Guide to the Human Genome
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Search of human proteins with 224831248

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]
         (978 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]                1950   0.0  
gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]                1932   0.0  
gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]                1907   0.0  
gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]                1888   0.0  
gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]                 1865   0.0  
gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]                 1847   0.0  
gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]                 1781   0.0  
gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]                 1763   0.0  
gi|56549125 dynamin 2 isoform 4 [Homo sapiens]                        114   4e-25
gi|56549123 dynamin 2 isoform 2 [Homo sapiens]                        114   4e-25
gi|56549121 dynamin 2 isoform 1 [Homo sapiens]                        114   4e-25
gi|56549119 dynamin 2 isoform 3 [Homo sapiens]                        114   4e-25
gi|56549117 dynamin 1 isoform 2 [Homo sapiens]                        107   5e-23
gi|59853099 dynamin 1 isoform 1 [Homo sapiens]                        107   5e-23
gi|171460914 dynamin 1-like isoform 1 [Homo sapiens]                  104   4e-22
gi|171460918 dynamin 1-like isoform 3 [Homo sapiens]                  104   4e-22
gi|171460916 dynamin 1-like isoform 2 [Homo sapiens]                  104   4e-22
gi|42544243 dynamin 3 isoform a [Homo sapiens]                        103   8e-22
gi|209915561 dynamin 3 isoform b [Homo sapiens]                       103   8e-22
gi|222136619 myxovirus resistance protein 1 [Homo sapiens]            102   2e-21
gi|222136617 myxovirus resistance protein 1 [Homo sapiens]            102   2e-21
gi|11342664 myxovirus resistance protein 2 [Homo sapiens]              99   3e-20
gi|110611228 utrophin [Homo sapiens]                                   41   0.006
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     39   0.018
gi|187761324 shootin1 isoform a [Homo sapiens]                         39   0.018
gi|50511340 shootin1 isoform b [Homo sapiens]                          39   0.018
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo...    39   0.024
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo...    39   0.024
gi|28173564 keratin 73 [Homo sapiens]                                  39   0.031
gi|148612803 keratin 6 irs4 [Homo sapiens]                             38   0.053

>gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]
          Length = 978

 Score = 1950 bits (5052), Expect = 0.0
 Identities = 978/978 (100%), Positives = 978/978 (100%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180

Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 240
           DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL
Sbjct: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 240

Query: 241 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 300
           LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY
Sbjct: 241 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 300

Query: 301 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 360
           NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK
Sbjct: 301 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 360

Query: 361 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 420
           DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV
Sbjct: 361 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 420

Query: 421 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 480
           INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT
Sbjct: 421 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 480

Query: 481 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 540
           IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF
Sbjct: 481 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 540

Query: 541 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 600
           FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY
Sbjct: 541 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 600

Query: 601 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 660
           PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ
Sbjct: 601 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 660

Query: 661 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 720
           TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE
Sbjct: 661 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 720

Query: 721 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 780
           AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA
Sbjct: 721 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 780

Query: 781 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 840
           IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE
Sbjct: 781 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 840

Query: 841 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 900
           SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR
Sbjct: 841 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 900

Query: 901 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 960
           IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV
Sbjct: 901 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 960

Query: 961 REIQEKLDAFIEALHQEK 978
           REIQEKLDAFIEALHQEK
Sbjct: 961 REIQEKLDAFIEALHQEK 978


>gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]
          Length = 1015

 Score = 1932 bits (5004), Expect = 0.0
 Identities = 978/1015 (96%), Positives = 978/1015 (96%), Gaps = 37/1015 (3%)

Query: 1    MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
            MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1    MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61   QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
            QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61   QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121  QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
            QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK
Sbjct: 121  QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180

Query: 181  DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHF---------------- 224
            DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHF                
Sbjct: 181  DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240

Query: 225  ---------------------RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 263
                                 RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 241  EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300

Query: 264  LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 323
            LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 301  LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360

Query: 324  EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 383
            EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 361  EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420

Query: 384  RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 443
            RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 421  RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480

Query: 444  MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 503
            MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 481  MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540

Query: 504  IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 563
            IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 541  IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600

Query: 564  LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 623
            LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 601  LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660

Query: 624  ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 683
            ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 661  ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720

Query: 684  PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 743
            PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 721  PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780

Query: 744  QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 803
            QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 781  QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840

Query: 804  CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 863
            CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 841  CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900

Query: 864  LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 923
            LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 901  LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960

Query: 924  LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 978
            LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 961  LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015


>gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]
          Length = 960

 Score = 1907 bits (4939), Expect = 0.0
 Identities = 960/978 (98%), Positives = 960/978 (98%), Gaps = 18/978 (1%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180

Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 240
           DFFTSG                  SPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL
Sbjct: 181 DFFTSG------------------SPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 222

Query: 241 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 300
           LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY
Sbjct: 223 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 282

Query: 301 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 360
           NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK
Sbjct: 283 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 342

Query: 361 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 420
           DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV
Sbjct: 343 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 402

