Guide to the Human Genome
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Search of human proteins with 224809432

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224809432 transmembrane and tetratricopeptide repeat
containing 3 [Homo sapiens]
         (914 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224809432 transmembrane and tetratricopeptide repeat containi...  1813   0.0  
gi|118766328 transmembrane and tetratricopeptide repeat containi...   392   e-108
gi|118766330 transmembrane and tetratricopeptide repeat containi...   392   e-108
gi|22749211 transmembrane and tetratricopeptide repeat containin...   325   9e-89
gi|83415184 transmembrane and tetratricopeptide repeat containin...   215   2e-55
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]      108   3e-23
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]      108   3e-23
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]                     73   1e-12
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    59   3e-08
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    59   3e-08
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom...    59   3e-08
gi|54607135 translocase of outer mitochondrial membrane 70 homol...    57   8e-08
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi...    55   2e-07
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi...    55   2e-07
gi|7661950 SH2 domain binding protein 1 [Homo sapiens]                 52   3e-06
gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sap...    51   4e-06
gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo sap...    51   4e-06
gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sap...    51   4e-06
gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ...    50   7e-06
gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens]         50   1e-05
gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo sap...    49   3e-05
gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo sap...    49   3e-05
gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo sap...    49   3e-05
gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo sap...    49   3e-05
gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo sapi...    49   3e-05
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ...    47   6e-05
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa...    47   8e-05
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa...    47   8e-05
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa...    47   8e-05
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ...    47   8e-05

>gi|224809432 transmembrane and tetratricopeptide repeat containing
           3 [Homo sapiens]
          Length = 914

 Score = 1813 bits (4697), Expect = 0.0
 Identities = 914/914 (100%), Positives = 914/914 (100%)

Query: 1   MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP 60
           MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP
Sbjct: 1   MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP 60

Query: 61  MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS 120
           MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS
Sbjct: 61  MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS 120

Query: 121 VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL 180
           VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL
Sbjct: 121 VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL 180

Query: 181 VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI 240
           VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI
Sbjct: 181 VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI 240

Query: 241 VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL 300
           VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL
Sbjct: 241 VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL 300

Query: 301 CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI 360
           CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI
Sbjct: 301 CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI 360

Query: 361 PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK 420
           PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK
Sbjct: 361 PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK 420

Query: 421 TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI 480
           TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI
Sbjct: 421 TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI 480

Query: 481 GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA 540
           GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA
Sbjct: 481 GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA 540

Query: 541 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW 600
           NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW
Sbjct: 541 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW 600

Query: 601 YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY 660
           YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY
Sbjct: 601 YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY 660

Query: 661 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK 720
           INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK
Sbjct: 661 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK 720

Query: 721 ALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVV 780
           ALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVV
Sbjct: 721 ALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVV 780

Query: 781 YFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKK 840
           YFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKK
Sbjct: 781 YFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKK 840

Query: 841 IPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAA 900
           IPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAA
Sbjct: 841 IPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAA 900

Query: 901 LKRLEEIERILNGE 914
           LKRLEEIERILNGE
Sbjct: 901 LKRLEEIERILNGE 914


>gi|118766328 transmembrane and tetratricopeptide repeat containing
           4 isoform 2 [Homo sapiens]
          Length = 741

 Score =  392 bits (1006), Expect = e-108
 Identities = 248/694 (35%), Positives = 383/694 (55%), Gaps = 49/694 (7%)

Query: 11  LIVG-VVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKS 69
           L+VG V   C+  S    FVFDD  AI++NKDL   TPL  L+ +DFWG+ +S   SHKS
Sbjct: 24  LVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKS 83

Query: 70  YRPLTVLTFRLNYLLSE-LKPMSYHLLNMIFHAVVSVIFLKVC--------------KLF 114
           YRPLTVLTFR+NY LS    P+ +H++N++ H+ +SV+ + V               +L 
Sbjct: 84  YRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLH 143

Query: 115 LDNKSSVIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRS------KGPDNS 168
           L  ++S++A+LLFAVHP+HTE V GVVGRA+LL ++FFL +FL Y ++      +G  +S
Sbjct: 144 LAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSS 203

Query: 169 IIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSI 228
             W  + L++FL AVA LCKEQGITV+G+  V+++ +   + +  L        + K   
Sbjct: 204 TFW--VLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNV--LEIVQKVLHKDKSLE 259

Query: 229 PFSMLQT---LVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTP-TRQLTFN 284
              ML+    L ++ +L      ++ +R +++ +  P FT  DNPA+ + +   R + +N
Sbjct: 260 NLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYN 319

Query: 285 YLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFT-FFCFLGMLGVFSIRYSGD 343
           Y   +NAWLLL P  LC DW+MG IPLI+S+ D R +A    +FC +G++        G 
Sbjct: 320 YYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGH 379

Query: 344 SSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFK 403
             + + + L  + +PF+PASNLFF VGFVVAERVLY+PS+G+C+L+  G+  +S  +  K
Sbjct: 380 KRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKK 439

Query: 404 KLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFE 463
           KL    +  ++  ++L+   R+ +W SE  LF SAL V   NAK+  N+G  L ++ N  
Sbjct: 440 KLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQT 499

Query: 464 RALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARI 523
            A++Y+ +A  + P  + A  N+G   K  N  +EAEE   +              A +I
Sbjct: 500 AAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSL--------------AVQI 545

Query: 524 APNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAK 583
            P+    ++NL  +++ +  R E A+Q YR AI  R  +   Y + G L   +N+ + A 
Sbjct: 546 QPDFAAAWMNL-GIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDAL 604

Query: 584 EAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQE 643
            A+  A  L   ++  W N+ I+        +A      ALEL P     +F+ A V+ +
Sbjct: 605 NAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGK 664

Query: 644 SGEVKLRPEARKRLLSYINEEPLDANGYFNLGML 677
           S + K   E+    L  I   P  A+ + NL +L
Sbjct: 665 SQKYK---ESEALFLKAIKANPNAASYHGNLAVL 695



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 52/241 (21%), Positives = 107/241 (44%), Gaps = 10/241 (4%)

Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
           +I+    +L+  +    ++ +  AL +   NA + YN+     +      A++ +  A+ 
Sbjct: 451 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 510

Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
           LNPK+  A+ N   +++E  E++   EA + L   +  +P  A  + NLG++    K+  
Sbjct: 511 LNPKYVHAMNNLGNILKERNELQ---EAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFE 567

Query: 686 EAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHI---KGLILK 742
            AE   + AIK +  +    +NL  LY+   + + AL          P+H      +I  
Sbjct: 568 AAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMI-- 625

Query: 743 GDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP 802
             IL++   ++  A+      LE+ P++     +L  V  + +   ++E   L+ +   P
Sbjct: 626 --ILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANP 683

Query: 803 H 803
           +
Sbjct: 684 N 684


>gi|118766330 transmembrane and tetratricopeptide repeat containing
           4 isoform 1 [Homo sapiens]
          Length = 760

 Score =  392 bits (1006), Expect = e-108
 Identities = 248/694 (35%), Positives = 383/694 (55%), Gaps = 49/694 (7%)

Query: 11  LIVG-VVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKS 69
           L+VG V   C+  S    FVFDD  AI++NKDL   TPL  L+ +DFWG+ +S   SHKS
Sbjct: 43  LVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKS 102

Query: 70  YRPLTVLTFRLNYLLSE-LKPMSYHLLNMIFHAVVSVIFLKVC--------------KLF 114
           YRPLTVLTFR+NY LS    P+ +H++N++ H+ +SV+ + V               +L 
Sbjct: 103 YRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLH 162

Query: 115 LDNKSSVIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRS------KGPDNS 168
           L  ++S++A+LLFAVHP+HTE V GVVGRA+LL ++FFL +FL Y ++      +G  +S
Sbjct: 163 LAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSS 222

