287/1354 (21%), Positives = 562/1354 (41%), Gaps = 208/1354 (15%)
Query: 2039 ELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
E Q + EL D + + + L ++LE+ EQ +D + E + + E+++L+Q+
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKT----EQLLDCKQELEQMEIELKRLQQE----- 294
Query: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF---RVRE 2155
+S+ ++ A +++ D E + ++L+ ++ E + +EF RV E
Sbjct: 295 NMNLLSDARS------ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE 348
Query: 2156 LEQALLVSADTFQKVEDRKHFGAVEA-------KPELSLEVQLQAERDAIDRKEKEITNL 2208
L++ V +T +ED+ + K L L+ +L D K+I L
Sbjct: 349 LKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL 408
Query: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQEN-----------KLFKDD 2257
E E E+ K + LH+ E+++ T+ L E Q++ +L K +
Sbjct: 409 ME--ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 2258 MEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVI 2317
ME L + +T D + G ++I++ E E +L+++V L+ + I + + +
Sbjct: 467 MENQSLTKTVEELRTTVDS--VEGNASKILK-MEKENQRLSKKVEILENE--IVQEKQSL 521
Query: 2318 EEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSL 2377
+ L +DL + L E ++ N E +I+ L + E L Q ++++ Q++ ++A +
Sbjct: 522 QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEAR 581
Query: 2378 SEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER 2437
++ + L I E + ++E ++ KE + +L EL L++E
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN 641
Query: 2438 ESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINL 2497
E ++K I +L ++E + E++ EN+ K+ + S NL
Sbjct: 642 ELLQK-----------KITNLKITCEKIEALEQENSELERENRKLKKTLD-----SFKNL 685
Query: 2498 ETRLLQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIVEEKV 2551
+L LE S D E + + ++ ++ Q Q E + L+ + L+K +E +
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE-LL 744
Query: 2552 AAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISEL 2611
A+ +LE Y +NQ + E +N + + QL + L+ E+
Sbjct: 745 KASFKKTERLEV--SYQGLDIENQRLQKTLENSN-KKIQQLESE----------LQDLEM 791
Query: 2612 ESQVVEMHTSLILEKEQVEIAEKNV--LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDV 2669
E+Q ++ + E+++I+ K + LEKE K LE + +KKQ EKE KR Q
Sbjct: 792 ENQTLQKNL------EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 2670 EVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSL 2729
E+ TT E +N + G L E+ E+ YKE +L+E
Sbjct: 846 EIKDTTLE--ENNVKIG------NLEKENKTLSKEIGIYKESCVRLKE------------ 885
Query: 2730 QKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2789
LEKE++ V K+A + + L + + S+ T ++
Sbjct: 886 --------------------LEKENKELV---KRATIDIKTLVTLREDLVSEKLKTQQM- 921
Query: 2790 SSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISE 2849
+N ++ + I +N + E+ T+ + +E E + L+++ I+
Sbjct: 922 -NNDLEKLTHELEKIGLNKERLLHDEQSTD--DSRYKLLESKLESTLKKSLEIKEEKIAA 978
Query: 2850 TETLKREHYVAVQLLKEECGTLKAVIQCLRSKEG-----SSIPELAHSDAYQTREICSSD 2904
E E Q L++E T+K + L+ ++ S P ++ D RE S +
Sbjct: 979 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE--SQE 1036
Query: 2905 SGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESP 2964
+ + L + I E ++ + ++K L +N Q+L+L
Sbjct: 1037 TTRE------LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090
Query: 2965 YSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRG 3024
S L+E+ + T ++ + +V +S+ + +S S
Sbjct: 1091 VS--------------LQEQNTTLQTQNA------------KLQVENSTLNSQSTSLMNQ 1124
Query: 3025 ELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK 3084
L +QQ LE + + R +L +L + LE + Q EY++ + +
Sbjct: 1125 NAQLLIQQSSLENENESVIKEREDLKSL-YDSLIKDHEKLELLHERQASEYESLIS--KH 1181
Query: 3085 ADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN-----IQQKQSQMLEMQV- 3138
+S ++ H + R L +++ + +++L+ ++ K + + +
Sbjct: 1182 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYK 1241
Query: 3139 ELSSMKDRATELQEQLSSEKMVV----AELKSELAQTKLELETTLKAQHKHLKE-LEAFR 3193
+L DR QL E V+ LKS L +KLE +T L+A+ LKE +
Sbjct: 1242 KLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE-QTRLEAEFSKLKEQYQQLD 1300
Query: 3194 LEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQK 3253
+ ++ LL+ + ++++R L L++ + + ++ ++ +E Q+
Sbjct: 1301 ITSTKLNNQCELLSQLKGNLEEENRHL---LDQIQTLMLQNRTLLEQNMESKDLFHVEQR 1357
Query: 3254 QRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR--NLELQVLLESEK--VRI 3309
Q +LN L Q+++L ++KI Q YD +G L+++ L++S+K R
Sbjct: 1358 QYIDKLNELRRQKEKL----EEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRE 1413
Query: 3310 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3343
R+ S TL R SS+G Q LP +D
Sbjct: 1414 RQKSLTLTPTRS-----DSSEGFLQ----LPHQD 1438
Score = 134 bits (336), Expect = 2e-30
Identities = 206/989 (20%), Positives = 452/989 (45%), Gaps = 137/989 (13%)
Query: 2 EDEERQKKLEAGKAKLAQFRQ--RKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQ 59
E++ KK+E + ++ Q +Q + Q+ + K++ + KT + + S ++Q
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 60 SQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEI-STTADDCSSEV 118
+ SS R S + E+ + +E E++I + + SS++
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVK---------------DIEKENKILHESIKETSSKL 603
Query: 119 NGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNREL 178
+ F R K +E E Y E+G + E +E+EL + E E L +++
Sbjct: 604 SKIEFEKRQIK-----KELEH-----YKEKGER-----AEELENELHHLEKENELLQKKI 648
Query: 179 EEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKL 238
+++T ++ EA + Q + L++ R+ +T+ F LT Q + L
Sbjct: 649 TNLKIT--------CEKIEA--------LEQENSELERENRKLKKTLDSFKNLTFQLESL 692
Query: 239 QIQFQQLQASET-LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDF--T 295
+ + QL LR + S A + A+ Q L +++ E++ L + + K F T
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQ-LENKELESEKEQLKKGLELLKASFKKT 751
Query: 296 MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK-DKLTT 354
++ + + + K +ENSNK+ IQ+ E+ +++L E E +TL+ ++L
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKK-IQQLESELQDL-----EMENQTLQKNLEELKI 805
Query: 355 ADKLLGELQEQ---IVQKNQEIKNMKLELTNSKQKERQSSE-------EIKQLMGTVEEL 404
+ K L +L+++ + Q+ +++ K +L ++ RQ +E E +G +E+
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 405 QKRNHKD-SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM 463
K K+ ++ V+ E E + K RA +D + +V ++++L+ E++
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI---KTLVTLREDLVS------EKL 916
Query: 464 KTRH-KGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522
KT+ ++E I +N++++ + ++ KL ++ + LK+ L I EE
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST-LKKSLE-IKEE 974
Query: 523 KCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESR 582
K A LE +EE + +Q+++ +T+ + L + V+ + +S +++
Sbjct: 975 KIAA---LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--SPPISGEDNK 1029
Query: 583 KELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKE 642
E E E K+K ++E E+N + +AE + L+TQL E + + L+
Sbjct: 1030 WERE-SQETTRELLKVKDRLIEVERNNA------TLQAEKQALKTQLK-QLETQNNNLQA 1081
Query: 643 DLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL 702
+ R + + N + + Q LQ E S T+ + +L+ + QL+++ S L
Sbjct: 1082 QILALQRQTVSLQEQNTTL--QTQNAKLQVENS----TLNSQSTSLMNQNAQLLIQQSSL 1135
Query: 703 KDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEK--------GTLEQEVQELQLKT 752
++ +S++ + + +L + ++ +++E+L + + + GTL+ + L+++
Sbjct: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE- 1194
Query: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
+ ++++ N L ++ QLE +LK E++ + K H V+ E + + ++ +
Sbjct: 1195 ---HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1251
Query: 813 SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872
S KE E+L ++++LK + N ++E+ R E + +L+E+Y L
Sbjct: 1252 HTYSQLLKETEVLQTDHKNLKS--LLNNSKLEQTR---------LEAEFSKLKEQYQQL- 1299
Query: 873 KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGE 932
D+ +K + E S+LK +L+ N + ++ +++T + + +E +
Sbjct: 1300 ----DITSTKLNNQCELLSQLKG-----NLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350
Query: 933 VVEKDTTELMEKLEVTKREKLELSQRLSD 961
+ + + ++KL +R+K +L +++ D
Sbjct: 1351 LFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379
Score = 110 bits (275), Expect = 3e-23
Identities = 174/834 (20%), Positives = 354/834 (42%), Gaps = 114/834 (13%)
Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
E+E QKK+ K + + Q + + + +K K+ S K+ L + SQ
Sbjct: 640 ENELLQKKITNLKITCEKIEALE-QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
Query: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
+E + + VES + + Q + ELESE G
Sbjct: 699 LDEENLELRRNVESLKCASMKMAQL----------QLENKELESEKEQLK-------KGL 741
Query: 122 SFVMRTGKPTNLLREEEFGVD--DSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELE 179
+ + K T L G+D + ++ ++S ++ +ESEL + E + L + LE
Sbjct: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
Query: 180 EMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQ 239
E++++ ++ L+QL++ +++Q Q ++K + +E L +Q++
Sbjct: 802 ELKIS--SKRLEQLEKENKSLEQ----------ETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 240 IQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ-KKKEDFTMQI 298
++ + + + ++ K+ + ++ +E L++ K T++
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909
Query: 299 SFLQEKIKVYEMEQD-KKVENS------NKEEIQEKETIIEELNTKIIEEE-----KKTL 346
+ EK+K +M D +K+ + NKE + E ++ K++E + KK+L
Sbjct: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL 969
Query: 347 ELK-DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQ 405
E+K +K+ + L E Q QE+K +K KQ RQ E + Q +
Sbjct: 970 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ--RQDEERMVQSSPPI---- 1023
Query: 406 KRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKT 465
+ +D+++E R QET R+L +++ L E + ++ A ++ K
Sbjct: 1024 --SGEDNKWE-----RESQETTRELLKVKDRLIE-------------VERNNATLQAEKQ 1063
Query: 466 RHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCA 525
K +++ +N+ ++ V++ E N LQ +Q KL+ E + + +
Sbjct: 1064 ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ---TQNAKLQVENSTLNSQSTS 1120
Query: 526 LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL 585
L Q Q + +Q S NE + EDLK+ S + ++L
Sbjct: 1121 LMNQ-----------------NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1163
Query: 586 ELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE 645
EL HE + + Y+ + K+A + E + +LE QLL + +L L++ L+
Sbjct: 1164 ELLHERQASEYESLISKHGTLKSA--HKNLEVEHRDLEDRYNQLL-KQKGQLEDLEKMLK 1220
Query: 646 IEHRINI--EKLKDNLGIHYKQ------QIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
+E + K + + YK+ +++ +++ ++ E +Q + NL + N L
Sbjct: 1221 VEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280
Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQ-----EEKEKGTLEQEVQELQLKT 752
E ++L + + S + + +++ + +L + E+L Q EE+ + L+Q +Q L L+
Sbjct: 1281 EQTRL-EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ-IQTLMLQN 1338
Query: 753 E-LLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE---DMLKIHTPVSQEER 802
LLE+ M+ K+ E+ ++ N + + ++K E D K + P R
Sbjct: 1339 RTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1392
Score = 101 bits (251), Expect = 2e-20
Identities = 249/1188 (20%), Positives = 469/1188 (39%), Gaps = 260/1188 (21%)
Query: 2626 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES 2685
K ++ + + EK ++LL+ ++ LE Q E E KR Q+ L L +
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELE-----QMEIELKRLQQENMNL-----LSDARSAR 306
Query: 2686 GFFNELEALRAESVAT---KAELASYKEK----------AEKLQEELLVKETNMTSLQKD 2732
+ +EL+ALR ++V ++E++ YKE+ E+L+E+ V T L+
Sbjct: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366
Query: 2733 LSQVR---DHLAEA-KEKLSILEKEDETEVQESKKACMFEPLP---IKLSKSIASQTDGT 2785
L R D L E KE L + K + E++ E L + L + D +
Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426
Query: 2786 L-------KISSSNQTPQILVKNAGIQIN-------LQSECSSEEVTEIISQFTEKIEKM 2831
L +IS +++ + K+ G ++N L+ E ++ +T+ + + ++ +
Sbjct: 427 LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486
Query: 2832 QELHAAEILDMESRH--------------ISETETLKREHYVAVQLLKEECGTLKAVIQC 2877
E +A++IL ME + + E ++L+ ++ L+KE+ L+ I+
Sbjct: 487 -EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA-QLEKTIET 544
Query: 2878 LRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATD 2937
LR I L + + + + S S I++E R ++ E
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQ--------------ISAEARVKDIEKENK 590
Query: 2938 SFPKKIK---GLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT-ISS 2993
+ IK L + E Q+ E GE + LE+ + I++
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650
Query: 2994 LKDLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA 3051
LK K++ Q +E+ ++ + D L L+ LE+ + L EL
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES--LEKENSQLDEENLELRR 708
Query: 3052 LGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR--RSLLSEIQALHAQMNGRKITLK 3109
+++ + ++Q + E ++ E L+K ++ + + L G I +
Sbjct: 709 --NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 3110 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ------EQLSSEKMVVAE 3163
R Q++ + S + IQQ +S++ ++++E +++ EL+ EQL E + +
Sbjct: 767 RLQKTLENSNK----KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 3164 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL--------NDTLASE-- 3213
S+L + K +LE ++K L++ + E+KD T E + + N TL+ E
Sbjct: 823 ETSQLEKDKKQLEK----ENKRLRQ----QAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
Query: 3214 -QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ------- 3265
K+S LEKE +L + D + L L+ L S+K + Q+N LE+
Sbjct: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
Query: 3266 ----QKQLLNESQQKIESQRMLYDAQLSEEQGRNLE--------LQVLLESE---KVRIR 3310
+++LL++ Q +S+ L +++L ++LE L+ LE ++R
Sbjct: 935 IGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 994
Query: 3311 EMSSTLDRERELHAQLQSSDGTGQSRPPLPSED-------------LLKELQKQLE-EKH 3356
+ T+ + E Q Q + QS PP+ ED LLK + +E E++
Sbjct: 995 QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN 1054
Query: 3357 SRIVELLNETEKYKLDSLQTR-----------QQMEKDRQVHRKTLQTE----------- 3394
+ ++ + K +L L+T+ Q+ Q TLQT+
Sbjct: 1055 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1114
Query: 3395 ----------------QEANTEGQ-----KKMHELQSKVEDL-----------QRQLEE- 3421
Q+++ E + K+ +L+S + L +RQ E
Sbjct: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY 1174
Query: 3422 --------------KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP 3467
K +V DLE + Q + Q+ Q ++LE+ K E ++L +N N
Sbjct: 1175 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH- 1233
Query: 3468 TTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQ 3527
ET + Y KL G NH + ++ + + + +
Sbjct: 1234 ---------------------ETVAAEYKKLC---GENDRLNHTYSQLLKETEVLQTDHK 1269
Query: 3528 VLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ-----------QGEEPSLVS 3576
L + +T + +F ++E ++ + KL Q + E L+
Sbjct: 1270 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1329
Query: 3577 PSTSCGSLTERLLRQNAELTG--HIS--QLTEEKNDLRNMVMKLEEQI 3620
+ LL QN E H+ Q ++ N+LR KLEE+I
Sbjct: 1330 QIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
Score = 98.6 bits (244), Expect = 1e-19
Identities = 249/1199 (20%), Positives = 508/1199 (42%), Gaps = 164/1199 (13%)
Query: 651 NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710
+IE L N+ +H K+ ID ++E S+ I + E+D L + S
Sbjct: 185 DIEPLLKNMALHLKRLIDE-RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT 243
Query: 711 NSKSEEMTLQINELQKEIEILRQEEKEKGT----LEQEVQELQLKTELLEKQMKEKENDL 766
S+ + +++++ + + +I LRQE +EK +QE+++++++ + L+++ +D
Sbjct: 244 ESR-QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
Query: 767 QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEKEIEIL 825
+ A++ + EK D K+ + VS+ +ERL ++ K++ +E L
Sbjct: 303 RS--ARMYRDELDALREKAVRVD--KLESEVSRYKERLHDIEFYKAR---------VEEL 349
Query: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885
E+N+ L + L +++E R + ++K E+ + LQ +K L D + ++
Sbjct: 350 KEDNQVLLETKTMLEDQLEGTR---ARSDKLHELEKENLQ--------LKAKLHDMEMER 398
Query: 886 ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945
+++ K + + E + L+ ++ +S + ++ T E+ E +K + +L
Sbjct: 399 DMDRKKIEELMEENMTLEMAQKQSMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457
Query: 946 EVTKREKLEL-SQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH- 1003
++ KLE+ +Q L+ E+L+ + K LK EKE L +++EI+ N
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVE--GNASKILKMEKENQRLS-KKVEILENEI 514
Query: 1004 -NRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVG 1062
+++Q+C L+ + E ++ + ++ + KI+ ++ N TV
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQL-----EKTIETLRENSERQIKILEQENEHL-NQTVS 568
Query: 1063 EESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSL 1122
++ Q ++ E+ ++ + EN L + + S+ + +++ E ++I L
Sbjct: 569 SLRQRSQ--------ISAEARVKDIE-KENKILHESIKETSSKLS--KIEFEKRQIKKEL 617
Query: 1123 VYSTHVDQVREYMENE-----KDKALCSLKEELIFAQEEKIKEL-QKIHQLELQTMKTQE 1176
+ + E +ENE K+ L K + EKI+ L Q+ +LE + K ++
Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE 1236
T D K L + L+K S+ L+ +V ++ E+KE +
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN 1296
+ EL ++ + E + L+ + K L+ KI +++ LE +
Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQK--TLENSNKKIQQLESELQDLEMENQT 795
Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356
L K NLE++ ++ K +L L+ E LE++ +LE L+++ K
Sbjct: 796 LQK-------------NLEELKISSK-RLEQLEK-ENKSLEQETSQLEKDKKQLEKENKR 840
Query: 1357 TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK-KNID---- 1411
Q E + L++ + +L ++ +++ + +Y SCV+ K ++
Sbjct: 841 LRQQAEIKDTTLEENNVKIG------NLEKENKTLSK---EIGIYKESCVRLKELEKENK 891
Query: 1412 -----GTIEFSGEFGVKEETNIVKLLEKQYQEQLEE---EVAKVIVSMS--IAFAQQTEL 1461
TI+ ++E+ KL +Q LE+ E+ K+ ++ + Q T+
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
Query: 1462 SRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521
SR + S+ + ++E+ E +L + Q K+ ++ L +
Sbjct: 952 SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
Query: 1522 GEHGKEILLSNSDP---HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASR 1578
E E ++ +S P D ++ T E + KD+ I E + +++ A +
Sbjct: 1012 DE---ERMVQSSPPISGEDNKWERESQETTRELLKVKDRL------IEVERNNATLQAEK 1062
Query: 1579 QLMLNE-EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQ- 1636
Q + + +QLE L Q Q+ T L++ Q + +LQ E LN Q
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQE----QNTTLQTQNAKLQVENSTLNSQS 1118
Query: 1637 ----------LAQRSSIDNEN--LVSERERV---------------LLEELEALKQLSL- 1668
L Q+SS++NEN ++ ERE + LL E +A + SL
Sbjct: 1119 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1178
Query: 1669 -------AGREKLCCELRNSSTQTQNGNENQGEVE--EQTFKEKELDRKPEDVPPEILSN 1719
+ + L E R+ + + +G++E E+ K ++ E+ E ++
Sbjct: 1179 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1238
Query: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEAS 1778
E L N+RL +++K T V +T +++ +L+ S Q+ R EAE S
Sbjct: 1239 EYKKLCGENDRLNHTYSQLLKET-EVLQTDHKNLKSLLNNSKLEQT------RLEAEFS 1290
Score = 78.6 bits (192), Expect = 1e-13
Identities = 169/742 (22%), Positives = 317/742 (42%), Gaps = 101/742 (13%)
Query: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060
+Q Q++ E + Q + D + + +Q+V + +V + E+T + D L
Sbjct: 133 VQCQKKEEFIERIQGLDF--DTKAAVAAHIQEVTHNQENVFDLQWM-EVTDMSQEDIEPL 189
Query: 3061 LNC----LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEK 3116
L L++ I E+ + +E ++ D L + AQ +KR + +
Sbjct: 190 LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASS-SAQSPCGSPGMKRTESRQH 248
Query: 3117 PSQEL---------LEYNIQQKQSQMLEMQVELSSMKDRATELQEQ-------------- 3153
S EL L +++K Q+L+ + EL M+ LQ++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 3154 ------LSSEKMVVAELKSELAQTKLELETT--LKAQHKHLKELEAFRLEVKDKTDEVHL 3205
L + + V +L+SE+++ K L KA+ + LKE LE K +
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT------M 362
Query: 3206 LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL---NLL 3262
L D L + +S +L LEKE +L K +L D++ + +++ +L N+
Sbjct: 363 LEDQLEGTRARSDKLH-ELEKENLQL-------KAKLHDMEMERDMDRKKIEELMEENMT 414
Query: 3263 LEQ-QKQLLNES-QQKIESQRMLYDAQLSEEQGRNL--ELQVLLESEKVRIREMSSTLDR 3318
LE QKQ ++ES E +++ ++LSE ++L E+ L S +++ + +L +
Sbjct: 415 LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTK 474
Query: 3319 E-RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT- 3376
EL + S +G + E+ + L K++E + IV+ EK L + Q
Sbjct: 475 TVEELRTTVDSVEGNASKILKMEKEN--QRLSKKVEILENEIVQ-----EKQSLQNCQNL 527
Query: 3377 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3436
+ + K++ KT++T +E N+E Q K+ L+ + E L + + RQ+
Sbjct: 528 SKDLMKEKAQLEKTIETLRE-NSERQIKI--LEQENEHLNQTVSSLRQR----------- 573
Query: 3437 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3496
I E + +++E+E K IL++++ E T+ L+ +++++E ++ A
Sbjct: 574 SQISAEARVKDIEKENK-----ILHESIKE-TSSKLSKIEFEKRQIKKELEHYKEKGERA 627
Query: 3497 KLIEMNGGGTGCNHELEMIRQK---LQCVASKLQVLPQKASERLQFETADDEDFIWVQEN 3553
+ E+ E E++++K L+ K++ L Q+ SE L+ E + + +N
Sbjct: 628 E--ELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE-LERENRKLKKTLDSFKN 684
Query: 3554 IDEIILQLQKLTGQQGEEPSLVS---PSTSCGSL-TERLLRQNAELTGHISQLTEEKNDL 3609
+ + L+K Q EE + S C S+ +L +N EL QL + L
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744
Query: 3610 RNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRA 3669
+ K E Y+ + N I+ + SE + E TLQK+L+
Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ-LESELQDLEMENQTLQKNLEEL 803
Query: 3670 EAEVYKL-KAELRNDSLLQTLS 3690
+ +L + E N SL Q S
Sbjct: 804 KISSKRLEQLEKENKSLEQETS 825
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 164 bits (415), Expect = 2e-39
Identities = 307/1503 (20%), Positives = 616/1503 (40%), Gaps = 156/1503 (10%)
Query: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV------RELEQALLVS 2163
++ +L L ++ EL L + ++ + E++ +I ++ R+ E + A +
Sbjct: 215 QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274
Query: 2164 ADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKN 2223
+++ D+ + L L+ E+ +DRK I L E+ +L
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRK---INQLSEENGDLSFKLREFA 331
Query: 2224 EEVQQLHMQLEIQKKESTTRLQE-LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGK 2282
+QQL L +E + QE LE++ +L K+ L A+++ + +++ +L GK
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE----LSAALQDKKCLEEKNE-ILQGK 386
Query: 2283 FAQII-----------QEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQI 2331
+Q+ QEK + + + T Q+ + +N ++ + E++ Q
Sbjct: 387 LSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQ 446
Query: 2332 ECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVV 2391
E + + + + EEE +QL+ +I LQ ++N+ Q + L Q+ +
Sbjct: 447 EAKLLAE---RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503
Query: 2392 IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ-LTQELFSLKRERESVEKIQSIPENS 2450
+E L ++ ++E+ +K KE ++ Q L Q+ + + R VE++ S
Sbjct: 504 TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSS----- 558
Query: 2451 VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSA 2510
L + + +L+ V + ++ + E + S+ + L QLE+
Sbjct: 559 ------SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612
Query: 2511 KDLELTQCYKQIK---DMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY 2567
K +L +Q++ + ++ Q Q++ L + VEE A V + E +
Sbjct: 613 KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE--LQACVETARQEQHEAQ 670
Query: 2568 AKFCQDNQTISSEPERTNIQNLNQLREDELGSDISAL--TLRISELESQVVEMHTSLILE 2625
A+ + + SE ++ + +D+L + AL +L++++ + + + LE
Sbjct: 671 AQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE 730
Query: 2626 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQD-VEVLKTTTELFHSNEE 2684
++Q I+E E + L+E ++++++E E++R+ + +E H E
Sbjct: 731 EQQRCISELKA--------ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAET 782
Query: 2685 SGFFNEL-EALRAESVATKA------ELASYKEKAEKLQEE-----LLVKETNMTSLQKD 2732
EL EA+ A+ A E+A+++E+ E Q+E + +E MT L+++
Sbjct: 783 EVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT-LKEE 841
Query: 2733 LSQVRDHLAEAKEKLSILEKEDETEV--QESKKACMFEPLPI-------------KLSKS 2777
+ R L EAKEK++ +E E ++ Q+++ A + L KL+
Sbjct: 842 CEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADD 901
Query: 2778 IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELH-- 2835
+++ + S + LV+ AG Q S +E + E +E+ Q
Sbjct: 902 LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFC 961
Query: 2836 ----AAEILDMESRHI-SETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELA 2890
A + ++ E+ + +E E L+ + +EE G + + L + G + +LA
Sbjct: 962 STQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLA 1021
Query: 2891 HSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIA---SEGRGEESESATDSFPKKIKGL- 2946
A + + + + + T + A EG+ +E +IK L
Sbjct: 1022 LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE 1081
Query: 2947 -LRAVHNEGMQVLSLTESPYSDGEDHSIQQV--SEPWLEERKAYINTISSLKDLITKMQL 3003
LR + + L+ E ++ G + +EP + +A +S L+ K Q
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141
Query: 3004 QREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNC 3063
Q A+ + S E S + L Q LEE++ L ++ L + A
Sbjct: 1142 Q--ADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV 1199
Query: 3064 LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLE 3123
+ E + Q A + + SL+S ++ + +N R++ K + E + E
Sbjct: 1200 QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN-RQVLEKEGESKELKRLVMAE 1258
Query: 3124 YNIQQKQSQMLEM-QVELSSMKDRATELQEQLSSEKMVVAEL--KSELAQTKLELETTLK 3180
QK + L + Q E +S RA E L E + E K +A L E T +
Sbjct: 1259 SEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQ 1318
Query: 3181 AQHKHL--KELEAFRLEVKDKTDEV------HLLNDTLASEQKKSRELQWALEKEKAKLG 3232
A+ +EL+A++ + K + H L SE ++ L L+ E+A
Sbjct: 1319 AERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAA-- 1376
Query: 3233 RSEERDKEELEDLKFSLESQK------QRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3286
+E+R +EELE K + + QR L + L Q+ + Q++ +++ Y
Sbjct: 1377 -AEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAE 1435
Query: 3287 QLS---------EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRP 3337
QLS E+ R L + L + + + LD+ RE + Q ++
Sbjct: 1436 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVE-----LDQAREKYVQELAAVRAD---- 1486
Query: 3338 PLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEA 3397
+E L E+Q++ + + + + E K+ L+ RQ+ +++RQ ++ +
Sbjct: 1487 ---AETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVF 1543
Query: 3398 NTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEG-------QRLQGIMQEFQKQELER 3450
E K++ EL K+ D + + ++Q++ + +G QRLQ + E Q Q ++
Sbjct: 1544 QREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQK 1603
Query: 3451 EEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNH 3510
E+ E Y+ E + + +N LQ+++ + K E+ H
Sbjct: 1604 EQAAEH----YKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENK--ELRAEAERLGH 1657
Query: 3511 ELE 3513
EL+
Sbjct: 1658 ELQ 1660
Score = 147 bits (370), Expect = 3e-34
Identities = 354/1816 (19%), Positives = 739/1816 (40%), Gaps = 291/1816 (16%)
Query: 613 RMAESQEAELERLRTQLLFSHEEELSKLKEDLE-IEHRINIEK-------LKDNLGIHYK 664
++ E E EL ++ T LL H SK D E E++I E L G++
Sbjct: 86 KVLEGSELELAKM-TMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLN 144
Query: 665 QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
+ ++ + + L +Q EI L+ Q + +S S L +
Sbjct: 145 EDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLE--LQKVASSSSGNNFLSGSPA 202
Query: 725 QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
+IL+ + + L++++ + + + LE ++ E L EK AQ+
Sbjct: 203 SPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQI----------- 251
Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE-KEIEILIEENEDLK-------QQC 836
++R+ L + K S E KE+E L ++NE L +QC
Sbjct: 252 ------------AMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQC 299
Query: 837 IQLN-EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895
L E+ + R +E+N +++++ E+A L+ L+D+ N+ E+ KA
Sbjct: 300 QDLKTEKSQMDRKINQLSEENGDLSFK--LREFASHLQ---QLQDALNELTEEHS---KA 351
Query: 896 LNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLEL 955
E L Q ++ + S +DK L EK E+ + + +L
Sbjct: 352 TQEWLEKQ----AQLEKELSAALQDKKC-----------------LEEKNEILQGKLSQL 390
Query: 956 SQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 1015
+ LS L + Q+ GE+ ++++LKQE A + + +TQ
Sbjct: 391 EEHLSQLQDNPPQEKGEVLGDVLQLETLKQE-------------------AATLAANNTQ 431
Query: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK-----IMVEDKVSFENMTVGEESKQEQL 1070
+ + ++ + T RG + + + EE K ++ + + S N++ +E ++
Sbjct: 432 LQARVE--MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQAS 489
Query: 1071 ------ILDHLPSVTKE-SSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLV 1123
+ + S+T E ++L AT ++ +L K +Q L ++ Q
Sbjct: 490 QAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQ------- 542
Query: 1124 YSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQ-ETGDEGK 1182
+Q + + ++ ++ SLK++ E+++KE+ + + Q Q T E +
Sbjct: 543 -----EQASQGLRHQVEQLSSSLKQK-----EQQLKEVAEKQEATRQDHAQQLATAAEER 592
Query: 1183 PLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPEL 1242
L + + A ++ + + L E L+ A D + ++ E EL
Sbjct: 593 EASL---RERDAALKQLEALEKEKAAKL-EILQQQLQVANEARDSAQTSVTQAQREKAEL 648
Query: 1243 QDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEET 1302
+V++ Q + T + E ++ L+ +L + T+ ++ ++ L +E+
Sbjct: 649 SR---KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL-QEQL 704
Query: 1303 EFLSIHSQMT--NLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQN 1360
+ L ++T +LE+ K + + + ++ + E E SL+ +++ KE E+
Sbjct: 705 QALKESLKVTKGSLEE----EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760
Query: 1361 YEAEIHCLQKRLQAVSESTVPPSLPVDSVVI--------TESDAQRTMYPGSCVKKNIDG 1412
A L+ RLQ + E+ + + + ES+ ++ + + ++ +
Sbjct: 761 -RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819
Query: 1413 TIEFSGEFGVKEETNIVKLLE-----KQYQEQLEEEVAKVIVSMSIAFA-QQTELSRISG 1466
+ + ++G + ++ L E +Q ++ +E+VA + + + QQ EL+ +
Sbjct: 820 SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH- 878
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526
+ A A+ Q ++ KL+ D Q K + L ++ GE +
Sbjct: 879 -------ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE--Q 929
Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586
+ S + + D EE RQ + ++ +M+ + M NE
Sbjct: 930 QETASRELVKEPARAGDRQPEWLEEQQG-------RQFCSTQAALQAMEREAEQMGNE-- 980
Query: 1587 LEDMRQELVR-QYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDN 1645
LE +R L+ Q Q+ ++ + R+ ER R + E+ R ++ +++++
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040
Query: 1646 ENL------------VSERE-------------RVLLEELEALKQLSLAGREKLCCELRN 1680
+ + ++E+E ++ELE L+Q +E+L + +
Sbjct: 1041 QRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100
Query: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
++ + +E G E K + L + + + + A L+ LE +
Sbjct: 1101 HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADS------LERSLEAER 1154
Query: 1741 TTAAVEETIGRHVLGILDRSSKSQS-SASLIWRSEAEASVKSCVHEEHTRVTDESIPSYS 1799
+ A ++ + G L+ ++ S S + ++ E + ++H++ DE +
Sbjct: 1155 ASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVA 1214
Query: 1800 -GSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858
G ++ S + EE + L+++++ E+ + L++ S + Q E+L
Sbjct: 1215 RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL----KRLVMAESEKSQKLEERLR 1270
Query: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS 1918
+ET+S A + L E ++EA + E LR+ L ++ E+L EL
Sbjct: 1271 LLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELK 1330
Query: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE-RELLS 1977
+ + E+ L Q++ + L ELL A + Q+L+AEQ ++ RE L
Sbjct: 1331 AWQEKF--FQKEQALSTLQLEHTST--QALVSELLPAKHLCQQLQAEQAAAEKRHREELE 1386
Query: 1978 RQKEAMKAEAGPVEQQLLQETEKL-----------MKEKLEVQCQAEKV----------- 2015
+ K+A AG + +LL+ +L +E+ Q +AEK
Sbjct: 1387 QSKQA----AGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK 1442
Query: 2016 --------------RDDLQKQVKALEIDV--EEQVSRFIELEQEKNTELMDLRQQNQALE 2059
R +L +Q +E+D E+ V + + T L +++++ Q+
Sbjct: 1443 AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTA 1502
Query: 2060 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK 2119
++LE M + + ER FQ+E QKL Q++ + FQ QT++VE+L+ L
Sbjct: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQ---REQTKQVEELSKKLA 1559
Query: 2120 EKTDKCSELLLSK-EQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGA 2178
+ +D+ S++ K + +Q E +E ++L+ ++ EL+ A QK + +H+
Sbjct: 1560 D-SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ------AQLSQKEQAAEHY-- 1610
Query: 2179 VEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK 2238
++Q++ + D K+++ L+EQL E+L+ +N+E++ +L + +
Sbjct: 1611 ---------KLQMEKAKTHYDAKKQQNQELQEQLRSL-EQLQKENKELRAEAERLGHELQ 1660
Query: 2239 ESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2298
++ + +E EQ + + L + +D GKF +V D L
Sbjct: 1661 QAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRD-----LGKF-------QVATDALK 1708
Query: 2299 EQVTKLQQQLKITTDN 2314
+ + + QL ++ D+
Sbjct: 1709 SREPQAKPQLDLSIDS 1724
Score = 142 bits (357), Expect = 8e-33
Identities = 254/1280 (19%), Positives = 520/1280 (40%), Gaps = 161/1280 (12%)
Query: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
EQ +Q +E + S L K+ +++E+ + E R + + +E EA++++RD
Sbjct: 543 EQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAA 602
Query: 207 ITQLTA--------------NLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETL 251
+ QL A LQ A +D + + +L + ++LQA ET
Sbjct: 603 LKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETA 662
Query: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE-- 309
R H + A + + + Q+ + QQ+ E++ + ++ K+ Q+ L+E +KV +
Sbjct: 663 RQEQHEA-QAQVAELELQLRSEQQKATEKERVAQE----KDQLQEQLQALKESLKVTKGS 717
Query: 310 MEQDKKVENSNKEEIQEKETIIEELNTK---IIEEEKK-TLELKDKLTTADKLLGELQEQ 365
+E++K+ + ++E++ I EL + ++E+ K+ EL+++ L LQ+
Sbjct: 718 LEEEKR---RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL 774
Query: 366 IVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425
E + ++ EL + + + E +QL+ V ++R ++DSQ
Sbjct: 775 GEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER-YEDSQ------------ 821
Query: 426 TQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNE 485
Q A+ M+ +Q++ +K+E + +++E K + G + S+S + ++
Sbjct: 822 ------QEEAQYGAMFQEQLMTLKEECEKARQ-ELQEAKEKVAG-----IESHSELQISR 869
Query: 486 DQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQ 545
Q +L + N L L + E++ Q+ L ++LS +E++
Sbjct: 870 QQNELAELHAN---------------LARALQQVQEKEVRAQK----LADDLSTLQEKMA 910
Query: 546 RARQTIAEQESKLNEAHKSLSTV-EDLKAEIVSASESRKE-LELKHEAEVTNYKIKLEML 603
+ +A E+ + +A + T +L E A + + E LE + + + + L+ +
Sbjct: 911 ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAM 970
Query: 604 EKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEK--------L 655
E+E AE ELERLR L+ S ++ + + R+ E+ L
Sbjct: 971 ERE--------AEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLAL 1022
Query: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715
+ + ++ NE + T+Q + +T++ E++KL+ L+ + + + E
Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQI-KELE 1081
Query: 716 EMTLQINELQKEIEILRQEEKEKGTLEQE-----------VQELQLKTELLEKQMKEKEN 764
E+ + +L++++ +E + E ++ L+ + LE+Q ++++
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141
Query: 765 DLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824
LEAE + + LE + +QE ++ + + + +++
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201
Query: 825 LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV-NYQELQEEYACLLKVKDDLEDSKN 883
+ ++ K Q + +E E++ + S E+ + N Q L++E + + +S+
Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEK 1261
Query: 884 KQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELME 943
Q+LE +L+ L E N +SS E+ + E E V ++ L +
Sbjct: 1262 SQKLE--ERLRLLQAE---TASNSARAAERSSALREEVQSLREEAEKQRVASEN---LRQ 1313
Query: 944 KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEE---VKSLKQEKEQVSLRCRELEII 1000
+L EL Q L E+ QK +S L E ++L E C++L+
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQ-- 1371
Query: 1001 INHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMT 1060
AE + + S G G + + + GE I + KV+ + T
Sbjct: 1372 AEQAAAEKRHREELEQSKQAAG-------GLRAELLRAQRELGE--LIPLRQKVAEQERT 1422
Query: 1061 VGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV----LKSEQNDLRLQMEAQ 1116
+ ++ + L + K L A EN L + N+ L+ E + R + +
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLA---EENRGLGERANLGRQFLEVELDQAREKYVQE 1479
Query: 1117 RICLSLVYSTHVDQVR----------EYMENEKDKALCSLKEELIFAQEEKIKELQKIHQ 1166
+ T + +V+ E M + + A + EE QEE+ K ++ Q
Sbjct: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
Query: 1167 LEL----QTMKTQE------TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTP 1216
LE+ QT + +E D+ + K +A E Q L + L E
Sbjct: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
Query: 1217 ALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR 1276
+ E AE + + + D + Q + Q+ QE + + L ++ +E +L R
Sbjct: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQ----QNQELQEQLRS-LEQLQKENKELRAEAER 1654
Query: 1277 LSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKL 1336
L Q G+K + E+ + S+ +Q+ + D + K D K++
Sbjct: 1655 LGH--ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAH-ADQQLRDLGKFQVATDALKSRE 1711
Query: 1337 EEQVQELESLISSLQQQLKE 1356
+ +L+ I SL +E
Sbjct: 1712 PQAKPQLDLSIDSLDLSCEE 1731
Score = 138 bits (348), Expect = 9e-32
Identities = 309/1491 (20%), Positives = 618/1491 (41%), Gaps = 187/1491 (12%)
Query: 1855 EKLLEAISETSSQLEHAKVTQTELMRE-----------SFRQKQEATESLKCQEELRERL 1903
E L + ET Q + K ++++ R+ SF+ ++ A+ + Q+ L E
Sbjct: 286 ESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELT 345
Query: 1904 HEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ------------- 1950
E S+A ++ + ++ E + +K E + + + +LE+
Sbjct: 346 EEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEK 405
Query: 1951 -ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQ 2009
E+L +L+ L+ E + L + E ++ E G E +LL E +EK
Sbjct: 406 GEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQ--- 462
Query: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Q + DLQ + L EE LEQ L Q +L +L + +
Sbjct: 463 -QLSSLITDLQSSISNLSQAKEE-------LEQASQAHGARLTAQVASLTSELTTLNATI 514
Query: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
+Q D+E + QQ +K Q + + + + S+ +VEQL++ LK+K + E+
Sbjct: 515 QQQ--DQELA-GLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
Query: 2130 LSKEQLQRD--------IQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