Query: 421 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 480
           INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT
Sbjct: 403 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 462

Query: 481 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 540
           IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF
Sbjct: 463 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 522

Query: 541 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 600
           FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY
Sbjct: 523 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 582

Query: 601 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 660
           PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ
Sbjct: 583 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 642

Query: 661 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 720
           TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE
Sbjct: 643 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 702

Query: 721 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 780
           AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA
Sbjct: 703 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 762

Query: 781 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 840
           IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE
Sbjct: 763 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 822

Query: 841 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 900
           SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR
Sbjct: 823 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 882

Query: 901 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 960
           IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV
Sbjct: 883 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 942

Query: 961 REIQEKLDAFIEALHQEK 978
           REIQEKLDAFIEALHQEK
Sbjct: 943 REIQEKLDAFIEALHQEK 960


>gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]
          Length = 997

 Score = 1888 bits (4891), Expect = 0.0
 Identities = 960/1015 (94%), Positives = 960/1015 (94%), Gaps = 55/1015 (5%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180

Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRK-------------- 226
           DFFTSG                  SPEETAFRATDRGSESDKHFRK              
Sbjct: 181 DFFTSG------------------SPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 222

Query: 227 -----------------------VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 263
                                  VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 223 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 282

Query: 264 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 323
           LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 283 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 342

Query: 324 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 383
           EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 343 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 402

Query: 384 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 443
           RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 403 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 462

Query: 444 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 503
           MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 463 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 522

Query: 504 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 563
           IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 523 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 582

Query: 564 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 623
           LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 583 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 642

Query: 624 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 683
           ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 643 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 702

Query: 684 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 743
           PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 703 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 762

Query: 744 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 803
           QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 763 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 822

Query: 804 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 863
           CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 823 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 882

Query: 864 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 923
           LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 883 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 942

Query: 924 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 978
           LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 943 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 997


>gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]
          Length = 942

 Score = 1865 bits (4831), Expect = 0.0
 Identities = 942/978 (96%), Positives = 942/978 (96%), Gaps = 36/978 (3%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDF                               
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDF------------------------------- 149

Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 240
                GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL
Sbjct: 150 -----GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 204

Query: 241 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 300
           LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY
Sbjct: 205 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 264

Query: 301 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 360
           NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK
Sbjct: 265 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 324

Query: 361 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 420
           DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV
Sbjct: 325 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 384

Query: 421 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 480
           INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT
Sbjct: 385 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 444

Query: 481 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 540
           IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF
Sbjct: 445 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 504

Query: 541 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 600
           FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY
Sbjct: 505 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 564

Query: 601 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 660
           PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ
Sbjct: 565 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 624

Query: 661 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 720
           TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE
Sbjct: 625 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 684

Query: 721 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 780
           AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA
Sbjct: 685 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 744

Query: 781 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 840
           IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE
Sbjct: 745 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 804

Query: 841 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 900
           SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR
Sbjct: 805 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 864

Query: 901 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 960
           IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV
Sbjct: 865 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 924

Query: 961 REIQEKLDAFIEALHQEK 978
           REIQEKLDAFIEALHQEK
Sbjct: 925 REIQEKLDAFIEALHQEK 942


>gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]
          Length = 979

 Score = 1847 bits (4783), Expect = 0.0
 Identities = 942/1015 (92%), Positives = 942/1015 (92%), Gaps = 73/1015 (7%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDF                               
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDF------------------------------- 149

Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRK-------------- 226
                GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRK              
Sbjct: 150 -----GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 204

Query: 227 -----------------------VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 263
                                  VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 205 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 264

Query: 264 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 323
           LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 265 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 324

Query: 324 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 383
           EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 325 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 384

Query: 384 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 443
           RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 385 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 444

Query: 444 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 503
           MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 445 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 504

Query: 504 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 563
           IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 505 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 564

Query: 564 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 623
           LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 565 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 624

Query: 624 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 683
           ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 625 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 684

Query: 684 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 743
           PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 685 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 744

Query: 744 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 803
           QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 745 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 804

Query: 804 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 863
           CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 805 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 864

Query: 864 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 923
           LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 865 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 924

Query: 924 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 978
           LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 925 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 979


>gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]
          Length = 924

 Score = 1781 bits (4613), Expect = 0.0
 Identities = 906/978 (92%), Positives = 913/978 (93%), Gaps = 54/978 (5%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
           QWKDMIP              ++ EY                                  
Sbjct: 121 QWKDMIP--------------DLSEY---------------------------------- 132

Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 240
                   +V +++   D  +  GSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL
Sbjct: 133 ------KWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 186

Query: 241 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 300
           LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY
Sbjct: 187 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 246

Query: 301 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 360
           NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK
Sbjct: 247 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 306

Query: 361 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 420
           DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV
Sbjct: 307 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 366

Query: 421 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 480
           INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT
Sbjct: 367 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 426

Query: 481 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 540
           IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF
Sbjct: 427 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 486

Query: 541 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 600
           FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY
Sbjct: 487 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 546

Query: 601 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 660
           PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ
Sbjct: 547 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 606

