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Search of human proteins with 224809476
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
(972 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 1859 0.0
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 1855 0.0
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 1852 0.0
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 1852 0.0
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 1852 0.0
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 1778 0.0
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 352 1e-96
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 351 2e-96
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 286 7e-77
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 273 7e-73
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 139 1e-32
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 139 1e-32
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 139 2e-32
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 131 3e-30
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 131 3e-30
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 131 3e-30
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa... 127 7e-29
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 126 1e-28
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 124 4e-28
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa... 123 7e-28
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 117 4e-26
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 117 4e-26
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 117 5e-26
gi|38044112 restin isoform b [Homo sapiens] 117 7e-26
gi|4506751 restin isoform a [Homo sapiens] 117 7e-26
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 115 2e-25
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 114 6e-25
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 113 1e-24
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 113 1e-24
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 112 2e-24
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 1859 bits (4815), Expect = 0.0
Identities = 972/972 (100%), Positives = 972/972 (100%)
Query: 1 MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 60
MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC
Sbjct: 1 MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 60
Query: 61 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA 120
LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA
Sbjct: 61 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA 120
Query: 121 QGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTA 180
QGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTA
Sbjct: 121 QGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTA 180
Query: 181 LMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLK 240
LMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLK
Sbjct: 181 LMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLK 240
Query: 241 TPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFA 300
TPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFA
Sbjct: 241 TPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFA 300
Query: 301 EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD 360
EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD
Sbjct: 301 EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD 360
Query: 361 KLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDND 420
KLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDND
Sbjct: 361 KLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDND 420
Query: 421 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKET 480
VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKET
Sbjct: 421 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKET 480
Query: 481 QSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESER 540
QSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESER
Sbjct: 481 QSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESER 540
Query: 541 NKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEI 600
NKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEI
Sbjct: 541 NKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEI 600
Query: 601 MKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSL 660
MKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSL
Sbjct: 601 MKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSL 660
Query: 661 EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV 720
EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV
Sbjct: 661 EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV 720
Query: 721 SITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSS 780
SITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSS
Sbjct: 721 SITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSS 780
Query: 781 YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQE 840
YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQE
Sbjct: 781 YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQE 840
Query: 841 VNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYST 900
VNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYST
Sbjct: 841 VNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYST 900
Query: 901 SSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQ 960
SSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQ
Sbjct: 901 SSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQ 960
Query: 961 ILTMCKNQSQKK 972
ILTMCKNQSQKK
Sbjct: 961 ILTMCKNQSQKK 972
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 1855 bits (4805), Expect = 0.0
Identities = 970/971 (99%), Positives = 970/971 (99%)
Query: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
E KTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL
Sbjct: 13 EKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 72
Query: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ
Sbjct: 73 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 132
Query: 122 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 181
GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL
Sbjct: 133 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 192
Query: 182 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 241
MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT
Sbjct: 193 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 252
Query: 242 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 301
PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE
Sbjct: 253 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 312
Query: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 361
PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK
Sbjct: 313 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 372
Query: 362 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 421
LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV
Sbjct: 373 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 432
Query: 422 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 481
RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ
Sbjct: 433 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 492
Query: 482 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 541
SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN
Sbjct: 493 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 552
Query: 542 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 601
KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM
Sbjct: 553 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 612
Query: 602 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 661
KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE
Sbjct: 613 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 672
Query: 662 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 721
DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS
Sbjct: 673 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 732
Query: 722 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 781
ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY
Sbjct: 733 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 792
Query: 782 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 841
EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV
Sbjct: 793 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 852
Query: 842 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 901
NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS
Sbjct: 853 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 912
Query: 902 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 961
SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI
Sbjct: 913 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 972
Query: 962 LTMCKNQSQKK 972
LTMCKNQSQKK
Sbjct: 973 LTMCKNQSQKK 983
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1852 bits (4797), Expect = 0.0
Identities = 968/971 (99%), Positives = 970/971 (99%)
Query: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
++ TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL
Sbjct: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
Query: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ
Sbjct: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
Query: 122 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 181
GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL
Sbjct: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
Query: 182 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 241
MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT
Sbjct: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
Query: 242 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 301
PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE
Sbjct: 250 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 309
Query: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 361
PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK
Sbjct: 310 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 369
Query: 362 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 421
LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV
Sbjct: 370 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 429
Query: 422 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 481
RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ
Sbjct: 430 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 489
Query: 482 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 541
SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN
Sbjct: 490 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 549
Query: 542 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 601
KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM
Sbjct: 550 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 609
Query: 602 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 661
KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE
Sbjct: 610 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 669
Query: 662 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 721
DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS
Sbjct: 670 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 729
Query: 722 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 781
ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY
Sbjct: 730 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 789
Query: 782 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 841
EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV
Sbjct: 790 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 849
Query: 842 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 901
NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS
Sbjct: 850 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 909
Query: 902 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 961
SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI
Sbjct: 910 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 969
Query: 962 LTMCKNQSQKK 972
LTMCKNQSQKK
Sbjct: 970 LTMCKNQSQKK 980
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1852 bits (4797), Expect = 0.0
Identities = 968/971 (99%), Positives = 970/971 (99%)
Query: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
++ TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL
Sbjct: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
Query: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ
Sbjct: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
Query: 122 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 181
GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL
Sbjct: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
Query: 182 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 241
MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT
Sbjct: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
Query: 242 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 301
PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE
Sbjct: 250 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 309
Query: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 361
PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK
Sbjct: 310 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 369
Query: 362 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 421
LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV
Sbjct: 370 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 429
Query: 422 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 481
RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ
Sbjct: 430 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 489
Query: 482 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 541
SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN
Sbjct: 490 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 549
Query: 542 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 601
KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM
Sbjct: 550 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 609
Query: 602 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 661
KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE
Sbjct: 610 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 669
Query: 662 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 721
DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS
Sbjct: 670 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 729
Query: 722 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 781
ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY
Sbjct: 730 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 789
Query: 782 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 841
EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV
Sbjct: 790 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 849
Query: 842 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 901
NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS
Sbjct: 850 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 909
Query: 902 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 961
SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI
Sbjct: 910 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 969
Query: 962 LTMCKNQSQKK 972
LTMCKNQSQKK
Sbjct: 970 LTMCKNQSQKK 980
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1852 bits (4797), Expect = 0.0
Identities = 968/971 (99%), Positives = 970/971 (99%)
Query: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
++ TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL
Sbjct: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
Query: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ
Sbjct: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
Query: 122 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 181
GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL
Sbjct: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
Query: 182 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 241
MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT
Sbjct: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
Query: 242 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 301
PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE
Sbjct: 250 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 309
Query: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 361
PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK
Sbjct: 310 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 369
Query: 362 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 421
LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV
Sbjct: 370 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 429
Query: 422 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 481
RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ
Sbjct: 430 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 489
Query: 482 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 541
SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN
Sbjct: 490 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 549
Query: 542 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 601
KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM
Sbjct: 550 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 609
Query: 602 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 661
KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE
Sbjct: 610 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 669
Query: 662 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 721
DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS
Sbjct: 670 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 729
Query: 722 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 781
ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY
Sbjct: 730 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 789
Query: 782 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 841
EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV
Sbjct: 790 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 849
Query: 842 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 901
NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS
Sbjct: 850 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 909
Query: 902 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 961
SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI
Sbjct: 910 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 969
Query: 962 LTMCKNQSQKK 972
LTMCKNQSQKK
Sbjct: 970 LTMCKNQSQKK 980
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 1778 bits (4604), Expect = 0.0
Identities = 939/971 (96%), Positives = 941/971 (96%), Gaps = 29/971 (2%)
Query: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
++ TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL
Sbjct: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
Query: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ
Sbjct: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
Query: 122 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 181
GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL
Sbjct: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
Query: 182 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 241
MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT
Sbjct: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
Query: 242 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 301
PTKPKQ LSDVSSPRSITSTPLSGKESVFFAE
Sbjct: 250 PTKPKQ-----------------------------LSDVSSPRSITSTPLSGKESVFFAE 280
Query: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 361
PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK
Sbjct: 281 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 340
Query: 362 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 421
LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV
Sbjct: 341 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 400
Query: 422 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 481
RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ
Sbjct: 401 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 460
Query: 482 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 541
SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN
Sbjct: 461 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 520
Query: 542 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 601
KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM
Sbjct: 521 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 580
Query: 602 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 661
KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE
Sbjct: 581 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 640
Query: 662 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 721
DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS
Sbjct: 641 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 700
Query: 722 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 781
ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY
Sbjct: 701 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 760
Query: 782 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 841
EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV
Sbjct: 761 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 820
Query: 842 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 901
NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS
Sbjct: 821 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 880
Query: 902 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 961
SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI
Sbjct: 881 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 940
Query: 962 LTMCKNQSQKK 972
LTMCKNQSQKK
Sbjct: 941 LTMCKNQSQKK 951
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 352 bits (902), Expect = 1e-96
Identities = 297/1102 (26%), Positives = 517/1102 (46%), Gaps = 172/1102 (15%)
Query: 3 AKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 62
A +WNK DDRL++A E GD EKV S+L KKG + K D EG++ FH+ +KG++ECL
Sbjct: 26 AHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLN 85
Query: 63 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 122
++ HGVD+T DT G +ALHLAAK H C++KLLQ CP E D G+TALH AA
Sbjct: 86 AILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMAD 145
Query: 123 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 182
C ++Q+LC+H + +N KD+DG PL+LA Q IC L+D GADVNSR+K RTALM
Sbjct: 146 CPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALM 205
Query: 183 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP 242
L CE G +AVE LIK GAD++L+D+LG+++ +Y+++ +N I +LL
Sbjct: 206 LGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL------------- 252
Query: 243 TKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK--ESVFFA 300
K +SE + ++ P + L+ + ++ S + + +
Sbjct: 253 ----------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIE 302
Query: 301 EPPFKAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLTLH 354
K + I++ + L D G + ++ E++++ L SLL AK H
Sbjct: 303 NEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ---H 359
Query: 355 NKELQDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH- 410
+ L+ K+ K E+D L S+ S + + L K G+ DS+ +SP + H
Sbjct: 360 EESLRTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPAHM 417
Query: 411 -----------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE-- 457
SL T+ ++ I L++ L+ ++ ES++ +R +LQ EL + AE
Sbjct: 418 QSRSMLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAECK 475
Query: 458 LVCLNNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESMDN 510
+ L + E+S + L LK+ Q + E+ +V +Q +K L S + N
Sbjct: 476 ALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGN 535
Query: 511 YSHFHELRVTEEEINV---------------------------------------LKQDL 531
+ EL+ +++ V L+++L
Sbjct: 536 HRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKEL 595
Query: 532 QNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFE 591
E E+ KV E+E + E + P E++E MKSS + + K+ +
Sbjct: 596 SMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMER 655
Query: 592 KYQEAQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYKEA 647
+++++ EI +LK + +K+++ Q +E E +K + + EL K+++EL+ +
Sbjct: 656 EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTL 715
Query: 648 QAELED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAEDAL 691
Q E+E Y K L++ +T E Y+ K H+ ++ N
Sbjct: 716 QKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 775
Query: 692 SEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 751
+E K + K+L E L + V + V +H + I L++ E+++++S LK+
Sbjct: 776 TEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCG 835
Query: 752 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 811
+ ++ L + K M++ VP ++E+++ +L ++ +L + K+ E ++
Sbjct: 836 EDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQ 895
Query: 812 EVVQIRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKFQQ 850
E V+I+ + +KR EN Q +K+ K Q+ N E+L +++
Sbjct: 896 EFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRK 955
Query: 851 AQEEL----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALNSL 893
QEE+ AE+K + ++ E+ ++K KE LK+ L+
Sbjct: 956 GQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLSEQ 1012
Query: 894 SQ-LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 952
+Q S S K+ Q+ + L++++ LQ L + + + + + H + + +
Sbjct: 1013 TQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRKTD 1066
Query: 953 DVQKVLK---QILTMCKNQSQK 971
++ K LK Q T KN +K
Sbjct: 1067 ELNKQLKDLSQKYTEVKNVKEK 1088
Score = 232 bits (591), Expect = 1e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 215 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 274
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 657 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 707
Query: 275 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 328
L + + + I L K E K ++ ++D D L
Sbjct: 708 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 767
Query: 329 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 384
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 768 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 821
Query: 385 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 444
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 822 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 869
Query: 445 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 504
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 870 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 924
Query: 505 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 560
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 925 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 977
Query: 561 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 611
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 978 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1037
Query: 612 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 659
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 1038 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
Query: 660 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 713
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1157
Query: 714 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 771
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1217
Query: 772 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 829
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 1218 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1277
Query: 830 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 889
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 1278 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1334
Query: 890 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 948
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 1335 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1394
Query: 949 QMDEDVQKVLKQILTM 964
MDEDVQ+ L QI+ M
Sbjct: 1395 HMDEDVQEALLQIIQM 1410
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 351 bits (901), Expect = 2e-96
Identities = 296/1098 (26%), Positives = 516/1098 (46%), Gaps = 172/1098 (15%)
Query: 7 EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 66
+WNK DDRL++A E GD EKV S+L KKG + K D EG++ FH+ +KG++ECL ++
Sbjct: 17 DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI 76
Query: 67 HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 126
HGVD+T DT G +ALHLAAK H C++KLLQ CP E D G+TALH AA C +
Sbjct: 77 HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSS 136
Query: 127 VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 186
+Q+LC+H + +N KD+DG PL+LA Q IC L+D GADVNSR+K RTALML CE
Sbjct: 137 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCE 196
Query: 187 IGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPK 246
G +AVE LIK GAD++L+D+LG+++ +Y+++ +N I +LL
Sbjct: 197 YGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL----------------- 239
Query: 247 QHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK--ESVFFAEPPF 304
K +SE + ++ P + L+ + ++ S + + +
Sbjct: 240 ------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDL 293
Query: 305 KAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLTLHNKEL 358
K + I++ + L D G + ++ E++++ L SLL AK H + L
Sbjct: 294 KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ---HEESL 350
Query: 359 QDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH----- 410
+ K+ K E+D L S+ S + + L K G+ DS+ +SP + H
Sbjct: 351 RTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPAHMQSRS 408
Query: 411 -------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE--LVCL 461
SL T+ ++ I L++ L+ ++ ES++ +R +LQ EL + AE + L
Sbjct: 409 MLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAL 466
Query: 462 NNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESMDNYSHF 514
+ E+S + L LK+ Q + E+ +V +Q +K L S + N+
Sbjct: 467 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 526
Query: 515 HELRVTEEEINV---------------------------------------LKQDLQNAL 535
EL+ +++ V L+++L
Sbjct: 527 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 586
Query: 536 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 595
E E+ KV E+E + E + P E++E MKSS + + K+ + ++++
Sbjct: 587 MEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEK 646
Query: 596 AQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL 651
+ EI +LK + +K+++ Q +E E +K + + EL K+++EL+ + Q E+
Sbjct: 647 SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI 706
Query: 652 ED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAEDALSEMK 695
E Y K L++ +T E Y+ K H+ ++ N +E K
Sbjct: 707 EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKK 766
Query: 696 SQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEV 755
+ K+L E L + V + V +H + I L++ E+++++S LK+ +
Sbjct: 767 LEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 826
Query: 756 EVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQ 815
++ L + K M++ VP ++E+++ +L ++ +L + K+ E ++ E V+
Sbjct: 827 KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVK 886
Query: 816 IRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKFQQAQEE 854
I+ + +KR EN Q +K+ K Q+ N E+L +++ QEE
Sbjct: 887 IKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEE 946
Query: 855 L----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALNSLSQ-L 896
+ AE+K + ++ E+ ++K KE LK+ L+ +Q
Sbjct: 947 IVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLSEQTQKY 1003
Query: 897 SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQK 956
S S K+ Q+ + L++++ LQ L + + + + + H + + +++ K
Sbjct: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRKTDELNK 1057
Query: 957 VLK---QILTMCKNQSQK 971
LK Q T KN +K
Sbjct: 1058 QLKDLSQKYTEVKNVKEK 1075
Score = 232 bits (591), Expect = 1e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 215 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 274
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 644 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 694
Query: 275 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 328
L + + + I L K E K ++ ++D D L
Sbjct: 695 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
Query: 329 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 384
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 755 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 808
Query: 385 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 444
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 809 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 856
Query: 445 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 504
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 857 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 911
Query: 505 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 560
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 912 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 964
Query: 561 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 611
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 965 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1024
Query: 612 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 659
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
Query: 660 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 713
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1144
Query: 714 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 771
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1204
Query: 772 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 829
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 1205 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1264
Query: 830 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 889
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 1265 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1321
Query: 890 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 948
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 1322 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1381
Query: 949 QMDEDVQKVLKQILTM 964
MDEDVQ+ L QI+ M
Sbjct: 1382 HMDEDVQEALLQIIQM 1397
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 286 bits (732), Expect = 7e-77
Identities = 271/1033 (26%), Positives = 458/1033 (44%), Gaps = 102/1033 (9%)
Query: 4 KTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRV 63
++ +W K+D+RLLQAVEN DA +VA+L+ +KG TK D EGK+AFHLAA +G CL V
Sbjct: 41 QSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEV 100
Query: 64 MITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGC 123
MI HG +V + D G++ALHLAAK H +C+++LLQ+ C + VDSSG TALH+AAA GC
Sbjct: 101 MIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGC 160
Query: 124 LQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALML 183
L ++LC K+ +N +D G PL++A Q H+++C LL GA N ++ GRTALML
Sbjct: 161 LSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALML 220
Query: 184 ACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPT 243
ACE S VE L++ GA + D+LG +A HY L+ + L+L + + A +P
Sbjct: 221 ACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGD----KLILHLLQEAAQRPSPP 276
Query: 244 KPKQHDQVSKISSERS-------GTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKES 296
D + SS+ S G PKKRKAPPPP S D + I
Sbjct: 277 SALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRL 336
Query: 297 VFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ-QDLLSLLQAKVASLTLHN 355
+ +I + ++K+R + A SL + + + Q LL Q + SL
Sbjct: 337 L--------QKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREV 388
Query: 356 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 415
+ LQ +L S E E + + + Q + G PG + SPS H L
Sbjct: 389 ESLQSRL---SLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEH-LASL 444
Query: 416 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN-----TEISENS 470
V +Q QE+++ +Q LE+ E + Q++VE + L ++ ++
Sbjct: 445 QEQVAVLTRQNQELMEKVQ-ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQH 503
Query: 471 SDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD 530
++ Q L++ +++ E +E + + G + ++ + + E ++N +
Sbjct: 504 AEALQALRQQETR-EVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNG-AET 561
Query: 531 LQNALEESERNKEKVRELEEKLVER-------EKGTVIKPPVEEYEEMKSSYCSVIENMN 583
+ E + + E E E K T KP E EM+++
Sbjct: 562 IDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETT--------- 612
Query: 584 KEKAFLFEKYQEAQEEIMKLK--DTLKSQMTQEASDEAE-------------------DM 622
+E+A + K AQ + + + + T+ ++EAE +M
Sbjct: 613 EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNM 672
Query: 623 KEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHE---KLMQL 679
+ +R + VS +A + L AE K + E ++ L
Sbjct: 673 EATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGL 732
Query: 680 TNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITTLR 733
R + +A +E+++ K + +L + +E S + Q+ L
Sbjct: 733 EEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALE 792
Query: 734 TAAKEMEEKISNLKE-HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEV 792
A +++ ++ S L+E AS ++ A+ + L EE+A A + + +L+ S E EV
Sbjct: 793 QAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEV 852
Query: 793 SVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQ 852
L+E + + +E+ + + E L + +E + L + ++A
Sbjct: 853 ------LREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREAS 906
Query: 853 EELAEMKRYAESSSKLEEDK----------DKKINEMSKEVTKLKEALNSLSQLSYSTSS 902
E L + A +L+E+ ++++ KE +L+ L S + S
Sbjct: 907 EALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSE 966
Query: 903 SKRQSQQLEALQQQVKQLQNQLAECKKQHQ----EVISVYRMHLLYAVQGQMDEDVQKVL 958
+R + LQ V QL+ QL E ++H+ EV V R L + E
Sbjct: 967 HER---IVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATA 1023
Query: 959 KQILTMCKNQSQK 971
+Q L + ++++
Sbjct: 1024 EQQLRGLRTEAER 1036
Score = 157 bits (397), Expect = 5e-38
Identities = 131/454 (28%), Positives = 222/454 (48%), Gaps = 39/454 (8%)
Query: 523 EINVLKQDLQNALEESERNKEKVRELEEKL-----VEREKGTVIKPPVEEYEEMKSSYCS 577
E+ + L+ AL + ER E ELE L E E G ++ V E E +S
Sbjct: 724 ELETRIRGLEEALRQRER--EAAAELEAALGKCEAAEAEAGR-LRERVREAEGSGASGGG 780
Query: 578 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQ 636
+ A ++A+E++ L+ A DEA + L +
Sbjct: 781 GGDTTQLRAAL-----EQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
Query: 637 VSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKS 696
+++ + E ELE R++ + T E A E +R AE ++E+ +
Sbjct: 836 LAQREEARLEQSRELEVLREQLATARATGEQQRTAAAE-----LGRARDAAEARVAELPA 890
Query: 697 QYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE 756
+ L +L++ +A +++ V +EH + L+ A E+ + ++L++ + + E
Sbjct: 891 ACEEARQGLAELREASEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGKE 946
Query: 757 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 816
A+L +L E+ V S +E++ +L++ V+ L +L+E + EK +EV Q+
Sbjct: 947 AARLRAELERERVCS----VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
Query: 817 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 876
+ E +K E+ + L + EQ++ L + ++A++ R E+ K +E KDKKI
Sbjct: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA---QSRAQEALDKAKE-KDKKI 1058
Query: 877 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 936
E+SKEV LKEAL + + ++EAL+ QVK LQ QL E + H V++
Sbjct: 1059 TELSKEVFNLKEALKE--------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
Query: 937 VYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 970
+YR HLLYA+QGQMDEDVQ++L QIL M + Q+Q
Sbjct: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
Score = 30.8 bits (68), Expect = 6.4
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 12/133 (9%)
Query: 423 IQQLQEILQDLQKRLESSEAERKQLQVE---LQSRR--AELVCLNNTEISENSSDLSQKL 477
+ QL+ L++L +R E + AE Q+Q E ++S R AE + +++
Sbjct: 978 VAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA 1037
Query: 478 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE--LRVTEEEINVLK---QDLQ 532
++ QS+ +EA+ + + +K K+ +S E + E + E+ L+ +DLQ
Sbjct: 1038 RQAQSRAQEALDK--AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ 1095
Query: 533 NALEESERNKEKV 545
L+E+ R+ V
Sbjct: 1096 QQLQEAARDHSSV 1108
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 273 bits (697), Expect = 7e-73
Identities = 254/1033 (24%), Positives = 463/1033 (44%), Gaps = 115/1033 (11%)
Query: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
+ WN++D +LL+AV GD +VA+L +K A TK DS G++ FHLAA+KG ECL
Sbjct: 11 QVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECL 70
Query: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
+++ +G D+ +++ G +ALHLA + +C++ LLQ ++VD+ ++ LH+AA+
Sbjct: 71 TILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASS 130
Query: 122 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 181
GC +V +LC+H++ +++ D DG PL++A GH+ IC LL GA VN +K+ ++AL
Sbjct: 131 GCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSAL 190
Query: 182 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 241
+LACE GS+ E L+ GAD VDS G++ALHY+ +++ + L +S+ +
Sbjct: 191 ILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRR--RG 248
Query: 242 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 301
+ QH ++ +S P + +A PP S + +E + E
Sbjct: 249 GQRLVQHPDLASQAS-----PSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYE 303
Query: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ--QDLLSLLQAKVASLTLHNKELQ 359
+ + +E + + T A + LD+ ++ + Q+L LL + + L+
Sbjct: 304 EERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLR 363
Query: 360 ---DKLQAKSPKE--AEADLSFDSYHSTQTDLGPSL--------------------GKPG 394
D ++ PK+ AE+ + P L +P
Sbjct: 364 PGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPE 423
Query: 395 ETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ-LQVELQS 453
E PP S +S ++ + T + Q D +L + + E Q L VE
Sbjct: 424 EQGPPQSPASETI------RKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGG 477
Query: 454 RRAELV--CLNNTEISENSSDLSQKLKETQS---------------------------KY 484
AE V N + + +L+ +E + K
Sbjct: 478 TVAEPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKM 537
Query: 485 EEAMKEVLSVQKQMKLGL-VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE 543
E ++ VL+ + K GL V PE S L+ I KQD EE E+
Sbjct: 538 EARLERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSI---KQD-----EEKEKRVP 589
Query: 544 KVR--ELEEKLVEREKGTVIKPPVE-EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEI 600
R L E+ G + K +E E ++ S +++E + + L + Q Q E+