+E ++D +ER + + + +++LE A + ++ + A EA
Sbjct: 572 EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQV-ANEA 630
Query: 2182 KPELSLEV-QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKES 2240
+ V Q Q E+ + RK +E L+ +E R+E +V +L +QL +++++
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEE---LQACVETARQEQHEAQAQVAELELQLRSEQQKA 687
Query: 2241 TTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2300
T + + + QE KD +++ A+KES ++ + A ++E++ I +L +
Sbjct: 688 TEK-ERVAQE----KDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742
Query: 2301 VTKLQQQLKITTDNKVIEEKNELIRDLETQIECL--------------MSDQECVKRNRE 2346
L +Q K + K +EE+ + LE +++ L +++ + E
Sbjct: 743 TRSLVEQHK--RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE 800
Query: 2347 EEIEQL-------NEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2399
E EQL E E QQE A G +L EE + + +L + +E
Sbjct: 801 SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860
Query: 2400 QQVETA-----NEEMTFMKNV------LKETNFKMNQLTQELFSLKRERESVEKIQSIPE 2448
E NE N+ ++E + +L +L +L+ + + K + E
Sbjct: 861 SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE 920
Query: 2449 NSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTV 2508
V A + EL ++ ++ + Q + EE + + L +E
Sbjct: 921 TLVRKAGEQQETASREL----VKEPARAGDRQPEW--LEEQQGRQFCSTQAALQAMEREA 974
Query: 2509 SAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQK---------IVEEKVAAALVSQI 2559
EL + + + Q Q Q E ++++ L + +E+ A L ++
Sbjct: 975 EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRL 1034
Query: 2560 QLEAVQEYAKFCQDNQTIS---SEPERTNIQNLNQLREDELGS--DISALTLRISELESQ 2614
Q ++ +F + ++ +E E + Q L +LR E ++ L + +L+ Q
Sbjct: 1035 QNALNEQRVEFATLQEALAHALTEKEGKD-QELAKLRGLEAAQIKELEELRQTVKQLKEQ 1093
Query: 2615 VVEMH-------------------TSLILEKEQVEIA--EKNVLEKEKKLLELQKLLEGN 2653
+ + T LE + E++ E+ +++++ L++ LE
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAE 1153
Query: 2654 EKKQREKEKKRSPQDVEVLKTTTELFHSNEE-SGFFNELEALRAESVATKAELASYKEKA 2712
+ E++ ++ + EL HS + EL A R + +K +
Sbjct: 1154 RASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV 1213
Query: 2713 EKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPI 2772
+ ++E K + ++SL++++S + + E + + L++ E ++S+K + E L +
Sbjct: 1214 ARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQK--LEERLRL 1271
Query: 2773 KLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKM- 2831
+++ ++ + S+ + Q L + A Q +SE + + ++ E+ E++
Sbjct: 1272 LQAETASNSARAAERSSALREEVQSLREEAEKQ-----RVASENLRQELTSQAERAEELG 1326
Query: 2832 QELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAH 2891
QEL A + + TL+ EH + Q L E K + Q L++++ ++ E H
Sbjct: 1327 QELKAWQEKFFQKEQA--LSTLQLEH-TSTQALVSELLPAKHLCQQLQAEQAAA--EKRH 1381
Query: 2892 SDAYQTREICSSD-------SGSDWGQGIYLTH--SQGFDIASEGRGEESESATD-SFPK 2941
+ + + + + + G+ I L ++ A + R E++ A S K
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
Query: 2942 KIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-QQVSEPWLEE-RKAYINTISSLK-DLI 2998
K GLL A N G+ GE ++ +Q E L++ R+ Y+ +++++ D
Sbjct: 1442 KAHGLL-AEENRGL------------GERANLGRQFLEVELDQAREKYVQELAAVRADAE 1488
Query: 2999 TKM-QLQREAEVYDSSQSHESFSDWRGELLLALQ--QVFLEERSVLLAAF-RTELTALGT 3054
T++ ++QREA+ + + + + G + L+ Q F EER L A + E+
Sbjct: 1489 TRLAEVQREAQS-TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547
Query: 3055 TDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITL-KREQE 3113
T V L+ + Q ++ +Q S E Q L AQ+N + L ++EQ
Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQ-QEAQRLQAQLNELQAQLSQKEQA 1606
Query: 3114 SE--KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3171
+E K E + + K+ Q E+Q +L S++ E +E + + + EL+ +T
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKT 1666
Query: 3172 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLND-TLASEQKKSRELQ 3221
K E E T + ++ LEA +V ++ L +A++ KSRE Q
Sbjct: 1667 K-EAEQTCRHLTAQVRSLEA---QVAHADQQLRDLGKFQVATDALKSREPQ 1713
Score = 138 bits (348), Expect = 9e-32
Identities = 289/1400 (20%), Positives = 554/1400 (39%), Gaps = 189/1400 (13%)
Query: 134 LREEEFGVDDSYSEQGAQDSPTHLEMME--SELAGKQHEIEELNRELEEMRVTYGTEGLQ 191
L+ E+ +D ++ ++ ++ E S L Q + EL E + + + Q
Sbjct: 302 LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ 361
Query: 192 QLQEFEAAIKQR----------DGIITQLTANLQQAR----REKDETMREFLELTEQSQK 237
+E AA++ + G ++QL +L Q + +EK E + + L+L Q+
Sbjct: 362 LEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
Query: 238 ---LQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDF 294
L QLQA + + A LL + +QQL L+ D Q +
Sbjct: 422 AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSS---LITDLQSSISNL 478
Query: 295 TMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIE---ELNTKIIEEEKKTLELKDK 351
+ L++ + + +V + E TI + EL + ++K +L
Sbjct: 479 SQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT 538
Query: 352 LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKD 411
L ++ L+ Q+ Q + +K + +L +K+ + ++ Q + T E ++ + ++
Sbjct: 539 LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRE 598
Query: 412 SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEM 471
++ +E+E KLE L+ +L Q+ ++ + + Q + K ++
Sbjct: 599 RDAALKQLEALEKEKAAKLEILQQQL------QVANEARDSAQTSVTQAQREKAELSRKV 652
Query: 472 ENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE 531
E L++ E VA EL ++ + QK KE + +EK LQ QL+
Sbjct: 653 EE-LQACVETARQEQHEAQAQVAELELQLR---SEQQKATEKER---VAQEKDQLQEQLQ 705
Query: 532 DLVEELSFSR----EQIQRARQTIAEQESKLNEAH-KSLSTVEDLKAEIVSASE---SRK 583
L E L ++ E+ +RA + EQ+ ++E ++ S VE K E E RK
Sbjct: 706 ALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRK 765
Query: 584 ELELK-------HEAEVTNYKIKL--------------EMLEKEKNAVLDRMAESQEAEL 622
LE + H+AE + +L E L KE A +R +SQ+ E
Sbjct: 766 GLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEE- 824
Query: 623 ERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNL-GI--HYKQQIDGLQNEMS---- 675
Q +E+L LKE+ E + R +++ K+ + GI H + QI QNE++
Sbjct: 825 ----AQYGAMFQEQLMTLKEECE-KARQELQEAKEKVAGIESHSELQISRQQNELAELHA 879
Query: 676 ----------QKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ 725
+K Q D+L T Q ++ ++ L ++LV E+ EL
Sbjct: 880 NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARL-ETLVRKAGEQQETASRELV 938
Query: 726 KE--------IEILRQEEKEK--------GTLEQEVQELQLKTELLEKQMKEKENDLQEK 769
KE E L +++ + +E+E +++ + E L + E + QE+
Sbjct: 939 KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE 998
Query: 770 FAQLEAENSILKDEK----------KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE 819
Q E E + L E+ K L++ + E+ + +++ ++ E
Sbjct: 999 RGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTE 1058
Query: 820 KEIE------------ILIEENEDLKQQCIQLNEEI---EKQRNTFSFAEKNFEVNYQEL 864
KE + I+E E+L+Q QL E++ EK+ + S A+ +
Sbjct: 1059 KEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPT 1118
Query: 865 QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFV 924
+ L LE KQ+ + S ++L E + + ++ +E +
Sbjct: 1119 GPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQEL 1178
Query: 925 AETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984
+ +++ K++ + + E +++ ++ ++K+ IS L EEV L
Sbjct: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238
Query: 985 QEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGE 1044
++ + +EL+ ++ +E Q + ++ L + ++R AE S + E
Sbjct: 1239 RQVLEKEGESKELKRLV-MAESEKSQKLEERLRLLQAETASNSARAAERS-----SALRE 1292
Query: 1045 ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104
E + + E+ E V E+ +++L + L+A Q K ++ L+ L+
Sbjct: 1293 EVQSLREEA---EKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQK-EQALSTLQL 1348
Query: 1105 EQNDLRL----QMEAQRICLSLVYSTHVDQVREYMENEKDK-ALCSLKEELIFAQEE--- 1156
E + + A+ +C L + R E E+ K A L+ EL+ AQ E
Sbjct: 1349 EHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGE 1408
Query: 1157 ------KIKELQK-IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS---YFLQTL 1206
K+ E ++ QL + E K H L+ + + + E + FL+
Sbjct: 1409 LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVE 1468
Query: 1207 CSVLGEYYT---PALKCEVNAEDKENSGDYISENEDPELQDYRY---------EVQDFQE 1254
E Y A++ + E + S + E+ +Y E Q FQE
Sbjct: 1469 LDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
Query: 1255 NMHTLL-------------NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE--ENLPK 1299
L K EE +K L + SK+ Q+ ++ + GE + +
Sbjct: 1529 ERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQR 1588
Query: 1300 EETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQ 1359
+ + + +Q++ E ++K ++ + K ++Q QEL+ + SL+Q KE ++
Sbjct: 1589 LQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK-KQQNQELQEQLRSLEQLQKENKE 1647
Query: 1360 NYEAEIHCLQKRLQAVSEST 1379
AE L LQ T
Sbjct: 1648 -LRAEAERLGHELQQAGLKT 1666
Score = 132 bits (333), Expect = 5e-30
Identities = 330/1674 (19%), Positives = 665/1674 (39%), Gaps = 244/1674 (14%)
Query: 350 DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409
D L T + L++Q+ + ++LEL +++ + +I + ++ L N
Sbjct: 207 DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE 266
Query: 410 KDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKG 469
K Q + + + +E + K E L L E +Q +K E + M + + G
Sbjct: 267 K--QAASPLEPKELEELRDKNESLTMRLHETL-KQCQDLKTE--KSQMDRKINQLSEENG 321
Query: 470 EMENALRSYSNITVNEDQIKLMNVAINELNIK----LQDTNSQKEKLKEELGLILEEKCA 525
++ LR +++ ++ + A+NEL + Q+ ++ +L++EL L++K
Sbjct: 322 DLSFKLREFAS------HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC 375
Query: 526 LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL 585
L+ + E L +LS E + + + +++ E + +E LK E + + + +L
Sbjct: 376 LEEKNEILQGKLSQLEEHLSQLQDNPPQEK---GEVLGDVLQLETLKQEAATLAANNTQL 432
Query: 586 ELKHEAEVTNYKIKLEMLEKEKNAVLDR-MAESQEAELERLRTQLLFSHEEELSKLKEDL 644
+ + E ++ E ++E + +R E ++ +L L T L S LS+ KE+L
Sbjct: 433 QARVE------MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQ-SSISNLSQAKEEL 485
Query: 645 EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLI-------TKQNQLIL 697
E + + G Q+ L +E++ T+Q + L KQ QL
Sbjct: 486 EQASQAH--------GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQ 537
Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757
+ + + Q L + E+++ + QKE ++ EK++ T + Q+L E E
Sbjct: 538 TLQQQEQASQGL-RHQVEQLSSSLK--QKEQQLKEVAEKQEATRQDHAQQLATAAEEREA 594
Query: 758 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSV 817
++E++ L+ QLEA + + L+ L++ + + + K++ S
Sbjct: 595 SLRERDAALK----QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650
Query: 818 WEKEIEILIE----ENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL-- 871
+E++ +E E + + Q +L ++ ++ + E+ + +LQE+ L
Sbjct: 651 KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQ-EKDQLQEQLQALKE 709
Query: 872 -LKV-KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED----KTFVA 925
LKV K LE+ K + + + + ++E R K + +E+ K A
Sbjct: 710 SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769
Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
++GE + +T EV +RE E + +Q E++ E + +Q
Sbjct: 770 RLQQLGEAHQAET-------EVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822
Query: 986 EKEQVSLRCRELEIIIN---HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF 1042
E+ Q +E + + + +Q +V+ + SR + +++++ +
Sbjct: 823 EEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISR-QQNELAELHANL 881
Query: 1043 GEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT---QPSENDKLQKEL 1099
+ + E +V + + + QE++ E+ +R Q + + +L KE
Sbjct: 882 ARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEP 941
Query: 1100 NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIK 1159
Q + + + ++ C + +++ E M NE ++ +L E QEE+ +
Sbjct: 942 ARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQ 1001
Query: 1160 ELQKIHQLELQTMKTQETGDEGKPLHL-------LIGKLQKAVSEECSYFLQTLCSVLGE 1212
+ +++ +L TQE G L L L +LQ A++E+ F TL L
Sbjct: 1002 QEREVARL------TQERGRAQADLALEKAARAELEMRLQNALNEQRVEF-ATLQEALAH 1054
Query: 1213 YYTPALKCEVNAEDKENSG-DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL 1271
T E +D+E + + + EL++ R V+ +E L K +E+
Sbjct: 1055 ALT-----EKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQ----LAKKEKEHASGS 1105
Query: 1272 VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLE-DIDVNHKSKLSSLQD 1330
Q+ + + G KLE + K E + Q +LE ++ S+
Sbjct: 1106 GAQSEAA--GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSA 1163
Query: 1331 LE--KTKLEEQVQEL---ESLISSLQQQL----------KETEQNYEAEIHCLQKRLQAV 1375
LE + +LEE+ QEL +S ++S Q++L + E ++A++ + R +A
Sbjct: 1164 LETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV--ARGRQEAE 1221
Query: 1376 SESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQ 1435
++++ SL + ++ +E GE +E + + E +
Sbjct: 1222 RKNSLISSLEEEVSILNRQ------------------VLEKEGE---SKELKRLVMAESE 1260
Query: 1436 YQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQ 1495
++LEE + + Q E + N+A + + + ++E E Q
Sbjct: 1261 KSQKLEERLRLL----------QAETA------SNSARAAERSSALREEVQSLREEAEKQ 1304
Query: 1496 DQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSK 1555
++E ++ E G+E+ E+ F K
Sbjct: 1305 --------RVASENLRQELTSQAERAEELGQEL-----------------KAWQEKFFQK 1339
Query: 1556 DKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQ 1615
++ Q H S Q +++E + L +Q Q Q A E + H +
Sbjct: 1340 EQALSTLQLEH---------TSTQALVSELL---PAKHLCQQLQAEQAAAE---KRHREE 1384
Query: 1616 MERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLC 1675
+E+ ++ L+ E+ R R+L + I V+E+ER ++L A ++ S A + +
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGE--LIPLRQKVAEQERT-AQQLRA-EKASYAEQLSML 1440
Query: 1676 CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735
+ + G + + Q F E ELD+ E E+ + A RL ++
Sbjct: 1441 KKAHGLLAEENRGLGERANLGRQ-FLEVELDQAREKYVQELAA----VRADAETRLAEVQ 1495
Query: 1736 LEVVKTTAAVEETIGRH---VLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD 1792
E T +E ++ + +L+ + Q + A+ E T+ +
Sbjct: 1496 REAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQ---KLTAQVEQLEVFQREQTKQVE 1552
Query: 1793 ESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQA 1852
E + SD SKV + Q+L G E E + RLQA
Sbjct: 1553 ELSKKLADSDQA-------SKVQQ------QKLKAVQAQGGESQQE--------AQRLQA 1591
Query: 1853 AVEKLLEAISETSSQLEHAKVTQTELMRESF----RQKQEATESLKCQEELRERLHEESR 1908
+ +L +S+ EH K+ Q E + + +Q QE E L+ E+L++ E
Sbjct: 1592 QLNELQAQLSQKEQAAEHYKL-QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA 1650
Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL 1962
E+L EL +A G ++ E+ + T + LE ++ A +L++L
Sbjct: 1651 EAERLGHELQQA-----GLKTKEA--EQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
Score = 72.8 bits (177), Expect = 6e-12
Identities = 137/650 (21%), Positives = 270/650 (41%), Gaps = 96/650 (14%)
Query: 3074 EYQAAMECLQKADRRSLLSEIQALHAQMNG----RKITLKREQESEKPSQELLEYNIQQK 3129
E+ + ++ LQ A L+E+ H++ ++ L++E + ++ LE +
Sbjct: 329 EFASHLQQLQDA-----LNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEIL 383
Query: 3130 QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA---------QTKLELETTLK 3180
Q ++ +++ LS ++D + + ++ + + + LK E A Q ++E+ T +
Sbjct: 384 QGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETER 443
Query: 3181 AQH--KHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD 3238
Q K L E F E + + + L ++++ + EL+ A + A+L
Sbjct: 444 GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503
Query: 3239 KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLE- 3297
EL L +++ Q Q L KQ E Q ++ +Q + Q S+ +E
Sbjct: 504 TSELTTLNATIQQQDQE-------LAGLKQQAKEKQAQL-AQTLQQQEQASQGLRHQVEQ 555
Query: 3298 LQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3357
L L+ ++ +++E++ + R+ HAQ ++ +E + L E+ +
Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAA--------------EEREASLRERDA 601
Query: 3358 RIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQR 3417
+ +L EK K L+ QQ QV + + Q + T+ Q++ EL KVE+LQ
Sbjct: 602 ALKQL-EALEKEKAAKLEILQQQ---LQVANEARDSAQTSVTQAQREKAELSRKVEELQA 657
Query: 3418 QLEEKRQ-------QVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTW 3470
+E RQ QV +L+L+ + Q E ++ E+++ +E + L ++L + T
Sbjct: 658 CVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESL-KVTKG 716
Query: 3471 SLTSDRTR---------NWVLQQKIEG----ETKESNYAKLIEMNGGGTGCNHELEMIRQ 3517
SL ++ R + + K E E + +L E G G L+ + +
Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGE 776
Query: 3518 KLQCVASKLQVLPQKASERLQFE-TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVS 3576
Q ++ +VL ++ +E + + TA+ E ++ + E+ ++ Q EE +
Sbjct: 777 AHQ---AETEVLRRELAEAMAAQHTAESE----CEQLVKEVAAWRERYEDSQQEEAQYGA 829
Query: 3577 PSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRF 3636
E+L+ E +L E K + + E QI R +
Sbjct: 830 ------MFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQI--------SRQQNELA 875
Query: 3637 SLNGGANIEAIIASEKEVWNREKL-----TLQKSLKRAEAEVYKLKAELR 3681
L+ EKEV +KL TLQ+ + EV +L+ +R
Sbjct: 876 ELHANLARALQQVQEKEV-RAQKLADDLSTLQEKMAATSKEVARLETLVR 924
Score = 70.9 bits (172), Expect = 2e-11
Identities = 109/535 (20%), Positives = 231/535 (43%), Gaps = 62/535 (11%)
Query: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK-S 3166
LK++ E+ +++ LE + + + + E +++ M+ R L L +EK + L+
Sbjct: 219 LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA--LLNEKQAASPLEPK 276
Query: 3167 ELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK 3226
EL + + + E+ H+ LK+ + + E +++ L++ K RE L++
Sbjct: 277 ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336
Query: 3227 EKAKLGR-SEERDK--EELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3283
+ L +EE K +E + + LE + LQ LE++ ++L ++E
Sbjct: 337 LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396
Query: 3284 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSD-GTGQSRPPLPSE 3342
+E+G L + LE+ K +E ++ +L A+++ + GQ L +E
Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLK---QEAATLAANNTQLQARVEMLETERGQQEAKLLAE 453
Query: 3343 DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVH--RKTLQ-------- 3392
+ EE+ ++ L+ + + + Q ++++E+ Q H R T Q
Sbjct: 454 ------RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSEL 507
Query: 3393 -----TEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE 3447
T Q+ + E + + K L + L+++ Q L + ++L +++ ++Q
Sbjct: 508 TTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL 567
Query: 3448 LEREEKRESRRILY-QNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT 3506
E EK+E+ R + Q L S R R+ L+Q +E KE
Sbjct: 568 KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ-LEALEKEK------------- 613
Query: 3507 GCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTG 3566
+LE+++Q+LQ VA++ + Q + + Q E A+ + ++E+ ++
Sbjct: 614 --AAKLEILQQQLQ-VANEARDSAQTSVTQAQREKAE------LSRKVEELQACVETARQ 664
Query: 3567 QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3621
+Q E + V+ E LR + ++ +EK+ L+ + L+E ++
Sbjct: 665 EQHEAQAQVAE-------LELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLK 712
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 162 bits (409), Expect = 8e-39
Identities = 259/1287 (20%), Positives = 555/1287 (43%), Gaps = 201/1287 (15%)
Query: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQ----LQEFEAAIKQ 202
EQ A T + ++S+ ++ E RE E +VT TE L + +Q+ + + Q
Sbjct: 162 EQKAAQLATEIADIKSK-----YDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQ 216
Query: 203 RDGI--ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTA 260
R GI + L L Q + D LE +S+KL+ + ++LQ+ +T S
Sbjct: 217 RPGIEDVAVLKKELVQVQTLMDNMT---LERERESEKLKDECKKLQSQYASSEATISQLR 273
Query: 261 ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSN 320
++L + Q++ + Q+L++ + + +K + T + L+++ ++E+ E+ +
Sbjct: 274 SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL--LKKEQDYTKLEEKHNEESVS 331
Query: 321 KEEIQ----EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376
K+ IQ +K+ ++L +++ E + +L+ + +L+E++ + + +++
Sbjct: 332 KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391
Query: 377 KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE 436
K E +Q+ + + QL + +L + + + + R++++ Q E+L +
Sbjct: 392 KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451
Query: 437 LDEMYGQQIV------QMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL 490
++ Q+ Q+K+++ Q + KT+ + + + AL+ + + E Q L
Sbjct: 452 EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL 511
Query: 491 MNVA--INELNIKLQDTNSQKEKLKEELGLILEEK------------------------C 524
V I + + K+Q+ + +K KE + L+ +E+
Sbjct: 512 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNH 571
Query: 525 ALQRQLEDLVEELSFSREQIQRARQTIAEQ------------------ESKLNEAHKSLS 566
LQ Q+ L E+L E ++A++ + +Q E+ +NE + L+
Sbjct: 572 TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN 631
Query: 567 TVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM-LEKEKNAVLDRMAESQEAELERL 625
++ +++ +++ EL L EA T + L+ L+ +NA+ D+ + EL ++
Sbjct: 632 ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK-----QQELNKI 686
Query: 626 RTQL------LFSHEEELSKLKEDLEI--EHRINIEKLKDNL-GIHYKQQIDGLQNEMSQ 676
TQL L +E S+L+ L+ E +++E+ + L G K + D L+ + S+
Sbjct: 687 TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 746
Query: 677 KIETMQFEKDNLITKQNQL-ILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEE 735
+ ++ + +L E+SK ++++ +V+S ++ + L+ + L ++E
Sbjct: 747 EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE 806
Query: 736 KEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHT 795
+EK L+Q+ + L +T++ +++ + + +++ E L E T++D L +
Sbjct: 807 EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL---S 863
Query: 796 PVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEK 855
VS DS+K+ S +EKE + DL++ C +L +++ Q
Sbjct: 864 KVS--------DSLKNSK--SEFEKENQKGKAAILDLEKTCKELKHQLQVQ--------- 904
Query: 856 NFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSS 915
E +E +E +K LE K + K +L ++ E+L +Q N T+K
Sbjct: 905 -MENTLKEQKE-------LKKSLEKEKEASH-QLKLELNSMQEQL-IQAQN--TLKQNEK 952
Query: 916 VFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISF 975
+ + + E + E +K L +L++ +K EL + L +QL Q E++
Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK---LQQQLTQAAQELAA 1009
Query: 976 LNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSV 1035
E++ L+ E+ ++L+ +E + + L V S E +
Sbjct: 1010 EKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD-----LKSVEEKLSLAQEDLI 1064
Query: 1036 SKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL--ILDHLPSVTKESSLRATQPSEND 1093
S N+ G ++K++ E K + + K++QL L + KE SL+
Sbjct: 1065 SNRNQ-IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK-------- 1115
Query: 1094 KLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFA 1153
+KEL KS+ ++ E ++ ++K + L EEL
Sbjct: 1116 --EKELVNEKSKLAEI-----------------------EEIKCRQEKEITKLNEELKSH 1150
Query: 1154 QEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEY 1213
+ E IKE+ + + Q + Q+ +GK L+ AV +E +
Sbjct: 1151 KLESIKEITNLKDAK-QLLIQQKLELQGK-----ADSLKAAVEQE-------------KR 1191
Query: 1214 YTPALKCEVNAEDKENSGDYISENE--DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL 1271
LK +V E++E ++I + E+++ ++ +EN L ++T L
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL- 1250
Query: 1272 VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDL 1331
+ K W + + + + E + + ++ LE N++ + +L L
Sbjct: 1251 ---GTVKKEW---------QSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL--L 1296
Query: 1332 EK-TKLEEQVQELESLISSLQQQLKET 1357
E+ K E ++++L++ + LQ++L T
Sbjct: 1297 ERCLKGEGEIEKLQTKVLELQRKLDNT 1323
Score = 158 bits (399), Expect = 1e-37
Identities = 249/1160 (21%), Positives = 479/1160 (41%), Gaps = 170/1160 (14%)
Query: 1856 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915
K EA+ + + H + L R+ ++ + L+ L EE E+L
Sbjct: 58 KHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQAS------LKEEKWYSEELKK 111
Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
EL K +G+ ++Q + ++ EL +L+E + E I++ ++L
Sbjct: 112 ELEKYQGL-----------QQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDL 160
Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
++ + E ++ + + E+ ++E E + ++ ++L K+ +
Sbjct: 161 FEQKAAQLATEIADIKSKY--DEERSLREAAEQK--VTRLTEELNKEATVI--------- 207
Query: 2036 RFIELEQEKNTELMDLR--QQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ 2093
Q+ TEL+ + L+K+L +++ +D ++RE E + + E +KL+ Q
Sbjct: 208 ------QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261
Query: 2094 --------------LKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDI 2139
L P+ + + ++++ N L +K +E LL KEQ +
Sbjct: 262 YASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKL 321
Query: 2140 QERNEE-----------IEKLEFRVRELEQALLVSADTFQKVE---DRKHFGAVEAKPEL 2185
+E++ E + + + ++L+ L S + ++ K + K EL
Sbjct: 322 EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL 381
Query: 2186 S--------LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
S L+ + + + + KE+ L+ ++ Q +L ++ + H +L+ Q+
Sbjct: 382 SEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 441
Query: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV----E 2293
+ S+ +L + EQ+ + + +L +KE ST+ QH L K Q QE++
Sbjct: 442 QLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL-DKTKQQHQEQQALQQST 500
Query: 2294 IDQLNEQVTKLQQQL--------KITTDNKVIEEKNELIRDLETQIECLMS------DQE 2339
+L E L+Q L KI ++++ E I LE + E L + +
Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560
Query: 2340 CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2399
V +E+ L E + +L ++L N + +L ++ K L L+LE
Sbjct: 561 AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620
Query: 2400 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLK----RERESVEKIQSIPENSVNVAI 2455
V N ++ K + + + ++ T+ L S + +R ++ +N++
Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680
Query: 2456 DHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTV---SAKD 2512
L+K +L+ V T E+ + +S + K ++LE + +LE + A
Sbjct: 681 QELNKITTQLDQV-TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 2513 LELTQCYKQ-IKDMQEQGQFETEM------------LQKKIVNLQKIVEEKVAAALVSQI 2559
LE+ +Q ++D+Q+Q Q T++ ++K+IV+ ++ +K + AL S
Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
Query: 2560 QLEAVQEYAK--FCQDNQTISSEP--ERTNIQNLNQLREDELGS---DISALTLRISELE 2612
Q QE K QD +T+S E + + N Q EL + AL +S ++
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 2613 SQVVEMHTSLILEKEQVEIAEKN----VLEKEKKLLELQKLL----------EGNEKKQR 2658
++ ++ SL K + E + +L+ EK EL+ L + KK
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919
Query: 2659 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELAS--YKEKAEKLQ 2716
EKEK+ S Q L + E + + NE E + + + + +S K++ E LQ
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979
Query: 2717 EELLVKETNMT----SLQKDLSQVRDHLAEAKEKLSIL----EKEDETEVQ--------E 2760
EL + T LQ+ L+Q LA KEK+S+L EK ET Q E
Sbjct: 980 GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039
Query: 2761 SKKACMFEPLPIKLSKSIASQTD---GTLKISSSNQTPQILVKNAGIQINLQSECSSEEV 2817
S+ + L K +Q D +I + N+ Q L K A + Q E+
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL-KTAKATLE-QDSAKKEQQ 1097
Query: 2818 TEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQC 2877
+ + + I+K + L E+++ +S+ ++E E +K + L EE
Sbjct: 1098 LQERCKALQDIQKEKSLKEKELVNEKSK-LAEIEEIKCRQEKEITKLNEE---------- 1146
Query: 2878 LRSKEGSSIPELAH-SDAYQ 2896
L+S + SI E+ + DA Q
Sbjct: 1147 LKSHKLESIKEITNLKDAKQ 1166
Score = 145 bits (365), Expect = 1e-33
Identities = 237/1166 (20%), Positives = 492/1166 (42%), Gaps = 155/1166 (13%)
Query: 321 KEEIQEKETIIEELNTKIIEEEKKTLELKDKL-----------TTADKLLGELQEQIVQK 369
++E+Q+ + ++E EE KK LE L T + L L++Q+ +
Sbjct: 89 RQEVQDLQASLKE-EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
Query: 370 NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
E N+K +QK Q + EI + +E + Q T + + + +E
Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA-TV 206
Query: 430 LEQLRAELDEMYG-QQIVQMKQELIRQHMAQMEEMKTRHKGEME---------------- 472
++ L+ EL + G + + +K+EL+ Q M+ M + E E
Sbjct: 207 IQDLKTELLQRPGIEDVAVLKKELV-QVQTLMDNMTLERERESEKLKDECKKLQSQYASS 265
Query: 473 ----NALRSY-----SNITVNEDQIKLMNVAINELN-----------------IKLQDTN 506
+ LRS + V +++ + ++NEL KL++ +
Sbjct: 266 EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325
Query: 507 SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLS 566
+++ K+ + L +K + L LS S + R ++E+ + + LS
Sbjct: 326 NEESVSKKNIQATLHQK---DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382
Query: 567 TVE----DLKAEIVSASESRKELE---LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619
VE LKAE + R+E E L+ ++E+ KL E++ R+ E ++
Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442
Query: 620 AELERL--RTQLLFSHEEELSKLKEDL--------EIEHRINIEKLKDNLGIHYKQQIDG 669
E+L + Q + + +LS+L+E L E++H+++ K + H +QQ
Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ-----HQEQQ--A 495
Query: 670 LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ------SLVNSKSEEMTLQINE 723
LQ + K+ Q + + ++ + +I L+ L Q SL+ + E++ +I
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
+ E +L Q +++ TL+++V +L K + + K+ + +L ++ + +A +D
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 784 KKTLEDML-KIHTPVSQEERLIFLDSIKSKSKDSV------------------WEKEIEI 824
+LE + ++++ +++ + + I+ K+K + +
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 825 LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884
L ++ ++L + QL++ K ++ + E + +E +E+Y L + ++LE K
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQ-LESHLKEYKEKYLSLEQKTEELEGQIKK 734
Query: 885 QE---LEYKSKLKALNEELHLQRINPTTVKMK----SSVFDEDKTFVAETLEMGEVVEKD 937
E LE K+ + ++L QR T ++++ S + +K V+ T + +
Sbjct: 735 LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794
Query: 938 TTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE----ISFLNEEVKSLKQEKE----- 988
+ +KL + EK L Q LS++ K +H E I E++ +K EKE
Sbjct: 795 LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE 854
Query: 989 --QVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVN--KSFGE 1044
V + ++ + ++++E + +++LD T + V N K E
Sbjct: 855 LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE 914
Query: 1045 ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104
K + ++K + + + S QEQLI +++L+ + E +LQ +N LK
Sbjct: 915 LKKSLEKEKEASHQLKLELNSMQEQLI-------QAQNTLKQNE-KEEQQLQGNINELKQ 966
Query: 1105 EQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI 1164
+ Q+EA + L + + +EN+ + L +EL A++EKI LQ
Sbjct: 967 SSEQKKKQIEALQGELKIAVLQKTE-----LENKLQQQLTQAAQELA-AEKEKISVLQNN 1020
Query: 1165 HQLELQTMKTQETGDEGKPLHLLIGKLQ-KAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
++ +T K ++ G+ LL + K+V E+ S + L S + K
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN-KLIQE 1079
Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283
+ + + + S ++ +LQ+ +QD Q+ ++ E +KL ++ + Q
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR---Q 1136
Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQ---V 1340
+ + KL E L + E + + + + + + + K +L D K +E++
Sbjct: 1137 EKEITKL---NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQ 1193
Query: 1341 QELESLISSLQQQLKETEQNYEAEIH 1366
Q L+ + +++LK+ EA++H
Sbjct: 1194 QILKDQVKKEEEELKKEFIEKEAKLH 1219
Score = 141 bits (355), Expect = 1e-32
Identities = 289/1385 (20%), Positives = 573/1385 (41%), Gaps = 232/1385 (16%)
Query: 1135 MENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKA 1194
+ E SLKEE +++E K KEL+K L+ Q E KP L+
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELK-KELEKYQGLQQQ---------EAKPDGLVT------ 131
Query: 1195 VSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQE 1254
+ S LQ+L L E T + + E ++ E +++ E + +E
Sbjct: 132 ---DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLA-TEIADIKSKYDEERSLRE 187
Query: 1255 NMHTLLNKVTEEYNK-LLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313
+ ++TEE NK V+Q +++ + G E++ + E + + + M N
Sbjct: 188 AAEQKVTRLTEELNKEATVIQDLKTELLQRP--------GIEDVAVLKKELVQVQTLMDN 239
Query: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQ 1373
+ + + + L+D E KL+ Q E+ IS L+ +L + Q + LQK
Sbjct: 240 MT---LERERESEKLKD-ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS 295
Query: 1374 AVSESTVPPSLPVDSVVITESD---AQRTMYPGSCVKKNIDGTI--------EFSGEFGV 1422
+V+E T ++++ E D + S KKNI T+ +
Sbjct: 296 SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355
Query: 1423 KEETNI----VKLLEK-QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKEN-----TA 1472
E T++ V+L EK + ++L+EE+++V A+ +L + KE +
Sbjct: 356 SE-TSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 414
Query: 1473 SSKQAHAVCQQEQHYFNEM--------KLSQDQIGFQTFETVDVKFK-----EEFKP--- 1516
Q H+ + + E +LS +++ + + D++ K E+ K
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474
Query: 1517 --------LSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSI--H 1566
L K +H ++ L S + E+++ + + ++ KD+ +++
Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534
Query: 1567 DEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE-----HQQATELLRQAHMRQMERQRE 1621
+ ++S ++ R+ + + Q + ++ Q QE +Q T+L + Q E ++
Sbjct: 535 SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK-NQSESHKQ 593
Query: 1622 DQEQLQEEIKRLNRQL--AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
QE L ++++ L AQ + E V+E L E E + QL + + K L
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653
Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVV 1739
+ +T + Q L + ALQ L KI ++
Sbjct: 654 AEAAKTAQRADLQNH----------------------LDTAQNALQDKQQELNKITTQLD 691
Query: 1740 KTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE---EHTRVTDESIP 1796
+ TA +++ + SQ + L E S++ E + ++ +S+
Sbjct: 692 QVTAKLQDK----------QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 1797 SYSGSDMPRNDINMWSKVTEE----GTELSQRLV--RSGFAGTEIDPENE-ELMLNISSR 1849
+ + D+ ++ + TELS++L + + T +D + + E + +I +
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
Query: 1850 L--QAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES 1907
L Q +++L+ ET SQ +T++ E + + T + EL++ E+
Sbjct: 802 LTKQEEEKQILKQDFETLSQ-------ETKIQHEELNNRIQTTVT-----ELQKVKMEKE 849
Query: 1908 RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ-ELEAEQ 1966
+L+ K V D + K+ FE++ Q+ I LE+ ++LQ ++E
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 1967 QQIQEERELLSRQKEA---MKAEAGPVEQQLLQETEKLMK-EKLEVQCQA-----EKVRD 2017
++ +E ++ L ++KEA +K E +++QL+Q L + EK E Q Q ++ +
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969
Query: 2018 DLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA-------LEKQLEKMR---K 2067
+KQ++AL+ +++ V + ELE + +L Q+ A L+ EK + K
Sbjct: 970 QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFK 1029
Query: 2068 FLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
L RE E +Q+++ +E++L + ++ N + + E
Sbjct: 1030 QLQSDFYGRESELLATRQDLKSVEEKLSLAQE----------DLISNRNQIGNQNKLIQE 1079
Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSL 2187
L +K L++D ++ +++++ R + L+ QK + K V K +L+
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQE---RCKALQD--------IQKEKSLKEKELVNEKSKLAE 1128
Query: 2188 EVQLQAERDAIDRKEKEITNLEEQLEQFR----EELENKNEEVQQLHMQ-LEIQKKESTT 2242
+++ R+EKEIT L E+L+ + +E+ N + Q L Q LE+Q K +
Sbjct: 1129 IEEIKC------RQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182
Query: 2243 R--LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2300
+ +++ ++ ++ KD ++K +K+ H I+EKEV + + E
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH-------SEIKEKEVGMKKHEEN 1235
Query: 2301 VTKLQQQLKITTDN-----KVIEEKNELIRDLETQIECLMSD----QECVKRNREE---- 2347
KL Q+ +N K + + +LE Q + L + + V+ N++E
Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295
Query: 2348 ---------EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2398
EIE+L + +LQ++L N T+ L E SL+ + + K A
Sbjct: 1296 LERCLKGEGEIEKLQTKVLELQRKLDN----TTAAVQELGRENQSLQIKHTQALNRKWAE 1351
Query: 2399 EQQVE 2403
+ +V+
Sbjct: 1352 DNEVQ 1356
Score = 139 bits (351), Expect = 4e-32
Identities = 277/1403 (19%), Positives = 610/1403 (43%), Gaps = 217/1403 (15%)
Query: 479 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEEL--------------GLILEEKC 524
SN+ + D + L+ + +L L++ E+LK+EL GL+ +
Sbjct: 76 SNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSA 135
Query: 525 ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE---S 581
LQ LE +EE I++ + ++ ++L + + D + + A+E +
Sbjct: 136 ELQ-SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 582 RKELELKHEAEVTNYKIKLEMLEK---EKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638
R EL EA V +K E+L++ E AVL + + +++ L + E E
Sbjct: 195 RLTEELNKEATVIQ-DLKTELLQRPGIEDVAVL----KKELVQVQTLMDNMTLERERESE 249
Query: 639 KLKEDLE------IEHRINIEKLKDNLG---------IHYKQQIDGLQNEMSQKIETMQF 683
KLK++ + I +L+ L + Q++ NE++QK +T+
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL-- 307
Query: 684 EKDNLITKQNQLILEISKLKDL-QQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 742
+NL+ K+ + +KL++ + V+ K+ + TL +L + ++ + + +L
Sbjct: 308 -TENLLKKEQ----DYTKLEEKHNEESVSKKNIQATLHQKDLDCQ-QLQSRLSASETSLH 361
Query: 743 QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE--------DMLKIH 794
+ EL K E +K +KE+ ++++ K+ L+AE L+ +++ E ++ ++H
Sbjct: 362 RIHVELSEKGEATQK-LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
Query: 795 TPVSQEERLI-----FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 849
+ + + ER + L + S + + +KE ++ DL+ + +L E+++++
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQV-----ADLQLKLSRLEEQLKEKVTN 475
Query: 850 FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTT 909
+ + + Q+ QE+ A L +++N E + + +++ +Q +
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR---QIGDKDQKIQNLEALL 532
Query: 910 VKMKS--SVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLK 967
K K S+ ++++ + ++ GE +L EK + + +L+++L + SE K
Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592
Query: 968 QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027
Q L+++V ++++ LR + + V S +T V+ L
Sbjct: 593 QAQEN---LHDQV-----QEQKAHLRAAQ----------DRVLSLETSVNEL-------- 626
Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT 1087
S++N+S + S++ ++ K E + E +K Q ++ L
Sbjct: 627 -------NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ-------RADLQNHLDTA 672
Query: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147
Q + DK Q+ELN + ++ + + +++ ++ H Q+ +++ K+K L
Sbjct: 673 QNALQDK-QQELNKITTQLDQVTAKLQDKQ--------EHCSQLESHLKEYKEKYLS--L 721
Query: 1148 EELIFAQEEKIKELQKIHQLELQTMKTQETGD------EGKPLHLLIGKLQKAVSEECSY 1201
E+ E +IK+L+ LE++ K Q D L L +L K + E
Sbjct: 722 EQKTEELEGQIKKLE-ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780
Query: 1202 FLQTLCSVLGEYYT-PALKCEVNAEDKEN---SGDYISENEDPELQDYRYEVQDFQENMH 1257
T + + ++K ++ +++E D+ + +++ ++Q E+ + +
