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Search of human proteins with 224809470
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
(980 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 1874 0.0
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 1874 0.0
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 1874 0.0
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 1853 0.0
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 1852 0.0
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 1800 0.0
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 355 9e-98
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 351 2e-96
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 286 7e-77
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 272 1e-72
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 139 1e-32
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 139 1e-32
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 139 2e-32
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 132 1e-30
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 132 1e-30
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 132 1e-30
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa... 127 7e-29
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 126 1e-28
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 124 4e-28
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa... 123 7e-28
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 117 4e-26
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 117 5e-26
gi|38044112 restin isoform b [Homo sapiens] 117 7e-26
gi|4506751 restin isoform a [Homo sapiens] 117 7e-26
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 116 9e-26
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 115 2e-25
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 114 6e-25
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 113 1e-24
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 113 1e-24
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 112 2e-24
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1874 bits (4854), Expect = 0.0
Identities = 980/980 (100%), Positives = 980/980 (100%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA
Sbjct: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
Query: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK
Sbjct: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS
Sbjct: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Query: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300
ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS
Sbjct: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300
Query: 301 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 360
GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT
Sbjct: 301 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 360
Query: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL
Sbjct: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
Query: 421 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 480
GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD
Sbjct: 421 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 480
Query: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 540
LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ
Sbjct: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 540
Query: 541 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK
Sbjct: 541 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
Query: 601 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 660
YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE
Sbjct: 601 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 660
Query: 661 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 720
DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV
Sbjct: 661 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 720
Query: 721 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT
Sbjct: 721 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
Query: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 840
DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT
Sbjct: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 840
Query: 841 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 900
LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS
Sbjct: 841 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 900
Query: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 960
LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE
Sbjct: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 960
Query: 961 DVQKVLKQILTMCKNQSQKK 980
DVQKVLKQILTMCKNQSQKK
Sbjct: 961 DVQKVLKQILTMCKNQSQKK 980
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1874 bits (4854), Expect = 0.0
Identities = 980/980 (100%), Positives = 980/980 (100%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA
Sbjct: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
Query: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK
Sbjct: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS
Sbjct: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Query: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300
ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS
Sbjct: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300
Query: 301 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 360
GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT
Sbjct: 301 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 360
Query: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL
Sbjct: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
Query: 421 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 480
GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD
Sbjct: 421 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 480
Query: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 540
LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ
Sbjct: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 540
Query: 541 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK
Sbjct: 541 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
Query: 601 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 660
YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE
Sbjct: 601 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 660
Query: 661 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 720
DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV
Sbjct: 661 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 720
Query: 721 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT
Sbjct: 721 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
Query: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 840
DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT
Sbjct: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 840
Query: 841 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 900
LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS
Sbjct: 841 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 900
Query: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 960
LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE
Sbjct: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 960
Query: 961 DVQKVLKQILTMCKNQSQKK 980
DVQKVLKQILTMCKNQSQKK
Sbjct: 961 DVQKVLKQILTMCKNQSQKK 980
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1874 bits (4854), Expect = 0.0
Identities = 980/980 (100%), Positives = 980/980 (100%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA
Sbjct: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
Query: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK
Sbjct: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS
Sbjct: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Query: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300
ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS
Sbjct: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300
Query: 301 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 360
GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT
Sbjct: 301 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 360
Query: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL
Sbjct: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
Query: 421 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 480
GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD
Sbjct: 421 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 480
Query: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 540
LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ
Sbjct: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 540
Query: 541 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK
Sbjct: 541 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
Query: 601 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 660
YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE
Sbjct: 601 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 660
Query: 661 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 720
DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV
Sbjct: 661 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 720
Query: 721 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT
Sbjct: 721 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
Query: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 840
DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT
Sbjct: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 840
Query: 841 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 900
LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS
Sbjct: 841 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 900
Query: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 960
LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE
Sbjct: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 960
Query: 961 DVQKVLKQILTMCKNQSQKK 980
DVQKVLKQILTMCKNQSQKK
Sbjct: 961 DVQKVLKQILTMCKNQSQKK 980
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 1853 bits (4800), Expect = 0.0
Identities = 972/977 (99%), Positives = 973/977 (99%), Gaps = 2/977 (0%)
Query: 4 LKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 63
L AK +K TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK
Sbjct: 9 LSAKEKK--TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 66
Query: 64 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 123
GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL
Sbjct: 67 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 126
Query: 124 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 183
HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK
Sbjct: 127 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 186
Query: 184 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 243
SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ
Sbjct: 187 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 246
Query: 244 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE 303
DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE
Sbjct: 247 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE 306
Query: 304 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 363
SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN
Sbjct: 307 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 366
Query: 364 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 423
KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS
Sbjct: 367 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 426
Query: 424 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 483
TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ
Sbjct: 427 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 486
Query: 484 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 543
KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL
Sbjct: 487 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 546
Query: 544 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 603
EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE
Sbjct: 547 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 606
Query: 604 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 663
AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR
Sbjct: 607 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 666
Query: 664 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 723
KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ
Sbjct: 667 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 726
Query: 724 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 783
KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM
Sbjct: 727 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 786
Query: 784 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 843
VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK
Sbjct: 787 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 846
Query: 844 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 903
SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ
Sbjct: 847 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 906
Query: 904 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 963
LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ
Sbjct: 907 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 966
Query: 964 KVLKQILTMCKNQSQKK 980
KVLKQILTMCKNQSQKK
Sbjct: 967 KVLKQILTMCKNQSQKK 983
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 1852 bits (4797), Expect = 0.0
Identities = 968/971 (99%), Positives = 970/971 (99%)
Query: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
++ TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL
Sbjct: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
Query: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ
Sbjct: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
Query: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL
Sbjct: 122 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 181
Query: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT
Sbjct: 182 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 241
Query: 250 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 309
PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE
Sbjct: 242 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 301
Query: 310 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 369
PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK
Sbjct: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 361
Query: 370 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 429
LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV
Sbjct: 362 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 421
Query: 430 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 489
RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ
Sbjct: 422 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 481
Query: 490 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 549
SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN
Sbjct: 482 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 541
Query: 550 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 609
KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM
Sbjct: 542 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 601
Query: 610 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 669
KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE
Sbjct: 602 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 661
Query: 670 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 729
DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS
Sbjct: 662 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 721
Query: 730 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 789
ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY
Sbjct: 722 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 781
Query: 790 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 849
EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV
Sbjct: 782 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 841
Query: 850 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 909
NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS
Sbjct: 842 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 901
Query: 910 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 969
SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI
Sbjct: 902 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 961
Query: 970 LTMCKNQSQKK 980
LTMCKNQSQKK
Sbjct: 962 LTMCKNQSQKK 972
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 1800 bits (4661), Expect = 0.0
Identities = 951/980 (97%), Positives = 951/980 (97%), Gaps = 29/980 (2%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA
Sbjct: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
Query: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK
Sbjct: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS
Sbjct: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Query: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300
ISQDADLKTPTKPKQ LSDVSSPRSITSTPLS
Sbjct: 241 ISQDADLKTPTKPKQ-----------------------------LSDVSSPRSITSTPLS 271
Query: 301 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 360
GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT
Sbjct: 272 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 331
Query: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL
Sbjct: 332 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 391
Query: 421 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 480
GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD
Sbjct: 392 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 451
Query: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 540
LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ
Sbjct: 452 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 511
Query: 541 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK
Sbjct: 512 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 571
Query: 601 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 660
YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE
Sbjct: 572 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 631
Query: 661 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 720
DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV
Sbjct: 632 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 691
Query: 721 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT
Sbjct: 692 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 751
Query: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 840
DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT
Sbjct: 752 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 811
Query: 841 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 900
LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS
Sbjct: 812 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 871
Query: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 960
LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE
Sbjct: 872 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 931
Query: 961 DVQKVLKQILTMCKNQSQKK 980
DVQKVLKQILTMCKNQSQKK
Sbjct: 932 DVQKVLKQILTMCKNQSQKK 951
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 355 bits (912), Expect = 9e-98
Identities = 303/1127 (26%), Positives = 526/1127 (46%), Gaps = 187/1127 (16%)
Query: 1 MKSLKAKFRKSDTN---------------EWNKNDDRLLQAVENGDAEKVASLLGKKGAS 45
MKSLK++ R+ D +WNK DDRL++A E GD EKV S+L KKG +
Sbjct: 1 MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN 60
Query: 46 ATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKL 105
K D EG++ FH+ +KG++ECL ++ HGVD+T DT G +ALHLAAK H C++KL
Sbjct: 61 PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL 120
Query: 106 LQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHS 165
LQ CP E D G+TALH AA C ++Q+LC+H + +N KD+DG PL+LA Q
Sbjct: 121 LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP 180
Query: 166 EICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 225
IC L+D GADVNSR+K RTALML CE G +AVE LIK GAD++L+D+LG+++ +Y+
Sbjct: 181 TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 240
Query: 226 KLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQL 285
++ +N I +LL K +SE + ++ P + L
Sbjct: 241 RIGDNLDILTLL-----------------------KTASENTNKGRELWKKGPSLQQRNL 277
Query: 286 SDVSSPRSITSTPLSGK--ESVFFAEPPFKAEISSIRENKDRLSDSTTG------ADSLL 337
+ + ++ S + + + K + I++ + L D G + ++
Sbjct: 278 THMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMV 337
Query: 338 DISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSP-KEAEAD-LSFDSYHSTQTDLG 395
E++++ L SLL AK H + L+ K+ K E+D L S+ S + +
Sbjct: 338 ADDLESEREKLKSLLAAKEKQ---HEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE-- 392
Query: 396 PSLGKPGETSPPDSK-SSPSVLIH------------SLGKSTTDNDVRIQQLQEILQDLQ 442
L K G+ DS+ +SP + H SL T+ ++ I L++ L+ ++
Sbjct: 393 DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEI--LKKELEAMR 450
Query: 443 KRLESSEAERKQLQVELQSRRAE--LVCLNNTEISENSSD----LSQKLKETQSKYEEAM 496
ES++ +R +LQ EL + AE + L + E+S + L LK+ Q + E+
Sbjct: 451 TFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESE 510
Query: 497 KEVLSVQKQ---MKLGLVSPESMDNYSHFHELRVTEEEINV------------------- 534
+V +Q +K L S + N+ EL+ +++ V
Sbjct: 511 GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQN 570
Query: 535 --------------------LKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVE 574
L+++L E E+ KV E+E + E + P E
Sbjct: 571 EMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAE 630
Query: 575 EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEAS-DEAEDM 630
++E MKSS + + K+ + +++++ EI +LK + +K+++ Q +E E +