Query: 661 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 720
           TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE
Sbjct: 607 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 666

Query: 721 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 780
           AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA
Sbjct: 667 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 726

Query: 781 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 840
           IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE
Sbjct: 727 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 786

Query: 841 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 900
           SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR
Sbjct: 787 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 846

Query: 901 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 960
           IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV
Sbjct: 847 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 906

Query: 961 REIQEKLDAFIEALHQEK 978
           REIQEKLDAFIEALHQEK
Sbjct: 907 REIQEKLDAFIEALHQEK 924


>gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]
          Length = 961

 Score = 1763 bits (4565), Expect = 0.0
 Identities = 906/1015 (89%), Positives = 913/1015 (89%), Gaps = 91/1015 (8%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
           QWKDMIP              ++ EY                                  
Sbjct: 121 QWKDMIP--------------DLSEY---------------------------------- 132

Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRK-------------- 226
                   +V +++   D  +  GSPEETAFRATDRGSESDKHFRK              
Sbjct: 133 ------KWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 186

Query: 227 -----------------------VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 263
                                  VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 187 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 246

Query: 264 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 323
           LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 247 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 306

Query: 324 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 383
           EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 307 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 366

Query: 384 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 443
           RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 367 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 426

Query: 444 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 503
           MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 427 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 486

Query: 504 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 563
           IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 487 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 546

Query: 564 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 623
           LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 547 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 606

Query: 624 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 683
           ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 607 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 666

Query: 684 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 743
           PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 667 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 726

Query: 744 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 803
           QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 727 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 786

Query: 804 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 863
           CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 787 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 846

Query: 864 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 923
           LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 847 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 906

Query: 924 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 978
           LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 907 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 961


>gi|56549125 dynamin 2 isoform 4 [Homo sapiens]
          Length = 866

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 340 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 399
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 400 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 459
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 460 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 519
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 520 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 576
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 577 SVEQQADSFKATRFNLE---TEWKNNYP 601
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549123 dynamin 2 isoform 2 [Homo sapiens]
          Length = 870

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 340 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 399
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 400 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 459
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 460 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 519
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 520 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 576
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 577 SVEQQADSFKATRFNLE---TEWKNNYP 601
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549121 dynamin 2 isoform 1 [Homo sapiens]
          Length = 870

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 340 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 399
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 400 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 459
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 460 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 519
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 520 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 576
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 577 SVEQQADSFKATRFNLE---TEWKNNYP 601
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549119 dynamin 2 isoform 3 [Homo sapiens]
          Length = 866

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 340 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 399
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 400 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 459
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 460 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 519
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 520 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 576
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 577 SVEQQADSFKATRFNLE---TEWKNNYP 601
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549117 dynamin 1 isoform 2 [Homo sapiens]
          Length = 851

 Score =  107 bits (267), Expect = 5e-23
 Identities = 80/265 (30%), Positives = 123/265 (46%), Gaps = 15/265 (5%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           + LI + + + D  S      N    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EDLIPLVNRLQDAFSAI--GQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 340 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 399
           +TR P+ + L       A F     +    K  D   +R EIE    +       +SP  
Sbjct: 64  VTRRPLVLQLVNATTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISPVP 119

Query: 400 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 459
           I+L V  P +  + LVDLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANS 179

Query: 460 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 519
           D   S    +  ++DP G+RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 520 VTGKG---NSSESIEAIREYEEEFF 541
           V       +  + I A    E +FF
Sbjct: 235 VNRSQKDIDGKKDITAALAAERKFF 259


>gi|59853099 dynamin 1 isoform 1 [Homo sapiens]
          Length = 864

 Score =  107 bits (267), Expect = 5e-23
 Identities = 80/265 (30%), Positives = 123/265 (46%), Gaps = 15/265 (5%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           + LI + + + D  S      N    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EDLIPLVNRLQDAFSAI--GQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 340 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 399
           +TR P+ + L       A F     +    K  D   +R EIE    +       +SP  
Sbjct: 64  VTRRPLVLQLVNATTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISPVP 119

Query: 400 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 459
           I+L V  P +  + LVDLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANS 179

Query: 460 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 519
           D   S    +  ++DP G+RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 520 VTGKG---NSSESIEAIREYEEEFF 541
           V       +  + I A    E +FF
Sbjct: 235 VNRSQKDIDGKKDITAALAAERKFF 259


>gi|171460914 dynamin 1-like isoform 1 [Homo sapiens]
          Length = 736

 Score =  104 bits (260), Expect = 4e-22
 Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           ++LI + +++ DV +   A       LP++VVVG QS+GK+SVLE +    + PRG+G +
Sbjct: 2   EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57

Query: 340 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 383
           +TR P+ + L     HV+     K +  E  +  EE             D   +R EIE 
Sbjct: 58  VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113

Query: 384 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 443
              +       VSPE I L +  P +  + LVDLPG+          D +  I  +   +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173

Query: 444 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 503
           + NPN+IIL +   + D   S    +  ++DP GRRT+ V+TK+DL +    +      +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229