Sbjct: 781 VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ--HEELNNRIQTTV 838
Query: 1258 TLLNKVTEEYNKLL----VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313
T L KV E L+ ++ +LSK+ K EF +EN K + L +
Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKV-SDSLKNSKSEFEKEN-QKGKAAILDLEKTCKE 896
Query: 1314 LE-DIDVNHKSKLSSLQDLEKT--KLEEQVQELESLISSLQQQL---KETEQNYEAEIHC 1367
L+ + V ++ L ++L+K+ K +E +L+ ++S+Q+QL + T + E E
Sbjct: 897 LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 1368 LQKRLQAVSESTVPPSLPVDSV--VITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425
LQ + + +S+ ++++ + + Q+T ++ E + E KE+
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE---KEK 1013
Query: 1426 TNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQ 1485
++++ ++ QE ++ + S A + +L + E S Q + + Q
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV----EEKLSLAQEDLISNRNQ 1069
Query: 1486 HYFNEMKLSQD-QIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDC 1544
N+ KL Q+ + T E K +++ + K L + KE L ++ K
Sbjct: 1070 -IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEK---ELVNEKSK 1125
Query: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQA 1604
+ I E ++K +++E+ +++ +++ L+D +Q L++Q E Q
Sbjct: 1126 LAEIEEIKCRQEKEI---TKLNEELKSHKLESIKEI----TNLKDAKQLLIQQKLELQGK 1178
Query: 1605 TELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALK 1664
+ L+ A +E+++ +Q+ L++++K+ +L + E+E L E++ K
Sbjct: 1179 ADSLKAA----VEQEKRNQQILKDQVKKEEEELKKE--------FIEKEAKLHSEIKE-K 1225
Query: 1665 QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ----TFKEKELDRKPEDVPPEIL--- 1717
++ + E+ +L T NEN G V+++ + EL+++ +D+ EI
Sbjct: 1226 EVGMKKHEENEAKLTMQITAL---NENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282
Query: 1718 ------SNERYAL-----------QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
+ER AL +K ++L++ ++ TTAAV+E LG ++S
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQE------LGRENQS 1336
Query: 1761 SKSQSSASLIWRSEAEASVKSCV 1783
+ + + +L + + V++C+
Sbjct: 1337 LQIKHTQALNRKWAEDNEVQNCM 1359
Score = 139 bits (350), Expect = 6e-32
Identities = 258/1338 (19%), Positives = 559/1338 (41%), Gaps = 183/1338 (13%)
Query: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2268
E L R+++ +EVQ L L+ +K S +ELE+ L + + + GL S
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 2269 DAMSTQDQHV---------------LFGKFAQIIQEKEVEIDQLNEQVTKLQQ--QLKIT 2311
+ + +Q + LF + A + + +I ++ L++ + K+T
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 2312 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2371
+ + ++ +I+DL+T E ++R E++ L + + ++Q + N+ +
Sbjct: 195 RLTEELNKEATVIQDLKT---------ELLQRPGIEDVAVLKKELVQVQTLMDNMTLERE 245
Query: 2372 MNAHSLSEEADSLKHQ-------LDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424
+ L +E L+ Q + + +E Q+V +E+ +K+ + E K
Sbjct: 246 RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQ 305
Query: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484
LT+ L LK+E++ + + E SV+ + + +L+ + L + E +
Sbjct: 306 TLTENL--LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI 363
Query: 2485 SFEENGKGSII-NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQG---QFETEMLQKKI 2540
E + KG L+ L ++E+ E Q +Q ++ ++ G Q E L K+
Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
Query: 2541 VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSD 2600
+ ++ + E L Q QL + + + E + ++Q E++L
Sbjct: 424 LETERQLGE-AHGRLKEQRQLSS----------EKLMDKEQQVADLQLKLSRLEEQLKEK 472
Query: 2601 ISALTLRISEL--------ESQVVEMHTSLILEKEQVEIAE--KNVLEKEKKLLELQKLL 2650
++ T +L E Q ++ T+ L + Q ++ + + + +K++K+ L+ LL
Sbjct: 473 VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
Query: 2651 EGNEKKQREKEKKR---------SPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2701
+ +++ EK+R + VL E H+ +E E L+ +S +
Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ-VTQLTEKLKNQSESH 591
Query: 2702 KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2761
K + ++ ++ + L + + SL+ ++++ L E+KEK+S L+ + + + +
Sbjct: 592 KQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE-- 649
Query: 2762 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEII 2821
L + A++T + + T Q +++ ++N ++T +
Sbjct: 650 -----------LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN--------KITTQL 690
Query: 2822 SQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR-- 2879
Q T K++ QE H S+ E+ +E+ L+++ L+ I+ L
Sbjct: 691 DQVTAKLQDKQE------------HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738
Query: 2880 SKEGSSIPELAHSDAYQTR------EICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2933
S E + E A D Q R E+ +++ + S D+ + ES
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 2934 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISS 2993
+ ++ K +L+ Q + ++ ++ ++ + + E++A + +S+
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM-EKEALMTELST 857
Query: 2994 LKDLITKMQLQREAEVYDSSQSHESFSDWRGE-LLLALQQVFLEERSVLLAAFRTELTAL 3052
+KD ++K+ ++ +S+S + +G+ +L L++ E + L + E T
Sbjct: 858 VKDKLSKV-----SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL--QVQMENTLK 910
Query: 3053 GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQ 3112
+ L ++ + +E + E L +A ++ L + + Q+ G LK+
Sbjct: 911 EQKELKKSLEKEKEASHQLKLELNSMQEQLIQA--QNTLKQNEKEEQQLQGNINELKQSS 968
Query: 3113 ESEKPSQELLEYNIQ-----------QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV 3161
E +K E L+ ++ + Q Q+ + EL++ K++ + LQ +
Sbjct: 969 EQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETF 1028
Query: 3162 AEL-------KSELAQTKLELETT-----------------LKAQHKHLKELEAFRLEVK 3197
+L +SEL T+ +L++ + Q+K ++EL+ + ++
Sbjct: 1029 KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088
Query: 3198 D----KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE---RDKEELEDLKFSLE 3250
K ++ L QK+ + L EK+KL EE R ++E+ L L+
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK 1148
Query: 3251 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIR 3310
S K +++ L+ KQLL QQK+E Q + + EQ + + Q+L + K
Sbjct: 1149 SHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAAVEQEKRNQ-QILKDQVKKEEE 1205
Query: 3311 EMSST-LDRERELHAQLQSSDGTGQSRPPLPSEDL----------LKELQKQLEEKHSRI 3359
E+ +++E +LH++++ + G + L L ++K+ + R+
Sbjct: 1206 ELKKEFIEKEAKLHSEIKEKE-VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264
Query: 3360 VELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQL 3419
EL +T+ + + ++ ++ R L E +G+ ++ +LQ+KV +LQR+L
Sbjct: 1265 SELEKQTDDLRGEIAVLEATVQNNQDERRALL----ERCLKGEGEIEKLQTKVLELQRKL 1320
Query: 3420 EEKRQQVYKLDLEGQRLQ 3437
+ V +L E Q LQ
Sbjct: 1321 DNTTAAVQELGRENQSLQ 1338
Score = 116 bits (290), Expect = 5e-25
Identities = 269/1358 (19%), Positives = 571/1358 (42%), Gaps = 197/1358 (14%)
Query: 864 LQEEYACLLKVKDDLEDSKNKQELEYK---------SKLKALNEELHLQRINPTTVKMKS 914
L+EE ++K +LE + Q+ E K ++L++L ++L + +K
Sbjct: 99 LKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMK 158
Query: 915 SVFDEDKTFVA-----------ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963
+F++ +A E + E E+ T L E+L + + + DL
Sbjct: 159 DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELN-------KEATVIQDLK 211
Query: 964 EQLKQKHG--EISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
+L Q+ G +++ L +E+ ++ + ++L RE E + + +QS Q +S
Sbjct: 212 TELLQRPGIEDVAVLKKELVQVQTLMDNMTLE-RERESEKLKDECKKLQS---QYASSEA 267
Query: 1022 GVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKE 1081
+ + S A+G +E + V++ ++ +V E +++ Q + ++L + KE
Sbjct: 268 TISQLRSELAKGP---------QEVAVYVQELQKLKS-SVNELTQKNQTLTENL--LKKE 315
Query: 1082 SSLRATQPSENDKLQKELNVLKS-EQNDLRLQMEAQRICLS--LVYSTHVDQVREYMENE 1138
+ N++ + N+ + Q DL Q R+ S ++ HV+ +E
Sbjct: 316 QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL------SE 369
Query: 1139 KDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE 1198
K +A LKEEL + K L+ + + Q+ +E K H L +LQ +++
Sbjct: 370 KGEATQKLKEELSEVET-------KYQHLKAEFKQLQQQREE-KEQHGL--QLQSEINQL 419
Query: 1199 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258
S L+T LGE + LK E ++ S + +L D +V D Q +
Sbjct: 420 HSKLLETERQ-LGEAHG-RLK-----EQRQLSSE--------KLMDKEQQVADLQLKLSR 464
Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQ--------QTDGMKLEFGEENLPKEETEFLSIHSQ 1310
L ++ E+ LQ +L K Q Q+ KL + +L + + +
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524
Query: 1311 MTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQK 1370
+ NLE + K +S L+ E+ L ++Q E + L Q L+E + ++ L +
Sbjct: 525 IQNLEALLQKSKENISLLEK-EREDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQVTQLTE 582
Query: 1371 RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG-VKEETNIV 1429
+L+ SES + V + R D + + + N
Sbjct: 583 KLKNQSESHKQAQENLHDQVQEQKAHLRAAQ---------DRVLSLETSVNELNSQLNES 633
Query: 1430 KLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFN 1489
K Q Q++ + ++ + + AQ+ +L +N KQ Q
Sbjct: 634 KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693
Query: 1490 EMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTIS 1549
KL Q E+ ++KE++ L ++ E +I +D ++ SK+ L
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753
Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609
++ ++ ++ ++ + + + S+QL + +E + R +L Q+ +A E ++
Sbjct: 754 QQ----------QRQLNTDLELRATELSKQLEMEKEIVSSTRLDL----QKKSEALESIK 799
Query: 1610 QAHMRQMERQ---REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666
Q +Q E + ++D E L +E K + +L R + V+E ++V +E+ + +L
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI----QTTVTELQKVKMEKEALMTEL 855
Query: 1667 SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK 1726
S ++KL + + + ++++ E E Q K LD L+K
Sbjct: 856 STV-KDKL-----SKVSDSLKNSKSEFEKENQKGKAAILD-----------------LEK 892
Query: 1727 ANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE 1786
L L ++ T ++ L +S + + AS + E + + + +
Sbjct: 893 TCKELKHQLQVQMENTLKEQKE--------LKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944
Query: 1787 HTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQ-RLVRSGFAGTEIDPENEELMLN 1845
+T +E ++ N++ S+ ++ E Q L + TE++ + ++ +
Sbjct: 945 NTLKQNEKEEQQLQGNI--NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
Query: 1846 ISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE---ATESLKCQEELRER 1902
+ L A EK IS + E ++ T +L + + ++ E + LK EE
Sbjct: 1003 AAQELAAEKEK----ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1058
Query: 1903 LHEESRA-------REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRL------- 1948
E+ + + +L EL A+ ++ + +K E+Q+QE+ + +
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK---EQQLQERCKALQDIQKEKSLK 1115
Query: 1949 EQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV 2008
E+EL+ ++L E+E + + ++E L+ + ++ K E+ L + L+++KLE+
Sbjct: 1116 EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175
Query: 2009 QCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKF 2068
Q +A+ ++ ++++ + +I +++QV + E+E+ + + +EK+ + +
Sbjct: 1176 QGKADSLKAAVEQEKRNQQI-LKDQVKK----EEEE--------LKKEFIEKEAKLHSEI 1222
Query: 2069 LDEQAIDREHERD--VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126
+++ ++HE + +I L + L V + S+ + E+E+ + L+ +
Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282
Query: 2127 ELLLSKEQLQRDIQER----NEEIEKLEFRVRELEQAL 2160
+ + + +R + ER EIEKL+ +V EL++ L
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320
Score = 108 bits (270), Expect = 1e-22
Identities = 244/1245 (19%), Positives = 512/1245 (41%), Gaps = 184/1245 (14%)
Query: 2505 ESTVSAKDLELTQCYKQIKDMQ---EQGQFETEMLQKKIVNLQKIVEEKVAA-ALVSQIQ 2560
ES ++ K ++T ++++D+Q ++ ++ +E L+K++ Q + +++ LV+
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 2561 LEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED---ELGSDISALTLRISE------- 2610
E +Q + ++ QT E NI+ + L E +L ++I+ + + E
Sbjct: 135 AE-LQSLEQQLEEAQT-----ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 2611 LESQVVEMHTSLILEKEQVEIAEKNVLEK---------EKKLLELQKLLEGNEKKQREKE 2661
E +V + L E ++ + +L++ +K+L+++Q L++ N +RE+E
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMD-NMTLERERE 247
Query: 2662 KKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL- 2720
++ + + L++ + S+E + + LR+E E+A Y ++ +KL+ +
Sbjct: 248 SEKLKDECKKLQSQ---YASSEAT-----ISQLRSELAKGPQEVAVYVQELQKLKSSVNE 299
Query: 2721 VKETNMTSLQKDLSQVRDH--LAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSI 2778
+ + N T + L + +D+ L E + S+ +K + + + C + L +LS S
Sbjct: 300 LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC--QQLQSRLSASE 357
Query: 2779 ASQTDGTLKISSSNQTPQIL-------------VKNAGIQINLQSECSSE-------EVT 2818
S +++S + Q L +K Q+ Q E + E+
Sbjct: 358 TSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN 417
Query: 2819 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2878
++ S+ E ++ E H E R +S + + +E VA LK L + + L
Sbjct: 418 QLHSKLLETERQLGEAHGRL---KEQRQLSSEKLMDKEQQVADLQLK-----LSRLEEQL 469
Query: 2879 RSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF---DIASEGRGEESESA 2935
+ K +S EL H +T++ L +Q + G ++
Sbjct: 470 KEKVTNST-ELQHQ-LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
Query: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEP--WLEERKAYINTISS 2993
++ +K K + + E + + ++ +GE + Q+ E L+E+
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQA--GEGETAVLNQLQEKNHTLQEQ--------- 576
Query: 2994 LKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALG 3053
+ L K++ Q E+ H+ + + L A +V E SV EL +
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV------NELNSQ- 629
Query: 3054 TTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQE 3113
LN ++++ + ++ +A E L A+ + + ++QE
Sbjct: 630 -------LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
Query: 3114 SEKPSQEL--LEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3171
K + +L + +Q KQ +++ L K++ L+++ + + +L+++ +
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
Query: 3172 KLELETTLK--AQHKHLK---ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK 3226
K E L+ Q + L EL A L K E +++ T QKKS ALE
Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELS-KQLEMEKEIVSSTRLDLQKKSE----ALES 797
Query: 3227 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3286
K KL + E EE + LK E+ Q + + E+ + + +++ +M +A
Sbjct: 798 IKQKLTKQE----EEKQILKQDFETLSQ---ETKIQHEELNNRIQTTVTELQKVKMEKEA 850
Query: 3287 QLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK 3346
++E L + K ++ ++S +L + ++ + + G++ L E K
Sbjct: 851 LMTE-----------LSTVKDKLSKVSDSLKNSK---SEFEKENQKGKA-AILDLEKTCK 895
Query: 3347 ELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMH 3406
EL+ QL+ + ++ E +K + Q++ + ++ L Q + +K+
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Query: 3407 ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3466
+LQ + +L++ E+K++Q+ + LQG ++ Q+ E E K L Q L +
Sbjct: 956 QLQGNINELKQSSEQKKKQI-------EALQGELKIAVLQKTELENK------LQQQLTQ 1002
Query: 3467 PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKL 3526
L +++ + VLQ E + ++ G EL RQ L+ V KL
Sbjct: 1003 -AAQELAAEKEKISVLQNNY-----EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056
Query: 3527 QVLPQ-------------KASERLQFETAD-DEDFIWVQENIDEIILQLQKLTGQQG-EE 3571
+ + K + L+ A ++D ++ + E LQ + ++ +E
Sbjct: 1057 SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE 1116
Query: 3572 PSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3631
LV+ + + E RQ E+T +L K + + L++ + Q
Sbjct: 1117 KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQ------ 1170
Query: 3632 NSSRFSLNGGA-NIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK 3675
+ L G A +++A + EK R + L+ +K+ E E+ K
Sbjct: 1171 --QKLELQGKADSLKAAVEQEK----RNQQILKDQVKKEEEELKK 1209
Score = 96.3 bits (238), Expect = 5e-19
Identities = 166/762 (21%), Positives = 316/762 (41%), Gaps = 117/762 (15%)
Query: 2975 QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF 3034
Q E LEE + I +KDL + Q E+ D ++
Sbjct: 138 QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD----------------- 180
Query: 3035 LEERSVLLAAFR--TELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS 3092
EERS+ AA + T LT +A + + + +Q G+E A + + L
Sbjct: 181 -EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL--------KKELV 231
Query: 3093 EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQE 3152
++Q L M TL+RE+ESEK E ++ QSQ + +S ++ + +
Sbjct: 232 QVQTLMDNM-----TLERERESEKLKDEC-----KKLQSQYASSEATISQLRSELAKGPQ 281
Query: 3153 QLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN--DTL 3210
+++ + +LKS + + + +T + K KE + +LE K + V N TL
Sbjct: 282 EVAVYVQELQKLKSSVNELTQKNQTLTENLLK--KEQDYTKLEEKHNEESVSKKNIQATL 339
Query: 3211 ASEQKKSRELQWALEKEKAKL----------GRSEERDKEELEDLKFSLESQKQRNLQLN 3260
+ ++LQ L + L G + ++ KEEL +++ + K QL
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 3261 LLLEQQKQ---LLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317
E+++Q L ++ S+ + + QL E GR L+ Q L SEK+ +D
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGR-LKEQRQLSSEKL--------MD 450
Query: 3318 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR 3377
+E+++ A LQ L L++QL+EK + EL ++ +K T+
Sbjct: 451 KEQQV-ADLQLK---------------LSRLEEQLKEKVTNSTELQHQLDK-------TK 487
Query: 3378 QQMEKDRQVHRKTLQTEQEANTEGQKKMHEL---QSKVEDLQRQLEEKRQQVYKLDLEGQ 3434
QQ ++ + + + T +EA + ++ + ++ K+++L+ L++ ++ + L+ E +
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
Query: 3435 RLQGIMQEFQKQELEREEKRESRRILYQNL--------NEPTTWSLTSDRTRNWVLQQKI 3486
L +Q + + + +E L + + N+ + + + V +QK
Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKA 607
Query: 3487 EGETKESNYAKL-IEMNGGGTGCNHELEMIRQ-KLQCVASKLQVLPQKASERLQFETADD 3544
+ L +N + N E + Q +Q A +L +A++ Q AD
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ--RADL 665
Query: 3545 EDFIWVQEN-IDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLT 3603
++ + +N + + +L K+T Q + + + S E L++ E + Q T
Sbjct: 666 QNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 3604 EEKNDLRNMVMKLEEQIRWYRQTG--AGRDNSSRFSLNGGANIEAIIAS-----EKEVWN 3656
EE L + KLE + + A +D + LN + A S EKE+ +
Sbjct: 726 EE---LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
Query: 3657 REKLTLQKSLKRAEAEVYKLKAELRNDSLL----QTLSPDSE 3694
+L LQK + E+ KL + +L +TLS +++
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK 824
Score = 80.5 bits (197), Expect = 3e-14
Identities = 138/640 (21%), Positives = 269/640 (42%), Gaps = 49/640 (7%)
Query: 3071 QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQ 3130
QG++ Q A D + L ++ + +K+ ++ + L I +
Sbjct: 117 QGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIK 176
Query: 3131 SQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTK-LELETTLKAQHKHLKEL 3189
S+ E + + + + T L E+L+ E V+ +LK+EL Q +E LK + ++ L
Sbjct: 177 SKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL 236
Query: 3190 -EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3248
+ LE + +++++ L S+ S L E AK + +EL+ LK S
Sbjct: 237 MDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296
Query: 3249 LE--SQKQRNLQLNLLLEQQKQLLNESQQKIES-QRMLYDAQLSEEQGRNLELQVLLESE 3305
+ +QK + L NLL ++Q E + ES + A L ++ +LQ L +
Sbjct: 297 VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS 356
Query: 3306 KVRIREMSSTLDRERELHAQLQSSDGTGQSR-PPLPSEDLLKELQKQLEEKHSRIVELLN 3364
+ + + L + E +L+ +++ L +E K+LQ+Q EEK ++L +
Sbjct: 357 ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE--FKQLQQQREEKEQHGLQLQS 414
Query: 3365 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3422
E + L+T +Q+ + ++ Q E + ++++ +LQ K+ L+ QL+EK
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474
Query: 3423 -----RQQVYKLDLEGQRLQGIMQE--FQKQELEREEKRESRRILYQNLNEPTTWSLTSD 3475
+ Q+ K + Q Q + Q + +E + + ++ R+I ++ +L
Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534
Query: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKL--QVLPQKA 3533
N L +K +E YAK I+ G T ++L+ LQ ++L ++ Q
Sbjct: 535 SKENISLLEK----EREDLYAK-IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSE 589
Query: 3534 SERLQFETADDE------DFIWVQENIDEIILQLQKLTGQQGEEPSLVSP-STSCGSLTE 3586
S + E D+ Q+ + + + +L Q E VS + TE
Sbjct: 590 SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649
Query: 3587 RLL-------RQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3639
LL Q A+L H+ D + + K+ Q+ + T +D S
Sbjct: 650 LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD--QVTAKLQDKQEHCS-- 705
Query: 3640 GGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3679
+E+ + KE + L+L++ + E ++ KL+A+
Sbjct: 706 ---QLESHLKEYKEKY----LSLEQKTEELEGQIKKLEAD 738
Score = 39.3 bits (90), Expect = 0.077
Identities = 59/314 (18%), Positives = 129/314 (41%), Gaps = 19/314 (6%)
Query: 3408 LQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP 3467
L+ +V+DLQ L+E++ +L E ++ QG+ Q+ K + + + L Q L E
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
Query: 3468 TTWSLTSDRTRNWVLQQKIEGETKESNY-AKLIEMNGGGTGCNHELEMIRQKLQCVASKL 3526
T + + ++ Q+ + T+ ++ +K E ++ + ++L A+ +
Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVI 207
Query: 3527 QVLPQKASERLQFETAD--DEDFIWVQENIDEIILQLQKLTGQQGEE-----PSLVSPST 3579
Q L + +R E ++ + VQ +D + L+ ++ + + +E S
Sbjct: 208 QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEA 267
Query: 3580 SCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMK---LEEQIRWYRQTGAGRDNSSRF 3636
+ L L + E+ ++ +L + K+ + + K L E + Q +
Sbjct: 268 TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE 327
Query: 3637 SLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL-RNDSLLQTLSPDSEH 3695
NI+A + + + + LQ L +E ++++ EL Q L +
Sbjct: 328 ESVSKKNIQATLHQK----DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSE 383
Query: 3696 VTLKRIYGKYLRAE 3709
V K ++L+AE
Sbjct: 384 VETKY---QHLKAE 394
Score = 33.5 bits (75), Expect = 4.3
Identities = 28/133 (21%), Positives = 59/133 (44%), Gaps = 11/133 (8%)
Query: 123 FVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPT-----HLEMMESELAGKQHEIEELNRE 177
F+ + K + ++E+E G+ + +L ++ E Q + EL ++
Sbjct: 1211 FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270
Query: 178 LEEMR--VTYGTEGLQQLQEFEAAIKQR----DGIITQLTANLQQARREKDETMREFLEL 231
+++R + +Q Q+ A+ +R +G I +L + + +R+ D T EL
Sbjct: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
Query: 232 TEQSQKLQIQFQQ 244
++Q LQI+ Q
Sbjct: 1331 GRENQSLQIKHTQ 1343
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 159 bits (403), Expect = 4e-38
Identities = 231/1158 (19%), Positives = 491/1158 (42%), Gaps = 164/1158 (14%)
Query: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
E M + LA K+ E+EE+ +LE RV E Q LQ + ++ A++Q
Sbjct: 907 EEMRARLAAKKQELEEILHDLES-RVEEEEERNQILQNEK----------KKMQAHIQDL 955
Query: 218 RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL 277
+ DE +L + + + ++++ L +S + + +I QL
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015
Query: 278 EEQDHLLEDYQKKKEDFTMQISFLQEKIKV-----YEMEQDKKVENSN----KEEIQEKE 328
E++ ++ K + + IS L+E++K E+E+ K+ + +++I E +
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ 1075
Query: 329 TIIEELNTKIIEEEKKTLELKDKLTTAD----------KLLGELQEQIVQKNQEIKNMKL 378
I+EL ++ ++E+ EL+ L D K++ ELQ QI + ++ ++ K
Sbjct: 1076 AQIDELKLQLAKKEE---ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 379 ELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELD 438
+++++R SEE++ L +E+ +T Q QE + K EQ AEL
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELED---------TLDTTAAQ---QELRTKREQEVAELK 1180
Query: 439 EMYGQQIVQMKQELIRQHMAQMEEMKTRH-------KGEMENALRSYSNITVNEDQIKLM 491
+ +E + H AQ+++M+ RH ++E A R +N+ N+ ++
Sbjct: 1181 KAL--------EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232
Query: 492 NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551
N + LQ ++ E +++L ++E A + + L EL+ ++Q +
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292
Query: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
+ + L EA K A + S + +EL + + N ++ LE+EKN++
Sbjct: 1293 S---TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349
Query: 612 DRMAESQEA--ELER----LRTQL-------------LFSHEEELSKLKEDLE-IEHRI- 650
++ E +EA LE+ L++QL + S EE KL +D E + R+
Sbjct: 1350 EQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409
Query: 651 -------NIEKLKDNLGIHYKQQIDGL------QNEMSQKIETMQFEKDNLITKQNQLIL 697
+EK K+ L +Q++D L Q +++ +E Q + D L+ ++ +
Sbjct: 1410 EKALAYDKLEKTKNRL----QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757
++ +D ++ K + L++ +E + E++ L ++++L + + K
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Query: 758 QMKEKEND---LQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK 814
+ E E L+++ ++ + L+DE + ED K+ V+ + +
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATED-AKLRLEVNMQ------------AM 1572
Query: 815 DSVWEKEIEILIEENEDLKQQCIQLNEEIE-------KQRNTFSFAEKNFEVNYQELQEE 867
+ +E++++ E+NE+ K+ I+ E+E KQR ++K E++ ++L+ +
Sbjct: 1573 KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ 1632
Query: 868 YACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAET 927
K +D++ KQ + ++++K EL R + + +F + K E+
Sbjct: 1633 IEAANKARDEV----IKQLRKLQAQMKDYQRELEEARAS------RDEIFAQSK----ES 1678
Query: 928 LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK--- 984
+ + +E + +L E+L ++R + Q +L++++ S L +E + L+
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 985 -QEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFG 1043
Q +E++ +E++ + R +Q + S A + + NK
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNK--- 1795
Query: 1044 EESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLK 1103
E K + + +SK + I + + + E K + +
Sbjct: 1796 -------ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE 1848
Query: 1104 SEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQK 1163
+ ++ +Q+E +R H DQ +E ME + + + LK +L A+EE +
Sbjct: 1849 KKLKEIFMQVEDER--------RHADQYKEQME-KANARMKQLKRQLEEAEEEATRANAS 1899
Query: 1164 IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223
+L+ + E +EG L + L+ + + S + + E++
Sbjct: 1900 RRKLQRELDDATE-ANEG--LSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELS 1956
Query: 1224 AEDKENSGDYISENEDPE 1241
+D E+ ++E + P+
Sbjct: 1957 DDDTESKTSDVNETQPPQ 1974
Score = 151 bits (381), Expect = 1e-35
Identities = 262/1208 (21%), Positives = 513/1208 (42%), Gaps = 178/1208 (14%)
Query: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284
++ L++T Q ++LQ + ++L + + + ++ HQQ LEE++ L
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEG-------ELEEMERKHQQLLEEKNILA 893
Query: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
E Q + E F E E+ + + K+E++E I+ +L +++ EEE++
Sbjct: 894 EQLQAETELFA-------------EAEEMRARLAAKKQELEE---ILHDLESRVEEEEER 937
Query: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
L+++ + +L+EQ+ ++ + ++LE ++ K ++ EEI L E+
Sbjct: 938 NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL----EDQ 993
Query: 405 QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMK 464
+ K+ + ME QL E ++ ++ KQE++ + + + +
Sbjct: 994 NSKFIKEKKL-------MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKE 1046
Query: 465 TRHKGEMENALRSYSNITVN-EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL----I 519
+ + E+E A R T + +DQI + I+EL ++L ++E+L+ L
Sbjct: 1047 EKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA---KKEEELQGALARGDDET 1103
Query: 520 LEEKCALQ--RQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVS 577
L + AL+ R+L+ + EL E + +R +Q+ L+E ++L T + + +
Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELE---DTLD 1160
Query: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
+ +++EL K E EV K LE K A + M + LE L QL E+
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL-----EQA 1215
Query: 638 SKLKEDLEIEHRINIEKLKDNLGIHYK--QQIDGLQNEMSQKIETMQFEKDNLITKQNQL 695
+ K +LE +++ +E L K QQ+ +K++ E +++ ++L
Sbjct: 1216 KRFKANLE-KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274
Query: 696 ILEIS-KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL 754
+E++ K LQ L N TL +K I+ K+ +LE ++Q+ Q EL
Sbjct: 1275 RVELAEKASKLQNELDNVS----TLLEEAEKKGIKF----AKDAASLESQLQDTQ---EL 1323
Query: 755 LEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK 814
L+++ ++K N L + QLE E + L+++++ E+ K + E++++ L S + +K
Sbjct: 1324 LQEETRQKLN-LSSRIRQLEEEKNSLQEQQEEEEEARK-----NLEKQVLALQSQLADTK 1377
Query: 815 DSVWEK--EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872
V + IE L E + L + L++ +E++ +
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY---------------------- 1415
Query: 873 KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFD----EDKTFVAETL 928
D LE +KN+ + E L L +L QR + ++ K FD E+K+ A
Sbjct: 1416 ---DKLEKTKNRLQQE----LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468
Query: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKE 988
E E+D E + + TK L L++ L + E ++ + L +++ L K+
Sbjct: 1469 E-----ERDRAEAEAREKETK--ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 989 QVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGV-----------VTMTSRGAEGSV 1035
V ELE RA + V+ TQ+ L D + V M + A+
Sbjct: 1522 DVGKNVHELE---KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER 1578
Query: 1036 S-KVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILD-----HLPSVTKESSLRATQP 1089
+ EE K ++ +V + +E KQ L + + E+ + A
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638
Query: 1090 SENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEE 1149
+ D++ K+L L+++ D + ++E R +++ E +K L SL+ E
Sbjct: 1639 A-RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA---------QSKESEKKLKSLEAE 1688
Query: 1150 LIFAQEE--KIKELQKIHQLELQTMKTQETG---------DEGKPLHLLIGKLQKAVSEE 1198
++ QEE + ++ + E + + T DE + L I +L++ + EE
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748
Query: 1199 CS-------YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQD 1251
S F +T V + L E +A K ++ E ++ EL+ E++
Sbjct: 1749 QSNMELLNDRFRKTTLQV--DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEG 1806
Query: 1252 FQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQM 1311
++ E K+ L+ +L + ++ KL E KE F+ + +
Sbjct: 1807 AVKSKFKATISALEA--KIGQLEEQLEQEAKERAAANKLVRRTEKKLKE--IFMQVEDER 1862
Query: 1312 TNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISS---LQQQL---KETEQNYEAEI 1365
+ + + + ++ L K +LEE +E +S LQ++L E + E+
Sbjct: 1863 RHADQYKEQMEKANARMKQL-KRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREV 1921
Query: 1366 HCLQKRLQ 1373
L+ RL+
Sbjct: 1922 STLKNRLR 1929
Score = 149 bits (377), Expect = 4e-35
Identities = 229/1134 (20%), Positives = 478/1134 (42%), Gaps = 192/1134 (16%)
Query: 1550 EEMFSKDKTFIVRQSI-------HDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ 1602
EEM K + + ++I E+ + + +L +++LE++ +L + +E +
Sbjct: 876 EEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE 935
Query: 1603 QATELLR------QAHMRQMERQREDQEQLQEEIK--------RLNRQLAQRSSIDNENL 1648
+ ++L+ QAH++ +E Q +++E +++++ ++ + + ++++N
Sbjct: 936 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 995
Query: 1649 VSERERVLLEELEALKQLSLAGRE---KLCCELRNSSTQTQNGNENQGEVEEQTFKEKEL 1705
+E+ L+E+ A LA E K ++RN + E + + EE+T +E E
Sbjct: 996 KFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055
Query: 1706 DRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS 1765
++ D L ++ LQ ++ ++ L++ K ++ + R D + ++
Sbjct: 1056 AKRKLDGETTDLQDQIAELQA---QIDELKLQLAKKEEELQGALARG-----DDETLHKN 1107
Query: 1766 SASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKV--TEEGTELSQ 1823
+A + R E +A + + + + D+ + +++ T + T Q
Sbjct: 1108 NALKVVR-ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166
Query: 1824 RL-VRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAK---------- 1872
L + E+ EE N +++Q ++ A+ E S QLE AK
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 1873 ----------VTQTELMRESFRQKQEATESLKCQ-EELRERLHEESRAREQLAVELSKAE 1921
+ +++++ + + + L Q +EL ++ E R R +LA + SK +
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 1922 GVIDG--------------YADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQ 1967
+D +A + E Q+Q+ +++ ++ L S+R+++LE E+
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346
Query: 1968 QIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALE 2027
+QE++E ++ ++ + ++ Q L +T+K + + L E+ + L K +AL
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQ-LADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 2028 IDVEEQVSRFIELEQEKN---TELMDL-------RQQNQALEKQLEKMRKFL-DEQAIDR 2076
+EE+ + +LE+ KN EL DL RQ LEK+ +K + L +E++I
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQ 2136
+ + + E + E++ K + + + E E+ K+ +L+ SK+ +
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARAL-EEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524
Query: 2137 RDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERD 2196
+++ E + LE +V E+ L D Q ED K L LEV +QA +
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK----------LRLEVNMQAMK- 1573
Query: 2197 AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKD 2256
QF +L+ ++E+ ++ L Q +E L++ ++ L
Sbjct: 1574 ----------------AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVA 1617
Query: 2257 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV 2316
+K+ + +K+ +A I+ D++ +Q+ KLQ Q+K
Sbjct: 1618 SKKKMEIDLKDLEAQ---------------IEAANKARDEVIKQLRKLQAQMK------- 1655
Query: 2317 IEEKNELIRDLETQIECLMSDQECVKRNREEE--IEQLNEVIEKLQQELANIGQKTSMNA 2374
+ R+LE E S E +++E E ++ L I +LQ+ELA+ +
Sbjct: 1656 -----DYQRELE---EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707
Query: 2375 HSLSEEADSL-------------KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2421
E AD + K +L+ IA+ LE+++E M + + ++T
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQ---LEEELEEEQSNMELLNDRFRKTTL 1764
Query: 2422 KMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVL--TEDALKSLEN 2479
+++ L EL + ER + +K + A L + EL+ L E A+KS
Sbjct: 1765 QVDTLNAELAA---ERSAAQKSDN--------ARQQLERQNKELKAKLQELEGAVKS--- 1810
Query: 2480 QTYFKSFEENGKGSIINLETRLLQ-------LESTVSAKDLELTQCYKQIKDMQEQGQFE 2532
FK+ + I LE +L Q V + +L + + Q++D +
Sbjct: 1811 --KFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQY 1868
Query: 2533 TEMLQKKIVNLQKI------VEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2580
E ++K ++++ EE+ A S+ +L+ +E + N+ +S E
Sbjct: 1869 KEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ--RELDDATEANEGLSRE 1920
Score = 147 bits (370), Expect = 3e-34
Identities = 267/1235 (21%), Positives = 515/1235 (41%), Gaps = 181/1235 (14%)
Query: 1593 ELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSER 1652
++ RQ +E Q E L ++ E+Q + + +L EE++R ++QL + +I E L +E
Sbjct: 846 QVTRQEEELQAKDEEL----LKVKEKQTKVEGEL-EEMERKHQQLLEEKNILAEQLQAET 900
Query: 1653 ERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDV 1712
E L E E ++ A +++L L + ++ + E ++ + +K++ +D+
Sbjct: 901 E--LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNE---KKKMQAHIQDL 955
Query: 1713 PPEILSNERYALQKANNRLLKILLEVVKTTAAVE-ETIGRHVLGILDRSSKSQSSASLIW 1771
E L E A QK L++ K TA + + + +L + D++SK L+
Sbjct: 956 E-EQLDEEEGARQK---------LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Query: 1772 RSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFA 1831
AE S + EE + + ++ +D+ K E+ + ++ R
Sbjct: 1006 DRIAECSSQLAEEEEKAK---NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR---- 1058
Query: 1832 GTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA----------KVTQTELMRE 1881
++D E +L I+ LQA +++L +++ +L+ A K +++RE
Sbjct: 1059 --KLDGETTDLQDQIAE-LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115
Query: 1882 SFRQKQEATESLKCQEELRERLHEESR-AREQLAVELSKAEGVIDGYADEKTLFERQIQE 1940
Q E E + ++ R + ++ R E+L ++ E +D A ++ L ++ QE
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175
Query: 1941 KTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEK 2000
++ LE+E ++Q++ EE Q + KA +Q L + ++
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 2001 L---MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA 2057
L +K +V+ ++E R L QV+ L V E +EL ++ + +L +
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 2058 LEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEH-------QTRE 2110
LE+ +K KF + A +D + ++ Q+L + R + + E Q E
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRD---IQERNEEIEKLEFRVRELEQALLVSADTF 2167
E N K+ S+L +K+++ D I+ E +KL L Q L A +
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415
Query: 2168 QKVEDRKHFGAVEAKPELS-LEVQLQAERDAIDRKEKEITNLEEQL------------EQ 2214
K+E K+ + EL L V L +R EK+ ++ L E+
Sbjct: 1416 DKLEKTKN----RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Query: 2215 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2274
R E E + +E + L + ++ E+ +E E++NK + DME D MS++
Sbjct: 1472 DRAEAEAREKETKALSLARALE--EALEAKEEFERQNKQLRADME---------DLMSSK 1520
Query: 2275 DQHVLFGKFAQIIQEK----EVEIDQLNEQVTKLQQQLKITTDNKVIEEKN------ELI 2324
D GK +++ E +++++ Q+ +L+ +L+ T D K+ E N +
Sbjct: 1521 DD---VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577
Query: 2325 RDLETQIECLMSDQECVKRNREEEIEQLNEVIE--KLQQELANIGQKT-SMNAHSLSEEA 2381
RDL+T+ E E KR +++ +L +E + Q+ LA +K ++ L +
Sbjct: 1578 RDLQTRDE----QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI 1633
Query: 2382 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVL-------KETNFKMNQLTQELFSLK 2434
++ D VI + L+ Q++ E+ + KE+ K+ L E+ L+
Sbjct: 1634 EAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ 1693
Query: 2435 RERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSI 2494
E S E+ + H +++ EL +T A +GK ++
Sbjct: 1694 EELASSERARR-----------HAEQERDELADEITNSA---------------SGKSAL 1727
Query: 2495 INLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA 2554
++ + RL + + Q +++++ Q + + +K + + + E A
Sbjct: 1728 LDEKRRL----------EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777
Query: 2555 LVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQ 2614
+Q A Q+ + ++ + +Q L + + + ISAL +I +LE Q
Sbjct: 1778 SAAQKSDNARQQLER--------QNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQ 1829
Query: 2615 VVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKT 2674
+ + E ++ A K V EKKL E+ +E +E++ ++ K++ + +K
Sbjct: 1830 LEQ-------EAKERAAANKLVRRTEKKLKEIFMQVE-DERRHADQYKEQMEKANARMKQ 1881
Query: 2675 TTELFHSNEESGFFNELEALRAESVATK--AELASYKEKAEKLQEELLVKETNM-----T 2727
EE EA RA + K EL E E L E+ + +
Sbjct: 1882 LKRQLEEAEE-------EATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPI 1934
Query: 2728 SLQKDLSQVRD-HLAEAKEKLSILEKEDETEVQES 2761
S S R HL A +LS +D+TE + S
Sbjct: 1935 SFSSSRSGRRQLHLEGASLELS----DDDTESKTS 1965
Score = 132 bits (332), Expect = 7e-30
Identities = 291/1342 (21%), Positives = 559/1342 (41%), Gaps = 262/1342 (19%)
Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092
