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Search of human proteins with 224809478
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
(983 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 1883 0.0
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 1855 0.0
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 1853 0.0
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 1853 0.0
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 1853 0.0
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 1779 0.0
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 353 3e-97
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 351 2e-96
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 287 3e-77
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 273 4e-73
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 139 1e-32
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 139 1e-32
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 139 2e-32
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 131 3e-30
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 131 3e-30
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 131 3e-30
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa... 127 7e-29
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 126 1e-28
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 124 4e-28
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa... 123 7e-28
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 117 4e-26
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 117 5e-26
gi|38044112 restin isoform b [Homo sapiens] 117 7e-26
gi|4506751 restin isoform a [Homo sapiens] 117 7e-26
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 116 9e-26
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 115 2e-25
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 114 6e-25
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 113 1e-24
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 113 1e-24
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 112 2e-24
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 1884 bits (4879), Expect = 0.0
Identities = 983/983 (100%), Positives = 983/983 (100%)
Query: 1 MQPTYLPWLSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAF 60
MQPTYLPWLSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAF
Sbjct: 1 MQPTYLPWLSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAF 60
Query: 61 HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDS 120
HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDS
Sbjct: 61 HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDS 120
Query: 121 SGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD 180
SGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD
Sbjct: 121 SGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD 180
Query: 181 VNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL 240
VNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL
Sbjct: 181 VNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL 240
Query: 241 LSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITST 300
LSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITST
Sbjct: 241 LSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITST 300
Query: 301 PLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVA 360
PLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVA
Sbjct: 301 PLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVA 360
Query: 361 SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLI 420
SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLI
Sbjct: 361 SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLI 420
Query: 421 HSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISEN 480
HSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISEN
Sbjct: 421 HSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISEN 480
Query: 481 SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQ 540
SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQ
Sbjct: 481 SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQ 540
Query: 541 DLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFL 600
DLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFL
Sbjct: 541 DLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFL 600
Query: 601 FEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQA 660
FEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQA
Sbjct: 601 FEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQA 660
Query: 661 ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLK 720
ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLK
Sbjct: 661 ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLK 720
Query: 721 QLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKA 780
QLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKA
Sbjct: 721 QLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKA 780
Query: 781 AMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 840
AMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN
Sbjct: 781 AMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 840
Query: 841 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 900
IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA
Sbjct: 841 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 900
Query: 901 LNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQ 960
LNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQ
Sbjct: 901 LNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQ 960
Query: 961 MDEDVQKVLKQILTMCKNQSQKK 983
MDEDVQKVLKQILTMCKNQSQKK
Sbjct: 961 MDEDVQKVLKQILTMCKNQSQKK 983
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 1855 bits (4805), Expect = 0.0
Identities = 970/971 (99%), Positives = 970/971 (99%)
Query: 13 EKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 72
E KTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL
Sbjct: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
Query: 73 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 132
RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ
Sbjct: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
Query: 133 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 192
GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL
Sbjct: 122 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 181
Query: 193 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 252
MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT
Sbjct: 182 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 241
Query: 253 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 312
PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE
Sbjct: 242 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 301
Query: 313 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 372
PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK
Sbjct: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 361
Query: 373 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 432
LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV
Sbjct: 362 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 421
Query: 433 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 492
RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ
Sbjct: 422 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 481
Query: 493 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 552
SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN
Sbjct: 482 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 541
Query: 553 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 612
KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM
Sbjct: 542 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 601
Query: 613 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 672
KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE
Sbjct: 602 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 661
Query: 673 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 732
DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS
Sbjct: 662 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 721
Query: 733 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 792
ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY
Sbjct: 722 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 781
Query: 793 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 852
EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV
Sbjct: 782 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 841
Query: 853 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 912
NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS
Sbjct: 842 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 901
Query: 913 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 972
SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI
Sbjct: 902 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 961
Query: 973 LTMCKNQSQKK 983
LTMCKNQSQKK
Sbjct: 962 LTMCKNQSQKK 972
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1853 bits (4800), Expect = 0.0
Identities = 972/977 (99%), Positives = 973/977 (99%), Gaps = 2/977 (0%)
Query: 9 LSAKEKK--TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 66
L AK +K TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK
Sbjct: 4 LKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 63
Query: 67 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 126
GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL
Sbjct: 64 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 123
Query: 127 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 186
HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK
Sbjct: 124 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 183
Query: 187 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 246
SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ
Sbjct: 184 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 243
Query: 247 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE 306
DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE
Sbjct: 244 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE 303
Query: 307 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 366
SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN
Sbjct: 304 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 363
Query: 367 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 426
KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS
Sbjct: 364 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 423
Query: 427 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 486
TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ
Sbjct: 424 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 483
Query: 487 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 546
KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL
Sbjct: 484 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 543
Query: 547 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 606
EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE
Sbjct: 544 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 603
Query: 607 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 666
AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR
Sbjct: 604 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 663
Query: 667 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 726
KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ
Sbjct: 664 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 723
Query: 727 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 786
KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM
Sbjct: 724 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 783
Query: 787 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 846
VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK
Sbjct: 784 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 843
Query: 847 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 906
SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ
Sbjct: 844 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 903
Query: 907 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 966
LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ
Sbjct: 904 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 963
Query: 967 KVLKQILTMCKNQSQKK 983
KVLKQILTMCKNQSQKK
Sbjct: 964 KVLKQILTMCKNQSQKK 980
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1853 bits (4800), Expect = 0.0
Identities = 972/977 (99%), Positives = 973/977 (99%), Gaps = 2/977 (0%)
Query: 9 LSAKEKK--TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 66
L AK +K TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK
Sbjct: 4 LKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 63
Query: 67 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 126
GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL
Sbjct: 64 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 123
Query: 127 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 186
HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK
Sbjct: 124 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 183
Query: 187 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 246
SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ
Sbjct: 184 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 243
Query: 247 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE 306
DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE
Sbjct: 244 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE 303
Query: 307 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 366
SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN
Sbjct: 304 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 363
Query: 367 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 426
KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS
Sbjct: 364 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 423
Query: 427 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 486
TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ
Sbjct: 424 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 483
Query: 487 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 546
KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL
Sbjct: 484 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 543
Query: 547 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 606
EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE
Sbjct: 544 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 603
Query: 607 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 666
AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR
Sbjct: 604 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 663
Query: 667 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 726
KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ
Sbjct: 664 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 723
Query: 727 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 786
KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM
Sbjct: 724 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 783
Query: 787 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 846
VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK
Sbjct: 784 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 843
Query: 847 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 906
SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ
Sbjct: 844 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 903
Query: 907 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 966
LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ
Sbjct: 904 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 963
Query: 967 KVLKQILTMCKNQSQKK 983
KVLKQILTMCKNQSQKK
Sbjct: 964 KVLKQILTMCKNQSQKK 980
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1853 bits (4800), Expect = 0.0
Identities = 972/977 (99%), Positives = 973/977 (99%), Gaps = 2/977 (0%)
Query: 9 LSAKEKK--TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 66
L AK +K TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK
Sbjct: 4 LKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 63
Query: 67 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 126
GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL
Sbjct: 64 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 123
Query: 127 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 186
HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK
Sbjct: 124 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 183
Query: 187 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 246
SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ
Sbjct: 184 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 243
Query: 247 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE 306
DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE
Sbjct: 244 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE 303
Query: 307 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 366
SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN
Sbjct: 304 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 363
Query: 367 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 426
KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS
Sbjct: 364 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 423
Query: 427 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 486
TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ
Sbjct: 424 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 483
Query: 487 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 546
KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL
Sbjct: 484 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 543
Query: 547 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 606
EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE
Sbjct: 544 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 603
Query: 607 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 666
AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR
Sbjct: 604 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 663
Query: 667 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 726
KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ
Sbjct: 664 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 723
Query: 727 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 786
KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM
Sbjct: 724 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 783
Query: 787 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 846
VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK
Sbjct: 784 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 843
Query: 847 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 906
SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ
Sbjct: 844 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 903
Query: 907 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 966
LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ
Sbjct: 904 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 963
Query: 967 KVLKQILTMCKNQSQKK 983
KVLKQILTMCKNQSQKK
Sbjct: 964 KVLKQILTMCKNQSQKK 980
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 1779 bits (4607), Expect = 0.0
Identities = 943/977 (96%), Positives = 944/977 (96%), Gaps = 31/977 (3%)
Query: 9 LSAKEKK--TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 66
L AK +K TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK
Sbjct: 4 LKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 63
Query: 67 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 126
GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL
Sbjct: 64 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 123
Query: 127 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 186
HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK
Sbjct: 124 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 183
Query: 187 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 246
SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ
Sbjct: 184 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 243
Query: 247 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE 306
DADLKTPTKPKQ LSDVSSPRSITSTPLSGKE
Sbjct: 244 DADLKTPTKPKQ-----------------------------LSDVSSPRSITSTPLSGKE 274
Query: 307 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 366
SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN
Sbjct: 275 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 334
Query: 367 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 426
KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS
Sbjct: 335 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 394
Query: 427 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 486
TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ
Sbjct: 395 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 454
Query: 487 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 546
KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL
Sbjct: 455 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 514
Query: 547 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 606
EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE
Sbjct: 515 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 574
Query: 607 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 666
AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR
Sbjct: 575 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 634
Query: 667 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 726
KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ
Sbjct: 635 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 694
Query: 727 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 786
KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM
Sbjct: 695 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 754
Query: 787 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 846
VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK
Sbjct: 755 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 814
Query: 847 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 906
SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ
Sbjct: 815 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 874
Query: 907 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 966
LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ
Sbjct: 875 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 934
Query: 967 KVLKQILTMCKNQSQKK 983
KVLKQILTMCKNQSQKK
Sbjct: 935 KVLKQILTMCKNQSQKK 951
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 353 bits (907), Expect = 3e-97
Identities = 299/1110 (26%), Positives = 520/1110 (46%), Gaps = 174/1110 (15%)
Query: 8 WLSA--KEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAA 65
W S K + +WNK DDRL++A E GD EKV S+L KKG + K D EG++ FH+ +
Sbjct: 5 WFSCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTS 64
Query: 66 KGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTA 125
KG++ECL ++ HGVD+T DT G +ALHLAAK H C++KLLQ CP E D G+TA
Sbjct: 65 KGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTA 124
Query: 126 LHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRN 185
LH AA C ++Q+LC+H + +N KD+DG PL+LA Q IC L+D GADVNSR+
Sbjct: 125 LHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRD 184
Query: 186 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 245
K RTALML CE G +AVE LIK GAD++L+D+LG+++ +Y+++ +N I +LL
Sbjct: 185 KQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL----- 239
Query: 246 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 305
K +SE + ++ P + L+ + ++ S +
Sbjct: 240 ------------------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQ 281
Query: 306 --ESVFFAEPPFKAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQA 357
+ + K + I++ + L D G + ++ E++++ L SLL A
Sbjct: 282 NIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAA 341
Query: 358 KVASLTLHNKELQDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-S 414
K H + L+ K+ K E+D L S+ S + + L K G+ DS+ +
Sbjct: 342 KEKQ---HEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCT 396
Query: 415 SPSVLIH------------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVEL 462
SP + H SL T+ ++ I L++ L+ ++ ES++ +R +LQ EL
Sbjct: 397 SPGIPAHMQSRSMLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNEL 454
Query: 463 QSRRAE--LVCLNNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGL 513
+ AE + L + E+S + L LK+ Q + E+ +V +Q +K L
Sbjct: 455 AHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHL 514
Query: 514 VSPESMDNYSHFHELRVTEEEINV------------------------------------ 537
S + N+ EL+ +++ V
Sbjct: 515 TSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEE 574
Query: 538 ---LKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMN 594
L+++L E E+ KV E+E + E + P E++E MKSS + +
Sbjct: 575 NKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKA 634
Query: 595 KEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSE 650
K+ + +++++ EI +LK + +K+++ Q +E E +K + + EL K+++E
Sbjct: 635 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITE 694
Query: 651 LSQLYKEAQAELED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVS 694
L+ + Q E+E Y K L++ +T E Y+ K H+ ++ N
Sbjct: 695 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
Query: 695 RAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKI 754
+E K + K+L E L + V + V +H + I L++ E+++++
Sbjct: 755 LLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQL 814
Query: 755 SNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESV 814
S LK+ + ++ L + K M++ VP ++E+++ +L ++ +L +
Sbjct: 815 SELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVK 874
Query: 815 KEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS--------------------KEQEVN- 853
K+ E ++ E V+I+ + +KR EN Q +K+ K Q+ N
Sbjct: 875 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNA 934
Query: 854 ELLQKFQQAQEEL----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTK 896
E+L +++ QEE+ AE+K + ++ E+ ++K KE
Sbjct: 935 EILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE--- 991
Query: 897 LKEALNSLSQ-LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLY 955
LK+ L+ +Q S S K+ Q+ + L++++ LQ L + + + + + H +
Sbjct: 992 LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEME 1045
Query: 956 AVQGQMDEDVQKVLK---QILTMCKNQSQK 982
+ +++ K LK Q T KN +K
Sbjct: 1046 RALSRKTDELNKQLKDLSQKYTEVKNVKEK 1075
Score = 232 bits (591), Expect = 1e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 226 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 285
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 644 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 694
Query: 286 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 339
L + + + I L K E K ++ ++D D L
Sbjct: 695 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
Query: 340 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 395
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 755 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 808
Query: 396 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 455
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 809 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 856
Query: 456 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 515
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 857 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 911
Query: 516 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 571
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 912 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 964
Query: 572 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 622
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 965 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1024
Query: 623 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 670
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
Query: 671 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 724
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1144
Query: 725 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 782
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1204
Query: 783 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 840
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 1205 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1264
Query: 841 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 900
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 1265 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1321
Query: 901 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 959
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 1322 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1381
Query: 960 QMDEDVQKVLKQILTM 975
MDEDVQ+ L QI+ M
Sbjct: 1382 HMDEDVQEALLQIIQM 1397
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 351 bits (901), Expect = 2e-96
Identities = 296/1098 (26%), Positives = 516/1098 (46%), Gaps = 172/1098 (15%)
Query: 18 EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 77
+WNK DDRL++A E GD EKV S+L KKG + K D EG++ FH+ +KG++ECL ++
Sbjct: 30 DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI 89
Query: 78 HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 137
HGVD+T DT G +ALHLAAK H C++KLLQ CP E D G+TALH AA C +
Sbjct: 90 HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSS 149
Query: 138 VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 197
+Q+LC+H + +N KD+DG PL+LA Q IC L+D GADVNSR+K RTALML CE
Sbjct: 150 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCE 209
Query: 198 IGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPK 257
G +AVE LIK GAD++L+D+LG+++ +Y+++ +N I +LL
Sbjct: 210 YGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL----------------- 252
Query: 258 QHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK--ESVFFAEPPF 315
K +SE + ++ P + L+ + ++ S + + +
Sbjct: 253 ------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDL 306
Query: 316 KAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLTLHNKEL 369
K + I++ + L D G + ++ E++++ L SLL AK H + L
Sbjct: 307 KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ---HEESL 363
Query: 370 QDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH----- 421
+ K+ K E+D L S+ S + + L K G+ DS+ +SP + H
Sbjct: 364 RTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPAHMQSRS 421
Query: 422 -------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE--LVCL 472
SL T+ ++ I L++ L+ ++ ES++ +R +LQ EL + AE + L
Sbjct: 422 MLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAL 479
Query: 473 NNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESMDNYSHF 525
+ E+S + L LK+ Q + E+ +V +Q +K L S + N+
Sbjct: 480 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 539
Query: 526 HELRVTEEEINV---------------------------------------LKQDLQNAL 546
EL+ +++ V L+++L
Sbjct: 540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
Query: 547 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 606
E E+ KV E+E + E + P E++E MKSS + + K+ + ++++
Sbjct: 600 MEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEK 659
Query: 607 AQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL 662
+ EI +LK + +K+++ Q +E E +K + + EL K+++EL+ + Q E+
Sbjct: 660 SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI 719
Query: 663 ED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAEDALSEMK 706
E Y K L++ +T E Y+ K H+ ++ N +E K
Sbjct: 720 EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKK 779
Query: 707 SQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEV 766
+ K+L E L + V + V +H + I L++ E+++++S LK+ +
Sbjct: 780 LEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 839
Query: 767 EVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQ 826
++ L + K M++ VP ++E+++ +L ++ +L + K+ E ++ E V+
Sbjct: 840 KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVK 899
Query: 827 IRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKFQQAQEE 865
I+ + +KR EN Q +K+ K Q+ N E+L +++ QEE
Sbjct: 900 IKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEE 959
Query: 866 L----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALNSLSQ-L 907
+ AE+K + ++ E+ ++K KE LK+ L+ +Q
Sbjct: 960 IVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLSEQTQKY 1016
Query: 908 SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQK 967
S S K+ Q+ + L++++ LQ L + + + + + H + + +++ K
Sbjct: 1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRKTDELNK 1070
Query: 968 VLK---QILTMCKNQSQK 982
LK Q T KN +K
Sbjct: 1071 QLKDLSQKYTEVKNVKEK 1088
Score = 232 bits (591), Expect = 1e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 226 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 285
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 657 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 707
Query: 286 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 339
L + + + I L K E K ++ ++D D L
Sbjct: 708 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 767
Query: 340 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 395
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 768 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 821
Query: 396 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 455
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 822 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 869
Query: 456 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 515
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 870 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 924
Query: 516 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 571
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 925 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 977
Query: 572 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 622
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 978 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1037
Query: 623 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 670
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 1038 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
Query: 671 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 724
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1157
Query: 725 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 782
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1217
Query: 783 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 840
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 1218 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1277
Query: 841 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 900
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 1278 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1334
Query: 901 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 959
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 1335 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1394
Query: 960 QMDEDVQKVLKQILTM 975
MDEDVQ+ L QI+ M
Sbjct: 1395 HMDEDVQEALLQIIQM 1410
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 287 bits (735), Expect = 3e-77
Identities = 274/1046 (26%), Positives = 465/1046 (44%), Gaps = 103/1046 (9%)
Query: 3 PTYLPWLSAK-EKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFH 61
P +P +A+ +++ +W K+D+RLLQAVEN DA +VA+L+ +KG TK D EGK+AFH
Sbjct: 28 PCPIPKPAARGRRQSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFH 87
Query: 62 LAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 121
LAA +G CL VMI HG +V + D G++ALHLAAK H +C+++LLQ+ C + VDSS
Sbjct: 88 LAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSS 147
Query: 122 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 181
G TALH+AAA GCL ++LC K+ +N +D G PL++A Q H+++C LL GA
Sbjct: 148 GWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAA 207
Query: 182 NSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 241
N ++ GRTALMLACE S VE L++ GA + D+LG +A HY L+ + L+L
Sbjct: 208 NDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGD----KLIL 263
Query: 242 SKISQDADLKTPTKPKQHDQVSKISSERS-------GTPKKRKAPPPPISPTQLSDVSSP 294
+ + A +P D + SS+ S G PKKRKAPPPP S D +
Sbjct: 264 HLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAY 323
Query: 295 RSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ-QDLLS 353
I + +I + ++K+R + A SL + + + Q LL
Sbjct: 324 EEIVRLRQERGRLL--------QKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLV 375
Query: 354 LLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 413
Q + SL + LQ +L S E E + + + Q + G PG +
Sbjct: 376 ERQEEKESLGREVESLQSRL---SLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQ 432
Query: 414 SSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLN 473
SPS H L V +Q QE+++ +Q LE+ E + Q++VE + L +
Sbjct: 433 LSPSAQEH-LASLQEQVAVLTRQNQELMEKVQ-ILENFEKDETQMEVEALAEVIPLALYD 490
Query: 474 N-----TEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL 528
+ ++ ++ Q L++ +++ E +E + + G + ++ + +
Sbjct: 491 SLRAEFDQLRRQHAEALQALRQQETR-EVPREEGAACGESEVAGATATKNGPTHMELNGS 549
Query: 529 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVER-------EKGTVIKPPVEEYEE 581
E ++N + + E + + E E E K T KP E E
Sbjct: 550 VAPETKVNG-AETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVRE 608
Query: 582 MKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK--DTLKSQMTQEASDEAE-------- 631
M+++ +E+A + K AQ + + + + T+ ++EAE
Sbjct: 609 METT---------EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
Query: 632 -----------DMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIH 680
+M+ +R + VS +A + L AE
Sbjct: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASE 719
Query: 681 KAEHE---KLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSIT--- 734
K + E ++ L R + +A +E+++ K + +L + +E S
Sbjct: 720 KLQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGG 779
Query: 735 ---EHLQVITTLRTAAKEMEEKISNLKE-HLASKEVEVAKLEKQLLEEKAAMTDAMVPRS 790
+ Q+ L A +++ ++ S L+E AS ++ A+ + L EE+A A + +
Sbjct: 780 GGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQR 839
Query: 791 SYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQ 850
+L+ S E EV L+E + + +E+ + + E L + +
Sbjct: 840 EEARLEQSRELEV------LREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACE 893
Query: 851 EVNELLQKFQQAQEELAEMKRYAESSSKLEEDK----------DKKINEMSKEVTKLKEA 900
E + L + ++A E L + A +L+E+ ++++ KE +L+
Sbjct: 894 EARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAE 953
Query: 901 LNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQ----EVISVYRMHLLYA 956
L S + S +R + LQ V QL+ QL E ++H+ EV V R L
Sbjct: 954 LERERVCSVALSEHER---IVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMK 1010
Query: 957 VQGQMDEDVQKVLKQILTMCKNQSQK 982
+ E +Q L + ++++
Sbjct: 1011 SERHAAEAQLATAEQQLRGLRTEAER 1036
Score = 157 bits (397), Expect = 5e-38
Identities = 131/454 (28%), Positives = 222/454 (48%), Gaps = 39/454 (8%)
Query: 534 EINVLKQDLQNALEESERNKEKVRELEEKL-----VEREKGTVIKPPVEEYEEMKSSYCS 588
E+ + L+ AL + ER E ELE L E E G ++ V E E +S
Sbjct: 724 ELETRIRGLEEALRQRER--EAAAELEAALGKCEAAEAEAGR-LRERVREAEGSGASGGG 780
Query: 589 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQ 647
+ A ++A+E++ L+ A DEA + L +
Sbjct: 781 GGDTTQLRAAL-----EQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
Query: 648 VSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKS 707
+++ + E ELE R++ + T E A E +R AE ++E+ +
Sbjct: 836 LAQREEARLEQSRELEVLREQLATARATGEQQRTAAAE-----LGRARDAAEARVAELPA 890
Query: 708 QYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE 767
+ L +L++ +A +++ V +EH + L+ A E+ + ++L++ + + E
Sbjct: 891 ACEEARQGLAELREASEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGKE 946
Query: 768 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 827
A+L +L E+ V S +E++ +L++ V+ L +L+E + EK +EV Q+
Sbjct: 947 AARLRAELERERVCS----VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
Query: 828 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 887
+ E +K E+ + L + EQ++ L + ++A++ R E+ K +E KDKKI
Sbjct: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA---QSRAQEALDKAKE-KDKKI 1058
Query: 888 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 947
E+SKEV LKEAL + + ++EAL+ QVK LQ QL E + H V++
Sbjct: 1059 TELSKEVFNLKEALKE--------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
Query: 948 VYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 981
+YR HLLYA+QGQMDEDVQ++L QIL M + Q+Q
Sbjct: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
Score = 30.8 bits (68), Expect = 6.5
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 12/133 (9%)
Query: 434 IQQLQEILQDLQKRLESSEAERKQLQVE---LQSRR--AELVCLNNTEISENSSDLSQKL 488
+ QL+ L++L +R E + AE Q+Q E ++S R AE + +++
Sbjct: 978 VAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA 1037
Query: 489 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE--LRVTEEEINVLK---QDLQ 543
++ QS+ +EA+ + + +K K+ +S E + E + E+ L+ +DLQ
Sbjct: 1038 RQAQSRAQEALDK--AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ 1095
Query: 544 NALEESERNKEKV 556
L+E+ R+ V
Sbjct: 1096 QQLQEAARDHSSV 1108
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 273 bits (699), Expect = 4e-73
Identities = 255/1036 (24%), Positives = 465/1036 (44%), Gaps = 115/1036 (11%)
Query: 10 SAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHV 69
S+ + WN++D +LL+AV GD +VA+L +K A TK DS G++ FHLAA+KG
Sbjct: 8 SSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLT 67
Query: 70 ECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYA 129
ECL +++ +G D+ +++ G +ALHLA + +C++ LLQ ++VD+ ++ LH+A
Sbjct: 68 ECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWA 127
Query: 130 AAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGR 189
A+ GC +V +LC+H++ +++ D DG PL++A GH+ IC LL GA VN +K+ +
Sbjct: 128 ASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDK 187
Query: 190 TALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDAD 249
+AL+LACE GS+ E L+ GAD VDS G++ALHY+ +++ + L +S+
Sbjct: 188 SALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRR- 246
Query: 250 LKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVF 309
+ + QH ++ +S P + +A PP S + +E +
Sbjct: 247 -RGGQRLVQHPDLASQAS-----PSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRW 300
Query: 310 FAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ--QDLLSLLQAKVASLTLHNK 367
E + + +E + + T A + LD+ ++ + Q+L LL + +
Sbjct: 301 KYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGS 360
Query: 368 ELQ---DKLQAKSPKE--AEADLSFDSYHSTQTDLGPSL--------------------G 402
L+ D ++ PK+ AE+ + P L
Sbjct: 361 SLRPGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRS 420
Query: 403 KPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ-LQVE 461
+P E PP S +S ++ + T + Q D +L + + E Q L VE
Sbjct: 421 QPEEQGPPQSPASETI------RKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVE 474
Query: 462 LQSRRAELV--CLNNTEISENSSDLSQKLKETQS-------------------------- 493
AE V N + + +L+ +E +
Sbjct: 475 PGGTVAEPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAW 534
Query: 494 -KYEEAMKEVLSVQKQMKLGL-VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESER 551
K E ++ VL+ + K GL V PE S L+ I KQD EE E+
Sbjct: 535 EKMEARLERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSI---KQD-----EEKEK 586
Query: 552 NKEKVR--ELEEKLVEREKGTVIKPPVE-EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQ 608
R L E+ G + K +E E ++ S +++E + + L + Q Q
Sbjct: 587 RVPGARGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGE----LGRERQRLQ 642