Sbjct: 590 GARGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGE----LGRERQRLQREL 645
Query: 601 MKLKDTLKSQMT--QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRK 658
L L+ + EA + + +++++ + +EL + +L K ++ R
Sbjct: 646 QSLSQRLQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLW 705
Query: 659 SL--EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQK 716
D+ E +++ + ++ + D E + +++ E QL+ + +
Sbjct: 706 DCLPADLVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCR 765
Query: 717 ENSVSITEHLQ-VITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLE--EKAAMTD 773
E S+ + L ++EE++ ++ ++ K E+ KL++ L + E+ A
Sbjct: 766 EPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELR 825
Query: 774 AMVPRS--SYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ 831
A S +EK + SL ++ +LK +++ EV ++R V++ +R ++
Sbjct: 826 AREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLA 885
Query: 832 TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALN 891
++ EQE +QA E +++ +++ L+E + I + K+KE L
Sbjct: 886 A--QAAEQE--------RQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLK 935
Query: 892 SLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMD 951
L QL S+++ A++ + +L QL + +K H+E+IS YR HLL A +G M+
Sbjct: 936 KLEQL----------SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYME 985
Query: 952 EDVQKVLKQILTM 964
+V +L QIL+M
Sbjct: 986 HEVYNILLQILSM 998
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 139 bits (350), Expect = 1e-32
Identities = 205/941 (21%), Positives = 384/941 (40%), Gaps = 116/941 (12%)
Query: 14 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 136 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINI 195
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
D + L A C LL+ D G TALHYA + L H
Sbjct: 196 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 255
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 256 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 315
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS-----------KISQDADLKTP 242
L+++ ++ D G A Y+ + IQ +L +Q+ P
Sbjct: 316 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 375
Query: 243 TKPKQHDQVSKISSERSGTPKK---RKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFF 299
K+ + K+ + G + + A + S+ P+ S K+ F
Sbjct: 376 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQD--SQSYGKKKDEMF 433
Query: 300 AEPPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA 349
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 434 GNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVA 493
Query: 350 -------SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 402
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 494 QYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERK 548
Query: 403 SSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCL 461
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 549 DLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---AL 605
Query: 462 NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELR 518
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 606 REKTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIR 655
Query: 519 VTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSV 578
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 656 QRELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY--- 708
Query: 579 IENMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDEL 633
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 709 --NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDET 763
Query: 634 NKQVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT- 680
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 764 WTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTI 823
Query: 681 -----------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSI 722
N + K + ++K ++ ++ E + + V+ K+N V
Sbjct: 824 NMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLH 883
Query: 723 TEHLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDA 774
E L + L K +EEK+ NLK H+ VE+ K++ K L+E+A
Sbjct: 884 QELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIE 943
Query: 775 MVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLL 834
+ +K Q+ E ++ L S+K+KE +V + S++K E++ T L
Sbjct: 944 KLEEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTEL 999
Query: 835 KSKEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 874
+ ++ L+ E++ + K+ A S+KL +K++
Sbjct: 1000 EEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1040
Score = 56.2 bits (134), Expect = 1e-07
Identities = 114/579 (19%), Positives = 237/579 (40%), Gaps = 95/579 (16%)
Query: 431 QDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK-------ETQSK 483
++ Q+RLE SE ++ Q ++ E+ N + + + L ++L + K
Sbjct: 405 EEKQERLERSENKQPQDSQSYGKKKDEM--FGNFMLKRDIAMLKEELYAIKNDSLRKEKK 462
Query: 484 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD---LQNALEESER 540
Y + +K + + + + E M ++ +++N LK + L + LE+ +
Sbjct: 463 YIQEIKSITEINANFEKSVRLNEEMIT----KKVAQYSQQLNDLKAENARLNSKLEKEKH 518
Query: 541 NKEKVRELEEKLVEREKGTVIKPPVEEYEEM-----------KSSYCSVIENMNKEKAFL 589
NKE++ E L + + EY E+ ++ S E M + L
Sbjct: 519 NKERLEAEVESLHSN-----LATAINEYNEILERKDLELVLWRADDVSRHETMGSNISQL 573
Query: 590 FEKYQEAQEEIMKLK---DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLY 644
+K + E++ K + +TLK ++ T++A E E++ + + ++ E+ Q++
Sbjct: 574 TDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMH 633
Query: 645 -----KEAQA--------------ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA 685
KE+Q+ ELE+ + LED E +K + N+ R
Sbjct: 634 PNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEI------VINIHRD 687
Query: 686 KAEDALSEMKSQYSK-VLNELTQLKQ-LVDAQKENSV----------SITEHLQVITTLR 733
E+ ++ + +K ++NE LK+ L+ +KE + + +HL+ +
Sbjct: 688 CLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSE 747
Query: 734 TAAKEMEEKISNLKEHLASK----EVEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSS 787
+ + NL E SK +VE+ EK K +++ ++ + K
Sbjct: 748 SPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRE 807
Query: 788 LESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQ--------VKREKENIQTLLKSKEQ 839
LE E + L+ ++ +E +++ K+ K+ L+ KE
Sbjct: 808 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEA 867
Query: 840 EVNE---LLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 896
++ L + + +EL M + E KLE+DK ++ T +++ + L ++
Sbjct: 868 VSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKV 927
Query: 897 -SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 934
Y + +R Q +E L++ Q Q AE +KQ +++
Sbjct: 928 QEYKSELDERAMQAIEKLEEIHLQKQ---AEYEKQLEQL 963
Score = 44.3 bits (103), Expect = 6e-04
Identities = 72/433 (16%), Positives = 176/433 (40%), Gaps = 61/433 (14%)
Query: 521 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 580
++ I++ QD+ E +R ++++++E + + + +E + ++
Sbjct: 320 QQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLK 379
Query: 581 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS-- 638
K K K E +K+ K + + + ++ ++ + DE+
Sbjct: 380 KRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLK 439
Query: 639 -ELSQLYKEAQAELEDY--RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMK 695
+++ L +E A D +++K ++++ + A EK ++L E+ +++
Sbjct: 440 RDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLN-------EEMITKKV 492
Query: 696 SQYSKVLNEL----TQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 751
+QYS+ LN+L +L ++ +K N + +E ++ +L +LA
Sbjct: 493 AQYSQQLNDLKAENARLNSKLEKEKHNK-----------------ERLEAEVESLHSNLA 535
Query: 752 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 811
+ E ++LE K + ++ R+ ++ S +S L K E +
Sbjct: 536 TAINEY----NEILERKDL--ELVLWRADDVSRHETMGSNISQLTDK-------NELLTE 582
Query: 812 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 871
+V + R + + +K + + L+ K + + +QAQ + EMK+ + E
Sbjct: 583 QVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQ 642
Query: 872 KDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------------EALQQQV 917
K N S+E + +E N L + + + ++++ + L+++
Sbjct: 643 SIGKQNS-SEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 701
Query: 918 KQLQNQLAECKKQ 930
K+L N+ K++
Sbjct: 702 KELMNEYNYLKEK 714
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 139 bits (350), Expect = 1e-32
Identities = 205/941 (21%), Positives = 384/941 (40%), Gaps = 116/941 (12%)
Query: 14 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 165 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINI 224
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
D + L A C LL+ D G TALHYA + L H
Sbjct: 225 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 284
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 285 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 344
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS-----------KISQDADLKTP 242
L+++ ++ D G A Y+ + IQ +L +Q+ P
Sbjct: 345 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 404
Query: 243 TKPKQHDQVSKISSERSGTPKK---RKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFF 299
K+ + K+ + G + + A + S+ P+ S K+ F
Sbjct: 405 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQD--SQSYGKKKDEMF 462
Query: 300 AEPPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA 349
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 463 GNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVA 522
Query: 350 -------SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 402
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 523 QYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERK 577
Query: 403 SSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCL 461
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 578 DLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---AL 634
Query: 462 NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELR 518
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 635 REKTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIR 684
Query: 519 VTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSV 578
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 685 QRELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY--- 737
Query: 579 IENMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDEL 633
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 738 --NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDET 792
Query: 634 NKQVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT- 680
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 793 WTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTI 852
Query: 681 -----------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSI 722
N + K + ++K ++ ++ E + + V+ K+N V
Sbjct: 853 NMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLH 912
Query: 723 TEHLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDA 774
E L + L K +EEK+ NLK H+ VE+ K++ K L+E+A
Sbjct: 913 QELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIE 972
Query: 775 MVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLL 834
+ +K Q+ E ++ L S+K+KE +V + S++K E++ T L
Sbjct: 973 KLEEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTEL 1028
Query: 835 KSKEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 874
+ ++ L+ E++ + K+ A S+KL +K++
Sbjct: 1029 EEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1069
Score = 56.2 bits (134), Expect = 1e-07
Identities = 114/579 (19%), Positives = 237/579 (40%), Gaps = 95/579 (16%)
Query: 431 QDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK-------ETQSK 483
++ Q+RLE SE ++ Q ++ E+ N + + + L ++L + K
Sbjct: 434 EEKQERLERSENKQPQDSQSYGKKKDEM--FGNFMLKRDIAMLKEELYAIKNDSLRKEKK 491
Query: 484 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD---LQNALEESER 540
Y + +K + + + + E M ++ +++N LK + L + LE+ +
Sbjct: 492 YIQEIKSITEINANFEKSVRLNEEMIT----KKVAQYSQQLNDLKAENARLNSKLEKEKH 547
Query: 541 NKEKVRELEEKLVEREKGTVIKPPVEEYEEM-----------KSSYCSVIENMNKEKAFL 589
NKE++ E L + + EY E+ ++ S E M + L
Sbjct: 548 NKERLEAEVESLHSN-----LATAINEYNEILERKDLELVLWRADDVSRHETMGSNISQL 602
Query: 590 FEKYQEAQEEIMKLK---DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLY 644
+K + E++ K + +TLK ++ T++A E E++ + + ++ E+ Q++
Sbjct: 603 TDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMH 662
Query: 645 -----KEAQA--------------ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA 685
KE+Q+ ELE+ + LED E +K + N+ R
Sbjct: 663 PNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEI------VINIHRD 716
Query: 686 KAEDALSEMKSQYSK-VLNELTQLKQ-LVDAQKENSV----------SITEHLQVITTLR 733
E+ ++ + +K ++NE LK+ L+ +KE + + +HL+ +
Sbjct: 717 CLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSE 776
Query: 734 TAAKEMEEKISNLKEHLASK----EVEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSS 787
+ + NL E SK +VE+ EK K +++ ++ + K
Sbjct: 777 SPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRE 836
Query: 788 LESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQ--------VKREKENIQTLLKSKEQ 839
LE E + L+ ++ +E +++ K+ K+ L+ KE
Sbjct: 837 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEA 896
Query: 840 EVNE---LLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 896
++ L + + +EL M + E KLE+DK ++ T +++ + L ++
Sbjct: 897 VSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKV 956
Query: 897 -SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 934
Y + +R Q +E L++ Q Q AE +KQ +++
Sbjct: 957 QEYKSELDERAMQAIEKLEEIHLQKQ---AEYEKQLEQL 992
Score = 44.3 bits (103), Expect = 6e-04
Identities = 72/433 (16%), Positives = 176/433 (40%), Gaps = 61/433 (14%)
Query: 521 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 580
++ I++ QD+ E +R ++++++E + + + +E + ++
Sbjct: 349 QQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLK 408
Query: 581 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS-- 638
K K K E +K+ K + + + ++ ++ + DE+
Sbjct: 409 KRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLK 468
Query: 639 -ELSQLYKEAQAELEDY--RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMK 695
+++ L +E A D +++K ++++ + A EK ++L E+ +++
Sbjct: 469 RDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLN-------EEMITKKV 521
Query: 696 SQYSKVLNEL----TQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 751
+QYS+ LN+L +L ++ +K N + +E ++ +L +LA
Sbjct: 522 AQYSQQLNDLKAENARLNSKLEKEKHNK-----------------ERLEAEVESLHSNLA 564
Query: 752 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 811
+ E ++LE K + ++ R+ ++ S +S L K E +
Sbjct: 565 TAINEY----NEILERKDL--ELVLWRADDVSRHETMGSNISQLTDK-------NELLTE 611
Query: 812 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 871
+V + R + + +K + + L+ K + + +QAQ + EMK+ + E
Sbjct: 612 QVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQ 671
Query: 872 KDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------------EALQQQV 917
K N S+E + +E N L + + + ++++ + L+++
Sbjct: 672 SIGKQNS-SEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 730
Query: 918 KQLQNQLAECKKQ 930
K+L N+ K++
Sbjct: 731 KELMNEYNYLKEK 743
>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1139
Score = 139 bits (349), Expect = 2e-32
Identities = 205/941 (21%), Positives = 384/941 (40%), Gaps = 116/941 (12%)
Query: 14 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 165 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDRKDRTVLHLACAHGRVQVVTLLLDRKCQINI 224
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
D + L A C LL+ D G TALHYA + L H
Sbjct: 225 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 284
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 285 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 344
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS-----------KISQDADLKTP 242
L+++ ++ D G A Y+ + IQ +L +Q+ P
Sbjct: 345 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 404
Query: 243 TKPKQHDQVSKISSERSGTPKK---RKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFF 299
K+ + K+ + G + + A + S+ P+ S K+ F
Sbjct: 405 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQD--SQSYGKKKDEMF 462
Query: 300 AEPPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA 349
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 463 GNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVA 522
Query: 350 -------SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 402
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 523 QYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERK 577
Query: 403 SSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCL 461
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 578 DLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---AL 634
Query: 462 NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELR 518
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 635 REKTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIR 684
Query: 519 VTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSV 578
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 685 QRELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY--- 737
Query: 579 IENMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDEL 633
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 738 --NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDET 792
Query: 634 NKQVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT- 680
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 793 WTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTI 852
Query: 681 -----------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSI 722
N + K + ++K ++ ++ E + + V+ K+N V
Sbjct: 853 NMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLH 912
Query: 723 TEHLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDA 774
E L + L K +EEK+ NLK H+ VE+ K++ K L+E+A
Sbjct: 913 QELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIE 972
Query: 775 MVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLL 834
+ +K Q+ E ++ L S+K+KE +V + S++K E++ T L
Sbjct: 973 KLEEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTEL 1028
Query: 835 KSKEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 874
+ ++ L+ E++ + K+ A S+KL +K++
Sbjct: 1029 EEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1069
Score = 56.2 bits (134), Expect = 1e-07
Identities = 114/579 (19%), Positives = 237/579 (40%), Gaps = 95/579 (16%)
Query: 431 QDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK-------ETQSK 483
++ Q+RLE SE ++ Q ++ E+ N + + + L ++L + K
Sbjct: 434 EEKQERLERSENKQPQDSQSYGKKKDEM--FGNFMLKRDIAMLKEELYAIKNDSLRKEKK 491
Query: 484 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD---LQNALEESER 540
Y + +K + + + + E M ++ +++N LK + L + LE+ +
Sbjct: 492 YIQEIKSITEINANFEKSVRLNEEMIT----KKVAQYSQQLNDLKAENARLNSKLEKEKH 547
Query: 541 NKEKVRELEEKLVEREKGTVIKPPVEEYEEM-----------KSSYCSVIENMNKEKAFL 589
NKE++ E L + + EY E+ ++ S E M + L
Sbjct: 548 NKERLEAEVESLHSN-----LATAINEYNEILERKDLELVLWRADDVSRHETMGSNISQL 602
Query: 590 FEKYQEAQEEIMKLK---DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLY 644
+K + E++ K + +TLK ++ T++A E E++ + + ++ E+ Q++
Sbjct: 603 TDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMH 662
Query: 645 -----KEAQA--------------ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA 685
KE+Q+ ELE+ + LED E +K + N+ R
Sbjct: 663 PNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEI------VINIHRD 716
Query: 686 KAEDALSEMKSQYSK-VLNELTQLKQ-LVDAQKENSV----------SITEHLQVITTLR 733
E+ ++ + +K ++NE LK+ L+ +KE + + +HL+ +
Sbjct: 717 CLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSE 776
Query: 734 TAAKEMEEKISNLKEHLASK----EVEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSS 787
+ + NL E SK +VE+ EK K +++ ++ + K
Sbjct: 777 SPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRE 836
Query: 788 LESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQ--------VKREKENIQTLLKSKEQ 839
LE E + L+ ++ +E +++ K+ K+ L+ KE
Sbjct: 837 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEA 896
Query: 840 EVNE---LLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 896
++ L + + +EL M + E KLE+DK ++ T +++ + L ++
Sbjct: 897 VSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKV 956
Query: 897 -SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 934
Y + +R Q +E L++ Q Q AE +KQ +++
Sbjct: 957 QEYKSELDERAMQAIEKLEEIHLQKQ---AEYEKQLEQL 992
Score = 44.3 bits (103), Expect = 6e-04
Identities = 72/433 (16%), Positives = 176/433 (40%), Gaps = 61/433 (14%)
Query: 521 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 580
++ I++ QD+ E +R ++++++E + + + +E + ++
Sbjct: 349 QQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLK 408
Query: 581 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS-- 638
K K K E +K+ K + + + ++ ++ + DE+
Sbjct: 409 KRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLK 468
Query: 639 -ELSQLYKEAQAELEDY--RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMK 695
+++ L +E A D +++K ++++ + A EK ++L E+ +++
Sbjct: 469 RDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLN-------EEMITKKV 521
Query: 696 SQYSKVLNEL----TQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 751
+QYS+ LN+L +L ++ +K N + +E ++ +L +LA
Sbjct: 522 AQYSQQLNDLKAENARLNSKLEKEKHNK-----------------ERLEAEVESLHSNLA 564
Query: 752 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 811
+ E ++LE K + ++ R+ ++ S +S L K E +
Sbjct: 565 TAINEY----NEILERKDL--ELVLWRADDVSRHETMGSNISQLTDK-------NELLTE 611