Sbjct: 631 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 690
Query: 631 KEAMNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLED----VTAE----YI----- 676
K + + EL K+++EL+ + Q E+E Y K L++ +T E Y+
Sbjct: 691 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 750
Query: 677 --HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHL 734
K H+ ++ N +E K + K+L E L + V + V +H
Sbjct: 751 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHE 810
Query: 735 QVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQS 794
+ I L++ E+++++S LK+ + ++ L + K M++ VP ++E+++
Sbjct: 811 KEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKM 870
Query: 795 SLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS---------- 844
+L ++ +L + K+ E ++ E V+I+ + +KR EN Q +K+
Sbjct: 871 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEA 930
Query: 845 ----------KEQEVN-ELLQKFQQAQEEL----AEMKRYAESSSKLE------------ 877
K Q+ N E+L +++ QEE+ AE+K + ++
Sbjct: 931 KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 990
Query: 878 -EDKDKKINEMSKEVTKLKEALNSLSQ-LSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 935
E+ ++K KE LK+ L+ +Q S S K+ Q+ + L++++ LQ L +
Sbjct: 991 FEECERKFKATEKE---LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD- 1046
Query: 936 KKQHQEVISVYRMHLLYAVQGQMDEDVQKVLK---QILTMCKNQSQK 979
+ + + + H + + +++ K LK Q T KN +K
Sbjct: 1047 -----KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
Score = 232 bits (591), Expect = 1e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 223 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 282
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 657 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 707
Query: 283 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 336
L + + + I L K E K ++ ++D D L
Sbjct: 708 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 767
Query: 337 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 392
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 768 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 821
Query: 393 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 822 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 869
Query: 453 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 512
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 870 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 924
Query: 513 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 568
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 925 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 977
Query: 569 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 619
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 978 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1037
Query: 620 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 667
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 1038 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
Query: 668 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 721
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1157
Query: 722 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 779
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1217
Query: 780 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 837
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 1218 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1277
Query: 838 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 897
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 1278 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1334
Query: 898 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 956
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 1335 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1394
Query: 957 QMDEDVQKVLKQILTM 972
MDEDVQ+ L QI+ M
Sbjct: 1395 HMDEDVQEALLQIIQM 1410
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 351 bits (901), Expect = 2e-96
Identities = 296/1098 (26%), Positives = 516/1098 (46%), Gaps = 172/1098 (15%)
Query: 15 EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 74
+WNK DDRL++A E GD EKV S+L KKG + K D EG++ FH+ +KG++ECL ++
Sbjct: 17 DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI 76
Query: 75 HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 134
HGVD+T DT G +ALHLAAK H C++KLLQ CP E D G+TALH AA C +
Sbjct: 77 HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSS 136
Query: 135 VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194
+Q+LC+H + +N KD+DG PL+LA Q IC L+D GADVNSR+K RTALML CE
Sbjct: 137 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCE 196
Query: 195 IGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPK 254
G +AVE LIK GAD++L+D+LG+++ +Y+++ +N I +LL
Sbjct: 197 YGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL----------------- 239
Query: 255 QHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK--ESVFFAEPPF 312
K +SE + ++ P + L+ + ++ S + + +
Sbjct: 240 ------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDL 293
Query: 313 KAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLTLHNKEL 366
K + I++ + L D G + ++ E++++ L SLL AK H + L
Sbjct: 294 KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ---HEESL 350
Query: 367 QDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH----- 418
+ K+ K E+D L S+ S + + L K G+ DS+ +SP + H
Sbjct: 351 RTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPAHMQSRS 408
Query: 419 -------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE--LVCL 469
SL T+ ++ I L++ L+ ++ ES++ +R +LQ EL + AE + L
Sbjct: 409 MLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAL 466
Query: 470 NNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESMDNYSHF 522
+ E+S + L LK+ Q + E+ +V +Q +K L S + N+
Sbjct: 467 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 526
Query: 523 HELRVTEEEINV---------------------------------------LKQDLQNAL 543
EL+ +++ V L+++L
Sbjct: 527 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 586
Query: 544 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 603
E E+ KV E+E + E + P E++E MKSS + + K+ + ++++
Sbjct: 587 MEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEK 646
Query: 604 AQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL 659
+ EI +LK + +K+++ Q +E E +K + + EL K+++EL+ + Q E+
Sbjct: 647 SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI 706
Query: 660 ED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAEDALSEMK 703
E Y K L++ +T E Y+ K H+ ++ N +E K
Sbjct: 707 EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKK 766
Query: 704 SQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEV 763
+ K+L E L + V + V +H + I L++ E+++++S LK+ +
Sbjct: 767 LEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 826
Query: 764 EVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQ 823
++ L + K M++ VP ++E+++ +L ++ +L + K+ E ++ E V+
Sbjct: 827 KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVK 886
Query: 824 IRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKFQQAQEE 862
I+ + +KR EN Q +K+ K Q+ N E+L +++ QEE
Sbjct: 887 IKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEE 946
Query: 863 L----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALNSLSQ-L 904
+ AE+K + ++ E+ ++K KE LK+ L+ +Q
Sbjct: 947 IVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLSEQTQKY 1003
Query: 905 SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQK 964
S S K+ Q+ + L++++ LQ L + + + + + H + + +++ K
Sbjct: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRKTDELNK 1057
Query: 965 VLK---QILTMCKNQSQK 979
LK Q T KN +K
Sbjct: 1058 QLKDLSQKYTEVKNVKEK 1075
Score = 232 bits (591), Expect = 1e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 223 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 282
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 644 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 694
Query: 283 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 336
L + + + I L K E K ++ ++D D L
Sbjct: 695 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
Query: 337 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 392
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 755 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 808
Query: 393 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 809 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 856
Query: 453 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 512
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 857 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 911
Query: 513 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 568
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 912 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 964
Query: 569 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 619
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 965 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1024
Query: 620 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 667
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
Query: 668 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 721
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1144
Query: 722 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 779
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1204
Query: 780 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 837
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 1205 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1264
Query: 838 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 897
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 1265 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1321
Query: 898 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 956
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 1322 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1381
Query: 957 QMDEDVQKVLKQILTM 972
MDEDVQ+ L QI+ M
Sbjct: 1382 HMDEDVQEALLQIIQM 1397
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 286 bits (732), Expect = 7e-77
Identities = 271/1035 (26%), Positives = 458/1035 (44%), Gaps = 102/1035 (9%)
Query: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
+ + +W K+D+RLLQAVEN DA +VA+L+ +KG TK D EGK+AFHLAA +G CL
Sbjct: 39 RRQSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCL 98
Query: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
VMI HG +V + D G++ALHLAAK H +C+++LLQ+ C + VDSSG TALH+AAA
Sbjct: 99 EVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAG 158
Query: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
GCL ++LC K+ +N +D G PL++A Q H+++C LL GA N ++ GRTAL
Sbjct: 159 GCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTAL 218
Query: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
MLACE S VE L++ GA + D+LG +A HY L+ + L+L + + A +
Sbjct: 219 MLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGD----KLILHLLQEAAQRPS 274
Query: 250 PTKPKQHDQVSKISSERS-------GTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 302
P D + SS+ S G PKKRKAPPPP S D + I
Sbjct: 275 PPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERG 334
Query: 303 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ-QDLLSLLQAKVASLTL 361
+ +I + ++K+R + A SL + + + Q LL Q + SL
Sbjct: 335 RLL--------QKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGR 386
Query: 362 HNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLG 421
+ LQ +L S E E + + + Q + G PG + SPS H L
Sbjct: 387 EVESLQSRL---SLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEH-LA 442
Query: 422 KSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN-----TEISE 476
V +Q QE+++ +Q LE+ E + Q++VE + L ++ ++
Sbjct: 443 SLQEQVAVLTRQNQELMEKVQ-ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRR 501
Query: 477 NSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLK 536
++ Q L++ +++ E +E + + G + ++ + + E ++N
Sbjct: 502 QHAEALQALRQQETR-EVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNG-A 559
Query: 537 QDLQNALEESERNKEKVRELEEKLVER-------EKGTVIKPPVEEYEEMKSSYCSVIEN 589
+ + E + + E E E K T KP E EM+++
Sbjct: 560 ETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETT------- 612
Query: 590 MNKEKAFLFEKYQEAQEEIMKLK--DTLKSQMTQEASDEAE------------------- 628
+E+A + K AQ + + + + T+ ++EAE
Sbjct: 613 --EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTT 670
Query: 629 DMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHE---KLM 685
+M+ +R + VS +A + L AE K + E ++
Sbjct: 671 NMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIR 730
Query: 686 QLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITT 739
L R + +A +E+++ K + +L + +E S + Q+
Sbjct: 731 GLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAA 790
Query: 740 LRTAAKEMEEKISNLKE-HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLES 798
L A +++ ++ S L+E AS ++ A+ + L EE+A A + + +L+ S E
Sbjct: 791 LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSREL 850
Query: 799 EVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQ 858
EV L+E + + +E+ + + E L + +E + L + ++
Sbjct: 851 EV------LREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELRE 904
Query: 859 AQEELAEMKRYAESSSKLEEDK----------DKKINEMSKEVTKLKEALNSLSQLSYST 908
A E L + A +L+E+ ++++ KE +L+ L S +
Sbjct: 905 ASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVAL 964
Query: 909 SSSKRQSQQLEALQQQVKQLQNQLAECKKQHQ----EVISVYRMHLLYAVQGQMDEDVQK 964
S +R + LQ V QL+ QL E ++H+ EV V R L + E
Sbjct: 965 SEHER---IVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLA 1021
Query: 965 VLKQILTMCKNQSQK 979
+Q L + ++++
Sbjct: 1022 TAEQQLRGLRTEAER 1036
Score = 157 bits (397), Expect = 5e-38
Identities = 131/454 (28%), Positives = 222/454 (48%), Gaps = 39/454 (8%)
Query: 531 EINVLKQDLQNALEESERNKEKVRELEEKL-----VEREKGTVIKPPVEEYEEMKSSYCS 585
E+ + L+ AL + ER E ELE L E E G ++ V E E +S
Sbjct: 724 ELETRIRGLEEALRQRER--EAAAELEAALGKCEAAEAEAGR-LRERVREAEGSGASGGG 780
Query: 586 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQ 644
+ A ++A+E++ L+ A DEA + L +
Sbjct: 781 GGDTTQLRAAL-----EQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
Query: 645 VSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKS 704
+++ + E ELE R++ + T E A E +R AE ++E+ +
Sbjct: 836 LAQREEARLEQSRELEVLREQLATARATGEQQRTAAAE-----LGRARDAAEARVAELPA 890
Query: 705 QYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE 764
+ L +L++ +A +++ V +EH + L+ A E+ + ++L++ + + E
Sbjct: 891 ACEEARQGLAELREASEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGKE 946
Query: 765 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 824
A+L +L E+ V S +E++ +L++ V+ L +L+E + EK +EV Q+
Sbjct: 947 AARLRAELERERVCS----VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
Query: 825 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 884
+ E +K E+ + L + EQ++ L + ++A++ R E+ K +E KDKKI
Sbjct: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA---QSRAQEALDKAKE-KDKKI 1058
Query: 885 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 944
E+SKEV LKEAL + + ++EAL+ QVK LQ QL E + H V++
Sbjct: 1059 TELSKEVFNLKEALKE--------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
Query: 945 VYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 978
+YR HLLYA+QGQMDEDVQ++L QIL M + Q+Q
Sbjct: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
Score = 30.8 bits (68), Expect = 6.5
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 12/133 (9%)
Query: 431 IQQLQEILQDLQKRLESSEAERKQLQVE---LQSRR--AELVCLNNTEISENSSDLSQKL 485
+ QL+ L++L +R E + AE Q+Q E ++S R AE + +++
Sbjct: 978 VAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA 1037
Query: 486 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE--LRVTEEEINVLK---QDLQ 540
++ QS+ +EA+ + + +K K+ +S E + E + E+ L+ +DLQ
Sbjct: 1038 RQAQSRAQEALDK--AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ 1095
Query: 541 NALEESERNKEKV 553
L+E+ R+ V
Sbjct: 1096 QQLQEAARDHSSV 1108
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 272 bits (696), Expect = 1e-72
Identities = 254/1027 (24%), Positives = 462/1027 (44%), Gaps = 115/1027 (11%)
Query: 16 WNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH 75
WN++D +LL+AV GD +VA+L +K A TK DS G++ FHLAA+KG ECL +++ +
Sbjct: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
Query: 76 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
G D+ +++ G +ALHLA + +C++ LLQ ++VD+ ++ LH+AA+ GC +V
Sbjct: 77 GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
Query: 136 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 195
+LC+H++ +++ D DG PL++A GH+ IC LL GA VN +K+ ++AL+LACE
Sbjct: 137 LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196
Query: 196 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQ 255
GS+ E L+ GAD VDS G++ALHY+ +++ + L +S+ + + Q
Sbjct: 197 GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRR--RGGQRLVQ 254
Query: 256 HDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAE 315
H ++ +S P + +A PP S + +E + E +
Sbjct: 255 HPDLASQAS-----PSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKV 309
Query: 316 ISSIRENKDRLSDSTTGADSLLDISSEADQ--QDLLSLLQAKVASLTLHNKELQ---DKL 370
+ +E + + T A + LD+ ++ + Q+L LL + + L+ D +
Sbjct: 310 VRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGM 369
Query: 371 QAKSPKE--AEADLSFDSYHSTQTDLGPSL--------------------GKPGETSPPD 408
+ PK+ AE+ + P L +P E PP
Sbjct: 370 EQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQ 429
Query: 409 SKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ-LQVELQSRRAELV 467
S +S ++ + T + Q D +L + + E Q L VE AE V
Sbjct: 430 SPASETI------RKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVAEPV 483
Query: 468 --CLNNTEISENSSDLSQKLKETQS---------------------------KYEEAMKE 498
N + + +L+ +E + K E ++
Sbjct: 484 GPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLER 543
Query: 499 VLSVQKQMKLGL-VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVR--E 555
VL+ + K GL V PE S L+ I KQD EE E+ R
Sbjct: 544 VLARLEWAKAGLQVKPEVPSQESREGALKAAPGSI---KQD-----EEKEKRVPGARGEP 595
Query: 556 LEEKLVEREKGTVIKPPVE-EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDT 614
L E+ G + K +E E ++ S +++E + + L + Q Q E+ L
Sbjct: 596 LGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGE----LGRERQRLQRELQSLSQR 651
Query: 615 LKSQMT--QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSL--ED 670
L+ + EA + + +++++ + +EL + +L K ++ R D
Sbjct: 652 LQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPAD 711
Query: 671 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI 730
+ E +++ + ++ + D E + +++ E QL+ + +E S+
Sbjct: 712 LVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSL 771
Query: 731 TEHLQ-VITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLE--EKAAMTDAMVPRS 787
+ L ++EE++ ++ ++ K E+ KL++ L + E+ A A S
Sbjct: 772 KAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAAS 831
Query: 788 --SYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 845
+EK + SL ++ +LK +++ EV ++R V++ +R ++ ++
Sbjct: 832 LRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAA--QAA 889
Query: 846 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 905
EQE +QA E +++ +++ L+E + I + K+KE L L QL
Sbjct: 890 EQE--------RQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL- 940
Query: 906 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKV 965
S+++ A++ + +L QL + +K H+E+IS YR HLL A +G M+ +V +
Sbjct: 941 ---------SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNI 991
Query: 966 LKQILTM 972
L QIL+M
Sbjct: 992 LLQILSM 998
Score = 32.0 bits (71), Expect = 2.9
Identities = 24/53 (45%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 9 RKSDTNEWNKND-DRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
R + N +KND L+ A E G AE VA LL GA A DS G A H A
Sbjct: 175 RGARVNVTDKNDKSALILACEKGSAE-VAELLLSHGADAGAVDSTGHDALHYA 226
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 139 bits (350), Expect = 1e-32
Identities = 205/941 (21%), Positives = 384/941 (40%), Gaps = 116/941 (12%)
Query: 22 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 81
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 136 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINI 195
Query: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
D + L A C LL+ D G TALHYA + L H
Sbjct: 196 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 255
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 256 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 315
Query: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS-----------KISQDADLKTP 250
L+++ ++ D G A Y+ + IQ +L +Q+ P
Sbjct: 316 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 375
Query: 251 TKPKQHDQVSKISSERSGTPKK---RKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFF 307
K+ + K+ + G + + A + S+ P+ S K+ F
Sbjct: 376 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQD--SQSYGKKKDEMF 433
Query: 308 AEPPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA 357
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 434 GNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVA 493
Query: 358 -------SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 410
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 494 QYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERK 548
Query: 411 SSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCL 469
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 549 DLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---AL 605
Query: 470 NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELR 526
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 606 REKTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIR 655
Query: 527 VTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSV 586
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 656 QRELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY--- 708