Query: 609 EEIMKLKDTLKSQMT--QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 666
E+ L L+ + EA + + +++++ + +EL + +L K ++ R
Sbjct: 643 RELQSLSQRLQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLR 702
Query: 667 KRKSL--EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVD 724
D+ E +++ + ++ + D E + +++ E QL+ +
Sbjct: 703 GLWDCLPADLVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLS 762
Query: 725 AQKENSVSITEHLQ-VITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLE--EKAA 781
+E S+ + L ++EE++ ++ ++ K E+ KL++ L + E+ A
Sbjct: 763 PCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVA 822
Query: 782 MTDAMVPRS--SYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKE 839
A S +EK + SL ++ +LK +++ EV ++R V++ +R
Sbjct: 823 ELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSG 882
Query: 840 NIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKE 899
++ ++ EQE +QA E +++ +++ L+E + I + K+KE
Sbjct: 883 DLAA--QAAEQE--------RQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKE 932
Query: 900 ALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 959
L L QL S+++ A++ + +L QL + +K H+E+IS YR HLL A +G
Sbjct: 933 LLKKLEQL----------SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARG 982
Query: 960 QMDEDVQKVLKQILTM 975
M+ +V +L QIL+M
Sbjct: 983 YMEHEVYNILLQILSM 998
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 139 bits (350), Expect = 1e-32
Identities = 205/941 (21%), Positives = 384/941 (40%), Gaps = 116/941 (12%)
Query: 25 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 136 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINI 195
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
D + L A C LL+ D G TALHYA + L H
Sbjct: 196 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 255
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 256 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 315
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS-----------KISQDADLKTP 253
L+++ ++ D G A Y+ + IQ +L +Q+ P
Sbjct: 316 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 375
Query: 254 TKPKQHDQVSKISSERSGTPKK---RKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFF 310
K+ + K+ + G + + A + S+ P+ S K+ F
Sbjct: 376 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQD--SQSYGKKKDEMF 433
Query: 311 AEPPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA 360
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 434 GNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVA 493
Query: 361 -------SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 413
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 494 QYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERK 548
Query: 414 SSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCL 472
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 549 DLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---AL 605
Query: 473 NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELR 529
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 606 REKTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIR 655
Query: 530 VTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSV 589
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 656 QRELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY--- 708
Query: 590 IENMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDEL 644
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 709 --NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDET 763
Query: 645 NKQVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT- 691
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 764 WTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTI 823
Query: 692 -----------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSI 733
N + K + ++K ++ ++ E + + V+ K+N V
Sbjct: 824 NMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLH 883
Query: 734 TEHLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDA 785
E L + L K +EEK+ NLK H+ VE+ K++ K L+E+A
Sbjct: 884 QELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIE 943
Query: 786 MVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLL 845
+ +K Q+ E ++ L S+K+KE +V + S++K E++ T L
Sbjct: 944 KLEEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTEL 999
Query: 846 KSKEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 885
+ ++ L+ E++ + K+ A S+KL +K++
Sbjct: 1000 EEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1040
Score = 56.2 bits (134), Expect = 1e-07
Identities = 114/579 (19%), Positives = 237/579 (40%), Gaps = 95/579 (16%)
Query: 442 QDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK-------ETQSK 494
++ Q+RLE SE ++ Q ++ E+ N + + + L ++L + K
Sbjct: 405 EEKQERLERSENKQPQDSQSYGKKKDEM--FGNFMLKRDIAMLKEELYAIKNDSLRKEKK 462
Query: 495 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD---LQNALEESER 551
Y + +K + + + + E M ++ +++N LK + L + LE+ +
Sbjct: 463 YIQEIKSITEINANFEKSVRLNEEMIT----KKVAQYSQQLNDLKAENARLNSKLEKEKH 518
Query: 552 NKEKVRELEEKLVEREKGTVIKPPVEEYEEM-----------KSSYCSVIENMNKEKAFL 600
NKE++ E L + + EY E+ ++ S E M + L
Sbjct: 519 NKERLEAEVESLHSN-----LATAINEYNEILERKDLELVLWRADDVSRHETMGSNISQL 573
Query: 601 FEKYQEAQEEIMKLK---DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLY 655
+K + E++ K + +TLK ++ T++A E E++ + + ++ E+ Q++
Sbjct: 574 TDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMH 633
Query: 656 -----KEAQA--------------ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA 696
KE+Q+ ELE+ + LED E +K + N+ R
Sbjct: 634 PNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEI------VINIHRD 687
Query: 697 KAEDALSEMKSQYSK-VLNELTQLKQ-LVDAQKENSV----------SITEHLQVITTLR 744
E+ ++ + +K ++NE LK+ L+ +KE + + +HL+ +
Sbjct: 688 CLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSE 747
Query: 745 TAAKEMEEKISNLKEHLASK----EVEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSS 798
+ + NL E SK +VE+ EK K +++ ++ + K
Sbjct: 748 SPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRE 807
Query: 799 LESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQ--------VKREKENIQTLLKSKEQ 850
LE E + L+ ++ +E +++ K+ K+ L+ KE
Sbjct: 808 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEA 867
Query: 851 EVNE---LLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 907
++ L + + +EL M + E KLE+DK ++ T +++ + L ++
Sbjct: 868 VSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKV 927
Query: 908 -SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 945
Y + +R Q +E L++ Q Q AE +KQ +++
Sbjct: 928 QEYKSELDERAMQAIEKLEEIHLQKQ---AEYEKQLEQL 963
Score = 44.3 bits (103), Expect = 6e-04
Identities = 72/433 (16%), Positives = 176/433 (40%), Gaps = 61/433 (14%)
Query: 532 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 591
++ I++ QD+ E +R ++++++E + + + +E + ++
Sbjct: 320 QQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLK 379
Query: 592 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS-- 649
K K K E +K+ K + + + ++ ++ + DE+
Sbjct: 380 KRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLK 439
Query: 650 -ELSQLYKEAQAELEDY--RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMK 706
+++ L +E A D +++K ++++ + A EK ++L E+ +++
Sbjct: 440 RDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLN-------EEMITKKV 492
Query: 707 SQYSKVLNEL----TQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 762
+QYS+ LN+L +L ++ +K N + +E ++ +L +LA
Sbjct: 493 AQYSQQLNDLKAENARLNSKLEKEKHNK-----------------ERLEAEVESLHSNLA 535
Query: 763 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 822
+ E ++LE K + ++ R+ ++ S +S L K E +
Sbjct: 536 TAINEY----NEILERKDL--ELVLWRADDVSRHETMGSNISQLTDK-------NELLTE 582
Query: 823 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 882
+V + R + + +K + + L+ K + + +QAQ + EMK+ + E
Sbjct: 583 QVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQ 642
Query: 883 KDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------------EALQQQV 928
K N S+E + +E N L + + + ++++ + L+++
Sbjct: 643 SIGKQNS-SEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 701
Query: 929 KQLQNQLAECKKQ 941
K+L N+ K++
Sbjct: 702 KELMNEYNYLKEK 714
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 139 bits (350), Expect = 1e-32
Identities = 205/941 (21%), Positives = 384/941 (40%), Gaps = 116/941 (12%)
Query: 25 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 165 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINI 224
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
D + L A C LL+ D G TALHYA + L H
Sbjct: 225 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 284
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 285 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 344
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS-----------KISQDADLKTP 253
L+++ ++ D G A Y+ + IQ +L +Q+ P
Sbjct: 345 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 404
Query: 254 TKPKQHDQVSKISSERSGTPKK---RKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFF 310
K+ + K+ + G + + A + S+ P+ S K+ F
Sbjct: 405 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQD--SQSYGKKKDEMF 462
Query: 311 AEPPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA 360
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 463 GNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVA 522
Query: 361 -------SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 413
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 523 QYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERK 577
Query: 414 SSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCL 472
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 578 DLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---AL 634
Query: 473 NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELR 529
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 635 REKTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIR 684
Query: 530 VTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSV 589
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 685 QRELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY--- 737
Query: 590 IENMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDEL 644
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 738 --NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDET 792
Query: 645 NKQVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT- 691
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 793 WTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTI 852
Query: 692 -----------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSI 733
N + K + ++K ++ ++ E + + V+ K+N V
Sbjct: 853 NMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLH 912
Query: 734 TEHLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDA 785
E L + L K +EEK+ NLK H+ VE+ K++ K L+E+A
Sbjct: 913 QELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIE 972
Query: 786 MVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLL 845
+ +K Q+ E ++ L S+K+KE +V + S++K E++ T L
Sbjct: 973 KLEEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTEL 1028
Query: 846 KSKEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 885
+ ++ L+ E++ + K+ A S+KL +K++
Sbjct: 1029 EEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1069
Score = 56.2 bits (134), Expect = 1e-07
Identities = 114/579 (19%), Positives = 237/579 (40%), Gaps = 95/579 (16%)
Query: 442 QDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK-------ETQSK 494
++ Q+RLE SE ++ Q ++ E+ N + + + L ++L + K
Sbjct: 434 EEKQERLERSENKQPQDSQSYGKKKDEM--FGNFMLKRDIAMLKEELYAIKNDSLRKEKK 491
Query: 495 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD---LQNALEESER 551
Y + +K + + + + E M ++ +++N LK + L + LE+ +
Sbjct: 492 YIQEIKSITEINANFEKSVRLNEEMIT----KKVAQYSQQLNDLKAENARLNSKLEKEKH 547
Query: 552 NKEKVRELEEKLVEREKGTVIKPPVEEYEEM-----------KSSYCSVIENMNKEKAFL 600
NKE++ E L + + EY E+ ++ S E M + L
Sbjct: 548 NKERLEAEVESLHSN-----LATAINEYNEILERKDLELVLWRADDVSRHETMGSNISQL 602
Query: 601 FEKYQEAQEEIMKLK---DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLY 655
+K + E++ K + +TLK ++ T++A E E++ + + ++ E+ Q++
Sbjct: 603 TDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMH 662
Query: 656 -----KEAQA--------------ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA 696
KE+Q+ ELE+ + LED E +K + N+ R
Sbjct: 663 PNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEI------VINIHRD 716
Query: 697 KAEDALSEMKSQYSK-VLNELTQLKQ-LVDAQKENSV----------SITEHLQVITTLR 744
E+ ++ + +K ++NE LK+ L+ +KE + + +HL+ +
Sbjct: 717 CLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSE 776
Query: 745 TAAKEMEEKISNLKEHLASK----EVEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSS 798
+ + NL E SK +VE+ EK K +++ ++ + K
Sbjct: 777 SPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRE 836
Query: 799 LESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQ--------VKREKENIQTLLKSKEQ 850
LE E + L+ ++ +E +++ K+ K+ L+ KE
Sbjct: 837 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEA 896
Query: 851 EVNE---LLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 907
++ L + + +EL M + E KLE+DK ++ T +++ + L ++
Sbjct: 897 VSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKV 956
Query: 908 -SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 945
Y + +R Q +E L++ Q Q AE +KQ +++
Sbjct: 957 QEYKSELDERAMQAIEKLEEIHLQKQ---AEYEKQLEQL 992
Score = 44.3 bits (103), Expect = 6e-04
Identities = 72/433 (16%), Positives = 176/433 (40%), Gaps = 61/433 (14%)
Query: 532 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 591
++ I++ QD+ E +R ++++++E + + + +E + ++
Sbjct: 349 QQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLK 408
Query: 592 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS-- 649
K K K E +K+ K + + + ++ ++ + DE+
Sbjct: 409 KRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLK 468
Query: 650 -ELSQLYKEAQAELEDY--RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMK 706
+++ L +E A D +++K ++++ + A EK ++L E+ +++
Sbjct: 469 RDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLN-------EEMITKKV 521
Query: 707 SQYSKVLNEL----TQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 762
+QYS+ LN+L +L ++ +K N + +E ++ +L +LA
Sbjct: 522 AQYSQQLNDLKAENARLNSKLEKEKHNK-----------------ERLEAEVESLHSNLA 564
Query: 763 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 822
+ E ++LE K + ++ R+ ++ S +S L K E +
Sbjct: 565 TAINEY----NEILERKDL--ELVLWRADDVSRHETMGSNISQLTDK-------NELLTE 611
Query: 823 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 882
+V + R + + +K + + L+ K + + +QAQ + EMK+ + E
Sbjct: 612 QVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQ 671
Query: 883 KDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------------EALQQQV 928
K N S+E + +E N L + + + ++++ + L+++
Sbjct: 672 SIGKQNS-SEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 730
Query: 929 KQLQNQLAECKKQ 941
K+L N+ K++
Sbjct: 731 KELMNEYNYLKEK 743
>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1139
Score = 139 bits (349), Expect = 2e-32
Identities = 205/941 (21%), Positives = 384/941 (40%), Gaps = 116/941 (12%)
Query: 25 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 165 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDRKDRTVLHLACAHGRVQVVTLLLDRKCQINI 224
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
D + L A C LL+ D G TALHYA + L H
Sbjct: 225 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 284
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 285 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 344
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS-----------KISQDADLKTP 253
L+++ ++ D G A Y+ + IQ +L +Q+ P
Sbjct: 345 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 404
Query: 254 TKPKQHDQVSKISSERSGTPKK---RKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFF 310
K+ + K+ + G + + A + S+ P+ S K+ F
Sbjct: 405 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQD--SQSYGKKKDEMF 462
Query: 311 AEPPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA 360
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 463 GNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVA 522
Query: 361 -------SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 413
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 523 QYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERK 577
Query: 414 SSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCL 472
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 578 DLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---AL 634
Query: 473 NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELR 529
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 635 REKTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIR 684
Query: 530 VTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSV 589
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 685 QRELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY--- 737
Query: 590 IENMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDEL 644
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 738 --NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDET 792
Query: 645 NKQVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT- 691
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 793 WTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTI 852
Query: 692 -----------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSI 733
N + K + ++K ++ ++ E + + V+ K+N V
Sbjct: 853 NMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLH 912
Query: 734 TEHLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDA 785
E L + L K +EEK+ NLK H+ VE+ K++ K L+E+A
Sbjct: 913 QELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIE 972
Query: 786 MVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLL 845
+ +K Q+ E ++ L S+K+KE +V + S++K E++ T L
Sbjct: 973 KLEEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTEL 1028
Query: 846 KSKEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 885
+ ++ L+ E++ + K+ A S+KL +K++
Sbjct: 1029 EEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1069
Score = 56.2 bits (134), Expect = 1e-07
Identities = 114/579 (19%), Positives = 237/579 (40%), Gaps = 95/579 (16%)
Query: 442 QDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK-------ETQSK 494
++ Q+RLE SE ++ Q ++ E+ N + + + L ++L + K
Sbjct: 434 EEKQERLERSENKQPQDSQSYGKKKDEM--FGNFMLKRDIAMLKEELYAIKNDSLRKEKK 491
Query: 495 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD---LQNALEESER 551
Y + +K + + + + E M ++ +++N LK + L + LE+ +
Sbjct: 492 YIQEIKSITEINANFEKSVRLNEEMIT----KKVAQYSQQLNDLKAENARLNSKLEKEKH 547
Query: 552 NKEKVRELEEKLVEREKGTVIKPPVEEYEEM-----------KSSYCSVIENMNKEKAFL 600
NKE++ E L + + EY E+ ++ S E M + L
Sbjct: 548 NKERLEAEVESLHSN-----LATAINEYNEILERKDLELVLWRADDVSRHETMGSNISQL 602
Query: 601 FEKYQEAQEEIMKLK---DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLY 655
+K + E++ K + +TLK ++ T++A E E++ + + ++ E+ Q++
Sbjct: 603 TDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMH 662
Query: 656 -----KEAQA--------------ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA 696
KE+Q+ ELE+ + LED E +K + N+ R
Sbjct: 663 PNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEI------VINIHRD 716
Query: 697 KAEDALSEMKSQYSK-VLNELTQLKQ-LVDAQKENSV----------SITEHLQVITTLR 744
E+ ++ + +K ++NE LK+ L+ +KE + + +HL+ +
Sbjct: 717 CLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSE 776
Query: 745 TAAKEMEEKISNLKEHLASK----EVEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSS 798
+ + NL E SK +VE+ EK K +++ ++ + K
Sbjct: 777 SPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRE 836
Query: 799 LESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQ--------VKREKENIQTLLKSKEQ 850
LE E + L+ ++ +E +++ K+ K+ L+ KE
Sbjct: 837 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEA 896
Query: 851 EVNE---LLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 907
++ L + + +EL M + E KLE+DK ++ T +++ + L ++
Sbjct: 897 VSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKV 956
Query: 908 -SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 945
Y + +R Q +E L++ Q Q AE +KQ +++
Sbjct: 957 QEYKSELDERAMQAIEKLEEIHLQKQ---AEYEKQLEQL 992
Score = 44.3 bits (103), Expect = 6e-04
Identities = 72/433 (16%), Positives = 176/433 (40%), Gaps = 61/433 (14%)
Query: 532 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 591
++ I++ QD+ E +R ++++++E + + + +E + ++
Sbjct: 349 QQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLK 408
Query: 592 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS-- 649
K K K E +K+ K + + + ++ ++ + DE+
Sbjct: 409 KRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLK 468
Query: 650 -ELSQLYKEAQAELEDY--RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMK 706
+++ L +E A D +++K ++++ + A EK ++L E+ +++
Sbjct: 469 RDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLN-------EEMITKKV 521
Query: 707 SQYSKVLNEL----TQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 762
+QYS+ LN+L +L ++ +K N + +E ++ +L +LA
Sbjct: 522 AQYSQQLNDLKAENARLNSKLEKEKHNK-----------------ERLEAEVESLHSNLA 564
Query: 763 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 822
+ E ++LE K + ++ R+ ++ S +S L K E +
Sbjct: 565 TAINEY----NEILERKDL--ELVLWRADDVSRHETMGSNISQLTDK-------NELLTE 611
Query: 823 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 882
+V + R + + +K + + L+ K + + +QAQ + EMK+ + E
Sbjct: 612 QVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQ 671
Query: 883 KDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------------EALQQQV 928
K N S+E + +E N L + + + ++++ + L+++
Sbjct: 672 SIGKQNS-SEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 730
Query: 929 KQLQNQLAECKKQ 941
K+L N+ K++
Sbjct: 731 KELMNEYNYLKEK 743
>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 131 bits (330), Expect = 3e-30