QV+R E Q K+ EL+ ++++ +E +LE+M +R+H+ Q LE+
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEM---------ERKHQ--------QLLEE 888
Query: 2093 QLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE----EIEK 2148
+ + + Q +E E E++ L K + E+L E + +ERN+ E +K
Sbjct: 889 KNILAEQLQAETE-LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK 947
Query: 2149 LEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNL 2208
++ +++LE+ L QK++ K + K ++ E+ L ++++ KEK++ +
Sbjct: 948 MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK-KMEEEILLLEDQNSKFIKEKKL--M 1004
Query: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2268
E+++ + +L + E+ + L +I+ K+ + +LE+ K + ++L A ++
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNL---AKIRNKQEVM-ISDLEERLKKEEKTRQELEKAKRKL 1060
Query: 2269 DAMST--QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK---ITTDNKVIEEKNEL 2323
D +T QDQ I E + +ID+L Q+ K +++L+ D++ + + N L
Sbjct: 1061 DGETTDLQDQ----------IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110
Query: 2324 --IRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2381
+R+L+ QI L D E K +R + +Q + LSEE
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRD----------------------LSEEL 1148
Query: 2382 DSLKHQLDVVIAEKLALEQQVETANE-EMTFMKNVLKETNFKMNQLTQELFSLKRERESV 2440
++LK +L+ + + A +Q++ T E E+ +K L+E Q++ +R ++
Sbjct: 1149 EALKTELEDTL-DTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM--RQRHATAL 1205
Query: 2441 EKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETR 2500
E++ E + + L K+K LE E A + Q E K L+ +
Sbjct: 1206 EELSEQLEQAKRFKAN-LEKNKQGLETDNKELACEVKVLQQVKAESEHKRK----KLDAQ 1260
Query: 2501 LLQLESTVSAKD---LELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS 2557
+ +L + VS D +EL + + LQ ++ N+ ++EE
Sbjct: 1261 VQELHAKVSEGDRLRVELAE--------------KASKLQNELDNVSTLLEE-------- 1298
Query: 2558 QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVE 2617
A ++ KF +D ++ S+ +Q+ +L ++E ++ L+ RI +LE E
Sbjct: 1299 -----AEKKGIKFAKDAASLESQ-----LQDTQELLQEETRQKLN-LSSRIRQLE----E 1343
Query: 2618 MHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK---------QREKEKKRSPQD 2668
SL ++E+ E A KN+ EK++L LQ L +KK E+ KK+ +D
Sbjct: 1344 EKNSLQEQQEEEEEARKNL---EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKD 1400
Query: 2669 VEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTS 2728
E L E E++ +++LE + +LQ+EL
Sbjct: 1401 AEALSQRLE-----EKALAYDKLEKTK-----------------NRLQQEL--------- 1429
Query: 2729 LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI 2788
DL+ DH + L +K+ + + E K +S A + D
Sbjct: 1430 --DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS----------ISARYAEERDRAEAE 1477
Query: 2789 SSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHIS 2848
+ +T + + A EE E +F + ++++ DME S
Sbjct: 1478 AREKETKALSLARA-----------LEEALEAKEEFERQNKQLRA-------DMEDLMSS 1519
Query: 2849 ETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPEL-AHSDAYQTREICSSDSGS 2907
+ + K H L++ L+ ++ +R++ EL A DA E+ +
Sbjct: 1520 KDDVGKNVHE-----LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 2908 DWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSD 2967
+ + + + R E++E K+++ L + +E Q S
Sbjct: 1575 QFERDL------------QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS---- 1618
Query: 2968 GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL 3027
++ E L++ +A I + +D + K + +A++ D + E R E+
Sbjct: 1619 ------KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672
Query: 3028 LALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR 3087
+ E L + E+ L L + R + + A E A
Sbjct: 1673 AQSK-----ESEKKLKSLEAEILQLQEE----LASSERARRHAEQERDELADEITNSASG 1723
Query: 3088 RS-LLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDR 3146
+S LL E + L A++ L+ E E E+ + ELL ++ Q+ + EL++ +
Sbjct: 1724 KSALLDEKRRLEARI----AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1779
Query: 3147 ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKH-LKELEAFRLEVKDKTDEVHL 3205
A + + ELK++L ELE +K++ K + LEA +++++ ++
Sbjct: 1780 AQKSDNARQQLERQNKELKAKLQ----ELEGAVKSKFKATISALEAKIGQLEEQLEQE-- 1833
Query: 3206 LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ 3265
A E+ + +L EK+ ++ E ++ + K +E R QL LE+
Sbjct: 1834 -----AKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE 1888
Query: 3266 QKQ---LLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIR-----EMSSTLD 3317
++ N S++K+ QR L DA + E G + E+ L K R+R SS+
Sbjct: 1889 AEEEATRANASRRKL--QRELDDATEANE-GLSREVSTL----KNRLRRGGPISFSSSRS 1941
Query: 3318 RERELH---AQLQSSDGTGQSR 3336
R+LH A L+ SD +S+
Sbjct: 1942 GRRQLHLEGASLELSDDDTESK 1963
Score = 131 bits (330), Expect = 1e-29
Identities = 230/1078 (21%), Positives = 469/1078 (43%), Gaps = 189/1078 (17%)
Query: 1878 LMRESFRQKQEATESLK-----CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKT 1932
L R++F +KQ+ +LK C L+ R + R +K + ++ + T
Sbjct: 801 LARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRV-------FTKVKPLL-----QVT 848
Query: 1933 LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA---MKAEAGP 1989
E ++Q K + + +++++ L+E+E + QQ+ EE+ +L+ Q +A + AEA
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 908
Query: 1990 VEQQLL---QETEKLMKEKLEVQCQAEKVRDDL----QKQVKALEIDVEEQVSRFIELEQ 2042
+ +L QE E+++ + LE + + E+ R+ + +K+++A D+EEQ+ E+
Sbjct: 909 MRARLAAKKQELEEILHD-LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD-----EE 962
Query: 2043 EKNTELMDLRQQN-QALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL----KVV 2097
E + + L + +A K++E+ L++Q E+ + + I + QL +
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022
Query: 2098 PRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE 2157
I Q + L LK++ EL +K +L + + ++I +L+ ++ EL+
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082
Query: 2158 QALLVSADTFQKV------EDRKHFGAVEAKPEL-----SLEVQLQAERDAIDRKEKEIT 2206
L + Q E A++ EL L+ ++E+ + ++ EK+
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 2207 NLEEQLEQFREELEN--------------KNEEVQQLHMQLEIQKKESTTRLQELEQEN- 2251
+L E+LE + ELE+ + +EV +L LE + K ++Q++ Q +
Sbjct: 1143 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202
Query: 2252 -------------KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2298
K FK ++EK ++ + + VL Q+ E E + +L+
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL----QQVKAESEHKRKKLD 1258
Query: 2299 EQVTKLQ------QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK-----RNREE 2347
QV +L +L++ K + +NEL ++ T +E ++++ +K + E
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNEL-DNVSTLLE--EAEKKGIKFAKDAASLES 1315
Query: 2348 EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE 2407
+++ E++++ ++ N+ S L EE +SL+ Q + + LE+QV
Sbjct: 1316 QLQDTQELLQEETRQKLNL----SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371
Query: 2408 EMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEV 2467
++ K + + + L + L ++ E++ Q + E + +A D L K K L+
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS--QRLEEKA--LAYDKLEKTKNRLQQ 1427
Query: 2468 VLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQE 2527
L +D L++Q S NLE + + + + A++ ++ Y + +D E
Sbjct: 1428 EL-DDLTVDLDHQRQVAS----------NLEKKQKKFDQLL-AEEKSISARYAEERDRAE 1475
Query: 2528 QGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQ 2587
E + K ++L + +EE LEA +E+ + Q+ Q R +++
Sbjct: 1476 A---EAREKETKALSLARALEE----------ALEAKEEFER--QNKQL------RADME 1514
Query: 2588 NLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL---------- 2637
+L +D++G ++ L LE QV EM T L +++++ E L
Sbjct: 1515 DL-MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573
Query: 2638 --------------EKEKKLL-----ELQKLLEGNEKKQRE---KEKKRSPQDVEVLKTT 2675
E++K+LL EL+ LE +E+KQR KK+ D++ L+
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAELE-DERKQRALAVASKKKMEIDLKDLEAQ 1632
Query: 2676 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2735
E + + +L L+A+ + EL + +++ + E + SL+ ++ Q
Sbjct: 1633 IEAANKARDE-VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQ 1691
Query: 2736 VRDHLAEAKEKLSILEKE-----DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISS 2790
+++ LA ++ E+E DE S K+ + + +L IA Q + L+
Sbjct: 1692 LQEELASSERARRHAEQERDELADEITNSASGKSALLDE-KRRLEARIA-QLEEELEEEQ 1749
Query: 2791 SNQ----------TPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIE-KMQELHAA 2837
SN T Q+ NA + + S+ + + + ++++ K+QEL A
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGA 1807
Score = 130 bits (327), Expect = 3e-29
Identities = 231/1094 (21%), Positives = 464/1094 (42%), Gaps = 140/1094 (12%)
Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757
E+ K+K+ +Q+ V + EEM + +L +E IL ++ + + L E +E++ + ++
Sbjct: 860 ELLKVKE-KQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918
Query: 758 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK-IHTPVSQEE---RLIFLDSIKSKS 813
+++E +DL+ + + E N IL++EKK ++ ++ + + +EE + + L+ + +++
Sbjct: 919 ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEA 978
Query: 814 KDSVWEKEIEILIEEN----------EDLKQQC-IQLNEEIEKQRNTFSFAEKNFEVNYQ 862
K E+EI +L ++N ED +C QL EE EK +N K EV
Sbjct: 979 KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ-EVMIS 1037
Query: 863 ELQEEYACLLKVKDDLEDSKNKQELEYK------SKLKALNEELHLQRINPTTVKMKSSV 916
+L+E K + +LE +K K + E ++L+A +EL LQ +
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA 1097
Query: 917 FDEDKTF-VAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI-- 973
+D+T L++ ++ EL E E K + + ++ DLSE+L+ E+
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELED 1157
Query: 974 ----SFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSR 1029
+ +E+++ K+E+E L+ E NH +Q + ++ L+ + +
Sbjct: 1158 TLDTTAAQQELRT-KREQEVAELKKALEEETKNHE--AQIQDMRQRHATALEELSEQLEQ 1214
Query: 1030 GA--EGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL---ILDHLPSVTKESSL 1084
+ ++ K + ++K + + + + E K+++L + + V++ L
Sbjct: 1215 AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274
Query: 1085 RATQPSENDKLQKELN-----VLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEK 1139
R + KLQ EL+ + ++E+ ++ +A + L + + Q +
Sbjct: 1275 RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL 1334
Query: 1140 DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQ-ETGDEGKPLHLLIGKLQKAVSEE 1198
+ L+EE QE++ +E + LE Q + Q + D K + +G ++ EE
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESL--EE 1392
Query: 1199 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED---PELQDYRYEVQDFQEN 1255
L L + E+K + D + + ++ EL D ++ D Q
Sbjct: 1393 AKKKLLKDAEALSQ----------RLEEKALAYDKLEKTKNRLQQELDDLTVDL-DHQRQ 1441
Query: 1256 MHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE------------ENLPKEETE 1303
+ + L K +++++LL + +S + ++ D + E E E + + E
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 1304 FLSIHSQM-TNLEDIDVNHKSKLSSLQDLEKTK--LEEQVQELESLISSLQQQLKETEQ- 1359
F + Q+ ++ED+ + ++ +LEK+K LE+QV+E+ + + L+ +L+ TE
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561
Query: 1360 ------NYEAEIHCLQKRLQAVSESTVPPS-LPVDSVVITESD-----AQRTMYPGSCVK 1407
N +A ++ LQ E L + V E++ QR + S K
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621
Query: 1408 KNID-GTIEFSGEFGVKEETNIVKLLE------KQYQEQLEEEVAKVIVSMSIAFAQQTE 1460
ID +E E K ++K L K YQ +LEE A S FAQ E
Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA----SRDEIFAQSKE 1677
Query: 1461 LSR--------ISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKE 1512
+ I +E ASS++A +QE+ + +++ G + +
Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD-EITNSASGKSALLDEKRRLEA 1736
Query: 1513 EFKPLSKELGEHGKEILLSNSDPHDIPESKDCV-LTISEEMFSKDKTFIVRQSI---HDE 1568
L +EL E + L N D + ++ E + K+ RQ + + E
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796
Query: 1569 ISVSSMDA--------SRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMR------ 1614
+ + + E ++ + ++L ++ +E A +L+R+ +
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856
Query: 1615 QMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKL 1674
Q+E +R +Q +E++++ N ++ Q + LEE E + A R KL
Sbjct: 1857 QVEDERRHADQYKEQMEKANARMKQL-------------KRQLEEAEEEATRANASRRKL 1903
Query: 1675 CCELRNSSTQTQNG 1688
EL + +T+ G
Sbjct: 1904 QREL-DDATEANEG 1916
Score = 126 bits (316), Expect = 5e-28
Identities = 276/1323 (20%), Positives = 560/1323 (42%), Gaps = 293/1323 (22%)
Query: 728 IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL 787
+++ RQEE ELQ K E L K +KEK+ ++ + ++E ++ L +EK L
Sbjct: 845 LQVTRQEE-----------ELQAKDEELLK-VKEKQTKVEGELEEMERKHQQLLEEKNIL 892
Query: 788 EDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQR 847
+ L Q E +F ++ + +++ + ++E+E ++ + E ++ + N+ ++ ++
Sbjct: 893 AEQL-------QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945
Query: 848 NTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEY---KSKLKALNEELHLQR 904
K + + Q+L+E+ D+ E ++ K +LE ++K+K + EE+ L
Sbjct: 946 -------KKMQAHIQDLEEQL-------DEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991
Query: 905 INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTK-----REKLELSQRL 959
D++ F+ E M + + + +++L E+ E K R K E+ +
Sbjct: 992 -------------DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM--I 1036
Query: 960 SDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSL 1019
SDL E+LK++ L + + L E + + EL+ I+ + + + + +L
Sbjct: 1037 SDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGAL 1096
Query: 1020 LDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVT 1079
+RG + ++ K N K++ E + + ES
Sbjct: 1097 --------ARGDDETLHKNNAL-----KVVRELQAQIAELQEDFES-------------- 1129
Query: 1080 KESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEK 1139
E + R + L +EL LK+E D AQ+ ++R E E
Sbjct: 1130 -EKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ------------ELRTKREQEV 1176
Query: 1140 DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAV---S 1196
+ +L+EE E +I+++++ H L+ + Q ++ K + K ++ + +
Sbjct: 1177 AELKKALEEETK-NHEAQIQDMRQRHATALEELSEQL--EQAKRFKANLEKNKQGLETDN 1233
Query: 1197 EECSYFLQTLCSVLGEYYTPALKCEVNAED---KENSGDYISENEDPELQDYRYEVQDFQ 1253
+E + ++ L V E K + ++ K + GD + EL + ++Q+
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV----ELAEKASKLQNEL 1289
Query: 1254 ENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313
+N+ TLL + ++ K L +L+ +E L +E + L++ S++
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLES---------QLQDTQELLQEETRQKLNLSSRIRQ 1340
Query: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQ---- 1369
LE+ K+ L Q+ E EE + LE + +LQ QL +T++ + ++ ++
Sbjct: 1341 LEE----EKNSLQEQQEEE----EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392
Query: 1370 ------KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVK 1423
K +A+S+ +L D + T++ Q+ + D T++ + +
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD---------DLTVDLDHQ---R 1440
Query: 1424 EETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQ 1483
+ + ++ +K++ + L EE S+S +A++ + + ++ T + A A+ +
Sbjct: 1441 QVASNLEKKQKKFDQLLAEEK-----SISARYAEERDRAEAEAREKETKALSLARALEEA 1495
Query: 1484 EQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKD 1543
++ KEEF+ +K+L +D D+ SKD
Sbjct: 1496 ------------------------LEAKEEFERQNKQL----------RADMEDLMSSKD 1521
Query: 1544 CVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQ 1603
V +++H+ ++ S++ + E+Q+E+MR +L + ++ Q
Sbjct: 1522 DV----------------GKNVHE------LEKSKRAL--EQQVEEMRTQL-EELEDELQ 1556
Query: 1604 ATELLR-------QAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVL 1656
ATE + QA Q ER + +++ EE KRL + Q ++ E
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL--LIKQVRELEAE---------- 1604
Query: 1657 LEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK----EKELDRKPEDV 1712
LE+ + L++A ++K+ +L++ Q + N+ + EV +Q K K+ R+ E+
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664
Query: 1713 PPEILSNERYALQKANNRLLKIL----LEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
+E +A K + + LK L L++ + A+ E R Q
Sbjct: 1665 RAS--RDEIFAQSKESEKKLKSLEAEILQLQEELASSERA----------RRHAEQERDE 1712
Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM------WSKVTEEGTELS 1822
L AS KS + +E R+ E+ + ++ NM + K T + L+
Sbjct: 1713 LADEITNSASGKSALLDEKRRL--EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770
Query: 1823 QRLV-------RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQ 1875
L +S A +++ +N+EL + L+ AV+ +A T S LE AK+ Q
Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKELKAKLQE-LEGAVKSKFKA---TISALE-AKIGQ 1825
Query: 1876 TELMRESFRQKQEATESL--KCQEELRE---RLHEESRAREQLAVELSKAEGVIDGYADE 1930
E E +++ A L + +++L+E ++ +E R +Q ++ KA A
Sbjct: 1826 LEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKAN------ARM 1879
Query: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMK---AEA 1987
K L +RQ++E E+E A+ ++L+ E E E LSR+ +K
Sbjct: 1880 KQL-KRQLEEA-------EEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1931
Query: 1988 GPV 1990
GP+
Sbjct: 1932 GPI 1934
Score = 118 bits (296), Expect = 1e-25
Identities = 229/1095 (20%), Positives = 454/1095 (41%), Gaps = 198/1095 (18%)
Query: 1294 EENLPKEETEFLSIHSQMTN----LEDIDVNHKSKLSSLQDLEKTKLEEQVQ---ELESL 1346
EE L ++ E L + + T LE+++ H+ L EK L EQ+Q EL +
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLE-----EKNILAEQLQAETELFAE 905
Query: 1347 ISSLQQQLKETEQNYEAEIHCLQKRLQAVSEST--VPPSLPVDSVVITESDAQRTMYPGS 1404
++ +L +Q E +H L+ R++ E + I + + Q G+
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 1405 CVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEE--VAKVIVSMSIAFAQQTE-- 1460
K ++ + + E +K+ + LLE Q + ++E+ + I S A++ E
Sbjct: 966 RQKLQLE---KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022
Query: 1461 --LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD----------- 1507
L++I +E S + ++E+ E++ ++ ++ +T + D
Sbjct: 1023 KNLAKIRNKQEVMISDLEERL--KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080
Query: 1508 --VKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE----EMFSKDKTFIV 1561
++ ++ + L L E L N+ + E + + + E E S++K
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 1562 RQSIHDEI---------SVSSMDASRQLMLNEEQ-LEDMRQELVRQYQEHQQATELLRQA 1611
++ + +E+ ++ + A ++L EQ + ++++ L + + H+ + +RQ
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR 1200
Query: 1612 HMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGR 1671
H +E E EQ + L + Q DN+ L E ++ L+ +K S R
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEKN-KQGLETDNKELACE-----VKVLQQVKAESEHKR 1254
Query: 1672 EKLCCELRNSSTQTQNGNENQGEVEEQTFK-EKELDRKPEDVPPEILSNERYALQKANNR 1730
+KL +++ + G+ + E+ E+ K + ELD N L++A +
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD------------NVSTLLEEAEKK 1302
Query: 1731 LLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRV 1790
+K + + +++T + +L R + SS E + + EE R
Sbjct: 1303 GIKFAKDAASLESQLQDT--QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360
Query: 1791 TDE----SIPSYSGSDMPRNDINMWS---------KVTEEGTELSQRLVRSGFAGTEIDP 1837
E ++ S + D ++ + K+ ++ LSQRL A +++
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE- 1419
Query: 1838 ENEELMLNISSRLQAAVEKL---LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK 1894
+RLQ ++ L L+ + +S LE + +L+ E E + S +
Sbjct: 1420 -------KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE------EKSISAR 1466
Query: 1895 CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQE-KTDIID------- 1946
EE R+R E+R +E A+ L++A ++ + K FERQ ++ + D+ D
Sbjct: 1467 YAEE-RDRAEAEAREKETKALSLARA---LEEALEAKEEFERQNKQLRADMEDLMSSKDD 1522
Query: 1947 -------------RLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ 1993
LEQ++ +L+ELE E Q ++ + L +AMKA+ Q
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582
Query: 1994 LLQETEK----LMKEKLEVQCQAEKVRDDLQKQV---KALEIDV---EEQVSRFIELEQE 2043
++ E+ L+K+ E++ + E R V K +EID+ E Q+ + E
Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642
Query: 2044 KNTELMDLRQQNQALEKQLEKMRKFLDE---QAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
+L L+ Q + +++LE+ R DE Q+ + E + + EI +L+++L R
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702
Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE------------- 2147
+ H +E ++LA+ + S LL K +L+ I + EE+E
Sbjct: 1703 R---RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759
Query: 2148 -KLEFRVRELEQALLVSADTFQKVEDRKHF----------------GAVEAKPELSL--- 2187
K +V L L QK ++ + GAV++K + ++
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819
Query: 2188 -----EVQLQAERDA---------IDRKEKEITNLEEQLE-------QFREELENKNEEV 2226
+++ Q E++A + R EK++ + Q+E Q++E++E N +
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM 1879
Query: 2227 QQLHMQLEIQKKEST 2241
+QL QLE ++E+T
Sbjct: 1880 KQLKRQLEEAEEEAT 1894
Score = 113 bits (283), Expect = 3e-24
Identities = 197/976 (20%), Positives = 415/976 (42%), Gaps = 168/976 (17%)
Query: 2 EDEERQKKLEAGKAK---LAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNID 58
E+EE+ K L + K + + + + + ++ + +K KRK D+ +
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ--DQIAEL 1074
Query: 59 QSQCNEMYINSSQRVESTVIPESTIMR----TLHSGEITSHEQGFSVELESEISTTADDC 114
Q+Q +E+ + +++ E + + R TLH + EL+++I+ +D
Sbjct: 1075 QAQIDELKLQLAKKEEEL---QGALARGDDETLHKNNALKVVR----ELQAQIAELQEDF 1127
Query: 115 SSEVNGCSFVMRTGKPTNLLREE----EFGVDDSYSEQGAQDSPTHLEMMESELAGK-QH 169
SE + + K L EE + ++D+ AQ EL K +
Sbjct: 1128 ESEKASRN---KAEKQKRDLSEELEALKTELEDTLDTTAAQQ----------ELRTKREQ 1174
Query: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFL 229
E+ EL + LEE + + Q A+++ L+ L+QA+R K +
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEE-------LSEQLEQAKRFKANLEKNKQ 1227
Query: 230 ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQK 289
L +++L + + LQ + S H D Q+ ++ E D L + +
Sbjct: 1228 GLETDNKELACEVKVLQ--QVKAESEHKRKKLDA-----QVQELHAKVSEGDRLRVELAE 1280
Query: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK 349
K ++ + ++ E + K +++ E Q ++T +EL + EE ++ L L
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT--QEL---LQEETRQKLNLS 1335
Query: 350 DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409
++ ++ LQEQ ++ + KN++ ++ + + + +++ +GT+E L++
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 410 KDSQFETDIVQRMEQET------QRKLEQLRAELDEM-----YGQQI---VQMKQELIRQ 455
K + + QR+E++ ++ +L+ ELD++ + +Q+ ++ KQ+ Q
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 456 HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA----------------INELN 499
+A+ + + R+ E + A E + K +++A +L
Sbjct: 1456 LLAEEKSISARYAEERDRA-----EAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510
Query: 500 IKLQDTNSQKEKLKEELGLILEEKCALQR-------QLEDLVEELSFSRE---------- 542
++D S K+ + + + + + K AL++ QLE+L +EL + +
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 543 ----QIQRARQTIAEQESKLNEAHKSL--STVEDLKAEIVSASESRKELEL------KHE 590
Q +R QT EQ NE K L V +L+AE+ + RK+ L K E
Sbjct: 1571 AMKAQFERDLQTRDEQ----NEEKKRLLIKQVRELEAEL---EDERKQRALAVASKKKME 1623
Query: 591 AEVTNYKIKLEMLEKEKNAVLDRMAESQ------EAELERLRTQL--LFSHEEELSKLKE 642
++ + + ++E K ++ V+ ++ + Q + ELE R +F+ +E K +
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683
Query: 643 DLEIEHRINIEKLKDNLGI--HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS 700
LE E I +L++ L ++ + ++E++ +I K L+ ++ +L I+
Sbjct: 1684 SLEAE----ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIA 1739
Query: 701 KLKD------LQQSLVNSKSEEMTLQINELQKEIEILR----QEEKEKGTLEQEVQELQL 750
+L++ L+N + + TLQ++ L E+ R + + + LE++ +EL+
Sbjct: 1740 QLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKA 1799
Query: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
K + LE +K K + + LEA+ L+++ LE K ++ R
Sbjct: 1800 KLQELEGAVKSK---FKATISALEAKIGQLEEQ---LEQEAKERAAANKLVRRT------ 1847
Query: 811 SKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC 870
EK+++ + + ED ++ Q E++EK ++ E +E A
Sbjct: 1848 --------EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899
Query: 871 LLKVKDDLEDSKNKQE 886
K++ +L+D+ E
Sbjct: 1900 RRKLQRELDDATEANE 1915
Score = 97.4 bits (241), Expect = 2e-19
Identities = 242/1190 (20%), Positives = 468/1190 (39%), Gaps = 209/1190 (17%)
Query: 2726 MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGT 2785
+T +++L + L + KEK + + E E E E K + E I L++ + ++T+
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQT--KVEGELEEMERKHQQLLEEKNI-LAEQLQAETE-- 901
Query: 2786 LKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR 2845
L + ++ K +E+ EI+ ++E+ +E + +IL E +
Sbjct: 902 LFAEAEEMRARLAAKK-------------QELEEILHDLESRVEEEEERN--QILQNEKK 946
Query: 2846 ----HISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREIC 2901
HI + E E A Q L+ E T +A I+ + +E + E +S + +++
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK--KMEEEILLLEDQNSKFIKEKKLM 1004
Query: 2902 SSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLT 2961
E R E S +K K L + + + + + L
Sbjct: 1005 ------------------------EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE 1040
Query: 2962 ESPYSDGEDHSIQQVSEPWLEERKAYIN-TISSLKDLITKMQLQREAEVYDSSQSHESFS 3020
E E+ + Q+ LE+ K ++ + L+D I ++Q Q +
Sbjct: 1041 ERLKK--EEKTRQE-----LEKAKRKLDGETTDLQDQIAELQAQID-------------- 1079
Query: 3021 DWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAME 3080
EL L L + +E + A R + L +A+ ++ L+ +I E ++++
Sbjct: 1080 ----ELKLQLAK---KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 3081 CLQKADR--RSLLSEIQALHAQMNGRKITLKREQE-SEKPSQELLEYNIQQKQSQMLEMQ 3137
KA++ R L E++AL ++ T +QE K QE+ E + + + +
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK-KALEEETKNHE 1191
Query: 3138 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3197
++ M+ R E+LS + K+ L + K LET K +K L+ + E +
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 3198 DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS--------EERDKEELEDLK--F 3247
K ++ L ++ + L+ L ++ +KL EE +K+ ++ K
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311
Query: 3248 SLESQKQRNLQLNLLLEQQKQLLNES---QQKIESQRMLYDAQLSEEQGR-NLELQVL-- 3301
SLESQ Q + LL E+ +Q LN S +Q E + L + Q EE+ R NLE QVL
Sbjct: 1312 SLESQLQDTQE--LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLAL 1369
Query: 3302 --------------------LESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS 3341
LE K ++ + + L + E A ++R
Sbjct: 1370 QSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429
Query: 3342 EDLLKELQKQ------LEEKHSRIVELL-----------------------NETEKYKL- 3371
+DL +L Q LE+K + +LL ET+ L
Sbjct: 1430 DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489
Query: 3372 ----DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 3427
++L+ +++ E+ + R ++ + + K +HEL+ L++Q+EE R Q+
Sbjct: 1490 RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549
Query: 3428 KLDLEGQ-------RLQGIMQEFQKQ-----ELEREEKRESRRILYQNLNEPTTWSLTSD 3475
+L+ E Q RL+ MQ + Q + E+ E +R+L + + E L +
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA-ELEDE 1608
Query: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3535
R Q+ + +K+ L ++ N + + ++L+ + ++++ ++ E
Sbjct: 1609 RK-----QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEE 1663
Query: 3536 RLQFETADDEDFIWVQE------NIDEIILQLQKLTGQ--------QGEEPSLVSPSTSC 3581
+ DE F +E +++ ILQLQ+ + E L T+
Sbjct: 1664 A---RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720
Query: 3582 GSLTERLLRQNAELTGHISQLTEEKND-------LRNMVMKLEEQIRWYRQTGAGRDNSS 3634
S LL + L I+QL EE + L + K Q+ A +++
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780
Query: 3635 RFSLNGGANIE----AIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLS 3690
+ S N +E + A +E+ K + ++ EA++ +L+ +L ++ + +
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840
Query: 3691 PDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFT 3750
T K++ +++ E R+ K+ + E +A + L R +
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYKEQM--------EKANARMKQLKRQLEEAEEE 1892
Query: 3751 DLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDG 3800
+R K A + +SR ++ R G +S + +R G
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSG 1942
Score = 96.7 bits (239), Expect = 4e-19
Identities = 239/1169 (20%), Positives = 474/1169 (40%), Gaps = 183/1169 (15%)
Query: 1105 EQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEE--KIKELQ 1162
+Q L QR C + + H R + + + + +EEL EE K+KE Q
Sbjct: 809 KQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQ 868
Query: 1163 KIHQLELQTM--KTQETGDEGKPLHLLIGKLQK-----AVSEECSYFLQTLCSVLGEYYT 1215
+ EL+ M K Q+ +E ++L +LQ A +EE L L E
Sbjct: 869 TKVEGELEEMERKHQQLLEEK---NILAEQLQAETELFAEAEEMRARLAAKKQELEEILH 925
Query: 1216 PALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT--------LLNKVTEEY 1267
L+ V E++ N I +NE ++Q + +QD +E + L KVT E
Sbjct: 926 D-LESRVEEEEERNQ---ILQNEKKKMQAH---IQDLEEQLDEEEGARQKLQLEKVTAEA 978
Query: 1268 N------KLLVLQTRLSK-IWGQQTDGMKLEFGEENLPKEETEFLSI----HSQMTNLED 1316
++L+L+ + SK I ++ ++ L +EE + ++ + Q + D
Sbjct: 979 KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISD 1038
Query: 1317 IDVNHKSKLSSLQDLEKTK---------LEEQVQELESLISSLQQQLKETEQNYEAEI-H 1366
++ K + + Q+LEK K L++Q+ EL++ I L+ QL + E+ + +
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098
Query: 1367 CLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEET 1426
+ L + V L + E K+ D + E E+T
Sbjct: 1099 GDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDT 1158
Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVC----- 1481
+++ + + E+EVA+ + A ++T+ + +Q HA
Sbjct: 1159 LDTTAAQQELRTKREQEVAE----LKKALEEETK-----NHEAQIQDMRQRHATALEELS 1209
Query: 1482 -QQEQHYFNEMKLSQDQIGFQTFE---TVDVKFKEEFKPLS----KELGEHGKEILLSNS 1533
Q EQ + L +++ G +T +VK ++ K S K+L +E+ S
Sbjct: 1210 EQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS 1269
Query: 1534 D-----------PHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLML 1582
+ + D V T+ EE K F D S+ S Q +L
Sbjct: 1270 EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA-----KDAASLESQLQDTQELL 1324
Query: 1583 NEEQLEDMR-QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRS 1641
EE + + +RQ +E + + + Q E + E ++ L++++ L QLA
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQ-------EQQEEEEEARKNLEKQVLALQSQLADTK 1377
Query: 1642 SIDNENL-----VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE 1696
+++L + E ++ LL++ EAL Q EK + T+ N Q E++
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRL---EEKALAYDKLEKTK----NRLQQELD 1430
Query: 1697 EQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGI 1756
+ T +LD + + + SN L+K + ++L E +A E R
Sbjct: 1431 DLTV---DLDHQRQ-----VASN----LEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 1757 LDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRN--DINMWSKV 1814
++ +K+ S A + EA + + R E + S S D+ +N ++ +
Sbjct: 1479 REKETKALSLARAL-EEALEAKEEFERQNKQLRADMEDLMS-SKDDVGKNVHELEKSKRA 1536
Query: 1815 TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSR-LQAAVEKLLEAISETSSQLEHAKV 1873
E+ E R E+ +L L ++ + ++A E+ L+ E + + + +
Sbjct: 1537 LEQQVE-EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 1874 TQT-EL---MRESFRQKQEATESLKCQE----ELRERLHEESRAREQLAVELSKAEGVID 1925
Q EL + + +Q+ A S K E +L ++ ++AR+++ +L K + +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985
Y +R+++E D + + + +L+ LEAE Q+QEE R + +
Sbjct: 1656 DY-------QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708
Query: 1986 EAGPVEQQLLQETE---KLMKEKLEVQCQAEKVRDDLQKQVKALEI-------------D 2029
E + ++ L+ EK ++ + ++ ++L+++ +E+
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT 1768
Query: 2030 VEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR-----KF-------------LDE 2071
+ +++ Q+ + L +QN+ L+ +L+++ KF L+E
Sbjct: 1769 LNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE 1828
Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131
Q ER + +++ E++LK + F + + + A+ KE+ +K + +
Sbjct: 1829 QLEQEAKERAAANKLVRRTEKKLKEI--FMQVEDERRH-----ADQYKEQMEKANARM-- 1879
Query: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQAL 2160
+QL+R ++E EE + R+L++ L
Sbjct: 1880 -KQLKRQLEEAEEEATRANASRRKLQREL 1907
Score = 94.4 bits (233), Expect = 2e-18
Identities = 259/1248 (20%), Positives = 500/1248 (40%), Gaps = 244/1248 (19%)
Query: 908 TTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLK 967
T VK V +++ A+ E+ +V EK T ++ +LE +R+ +L + + L+EQL
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLKVKEKQT-KVEGELEEMERKHQQLLEEKNILAEQL- 896
Query: 968 QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027
Q E+ EE+++ K+Q ELE I+ H+ V+ + +
Sbjct: 897 QAETELFAEAEEMRARLAAKKQ------ELEEIL-HDLESRVEEEEER------------ 937
Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT 1087
N+ E K M E EE +++L L+ VT E+ ++
Sbjct: 938 -----------NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE---KVTAEAKIK-- 981
Query: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147
K+++E+ +L+ + + + + ++ S Q+ E E K+ A K
Sbjct: 982 ------KMEEEILLLEDQNSKFIKEKKLMEDRIAECSS----QLAEEEEKAKNLAKIRNK 1031
Query: 1148 EELIFAQ-EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206
+E++ + EE++K+ +K Q EL+ K + G E L I +LQ + E
Sbjct: 1032 QEVMISDLEERLKKEEKTRQ-ELEKAKRKLDG-ETTDLQDQIAELQAQIDE--------- 1080
Query: 1207 CSVLGEYYTPALKCEVNAEDKENSGDYISENEDP-----------ELQDYRYEVQDFQEN 1255
LK ++ +++E G +++ ELQ E+Q+ E+
Sbjct: 1081 -----------LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129
Query: 1256 MHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENL-PKEETEFLSIHSQMTNL 1314
NK ++ L L + + D + ++ L K E E + L
Sbjct: 1130 EKASRNKAEKQKRDL---SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA---L 1183
Query: 1315 EDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEA---EIHCLQKR 1371
E+ NH++++ ++ T LEE ++LE + L++ +Q E E+ C K
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQA-KRFKANLEKNKQGLETDNKELACEVKV 1242
Query: 1372 LQAVSESTVPPSLPVDSVV------ITESDAQRTMYPGSCVK-----KNIDGTIEFSGEF 1420
LQ V + +D+ V ++E D R K N+ +E + +
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK 1302
Query: 1421 GVKEETNIVKLLEKQYQE--QLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
G+K + L E Q Q+ +L +E + +++S SRI +E S ++
Sbjct: 1303 GIKFAKDAASL-ESQLQDTQELLQEETRQKLNLS---------SRIRQLEEEKNSLQE-- 1350
Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
QQE+ L + + Q+ + D K K + + E E K+ LL +++
Sbjct: 1351 ---QQEEEEEARKNLEKQVLALQS-QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS- 1405
Query: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEIS--VSSMDASRQLMLNEEQLEDMRQELV- 1595
+ E+ + DK + + E+ +D RQ+ N E+ + +L+
Sbjct: 1406 -------QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458
Query: 1596 -------RQYQEHQQATELLRQAHMRQMERQREDQEQLQ--EEIKRLNRQLAQRSSIDNE 1646
R +E +A R+ + + R +E L+ EE +R N+QL D E
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA----DME 1514
Query: 1647 NLVSERERV--LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQG--EVEEQTFK- 1701
+L+S ++ V + ELE K+ E++ +L + Q + + EV Q K
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 1702 --EKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDR 1759
E++L + E + RLL + +V + A +E+ + L +
Sbjct: 1575 QFERDLQTRDEQ-------------NEEKKRLL--IKQVRELEAELEDERKQRALAV--- 1616
Query: 1760 SSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGT 1819
+SK + L + EA +++ + DE I K+ +
Sbjct: 1617 ASKKKMEIDL---KDLEAQIEAA-----NKARDEVIKQLR-------------KLQAQMK 1655
Query: 1820 ELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELM 1879
+ + L + + EI +++E + S L+A + +L E ++ + HA+ + EL
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKS-LEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 1880 RESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ 1939
E + L + L R+ ++ E+L E S E L + +
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARI---AQLEEELEEEQSNME-----------LLNDRFR 1760
Query: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQIQEE-RELLSRQKE--------------AMK 1984
+ T +D L EL + Q+ + +QQ++ + +EL ++ +E A++
Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820
Query: 1985 AEAGPVEQQLLQE-------------TEKLMKEKL----EVQCQAEKVRDDLQK------ 2021
A+ G +E+QL QE TEK +KE + + A++ ++ ++K
Sbjct: 1821 AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880
Query: 2022 QVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Q+K + EE+ +R ++ EL D + N+ L +++ ++ L
Sbjct: 1881 QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRL 1928
Score = 56.6 bits (135), Expect = 5e-07
Identities = 84/384 (21%), Positives = 165/384 (42%), Gaps = 48/384 (12%)
Query: 3345 LKELQKQLEEKHSRIVELLNETEKY-----KLDSLQTR-QQMEKDRQVHRKTLQTEQEAN 3398
L ++ +Q EE ++ ELL EK +L+ ++ + QQ+ +++ + + LQ E E
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 3399 TEGQK-------KMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451
E ++ K EL+ + DL+ ++EE+ ++ L E +++Q +Q+ ++Q E E
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 3452 EKRESRRI-------LYQNLNEPTTWSLTSDRTRNWVLQQKI-------------EGETK 3491
R+ ++ + + E L D+ ++ ++K+ E E K
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEIL--LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 3492 ESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFI-WV 3550
N AK+ + + ++L+ Q L +KA +L ET D +D I +
Sbjct: 1022 AKNLAKIRNKQ------EVMISDLEERLKKEEKTRQEL-EKAKRKLDGETTDLQDQIAEL 1074
Query: 3551 QENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLR 3610
Q IDE+ LQL K ++ E ++ L+ EL I++L E+ +
Sbjct: 1075 QAQIDELKLQLAK---KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 3611 NMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE 3670
K E+Q R + +L+ A + + ++ K L++ K E
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Query: 3671 AEVYKLKAELRNDSLLQTLSPDSE 3694
A++ ++ R+ + L+ LS E
Sbjct: 1192 AQIQDMRQ--RHATALEELSEQLE 1213
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 157 bits (398), Expect = 1e-37
Identities = 391/1990 (19%), Positives = 824/1990 (41%), Gaps = 324/1990 (16%)
Query: 1032 EGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESS-LRATQPS 1090
+G+++ + E++++V K S + + + +L+ + V +E LR S
Sbjct: 334 DGNINLTELTLALENELLVT-KNSIHQAALASFKAEIRHLLERVDQVVREKEKLR----S 388
Query: 1091 ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEEL 1150
+ DK +K +++ SE +D +E + + ++ E + + +LK EL
Sbjct: 389 DLDKAEKLKSLMASEVDDHHAAIERRN-----------EYNLRKLDEEYKERIAALKNEL 437
Query: 1151 IFAQEEKIKELQKIH---QLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLC 1207
+E+ +++ K + E++ KT+E + L L + + + +E L
Sbjct: 438 RKEREQILQQAGKQRLELEQEIEKAKTEENYIRDR-LALSLKENSRLENE-----LLENA 491
Query: 1208 SVLGEYYTPALKCEVNAED--KENSGDYISENEDPELQDYRYEVQ--DFQENMHTLLNKV 1263
L EY K + N E+ E GD + + LQ+ R +++ L ++V
Sbjct: 492 EKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQV 551