Query: 169 IIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSI 228
             W  + L++FL AVA LCKEQGITV+G+  V+++ +   + +  L        + K   
Sbjct: 223 TFW--VLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNV--LEIVQKVLHKDKSLE 278

Query: 229 PFSMLQT---LVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTP-TRQLTFN 284
              ML+    L ++ +L      ++ +R +++ +  P FT  DNPA+ + +   R + +N
Sbjct: 279 NLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYN 338

Query: 285 YLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFT-FFCFLGMLGVFSIRYSGD 343
           Y   +NAWLLL P  LC DW+MG IPLI+S+ D R +A    +FC +G++        G 
Sbjct: 339 YYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGH 398

Query: 344 SSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFK 403
             + + + L  + +PF+PASNLFF VGFVVAERVLY+PS+G+C+L+  G+  +S  +  K
Sbjct: 399 KRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKK 458

Query: 404 KLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFE 463
           KL    +  ++  ++L+   R+ +W SE  LF SAL V   NAK+  N+G  L ++ N  
Sbjct: 459 KLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQT 518

Query: 464 RALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARI 523
            A++Y+ +A  + P  + A  N+G   K  N  +EAEE   +              A +I
Sbjct: 519 AAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSL--------------AVQI 564

Query: 524 APNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAK 583
            P+    ++NL  +++ +  R E A+Q YR AI  R  +   Y + G L   +N+ + A 
Sbjct: 565 QPDFAAAWMNL-GIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDAL 623

Query: 584 EAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQE 643
            A+  A  L   ++  W N+ I+        +A      ALEL P     +F+ A V+ +
Sbjct: 624 NAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGK 683

Query: 644 SGEVKLRPEARKRLLSYINEEPLDANGYFNLGML 677
           S + K   E+    L  I   P  A+ + NL +L
Sbjct: 684 SQKYK---ESEALFLKAIKANPNAASYHGNLAVL 714



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 52/241 (21%), Positives = 107/241 (44%), Gaps = 10/241 (4%)

Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
           +I+    +L+  +    ++ +  AL +   NA + YN+     +      A++ +  A+ 
Sbjct: 470 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 529

Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
           LNPK+  A+ N   +++E  E++   EA + L   +  +P  A  + NLG++    K+  
Sbjct: 530 LNPKYVHAMNNLGNILKERNELQ---EAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFE 586

Query: 686 EAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHI---KGLILK 742
            AE   + AIK +  +    +NL  LY+   + + AL          P+H      +I  
Sbjct: 587 AAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMI-- 644

Query: 743 GDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP 802
             IL++   ++  A+      LE+ P++     +L  V  + +   ++E   L+ +   P
Sbjct: 645 --ILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANP 702

Query: 803 H 803
           +
Sbjct: 703 N 703


>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
           [Homo sapiens]
          Length = 836

 Score =  325 bits (834), Expect = 9e-89
 Identities = 246/822 (29%), Positives = 390/822 (47%), Gaps = 124/822 (15%)

Query: 18  ACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLT 77
           A Y N+L   F +DD  AI  N+DL P TP   +F NDFWGT ++   SHKSYRPL  L+
Sbjct: 13  ALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLS 72

Query: 78  FRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFL-DNKSSVIASLLFAVHPIHTEA 136
           FRLN+ +  L P SYHL+N++ HA V+ +F    K+ L D   + +A L+FA HPIHTEA
Sbjct: 73  FRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEA 132

Query: 137 VTGVVGRAELLSSIFFLAAFLSYTR--SKGPDNSIIWTPIALTVFLVAVATLCKEQGITV 194
           V G+VGRA++ +S+FFL + L Y +  S    ++  W     +      + L KEQG+TV
Sbjct: 133 VAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTV 192

Query: 195 VGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRV 254
           + +  VY+VF+     +  +  T     + K       L   + + +L+F    L+  R+
Sbjct: 193 LAVSAVYDVFVFHRLKIKQILPT---IYKRKN------LSLFLSISLLIFWGSSLLGARL 243

Query: 255 QVIQSQLPVFTRFDNPAAVSPTP-TRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIE 313
             + ++ P F+  DNPAA S +  TR LTF YL   N WLLL P  L  DW+M  +PL++
Sbjct: 244 YWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLK 303

Query: 314 SLLDIRNLATFTFFCFLGMLGVFSIR------------------------------YSGD 343
           ++ D RNL T  F+  L +L  + ++                              Y   
Sbjct: 304 TVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNS 363

Query: 344 SSKT--------------------------VLMALCLMALPFIPASNLFFPVGFVVAERV 377
            +K+                          V+++L L+ +PF+PA+NLFF VGFV+AERV
Sbjct: 364 ETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERV 423

Query: 378 LYVPSMGFCILVAHGWQKIST---KSVFKKLSWICLSMVILTHSLKTFHRNWDWESEYTL 434
           LY+PSMGFC+L+  G + +     K   K L +   + +I+ + LKT  RN DW++E  L
Sbjct: 424 LYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEML 483

Query: 435 FMSALKVNKNNAKLWNNVGHALENE----------------------------------K 460
           + S +KVN   AK W N+G+ L+++                                   
Sbjct: 484 YRSGIKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENS 541

Query: 461 NFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYA 520
            F  AL Y+  A   +P    A++N G    N  RT+EA  +++    +  + +   K  
Sbjct: 542 RFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENL---KDP 598

Query: 521 ARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDF---KQAYISRGELLLKMN 577
                +  +   NL  L    +   EEA  +Y++AI   P     +  Y   GE  ++++
Sbjct: 599 HAHKSSVTSCLYNLGKLYH-EQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLS 657

Query: 578 KPLKAKEAYLKAL--ELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNP-KHKLAL 634
           K  +A+  Y+++L  + D   A L Y   +     K  +EA K F +A+EL+P K    +
Sbjct: 658 KLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRK--SEAEKLFLKAIELDPTKGNCYM 715

Query: 635 FNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKA 694
                +++E+  ++    A+K   + ++    D    FN   +      +  AE +   A
Sbjct: 716 HYGQFLLEEARLIEAAEMAKK--AAELDSTEFDV--VFNAAHMLRQASLNEAAEKYYDLA 771

Query: 695 IKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHI 736
            +L+ ++ +AL NL  +     +  KA       L+  PD +
Sbjct: 772 ARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDV 813


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
           [Homo sapiens]
          Length = 774

 Score =  215 bits (547), Expect = 2e-55
 Identities = 161/562 (28%), Positives = 272/562 (48%), Gaps = 65/562 (11%)

Query: 279 RQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSI 338
           R LT++YLL  N WLLL P  LC DW +G+IPL+E++ D+RNLAT      + +L +  +
Sbjct: 205 RFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCL 264

Query: 339 R-YSGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKIS 397
             +     K VL+ L  +  PFIPASNLFF VGFVVAERVLY+PSMG+CIL  HG  K+ 
Sbjct: 265 AAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLC 324

Query: 398 TKSVFKKLSWICLS--MVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHA 455
           T       + + +S  +++L  S KT  +N  W S  +LF S ++   +NAK+  N  + 
Sbjct: 325 TWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANF 384

Query: 456 LENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIP 515
           L+++   + A+ ++  A  + P    A  N+G   ++   T EA+  Y  A  L PQ   
Sbjct: 385 LKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRD---TAEAKMYYQRALQLHPQ--- 438

Query: 516 GKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLK 575
                      H     NL NL+++ E + EEA  L + +I   P+F  AY S   LL +
Sbjct: 439 -----------HNRALFNLGNLLKSQEKK-EEAITLLKDSIKYGPEFADAYSSLASLLAE 486