Query: 812 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 871
+V + R + + +K + + L+ K + + +QAQ + EMK+ + E
Sbjct: 612 QVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQ 671
Query: 872 KDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------------EALQQQV 917
K N S+E + +E N L + + + ++++ + L+++
Sbjct: 672 SIGKQNS-SEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 730
Query: 918 KQLQNQLAECKKQ 930
K+L N+ K++
Sbjct: 731 KELMNEYNYLKEK 743
>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 131 bits (330), Expect = 3e-30
Identities = 206/947 (21%), Positives = 393/947 (41%), Gaps = 91/947 (9%)
Query: 14 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 144 KIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDI 203
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
D + L A + C LL+ D G TALHYA + L H
Sbjct: 204 CDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSH 263
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 264 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 323
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-----------------SKISQD 236
L+++ ++ D G A Y+ S+ I+ +L + +
Sbjct: 324 TLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKP 383
Query: 237 ADLKTPTKPKQHDQVSKISSERSGTPKKR---KAPPPPISPTQLSDVSSPRSITSTPLSG 293
A+LK + + + K++SE +R K P S + D + ++
Sbjct: 384 ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAM 443
Query: 294 KESVFFA--------EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 345
+ +A E + EI SI E S + ++ + A L+ L+
Sbjct: 444 LKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMI-TKTVARYSQQLNDLK 502
Query: 346 AKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSP 405
A+ A L N EL+ + K EAE +S HS+ L ++ + E + K
Sbjct: 503 AENARL---NSELEKEKHNKERLEAEV----ESLHSS---LATAINEYNEI--VERKDLE 550
Query: 406 SVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL----VC 460
VL + S + I QL + + L +++ + + L+ +L+ R L +
Sbjct: 551 LVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLA 610
Query: 461 LNNTEISENSSDLSQKLKETQSKYEEA-MKEVLSVQKQMKL-GLVSPESMDNYSHFHELR 518
L + ++ + ++KE + + KE S+ KQ L + + ++N +L
Sbjct: 611 LGSVQLDLRQA--QHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLE 668
Query: 519 VTEEE-------INVLKQDLQNALEE--SERNKEKVRE---LEEKLVEREKGTVIKPP-V 565
+E IN+ + L+N E+ ERNKE ++E L+EKL++ EK + V
Sbjct: 669 DARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIV 728
Query: 566 EEYEEMKSSYC---SVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDM 622
E++E + S+ E+ + + E KL Q+ + ++ E+
Sbjct: 729 REFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKL-----FQVEIQPEEKHEEF 783
Query: 623 KEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLM--QLT 680
++ + +I LN ++ + +E + E Y+K ++T ++ +E
Sbjct: 784 RK-LFELISLLNYTADQIRKKNRELEEEATGYKK---CLEMTINMLNAFANEDFSCHGDL 839
Query: 681 NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITEHLQV------ITTLR 733
N + K + ++K +++ ++ E + + V+ K+N V E L + L
Sbjct: 840 NTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLE 899
Query: 734 TAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMVPRSSYEKLQSSLESE 791
K +EE++ NLK H+ VE+ KL+ K L+E+A + +K Q+ E +
Sbjct: 900 KDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQK-QAEYEKQ 958
Query: 792 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-KEQEVNELLQKFQQ 850
+ L S+K+KE +V + S++K E + T L+ KE +
Sbjct: 959 LEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSM 1015
Query: 851 AQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 897
+++ + K+ A S+KL +K + +S T+ + L + L+
Sbjct: 1016 SKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLN 1062
Score = 45.1 bits (105), Expect = 3e-04
Identities = 78/395 (19%), Positives = 156/395 (39%), Gaps = 86/395 (21%)
Query: 613 QEASDEA--EDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHK 670
Q A D A D++ ++++ NK + + + A ++ +K E AE+ K
Sbjct: 341 QTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLK 400
Query: 671 -AEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-----ELTQLKQLVDAQKENSV---- 720
A EK +L + +D+ S K + + N ++ LK+ + A K +S+
Sbjct: 401 VASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 460
Query: 721 -------SITE-HLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 772
SITE + ++R K + + ++ + L + E A+L +L +EK
Sbjct: 461 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK---- 516
Query: 773 DAMVPRSSYEKLQSSLESEVSVLASKLKE------------------SVKEKEKVHSEVV 814
+ E+L++ +ES S LA+ + E V EK+ S +
Sbjct: 517 ------HNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNIS 570
Query: 815 QIRSE----VSQVKREKENIQTLLKSKEQEVNELLQK-----------FQQAQEELAEMK 859
Q+ + QV + + TL K K +E + L++ +QAQ + EMK
Sbjct: 571 QLTDKNELLTEQVHKARVKFNTL-KGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMK 629
Query: 860 RYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------- 910
+ + E K N + + + + +E N L + + + ++++
Sbjct: 630 QMHPNGEAKESQSIGKQNSLEERI-RQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 688
Query: 911 ------------EALQQQVKQLQNQLAECKKQHQE 933
+ L ++ L+ +L +C+K+ E
Sbjct: 689 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAE 723
>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1002
Score = 131 bits (330), Expect = 3e-30
Identities = 202/924 (21%), Positives = 385/924 (41%), Gaps = 91/924 (9%)
Query: 14 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 37 KIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDI 96
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
D + L A + C LL+ D G TALHYA + L H
Sbjct: 97 CDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSH 156
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 157 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 216
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-----------------SKISQD 236
L+++ ++ D G A Y+ S+ I+ +L + +
Sbjct: 217 TLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKP 276
Query: 237 ADLKTPTKPKQHDQVSKISSERSGTPKKR---KAPPPPISPTQLSDVSSPRSITSTPLSG 293
A+LK + + + K++SE +R K P S + D + ++
Sbjct: 277 ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAM 336
Query: 294 KESVFFA--------EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 345
+ +A E + EI SI E S + ++ + A L+ L+
Sbjct: 337 LKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMI-TKTVARYSQQLNDLK 395
Query: 346 AKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSP 405
A+ A L N EL+ + K EAE +S HS+ L ++ + E + K
Sbjct: 396 AENARL---NSELEKEKHNKERLEAEV----ESLHSS---LATAINEYNEI--VERKDLE 443
Query: 406 SVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL----VC 460
VL + S + I QL + + L +++ + + L+ +L+ R L +
Sbjct: 444 LVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLA 503
Query: 461 LNNTEISENSSDLSQKLKETQSKYEEA-MKEVLSVQKQMKL-GLVSPESMDNYSHFHELR 518
L + ++ + ++KE + + KE S+ KQ L + + ++N +L
Sbjct: 504 LGSVQLDLRQA--QHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLE 561
Query: 519 VTEEE-------INVLKQDLQNALEE--SERNKEKVRE---LEEKLVEREKGTVIKPP-V 565
+E IN+ + L+N E+ ERNKE ++E L+EKL++ EK + V
Sbjct: 562 DARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIV 621
Query: 566 EEYEEMKSSYC---SVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDM 622
E++E + S+ E+ + + E KL Q+ + ++ E+
Sbjct: 622 REFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKL-----FQVEIQPEEKHEEF 676
Query: 623 KEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLM--QLT 680
++ + +I LN ++ + +E + E Y+K ++T ++ +E
Sbjct: 677 RK-LFELISLLNYTADQIRKKNRELEEEATGYKK---CLEMTINMLNAFANEDFSCHGDL 732
Query: 681 NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITEHLQV------ITTLR 733
N + K + ++K +++ ++ E + + V+ K+N V E L + L
Sbjct: 733 NTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLE 792
Query: 734 TAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMVPRSSYEKLQSSLESE 791
K +EE++ NLK H+ VE+ KL+ K L+E+A + +K Q+ E +
Sbjct: 793 KDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQK-QAEYEKQ 851
Query: 792 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-KEQEVNELLQKFQQ 850
+ L S+K+KE +V + S++K E + T L+ KE +
Sbjct: 852 LEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSM 908
Query: 851 AQEELAEMKRYAESSSKLEEDKDK 874
+++ + K+ A S+KL +K++
Sbjct: 909 SKKLMKSDKKIAVISTKLFMEKER 932
Score = 45.1 bits (105), Expect = 3e-04
Identities = 78/395 (19%), Positives = 156/395 (39%), Gaps = 86/395 (21%)
Query: 613 QEASDEA--EDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHK 670
Q A D A D++ ++++ NK + + + A ++ +K E AE+ K
Sbjct: 234 QTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLK 293
Query: 671 -AEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-----ELTQLKQLVDAQKENSV---- 720
A EK +L + +D+ S K + + N ++ LK+ + A K +S+
Sbjct: 294 VASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 353
Query: 721 -------SITE-HLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 772
SITE + ++R K + + ++ + L + E A+L +L +EK
Sbjct: 354 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK---- 409
Query: 773 DAMVPRSSYEKLQSSLESEVSVLASKLKE------------------SVKEKEKVHSEVV 814
+ E+L++ +ES S LA+ + E V EK+ S +
Sbjct: 410 ------HNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNIS 463
Query: 815 QIRSE----VSQVKREKENIQTLLKSKEQEVNELLQK-----------FQQAQEELAEMK 859
Q+ + QV + + TL K K +E + L++ +QAQ + EMK
Sbjct: 464 QLTDKNELLTEQVHKARVKFNTL-KGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMK 522
Query: 860 RYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------- 910
+ + E K N + + + + +E N L + + + ++++
Sbjct: 523 QMHPNGEAKESQSIGKQNSLEERI-RQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 581
Query: 911 ------------EALQQQVKQLQNQLAECKKQHQE 933
+ L ++ L+ +L +C+K+ E
Sbjct: 582 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAE 616
>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 131 bits (330), Expect = 3e-30
Identities = 206/947 (21%), Positives = 393/947 (41%), Gaps = 91/947 (9%)
Query: 14 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 144 KIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDI 203
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
D + L A + C LL+ D G TALHYA + L H
Sbjct: 204 CDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSH 263
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 264 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 323
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-----------------SKISQD 236
L+++ ++ D G A Y+ S+ I+ +L + +
Sbjct: 324 TLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKP 383
Query: 237 ADLKTPTKPKQHDQVSKISSERSGTPKKR---KAPPPPISPTQLSDVSSPRSITSTPLSG 293
A+LK + + + K++SE +R K P S + D + ++
Sbjct: 384 ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAM 443
Query: 294 KESVFFA--------EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 345
+ +A E + EI SI E S + ++ + A L+ L+
Sbjct: 444 LKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMI-TKTVARYSQQLNDLK 502
Query: 346 AKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSP 405
A+ A L N EL+ + K EAE +S HS+ L ++ + E + K
Sbjct: 503 AENARL---NSELEKEKHNKERLEAEV----ESLHSS---LATAINEYNEI--VERKDLE 550
Query: 406 SVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL----VC 460
VL + S + I QL + + L +++ + + L+ +L+ R L +
Sbjct: 551 LVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLA 610
Query: 461 LNNTEISENSSDLSQKLKETQSKYEEA-MKEVLSVQKQMKL-GLVSPESMDNYSHFHELR 518
L + ++ + ++KE + + KE S+ KQ L + + ++N +L
Sbjct: 611 LGSVQLDLRQA--QHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLE 668
Query: 519 VTEEE-------INVLKQDLQNALEE--SERNKEKVRE---LEEKLVEREKGTVIKPP-V 565
+E IN+ + L+N E+ ERNKE ++E L+EKL++ EK + V
Sbjct: 669 DARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIV 728
Query: 566 EEYEEMKSSYC---SVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDM 622
E++E + S+ E+ + + E KL Q+ + ++ E+
Sbjct: 729 REFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKL-----FQVEIQPEEKHEEF 783
Query: 623 KEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLM--QLT 680
++ + +I LN ++ + +E + E Y+K ++T ++ +E
Sbjct: 784 RK-LFELISLLNYTADQIRKKNRELEEEATGYKK---CLEMTINMLNAFANEDFSCHGDL 839
Query: 681 NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITEHLQV------ITTLR 733
N + K + ++K +++ ++ E + + V+ K+N V E L + L
Sbjct: 840 NTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLE 899
Query: 734 TAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMVPRSSYEKLQSSLESE 791
K +EE++ NLK H+ VE+ KL+ K L+E+A + +K Q+ E +
Sbjct: 900 KDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQK-QAEYEKQ 958
Query: 792 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-KEQEVNELLQKFQQ 850
+ L S+K+KE +V + S++K E + T L+ KE +
Sbjct: 959 LEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSM 1015
Query: 851 AQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 897
+++ + K+ A S+KL +K + +S T+ + L + L+
Sbjct: 1016 SKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLN 1062
Score = 45.1 bits (105), Expect = 3e-04
Identities = 78/395 (19%), Positives = 156/395 (39%), Gaps = 86/395 (21%)
Query: 613 QEASDEA--EDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHK 670
Q A D A D++ ++++ NK + + + A ++ +K E AE+ K
Sbjct: 341 QTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLK 400
Query: 671 -AEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-----ELTQLKQLVDAQKENSV---- 720
A EK +L + +D+ S K + + N ++ LK+ + A K +S+
Sbjct: 401 VASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 460
Query: 721 -------SITE-HLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 772
SITE + ++R K + + ++ + L + E A+L +L +EK
Sbjct: 461 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK---- 516
Query: 773 DAMVPRSSYEKLQSSLESEVSVLASKLKE------------------SVKEKEKVHSEVV 814
+ E+L++ +ES S LA+ + E V EK+ S +
Sbjct: 517 ------HNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNIS 570
Query: 815 QIRSE----VSQVKREKENIQTLLKSKEQEVNELLQK-----------FQQAQEELAEMK 859
Q+ + QV + + TL K K +E + L++ +QAQ + EMK
Sbjct: 571 QLTDKNELLTEQVHKARVKFNTL-KGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMK 629
Query: 860 RYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------- 910
+ + E K N + + + + +E N L + + + ++++
Sbjct: 630 QMHPNGEAKESQSIGKQNSLEERI-RQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 688
Query: 911 ------------EALQQQVKQLQNQLAECKKQHQE 933
+ L ++ L+ +L +C+K+ E
Sbjct: 689 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAE 723
>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
sapiens]
Length = 823
Score = 127 bits (318), Expect = 7e-29
Identities = 165/809 (20%), Positives = 321/809 (39%), Gaps = 104/809 (12%)
Query: 14 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ +A GDA +V L ++ D + +TA HLA A GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGELDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDV 95
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 234
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 235 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 294
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 295 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 354
S+ +P + E +++ R + T A+ L ++SE +QQ
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQQ----------RHERSE 379
Query: 355 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 406
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 407 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 465
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 466 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 510
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 WDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 511 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 552
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 553 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 607
V+ E+ + + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTQDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD-- 676
Query: 608 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 653
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNNLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 654 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLKQ 710
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK+
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDFVLEEKSKKLMNECDHLKE 794
Query: 711 LVDAQKENSVSITEHLQVITTLRTAAKEM 739
+ + + ++ +T+ K++
Sbjct: 795 SLFQYEREKTEVVVSIKEDKYFQTSRKKI 823
Score = 43.5 bits (101), Expect = 0.001
Identities = 59/317 (18%), Positives = 128/317 (40%), Gaps = 30/317 (9%)
Query: 616 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 675
S E ED A+ + N Q Q A E + +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQQRHERSEKKQPQVKEGNNTNKSE 395
Query: 676 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 735
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 736 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 787
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDEN 514
Query: 788 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 842
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 843 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 894
E ++QQ +L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 895 QLSYSTSSSKRQSQQLE 911
L + ++ S Q+E
Sbjct: 629 NLKLALERTQDVSVQVE 645
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
sapiens]
Length = 823
Score = 126 bits (316), Expect = 1e-28
Identities = 170/808 (21%), Positives = 319/808 (39%), Gaps = 108/808 (13%)
Query: 14 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ +A GDA +V L ++ D + +TA HLA A GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDV 95
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 234
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 235 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 294
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 295 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 354
S+ +P + E +++ R + T A+ L ++SE +Q+
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQE----------RHERSE 379
Query: 355 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 406
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 407 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 465
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 466 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 510
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 511 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 552
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 553 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 607
V+ E+ + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD-- 676
Query: 608 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 653
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 654 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLK- 709
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKE 794
Query: 710 ---QLVDAQKENSVSITEHLQVITTLRT 734
Q + E VSI E T+ +T
Sbjct: 795 SLFQYEREKTEGVVSIKEDKYFQTSRKT 822
Score = 43.1 bits (100), Expect = 0.001
Identities = 59/317 (18%), Positives = 128/317 (40%), Gaps = 30/317 (9%)
Query: 616 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 675
S E ED A+ + N Q Q A E ++ +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSE 395
Query: 676 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 735
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 736 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 787
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDEN 514
Query: 788 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 842
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 843 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 894
E ++QQ L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 895 QLSYSTSSSKRQSQQLE 911
L + ++ S Q+E
Sbjct: 629 NLKLALERTRDVSVQVE 645
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
sapiens]
Length = 823
Score = 124 bits (311), Expect = 4e-28
Identities = 168/798 (21%), Positives = 315/798 (39%), Gaps = 108/798 (13%)
Query: 14 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ +A GDA +V L ++ D + +TA HLA A GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDV 95
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 234
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 235 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 294
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 295 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 354
S+ +P + E +++ R + T A+ L ++SE +Q+
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQE----------RHERSE 379
Query: 355 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 406
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 407 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 465
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 466 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 510
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 511 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 552
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 553 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 607
V+ E+ + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD-- 676