Query: 1264 TEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF------------------- 1304
E LQ+ L + Q G L +N P EE E
Sbjct: 552 DE-------LQSELEEYRAQ---GRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPL 601
Query: 1305 -LSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEA 1363
+SI +++ +E + H + L+ + K+ ++L+ + S ++ + +Q +E
Sbjct: 602 NMSIEAELV-IEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
Query: 1364 EIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVK 1423
E H L+K++ + L + V+ E+ + T KK + +E +
Sbjct: 661 ETHTLEKQISDLKNEIA--ELQGQAAVLKEAHHEATCRHEE-EKKQLQVKLE-------E 710
Query: 1424 EETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQ 1483
E+T++ + L Q++ +L+ + + Q R G +++A +++ Q
Sbjct: 711 EKTHLQEKLRLQHEMELKARLTQA----------QASFEREREGLQSSAWTEEKVRGLTQ 760
Query: 1484 EQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH----DIP 1539
E F++ +L+ + T E +++ KE + +EL E G+E + + + +
Sbjct: 761 ELEQFHQEQLT-SLVEKHTLEKEELR-KELLEKHQRELQE-GREKMETECNRRTSQIEAQ 817
Query: 1540 ESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQ 1599
DC ++E S QS+ D Q + Q E + EL Q
Sbjct: 818 FQSDC-QKVTERCES------ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT---Q 867
Query: 1600 EHQQATELLRQAHMRQMERQ---REDQEQLQEEIK-RLNRQLAQRSSI--DNENL--VSE 1651
E +A ELL++ R+ +++E L++ K LN + +R + D E+L VSE
Sbjct: 868 ECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSE 927
Query: 1652 RERVLLE----ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDR 1707
++ LL EL++ + L RE++ C Q G Q + E E D+
Sbjct: 928 TQQSLLSDQILELKSSHKRELREREEVLC---------QAGASEQLASQRLERLEMEHDQ 978
Query: 1708 KPEDVPPEILSNE---RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQ 1764
+ +++ ++L+ E + + A+ ++ E+ + + ++E + S Q
Sbjct: 979 ERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKE-----MQQATSPLSMLQ 1033
Query: 1765 SSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQR 1824
S +I E E D + + ++ EE ++
Sbjct: 1034 SGCQVIGEEEVE------------------------GDGALSLLQQGEQLLEENGDVLLS 1069
Query: 1825 LVRSGFAGTEIDPENEELMLNISSRLQAAVEKL------LEAISETSSQLEHAKVTQTEL 1878
L R A + EN ++ I SRLQ ++KL + E +++ QTE
Sbjct: 1070 LQR---AHEQAVKENVKMATEI-SRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEP 1125
Query: 1879 MRESFRQKQ-------EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEK 1931
+ R KQ L+ +E+R+ + + ++ V++ ++E ++G+++ +
Sbjct: 1126 FLQQNRTKQVEGVTRRHVLSDLE-DDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELE 1184
Query: 1932 TLFERQIQ--EKTDIIDRLEQEL--LC-----ASNRLQELEAEQQQIQEERELLSRQKEA 1982
E + + E + I +L+++L LC AS + Q+L + ++++ ++L R EA
Sbjct: 1185 NSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEA 1244
Query: 1983 -----MKAEAGPVEQQLLQETEKLMKEKL--------EVQCQAEKVRDDLQKQVKALEID 2029
+ E E LQE ++M+ + E+ + +++D+L+K
Sbjct: 1245 SPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKK-------- 1296
Query: 2030 VEEQVSRFIELEQ---EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQE 2086
+EE F+ LE+ E E +L L+ ++EK+++ + ++ E + E
Sbjct: 1297 MEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLE 1356
Query: 2087 IQ------KLEQQL-KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDI 2139
I+ +L Q L + VPR + + H E +Q +L+ T LL K + +I
Sbjct: 1357 IEPDGNILQLNQTLEECVPRVRSV-HHVIEECKQENQYLEGNTQ-----LLEKVK-AHEI 1409
Query: 2140 QERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLE-VQLQ------ 2192
+ I+ + R R Q +L T +D KHF EL LE +LQ
Sbjct: 1410 AWLHGTIQTHQERPRVQNQVILEENTTLLGFQD-KHFQHQATIAELELEKTKLQELTRKL 1468
Query: 2193 AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK 2252
ER I K+K++ + E+ E+ + + + ++ ++E+ + ES ++L+QEN
Sbjct: 1469 KERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES----EKLQQENS 1524
Query: 2253 LFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK--- 2309
+ ++++ L E D++S L G ++ Q+ E + Q N V K+ + LK
Sbjct: 1525 ILRNEITTL----NEEDSISNLKLGTLNGSQEEMWQKTET-VKQENAAVQKMVENLKKQI 1579
Query: 2310 ---------ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2360
+ +N + +KN ++ ++ +++ C ++E E N +E+ +
Sbjct: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLC-----QKEKEPGNSALEERE 1634
Query: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2420
QE N+ ++ S SL+ +L V + ++Q+ +E+ MK + + +
Sbjct: 1635 QEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPD 1694
Query: 2421 FKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDK-PELEVVLTEDALKSLEN 2479
++ Q++ S+ E + K + +N +D L+K E + + KS E+
Sbjct: 1695 --LSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEH 1752
Query: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
Q+ + K ++ + ++ LE TV +L++++ ++ Q+ E E L+++
Sbjct: 1753 QS------ASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ----EKEALKQE 1802
Query: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYA-KFCQDNQTISSEPERTNIQNLNQLREDELG 2598
+++L K Q+Q + +A + + ++ +R + L+ L +E
Sbjct: 1803 VMSLHK------------QLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQ- 1849
Query: 2599 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLL---------ELQKL 2649
L L++ V L +E+V E N+L K +K L E +KL
Sbjct: 1850 ---QLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL 1906
Query: 2650 LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYK 2709
E Q +KE+ + + V + + + ELE + E+ K
Sbjct: 1907 SLKRECDQFQKEQSPANRKVSQMNSLEQ------------ELETIHLEN-------EGLK 1947
Query: 2710 EKAEKLQEELL-VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE 2768
+K KL E+L+ ++ T+ D ++ ++ +E ++Q ++ E
Sbjct: 1948 KKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ--RQLLQAE 2005
Query: 2769 PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI 2828
+ L + + ++T T + + +++ I++ + + + E ++Q E++
Sbjct: 2006 RINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQL 2065
Query: 2829 EK-------MQELHAAEILDMESRHISE--TETLKREHYVAVQLLKEECGTLKAVIQCLR 2879
K +++L+ +++ ++E +T ++++Y LL+E+ +L +++ L
Sbjct: 2066 CKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNY----LLEEKIASLSNIVRNLT 2121
Query: 2880 SKEGSSIPEL 2889
+S P L
Sbjct: 2122 PAPLTSTPPL 2131
Score = 148 bits (373), Expect = 1e-34
Identities = 401/1989 (20%), Positives = 803/1989 (40%), Gaps = 273/1989 (13%)
Query: 666 QIDGLQNEMSQKIETMQFEKD-NLITKQNQLILE----ISKLKDLQQSLVNSKSEEMTL- 719
Q +G++N + ++ + F D N+ + L LE ++K Q +L + K+E L
Sbjct: 315 QEEGIENSQ-EILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLL 373
Query: 720 -QINELQKEIEILRQE----EKEKGTLEQEVQELQLKTELL-EKQMKEKENDLQEKFAQL 773
+++++ +E E LR + EK K + EV + E E +++ + + +E+ A L
Sbjct: 374 ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433
Query: 774 EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK 833
+ N + K+ ++ L+ K + QE K+K++++ + + ++EN L+
Sbjct: 434 K--NELRKEREQILQQAGKQRLELEQEIE-------KAKTEENYIRDRLALSLKENSRLE 484
Query: 834 QQCIQLNEEIEKQRNTFSFAEKNFE----VNYQELQEEYACLLKVKDDLEDSKNKQELEY 889
+ ++ E++ + N + ++N E + +L A ++ L +N+ E +
Sbjct: 485 NELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 544
Query: 890 K---SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946
+ ++ L EL R +++ K +E +E E L
Sbjct: 545 RVLQDQVDELQSELEEYRAQGRVLRLPL------KNSPSEEVE----ANSGGIEPEHGLG 594
Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISF-----LNEEVKSLKQEKEQVSLRCRELEIII 1001
+ L +S + EQ+K++H L ++V+ +++ ++ + C++ + +
Sbjct: 595 SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENM 654
Query: 1002 NHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061
+ + Q+S L + + + + A V K E+ E
Sbjct: 655 KQRHENETHTLEKQISDLKNEIAELQGQAA------VLKEAHHEATCRHE---------- 698
Query: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICL- 1120
EE KQ Q+ L+ T E +LQ E+ LK+ + E +R L
Sbjct: 699 -EEKKQLQVKLEE----------EKTHLQEKLRLQHEME-LKARLTQAQASFEREREGLQ 746
Query: 1121 -SLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179
S V + + +E + L SL E+ +EE KEL + HQ ELQ + + +
Sbjct: 747 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
Query: 1180 EGKPLHLLIGKLQ---KAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE 1236
+ + + Q + V+E C LQ+ L Y LK ++ + +E + E
Sbjct: 807 CNRRTSQIEAQFQSDCQKVTERCESALQS----LEGRYRQELK-DLQEQQREEKSQW--E 859
Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR--LSKIWGQQTDGMKLEFGE 1294
E EL E + QE + L + E+ L++ Q R L K + + + M +E +
Sbjct: 860 FEKDELTQ---ECAEAQELLKETLKR--EKTTSLVLTQEREMLEKTYKEHLNSMVVERQQ 914
Query: 1295 ENLPKEETEFLSIHSQMTNLED----IDVNHKSKLSSLQD-LEKTKLEEQV--QELESLI 1347
E+ +S +Q + L D + +HK +L ++ L + EQ+ Q LE L
Sbjct: 915 LLQDLEDLRNVS-ETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLE 973
Query: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK 1407
Q+ +E A + + + S + + + Q+ P S ++
Sbjct: 974 MEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQ 1033
Query: 1408 KNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG 1467
+ GE V+ + + L Q EQL EE V++S+ A Q
Sbjct: 1034 SG----CQVIGEEEVEGDGALSLL---QQGEQLLEENGDVLLSLQRAHEQAV-------- 1078
Query: 1468 KENTASSKQAHAVCQQEQHYFNEMKLSQ--DQIGFQTFETVDVKFKEEFKPL-----SKE 1520
KEN + + + Q+ Q + +S D+ + F E+ +P +K+
Sbjct: 1079 KENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNT----AEQTEPFLQQNRTKQ 1134
Query: 1521 LGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQL 1580
+ + +LS+ + ++ ++ S + + RQ + E S +S++ +L
Sbjct: 1135 VEGVTRRHVLSDLEDDEV-----------RDLGSTGTSSVQRQEVKIEESEASVEGFSEL 1183
Query: 1581 MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR 1640
N E+ EL Q + Q+ +L +R E ++ L ++ L ++L
Sbjct: 1184 E-NSEETRTESWELKNQISQLQEQLMML----CADCDRASEKKQDLLFDVSVLKKKLKML 1238
Query: 1641 SSIDNENLVSERERVLLEELEALKQLSLAGREKLCC--ELRNSSTQTQNGNENQGEVEEQ 1698
I S + ++L E++ RE C ELR T+ EN E+ +
Sbjct: 1239 ERIPE---ASPKYKLLYEDV---------SRENDCLQEELRMMETRYDEALENNKELTAE 1286
Query: 1699 TFKEKELDRKPEDVPPEILSNER-YALQKANNRLLKILLEVVKTTAAVEETIGRHVLGIL 1757
F+ ++ +K E+V LS E+ Y K N L +L V++ +E+
Sbjct: 1287 VFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVL--VLRLQGKIEKL--------- 1335
Query: 1758 DRSSKSQSSASLIWRSEAEASVKSCVHE------EHTRVTDESIPSYSGSDMPRNDINMW 1811
+ S Q +W EAS+++ E + + +E +P +
Sbjct: 1336 -QESVVQRCDCCLW----EASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE 1390
Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH- 1870
++ E T+L +++ A + + + + Q +E+ + +H
Sbjct: 1391 NQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQN--QVILEENTTLLGFQDKHFQHQ 1448
Query: 1871 AKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930
A + + EL E T+ + +L+ER+ + ++ L+ + E + +
Sbjct: 1449 ATIAELEL---------EKTKLQELTRKLKERVTILVKQKDVLS--HGEKEEELKAMMHD 1497
Query: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
+ ++Q+K +++ R E E L N + L E + EE + + + +
Sbjct: 1498 LQITCSEMQQKVELL-RYESEKLQQENSI--LRNEITTLNEEDSISNLKLGTLNGS---- 1550
Query: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
++++ Q+TE + +E VQ K+ ++L+KQ+ L+I ++ EL Q+ +
Sbjct: 1551 QEEMWQKTETVKQENAAVQ----KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEK 1606
Query: 2051 LRQQNQALEKQLEKMRKFLDEQAI-DREHERDVFQQEIQ--KLEQQLKVVPRFQPISE-- 2105
L++ NQ L + L + K A+ +RE E+ ++E++ K++ V +SE
Sbjct: 1607 LQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVK 1666
Query: 2106 HQTREVEQLANHLKEKTDKCSEL-----LLSKEQLQRDIQERNEEI--------EKLEFR 2152
QT V+Q + LK++ +K +L L +Q + NE++ E+L
Sbjct: 1667 IQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSC 1726
Query: 2153 VRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2212
V +L ++ L+ +++K + A SL+ QL A ++ + E + N+ Q+
Sbjct: 1727 VDKLAKSSLLEHRIATMKQEQKSWEHQSA----SLKSQLVASQEKVQNLEDTVQNVNLQM 1782
Query: 2213 EQFREEL-------ENKNEEVQQLHMQLE-----IQKKESTTRLQELEQENKLFKDDMEK 2260
+ + +L E +EV LH QL+ E T L + K D K
Sbjct: 1783 SRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWD--K 1840
Query: 2261 LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL---------KIT 2311
L + E + Q+ + ++Q + E+ E+V +L+ L
Sbjct: 1841 LDHLMNEEQQLLWQENE----RLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSG 1896
Query: 2312 TDNKVIEEKNELIRDLET-QIECLMSDQECVKRNR-EEEIEQLNEVIEKLQQELANIGQK 2369
T N +EK L R+ + Q E ++++ + N E+E+E ++ E L+++ + ++
Sbjct: 1897 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ 1956
Query: 2370 TSMNAHSLSEEADS-LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
H S S H D+ + ++ A E+ ++ L + ++NQ Q
Sbjct: 1957 LMEMQHLRSTATPSPSPHAWDLQLLQQQACPM---VPREQFLQLQRQLLQAE-RINQHLQ 2012
Query: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2488
E L+ Q E V V + + + + +L++V K L + + E+
Sbjct: 2013 E--ELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLV------KRLLQEKVNQLKEQ 2064
Query: 2489 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
K + + + L +E+ K LE+T+ Q+ + + +L++KI +L IV
Sbjct: 2065 LCKNTKADAMVKDLYVENAQLLKALEVTE------QRQKTAEKKNYLLEEKIASLSNIVR 2118
Query: 2549 EKVAAALVS 2557
A L S
Sbjct: 2119 NLTPAPLTS 2127
Score = 148 bits (373), Expect = 1e-34
Identities = 384/1953 (19%), Positives = 780/1953 (39%), Gaps = 306/1953 (15%)
Query: 1816 EEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA-ISETSSQLEHAKVT 1874
EEG E SQ ++++ + + EL L + + L + +A ++ +++ H
Sbjct: 316 EEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLER 375
Query: 1875 QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD----- 1929
+++RE +E+LR L + + + +A E+ I+ +
Sbjct: 376 VDQVVRE--------------KEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRK 421
Query: 1930 -EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988
++ ER K ++ EQ L A + ELE E ++ + E + + E
Sbjct: 422 LDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENS 481
Query: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048
+E +LL+ EKL E + K++ +L+ + D++ + F L++E+ T++
Sbjct: 482 RLENELLENAEKL----AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF-LQEERLTQM 536
Query: 2049 M-DLRQQNQALEKQLEKMRKFLDEQAIDR----------------------EHERDVFQQ 2085
+ +Q + L+ Q+++++ L+E E E + +
Sbjct: 537 RNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSE 596
Query: 2086 EIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT----DKCSELLLSKEQLQRDIQE 2141
E L ++ + + E R++ L L++K + E ++S ++ Q ++++
Sbjct: 597 ECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQ 656
Query: 2142 RNE-EIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPE-LSLEVQLQAERDAID 2199
R+E E LE ++ +L+ + +++ H + E L+V+L+ E+ +
Sbjct: 657 RHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ 716
Query: 2200 RK---------EKEITNLEEQLEQFREELENK---NEEVQQLHMQLEIQKKESTTRLQEL 2247
K + +T + E+ RE L++ E+V+ L +LE +E T L E
Sbjct: 717 EKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE- 775
Query: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEID-QLNEQVTKLQQ 2306
++ L K+++ K L K + +QE +++ + N + ++++
Sbjct: 776 --KHTLEKEELRK-----------------ELLEKHQRELQEGREKMETECNRRTSQIEA 816
Query: 2307 QLKITTDNKVIEEKNELIRDLE----TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362
Q + + KV E ++ LE +++ L Q K E E ++L + + Q+
Sbjct: 817 QFQ-SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL 875
Query: 2363 LANIGQKTSMNAHSLSEEADSL----KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2418
L ++ + L++E + L K L+ ++ E+ L Q +E +++L +
Sbjct: 876 LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 935
Query: 2419 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2478
Q+ + S KRE E++ S +A L + + E + E K L
Sbjct: 936 ------QILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
Query: 2479 NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2538
+ K+ E + T + +L+S +IK+MQ Q MLQ
Sbjct: 990 MENIHKATCETADRERAEMSTEISRLQS--------------KIKEMQ-QATSPLSMLQS 1034
Query: 2539 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2598
Q I EE+V L +Q+ + ++N + +R + Q + + ++
Sbjct: 1035 ---GCQVIGEEEVE----GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE--NVKMA 1085
Query: 2599 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ--KLLEG---- 2652
++IS L R+ +LE +V S L++ E N E+ + L+ K +EG
Sbjct: 1086 TEISRLQQRLQKLEPGLV---MSSCLDEPATEFF-GNTAEQTEPFLQQNRTKQVEGVTRR 1141
Query: 2653 ---NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYK 2709
++ + E S V + ++ S F+ELE S T+ E K
Sbjct: 1142 HVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELE----NSEETRTESWELK 1197
Query: 2710 EKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET--------EVQES 2761
+ +LQE+L++ + + + ++ K+KL +LE+ E E
Sbjct: 1198 NQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSR 1257
Query: 2762 KKACMFEPLPI-------------KLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINL 2808
+ C+ E L + +L+ + D K+ +T L K+
Sbjct: 1258 ENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYD----- 1312
Query: 2809 QSECSSEEVTEIISQFTEKIEKMQE---------LHAAEILDME----------SRHISE 2849
+ + +EE+ ++ + KIEK+QE L A + ++E ++ + E
Sbjct: 1313 EVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEE 1372
Query: 2850 TETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDW 2909
R + ++ K+E L+ Q L + I W
Sbjct: 1373 CVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIA---------------------W 1411
Query: 2910 GQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGE 2969
G TH + + ++ EE+ + K + H + L L E
Sbjct: 1412 LHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQ------HQATIAELEL--------E 1457
Query: 2970 DHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE-VYDSSQSHESFSDWRGELLL 3028
+Q+++ L+ER + + KD+++ + + E + + Q S + ELL
Sbjct: 1458 KTKLQELTRK-LKER---VTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLR 1513
Query: 3029 ALQQVFLEERSVLLAAFRTELTALGTTDAV-----GLLNCLEQRIQEQGVEYQAAMECLQ 3083
+ +E S+L R E+T L D++ G LN ++ + ++ + +Q
Sbjct: 1514 YESEKLQQENSIL----RNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1569
Query: 3084 KADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSM 3143
K ++ L Q++ KI + Q+ + + EL + N Q Q ++ E+ L+ M
Sbjct: 1570 KM--------VENLKKQISELKI---KNQQLDLENTELSQKN-SQNQEKLQELNQRLTEM 1617
Query: 3144 -----KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
K+ E+ EK LK EL + K++ T + + L E+ +++
Sbjct: 1618 LCQKEKEPGNSALEEREQEKF---NLKEELERCKVQSSTLVSSLEAELSEV---KIQTHI 1671
Query: 3199 KTDEVHLLNDTLASEQKKSR--ELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN 3256
E HLL D L ++ R +L +K + L +E+ KE+ E L L S +
Sbjct: 1672 VQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK-EALSEELNSCVDK- 1729
Query: 3257 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
L + LLE + + + Q+ E Q +QL Q + L+ +++ +++ M S L
Sbjct: 1730 LAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL 1789
Query: 3317 ---DRERE--------LHAQLQSSDGTGQSRPPLPS-----------------EDLLKEL 3348
+E+E LH QLQ++ G + P + + + L+ E
Sbjct: 1790 RVTQQEKEALKQEVMSLHKQLQNAGGKSWA-PEIATHPSGLHNQQKRLSWDKLDHLMNEE 1848
Query: 3349 QKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD-RQVHRKTLQTEQEANTEGQKKMHE 3407
Q+ L +++ R+ ++ T+ S + +Q+E + H+K L N Q+K+
Sbjct: 1849 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL-S 1907
Query: 3408 LQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP 3467
L+ + + Q++ ++V +++ Q L+ I E + + +++ K + + + Q+L
Sbjct: 1908 LKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLK-KKQVKLDEQLMEMQHLRST 1966
Query: 3468 TTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQ 3527
T S + +LQQ+ + +L N L+ ++L+ S+
Sbjct: 1967 ATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQ---EELENRTSETN 2023
Query: 3528 VLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTER 3587
PQ E Q T +E I V++ + + LQ+ Q E+ + +T ++ +
Sbjct: 2024 T-PQGNQE--QLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ---LCKNTKADAMVKD 2077
Query: 3588 LLRQNAELTGHISQLTEEKNDLRNMVMKLEEQI 3620
L +NA+L + + + LEE+I
Sbjct: 2078 LYVENAQLLKALEVTEQRQKTAEKKNYLLEEKI 2110
Score = 145 bits (367), Expect = 6e-34
Identities = 384/1975 (19%), Positives = 799/1975 (40%), Gaps = 353/1975 (17%)
Query: 213 NLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT 272
N Q+ + D ++ + LTE + L+ + +NS H + A K +I
Sbjct: 321 NSQEILKALDFSLDGNINLTELTLALENELL------VTKNSIHQAALASF---KAEI-- 369
Query: 273 HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIE 332
+ LE D ++ + +K + D +++ +K+++ E+ + IE
Sbjct: 370 -RHLLERVDQVVREKEKLRSD----------------LDKAEKLKSLMASEVDDHHAAIE 412
Query: 333 ---ELNTKIIEEEKKT--LELKDKLTTA-DKLLGELQEQIVQKNQEIKNMKLELTNSKQK 386
E N + ++EE K LK++L +++L + +Q ++ QEI+ K E + +
Sbjct: 413 RRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDR 472
Query: 387 ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDE------M 440
S +E +L EL + K +++E ++ ++++ + L + +LD +
Sbjct: 473 LALSLKENSRLEN---ELLENAEKLAEYE-NLTNKLQRNLENVLAEKFGDLDPSSAEFFL 528
Query: 441 YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI 500
+++ QM+ E RQ +++ E+++ L Y Q +++ + + N
Sbjct: 529 QEERLTQMRNEYERQCRVLQDQVD-----ELQSELEEY------RAQGRVLRLPLK--NS 575
Query: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIA---EQESK 557
++ + ++ E GL EE L +E EL + + Q R E E K
Sbjct: 576 PSEEVEANSGGIEPEHGLGSEECNPLNMSIE---AELVIEQMKEQHHRDICCLRLELEDK 632
Query: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE------KNAVL 611
+ K L +VS ++++ ++ +HE E + ++ L+ E + AVL
Sbjct: 633 VRHYEKQLDET------VVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVL 686
Query: 612 DRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQ 671
E + QL EEE + L+E L ++H + ++ ++++ +GLQ
Sbjct: 687 KEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQ 746
Query: 672 NE---------MSQKIETMQFEKDNLITKQNQLILEISKLK----DLQQSLVNSKSEEMT 718
+ ++Q++E QF ++ L + + LE +L+ + Q + E+M
Sbjct: 747 SSAWTEEKVRGLTQELE--QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKME 804
Query: 719 LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778
+ N +IE Q + +K T E+ LQ +++K+ + +E+ +Q E E
Sbjct: 805 TECNRRTSQIEAQFQSDCQKVT-ERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKD 863
Query: 779 ILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ 838
L E +++LK + +E+ + + + + + +++ + ++ E + L Q
Sbjct: 864 ELTQECAEAQELLK--ETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLED 921
Query: 839 LNEEIEKQRNTFSFAEKNFEVNY-QEL--QEEYACLLKVKDDLEDSK-NKQELEY-KSKL 893
L E Q++ S + ++ +EL +EE C + L + + E+E+ + +
Sbjct: 922 LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 981
Query: 894 KALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTE---LMEKLEVTKR 950
+ +++ L ++ I+ T + E T ++ + +++ T+ L +V
Sbjct: 982 EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1041
Query: 951 EKLELSQRLSDL--SEQLKQKHGEISF---------------LNEEVKSLKQEKEQ---- 989
E++E LS L EQL +++G++ + E+ L+Q ++
Sbjct: 1042 EEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
Query: 990 -VSLRC-------------RELEIIINHNRAENVQSCDTQ--VSSLLDGVVTMTSRGAEG 1033
V C + E + NR + V+ + +S L D V
Sbjct: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1161
Query: 1034 SVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL-------RA 1086
SV + EES+ VE EN EE++ E L + S +E + RA
Sbjct: 1162 SVQRQEVKI-EESEASVEGFSELEN---SEETRTESWELKNQISQLQEQLMMLCADCDRA 1217
Query: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVY---STHVDQVRE---YMENEKD 1140
++ ++ L +++VLK + L EA L+Y S D ++E ME D
Sbjct: 1218 SEKKQD--LLFDVSVLKKKLKMLERIPEASP-KYKLLYEDVSRENDCLQEELRMMETRYD 1274
Query: 1141 KALCSLKE--ELIFAQEEKIKELQKIHQLELQTMKT-QETGDEGKPLHLLIGKLQKAVSE 1197
+AL + KE +F ++++K+++++ + L K+ E E + L++L+ +LQ + +
Sbjct: 1275 EALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEK 1334
Query: 1198 ECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED-----PELQDYRYEVQDF 1252
+Q L E L+ E + G+ + N+ P ++ + +++
Sbjct: 1335 LQESVVQRCDCCLWEASLENLEIEPD-------GNILQLNQTLEECVPRVRSVHHVIEEC 1387
Query: 1253 -QENMHTLLNKVTEEYNKLLVLQTRLSKI-WGQQTDGMKLEFGEENLPKEETEFLSIHSQ 1310
QEN + E N L+ + + +I W T ++ +E + L ++
Sbjct: 1388 KQENQYL-------EGNTQLLEKVKAHEIAWLHGT----IQTHQERPRVQNQVILEENTT 1436
Query: 1311 MTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLK-----ETEQNYEAEI 1365
+ +D H++ ++ L +LEKTKL+E ++L+ ++ L +Q E E+ +A +
Sbjct: 1437 LLGFQDKHFQHQATIAEL-ELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMM 1495
Query: 1366 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNID-------------G 1412
H LQ + + V + ++++ S ++ I G
Sbjct: 1496 HDLQITCSEMQQ----------KVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLG 1545
Query: 1413 TIEFSGEFGVKEETNIVKLLEKQYQ---EQLEEEVAKVIVSMSIAFAQQTELSRISG--- 1466
T+ S E + ++T VK Q E L+++++++ + + TELS+ +
Sbjct: 1546 TLNGSQE-EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 1604
Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF---QTFETVDVKFKEEFKPLSKELGE 1523
K + + +CQ+E+ N ++Q F + E V+ L EL E
Sbjct: 1605 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE 1664
Query: 1524 HG-------------KEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS 1570
K+ L H P+ D IS + +K ++++ +E++
Sbjct: 1665 VKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELN 1724
Query: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630
S +D + L E ++ M+QE ++ EHQ A + Q+ +E + L++ +
Sbjct: 1725 -SCVDKLAKSSLLEHRIATMKQE--QKSWEHQSA------SLKSQLVASQEKVQNLEDTV 1775
Query: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNE 1690
+ +N Q+++ S D E+E + E + KQL AG + E+ + N
Sbjct: 1776 QNVNLQMSRMKS-DLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHN--- 1831
Query: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
+++ +LD +++ E+ L + N RL
Sbjct: 1832 -----QQKRLSWDKLD--------HLMNEEQQLLWQENERL------------------- 1859
Query: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810
+++ ++AE + H+R E + + +P++ ++
Sbjct: 1860 ----------------QTMVQNTKAELT--------HSR---EKVRQLESNLLPKHQKHL 1892
Query: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870
T TE + ++ E D +E Q+ + + ++ +LE
Sbjct: 1893 NPSGTMNPTEQEKLSLK-----RECDQFQKE---------QSPANRKVSQMNSLEQELE- 1937
Query: 1871 AKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA-----VELSKAEGVID 1925
L E ++KQ +K E+L E H S A + ++L + +
Sbjct: 1938 ----TIHLENEGLKKKQ-----VKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPM 1988
Query: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ---IQEERELLSRQKEA 1982
++ +RQ+ + I L++EL ++ + Q+Q + EER + QK
Sbjct: 1989 VPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLK 2048
Query: 1983 MKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ----VKALEIDVEEQ 2033
+ ++LLQE +KE+L +A+ + DL + +KALE+ + Q
Sbjct: 2049 L-------VKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQ 2096
Score = 134 bits (338), Expect = 1e-30
Identities = 342/1596 (21%), Positives = 684/1596 (42%), Gaps = 214/1596 (13%)
Query: 2207 NLEEQLEQFREE-LENKNEEVQQLHMQLE--IQKKESTTRLQELEQENKLFKDDMEKLGL 2263
++E L+ ++EE +EN E ++ L L+ I E T L E E + K+ + + L
Sbjct: 306 SVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLAL---ENELLVTKNSIHQAAL 362
Query: 2264 AIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK--VIEEKN 2321
A + + +H+L + Q+++EKE L ++ KL+ + D+ IE +N
Sbjct: 363 A-----SFKAEIRHLL-ERVDQVVREKEKLRSDL-DKAEKLKSLMASEVDDHHAAIERRN 415
Query: 2322 EL-IRDLETQI-ECLMSDQECVKRNREEEIEQ-------LNEVIEKLQQELANIGQKTSM 2372
E +R L+ + E + + + +++ RE+ ++Q L + IEK + E I + ++
Sbjct: 416 EYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLAL 475
Query: 2373 --------------NAHSLSEE---ADSLKHQLDVVIAEKLA----LEQQVETANEEMTF 2411
NA L+E + L+ L+ V+AEK + E +T
Sbjct: 476 SLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQ 535
Query: 2412 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP-ENSVNVAIDHLSKD-KPELEVVL 2469
M+N + + EL S E + ++ +P +NS + ++ S +PE +
Sbjct: 536 MRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGS 595
Query: 2470 TE--DALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ----CYKQIK 2523
E S+E + + +E I L L+LE V + +L + C K +
Sbjct: 596 EECNPLNMSIEAELVIEQMKEQHHRDICCLR---LELEDKVRHYEKQLDETVVSCKKAQE 652
Query: 2524 DMQEQGQFETEMLQKKIVNLQ-KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPE 2582
+M+++ + ET L+K+I +L+ +I E + AA++ + EA + + + Q + E E
Sbjct: 653 NMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ-VKLEEE 711
Query: 2583 RTNIQNLNQLRED-EL----------------GSDISALTL-RISELESQVVEMHTSLIL 2624
+T++Q +L+ + EL G SA T ++ L ++ + H
Sbjct: 712 KTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFH----- 766
Query: 2625 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2684
+++ + EK+ LEKE+ EL EK QRE ++ R + E + T+++ E
Sbjct: 767 QEQLTSLVEKHTLEKEELRKELL------EKHQRELQEGREKMETECNRRTSQI-----E 815
Query: 2685 SGFFNELEAL--RAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAE 2742
+ F ++ + + R ES E Y+++ + LQE+ +E + +KD ++ AE
Sbjct: 816 AQFQSDCQKVTERCESALQSLE-GRYRQELKDLQEQQR-EEKSQWEFEKD--ELTQECAE 871
Query: 2743 AKEKLS-ILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLK----ISSSNQTPQI 2797
A+E L L++E T + +++ M E + S+ + L+ + + ++T Q
Sbjct: 872 AQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS 931
Query: 2798 LVKNAGIQINLQSECSSEEVTEIISQF-------TEKIEKMQELHAAE-------ILDME 2843
L+ + +++ + E E++ Q ++++E+++ H E +L ME
Sbjct: 932 LLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME 991
Query: 2844 SRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSS 2903
+ H + ET RE + E L++ I+ ++ + E+
Sbjct: 992 NIHKATCETADRERAE----MSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGD 1047
Query: 2904 DSGSDWGQGIYLTHSQGFDIASEGRG-EESESATDSFPKKIKGLLRAVHN--EGMQVLSL 2960
+ S QG L G + S R E++ +I L + + G+ + S
Sbjct: 1048 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSC 1107
Query: 2961 TESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFS 3020
+ P ++ ++ +Q +EP+L++ + + + +++ ++ + EV D +
Sbjct: 1108 LDEPATEFFGNTAEQ-TEPFLQQNRTKQVEGVTRRHVLSDLE---DDEVRDLGST----- 1158
Query: 3021 DWRGELLLALQQVFLEERSVLLAAF-RTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAM 3079
G + Q+V +EE + F E + T++ L N + Q +QEQ + A
Sbjct: 1159 ---GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQ-LQEQLMMLCA-- 1212
Query: 3080 ECLQKADRRS-LLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3138
+C + ++++ LL ++ L +K+ + P +LL ++ ++ + E
Sbjct: 1213 DCDRASEKKQDLLFDVSVLK-----KKLKMLERIPEASPKYKLLYEDVSRENDCLQEELR 1267
Query: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
+ + D A E ++L++E V L+ EL + + ET L LE EVK
Sbjct: 1268 MMETRYDEALENNKELTAE---VFRLQDELKKMEEVTETFLS--------LEKSYDEVKI 1316
Query: 3199 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258
+ +E+++L L + +K +E +++ L + LE+L+ + LQ
Sbjct: 1317 ENEELNVLVLRLQGKIEKLQES--VVQRCDCCLWEAS------LENLEIEPDGNI---LQ 1365
Query: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3318
LN Q L E ++ S + + E Q Q+L EKV+ E++
Sbjct: 1366 LN-------QTLEECVPRVRSVHHVIEECKQENQYLEGNTQLL---EKVKAHEIAW---- 1411
Query: 3319 ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL--EEKH----SRIVELLNETEKYKLD 3372
LH +Q T Q RP + ++ +L+E L ++KH + I EL E EK KL
Sbjct: 1412 ---LHGTIQ----THQERPRVQNQVILEENTTLLGFQDKHFQHQATIAEL--ELEKTKLQ 1462
Query: 3373 SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE 3432
L + + V +K + + E E + MH+LQ ++Q+++E R + KL E
Sbjct: 1463 ELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQE 1522
Query: 3433 GQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSD-RTRNWVLQQKIEGETK 3491
L+ + L E+ + ++ N ++ W T + N +Q+ +E K
Sbjct: 1523 NSILRN-----EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKK 1577
Query: 3492 ESNYAKL--IEMNGGGTGCNHELEMIRQKLQCVASKL-QVLPQKASE--RLQFETADDED 3546
+ + K+ +++ T + + ++KLQ + +L ++L QK E E + E
Sbjct: 1578 QISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEK 1637
Query: 3547 FIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEK 3606
F ++E ++ +Q L E S V T LL+ E + + +
Sbjct: 1638 FN-LKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLS 1696
Query: 3607 NDLRNM--VMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIAS---EKEVWNREKLT 3661
+ + + V+ E++ ++ + NS L + +E IA+ E++ W + +
Sbjct: 1697 DFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSAS 1756
Query: 3662 LQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVT 3697
L+ L ++ +V L+ ++N +L + VT
Sbjct: 1757 LKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVT 1792
Score = 120 bits (302), Expect = 2e-26
Identities = 288/1436 (20%), Positives = 594/1436 (41%), Gaps = 239/1436 (16%)
Query: 157 LEMMESELAGKQHEIE-ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ 215
LE + EL + ++E E NR ++ + ++ + + E+A++ +G Q +LQ
Sbjct: 789 LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848
Query: 216 -QARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI-LTH 273
Q R EK + E ELT++ + Q + ETL+ +T+ L Q ++ + T+
Sbjct: 849 EQQREEKSQWEFEKDELTQECAEAQELLK-----ETLKRE--KTTSLVLTQEREMLEKTY 901
Query: 274 QQQLE----EQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKET 329
++ L E+ LL+D + + Q S L ++I ++++S+K E++E+E
Sbjct: 902 KEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL--------ELKSSHKRELREREE 953
Query: 330 II-----------EELNTKIIEEEKKTLELKDKLT-----------TADKLLGELQEQIV 367
++ + L +E +++ E+ KL TAD+ E+ +I
Sbjct: 954 VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1013
Query: 368 QKNQEIKNMK------------LELTNSKQKER-------QSSEEIKQLMGTVEELQKRN 408
+ +IK M+ ++ ++ E Q E++ + G V +R
Sbjct: 1014 RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRA 1073
Query: 409 HKDSQFETDIVQRMEQETQRKLEQLRAEL----------DEMYGQQIVQMKQELIRQHMA 458
H+ + E + Q++L++L L E +G Q + L +
Sbjct: 1074 HEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTK 1133
Query: 459 QMEEMKTRH-----KGEMENALRSYSNITVNEDQIKLMNVAIN-----------ELNIKL 502
Q+E + RH + + L S +V ++K+ + E +
Sbjct: 1134 QVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTES 1193
Query: 503 QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH 562
+ +Q +L+E+L ++ + + +DL+ ++S +++++ + I E K +
Sbjct: 1194 WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER-IPEASPKYKLLY 1252
Query: 563 KSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622
+ +S D E + E+R + L++ E+T +L+ K+ V + S E
Sbjct: 1253 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL-SLEKSY 1311
Query: 623 ERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQ 682
+ ++ + EEL+ L L+ + IEKL++++ Q+ D E S +E ++
Sbjct: 1312 DEVKIE-----NEELNVLVLRLQGK----IEKLQESV----VQRCDCCLWEAS--LENLE 1356
Query: 683 FEKDNLITKQNQLILE-ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL 741
E D I + NQ + E + +++ + + K E L+ N E + + E L
Sbjct: 1357 IEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLE----KVKAHEIAWL 1412
Query: 742 EQEVQELQLKTELLEKQMKEKENDL---QEKFAQLEAENSILKDEKKTLEDMLKIHTPVS 798
+Q Q + + + + E+ L Q+K Q +A + L+ EK L+++ +
Sbjct: 1413 HGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTR-----K 1467
Query: 799 QEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFE 858
+ER+ L +K K S EKE E+ + DL+ C ++ +++E R
Sbjct: 1468 LKERVTIL--VKQKDVLSHGEKEEELKAMMH-DLQITCSEMQQKVELLR----------- 1513
Query: 859 VNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSS--- 915
++LQ+E + L L + + L KL LN TVK +++
Sbjct: 1514 YESEKLQQENSILRNEITTLNEEDSISNL----KLGTLNGSQEEMWQKTETVKQENAAVQ 1569
Query: 916 -VFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974
+ + K ++E + ++ + TEL +K + + EL+QRL+++ Q +++ G
Sbjct: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG--- 1626
Query: 975 FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGS 1034
N ++ +QEK N E ++ C Q S+L ++S AE S
Sbjct: 1627 --NSALEEREQEK---------------FNLKEELERCKVQSSTL------VSSLEAELS 1663
Query: 1035 VSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDK 1094
K+ ++ +++D++ E+ KQ L P ++ ++ S N+K
Sbjct: 1664 EVKIQTHIVQQENHLLKDEL--------EKMKQ----LHRCPDLSDFQQKISSVLSYNEK 1711
Query: 1095 LQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ 1154
L KE L E N ++ S + + +++ ++ + ++ SLK +L+ A
Sbjct: 1712 LLKEKEALSEELNSC-----VDKLAKSSLLEHRIATMKQEQKSWEHQS-ASLKSQLV-AS 1764
Query: 1155 EEKIKELQKIHQ---LELQTMKTQETGDEGKPLHLLIGKLQK-AVSEECSYFLQTLCSVL 1210
+EK++ L+ Q L++ MK+ L + + +K A+ +E + L +
Sbjct: 1765 QEKVQNLEDTVQNVNLQMSRMKSD----------LRVTQQEKEALKQEVMSLHKQLQNAG 1814
Query: 1211 GEYYTPALKCE---VNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY 1267
G+ + P + ++ + K S D + + E Q E + Q + ++T
Sbjct: 1815 GKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSR 1874
Query: 1268 NKLLVLQTRLSKIWGQQ---------TDGMKLEFGEE--NLPKEETEFLSIHSQMTNLE- 1315
K+ L++ L + T+ KL E KE++ SQM +LE
Sbjct: 1875 EKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQ 1934
Query: 1316 DIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQ----------QQLKETEQNYEAEI 1365
+++ H + ++ KL+EQ+ E++ L S+ Q L++
Sbjct: 1935 ELETIHLENEGLKK--KQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPRE 1992
Query: 1366 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425
LQ + Q + + L + E+ T P ++ + T+ V+++
Sbjct: 1993 QFLQLQRQLLQAERINQHLQEE----LENRTSETNTPQGNQEQLV--TVMEERMIEVEQK 2046
Query: 1426 TNIVKLLEKQYQEQLEEEVAK------VIVSMSIAFAQQTELSRISGGKENTASSK 1475
+VK L ++ QL+E++ K ++ + + AQ + ++ ++ TA K
Sbjct: 2047 LKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKK 2102
Score = 116 bits (291), Expect = 4e-25
Identities = 282/1386 (20%), Positives = 580/1386 (41%), Gaps = 245/1386 (17%)
Query: 7 QKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN--- 63
++K+ +L QF Q + S + + ++++ RK KH +++CN
Sbjct: 752 EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 811
Query: 64 ---EMYINS-----SQRVESTVIP-ESTIMRTLHSGEITSHEQGFSVELESEISTTADDC 114
E S ++R ES + E + L + E+ E E + T +C
Sbjct: 812 SQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT--QEC 869
Query: 115 SSEVNGCSFVMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEE 173
+ ++ K T+L L +E ++ +Y E HL M E ++E+
Sbjct: 870 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKE--------HLNSMVVERQQLLQDLED 921
Query: 174 LNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR-----------REKD 222
L E + + L+ + +++R+ ++ Q A+ Q A +E+
Sbjct: 922 LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQ 981
Query: 223 ETMREFLEL---------TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273
E M + L + T ++ ++ + + ++ +++ +LQ+ Q++
Sbjct: 982 EMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE 1041
Query: 274 QQ--------QLEEQDHLLED------------YQKKKEDFTM--QISFLQEKIK----- 306
++ L++ + LLE+ Q KE+ M +IS LQ++++
Sbjct: 1042 EEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPG 1101
Query: 307 -VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ 365
V D+ ++ E +++ TK +E + L D + LG
Sbjct: 1102 LVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1161
Query: 366 IVQKNQEIKNMKLELTNSKQKERQSSEEIK----QLMGTVEELQKR-------------N 408