Query: 576 MNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALF 635
             +  +A+E Y   ++   +++DL  N  +  ++   P +A+ ++ +A++L+P H +A+ 
Sbjct: 487 QERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMV 546

Query: 636 NSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAI 695
           N                                     LG L     +++ AE W K+A+
Sbjct: 547 N-------------------------------------LGRLYRSLGENSMAEEWYKRAL 569

Query: 696 KLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDIL--MNQKKDI 753
           ++ A     L  L  LY  T +  +AL I +E     P   +  +    +L  M Q K+ 
Sbjct: 570 QV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKE- 627

Query: 754 LGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNI 813
             A+K    I+  +   ++    L  +Y ++++  KA   + + L L P +  +   L  
Sbjct: 628 --AEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFF 685

Query: 814 VR-DKISSSSFIEPIFPTSKIS 834
            + +++   + ++  F + +++
Sbjct: 686 TKGNQLREQNLLDKAFESYRVA 707



 Score =  100 bits (249), Expect = 6e-21
 Identities = 54/127 (42%), Positives = 80/127 (62%), Gaps = 9/127 (7%)

Query: 87  LKPMSYHLLNMIFHAVVSVIFLKVCK--LFLDNKSSVIASLLFAVHPIHTEAVTGVVGRA 144
           + P  +H +N+I H +V+++ +  C   +F +   + + +LLFAVHPIHTEAV G+VGRA
Sbjct: 1   MNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRA 60

Query: 145 ELLSSIFFLAAFLSYTRS-----KGPDNSIIWTP--IALTVFLVAVATLCKEQGITVVGI 197
           ++L+ + FL AFLSY RS      G       +P  + L++FL   A L KE GITV G+
Sbjct: 61  DVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGV 120

Query: 198 CCVYEVF 204
           C VY++F
Sbjct: 121 CLVYDLF 127



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 62/281 (22%), Positives = 131/281 (46%), Gaps = 21/281 (7%)

Query: 434 LFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNL 493
           ++ + +K   +++ L NN G  L +    E+A+ ++ QA  + P    A +N+GR Y++L
Sbjct: 496 IYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSL 555

Query: 494 NRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYR 553
                AEE Y              K A ++A  H    ++    +  N  R EEA Q+Y+
Sbjct: 556 GENSMAEEWY--------------KRALQVA--HKAEILSPLGALYYNTGRYEEALQIYQ 599

Query: 554 QAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEP 613
           +A +++P  ++  ++  ++L  M +  +A++     +  +    + +  L+ ++ + +  
Sbjct: 600 EAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENH 659

Query: 614 NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY---INEEPLDANG 670
           ++AL   ++AL+L PK    +  S +   +  +++ +    K   SY   +   P  A  
Sbjct: 660 DKALDAIDKALQLKPKDPKVI--SELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQA 717

Query: 671 YFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALL 711
           + N+G +     K   A  + ++A++L  D +    NLA L
Sbjct: 718 WMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKL 758


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score =  108 bits (269), Expect = 3e-23
 Identities = 93/385 (24%), Positives = 172/385 (44%), Gaps = 25/385 (6%)

Query: 438 ALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTK 497
           A+K N   A+ ++N+G+  +     + A++++  A  ++PD I  ++N+          +
Sbjct: 71  AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130

Query: 498 EAEESYMMAKSLMPQIIPGKK--------------------YAARIAPNHLNVYINLANL 537
            A ++Y+ A    P +   +                      A    PN    + NL  +
Sbjct: 131 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 190

Query: 538 IRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNA 597
             A +  +  A   + +A+++ P+F  AYI+ G +L +     +A  AYL+AL L  N+A
Sbjct: 191 FNA-QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHA 249

Query: 598 DLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRL 657
            +  NLA V+ E    + A+  + RA+EL P    A  N A  ++E G V    EA    
Sbjct: 250 VVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSV---AEAEDCY 306

Query: 658 LSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAK 717
            + +   P  A+   NL  +  +     EA    +KA+++  +F +A  NLA +  Q  K
Sbjct: 307 NTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGK 366

Query: 718 ELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNL 777
             +AL   +E +R  P         G+ L  + +D+ GA +C+ R ++++P+      NL
Sbjct: 367 LQEALMHYKEAIRISPTFADAYSNMGNTL-KEMQDVQGALQCYTRAIQINPAFADAHSNL 425

Query: 778 CVVYFEEKDLLKAERCLLETLALAP 802
             ++ +  ++ +A       L L P
Sbjct: 426 ASIHKDSGNIPEAIASYRTALKLKP 450



 Score =  102 bits (254), Expect = 2e-21
 Identities = 80/306 (26%), Positives = 138/306 (45%), Gaps = 18/306 (5%)

Query: 429 ESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGR 488
           E     ++ A++   N A  W+N+G     +     A+ +F +A  + P+ + A++N+G 
Sbjct: 164 EEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN 223

Query: 489 TYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEA 548
             K       A  +Y+ A SL              +PNH  V+ NLA  +   +  ++ A
Sbjct: 224 VLKEARIFDRAVAAYLRALSL--------------SPNHAVVHGNLA-CVYYEQGLIDLA 268

Query: 549 DQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHI 608
              YR+AI ++P F  AY +    L +     +A++ Y  AL L   +AD   NLA +  
Sbjct: 269 IDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKR 328

Query: 609 ELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDA 668
           E     EA++ + +ALE+ P+   A  N A V+Q+ G+++   EA       I   P  A
Sbjct: 329 EQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQ---EALMHYKEAIRISPTFA 385

Query: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728
           + Y N+G    + +    A     +AI++   F  A  NLA ++  +    +A+      
Sbjct: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445

Query: 729 LRYYPD 734
           L+  PD
Sbjct: 446 LKLKPD 451



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 24/286 (8%)

Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
           F  A+ ++ N    + N+G+ L+  + F+RA+  +L+A  + P+    H N+   Y    
Sbjct: 204 FEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQG 263

Query: 495 RTKEAEESYMMAKSLMPQIIPGK--------------------KYAARIAPNHLNVYINL 534
               A ++Y  A  L P                            A R+ P H +   NL
Sbjct: 264 LIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNL 323

Query: 535 ANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDR 594
           AN I+  +  +EEA +LYR+A+ + P+F  A+ +   +L +  K  +A   Y +A+ +  
Sbjct: 324 AN-IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP 382

Query: 595 NNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEAR 654
             AD + N+     E+++   AL+ + RA+++NP    A  N A + ++SG +   PEA 
Sbjct: 383 TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI---PEAI 439

Query: 655 KRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQAD 700
               + +  +P   + Y NL           + +  MKK + + AD
Sbjct: 440 ASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD 485



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 71/304 (23%), Positives = 130/304 (42%), Gaps = 20/304 (6%)

Query: 522 RIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLK 581
           R  P++  V + L++ I     RL+ +      AI   P   +AY + G +  +  +  +
Sbjct: 39  RQEPDNTGVLLLLSS-IHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE 97

Query: 582 AKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
           A E Y  AL L  +  D + NLA   +   +   A++ +  AL+ NP       +   ++
Sbjct: 98  AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL 157

Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWM-----KKAIK 696
           +  G ++   EA+   L  I  +P  A  + NLG +      + + EIW+     +KA+ 
Sbjct: 158 KALGRLE---EAKACYLKAIETQPNFAVAWSNLGCVF-----NAQGEIWLAIHHFEKAVT 209

Query: 697 LQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDI--LMNQKKDIL 754
           L  +F  A  NL  +  +     +A+      L   P+H    ++ G++  +  ++  I 
Sbjct: 210 LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH---AVVHGNLACVYYEQGLID 266

Query: 755 GAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP-HEEYIQRHLNI 813
            A   + R +E+ P       NL     E+  + +AE C    L L P H + +    NI
Sbjct: 267 LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANI 326