Query: 587 IENMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDEL 641
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 709 --NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDET 763
Query: 642 NKQVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT- 688
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 764 WTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTI 823
Query: 689 -----------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSI 730
N + K + ++K ++ ++ E + + V+ K+N V
Sbjct: 824 NMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLH 883
Query: 731 TEHLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDA 782
E L + L K +EEK+ NLK H+ VE+ K++ K L+E+A
Sbjct: 884 QELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIE 943
Query: 783 MVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLL 842
+ +K Q+ E ++ L S+K+KE +V + S++K E++ T L
Sbjct: 944 KLEEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTEL 999
Query: 843 KSKEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 882
+ ++ L+ E++ + K+ A S+KL +K++
Sbjct: 1000 EEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1040
Score = 56.2 bits (134), Expect = 1e-07
Identities = 114/579 (19%), Positives = 237/579 (40%), Gaps = 95/579 (16%)
Query: 439 QDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK-------ETQSK 491
++ Q+RLE SE ++ Q ++ E+ N + + + L ++L + K
Sbjct: 405 EEKQERLERSENKQPQDSQSYGKKKDEM--FGNFMLKRDIAMLKEELYAIKNDSLRKEKK 462
Query: 492 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD---LQNALEESER 548
Y + +K + + + + E M ++ +++N LK + L + LE+ +
Sbjct: 463 YIQEIKSITEINANFEKSVRLNEEMIT----KKVAQYSQQLNDLKAENARLNSKLEKEKH 518
Query: 549 NKEKVRELEEKLVEREKGTVIKPPVEEYEEM-----------KSSYCSVIENMNKEKAFL 597
NKE++ E L + + EY E+ ++ S E M + L
Sbjct: 519 NKERLEAEVESLHSN-----LATAINEYNEILERKDLELVLWRADDVSRHETMGSNISQL 573
Query: 598 FEKYQEAQEEIMKLK---DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLY 652
+K + E++ K + +TLK ++ T++A E E++ + + ++ E+ Q++
Sbjct: 574 TDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMH 633
Query: 653 -----KEAQA--------------ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA 693
KE+Q+ ELE+ + LED E +K + N+ R
Sbjct: 634 PNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEI------VINIHRD 687
Query: 694 KAEDALSEMKSQYSK-VLNELTQLKQ-LVDAQKENSV----------SITEHLQVITTLR 741
E+ ++ + +K ++NE LK+ L+ +KE + + +HL+ +
Sbjct: 688 CLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSE 747
Query: 742 TAAKEMEEKISNLKEHLASK----EVEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSS 795
+ + NL E SK +VE+ EK K +++ ++ + K
Sbjct: 748 SPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRE 807
Query: 796 LESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQ--------VKREKENIQTLLKSKEQ 847
LE E + L+ ++ +E +++ K+ K+ L+ KE
Sbjct: 808 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEA 867
Query: 848 EVNE---LLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 904
++ L + + +EL M + E KLE+DK ++ T +++ + L ++
Sbjct: 868 VSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKV 927
Query: 905 -SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 942
Y + +R Q +E L++ Q Q AE +KQ +++
Sbjct: 928 QEYKSELDERAMQAIEKLEEIHLQKQ---AEYEKQLEQL 963
Score = 44.3 bits (103), Expect = 6e-04
Identities = 72/433 (16%), Positives = 176/433 (40%), Gaps = 61/433 (14%)
Query: 529 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 588
++ I++ QD+ E +R ++++++E + + + +E + ++
Sbjct: 320 QQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLK 379
Query: 589 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS-- 646
K K K E +K+ K + + + ++ ++ + DE+
Sbjct: 380 KRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLK 439
Query: 647 -ELSQLYKEAQAELEDY--RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMK 703
+++ L +E A D +++K ++++ + A EK ++L E+ +++
Sbjct: 440 RDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLN-------EEMITKKV 492
Query: 704 SQYSKVLNEL----TQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 759
+QYS+ LN+L +L ++ +K N + +E ++ +L +LA
Sbjct: 493 AQYSQQLNDLKAENARLNSKLEKEKHNK-----------------ERLEAEVESLHSNLA 535
Query: 760 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 819
+ E ++LE K + ++ R+ ++ S +S L K E +
Sbjct: 536 TAINEY----NEILERKDL--ELVLWRADDVSRHETMGSNISQLTDK-------NELLTE 582
Query: 820 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 879
+V + R + + +K + + L+ K + + +QAQ + EMK+ + E
Sbjct: 583 QVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQ 642
Query: 880 KDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------------EALQQQV 925
K N S+E + +E N L + + + ++++ + L+++
Sbjct: 643 SIGKQNS-SEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 701
Query: 926 KQLQNQLAECKKQ 938
K+L N+ K++
Sbjct: 702 KELMNEYNYLKEK 714
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 139 bits (350), Expect = 1e-32
Identities = 205/941 (21%), Positives = 384/941 (40%), Gaps = 116/941 (12%)
Query: 22 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 81
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 165 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINI 224
Query: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
D + L A C LL+ D G TALHYA + L H
Sbjct: 225 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 284
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 285 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 344
Query: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS-----------KISQDADLKTP 250
L+++ ++ D G A Y+ + IQ +L +Q+ P
Sbjct: 345 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 404
Query: 251 TKPKQHDQVSKISSERSGTPKK---RKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFF 307
K+ + K+ + G + + A + S+ P+ S K+ F
Sbjct: 405 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQD--SQSYGKKKDEMF 462
Query: 308 AEPPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA 357
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 463 GNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVA 522
Query: 358 -------SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 410
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 523 QYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERK 577
Query: 411 SSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCL 469
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 578 DLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---AL 634
Query: 470 NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELR 526
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 635 REKTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIR 684
Query: 527 VTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSV 586
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 685 QRELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY--- 737
Query: 587 IENMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDEL 641
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 738 --NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDET 792
Query: 642 NKQVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT- 688
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 793 WTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTI 852
Query: 689 -----------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSI 730
N + K + ++K ++ ++ E + + V+ K+N V
Sbjct: 853 NMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLH 912
Query: 731 TEHLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDA 782
E L + L K +EEK+ NLK H+ VE+ K++ K L+E+A
Sbjct: 913 QELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIE 972
Query: 783 MVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLL 842
+ +K Q+ E ++ L S+K+KE +V + S++K E++ T L
Sbjct: 973 KLEEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTEL 1028
Query: 843 KSKEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 882
+ ++ L+ E++ + K+ A S+KL +K++
Sbjct: 1029 EEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1069
Score = 56.2 bits (134), Expect = 1e-07
Identities = 114/579 (19%), Positives = 237/579 (40%), Gaps = 95/579 (16%)
Query: 439 QDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK-------ETQSK 491
++ Q+RLE SE ++ Q ++ E+ N + + + L ++L + K
Sbjct: 434 EEKQERLERSENKQPQDSQSYGKKKDEM--FGNFMLKRDIAMLKEELYAIKNDSLRKEKK 491
Query: 492 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD---LQNALEESER 548
Y + +K + + + + E M ++ +++N LK + L + LE+ +
Sbjct: 492 YIQEIKSITEINANFEKSVRLNEEMIT----KKVAQYSQQLNDLKAENARLNSKLEKEKH 547
Query: 549 NKEKVRELEEKLVEREKGTVIKPPVEEYEEM-----------KSSYCSVIENMNKEKAFL 597
NKE++ E L + + EY E+ ++ S E M + L
Sbjct: 548 NKERLEAEVESLHSN-----LATAINEYNEILERKDLELVLWRADDVSRHETMGSNISQL 602
Query: 598 FEKYQEAQEEIMKLK---DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLY 652
+K + E++ K + +TLK ++ T++A E E++ + + ++ E+ Q++
Sbjct: 603 TDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMH 662
Query: 653 -----KEAQA--------------ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA 693
KE+Q+ ELE+ + LED E +K + N+ R
Sbjct: 663 PNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEI------VINIHRD 716
Query: 694 KAEDALSEMKSQYSK-VLNELTQLKQ-LVDAQKENSV----------SITEHLQVITTLR 741
E+ ++ + +K ++NE LK+ L+ +KE + + +HL+ +
Sbjct: 717 CLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSE 776
Query: 742 TAAKEMEEKISNLKEHLASK----EVEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSS 795
+ + NL E SK +VE+ EK K +++ ++ + K
Sbjct: 777 SPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRE 836
Query: 796 LESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQ--------VKREKENIQTLLKSKEQ 847
LE E + L+ ++ +E +++ K+ K+ L+ KE
Sbjct: 837 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEA 896
Query: 848 EVNE---LLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 904
++ L + + +EL M + E KLE+DK ++ T +++ + L ++
Sbjct: 897 VSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKV 956
Query: 905 -SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 942
Y + +R Q +E L++ Q Q AE +KQ +++
Sbjct: 957 QEYKSELDERAMQAIEKLEEIHLQKQ---AEYEKQLEQL 992
Score = 44.3 bits (103), Expect = 6e-04
Identities = 72/433 (16%), Positives = 176/433 (40%), Gaps = 61/433 (14%)
Query: 529 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 588
++ I++ QD+ E +R ++++++E + + + +E + ++
Sbjct: 349 QQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLK 408
Query: 589 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS-- 646
K K K E +K+ K + + + ++ ++ + DE+
Sbjct: 409 KRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLK 468
Query: 647 -ELSQLYKEAQAELEDY--RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMK 703
+++ L +E A D +++K ++++ + A EK ++L E+ +++
Sbjct: 469 RDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLN-------EEMITKKV 521
Query: 704 SQYSKVLNEL----TQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 759
+QYS+ LN+L +L ++ +K N + +E ++ +L +LA
Sbjct: 522 AQYSQQLNDLKAENARLNSKLEKEKHNK-----------------ERLEAEVESLHSNLA 564
Query: 760 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 819
+ E ++LE K + ++ R+ ++ S +S L K E +
Sbjct: 565 TAINEY----NEILERKDL--ELVLWRADDVSRHETMGSNISQLTDK-------NELLTE 611
Query: 820 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 879
+V + R + + +K + + L+ K + + +QAQ + EMK+ + E
Sbjct: 612 QVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQ 671
Query: 880 KDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------------EALQQQV 925
K N S+E + +E N L + + + ++++ + L+++
Sbjct: 672 SIGKQNS-SEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 730
Query: 926 KQLQNQLAECKKQ 938
K+L N+ K++
Sbjct: 731 KELMNEYNYLKEK 743
>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1139
Score = 139 bits (349), Expect = 2e-32
Identities = 205/941 (21%), Positives = 384/941 (40%), Gaps = 116/941 (12%)
Query: 22 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 81
++ +A GDA +V L ++ D + +T HLA A G V+ + +++ +
Sbjct: 165 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDRKDRTVLHLACAHGRVQVVTLLLDRKCQINI 224
Query: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
D + L A C LL+ D G TALHYA + L H
Sbjct: 225 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 284
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
+ I + +GN PLL A+ + + FLL + A++++ + RTAL+LA + S+ V
Sbjct: 285 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 344
Query: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS-----------KISQDADLKTP 250
L+++ ++ D G A Y+ + IQ +L +Q+ P
Sbjct: 345 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 404
Query: 251 TKPKQHDQVSKISSERSGTPKK---RKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFF 307
K+ + K+ + G + + A + S+ P+ S K+ F
Sbjct: 405 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQD--SQSYGKKKDEMF 462
Query: 308 AEPPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA 357
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 463 GNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVA 522
Query: 358 -------SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 410
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 523 QYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERK 577
Query: 411 SSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCL 469
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 578 DLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---AL 634
Query: 470 NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELR 526
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 635 REKTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIR 684
Query: 527 VTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSV 586
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 685 QRELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY--- 737
Query: 587 IENMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDEL 641
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 738 --NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDET 792
Query: 642 NKQVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT- 688
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 793 WTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTI 852
Query: 689 -----------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSI 730
N + K + ++K ++ ++ E + + V+ K+N V
Sbjct: 853 NMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLH 912
Query: 731 TEHLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDA 782
E L + L K +EEK+ NLK H+ VE+ K++ K L+E+A
Sbjct: 913 QELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIE 972
Query: 783 MVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLL 842
+ +K Q+ E ++ L S+K+KE +V + S++K E++ T L
Sbjct: 973 KLEEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTEL 1028
Query: 843 KSKEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 882
+ ++ L+ E++ + K+ A S+KL +K++
Sbjct: 1029 EEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1069
Score = 56.2 bits (134), Expect = 1e-07
Identities = 114/579 (19%), Positives = 237/579 (40%), Gaps = 95/579 (16%)
Query: 439 QDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK-------ETQSK 491
++ Q+RLE SE ++ Q ++ E+ N + + + L ++L + K
Sbjct: 434 EEKQERLERSENKQPQDSQSYGKKKDEM--FGNFMLKRDIAMLKEELYAIKNDSLRKEKK 491
Query: 492 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD---LQNALEESER 548
Y + +K + + + + E M ++ +++N LK + L + LE+ +
Sbjct: 492 YIQEIKSITEINANFEKSVRLNEEMIT----KKVAQYSQQLNDLKAENARLNSKLEKEKH 547
Query: 549 NKEKVRELEEKLVEREKGTVIKPPVEEYEEM-----------KSSYCSVIENMNKEKAFL 597
NKE++ E L + + EY E+ ++ S E M + L
Sbjct: 548 NKERLEAEVESLHSN-----LATAINEYNEILERKDLELVLWRADDVSRHETMGSNISQL 602
Query: 598 FEKYQEAQEEIMKLK---DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLY 652
+K + E++ K + +TLK ++ T++A E E++ + + ++ E+ Q++
Sbjct: 603 TDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMH 662
Query: 653 -----KEAQA--------------ELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA 693
KE+Q+ ELE+ + LED E +K + N+ R
Sbjct: 663 PNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEI------VINIHRD 716
Query: 694 KAEDALSEMKSQYSK-VLNELTQLKQ-LVDAQKENSV----------SITEHLQVITTLR 741
E+ ++ + +K ++NE LK+ L+ +KE + + +HL+ +
Sbjct: 717 CLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSE 776
Query: 742 TAAKEMEEKISNLKEHLASK----EVEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSS 795
+ + NL E SK +VE+ EK K +++ ++ + K
Sbjct: 777 SPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRE 836
Query: 796 LESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQ--------VKREKENIQTLLKSKEQ 847
LE E + L+ ++ +E +++ K+ K+ L+ KE
Sbjct: 837 LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEA 896
Query: 848 EVNE---LLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 904
++ L + + +EL M + E KLE+DK ++ T +++ + L ++
Sbjct: 897 VSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKV 956
Query: 905 -SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 942
Y + +R Q +E L++ Q Q AE +KQ +++
Sbjct: 957 QEYKSELDERAMQAIEKLEEIHLQKQ---AEYEKQLEQL 992
Score = 44.3 bits (103), Expect = 6e-04
Identities = 72/433 (16%), Positives = 176/433 (40%), Gaps = 61/433 (14%)
Query: 529 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 588
++ I++ QD+ E +R ++++++E + + + +E + ++
Sbjct: 349 QQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLK 408
Query: 589 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS-- 646
K K K E +K+ K + + + ++ ++ + DE+
Sbjct: 409 KRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLK 468
Query: 647 -ELSQLYKEAQAELEDY--RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMK 703
+++ L +E A D +++K ++++ + A EK ++L E+ +++
Sbjct: 469 RDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLN-------EEMITKKV 521
Query: 704 SQYSKVLNEL----TQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 759
+QYS+ LN+L +L ++ +K N + +E ++ +L +LA
Sbjct: 522 AQYSQQLNDLKAENARLNSKLEKEKHNK-----------------ERLEAEVESLHSNLA 564
Query: 760 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 819
+ E ++LE K + ++ R+ ++ S +S L K E +
Sbjct: 565 TAINEY----NEILERKDL--ELVLWRADDVSRHETMGSNISQLTDK-------NELLTE 611
Query: 820 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 879
+V + R + + +K + + L+ K + + +QAQ + EMK+ + E
Sbjct: 612 QVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQ 671
Query: 880 KDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------------EALQQQV 925
K N S+E + +E N L + + + ++++ + L+++
Sbjct: 672 SIGKQNS-SEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 730
Query: 926 KQLQNQLAECKKQ 938
K+L N+ K++
Sbjct: 731 KELMNEYNYLKEK 743
>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 132 bits (333), Expect = 1e-30
Identities = 208/957 (21%), Positives = 396/957 (41%), Gaps = 93/957 (9%)
Query: 12 DTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRV 71
D +W ++ +A GDA +V L ++ D + +T HLA A G V+ + +
Sbjct: 136 DIRDWELR--KIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTL 193
Query: 72 MITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGC 131
++ + D + L A + C LL+ D G TALHYA
Sbjct: 194 LLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKG 253
Query: 132 LQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALML 191
+ L H + I + +GN PLL A+ + + FLL + A++++ + RTAL+L
Sbjct: 254 TSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALIL 313
Query: 192 ACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL------------- 238
A + S+ V L+++ ++ D G A Y+ S+ I+ +L
Sbjct: 314 AVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRN 373
Query: 239 ----SKISQDADLKTPTKPKQHDQVSKISSERSGTPKKR---KAPPPPISPTQLSDVSSP 291
+ + A+LK + + + K++SE +R K P S + D
Sbjct: 374 DNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYG 433
Query: 292 RSITSTPLSGKESVFFA--------EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEA 343
+ ++ + +A E + EI SI E S + ++ + A
Sbjct: 434 NFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMI-TKTVA 492
Query: 344 DQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGE 403
L+ L+A+ A L N EL+ + K EAE +S HS+ L ++ + E
Sbjct: 493 RYSQQLNDLKAENARL---NSELEKEKHNKERLEAEV----ESLHSS---LATAINEYNE 542
Query: 404 TSPPDSKSSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSR 462
+ K VL + S + I QL + + L +++ + + L+ +L+
Sbjct: 543 I--VERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET 600
Query: 463 RAEL----VCLNNTEISENSSDLSQKLKETQSKYEEA-MKEVLSVQKQMKL-GLVSPESM 516
R L + L + ++ + ++KE + + KE S+ KQ L + + +
Sbjct: 601 RDALREKTLALGSVQLDLRQA--QHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQEL 658
Query: 517 DNYSHFHELRVTEEE-------INVLKQDLQNALEE--SERNKEKVRE---LEEKLVERE 564
+N +L +E IN+ + L+N E+ ERNKE ++E L+EKL++ E
Sbjct: 659 ENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCE 718
Query: 565 KGTVIKPP-VEEYEEMKSSYC---SVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMT 620
K + V E++E + S+ E+ + + E KL Q+
Sbjct: 719 KEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKL-----FQVE 773
Query: 621 QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAE 680
+ ++ E+ ++ + +I LN ++ + +E + E Y+K ++T ++
Sbjct: 774 IQPEEKHEEFRK-LFELISLLNYTADQIRKKNRELEEEATGYKK---CLEMTINMLNAFA 829
Query: 681 HEKLM--QLTNVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITEHLQV- 736
+E N + K + ++K +++ ++ E + + V+ K+N V E L +
Sbjct: 830 NEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMR 889
Query: 737 -----ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMVPRSSY 789
L K +EE++ NLK H+ VE+ KL+ K L+E+A +
Sbjct: 890 NVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHL 949
Query: 790 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-KEQE 848
+K Q+ E ++ L S+K+KE +V + S++K E + T L+ KE
Sbjct: 950 QK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEEVTTELEEFKEAF 1005
Query: 849 VNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 905
+ +++ + K+ A S+KL +K + +S T+ + L + L+
Sbjct: 1006 AGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLN 1062
Score = 45.1 bits (105), Expect = 3e-04
Identities = 78/395 (19%), Positives = 156/395 (39%), Gaps = 86/395 (21%)
Query: 621 QEASDEA--EDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHK 678
Q A D A D++ ++++ NK + + + A ++ +K E AE+ K
Sbjct: 341 QTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLK 400
Query: 679 -AEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-----ELTQLKQLVDAQKENSV---- 728
A EK +L + +D+ S K + + N ++ LK+ + A K +S+
Sbjct: 401 VASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 460
Query: 729 -------SITE-HLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
SITE + ++R K + + ++ + L + E A+L +L +EK
Sbjct: 461 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK---- 516
Query: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKE------------------SVKEKEKVHSEVV 822
+ E+L++ +ES S LA+ + E V EK+ S +
Sbjct: 517 ------HNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNIS 570
Query: 823 QIRSE----VSQVKREKENIQTLLKSKEQEVNELLQK-----------FQQAQEELAEMK 867
Q+ + QV + + TL K K +E + L++ +QAQ + EMK
Sbjct: 571 QLTDKNELLTEQVHKARVKFNTL-KGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMK 629
Query: 868 RYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------- 918
+ + E K N + + + + +E N L + + + ++++
Sbjct: 630 QMHPNGEAKESQSIGKQNSLEERI-RQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 688
Query: 919 ------------EALQQQVKQLQNQLAECKKQHQE 941
+ L ++ L+ +L +C+K+ E
Sbjct: 689 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAE 723
>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1002
Score = 132 bits (333), Expect = 1e-30
Identities = 204/934 (21%), Positives = 388/934 (41%), Gaps = 93/934 (9%)
Query: 12 DTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRV 71
D +W ++ +A GDA +V L ++ D + +T HLA A G V+ + +
Sbjct: 29 DIRDWELR--KIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTL 86
Query: 72 MITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGC 131
++ + D + L A + C LL+ D G TALHYA
Sbjct: 87 LLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKG 146
Query: 132 LQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALML 191
+ L H + I + +GN PLL A+ + + FLL + A++++ + RTAL+L
Sbjct: 147 TSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALIL 206
Query: 192 ACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL------------- 238
A + S+ V L+++ ++ D G A Y+ S+ I+ +L
Sbjct: 207 AVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRN 266
Query: 239 ----SKISQDADLKTPTKPKQHDQVSKISSERSGTPKKR---KAPPPPISPTQLSDVSSP 291
+ + A+LK + + + K++SE +R K P S + D
Sbjct: 267 DNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYG 326
Query: 292 RSITSTPLSGKESVFFA--------EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEA 343
+ ++ + +A E + EI SI E S + ++ + A
Sbjct: 327 NFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMI-TKTVA 385
Query: 344 DQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGE 403
L+ L+A+ A L N EL+ + K EAE +S HS+ L ++ + E
Sbjct: 386 RYSQQLNDLKAENARL---NSELEKEKHNKERLEAEV----ESLHSS---LATAINEYNE 435
Query: 404 TSPPDSKSSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSR 462
+ K VL + S + I QL + + L +++ + + L+ +L+
Sbjct: 436 I--VERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET 493
Query: 463 RAEL----VCLNNTEISENSSDLSQKLKETQSKYEEA-MKEVLSVQKQMKL-GLVSPESM 516
R L + L + ++ + ++KE + + KE S+ KQ L + + +
Sbjct: 494 RDALREKTLALGSVQLDLRQA--QHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQEL 551
Query: 517 DNYSHFHELRVTEEE-------INVLKQDLQNALEE--SERNKEKVRE---LEEKLVERE 564
+N +L +E IN+ + L+N E+ ERNKE ++E L+EKL++ E
Sbjct: 552 ENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCE 611
Query: 565 KGTVIKPP-VEEYEEMKSSYC---SVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMT 620
K + V E++E + S+ E+ + + E KL Q+
Sbjct: 612 KEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKL-----FQVE 666
Query: 621 QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAE 680
+ ++ E+ ++ + +I LN ++ + +E + E Y+K ++T ++
Sbjct: 667 IQPEEKHEEFRK-LFELISLLNYTADQIRKKNRELEEEATGYKK---CLEMTINMLNAFA 722
Query: 681 HEKLM--QLTNVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITEHLQV- 736
+E N + K + ++K +++ ++ E + + V+ K+N V E L +
Sbjct: 723 NEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMR 782
Query: 737 -----ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMVPRSSY 789
L K +EE++ NLK H+ VE+ KL+ K L+E+A +
Sbjct: 783 NVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHL 842
Query: 790 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-KEQE 848
+K Q+ E ++ L S+K+KE +V + S++K E + T L+ KE
Sbjct: 843 QK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEEVTTELEEFKEAF 898
Query: 849 VNELLQKFQQAQEELAEMKRYAESSSKLEEDKDK 882
+ +++ + K+ A S+KL +K++
Sbjct: 899 AGAVKANNSMSKKLMKSDKKIAVISTKLFMEKER 932
Score = 45.1 bits (105), Expect = 3e-04
Identities = 78/395 (19%), Positives = 156/395 (39%), Gaps = 86/395 (21%)
Query: 621 QEASDEA--EDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHK 678
Q A D A D++ ++++ NK + + + A ++ +K E AE+ K
Sbjct: 234 QTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLK 293
Query: 679 -AEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-----ELTQLKQLVDAQKENSV---- 728
A EK +L + +D+ S K + + N ++ LK+ + A K +S+
Sbjct: 294 VASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 353
Query: 729 -------SITE-HLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
SITE + ++R K + + ++ + L + E A+L +L +EK
Sbjct: 354 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK---- 409
Query: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKE------------------SVKEKEKVHSEVV 822
+ E+L++ +ES S LA+ + E V EK+ S +
Sbjct: 410 ------HNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNIS 463
Query: 823 QIRSE----VSQVKREKENIQTLLKSKEQEVNELLQK-----------FQQAQEELAEMK 867
Q+ + QV + + TL K K +E + L++ +QAQ + EMK
Sbjct: 464 QLTDKNELLTEQVHKARVKFNTL-KGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMK 522
Query: 868 RYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------- 918
+ + E K N + + + + +E N L + + + ++++
Sbjct: 523 QMHPNGEAKESQSIGKQNSLEERI-RQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 581
Query: 919 ------------EALQQQVKQLQNQLAECKKQHQE 941
+ L ++ L+ +L +C+K+ E
Sbjct: 582 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAE 616
>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 132 bits (333), Expect = 1e-30
Identities = 208/957 (21%), Positives = 396/957 (41%), Gaps = 93/957 (9%)
Query: 12 DTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRV 71
D +W ++ +A GDA +V L ++ D + +T HLA A G V+ + +
Sbjct: 136 DIRDWELR--KIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTL 193
Query: 72 MITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGC 131
++ + D + L A + C LL+ D G TALHYA
Sbjct: 194 LLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKG 253
Query: 132 LQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALML 191
+ L H + I + +GN PLL A+ + + FLL + A++++ + RTAL+L
Sbjct: 254 TSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALIL 313
Query: 192 ACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL------------- 238
A + S+ V L+++ ++ D G A Y+ S+ I+ +L
Sbjct: 314 AVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRN 373
Query: 239 ----SKISQDADLKTPTKPKQHDQVSKISSERSGTPKKR---KAPPPPISPTQLSDVSSP 291
+ + A+LK + + + K++SE +R K P S + D
Sbjct: 374 DNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYG 433
Query: 292 RSITSTPLSGKESVFFA--------EPPFKAEISSIRENKDRLSDSTTGADSLLDISSEA 343
+ ++ + +A E + EI SI E S + ++ + A
Sbjct: 434 NFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMI-TKTVA 492
Query: 344 DQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGE 403
L+ L+A+ A L N EL+ + K EAE +S HS+ L ++ + E
Sbjct: 493 RYSQQLNDLKAENARL---NSELEKEKHNKERLEAEV----ESLHSS---LATAINEYNE 542
Query: 404 TSPPDSKSSPSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSR 462
+ K VL + S + I QL + + L +++ + + L+ +L+
Sbjct: 543 I--VERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET 600
Query: 463 RAEL----VCLNNTEISENSSDLSQKLKETQSKYEEA-MKEVLSVQKQMKL-GLVSPESM 516
R L + L + ++ + ++KE + + KE S+ KQ L + + +
Sbjct: 601 RDALREKTLALGSVQLDLRQA--QHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQEL 658
Query: 517 DNYSHFHELRVTEEE-------INVLKQDLQNALEE--SERNKEKVRE---LEEKLVERE 564
+N +L +E IN+ + L+N E+ ERNKE ++E L+EKL++ E
Sbjct: 659 ENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCE 718
Query: 565 KGTVIKPP-VEEYEEMKSSYC---SVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMT 620
K + V E++E + S+ E+ + + E KL Q+
Sbjct: 719 KEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKL-----FQVE 773
Query: 621 QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAE 680
+ ++ E+ ++ + +I LN ++ + +E + E Y+K ++T ++
Sbjct: 774 IQPEEKHEEFRK-LFELISLLNYTADQIRKKNRELEEEATGYKK---CLEMTINMLNAFA 829
Query: 681 HEKLM--QLTNVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITEHLQV- 736
+E N + K + ++K +++ ++ E + + V+ K+N V E L +
Sbjct: 830 NEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMR 889
Query: 737 -----ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMVPRSSY 789
L K +EE++ NLK H+ VE+ KL+ K L+E+A +
Sbjct: 890 NVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHL 949
Query: 790 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-KEQE 848
+K Q+ E ++ L S+K+KE +V + S++K E + T L+ KE
Sbjct: 950 QK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEEVTTELEEFKEAF 1005
Query: 849 VNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 905
+ +++ + K+ A S+KL +K + +S T+ + L + L+
Sbjct: 1006 AGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLN 1062
Score = 45.1 bits (105), Expect = 3e-04
Identities = 78/395 (19%), Positives = 156/395 (39%), Gaps = 86/395 (21%)
Query: 621 QEASDEA--EDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHK 678
Q A D A D++ ++++ NK + + + A ++ +K E AE+ K
Sbjct: 341 QTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLK 400
Query: 679 -AEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-----ELTQLKQLVDAQKENSV---- 728
A EK +L + +D+ S K + + N ++ LK+ + A K +S+
Sbjct: 401 VASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 460
Query: 729 -------SITE-HLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
SITE + ++R K + + ++ + L + E A+L +L +EK
Sbjct: 461 KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK---- 516
Query: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKE------------------SVKEKEKVHSEVV 822
+ E+L++ +ES S LA+ + E V EK+ S +
Sbjct: 517 ------HNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNIS 570
Query: 823 QIRSE----VSQVKREKENIQTLLKSKEQEVNELLQK-----------FQQAQEELAEMK 867
Q+ + QV + + TL K K +E + L++ +QAQ + EMK
Sbjct: 571 QLTDKNELLTEQVHKARVKFNTL-KGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMK 629
Query: 868 RYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL--------- 918
+ + E K N + + + + +E N L + + + ++++
Sbjct: 630 QMHPNGEAKESQSIGKQNSLEERI-RQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 688
Query: 919 ------------EALQQQVKQLQNQLAECKKQHQE 941
+ L ++ L+ +L +C+K+ E
Sbjct: 689 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAE 723
>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
sapiens]
Length = 823
Score = 127 bits (318), Expect = 7e-29
Identities = 165/809 (20%), Positives = 321/809 (39%), Gaps = 104/809 (12%)
Query: 22 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 81
++ +A GDA +V L ++ D + +TA HLA A GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGELDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDV 95
Query: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 242
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 243 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 302
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 303 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 362
S+ +P + E +++ R + T A+ L ++SE +QQ
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQQ----------RHERSE 379
Query: 363 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 414
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 415 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 473
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 474 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 518
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 WDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 519 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 560
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 561 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 615
V+ E+ + + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTQDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD-- 676
Query: 616 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 661
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNNLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 662 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLKQ 718
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK+
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDFVLEEKSKKLMNECDHLKE 794
Query: 719 LVDAQKENSVSITEHLQVITTLRTAAKEM 747
+ + + ++ +T+ K++
Sbjct: 795 SLFQYEREKTEVVVSIKEDKYFQTSRKKI 823
Score = 43.5 bits (101), Expect = 0.001
Identities = 59/317 (18%), Positives = 128/317 (40%), Gaps = 30/317 (9%)
Query: 624 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 683
S E ED A+ + N Q Q A E + +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQQRHERSEKKQPQVKEGNNTNKSE 395
Query: 684 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 743
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 744 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 795
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDEN 514
Query: 796 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 850
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 851 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 902
E ++QQ +L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 903 QLSYSTSSSKRQSQQLE 919
L + ++ S Q+E
Sbjct: 629 NLKLALERTQDVSVQVE 645
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
sapiens]
Length = 823
Score = 126 bits (316), Expect = 1e-28
Identities = 170/808 (21%), Positives = 319/808 (39%), Gaps = 108/808 (13%)
Query: 22 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 81
++ +A GDA +V L ++ D + +TA HLA A GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDV 95
Query: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 242
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 243 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 302
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 303 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 362
S+ +P + E +++ R + T A+ L ++SE +Q+
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQE----------RHERSE 379
Query: 363 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 414
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 415 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 473
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 474 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 518
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 519 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 560
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 561 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 615
V+ E+ + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD-- 676
Query: 616 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 661
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 662 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLK- 717
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKE 794
Query: 718 ---QLVDAQKENSVSITEHLQVITTLRT 742
Q + E VSI E T+ +T
Sbjct: 795 SLFQYEREKTEGVVSIKEDKYFQTSRKT 822
Score = 43.1 bits (100), Expect = 0.001
Identities = 59/317 (18%), Positives = 128/317 (40%), Gaps = 30/317 (9%)
Query: 624 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 683
S E ED A+ + N Q Q A E ++ +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSE 395
Query: 684 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 743
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 744 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 795
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDEN 514
Query: 796 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 850
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 851 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 902
E ++QQ L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 903 QLSYSTSSSKRQSQQLE 919
L + ++ S Q+E
Sbjct: 629 NLKLALERTRDVSVQVE 645
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
sapiens]
Length = 823
Score = 124 bits (311), Expect = 4e-28
Identities = 168/798 (21%), Positives = 315/798 (39%), Gaps = 108/798 (13%)
Query: 22 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 81
++ +A GDA +V L ++ D + +TA HLA A GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDV 95
Query: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 242
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 243 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 302
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 303 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 362
S+ +P + E +++ R + T A+ L ++SE +Q+
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQE----------RHERSE 379
Query: 363 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 414
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 415 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 473
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 474 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 518
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 519 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 560
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 561 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 615
V+ E+ + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD-- 676
Query: 616 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 661
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 662 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLK- 717
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKE 794
Query: 718 ---QLVDAQKENSVSITE 732
Q + E VSI E
Sbjct: 795 SLFQYEREKTEGVVSIKE 812
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/317 (18%), Positives = 129/317 (40%), Gaps = 30/317 (9%)
Query: 624 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 683
S E ED A+ + N Q Q A E ++ +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSE 395
Query: 684 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 743
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 744 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 795
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDEN 514
Query: 796 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 850
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 851 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 902
E ++QQ +L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 903 QLSYSTSSSKRQSQQLE 919
L + ++ S Q+E
Sbjct: 629 NLKLALERTRDVSVQVE 645
>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
sapiens]
Length = 823
Score = 123 bits (309), Expect = 7e-28
Identities = 169/808 (20%), Positives = 318/808 (39%), Gaps = 108/808 (13%)
Query: 22 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 81
++ +A GDA +V L ++ D + +TA HLA GHV+ + +++ +
Sbjct: 36 KIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACTSGHVQVVTLLVNRKCQIDV 95
Query: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
D + L A C LL+ D G TALHYA + L H
Sbjct: 96 CDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSH 155
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
+ I D D N PLL A+ ++ FLL A ++ ++ R+ALMLA S V
Sbjct: 156 GAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIV 215
Query: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL-------------------SKIS 242
L+K+ D+ D G +A Y+ IQ +L S +S
Sbjct: 216 NILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVS 275
Query: 243 QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 302
+L+ + P D+ +++++ P+K P P S + + + + + P +
Sbjct: 276 IFHELRVDSLPASDDKDLNVATKQC-VPEKVSEPLPGSSHEKGNRIVNGQG--EGPPAKH 332
Query: 303 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLH 362
S+ +P + E +++ R + T A+ L ++SE +Q+
Sbjct: 333 PSL---KPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQE----------RHERSE 379
Query: 363 NKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKPGETSPPD-----SKSSPS 414
K+ Q K + K + LS + ST + L K G+T P +
Sbjct: 380 KKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDR 439
Query: 415 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTE- 473
+ + T+ ++ ++ +E L+ +K+ + E E KQL+ +QS + NT
Sbjct: 440 CTLKQENEEKTNVNMLYKKNREELERKEKQYK-KEVEAKQLEPTVQSLEMKSKTARNTPN 498
Query: 474 ------------ISEN---SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN 518
+ EN +D++ +E + + +++ K +K+ + +++
Sbjct: 499 WDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEK 558
Query: 519 YSHFHELRVTE------EEINVLKQDLQNALEESERNKEKVRELEEKL------------ 560
Y +E +TE +E+N LK + E + KE + LE +
Sbjct: 559 YIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAIS 618
Query: 561 -----VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL 615
V+ E+ + ++ S I + E FL E+ E Q + LKD
Sbjct: 619 KHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKAENEFLTEQLSETQIKFNALKD-- 676