Query: 608 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 653
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 654 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLK- 709
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKE 794
Query: 710 ---QLVDAQKENSVSITE 724
Q + E VSI E
Sbjct: 795 SLFQYEREKTEGVVSIKE 812
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/317 (18%), Positives = 129/317 (40%), Gaps = 30/317 (9%)
Query: 616 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 675
S E ED A+ + N Q Q A E ++ +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSE 395
Query: 676 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 735
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 736 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 787
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDEN 514
Query: 788 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 842
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 843 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 894
E ++QQ +L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 895 QLSYSTSSSKRQSQQLE 911
L + ++ S Q+E
Sbjct: 629 NLKLALERTRDVSVQVE 645
>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
sapiens]
Length = 823
Score = 123 bits (309), Expect = 7e-28
Identities = 169/808 (20%), Positives = 318/808 (39%), Gaps = 108/808 (13%)
Query: 14 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ +A GDA +V L ++ D + +TA HLA GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACTSGHVQVVTLLVNRKCQIDV 95
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 234
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 235 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 294
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 295 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 354
S+ +P + E +++ R + T A+ L ++SE +Q+
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQE----------RHERSE 379
Query: 355 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 406
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 407 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 465
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 466 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 510
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 WDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 511 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 552
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 553 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 607
V+ E+ + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKAENEFLTEQLSETQIKFNALKD-- 676
Query: 608 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 653
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 654 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLK- 709
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKE 794
Query: 710 ---QLVDAQKENSVSITEHLQVITTLRT 734
Q + E VSI E T+ +T
Sbjct: 795 SLFQYEREKTEGVVSIKEDKYFQTSRKT 822
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/317 (18%), Positives = 129/317 (40%), Gaps = 30/317 (9%)
Query: 616 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 675
S E ED A+ + N Q Q A E ++ +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSE 395
Query: 676 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 735
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 736 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 787
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDEN 514
Query: 788 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 842
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 843 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 894
E ++QQ +L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 895 QLSYSTSSSKRQSQQLE 911
L + ++ S Q+E
Sbjct: 629 NLKLALERTRDVSVQVE 645
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 117 bits (294), Expect = 4e-26
Identities = 154/733 (21%), Positives = 327/733 (44%), Gaps = 96/733 (13%)
Query: 312 RENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT--------LHNKELQDKLQ 363
R+ + L T + LD S A QQ+L S + +V L H ++Q+ Q
Sbjct: 1135 RDLGEELEALKTELEDTLD--STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 364 AKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRI 423
S E + + +L + + E + + VL+ G D++ +
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAK-QTLENERGELANEVKVLLQGKG----DSEHKR 1247
Query: 424 QQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLN---------NTEISENSSDLS 474
++++ LQ+LQ + E R +L ++ + EL + +++++++ S L
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 475 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEI--NVLKQ--- 529
+L++TQ +E ++ LS+ ++K + D + F E EEE N+ KQ
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLK------QVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361
Query: 530 ------DLQNALEESERNKEKVRELEEKLVEREKGTVIK--PPVEEYEEMKSSYCSVIEN 581
D++ +E+S E E++ KL + +G + V Y++++ + + +
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Query: 582 MN---------KEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKE------AM 626
++ ++ A EK Q+ ++++ + T+ ++ +E + +E ++
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL 1481
Query: 627 NRMIDELNKQVSELSQLYKEAQAELEDY---------------RKRKSLEDVTAEYIHKA 671
R ++E +Q +EL +L K+ + E+ED + +++LE E +
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541
Query: 672 EH-EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQL-----KQLVDAQKENSVSITEH 725
E E +Q T ++ + E L MK+Q+ + L + KQLV +E + +
Sbjct: 1542 EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE 1601
Query: 726 LQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQ 785
+ + A K++E + +L+ H+ S + KQL + +A M D M +L
Sbjct: 1602 RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM------RELD 1655
Query: 786 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELL 845
+ S +LA + KE+ K+ + + +E++Q++ E++ +R K Q + +++ +E+
Sbjct: 1656 DTRASREEILA-QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ---QERDELADEIA 1711
Query: 846 QKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKR 905
+ L E +R ++LEE+ +++ +LK+A + Q++ + +
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERS 1771
Query: 906 QSQQLEALQQQVKQLQNQLAECKKQHQE--VISVYRMHL--LYAVQGQMDEDVQKVLKQI 961
+Q+ E +QQ+++ QN+ + K Q E V S Y+ + L A Q++E + K+
Sbjct: 1772 HAQKNENARQQLER-QNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830
Query: 962 LTMCK--NQSQKK 972
CK +++KK
Sbjct: 1831 QAACKQVRRTEKK 1843
Score = 103 bits (256), Expect = 1e-21
Identities = 143/691 (20%), Positives = 304/691 (43%), Gaps = 106/691 (15%)
Query: 323 TGADSLLDISSE-----ADQQDLLSLLQAKVASL-------TLHNKELQDKLQAKSPKEA 370
T LL +S + A +++L+ + + ++A+ TL ++ + +KLQ + +A
Sbjct: 832 TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA 891
Query: 371 EADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQ--- 427
E +L ++ +L L K + H L + + R Q LQ
Sbjct: 892 ETELCAEA-----EELRARLTA--------KKQELEEICHDLEARVEEEEERCQHLQAEK 938
Query: 428 ----EILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI--SENSSDLSQKLKETQ 481
+ +Q+L+++LE E+ R++LQ+E + A+L L +I + + L+++ K +
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998
Query: 482 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 541
+ E + +++ K S+ + HE +T+ E + +++ Q E R
Sbjct: 999 DRIAEFTTNLTEEEEKSK-------SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 542 K---------EKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 592
K +++ EL+ ++ E +K + + EE + + +E +K +K
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAE------LKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 593 YQEAQEEIMKLKDTLKSQMT--QEASDEAEDMKEAMNRMIDELNKQV-SELSQLYKEAQA 649
+E + +I +L++ L+S+ +A + D+ E + + EL + S +Q ++
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 650 ELEDYRKRKSLEDVTAEY----------IHKAEHEKLMQLTNVSRAKA--EDALSEMKSQ 697
E E +K+LE+ + +A E QL R KA E A ++++
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 698 YSKVLNELTQL----------KQLVDAQ-KENSVSITEHLQVITTLRTAAKEMEEKISNL 746
++ NE+ L ++ V+AQ +E V E +V T L +++ ++ N+
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 747 KEHLASKEVEVAKLEKQL--LEEKAAMTDAMVPRSSYEKLQSS-----LESEVSVLASKL 799
L+ + + +KL K LE + T ++ + +KL S +E E + +L
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 800 KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQK-----FQQAQEE 854
+E + K + ++ + ++V+ +K++ E+ L++ E EV LQK Q+ +E+
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE-EVKRKLQKDLEGLSQRHEEK 1404
Query: 855 LAEMKRYAESSSKLEEDKDK---KINEMSKEVTKLKEALNSLSQL--SYSTSSSK----R 905
+A + ++ ++L+++ D ++ + L++ QL T S+K R
Sbjct: 1405 VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464
Query: 906 QSQQLEALQQQVK--QLQNQLAECKKQHQEV 934
+ EA +++ K L L E +Q E+
Sbjct: 1465 DRAEAEAREKETKALSLARALEEAMEQKAEL 1495
Score = 86.7 bits (213), Expect = 1e-16
Identities = 162/856 (18%), Positives = 338/856 (39%), Gaps = 151/856 (17%)
Query: 149 LLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDS 208
L ++ S+I D ++ SRNK+ + L E+ EAL + D +DS
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL------EALKTELEDT--LDS 1154
Query: 209 LGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAP 268
SK + I L + ++ + + ++H Q + +E+ K+ KA
Sbjct: 1155 TAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKAN 1214
Query: 269 PPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIR-----------ENKDR 317
T ++ + L GK +A++ ++ E D+
Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK 1274
Query: 318 LSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFD 377
++ D++ + S++D + S L ++L ++ Q+ LQ ++ ++
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKS--SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK 1332
Query: 378 SYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRL 437
+ L + E H+L K ++ +++ ++D L
Sbjct: 1333 QVEDEKNSFREQLEEEEEAK------------HNLEKQIATLHAQVADMKKKMEDSVGCL 1380
Query: 438 ESSEAERKQLQVELQ--SRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQ 495
E++E +++LQ +L+ S+R E ++ + + L Q+L + + + +++
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440
Query: 496 KQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEK-----VRELEE 550
K+ K F +L E+ I+ + ++ E R KE R LEE
Sbjct: 1441 KKQK-------------KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEE 1487
Query: 551 KLVER-EKGTVIKPPVEEYEEMKSSYCSV---IENMNKEKAFLFEKYQEAQEEIMKLKDT 606
+ ++ E + K E E++ SS V + + K K L ++ +E + ++ +L+D
Sbjct: 1488 AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE 1547
Query: 607 LKSQMTQEASDEAEDMKEAMNRMID--------ELNKQVSELSQLYKEAQAELEDYRKRK 658
L Q T++A E +AM + + ++ +L + +E +AELED RK++
Sbjct: 1548 L--QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605
Query: 659 S------------LEDVTA--EYIHKAEHEKLMQLTNV-------------SRAKAEDAL 691
S L+D+ A + +K E + QL + +RA E+ L
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 692 SEMKSQYSKVLN---ELTQLKQ----------------------LVDAQKENSVSITEHL 726
++ K K+ + E+ QL++ + ++ + ++++ E
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725
Query: 727 QVITTLRTAAKEMEEKISNL------------------------KEHLASKEVEVAKLEK 762
++ + +E+EE+ N + H E +LE+
Sbjct: 1726 RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER 1785
Query: 763 QLLEEKAAMTDAM-VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEV----VQIR 817
Q E K + + +S Y+ ++LE++++ L +L KE++ +V +++
Sbjct: 1786 QNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK 1845
Query: 818 SEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLE---EDKDK 874
+ QV E+ N + ++ L Q +Q +E E +R S KL+ ED +
Sbjct: 1846 DVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1905
Query: 875 KINEMSKEVTKLKEAL 890
+ M++EV+ LK L
Sbjct: 1906 TADAMNREVSSLKNKL 1921
Score = 81.3 bits (199), Expect = 4e-15
Identities = 105/586 (17%), Positives = 246/586 (41%), Gaps = 63/586 (10%)
Query: 306 AEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNK-------EL 358
A + + K RL D L+D+ + L Q K L K E
Sbjct: 1406 AAYDKLEKTKTRLQQELD--DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 359 QDKLQAKSPKEAEADLSF----DSYHSTQTDLGPSLGKPGETSPPD---SKSSPSVLIHS 411
+D+ +A++ ++ LS + + +L L K T D SK +H
Sbjct: 1464 RDRAEAEAREKETKALSLARALEEAMEQKAEL-ERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 412 LGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS 471
L KS + ++++++ L++L+ L+++E + +L+V LQ+ +A+ ++
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF----ERDLQGRDE 1578
Query: 472 DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDL 531
+K K+ + E E+ +KQ + + + + ++ +L+ E I+ ++
Sbjct: 1579 QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM-----DLKDLEAHIDSANKNR 1633
Query: 532 QNALEESER----NKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA 587
A+++ + K+ +REL++ RE+ ++ E +++KS +I+ + +E A
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREE--ILAQAKENEKKLKSMEAEMIQ-LQEELA 1690
Query: 588 FLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEA 647
++AQ+E +D L ++ + A ++E L ++++L + +E
Sbjct: 1691 AAERAKRQAQQE----RDELADEIANSSGKGALALEEKRR-----LEARIAQLEEELEEE 1741
Query: 648 QAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQ 707
Q E R ++ + I+ + L K E+A +++ Q ++ +L +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTD-----LNLERSHAQKNENARQQLERQNKELKVKLQE 1796
Query: 708 LKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEE 767
++ V ++ + S++ +E KI+ L+E L ++ E KQ+
Sbjct: 1797 MEGTVKSKYKASITA----------------LEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 768 KAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREK 827
+ + D ++ + + + +++LK+ ++ E+ E + + +++RE
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 828 ENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKD 873
E+ + +EV+ L K ++ +R A + D++
Sbjct: 1901 EDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEE 1946
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 117 bits (294), Expect = 4e-26
Identities = 105/399 (26%), Positives = 180/399 (45%), Gaps = 28/399 (7%)
Query: 3 AKTNEWNKNDDRL--LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 60
A+TNE + ND R+ + A + G + V LL K ++ + +G+ A +AA +GH +
Sbjct: 871 ARTNEID-NDGRIPFILASQEGHYDCVQILLENK-SNIDQRGYDGRNALRVAALEGHRDI 928
Query: 61 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA 120
+ ++ +HG DV +D G L++ A + L++ E+ D+ G+TALH +
Sbjct: 929 VELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCW 988
Query: 121 QGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTA 180
QG ++ VQ+L + + +N D + L A GH ++ L++HGA V+ G TA
Sbjct: 989 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 1048
Query: 181 LMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL--LSKISQDAD 238
L +A + G + V+ L++ GAD N D G A+ + + ++ I LL S +
Sbjct: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGC 1108
Query: 239 LKTPTKPKQHDQVSKISSE-RSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESV 297
+P + + +SS+ +S T K + Q S R + + P S
Sbjct: 1109 SPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQ----PSLRGLPNGPTHAFSS- 1163
Query: 298 FFAEPPFKAEISSIRENKDRLSDSTTGA---DSLLDISSEADQQDLLSLLQAKVASLTLH 354
P ++ S++ K LS+++ + SL SS A Q V + H
Sbjct: 1164 -----PSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQ--------TVPIDSFH 1210
Query: 355 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKP 393
N +++Q S + + S S ST LG S P
Sbjct: 1211 NLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSP 1249
Score = 117 bits (293), Expect = 5e-26
Identities = 70/209 (33%), Positives = 104/209 (49%), Gaps = 1/209 (0%)
Query: 9 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 68
N LL A G A V +LL GA+ DSEG+T +A+A+G+VE +R ++ G
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFW-GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
Query: 69 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 128
+D +D G + LH+AA H L++ +D+ G+ A+ +G VQ
Sbjct: 838 LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
Query: 129 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIG 188
IL E+KS I+ + DG L +A GH +I L HGADVN ++ GR L +
Sbjct: 898 ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
Query: 189 SSNAVEALIKKGADLNLVDSLGYNALHYS 217
E ++ GA++ D+ G ALH S
Sbjct: 958 QLTMAEYFLENGANVEASDAEGRTALHVS 986
Score = 112 bits (281), Expect = 1e-24
Identities = 75/233 (32%), Positives = 110/233 (47%), Gaps = 5/233 (2%)
Query: 3 AKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 62
A N+ + N LL + V +LL +GA D+ G T LAA +GH + +
Sbjct: 536 ASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVN 595
Query: 63 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 122
+I G ++ D G +AL AA H E + LL + + D+ +TAL AA G
Sbjct: 596 CLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGG 655
Query: 123 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 182
V L +H + +N D +G L+ A GH EI LLDHGA+VN + GRTAL
Sbjct: 656 HEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALS 715
Query: 183 LA-----CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 230
+A G ++ V LI +GA+++ D G L + + + LLL
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLL 768
Score = 110 bits (276), Expect = 5e-24
Identities = 81/247 (32%), Positives = 120/247 (48%), Gaps = 16/247 (6%)
Query: 9 NKNDDR----LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVM 64
N DDR + QA+E D+ + +LL GAS + DS G+T AA G ++ + ++
Sbjct: 508 NSEDDRTSCIVRQALEREDS--IRTLLDN-GASVNQCDSNGRTLLANAAYSGSLDVVNLL 564
Query: 65 ITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCL 124
++ G D+ +D GH+ L LAA+ H + + L+ D G TAL AA G
Sbjct: 565 VSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHT 624
Query: 125 QAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLA 184
+ V L ++ D D L A GH +I LL HGA+VN + GRTAL+ A
Sbjct: 625 EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAA 684
Query: 185 CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL-----SENAGIQSLLLSKISQ---- 235
+G VE L+ GA++N D G AL + L +A + SLL+ + ++
Sbjct: 685 AYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHC 744
Query: 236 DADLKTP 242
D D TP
Sbjct: 745 DKDGMTP 751
Score = 108 bits (271), Expect = 2e-23
Identities = 70/235 (29%), Positives = 112/235 (47%), Gaps = 5/235 (2%)
Query: 3 AKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 62
A N +++ L++ G +V S L G D++ +TA AA GH + +
Sbjct: 602 ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 661
Query: 63 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAA--- 119
++ HG +V D G +AL AA H E + LL D G+TAL AA
Sbjct: 662 NLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721
Query: 120 --AQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSG 177
++G V +L + + ++ D DG PLL+A GH ++ LL+ GADV+ + +G
Sbjct: 722 PASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNG 781
Query: 178 RTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 232
RT L+ A +G ++ V L+ GA ++ +DS G L + N + LL +
Sbjct: 782 RTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Score = 108 bits (271), Expect = 2e-23
Identities = 68/205 (33%), Positives = 100/205 (48%), Gaps = 5/205 (2%)
Query: 16 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 75
L+A G E + L + GA K D+EG+TA AA GH E + ++ HG +V +D
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707
Query: 76 TTGHSALHLAA-----KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQIL 130
G +AL +AA H + L+ + D G T L AA +G + V +L
Sbjct: 708 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 767
Query: 131 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSS 190
E + ++ D +G PLL A GH+ + + LL GA V+S + GRT L +A G+
Sbjct: 768 LEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNV 827
Query: 191 NAVEALIKKGADLNLVDSLGYNALH 215
V L+ +G D N D G+ LH
Sbjct: 828 EVVRTLLDRGLDENHRDDAGWTPLH 852
Score = 106 bits (264), Expect = 1e-22
Identities = 67/205 (32%), Positives = 103/205 (50%)
Query: 27 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAA 86
V SLL +GA D +G T +AA +GHV+ + +++ G DV D G + L AA
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
Query: 87 KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNI 146
H + LL +S+DS G+T L A+AQG ++ V+ L + N +D G
Sbjct: 790 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWT 849
Query: 147 PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLV 206
PL +A GH IC L++ GA N + GR +LA + G + V+ L++ ++++
Sbjct: 850 PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQR 909
Query: 207 DSLGYNALHYSKLSENAGIQSLLLS 231
G NAL + L + I LL S
Sbjct: 910 GYDGRNALRVAALEGHRDIVELLFS 934
Score = 104 bits (259), Expect = 5e-22
Identities = 63/213 (29%), Positives = 102/213 (47%), Gaps = 1/213 (0%)
Query: 18 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 77
A G+ E V +LL + G D G T H+AA +GH +I G D
Sbjct: 821 ASAQGNVEVVRTLLDR-GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 879
Query: 78 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 137
G LA++ H++C++ LL++K + G+ AL AA +G V++L H + +
Sbjct: 880 GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
Query: 138 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 197
N KD DG L + + + L++GA+V + + GRTAL ++C G V+ LI
Sbjct: 940 NCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLI 999
Query: 198 KKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 230
AD+N D+ +AL + + + LL+
Sbjct: 1000 AYHADVNAADNEKRSALQSAAWQGHVKVVQLLI 1032
Score = 102 bits (254), Expect = 2e-21