Identities = 206/947 (21%), Positives = 393/947 (41%), Gaps = 91/947 (9%)
Query: 25 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 144 KIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDI 203
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
D + L A + C LL+ D G TALHYA + L H
Sbjct: 204 CDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSH 263
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 264 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 323
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-----------------SKISQD 247
L+++ ++ D G A Y+ S+ I+ +L + +
Sbjct: 324 TLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKP 383
Query: 248 ADLKTPTKPKQHDQVSKISSERSGTPKKR---KAPPPPISPTQLSDVSSPRSITSTPLSG 304
A+LK + + + K++SE +R K P S + D + ++
Sbjct: 384 ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAM 443
Query: 305 KESVFFA--------EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 356
+ +A E + EI SI E S + ++ + A L+ L+
Sbjct: 444 LKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMI-TKTVARYSQQLNDLK 502
Query: 357 AKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSP 416
A+ A L N EL+ + K EAE +S HS+ L ++ + E + K
Sbjct: 503 AENARL---NSELEKEKHNKERLEAEV----ESLHSS---LATAINEYNEI--VERKDLE 550
Query: 417 SVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL----VC 471
VL + S + I QL + + L +++ + + L+ +L+ R L +
Sbjct: 551 LVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLA 610
Query: 472 LNNTEISENSSDLSQKLKETQSKYEEA-MKEVLSVQKQMKL-GLVSPESMDNYSHFHELR 529
L + ++ + ++KE + + KE S+ KQ L + + ++N +L
Sbjct: 611 LGSVQLDLRQA--QHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLE 668
Query: 530 VTEEE-------INVLKQDLQNALEE--SERNKEKVRE---LEEKLVEREKGTVIKPP-V 576
+E IN+ + L+N E+ ERNKE ++E L+EKL++ EK + V
Sbjct: 669 DARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIV 728
Query: 577 EEYEEMKSSYC---SVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDM 633
E++E + S+ E+ + + E KL Q+ + ++ E+
Sbjct: 729 REFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKL-----FQVEIQPEEKHEEF 783
Query: 634 KEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLM--QLT 691
++ + +I LN ++ + +E + E Y+K ++T ++ +E
Sbjct: 784 RK-LFELISLLNYTADQIRKKNRELEEEATGYKK---CLEMTINMLNAFANEDFSCHGDL 839
Query: 692 NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITEHLQV------ITTLR 744
N + K + ++K +++ ++ E + + V+ K+N V E L + L
Sbjct: 840 NTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLE 899
Query: 745 TAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMVPRSSYEKLQSSLESE 802
K +EE++ NLK H+ VE+ KL+ K L+E+A + +K Q+ E +
Sbjct: 900 KDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQK-QAEYEKQ 958
Query: 803 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-KEQEVNELLQKFQQ 861
+ L S+K+KE +V + S++K E + T L+ KE +
Sbjct: 959 LEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSM 1015
Query: 862 AQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 908
+++ + K+ A S+KL +K + +S T+ + L + L+
Sbjct: 1016 SKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLN 1062
Score = 45.1 bits (105), Expect = 3e-04
Identities = 78/395 (19%), Positives = 156/395 (39%), Gaps = 86/395 (21%)
Query: 624 QEASDEA--EDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHK 681
Q A D A D++ ++++ NK + + + A ++ +K E AE+ K
Sbjct: 341 QTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLK 400
Query: 682 -AEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-----ELTQLKQLVDAQKENSV---- 731
A EK +L + +D+ S K + + N ++ LK+ + A K +S+
Sbjct: 401 VASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 460
Query: 732 -------SITE-HLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 783
SITE + ++R K + + ++ + L + E A+L +L +EK
Sbjct: 461 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK---- 516
Query: 784 DAMVPRSSYEKLQSSLESEVSVLASKLKE------------------SVKEKEKVHSEVV 825
+ E+L++ +ES S LA+ + E V EK+ S +
Sbjct: 517 ------HNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNIS 570
Query: 826 QIRSE----VSQVKREKENIQTLLKSKEQEVNELLQK-----------FQQAQEELAEMK 870
Q+ + QV + + TL K K +E + L++ +QAQ + EMK
Sbjct: 571 QLTDKNELLTEQVHKARVKFNTL-KGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMK 629
Query: 871 RYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------- 921
+ + E K N + + + + +E N L + + + ++++
Sbjct: 630 QMHPNGEAKESQSIGKQNSLEERI-RQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 688
Query: 922 ------------EALQQQVKQLQNQLAECKKQHQE 944
+ L ++ L+ +L +C+K+ E
Sbjct: 689 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAE 723
>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1002
Score = 131 bits (330), Expect = 3e-30
Identities = 202/924 (21%), Positives = 385/924 (41%), Gaps = 91/924 (9%)
Query: 25 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 37 KIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDI 96
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
D + L A + C LL+ D G TALHYA + L H
Sbjct: 97 CDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSH 156
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 157 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 216
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-----------------SKISQD 247
L+++ ++ D G A Y+ S+ I+ +L + +
Sbjct: 217 TLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKP 276
Query: 248 ADLKTPTKPKQHDQVSKISSERSGTPKKR---KAPPPPISPTQLSDVSSPRSITSTPLSG 304
A+LK + + + K++SE +R K P S + D + ++
Sbjct: 277 ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAM 336
Query: 305 KESVFFA--------EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 356
+ +A E + EI SI E S + ++ + A L+ L+
Sbjct: 337 LKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMI-TKTVARYSQQLNDLK 395
Query: 357 AKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSP 416
A+ A L N EL+ + K EAE +S HS+ L ++ + E + K
Sbjct: 396 AENARL---NSELEKEKHNKERLEAEV----ESLHSS---LATAINEYNEI--VERKDLE 443
Query: 417 SVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL----VC 471
VL + S + I QL + + L +++ + + L+ +L+ R L +
Sbjct: 444 LVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLA 503
Query: 472 LNNTEISENSSDLSQKLKETQSKYEEA-MKEVLSVQKQMKL-GLVSPESMDNYSHFHELR 529
L + ++ + ++KE + + KE S+ KQ L + + ++N +L
Sbjct: 504 LGSVQLDLRQA--QHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLE 561
Query: 530 VTEEE-------INVLKQDLQNALEE--SERNKEKVRE---LEEKLVEREKGTVIKPP-V 576
+E IN+ + L+N E+ ERNKE ++E L+EKL++ EK + V
Sbjct: 562 DARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIV 621
Query: 577 EEYEEMKSSYC---SVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDM 633
E++E + S+ E+ + + E KL Q+ + ++ E+
Sbjct: 622 REFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKL-----FQVEIQPEEKHEEF 676
Query: 634 KEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLM--QLT 691
++ + +I LN ++ + +E + E Y+K ++T ++ +E
Sbjct: 677 RK-LFELISLLNYTADQIRKKNRELEEEATGYKK---CLEMTINMLNAFANEDFSCHGDL 732
Query: 692 NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITEHLQV------ITTLR 744
N + K + ++K +++ ++ E + + V+ K+N V E L + L
Sbjct: 733 NTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLE 792
Query: 745 TAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMVPRSSYEKLQSSLESE 802
K +EE++ NLK H+ VE+ KL+ K L+E+A + +K Q+ E +
Sbjct: 793 KDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQK-QAEYEKQ 851
Query: 803 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-KEQEVNELLQKFQQ 861
+ L S+K+KE +V + S++K E + T L+ KE +
Sbjct: 852 LEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSM 908
Query: 862 AQEELAEMKRYAESSSKLEEDKDK 885
+++ + K+ A S+KL +K++
Sbjct: 909 SKKLMKSDKKIAVISTKLFMEKER 932
Score = 45.1 bits (105), Expect = 3e-04
Identities = 78/395 (19%), Positives = 156/395 (39%), Gaps = 86/395 (21%)
Query: 624 QEASDEA--EDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHK 681
Q A D A D++ ++++ NK + + + A ++ +K E AE+ K
Sbjct: 234 QTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLK 293
Query: 682 -AEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-----ELTQLKQLVDAQKENSV---- 731
A EK +L + +D+ S K + + N ++ LK+ + A K +S+
Sbjct: 294 VASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 353
Query: 732 -------SITE-HLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 783
SITE + ++R K + + ++ + L + E A+L +L +EK
Sbjct: 354 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK---- 409
Query: 784 DAMVPRSSYEKLQSSLESEVSVLASKLKE------------------SVKEKEKVHSEVV 825
+ E+L++ +ES S LA+ + E V EK+ S +
Sbjct: 410 ------HNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNIS 463
Query: 826 QIRSE----VSQVKREKENIQTLLKSKEQEVNELLQK-----------FQQAQEELAEMK 870
Q+ + QV + + TL K K +E + L++ +QAQ + EMK
Sbjct: 464 QLTDKNELLTEQVHKARVKFNTL-KGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMK 522
Query: 871 RYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------- 921
+ + E K N + + + + +E N L + + + ++++
Sbjct: 523 QMHPNGEAKESQSIGKQNSLEERI-RQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 581
Query: 922 ------------EALQQQVKQLQNQLAECKKQHQE 944
+ L ++ L+ +L +C+K+ E
Sbjct: 582 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAE 616
>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 131 bits (330), Expect = 3e-30
Identities = 206/947 (21%), Positives = 393/947 (41%), Gaps = 91/947 (9%)
Query: 25 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 144 KIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDI 203
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
D + L A + C LL+ D G TALHYA + L H
Sbjct: 204 CDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSH 263
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 264 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 323
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-----------------SKISQD 247
L+++ ++ D G A Y+ S+ I+ +L + +
Sbjct: 324 TLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKP 383
Query: 248 ADLKTPTKPKQHDQVSKISSERSGTPKKR---KAPPPPISPTQLSDVSSPRSITSTPLSG 304
A+LK + + + K++SE +R K P S + D + ++
Sbjct: 384 ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAM 443
Query: 305 KESVFFA--------EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 356
+ +A E + EI SI E S + ++ + A L+ L+
Sbjct: 444 LKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMI-TKTVARYSQQLNDLK 502
Query: 357 AKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSP 416
A+ A L N EL+ + K EAE +S HS+ L ++ + E + K
Sbjct: 503 AENARL---NSELEKEKHNKERLEAEV----ESLHSS---LATAINEYNEI--VERKDLE 550
Query: 417 SVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL----VC 471
VL + S + I QL + + L +++ + + L+ +L+ R L +
Sbjct: 551 LVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLA 610
Query: 472 LNNTEISENSSDLSQKLKETQSKYEEA-MKEVLSVQKQMKL-GLVSPESMDNYSHFHELR 529
L + ++ + ++KE + + KE S+ KQ L + + ++N +L
Sbjct: 611 LGSVQLDLRQA--QHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLE 668
Query: 530 VTEEE-------INVLKQDLQNALEE--SERNKEKVRE---LEEKLVEREKGTVIKPP-V 576
+E IN+ + L+N E+ ERNKE ++E L+EKL++ EK + V
Sbjct: 669 DARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIV 728
Query: 577 EEYEEMKSSYC---SVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDM 633
E++E + S+ E+ + + E KL Q+ + ++ E+
Sbjct: 729 REFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKL-----FQVEIQPEEKHEEF 783
Query: 634 KEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLM--QLT 691
++ + +I LN ++ + +E + E Y+K ++T ++ +E
Sbjct: 784 RK-LFELISLLNYTADQIRKKNRELEEEATGYKK---CLEMTINMLNAFANEDFSCHGDL 839
Query: 692 NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITEHLQV------ITTLR 744
N + K + ++K +++ ++ E + + V+ K+N V E L + L
Sbjct: 840 NTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLE 899
Query: 745 TAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMVPRSSYEKLQSSLESE 802
K +EE++ NLK H+ VE+ KL+ K L+E+A + +K Q+ E +
Sbjct: 900 KDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQK-QAEYEKQ 958
Query: 803 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-KEQEVNELLQKFQQ 861
+ L S+K+KE +V + S++K E + T L+ KE +
Sbjct: 959 LEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSM 1015
Query: 862 AQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 908
+++ + K+ A S+KL +K + +S T+ + L + L+
Sbjct: 1016 SKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLN 1062
Score = 45.1 bits (105), Expect = 3e-04
Identities = 78/395 (19%), Positives = 156/395 (39%), Gaps = 86/395 (21%)
Query: 624 QEASDEA--EDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHK 681
Q A D A D++ ++++ NK + + + A ++ +K E AE+ K
Sbjct: 341 QTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLK 400
Query: 682 -AEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-----ELTQLKQLVDAQKENSV---- 731
A EK +L + +D+ S K + + N ++ LK+ + A K +S+
Sbjct: 401 VASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 460
Query: 732 -------SITE-HLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 783
SITE + ++R K + + ++ + L + E A+L +L +EK
Sbjct: 461 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK---- 516
Query: 784 DAMVPRSSYEKLQSSLESEVSVLASKLKE------------------SVKEKEKVHSEVV 825
+ E+L++ +ES S LA+ + E V EK+ S +
Sbjct: 517 ------HNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNIS 570
Query: 826 QIRSE----VSQVKREKENIQTLLKSKEQEVNELLQK-----------FQQAQEELAEMK 870
Q+ + QV + + TL K K +E + L++ +QAQ + EMK
Sbjct: 571 QLTDKNELLTEQVHKARVKFNTL-KGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMK 629
Query: 871 RYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------- 921
+ + E K N + + + + +E N L + + + ++++
Sbjct: 630 QMHPNGEAKESQSIGKQNSLEERI-RQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 688
Query: 922 ------------EALQQQVKQLQNQLAECKKQHQE 944
+ L ++ L+ +L +C+K+ E
Sbjct: 689 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAE 723
>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
sapiens]
Length = 823
Score = 127 bits (318), Expect = 7e-29
Identities = 165/809 (20%), Positives = 321/809 (39%), Gaps = 104/809 (12%)
Query: 25 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ +A GDA +V L ++ D + +TA HLA A GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGELDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDV 95
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 245
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 246 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 305
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 306 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 365
S+ +P + E +++ R + T A+ L ++SE +QQ
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQQ----------RHERSE 379
Query: 366 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 417
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 418 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 476
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 477 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 521
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 WDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 522 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 563
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 564 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 618
V+ E+ + + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTQDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD-- 676
Query: 619 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 664
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNNLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 665 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLKQ 721
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK+
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDFVLEEKSKKLMNECDHLKE 794
Query: 722 LVDAQKENSVSITEHLQVITTLRTAAKEM 750
+ + + ++ +T+ K++
Sbjct: 795 SLFQYEREKTEVVVSIKEDKYFQTSRKKI 823
Score = 43.5 bits (101), Expect = 0.001
Identities = 59/317 (18%), Positives = 128/317 (40%), Gaps = 30/317 (9%)
Query: 627 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 686
S E ED A+ + N Q Q A E + +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQQRHERSEKKQPQVKEGNNTNKSE 395
Query: 687 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 746
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 747 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 798
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDEN 514
Query: 799 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 853
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 854 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 905
E ++QQ +L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 906 QLSYSTSSSKRQSQQLE 922
L + ++ S Q+E
Sbjct: 629 NLKLALERTQDVSVQVE 645
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
sapiens]
Length = 823
Score = 126 bits (316), Expect = 1e-28
Identities = 170/808 (21%), Positives = 319/808 (39%), Gaps = 108/808 (13%)
Query: 25 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ +A GDA +V L ++ D + +TA HLA A GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDV 95
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 245
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 246 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 305
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 306 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 365
S+ +P + E +++ R + T A+ L ++SE +Q+
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQE----------RHERSE 379
Query: 366 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 417
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 418 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 476
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 477 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 521
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 522 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 563
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 564 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 618
V+ E+ + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD-- 676
Query: 619 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 664
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 665 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLK- 720
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKE 794
Query: 721 ---QLVDAQKENSVSITEHLQVITTLRT 745
Q + E VSI E T+ +T
Sbjct: 795 SLFQYEREKTEGVVSIKEDKYFQTSRKT 822
Score = 43.1 bits (100), Expect = 0.001
Identities = 59/317 (18%), Positives = 128/317 (40%), Gaps = 30/317 (9%)
Query: 627 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 686
S E ED A+ + N Q Q A E ++ +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSE 395
Query: 687 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 746
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 747 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 798
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDEN 514
Query: 799 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 853
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 854 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 905
E ++QQ L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 906 QLSYSTSSSKRQSQQLE 922
L + ++ S Q+E
Sbjct: 629 NLKLALERTRDVSVQVE 645
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
sapiens]
Length = 823
Score = 124 bits (311), Expect = 4e-28
Identities = 168/798 (21%), Positives = 315/798 (39%), Gaps = 108/798 (13%)
Query: 25 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ +A GDA +V L ++ D + +TA HLA A GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDV 95
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 245
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 246 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 305
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 306 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 365
S+ +P + E +++ R + T A+ L ++SE +Q+
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQE----------RHERSE 379
Query: 366 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 417
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 418 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 476
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 477 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 521
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 522 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 563
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 564 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 618
V+ E+ + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD-- 676
Query: 619 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 664
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 665 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLK- 720
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKE 794
Query: 721 ---QLVDAQKENSVSITE 735
Q + E VSI E
Sbjct: 795 SLFQYEREKTEGVVSIKE 812
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/317 (18%), Positives = 129/317 (40%), Gaps = 30/317 (9%)
Query: 627 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 686
S E ED A+ + N Q Q A E ++ +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSE 395
Query: 687 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 746
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 747 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 798
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDEN 514
Query: 799 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 853
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 854 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 905
E ++QQ +L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 906 QLSYSTSSSKRQSQQLE 922
L + ++ S Q+E