Query: 504 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 542
           + G++ P+K LG   VV        N     ++IR+ E  F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270


>gi|171460918 dynamin 1-like isoform 3 [Homo sapiens]
          Length = 699

 Score =  104 bits (260), Expect = 4e-22
 Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           ++LI + +++ DV +   A       LP++VVVG QS+GK+SVLE +    + PRG+G +
Sbjct: 2   EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57

Query: 340 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 383
           +TR P+ + L     HV+     K +  E  +  EE             D   +R EIE 
Sbjct: 58  VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113

Query: 384 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 443
              +       VSPE I L +  P +  + LVDLPG+          D +  I  +   +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173

Query: 444 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 503
           + NPN+IIL +   + D   S    +  ++DP GRRT+ V+TK+DL +    +      +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229

Query: 504 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 542
           + G++ P+K LG   VV        N     ++IR+ E  F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270


>gi|171460916 dynamin 1-like isoform 2 [Homo sapiens]
          Length = 710

 Score =  104 bits (260), Expect = 4e-22
 Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           ++LI + +++ DV +   A       LP++VVVG QS+GK+SVLE +    + PRG+G +
Sbjct: 2   EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57

Query: 340 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 383
           +TR P+ + L     HV+     K +  E  +  EE             D   +R EIE 
Sbjct: 58  VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113

Query: 384 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 443
              +       VSPE I L +  P +  + LVDLPG+          D +  I  +   +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173

Query: 444 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 503
           + NPN+IIL +   + D   S    +  ++DP GRRT+ V+TK+DL +    +      +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229

Query: 504 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 542
           + G++ P+K LG   VV        N     ++IR+ E  F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270


>gi|42544243 dynamin 3 isoform a [Homo sapiens]
          Length = 863

 Score =  103 bits (257), Expect = 8e-22
 Identities = 88/328 (26%), Positives = 148/328 (45%), Gaps = 21/328 (6%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           + LI + + + D  S    S   +  LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNRLQDAFSALGQSCLLE--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 340 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 399
           +TR P+ + L       A F     +    K  D   +R EIE    +       +S   
Sbjct: 64  VTRRPLVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRLEIEAETDRVTGMNKGISSIP 119

Query: 400 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 459
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANT 179

Query: 460 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 519
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYVGV 234

Query: 520 VTGKG---NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 576
           V       +  + I+A    E +FF +    +     A ++ T +L   ++      +R+
Sbjct: 235 VNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHI---ADRMGTPHLQKVLNQQLTNHIRD 291

Query: 577 SVEQQADSFKATRFNLETE---WKNNYP 601
           ++    +  +    ++E E   +KN  P
Sbjct: 292 TLPNFRNKLQGQLLSIEHEVEAYKNFKP 319


>gi|209915561 dynamin 3 isoform b [Homo sapiens]
          Length = 859

 Score =  103 bits (257), Expect = 8e-22
 Identities = 88/328 (26%), Positives = 148/328 (45%), Gaps = 21/328 (6%)

Query: 280 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 339
           + LI + + + D  S    S   +  LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNRLQDAFSALGQSCLLE--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 340 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 399
           +TR P+ + L       A F     +    K  D   +R EIE    +       +S   
Sbjct: 64  VTRRPLVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRLEIEAETDRVTGMNKGISSIP 119

Query: 400 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 459
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANT 179

Query: 460 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 519
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYVGV 234

Query: 520 VTGKG---NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 576
           V       +  + I+A    E +FF +    +     A ++ T +L   ++      +R+
Sbjct: 235 VNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHI---ADRMGTPHLQKVLNQQLTNHIRD 291

Query: 577 SVEQQADSFKATRFNLETE---WKNNYP 601
           ++    +  +    ++E E   +KN  P
Sbjct: 292 TLPNFRNKLQGQLLSIEHEVEAYKNFKP 319


>gi|222136619 myxovirus resistance protein 1 [Homo sapiens]
          Length = 662

 Score =  102 bits (253), Expect = 2e-21
 Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)

Query: 265 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 323
           V QK+   +    L     +     +D++    A    QD  LP + V+GDQS+GK+SVL
Sbjct: 28  VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87

Query: 324 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 382
           E ++   + PRGSG ++TR P+ + L +  +      K S +++++ +  D + +  EI 
Sbjct: 88  EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144

Query: 383 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 442
                   EG  +S E I+L +    +  + L+DLPG+          D    I ++ K 
Sbjct: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204

Query: 443 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 502
           Y+Q    I L +   +VD   +    +  ++DP G RTI +LTK DL +K   +  ++  
Sbjct: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262

Query: 503 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 558
           ++   +F +K  GY  +V  +G        S+    + E+ FF+N    +  +L+  + T
Sbjct: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319

Query: 559 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 614
              L+  ++      + +S+    +  K T   +  E +     + E D NE    L +K
Sbjct: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378

Query: 615 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 670
             N    ++ +L Q      EE ++     R   H    +IEN +    + +     +  
Sbjct: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432