Query: 616 KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-------------- 661
K + T+++ + E + + + +Q E+ ++Y+ A+A++ +
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICH 736
Query: 662 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQYSKVLNELTQLK- 717
R+ L + K +H+++ +TN+ R E + ++ + K++NE LK
Sbjct: 737 LQRENAWLVQQLDDVHQKEDHKEI--VTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKE 794
Query: 718 ---QLVDAQKENSVSITEHLQVITTLRT 742
Q + E VSI E T+ +T
Sbjct: 795 SLFQYEREKTEGVVSIKEDKYFQTSRKT 822
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/317 (18%), Positives = 129/317 (40%), Gaps = 30/317 (9%)
Query: 624 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 683
S E ED A+ + N Q Q A E ++ +R + + + +
Sbjct: 338 STEVED--PAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSE 395
Query: 684 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 743
+QL+ A + +Q K+ Q ++ + ++ + + T +
Sbjct: 396 KIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNML 455
Query: 744 AKEMEEKISNLKEHLASKEVEVAKLEKQL----LEEKAAMTDAMVPRSSYEKLQSS---- 795
K+ E++ KE KEVE +LE + ++ K A ++E+++
Sbjct: 456 YKKNREELER-KEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDEN 514
Query: 796 --LESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 850
L++++++L ++ K EKE + + ++I VK ++ +K E+ +
Sbjct: 515 CILKADIAILRQEICTMKNDNLEKENKYLKDIKI------VKETNAALEKYIKLNEEMIT 568
Query: 851 ELLQKFQQAQEEL--------AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 902
E ++QQ +L AE+ + ES +LE D + + ++ ++K E++ +
Sbjct: 569 ETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTER 628
Query: 903 QLSYSTSSSKRQSQQLE 919
L + ++ S Q+E
Sbjct: 629 NLKLALERTRDVSVQVE 645
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 117 bits (294), Expect = 4e-26
Identities = 154/733 (21%), Positives = 327/733 (44%), Gaps = 96/733 (13%)
Query: 320 RENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT--------LHNKELQDKLQ 371
R+ + L T + LD S A QQ+L S + +V L H ++Q+ Q
Sbjct: 1135 RDLGEELEALKTELEDTLD--STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 372 AKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRI 431
S E + + +L + + E + + VL+ G D++ +
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAK-QTLENERGELANEVKVLLQGKG----DSEHKR 1247
Query: 432 QQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLN---------NTEISENSSDLS 482
++++ LQ+LQ + E R +L ++ + EL + +++++++ S L
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 483 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEI--NVLKQ--- 537
+L++TQ +E ++ LS+ ++K + D + F E EEE N+ KQ
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLK------QVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361
Query: 538 ------DLQNALEESERNKEKVRELEEKLVEREKGTVIK--PPVEEYEEMKSSYCSVIEN 589
D++ +E+S E E++ KL + +G + V Y++++ + + +
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Query: 590 MN---------KEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKE------AM 634
++ ++ A EK Q+ ++++ + T+ ++ +E + +E ++
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL 1481
Query: 635 NRMIDELNKQVSELSQLYKEAQAELEDY---------------RKRKSLEDVTAEYIHKA 679
R ++E +Q +EL +L K+ + E+ED + +++LE E +
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541
Query: 680 EH-EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQL-----KQLVDAQKENSVSITEH 733
E E +Q T ++ + E L MK+Q+ + L + KQLV +E + +
Sbjct: 1542 EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE 1601
Query: 734 LQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQ 793
+ + A K++E + +L+ H+ S + KQL + +A M D M +L
Sbjct: 1602 RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM------RELD 1655
Query: 794 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELL 853
+ S +LA + KE+ K+ + + +E++Q++ E++ +R K Q + +++ +E+
Sbjct: 1656 DTRASREEILA-QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ---QERDELADEIA 1711
Query: 854 QKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKR 913
+ L E +R ++LEE+ +++ +LK+A + Q++ + +
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERS 1771
Query: 914 QSQQLEALQQQVKQLQNQLAECKKQHQE--VISVYRMHL--LYAVQGQMDEDVQKVLKQI 969
+Q+ E +QQ+++ QN+ + K Q E V S Y+ + L A Q++E + K+
Sbjct: 1772 HAQKNENARQQLER-QNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830
Query: 970 LTMCK--NQSQKK 980
CK +++KK
Sbjct: 1831 QAACKQVRRTEKK 1843
Score = 103 bits (256), Expect = 1e-21
Identities = 143/691 (20%), Positives = 304/691 (43%), Gaps = 106/691 (15%)
Query: 331 TGADSLLDISSE-----ADQQDLLSLLQAKVASL-------TLHNKELQDKLQAKSPKEA 378
T LL +S + A +++L+ + + ++A+ TL ++ + +KLQ + +A
Sbjct: 832 TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA 891
Query: 379 EADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQ--- 435
E +L ++ +L L K + H L + + R Q LQ
Sbjct: 892 ETELCAEA-----EELRARLTA--------KKQELEEICHDLEARVEEEEERCQHLQAEK 938
Query: 436 ----EILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI--SENSSDLSQKLKETQ 489
+ +Q+L+++LE E+ R++LQ+E + A+L L +I + + L+++ K +
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998
Query: 490 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 549
+ E + +++ K S+ + HE +T+ E + +++ Q E R
Sbjct: 999 DRIAEFTTNLTEEEEKSK-------SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 550 K---------EKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
K +++ EL+ ++ E +K + + EE + + +E +K +K
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAE------LKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 601 YQEAQEEIMKLKDTLKSQMT--QEASDEAEDMKEAMNRMIDELNKQV-SELSQLYKEAQA 657
+E + +I +L++ L+S+ +A + D+ E + + EL + S +Q ++
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 658 ELEDYRKRKSLEDVTAEY----------IHKAEHEKLMQLTNVSRAKA--EDALSEMKSQ 705
E E +K+LE+ + +A E QL R KA E A ++++
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 706 YSKVLNELTQL----------KQLVDAQ-KENSVSITEHLQVITTLRTAAKEMEEKISNL 754
++ NE+ L ++ V+AQ +E V E +V T L +++ ++ N+
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 755 KEHLASKEVEVAKLEKQL--LEEKAAMTDAMVPRSSYEKLQSS-----LESEVSVLASKL 807
L+ + + +KL K LE + T ++ + +KL S +E E + +L
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 808 KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQK-----FQQAQEE 862
+E + K + ++ + ++V+ +K++ E+ L++ E EV LQK Q+ +E+
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE-EVKRKLQKDLEGLSQRHEEK 1404
Query: 863 LAEMKRYAESSSKLEEDKDK---KINEMSKEVTKLKEALNSLSQL--SYSTSSSK----R 913
+A + ++ ++L+++ D ++ + L++ QL T S+K R
Sbjct: 1405 VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464
Query: 914 QSQQLEALQQQVK--QLQNQLAECKKQHQEV 942
+ EA +++ K L L E +Q E+
Sbjct: 1465 DRAEAEAREKETKALSLARALEEAMEQKAEL 1495
Score = 86.7 bits (213), Expect = 1e-16
Identities = 162/856 (18%), Positives = 338/856 (39%), Gaps = 151/856 (17%)
Query: 157 LLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDS 216
L ++ S+I D ++ SRNK+ + L E+ EAL + D +DS
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL------EALKTELEDT--LDS 1154
Query: 217 LGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAP 276
SK + I L + ++ + + ++H Q + +E+ K+ KA
Sbjct: 1155 TAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKAN 1214
Query: 277 PPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIR-----------ENKDR 325
T ++ + L GK +A++ ++ E D+
Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK 1274
Query: 326 LSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFD 385
++ D++ + S++D + S L ++L ++ Q+ LQ ++ ++
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKS--SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK 1332
Query: 386 SYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRL 445
+ L + E H+L K ++ +++ ++D L
Sbjct: 1333 QVEDEKNSFREQLEEEEEAK------------HNLEKQIATLHAQVADMKKKMEDSVGCL 1380
Query: 446 ESSEAERKQLQVELQ--SRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQ 503
E++E +++LQ +L+ S+R E ++ + + L Q+L + + + +++
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440
Query: 504 KQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEK-----VRELEE 558
K+ K F +L E+ I+ + ++ E R KE R LEE
Sbjct: 1441 KKQK-------------KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEE 1487
Query: 559 KLVER-EKGTVIKPPVEEYEEMKSSYCSV---IENMNKEKAFLFEKYQEAQEEIMKLKDT 614
+ ++ E + K E E++ SS V + + K K L ++ +E + ++ +L+D
Sbjct: 1488 AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE 1547
Query: 615 LKSQMTQEASDEAEDMKEAMNRMID--------ELNKQVSELSQLYKEAQAELEDYRKRK 666
L Q T++A E +AM + + ++ +L + +E +AELED RK++
Sbjct: 1548 L--QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605
Query: 667 S------------LEDVTA--EYIHKAEHEKLMQLTNV-------------SRAKAEDAL 699
S L+D+ A + +K E + QL + +RA E+ L
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 700 SEMKSQYSKVLN---ELTQLKQ----------------------LVDAQKENSVSITEHL 734
++ K K+ + E+ QL++ + ++ + ++++ E
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725
Query: 735 QVITTLRTAAKEMEEKISNL------------------------KEHLASKEVEVAKLEK 770
++ + +E+EE+ N + H E +LE+
Sbjct: 1726 RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER 1785
Query: 771 QLLEEKAAMTDAM-VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEV----VQIR 825
Q E K + + +S Y+ ++LE++++ L +L KE++ +V +++
Sbjct: 1786 QNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK 1845
Query: 826 SEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLE---EDKDK 882
+ QV E+ N + ++ L Q +Q +E E +R S KL+ ED +
Sbjct: 1846 DVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1905
Query: 883 KINEMSKEVTKLKEAL 898
+ M++EV+ LK L
Sbjct: 1906 TADAMNREVSSLKNKL 1921
Score = 81.3 bits (199), Expect = 4e-15
Identities = 105/586 (17%), Positives = 246/586 (41%), Gaps = 63/586 (10%)
Query: 314 AEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNK-------EL 366
A + + K RL D L+D+ + L Q K L K E
Sbjct: 1406 AAYDKLEKTKTRLQQELD--DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 367 QDKLQAKSPKEAEADLSF----DSYHSTQTDLGPSLGKPGETSPPD---SKSSPSVLIHS 419
+D+ +A++ ++ LS + + +L L K T D SK +H
Sbjct: 1464 RDRAEAEAREKETKALSLARALEEAMEQKAEL-ERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 420 LGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS 479
L KS + ++++++ L++L+ L+++E + +L+V LQ+ +A+ ++
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF----ERDLQGRDE 1578
Query: 480 DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDL 539
+K K+ + E E+ +KQ + + + + ++ +L+ E I+ ++
Sbjct: 1579 QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM-----DLKDLEAHIDSANKNR 1633
Query: 540 QNALEESER----NKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA 595
A+++ + K+ +REL++ RE+ ++ E +++KS +I+ + +E A
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREE--ILAQAKENEKKLKSMEAEMIQ-LQEELA 1690
Query: 596 FLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEA 655
++AQ+E +D L ++ + A ++E L ++++L + +E
Sbjct: 1691 AAERAKRQAQQE----RDELADEIANSSGKGALALEEKRR-----LEARIAQLEEELEEE 1741
Query: 656 QAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQ 715
Q E R ++ + I+ + L K E+A +++ Q ++ +L +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTD-----LNLERSHAQKNENARQQLERQNKELKVKLQE 1796
Query: 716 LKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEE 775
++ V ++ + S++ +E KI+ L+E L ++ E KQ+
Sbjct: 1797 MEGTVKSKYKASITA----------------LEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 776 KAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREK 835
+ + D ++ + + + +++LK+ ++ E+ E + + +++RE
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 836 ENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKD 881
E+ + +EV+ L K ++ +R A + D++
Sbjct: 1901 EDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEE 1946
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 117 bits (293), Expect = 5e-26
Identities = 70/209 (33%), Positives = 104/209 (49%), Gaps = 1/209 (0%)
Query: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
N LL A G A V +LL GA+ DSEG+T +A+A+G+VE +R ++ G
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFW-GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
Query: 77 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136
+D +D G + LH+AA H L++ +D+ G+ A+ +G VQ
Sbjct: 838 LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
Query: 137 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIG 196
IL E+KS I+ + DG L +A GH +I L HGADVN ++ GR L +
Sbjct: 898 ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
Query: 197 SSNAVEALIKKGADLNLVDSLGYNALHYS 225
E ++ GA++ D+ G ALH S
Sbjct: 958 QLTMAEYFLENGANVEASDAEGRTALHVS 986
Score = 115 bits (288), Expect = 2e-25
Identities = 104/397 (26%), Positives = 178/397 (44%), Gaps = 28/397 (7%)
Query: 13 TNEWNKNDDRL--LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
TNE + ND R+ + A + G + V LL K ++ + +G+ A +AA +GH + +
Sbjct: 873 TNEID-NDGRIPFILASQEGHYDCVQILLENK-SNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
++ +HG DV +D G L++ A + L++ E+ D+ G+TALH + QG
Sbjct: 931 LLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG 990
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 190
++ VQ+L + + +N D + L A GH ++ L++HGA V+ G TAL
Sbjct: 991 HMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALC 1050
Query: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL--LSKISQDADLK 248
+A + G + V+ L++ GAD N D G A+ + + ++ I LL S +
Sbjct: 1051 IAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSP 1110
Query: 249 TPTKPKQHDQVSKISSE-RSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFF 307
+P + + +SS+ +S T K + Q S R + + P S
Sbjct: 1111 SPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQ----PSLRGLPNGPTHAFSS--- 1163
Query: 308 AEPPFKAEISSIRENKDRLSDSTTGA---DSLLDISSEADQQDLLSLLQAKVASLTLHNK 364
P ++ S++ K LS+++ + SL SS A Q V + HN
Sbjct: 1164 ---PSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQ--------TVPIDSFHNL 1212
Query: 365 ELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKP 401
+++Q S + + S S ST LG S P
Sbjct: 1213 SFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSP 1249
Score = 111 bits (278), Expect = 3e-24
Identities = 74/233 (31%), Positives = 110/233 (47%), Gaps = 5/233 (2%)
Query: 11 SDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
+ N+ + N LL + V +LL +GA D+ G T LAA +GH + +
Sbjct: 536 ASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVN 595
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
+I G ++ D G +AL AA H E + LL + + D+ +TAL AA G
Sbjct: 596 CLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGG 655
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 190
V L +H + +N D +G L+ A GH EI LLDHGA+VN + GRTAL
Sbjct: 656 HEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALS 715
Query: 191 LA-----CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
+A G ++ V LI +GA+++ D G L + + + LLL
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLL 768
Score = 110 bits (276), Expect = 5e-24
Identities = 81/247 (32%), Positives = 120/247 (48%), Gaps = 16/247 (6%)
Query: 17 NKNDDR----LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVM 72
N DDR + QA+E D+ + +LL GAS + DS G+T AA G ++ + ++
Sbjct: 508 NSEDDRTSCIVRQALEREDS--IRTLLDN-GASVNQCDSNGRTLLANAAYSGSLDVVNLL 564
Query: 73 ITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCL 132
++ G D+ +D GH+ L LAA+ H + + L+ D G TAL AA G
Sbjct: 565 VSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHT 624
Query: 133 QAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLA 192
+ V L ++ D D L A GH +I LL HGA+VN + GRTAL+ A
Sbjct: 625 EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAA 684
Query: 193 CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL-----SENAGIQSLLLSKISQ---- 243
+G VE L+ GA++N D G AL + L +A + SLL+ + ++
Sbjct: 685 AYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHC 744
Query: 244 DADLKTP 250
D D TP
Sbjct: 745 DKDGMTP 751
Score = 109 bits (273), Expect = 1e-23
Identities = 73/240 (30%), Positives = 113/240 (47%), Gaps = 10/240 (4%)
Query: 6 AKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH 65
A +D + W L A G E V++LL G D++ +TA AA GH
Sbjct: 602 ANINHTDQDGWTA----LRSAAWGGHTEVVSALL-YAGVKVDCADADSRTALRAAAWGGH 656
Query: 66 VECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHY 125
+ + ++ HG +V D G +AL AA H E + LL D G+TAL
Sbjct: 657 EDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 716
Query: 126 AA-----AQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
AA ++G V +L + + ++ D DG PLL+A GH ++ LL+ GADV+
Sbjct: 717 AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
+ +GRT L+ A +G ++ V L+ GA ++ +DS G L + N + LL +
Sbjct: 777 TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Score = 108 bits (271), Expect = 2e-23
Identities = 68/205 (33%), Positives = 100/205 (48%), Gaps = 5/205 (2%)
Query: 24 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 83
L+A G E + L + GA K D+EG+TA AA GH E + ++ HG +V +D
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707
Query: 84 TTGHSALHLAA-----KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
G +AL +AA H + L+ + D G T L AA +G + V +L
Sbjct: 708 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 767
Query: 139 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSS 198
E + ++ D +G PLL A GH+ + + LL GA V+S + GRT L +A G+
Sbjct: 768 LEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNV 827
Query: 199 NAVEALIKKGADLNLVDSLGYNALH 223
V L+ +G D N D G+ LH
Sbjct: 828 EVVRTLLDRGLDENHRDDAGWTPLH 852
Score = 106 bits (264), Expect = 1e-22
Identities = 67/205 (32%), Positives = 103/205 (50%)
Query: 35 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAA 94
V SLL +GA D +G T +AA +GHV+ + +++ G DV D G + L AA
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
Query: 95 KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNI 154
H + LL +S+DS G+T L A+AQG ++ V+ L + N +D G
Sbjct: 790 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWT 849
Query: 155 PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLV 214
PL +A GH IC L++ GA N + GR +LA + G + V+ L++ ++++
Sbjct: 850 PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQR 909
Query: 215 DSLGYNALHYSKLSENAGIQSLLLS 239
G NAL + L + I LL S
Sbjct: 910 GYDGRNALRVAALEGHRDIVELLFS 934
Score = 104 bits (259), Expect = 5e-22
Identities = 63/213 (29%), Positives = 102/213 (47%), Gaps = 1/213 (0%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
A G+ E V +LL + G D G T H+AA +GH +I G D
Sbjct: 821 ASAQGNVEVVRTLLDR-GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 879
Query: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 145
G LA++ H++C++ LL++K + G+ AL AA +G V++L H + +
Sbjct: 880 GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
Query: 146 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 205
N KD DG L + + + L++GA+V + + GRTAL ++C G V+ LI
Sbjct: 940 NCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLI 999
Query: 206 KKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
AD+N D+ +AL + + + LL+
Sbjct: 1000 AYHADVNAADNEKRSALQSAAWQGHVKVVQLLI 1032
Score = 102 bits (254), Expect = 2e-21
Identities = 66/201 (32%), Positives = 98/201 (48%), Gaps = 1/201 (0%)
Query: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
LL A G + V LL + GA D+ G+T AA+ GH + ++ G V +
Sbjct: 752 LLVAAYEGHVD-VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
Query: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHK 142
D+ G + L +A+ + E +R LL D +G T LH AA +G + L E
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 143 SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVE 202
+ N D DG IP +LA Q GH + LL++ ++++ R GR AL +A G + VE
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 203 ALIKKGADLNLVDSLGYNALH 223
L GAD+N D+ G L+
Sbjct: 931 LLFSHGADVNCKDADGRPTLY 951
Score = 93.2 bits (230), Expect = 1e-18
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 10/218 (4%)
Query: 6 AKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAA---- 61
A+ K+D N+ L+ A G E V LL GA D +G+TA +AA
Sbjct: 668 AEVNKAD----NEGRTALIAAAYMGHREIVEHLLDH-GAEVNHEDVDGRTALSVAALCVP 722
Query: 62 -AKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
+KGH + ++I G +V D G + L +AA H + + LL+ + D++G+
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
T L AA+ G V L + ++ D +G L +A G+ E+ LLD G D N
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLG 218
R+ +G T L +A G EALI++GA N +D+ G
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Score = 58.5 bits (140), Expect = 3e-08
Identities = 35/114 (30%), Positives = 58/114 (50%), Gaps = 2/114 (1%)
Query: 11 SDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
+D N + LQ+ KV LL + GA ++G TA +AA +GH++ ++
Sbjct: 1003 ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQ 1062
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALH 124
V++ HG D D G +A+ +AAKN H + I+ L K A S++ + +H
Sbjct: 1063 VLLEHGADPNHADQFGRTAMRVAAKNGHSQIIK--LLEKYGASSLNGCSPSPVH 1114
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 117 bits (292), Expect = 7e-26
Identities = 165/745 (22%), Positives = 321/745 (43%), Gaps = 121/745 (16%)
Query: 301 GKESVFFAEPPFKAEISSIR-------ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 353
G E+ FAE K +I +R EN DS A + EA + L+ +++
Sbjct: 604 GTETAEFAE--LKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---EMEALRAKLMKVIK 658
Query: 354 AKVASLTL-----------HNKELQD---KLQAKSPKEAEADLSFDSYHSTQTDLGPSLG 399
K SL H E++D KLQ K E ++ + + QT + +
Sbjct: 659 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNF- 716
Query: 400 KPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERK------ 453
TS + + + +L K++++ +++L++ L+ +K+++ E E+
Sbjct: 717 ----TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 772
Query: 454 -QLQVELQSRRAELVCL--NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGL 510
+ ELQ R +L L N +E+S+ L ++L+ + K+ EA +E +SVQ+ M+
Sbjct: 773 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ--- 829
Query: 511 VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTV-I 569