Sbjct: 629 NLKLALERTRDVSVQVE 645
>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
sapiens]
Length = 823
Score = 123 bits (309), Expect = 7e-28
Identities = 169/808 (20%), Positives = 318/808 (39%), Gaps = 108/808 (13%)
Query: 25 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ +A GDA +V L ++ D + +TA HLA GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACTSGHVQVVTLLVNRKCQIDV 95
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 245
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 246 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 305
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 306 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 365
S+ +P + E +++ R + T A+ L ++SE +Q+
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQE----------RHERSE 379
Query: 366 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 417
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 418 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 476
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 477 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 521
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 WDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 522 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 563
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 564 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 618
V+ E+ + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKAENEFLTEQLSETQIKFNALKD-- 676
Query: 619 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 664
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 665 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLK- 720
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKE 794
Query: 721 ---QLVDAQKENSVSITEHLQVITTLRT 745
Q + E VSI E T+ +T
Sbjct: 795 SLFQYEREKTEGVVSIKEDKYFQTSRKT 822
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/317 (18%), Positives = 129/317 (40%), Gaps = 30/317 (9%)
Query: 627 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 686
S E ED A+ + N Q Q A E ++ +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSE 395
Query: 687 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 746
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 747 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 798
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDEN 514
Query: 799 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 853
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 854 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 905
E ++QQ +L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 906 QLSYSTSSSKRQSQQLE 922
L + ++ S Q+E
Sbjct: 629 NLKLALERTRDVSVQVE 645
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 117 bits (294), Expect = 4e-26
Identities = 154/733 (21%), Positives = 327/733 (44%), Gaps = 96/733 (13%)
Query: 323 RENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT--------LHNKELQDKLQ 374
R+ + L T + LD S A QQ+L S + +V L H ++Q+ Q
Sbjct: 1135 RDLGEELEALKTELEDTLD--STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 375 AKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRI 434
S E + + +L + + E + + VL+ G D++ +
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAK-QTLENERGELANEVKVLLQGKG----DSEHKR 1247
Query: 435 QQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLN---------NTEISENSSDLS 485
++++ LQ+LQ + E R +L ++ + EL + +++++++ S L
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 486 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEI--NVLKQ--- 540
+L++TQ +E ++ LS+ ++K + D + F E EEE N+ KQ
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLK------QVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361
Query: 541 ------DLQNALEESERNKEKVRELEEKLVEREKGTVIK--PPVEEYEEMKSSYCSVIEN 592
D++ +E+S E E++ KL + +G + V Y++++ + + +
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Query: 593 MN---------KEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKE------AM 637
++ ++ A EK Q+ ++++ + T+ ++ +E + +E ++
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL 1481
Query: 638 NRMIDELNKQVSELSQLYKEAQAELEDY---------------RKRKSLEDVTAEYIHKA 682
R ++E +Q +EL +L K+ + E+ED + +++LE E +
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541
Query: 683 EH-EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQL-----KQLVDAQKENSVSITEH 736
E E +Q T ++ + E L MK+Q+ + L + KQLV +E + +
Sbjct: 1542 EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE 1601
Query: 737 LQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQ 796
+ + A K++E + +L+ H+ S + KQL + +A M D M +L
Sbjct: 1602 RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM------RELD 1655
Query: 797 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELL 856
+ S +LA + KE+ K+ + + +E++Q++ E++ +R K Q + +++ +E+
Sbjct: 1656 DTRASREEILA-QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ---QERDELADEIA 1711
Query: 857 QKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKR 916
+ L E +R ++LEE+ +++ +LK+A + Q++ + +
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERS 1771
Query: 917 QSQQLEALQQQVKQLQNQLAECKKQHQE--VISVYRMHL--LYAVQGQMDEDVQKVLKQI 972
+Q+ E +QQ+++ QN+ + K Q E V S Y+ + L A Q++E + K+
Sbjct: 1772 HAQKNENARQQLER-QNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830
Query: 973 LTMCK--NQSQKK 983
CK +++KK
Sbjct: 1831 QAACKQVRRTEKK 1843
Score = 103 bits (256), Expect = 1e-21
Identities = 143/691 (20%), Positives = 304/691 (43%), Gaps = 106/691 (15%)
Query: 334 TGADSLLDISSE-----ADQQDLLSLLQAKVASL-------TLHNKELQDKLQAKSPKEA 381
T LL +S + A +++L+ + + ++A+ TL ++ + +KLQ + +A
Sbjct: 832 TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA 891
Query: 382 EADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQ--- 438
E +L ++ +L L K + H L + + R Q LQ
Sbjct: 892 ETELCAEA-----EELRARLTA--------KKQELEEICHDLEARVEEEEERCQHLQAEK 938
Query: 439 ----EILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI--SENSSDLSQKLKETQ 492
+ +Q+L+++LE E+ R++LQ+E + A+L L +I + + L+++ K +
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998
Query: 493 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 552
+ E + +++ K S+ + HE +T+ E + +++ Q E R
Sbjct: 999 DRIAEFTTNLTEEEEKSK-------SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 553 K---------EKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 603
K +++ EL+ ++ E +K + + EE + + +E +K +K
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAE------LKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 604 YQEAQEEIMKLKDTLKSQMT--QEASDEAEDMKEAMNRMIDELNKQV-SELSQLYKEAQA 660
+E + +I +L++ L+S+ +A + D+ E + + EL + S +Q ++
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 661 ELEDYRKRKSLEDVTAEY----------IHKAEHEKLMQLTNVSRAKA--EDALSEMKSQ 708
E E +K+LE+ + +A E QL R KA E A ++++
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 709 YSKVLNELTQL----------KQLVDAQ-KENSVSITEHLQVITTLRTAAKEMEEKISNL 757
++ NE+ L ++ V+AQ +E V E +V T L +++ ++ N+
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 758 KEHLASKEVEVAKLEKQL--LEEKAAMTDAMVPRSSYEKLQSS-----LESEVSVLASKL 810
L+ + + +KL K LE + T ++ + +KL S +E E + +L
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 811 KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQK-----FQQAQEE 865
+E + K + ++ + ++V+ +K++ E+ L++ E EV LQK Q+ +E+
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE-EVKRKLQKDLEGLSQRHEEK 1404
Query: 866 LAEMKRYAESSSKLEEDKDK---KINEMSKEVTKLKEALNSLSQL--SYSTSSSK----R 916
+A + ++ ++L+++ D ++ + L++ QL T S+K R
Sbjct: 1405 VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464
Query: 917 QSQQLEALQQQVK--QLQNQLAECKKQHQEV 945
+ EA +++ K L L E +Q E+
Sbjct: 1465 DRAEAEAREKETKALSLARALEEAMEQKAEL 1495
Score = 86.7 bits (213), Expect = 1e-16
Identities = 162/856 (18%), Positives = 338/856 (39%), Gaps = 151/856 (17%)
Query: 160 LLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDS 219
L ++ S+I D ++ SRNK+ + L E+ EAL + D +DS
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL------EALKTELEDT--LDS 1154
Query: 220 LGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAP 279
SK + I L + ++ + + ++H Q + +E+ K+ KA
Sbjct: 1155 TAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKAN 1214
Query: 280 PPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIR-----------ENKDR 328
T ++ + L GK +A++ ++ E D+
Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK 1274
Query: 329 LSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFD 388
++ D++ + S++D + S L ++L ++ Q+ LQ ++ ++
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKS--SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK 1332
Query: 389 SYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRL 448
+ L + E H+L K ++ +++ ++D L
Sbjct: 1333 QVEDEKNSFREQLEEEEEAK------------HNLEKQIATLHAQVADMKKKMEDSVGCL 1380
Query: 449 ESSEAERKQLQVELQ--SRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQ 506
E++E +++LQ +L+ S+R E ++ + + L Q+L + + + +++
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440
Query: 507 KQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEK-----VRELEE 561
K+ K F +L E+ I+ + ++ E R KE R LEE
Sbjct: 1441 KKQK-------------KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEE 1487
Query: 562 KLVER-EKGTVIKPPVEEYEEMKSSYCSV---IENMNKEKAFLFEKYQEAQEEIMKLKDT 617
+ ++ E + K E E++ SS V + + K K L ++ +E + ++ +L+D
Sbjct: 1488 AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE 1547
Query: 618 LKSQMTQEASDEAEDMKEAMNRMID--------ELNKQVSELSQLYKEAQAELEDYRKRK 669
L Q T++A E +AM + + ++ +L + +E +AELED RK++
Sbjct: 1548 L--QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605
Query: 670 S------------LEDVTA--EYIHKAEHEKLMQLTNV-------------SRAKAEDAL 702
S L+D+ A + +K E + QL + +RA E+ L
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 703 SEMKSQYSKVLN---ELTQLKQ----------------------LVDAQKENSVSITEHL 737
++ K K+ + E+ QL++ + ++ + ++++ E
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725
Query: 738 QVITTLRTAAKEMEEKISNL------------------------KEHLASKEVEVAKLEK 773
++ + +E+EE+ N + H E +LE+
Sbjct: 1726 RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER 1785
Query: 774 QLLEEKAAMTDAM-VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEV----VQIR 828
Q E K + + +S Y+ ++LE++++ L +L KE++ +V +++
Sbjct: 1786 QNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK 1845
Query: 829 SEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLE---EDKDK 885
+ QV E+ N + ++ L Q +Q +E E +R S KL+ ED +
Sbjct: 1846 DVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1905
Query: 886 KINEMSKEVTKLKEAL 901
+ M++EV+ LK L
Sbjct: 1906 TADAMNREVSSLKNKL 1921
Score = 81.3 bits (199), Expect = 4e-15
Identities = 105/586 (17%), Positives = 246/586 (41%), Gaps = 63/586 (10%)
Query: 317 AEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNK-------EL 369
A + + K RL D L+D+ + L Q K L K E
Sbjct: 1406 AAYDKLEKTKTRLQQELD--DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 370 QDKLQAKSPKEAEADLSF----DSYHSTQTDLGPSLGKPGETSPPD---SKSSPSVLIHS 422
+D+ +A++ ++ LS + + +L L K T D SK +H
Sbjct: 1464 RDRAEAEAREKETKALSLARALEEAMEQKAEL-ERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 423 LGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS 482
L KS + ++++++ L++L+ L+++E + +L+V LQ+ +A+ ++
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF----ERDLQGRDE 1578
Query: 483 DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDL 542
+K K+ + E E+ +KQ + + + + ++ +L+ E I+ ++
Sbjct: 1579 QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM-----DLKDLEAHIDSANKNR 1633
Query: 543 QNALEESER----NKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA 598
A+++ + K+ +REL++ RE+ ++ E +++KS +I+ + +E A
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREE--ILAQAKENEKKLKSMEAEMIQ-LQEELA 1690
Query: 599 FLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEA 658
++AQ+E +D L ++ + A ++E L ++++L + +E
Sbjct: 1691 AAERAKRQAQQE----RDELADEIANSSGKGALALEEKRR-----LEARIAQLEEELEEE 1741
Query: 659 QAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQ 718
Q E R ++ + I+ + L K E+A +++ Q ++ +L +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTD-----LNLERSHAQKNENARQQLERQNKELKVKLQE 1796
Query: 719 LKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEE 778
++ V ++ + S++ +E KI+ L+E L ++ E KQ+
Sbjct: 1797 MEGTVKSKYKASITA----------------LEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 779 KAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREK 838
+ + D ++ + + + +++LK+ ++ E+ E + + +++RE
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 839 ENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKD 884
E+ + +EV+ L K ++ +R A + D++
Sbjct: 1901 EDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEE 1946
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 117 bits (293), Expect = 5e-26
Identities = 70/209 (33%), Positives = 104/209 (49%), Gaps = 1/209 (0%)
Query: 20 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 79
N LL A G A V +LL GA+ DSEG+T +A+A+G+VE +R ++ G
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFW-GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
Query: 80 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 139
+D +D G + LH+AA H L++ +D+ G+ A+ +G VQ
Sbjct: 838 LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
Query: 140 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIG 199
IL E+KS I+ + DG L +A GH +I L HGADVN ++ GR L +
Sbjct: 898 ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
Query: 200 SSNAVEALIKKGADLNLVDSLGYNALHYS 228
E ++ GA++ D+ G ALH S
Sbjct: 958 QLTMAEYFLENGANVEASDAEGRTALHVS 986
Score = 116 bits (290), Expect = 1e-25
Identities = 104/398 (26%), Positives = 179/398 (44%), Gaps = 28/398 (7%)
Query: 15 KTNEWNKNDDRL--LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 72
+TNE + ND R+ + A + G + V LL K ++ + +G+ A +AA +GH + +
Sbjct: 872 RTNEID-NDGRIPFILASQEGHYDCVQILLENK-SNIDQRGYDGRNALRVAALEGHRDIV 929
Query: 73 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 132
++ +HG DV +D G L++ A + L++ E+ D+ G+TALH + Q
Sbjct: 930 ELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQ 989
Query: 133 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 192
G ++ VQ+L + + +N D + L A GH ++ L++HGA V+ G TAL
Sbjct: 990 GHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATAL 1049
Query: 193 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL--LSKISQDADL 250
+A + G + V+ L++ GAD N D G A+ + + ++ I LL S +
Sbjct: 1050 CIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCS 1109
Query: 251 KTPTKPKQHDQVSKISSE-RSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVF 309
+P + + +SS+ +S T K + Q S R + + P S
Sbjct: 1110 PSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQ----PSLRGLPNGPTHAFSS-- 1163
Query: 310 FAEPPFKAEISSIRENKDRLSDSTTGA---DSLLDISSEADQQDLLSLLQAKVASLTLHN 366
P ++ S++ K LS+++ + SL SS A Q V + HN
Sbjct: 1164 ----PSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQ--------TVPIDSFHN 1211
Query: 367 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKP 404
+++Q S + + S S ST LG S P
Sbjct: 1212 LSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSP 1249
Score = 111 bits (277), Expect = 4e-24
Identities = 74/230 (32%), Positives = 109/230 (47%), Gaps = 5/230 (2%)
Query: 17 NEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMI 76
N+ + N LL + V +LL +GA D+ G T LAA +GH + + +I
Sbjct: 539 NQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLI 598
Query: 77 THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQ 136
G ++ D G +AL AA H E + LL + + D+ +TAL AA G
Sbjct: 599 GCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED 658
Query: 137 AVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLA- 195
V L +H + +N D +G L+ A GH EI LLDHGA+VN + GRTAL +A
Sbjct: 659 IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA 718
Query: 196 ----CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 241
G ++ V LI +GA+++ D G L + + + LLL
Sbjct: 719 LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLL 768
Score = 110 bits (276), Expect = 5e-24
Identities = 81/247 (32%), Positives = 120/247 (48%), Gaps = 16/247 (6%)
Query: 20 NKNDDR----LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVM 75
N DDR + QA+E D+ + +LL GAS + DS G+T AA G ++ + ++
Sbjct: 508 NSEDDRTSCIVRQALEREDS--IRTLLDN-GASVNQCDSNGRTLLANAAYSGSLDVVNLL 564
Query: 76 ITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCL 135
++ G D+ +D GH+ L LAA+ H + + L+ D G TAL AA G
Sbjct: 565 VSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHT 624
Query: 136 QAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLA 195
+ V L ++ D D L A GH +I LL HGA+VN + GRTAL+ A
Sbjct: 625 EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAA 684
Query: 196 CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL-----SENAGIQSLLLSKISQ---- 246
+G VE L+ GA++N D G AL + L +A + SLL+ + ++
Sbjct: 685 AYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHC 744
Query: 247 DADLKTP 253
D D TP
Sbjct: 745 DKDGMTP 751
Score = 108 bits (271), Expect = 2e-23
Identities = 68/205 (33%), Positives = 100/205 (48%), Gaps = 5/205 (2%)
Query: 27 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 86
L+A G E + L + GA K D+EG+TA AA GH E + ++ HG +V +D
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707
Query: 87 TTGHSALHLAA-----KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQIL 141
G +AL +AA H + L+ + D G T L AA +G + V +L
Sbjct: 708 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 767
Query: 142 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSS 201
E + ++ D +G PLL A GH+ + + LL GA V+S + GRT L +A G+
Sbjct: 768 LEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNV 827
Query: 202 NAVEALIKKGADLNLVDSLGYNALH 226
V L+ +G D N D G+ LH
Sbjct: 828 EVVRTLLDRGLDENHRDDAGWTPLH 852
Score = 108 bits (270), Expect = 2e-23
Identities = 70/223 (31%), Positives = 108/223 (48%), Gaps = 6/223 (2%)
Query: 26 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 85
L A G E V++LL G D++ +TA AA GH + + ++ HG +V
Sbjct: 615 LRSAAWGGHTEVVSALL-YAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKA 673
Query: 86 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAA-----AQGCLQAVQI 140
D G +AL AA H E + LL D G+TAL AA ++G V +
Sbjct: 674 DNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSL 733
Query: 141 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 200
L + + ++ D DG PLL+A GH ++ LL+ GADV+ + +GRT L+ A +G
Sbjct: 734 LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGH 793
Query: 201 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 243
++ V L+ GA ++ +DS G L + N + LL +
Sbjct: 794 ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Score = 106 bits (264), Expect = 1e-22
Identities = 67/205 (32%), Positives = 103/205 (50%)
Query: 38 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAA 97
V SLL +GA D +G T +AA +GHV+ + +++ G DV D G + L AA
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
Query: 98 KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNI 157
H + LL +S+DS G+T L A+AQG ++ V+ L + N +D G
Sbjct: 790 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWT 849
Query: 158 PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLV 217
PL +A GH IC L++ GA N + GR +LA + G + V+ L++ ++++
Sbjct: 850 PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQR 909
Query: 218 DSLGYNALHYSKLSENAGIQSLLLS 242
G NAL + L + I LL S
Sbjct: 910 GYDGRNALRVAALEGHRDIVELLFS 934
Score = 104 bits (259), Expect = 5e-22
Identities = 63/213 (29%), Positives = 102/213 (47%), Gaps = 1/213 (0%)
Query: 29 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 88
A G+ E V +LL + G D G T H+AA +GH +I G D
Sbjct: 821 ASAQGNVEVVRTLLDR-GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 879
Query: 89 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 148
G LA++ H++C++ LL++K + G+ AL AA +G V++L H + +
Sbjct: 880 GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
Query: 149 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 208
N KD DG L + + + L++GA+V + + GRTAL ++C G V+ LI
Sbjct: 940 NCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLI 999
Query: 209 KKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 241
AD+N D+ +AL + + + LL+
Sbjct: 1000 AYHADVNAADNEKRSALQSAAWQGHVKVVQLLI 1032
Score = 102 bits (254), Expect = 2e-21
Identities = 66/201 (32%), Positives = 98/201 (48%), Gaps = 1/201 (0%)
Query: 26 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 85
LL A G + V LL + GA D+ G+T AA+ GH + ++ G V +
Sbjct: 752 LLVAAYEGHVD-VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
Query: 86 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHK 145
D+ G + L +A+ + E +R LL D +G T LH AA +G + L E
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 146 SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVE 205
+ N D DG IP +LA Q GH + LL++ ++++ R GR AL +A G + VE
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 206 ALIKKGADLNLVDSLGYNALH 226
L GAD+N D+ G L+
Sbjct: 931 LLFSHGADVNCKDADGRPTLY 951
Score = 92.8 bits (229), Expect = 1e-18
Identities = 66/207 (31%), Positives = 100/207 (48%), Gaps = 6/207 (2%)
Query: 20 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAA-----AKGHVECLRV 74
N+ L+ A G E V LL GA D +G+TA +AA +KGH + +
Sbjct: 675 NEGRTALIAAAYMGHREIVEHLLDH-GAEVNHEDVDGRTALSVAALCVPASKGHASVVSL 733
Query: 75 MITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGC 134
+I G +V D G + L +AA H + + LL+ + D++G+T L AA+ G
Sbjct: 734 LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGH 793
Query: 135 LQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALML 194
V L + ++ D +G L +A G+ E+ LLD G D N R+ +G T L +
Sbjct: 794 ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHM 853
Query: 195 ACEIGSSNAVEALIKKGADLNLVDSLG 221
A G EALI++GA N +D+ G
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDG 880
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 117 bits (292), Expect = 7e-26