Query: 671 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 728
           +     Q+  ++LP       +ET+ ++  + + EP       + D ++ A  + SIK
Sbjct: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490


>gi|222136617 myxovirus resistance protein 1 [Homo sapiens]
          Length = 662

 Score =  102 bits (253), Expect = 2e-21
 Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)

Query: 265 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 323
           V QK+   +    L     +     +D++    A    QD  LP + V+GDQS+GK+SVL
Sbjct: 28  VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87

Query: 324 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 382
           E ++   + PRGSG ++TR P+ + L +  +      K S +++++ +  D + +  EI 
Sbjct: 88  EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144

Query: 383 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 442
                   EG  +S E I+L +    +  + L+DLPG+          D    I ++ K 
Sbjct: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204

Query: 443 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 502
           Y+Q    I L +   +VD   +    +  ++DP G RTI +LTK DL +K   +  ++  
Sbjct: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262

Query: 503 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 558
           ++   +F +K  GY  +V  +G        S+    + E+ FF+N    +  +L+  + T
Sbjct: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319

Query: 559 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 614
              L+  ++      + +S+    +  K T   +  E +     + E D NE    L +K
Sbjct: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378

Query: 615 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 670
             N    ++ +L Q      EE ++     R   H    +IEN +    + +     +  
Sbjct: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432

Query: 671 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 728
           +     Q+  ++LP       +ET+ ++  + + EP       + D ++ A  + SIK
Sbjct: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490


>gi|11342664 myxovirus resistance protein 2 [Homo sapiens]
          Length = 715

 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)

Query: 306 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 365
           LP + V+GDQS+GK+SVLE ++   + PRGSG ++TR P+ + L + P      + S R 
Sbjct: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175

Query: 366 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 425
            +L + +D   +  EI          G  +S E ISL +  P +  + ++DLPG+     
Sbjct: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234

Query: 426 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 485
                D    I ++ K Y+Q    I L +   +VD   +    +  ++DP G RTI +LT
Sbjct: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294

Query: 486 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 519
           K DL ++   +   +  ++    +P+K  GY  V
Sbjct: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325


>gi|110611228 utrophin [Homo sapiens]
          Length = 3433

 Score = 40.8 bits (94), Expect = 0.006
 Identities = 157/745 (21%), Positives = 297/745 (39%), Gaps = 93/745 (12%)

Query: 136  VPDIVWEIDEY-IDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLKDFFTSGHKLVSEVI 194
            V ++  ++D Y I  E++   L S+ED  +   D    VE +   KD F +    + E+ 
Sbjct: 304  VTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEV---KDQFATHEAFMMELT 360

Query: 195  GASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKI-----DQLQEELLHTQLKYQR 249
                 +   GS  +   +   +G+ SD+   ++ ++  +     + L+ E +  Q +   
Sbjct: 361  AHQSSV---GSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHD 417

Query: 250  ILERLEKENKELRKLVLQKDDKGIHHRKL------KKSLIDMYSEVLDVLSDYDASYNTQ 303
            +L  L+K+  +     L   ++ I   +        KSL  +  E   + SD +A     
Sbjct: 418  VLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKV 477

Query: 304  DHLPRVVVVGDQSAGK--TSVLEMIAQA-----RIFPRGSGEMMTR-SPVKVTLSEGPHH 355
            + L  +VV+ D+++G+  T++LE   Q          R + E   R   + +   E    
Sbjct: 478  NSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEE 537

Query: 356  VALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLV 415
              L K    E    KEE L    ++++    K+ KE  +VS   +++  +   ++R  L 
Sbjct: 538  QCLLKAWLTE----KEEAL----NKVQTSNFKDQKE-LSVSVRRLAILKEDMEMKRQTLD 588

Query: 416  DLPGVINTVTSGMAPDTKET---IFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQ 472
             L  +   V  G   D  +    I S S+   Q  ++++  ++D S    +++    +SQ
Sbjct: 589  QLSEIGQDV--GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQ 646

Query: 473  MDPHG-RRTIFV----LTKVDLAEKNVASPSRIQQI---IEGK----LFPMKALGYFAVV 520
            +       T+ V    +TK    E     P + +QI   IE K        + L +    
Sbjct: 647  IPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWIL-- 704

Query: 521  TGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQ 580
              K  ++     I+EY +   Q++  +K   LKA +   R   +  +D   +  +  VEQ
Sbjct: 705  --KWKTAIQTTEIKEYMK--MQDTSEMK-KKLKALEKEQRE-RIPRADELNQTGQILVEQ 758

Query: 581  Q------ADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQV--TPK 632
                    +  K     + +EWKN    L +L+R    ++  N    ++  L +V  T +
Sbjct: 759  MGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKE 818

Query: 633  HW------EEILQQSL------WERVSTHVI---ENIYLPAAQTMNSGTFNTTVDIKLKQ 677
             W       E  +QSL       +R  T+++     I +  A      +  +  D   + 
Sbjct: 819  EWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRG 878

Query: 678  WTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAE 737
            +       +AV+ A E  Q+     +    G  + +    LK+ + +   K       A+
Sbjct: 879  FDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENK-------AQ 931