++L EE+ N+L DL+ E + K RE +E+ + K +
Sbjct: 830 ---------ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 880
Query: 570 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD------------TLKS 617
+ + E +M S + MN E +E Q ++ K + T+K+
Sbjct: 881 ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKA 940
Query: 618 QMTQ-EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 676
+ +Q EA+ + E+ K+ + R + +L K++ +E +A E T+E
Sbjct: 941 EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER---------ATSET- 990
Query: 677 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQK-----ENSVSIT 731
K +HE+++Q + ED L + + S +L EL +L++ D K E+++ I
Sbjct: 991 -KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1049
Query: 732 EHLQVITTLRTAAKE--------MEEKISNLKEHLA------SKEVEVAKLEKQLLEEKA 777
E + T A+ E ++ ++ LKE+ +K E+ +E Q +EE
Sbjct: 1050 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109
Query: 778 AMTDAMVPRSSYEKLQ-SSLESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKR 833
+ + ++ + Q S+L+ E LA +L ++ V +K+ E + +++ ++K+
Sbjct: 1110 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1169
Query: 834 -----------EKENIQ-------TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSK 875
EK ++Q LL K+ E+ +L + + E A K
Sbjct: 1170 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1229
Query: 876 LEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 935
LE DK K ++ +LKE LS S +T + + ++ A + Q+ L + + +
Sbjct: 1230 LESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDER--AQESQIDFLNSVIVDL 1287
Query: 936 KKQHQEVISVYRMHLLYAVQGQMDE 960
++++Q++ M A+ G D+
Sbjct: 1288 QRKNQDLKMKVEMMSEAALNGNGDD 1312
Score = 92.8 bits (229), Expect = 1e-18
Identities = 144/694 (20%), Positives = 295/694 (42%), Gaps = 77/694 (11%)
Query: 267 SGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRL 326
S TP K KA S S RS +++ LS SV + + + E R
Sbjct: 285 STTPAKAKANAVRRVMATTS-ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 327 SDSTTGADSLLDISSEADQ--QDLLS---LLQAKVASLTLHNKELQDKL--------QAK 373
+ +G +L + E Q + LL+ L +A+VA T H E++ +L Q
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV 403
Query: 374 SPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQ 433
EA+ D + + L + E + + + +S T D+ +
Sbjct: 404 LELEAKMDQLRTMVEAADREKVELLNQLEE----EKRKVEDLQFRVEEESITKGDLEVAT 459
Query: 434 LQEI--LQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSK 491
+ E + +L+K L E +L+ L+S + + + + S L +KL+ T++
Sbjct: 460 VSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTD 519
Query: 492 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE 551
++ +E+ S+++ + L E+++ + L++ LE + +
Sbjct: 520 HQ---REITSLKEHF-----GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 571
Query: 552 KVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKL 611
V L + +E T I + EE+K S+ + E A L + ++ + +
Sbjct: 572 DVIALWKSKLE----TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE 627
Query: 612 KDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDV 671
+ L++Q E + A++M EA+ ++L ++ KE + LE R +
Sbjct: 628 IENLQNQQDSERAAHAKEM-EALR----------AKLMKVIKEKENSLEAIRSK------ 670
Query: 672 TAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-ELTQLK-----QLVDAQKE 725
+ KAE + L+++ ED L++++ KV E+ Q K +++D
Sbjct: 671 ----LDKAEDQHLVEM--------EDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 718
Query: 726 NSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP 785
+ E L + LR A+ E + ++ L++ L + E ++ LE + E + +
Sbjct: 719 QLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRE 778
Query: 786 RSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS 844
E ++L+ +S + S++KE++ KE + + + + E V+R + L
Sbjct: 779 LQGRELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
Query: 845 KEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL 904
KE++ N L ++ +E LA+M+ +K E KD++ ++ K KL+ + + ++
Sbjct: 838 KEEQFNMLSSDLEKLRENLADME------AKFRE-KDEREEQLIKAKEKLENDIAEIMKM 890
Query: 905 SYSTSSS-KRQSQQLEALQQQVKQLQNQLAECKK 937
S SS + + +L ++ V++LQ +L + +
Sbjct: 891 SGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 924
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 117 bits (292), Expect = 7e-26
Identities = 165/745 (22%), Positives = 321/745 (43%), Gaps = 121/745 (16%)
Query: 301 GKESVFFAEPPFKAEISSIR-------ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQ 353
G E+ FAE K +I +R EN DS A + EA + L+ +++
Sbjct: 639 GTETAEFAE--LKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---EMEALRAKLMKVIK 693
Query: 354 AKVASLTL-----------HNKELQD---KLQAKSPKEAEADLSFDSYHSTQTDLGPSLG 399
K SL H E++D KLQ K E ++ + + QT + +
Sbjct: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNF- 751
Query: 400 KPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERK------ 453
TS + + + +L K++++ +++L++ L+ +K+++ E E+
Sbjct: 752 ----TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 807
Query: 454 -QLQVELQSRRAELVCL--NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGL 510
+ ELQ R +L L N +E+S+ L ++L+ + K+ EA +E +SVQ+ M+
Sbjct: 808 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ--- 864
Query: 511 VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTV-I 569
++L EE+ N+L DL+ E + K RE +E+ + K +
Sbjct: 865 ---------ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 915
Query: 570 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD------------TLKS 617
+ + E +M S + MN E +E Q ++ K + T+K+
Sbjct: 916 ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKA 975
Query: 618 QMTQ-EASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 676
+ +Q EA+ + E+ K+ + R + +L K++ +E +A E T+E
Sbjct: 976 EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER---------ATSET- 1025
Query: 677 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQK-----ENSVSIT 731
K +HE+++Q + ED L + + S +L EL +L++ D K E+++ I
Sbjct: 1026 -KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1084
Query: 732 EHLQVITTLRTAAKE--------MEEKISNLKEHLA------SKEVEVAKLEKQLLEEKA 777
E + T A+ E ++ ++ LKE+ +K E+ +E Q +EE
Sbjct: 1085 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1144
Query: 778 AMTDAMVPRSSYEKLQ-SSLESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKR 833
+ + ++ + Q S+L+ E LA +L ++ V +K+ E + +++ ++K+
Sbjct: 1145 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1204
Query: 834 -----------EKENIQ-------TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSK 875
EK ++Q LL K+ E+ +L + + E A K
Sbjct: 1205 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1264
Query: 876 LEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 935
LE DK K ++ +LKE LS S +T + + ++ A + Q+ L + + +
Sbjct: 1265 LESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDER--AQESQIDFLNSVIVDL 1322
Query: 936 KKQHQEVISVYRMHLLYAVQGQMDE 960
++++Q++ M A+ G D+
Sbjct: 1323 QRKNQDLKMKVEMMSEAALNGNGDD 1347
Score = 91.7 bits (226), Expect = 3e-18
Identities = 144/714 (20%), Positives = 299/714 (41%), Gaps = 82/714 (11%)
Query: 267 SGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRL 326
S TP K KA S S RS +++ LS SV + + + E R
Sbjct: 285 STTPAKAKANAVRRVMATTS-ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 327 SDSTTGADSLLDISSEADQ--QDLLS---LLQAKVASLTLHNKELQDKL--------QAK 373
+ +G +L + E Q + LL+ L +A+VA T H E++ +L Q
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV 403
Query: 374 SPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQ 433
EA+ D + + L + E V S+ K + +++
Sbjct: 404 LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEH 463
Query: 434 LQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYE 493
+ +++L++ L + + +LQ EL+ R V + I E DL+ +++E
Sbjct: 464 AR--IKELEQSLLFEKTKADKLQRELEDTRVATVS-EKSRIMELEKDLALRVQE------ 514
Query: 494 EAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKV 553
V ++++++ + + + S E+ +E++ V + D Q + + +
Sbjct: 515 -----VAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR 569
Query: 554 RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFE-----------KYQ 602
E +K ++ + E+ + S S +E+ NKE + + +Q
Sbjct: 570 EETHQKEIK-----ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ 624
Query: 603 EAQEEIMKLKDT-----------LKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQL 651
+A EE+ LK+Q+ + D +++ N+ E E+ L
Sbjct: 625 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 684
Query: 652 YKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN 711
+ +++ K SLE + ++ + KAE + L+++ ED L++++ KV
Sbjct: 685 RAKLMKVIKE--KENSLEAIRSK-LDKAEDQHLVEM--------EDTLNKLQEAEIKVKE 733
Query: 712 -ELTQLK-----QLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEV 765
E+ Q K +++D + E L + LR A+ E + ++ L++ L + E ++
Sbjct: 734 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 793
Query: 766 AKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQI 824
LE + E + + E ++L+ +S + S++KE++ KE + + + +
Sbjct: 794 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEA 852
Query: 825 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 884
E V+R + L KE++ N L ++ +E LA+M+ +K E KD++
Sbjct: 853 SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADME------AKFRE-KDERE 905
Query: 885 NEMSKEVTKLKEALNSLSQLSYSTSSS-KRQSQQLEALQQQVKQLQNQLAECKK 937
++ K KL+ + + ++S SS + + +L ++ V++LQ +L + +
Sbjct: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 959
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/302 (19%), Positives = 128/302 (42%), Gaps = 47/302 (15%)
Query: 691 SRAKAEDALSEMKSQYSKVLNELTQLKQLV--------------DAQKENSVSITEHLQV 736
SR L+E S+Y++ ++ T L++ + D ++ T H+
Sbjct: 328 SRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGE 387
Query: 737 ITTLRTAAK--------EMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSS 788
I A+ E+E K+ L+ + + + E +L QL EEK + D
Sbjct: 388 IEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE 447
Query: 789 YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQE 848
+ LE++ + +++KE + ++ +++ +++RE E+ + S++
Sbjct: 448 ESITKGDLETQTKLEHARIKE-------LEQSLLFEKTKADKLQRELEDTRVATVSEKSR 500
Query: 849 VNELLQKFQQAQEELAEMKRYAESS----------------SKLEEDKDKKINEMSKEVT 892
+ EL + +E+AE++R ES+ S L+E + + +E+T
Sbjct: 501 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 560
Query: 893 KLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLY 952
LKE + + K E L ++ + L+++L K++ +VI++++ L
Sbjct: 561 SLKEHFGAREET--HQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 618
Query: 953 AV 954
A+
Sbjct: 619 AI 620
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 116 bits (291), Expect = 9e-26
Identities = 70/218 (32%), Positives = 104/218 (47%)
Query: 32 AEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALH 91
+E+ +L K A D +T H+AAA V+C V+I V D G +ALH
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 92 LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLD 151
AA N H E + LL + D + ALH+AA G L V +L H + + KD
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Query: 152 GNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 211
G PL A NG + LL+ G +++ N G TAL +AC G V LI GA++
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 212 NLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
N ++ G+ LH++ S + + LL D ++++
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Score = 105 bits (261), Expect = 3e-22
Identities = 64/194 (32%), Positives = 95/194 (48%), Gaps = 1/194 (0%)
Query: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 89
GDAE + LL GA D+ T H A A E ++V+I H DV A+D +
Sbjct: 27 GDAE-IIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTP 85
Query: 90 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
LH+AA N +C ++ D G+TALH+AA G ++ V +L + IN D
Sbjct: 86 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 145
Query: 150 LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
L A GH ++ L++HGA+V ++K G T L A G N V+ L+ G
Sbjct: 146 KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGV 205
Query: 210 DLNLVDSLGYNALH 223
+++ ++ G ALH
Sbjct: 206 EIDEINVYGNTALH 219
Score = 102 bits (254), Expect = 2e-21
Identities = 67/214 (31%), Positives = 101/214 (47%), Gaps = 1/214 (0%)
Query: 11 SDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
+D N +KN L A K A ++ +S D G+TA H AA GHVE +
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN 132
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
+++ G ++ A D ALH AA H + + L+ D G T LH AA+ G
Sbjct: 133 LLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL- 189
+ V+ L I+ ++ GN L +A NG + + L+D+GA+VN N +G T L
Sbjct: 193 QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLH 252
Query: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
A + +E L+ GAD+N+ G + LH
Sbjct: 253 FAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286
Score = 101 bits (251), Expect = 4e-21
Identities = 59/190 (31%), Positives = 95/190 (50%)
Query: 50 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 109
DSE +T H+AA G E + ++I G V A+D + LH A + E ++ L++
Sbjct: 13 DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
Query: 110 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 169
+ D + +T LH AAA ++ +++ S +N+ D G L A NGH E+ +
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN 132
Query: 170 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 229
LL GA++N+ +K R AL A +G + V LI GA++ D GY LH + +
Sbjct: 133 LLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192
Query: 230 NAGIQSLLLS 239
+ LL+
Sbjct: 193 QINVVKHLLN 202
Score = 96.7 bits (239), Expect = 1e-19
Identities = 66/219 (30%), Positives = 98/219 (44%), Gaps = 28/219 (12%)
Query: 50 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 109
D +G T H+AA GH + + T G D LHLAA N+H +C RKLL S
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG 370
Query: 110 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 169
++ D G+T LH AAA G ++ +++L + + KD G PL A N H
Sbjct: 371 FEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIE 430
Query: 170 FLLDHGADVNSRNKSGRTALMLAC----------------------------EIGSSNAV 201
L+ GA+VN + GRTAL A E ++ +
Sbjct: 431 TLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCL 490
Query: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
E L++ A+ ++ D GYN++HY+ + LLL +
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER 529
Score = 94.0 bits (232), Expect = 6e-19
Identities = 75/269 (27%), Positives = 116/269 (43%), Gaps = 41/269 (15%)
Query: 19 NDDRLLQAVENGDAEKVASL--LGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
N + L +A E + E L L + A+ + D EG + H AAA GH +CL +++
Sbjct: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 77 VDVTAQDTTG--HSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG---- 130
+ +G S LHLAA N HH+ + LLQS + D G+TAL AA +G
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
Query: 131 ---------------------------------CLQAVQILCEHKSPINLKDLDGNIPLL 157
CL+ + + ++ +++KD G PL+
Sbjct: 591 VEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLM 650
Query: 158 LAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL 217
LAV GH + LL+ A+V++ + G TAL G V+ L+++ + DS
Sbjct: 651 LAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR 710
Query: 218 GYNALHYSKLSENAGIQSLLLSKISQDAD 246
G LHY+ +A S LL + D
Sbjct: 711 GRTPLHYAAARGHATWLSELLQMALSEED 739
Score = 89.0 bits (219), Expect = 2e-17
Identities = 73/266 (27%), Positives = 112/266 (42%), Gaps = 35/266 (13%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH-VECLRVMITHGVDVTAQDT 84
A NG V L+ GA+ + ++ G T H AAA H CL +++ +G DV Q
Sbjct: 221 ACYNGQDAVVNELIDY-GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK 279
Query: 85 TGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 144
G S LH+ A + + L+Q+ + VD G T LH AA G + L +
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Query: 145 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIG-------- 196
+ PL LA N HS+ C LL G ++++ +K GRT L A G
Sbjct: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Query: 197 -SSNA------------------------VEALIKKGADLNLVDSLGYNALHYSKLSENA 231
SS A +E L+ GA++N D G ALHY+ S+
Sbjct: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMD 459
Query: 232 GIQSLLLSKISQDADLKTPTKPKQHD 257
+++L + +L+ + K+ +
Sbjct: 460 RNKTILGNAHDNSEELERARELKEKE 485
Score = 87.4 bits (215), Expect = 6e-17
Identities = 64/234 (27%), Positives = 93/234 (39%), Gaps = 35/234 (14%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
A NG V LL G + + G TA H+A G + +I +G +V +
Sbjct: 188 AASNGQINVVKHLLNL-GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246
Query: 86 GHSALHLAAKNSHHE-CIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 144
G + LH AA ++H C+ L+ + GK+ LH A G Q L ++
Sbjct: 247 GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGE 306
Query: 145 INLKDLDGNI---------------------------------PLLLAVQNGHSEICHFL 171
I+ D DGN PL LA N HS+ C L
Sbjct: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366
Query: 172 LDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 225
L G ++++ +K GRT L A G+ ++ L GAD + D G LHY+
Sbjct: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
Score = 85.9 bits (211), Expect = 2e-16
Identities = 66/243 (27%), Positives = 103/243 (42%), Gaps = 42/243 (17%)
Query: 50 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 109
D++G+T LA A GH++ + +++ +V D G +ALH H EC++ LL+ +
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
Query: 110 CPAESVDSSGKTALHYAAAQG---CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSE 166
DS G+T LHYAAA+G L + + + KD G PL A NG+
Sbjct: 702 VSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNEN 761
Query: 167 I----------------------CHFLLDHG------------ADVNSRNKSGRTALMLA 192
C + DHG + V+ R+ GRT L A
Sbjct: 762 CIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAA 821
Query: 193 CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS-----QDADL 247
++ L++ A +N VD+ G AL + + AG +L++ +D DL
Sbjct: 822 AFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDL 881
Query: 248 KTP 250
TP
Sbjct: 882 NTP 884
Score = 81.3 bits (199), Expect = 4e-15
Identities = 61/231 (26%), Positives = 99/231 (42%), Gaps = 39/231 (16%)
Query: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV---DV 79
L + + G E V LL ++ + K DS G+T H AAA+GH L ++ + D
Sbjct: 682 LHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
Query: 80 TAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESV------------------------ 115
+D G++ LH A N + CI LL+ KC + +
Sbjct: 741 CFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLG 800
Query: 116 ----------DSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHS 165
D G+T L AA ++ +Q+L H +P+N D G L++A +NG +
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQA 860
Query: 166 EICHFLLDHG-ADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 215
L++ AD+ ++K T L LAC G ++ K D +L++
Sbjct: 861 GAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLIN 911
Score = 80.1 bits (196), Expect = 9e-15
Identities = 70/279 (25%), Positives = 117/279 (41%), Gaps = 71/279 (25%)
Query: 43 GASATKHDSEGKTAFHLAAA----------------------------KGHVECLRVMIT 74
GA+ + D G+TA H AAA K CL ++
Sbjct: 436 GANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQ 495
Query: 75 HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPA--ESVDSSGKTALHYAAAQGCL 132
+ + + +D G++++H AA H +C+ LL+ ES + K+ LH AA G
Sbjct: 496 NDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHH 555
Query: 133 QAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD--------------- 177
QA+++L + ++++D G L LA GH+E L++ GA
Sbjct: 556 QALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHA 615
Query: 178 ----------------------VNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 215
V+ ++ G+T LMLA G +AV L++K A+++ VD
Sbjct: 616 SVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVD 675
Query: 216 SLGYNALHYSKLSENAGIQSLLL----SKISQDADLKTP 250
LG ALH ++ + +LL S + +D+ +TP
Sbjct: 676 ILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTP 714
Score = 76.6 bits (187), Expect = 1e-13
Identities = 49/162 (30%), Positives = 79/162 (48%)
Query: 78 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 137
DV D+ + LH+AA E I L+ S + D+ T LH A A +AVQ+
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 138 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 197
L +H + +N +D + PL +A N + ++ + VN ++ GRTAL A G
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 198 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 239
V L+ KGA++N D ALH++ + + +LL++
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Score = 73.2 bits (178), Expect = 1e-12
Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 10/169 (5%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD---VTAQ 82
A NG+ + LL +K K T H A H C +++ +D V+ +
Sbjct: 754 ACYNGNENCIEVLLEQK--CFRKFIGNPFTPLHCAIINDHGNCASLLLG-AIDSSIVSCR 810
Query: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH- 141
D G + L AA H EC++ LL+ P +VD+SGKTAL AA G AV IL
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD---VNSRNKSGRT 187
++ + +KD D N PL LA GH + +LD D +N +N + +T
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNALQT 919
Score = 66.2 bits (160), Expect = 1e-10
Identities = 41/127 (32%), Positives = 69/127 (54%)
Query: 114 SVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLD 173
++DS +T LH AA G + +++L + +N KD PL AV + E L+
Sbjct: 11 TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIK 70
Query: 174 HGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGI 233
H ADVN+R+K+ +T L +A + E +I + +N+ D G ALH++ L+ + +
Sbjct: 71 HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEM 130
Query: 234 QSLLLSK 240
+LLL+K
Sbjct: 131 VNLLLAK 137
Score = 44.3 bits (103), Expect = 6e-04
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 141 HKSP-INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 199
HK+ +N D + PL +A G +EI L+ GA VN+++ T L A S
Sbjct: 4 HKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEE 63
Query: 200 AVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 242