Identities = 165/745 (22%), Positives = 321/745 (43%), Gaps = 121/745 (16%)
Query: 304 GKESVFFAEPPFKAEISSIR-------ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 356
G E+ FAE K +I +R EN DS A + EA + L+ +++
Sbjct: 604 GTETAEFAE--LKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---EMEALRAKLMKVIK 658
Query: 357 AKVASLTL-----------HNKELQD---KLQAKSPKEAEADLSFDSYHSTQTDLGPSLG 402
K SL H E++D KLQ K E ++ + + QT + +
Sbjct: 659 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNF- 716
Query: 403 KPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERK------ 456
TS + + + +L K++++ +++L++ L+ +K+++ E E+
Sbjct: 717 ----TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 772
Query: 457 -QLQVELQSRRAELVCL--NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGL 513
+ ELQ R +L L N +E+S+ L ++L+ + K+ EA +E +SVQ+ M+
Sbjct: 773 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ--- 829
Query: 514 VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTV-I 572
++L EE+ N+L DL+ E + K RE +E+ + K +
Sbjct: 830 ---------ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 880
Query: 573 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD------------TLKS 620
+ + E +M S + MN E +E Q ++ K + T+K+
Sbjct: 881 ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKA 940
Query: 621 QMTQ-EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 679
+ +Q EA+ + E+ K+ + R + +L K++ +E +A E T+E
Sbjct: 941 EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER---------ATSET- 990
Query: 680 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQK-----ENSVSIT 734
K +HE+++Q + ED L + + S +L EL +L++ D K E+++ I
Sbjct: 991 -KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1049
Query: 735 EHLQVITTLRTAAKE--------MEEKISNLKEHLA------SKEVEVAKLEKQLLEEKA 780
E + T A+ E ++ ++ LKE+ +K E+ +E Q +EE
Sbjct: 1050 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109
Query: 781 AMTDAMVPRSSYEKLQ-SSLESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKR 836
+ + ++ + Q S+L+ E LA +L ++ V +K+ E + +++ ++K+
Sbjct: 1110 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1169
Query: 837 -----------EKENIQ-------TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSK 878
EK ++Q LL K+ E+ +L + + E A K
Sbjct: 1170 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1229
Query: 879 LEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 938
LE DK K ++ +LKE LS S +T + + ++ A + Q+ L + + +
Sbjct: 1230 LESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDER--AQESQIDFLNSVIVDL 1287
Query: 939 KKQHQEVISVYRMHLLYAVQGQMDE 963
++++Q++ M A+ G D+
Sbjct: 1288 QRKNQDLKMKVEMMSEAALNGNGDD 1312
Score = 92.8 bits (229), Expect = 1e-18
Identities = 144/694 (20%), Positives = 295/694 (42%), Gaps = 77/694 (11%)
Query: 270 SGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRL 329
S TP K KA S S RS +++ LS SV + + + E R
Sbjct: 285 STTPAKAKANAVRRVMATTS-ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 330 SDSTTGADSLLDISSEADQ--QDLLS---LLQAKVASLTLHNKELQDKL--------QAK 376
+ +G +L + E Q + LL+ L +A+VA T H E++ +L Q
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV 403
Query: 377 SPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQ 436
EA+ D + + L + E + + + +S T D+ +
Sbjct: 404 LELEAKMDQLRTMVEAADREKVELLNQLEE----EKRKVEDLQFRVEEESITKGDLEVAT 459
Query: 437 LQEI--LQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSK 494
+ E + +L+K L E +L+ L+S + + + + S L +KL+ T++
Sbjct: 460 VSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTD 519
Query: 495 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE 554
++ +E+ S+++ + L E+++ + L++ LE + +
Sbjct: 520 HQ---REITSLKEHF-----GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 571
Query: 555 KVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKL 614
V L + +E T I + EE+K S+ + E A L + ++ + +
Sbjct: 572 DVIALWKSKLE----TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE 627
Query: 615 KDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDV 674
+ L++Q E + A++M EA+ ++L ++ KE + LE R +
Sbjct: 628 IENLQNQQDSERAAHAKEM-EALR----------AKLMKVIKEKENSLEAIRSK------ 670
Query: 675 TAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-ELTQLK-----QLVDAQKE 728
+ KAE + L+++ ED L++++ KV E+ Q K +++D
Sbjct: 671 ----LDKAEDQHLVEM--------EDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 718
Query: 729 NSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP 788
+ E L + LR A+ E + ++ L++ L + E ++ LE + E + +
Sbjct: 719 QLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRE 778
Query: 789 RSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS 847
E ++L+ +S + S++KE++ KE + + + + E V+R + L
Sbjct: 779 LQGRELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
Query: 848 KEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 907
KE++ N L ++ +E LA+M+ +K E KD++ ++ K KL+ + + ++
Sbjct: 838 KEEQFNMLSSDLEKLRENLADME------AKFRE-KDEREEQLIKAKEKLENDIAEIMKM 890
Query: 908 SYSTSSS-KRQSQQLEALQQQVKQLQNQLAECKK 940
S SS + + +L ++ V++LQ +L + +
Sbjct: 891 SGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 924
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 117 bits (292), Expect = 7e-26
Identities = 165/745 (22%), Positives = 321/745 (43%), Gaps = 121/745 (16%)
Query: 304 GKESVFFAEPPFKAEISSIR-------ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 356
G E+ FAE K +I +R EN DS A + EA + L+ +++
Sbjct: 639 GTETAEFAE--LKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---EMEALRAKLMKVIK 693
Query: 357 AKVASLTL-----------HNKELQD---KLQAKSPKEAEADLSFDSYHSTQTDLGPSLG 402
K SL H E++D KLQ K E ++ + + QT + +
Sbjct: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNF- 751
Query: 403 KPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERK------ 456
TS + + + +L K++++ +++L++ L+ +K+++ E E+
Sbjct: 752 ----TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 807
Query: 457 -QLQVELQSRRAELVCL--NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGL 513
+ ELQ R +L L N +E+S+ L ++L+ + K+ EA +E +SVQ+ M+
Sbjct: 808 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ--- 864
Query: 514 VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTV-I 572
++L EE+ N+L DL+ E + K RE +E+ + K +
Sbjct: 865 ---------ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 915
Query: 573 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD------------TLKS 620
+ + E +M S + MN E +E Q ++ K + T+K+
Sbjct: 916 ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKA 975
Query: 621 QMTQ-EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 679
+ +Q EA+ + E+ K+ + R + +L K++ +E +A E T+E
Sbjct: 976 EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER---------ATSET- 1025
Query: 680 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQK-----ENSVSIT 734
K +HE+++Q + ED L + + S +L EL +L++ D K E+++ I
Sbjct: 1026 -KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1084
Query: 735 EHLQVITTLRTAAKE--------MEEKISNLKEHLA------SKEVEVAKLEKQLLEEKA 780
E + T A+ E ++ ++ LKE+ +K E+ +E Q +EE
Sbjct: 1085 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1144
Query: 781 AMTDAMVPRSSYEKLQ-SSLESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKR 836
+ + ++ + Q S+L+ E LA +L ++ V +K+ E + +++ ++K+
Sbjct: 1145 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1204
Query: 837 -----------EKENIQ-------TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSK 878
EK ++Q LL K+ E+ +L + + E A K
Sbjct: 1205 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1264
Query: 879 LEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 938
LE DK K ++ +LKE LS S +T + + ++ A + Q+ L + + +
Sbjct: 1265 LESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDER--AQESQIDFLNSVIVDL 1322
Query: 939 KKQHQEVISVYRMHLLYAVQGQMDE 963
++++Q++ M A+ G D+
Sbjct: 1323 QRKNQDLKMKVEMMSEAALNGNGDD 1347
Score = 91.7 bits (226), Expect = 3e-18
Identities = 144/714 (20%), Positives = 299/714 (41%), Gaps = 82/714 (11%)
Query: 270 SGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRL 329
S TP K KA S S RS +++ LS SV + + + E R
Sbjct: 285 STTPAKAKANAVRRVMATTS-ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 330 SDSTTGADSLLDISSEADQ--QDLLS---LLQAKVASLTLHNKELQDKL--------QAK 376
+ +G +L + E Q + LL+ L +A+VA T H E++ +L Q
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV 403
Query: 377 SPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQ 436
EA+ D + + L + E V S+ K + +++
Sbjct: 404 LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEH 463
Query: 437 LQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYE 496
+ +++L++ L + + +LQ EL+ R V + I E DL+ +++E
Sbjct: 464 AR--IKELEQSLLFEKTKADKLQRELEDTRVATVS-EKSRIMELEKDLALRVQE------ 514
Query: 497 EAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKV 556
V ++++++ + + + S E+ +E++ V + D Q + + +
Sbjct: 515 -----VAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR 569
Query: 557 RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFE-----------KYQ 605
E +K ++ + E+ + S S +E+ NKE + + +Q
Sbjct: 570 EETHQKEIK-----ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ 624
Query: 606 EAQEEIMKLKDT-----------LKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQL 654
+A EE+ LK+Q+ + D +++ N+ E E+ L
Sbjct: 625 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 684
Query: 655 YKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN 714
+ +++ K SLE + ++ + KAE + L+++ ED L++++ KV
Sbjct: 685 RAKLMKVIKE--KENSLEAIRSK-LDKAEDQHLVEM--------EDTLNKLQEAEIKVKE 733
Query: 715 -ELTQLK-----QLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEV 768
E+ Q K +++D + E L + LR A+ E + ++ L++ L + E ++
Sbjct: 734 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 793
Query: 769 AKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQI 827
LE + E + + E ++L+ +S + S++KE++ KE + + + +
Sbjct: 794 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEA 852
Query: 828 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 887
E V+R + L KE++ N L ++ +E LA+M+ +K E KD++
Sbjct: 853 SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADME------AKFRE-KDERE 905
Query: 888 NEMSKEVTKLKEALNSLSQLSYSTSSS-KRQSQQLEALQQQVKQLQNQLAECKK 940
++ K KL+ + + ++S SS + + +L ++ V++LQ +L + +
Sbjct: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 959
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/302 (19%), Positives = 128/302 (42%), Gaps = 47/302 (15%)
Query: 694 SRAKAEDALSEMKSQYSKVLNELTQLKQLV--------------DAQKENSVSITEHLQV 739
SR L+E S+Y++ ++ T L++ + D ++ T H+
Sbjct: 328 SRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGE 387
Query: 740 ITTLRTAAK--------EMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSS 791
I A+ E+E K+ L+ + + + E +L QL EEK + D
Sbjct: 388 IEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE 447
Query: 792 YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQE 851
+ LE++ + +++KE + ++ +++ +++RE E+ + S++
Sbjct: 448 ESITKGDLETQTKLEHARIKE-------LEQSLLFEKTKADKLQRELEDTRVATVSEKSR 500
Query: 852 VNELLQKFQQAQEELAEMKRYAESS----------------SKLEEDKDKKINEMSKEVT 895
+ EL + +E+AE++R ES+ S L+E + + +E+T
Sbjct: 501 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 560
Query: 896 KLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLY 955
LKE + + K E L ++ + L+++L K++ +VI++++ L
Sbjct: 561 SLKEHFGAREET--HQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 618
Query: 956 AV 957
A+
Sbjct: 619 AI 620
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 116 bits (291), Expect = 9e-26
Identities = 70/218 (32%), Positives = 104/218 (47%)
Query: 35 AEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALH 94
+E+ +L K A D +T H+AAA V+C V+I V D G +ALH
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 95 LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLD 154
AA N H E + LL + D + ALH+AA G L V +L H + + KD
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Query: 155 GNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 214
G PL A NG + LL+ G +++ N G TAL +AC G V LI GA++
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 215 NLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 252
N ++ G+ LH++ S + + LL D ++++
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Score = 105 bits (263), Expect = 2e-22
Identities = 81/244 (33%), Positives = 125/244 (51%), Gaps = 12/244 (4%)
Query: 22 NDDRLLQAVENGDAEKVASL--LGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 79
N + L +A E + E L L + A+ + D EG + H AAA GH +CL +++
Sbjct: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 80 VDVTAQDTTG--HSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 137
+ +G S LHLAA N HH+ + LLQS + D G+TAL AA +G +
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
Query: 138 VQILCEHKSPINLKD-LDGNIPLLLAVQNGHSEICHFLL---DHGADVNSRNKSGRTALM 193
V+ L + I +KD + PL +V NGH+ LL D+ V+ ++ G+T LM
Sbjct: 591 VEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLM 650
Query: 194 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL----SKISQDAD 249
LA G +AV L++K A+++ VD LG ALH ++ + +LL S + +D+
Sbjct: 651 LAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR 710
Query: 250 LKTP 253
+TP
Sbjct: 711 GRTP 714
Score = 105 bits (261), Expect = 3e-22
Identities = 64/194 (32%), Positives = 95/194 (48%), Gaps = 1/194 (0%)
Query: 33 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 92
GDAE + LL GA D+ T H A A E ++V+I H DV A+D +
Sbjct: 27 GDAE-IIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTP 85
Query: 93 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 152
LH+AA N +C ++ D G+TALH+AA G ++ V +L + IN D
Sbjct: 86 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 145
Query: 153 LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 212
L A GH ++ L++HGA+V ++K G T L A G N V+ L+ G
Sbjct: 146 KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGV 205
Query: 213 DLNLVDSLGYNALH 226
+++ ++ G ALH
Sbjct: 206 EIDEINVYGNTALH 219
Score = 101 bits (251), Expect = 4e-21
Identities = 59/190 (31%), Positives = 95/190 (50%)
Query: 53 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 112
DSE +T H+AA G E + ++I G V A+D + LH A + E ++ L++
Sbjct: 13 DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
Query: 113 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 172
+ D + +T LH AAA ++ +++ S +N+ D G L A NGH E+ +
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN 132
Query: 173 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 232
LL GA++N+ +K R AL A +G + V LI GA++ D GY LH + +
Sbjct: 133 LLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192
Query: 233 NAGIQSLLLS 242
+ LL+
Sbjct: 193 QINVVKHLLN 202
Score = 100 bits (248), Expect = 9e-21
Identities = 78/247 (31%), Positives = 110/247 (44%), Gaps = 33/247 (13%)
Query: 27 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 86
L A G + LL GA K D G+T H AAA H C+ ++T G +V D
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443
Query: 87 TTGHSALHLAAK-----------NSHHE-----------------CIRKLLQSKCPAESV 118
G +ALH AA N+H C+ LLQ+
Sbjct: 444 DWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIR 503
Query: 119 DSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNI---PLLLAVQNGHSEICHFLL 175
D G ++HYAAA G Q +++L E ++ ++ D PL LA NGH + LL
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLE-RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLL 562
Query: 176 DHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNA-LHYSKLSENA 234
D++ R++ GRTAL LA G + VEALI GA + + D++ LH S ++ +
Sbjct: 563 QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHT 622
Query: 235 GIQSLLL 241
LLL
Sbjct: 623 LCLRLLL 629
Score = 99.8 bits (247), Expect = 1e-20
Identities = 66/211 (31%), Positives = 99/211 (46%), Gaps = 1/211 (0%)
Query: 17 NEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMI 76
N +KN L A K A ++ +S D G+TA H AA GHVE + +++
Sbjct: 76 NARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL 135
Query: 77 THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQ 136
G ++ A D ALH AA H + + L+ D G T LH AA+ G +
Sbjct: 136 AKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQIN 195
Query: 137 AVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL-MLA 195
V+ L I+ ++ GN L +A NG + + L+D+GA+VN N +G T L A
Sbjct: 196 VVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAA 255
Query: 196 CEIGSSNAVEALIKKGADLNLVDSLGYNALH 226
+ +E L+ GAD+N+ G + LH
Sbjct: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLH 286
Score = 96.7 bits (239), Expect = 1e-19
Identities = 66/219 (30%), Positives = 98/219 (44%), Gaps = 28/219 (12%)
Query: 53 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 112
D +G T H+AA GH + + T G D LHLAA N+H +C RKLL S
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG 370
Query: 113 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 172
++ D G+T LH AAA G ++ +++L + + KD G PL A N H
Sbjct: 371 FEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIE 430
Query: 173 FLLDHGADVNSRNKSGRTALMLAC----------------------------EIGSSNAV 204
L+ GA+VN + GRTAL A E ++ +
Sbjct: 431 TLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCL 490
Query: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 243
E L++ A+ ++ D GYN++HY+ + LLL +
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER 529
Score = 89.7 bits (221), Expect = 1e-17
Identities = 73/287 (25%), Positives = 112/287 (39%), Gaps = 67/287 (23%)
Query: 9 LSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH 68
L AK N ++K D R L V +LL GA T D +G T H AA+ G
Sbjct: 134 LLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQ 193
Query: 69 VECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHY 128
+ ++ ++ GV++ + G++ALH+A N + +L+ +++G T LH+
Sbjct: 194 INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHF 253
Query: 129 AAAQG----CLQAV------------------------------QILCEHKSPINLKDLD 154
AAA CL+ + Q L ++ I+ D D
Sbjct: 254 AAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKD 313
Query: 155 GNI---------------------------------PLLLAVQNGHSEICHFLLDHGADV 181
GN PL LA N HS+ C LL G ++
Sbjct: 314 GNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEI 373
Query: 182 NSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 228
++ +K GRT L A G+ ++ L GAD + D G LHY+
Sbjct: 374 DTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
Score = 89.0 bits (219), Expect = 2e-17
Identities = 73/266 (27%), Positives = 112/266 (42%), Gaps = 35/266 (13%)
Query: 29 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH-VECLRVMITHGVDVTAQDT 87
A NG V L+ GA+ + ++ G T H AAA H CL +++ +G DV Q
Sbjct: 221 ACYNGQDAVVNELIDY-GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK 279
Query: 88 TGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 147
G S LH+ A + + L+Q+ + VD G T LH AA G + L +
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Query: 148 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIG-------- 199
+ PL LA N HS+ C LL G ++++ +K GRT L A G
Sbjct: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Query: 200 -SSNA------------------------VEALIKKGADLNLVDSLGYNALHYSKLSENA 234
SS A +E L+ GA++N D G ALHY+ S+
Sbjct: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMD 459
Query: 235 GIQSLLLSKISQDADLKTPTKPKQHD 260
+++L + +L+ + K+ +
Sbjct: 460 RNKTILGNAHDNSEELERARELKEKE 485
Score = 85.9 bits (211), Expect = 2e-16
Identities = 66/243 (27%), Positives = 103/243 (42%), Gaps = 42/243 (17%)
Query: 53 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 112
D++G+T LA A GH++ + +++ +V D G +ALH H EC++ LL+ +
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
Query: 113 CPAESVDSSGKTALHYAAAQG---CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSE 169
DS G+T LHYAAA+G L + + + KD G PL A NG+
Sbjct: 702 VSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNEN 761
Query: 170 I----------------------CHFLLDHG------------ADVNSRNKSGRTALMLA 195
C + DHG + V+ R+ GRT L A
Sbjct: 762 CIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAA 821
Query: 196 CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS-----QDADL 250
++ L++ A +N VD+ G AL + + AG +L++ +D DL
Sbjct: 822 AFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDL 881
Query: 251 KTP 253
TP
Sbjct: 882 NTP 884
Score = 81.3 bits (199), Expect = 4e-15
Identities = 61/231 (26%), Positives = 99/231 (42%), Gaps = 39/231 (16%)
Query: 26 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV---DV 82
L + + G E V LL ++ + K DS G+T H AAA+GH L ++ + D
Sbjct: 682 LHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
Query: 83 TAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESV------------------------ 118
+D G++ LH A N + CI LL+ KC + +
Sbjct: 741 CFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLG 800
Query: 119 ----------DSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHS 168
D G+T L AA ++ +Q+L H +P+N D G L++A +NG +
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQA 860
Query: 169 EICHFLLDHG-ADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 218
L++ AD+ ++K T L LAC G ++ K D +L++
Sbjct: 861 GAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLIN 911
Score = 76.6 bits (187), Expect = 1e-13
Identities = 49/162 (30%), Positives = 79/162 (48%)
Query: 81 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 140
DV D+ + LH+AA E I L+ S + D+ T LH A A +AVQ+
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 141 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 200
L +H + +N +D + PL +A N + ++ + VN ++ GRTAL A G
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 201 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 242
V L+ KGA++N D ALH++ + + +LL++
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Score = 73.2 bits (178), Expect = 1e-12
Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 10/169 (5%)
Query: 29 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD---VTAQ 85
A NG+ + LL +K K T H A H C +++ +D V+ +
Sbjct: 754 ACYNGNENCIEVLLEQK--CFRKFIGNPFTPLHCAIINDHGNCASLLLG-AIDSSIVSCR 810