Query: 738  DSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWK 797
             SL V+   A  ++++ +K+  D  +   + AL  +L +   A+E  V PD +K  LY +
Sbjct: 932  VSLNVLNDLAKVEKALQEKKTLDEILENQKPALH-KLAEETKALEKNVHPDVEK--LYKQ 988

Query: 798  NRTQEQCVHNETKNELEKMLKCNEE 822
                 Q   N+ K  + K L   EE
Sbjct: 989  EFDDVQGKWNKLKVLVSKDLHLLEE 1013


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 39.3 bits (90), Expect = 0.018
 Identities = 145/792 (18%), Positives = 311/792 (39%), Gaps = 129/792 (16%)

Query: 229  DKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSL---IDM 285
            DK K+ +L  +L  T  ++Q +    EK NK L       +DK +  +KL + L   +D+
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL-------EDKSLEFKKLSEELAIQLDI 1219

Query: 286  YSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPV 345
              +  + L +   +        +   +  + +        + +A +    +   +     
Sbjct: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279

Query: 346  KVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVK 405
            ++T  +   +++ F+ ++ + +  KE  + +++ +IE           ++  E  +L  +
Sbjct: 1280 QLTEEQNTLNIS-FQQATHQLE-EKENQIKSMKADIE-----------SLVTEKEALQKE 1326

Query: 406  GPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSI 465
            G   Q+                 A + +  I  + K   +N NA+ L  ++  +  ++  
Sbjct: 1327 GGNQQQA----------------ASEKESCITQLKKELSENINAVTLMKEE--LKEKKVE 1368

Query: 466  VTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGK---LFPMKALGYFAVVTG 522
            ++ L  Q+       + +   + L+EK  A  S  +Q  E K   L  ++ L  F V T 
Sbjct: 1369 ISSLSKQLTD---LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS-FKVDTL 1424

Query: 523  KGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVS---------DCFWKM 573
                  ++E + ++  +F +  K  + S    HQ T + L + +          D    +
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQ-SRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483

Query: 574  VRESVEQQADSFKATR--------------FNLETEWKNNYPRLRELDRNELFEKAKNEI 619
            ++E ++QQ   F   +               NLETE K+   R+ EL+ +   +  + E 
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIES 1543

Query: 620  LDEVI-SLSQVTPKHWEEILQ-----QSLWERVSTHVIE----------NIYLPAAQTMN 663
            L+EV+ + +Q      +E++Q     Q L E     V E           +Y   A+   
Sbjct: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1603

Query: 664  SGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVK 723
                   V++ +K    K+   KA+E   + L+ E +  + E K K    I    K+ + 
Sbjct: 1604 KKKELEHVNLSVK---SKEEELKALE---DRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657

Query: 724  EESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA-IE 782
            +   K  ++    E  L  +          +  Q+ +  ++ +EE    +LK  E++  E
Sbjct: 1658 QMEEKEEQYKKGTESHLSELN---------TKLQEREREVHILEE----KLKSVESSQSE 1704

Query: 783  NMVGPDWKKRWLYWKNRTQ---EQCV---HNETKNELEKMLKCNEEHPAYLASDEITTVR 836
             ++ P   K    +  + +   + CV   + E  + L++ L   E+    +  ++  TV 
Sbjct: 1705 TLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVS 1764

Query: 837  KNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNH----CNLCRRGFYYYQRHFVDSELEC 892
             + E R  +    LIK   H   ++H  ++ + H         + +       V+ E   
Sbjct: 1765 SHFEMR-CQYQERLIK-LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGK 1822

Query: 893  NDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQ 952
            N++     ++ +      TL+++    ++  LE+ +KE+  D     +K++      RV+
Sbjct: 1823 NNIQAKQNLENVFDDVQKTLQEKELTCQI--LEQKIKEL--DSCLVRQKEV-----HRVE 1873

Query: 953  LAEDLKKVREIQ 964
            + E   K  ++Q
Sbjct: 1874 MEELTSKYEKLQ 1885



 Score = 37.0 bits (84), Expect = 0.090
 Identities = 125/656 (19%), Positives = 251/656 (38%), Gaps = 135/656 (20%)

Query: 219  ESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK---LVLQKDDKGIHH 275
            ES KH +     EK+  L+++    Q + +++ E+ E+E + L K   ++ Q   + ++ 
Sbjct: 617  ESLKHQQDALWTEKLQVLKQQY---QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNE 673

Query: 276  RKLKK------SLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLE--MIA 327
            + L+K       L  + SE+ +VL    A +  ++ L    V+ DQ+      LE  M  
Sbjct: 674  KTLEKLDVKQTELESLSSELSEVLK---ARHKLEEELS---VLKDQTDKMKQELEAKMDE 727

Query: 328  QARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLT-KEEDLAALRHEIELR-M 385
            Q     +    ++    V +  +E        KD   + +L  KE D     H+  +  +
Sbjct: 728  QKNHHQQQVDSIIKEHEVSIQRTE-----KALKDQINQLELLLKERDKHLKEHQAHVENL 782