VQ+ QE+K + E + E ++SEE + +L + +LQ++
Sbjct: 1162 SVQR-QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1220
Query: 409 HKDSQFETDIVQR-----------------MEQETQRKLEQLRAELDEMYGQ--QIVQMK 449
+D F+ ++++ + ++ R+ + L+ EL M + + ++
Sbjct: 1221 KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENN 1280
Query: 450 QELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK 509
+EL + +E+K +ME ++ ++ + D++K+ N +N L ++LQ +
Sbjct: 1281 KELTAEVFRLQDELK-----KMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQ---GKI 1332
Query: 510 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569
EKL+E + + + C + LE+L E I + QT+ E ++ H +E
Sbjct: 1333 EKLQESV-VQRCDCCLWEASLENLEIE---PDGNILQLNQTLEECVPRVRSVH---HVIE 1385
Query: 570 DLKAEIVSASESRKELELKHEAEVT-----------NYKIKLEMLEKEKNAVL---DRMA 615
+ K E + + LE E+ +++ +++ +E +L D+
Sbjct: 1386 ECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHF 1445
Query: 616 ESQE--AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ-----ID 668
+ Q AELE +T+L +E KLKE + I + K KD L K++ +
Sbjct: 1446 QHQATIAELELEKTKL----QELTRKLKERVTI-----LVKQKDVLSHGEKEEELKAMMH 1496
Query: 669 GLQ---NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ 725
LQ +EM QK+E +++E + L + + L EI+ L + + S+ N K + E+
Sbjct: 1497 DLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-EDSISNLKLGTLNGSQEEMW 1555
Query: 726 KEIEILRQE----EKEKGTLEQEVQELQLKTELLE---KQMKEKENDLQEKFAQL----- 773
++ E ++QE +K L++++ EL++K + L+ ++ +K + QEK +L
Sbjct: 1556 QKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLT 1615
Query: 774 --------EAENSILKD---EKKTLEDMLKIHTPVSQEERLIFLDSIKS--KSKDSVWEK 820
E NS L++ EK L++ L+ V + L++ S K + + ++
Sbjct: 1616 EMLCQKEKEPGNSALEEREQEKFNLKEELE-RCKVQSSTLVSSLEAELSEVKIQTHIVQQ 1674
Query: 821 EIEILIEENEDLKQ--QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKV-KDD 877
E +L +E E +KQ +C L++ +K + S+ EK + +E +C+ K+ K
Sbjct: 1675 ENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1734
Query: 878 L-----------EDSKNKQELEYKSKLKALNEELH-----LQRINPTTVKMKSSVFDEDK 921
L + S Q KS+L A E++ +Q +N +MKS
Sbjct: 1735 LLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSD------ 1788
Query: 922 TFVAETLEMGEVVEKDTTELMEKLEVT--KREKLELSQRLSDLSEQLKQKHGE--ISFLN 977
+ T + E ++++ L ++L+ K E++ S L Q K+ + +N
Sbjct: 1789 --LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMN 1846
Query: 978 EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV----SSLLDGVVTMTSRGAEG 1033
EE + L QE E++ + + + H+R E V+ ++ + L+ TM E
Sbjct: 1847 EEQQLLWQENERLQTMVQNTKAELTHSR-EKVRQLESNLLPKHQKHLNPSGTMNPTEQEK 1905
Query: 1034 -SVSKVNKSFGEES-----KIMVEDKVSFENMTV---GEESKQEQLILDHLPSVTKESSL 1084
S+ + F +E K+ + + E T+ E K++Q+ LD + + L
Sbjct: 1906 LSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDE--QLMEMQHL 1963
Query: 1085 RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQ-VREYMENE----- 1138
R+T +L +L+ + + + + ++ L+ + ++Q ++E +EN
Sbjct: 1964 RSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETN 2023
Query: 1139 ----KDKALCSLKEELIFAQEEKIKEL-----QKIHQLELQTMKTQETGDEGKPLHLLIG 1189
+ L ++ EE + E+K+K + +K++QL+ Q K + K L++
Sbjct: 2024 TPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENA 2083
Query: 1190 KLQKAV 1195
+L KA+
Sbjct: 2084 QLLKAL 2089
Score = 113 bits (283), Expect = 3e-24
Identities = 333/1711 (19%), Positives = 691/1711 (40%), Gaps = 223/1711 (13%)
Query: 103 LESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMES 162
LE+E+ A+ + N + + R + N+L E+ +D S +E Q+ L M +
Sbjct: 483 LENELLENAEKLAEYENLTNKLQRNLE--NVLAEKFGDLDPSSAEFFLQEE--RLTQMRN 538
Query: 163 ELAGK----QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR 218
E + Q +++EL ELEE R L ++ G I
Sbjct: 539 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI----------- 587
Query: 219 REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLE 278
E + + +E+ L + + E ++ H L+ + ++ +++QL+
Sbjct: 588 -EPEHGLG-----SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLD 641
Query: 279 E--------QDHLLEDYQKKKEDFTMQISFLQEKIKVYE------MEQDKKVENSNKEEI 324
E Q+++ + ++ + QIS L+ +I + E + ++EE
Sbjct: 642 ETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK 701
Query: 325 QEKETIIEELNTKIIEEEK--KTLELKDKLTTADKLLGELQEQIVQK---NQEIKNMKLE 379
++ + +EE T + E+ + +ELK +LT A +E + ++++ + E
Sbjct: 702 KQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
Query: 380 LTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE-TDIVQRMEQETQRKLEQLRAELD 438
L Q++ S E L EEL+K + Q E + ++ME E R+ Q+ A+
Sbjct: 762 LEQFHQEQLTSLVEKHTL--EKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQ 819
Query: 439 E------MYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMN 492
+ +Q + RQ + ++E + K + E + E Q L
Sbjct: 820 SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQ-ECAEAQELLKE 878
Query: 493 VAINELNIKL---QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
E L Q+ ++ KE L ++ E+ L + LEDL R + +
Sbjct: 879 TLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL-------RNVSETQQS 931
Query: 550 TIAEQESKLNEAHK-SLSTVEDLKAEIVS----ASESRKELELKHEAEVTNYKIKL---E 601
+++Q +L +HK L E++ + + AS+ + LE++H+ E KL E
Sbjct: 932 LLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME 991
Query: 602 MLEKEKNAVLDRMAESQEAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659
+ K DR E+ RL++++ + LS L+ ++ I E+++ +
Sbjct: 992 NIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQV---IGEEEVEGDG 1048
Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKD----LQQSLVNSK-- 713
+ QQ + L E + ++Q + + + ++ EIS+L+ L+ LV S
Sbjct: 1049 ALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCL 1108
Query: 714 SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKE-----------K 762
E T ++ E Q+ + K + V + ++L + ++++ +
Sbjct: 1109 DEPATEFFGNTAEQTEPFLQQNRTKQV--EGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQ 1166
Query: 763 ENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ-EERLIFL----DSIKSKSKD-- 815
E ++E A +E S L++ ++T + ++ +SQ +E+L+ L D K +D
Sbjct: 1167 EVKIEESEASVEG-FSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLL 1225
Query: 816 ---SVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL----QEEY 868
SV +K++++L E + + L E++ ++ + + E Y E +E
Sbjct: 1226 FDVSVLKKKLKML-ERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELT 1284
Query: 869 ACLLKVKDDLEDSKNKQEL-----EYKSKLKALNEELH--LQRINPTTVKMKSSVFDEDK 921
A + +++D+L+ + E + ++K NEEL+ + R+ K++ SV
Sbjct: 1285 AEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCD 1344
Query: 922 TFVAET-------------LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQL-K 967
+ E L++ + +E+ + V + K E +Q L ++ L K
Sbjct: 1345 CCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQE-NQYLEGNTQLLEK 1403
Query: 968 QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027
K EI++L+ +++ QE+ +V + ++I+ EN Q
Sbjct: 1404 VKAHEIAWLHGTIQT-HQERPRV-----QNQVILE----ENTTLLGFQDKHFQHQATIAE 1453
Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRA- 1086
+ + ++ + E I+V+ K + ++ GE+ ++ + ++ L E +
Sbjct: 1454 LELEKTKLQELTRKLKERVTILVKQK---DVLSHGEKEEELKAMMHDLQITCSEMQQKVE 1510
Query: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQ-------------VRE 1133
E++KLQ+E ++L++E L + + L + + + V++
Sbjct: 1511 LLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQK 1570
Query: 1134 YMENEKDKALCSLK----------EELIFAQEEKIKELQKIHQ--LELQTMKTQETGDEG 1181
+EN K K + LK EL + ++LQ+++Q E+ K +E G+
Sbjct: 1571 MVENLK-KQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241
K E C TL S L E +K + + +EN ++ ++E +
Sbjct: 1630 LEEREQEKFNLKEELERCKVQSSTLVSSL-EAELSEVKIQTHIVQQEN---HLLKDELEK 1685
Query: 1242 LQDYRY--EVQDFQENMHTLLNKVTEEYN-KLLVLQTRLSKIWGQQTDGM-KLEFGEENL 1297
++ ++ DFQ+ + ++L+ YN KLL + LS+ D + K E +
Sbjct: 1686 MKQLHRCPDLSDFQQKISSVLS-----YNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI 1740
Query: 1298 PKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKET 1357
+ E S Q +L KS+L + Q+ + LE+ VQ + +S ++ L+ T
Sbjct: 1741 ATMKQEQKSWEHQSASL-------KSQLVASQE-KVQNLEDTVQNVNLQMSRMKSDLRVT 1792
Query: 1358 EQNYEA---EIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTI 1414
+Q EA E+ L K+LQ + P + + + + +D +
Sbjct: 1793 QQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSW-------DKLDHLM 1845
Query: 1415 EFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELS---RISGGKENT 1471
+ +E + +++ E + ++ Q L+ ++ ++
Sbjct: 1846 NEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEK 1905
Query: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEI--L 1529
S K+ Q+EQ N K+SQ Q ET+ ++ E K +L E E+ L
Sbjct: 1906 LSLKRECDQFQKEQSPANR-KVSQMNSLEQELETIHLE-NEGLKKKQVKLDEQLMEMQHL 1963
Query: 1530 LSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLED 1589
S + P P + D ++ + +V + ++ + A R +E+LE+
Sbjct: 1964 RSTATPSPSPHAWDL------QLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELEN 2017
Query: 1590 MRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLV 1649
E +Q ++ + + ++ + + LQE++ +L QL + + D
Sbjct: 2018 RTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKAD----- 2072
Query: 1650 SERERVLLEELEALKQLSLAGREKLCCELRN 1680
+ + + +E + LK L + + + E +N
Sbjct: 2073 AMVKDLYVENAQLLKALEVTEQRQKTAEKKN 2103
Score = 103 bits (257), Expect = 3e-21
Identities = 246/1240 (19%), Positives = 509/1240 (41%), Gaps = 178/1240 (14%)
Query: 3 DEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQC 62
D+ERQ+ + A + +D + + R S K A L++ QS C
Sbjct: 977 DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGC 1036
Query: 63 NEM---------YINSSQRVESTVIPESTIMRTLHSGEITSHEQGF--SVELESEISTTA 111
+ ++ Q+ E + ++ +L +HEQ +V++ +EIS
Sbjct: 1037 QVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQR----AHEQAVKENVKMATEISRLQ 1092
Query: 112 DDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI 171
G +P E FG +E Q + T + E ++H +
Sbjct: 1093 QRLQKLEPGLVMSSCLDEPAT----EFFGNTAEQTEPFLQQNRTK----QVEGVTRRHVL 1144
Query: 172 EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLEL 231
+L E +E+R G+ G +Q E I++ + + + +ET E EL
Sbjct: 1145 SDL--EDDEVR-DLGSTGTSSVQRQEVKIEESEASVEGFSE-----LENSEETRTESWEL 1196
Query: 232 TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKK 291
Q +LQ Q L A + D+ K+++ + LE Y+
Sbjct: 1197 KNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKL----KMLERIPEASPKYKLLY 1252
Query: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKE------EIQEKETIIEELNTKIIEEEKKT 345
ED + + LQE++++ E D+ +EN NKE +Q++ +EE+ + EK
Sbjct: 1253 EDVSRENDCLQEELRMMETRYDEALEN-NKELTAEVFRLQDELKKMEEVTETFLSLEKSY 1311
Query: 346 LELKDKLTTADKL-------LGELQEQIVQK------NQEIKNMKLELTNSKQKERQSSE 392
E+K + + L + +LQE +VQ+ ++N+++E + + Q+ E
Sbjct: 1312 DEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLE 1371
Query: 393 E----IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRA-ELDEMYGQQIVQ 447
E ++ + +EE ++ N Q +E TQ LE+++A E+ ++G +Q
Sbjct: 1372 ECVPRVRSVHHVIEECKQEN-----------QYLEGNTQL-LEKVKAHEIAWLHGT--IQ 1417
Query: 448 MKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
QE R + E T G + + + I +++L + EL KL++ +
Sbjct: 1418 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIA----ELELEKTKLQELTRKLKERVT 1473
Query: 508 ----QKEKL-----KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558
QK+ L +EEL ++ + +++ VE L + E++Q+ + + + L
Sbjct: 1474 ILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL 1533
Query: 559 NE----AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYK-------IKLEMLEKEK 607
NE ++ L T+ + E+ +E+ K+ + V N K IK + L+ E
Sbjct: 1534 NEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLEN 1593
Query: 608 NAVLDRMAESQEA--ELERLRTQLLFS------------HEEELSKLKEDLEIEHRINIE 653
+ + +++QE EL + T++L E+E LKE+LE
Sbjct: 1594 TELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELE-------- 1645
Query: 654 KLKDNLGIHYKQQIDGLQNEMSQ-KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS 712
+ + L+ E+S+ KI+T +++N + K E+ K+K L + S
Sbjct: 1646 ----RCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD-----ELEKMKQLHRCPDLS 1696
Query: 713 KSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQ---MKEKENDLQEK 769
++ + L ++L+++E L V +L K+ LLE + MK+++ + +
Sbjct: 1697 DFQQKISSV--LSYNEKLLKEKEALSEELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQ 1753
Query: 770 FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEEN 829
A L+++ +++ + LED + + + L + KS ++ + +E
Sbjct: 1754 SASLKSQLVASQEKVQNLEDTV----------QNVNLQMSRMKS-------DLRVTQQEK 1796
Query: 830 EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEY 889
E LKQ+ + L+++++ E + Q++ K+ D L + + + +
Sbjct: 1797 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKL-DHLMNEEQQLLWQE 1855
Query: 890 KSKLKAL--NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEV 947
+L+ + N + L +++S++ + + + + M E++ L + +
Sbjct: 1856 NERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNP-TEQEKLSLKRECDQ 1914
Query: 948 TKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN--- 1004
++E+ ++++S ++ L+Q+ I NE +K + + ++ + + L +
Sbjct: 1915 FQKEQSPANRKVSQMN-SLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSP 1973
Query: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064
A ++Q Q ++ + + ++N+ EE +E++ S N G
Sbjct: 1974 HAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEE----LENRTSETNTPQG-- 2027
Query: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124
QEQL+ +V +E + Q KL+ +L+ + N L+ Q+ ++V
Sbjct: 2028 -NQEQLV-----TVMEERMIEVEQ-----KLKLVKRLLQEKVNQLKEQLCKNTKADAMVK 2076
Query: 1125 STHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI 1164
+V+ + E + E+ + EEKI L I
Sbjct: 2077 DLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNI 2116
Score = 83.6 bits (205), Expect = 4e-15
Identities = 330/1692 (19%), Positives = 684/1692 (40%), Gaps = 233/1692 (13%)
Query: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR--ELEQALLVSADTFQKVEDRKHF 2176
+E TD C +LS E++ +Q+ + + L RV + ++AL++ + + + +HF
Sbjct: 31 EELTDLCH--MLSLEEVAPVLQQTLLQ-DNLLGRVHFDQFKEALILILS--RTLSNEEHF 85
Query: 2177 GAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE--ELENKNEEVQQLHMQL- 2233
+P+ SLE Q + R + + +E +E+F E +E +EE + H+
Sbjct: 86 ----QEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAG 141
Query: 2234 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE 2293
+ + T R +E E E +L + + L S + S+ Q + K ++ ++ +
Sbjct: 142 DCSEHWKTQRSEEYEAEGQLRFWNPDDL----NASQSGSSPPQDWIEEKLQEVCEDLGIT 197
Query: 2294 ID-QLNEQ--VTKLQQQLKITTDNKVIEEK-NELIRDLETQIE----CLMSDQECVKRNR 2345
D LN + V+ +Q D +++EE + L D +E L + + + +
Sbjct: 198 RDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSA 257
Query: 2346 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2405
QL + Q G++T+ ++ S + LD + ++E+ ++T
Sbjct: 258 STPYRQLKRHLS--MQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGH-ASVERILDTW 314
Query: 2406 NEE-MTFMKNVLKETNFKMN---QLTQELFSLKRERESVEKIQSIPENSVNVA------- 2454
EE + + +LK +F ++ LT+ +L+ E + +NS++ A
Sbjct: 315 QEEGIENSQEILKALDFSLDGNINLTELTLALENE-------LLVTKNSIHQAALASFKA 367
Query: 2455 --------IDHLSKDKPELEVVLTE-DALKSL---ENQTYFKSFEENGKGSIINLETRLL 2502
+D + ++K +L L + + LKSL E + + E + ++ L+
Sbjct: 368 EIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDE--- 424
Query: 2503 QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE 2562
+ + ++A EL + +QI + + E E +K + + +++A +L +LE
Sbjct: 425 EYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLE 484
Query: 2563 -AVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTS 2621
+ E A+ + + ++++ +R N++N+ + +L + L+ L E
Sbjct: 485 NELLENAEKLAEYENLTNKLQR-NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQ 543
Query: 2622 LILEKEQVEIAEKNVLE------------KEKKLLELQKLLEGNEKKQREKEKKRSPQDV 2669
+ ++QV+ + + E K E++ G E + ++ +P ++
Sbjct: 544 CRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNM 603
Query: 2670 EVLKTTTELFHSNEESGFFNELEALRAESVAT----KAELASYKEKAEKLQEELLVKETN 2725
+ EL + ++ LR E + +L +K QE + + N
Sbjct: 604 SI---EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
Query: 2726 MT-SLQKDLSQVRDHLAEAKEKLSILEK---EDETEVQESKKACM--FEPLPIKLSKSIA 2779
T +L+K +S +++ +AE + + ++L++ E +E KK E L + +
Sbjct: 661 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
Query: 2780 SQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEI 2839
Q + LK + + G LQS +EE ++Q ++++ H ++
Sbjct: 721 LQHEMELKARLTQAQASFEREREG----LQSSAWTEEKVRGLTQ------ELEQFHQEQL 770
Query: 2840 LDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTRE 2899
+ +H E E L++E Q +E G K +C ++ S I SD + E
Sbjct: 771 TSLVEKHTLEKEELRKELLEKHQRELQE-GREKMETEC--NRRTSQIEAQFQSDCQKVTE 827
Query: 2900 ICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLS 2959
C S S G+ + D+ + R E+S+ F K + E +
Sbjct: 828 RCESALQSLEGR----YRQELKDLQEQQREEKSQW---EFEKD------ELTQECAEAQE 874
Query: 2960 LTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE-VYDSSQSHES 3018
L + + S+ E + E K Y ++S+ ++ + QL ++ E + + S++ +S
Sbjct: 875 LLKETLKREKTTSLVLTQEREMLE-KTYKEHLNSM--VVERQQLLQDLEDLRNVSETQQS 931
Query: 3019 -FSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQA 3077
SD EL + ++ E VL A +E A + + L + +++ +
Sbjct: 932 LLSDQILELKSSHKRELREREEVLCQAGASEQLA---SQRLERLEMEHDQERQEMMSKLL 988
Query: 3078 AMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQ 3137
AME + KA + E + +++ + +K Q++ P +L+ Q + +E
Sbjct: 989 AMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSP-LSMLQSGCQVIGEEEVEGD 1047
Query: 3138 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3197
LS ++ + +L E+ + + + + +++ T + + L++LE L +
Sbjct: 1048 GALSLLQ-QGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEP-GLVMS 1105
Query: 3198 DKTDE--VHLLNDTLAS-----EQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLE 3250
DE +T +Q ++++++ + + + +E+ DL +
Sbjct: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVL-----SDLEDDEVRDLGSTGT 1160
Query: 3251 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIR 3310
S QR Q+ + ES+ +E L +++ + + L+ Q+ E++ +
Sbjct: 1161 SSVQR----------QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMM- 1209
Query: 3311 EMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEE--KHSRIVELLNETEK 3368
+ + DR E L L +LK+ K LE + S +LL E
Sbjct: 1210 -LCADCDRASEKKQDL------------LFDVSVLKKKLKMLERIPEASPKYKLLYEDVS 1256
Query: 3369 YKLDSLQTRQQMEKDRQ----VHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQ 3424
+ D LQ +M + R + K L E + KKM E+ L++ +E +
Sbjct: 1257 RENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKI 1316
Query: 3425 QVYKLDLEGQRLQGIMQEFQKQELER------EEKRESRRI----LYQNLNEPTTWSLTS 3474
+ +L++ RLQG +++ Q+ ++R E E+ I LN+ +
Sbjct: 1317 ENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPR 1376
Query: 3475 DRTRNWVLQQ-KIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKA 3533
R+ + V+++ K E + E N L ++ HE+ + +Q + +V Q
Sbjct: 1377 VRSVHHVIEECKQENQYLEGNTQLLEKVKA------HEIAWLHGTIQTHQERPRVQNQVI 1430
Query: 3534 SERLQFETADDEDFIWVQENIDEIILQ---LQKLTGQQGEEPSLV---SPSTSCGSLTER 3587
E + Q I E+ L+ LQ+LT + E +++ S G E
Sbjct: 1431 LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEE 1490
Query: 3588 L-------------LRQNAELTGHISQ-LTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNS 3633
L ++Q EL + S+ L +E + LRN + L E+ D+
Sbjct: 1491 LKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE-----------DSI 1539
Query: 3634 SRFSLNGGANIEAIIASEKEVWNR------EKLTLQKSLKRAEAEVYKLK-----AELRN 3682
S L + S++E+W + E +QK ++ + ++ +LK +L N
Sbjct: 1540 SNLKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLEN 1593
Query: 3683 DSLLQTLSPDSE 3694
L Q S + E
Sbjct: 1594 TELSQKNSQNQE 1605
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 157 bits (396), Expect = 3e-37
Identities = 224/1105 (20%), Positives = 486/1105 (43%), Gaps = 167/1105 (15%)
Query: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
++ E EL + ++ EL+E+ + QL E + ++++ T+L A ++
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHS-----QLTEEKNLLQEQLQAETELYAEAEE 908
Query: 217 ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQ 276
R + L + Q+L+ +++A A+ + QQ+L ++Q
Sbjct: 909 MR----------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 277 LEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE------------------------MEQ 312
LEE++ + Q +K +I L+++I V + E+
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 313 DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK--------------DKLTTADKL 358
++K +N K + + E++I EL ++ +EEK EL+ +++
Sbjct: 1019 EEKAKNLTKLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 359 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418
+ EL+ Q+ +K +E++ L + ++ + ++I++L G + +LQ+ + + +
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE-DLDSERAARNK 1136
Query: 419 VQRMEQETQRKLEQLRAELDEMYG-------------QQIVQMKQEL---IRQHMAQMEE 462
++ +++ +LE L+ EL++ Q++ +K+ L R H AQ++E
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 463 MKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522
M+ +H +E +T +Q K +++ L+ N+ LG +E
Sbjct: 1197 MRQKHAQAVE-------ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 523 KCALQRQLEDLVEELSFSREQIQRARQTIAEQESK-----------LNEAH-KSLSTVED 570
+++LE V+EL +RAR + ++ K LNEA K++ +D
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE--LER---- 624
+ A + S + +EL + + N KL LE+E+N++ D++ E EA+ LER
Sbjct: 1310 V-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 625 LRTQLLFSHE--EELSKLKEDLEIEHRINIEKLKDNLGIHYKQ------QIDGLQNEMSQ 676
L QL S + ++ + E LE E + +K +NL Y++ +++ +N + Q
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALE-EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 677 KIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKS-------EEMTLQINELQKEI 728
+++ + + DN Q QL+ + K + Q L K+ E + +KE
Sbjct: 1428 ELDDLVVDLDN----QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKE---KENDLQEKFAQLEAENSILK---D 782
+ L + LE + +EL+ ++L+ +M++ ++D+ + +LE L+ +
Sbjct: 1484 KALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 783 EKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED----LKQQCIQ 838
E KT + L+ +++ +L + ++ +E++++ E+NE+ L++Q +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRL--EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 839 LNEEIE---KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895
E+E KQR + A+K E + ++L+ + +K +++ KQ + ++++K
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE----AIKQLRKLQAQMKD 1656
Query: 896 LNEELHLQRINPTTV-------KMKSSVFDEDKTFVAETLEMGEVVEK----DTTELMEK 944
EL R + + + K+ + D + E L E K + EL E+
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 945 L-------EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997
L + EK L R++ L E+L+++ G + +++ V+ Q+ EQ+S
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-----N 1771
Query: 998 EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057
E+ + A+ +S Q+ + + EG+V KS + + +E K++
Sbjct: 1772 ELATERSTAQKNESARQQLER-QNKELRSKLHEMEGAV----KSKFKSTIAALEAKIAQL 1826
Query: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117
V +E++++Q L K+ Q + K+ ++ ++E+ + R++ ++
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE-QAEKGNARVKQLKRQ 1885
Query: 1118 ICLSLVYSTHVDQVREYMENEKDKA 1142
+ + S ++ R ++ E D+A
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEA 1910
Score = 154 bits (388), Expect = 2e-36
Identities = 232/1212 (19%), Positives = 531/1212 (43%), Gaps = 166/1212 (13%)
Query: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284
++ L++T Q +++Q + +LQ ++ + + +L + +Q+ QL E+ +LL
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN----ELKELEQK----HSQLTEEKNLL 892
Query: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
++ LQ + ++Y ++ +V + K+ QE E I+ E+ ++ EEE +
Sbjct: 893 QEQ-------------LQAETELYAEAEEMRVRLAAKK--QELEEILHEMEARLEEEEDR 937
Query: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
+L+ + + + +L+EQ+ ++ + ++LE ++ K ++ +EI + +L
Sbjct: 938 GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997
Query: 405 QKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEE 462
K + +D+ + E+E + L +L+ + + M + V++K+E + ++E+
Sbjct: 998 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--EKSRQELEK 1055
Query: 463 MKTRHKGEMENALRSYSNITVNEDQIKL--------MNVAINELNIKLQDTNSQKEKLKE 514
+K + +G+ + +++ ++K+ + A+ L+ ++ N+ +K++E
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1115
Query: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
L+ + DL E+L R AR +Q+ L E ++L T + +
Sbjct: 1116 -----------LEGHISDLQEDLDSER----AARNKAEKQKRDLGEELEALKTELE---D 1157
Query: 575 IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHE 634
+ ++ +++EL K E EVT K LD S EA+++ +R + H
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLK-----------KALDEETRSHEAQVQEMRQK----HA 1202
Query: 635 EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694
+ + +L E LE ++ K NL + KQ ++ +++ ++ + K + K+ +
Sbjct: 1203 QAVEELTEQLE-----QFKRAKANLDKN-KQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 695 LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE----ILRQEEKEKGTLEQEV----Q 746
L ++ +L+ +++ E+ ++++LQ E+E +L + E + L ++V
Sbjct: 1257 LEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
+LQ ELL+++ ++K N + K QLE E + L+D+ L++ ++ + + + +
Sbjct: 1316 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNI 1371
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866
SK K + +E L E +K F+ + L +
Sbjct: 1372 QLSDSKKKLQDFASTVEALEE-------------------------GKKRFQKEIENLTQ 1406
Query: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
+Y D LE +KN+ + E L L +L QR + ++ K FD+ +AE
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLDNQRQLVSNLEKKQRKFDQ---LLAE 1459
Query: 927 TLEMGE--VVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984
+ E+D E + + TK L L++ L + E ++ L E++ L
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETK--ALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 985 QEKEQVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGV---------VTMTSRGAEG 1033
K+ V ELE RA ++ TQ+ L D + + + + +G
Sbjct: 1518 SSKDDVGKNVHELE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 1034 SVSK---VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLIL---DHLPSVTKESSLRAT 1087
+ EE + ++ ++ + +E KQ L L K+ L+A
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 1088 QPSE-NDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
+ ++ K+L L+++ D + ++E R +++T + ++ E D L L
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD--LMQL 1692
Query: 1147 KEELIFAQE-EKIKELQK---IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202
+E+L A+ K +L+K +L DE + L I +L++ + EE
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE---- 1748
Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNK 1262
Q + + A + ++ + ++ + Q + ++ + +H +
Sbjct: 1749 -QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807
Query: 1263 VTEEY-NKLLVLQTRLSKIWGQ-QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
V ++ + + L+ +++++ Q + + + + ++L +++ + I Q+ + +
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867
Query: 1321 HKSKL----SSLQDLEK--TKLEEQVQELESLISSLQQQLKETEQNYEA---EIHCLQKR 1371
+K + + ++ L++ + EE+ Q + + LQ++L E ++ EA E++ L+ +
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Query: 1372 LQAVSESTVPPS 1383
L+ +E++ PS
Sbjct: 1928 LRRGNETSFVPS 1939
Score = 151 bits (382), Expect = 1e-35
Identities = 236/1099 (21%), Positives = 484/1099 (44%), Gaps = 146/1099 (13%)
Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
RL V+ LL+ + Q E + + EL + RQ++ E + +++ + E++
Sbjct: 836 RLFTKVKPLLQV----TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL 891
Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
+EQL E + YA+ + + R +K + LE+ L RL+E E QQ
Sbjct: 892 LQEQLQAE-------TELYAEAEEMRVRLAAKKQE----LEEILHEMEARLEEEEDRGQQ 940
Query: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQE---TEKLMKEKLEVQCQAEKVRDD------- 2018
+Q ER+ +++Q +E+QL +E +KL EK+ + + +K+ D+
Sbjct: 941 LQAERKKMAQQML-------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993
Query: 2019 ---LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075
L K+ K LE + + + E E+EK L L+ +++++ +LE K
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLK-------- 1044
Query: 2076 REHERDVFQQEIQKLEQQLK--VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
+ + +QE++KL+++L+ + I++ Q ++ +L L +K + EL +
Sbjct: 1045 ---KEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEE---ELQAALA 1097
Query: 2134 QLQRDIQERN---EEIEKLEFRVRELEQALLVSADTFQKVEDRK-----HFGAVEAKPEL 2185
+L +I ++N ++I +LE + +L++ L K E +K A++ + E
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 2186 SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ 2245
+L+ +++ ++E+E+T L++ L++ E + +E++Q H Q + L
Sbjct: 1158 TLD-STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-------AVEELT 1209
Query: 2246 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2305
E ++ K K +++K +++ +A + VL Q QE E + +L QV +LQ
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLEAQVQELQ 1265
Query: 2306 QQLKITTDNKVIEEKNELIRDLETQIEC---LMSDQECVKRNREEEIEQLNEVI---EKL 2359
K + + E N+ + L+ ++E ++++ E +++ L+ + ++L
Sbjct: 1266 S--KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET 2419
QE S L EE +SL+ QLD + K LE+ + T N +++ K L++
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383
Query: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLEN 2479
+ L + KR ++ +E + E A D L K K L+ L +D + L+N
Sbjct: 1384 ASTVEALEE---GKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQEL-DDLVVDLDN 1438
Query: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
Q S E + +LL E +S+K D +++ + E + K
Sbjct: 1439 QRQLVSNLEKKQRKF----DQLLAEEKNISSK----------YADERDRAEAEAREKETK 1484
Query: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE----- 2594
++L + +EE AL ++ +LE + K ++ S + N+ L + +
Sbjct: 1485 ALSLARALEE----ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 2595 -DELGSDISALTLRISELESQVVEMHTSLILEKEQVE-IAEKNVLEKEKKLLELQKLLE- 2651
+E+ + + L + E + + ++ K Q E + + E+K +LQ+ L
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 2652 -----GNEKKQR---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKA 2703
+E+KQR KK+ D++ L+ + E +L L+A+ +
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQMKDFQR 1659
Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK--EKLSILEKEDETEVQES 2761
EL + +++ E SL+ DL Q+++ LA A+ K + LEKE+
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE------- 1712
Query: 2762 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS-EEVTEI 2820
L++ +AS G + + ++ ++ + A ++ L+ E + E +++
Sbjct: 1713 ------------LAEELASSLSG--RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880
+ + T++ E++ A E ++ S + L+R++ L E G +K+ + +
Sbjct: 1759 VRKATQQAEQLSNELATE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 2881 KEGSSIPELAHSDAYQTRE 2899
+ I +L + RE
Sbjct: 1818 ALEAKIAQLEEQVEQEARE 1836
Score = 144 bits (362), Expect = 2e-33
Identities = 234/1125 (20%), Positives = 480/1125 (42%), Gaps = 130/1125 (11%)
Query: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLR---QAHMRQMERQREDQEQLQEEIK---- 1631
Q+ EE+++ EL + + Q+A L+ Q H + E + QEQLQ E +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 1632 --RLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689
+ +LA + + E ++ E E L EE + +QL A R+K+ ++ +
Sbjct: 906 AEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQ-AERKKMAQQMLDL-------- 955
Query: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETI 1749
E Q E EE ++ +L++ + + L +E + NN+L K +EE I
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK-------ERKLLEERI 1008
Query: 1750 GRHVLGILDRSSKSQSSASLIWR-----SEAEASVKSCVHEEHTRVTDESIPSY---SGS 1801
+ + K+++ L + SE E +K EE +R E + S
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK---EEKSRQELEKLKRKLEGDAS 1065
Query: 1802 DMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPE--NEELMLNISSRLQAAVEKLLE 1859
D ++ +++ E +L+++ A +D E + L L+ + L E
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 1860 AISETSSQLEHAKVTQTELMRESFRQKQEATESLKC---QEELRER-----------LHE 1905
+ + A+ + +L E K E ++L Q+ELR + L E
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 1906 ESRAREQLAVEL-SKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964
E+R+ E E+ K ++ ++ F+R LE+E + L+ L
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC------QAEKVRDD 2018
+Q+++ +++ L Q + ++++ E+ + +K+ K + EV+ +AE
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 2019 LQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQALEKQL----------EKM 2065
L K V +L +++ E ++K +T+L L ++ +L+ QL E+
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125
L+ Q D + + F ++ LE+ K RFQ E+ T++ E+ A +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 2126 SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL 2185
+ L + L D+ + + + LE + R+ +Q L + K D + EA+ +
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 2186 SLEVQL-QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2244
+ + L +A +A++ KE E+ + L+ E+L + ++V + +LE K+ T++
Sbjct: 1483 TKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 2245 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2304
+E++ + + +D+++ A +++ + L G+F + +Q ++ +Q E+ +L
Sbjct: 1542 EEMKTQLEELEDELQ----ATEDAKLRLEVNMQALKGQFERDLQARD---EQNEEKRRQL 1594
Query: 2305 QQQLKITTDNKVIEEKNELI-----RDLETQIECLMSDQECVKRNREEEIEQLNEV---I 2356
Q+QL E K + + LE ++ L + + REE I+QL ++ +
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 2357 EKLQQELAN----------IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETAN 2406
+ Q+EL + ++ A SL EAD ++ Q D+ AE+ +Q +
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSL--EADLMQLQEDLAAAER--ARKQADLEK 1710
Query: 2407 EEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELE 2466
EE+ L + N L E L+ +E+ + ++ D + K + E
Sbjct: 1711 EELA---EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 2467 VVLTEDALK---SLENQTYFKSFEENGKGSIINLETRLLQLE--------STVSAKDLEL 2515
+ E A + + +N++ + E K L ++L ++E ST++A + ++
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNK----ELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 2516 TQCYKQIKDMQEQGQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQDN 2574
Q +Q++ + Q T+ L++K L++I ++ + + Q + +A + A+ Q
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 2575 QTISSEPERTNIQNLN----QLREDELGSDISALTLRISELESQV 2615
+ + E + N N Q DE A+ ++ L+S++
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 143 bits (360), Expect = 4e-33
Identities = 248/1144 (21%), Positives = 503/1144 (43%), Gaps = 154/1144 (13%)
Query: 2394 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNV 2453
E A E +++ E +N LKE K +QLT+E L+ + ++ ++ + E + V
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE-MRV 911
Query: 2454 AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG---SIINLETRLLQLESTVSA 2510
L+ K ELE +L E + E + + + K +++LE +L + E+
Sbjct: 912 ---RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 2511 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA-VQEYAK 2569
LE +IK ++++ + K+ +K++EE+++ + + E + K
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 2570 FCQDNQTISSE------PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI 2623
++++ SE E + Q L +L+ +L D S +I++L++Q+ E+ L
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKR-KLEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 2624 LEKEQV---------EIAEKN-----VLEKEKKLLELQKLLEGNE--KKQREKEKKRSPQ 2667
++E++ EIA+KN + E E + +LQ+ L+ + + EK+K+ +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 2668 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2727
++E LKT ELE +S AT+ EL + +E+ + ++ L +ET
Sbjct: 1147 ELEALKT---------------ELEDT-LDSTATQQELRAKREQEVTVLKKALDEETR-- 1188
Query: 2728 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA-CMFEPLPIKLSKSIASQTDGTL 2786
S + + ++R A+A E+L+ ++++ K+A + L K A
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241
Query: 2787 KISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEKIEKMQ---ELHAAEILDM 2842
+ + Q + K Q+ LQS+CS E ++ +K+ K+Q E + +
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQNEVESVTGMLNEA 1299
Query: 2843 ESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRS--KEGSSIPELAHSDAYQT 2897
E + I + +L + +LL+EE V LR +E +S+ + +
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 2898 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR------AVH 2951
+ + S + I L+ S+ E E F K+I+ L + A +
Sbjct: 1360 QNLERHISTLN----IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 2952 NEGMQVLSLTESPYSD---GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQR--- 3005
++ + + + D D+ Q VS ++RK + ++ K++ +K +R
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-FDQLLAEEKNISSKYADERDRA 1474
Query: 3006 EAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL----- 3060
EAE + S + E L A ++ LE + +L A +L + + D VG
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDLVS--SKDDVGKNVHEL 1530
Query: 3061 ---LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI--QALHAQMNGRKITLKREQESE 3115
LE +++E + + + LQ + L E+ QAL Q R + + EQ E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE-RDLQARDEQNEE 1589
Query: 3116 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3175
K +Q Q Q+ E + EL + +Q + +L+ +L +L+
Sbjct: 1590 KR---------RQLQRQLHEYETELEDER-------KQRALAAAAKKKLEGDLKDLELQA 1633
Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
++ +K + + +K+L + ++KD E+ + + SR+ +A KE K +S
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELE--------DARASRDEIFATAKENEKKAKSL 1685
Query: 3236 ERDKEEL-EDLKFSLESQKQRNLQLNLLLEQQ------KQLLNESQQKIESQRMLYDAQL 3288
E D +L EDL + ++KQ +L+ L E+ + L + ++++E++ + +L
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 3289 SEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL 3348
EEQG +E+ R+R+ + + +L +L + T Q +E ++L
Sbjct: 1746 EEEQGN-------MEAMSDRVRKATQQAE---QLSNELATERSTAQK-----NESARQQL 1790
Query: 3349 QKQLEEKHSRIVELLNETE---KYKLDSLQTR-QQMEKDRQVHRKTLQTEQEANTEGQKK 3404
++Q +E S++ E+ + K + +L+ + Q+E+ + + Q ++ + KK
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 3405 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
+ E+ +VED ++ E+ ++Q K R++ + ++ ++ E E + +RR L + L
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Query: 3465 NEPT 3468
+E T
Sbjct: 1908 DEAT 1911
Score = 133 bits (334), Expect = 4e-30
Identities = 280/1347 (20%), Positives = 551/1347 (40%), Gaps = 217/1347 (16%)
Query: 414 FETDIVQRMEQETQRKLEQLRAELDEMYG------------QQIVQMKQELIRQHMAQME 461
F T ++ +E+E K+ + M QQ+ MK +I+++ A
Sbjct: 770 FRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMK--VIQRNCAAYL 827
Query: 462 EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILE 521
+++ + ++ +T E++++ + + + Q ++ ++L+++ + E