Query: 814 VRDK 817
            R++
Sbjct: 327 KREQ 330


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score =  108 bits (269), Expect = 3e-23
 Identities = 93/385 (24%), Positives = 172/385 (44%), Gaps = 25/385 (6%)

Query: 438 ALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTK 497
           A+K N   A+ ++N+G+  +     + A++++  A  ++PD I  ++N+          +
Sbjct: 81  AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 140

Query: 498 EAEESYMMAKSLMPQIIPGKK--------------------YAARIAPNHLNVYINLANL 537
            A ++Y+ A    P +   +                      A    PN    + NL  +
Sbjct: 141 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 200

Query: 538 IRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNA 597
             A +  +  A   + +A+++ P+F  AYI+ G +L +     +A  AYL+AL L  N+A
Sbjct: 201 FNA-QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHA 259

Query: 598 DLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRL 657
            +  NLA V+ E    + A+  + RA+EL P    A  N A  ++E G V    EA    
Sbjct: 260 VVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSV---AEAEDCY 316

Query: 658 LSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAK 717
            + +   P  A+   NL  +  +     EA    +KA+++  +F +A  NLA +  Q  K
Sbjct: 317 NTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGK 376

Query: 718 ELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNL 777
             +AL   +E +R  P         G+ L  + +D+ GA +C+ R ++++P+      NL
Sbjct: 377 LQEALMHYKEAIRISPTFADAYSNMGNTL-KEMQDVQGALQCYTRAIQINPAFADAHSNL 435

Query: 778 CVVYFEEKDLLKAERCLLETLALAP 802
             ++ +  ++ +A       L L P
Sbjct: 436 ASIHKDSGNIPEAIASYRTALKLKP 460



 Score =  102 bits (254), Expect = 2e-21
 Identities = 80/306 (26%), Positives = 138/306 (45%), Gaps = 18/306 (5%)

Query: 429 ESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGR 488
           E     ++ A++   N A  W+N+G     +     A+ +F +A  + P+ + A++N+G 
Sbjct: 174 EEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN 233

Query: 489 TYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEA 548
             K       A  +Y+ A SL              +PNH  V+ NLA  +   +  ++ A
Sbjct: 234 VLKEARIFDRAVAAYLRALSL--------------SPNHAVVHGNLA-CVYYEQGLIDLA 278

Query: 549 DQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHI 608
              YR+AI ++P F  AY +    L +     +A++ Y  AL L   +AD   NLA +  
Sbjct: 279 IDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKR 338

Query: 609 ELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDA 668
           E     EA++ + +ALE+ P+   A  N A V+Q+ G+++   EA       I   P  A
Sbjct: 339 EQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQ---EALMHYKEAIRISPTFA 395

Query: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728
           + Y N+G    + +    A     +AI++   F  A  NLA ++  +    +A+      
Sbjct: 396 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 455

Query: 729 LRYYPD 734
           L+  PD
Sbjct: 456 LKLKPD 461



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 24/286 (8%)

Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
           F  A+ ++ N    + N+G+ L+  + F+RA+  +L+A  + P+    H N+   Y    
Sbjct: 214 FEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQG 273

Query: 495 RTKEAEESYMMAKSLMPQIIPGK--------------------KYAARIAPNHLNVYINL 534
               A ++Y  A  L P                            A R+ P H +   NL
Sbjct: 274 LIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNL 333

Query: 535 ANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDR 594
           AN I+  +  +EEA +LYR+A+ + P+F  A+ +   +L +  K  +A   Y +A+ +  
Sbjct: 334 AN-IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP 392

Query: 595 NNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEAR 654
             AD + N+     E+++   AL+ + RA+++NP    A  N A + ++SG +   PEA 
Sbjct: 393 TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI---PEAI 449

Query: 655 KRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQAD 700
               + +  +P   + Y NL           + +  MKK + + AD
Sbjct: 450 ASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD 495



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 71/304 (23%), Positives = 130/304 (42%), Gaps = 20/304 (6%)

Query: 522 RIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLK 581
           R  P++  V + L++ I     RL+ +      AI   P   +AY + G +  +  +  +
Sbjct: 49  RQEPDNTGVLLLLSS-IHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE 107

Query: 582 AKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
           A E Y  AL L  +  D + NLA   +   +   A++ +  AL+ NP       +   ++
Sbjct: 108 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL 167

Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWM-----KKAIK 696
           +  G ++   EA+   L  I  +P  A  + NLG +      + + EIW+     +KA+ 
Sbjct: 168 KALGRLE---EAKACYLKAIETQPNFAVAWSNLGCVF-----NAQGEIWLAIHHFEKAVT 219

Query: 697 LQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDI--LMNQKKDIL 754
           L  +F  A  NL  +  +     +A+      L   P+H    ++ G++  +  ++  I 
Sbjct: 220 LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH---AVVHGNLACVYYEQGLID 276

Query: 755 GAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP-HEEYIQRHLNI 813
            A   + R +E+ P       NL     E+  + +AE C    L L P H + +    NI
Sbjct: 277 LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANI 336

Query: 814 VRDK 817
            R++
Sbjct: 337 KREQ 340


>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
          Length = 519

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 95/431 (22%), Positives = 173/431 (40%), Gaps = 33/431 (7%)

Query: 459 EKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKK 518
           E N + +L+ F     + P        V R+   L + K A E Y  A  L        +
Sbjct: 80  EGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKL-------NQ 132

Query: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
               I+ N    YI L    +A        DQL+      R D    YI  G++ L    
Sbjct: 133 KDWEISHNLGVCYIYLKQFNKAQ-------DQLHNALNLNRHDL--TYIMLGKIHLLEGD 183

Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638
             KA E Y KA+E    N +L   L +++++L    +A ++   AL  +P +  A+  + 
Sbjct: 184 LDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAG 243

Query: 639 IVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQ 698
            +MQ  G+  +     + +   + E P   N   N+GM     KK   A   +K+A  L 
Sbjct: 244 SMMQTHGDFDVALTKYRVVACAVPESPPLWN---NIGMCFFGKKKYVAAISCLKRANYLA 300

Query: 699 ADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKK 758
                 L+NL L++    +   A   L   + + P  +  L +   + +   +DI  AK+
Sbjct: 301 PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQP-KMGELYMLLAVALTNLEDIENAKR 359

Query: 759 CFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKI 818
            +   + +D  N     N  V+ + + +         +  ALA ++E +++ +++++D  
Sbjct: 360 AYAEAVHLDKCNPLVNLNYAVLLYNQGE---------KKNALAQYQE-MEKKVSLLKDNS 409

Query: 819 S---SSSFIEPIFPTSKISSVEGKKIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLG 875
           S    S  +E          V    + T+ VK+ + + + T   K +  +    SN+ LG
Sbjct: 410 SLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQQPLGSNQALG 469

Query: 876 KNGDEETPHKT 886
           +       ++T
Sbjct: 470 QAMSSAAAYRT 480



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 64/279 (22%), Positives = 110/279 (39%), Gaps = 41/279 (14%)

Query: 537 LIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNN 596
           LI   E  ++E+ +L++    + P            L  + K   A E Y +A +L++ +
Sbjct: 75  LIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKD 134

Query: 597 ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKR 656
            ++ +NL + +I LK+ N+A    + AL LN +H L                        
Sbjct: 135 WEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLT----------------------- 170

Query: 657 LLSYINEEPLDANGYFNLGML-AMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQT 715
                         Y  LG +  ++   D   E++ KKA++   +    L  L LLY Q 
Sbjct: 171 --------------YIMLGKIHLLEGDLDKAIEVY-KKAVEFSPENTELLTTLGLLYLQL 215