Query: 86 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH- 144
D G + L AA H EC++ LL+ P +VD+SGKTAL AA G AV IL
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD---VNSRNKSGRT 190
++ + +KD D N PL LA GH + +LD D +N +N + +T
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNALQT 919
Score = 66.2 bits (160), Expect = 1e-10
Identities = 41/127 (32%), Positives = 69/127 (54%)
Query: 117 SVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLD 176
++DS +T LH AA G + +++L + +N KD PL AV + E L+
Sbjct: 11 TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIK 70
Query: 177 HGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGI 236
H ADVN+R+K+ +T L +A + E +I + +N+ D G ALH++ L+ + +
Sbjct: 71 HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEM 130
Query: 237 QSLLLSK 243
+LLL+K
Sbjct: 131 VNLLLAK 137
Score = 44.3 bits (103), Expect = 6e-04
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 144 HKSP-INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 202
HK+ +N D + PL +A G +EI L+ GA VN+++ T L A S
Sbjct: 4 HKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEE 63
Query: 203 AVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 245
AV+ LIK AD+N D LH + ++ +++ +S
Sbjct: 64 AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLS 106
Score = 39.7 bits (91), Expect = 0.014
Identities = 20/57 (35%), Positives = 28/57 (49%)
Query: 20 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMI 76
N L+ A ENG A V L+ A T D + T HLA +KGH +C +++
Sbjct: 845 NSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 115 bits (288), Expect = 2e-25
Identities = 64/202 (31%), Positives = 107/202 (52%), Gaps = 1/202 (0%)
Query: 26 LLQAVENGDAEKVASLLGK-KGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 84
++ A+ + + + LLG + + G +AA G+++ L+++I G +
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
QD G +A++ AA++ H + ++ L ++KCP + D SG+ ALH AA G Q+LC
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSF 467
Query: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
S N++D + PL A +G+ + L + G +VN +N+ G T L+ A G + V
Sbjct: 468 GSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIV 527
Query: 205 EALIKKGADLNLVDSLGYNALH 226
E L + GADLN D G+ ALH
Sbjct: 528 ECLAEHGADLNACDKDGHIALH 549
Score = 102 bits (254), Expect = 2e-21
Identities = 59/190 (31%), Positives = 93/190 (48%)
Query: 37 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 96
++ LL K+G+ D G A + AA GHV+ L+ + + + +D +G ALH+A
Sbjct: 393 QILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVA 452
Query: 97 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 156
A+ H + + L D +T LH AA G + LCE +N+K+ +G
Sbjct: 453 ARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGE 512
Query: 157 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 216
PLL A G+ +I L +HGAD+N+ +K G AL LA ++ L+ +G ++
Sbjct: 513 TPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDY 572
Query: 217 VDSLGYNALH 226
D G LH
Sbjct: 573 QDRHGNTPLH 582
Score = 96.7 bits (239), Expect = 1e-19
Identities = 58/184 (31%), Positives = 96/184 (52%), Gaps = 3/184 (1%)
Query: 53 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 112
D G+ A H+AA GH + +++ + G + QD + LH AA + ++ + L ++
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAG 501
Query: 113 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 172
C + G+T L A+A+G V+ L EH + +N D DG+I L LAV+ E+
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561
Query: 173 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 232
LL G V+ +++ G T L +AC+ G+ V AL + +L++ + G LH L+
Sbjct: 562 TLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLH---LAA 618
Query: 233 NAGI 236
N GI
Sbjct: 619 NNGI 622
Score = 92.4 bits (228), Expect = 2e-18
Identities = 54/158 (34%), Positives = 78/158 (49%)
Query: 38 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAA 97
VA L + G + + EG+T A+A+G+ + + + HG D+ A D GH ALHLA
Sbjct: 493 VAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAV 552
Query: 98 KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNI 157
+ E I+ LL C + D G T LH A G + V LCE +++ + G
Sbjct: 553 RRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRT 612
Query: 158 PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLA 195
PL LA NG ++ +L GA V + G+TA LA
Sbjct: 613 PLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
Score = 81.3 bits (199), Expect = 4e-15
Identities = 57/235 (24%), Positives = 104/235 (44%)
Query: 6 LPWLSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAA 65
L +LS + + +K+ + L VA LL G++ D E +T H AA
Sbjct: 428 LKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAW 487
Query: 66 KGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTA 125
G+ + + G +V ++ G + L A+ +H+ + L + + D G A
Sbjct: 488 HGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIA 547
Query: 126 LHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRN 185
LH A + ++ ++ L ++ +D GN PL +A ++G+ I L + +++ N
Sbjct: 548 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 607
Query: 186 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL 240
K GRT L LA G + V L GA + + + G A ++ ++ + LL
Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 44.7 bits (104), Expect = 4e-04
Identities = 31/110 (28%), Positives = 54/110 (49%), Gaps = 4/110 (3%)
Query: 148 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEAL 207
+N + G PLL+A G+ +I L+ G+ ++ ++K G A+ A G + ++ L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431
Query: 208 IKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS----QDADLKTP 253
+ L++ D G ALH + +A + LL S S QD + +TP
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETP 481
Score = 37.7 bits (86), Expect = 0.053
Identities = 17/49 (34%), Positives = 31/49 (63%)
Query: 180 DVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 228
DVN NK G L++A G+ ++ LIK+G+ +++ D G NA++++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWA 419
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 114 bits (284), Expect = 6e-25
Identities = 88/292 (30%), Positives = 128/292 (43%), Gaps = 47/292 (16%)
Query: 26 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 85
L+ +V NG + V SLL K GA+ D G+TA H A GH EC+ ++ HG +
Sbjct: 657 LMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR 715
Query: 86 DTTGHSALHLAAKNSHHECIRKLLQSKCPAES----VDSSGKTALHYAAAQGCLQAVQIL 141
D+ G + +HL+A H + LLQS ++ D+ G TALH+A G V++L
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 142 CEHK----------------------------------SPINLKDLDGNIPLLLAVQNGH 167
E + S +N D G PL A H
Sbjct: 776 LEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDH 835
Query: 168 SEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK-GADLNLVDSLGYNALH 226
E LL H A VNS + +G+T LM+A E G +N VE L+ A+L L D+ ALH
Sbjct: 836 VECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALH 895
Query: 227 YSKLSENAGIQSLLLSKISQ-------DADLKTPTKPKQHDQVSKISSERSG 271
+ + L+L KI+ +A L+TP + ++ + E G
Sbjct: 896 LACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLG 947
Score = 113 bits (283), Expect = 8e-25
Identities = 66/218 (30%), Positives = 104/218 (47%)
Query: 35 AEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALH 94
+E+ +L K A D +T H+AAA V+C ++ +V D G +ALH
Sbjct: 86 SEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALH 145
Query: 95 LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLD 154
AA + H E ++ LL + D + A+H+AA G ++ V++L H + + KD
Sbjct: 146 HAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205
Query: 155 GNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 214
PL A +G + +LLD G D+N N G T L +AC G V LI GA +
Sbjct: 206 SYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIV 265
Query: 215 NLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 252
N + G+ LH++ S + + LL D ++K+
Sbjct: 266 NQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKS 303
Score = 109 bits (273), Expect = 1e-23
Identities = 68/233 (29%), Positives = 116/233 (49%), Gaps = 4/233 (1%)
Query: 21 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 80
++ L+QA+ NGD ++V +L+ KK D+E +T H AA G E + ++I G
Sbjct: 7 RDQPSLVQAIFNGDPDEVRALIFKK-EDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
Query: 81 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 140
V A+D+ + LH A + E ++ LL+ + D + +T LH AAA ++ +
Sbjct: 66 RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
Query: 141 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 200
L S +N+ D G L A +GH E+ LL GA++N+ +K R A+ A +G
Sbjct: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
Query: 201 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP 253
V+ L+ GA++ D Y LH + ++G+ S++ + D+ P
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLH---AAASSGMISVVKYLLDLGVDMNEP 235
Score = 106 bits (264), Expect = 1e-22
Identities = 69/210 (32%), Positives = 100/210 (47%), Gaps = 1/210 (0%)
Query: 44 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 103
+ GA D G T H+AA GH + +IT G D + G LHLAA + +
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
Query: 104 CIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAV 163
C RKLL S ++ D G+T LH AAA G L+ + +L + N KD G PL A
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Query: 164 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-AVEALIKKGADLNLVDSLGY 222
N + + L+ GA VN ++ G T L A + +E L++ A+ + D GY
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
Query: 223 NALHYSKLSENAGIQSLLLSKISQDADLKT 252
NA+HYS + L+ S+ D ++T
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMET 536
Score = 104 bits (260), Expect = 4e-22
Identities = 67/197 (34%), Positives = 109/197 (55%), Gaps = 5/197 (2%)
Query: 61 HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDS 120
HLAA GH + L V++ +D+ ++++G + L LAA H EC+ L+ D
Sbjct: 555 HLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDY 614
Query: 121 SGK-TALHYAAAQGCLQAVQILCEHKSP---INLKDLDGNIPLLLAVQNGHSEICHFLLD 176
K T +H AA G + +++L + P ++++D +G PL+L+V NGH++ + LL+
Sbjct: 615 ILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLN 674
Query: 177 HGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGI 236
GA+V++++K GRTAL G V+AL++ GA L DS G +H S + G+
Sbjct: 675 KGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGV 734
Query: 237 -QSLLLSKISQDADLKT 252
+LL S S DA+ T
Sbjct: 735 LGALLQSAASMDANPAT 751
Score = 99.8 bits (247), Expect = 1e-20
Identities = 66/215 (30%), Positives = 100/215 (46%), Gaps = 1/215 (0%)
Query: 17 NEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMI 76
N +KN L A K A L ++ D G+TA H AA GH E +++++
Sbjct: 101 NARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLL 160
Query: 77 THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQ 136
+ G ++ A D A+H AA H E ++ L+ D T LH AA+ G +
Sbjct: 161 SRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMIS 220
Query: 137 AVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL-MLA 195
V+ L + +N + GN PL +A NG + + L+D GA VN +N+ G T L A
Sbjct: 221 VVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAA 280
Query: 196 CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 230
+ +E L+ GAD+N+ G LH + L
Sbjct: 281 ASTHGALCLELLVGNGADVNMKSKDGKTPLHMTAL 315
Score = 97.1 bits (240), Expect = 7e-20
Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 1/189 (0%)
Query: 46 GASATKHDSEGKTAFHLAAAKGH-VECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHEC 104
GA + + +G T H AAA H CL +++ +G DV + G + LH+ A +
Sbjct: 262 GAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSR 321
Query: 105 IRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQ 164
+ ++QS + D +G T LH AA G + L + + + G PL LA
Sbjct: 322 SQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAAL 381
Query: 165 NGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNA 224
+G S+ C LL G D+++ + GRT L A G+ + L+ GAD N D G +
Sbjct: 382 SGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441
Query: 225 LHYSKLSEN 233
LHY+ + N
Sbjct: 442 LHYAAANCN 450
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/247 (26%), Positives = 109/247 (44%), Gaps = 6/247 (2%)
Query: 9 LSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH 68
L ++ N ++K D R + +V LL GA T D + T H AA+ G
Sbjct: 159 LLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGM 218
Query: 69 VECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHY 128
+ ++ ++ GVD+ + G++ LH+A N + +L+ + G T LH+
Sbjct: 219 ISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHF 278
Query: 129 AAA--QGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 186
AAA G L +++L + + +N+K DG PL + +G ++ GA ++ +K
Sbjct: 279 AAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDK 337
Query: 187 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 246
+G T L +A G + LI GAD G LH + LS G +S
Sbjct: 338 NGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALS---GFSDCCRKLLSS 394
Query: 247 DADLKTP 253
D+ TP
Sbjct: 395 GFDIDTP 401
Score = 94.7 bits (234), Expect = 4e-19
Identities = 66/234 (28%), Positives = 105/234 (44%), Gaps = 8/234 (3%)
Query: 29 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD---VTAQ 85
A G E V L+ + + K +T H AA GH ECLR++I + V Q
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 649
Query: 86 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHK 145
D G + L L+ N H +C+ LL ++ D G+TALH A G + V L +H
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 709
Query: 146 SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSR----NKSGRTALMLACEIGSS 201
+ L+D G P+ L+ GH + LL A +++ + G TAL AC G
Sbjct: 710 AKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHE 769
Query: 202 NAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTK 255
VE L+++ + ++ LH + +++N G +L+ + T +K
Sbjct: 770 TCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSK 822
Score = 89.4 bits (220), Expect = 2e-17
Identities = 59/195 (30%), Positives = 85/195 (43%)
Query: 41 LLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNS 100
LL GA +GKT H+ A G + +I G + +D G++ LH+AA+
Sbjct: 291 LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
Query: 101 HHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLL 160
H I L+ S G LH AA G + L I+ D G L
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLH 410
Query: 161 LAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL 220
A G+ E + LL+ GAD N ++K GR+ L A + + AL+ GA +N +D
Sbjct: 411 AAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470
Query: 221 GYNALHYSKLSENAG 235
G LHY+ S+ G
Sbjct: 471 GCTPLHYAATSDTDG 485
Score = 84.3 bits (207), Expect = 5e-16
Identities = 65/217 (29%), Positives = 112/217 (51%), Gaps = 13/217 (5%)
Query: 33 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 92
G AE + LG +AT DS+G+T H AA HVECL+++++H V + D+TG +
Sbjct: 802 GAAEMLIDTLGASIVNAT--DSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTP 859
Query: 93 LHLAAKNSHHECIRKLLQSKCPAESV-DSSGKTALHYAAAQGCLQAVQILCE---HKSPI 148
L +AA+N + L+ S ++ D+S TALH A ++G + ++ E ++ I
Sbjct: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI 919
Query: 149 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNA----- 203
N + PL +A +NG + + LL GA V + +++G T LAC A
Sbjct: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP-ALACAPNKDVADCLAL 978
Query: 204 VEALIKKGADLNLVDSLGYNALH-YSKLSENAGIQSL 239
+ A + + + + SL +NA++ Y+ S+ ++L
Sbjct: 979 ILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEAL 1015
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 113 bits (282), Expect = 1e-24
Identities = 67/207 (32%), Positives = 98/207 (47%)
Query: 37 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 96
KV LL K GAS G T H+AA GHV + ++ HG + G +ALH+A
Sbjct: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Query: 97 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 156
A++ E +R L+Q E+ +T LH +A G VQ L + + N G
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 157 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 216
PL L+ + GH ++ FLLDHGA ++ K G T L +A + G L++K A +
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Query: 217 VDSLGYNALHYSKLSENAGIQSLLLSK 243
G LH + +N + LLL +
Sbjct: 594 AGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Score = 108 bits (270), Expect = 2e-23
Identities = 66/218 (30%), Positives = 106/218 (48%), Gaps = 1/218 (0%)
Query: 29 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 88
A + G+A V LL + GA +G T H A GH + + +++ + ++
Sbjct: 275 ASKRGNANMVKLLLDR-GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333
Query: 89 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 148
G S LH+A + H C++ LLQ P + V + TALH AA G + ++L + K+
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393
Query: 149 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 208
N K L+G PL +A + ++ LL HGA + + +SG T + +A +G N V L+
Sbjct: 394 NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 453
Query: 209 KKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 246
GA N + G ALH + S A + L+ +Q
Sbjct: 454 HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491
Score = 101 bits (252), Expect = 3e-21
Identities = 67/236 (28%), Positives = 117/236 (49%), Gaps = 9/236 (3%)
Query: 17 NEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMI 76
++ KN D + A E + ++ +K + K S+ ++ AA GH+E I
Sbjct: 6 SQLKKNRDLEINAEEEPEKKRKH----RKRSRDRKKKSDANASYLRAARAGHLEKALDYI 61
Query: 77 THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQ 136
+GVD+ + G +ALHLA+K H E + +LLQ + ++ G TALH A+ G +
Sbjct: 62 KNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAE 121
Query: 137 AVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 196
V++L + + +N + +G PL +A Q H E+ FLLD+GA + + G T L +A
Sbjct: 122 VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL 181
Query: 197 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 252
+ G V L++ + + ALH + ++ +LLL +AD+++
Sbjct: 182 QQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVES 232
Score = 100 bits (250), Expect = 5e-21
Identities = 86/373 (23%), Positives = 163/373 (43%), Gaps = 34/373 (9%)
Query: 37 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 96
KVA +L K A+ G T H+A K ++ + +++ HG + A +G + +H+A
Sbjct: 381 KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVA 440
Query: 97 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 156
A H + +L+ + + G+TALH AA G + V+ L + + + K D
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ 500
Query: 157 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 216
PL ++ + G ++I LL GA N+ SG T L L+ G + L+ GA L++
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
Query: 217 VDSLGYNALHYSKLSENAGIQSLLLSK-ISQDADLKTPTKP------KQHDQVSKISSER 269
G+ LH + + +LLL K S DA K+ P + +V+ + ++
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 270 SGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRL 329
+P A +P ++ + I +T L + A+ +++
Sbjct: 621 GASP--HAAAKNGYTPLHIAAKKNQMDIATTLLE-----------YGADANAV------- 660
Query: 330 SDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE----AEADL 385
T + + ++++ D++SLL + A++ L NK L + ++ AE +
Sbjct: 661 ---TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717
Query: 386 SFDSYHSTQTDLG 398
+ ++ QT +G
Sbjct: 718 NQGAHVDAQTKMG 730
Score = 100 bits (249), Expect = 7e-21
Identities = 64/235 (27%), Positives = 110/235 (46%), Gaps = 3/235 (1%)
Query: 21 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 80
KN L GD LL + ++ TA H+AA GH + +V++
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 81 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 140
+ A+ G + LH+A K + + + LL+ ++V SG T +H AA G + V
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451
Query: 141 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 200
L H + N ++ G L +A ++G +E+ +L+ GA V ++ K +T L ++ +G
Sbjct: 452 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGK 511
Query: 201 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTK 255
++ V+ L+++GA N + GY LH LS G + + + A L TK
Sbjct: 512 ADIVQQLLQQGASPNAATTSGYTPLH---LSAREGHEDVAAFLLDHGASLSITTK 563
Score = 100 bits (248), Expect = 9e-21
Identities = 71/270 (26%), Positives = 123/270 (45%), Gaps = 7/270 (2%)
Query: 27 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 86
L + D +KVA LL +GAS G T H+AA K ++ ++ +G D A
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 87 TTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKS 146
G +++HLAA+ H + + LL + SG T LH AA + + ++L +
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
Query: 147 PINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEA 206
++ + G PL + G+ +I +FLL H A VN++ K+G T L A + G ++ +
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
Query: 207 LIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQH-----DQ 261
L++ A N + G AL ++ + L KI + + T T ++H +
Sbjct: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTL--KIVTEETMTTTTVTEKHKMNVPET 839
Query: 262 VSKISSERSGTPKKRKAPPPPISPTQLSDV 291
++++ +K AP +SDV
Sbjct: 840 MNEVLDMSDDEVRKANAPEMLSDGEYISDV 869
Score = 97.8 bits (242), Expect = 4e-20
Identities = 63/223 (28%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 33 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 92
G A+ V LL ++GAS + G T HL+A +GH + ++ HG ++ G +
Sbjct: 510 GKADIVQQLL-QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
Query: 93 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 152
LH+AAK E LLQ ++ SG T LH AA + +L + + +
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 153 LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 212
+G PL +A + +I LL++GAD N+ + G ++ LA + G + V L+ + A
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
Query: 213 DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTK 255
++NL + G LH + + + +L ++Q A + TK
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVL---VNQGAHVDAQTK 728
Score = 97.8 bits (242), Expect = 4e-20
Identities = 61/214 (28%), Positives = 102/214 (47%)