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887
Query: 522 EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED----LKAEIVS 577
EK LQ QL+ E + + E R E E L+E L ED L+AE
Sbjct: 888 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947
Query: 578 ASESRKELELK-HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636
++ +LE + E E K++LE + + EA++++L ++L ++
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKV-------------TAEAKIKKLEDEILVMDDQN 994
Query: 637 LSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696
KE +E RI+ L NL +++ L ++ K E+M E + + K+ +
Sbjct: 995 NKLSKERKLLEERIS--DLTTNLA-EEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSR 1050
Query: 697 LEISKLKDLQQSLVNSKSEEMT-LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELL 755
E+ KLK + + E++ LQ + ++++ ++EE+ + L + E+ K L
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 756 EK--QMKEKENDLQEKF-AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
+K +++ +DLQE ++ A N K ++ E++ + T + LDS ++
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT-----LDSTATQ 1165
Query: 813 SK-DSVWEKEIEIL---IEEN--------EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
+ + E+E+ +L ++E ++++Q+ Q EE+ +Q F A+ N + N
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
Q L++E A L L + KQE+E+K K ++ +++S D +
Sbjct: 1226 KQTLEKENADLAGELRVL--GQAKQEVEHKKK-----------KLEAQVQELQSKCSDGE 1272
Query: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980
+ AE + ++ + + L + + ++L++ ++ LS QL+ L EE
Sbjct: 1273 RA-RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEET 1328
Query: 981 KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1040
+ +K VS + R+LE E S Q+ ++ + E +S +N
Sbjct: 1329 R----QKLNVSTKLRQLE--------EERNSLQDQLDEEME-----AKQNLERHISTLNI 1371
Query: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100
+ K + + + E + G++ Q++ + ++T++ +A + DKL+K N
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKE-----IENLTQQYEEKA---AAYDKLEKTKN 1423
Query: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTH--VDQVREYMENEKDKALCSLKEELIFAQEEKI 1158
L+ E +DL + ++ QR +S + DQ+ +N K A+E++
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 1159 KELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218
K L LE + ++ +E + K+ KA E
Sbjct: 1484 KALSLARALE-EALEAKEELER-------TNKMLKAEME--------------------- 1514
Query: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY----NKLLVLQ 1274
D +S D + +N EL+ + ++ E M T L ++ +E + L L+
Sbjct: 1515 -------DLVSSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 1275 TRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKT 1334
+ + GQ ++ E+N K +H T LED + K +L K
Sbjct: 1567 VNMQALKGQFERDLQAR-DEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKK 1620
Query: 1335 KLEEQVQELE----SLISSLQQQLKETEQNYEAEIHCLQKRLQ------------AVSES 1378
KLE +++LE S I ++ +K+ + +A++ Q+ L+ A
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 1379 TVPPSLPVDSVVITE--SDAQRTMYPGSCVKKNIDGTI--EFSGEFGVKEETNIVKLLEK 1434
SL D + + E + A+R K+ + + SG +++E ++
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494
Q +E+LEEE G E A S + QQ + NE L+
Sbjct: 1740 QLEEELEEE---------------------QGNME--AMSDRVRKATQQAEQLSNE--LA 1774
Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFS 1554
++ Q E+ + + + K L +L E + E+K L E +
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 1555 KDKTFIVRQSIHDEISVSSMDAS-RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHM 1613
++K + S+ D ++++L Q+ED R ++ QY+E + A +
Sbjct: 1835 REKQAATK-------SLKQKDKKLKEILL---QVEDER-KMAEQYKEQAEK----GNARV 1879
Query: 1614 RQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE-NLVSERERVLLEELEALKQLSLAGRE 1672
+Q++RQ E+ E EE +R+N A R + E + +E + E+ ALK G E
Sbjct: 1880 KQLKRQLEEAE---EESQRIN---ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Query: 1673 KLCCELRNSSTQTQNGNENQGEVEEQT 1699
R S + N + E E T
Sbjct: 1934 TSFVPSRRSGGRRVIENADGSEEETDT 1960
Score = 132 bits (331), Expect = 9e-30
Identities = 239/1148 (20%), Positives = 501/1148 (43%), Gaps = 119/1148 (10%)
Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
++RQ+E M+A+ E +L + E+ K + E++ + E+ L ++ L+ ++ +
Sbjct: 847 VTRQEEEMQAK----EDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR----EHERDVFQQEIQKLE 2091
+ E E+ + + L + Q LE+ L +M L+E+ DR + ER Q++ LE
Sbjct: 902 LYAEAEEMR----VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLE 956
Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151
+QL+ + + Q ++E++ K K + E+L+ +Q + +ER + LE
Sbjct: 957 EQLE-----EEEAARQKLQLEKVTAEAKIKKLE-DEILVMDDQNNKLSKER----KLLEE 1006
Query: 2152 RVRELEQALLVSADTFQKVEDRKHFGAVEAKPE---LSLEVQLQAERDAIDRKEKEITNL 2208
R+ +L + + ++ E K+ ++ K E LEV+L+ E + EK L
Sbjct: 1007 RISDL------TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2268
E F E++ + ++ +L MQL +++E L L+ E + ++K I+E
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK----IREL 1116
Query: 2269 DAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLE 2328
+ + Q L + A + ++ + D L E++ L+ +L+ T D+ +++ R+ E
Sbjct: 1117 EGHISDLQEDLDSERAARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 2329 TQIECLMSDQEC---------VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2379
+ D+E +++ + +E+L E +E+ ++ AN+ + N +L +
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK----NKQTLEK 1231
Query: 2380 EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERES 2439
E L +L V+ K +E + + ++ +++ + +L ++ L+ E ES
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291
Query: 2440 VEKIQSIPE-NSVNVAID--HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIIN 2496
V + + E ++ +A D LS + + +L E+ + L T + EE
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ 1351
Query: 2497 LETRL---LQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIV 2547
L+ + LE +S +++L+ K+++D E+G+ + QK+I NL +
Sbjct: 1352 LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK---KRFQKEIENLTQQY 1408
Query: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2607
EEK AA +LE + + D+ + + +R + NL + + +
Sbjct: 1409 EEKAAA----YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR------------K 1452
Query: 2608 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ 2667
+L ++ + + E+++ AE EKE K L L + LE + + E E+
Sbjct: 1453 FDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 2668 DVEVLKTTTELFHSNEESG-FFNELE----ALRAESVATKAELASYKEKAEKLQEELLVK 2722
E+ +L S ++ G +ELE AL + K +L +++ + ++ L
Sbjct: 1510 KAEM----EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 2723 ETNMTSL----QKDLSQVRDHLAEAKEKLSILEKEDETEVQ-ESKKACMFEPLPIKLS-- 2775
E NM +L ++DL + E + +L E ETE++ E K+ + KL
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 2776 -KSIASQTDGTLK--ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQ 2832
K + Q D +K + Q ++ + Q L+ +S + EI + E +K +
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD--EIFATAKENEKKAK 1683
Query: 2833 ELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHS 2892
L A+++ ++ ++ E +++ + + L EE + + L+ ++ +A
Sbjct: 1684 SLE-ADLMQLQ-EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 2893 DAYQTREICSSDSGSD-WGQGIYLTHSQGFDIASE-GRGEESESATDSFPKKIKGLLRAV 2950
+ E + ++ SD + ++A+E +++ESA ++ K L +
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1801
Query: 2951 HNEGMQVLSLTESPYS--DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE 3008
H V S +S + + + +++ E E++A ++ + ++ LQ E E
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 3009 VYDSSQSHESFSDWRGEL-LLALQQVFLEERSVLLAAFRTEL-----TALGTTDAVGL-L 3061
+ Q E + L Q EE S + A R +L A + +A+G +
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921
Query: 3062 NCLEQRIQ 3069
N L+ +++
Sbjct: 1922 NALKSKLR 1929
Score = 131 bits (329), Expect = 1e-29
Identities = 213/1071 (19%), Positives = 450/1071 (42%), Gaps = 162/1071 (15%)
Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
E+E+R ++L+A + K+AQ + + + +QK + + +++ + D +
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
N + +E + +T E + + ES IS E
Sbjct: 993 QNNKLSKERKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE---- 1046
Query: 122 SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
++ + L+ + G + EQ A D + ++ +LA K+ E++ L++
Sbjct: 1047 ---EKSRQELEKLKRKLEGDASDFHEQIA-DLQAQIAELKMQLAKKEEELQAALARLDD- 1101
Query: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
+ L++++E E G I+ L +L R +++ ++ +L E+ + L+ +
Sbjct: 1102 EIAQKNNALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154
Query: 242 F----------QQLQASE-----TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLED 286
Q+L+A L+ + T + Q ++ H Q +EE LE
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 287 YQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----ETIIEELNTKIIEEE 342
+++ K + L+++ ++ + +V K+E++ K E ++EL +K + E
Sbjct: 1215 FKRAKANLDKNKQTLEKENA--DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 343 KKTLELKDK-------LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIK 395
+ EL DK + + +L E + + ++ +++ ++ +L ++++ EE +
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETR 1329
Query: 396 QLMGTVEELQKRNHKDSQFETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Q + +L++ + + + + + ME Q +R + L +L + + K +
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQDF 1383
Query: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNIKLQDTNSQKEKL 512
+ +EE K R + E+EN + Y D++ K N EL+ + D ++Q++ +
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443
Query: 513 KEELGLILEEKCALQRQLEDLV-EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL 571
LE+K QR+ + L+ EE + S + + AE K K+LS L
Sbjct: 1444 SN-----LEKK---QRKFDQLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARAL 1492
Query: 572 KAEIVSASESRKELELKHEAEVTNYKIKLEM--LEKEKNAV------LDRMAESQEAELE 623
+ + LE K E E TN +K EM L K+ V L++ + E ++E
Sbjct: 1493 E----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK----------DNLGIHYKQQIDGLQNE 673
++TQL E+ + ED ++ +N++ LK D ++Q+ +E
Sbjct: 1543 EMKTQL--EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 674 MSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE------EMTLQINELQKE 727
++E + ++ + +L ++ L+ S + + E ++ Q+ + Q+E
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 728 IEILR-----------QEEKEKGTLEQEVQELQ---LKTELLEKQMKEKENDLQEKFAQL 773
+E R + EK+ +LE ++ +LQ E KQ ++ +L E+ A
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 774 EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK 833
+ + L+DEK+ LE + +EE + +E + +
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEE-----------------QGNMEAMSDRVRKAT 1763
Query: 834 QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL 893
QQ QL+ E+ +R+T A+KN E Q+L+ + +++ L + + + ++KS +
Sbjct: 1764 QQAEQLSNELATERST---AQKN-ESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTI 1816
Query: 894 KAL-----------NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942
AL +E ++ ++K K E V + +M E ++ +
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Query: 943 EKLEVTKR---EKLELSQRLSDLSEQLKQKHGEISFLNE----EVKSLKQE 986
+++ KR E E SQR++ +L+++ E + NE EV +LK +
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 122 bits (306), Expect = 7e-27
Identities = 253/1214 (20%), Positives = 509/1214 (41%), Gaps = 161/1214 (13%)
Query: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143
++E+Q E +L+ Q +E++ +E+EQ + L E+ + E L ++ +L + +E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 2144 EEI----EKLEFRVRELEQALLVSADTFQKVE-DRKHFGAVEAKPELSLEVQLQAERDAI 2198
+ ++LE + E+E L D Q+++ +RK A+ L LE QL+ E A
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM----AQQMLDLEEQLEEEEAAR 966
Query: 2199 DRKEKEITNLEEQLEQFREEL---ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2255
+ + E E ++++ +E+ +++N ++ + LE + + TT L E E++ K
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 2256 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2315
K I E + +++ + ++ ++ E + +EQ+ LQ Q
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQ-------- 1077
Query: 2316 VIEEKNELIRDLETQIECL--MSDQECVKRNREEEIEQLNEVIEKLQQELAN---IGQKT 2370
+ E K +L + E L + D+ K N ++I +L I LQ++L + K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 2371 SMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE-EMTFMKNVLKETNFKMNQLTQE 2429
L EE ++LK +L+ + + A +Q++ E E+T +K L E QE
Sbjct: 1138 EKQKRDLGEELEALKTELEDTL-DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 2430 LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEEN 2489
+ ++ ++VE++ E A +L K+K LE +EN
Sbjct: 1197 M--RQKHAQAVEELTEQLEQFKR-AKANLDKNKQTLE--------------------KEN 1233
Query: 2490 GKGSIINLETRLL-QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
+ E R+L Q + V K +L ++++ G+ L K+ LQ VE
Sbjct: 1234 AD---LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 2549 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRI 2608
V+ + EA + K +D ++SS+ +Q+ +L ++E ++ T ++
Sbjct: 1291 S------VTGMLNEAEGKAIKLAKDVASLSSQ-----LQDTQELLQEETRQKLNVST-KL 1338
Query: 2609 SELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE--GNEKKQREKEKKRSP 2666
+LE + + L E E + E+++ +L + +K L+ + + E+ KKR
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398
Query: 2667 QDVEVLKTTTELFHSNEESGFFNELEALRAE----------SVATKAELASYKEKAEKLQ 2716
+++E L E E++ +++LE + + + +L S EK ++
Sbjct: 1399 KEIENLTQQYE-----EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 2717 EELLVKETNMTSLQKDLSQVRDHL-AEAKEK----LSILEKEDETEVQESKKACMFEPLP 2771
++LL +E N++S D RD AEA+EK LS+ +E + + + L
Sbjct: 1454 DQLLAEEKNISSKYAD---ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 2772 IKLSKSIASQTD---GTLKISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEK 2827
++ ++S+ D ++ S + + ++ Q+ L+ E + E ++ + +
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 2828 IEKMQ---ELHAAEILDMESR---------HISETETLKREHYVAVQLLKEECGTLKAV- 2874
K Q +L A + + E R + +E E +++ +A K+ G LK +
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 2875 IQCLRSKEG--SSIPELAHSDAYQT---REICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2929
+Q + +G +I +L A RE+ + + D I+ T + +E +
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD---EIFATAKE-----NEKKA 1682
Query: 2930 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2989
+ E+ + + RA ++ L E S + Q + LE R A
Sbjct: 1683 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA--- 1739
Query: 2990 TISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTEL 3049
Q E E+ + + E+ SD + A QQ E+ S LA R+
Sbjct: 1740 --------------QLEEELEEEQGNMEAMSD---RVRKATQQA--EQLSNELATERS-- 1778
Query: 3050 TALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLK 3109
TA A Q+++ Q E ++ + ++ A + S I AL A++ L+
Sbjct: 1779 TAQKNESA-------RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI----AQLE 1827
Query: 3110 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA 3169
+ E E ++ +++QK ++ E+ +++ + A + +EQ V +LK +L
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 3170 QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA 3229
+ + E + + K +EL+ E + + + + L S+ ++ E + +
Sbjct: 1888 EAEEESQRINANRRKLQRELD----EATESNEAMGREVNALKSKLRRGNETSFVPSRRSG 1943
Query: 3230 KLGRSEERDKEELE 3243
E D E E
Sbjct: 1944 GRRVIENADGSEEE 1957
Score = 117 bits (292), Expect = 3e-25
Identities = 242/1207 (20%), Positives = 495/1207 (41%), Gaps = 201/1207 (16%)
Query: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
+++ L + +EE + KED ++K K+ +Q+ + E+ QK +
Sbjct: 840 KVKPLLQVTRQEEEMQAKED-------ELQKTKER-----QQKAENELKELEQKHSQLTE 887
Query: 684 EKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGT-L 741
EK NL+ +Q Q E+ ++ ++++ L K E + E+ E+E +EE+++G L
Sbjct: 888 EK-NLLQEQLQAETELYAEAEEMRVRLAAKKQE-----LEEILHEMEARLEEEEDRGQQL 941
Query: 742 EQEVQELQLKTELLEKQMKEKE-----------------NDLQEKFAQLEAENSILKDEK 784
+ E +++ + LE+Q++E+E L+++ ++ +N+ L E+
Sbjct: 942 QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844
K LE+ + T EE + K K+K E+E+ +++ E +Q+ +L ++E
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 845 KQRNTFSFAEKNFEVNYQEL--------QEEYACLLKVKDDLEDSKN--KQELEYKSKLK 894
+ F + + EL +E A L ++ D++ N K+ E + +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 895 ALNEELHLQRINPTTVKMKSSVFDED----KTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
L E+L +R + + E+ KT + +TL+ ++ + +++ V K+
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 951 EKLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENV 1009
E ++ ++++QKH + + L E+++ K+ K + + LE EN
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-------KENA 1234
Query: 1010 Q-SCDTQVSSLLDGVVTMTSRGAEGSVSKVNK--SFGEESKIMVEDKV--------SFEN 1058
+ + +V V + E V ++ S GE ++ + DKV S
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 1059 MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRI 1118
M E K +L D + S L+ TQ ++ +++LNV LR Q+E +R
Sbjct: 1295 MLNEAEGKAIKLAKD---VASLSSQLQDTQELLQEETRQKLNV----STKLR-QLEEERN 1346
Query: 1119 CLSLVYSTHVDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176
L DQ+ E ME ++ ++ + +L +L + K+LQ T E
Sbjct: 1347 SLQ-------DQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDF-------ASTVE 1388
Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYIS 1235
+EGK + QK + E T + + A DK E + + +
Sbjct: 1389 ALEEGKK------RFQKEI----------------ENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 1236 ENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEE 1295
+ D + D D Q + + L K ++++LL + +S + + D + E E+
Sbjct: 1427 QELDDLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 1296 -----NLPKEETEFLSIHSQM--------TNLEDIDVNHKSKLSSLQDLEKTK--LEEQV 1340
+L + E L ++ +ED+ + ++ +LEK+K LE Q+
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 1341 QELESLISSLQQQLKETEQ-------NYEAEIHCLQKRLQAVSEST------VPPSLPVD 1387
+E+++ + L+ +L+ TE N +A ++ LQA E + L
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 1388 SVVITESDAQRTMYPGSCVKKNIDG---TIEFSGEFGVKEETNIVKLLE------KQYQE 1438
+ + QR + + KK ++G +E + +K +K L K +Q
Sbjct: 1602 ETELEDERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659
Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGG----KENTASSKQAHAVCQQEQHYFNEMKLS 1494
+LE+ A + A + + + +E+ A++++A E+ E +L+
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE-ELA 1718
Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKEL-GEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553
G + + + L +EL E G +S+ +++ ++ E
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 1554 SKDKTFIVRQ-----------SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ 1602
+ K RQ +H+ + E ++ + +++ ++ +E Q
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 1603 QATELLRQAHMR------QMERQREDQEQLQEE-------IKRLNRQLAQRSSIDNENLV 1649
AT+ L+Q + Q+E +R+ EQ +E+ +K+L RQL + + +++ +
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EEAEEESQRIN 1897
Query: 1650 SERERVLLEELEALKQLSLAGRE--KLCCELRNSSTQTQNGNENQG---EVEEQTFKEKE 1704
+ R ++ E EA + GRE L +LR + + + G +E E+E
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1957
Query: 1705 LDRKPED 1711
D + D
Sbjct: 1958 TDTRDAD 1964
Score = 82.8 bits (203), Expect = 6e-15
Identities = 170/823 (20%), Positives = 351/823 (42%), Gaps = 127/823 (15%)
Query: 2931 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2990
++E+ + ++++ L A E ++L E+ + ED Q +E RK
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-----RKKMAQQ 951
Query: 2991 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL--------LALQQVFLEERSVLL 3042
+ L++ + + + R+ + + E+L L+ ++ LEER L
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 3043 AAFRTE-------LTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSE 3093
E LT L +++ LE R++++ Q + +K D +
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHE-SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 3094 IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3153
I L AQ+ K+ L +++E + + L+ I QK + + +++ ++ ++LQE
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQED 1126
Query: 3154 LSSEKMV-------VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3206
L SE+ +L EL K ELE TL + +EL A R + EV +L
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVL 1179
Query: 3207 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK---FSLESQKQRNLQLNLLL 3263
L E+ +S E Q +++ + K ++ E E+LE K +L+ KQ + N L
Sbjct: 1180 KKAL-DEETRSHEAQ--VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236
Query: 3264 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3323
+ ++L +++Q++E ++ +AQ+ E Q + + E+ R + D+ +L
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSK------CSDGERAR----AELNDKVHKLQ 1286
Query: 3324 AQLQSSDGT---GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3380
+++S G + + ++D+ L QL++ ELL E + KL+ +Q+
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQ----ELLQEETRQKLNVSTKLRQL 1341
Query: 3381 EKDRQVHRKTLQTEQEAN--------------TEGQKKMHE--------------LQSKV 3412
E++R + L E EA ++ +KK+ + Q ++
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401
Query: 3413 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF------QKQELEREEKRESR--RILYQNL 3464
E+L +Q EEK KL+ RLQ + + Q+Q + EK++ + ++L +
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELE----MIRQKLQ 3520
N + ++ DR + E ETK + A+ +E ELE M++ +++
Sbjct: 1462 NISSKYADERDRAE----AEAREKETKALSLARALE---EALEAKEELERTNKMLKAEME 1514
Query: 3521 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ-QGEEPSLVSPST 3579
+ S + + E + + A ++ ++E+ QL++L + Q E + +
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQLEELEDELQATEDAKLRLEV 1567
Query: 3580 SCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3639
+ +L + R +L Q E++ L+ + + E ++ R+ A +++ L
Sbjct: 1568 NMQALKGQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLE 1623
Query: 3640 GGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
G + + ++ + RE+ K L++ +A++ + EL +
Sbjct: 1624 GDLK-DLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELED 1663
Score = 76.3 bits (186), Expect = 6e-13
Identities = 119/577 (20%), Positives = 241/577 (41%), Gaps = 64/577 (11%)
Query: 3161 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK---KS 3217
V + E+ + EL+ T + Q K EL+ + T+E +LL + L +E + ++
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 3218 RELQWALEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3274
E++ L +K +L E EE ED L++++++ Q L LE+Q + ++
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 3275 QKIESQRMLYDAQLS---------EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3325
QK++ +++ +A++ ++Q L + L E RI ++++ L E E
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE--RISDLTTNLAEEEEKAKN 1024
Query: 3326 LQSSDGTGQS---------RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3376
L +S + S L++L+++LE S E + + + +
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 3377 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE---- 3432
+ E++ Q L E KK+ EL+ + DLQ L+ +R K + +
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 3433 GQRLQGIMQEFQ--------KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3484
G+ L+ + E + +QEL R ++ + +L + L+E T + Q
Sbjct: 1145 GEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 3485 KIEGETKESNYAKLIEMN---------GGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3535
+E T++ K + N EL ++ Q Q V K + L + E
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 3536 RLQFETADDEDF-IWVQENIDEIILQLQKLTGQQGE-EPSLVSPSTSCGSLTERL----- 3588
LQ + +D E + + + ++ +++ +TG E E + + SL+ +L
Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322
Query: 3589 -----LRQNAELTGHISQLTEEKNDLRNMV---MKLEEQIRWYRQTGAGRDNSSRFSLNG 3640
RQ ++ + QL EE+N L++ + M+ ++ + + T + + S+ L
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 3641 GANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLK 3677
A+ + K+ + +E L + + A KL+
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Score = 71.6 bits (174), Expect = 1e-11
Identities = 92/466 (19%), Positives = 200/466 (42%), Gaps = 52/466 (11%)
Query: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240
A + L+ + +RL K K LL T E+ +++E + KE+ + +E ++ E
Sbjct: 824 AAYLKLRNWQWWRLFTKVKP----LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 879
Query: 3241 E----LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3296
+ L + K L+ Q Q +L E+ + L +Q++E +A+L EE+ R
Sbjct: 880 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 939
Query: 3297 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL---------LKE 3347
+LQ + ++ ++ L+ E +LQ T +++ +++ L +
Sbjct: 940 QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3407
+K LEE+ S + L E E+ + + + + E L+ E+++ E +K +
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 3408 LQSKVEDLQRQLEEKRQQVYKLDLE----GQRLQGIMQEFQKQELEREEKRESRRILYQN 3463
L+ D Q+ + + Q+ +L ++ + LQ + + ++ + R L +
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119
Query: 3464 LNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ--- 3520
+++ LQ+ ++ E N A+ + + G ELE ++ +L+
Sbjct: 1120 ISD---------------LQEDLDSERAARNKAEKQKRDLG-----EELEALKTELEDTL 1159
Query: 3521 -CVASKLQVLPQKASERLQFETADDEDF----IWVQENIDEIILQLQKLTGQQGEEPSLV 3575
A++ ++ ++ E + A DE+ VQE + +++LT Q +
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ---FK 1216
Query: 3576 SPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3621
+ + L ++NA+L G + L + K ++ + KLE Q++
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262
Score = 70.5 bits (171), Expect = 3e-11
Identities = 90/425 (21%), Positives = 184/425 (43%), Gaps = 61/425 (14%)
Query: 169 HEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ----------QAR 218
HE+E+ R LE T E QL+E E ++ + +L N+Q QAR
Sbjct: 1528 HELEKSKRALE----TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583
Query: 219 REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADL----LQAKQQILTHQ 274
E++E R +L Q + + + + + L + DL LQA I +
Sbjct: 1584 DEQNEEKRR--QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 275 Q---QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331
+ QL + ++D+Q++ ED +++I E +KK ++ + +Q +E +
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARAS----RDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Query: 332 EELNTKI---IEEEKKTLELKDKLTTADKLLGE---LQEQIVQKNQEIKNMKLELTNSKQ 385
+ +E+E+ EL L+ + L E L+ +I Q +E++ + +
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 386 KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQI 445
+ R+++++ +QL + + K+ + Q+ +R+ ++LR++L EM G
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGAVK 1809
Query: 446 VQMKQEL--IRQHMAQMEEMKTRHKGEMENALRSYSN--------ITVNEDQIKLMNVAI 495
+ K + + +AQ+EE + E + A +S + ED+ K+
Sbjct: 1810 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1869
Query: 496 NEL---NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE-------ELSFSREQIQ 545
+ N +++ Q E+ +EE I + LQR+L++ E E++ + +++
Sbjct: 1870 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Query: 546 RARQT 550
R +T
Sbjct: 1930 RGNET 1934
Score = 58.5 bits (140), Expect = 1e-07
Identities = 91/505 (18%), Positives = 214/505 (42%), Gaps = 75/505 (14%)
Query: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63
E++Q+K + A+ + A ++ ++ ++K+ K S + + + + N
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506
Query: 64 EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
+M +E V + + + +H E+ ++ ++E E+ T ++ E+
Sbjct: 1507 KML---KAEMEDLVSSKDDVGKNVH--ELEKSKRALETQME-EMKTQLEELEDELQATED 1560
Query: 124 V-MRTGKPTNLLR---EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI-------E 172
+R L+ E + D +E+ + L E+EL ++ + +
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620
Query: 173 ELNRELEEMRVTYGT------EGLQQLQEFEAAIKQ-----------RDGIITQLTANLQ 215
+L +L+++ + + E ++QL++ +A +K RD I N +
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680
Query: 216 QARREKDETMR--EFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA--DLLQAKQQIL 271
+A+ + + M+ E L E+++K Q ++ + +E L +S A + + + +I
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARK-QADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 272 THQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331
+++LEE+ +E + T Q L E+ ++ N+ Q+ E
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSN-----ELATERSTAQKNESARQQLERQN 1794
Query: 332 EELNTKIIEEEKKTL-ELKDKLTTADKLLGELQEQIVQ--------------KNQEIKNM 376
+EL +K+ E E + K + + + +L+EQ+ Q K++++K +
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 377 KLELTNSKQKERQSSEE-------IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
L++ + ++ Q E+ +KQL +EE ++ E+ + ++ QR+
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--------ESQRINANRRKLQRE 1906
Query: 430 LEQLRAELDEMYGQQIVQMKQELIR 454
L++ E +E G+++ +K +L R
Sbjct: 1907 LDE-ATESNEAMGREVNALKSKLRR 1930
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 157 bits (396), Expect = 3e-37
Identities = 224/1105 (20%), Positives = 486/1105 (43%), Gaps = 167/1105 (15%)
Query: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
++ E EL + ++ EL+E+ + QL E + ++++ T+L A ++
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHS-----QLTEEKNLLQEQLQAETELYAEAEE 915
Query: 217 ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQ 276
R + L + Q+L+ +++A A+ + QQ+L ++Q
Sbjct: 916 MR----------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 277 LEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE------------------------MEQ 312
LEE++ + Q +K +I L+++I V + E+
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 313 DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK--------------DKLTTADKL 358
++K +N K + + E++I EL ++ +EEK EL+ +++
Sbjct: 1026 EEKAKNLTKLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 359 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418
+ EL+ Q+ +K +E++ L + ++ + ++I++L G + +LQ+ + + +
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE-DLDSERAARNK 1143
Query: 419 VQRMEQETQRKLEQLRAELDEMYG-------------QQIVQMKQEL---IRQHMAQMEE 462
++ +++ +LE L+ EL++ Q++ +K+ L R H AQ++E
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 463 MKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522
M+ +H +E +T +Q K +++ L+ N+ LG +E
Sbjct: 1204 MRQKHAQAVE-------ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 523 KCALQRQLEDLVEELSFSREQIQRARQTIAEQESK-----------LNEAH-KSLSTVED 570
+++LE V+EL +RAR + ++ K LNEA K++ +D
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE--LER---- 624
+ A + S + +EL + + N KL LE+E+N++ D++ E EA+ LER
Sbjct: 1317 V-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 625 LRTQLLFSHE--EELSKLKEDLEIEHRINIEKLKDNLGIHYKQ------QIDGLQNEMSQ 676
L QL S + ++ + E LE E + +K +NL Y++ +++ +N + Q
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALE-EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 677 KIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKS-------EEMTLQINELQKEI 728
+++ + + DN Q QL+ + K + Q L K+ E + +KE
Sbjct: 1435 ELDDLVVDLDN----QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKE---KENDLQEKFAQLEAENSILK---D 782
+ L + LE + +EL+ ++L+ +M++ ++D+ + +LE L+ +
Sbjct: 1491 KALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 783 EKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED----LKQQCIQ 838
E KT + L+ +++ +L + ++ +E++++ E+NE+ L++Q +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRL--EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 839 LNEEIE---KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895
E+E KQR + A+K E + ++L+ + +K +++ KQ + ++++K
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE----AIKQLRKLQAQMKD 1663
Query: 896 LNEELHLQRINPTTV-------KMKSSVFDEDKTFVAETLEMGEVVEK----DTTELMEK 944
EL R + + + K+ + D + E L E K + EL E+
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 945 L-------EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997
L + EK L R++ L E+L+++ G + +++ V+ Q+ EQ+S
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-----N 1778
Query: 998 EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057
E+ + A+ +S Q+ + + EG+V KS + + +E K++
Sbjct: 1779 ELATERSTAQKNESARQQLER-QNKELRSKLHEMEGAV----KSKFKSTIAALEAKIAQL 1833
Query: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117
V +E++++Q L K+ Q + K+ ++ ++E+ + R++ ++
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE-QAEKGNARVKQLKRQ 1892
Query: 1118 ICLSLVYSTHVDQVREYMENEKDKA 1142
+ + S ++ R ++ E D+A
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEA 1917
Score = 154 bits (388), Expect = 2e-36
Identities = 232/1212 (19%), Positives = 531/1212 (43%), Gaps = 166/1212 (13%)
Query: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284
++ L++T Q +++Q + +LQ ++ + + +L + +Q+ QL E+ +LL
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN----ELKELEQK----HSQLTEEKNLL 899
Query: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344
++ LQ + ++Y ++ +V + K+ QE E I+ E+ ++ EEE +
Sbjct: 900 QEQ-------------LQAETELYAEAEEMRVRLAAKK--QELEEILHEMEARLEEEEDR 944
Query: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
+L+ + + + +L+EQ+ ++ + ++LE ++ K ++ +EI + +L
Sbjct: 945 GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004
Query: 405 QKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEE 462
K + +D+ + E+E + L +L+ + + M + V++K+E + ++E+
Sbjct: 1005 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--EKSRQELEK 1062
Query: 463 MKTRHKGEMENALRSYSNITVNEDQIKL--------MNVAINELNIKLQDTNSQKEKLKE 514
+K + +G+ + +++ ++K+ + A+ L+ ++ N+ +K++E
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122
Query: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
L+ + DL E+L R AR +Q+ L E ++L T + +
Sbjct: 1123 -----------LEGHISDLQEDLDSER----AARNKAEKQKRDLGEELEALKTELE---D 1164
Query: 575 IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHE 634
+ ++ +++EL K E EVT K LD S EA+++ +R + H
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLK-----------KALDEETRSHEAQVQEMRQK----HA 1209
Query: 635 EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694
+ + +L E LE ++ K NL + KQ ++ +++ ++ + K + K+ +
Sbjct: 1210 QAVEELTEQLE-----QFKRAKANLDKN-KQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 695 LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE----ILRQEEKEKGTLEQEV----Q 746
L ++ +L+ +++ E+ ++++LQ E+E +L + E + L ++V
Sbjct: 1264 LEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
+LQ ELL+++ ++K N + K QLE E + L+D+ L++ ++ + + + +
Sbjct: 1323 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNI 1378
Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866
SK K + +E L E +K F+ + L +
Sbjct: 1379 QLSDSKKKLQDFASTVEALEE-------------------------GKKRFQKEIENLTQ 1413
Query: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
+Y D LE +KN+ + E L L +L QR + ++ K FD+ +AE
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLDNQRQLVSNLEKKQRKFDQ---LLAE 1466
Query: 927 TLEMGE--VVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984
+ E+D E + + TK L L++ L + E ++ L E++ L
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETK--ALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 985 QEKEQVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGV---------VTMTSRGAEG 1033
K+ V ELE RA ++ TQ+ L D + + + + +G
Sbjct: 1525 SSKDDVGKNVHELE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 1034 SVSK---VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLIL---DHLPSVTKESSLRAT 1087
+ EE + ++ ++ + +E KQ L L K+ L+A
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 1088 QPSE-NDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
+ ++ K+L L+++ D + ++E R +++T + ++ E D L L
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD--LMQL 1699
Query: 1147 KEELIFAQE-EKIKELQK---IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202
+E+L A+ K +L+K +L DE + L I +L++ + EE
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE---- 1755
Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNK 1262
Q + + A + ++ + ++ + Q + ++ + +H +
Sbjct: 1756 -QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814
Query: 1263 VTEEY-NKLLVLQTRLSKIWGQ-QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
V ++ + + L+ +++++ Q + + + + ++L +++ + I Q+ + +
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874
Query: 1321 HKSKL----SSLQDLEK--TKLEEQVQELESLISSLQQQLKETEQNYEA---EIHCLQKR 1371
+K + + ++ L++ + EE+ Q + + LQ++L E ++ EA E++ L+ +
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Query: 1372 LQAVSESTVPPS 1383
L+ +E++ PS
Sbjct: 1935 LRRGNETSFVPS 1946
Score = 151 bits (382), Expect = 1e-35
Identities = 236/1099 (21%), Positives = 484/1099 (44%), Gaps = 146/1099 (13%)
Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
RL V+ LL+ + Q E + + EL + RQ++ E + +++ + E++
Sbjct: 843 RLFTKVKPLLQV----TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL 898
Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
+EQL E + YA+ + + R +K + LE+ L RL+E E QQ
Sbjct: 899 LQEQLQAE-------TELYAEAEEMRVRLAAKKQE----LEEILHEMEARLEEEEDRGQQ 947
Query: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQE---TEKLMKEKLEVQCQAEKVRDD------- 2018
+Q ER+ +++Q +E+QL +E +KL EK+ + + +K+ D+
Sbjct: 948 LQAERKKMAQQML-------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000
Query: 2019 ---LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075
L K+ K LE + + + E E+EK L L+ +++++ +LE K
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLK-------- 1051
Query: 2076 REHERDVFQQEIQKLEQQLK--VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
+ + +QE++KL+++L+ + I++ Q ++ +L L +K + EL +
Sbjct: 1052 ---KEEKSRQELEKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEE---ELQAALA 1104
Query: 2134 QLQRDIQERN---EEIEKLEFRVRELEQALLVSADTFQKVEDRK-----HFGAVEAKPEL 2185
+L +I ++N ++I +LE + +L++ L K E +K A++ + E
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 2186 SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ 2245
+L+ +++ ++E+E+T L++ L++ E + +E++Q H Q + L
Sbjct: 1165 TLD-STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ-------AVEELT 1216
Query: 2246 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2305
E ++ K K +++K +++ +A + VL Q QE E + +L QV +LQ
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLEAQVQELQ 1272
Query: 2306 QQLKITTDNKVIEEKNELIRDLETQIEC---LMSDQECVKRNREEEIEQLNEVI---EKL 2359
K + + E N+ + L+ ++E ++++ E +++ L+ + ++L
Sbjct: 1273 S--KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET 2419
QE S L EE +SL+ QLD + K LE+ + T N +++ K L++
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390
Query: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLEN 2479
+ L + KR ++ +E + E A D L K K L+ L +D + L+N
Sbjct: 1391 ASTVEALEE---GKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQEL-DDLVVDLDN 1445
Query: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