AV+ LIK AD+N D LH + ++ +++ +S
Sbjct: 64 AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLS 106
Score = 39.7 bits (91), Expect = 0.014
Identities = 20/57 (35%), Positives = 28/57 (49%)
Query: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMI 73
N L+ A ENG A V L+ A T D + T HLA +KGH +C +++
Sbjct: 845 NSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 115 bits (288), Expect = 2e-25
Identities = 64/202 (31%), Positives = 107/202 (52%), Gaps = 1/202 (0%)
Query: 23 LLQAVENGDAEKVASLLGK-KGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 81
++ A+ + + + LLG + + G +AA G+++ L+++I G +
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
QD G +A++ AA++ H + ++ L ++KCP + D SG+ ALH AA G Q+LC
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSF 467
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
S N++D + PL A +G+ + L + G +VN +N+ G T L+ A G + V
Sbjct: 468 GSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIV 527
Query: 202 EALIKKGADLNLVDSLGYNALH 223
E L + GADLN D G+ ALH
Sbjct: 528 ECLAEHGADLNACDKDGHIALH 549
Score = 105 bits (261), Expect = 3e-22
Identities = 65/223 (29%), Positives = 103/223 (46%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
++ L D N+ NK+ L ++ LL K+G+ D G A + A
Sbjct: 360 LQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWA 419
Query: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
A GHV+ L+ + + + +D +G ALH+AA+ H + + L D +
Sbjct: 420 ARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEE 479
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
T LH AA G + LCE +N+K+ +G PLL A G+ +I L +HGAD+N+
Sbjct: 480 TPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNA 539
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
+K G AL LA ++ L+ +G ++ D G LH
Sbjct: 540 CDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLH 582
Score = 96.7 bits (239), Expect = 1e-19
Identities = 58/184 (31%), Positives = 96/184 (52%), Gaps = 3/184 (1%)
Query: 50 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 109
D G+ A H+AA GH + +++ + G + QD + LH AA + ++ + L ++
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAG 501
Query: 110 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 169
C + G+T L A+A+G V+ L EH + +N D DG+I L LAV+ E+
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561
Query: 170 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 229
LL G V+ +++ G T L +AC+ G+ V AL + +L++ + G LH L+
Sbjct: 562 TLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLH---LAA 618
Query: 230 NAGI 233
N GI
Sbjct: 619 NNGI 622
Score = 93.6 bits (231), Expect = 8e-19
Identities = 58/182 (31%), Positives = 86/182 (47%)
Query: 11 SDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
S+ N +K ++ L VA L + G + + EG+T A+A+G+ + +
Sbjct: 469 SNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVE 528
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
+ HG D+ A D GH ALHLA + E I+ LL C + D G T LH A G
Sbjct: 529 CLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDG 588
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 190
+ V LCE +++ + G PL LA NG ++ +L GA V + G+TA
Sbjct: 589 NMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAED 648
Query: 191 LA 192
LA
Sbjct: 649 LA 650
Score = 80.1 bits (196), Expect = 9e-15
Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 1/212 (0%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
A G A+ VA LL G++ D E +T H AA G+ + + G +V ++
Sbjct: 452 AARYGHAD-VAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNRE 510
Query: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 145
G + L A+ +H+ + L + + D G ALH A + ++ ++ L +
Sbjct: 511 GETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFV 570
Query: 146 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 205
+ +D GN PL +A ++G+ I L + +++ NK GRT L LA G + V L
Sbjct: 571 DYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLC 630
Query: 206 KKGADLNLVDSLGYNALHYSKLSENAGIQSLL 237
GA + + + G A ++ ++ + LL
Sbjct: 631 LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 44.7 bits (104), Expect = 4e-04
Identities = 31/110 (28%), Positives = 54/110 (49%), Gaps = 4/110 (3%)
Query: 145 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEAL 204
+N + G PLL+A G+ +I L+ G+ ++ ++K G A+ A G + ++ L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431
Query: 205 IKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS----QDADLKTP 250
+ L++ D G ALH + +A + LL S S QD + +TP
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETP 481
Score = 42.0 bits (97), Expect = 0.003
Identities = 31/120 (25%), Positives = 53/120 (44%), Gaps = 2/120 (1%)
Query: 11 SDTNEWNKNDDRLLQ-AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
+D N +K+ L AV E + +LL + G D G T H+A G++ +
Sbjct: 535 ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIV 593
Query: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
+ ++ + G + LHLAA N + +R L E++ + GKTA A ++
Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSE 653
Score = 37.7 bits (86), Expect = 0.053
Identities = 17/49 (34%), Positives = 31/49 (63%)
Query: 177 DVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 225
DVN NK G L++A G+ ++ LIK+G+ +++ D G NA++++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWA 419
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 114 bits (284), Expect = 6e-25
Identities = 88/292 (30%), Positives = 128/292 (43%), Gaps = 47/292 (16%)
Query: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
L+ +V NG + V SLL K GA+ D G+TA H A GH EC+ ++ HG +
Sbjct: 657 LMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR 715
Query: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAES----VDSSGKTALHYAAAQGCLQAVQIL 138
D+ G + +HL+A H + LLQS ++ D+ G TALH+A G V++L
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 139 CEHK----------------------------------SPINLKDLDGNIPLLLAVQNGH 164
E + S +N D G PL A H
Sbjct: 776 LEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDH 835
Query: 165 SEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK-GADLNLVDSLGYNALH 223
E LL H A VNS + +G+T LM+A E G +N VE L+ A+L L D+ ALH
Sbjct: 836 VECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALH 895
Query: 224 YSKLSENAGIQSLLLSKISQ-------DADLKTPTKPKQHDQVSKISSERSG 268
+ + L+L KI+ +A L+TP + ++ + E G
Sbjct: 896 LACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLG 947
Score = 113 bits (283), Expect = 8e-25
Identities = 66/218 (30%), Positives = 104/218 (47%)
Query: 32 AEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALH 91
+E+ +L K A D +T H+AAA V+C ++ +V D G +ALH
Sbjct: 86 SEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALH 145
Query: 92 LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLD 151
AA + H E ++ LL + D + A+H+AA G ++ V++L H + + KD
Sbjct: 146 HAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205
Query: 152 GNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 211
PL A +G + +LLD G D+N N G T L +AC G V LI GA +
Sbjct: 206 SYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIV 265
Query: 212 NLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
N + G+ LH++ S + + LL D ++K+
Sbjct: 266 NQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKS 303
Score = 109 bits (273), Expect = 1e-23
Identities = 68/233 (29%), Positives = 116/233 (49%), Gaps = 4/233 (1%)
Query: 18 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 77
++ L+QA+ NGD ++V +L+ KK D+E +T H AA G E + ++I G
Sbjct: 7 RDQPSLVQAIFNGDPDEVRALIFKK-EDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
Query: 78 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 137
V A+D+ + LH A + E ++ LL+ + D + +T LH AAA ++ +
Sbjct: 66 RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
Query: 138 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 197
L S +N+ D G L A +GH E+ LL GA++N+ +K R A+ A +G
Sbjct: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
Query: 198 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP 250
V+ L+ GA++ D Y LH + ++G+ S++ + D+ P
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLH---AAASSGMISVVKYLLDLGVDMNEP 235
Score = 106 bits (264), Expect = 1e-22
Identities = 69/210 (32%), Positives = 100/210 (47%), Gaps = 1/210 (0%)
Query: 41 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100
+ GA D G T H+AA GH + +IT G D + G LHLAA + +
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
Query: 101 CIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAV 160
C RKLL S ++ D G+T LH AAA G L+ + +L + N KD G PL A
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Query: 161 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-AVEALIKKGADLNLVDSLGY 219
N + + L+ GA VN ++ G T L A + +E L++ A+ + D GY
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
Query: 220 NALHYSKLSENAGIQSLLLSKISQDADLKT 249
NA+HYS + L+ S+ D ++T
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMET 536
Score = 104 bits (260), Expect = 4e-22
Identities = 67/197 (34%), Positives = 109/197 (55%), Gaps = 5/197 (2%)
Query: 58 HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDS 117
HLAA GH + L V++ +D+ ++++G + L LAA H EC+ L+ D
Sbjct: 555 HLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDY 614
Query: 118 SGK-TALHYAAAQGCLQAVQILCEHKSP---INLKDLDGNIPLLLAVQNGHSEICHFLLD 173
K T +H AA G + +++L + P ++++D +G PL+L+V NGH++ + LL+
Sbjct: 615 ILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLN 674
Query: 174 HGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGI 233
GA+V++++K GRTAL G V+AL++ GA L DS G +H S + G+
Sbjct: 675 KGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGV 734
Query: 234 -QSLLLSKISQDADLKT 249
+LL S S DA+ T
Sbjct: 735 LGALLQSAASMDANPAT 751
Score = 102 bits (254), Expect = 2e-21
Identities = 67/218 (30%), Positives = 102/218 (46%), Gaps = 1/218 (0%)
Query: 11 SDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
+D N +KN L A K A L ++ D G+TA H AA GH E ++
Sbjct: 98 ADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVK 157
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
++++ G ++ A D A+H AA H E ++ L+ D T LH AA+ G
Sbjct: 158 LLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSG 217
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL- 189
+ V+ L + +N + GN PL +A NG + + L+D GA VN +N+ G T L
Sbjct: 218 MISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLH 277
Query: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227
A + +E L+ GAD+N+ G LH + L
Sbjct: 278 FAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTAL 315
Score = 99.0 bits (245), Expect = 2e-20
Identities = 65/220 (29%), Positives = 100/220 (45%), Gaps = 1/220 (0%)
Query: 12 DTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH-VECLR 70
D NE N + L + V + L GA + + +G T H AAA H CL
Sbjct: 231 DMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLE 290
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
+++ +G DV + G + LH+ A + + ++QS + D +G T LH AA G
Sbjct: 291 LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 190
+ L + + + G PL LA +G S+ C LL G D+++ + GRT L
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLH 410
Query: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSEN 230
A G+ + L+ GAD N D G + LHY+ + N
Sbjct: 411 AAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCN 450
Score = 96.7 bits (239), Expect = 1e-19
Identities = 66/244 (27%), Positives = 109/244 (44%), Gaps = 6/244 (2%)
Query: 9 RKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 68
R ++ N ++K D R + +V LL GA T D + T H AA+ G +
Sbjct: 162 RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISV 221
Query: 69 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA 128
++ ++ GVD+ + G++ LH+A N + +L+ + G T LH+AAA
Sbjct: 222 VKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAA 281
Query: 129 --QGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGR 186
G L +++L + + +N+K DG PL + +G ++ GA ++ +K+G
Sbjct: 282 STHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGN 340
Query: 187 TALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDAD 246
T L +A G + LI GAD G LH + LS G +S D
Sbjct: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALS---GFSDCCRKLLSSGFD 397
Query: 247 LKTP 250
+ TP
Sbjct: 398 IDTP 401
Score = 94.7 bits (234), Expect = 4e-19
Identities = 66/234 (28%), Positives = 105/234 (44%), Gaps = 8/234 (3%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD---VTAQ 82
A G E V L+ + + K +T H AA GH ECLR++I + V Q
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 649
Query: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHK 142
D G + L L+ N H +C+ LL ++ D G+TALH A G + V L +H
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 709
Query: 143 SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSR----NKSGRTALMLACEIGSS 198
+ L+D G P+ L+ GH + LL A +++ + G TAL AC G
Sbjct: 710 AKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHE 769
Query: 199 NAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTK 252
VE L+++ + ++ LH + +++N G +L+ + T +K
Sbjct: 770 TCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSK 822
Score = 89.4 bits (220), Expect = 2e-17
Identities = 59/195 (30%), Positives = 85/195 (43%)
Query: 38 LLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNS 97
LL GA +GKT H+ A G + +I G + +D G++ LH+AA+
Sbjct: 291 LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
Query: 98 HHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLL 157
H I L+ S G LH AA G + L I+ D G L
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLH 410
Query: 158 LAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL 217
A G+ E + LL+ GAD N ++K GR+ L A + + AL+ GA +N +D
Sbjct: 411 AAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470
Query: 218 GYNALHYSKLSENAG 232
G LHY+ S+ G
Sbjct: 471 GCTPLHYAATSDTDG 485
Score = 85.1 bits (209), Expect = 3e-16
Identities = 69/239 (28%), Positives = 123/239 (51%), Gaps = 14/239 (5%)
Query: 8 FRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVE 67
F+K++ N ++ ++ E G AE + LG +AT DS+G+T H AA HVE
Sbjct: 781 FQKTEGNAFSPLHCAVINDNE-GAAEMLIDTLGASIVNAT--DSKGRTPLHAAAFTDHVE 837
Query: 68 CLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESV-DSSGKTALHYA 126
CL+++++H V + D+TG + L +AA+N + L+ S ++ D+S TALH A
Sbjct: 838 CLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLA 897
Query: 127 AAQGCLQAVQILCE---HKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 183
++G + ++ E ++ IN + PL +A +NG + + LL GA V + ++
Sbjct: 898 CSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDE 957
Query: 184 SGRTALMLACEIGSSNA-----VEALIKKGADLNLVDSLGYNALH-YSKLSENAGIQSL 236
+G T LAC A + A + + + + SL +NA++ Y+ S+ ++L
Sbjct: 958 NGYTP-ALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEAL 1015
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 113 bits (282), Expect = 1e-24
Identities = 67/207 (32%), Positives = 98/207 (47%)
Query: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 93
KV LL K GAS G T H+AA GHV + ++ HG + G +ALH+A
Sbjct: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Query: 94 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 153
A++ E +R L+Q E+ +T LH +A G VQ L + + N G
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 154 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 213
PL L+ + GH ++ FLLDHGA ++ K G T L +A + G L++K A +
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Query: 214 VDSLGYNALHYSKLSENAGIQSLLLSK 240
G LH + +N + LLL +
Sbjct: 594 AGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Score = 108 bits (270), Expect = 2e-23
Identities = 66/218 (30%), Positives = 106/218 (48%), Gaps = 1/218 (0%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
A + G+A V LL + GA +G T H A GH + + +++ + ++
Sbjct: 275 ASKRGNANMVKLLLDR-GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333
Query: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 145
G S LH+A + H C++ LLQ P + V + TALH AA G + ++L + K+
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393
Query: 146 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 205
N K L+G PL +A + ++ LL HGA + + +SG T + +A +G N V L+
Sbjct: 394 NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 453
Query: 206 KKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 243
GA N + G ALH + S A + L+ +Q
Sbjct: 454 HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491
Score = 101 bits (252), Expect = 3e-21
Identities = 67/236 (28%), Positives = 117/236 (49%), Gaps = 9/236 (3%)
Query: 14 NEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMI 73
++ KN D + A E + ++ +K + K S+ ++ AA GH+E I
Sbjct: 6 SQLKKNRDLEINAEEEPEKKRKH----RKRSRDRKKKSDANASYLRAARAGHLEKALDYI 61
Query: 74 THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQ 133
+GVD+ + G +ALHLA+K H E + +LLQ + ++ G TALH A+ G +
Sbjct: 62 KNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAE 121
Query: 134 AVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 193
V++L + + +N + +G PL +A Q H E+ FLLD+GA + + G T L +A
Sbjct: 122 VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL 181
Query: 194 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
+ G V L++ + + ALH + ++ +LLL +AD+++
Sbjct: 182 QQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVES 232
Score = 100 bits (250), Expect = 5e-21
Identities = 86/373 (23%), Positives = 163/373 (43%), Gaps = 34/373 (9%)
Query: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 93
KVA +L K A+ G T H+A K ++ + +++ HG + A +G + +H+A
Sbjct: 381 KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVA 440
Query: 94 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 153
A H + +L+ + + G+TALH AA G + V+ L + + + K D
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ 500
Query: 154 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 213
PL ++ + G ++I LL GA N+ SG T L L+ G + L+ GA L++
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
Query: 214 VDSLGYNALHYSKLSENAGIQSLLLSK-ISQDADLKTPTKP------KQHDQVSKISSER 266
G+ LH + + +LLL K S DA K+ P + +V+ + ++
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 267 SGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRL 326
+P A +P ++ + I +T L + A+ +++
Sbjct: 621 GASP--HAAAKNGYTPLHIAAKKNQMDIATTLLE-----------YGADANAV------- 660
Query: 327 SDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE----AEADL 382
T + + ++++ D++SLL + A++ L NK L + ++ AE +
Sbjct: 661 ---TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717
Query: 383 SFDSYHSTQTDLG 395
+ ++ QT +G
Sbjct: 718 NQGAHVDAQTKMG 730
Score = 100 bits (249), Expect = 7e-21
Identities = 64/235 (27%), Positives = 110/235 (46%), Gaps = 3/235 (1%)
Query: 18 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 77
KN L GD LL + ++ TA H+AA GH + +V++
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 78 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 137
+ A+ G + LH+A K + + + LL+ ++V SG T +H AA G + V
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451
Query: 138 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 197
L H + N ++ G L +A ++G +E+ +L+ GA V ++ K +T L ++ +G
Sbjct: 452 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGK 511
Query: 198 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTK 252
++ V+ L+++GA N + GY LH LS G + + + A L TK
Sbjct: 512 ADIVQQLLQQGASPNAATTSGYTPLH---LSAREGHEDVAAFLLDHGASLSITTK 563
Score = 100 bits (248), Expect = 9e-21
Identities = 71/270 (26%), Positives = 123/270 (45%), Gaps = 7/270 (2%)
Query: 24 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 83
L + D +KVA LL +GAS G T H+AA K ++ ++ +G D A
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 84 TTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKS 143
G +++HLAA+ H + + LL + SG T LH AA + + ++L +
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
Query: 144 PINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEA 203
++ + G PL + G+ +I +FLL H A VN++ K+G T L A + G ++ +
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
Query: 204 LIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQH-----DQ 258
L++ A N + G AL ++ + L KI + + T T ++H +
Sbjct: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTL--KIVTEETMTTTTVTEKHKMNVPET 839
Query: 259 VSKISSERSGTPKKRKAPPPPISPTQLSDV 288
++++ +K AP +SDV
Sbjct: 840 MNEVLDMSDDEVRKANAPEMLSDGEYISDV 869
Score = 97.8 bits (242), Expect = 4e-20
Identities = 63/223 (28%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 89
G A+ V LL ++GAS + G T HL+A +GH + ++ HG ++ G +
Sbjct: 510 GKADIVQQLL-QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
Query: 90 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
LH+AAK E LLQ ++ SG T LH AA + +L + + +
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 150 LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
+G PL +A + +I LL++GAD N+ + G ++ LA + G + V L+ + A
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
Query: 210 DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTK 252
++NL + G LH + + + +L ++Q A + TK
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVL---VNQGAHVDAQTK 728
Score = 97.8 bits (242), Expect = 4e-20
Identities = 61/214 (28%), Positives = 102/214 (47%)
Query: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 93
+VA+LL +K AS G T H+AA + + +++ G A G++ LH+A
Sbjct: 579 EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
Query: 94 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 153
AK + + LL+ A +V G ++H AA +G + V +L + +NL + G
Sbjct: 639 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698
Query: 154 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 213
PL LA Q + L++ GA V+++ K G T L + C G+ V L++ A +N
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
Query: 214 VDSLGYNALHYSKLSENAGIQSLLLSKISQDADL 247
GY LH + + I ++LL + +L
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
Score = 94.4 bits (233), Expect = 5e-19
Identities = 68/255 (26%), Positives = 111/255 (43%), Gaps = 21/255 (8%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEK-----------------VASLLGKKG 43