Identities = 66/201 (32%), Positives = 98/201 (48%), Gaps = 1/201 (0%)
Query: 15 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 74
LL A G + V LL + GA D+ G+T AA+ GH + ++ G V +
Sbjct: 752 LLVAAYEGHVD-VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
Query: 75 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHK 134
D+ G + L +A+ + E +R LL D +G T LH AA +G + L E
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 135 SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVE 194
+ N D DG IP +LA Q GH + LL++ ++++ R GR AL +A G + VE
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 195 ALIKKGADLNLVDSLGYNALH 215
L GAD+N D+ G L+
Sbjct: 931 LLFSHGADVNCKDADGRPTLY 951
Score = 92.8 bits (229), Expect = 1e-18
Identities = 66/207 (31%), Positives = 100/207 (48%), Gaps = 6/207 (2%)
Query: 9 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAA-----AKGHVECLRV 63
N+ L+ A G E V LL GA D +G+TA +AA +KGH + +
Sbjct: 675 NEGRTALIAAAYMGHREIVEHLLDH-GAEVNHEDVDGRTALSVAALCVPASKGHASVVSL 733
Query: 64 MITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGC 123
+I G +V D G + L +AA H + + LL+ + D++G+T L AA+ G
Sbjct: 734 LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGH 793
Query: 124 LQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALML 183
V L + ++ D +G L +A G+ E+ LLD G D N R+ +G T L +
Sbjct: 794 ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHM 853
Query: 184 ACEIGSSNAVEALIKKGADLNLVDSLG 210
A G EALI++GA N +D+ G
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDG 880
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 117 bits (293), Expect = 5e-26
Identities = 78/241 (32%), Positives = 113/241 (46%), Gaps = 4/241 (1%)
Query: 1 MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 60
+ AK N W L +AV + E V L+ K A D +T H+AAA V+C
Sbjct: 42 VNAKDNMWLTP---LHRAVASRSEEAVQVLI-KHSADVNARDKNWQTPLHVAAANKAVKC 97
Query: 61 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA 120
V+I V D G +ALH AA N H E + LL + D + ALH+AA
Sbjct: 98 AEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY 157
Query: 121 QGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTA 180
G L V +L H + + KD G PL A NG + LL+ G +++ N G TA
Sbjct: 158 MGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTA 217
Query: 181 LMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLK 240
L +AC G V LI GA++N ++ G+ LH++ S + + LL D +++
Sbjct: 218 LHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQ 277
Query: 241 T 241
+
Sbjct: 278 S 278
Score = 105 bits (263), Expect = 2e-22
Identities = 81/244 (33%), Positives = 125/244 (51%), Gaps = 12/244 (4%)
Query: 11 NDDRLLQAVENGDAEKVASL--LGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 68
N + L +A E + E L L + A+ + D EG + H AAA GH +CL +++
Sbjct: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 69 VDVTAQDTTG--HSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 126
+ +G S LHLAA N HH+ + LLQS + D G+TAL AA +G +
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
Query: 127 VQILCEHKSPINLKD-LDGNIPLLLAVQNGHSEICHFLL---DHGADVNSRNKSGRTALM 182
V+ L + I +KD + PL +V NGH+ LL D+ V+ ++ G+T LM
Sbjct: 591 VEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLM 650
Query: 183 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL----SKISQDAD 238
LA G +AV L++K A+++ VD LG ALH ++ + +LL S + +D+
Sbjct: 651 LAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR 710
Query: 239 LKTP 242
+TP
Sbjct: 711 GRTP 714
Score = 105 bits (261), Expect = 3e-22
Identities = 64/194 (32%), Positives = 95/194 (48%), Gaps = 1/194 (0%)
Query: 22 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 81
GDAE + LL GA D+ T H A A E ++V+I H DV A+D +
Sbjct: 27 GDAE-IIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTP 85
Query: 82 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 141
LH+AA N +C ++ D G+TALH+AA G ++ V +L + IN D
Sbjct: 86 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 145
Query: 142 LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 201
L A GH ++ L++HGA+V ++K G T L A G N V+ L+ G
Sbjct: 146 KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGV 205
Query: 202 DLNLVDSLGYNALH 215
+++ ++ G ALH
Sbjct: 206 EIDEINVYGNTALH 219
Score = 101 bits (251), Expect = 4e-21
Identities = 59/190 (31%), Positives = 95/190 (50%)
Query: 42 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 101
DSE +T H+AA G E + ++I G V A+D + LH A + E ++ L++
Sbjct: 13 DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
Query: 102 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 161
+ D + +T LH AAA ++ +++ S +N+ D G L A NGH E+ +
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN 132
Query: 162 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 221
LL GA++N+ +K R AL A +G + V LI GA++ D GY LH + +
Sbjct: 133 LLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192
Query: 222 NAGIQSLLLS 231
+ LL+
Sbjct: 193 QINVVKHLLN 202
Score = 100 bits (248), Expect = 9e-21
Identities = 78/247 (31%), Positives = 110/247 (44%), Gaps = 33/247 (13%)
Query: 16 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 75
L A G + LL GA K D G+T H AAA H C+ ++T G +V D
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443
Query: 76 TTGHSALHLAAK-----------NSHHE-----------------CIRKLLQSKCPAESV 107
G +ALH AA N+H C+ LLQ+
Sbjct: 444 DWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIR 503
Query: 108 DSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNI---PLLLAVQNGHSEICHFLL 164
D G ++HYAAA G Q +++L E ++ ++ D PL LA NGH + LL
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLE-RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLL 562
Query: 165 DHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNA-LHYSKLSENA 223
D++ R++ GRTAL LA G + VEALI GA + + D++ LH S ++ +
Sbjct: 563 QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHT 622
Query: 224 GIQSLLL 230
LLL
Sbjct: 623 LCLRLLL 629
Score = 96.7 bits (239), Expect = 1e-19
Identities = 66/219 (30%), Positives = 98/219 (44%), Gaps = 28/219 (12%)
Query: 42 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 101
D +G T H+AA GH + + T G D LHLAA N+H +C RKLL S
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG 370
Query: 102 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 161
++ D G+T LH AAA G ++ +++L + + KD G PL A N H
Sbjct: 371 FEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIE 430
Query: 162 FLLDHGADVNSRNKSGRTALMLAC----------------------------EIGSSNAV 193
L+ GA+VN + GRTAL A E ++ +
Sbjct: 431 TLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCL 490
Query: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 232
E L++ A+ ++ D GYN++HY+ + LLL +
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER 529
Score = 89.0 bits (219), Expect = 2e-17
Identities = 73/266 (27%), Positives = 112/266 (42%), Gaps = 35/266 (13%)
Query: 18 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH-VECLRVMITHGVDVTAQDT 76
A NG V L+ GA+ + ++ G T H AAA H CL +++ +G DV Q
Sbjct: 221 ACYNGQDAVVNELIDY-GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK 279
Query: 77 TGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 136
G S LH+ A + + L+Q+ + VD G T LH AA G + L +
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Query: 137 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIG-------- 188
+ PL LA N HS+ C LL G ++++ +K GRT L A G
Sbjct: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Query: 189 -SSNA------------------------VEALIKKGADLNLVDSLGYNALHYSKLSENA 223
SS A +E L+ GA++N D G ALHY+ S+
Sbjct: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMD 459
Query: 224 GIQSLLLSKISQDADLKTPTKPKQHD 249
+++L + +L+ + K+ +
Sbjct: 460 RNKTILGNAHDNSEELERARELKEKE 485
Score = 88.2 bits (217), Expect = 3e-17
Identities = 71/282 (25%), Positives = 110/282 (39%), Gaps = 67/282 (23%)
Query: 3 AKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 62
A N ++K D R L V +LL GA T D +G T H AA+ G + ++
Sbjct: 139 ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVK 198
Query: 63 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 122
++ GV++ + G++ALH+A N + +L+ +++G T LH+AAA
Sbjct: 199 HLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258
Query: 123 ----CLQAV------------------------------QILCEHKSPINLKDLDGNI-- 146
CL+ + Q L ++ I+ D DGN
Sbjct: 259 HGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPL 318
Query: 147 -------------------------------PLLLAVQNGHSEICHFLLDHGADVNSRNK 175
PL LA N HS+ C LL G ++++ +K
Sbjct: 319 HVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDK 378
Query: 176 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 217
GRT L A G+ ++ L GAD + D G LHY+
Sbjct: 379 FGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
Score = 85.9 bits (211), Expect = 2e-16
Identities = 66/243 (27%), Positives = 103/243 (42%), Gaps = 42/243 (17%)
Query: 42 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 101
D++G+T LA A GH++ + +++ +V D G +ALH H EC++ LL+ +
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
Query: 102 CPAESVDSSGKTALHYAAAQG---CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSE 158
DS G+T LHYAAA+G L + + + KD G PL A NG+
Sbjct: 702 VSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNEN 761
Query: 159 I----------------------CHFLLDHG------------ADVNSRNKSGRTALMLA 184
C + DHG + V+ R+ GRT L A
Sbjct: 762 CIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAA 821
Query: 185 CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS-----QDADL 239
++ L++ A +N VD+ G AL + + AG +L++ +D DL
Sbjct: 822 AFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDL 881
Query: 240 KTP 242
TP
Sbjct: 882 NTP 884
Score = 81.3 bits (199), Expect = 4e-15
Identities = 61/231 (26%), Positives = 99/231 (42%), Gaps = 39/231 (16%)
Query: 15 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV---DV 71
L + + G E V LL ++ + K DS G+T H AAA+GH L ++ + D
Sbjct: 682 LHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
Query: 72 TAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESV------------------------ 107
+D G++ LH A N + CI LL+ KC + +
Sbjct: 741 CFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLG 800
Query: 108 ----------DSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHS 157
D G+T L AA ++ +Q+L H +P+N D G L++A +NG +
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQA 860
Query: 158 EICHFLLDHG-ADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 207
L++ AD+ ++K T L LAC G ++ K D +L++
Sbjct: 861 GAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLIN 911
Score = 76.6 bits (187), Expect = 1e-13
Identities = 49/162 (30%), Positives = 79/162 (48%)
Query: 70 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 129
DV D+ + LH+AA E I L+ S + D+ T LH A A +AVQ+
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 130 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 189
L +H + +N +D + PL +A N + ++ + VN ++ GRTAL A G
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 190 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 231
V L+ KGA++N D ALH++ + + +LL++
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Score = 73.2 bits (178), Expect = 1e-12
Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 10/169 (5%)
Query: 18 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD---VTAQ 74
A NG+ + LL +K K T H A H C +++ +D V+ +
Sbjct: 754 ACYNGNENCIEVLLEQK--CFRKFIGNPFTPLHCAIINDHGNCASLLLG-AIDSSIVSCR 810
Query: 75 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH- 133
D G + L AA H EC++ LL+ P +VD+SGKTAL AA G AV IL
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD---VNSRNKSGRT 179
++ + +KD D N PL LA GH + +LD D +N +N + +T
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNALQT 919
Score = 66.2 bits (160), Expect = 1e-10
Identities = 41/127 (32%), Positives = 69/127 (54%)
Query: 106 SVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLD 165
++DS +T LH AA G + +++L + +N KD PL AV + E L+
Sbjct: 11 TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIK 70
Query: 166 HGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGI 225
H ADVN+R+K+ +T L +A + E +I + +N+ D G ALH++ L+ + +
Sbjct: 71 HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEM 130
Query: 226 QSLLLSK 232
+LLL+K
Sbjct: 131 VNLLLAK 137
Score = 44.3 bits (103), Expect = 6e-04
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 133 HKSP-INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 191
HK+ +N D + PL +A G +EI L+ GA VN+++ T L A S
Sbjct: 4 HKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEE 63
Query: 192 AVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 234
AV+ LIK AD+N D LH + ++ +++ +S
Sbjct: 64 AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLS 106
Score = 39.7 bits (91), Expect = 0.014
Identities = 20/57 (35%), Positives = 28/57 (49%)
Query: 9 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMI 65
N L+ A ENG A V L+ A T D + T HLA +KGH +C +++
Sbjct: 845 NSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 117 bits (292), Expect = 7e-26
Identities = 165/745 (22%), Positives = 321/745 (43%), Gaps = 121/745 (16%)
Query: 293 GKESVFFAEPPFKAEISSIR-------ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 345
G E+ FAE K +I +R EN DS A + EA + L+ +++
Sbjct: 604 GTETAEFAE--LKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---EMEALRAKLMKVIK 658
Query: 346 AKVASLTL-----------HNKELQD---KLQAKSPKEAEADLSFDSYHSTQTDLGPSLG 391
K SL H E++D KLQ K E ++ + + QT + +
Sbjct: 659 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNF- 716
Query: 392 KPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERK------ 445
TS + + + +L K++++ +++L++ L+ +K+++ E E+
Sbjct: 717 ----TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 772
Query: 446 -QLQVELQSRRAELVCL--NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGL 502
+ ELQ R +L L N +E+S+ L ++L+ + K+ EA +E +SVQ+ M+
Sbjct: 773 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ--- 829
Query: 503 VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTV-I 561
++L EE+ N+L DL+ E + K RE +E+ + K +
Sbjct: 830 ---------ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 880
Query: 562 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD------------TLKS 609
+ + E +M S + MN E +E Q ++ K + T+K+
Sbjct: 881 ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKA 940
Query: 610 QMTQ-EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 668
+ +Q EA+ + E+ K+ + R + +L K++ +E +A E T+E
Sbjct: 941 EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER---------ATSET- 990
Query: 669 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQK-----ENSVSIT 723
K +HE+++Q + ED L + + S +L EL +L++ D K E+++ I
Sbjct: 991 -KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1049
Query: 724 EHLQVITTLRTAAKE--------MEEKISNLKEHLA------SKEVEVAKLEKQLLEEKA 769
E + T A+ E ++ ++ LKE+ +K E+ +E Q +EE
Sbjct: 1050 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109
Query: 770 AMTDAMVPRSSYEKLQ-SSLESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKR 825
+ + ++ + Q S+L+ E LA +L ++ V +K+ E + +++ ++K+
Sbjct: 1110 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1169
Query: 826 -----------EKENIQ-------TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSK 867
EK ++Q LL K+ E+ +L + + E A K
Sbjct: 1170 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1229
Query: 868 LEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 927
LE DK K ++ +LKE LS S +T + + ++ A + Q+ L + + +
Sbjct: 1230 LESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDER--AQESQIDFLNSVIVDL 1287
Query: 928 KKQHQEVISVYRMHLLYAVQGQMDE 952
++++Q++ M A+ G D+
Sbjct: 1288 QRKNQDLKMKVEMMSEAALNGNGDD 1312
Score = 92.8 bits (229), Expect = 1e-18
Identities = 144/694 (20%), Positives = 295/694 (42%), Gaps = 77/694 (11%)
Query: 259 SGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRL 318
S TP K KA S S RS +++ LS SV + + + E R
Sbjct: 285 STTPAKAKANAVRRVMATTS-ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 319 SDSTTGADSLLDISSEADQ--QDLLS---LLQAKVASLTLHNKELQDKL--------QAK 365
+ +G +L + E Q + LL+ L +A+VA T H E++ +L Q
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV 403
Query: 366 SPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQ 425
EA+ D + + L + E + + + +S T D+ +
Sbjct: 404 LELEAKMDQLRTMVEAADREKVELLNQLEE----EKRKVEDLQFRVEEESITKGDLEVAT 459
Query: 426 LQEI--LQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSK 483
+ E + +L+K L E +L+ L+S + + + + S L +KL+ T++
Sbjct: 460 VSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTD 519
Query: 484 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE 543
++ +E+ S+++ + L E+++ + L++ LE + +
Sbjct: 520 HQ---REITSLKEHF-----GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 571
Query: 544 KVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKL 603
V L + +E T I + EE+K S+ + E A L + ++ + +
Sbjct: 572 DVIALWKSKLE----TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE 627
Query: 604 KDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDV 663
+ L++Q E + A++M EA+ ++L ++ KE + LE R +
Sbjct: 628 IENLQNQQDSERAAHAKEM-EALR----------AKLMKVIKEKENSLEAIRSK------ 670
Query: 664 TAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-ELTQLK-----QLVDAQKE 717
+ KAE + L+++ ED L++++ KV E+ Q K +++D
Sbjct: 671 ----LDKAEDQHLVEM--------EDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 718
Query: 718 NSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP 777
+ E L + LR A+ E + ++ L++ L + E ++ LE + E + +
Sbjct: 719 QLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRE 778
Query: 778 RSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS 836
E ++L+ +S + S++KE++ KE + + + + E V+R + L
Sbjct: 779 LQGRELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
Query: 837 KEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 896
KE++ N L ++ +E LA+M+ +K E KD++ ++ K KL+ + + ++
Sbjct: 838 KEEQFNMLSSDLEKLRENLADME------AKFRE-KDEREEQLIKAKEKLENDIAEIMKM 890
Query: 897 SYSTSSS-KRQSQQLEALQQQVKQLQNQLAECKK 929
S SS + + +L ++ V++LQ +L + +
Sbjct: 891 SGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 924
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 117 bits (292), Expect = 7e-26
Identities = 165/745 (22%), Positives = 321/745 (43%), Gaps = 121/745 (16%)
Query: 293 GKESVFFAEPPFKAEISSIR-------ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 345
G E+ FAE K +I +R EN DS A + EA + L+ +++
Sbjct: 639 GTETAEFAE--LKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---EMEALRAKLMKVIK 693
Query: 346 AKVASLTL-----------HNKELQD---KLQAKSPKEAEADLSFDSYHSTQTDLGPSLG 391
K SL H E++D KLQ K E ++ + + QT + +
Sbjct: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNF- 751
Query: 392 KPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERK------ 445
TS + + + +L K++++ +++L++ L+ +K+++ E E+
Sbjct: 752 ----TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 807
Query: 446 -QLQVELQSRRAELVCL--NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGL 502
+ ELQ R +L L N +E+S+ L ++L+ + K+ EA +E +SVQ+ M+
Sbjct: 808 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ--- 864
Query: 503 VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTV-I 561
++L EE+ N+L DL+ E + K RE +E+ + K +
Sbjct: 865 ---------ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 915
Query: 562 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD------------TLKS 609
+ + E +M S + MN E +E Q ++ K + T+K+
Sbjct: 916 ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKA 975
Query: 610 QMTQ-EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 668
+ +Q EA+ + E+ K+ + R + +L K++ +E +A E T+E
Sbjct: 976 EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER---------ATSET- 1025
Query: 669 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQK-----ENSVSIT 723
K +HE+++Q + ED L + + S +L EL +L++ D K E+++ I
Sbjct: 1026 -KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1084
Query: 724 EHLQVITTLRTAAKE--------MEEKISNLKEHLA------SKEVEVAKLEKQLLEEKA 769
E + T A+ E ++ ++ LKE+ +K E+ +E Q +EE
Sbjct: 1085 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1144
Query: 770 AMTDAMVPRSSYEKLQ-SSLESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKR 825
+ + ++ + Q S+L+ E LA +L ++ V +K+ E + +++ ++K+
Sbjct: 1145 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1204
Query: 826 -----------EKENIQ-------TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSK 867
EK ++Q LL K+ E+ +L + + E A K
Sbjct: 1205 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1264
Query: 868 LEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 927
LE DK K ++ +LKE LS S +T + + ++ A + Q+ L + + +
Sbjct: 1265 LESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDER--AQESQIDFLNSVIVDL 1322
Query: 928 KKQHQEVISVYRMHLLYAVQGQMDE 952
++++Q++ M A+ G D+
Sbjct: 1323 QRKNQDLKMKVEMMSEAALNGNGDD 1347
Score = 91.7 bits (226), Expect = 3e-18
Identities = 144/714 (20%), Positives = 299/714 (41%), Gaps = 82/714 (11%)
Query: 259 SGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRL 318
S TP K KA S S RS +++ LS SV + + + E R
Sbjct: 285 STTPAKAKANAVRRVMATTS-ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 319 SDSTTGADSLLDISSEADQ--QDLLS---LLQAKVASLTLHNKELQDKL--------QAK 365
+ +G +L + E Q + LL+ L +A+VA T H E++ +L Q
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV 403
Query: 366 SPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQ 425
EA+ D + + L + E V S+ K + +++