Query: 716 AKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKH 775
               KA   L   L Y P + K ++  G  +M    D   A   +  +    P +    +
Sbjct: 216 GIYQKAFEHLGNALTYDPTNYKAILAAGS-MMQTHGDFDVALTKYRVVACAVPESPPLWN 274

Query: 776 NLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIV 814
           N+ + +F +K  + A  CL     LAP +  I  +L +V
Sbjct: 275 NIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLV 313



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 34/167 (20%), Positives = 68/167 (40%), Gaps = 18/167 (10%)

Query: 448 LWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAK 507
           LWNN+G     +K +  A+    +A ++ P D     N+G  +  + +   A      A 
Sbjct: 272 LWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAI 331

Query: 508 SLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYI 567
           +  P++  G+ Y        + + + L NL       +E A + Y +A+ +        +
Sbjct: 332 NFQPKM--GELY--------MLLAVALTNL-----EDIENAKRAYAEAVHLDKCNPLVNL 376

Query: 568 SRGELLLKMNKPLKAKEAYL---KALELDRNNADLWYNLAIVHIELK 611
           +   LL    +   A   Y    K + L ++N+ L ++  +V +  K
Sbjct: 377 NYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEFDSEMVEMAQK 423


>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%)

Query: 435  FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
            F  A  +++ N  L +           FE A+ +F  A  + P  + A++  G +Y    
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352

Query: 495  R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551
                TK+A++ ++ A                I P ++   I+    ++A + + ++A   
Sbjct: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397

Query: 552  YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611
            +  AI   P    AY  R  + L+M     A +    A+++    A+   N  ++H  + 
Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456

Query: 612  EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
                A+K++  A+ LNPK+ LA                                     Y
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479

Query: 672  FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731
            FN G +    ++ ++A  +  KA+K   +    L N A              I   +L+ 
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525

Query: 732  YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791
            Y +                     AK+ F  ++E  P       N    Y+  K    AE
Sbjct: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564

Query: 792  RCLLETLALAPHEEYIQRHLNIVRDKI 818
              L + L+L P++  +      VR KI
Sbjct: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%)

Query: 402  FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457
            FK+ + I  +   L H+     HR  ++E     F  ALK+N      +   G++     
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352

Query: 458  NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512
            +++  ++A K FL+A H+ P  I A ++ G   +   + ++A   + +A    P+     
Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412

Query: 513  -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559
                   +  G  +AA    N          ++    +I       + A + Y+ AI++ 
Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472

Query: 560  PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619
            P +  AY + G +     +  +A + + KAL+ D  N  +  N AI +  LK+  EA ++
Sbjct: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532

Query: 620  FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
            F   +E  P      FN A       + +L  E   + LS    +P DA  Y
Sbjct: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%)

Query: 566  YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
            +++RG + +++ +   A E + +A  + R N  L +  A+ H  + E  EA+  F  AL+
Sbjct: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332

Query: 626  LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
            +NP    A         E G  +   +A+K  L  ++  P       + G       K  
Sbjct: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392

Query: 686  EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743
            +A  W    I +  D ++  A    A++  Q      A+  +   ++      + L  +G
Sbjct: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449

Query: 744  DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801
             I   M  K++   A K ++  + ++P       N   +YF  +   +A     + L   
Sbjct: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506

Query: 802  PHEEYI 807
            P  EY+
Sbjct: 1507 PENEYV 1512



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%)

Query: 437  SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496
            +A+K++   A+   N G   E   + + A+K +  A  + P    A+ N G  Y +  + 
Sbjct: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492

Query: 497  KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554
             +A + +  A    P+                N Y+ L N    N    + EEA + +  
Sbjct: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535

Query: 555  AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614
             I   P +   Y +R      + +   A+E   KAL L  N+A ++   A V  ++    
Sbjct: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595

Query: 615  EALKNFNRALEL 626
            EA+ ++N+AL+L
Sbjct: 1596 EAMADYNQALDL 1607



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%)

Query: 519  YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
            Y  +   N+   Y++ A + R  +  +  A   Y QAI   P     Y  RGE+    NK
Sbjct: 976  YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034

Query: 579  PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638
             L A + + K +  D    D      + + E +    A+++F   L ++ ++  A     
Sbjct: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093

Query: 639  IVMQ 642
            ++M+
Sbjct: 1094 LMMK 1097


>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%)

Query: 435  FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
            F  A  +++ N  L +           FE A+ +F  A  + P  + A++  G +Y    
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352

Query: 495  R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551
                TK+A++ ++ A                I P ++   I+    ++A + + ++A   
Sbjct: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397

Query: 552  YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611
            +  AI   P    AY  R  + L+M     A +    A+++    A+   N  ++H  + 
Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456

Query: 612  EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
                A+K++  A+ LNPK+ LA                                     Y
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479

Query: 672  FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731
            FN G +    ++ ++A  +  KA+K   +    L N A              I   +L+ 
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525

Query: 732  YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791
            Y +                     AK+ F  ++E  P       N    Y+  K    AE
Sbjct: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564

Query: 792  RCLLETLALAPHEEYIQRHLNIVRDKI 818
              L + L+L P++  +      VR KI
Sbjct: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%)

Query: 402  FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457
            FK+ + I  +   L H+     HR  ++E     F  ALK+N      +   G++     
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352

Query: 458  NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512
            +++  ++A K FL+A H+ P  I A ++ G   +   + ++A   + +A    P+     
Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412

Query: 513  -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559
                   +  G  +AA    N          ++    +I       + A + Y+ AI++ 
Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472

Query: 560  PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619
            P +  AY + G +     +  +A + + KAL+ D  N  +  N AI +  LK+  EA ++
Sbjct: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532

Query: 620  FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
            F   +E  P      FN A       + +L  E   + LS    +P DA  Y
Sbjct: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%)

Query: 566  YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
            +++RG + +++ +   A E + +A  + R N  L +  A+ H  + E  EA+  F  AL+
Sbjct: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332

Query: 626  LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
            +NP    A         E G  +   +A+K  L  ++  P       + G       K  
Sbjct: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392

Query: 686  EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743
            +A  W    I +  D ++  A    A++  Q      A+  +   ++      + L  +G
Sbjct: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449

Query: 744  DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801
             I   M  K++   A K ++  + ++P       N   +YF  +   +A     + L   
Sbjct: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506

Query: 802  PHEEYI 807
            P  EY+
Sbjct: 1507 PENEYV 1512



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%)

Query: 437  SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496
            +A+K++   A+   N G   E   + + A+K +  A  + P    A+ N G  Y +  + 
Sbjct: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492

Query: 497  KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554
             +A + +  A    P+                N Y+ L N    N    + EEA + +  
Sbjct: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535

Query: 555  AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614
             I   P +   Y +R      + +   A+E   KAL L  N+A ++   A V  ++    
Sbjct: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595

Query: 615  EALKNFNRALEL 626
            EA+ ++N+AL+L
Sbjct: 1596 EAMADYNQALDL 1607



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%)

Query: 519  YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
            Y  +   N+   Y++ A + R  +  +  A   Y QAI   P     Y  RGE+    NK
Sbjct: 976  YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034

Query: 579  PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638
             L A + + K +  D    D      + + E +    A+++F   L ++ ++  A     
Sbjct: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093

Query: 639  IVMQ 642
            ++M+
Sbjct: 1094 LMMK 1097


>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
            sapiens]
          Length = 1614

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%)

Query: 435  FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
            F  A  +++ N  L +           FE A+ +F  A  + P  + A++  G +Y    
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352

Query: 495  R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551
                TK+A++ ++ A                I P ++   I+    ++A + + ++A   
Sbjct: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397

Query: 552  YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611
            +  AI   P    AY  R  + L+M     A +    A+++    A+   N  ++H  + 
Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456