Query: 37 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 96
+VA+LL +K AS G T H+AA + + +++ G A G++ LH+A
Sbjct: 579 EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
Query: 97 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 156
AK + + LL+ A +V G ++H AA +G + V +L + +NL + G
Sbjct: 639 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698
Query: 157 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 216
PL LA Q + L++ GA V+++ K G T L + C G+ V L++ A +N
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
Query: 217 VDSLGYNALHYSKLSENAGIQSLLLSKISQDADL 250
GY LH + + I ++LL + +L
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
Score = 94.0 bits (232), Expect = 6e-19
Identities = 56/204 (27%), Positives = 97/204 (47%)
Query: 38 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAA 97
VA+LL + A+ T H+A+ +G+ +++++ G + A+ G + LH A
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGA 309
Query: 98 KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNI 157
++ H + + LL P S +G + LH A L VQ+L +H P++ D
Sbjct: 310 RSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLT 369
Query: 158 PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLV 217
L +A GH ++ LLD A+ N++ +G T L +AC+ +E L+K GA + V
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 218 DSLGYNALHYSKLSENAGIQSLLL 241
G +H + + I S L+
Sbjct: 430 TESGLTPIHVAAFMGHVNIVSQLM 453
Score = 93.2 bits (230), Expect = 1e-18
Identities = 63/206 (30%), Positives = 93/206 (45%)
Query: 36 EKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 95
E VA+ L GAS + +G T H+AA G +E +++ A +G + LH+
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 96 AAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDG 155
AA + + LL + +G T LH AA + + L E+ + N G
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664
Query: 156 NIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLN 215
+ LA Q GH ++ LL A+VN NKSG T L LA + N E L+ +GA ++
Sbjct: 665 IASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD 724
Query: 216 LVDSLGYNALHYSKLSENAGIQSLLL 241
+GY LH N I + LL
Sbjct: 725 AQTKMGYTPLHVGCHYGNIKIVNFLL 750
Score = 92.8 bits (229), Expect = 1e-18
Identities = 60/214 (28%), Positives = 99/214 (46%), Gaps = 1/214 (0%)
Query: 36 EKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 95
E+V +L + A G + H+A H+ C+++++ H V V +ALH+
Sbjct: 314 EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHV 373
Query: 96 AAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDG 155
AA H++ + LL K + +G T LH A + ++ +++L +H + I G
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 156 NIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLN 215
P+ +A GH I L+ HGA N+ N G TAL +A G + V L++ GA +
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493
Query: 216 LVDSLGYNALHYS-KLSENAGIQSLLLSKISQDA 248
LH S +L + +Q LL S +A
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Score = 92.8 bits (229), Expect = 1e-18
Identities = 59/223 (26%), Positives = 102/223 (45%), Gaps = 1/223 (0%)
Query: 21 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 80
+ + L A +G AE V L+ + GA + +T H++A G + ++ ++ G
Sbjct: 465 RGETALHMAARSGQAEVVRYLV-QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA 523
Query: 81 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 140
A T+G++ LHL+A+ H + LL G T LH AA G L+ +
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583
Query: 141 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 200
L + + + G PL +A + ++ LLD GA ++ K+G T L +A +
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643
Query: 201 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 243
+ L++ GAD N V G ++H + + + SLLL +
Sbjct: 644 MDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Score = 78.6 bits (192), Expect = 3e-14
Identities = 55/238 (23%), Positives = 108/238 (45%), Gaps = 10/238 (4%)
Query: 9 LSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH 68
L +E + K + L +V +L GA+ G T ++AA + H
Sbjct: 93 LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
Query: 69 VECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKT---A 125
+E ++ ++ +G + G + L +A + H + + LL++ D+ GK A
Sbjct: 153 LEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN-------DTKGKVRLPA 205
Query: 126 LHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRN 185
LH AA + +A +L ++ + +++ G PL +A G+ + LL+ A V+
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
Query: 186 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 243
++ T L +A + G++N V+ L+ +GA ++ G LH S + + +LL +
Sbjct: 266 RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323
Score = 77.8 bits (190), Expect = 5e-14
Identities = 55/221 (24%), Positives = 104/221 (47%), Gaps = 11/221 (4%)
Query: 26 LLQAVENGDAEKVASLLGKKGASATKHDSEGKT---AFHLAAAKGHVECLRVMITHGVDV 82
L A++ G + V+ LL ++D++GK A H+AA K + +++ + +
Sbjct: 177 LAVALQQGHDQVVSLLL--------ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228
Query: 83 TAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILC 142
+ +G + LH+AA + LL + + T LH A+ +G V++L
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL 288
Query: 143 EHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 202
+ + I+ K DG PL ++GH ++ LLD A + S+ K+G + L +A + N
Sbjct: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Query: 203 AVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 243
V+ L++ ++ V + ALH + + + +LL K
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Score = 57.8 bits (138), Expect = 5e-08
Identities = 36/133 (27%), Positives = 55/133 (41%)
Query: 9 LSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH 68
L + N NK+ L D VA +L +GA G T H+ G+
Sbjct: 683 LLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGN 742
Query: 69 VECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHY 128
++ + ++ H V A+ G++ LH AA+ H I LLQ+ + +G TAL
Sbjct: 743 IKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI 802
Query: 129 AAAQGCLQAVQIL 141
A G + V L
Sbjct: 803 ARRLGYISVVDTL 815
Score = 49.3 bits (116), Expect = 2e-05
Identities = 119/580 (20%), Positives = 232/580 (40%), Gaps = 90/580 (15%)
Query: 313 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 372
PP S+ + +++DS G D++L+ + Q D Q K + L+ E + +
Sbjct: 2082 PPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHD-----QDK-SPLSDSGFETRSE 2135
Query: 373 LQAKSPKEAEADLSFDSYHS---------TQTDL-------GPSLGKPGETSPPDSKS-S 415
+P+ AE+ +H T+T++ PS G +T P + S
Sbjct: 2136 KTPSAPQSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPK 2195
Query: 416 PSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNT 475
PS L T + ++ E ++ Q + S E + ++ + + E T
Sbjct: 2196 PSPTFMELEPKPTTSSIK-----EKVKAFQMKASSEEDDHNRVLSKGMRVKEETHITTTT 2250
Query: 476 EISENS----SDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVT 531
+ +S S++++ET S ++ MK S + K EL
Sbjct: 2251 RMVYHSPPGGEGASERIEETMSVHD-IMKAFQSGRDPSK----------------ELAGL 2293
Query: 532 EEEINVLKQDL-QNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVI 590
E + + D+ ++A E S ++ EK +++ KL ER +I+ +E+ + + + +
Sbjct: 2294 FEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKL-ER----IIEVHIEKGNQAEPTEVIIR 2348
Query: 591 ENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSE 650
E + ++ ++ + LKD L + E + +E +E E
Sbjct: 2349 ETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLE 2408
Query: 651 LSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYS 710
S++ E ED R +A+ I ++ L L+ S +D LSE++ +
Sbjct: 2409 SSRVNTPVSQE-EDSRPS------SAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESY 2461
Query: 711 KVLNELTQLKQLVDAQKENSVSITEHL-QVITTLRTAAKEMEEKISNL-KEHLASK---- 764
+ ++ ++L + + S+T+H + L+ + K EKI+ K+ + SK
Sbjct: 2462 RFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYKD 2521
Query: 765 --EVEVAKLEKQLLEEKAAM----------TDAMVPRSSYEKLQSSLESEVSVLASKLKE 812
E V K+ K +K + AM R + ++L E + ++
Sbjct: 2522 VSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREK--LIYEDRVDR 2579
Query: 813 SVKEKEKVHSEVVQIRSEVSQVKREK-ENIQTLLKSKEQE 851
+VKE E + +EVSQ R+K E + L+S E++
Sbjct: 2580 TVKEAE-------EKLTEVSQFFRDKTEKLNDELQSPEKK 2612
Score = 42.4 bits (98), Expect = 0.002
Identities = 143/761 (18%), Positives = 275/761 (36%), Gaps = 134/761 (17%)
Query: 247 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAP--------------------PPPISPT 286
D L++P QHDQ S+ + K P PP I+ T
Sbjct: 2106 DTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPPVITET 2165
Query: 287 QLSDV-----------SSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTG 335
+ V P++ P+S K S F E K SSI+E
Sbjct: 2166 RTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQ----- 2220
Query: 336 ADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQT 395
+ SSE D HN+ L ++ K YHS
Sbjct: 2221 ----MKASSEEDD----------------HNRVLSKGMRVKEETHITTTTRM-VYHSPPG 2259
Query: 396 DLGPSLGKPGETSPPDSKSSPSVLIHSLGK---STTDNDVRIQQLQEILQDLQKRLESSE 452
G S + ++ +H + K S D + L E + + S
Sbjct: 2260 GEGAS-----------ERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKSAVSPDVHKSA 2308
Query: 453 AERKQLQVELQSR---RAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQM 509
AE E ++ + E + + E + ++ET+ E KE+ QK +
Sbjct: 2309 AETSAQHAEKDNQMKPKLERIIEVHIEKGNQAEPTEVIIRETKKHPE---KEMYVYQKDL 2365
Query: 510 KLGLVS-----PESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN-----KEKVREL 559
G ++ PE D + E EEE ++ L + LE S N +E R
Sbjct: 2366 SRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLESSRVNTPVSQEEDSRPS 2425
Query: 560 EEKLVEREKGTVIKPPVE---EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD 616
+L+ + +K + EY + + S EK L EK + + ++
Sbjct: 2426 SAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESYRFAEKMLLSEKLDVSHSD---TEE 2482
Query: 617 TLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKE-AQAELEDYRKRKSLEDVT 675
++ +S+ K + ++ K++ LS++YK+ ++ + K + + VT
Sbjct: 2483 SVTDHAGPPSSELQGSDKRSREKIATAPKKEI--LSKIYKDVSENGVGKVSKDEHFDKVT 2540
Query: 676 AEY----IHKAEHEKLMQLTNVSRAKAEDAL---SEMKSQYSKVLNELTQLKQLVDAQKE 728
+ + +H M+ T + + L + + +LT++ Q ++
Sbjct: 2541 VLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQFF---RD 2597
Query: 729 NSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP 788
+ + + LQ + E + + N KE+ +S+ + EK LL E A D V
Sbjct: 2598 KTEKLNDELQ--------SPEKKARPKNGKEY-SSQSPTSSSPEKVLLTELLASNDEWVK 2648
Query: 789 RSSY----EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTL 844
+ + + E S+ +S K + ++ + V+ + +SQ K + Q+
Sbjct: 2649 ARQHGPDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSK-APDGPQSG 2707
Query: 845 LKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSL 904
+ K+ +++ + KF+Q +A+S +ED+ K + V K++E+ +
Sbjct: 2708 FQLKQSKLSSIRLKFEQG--------THAKSKDMSQEDR-KSDGQSRIPVKKIQESKLPV 2758
Query: 905 SQLSYSTSSSKRQSQQLEALQQQVK-QLQNQLAECKKQHQE 944
Y + ++Q + ++ + V Q + + K +H +
Sbjct: 2759 ----YQVFAREKQQKAIDLPDESVSVQKDFMVLKTKDEHAQ 2795
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 113 bits (282), Expect = 1e-24
Identities = 67/214 (31%), Positives = 110/214 (51%), Gaps = 1/214 (0%)
Query: 28 QAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDT 87
+A E+G + + L+G G D EG TA HLAA +GH+ L+ ++ G+D+ Q+
Sbjct: 165 RAAEHGQLDALDFLVGS-GCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNA 223
Query: 88 TGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 147
G +ALH AA SH +C++ LL++ ++ + LHYAA G ++L
Sbjct: 224 EGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGC 283
Query: 148 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEAL 207
N+ D G PL LAV++ + L++ +DVN+ + +T L LA E + + L
Sbjct: 284 ANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADML 343
Query: 208 IKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 241
+ G DLNL D G AL + S + + +++
Sbjct: 344 LIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
Score = 95.1 bits (235), Expect = 3e-19
Identities = 56/188 (29%), Positives = 92/188 (48%), Gaps = 2/188 (1%)
Query: 56 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ--SKC 113
G A L+A GH+ L++++ G + + G + LH AA+ H + +++
Sbjct: 91 GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV 150
Query: 114 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHF 173
+ VD G+TA H AA G L A+ L N+KD +GN L LA GH +
Sbjct: 151 ALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQR 210
Query: 174 LLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSEN 233
L+D G D+ +N G TAL A + V+ L++ G+ +N + + LHY+ LS +
Sbjct: 211 LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 270
Query: 234 AGIQSLLL 241
+ +L+
Sbjct: 271 EDVSRVLI 278
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/224 (28%), Positives = 98/224 (43%), Gaps = 5/224 (2%)
Query: 37 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ--DTTGHSALH 94
++ +L GA +G T H AA KGHV L ++ DV D G +A H
Sbjct: 105 RILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 164
Query: 95 LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLD 154
AA++ + + L+ S C D G TALH AA +G + +Q L + + ++ +
Sbjct: 165 RAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE 224
Query: 155 GNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 214
G L A H + LL G+ VN+ + + L A GS + LI G
Sbjct: 225 GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284
Query: 215 NLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQ 258
N+VD G + LH L+ +L+ I+ D+D+ +Q
Sbjct: 285 NVVDHQGASPLH---LAVRHNFPALVRLLINSDSDVNAVDNRQQ 325
Score = 62.4 bits (150), Expect = 2e-09
Identities = 45/180 (25%), Positives = 74/180 (41%), Gaps = 10/180 (5%)
Query: 18 EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 77
E N L + G LL + G++ + + H AA G + RV+I
Sbjct: 220 EQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
Query: 78 HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 137
G D G S LHLA +++ +R L+ S +VD+ +T LH AA
Sbjct: 280 AGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDI 339
Query: 138 VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLL----------DHGADVNSRNKS 187
+L +NL+D G L +AV++ H + ++ DH +D + ++ S
Sbjct: 340 ADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLS 399
Score = 62.0 bits (149), Expect = 3e-09
Identities = 43/146 (29%), Positives = 75/146 (51%), Gaps = 12/146 (8%)
Query: 93 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 152
LH AA+ ++ +++L+ + + + G+ ALH+AA G QAV++L EH++ ++ +D
Sbjct: 19 LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
Query: 153 LDGNI----------PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 202
G + LLL+ GH I L++ GA ++ +K G T L A + G
Sbjct: 79 AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
Query: 203 AVEALIKKGADLNL--VDSLGYNALH 226
+ +++ D+ L VD LG A H
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFH 164
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 112 bits (280), Expect = 2e-24
Identities = 147/675 (21%), Positives = 297/675 (44%), Gaps = 133/675 (19%)
Query: 364 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 423
L K+ Q K Q K+ + D+ +H D + K GE + K + + +L
Sbjct: 777 LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESK-GEMKKENMKKDEA--LKAL 833
Query: 424 GKSTTDNDVRIQQLQEILQ----DLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISE 479
++ ++++QL L+ +L L E +++ + +L+ + E+ CL +
Sbjct: 834 QNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
Query: 480 NSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLK 539
N S L+ET S+ ++ L Q+QM + E++ N E++++ L+
Sbjct: 894 NHS-----LQET-SEQNVILQHTLQQQQQM----LQQETIRNGELEDTQTKLEKQVSKLE 943
Query: 540 QDLQNALEESERNKEKVRELEEKL--------VEREK-----GTV--IKPPVEEYEEM-- 582
Q+LQ ++ E + EK+R++EEK ++R+K GT +K +++Y+E
Sbjct: 944 QELQ---KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 1000
Query: 583 ---------------KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 627
K+ + S ++ + + EK A +E+ KL+ + ++++T EA
Sbjct: 1001 KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT-EAL 1059
Query: 628 DEAEDMKEAMNRMIDELN---KQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 684
+ E ++ + EL +Q+ EL + ++AQ LE+ K +++D+TAE
Sbjct: 1060 QKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE--KYTTIKDLTAE------- 1110
Query: 685 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ----KENSVSITEHLQVI 740
L E K + EL ++ Q + + K+ + +T HL +
Sbjct: 1111 -----------------LRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVT-HLDM- 1151
Query: 741 TTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLE 800
T+R EME+KI L+ L E+E+ + KQ+ S +KLQ++
Sbjct: 1152 -TIREHRGEMEQKIIKLEGTLEKSELELKECNKQI-------------ESLNDKLQNA-- 1195
Query: 801 SEVSVLASKLKESVKEKEKV----HSEVVQIRSEVSQVKREKENIQTLLKSKEQEV-NEL 855
KE ++EKE + E+ Q++ E+ + ++ + +++++K +EQ + +
Sbjct: 1196 ----------KEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQY 1245
Query: 856 LQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS------- 908
+ QE ++ S ++L E + +++ + +E+ +L L + QLS
Sbjct: 1246 KEAIDLGQELRLTREQVQNSHTELAEARHQQV-QAQREIERLSSELEDMKQLSKEKDAHG 1304
Query: 909 ----YSTSSSKRQSQQLEA-LQQQVKQLQNQLAECKK-QHQEVISVYRMHLLYAVQGQMD 962
+SK + LEA +Q ++K+L ++ K+ H E+IS H + +
Sbjct: 1305 NHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQ 1364
Query: 963 EDVQKVLKQILTMCK 977
+ + L + L K
Sbjct: 1365 KSSVQQLNEQLEKAK 1379
Score = 77.4 bits (189), Expect = 6e-14
Identities = 129/585 (22%), Positives = 263/585 (44%), Gaps = 72/585 (12%)
Query: 419 LIHSLGKSTTDNDVRIQQLQEILQDLQK-RLESSEAERKQLQVELQSRRAELVCLNNTEI 477
L L K N + Q ++ + E +++ K +E ++A V + +I
Sbjct: 234 LREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQI 293
Query: 478 SENSSDLSQK---LKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEE 534
+++S + L+E ++K E++ K V+ ++ L+ ++EE
Sbjct: 294 INLEAEVSAQDKVLREAENKLEQSQKMVIEKEQS-------------------LQESKEE 334
Query: 535 INVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI----KPPVEEYEEMKSSYCSVI 590
LK DL LE++++ K R+ E L E+ + K V E E + ++
Sbjct: 335 CIKLKVDL---LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEIL 391
Query: 591 E----NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 646
E N KE L E+ + E+ LK+ L+ Q+ +E ++ E ++ M E+
Sbjct: 392 ERNLTNCEKENKRLQERCGLYKSELEILKEKLR-QLKEENNNGKEKLR-IMAVKNSEVMA 449
Query: 647 QVSELSQLYKEAQAELED----YRKRKSLEDVTAEYIHK--AEHEKLMQLTNVSRAKAED 700
Q++E Q + ++ELE+ R + SL + E + A++E+L ++ + + E
Sbjct: 450 QLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERL----DLCQQEIES 505
Query: 701 ALSEMKSQYSKVLNELTQLKQLVDAQKENS-VSITEHLQVITTLRTAAKEMEEKISNLKE 759
+ E++S K++++L ++L + S ++ + + IS L+
Sbjct: 506 SRVELRS-LEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRI 564
Query: 760 HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESE-VSVLASKLKESVKEKE 818
LA KE E+ KL L + + + S SSLE+E V + ++ ESVK++
Sbjct: 565 KLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQN 624
Query: 819 KVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL-------LQKFQQAQEELAEMKR 871
+ H+ Q E ++ E ++T L E E ++L +FQ QEEL E
Sbjct: 625 Q-HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK-- 681
Query: 872 YAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQL 931
A +SSKLE + KK +++ +L+E + ++YS+ ++K + E +++ K +
Sbjct: 682 -ASNSSKLESEMTKKCSQLLTLEKQLEEKI-----VAYSSIAAKNAELEQELMEKNEK-I 734
Query: 932 QNQLAECKKQHQEVISVY----RMHLLYAVQGQMDEDVQKVLKQI 972
++ +H+++ + ++HL +M++ ++++ Q+
Sbjct: 735 RSLETNINTEHEKICLAFEKAKKIHL--EQHKEMEKQIERLEAQL 777
Score = 54.3 bits (129), Expect = 6e-07
Identities = 109/500 (21%), Positives = 198/500 (39%), Gaps = 100/500 (20%)
Query: 526 HELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLV----EREKGTVIKPPVEEYEE 581
HEL++TE + L ++L + + EKL+ G + P YE
Sbjct: 145 HELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSP---YEN 201
Query: 582 MKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL----------------------- 618
+ S + K + +F +EI L++ L
Sbjct: 202 VCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFES 261
Query: 619 ----------KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED---- 664
K M + A +A + + I L +VS ++ +EA+ +LE
Sbjct: 262 IHFELTQSRAKVSMLESAQQQAASV-PILEEQIINLEAEVSAQDKVLREAENKLEQSQKM 320
Query: 665 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAE--------DALSEMKSQYSKVLNE 715
K +SL++ E I K + + L Q RA+ + + LS+ QY K + E
Sbjct: 321 VIEKEQSLQESKEECI-KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAE 379
Query: 716 LTQLKQ---------LVDAQKENSVSITE----HLQVITTLRTAAKEMEEKISNLKEHLA 762
+ Q L + +KEN + E + + L+ ++++E+ +N KE L
Sbjct: 380 KLEKVQAEEEILERNLTNCEKENK-RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLR 438
Query: 763 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 822
V+ +++ QL E R S KL+S LE++ +L K + E ++
Sbjct: 439 IMAVKNSEVMAQLTES----------RQSILKLESELENKDEILRDKF-SLMNENRELKV 487
Query: 823 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 882
V + ++E E+ + L+S E+ +++L K ++ + + +Y SS +ED
Sbjct: 488 RVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK-RELFGFKSYLSKYQMSSFSNKED 546
Query: 883 KDKKINEMSK---------------EVTKLKEAL--NSLSQLSYSTSSSKRQSQQLEALQ 925
+ E +K E+ KL L N LSQ S T + ++S +L +L+
Sbjct: 547 RCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQ-SLITCNDSQESSKLSSLE 605
Query: 926 -QQVKQLQNQLAECKKQHQE 944
+ VK +Q+AE K +
Sbjct: 606 TEPVKLGGHQVAESVKDQNQ 625
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.122 0.315
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,990,745
Number of Sequences: 37866
Number of extensions: 1501684
Number of successful extensions: 29583
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 862
Number of HSP's successfully gapped in prelim test: 1625
Number of HSP's that attempted gapping in prelim test: 9968
Number of HSP's gapped (non-prelim): 10019
length of query: 983
length of database: 18,247,518
effective HSP length: 112
effective length of query: 871
effective length of database: 14,006,526
effective search space: 12199684146
effective search space used: 12199684146
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.