Sbjct: 404 LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEH 463
Query: 426 LQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYE 485
+ +++L++ L + + +LQ EL+ R V + I E DL+ +++E
Sbjct: 464 AR--IKELEQSLLFEKTKADKLQRELEDTRVATVS-EKSRIMELEKDLALRVQE------ 514
Query: 486 EAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKV 545
V ++++++ + + + S E+ +E++ V + D Q + + +
Sbjct: 515 -----VAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR 569
Query: 546 RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFE-----------KYQ 594
E +K ++ + E+ + S S +E+ NKE + + +Q
Sbjct: 570 EETHQKEIK-----ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ 624
Query: 595 EAQEEIMKLKDT-----------LKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQL 643
+A EE+ LK+Q+ + D +++ N+ E E+ L
Sbjct: 625 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 684
Query: 644 YKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN 703
+ +++ K SLE + ++ + KAE + L+++ ED L++++ KV
Sbjct: 685 RAKLMKVIKE--KENSLEAIRSK-LDKAEDQHLVEM--------EDTLNKLQEAEIKVKE 733
Query: 704 -ELTQLK-----QLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEV 757
E+ Q K +++D + E L + LR A+ E + ++ L++ L + E ++
Sbjct: 734 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 793
Query: 758 AKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQI 816
LE + E + + E ++L+ +S + S++KE++ KE + + + +
Sbjct: 794 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEA 852
Query: 817 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 876
E V+R + L KE++ N L ++ +E LA+M+ +K E KD++
Sbjct: 853 SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADME------AKFRE-KDERE 905
Query: 877 NEMSKEVTKLKEALNSLSQLSYSTSSS-KRQSQQLEALQQQVKQLQNQLAECKK 929
++ K KL+ + + ++S SS + + +L ++ V++LQ +L + +
Sbjct: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 959
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/302 (19%), Positives = 128/302 (42%), Gaps = 47/302 (15%)
Query: 683 SRAKAEDALSEMKSQYSKVLNELTQLKQLV--------------DAQKENSVSITEHLQV 728
SR L+E S+Y++ ++ T L++ + D ++ T H+
Sbjct: 328 SRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGE 387
Query: 729 ITTLRTAAK--------EMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSS 780
I A+ E+E K+ L+ + + + E +L QL EEK + D
Sbjct: 388 IEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE 447
Query: 781 YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQE 840
+ LE++ + +++KE + ++ +++ +++RE E+ + S++
Sbjct: 448 ESITKGDLETQTKLEHARIKE-------LEQSLLFEKTKADKLQRELEDTRVATVSEKSR 500
Query: 841 VNELLQKFQQAQEELAEMKRYAESS----------------SKLEEDKDKKINEMSKEVT 884
+ EL + +E+AE++R ES+ S L+E + + +E+T
Sbjct: 501 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 560
Query: 885 KLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLY 944
LKE + + K E L ++ + L+++L K++ +VI++++ L
Sbjct: 561 SLKEHFGAREET--HQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 618
Query: 945 AV 946
A+
Sbjct: 619 AI 620
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 115 bits (288), Expect = 2e-25
Identities = 64/202 (31%), Positives = 107/202 (52%), Gaps = 1/202 (0%)
Query: 15 LLQAVENGDAEKVASLLGK-KGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 73
++ A+ + + + LLG + + G +AA G+++ L+++I G +
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
QD G +A++ AA++ H + ++ L ++KCP + D SG+ ALH AA G Q+LC
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSF 467
Query: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
S N++D + PL A +G+ + L + G +VN +N+ G T L+ A G + V
Sbjct: 468 GSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIV 527
Query: 194 EALIKKGADLNLVDSLGYNALH 215
E L + GADLN D G+ ALH
Sbjct: 528 ECLAEHGADLNACDKDGHIALH 549
Score = 102 bits (254), Expect = 2e-21
Identities = 59/190 (31%), Positives = 93/190 (48%)
Query: 26 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 85
++ LL K+G+ D G A + AA GHV+ L+ + + + +D +G ALH+A
Sbjct: 393 QILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVA 452
Query: 86 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 145
A+ H + + L D +T LH AA G + LCE +N+K+ +G
Sbjct: 453 ARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGE 512
Query: 146 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 205
PLL A G+ +I L +HGAD+N+ +K G AL LA ++ L+ +G ++
Sbjct: 513 TPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDY 572
Query: 206 VDSLGYNALH 215
D G LH
Sbjct: 573 QDRHGNTPLH 582
Score = 96.7 bits (239), Expect = 1e-19
Identities = 58/184 (31%), Positives = 96/184 (52%), Gaps = 3/184 (1%)
Query: 42 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 101
D G+ A H+AA GH + +++ + G + QD + LH AA + ++ + L ++
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAG 501
Query: 102 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 161
C + G+T L A+A+G V+ L EH + +N D DG+I L LAV+ E+
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561
Query: 162 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 221
LL G V+ +++ G T L +AC+ G+ V AL + +L++ + G LH L+
Sbjct: 562 TLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLH---LAA 618
Query: 222 NAGI 225
N GI
Sbjct: 619 NNGI 622
Score = 92.4 bits (228), Expect = 2e-18
Identities = 54/158 (34%), Positives = 78/158 (49%)
Query: 27 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAA 86
VA L + G + + EG+T A+A+G+ + + + HG D+ A D GH ALHLA
Sbjct: 493 VAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAV 552
Query: 87 KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNI 146
+ E I+ LL C + D G T LH A G + V LCE +++ + G
Sbjct: 553 RRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRT 612
Query: 147 PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLA 184
PL LA NG ++ +L GA V + G+TA LA
Sbjct: 613 PLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
Score = 80.1 bits (196), Expect = 9e-15
Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 1/212 (0%)
Query: 18 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 77
A G A+ VA LL G++ D E +T H AA G+ + + G +V ++
Sbjct: 452 AARYGHAD-VAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNRE 510
Query: 78 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 137
G + L A+ +H+ + L + + D G ALH A + ++ ++ L +
Sbjct: 511 GETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFV 570
Query: 138 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 197
+ +D GN PL +A ++G+ I L + +++ NK GRT L LA G + V L
Sbjct: 571 DYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLC 630
Query: 198 KKGADLNLVDSLGYNALHYSKLSENAGIQSLL 229
GA + + + G A ++ ++ + LL
Sbjct: 631 LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 44.7 bits (104), Expect = 4e-04
Identities = 31/110 (28%), Positives = 54/110 (49%), Gaps = 4/110 (3%)
Query: 137 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEAL 196
+N + G PLL+A G+ +I L+ G+ ++ ++K G A+ A G + ++ L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431
Query: 197 IKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS----QDADLKTP 242
+ L++ D G ALH + +A + LL S S QD + +TP
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETP 481
Score = 37.7 bits (86), Expect = 0.053
Identities = 17/49 (34%), Positives = 31/49 (63%)
Query: 169 DVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 217
DVN NK G L++A G+ ++ LIK+G+ +++ D G NA++++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWA 419
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 114 bits (284), Expect = 6e-25
Identities = 74/241 (30%), Positives = 114/241 (47%), Gaps = 4/241 (1%)
Query: 1 MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 60
+ AK ++W L +AV + E V LL K A D +T H+AAA V+C
Sbjct: 67 VNAKDSKWLTP---LHRAVASCSEEAVQVLL-KHSADVNARDKNWQTPLHIAAANKAVKC 122
Query: 61 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA 120
++ +V D G +ALH AA + H E ++ LL + D + A+H+AA
Sbjct: 123 AEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAY 182
Query: 121 QGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTA 180
G ++ V++L H + + KD PL A +G + +LLD G D+N N G T
Sbjct: 183 MGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242
Query: 181 LMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLK 240
L +AC G V LI GA +N + G+ LH++ S + + LL D ++K
Sbjct: 243 LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMK 302
Query: 241 T 241
+
Sbjct: 303 S 303
Score = 114 bits (284), Expect = 6e-25
Identities = 88/292 (30%), Positives = 128/292 (43%), Gaps = 47/292 (16%)
Query: 15 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 74
L+ +V NG + V SLL K GA+ D G+TA H A GH EC+ ++ HG +
Sbjct: 657 LMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR 715
Query: 75 DTTGHSALHLAAKNSHHECIRKLLQSKCPAES----VDSSGKTALHYAAAQGCLQAVQIL 130
D+ G + +HL+A H + LLQS ++ D+ G TALH+A G V++L
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 131 CEHK----------------------------------SPINLKDLDGNIPLLLAVQNGH 156
E + S +N D G PL A H
Sbjct: 776 LEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDH 835
Query: 157 SEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK-GADLNLVDSLGYNALH 215
E LL H A VNS + +G+T LM+A E G +N VE L+ A+L L D+ ALH
Sbjct: 836 VECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALH 895
Query: 216 YSKLSENAGIQSLLLSKISQ-------DADLKTPTKPKQHDQVSKISSERSG 260
+ + L+L KI+ +A L+TP + ++ + E G
Sbjct: 896 LACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLG 947
Score = 109 bits (273), Expect = 1e-23
Identities = 68/233 (29%), Positives = 116/233 (49%), Gaps = 4/233 (1%)
Query: 10 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 69
++ L+QA+ NGD ++V +L+ KK D+E +T H AA G E + ++I G
Sbjct: 7 RDQPSLVQAIFNGDPDEVRALIFKK-EDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
Query: 70 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 129
V A+D+ + LH A + E ++ LL+ + D + +T LH AAA ++ +
Sbjct: 66 RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
Query: 130 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 189
L S +N+ D G L A +GH E+ LL GA++N+ +K R A+ A +G
Sbjct: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
Query: 190 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP 242
V+ L+ GA++ D Y LH + ++G+ S++ + D+ P
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLH---AAASSGMISVVKYLLDLGVDMNEP 235
Score = 106 bits (264), Expect = 1e-22
Identities = 69/210 (32%), Positives = 100/210 (47%), Gaps = 1/210 (0%)
Query: 33 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 92
+ GA D G T H+AA GH + +IT G D + G LHLAA + +
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
Query: 93 CIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAV 152
C RKLL S ++ D G+T LH AAA G L+ + +L + N KD G PL A
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Query: 153 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-AVEALIKKGADLNLVDSLGY 211
N + + L+ GA VN ++ G T L A + +E L++ A+ + D GY
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
Query: 212 NALHYSKLSENAGIQSLLLSKISQDADLKT 241
NA+HYS + L+ S+ D ++T
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMET 536
Score = 104 bits (260), Expect = 4e-22
Identities = 67/197 (34%), Positives = 109/197 (55%), Gaps = 5/197 (2%)
Query: 50 HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDS 109
HLAA GH + L V++ +D+ ++++G + L LAA H EC+ L+ D
Sbjct: 555 HLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDY 614
Query: 110 SGK-TALHYAAAQGCLQAVQILCEHKSP---INLKDLDGNIPLLLAVQNGHSEICHFLLD 165
K T +H AA G + +++L + P ++++D +G PL+L+V NGH++ + LL+
Sbjct: 615 ILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLN 674
Query: 166 HGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGI 225
GA+V++++K GRTAL G V+AL++ GA L DS G +H S + G+
Sbjct: 675 KGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGV 734
Query: 226 -QSLLLSKISQDADLKT 241
+LL S S DA+ T
Sbjct: 735 LGALLQSAASMDANPAT 751
Score = 97.1 bits (240), Expect = 7e-20
Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 1/189 (0%)
Query: 35 GASATKHDSEGKTAFHLAAAKGH-VECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHEC 93
GA + + +G T H AAA H CL +++ +G DV + G + LH+ A +
Sbjct: 262 GAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSR 321
Query: 94 IRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQ 153
+ ++QS + D +G T LH AA G + L + + + G PL LA
Sbjct: 322 SQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAAL 381
Query: 154 NGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNA 213
+G S+ C LL G D+++ + GRT L A G+ + L+ GAD N D G +
Sbjct: 382 SGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441
Query: 214 LHYSKLSEN 222
LHY+ + N
Sbjct: 442 LHYAAANCN 450
Score = 89.7 bits (221), Expect = 1e-17
Identities = 66/263 (25%), Positives = 103/263 (39%), Gaps = 34/263 (12%)
Query: 3 AKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 62
A N ++K D R + +V LL GA T D + T H AA+ G + ++
Sbjct: 164 ANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVK 223
Query: 63 VMITHGVDVTAQDTTGHSALHLAAKNSHHE------------------------------ 92
++ GVD+ + G++ LH+A N
Sbjct: 224 YLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAAST 283
Query: 93 ----CIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPL 148
C+ L+ + GKT LH A G Q + + + I+ +D +GN PL
Sbjct: 284 HGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPL 343
Query: 149 LLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDS 208
+A + GH + + L+ GAD R G L LA G S+ L+ G D++ D
Sbjct: 344 HIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD 403
Query: 209 LGYNALHYSKLSENAGIQSLLLS 231
G LH + N +LLL+
Sbjct: 404 FGRTCLHAAAAGGNLECLNLLLN 426
Score = 89.4 bits (220), Expect = 2e-17
Identities = 59/195 (30%), Positives = 85/195 (43%)
Query: 30 LLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNS 89
LL GA +GKT H+ A G + +I G + +D G++ LH+AA+
Sbjct: 291 LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
Query: 90 HHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLL 149
H I L+ S G LH AA G + L I+ D G L
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLH 410
Query: 150 LAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL 209
A G+ E + LL+ GAD N ++K GR+ L A + + AL+ GA +N +D
Sbjct: 411 AAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470
Query: 210 GYNALHYSKLSENAG 224
G LHY+ S+ G
Sbjct: 471 GCTPLHYAATSDTDG 485
Score = 84.3 bits (207), Expect = 5e-16
Identities = 65/217 (29%), Positives = 112/217 (51%), Gaps = 13/217 (5%)
Query: 22 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 81
G AE + LG +AT DS+G+T H AA HVECL+++++H V + D+TG +
Sbjct: 802 GAAEMLIDTLGASIVNAT--DSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTP 859
Query: 82 LHLAAKNSHHECIRKLLQSKCPAESV-DSSGKTALHYAAAQGCLQAVQILCE---HKSPI 137
L +AA+N + L+ S ++ D+S TALH A ++G + ++ E ++ I
Sbjct: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI 919
Query: 138 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNA----- 192
N + PL +A +NG + + LL GA V + +++G T LAC A
Sbjct: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP-ALACAPNKDVADCLAL 978
Query: 193 VEALIKKGADLNLVDSLGYNALH-YSKLSENAGIQSL 228
+ A + + + + SL +NA++ Y+ S+ ++L
Sbjct: 979 ILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEAL 1015
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 113 bits (282), Expect = 1e-24
Identities = 67/207 (32%), Positives = 98/207 (47%)
Query: 26 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 85
KV LL K GAS G T H+AA GHV + ++ HG + G +ALH+A
Sbjct: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Query: 86 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 145
A++ E +R L+Q E+ +T LH +A G VQ L + + N G
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 146 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 205
PL L+ + GH ++ FLLDHGA ++ K G T L +A + G L++K A +
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Query: 206 VDSLGYNALHYSKLSENAGIQSLLLSK 232
G LH + +N + LLL +
Sbjct: 594 AGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Score = 108 bits (270), Expect = 2e-23
Identities = 66/218 (30%), Positives = 106/218 (48%), Gaps = 1/218 (0%)
Query: 18 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 77
A + G+A V LL + GA +G T H A GH + + +++ + ++
Sbjct: 275 ASKRGNANMVKLLLDR-GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333
Query: 78 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 137
G S LH+A + H C++ LLQ P + V + TALH AA G + ++L + K+
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393
Query: 138 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 197
N K L+G PL +A + ++ LL HGA + + +SG T + +A +G N V L+
Sbjct: 394 NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 453
Query: 198 KKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 235
GA N + G ALH + S A + L+ +Q
Sbjct: 454 HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491
Score = 102 bits (253), Expect = 2e-21
Identities = 68/241 (28%), Positives = 118/241 (48%), Gaps = 9/241 (3%)
Query: 1 MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 60
M ++ KN D + A E + ++ +K + K S+ ++ AA GH+E
Sbjct: 1 MAHAASQLKKNRDLEINAEEEPEKKRKH----RKRSRDRKKKSDANASYLRAARAGHLEK 56
Query: 61 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA 120
I +GVD+ + G +ALHLA+K H E + +LLQ + ++ G TALH A+
Sbjct: 57 ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASL 116
Query: 121 QGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTA 180
G + V++L + + +N + +G PL +A Q H E+ FLLD+GA + + G T
Sbjct: 117 AGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP 176
Query: 181 LMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLK 240
L +A + G V L++ + + ALH + ++ +LLL +AD++
Sbjct: 177 LAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVE 231
Query: 241 T 241
+
Sbjct: 232 S 232
Score = 100 bits (250), Expect = 5e-21
Identities = 86/373 (23%), Positives = 163/373 (43%), Gaps = 34/373 (9%)
Query: 26 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 85
KVA +L K A+ G T H+A K ++ + +++ HG + A +G + +H+A
Sbjct: 381 KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVA 440
Query: 86 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 145
A H + +L+ + + G+TALH AA G + V+ L + + + K D
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ 500
Query: 146 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 205
PL ++ + G ++I LL GA N+ SG T L L+ G + L+ GA L++
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
Query: 206 VDSLGYNALHYSKLSENAGIQSLLLSK-ISQDADLKTPTKP------KQHDQVSKISSER 258
G+ LH + + +LLL K S DA K+ P + +V+ + ++
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 259 SGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRL 318
+P A +P ++ + I +T L + A+ +++
Sbjct: 621 GASP--HAAAKNGYTPLHIAAKKNQMDIATTLLE-----------YGADANAV------- 660
Query: 319 SDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE----AEADL 374
T + + ++++ D++SLL + A++ L NK L + ++ AE +
Sbjct: 661 ---TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717
Query: 375 SFDSYHSTQTDLG 387
+ ++ QT +G
Sbjct: 718 NQGAHVDAQTKMG 730
Score = 100 bits (249), Expect = 7e-21
Identities = 64/235 (27%), Positives = 110/235 (46%), Gaps = 3/235 (1%)
Query: 10 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 69
KN L GD LL + ++ TA H+AA GH + +V++
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 70 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 129
+ A+ G + LH+A K + + + LL+ ++V SG T +H AA G + V
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451
Query: 130 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 189
L H + N ++ G L +A ++G +E+ +L+ GA V ++ K +T L ++ +G
Sbjct: 452 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGK 511
Query: 190 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTK 244
++ V+ L+++GA N + GY LH LS G + + + A L TK
Sbjct: 512 ADIVQQLLQQGASPNAATTSGYTPLH---LSAREGHEDVAAFLLDHGASLSITTK 563
Score = 100 bits (248), Expect = 9e-21
Identities = 71/270 (26%), Positives = 123/270 (45%), Gaps = 7/270 (2%)
Query: 16 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 75
L + D +KVA LL +GAS G T H+AA K ++ ++ +G D A
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 76 TTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKS 135
G +++HLAA+ H + + LL + SG T LH AA + + ++L +
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
Query: 136 PINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEA 195
++ + G PL + G+ +I +FLL H A VN++ K+G T L A + G ++ +
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
Query: 196 LIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQH-----DQ 250
L++ A N + G AL ++ + L KI + + T T ++H +
Sbjct: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTL--KIVTEETMTTTTVTEKHKMNVPET 839
Query: 251 VSKISSERSGTPKKRKAPPPPISPTQLSDV 280
++++ +K AP +SDV
Sbjct: 840 MNEVLDMSDDEVRKANAPEMLSDGEYISDV 869
Score = 97.8 bits (242), Expect = 4e-20
Identities = 63/223 (28%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 22 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 81
G A+ V LL ++GAS + G T HL+A +GH + ++ HG ++ G +
Sbjct: 510 GKADIVQQLL-QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
Query: 82 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 141
LH+AAK E LLQ ++ SG T LH AA + +L + + +
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 142 LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 201
+G PL +A + +I LL++GAD N+ + G ++ LA + G + V L+ + A