Query: 612  EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
                A+K++  A+ LNPK+ LA                                     Y
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479

Query: 672  FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731
            FN G +    ++ ++A  +  KA+K   +    L N A              I   +L+ 
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525

Query: 732  YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791
            Y +                     AK+ F  ++E  P       N    Y+  K    AE
Sbjct: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564

Query: 792  RCLLETLALAPHEEYIQRHLNIVRDKI 818
              L + L+L P++  +      VR KI
Sbjct: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%)

Query: 402  FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457
            FK+ + I  +   L H+     HR  ++E     F  ALK+N      +   G++     
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352

Query: 458  NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512
            +++  ++A K FL+A H+ P  I A ++ G   +   + ++A   + +A    P+     
Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412

Query: 513  -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559
                   +  G  +AA    N          ++    +I       + A + Y+ AI++ 
Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472

Query: 560  PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619
            P +  AY + G +     +  +A + + KAL+ D  N  +  N AI +  LK+  EA ++
Sbjct: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532

Query: 620  FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
            F   +E  P      FN A       + +L  E   + LS    +P DA  Y
Sbjct: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%)

Query: 566  YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
            +++RG + +++ +   A E + +A  + R N  L +  A+ H  + E  EA+  F  AL+
Sbjct: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332

Query: 626  LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
            +NP    A         E G  +   +A+K  L  ++  P       + G       K  
Sbjct: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392

Query: 686  EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743
            +A  W    I +  D ++  A    A++  Q      A+  +   ++      + L  +G
Sbjct: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449

Query: 744  DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801
             I   M  K++   A K ++  + ++P       N   +YF  +   +A     + L   
Sbjct: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506

Query: 802  PHEEYI 807
            P  EY+
Sbjct: 1507 PENEYV 1512



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%)

Query: 437  SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496
            +A+K++   A+   N G   E   + + A+K +  A  + P    A+ N G  Y +  + 
Sbjct: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492

Query: 497  KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554
             +A + +  A    P+                N Y+ L N    N    + EEA + +  
Sbjct: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535

Query: 555  AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614
             I   P +   Y +R      + +   A+E   KAL L  N+A ++   A V  ++    
Sbjct: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595

Query: 615  EALKNFNRALEL 626
            EA+ ++N+AL+L
Sbjct: 1596 EAMADYNQALDL 1607



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%)

Query: 519  YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
            Y  +   N+   Y++ A + R  +  +  A   Y QAI   P     Y  RGE+    NK
Sbjct: 976  YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034

Query: 579  PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638
             L A + + K +  D    D      + + E +    A+++F   L ++ ++  A     
Sbjct: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093

Query: 639  IVMQ 642
            ++M+
Sbjct: 1094 LMMK 1097


>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
           A [Homo sapiens]
          Length = 608

 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 49/209 (23%), Positives = 91/209 (43%), Gaps = 14/209 (6%)

Query: 518 KYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMN 577
           KY A         Y+ + N   A +  L++   L    + +R +   A I RG + ++  
Sbjct: 326 KYMAEALLLRATFYLLIGNA-NAAKPDLDKVISLKEANVKLRAN---ALIKRGSMYMQQQ 381

Query: 578 KPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKL----- 632
           +PL + + +  A ++D  NAD++++   + I L +  EA+ +F+  + L P+  L     
Sbjct: 382 QPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQK 441

Query: 633 --ALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIW 690
             AL+  A     S +++    A K     I + P  A GY        D ++  +A+  
Sbjct: 442 CFALYRQAYTGNNSSQIQ---AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEM 498

Query: 691 MKKAIKLQADFRSALFNLALLYSQTAKEL 719
             K I L+ D  +   +  LL  Q  ++L
Sbjct: 499 YDKCIDLEPDNATTYVHKGLLQLQWKQDL 527



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 24/88 (27%), Positives = 47/88 (53%), Gaps = 3/88 (3%)

Query: 541 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPL-KAKEAYLKALELDRNNADL 599
           ++ +  +AD++Y + I + PD    Y+ +G L L+  + L +  E   KA+E+D N  D 
Sbjct: 488 DQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEID-NKCDF 546

Query: 600 WYN-LAIVHIELKEPNEALKNFNRALEL 626
            Y  +  + ++     +A+  FN+A+ L
Sbjct: 547 AYETMGTIEVQRGNMEKAIDMFNKAINL 574



 Score = 37.4 bits (85), Expect = 0.064
 Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 5/83 (6%)

Query: 561 DFKQAYISRGELLLKMNKPLKAKEAYLKALEL--DRNNADL---WYNLAIVHIELKEPNE 615
           D  QA  ++G    K  K  +A + Y +A+ L     N DL   + N A    +L++  E
Sbjct: 112 DRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKE 171

Query: 616 ALKNFNRALELNPKHKLALFNSA 638
             ++  +A+ELNPK+  ALF  A
Sbjct: 172 VAQDCTKAVELNPKYVKALFRRA 194


>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
           sapiens]
          Length = 830

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 41/156 (26%), Positives = 77/156 (49%), Gaps = 4/156 (2%)

Query: 520 AARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKP 579
           A ++ PN+   Y  L +     E  L++A   +R AI + P    A+   G +  K  K 
Sbjct: 599 AIQVDPNYAYAYTLLGHEFVLTEE-LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKF 657

Query: 580 LKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
             A+  + KAL+++  ++ L  ++ +V   LK+  +AL   N+A+ ++PK+ L  F+ A 
Sbjct: 658 SLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRAS 717

Query: 640 VMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLG 675
           V+  + + K   +  + L   + +E L    YF +G
Sbjct: 718 VLFANEKYKSALQELEELKQIVPKESL---VYFLIG 750



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 57/275 (20%), Positives = 115/275 (41%), Gaps = 28/275 (10%)

Query: 428 WESEYTLFMSALK-----VNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGA 482
           W  +  + +S L      ++KN+ + W   G+    ++  + A+K+F +A  V P+   A
Sbjct: 550 WHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYA 609

Query: 483 HMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE 542
           +  +G  +     T+E +++    ++           A R+ P H N +  L  +I   +
Sbjct: 610 YTLLGHEFV---LTEELDKALACFRN-----------AIRVNPRHYNAWYGL-GMIYYKQ 654

Query: 543 SRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYN 602
            +   A+  +++A+ + P         G +   + K  KA +   KA+ +D  N    ++
Sbjct: 655 EKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFH 714

Query: 603 LAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYIN 662
            A V    ++   AL+      ++ PK  L  F    V ++ G+  L       L+++  
Sbjct: 715 RASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHL------ALMNFSW 768

Query: 663 EEPLDANGYFNLGMLAMDDK--KDNEAEIWMKKAI 695
              LD  G  N    A+D +   D+E  I  ++ I
Sbjct: 769 AMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQI 803



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 32/141 (22%), Positives = 64/141 (45%), Gaps = 7/141 (4%)

Query: 591 ELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLA--LFNSAIVMQESGEVK 648
           ++D+N+ + W          +E + A+K F RA++++P +  A  L     V+ E  +  
Sbjct: 567 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD-- 624

Query: 649 LRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708
              +A     + I   P   N ++ LGM+    +K + AE+  +KA+ +       L ++
Sbjct: 625 ---KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 681

Query: 709 ALLYSQTAKELKALPILEELL 729
            ++     K  KAL  L + +
Sbjct: 682 GVVQHALKKSEKALDTLNKAI 702



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 44/227 (19%), Positives = 86/227 (37%), Gaps = 38/227 (16%)

Query: 548 ADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVH 607
           A + +++AI + P++  AY   G   +   +  KA   +  A+ ++  + + WY L +++
Sbjct: 592 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 651