Query: 386  RKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQ 445
              ++K              +G   Q    +D+     + T       +E +  + +  + 
Sbjct: 783  EADIKRS------------EGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830

Query: 446  -NPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSR-IQQI 503
                 I+L  Q   V+A++    D+ +++D H  +   ++ +++     +    + + Q+
Sbjct: 831  LETERILLTKQVAEVEAQKK---DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887

Query: 504  IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 563
             E KL             G     ++ + + E E    Q    ++    K  ++ T+ LS
Sbjct: 888  YESKL-----------EDGNKEQEQTKQILVEKENMILQ----MREGQKKEIEILTQKLS 932

Query: 564  LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRN--ELFEKAKNEILD 621
                             + DS        ET++KN   ++ ++ +   E+ E  K ++LD
Sbjct: 933  A----------------KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLD 976

Query: 622  EVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDK 681
            +   L +       E+ Q+   ++ +  ++E      AQ  ++G  +    +        
Sbjct: 977  QEAKLKKELENTALELSQKE--KQFNAKMLE-----MAQANSAGISDAVSRL-------- 1021

Query: 682  QLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLR 741
                       ET Q+E    +TE   +E +D+           SI   K N  AE+ L+
Sbjct: 1022 -----------ETNQKEQIESLTEVHRRELNDVI----------SIWEKKLNQQAEE-LQ 1059

Query: 742  VIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQ 801
             I    L+++     +     + F  E  +   + T               WL      +
Sbjct: 1060 EIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEIT---------------WL-----KE 1099

Query: 802  EQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 857
            E    + T NEL++ LK    H   LA DE T ++ +LE   V+++ SL ++T+ Q
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDE-TKLKAHLEKLEVDLNKSLKENTFLQ 1154


>gi|187761324 shootin1 isoform a [Homo sapiens]
          Length = 631

 Score = 39.3 bits (90), Expect = 0.018
 Identities = 40/151 (26%), Positives = 70/151 (46%), Gaps = 27/151 (17%)

Query: 148 DFEKIRKALPSSEDLVKLAPDFDKIVESLSLLKDFFTSGHKLVSEVIGASDLLLLLGSPE 207
           ++E+++  L   +DL K A  F          ++ F   +KL  +    S LLL    P+
Sbjct: 213 EYEEMQVNLELEKDLRKKAESF---------AQEMFIEQNKLKRQ----SHLLLQSSIPD 259

Query: 208 ETAFRATDRGS--------ESDKHFRKVSDKEKIDQLQEELLHTQL-KYQRILERLEKEN 258
           +   +A D  +        E  +H +KV + E  +QL+ E LH ++   ++ LE LE++ 
Sbjct: 260 QQLLKALDENAKLTQQLEEERIQHQQKVKELE--EQLENETLHKEIHNLKQQLELLEEDK 317

Query: 259 KELRKLVLQKDDKGIHHRKLKKSLIDMYSEV 289
           KEL       ++K    R LK S+ ++   V
Sbjct: 318 KELELKYQNSEEKA---RNLKHSVDELQKRV 345


>gi|50511340 shootin1 isoform b [Homo sapiens]
          Length = 456

 Score = 39.3 bits (90), Expect = 0.018
 Identities = 40/151 (26%), Positives = 70/151 (46%), Gaps = 27/151 (17%)

Query: 148 DFEKIRKALPSSEDLVKLAPDFDKIVESLSLLKDFFTSGHKLVSEVIGASDLLLLLGSPE 207
           ++E+++  L   +DL K A  F          ++ F   +KL  +    S LLL    P+
Sbjct: 213 EYEEMQVNLELEKDLRKKAESF---------AQEMFIEQNKLKRQ----SHLLLQSSIPD 259

Query: 208 ETAFRATDRGS--------ESDKHFRKVSDKEKIDQLQEELLHTQL-KYQRILERLEKEN 258
           +   +A D  +        E  +H +KV + E  +QL+ E LH ++   ++ LE LE++ 
Sbjct: 260 QQLLKALDENAKLTQQLEEERIQHQQKVKELE--EQLENETLHKEIHNLKQQLELLEEDK 317

Query: 259 KELRKLVLQKDDKGIHHRKLKKSLIDMYSEV 289
           KEL       ++K    R LK S+ ++   V
Sbjct: 318 KELELKYQNSEEKA---RNLKHSVDELQKRV 345


>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
            sapiens]
          Length = 1591

 Score = 38.9 bits (89), Expect = 0.024
 Identities = 46/243 (18%), Positives = 97/243 (39%), Gaps = 25/243 (10%)

Query: 530  IEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATR 589
            +  +     + F+  K LK  +++        LS        +   E + QQ + ++A  
Sbjct: 1155 LNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELS-----ALERQKDEKITQQEEKYEAII 1209

Query: 590  FNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH 649
             NLE + +      +E DR +L +K   E  DE I  +    K   E++++ L E+V   
Sbjct: 1210 QNLEKD-RQKLVSSQEQDREQLIQKLNCE-KDEAIQTALKEFKLEREVVEKELLEKVKHL 1267