Q S E + +LL E +S+K D +++ + E + K
Sbjct: 1446 QRQLVSNLEKKQRKF----DQLLAEEKNISSK----------YADERDRAEAEAREKETK 1491
Query: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE----- 2594
++L + +EE AL ++ +LE + K ++ S + N+ L + +
Sbjct: 1492 ALSLARALEE----ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 2595 -DELGSDISALTLRISELESQVVEMHTSLILEKEQVE-IAEKNVLEKEKKLLELQKLLE- 2651
+E+ + + L + E + + ++ K Q E + + E+K +LQ+ L
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 2652 -----GNEKKQR---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKA 2703
+E+KQR KK+ D++ L+ + E +L L+A+ +
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQMKDFQR 1666
Query: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK--EKLSILEKEDETEVQES 2761
EL + +++ E SL+ DL Q+++ LA A+ K + LEKE+
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE------- 1719
Query: 2762 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS-EEVTEI 2820
L++ +AS G + + ++ ++ + A ++ L+ E + E +++
Sbjct: 1720 ------------LAEELASSLSG--RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880
+ + T++ E++ A E ++ S + L+R++ L E G +K+ + +
Sbjct: 1766 VRKATQQAEQLSNELATE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 2881 KEGSSIPELAHSDAYQTRE 2899
+ I +L + RE
Sbjct: 1825 ALEAKIAQLEEQVEQEARE 1843
Score = 144 bits (362), Expect = 2e-33
Identities = 234/1125 (20%), Positives = 480/1125 (42%), Gaps = 130/1125 (11%)
Query: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLR---QAHMRQMERQREDQEQLQEEIK---- 1631
Q+ EE+++ EL + + Q+A L+ Q H + E + QEQLQ E +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 1632 --RLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689
+ +LA + + E ++ E E L EE + +QL A R+K+ ++ +
Sbjct: 913 AEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQ-AERKKMAQQMLDL-------- 962
Query: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETI 1749
E Q E EE ++ +L++ + + L +E + NN+L K +EE I
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK-------ERKLLEERI 1015
Query: 1750 GRHVLGILDRSSKSQSSASLIWR-----SEAEASVKSCVHEEHTRVTDESIPSY---SGS 1801
+ + K+++ L + SE E +K EE +R E + S
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK---EEKSRQELEKLKRKLEGDAS 1072
Query: 1802 DMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPE--NEELMLNISSRLQAAVEKLLE 1859
D ++ +++ E +L+++ A +D E + L L+ + L E
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 1860 AISETSSQLEHAKVTQTELMRESFRQKQEATESLKC---QEELRER-----------LHE 1905
+ + A+ + +L E K E ++L Q+ELR + L E
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 1906 ESRAREQLAVEL-SKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964
E+R+ E E+ K ++ ++ F+R LE+E + L+ L
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC------QAEKVRDD 2018
+Q+++ +++ L Q + ++++ E+ + +K+ K + EV+ +AE
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 2019 LQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQALEKQL----------EKM 2065
L K V +L +++ E ++K +T+L L ++ +L+ QL E+
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125
L+ Q D + + F ++ LE+ K RFQ E+ T++ E+ A +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 2126 SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL 2185
+ L + L D+ + + + LE + R+ +Q L + K D + EA+ +
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 2186 SLEVQL-QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2244
+ + L +A +A++ KE E+ + L+ E+L + ++V + +LE K+ T++
Sbjct: 1490 TKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 2245 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2304
+E++ + + +D+++ A +++ + L G+F + +Q ++ +Q E+ +L
Sbjct: 1549 EEMKTQLEELEDELQ----ATEDAKLRLEVNMQALKGQFERDLQARD---EQNEEKRRQL 1601
Query: 2305 QQQLKITTDNKVIEEKNELI-----RDLETQIECLMSDQECVKRNREEEIEQLNEV---I 2356
Q+QL E K + + LE ++ L + + REE I+QL ++ +
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 2357 EKLQQELAN----------IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETAN 2406
+ Q+EL + ++ A SL EAD ++ Q D+ AE+ +Q +
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSL--EADLMQLQEDLAAAER--ARKQADLEK 1717
Query: 2407 EEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELE 2466
EE+ L + N L E L+ +E+ + ++ D + K + E
Sbjct: 1718 EELA---EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 2467 VVLTEDALK---SLENQTYFKSFEENGKGSIINLETRLLQLE--------STVSAKDLEL 2515
+ E A + + +N++ + E K L ++L ++E ST++A + ++
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNK----ELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 2516 TQCYKQIKDMQEQGQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQDN 2574
Q +Q++ + Q T+ L++K L++I ++ + + Q + +A + A+ Q
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 2575 QTISSEPERTNIQNLN----QLREDELGSDISALTLRISELESQV 2615
+ + E + N N Q DE A+ ++ L+S++
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 143 bits (360), Expect = 4e-33
Identities = 248/1144 (21%), Positives = 503/1144 (43%), Gaps = 154/1144 (13%)
Query: 2394 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNV 2453
E A E +++ E +N LKE K +QLT+E L+ + ++ ++ + E + V
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE-MRV 918
Query: 2454 AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG---SIINLETRLLQLESTVSA 2510
L+ K ELE +L E + E + + + K +++LE +L + E+
Sbjct: 919 ---RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 2511 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA-VQEYAK 2569
LE +IK ++++ + K+ +K++EE+++ + + E + K
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 2570 FCQDNQTISSE------PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI 2623
++++ SE E + Q L +L+ +L D S +I++L++Q+ E+ L
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKR-KLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 2624 LEKEQV---------EIAEKN-----VLEKEKKLLELQKLLEGNE--KKQREKEKKRSPQ 2667
++E++ EIA+KN + E E + +LQ+ L+ + + EK+K+ +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 2668 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2727
++E LKT ELE +S AT+ EL + +E+ + ++ L +ET
Sbjct: 1154 ELEALKT---------------ELEDT-LDSTATQQELRAKREQEVTVLKKALDEETR-- 1195
Query: 2728 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA-CMFEPLPIKLSKSIASQTDGTL 2786
S + + ++R A+A E+L+ ++++ K+A + L K A
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248
Query: 2787 KISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEKIEKMQ---ELHAAEILDM 2842
+ + Q + K Q+ LQS+CS E ++ +K+ K+Q E + +
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQNEVESVTGMLNEA 1306
Query: 2843 ESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRS--KEGSSIPELAHSDAYQT 2897
E + I + +L + +LL+EE V LR +E +S+ + +
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 2898 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR------AVH 2951
+ + S + I L+ S+ E E F K+I+ L + A +
Sbjct: 1367 QNLERHISTLN----IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 2952 NEGMQVLSLTESPYSD---GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQR--- 3005
++ + + + D D+ Q VS ++RK + ++ K++ +K +R
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-FDQLLAEEKNISSKYADERDRA 1481
Query: 3006 EAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL----- 3060
EAE + S + E L A ++ LE + +L A +L + + D VG
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDLVS--SKDDVGKNVHEL 1537
Query: 3061 ---LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI--QALHAQMNGRKITLKREQESE 3115
LE +++E + + + LQ + L E+ QAL Q R + + EQ E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE-RDLQARDEQNEE 1596
Query: 3116 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3175
K +Q Q Q+ E + EL + +Q + +L+ +L +L+
Sbjct: 1597 KR---------RQLQRQLHEYETELEDER-------KQRALAAAAKKKLEGDLKDLELQA 1640
Query: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
++ +K + + +K+L + ++KD E+ + + SR+ +A KE K +S
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELE--------DARASRDEIFATAKENEKKAKSL 1692
Query: 3236 ERDKEEL-EDLKFSLESQKQRNLQLNLLLEQQ------KQLLNESQQKIESQRMLYDAQL 3288
E D +L EDL + ++KQ +L+ L E+ + L + ++++E++ + +L
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 3289 SEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL 3348
EEQG +E+ R+R+ + + +L +L + T Q +E ++L
Sbjct: 1753 EEEQGN-------MEAMSDRVRKATQQAE---QLSNELATERSTAQK-----NESARQQL 1797
Query: 3349 QKQLEEKHSRIVELLNETE---KYKLDSLQTR-QQMEKDRQVHRKTLQTEQEANTEGQKK 3404
++Q +E S++ E+ + K + +L+ + Q+E+ + + Q ++ + KK
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 3405 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
+ E+ +VED ++ E+ ++Q K R++ + ++ ++ E E + +RR L + L
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Query: 3465 NEPT 3468
+E T
Sbjct: 1915 DEAT 1918
Score = 133 bits (334), Expect = 4e-30
Identities = 280/1347 (20%), Positives = 551/1347 (40%), Gaps = 217/1347 (16%)
Query: 414 FETDIVQRMEQETQRKLEQLRAELDEMYG------------QQIVQMKQELIRQHMAQME 461
F T ++ +E+E K+ + M QQ+ MK +I+++ A
Sbjct: 777 FRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMK--VIQRNCAAYL 834
Query: 462 EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILE 521
+++ + ++ +T E++++ + + + Q ++ ++L+++ + E
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894
Query: 522 EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED----LKAEIVS 577
EK LQ QL+ E + + E R E E L+E L ED L+AE
Sbjct: 895 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954
Query: 578 ASESRKELELK-HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636
++ +LE + E E K++LE + + EA++++L ++L ++
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKV-------------TAEAKIKKLEDEILVMDDQN 1001
Query: 637 LSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696
KE +E RI+ L NL +++ L ++ K E+M E + + K+ +
Sbjct: 1002 NKLSKERKLLEERIS--DLTTNLA-EEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSR 1057
Query: 697 LEISKLKDLQQSLVNSKSEEMT-LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELL 755
E+ KLK + + E++ LQ + ++++ ++EE+ + L + E+ K L
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 756 EK--QMKEKENDLQEKF-AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
+K +++ +DLQE ++ A N K ++ E++ + T + LDS ++
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT-----LDSTATQ 1172
Query: 813 SK-DSVWEKEIEIL---IEEN--------EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
+ + E+E+ +L ++E ++++Q+ Q EE+ +Q F A+ N + N
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
Q L++E A L L + KQE+E+K K ++ +++S D +
Sbjct: 1233 KQTLEKENADLAGELRVL--GQAKQEVEHKKK-----------KLEAQVQELQSKCSDGE 1279
Query: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980
+ AE + ++ + + L + + ++L++ ++ LS QL+ L EE
Sbjct: 1280 RA-RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEET 1335
Query: 981 KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1040
+ +K VS + R+LE E S Q+ ++ + E +S +N
Sbjct: 1336 R----QKLNVSTKLRQLE--------EERNSLQDQLDEEME-----AKQNLERHISTLNI 1378
Query: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100
+ K + + + E + G++ Q++ + ++T++ +A + DKL+K N
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKE-----IENLTQQYEEKA---AAYDKLEKTKN 1430
Query: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTH--VDQVREYMENEKDKALCSLKEELIFAQEEKI 1158
L+ E +DL + ++ QR +S + DQ+ +N K A+E++
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 1159 KELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218
K L LE + ++ +E + K+ KA E
Sbjct: 1491 KALSLARALE-EALEAKEELER-------TNKMLKAEME--------------------- 1521
Query: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY----NKLLVLQ 1274
D +S D + +N EL+ + ++ E M T L ++ +E + L L+
Sbjct: 1522 -------DLVSSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 1275 TRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKT 1334
+ + GQ ++ E+N K +H T LED + K +L K
Sbjct: 1574 VNMQALKGQFERDLQAR-DEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKK 1627
Query: 1335 KLEEQVQELE----SLISSLQQQLKETEQNYEAEIHCLQKRLQ------------AVSES 1378
KLE +++LE S I ++ +K+ + +A++ Q+ L+ A
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 1379 TVPPSLPVDSVVITE--SDAQRTMYPGSCVKKNIDGTI--EFSGEFGVKEETNIVKLLEK 1434
SL D + + E + A+R K+ + + SG +++E ++
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494
Q +E+LEEE G E A S + QQ + NE L+
Sbjct: 1747 QLEEELEEE---------------------QGNME--AMSDRVRKATQQAEQLSNE--LA 1781
Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFS 1554
++ Q E+ + + + K L +L E + E+K L E +
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 1555 KDKTFIVRQSIHDEISVSSMDAS-RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHM 1613
++K + S+ D ++++L Q+ED R ++ QY+E + A +
Sbjct: 1842 REKQAATK-------SLKQKDKKLKEILL---QVEDER-KMAEQYKEQAEK----GNARV 1886
Query: 1614 RQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE-NLVSERERVLLEELEALKQLSLAGRE 1672
+Q++RQ E+ E EE +R+N A R + E + +E + E+ ALK G E
Sbjct: 1887 KQLKRQLEEAE---EESQRIN---ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Query: 1673 KLCCELRNSSTQTQNGNENQGEVEEQT 1699
R S + N + E E T
Sbjct: 1941 TSFVPSRRSGGRRVIENADGSEEETDT 1967
Score = 132 bits (331), Expect = 9e-30
Identities = 239/1148 (20%), Positives = 501/1148 (43%), Gaps = 119/1148 (10%)
Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
++RQ+E M+A+ E +L + E+ K + E++ + E+ L ++ L+ ++ +
Sbjct: 854 VTRQEEEMQAK----EDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR----EHERDVFQQEIQKLE 2091
+ E E+ + + L + Q LE+ L +M L+E+ DR + ER Q++ LE
Sbjct: 909 LYAEAEEMR----VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLE 963
Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151
+QL+ + + Q ++E++ K K + E+L+ +Q + +ER + LE
Sbjct: 964 EQLE-----EEEAARQKLQLEKVTAEAKIKKLE-DEILVMDDQNNKLSKER----KLLEE 1013
Query: 2152 RVRELEQALLVSADTFQKVEDRKHFGAVEAKPE---LSLEVQLQAERDAIDRKEKEITNL 2208
R+ +L + + ++ E K+ ++ K E LEV+L+ E + EK L
Sbjct: 1014 RISDL------TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2268
E F E++ + ++ +L MQL +++E L L+ E + ++K I+E
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK----IREL 1123
Query: 2269 DAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLE 2328
+ + Q L + A + ++ + D L E++ L+ +L+ T D+ +++ R+ E
Sbjct: 1124 EGHISDLQEDLDSERAARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 2329 TQIECLMSDQEC---------VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2379
+ D+E +++ + +E+L E +E+ ++ AN+ + N +L +
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK----NKQTLEK 1238
Query: 2380 EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERES 2439
E L +L V+ K +E + + ++ +++ + +L ++ L+ E ES
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1298
Query: 2440 VEKIQSIPE-NSVNVAID--HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIIN 2496
V + + E ++ +A D LS + + +L E+ + L T + EE
Sbjct: 1299 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ 1358
Query: 2497 LETRL---LQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIV 2547
L+ + LE +S +++L+ K+++D E+G+ + QK+I NL +
Sbjct: 1359 LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK---KRFQKEIENLTQQY 1415
Query: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2607
EEK AA +LE + + D+ + + +R + NL + + +
Sbjct: 1416 EEKAAA----YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR------------K 1459
Query: 2608 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ 2667
+L ++ + + E+++ AE EKE K L L + LE + + E E+
Sbjct: 1460 FDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 2668 DVEVLKTTTELFHSNEESG-FFNELE----ALRAESVATKAELASYKEKAEKLQEELLVK 2722
E+ +L S ++ G +ELE AL + K +L +++ + ++ L
Sbjct: 1517 KAEM----EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 2723 ETNMTSL----QKDLSQVRDHLAEAKEKLSILEKEDETEVQ-ESKKACMFEPLPIKLS-- 2775
E NM +L ++DL + E + +L E ETE++ E K+ + KL
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 2776 -KSIASQTDGTLK--ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQ 2832
K + Q D +K + Q ++ + Q L+ +S + EI + E +K +
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD--EIFATAKENEKKAK 1690
Query: 2833 ELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHS 2892
L A+++ ++ ++ E +++ + + L EE + + L+ ++ +A
Sbjct: 1691 SLE-ADLMQLQ-EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 2893 DAYQTREICSSDSGSD-WGQGIYLTHSQGFDIASE-GRGEESESATDSFPKKIKGLLRAV 2950
+ E + ++ SD + ++A+E +++ESA ++ K L +
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1808
Query: 2951 HNEGMQVLSLTESPYS--DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE 3008
H V S +S + + + +++ E E++A ++ + ++ LQ E E
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 3009 VYDSSQSHESFSDWRGEL-LLALQQVFLEERSVLLAAFRTEL-----TALGTTDAVGL-L 3061
+ Q E + L Q EE S + A R +L A + +A+G +
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928
Query: 3062 NCLEQRIQ 3069
N L+ +++
Sbjct: 1929 NALKSKLR 1936
Score = 131 bits (329), Expect = 1e-29
Identities = 213/1071 (19%), Positives = 450/1071 (42%), Gaps = 162/1071 (15%)
Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
E+E+R ++L+A + K+AQ + + + +QK + + +++ + D +
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
N + +E + +T E + + ES IS E
Sbjct: 1000 QNNKLSKERKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE---- 1053
Query: 122 SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
++ + L+ + G + EQ A D + ++ +LA K+ E++ L++
Sbjct: 1054 ---EKSRQELEKLKRKLEGDASDFHEQIA-DLQAQIAELKMQLAKKEEELQAALARLDD- 1108
Query: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
+ L++++E E G I+ L +L R +++ ++ +L E+ + L+ +
Sbjct: 1109 EIAQKNNALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161
Query: 242 F----------QQLQASE-----TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLED 286
Q+L+A L+ + T + Q ++ H Q +EE LE
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 287 YQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----ETIIEELNTKIIEEE 342
+++ K + L+++ ++ + +V K+E++ K E ++EL +K + E
Sbjct: 1222 FKRAKANLDKNKQTLEKENA--DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 343 KKTLELKDK-------LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIK 395
+ EL DK + + +L E + + ++ +++ ++ +L ++++ EE +
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETR 1336
Query: 396 QLMGTVEELQKRNHKDSQFETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Q + +L++ + + + + + ME Q +R + L +L + + K +
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQDF 1390
Query: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNIKLQDTNSQKEKL 512
+ +EE K R + E+EN + Y D++ K N EL+ + D ++Q++ +
Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450
Query: 513 KEELGLILEEKCALQRQLEDLV-EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL 571
LE+K QR+ + L+ EE + S + + AE K K+LS L
Sbjct: 1451 SN-----LEKK---QRKFDQLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARAL 1499
Query: 572 KAEIVSASESRKELELKHEAEVTNYKIKLEM--LEKEKNAV------LDRMAESQEAELE 623
+ + LE K E E TN +K EM L K+ V L++ + E ++E
Sbjct: 1500 E----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK----------DNLGIHYKQQIDGLQNE 673
++TQL E+ + ED ++ +N++ LK D ++Q+ +E
Sbjct: 1550 EMKTQL--EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 674 MSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE------EMTLQINELQKE 727
++E + ++ + +L ++ L+ S + + E ++ Q+ + Q+E
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 728 IEILR-----------QEEKEKGTLEQEVQELQ---LKTELLEKQMKEKENDLQEKFAQL 773
+E R + EK+ +LE ++ +LQ E KQ ++ +L E+ A
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 774 EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK 833
+ + L+DEK+ LE + +EE + +E + +
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEE-----------------QGNMEAMSDRVRKAT 1770
Query: 834 QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL 893
QQ QL+ E+ +R+T A+KN E Q+L+ + +++ L + + + ++KS +
Sbjct: 1771 QQAEQLSNELATERST---AQKN-ESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTI 1823
Query: 894 KAL-----------NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942
AL +E ++ ++K K E V + +M E ++ +
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Query: 943 EKLEVTKR---EKLELSQRLSDLSEQLKQKHGEISFLNE----EVKSLKQE 986
+++ KR E E SQR++ +L+++ E + NE EV +LK +
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 122 bits (306), Expect = 7e-27
Identities = 253/1214 (20%), Positives = 509/1214 (41%), Gaps = 161/1214 (13%)
Query: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143
++E+Q E +L+ Q +E++ +E+EQ + L E+ + E L ++ +L + +E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 2144 EEI----EKLEFRVRELEQALLVSADTFQKVE-DRKHFGAVEAKPELSLEVQLQAERDAI 2198
+ ++LE + E+E L D Q+++ +RK A+ L LE QL+ E A
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM----AQQMLDLEEQLEEEEAAR 973
Query: 2199 DRKEKEITNLEEQLEQFREEL---ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2255
+ + E E ++++ +E+ +++N ++ + LE + + TT L E E++ K
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 2256 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2315
K I E + +++ + ++ ++ E + +EQ+ LQ Q
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQ-------- 1084
Query: 2316 VIEEKNELIRDLETQIECL--MSDQECVKRNREEEIEQLNEVIEKLQQELAN---IGQKT 2370
+ E K +L + E L + D+ K N ++I +L I LQ++L + K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 2371 SMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE-EMTFMKNVLKETNFKMNQLTQE 2429
L EE ++LK +L+ + + A +Q++ E E+T +K L E QE
Sbjct: 1145 EKQKRDLGEELEALKTELEDTL-DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 2430 LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEEN 2489
+ ++ ++VE++ E A +L K+K LE +EN
Sbjct: 1204 M--RQKHAQAVEELTEQLEQFKR-AKANLDKNKQTLE--------------------KEN 1240
Query: 2490 GKGSIINLETRLL-QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
+ E R+L Q + V K +L ++++ G+ L K+ LQ VE
Sbjct: 1241 AD---LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 2549 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRI 2608
V+ + EA + K +D ++SS+ +Q+ +L ++E ++ T ++
Sbjct: 1298 S------VTGMLNEAEGKAIKLAKDVASLSSQ-----LQDTQELLQEETRQKLNVST-KL 1345
Query: 2609 SELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE--GNEKKQREKEKKRSP 2666
+LE + + L E E + E+++ +L + +K L+ + + E+ KKR
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405
Query: 2667 QDVEVLKTTTELFHSNEESGFFNELEALRAE----------SVATKAELASYKEKAEKLQ 2716
+++E L E E++ +++LE + + + +L S EK ++
Sbjct: 1406 KEIENLTQQYE-----EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 2717 EELLVKETNMTSLQKDLSQVRDHL-AEAKEK----LSILEKEDETEVQESKKACMFEPLP 2771
++LL +E N++S D RD AEA+EK LS+ +E + + + L
Sbjct: 1461 DQLLAEEKNISSKYAD---ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 2772 IKLSKSIASQTD---GTLKISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEK 2827
++ ++S+ D ++ S + + ++ Q+ L+ E + E ++ + +
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577
Query: 2828 IEKMQ---ELHAAEILDMESR---------HISETETLKREHYVAVQLLKEECGTLKAV- 2874
K Q +L A + + E R + +E E +++ +A K+ G LK +
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 2875 IQCLRSKEG--SSIPELAHSDAYQT---REICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2929
+Q + +G +I +L A RE+ + + D I+ T + +E +
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD---EIFATAKE-----NEKKA 1689
Query: 2930 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2989
+ E+ + + RA ++ L E S + Q + LE R A
Sbjct: 1690 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA--- 1746
Query: 2990 TISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTEL 3049
Q E E+ + + E+ SD + A QQ E+ S LA R+
Sbjct: 1747 --------------QLEEELEEEQGNMEAMSD---RVRKATQQA--EQLSNELATERS-- 1785
Query: 3050 TALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLK 3109
TA A Q+++ Q E ++ + ++ A + S I AL A++ L+
Sbjct: 1786 TAQKNESA-------RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI----AQLE 1834
Query: 3110 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA 3169
+ E E ++ +++QK ++ E+ +++ + A + +EQ V +LK +L
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894
Query: 3170 QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA 3229
+ + E + + K +EL+ E + + + + L S+ ++ E + +
Sbjct: 1895 EAEEESQRINANRRKLQRELD----EATESNEAMGREVNALKSKLRRGNETSFVPSRRSG 1950
Query: 3230 KLGRSEERDKEELE 3243
E D E E
Sbjct: 1951 GRRVIENADGSEEE 1964
Score = 117 bits (292), Expect = 3e-25
Identities = 242/1207 (20%), Positives = 495/1207 (41%), Gaps = 201/1207 (16%)
Query: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
+++ L + +EE + KED ++K K+ +Q+ + E+ QK +
Sbjct: 847 KVKPLLQVTRQEEEMQAKED-------ELQKTKER-----QQKAENELKELEQKHSQLTE 894
Query: 684 EKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGT-L 741
EK NL+ +Q Q E+ ++ ++++ L K E + E+ E+E +EE+++G L
Sbjct: 895 EK-NLLQEQLQAETELYAEAEEMRVRLAAKKQE-----LEEILHEMEARLEEEEDRGQQL 948
Query: 742 EQEVQELQLKTELLEKQMKEKE-----------------NDLQEKFAQLEAENSILKDEK 784
+ E +++ + LE+Q++E+E L+++ ++ +N+ L E+
Sbjct: 949 QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844
K LE+ + T EE + K K+K E+E+ +++ E +Q+ +L ++E
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 845 KQRNTFSFAEKNFEVNYQEL--------QEEYACLLKVKDDLEDSKN--KQELEYKSKLK 894
+ F + + EL +E A L ++ D++ N K+ E + +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 895 ALNEELHLQRINPTTVKMKSSVFDED----KTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
L E+L +R + + E+ KT + +TL+ ++ + +++ V K+
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 951 EKLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENV 1009
E ++ ++++QKH + + L E+++ K+ K + + LE EN
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-------KENA 1241
Query: 1010 Q-SCDTQVSSLLDGVVTMTSRGAEGSVSKVNK--SFGEESKIMVEDKV--------SFEN 1058
+ + +V V + E V ++ S GE ++ + DKV S
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 1059 MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRI 1118
M E K +L D + S L+ TQ ++ +++LNV LR Q+E +R
Sbjct: 1302 MLNEAEGKAIKLAKD---VASLSSQLQDTQELLQEETRQKLNV----STKLR-QLEEERN 1353
Query: 1119 CLSLVYSTHVDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176
L DQ+ E ME ++ ++ + +L +L + K+LQ T E
Sbjct: 1354 SLQ-------DQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDF-------ASTVE 1395
Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYIS 1235
+EGK + QK + E T + + A DK E + + +
Sbjct: 1396 ALEEGKK------RFQKEI----------------ENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 1236 ENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEE 1295
+ D + D D Q + + L K ++++LL + +S + + D + E E+
Sbjct: 1434 QELDDLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 1296 -----NLPKEETEFLSIHSQM--------TNLEDIDVNHKSKLSSLQDLEKTK--LEEQV 1340
+L + E L ++ +ED+ + ++ +LEK+K LE Q+
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 1341 QELESLISSLQQQLKETEQ-------NYEAEIHCLQKRLQAVSEST------VPPSLPVD 1387
+E+++ + L+ +L+ TE N +A ++ LQA E + L
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 1388 SVVITESDAQRTMYPGSCVKKNIDG---TIEFSGEFGVKEETNIVKLLE------KQYQE 1438
+ + QR + + KK ++G +E + +K +K L K +Q
Sbjct: 1609 ETELEDERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGG----KENTASSKQAHAVCQQEQHYFNEMKLS 1494
+LE+ A + A + + + +E+ A++++A E+ E +L+
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE-ELA 1725
Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKEL-GEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553
G + + + L +EL E G +S+ +++ ++ E
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 1554 SKDKTFIVRQ-----------SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ 1602
+ K RQ +H+ + E ++ + +++ ++ +E Q
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 1603 QATELLRQAHMR------QMERQREDQEQLQEE-------IKRLNRQLAQRSSIDNENLV 1649
AT+ L+Q + Q+E +R+ EQ +E+ +K+L RQL + + +++ +
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EEAEEESQRIN 1904
Query: 1650 SERERVLLEELEALKQLSLAGRE--KLCCELRNSSTQTQNGNENQG---EVEEQTFKEKE 1704
+ R ++ E EA + GRE L +LR + + + G +E E+E
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1964
Query: 1705 LDRKPED 1711
D + D
Sbjct: 1965 TDTRDAD 1971
Score = 82.8 bits (203), Expect = 6e-15
Identities = 170/823 (20%), Positives = 351/823 (42%), Gaps = 127/823 (15%)
Query: 2931 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2990
++E+ + ++++ L A E ++L E+ + ED Q +E RK
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-----RKKMAQQ 958
Query: 2991 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL--------LALQQVFLEERSVLL 3042
+ L++ + + + R+ + + E+L L+ ++ LEER L
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 3043 AAFRTE-------LTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSE 3093
E LT L +++ LE R++++ Q + +K D +
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHE-SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 3094 IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3153
I L AQ+ K+ L +++E + + L+ I QK + + +++ ++ ++LQE
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQED 1133
Query: 3154 LSSEKMV-------VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3206
L SE+ +L EL K ELE TL + +EL A R + EV +L
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVL 1186
Query: 3207 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK---FSLESQKQRNLQLNLLL 3263
L E+ +S E Q +++ + K ++ E E+LE K +L+ KQ + N L
Sbjct: 1187 KKAL-DEETRSHEAQ--VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243
Query: 3264 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3323
+ ++L +++Q++E ++ +AQ+ E Q + + E+ R + D+ +L
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSK------CSDGERAR----AELNDKVHKLQ 1293
Query: 3324 AQLQSSDGT---GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3380
+++S G + + ++D+ L QL++ ELL E + KL+ +Q+
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQ----ELLQEETRQKLNVSTKLRQL 1348
Query: 3381 EKDRQVHRKTLQTEQEAN--------------TEGQKKMHE--------------LQSKV 3412
E++R + L E EA ++ +KK+ + Q ++
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408
Query: 3413 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF------QKQELEREEKRESR--RILYQNL 3464
E+L +Q EEK KL+ RLQ + + Q+Q + EK++ + ++L +
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 3465 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELE----MIRQKLQ 3520
N + ++ DR + E ETK + A+ +E ELE M++ +++
Sbjct: 1469 NISSKYADERDRAE----AEAREKETKALSLARALE---EALEAKEELERTNKMLKAEME 1521
Query: 3521 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ-QGEEPSLVSPST 3579
+ S + + E + + A ++ ++E+ QL++L + Q E + +
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQLEELEDELQATEDAKLRLEV 1574
Query: 3580 SCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3639
+ +L + R +L Q E++ L+ + + E ++ R+ A +++ L
Sbjct: 1575 NMQALKGQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLE 1630
Query: 3640 GGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
G + + ++ + RE+ K L++ +A++ + EL +
Sbjct: 1631 GDLK-DLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELED 1670
Score = 76.3 bits (186), Expect = 6e-13
Identities = 119/577 (20%), Positives = 241/577 (41%), Gaps = 64/577 (11%)
Query: 3161 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK---KS 3217
V + E+ + EL+ T + Q K EL+ + T+E +LL + L +E + ++
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 3218 RELQWALEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3274
E++ L +K +L E EE ED L++++++ Q L LE+Q + ++
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 3275 QKIESQRMLYDAQLS---------EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3325
QK++ +++ +A++ ++Q L + L E RI ++++ L E E
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE--RISDLTTNLAEEEEKAKN 1031
Query: 3326 LQSSDGTGQS---------RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3376
L +S + S L++L+++LE S E + + + +
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 3377 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE---- 3432
+ E++ Q L E KK+ EL+ + DLQ L+ +R K + +
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 3433 GQRLQGIMQEFQ--------KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3484
G+ L+ + E + +QEL R ++ + +L + L+E T + Q
Sbjct: 1152 GEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 3485 KIEGETKESNYAKLIEMN---------GGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3535
+E T++ K + N EL ++ Q Q V K + L + E
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 3536 RLQFETADDEDF-IWVQENIDEIILQLQKLTGQQGE-EPSLVSPSTSCGSLTERL----- 3588
LQ + +D E + + + ++ +++ +TG E E + + SL+ +L
Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329
Query: 3589 -----LRQNAELTGHISQLTEEKNDLRNMV---MKLEEQIRWYRQTGAGRDNSSRFSLNG 3640
RQ ++ + QL EE+N L++ + M+ ++ + + T + + S+ L
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 3641 GANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLK 3677
A+ + K+ + +E L + + A KL+
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Score = 71.6 bits (174), Expect = 1e-11
Identities = 92/466 (19%), Positives = 200/466 (42%), Gaps = 52/466 (11%)
Query: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240
A + L+ + +RL K K LL T E+ +++E + KE+ + +E ++ E
Sbjct: 831 AAYLKLRNWQWWRLFTKVKP----LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 886
Query: 3241 E----LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3296
+ L + K L+ Q Q +L E+ + L +Q++E +A+L EE+ R
Sbjct: 887 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 946
Query: 3297 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL---------LKE 3347
+LQ + ++ ++ L+ E +LQ T +++ +++ L +
Sbjct: 947 QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
Query: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3407
+K LEE+ S + L E E+ + + + + E L+ E+++ E +K +
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 3408 LQSKVEDLQRQLEEKRQQVYKLDLE----GQRLQGIMQEFQKQELEREEKRESRRILYQN 3463
L+ D Q+ + + Q+ +L ++ + LQ + + ++ + R L +
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126
Query: 3464 LNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ--- 3520
+++ LQ+ ++ E N A+ + + G ELE ++ +L+
Sbjct: 1127 ISD---------------LQEDLDSERAARNKAEKQKRDLG-----EELEALKTELEDTL 1166
Query: 3521 -CVASKLQVLPQKASERLQFETADDEDF----IWVQENIDEIILQLQKLTGQQGEEPSLV 3575
A++ ++ ++ E + A DE+ VQE + +++LT Q +
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ---FK 1223
Query: 3576 SPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3621
+ + L ++NA+L G + L + K ++ + KLE Q++
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269
Score = 70.5 bits (171), Expect = 3e-11
Identities = 90/425 (21%), Positives = 184/425 (43%), Gaps = 61/425 (14%)
Query: 169 HEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ----------QAR 218
HE+E+ R LE T E QL+E E ++ + +L N+Q QAR
Sbjct: 1535 HELEKSKRALE----TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590
Query: 219 REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADL----LQAKQQILTHQ 274
E++E R +L Q + + + + + L + DL LQA I +
Sbjct: 1591 DEQNEEKRR--QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 275 Q---QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331
+ QL + ++D+Q++ ED +++I E +KK ++ + +Q +E +
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARAS----RDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Query: 332 EELNTKI---IEEEKKTLELKDKLTTADKLLGE---LQEQIVQKNQEIKNMKLELTNSKQ 385
+ +E+E+ EL L+ + L E L+ +I Q +E++ + +
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 386 KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQI 445
+ R+++++ +QL + + K+ + Q+ +R+ ++LR++L EM G
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGAVK 1816
Query: 446 VQMKQEL--IRQHMAQMEEMKTRHKGEMENALRSYSN--------ITVNEDQIKLMNVAI 495
+ K + + +AQ+EE + E + A +S + ED+ K+
Sbjct: 1817 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1876
Query: 496 NEL---NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE-------ELSFSREQIQ 545
+ N +++ Q E+ +EE I + LQR+L++ E E++ + +++
Sbjct: 1877 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Query: 546 RARQT 550
R +T
Sbjct: 1937 RGNET 1941
Score = 58.5 bits (140), Expect = 1e-07
Identities = 91/505 (18%), Positives = 214/505 (42%), Gaps = 75/505 (14%)
Query: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63
E++Q+K + A+ + A ++ ++ ++K+ K S + + + + N
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513
Query: 64 EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
+M +E V + + + +H E+ ++ ++E E+ T ++ E+
Sbjct: 1514 KML---KAEMEDLVSSKDDVGKNVH--ELEKSKRALETQME-EMKTQLEELEDELQATED 1567
Query: 124 V-MRTGKPTNLLR---EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI-------E 172
+R L+ E + D +E+ + L E+EL ++ + +
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1627
Query: 173 ELNRELEEMRVTYGT------EGLQQLQEFEAAIKQ-----------RDGIITQLTANLQ 215
+L +L+++ + + E ++QL++ +A +K RD I N +
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687
Query: 216 QARREKDETMR--EFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA--DLLQAKQQIL 271
+A+ + + M+ E L E+++K Q ++ + +E L +S A + + + +I
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARK-QADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 272 THQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331
+++LEE+ +E + T Q L E+ ++ N+ Q+ E
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSN-----ELATERSTAQKNESARQQLERQN 1801
Query: 332 EELNTKIIEEEKKTL-ELKDKLTTADKLLGELQEQIVQ--------------KNQEIKNM 376
+EL +K+ E E + K + + + +L+EQ+ Q K++++K +
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 377 KLELTNSKQKERQSSEE-------IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
L++ + ++ Q E+ +KQL +EE ++ E+ + ++ QR+
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--------ESQRINANRRKLQRE 1913
Query: 430 LEQLRAELDEMYGQQIVQMKQELIR 454
L++ E +E G+++ +K +L R
Sbjct: 1914 LDE-ATESNEAMGREVNALKSKLRR 1937
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.325
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 130,988,532
Number of Sequences: 37866
Number of extensions: 6234353
Number of successful extensions: 116445
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 740
Number of HSP's successfully gapped in prelim test: 1742
Number of HSP's that attempted gapping in prelim test: 28879
Number of HSP's gapped (non-prelim): 36081
length of query: 3907
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3785
effective length of database: 13,627,866
effective search space: 51581472810
effective search space used: 51581472810
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.