Query: 608 IELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLD 667
            + ++ + A  +F +AL++NP+  + L +  +V                           
Sbjct: 652 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHAL----------------------- 688

Query: 668 ANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEE 727
                         KK  +A   + KAI +        F+ A +     K   AL  LEE
Sbjct: 689 --------------KKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEE 734

Query: 728 LLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGK 774
           L +  P       L G +     +  L A   F   +++DP     +
Sbjct: 735 LKQIVPKESLVYFLIGKVYKKLGQTHL-ALMNFSWAMDLDPKGANNQ 780



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 18/102 (17%), Positives = 47/102 (46%), Gaps = 3/102 (2%)

Query: 721 ALPILEELLRYYPDHIKGLILKG-DILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCV 779
           A+   +  ++  P++     L G + ++ ++ D   A  CF   + ++P +    + L +
Sbjct: 592 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD--KALACFRNAIRVNPRHYNAWYGLGM 649

Query: 780 VYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSS 821
           +Y++++    AE    + L + P    +  H+ +V+  +  S
Sbjct: 650 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 691


>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 41/156 (26%), Positives = 77/156 (49%), Gaps = 4/156 (2%)

Query: 520 AARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKP 579
           A ++ PN+   Y  L +     E  L++A   +R AI + P    A+   G +  K  K 
Sbjct: 593 AIQVDPNYAYAYTLLGHEFVLTEE-LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKF 651

Query: 580 LKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
             A+  + KAL+++  ++ L  ++ +V   LK+  +AL   N+A+ ++PK+ L  F+ A 
Sbjct: 652 SLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRAS 711

Query: 640 VMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLG 675
           V+  + + K   +  + L   + +E L    YF +G
Sbjct: 712 VLFANEKYKSALQELEELKQIVPKESL---VYFLIG 744



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 57/275 (20%), Positives = 115/275 (41%), Gaps = 28/275 (10%)

Query: 428 WESEYTLFMSALK-----VNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGA 482
           W  +  + +S L      ++KN+ + W   G+    ++  + A+K+F +A  V P+   A
Sbjct: 544 WHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYA 603

Query: 483 HMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE 542
           +  +G  +     T+E +++    ++           A R+ P H N +  L  +I   +
Sbjct: 604 YTLLGHEFV---LTEELDKALACFRN-----------AIRVNPRHYNAWYGL-GMIYYKQ 648

Query: 543 SRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYN 602
            +   A+  +++A+ + P         G +   + K  KA +   KA+ +D  N    ++
Sbjct: 649 EKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFH 708

Query: 603 LAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYIN 662
            A V    ++   AL+      ++ PK  L  F    V ++ G+  L       L+++  
Sbjct: 709 RASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHL------ALMNFSW 762

Query: 663 EEPLDANGYFNLGMLAMDDK--KDNEAEIWMKKAI 695
              LD  G  N    A+D +   D+E  I  ++ I
Sbjct: 763 AMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQI 797



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 32/141 (22%), Positives = 64/141 (45%), Gaps = 7/141 (4%)

Query: 591 ELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLA--LFNSAIVMQESGEVK 648
           ++D+N+ + W          +E + A+K F RA++++P +  A  L     V+ E  +  
Sbjct: 561 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD-- 618

Query: 649 LRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708
              +A     + I   P   N ++ LGM+    +K + AE+  +KA+ +       L ++
Sbjct: 619 ---KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675

Query: 709 ALLYSQTAKELKALPILEELL 729
            ++     K  KAL  L + +
Sbjct: 676 GVVQHALKKSEKALDTLNKAI 696



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 44/227 (19%), Positives = 86/227 (37%), Gaps = 38/227 (16%)

Query: 548 ADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVH 607
           A + +++AI + P++  AY   G   +   +  KA   +  A+ ++  + + WY L +++
Sbjct: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 645

Query: 608 IELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLD 667
            + ++ + A  +F +AL++NP+  + L +  +V                           
Sbjct: 646 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHAL----------------------- 682

Query: 668 ANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEE 727
                         KK  +A   + KAI +        F+ A +     K   AL  LEE
Sbjct: 683 --------------KKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEE 728

Query: 728 LLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGK 774
           L +  P       L G +     +  L A   F   +++DP     +
Sbjct: 729 LKQIVPKESLVYFLIGKVYKKLGQTHL-ALMNFSWAMDLDPKGANNQ 774



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 18/102 (17%), Positives = 47/102 (46%), Gaps = 3/102 (2%)

Query: 721 ALPILEELLRYYPDHIKGLILKG-DILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCV 779
           A+   +  ++  P++     L G + ++ ++ D   A  CF   + ++P +    + L +
Sbjct: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD--KALACFRNAIRVNPRHYNAWYGLGM 643

Query: 780 VYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSS 821
           +Y++++    AE    + L + P    +  H+ +V+  +  S
Sbjct: 644 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 685


>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
          Length = 1173

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 103/498 (20%), Positives = 188/498 (37%), Gaps = 80/498 (16%)

Query: 444 NNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHM------NVGRTYKNLNRTK 497
           ++ + W  +   LE + + + AL  +  AT +  + + A +      NVG  +  L    
Sbjct: 410 DDVEAWIELAQILE-QTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLG 468

Query: 498 EAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLA------NLIRANESRLE--EAD 549
           EA++ ++ +              A+    H   Y N        NL R  E+  E  EA+
Sbjct: 469 EAKKYFLASLD-----------RAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAE 517

Query: 550 QLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIE 609
           +LY+  +   P++   Y+  G +        +A + + +AL++++++ D W  +  +H+ 
Sbjct: 518 KLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLA 577

Query: 610 LKEPNEALKNFNRAL-----ELNPKHKLALFNSAIVMQESGEVKLRPEARKR-----LLS 659
            +E     K F R L     + +    LAL N  + +Q   +     E  KR     L  
Sbjct: 578 KQEWGPGQKKFERILKQPSTQSDTYSMLALGN--VWLQTLHQPTRDREKEKRHQDRALAI 635

Query: 660 YINEEPLDANGYF---NLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTA 716
           Y      DA   +    +G +        EA     +  +  AD      NLA +Y +  
Sbjct: 636 YKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQK 695

Query: 717 KELKALPILEELLRYYPDH--------IKGLILKGDILMNQKKDILGAKKCFERILEMDP 768
           + + A+ + E  LR +  H        +   + K   L   K+ +L A+        + P
Sbjct: 696 QYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKAR-------HVAP 748

Query: 769 SNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIF 828
           S+     N+ +V              L T  L   +  ++  LN V++   +  +     
Sbjct: 749 SDTVLMFNVALVLQR-----------LATSVLKDEKSNLKEVLNAVKELELAHRYF---- 793

Query: 829 PTSKISSVEGKKIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTK 888
             S +S V G K+  +           T+  + SD  SQ++ +    +  DEE      K
Sbjct: 794 --SYLSKV-GDKMRFDLA------LAATEARQCSDLLSQAQYHVARARKQDEEERELRAK 844

Query: 889 DIKEIEKKRVAALKRLEE 906
             +E E  R   LK  EE
Sbjct: 845 QEQEKELLRQKLLKEQEE 862



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 56/274 (20%), Positives = 114/274 (41%), Gaps = 15/274 (5%)

Query: 524 APNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFK-QAYISRGELLLKMNKPLKA 582
           +PN++   +  A  I  N+     A   Y++A+   P    +  +  G   +K+NK  KA
Sbjct: 159 SPNNIPALLGKA-CISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKA 217

Query: 583 KEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN----FNRALELNPKHKLALFNSA 638
           + A+ +ALEL+         LA++ +  KE  +++KN     +RA  ++P + + L + A
Sbjct: 218 RLAFSRALELNSKCVGALVGLAVLELNNKEA-DSIKNGVQLLSRAYTIDPSNPMVLNHLA 276