+ +L RK DT K LLQ N D E VA+LL +
Sbjct: 203 LPALHIAARKDDT----KAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRA 258
Query: 44 ASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIR 103
A+ T H+A+ +G+ +++++ G + A+ G + LH A++ H + +
Sbjct: 259 AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVE 318
Query: 104 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 163
LL P S +G + LH A L VQ+L +H P++ D L +A G
Sbjct: 319 MLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCG 378
Query: 164 HSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
H ++ LLD A+ N++ +G T L +AC+ +E L+K GA + V G +H
Sbjct: 379 HYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438
Query: 224 YSKLSENAGIQSLLL 238
+ + I S L+
Sbjct: 439 VAAFMGHVNIVSQLM 453
Score = 93.2 bits (230), Expect = 1e-18
Identities = 63/206 (30%), Positives = 93/206 (45%)
Query: 33 EKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 92
E VA+ L GAS + +G T H+AA G +E +++ A +G + LH+
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 93 AAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDG 152
AA + + LL + +G T LH AA + + L E+ + N G
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664
Query: 153 NIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLN 212
+ LA Q GH ++ LL A+VN NKSG T L LA + N E L+ +GA ++
Sbjct: 665 IASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD 724
Query: 213 LVDSLGYNALHYSKLSENAGIQSLLL 238
+GY LH N I + LL
Sbjct: 725 AQTKMGYTPLHVGCHYGNIKIVNFLL 750
Score = 92.8 bits (229), Expect = 1e-18
Identities = 60/214 (28%), Positives = 99/214 (46%), Gaps = 1/214 (0%)
Query: 33 EKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 92
E+V +L + A G + H+A H+ C+++++ H V V +ALH+
Sbjct: 314 EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHV 373
Query: 93 AAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDG 152
AA H++ + LL K + +G T LH A + ++ +++L +H + I G
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 153 NIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLN 212
P+ +A GH I L+ HGA N+ N G TAL +A G + V L++ GA +
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493
Query: 213 LVDSLGYNALHYS-KLSENAGIQSLLLSKISQDA 245
LH S +L + +Q LL S +A
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Score = 92.8 bits (229), Expect = 1e-18
Identities = 59/223 (26%), Positives = 102/223 (45%), Gaps = 1/223 (0%)
Query: 18 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 77
+ + L A +G AE V L+ + GA + +T H++A G + ++ ++ G
Sbjct: 465 RGETALHMAARSGQAEVVRYLV-QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA 523
Query: 78 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 137
A T+G++ LHL+A+ H + LL G T LH AA G L+ +
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583
Query: 138 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 197
L + + + G PL +A + ++ LLD GA ++ K+G T L +A +
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643
Query: 198 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
+ L++ GAD N V G ++H + + + SLLL +
Sbjct: 644 MDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Score = 90.9 bits (224), Expect = 5e-18
Identities = 72/265 (27%), Positives = 126/265 (47%), Gaps = 15/265 (5%)
Query: 12 DTNEWNKNDDRLLQ-AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
D N N+N L A + G E V+ LL ++ A+ +G TA H+A+ G E ++
Sbjct: 66 DINICNQNGLNALHLASKEGHVEVVSELLQRE-ANVDAATKKGNTALHIASLAGQAEVVK 124
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
V++T+G +V AQ G + L++AA+ +H E ++ LL + G T L A QG
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQG 184
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLL-LAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
Q V +L E+ + ++ +P L +A + ++ LL + + + +KSG T L
Sbjct: 185 HDQVVSLLLENDTKGKVR-----LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPL 239
Query: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ-DADLK 248
+A G+ N L+ + A ++ LH + NA + LLL + ++ DA +
Sbjct: 240 HIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTR 299
Query: 249 TPTKP------KQHDQVSKISSERS 267
P H+QV ++ +R+
Sbjct: 300 DGLTPLHCGARSGHEQVVEMLLDRA 324
Score = 79.0 bits (193), Expect = 2e-14
Identities = 54/235 (22%), Positives = 109/235 (46%), Gaps = 10/235 (4%)
Query: 9 RKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 68
R+++ + K + L +V +L GA+ G T ++AA + H+E
Sbjct: 96 REANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEV 155
Query: 69 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKT---ALHY 125
++ ++ +G + G + L +A + H + + LL++ D+ GK ALH
Sbjct: 156 VKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN-------DTKGKVRLPALHI 208
Query: 126 AAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSG 185
AA + +A +L ++ + +++ G PL +A G+ + LL+ A V+ ++
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 186 RTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
T L +A + G++N V+ L+ +GA ++ G LH S + + +LL +
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323
Score = 77.8 bits (190), Expect = 5e-14
Identities = 55/221 (24%), Positives = 104/221 (47%), Gaps = 11/221 (4%)
Query: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKT---AFHLAAAKGHVECLRVMITHGVDV 79
L A++ G + V+ LL ++D++GK A H+AA K + +++ + +
Sbjct: 177 LAVALQQGHDQVVSLLL--------ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228
Query: 80 TAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILC 139
+ +G + LH+AA + LL + + T LH A+ +G V++L
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL 288
Query: 140 EHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 199
+ + I+ K DG PL ++GH ++ LLD A + S+ K+G + L +A + N
Sbjct: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Query: 200 AVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
V+ L++ ++ V + ALH + + + +LL K
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Score = 59.3 bits (142), Expect = 2e-08
Identities = 36/130 (27%), Positives = 56/130 (43%)
Query: 9 RKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 68
R ++ N NK+ L D VA +L +GA G T H+ G+++
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI 745
Query: 69 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA 128
+ ++ H V A+ G++ LH AA+ H I LLQ+ + +G TAL A
Sbjct: 746 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805
Query: 129 QGCLQAVQIL 138
G + V L
Sbjct: 806 LGYISVVDTL 815
Score = 49.3 bits (116), Expect = 2e-05
Identities = 119/580 (20%), Positives = 232/580 (40%), Gaps = 90/580 (15%)
Query: 310 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 369
PP S+ + +++DS G D++L+ + Q D Q K + L+ E + +
Sbjct: 2082 PPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHD-----QDK-SPLSDSGFETRSE 2135
Query: 370 LQAKSPKEAEADLSFDSYHS---------TQTDL-------GPSLGKPGETSPPDSKS-S 412
+P+ AE+ +H T+T++ PS G +T P + S
Sbjct: 2136 KTPSAPQSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPK 2195
Query: 413 PSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNT 472
PS L T + ++ E ++ Q + S E + ++ + + E T
Sbjct: 2196 PSPTFMELEPKPTTSSIK-----EKVKAFQMKASSEEDDHNRVLSKGMRVKEETHITTTT 2250
Query: 473 EISENS----SDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVT 528
+ +S S++++ET S ++ MK S + K EL
Sbjct: 2251 RMVYHSPPGGEGASERIEETMSVHD-IMKAFQSGRDPSK----------------ELAGL 2293
Query: 529 EEEINVLKQDL-QNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVI 587
E + + D+ ++A E S ++ EK +++ KL ER +I+ +E+ + + + +
Sbjct: 2294 FEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKL-ER----IIEVHIEKGNQAEPTEVIIR 2348
Query: 588 ENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSE 647
E + ++ ++ + LKD L + E + +E +E E
Sbjct: 2349 ETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLE 2408
Query: 648 LSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYS 707
S++ E ED R +A+ I ++ L L+ S +D LSE++ +
Sbjct: 2409 SSRVNTPVSQE-EDSRPS------SAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESY 2461
Query: 708 KVLNELTQLKQLVDAQKENSVSITEHL-QVITTLRTAAKEMEEKISNL-KEHLASK---- 761
+ ++ ++L + + S+T+H + L+ + K EKI+ K+ + SK
Sbjct: 2462 RFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYKD 2521
Query: 762 --EVEVAKLEKQLLEEKAAM----------TDAMVPRSSYEKLQSSLESEVSVLASKLKE 809
E V K+ K +K + AM R + ++L E + ++
Sbjct: 2522 VSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREK--LIYEDRVDR 2579
Query: 810 SVKEKEKVHSEVVQIRSEVSQVKREK-ENIQTLLKSKEQE 848
+VKE E + +EVSQ R+K E + L+S E++
Sbjct: 2580 TVKEAE-------EKLTEVSQFFRDKTEKLNDELQSPEKK 2612
Score = 42.4 bits (98), Expect = 0.002
Identities = 143/761 (18%), Positives = 275/761 (36%), Gaps = 134/761 (17%)
Query: 244 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAP--------------------PPPISPT 283
D L++P QHDQ S+ + K P PP I+ T
Sbjct: 2106 DTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPPVITET 2165
Query: 284 QLSDV-----------SSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTG 332
+ V P++ P+S K S F E K SSI+E
Sbjct: 2166 RTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQ----- 2220
Query: 333 ADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQT 392
+ SSE D HN+ L ++ K YHS
Sbjct: 2221 ----MKASSEEDD----------------HNRVLSKGMRVKEETHITTTTRM-VYHSPPG 2259
Query: 393 DLGPSLGKPGETSPPDSKSSPSVLIHSLGK---STTDNDVRIQQLQEILQDLQKRLESSE 449
G S + ++ +H + K S D + L E + + S
Sbjct: 2260 GEGAS-----------ERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKSAVSPDVHKSA 2308
Query: 450 AERKQLQVELQSR---RAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQM 506
AE E ++ + E + + E + ++ET+ E KE+ QK +
Sbjct: 2309 AETSAQHAEKDNQMKPKLERIIEVHIEKGNQAEPTEVIIRETKKHPE---KEMYVYQKDL 2365
Query: 507 KLGLVS-----PESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN-----KEKVREL 556
G ++ PE D + E EEE ++ L + LE S N +E R
Sbjct: 2366 SRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLESSRVNTPVSQEEDSRPS 2425
Query: 557 EEKLVEREKGTVIKPPVE---EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD 613
+L+ + +K + EY + + S EK L EK + + ++
Sbjct: 2426 SAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESYRFAEKMLLSEKLDVSHSD---TEE 2482
Query: 614 TLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKE-AQAELEDYRKRKSLEDVT 672
++ +S+ K + ++ K++ LS++YK+ ++ + K + + VT
Sbjct: 2483 SVTDHAGPPSSELQGSDKRSREKIATAPKKEI--LSKIYKDVSENGVGKVSKDEHFDKVT 2540
Query: 673 AEY----IHKAEHEKLMQLTNVSRAKAEDAL---SEMKSQYSKVLNELTQLKQLVDAQKE 725
+ + +H M+ T + + L + + +LT++ Q ++
Sbjct: 2541 VLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQFF---RD 2597
Query: 726 NSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP 785
+ + + LQ + E + + N KE+ +S+ + EK LL E A D V
Sbjct: 2598 KTEKLNDELQ--------SPEKKARPKNGKEY-SSQSPTSSSPEKVLLTELLASNDEWVK 2648
Query: 786 RSSY----EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTL 841
+ + + E S+ +S K + ++ + V+ + +SQ K + Q+
Sbjct: 2649 ARQHGPDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSK-APDGPQSG 2707
Query: 842 LKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSL 901
+ K+ +++ + KF+Q +A+S +ED+ K + V K++E+ +
Sbjct: 2708 FQLKQSKLSSIRLKFEQG--------THAKSKDMSQEDR-KSDGQSRIPVKKIQESKLPV 2758
Query: 902 SQLSYSTSSSKRQSQQLEALQQQVK-QLQNQLAECKKQHQE 941
Y + ++Q + ++ + V Q + + K +H +
Sbjct: 2759 ----YQVFAREKQQKAIDLPDESVSVQKDFMVLKTKDEHAQ 2795
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 113 bits (282), Expect = 1e-24
Identities = 67/214 (31%), Positives = 110/214 (51%), Gaps = 1/214 (0%)
Query: 25 QAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDT 84
+A E+G + + L+G G D EG TA HLAA +GH+ L+ ++ G+D+ Q+
Sbjct: 165 RAAEHGQLDALDFLVGS-GCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNA 223
Query: 85 TGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 144
G +ALH AA SH +C++ LL++ ++ + LHYAA G ++L
Sbjct: 224 EGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGC 283
Query: 145 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEAL 204
N+ D G PL LAV++ + L++ +DVN+ + +T L LA E + + L
Sbjct: 284 ANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADML 343
Query: 205 IKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
+ G DLNL D G AL + S + + +++
Sbjct: 344 LIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
Score = 95.1 bits (235), Expect = 3e-19
Identities = 56/188 (29%), Positives = 92/188 (48%), Gaps = 2/188 (1%)
Query: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ--SKC 110
G A L+A GH+ L++++ G + + G + LH AA+ H + +++
Sbjct: 91 GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV 150
Query: 111 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHF 170
+ VD G+TA H AA G L A+ L N+KD +GN L LA GH +
Sbjct: 151 ALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQR 210
Query: 171 LLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSEN 230
L+D G D+ +N G TAL A + V+ L++ G+ +N + + LHY+ LS +
Sbjct: 211 LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 270
Query: 231 AGIQSLLL 238
+ +L+
Sbjct: 271 EDVSRVLI 278
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/224 (28%), Positives = 98/224 (43%), Gaps = 5/224 (2%)
Query: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ--DTTGHSALH 91
++ +L GA +G T H AA KGHV L ++ DV D G +A H
Sbjct: 105 RILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 164
Query: 92 LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLD 151
AA++ + + L+ S C D G TALH AA +G + +Q L + + ++ +
Sbjct: 165 RAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE 224
Query: 152 GNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 211
G L A H + LL G+ VN+ + + L A GS + LI G
Sbjct: 225 GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284
Query: 212 NLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQ 255
N+VD G + LH L+ +L+ I+ D+D+ +Q
Sbjct: 285 NVVDHQGASPLH---LAVRHNFPALVRLLINSDSDVNAVDNRQQ 325
Score = 62.0 bits (149), Expect = 3e-09
Identities = 43/146 (29%), Positives = 75/146 (51%), Gaps = 12/146 (8%)
Query: 90 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
LH AA+ ++ +++L+ + + + G+ ALH+AA G QAV++L EH++ ++ +D
Sbjct: 19 LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
Query: 150 LDGNI----------PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 199
G + LLL+ GH I L++ GA ++ +K G T L A + G
Sbjct: 79 AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
Query: 200 AVEALIKKGADLNL--VDSLGYNALH 223
+ +++ D+ L VD LG A H
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFH 164
Score = 33.9 bits (76), Expect = 0.77
Identities = 15/59 (25%), Positives = 33/59 (55%)
Query: 50 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQS 108
D+ +T HLAA + +++ GVD+ +D G +AL +A +++H + ++++
Sbjct: 321 DNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 112 bits (280), Expect = 2e-24
Identities = 147/675 (21%), Positives = 297/675 (44%), Gaps = 133/675 (19%)
Query: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
L K+ Q K Q K+ + D+ +H D + K GE + K + + +L
Sbjct: 777 LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESK-GEMKKENMKKDEA--LKAL 833
Query: 421 GKSTTDNDVRIQQLQEILQ----DLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISE 476
++ ++++QL L+ +L L E +++ + +L+ + E+ CL +
Sbjct: 834 QNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
Query: 477 NSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLK 536
N S L+ET S+ ++ L Q+QM + E++ N E++++ L+
Sbjct: 894 NHS-----LQET-SEQNVILQHTLQQQQQM----LQQETIRNGELEDTQTKLEKQVSKLE 943
Query: 537 QDLQNALEESERNKEKVRELEEKL--------VEREK-----GTV--IKPPVEEYEEM-- 579
Q+LQ ++ E + EK+R++EEK ++R+K GT +K +++Y+E
Sbjct: 944 QELQ---KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 1000
Query: 580 ---------------KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 624
K+ + S ++ + + EK A +E+ KL+ + ++++T EA
Sbjct: 1001 KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT-EAL 1059
Query: 625 DEAEDMKEAMNRMIDELN---KQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 681
+ E ++ + EL +Q+ EL + ++AQ LE+ K +++D+TAE
Sbjct: 1060 QKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE--KYTTIKDLTAE------- 1110
Query: 682 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ----KENSVSITEHLQVI 737
L E K + EL ++ Q + + K+ + +T HL +
Sbjct: 1111 -----------------LRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVT-HLDM- 1151
Query: 738 TTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLE 797
T+R EME+KI L+ L E+E+ + KQ+ S +KLQ++
Sbjct: 1152 -TIREHRGEMEQKIIKLEGTLEKSELELKECNKQI-------------ESLNDKLQNA-- 1195
Query: 798 SEVSVLASKLKESVKEKEKV----HSEVVQIRSEVSQVKREKENIQTLLKSKEQEV-NEL 852
KE ++EKE + E+ Q++ E+ + ++ + +++++K +EQ + +
Sbjct: 1196 ----------KEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQY 1245
Query: 853 LQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS------- 905
+ QE ++ S ++L E + +++ + +E+ +L L + QLS
Sbjct: 1246 KEAIDLGQELRLTREQVQNSHTELAEARHQQV-QAQREIERLSSELEDMKQLSKEKDAHG 1304
Query: 906 ----YSTSSSKRQSQQLEA-LQQQVKQLQNQLAECKK-QHQEVISVYRMHLLYAVQGQMD 959
+SK + LEA +Q ++K+L ++ K+ H E+IS H + +
Sbjct: 1305 NHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQ 1364
Query: 960 EDVQKVLKQILTMCK 974
+ + L + L K
Sbjct: 1365 KSSVQQLNEQLEKAK 1379
Score = 77.4 bits (189), Expect = 6e-14
Identities = 129/585 (22%), Positives = 263/585 (44%), Gaps = 72/585 (12%)
Query: 416 LIHSLGKSTTDNDVRIQQLQEILQDLQK-RLESSEAERKQLQVELQSRRAELVCLNNTEI 474
L L K N + Q ++ + E +++ K +E ++A V + +I
Sbjct: 234 LREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQI 293
Query: 475 SENSSDLSQK---LKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEE 531
+++S + L+E ++K E++ K V+ ++ L+ ++EE
Sbjct: 294 INLEAEVSAQDKVLREAENKLEQSQKMVIEKEQS-------------------LQESKEE 334
Query: 532 INVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI----KPPVEEYEEMKSSYCSVI 587
LK DL LE++++ K R+ E L E+ + K V E E + ++
Sbjct: 335 CIKLKVDL---LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEIL 391
Query: 588 E----NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 643
E N KE L E+ + E+ LK+ L+ Q+ +E ++ E ++ M E+
Sbjct: 392 ERNLTNCEKENKRLQERCGLYKSELEILKEKLR-QLKEENNNGKEKLR-IMAVKNSEVMA 449
Query: 644 QVSELSQLYKEAQAELED----YRKRKSLEDVTAEYIHK--AEHEKLMQLTNVSRAKAED 697
Q++E Q + ++ELE+ R + SL + E + A++E+L ++ + + E
Sbjct: 450 QLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERL----DLCQQEIES 505
Query: 698 ALSEMKSQYSKVLNELTQLKQLVDAQKENS-VSITEHLQVITTLRTAAKEMEEKISNLKE 756
+ E++S K++++L ++L + S ++ + + IS L+
Sbjct: 506 SRVELRS-LEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRI 564
Query: 757 HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESE-VSVLASKLKESVKEKE 815
LA KE E+ KL L + + + S SSLE+E V + ++ ESVK++
Sbjct: 565 KLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQN 624
Query: 816 KVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL-------LQKFQQAQEELAEMKR 868
+ H+ Q E ++ E ++T L E E ++L +FQ QEEL E
Sbjct: 625 Q-HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK-- 681
Query: 869 YAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQL 928
A +SSKLE + KK +++ +L+E + ++YS+ ++K + E +++ K +
Sbjct: 682 -ASNSSKLESEMTKKCSQLLTLEKQLEEKI-----VAYSSIAAKNAELEQELMEKNEK-I 734
Query: 929 QNQLAECKKQHQEVISVY----RMHLLYAVQGQMDEDVQKVLKQI 969
++ +H+++ + ++HL +M++ ++++ Q+
Sbjct: 735 RSLETNINTEHEKICLAFEKAKKIHL--EQHKEMEKQIERLEAQL 777
Score = 54.3 bits (129), Expect = 5e-07
Identities = 109/500 (21%), Positives = 198/500 (39%), Gaps = 100/500 (20%)
Query: 523 HELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLV----EREKGTVIKPPVEEYEE 578
HEL++TE + L ++L + + EKL+ G + P YE
Sbjct: 145 HELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSP---YEN 201
Query: 579 MKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL----------------------- 615
+ S + K + +F +EI L++ L
Sbjct: 202 VCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFES 261
Query: 616 ----------KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED---- 661
K M + A +A + + I L +VS ++ +EA+ +LE
Sbjct: 262 IHFELTQSRAKVSMLESAQQQAASV-PILEEQIINLEAEVSAQDKVLREAENKLEQSQKM 320
Query: 662 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAE--------DALSEMKSQYSKVLNE 712
K +SL++ E I K + + L Q RA+ + + LS+ QY K + E
Sbjct: 321 VIEKEQSLQESKEECI-KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAE 379
Query: 713 LTQLKQ---------LVDAQKENSVSITE----HLQVITTLRTAAKEMEEKISNLKEHLA 759
+ Q L + +KEN + E + + L+ ++++E+ +N KE L
Sbjct: 380 KLEKVQAEEEILERNLTNCEKENK-RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLR 438
Query: 760 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 819
V+ +++ QL E R S KL+S LE++ +L K + E ++
Sbjct: 439 IMAVKNSEVMAQLTES----------RQSILKLESELENKDEILRDKF-SLMNENRELKV 487
Query: 820 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 879
V + ++E E+ + L+S E+ +++L K ++ + + +Y SS +ED
Sbjct: 488 RVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK-RELFGFKSYLSKYQMSSFSNKED 546
Query: 880 KDKKINEMSK---------------EVTKLKEAL--NSLSQLSYSTSSSKRQSQQLEALQ 922
+ E +K E+ KL L N LSQ S T + ++S +L +L+
Sbjct: 547 RCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQ-SLITCNDSQESSKLSSLE 605
Query: 923 -QQVKQLQNQLAECKKQHQE 941
+ VK +Q+AE K +
Sbjct: 606 TEPVKLGGHQVAESVKDQNQ 625
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.122 0.314
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,605,024
Number of Sequences: 37866
Number of extensions: 1488172
Number of successful extensions: 29525
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 862
Number of HSP's successfully gapped in prelim test: 1624
Number of HSP's that attempted gapping in prelim test: 9935
Number of HSP's gapped (non-prelim): 10009
length of query: 980
length of database: 18,247,518
effective HSP length: 112
effective length of query: 868
effective length of database: 14,006,526
effective search space: 12157664568
effective search space used: 12157664568
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.