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
Query: 202 DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTK 244
++NL + G LH + + + +L ++Q A + TK
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVL---VNQGAHVDAQTK 728
Score = 97.8 bits (242), Expect = 4e-20
Identities = 61/214 (28%), Positives = 102/214 (47%)
Query: 26 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 85
+VA+LL +K AS G T H+AA + + +++ G A G++ LH+A
Sbjct: 579 EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
Query: 86 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 145
AK + + LL+ A +V G ++H AA +G + V +L + +NL + G
Sbjct: 639 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698
Query: 146 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 205
PL LA Q + L++ GA V+++ K G T L + C G+ V L++ A +N
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
Query: 206 VDSLGYNALHYSKLSENAGIQSLLLSKISQDADL 239
GY LH + + I ++LL + +L
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
Score = 94.0 bits (232), Expect = 6e-19
Identities = 56/204 (27%), Positives = 97/204 (47%)
Query: 27 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAA 86
VA+LL + A+ T H+A+ +G+ +++++ G + A+ G + LH A
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGA 309
Query: 87 KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNI 146
++ H + + LL P S +G + LH A L VQ+L +H P++ D
Sbjct: 310 RSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLT 369
Query: 147 PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLV 206
L +A GH ++ LLD A+ N++ +G T L +AC+ +E L+K GA + V
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 207 DSLGYNALHYSKLSENAGIQSLLL 230
G +H + + I S L+
Sbjct: 430 TESGLTPIHVAAFMGHVNIVSQLM 453
Score = 93.2 bits (230), Expect = 1e-18
Identities = 63/206 (30%), Positives = 93/206 (45%)
Query: 25 EKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 84
E VA+ L GAS + +G T H+AA G +E +++ A +G + LH+
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 85 AAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDG 144
AA + + LL + +G T LH AA + + L E+ + N G
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664
Query: 145 NIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLN 204
+ LA Q GH ++ LL A+VN NKSG T L LA + N E L+ +GA ++
Sbjct: 665 IASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD 724
Query: 205 LVDSLGYNALHYSKLSENAGIQSLLL 230
+GY LH N I + LL
Sbjct: 725 AQTKMGYTPLHVGCHYGNIKIVNFLL 750
Score = 92.8 bits (229), Expect = 1e-18
Identities = 60/214 (28%), Positives = 99/214 (46%), Gaps = 1/214 (0%)
Query: 25 EKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 84
E+V +L + A G + H+A H+ C+++++ H V V +ALH+
Sbjct: 314 EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHV 373
Query: 85 AAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDG 144
AA H++ + LL K + +G T LH A + ++ +++L +H + I G
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 145 NIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLN 204
P+ +A GH I L+ HGA N+ N G TAL +A G + V L++ GA +
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493
Query: 205 LVDSLGYNALHYS-KLSENAGIQSLLLSKISQDA 237
LH S +L + +Q LL S +A
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Score = 92.8 bits (229), Expect = 1e-18
Identities = 59/223 (26%), Positives = 102/223 (45%), Gaps = 1/223 (0%)
Query: 10 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 69
+ + L A +G AE V L+ + GA + +T H++A G + ++ ++ G
Sbjct: 465 RGETALHMAARSGQAEVVRYLV-QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA 523
Query: 70 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 129
A T+G++ LHL+A+ H + LL G T LH AA G L+ +
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583
Query: 130 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 189
L + + + G PL +A + ++ LLD GA ++ K+G T L +A +
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643
Query: 190 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 232
+ L++ GAD N V G ++H + + + SLLL +
Sbjct: 644 MDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Score = 77.8 bits (190), Expect = 5e-14
Identities = 55/221 (24%), Positives = 104/221 (47%), Gaps = 11/221 (4%)
Query: 15 LLQAVENGDAEKVASLLGKKGASATKHDSEGKT---AFHLAAAKGHVECLRVMITHGVDV 71
L A++ G + V+ LL ++D++GK A H+AA K + +++ + +
Sbjct: 177 LAVALQQGHDQVVSLLL--------ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228
Query: 72 TAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILC 131
+ +G + LH+AA + LL + + T LH A+ +G V++L
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL 288
Query: 132 EHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 191
+ + I+ K DG PL ++GH ++ LLD A + S+ K+G + L +A + N
Sbjct: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Query: 192 AVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 232
V+ L++ ++ V + ALH + + + +LL K
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Score = 58.2 bits (139), Expect = 4e-08
Identities = 36/128 (28%), Positives = 54/128 (42%)
Query: 3 AKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 62
A N NK+ L D VA +L +GA G T H+ G+++ +
Sbjct: 688 ANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN 747
Query: 63 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 122
++ H V A+ G++ LH AA+ H I LLQ+ + +G TAL A G
Sbjct: 748 FLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 807
Query: 123 CLQAVQIL 130
+ V L
Sbjct: 808 YISVVDTL 815
Score = 49.3 bits (116), Expect = 2e-05
Identities = 119/580 (20%), Positives = 232/580 (40%), Gaps = 90/580 (15%)
Query: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 361
PP S+ + +++DS G D++L+ + Q D Q K + L+ E + +
Sbjct: 2082 PPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHD-----QDK-SPLSDSGFETRSE 2135
Query: 362 LQAKSPKEAEADLSFDSYHS---------TQTDL-------GPSLGKPGETSPPDSKS-S 404
+P+ AE+ +H T+T++ PS G +T P + S
Sbjct: 2136 KTPSAPQSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPK 2195
Query: 405 PSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNT 464
PS L T + ++ E ++ Q + S E + ++ + + E T
Sbjct: 2196 PSPTFMELEPKPTTSSIK-----EKVKAFQMKASSEEDDHNRVLSKGMRVKEETHITTTT 2250
Query: 465 EISENS----SDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVT 520
+ +S S++++ET S ++ MK S + K EL
Sbjct: 2251 RMVYHSPPGGEGASERIEETMSVHD-IMKAFQSGRDPSK----------------ELAGL 2293
Query: 521 EEEINVLKQDL-QNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVI 579
E + + D+ ++A E S ++ EK +++ KL ER +I+ +E+ + + + +
Sbjct: 2294 FEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKL-ER----IIEVHIEKGNQAEPTEVIIR 2348
Query: 580 ENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSE 639
E + ++ ++ + LKD L + E + +E +E E
Sbjct: 2349 ETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLE 2408
Query: 640 LSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYS 699
S++ E ED R +A+ I ++ L L+ S +D LSE++ +
Sbjct: 2409 SSRVNTPVSQE-EDSRPS------SAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESY 2461
Query: 700 KVLNELTQLKQLVDAQKENSVSITEHL-QVITTLRTAAKEMEEKISNL-KEHLASK---- 753
+ ++ ++L + + S+T+H + L+ + K EKI+ K+ + SK
Sbjct: 2462 RFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYKD 2521
Query: 754 --EVEVAKLEKQLLEEKAAM----------TDAMVPRSSYEKLQSSLESEVSVLASKLKE 801
E V K+ K +K + AM R + ++L E + ++
Sbjct: 2522 VSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREK--LIYEDRVDR 2579
Query: 802 SVKEKEKVHSEVVQIRSEVSQVKREK-ENIQTLLKSKEQE 840
+VKE E + +EVSQ R+K E + L+S E++
Sbjct: 2580 TVKEAE-------EKLTEVSQFFRDKTEKLNDELQSPEKK 2612
Score = 42.4 bits (98), Expect = 0.002
Identities = 143/761 (18%), Positives = 275/761 (36%), Gaps = 134/761 (17%)
Query: 236 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAP--------------------PPPISPT 275
D L++P QHDQ S+ + K P PP I+ T
Sbjct: 2106 DTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPPVITET 2165
Query: 276 QLSDV-----------SSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTG 324
+ V P++ P+S K S F E K SSI+E
Sbjct: 2166 RTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQ----- 2220
Query: 325 ADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQT 384
+ SSE D HN+ L ++ K YHS
Sbjct: 2221 ----MKASSEEDD----------------HNRVLSKGMRVKEETHITTTTRM-VYHSPPG 2259
Query: 385 DLGPSLGKPGETSPPDSKSSPSVLIHSLGK---STTDNDVRIQQLQEILQDLQKRLESSE 441
G S + ++ +H + K S D + L E + + S
Sbjct: 2260 GEGAS-----------ERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKSAVSPDVHKSA 2308
Query: 442 AERKQLQVELQSR---RAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQM 498
AE E ++ + E + + E + ++ET+ E KE+ QK +
Sbjct: 2309 AETSAQHAEKDNQMKPKLERIIEVHIEKGNQAEPTEVIIRETKKHPE---KEMYVYQKDL 2365
Query: 499 KLGLVS-----PESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN-----KEKVREL 548
G ++ PE D + E EEE ++ L + LE S N +E R
Sbjct: 2366 SRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLESSRVNTPVSQEEDSRPS 2425
Query: 549 EEKLVEREKGTVIKPPVE---EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD 605
+L+ + +K + EY + + S EK L EK + + ++
Sbjct: 2426 SAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESYRFAEKMLLSEKLDVSHSD---TEE 2482
Query: 606 TLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKE-AQAELEDYRKRKSLEDVT 664
++ +S+ K + ++ K++ LS++YK+ ++ + K + + VT
Sbjct: 2483 SVTDHAGPPSSELQGSDKRSREKIATAPKKEI--LSKIYKDVSENGVGKVSKDEHFDKVT 2540
Query: 665 AEY----IHKAEHEKLMQLTNVSRAKAEDAL---SEMKSQYSKVLNELTQLKQLVDAQKE 717
+ + +H M+ T + + L + + +LT++ Q ++
Sbjct: 2541 VLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQFF---RD 2597
Query: 718 NSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP 777
+ + + LQ + E + + N KE+ +S+ + EK LL E A D V
Sbjct: 2598 KTEKLNDELQ--------SPEKKARPKNGKEY-SSQSPTSSSPEKVLLTELLASNDEWVK 2648
Query: 778 RSSY----EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTL 833
+ + + E S+ +S K + ++ + V+ + +SQ K + Q+
Sbjct: 2649 ARQHGPDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSK-APDGPQSG 2707
Query: 834 LKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSL 893
+ K+ +++ + KF+Q +A+S +ED+ K + V K++E+ +
Sbjct: 2708 FQLKQSKLSSIRLKFEQG--------THAKSKDMSQEDR-KSDGQSRIPVKKIQESKLPV 2758
Query: 894 SQLSYSTSSSKRQSQQLEALQQQVK-QLQNQLAECKKQHQE 933
Y + ++Q + ++ + V Q + + K +H +
Sbjct: 2759 ----YQVFAREKQQKAIDLPDESVSVQKDFMVLKTKDEHAQ 2795
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 113 bits (282), Expect = 1e-24
Identities = 67/214 (31%), Positives = 110/214 (51%), Gaps = 1/214 (0%)
Query: 17 QAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDT 76
+A E+G + + L+G G D EG TA HLAA +GH+ L+ ++ G+D+ Q+
Sbjct: 165 RAAEHGQLDALDFLVGS-GCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNA 223
Query: 77 TGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 136
G +ALH AA SH +C++ LL++ ++ + LHYAA G ++L
Sbjct: 224 EGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGC 283
Query: 137 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEAL 196
N+ D G PL LAV++ + L++ +DVN+ + +T L LA E + + L
Sbjct: 284 ANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADML 343
Query: 197 IKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 230
+ G DLNL D G AL + S + + +++
Sbjct: 344 LIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
Score = 95.1 bits (235), Expect = 3e-19
Identities = 56/188 (29%), Positives = 92/188 (48%), Gaps = 2/188 (1%)
Query: 45 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ--SKC 102
G A L+A GH+ L++++ G + + G + LH AA+ H + +++
Sbjct: 91 GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV 150
Query: 103 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHF 162
+ VD G+TA H AA G L A+ L N+KD +GN L LA GH +
Sbjct: 151 ALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQR 210
Query: 163 LLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSEN 222
L+D G D+ +N G TAL A + V+ L++ G+ +N + + LHY+ LS +
Sbjct: 211 LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 270
Query: 223 AGIQSLLL 230
+ +L+
Sbjct: 271 EDVSRVLI 278
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/224 (28%), Positives = 98/224 (43%), Gaps = 5/224 (2%)
Query: 26 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ--DTTGHSALH 83
++ +L GA +G T H AA KGHV L ++ DV D G +A H
Sbjct: 105 RILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 164
Query: 84 LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLD 143
AA++ + + L+ S C D G TALH AA +G + +Q L + + ++ +
Sbjct: 165 RAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE 224
Query: 144 GNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 203
G L A H + LL G+ VN+ + + L A GS + LI G
Sbjct: 225 GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284
Query: 204 NLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQ 247
N+VD G + LH L+ +L+ I+ D+D+ +Q
Sbjct: 285 NVVDHQGASPLH---LAVRHNFPALVRLLINSDSDVNAVDNRQQ 325
Score = 62.4 bits (150), Expect = 2e-09
Identities = 45/180 (25%), Positives = 74/180 (41%), Gaps = 10/180 (5%)
Query: 7 EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 66
E N L + G LL + G++ + + H AA G + RV+I
Sbjct: 220 EQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
Query: 67 HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 126
G D G S LHLA +++ +R L+ S +VD+ +T LH AA
Sbjct: 280 AGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDI 339
Query: 127 VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLL----------DHGADVNSRNKS 176
+L +NL+D G L +AV++ H + ++ DH +D + ++ S
Sbjct: 340 ADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLS 399
Score = 62.0 bits (149), Expect = 3e-09
Identities = 43/146 (29%), Positives = 75/146 (51%), Gaps = 12/146 (8%)
Query: 82 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 141
LH AA+ ++ +++L+ + + + G+ ALH+AA G QAV++L EH++ ++ +D
Sbjct: 19 LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
Query: 142 LDGNI----------PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 191
G + LLL+ GH I L++ GA ++ +K G T L A + G
Sbjct: 79 AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
Query: 192 AVEALIKKGADLNL--VDSLGYNALH 215
+ +++ D+ L VD LG A H
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFH 164
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 112 bits (280), Expect = 2e-24
Identities = 147/675 (21%), Positives = 297/675 (44%), Gaps = 133/675 (19%)
Query: 353 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 412
L K+ Q K Q K+ + D+ +H D + K GE + K + + +L
Sbjct: 777 LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESK-GEMKKENMKKDEA--LKAL 833
Query: 413 GKSTTDNDVRIQQLQEILQ----DLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISE 468
++ ++++QL L+ +L L E +++ + +L+ + E+ CL +
Sbjct: 834 QNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
Query: 469 NSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLK 528
N S L+ET S+ ++ L Q+QM + E++ N E++++ L+
Sbjct: 894 NHS-----LQET-SEQNVILQHTLQQQQQM----LQQETIRNGELEDTQTKLEKQVSKLE 943
Query: 529 QDLQNALEESERNKEKVRELEEKL--------VEREK-----GTV--IKPPVEEYEEM-- 571
Q+LQ ++ E + EK+R++EEK ++R+K GT +K +++Y+E
Sbjct: 944 QELQ---KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 1000
Query: 572 ---------------KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 616
K+ + S ++ + + EK A +E+ KL+ + ++++T EA
Sbjct: 1001 KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT-EAL 1059
Query: 617 DEAEDMKEAMNRMIDELN---KQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 673
+ E ++ + EL +Q+ EL + ++AQ LE+ K +++D+TAE
Sbjct: 1060 QKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE--KYTTIKDLTAE------- 1110
Query: 674 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ----KENSVSITEHLQVI 729
L E K + EL ++ Q + + K+ + +T HL +
Sbjct: 1111 -----------------LRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVT-HLDM- 1151
Query: 730 TTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLE 789
T+R EME+KI L+ L E+E+ + KQ+ S +KLQ++
Sbjct: 1152 -TIREHRGEMEQKIIKLEGTLEKSELELKECNKQI-------------ESLNDKLQNA-- 1195
Query: 790 SEVSVLASKLKESVKEKEKV----HSEVVQIRSEVSQVKREKENIQTLLKSKEQEV-NEL 844
KE ++EKE + E+ Q++ E+ + ++ + +++++K +EQ + +
Sbjct: 1196 ----------KEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQY 1245
Query: 845 LQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS------- 897
+ QE ++ S ++L E + +++ + +E+ +L L + QLS
Sbjct: 1246 KEAIDLGQELRLTREQVQNSHTELAEARHQQV-QAQREIERLSSELEDMKQLSKEKDAHG 1304
Query: 898 ----YSTSSSKRQSQQLEA-LQQQVKQLQNQLAECKK-QHQEVISVYRMHLLYAVQGQMD 951
+SK + LEA +Q ++K+L ++ K+ H E+IS H + +
Sbjct: 1305 NHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQ 1364
Query: 952 EDVQKVLKQILTMCK 966
+ + L + L K
Sbjct: 1365 KSSVQQLNEQLEKAK 1379
Score = 77.4 bits (189), Expect = 6e-14
Identities = 129/585 (22%), Positives = 263/585 (44%), Gaps = 72/585 (12%)
Query: 408 LIHSLGKSTTDNDVRIQQLQEILQDLQK-RLESSEAERKQLQVELQSRRAELVCLNNTEI 466
L L K N + Q ++ + E +++ K +E ++A V + +I
Sbjct: 234 LREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQI 293
Query: 467 SENSSDLSQK---LKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEE 523
+++S + L+E ++K E++ K V+ ++ L+ ++EE
Sbjct: 294 INLEAEVSAQDKVLREAENKLEQSQKMVIEKEQS-------------------LQESKEE 334
Query: 524 INVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI----KPPVEEYEEMKSSYCSVI 579
LK DL LE++++ K R+ E L E+ + K V E E + ++
Sbjct: 335 CIKLKVDL---LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEIL 391
Query: 580 E----NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 635
E N KE L E+ + E+ LK+ L+ Q+ +E ++ E ++ M E+
Sbjct: 392 ERNLTNCEKENKRLQERCGLYKSELEILKEKLR-QLKEENNNGKEKLR-IMAVKNSEVMA 449
Query: 636 QVSELSQLYKEAQAELED----YRKRKSLEDVTAEYIHK--AEHEKLMQLTNVSRAKAED 689
Q++E Q + ++ELE+ R + SL + E + A++E+L ++ + + E
Sbjct: 450 QLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERL----DLCQQEIES 505
Query: 690 ALSEMKSQYSKVLNELTQLKQLVDAQKENS-VSITEHLQVITTLRTAAKEMEEKISNLKE 748
+ E++S K++++L ++L + S ++ + + IS L+
Sbjct: 506 SRVELRS-LEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRI 564
Query: 749 HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESE-VSVLASKLKESVKEKE 807
LA KE E+ KL L + + + S SSLE+E V + ++ ESVK++
Sbjct: 565 KLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQN 624
Query: 808 KVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL-------LQKFQQAQEELAEMKR 860
+ H+ Q E ++ E ++T L E E ++L +FQ QEEL E
Sbjct: 625 Q-HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK-- 681
Query: 861 YAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQL 920
A +SSKLE + KK +++ +L+E + ++YS+ ++K + E +++ K +
Sbjct: 682 -ASNSSKLESEMTKKCSQLLTLEKQLEEKI-----VAYSSIAAKNAELEQELMEKNEK-I 734
Query: 921 QNQLAECKKQHQEVISVY----RMHLLYAVQGQMDEDVQKVLKQI 961
++ +H+++ + ++HL +M++ ++++ Q+
Sbjct: 735 RSLETNINTEHEKICLAFEKAKKIHL--EQHKEMEKQIERLEAQL 777
Score = 54.3 bits (129), Expect = 5e-07
Identities = 109/500 (21%), Positives = 198/500 (39%), Gaps = 100/500 (20%)
Query: 515 HELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLV----EREKGTVIKPPVEEYEE 570
HEL++TE + L ++L + + EKL+ G + P YE
Sbjct: 145 HELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSP---YEN 201
Query: 571 MKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL----------------------- 607
+ S + K + +F +EI L++ L
Sbjct: 202 VCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFES 261
Query: 608 ----------KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED---- 653
K M + A +A + + I L +VS ++ +EA+ +LE
Sbjct: 262 IHFELTQSRAKVSMLESAQQQAASV-PILEEQIINLEAEVSAQDKVLREAENKLEQSQKM 320
Query: 654 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAE--------DALSEMKSQYSKVLNE 704
K +SL++ E I K + + L Q RA+ + + LS+ QY K + E
Sbjct: 321 VIEKEQSLQESKEECI-KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAE 379
Query: 705 LTQLKQ---------LVDAQKENSVSITE----HLQVITTLRTAAKEMEEKISNLKEHLA 751
+ Q L + +KEN + E + + L+ ++++E+ +N KE L
Sbjct: 380 KLEKVQAEEEILERNLTNCEKENK-RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLR 438
Query: 752 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 811
V+ +++ QL E R S KL+S LE++ +L K + E ++
Sbjct: 439 IMAVKNSEVMAQLTES----------RQSILKLESELENKDEILRDKF-SLMNENRELKV 487
Query: 812 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 871
V + ++E E+ + L+S E+ +++L K ++ + + +Y SS +ED
Sbjct: 488 RVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK-RELFGFKSYLSKYQMSSFSNKED 546
Query: 872 KDKKINEMSK---------------EVTKLKEAL--NSLSQLSYSTSSSKRQSQQLEALQ 914
+ E +K E+ KL L N LSQ S T + ++S +L +L+
Sbjct: 547 RCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQ-SLITCNDSQESSKLSSLE 605
Query: 915 -QQVKQLQNQLAECKKQHQE 933
+ VK +Q+AE K +
Sbjct: 606 TEPVKLGGHQVAESVKDQNQ 625
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.122 0.313
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,392,500
Number of Sequences: 37866
Number of extensions: 1477112
Number of successful extensions: 29507
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 862
Number of HSP's successfully gapped in prelim test: 1624
Number of HSP's that attempted gapping in prelim test: 9917
Number of HSP's gapped (non-prelim): 9982
length of query: 972
length of database: 18,247,518
effective HSP length: 112
effective length of query: 860
effective length of database: 14,006,526
effective search space: 12045612360
effective search space used: 12045612360
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.