Query: 650  VIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEE----------- 698
              +    PA  +    + +   +++ K   +K    + +E   +   EE           
Sbjct: 1268 ENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAE 1327

Query: 699  ----FSRFMTEPKGKEHD---DIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDR 751
                F+  +T  K ++ +   D+ DKLK  ++++   +      +ED  R+++     + 
Sbjct: 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEE 1387

Query: 752  SIS 754
             +S
Sbjct: 1388 EVS 1390



 Score = 35.0 bits (79), Expect = 0.34
 Identities = 33/128 (25%), Positives = 56/128 (43%), Gaps = 4/128 (3%)

Query: 159  SEDLVKLAPDFDKIVESLSLLKD--FFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDR 216
            SED  +L  +  K+ E +S L+   F  S +   +  +  +    L G  + +A    D 
Sbjct: 1372 SEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADE 1431

Query: 217  GS-ESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHH 275
            G  +S      +S +E I  L EE     L  +R L+  E+ENK L + ++ +    +  
Sbjct: 1432 GRVDSAMETSMMSVQENIHMLSEEKQRIML-LERTLQLKEEENKRLNQRLMSQSMSSVSS 1490

Query: 276  RKLKKSLI 283
            R  +K  I
Sbjct: 1491 RHSEKIAI 1498


>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
            sapiens]
          Length = 1594

 Score = 38.9 bits (89), Expect = 0.024
 Identities = 46/243 (18%), Positives = 97/243 (39%), Gaps = 25/243 (10%)

Query: 530  IEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATR 589
            +  +     + F+  K LK  +++        LS        +   E + QQ + ++A  
Sbjct: 1155 LNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELS-----ALERQKDEKITQQEEKYEAII 1209

Query: 590  FNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH 649
             NLE + +      +E DR +L +K   E  DE I  +    K   E++++ L E+V   
Sbjct: 1210 QNLEKD-RQKLVSSQEQDREQLIQKLNCE-KDEAIQTALKEFKLEREVVEKELLEKVKHL 1267

Query: 650  VIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEE----------- 698
              +    PA  +    + +   +++ K   +K    + +E   +   EE           
Sbjct: 1268 ENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAE 1327

Query: 699  ----FSRFMTEPKGKEHD---DIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDR 751
                F+  +T  K ++ +   D+ DKLK  ++++   +      +ED  R+++     + 
Sbjct: 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEE 1387

Query: 752  SIS 754
             +S
Sbjct: 1388 EVS 1390



 Score = 35.0 bits (79), Expect = 0.34
 Identities = 33/128 (25%), Positives = 56/128 (43%), Gaps = 4/128 (3%)

Query: 159  SEDLVKLAPDFDKIVESLSLLKD--FFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDR 216
            SED  +L  +  K+ E +S L+   F  S +   +  +  +    L G  + +A    D 
Sbjct: 1372 SEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADE 1431

Query: 217  GS-ESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHH 275
            G  +S      +S +E I  L EE     L  +R L+  E+ENK L + ++ +    +  
Sbjct: 1432 GRVDSAMETSMMSVQENIHMLSEEKQRIML-LERTLQLKEEENKRLNQRLMSQSMSSVSS 1490

Query: 276  RKLKKSLI 283
            R  +K  I
Sbjct: 1491 RHSEKIAI 1498


>gi|28173564 keratin 73 [Homo sapiens]
          Length = 540

 Score = 38.5 bits (88), Expect = 0.031
 Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 3/72 (4%)

Query: 894 DVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQL 953
           D V F   Q  +  T   L QQL   ++   + N++ +LE +  +  K+++ L+G RV+L
Sbjct: 148 DKVRFLEQQNQVLETKWELLQQL---DLNNCKNNLEPILEGYISNLRKQLETLSGDRVRL 204

Query: 954 AEDLKKVREIQE 965
             +L+ VRE+ E
Sbjct: 205 DSELRSVREVVE 216


>gi|148612803 keratin 6 irs4 [Homo sapiens]
          Length = 529

 Score = 37.7 bits (86), Expect = 0.053
 Identities = 22/72 (30%), Positives = 41/72 (56%), Gaps = 3/72 (4%)

Query: 894 DVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQL 953
           D V F   Q  +  T   L QQL   ++   +KN++ +LE +  +  K+++ L+G RV+L
Sbjct: 156 DKVRFLEQQNQVLETKWELLQQL---DLNNCKKNLEPILEGYISNLRKQLETLSGDRVRL 212

Query: 954 AEDLKKVREIQE 965
             +L+ +R++ E
Sbjct: 213 DSELRSMRDLVE 224


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,010,912
Number of Sequences: 37866
Number of extensions: 1547438
Number of successful extensions: 7203
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 6864
Number of HSP's gapped (non-prelim): 455
length of query: 978
length of database: 18,247,518
effective HSP length: 112
effective length of query: 866
effective length of database: 14,006,526
effective search space: 12129651516
effective search space used: 12129651516
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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