Query: 639 IVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLG-MLAMDDKKDNEAEIWMKKAIKL 697
                  +                 E + A   + L     + +  D   + + +     
Sbjct: 277 NHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFA 336

Query: 698 QADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILM----NQKKDI 753
            + F    F L  +Y     +  A    E++L+ YP++ + + + G +       +K+DI
Sbjct: 337 SSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDI 396

Query: 754 LGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDL 787
             AK   +++ E  P +V+    L  +  E+ D+
Sbjct: 397 --AKGHLKKVTEQYPDDVEAWIELAQI-LEQTDI 427



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 55/270 (20%), Positives = 114/270 (42%), Gaps = 23/270 (8%)

Query: 434 LFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNL 493
           L+ + L+ + N    +  +G    ++ NF  A  +F +A  +  D   A   +G  +   
Sbjct: 519 LYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAK 578

Query: 494 NRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEE-ADQLY 552
                 ++ +   + L         Y+     N     ++     R  E R ++ A  +Y
Sbjct: 579 QEWGPGQKKF--ERILKQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIY 636

Query: 553 RQAISMRPDFKQAYISRGELLLKMNKPL--KAKEAYLKALELDRNNADLWYNLAIVHIEL 610
           +Q +  R D K  Y + G   +  +K    +A++ + +  E   + +D+W NLA +++E 
Sbjct: 637 KQVL--RNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQ 694

Query: 611 KEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEV----KLRPEARKRLLSYINEEPL 666
           K+   A++ +   L    KH+    N+ +V+  +  +    KL+ E ++ LL   +  P 
Sbjct: 695 KQYISAVQMYENCLRKFYKHQ----NTEVVLYLARALFKCGKLQ-ECKQTLLKARHVAPS 749

Query: 667 DANGYFNLGML-------AMDDKKDNEAEI 689
           D    FN+ ++        + D+K N  E+
Sbjct: 750 DTVLMFNVALVLQRLATSVLKDEKSNLKEV 779


>gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo
           sapiens]
          Length = 1347

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 26/215 (12%)

Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQ- 476
           F  N D++S    F  AL        +NA++  ++ H  E ++ +  A + + Q    + 
Sbjct: 174 FKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEN 233

Query: 477 -PDDIGAHM--NVGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHL 528
            P  + A +   +G  + N++      TKE+     + KSL               PN  
Sbjct: 234 LPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD------------PNSG 281

Query: 529 NVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLK 588
             +  L     ++  ++++A   YRQ+I         + S G L  + N+P+ A +AY+ 
Sbjct: 282 QSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340

Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623
           A++LD  +A  W +L  ++    +P +A+K +  A
Sbjct: 341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375


>gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo
           sapiens]
          Length = 1079

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 26/215 (12%)

Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQ- 476
           F  N D++S    F  AL        +NA++  ++ H  E ++ +  A + + Q    + 
Sbjct: 174 FKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEN 233

Query: 477 -PDDIGAHM--NVGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHL 528
            P  + A +   +G  + N++      TKE+     + KSL               PN  
Sbjct: 234 LPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD------------PNSG 281

Query: 529 NVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLK 588
             +  L     ++  ++++A   YRQ+I         + S G L  + N+P+ A +AY+ 
Sbjct: 282 QSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340

Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623
           A++LD  +A  W +L  ++    +P +A+K +  A
Sbjct: 341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375


>gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo
           sapiens]
          Length = 1240

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 26/215 (12%)

Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQ- 476
           F  N D++S    F  AL        +NA++  ++ H  E ++ +  A + + Q    + 
Sbjct: 174 FKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEN 233

Query: 477 -PDDIGAHM--NVGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHL 528
            P  + A +   +G  + N++      TKE+     + KSL               PN  
Sbjct: 234 LPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD------------PNSG 281

Query: 529 NVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLK 588
             +  L     ++  ++++A   YRQ+I         + S G L  + N+P+ A +AY+ 
Sbjct: 282 QSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340

Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623
           A++LD  +A  W +L  ++    +P +A+K +  A
Sbjct: 341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375


>gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X
           chromosome [Homo sapiens]
          Length = 1401

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 49/217 (22%), Positives = 95/217 (43%), Gaps = 30/217 (13%)

Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQP 477
           F  N D+ES    F  AL        +NA++  ++ H  E ++ +  A + + Q   +Q 
Sbjct: 177 FKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQL--LQT 234

Query: 478 DDIGAHMN------VGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPN 526
           +++ A +       +G  +  ++      TKE+     + KSL               PN
Sbjct: 235 ENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEAD------------PN 282

Query: 527 HLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAY 586
               +  L     ++  ++++A   YRQ+I         + S G L  + N+P+ A +AY
Sbjct: 283 SGQSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAY 341

Query: 587 LKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623
           + A++LD  +A  W +L  ++    +P +A+K +  A
Sbjct: 342 ICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 378


>gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens]
          Length = 626

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 27/88 (30%), Positives = 45/88 (51%)

Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
           FH + ++      F +AL V   +  LWN +G  L N    E A++ + +A  +QP  I 
Sbjct: 484 FHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIR 543

Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
           +  N+G +  NL   +EA  +++ A SL
Sbjct: 544 SRYNLGISCINLGAYREAVSNFLTALSL 571



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 50/230 (21%), Positives = 92/230 (40%), Gaps = 32/230 (13%)

Query: 434 LFM-SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKN 492
           LFM +A+  +  +A+ W  +G      +N + A+    +   +QP+++ A M +  +Y N
Sbjct: 347 LFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTN 406

Query: 493 LNRTKEAEES---YMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEAD 549
               ++A ++   ++        ++  KK +  +        ++ + L    E  LE A 
Sbjct: 407 TGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAH 466

Query: 550 Q----------------------------LYRQAISMRPDFKQAYISRGELLLKMNKPLK 581
           Q                             +  A+++RP+    +   G  L   ++  +
Sbjct: 467 QNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEE 526

Query: 582 AKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
           A EAY +ALE+        YNL I  I L    EA+ NF  AL L  K +
Sbjct: 527 AVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSR 576



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 18/75 (24%), Positives = 40/75 (53%)

Query: 661 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK 720
           I ++P DA  +  LG+   +++ +  A + +++ ++LQ +   AL  LA+ Y+ T  +  
Sbjct: 353 ILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQD 412

Query: 721 ALPILEELLRYYPDH 735
           A   L+  ++  P +
Sbjct: 413 ACDALKNWIKQNPKY 427



 Score = 31.6 bits (70), Expect = 3.5
 Identities = 34/175 (19%), Positives = 66/175 (37%), Gaps = 23/175 (13%)

Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
           +W  +   +   +K  K +  L   +  +  +    E   + +L+A H   D I   +  
Sbjct: 419 NWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQT 478

Query: 487 G-----RTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRAN 541
           G           NR  +A  +                 A  + P   +++  L   + AN
Sbjct: 479 GLGVLFHLSGEFNRAIDAFNA-----------------ALTVRPEDYSLWNRLGATL-AN 520

Query: 542 ESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNN 596
             R EEA + Y +A+ ++P F ++  + G   + +    +A   +L AL L R +
Sbjct: 521 GDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKS 575



 Score = 31.2 bits (69), Expect = 4.6
 Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 3/77 (3%)

Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVK 648
           A+  D  +A+ W  L I   E +    A+    R LEL P +  AL   A+    +G   
Sbjct: 352 AILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGH-- 409

Query: 649 LRPEARKRLLSYINEEP 665
            + +A   L ++I + P
Sbjct: 410 -QQDACDALKNWIKQNP 425


>gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo
           sapiens]
          Length = 639

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 26/88 (29%), Positives = 46/88 (52%)

Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
           F+ + +++     F +AL V  N+  LWN +G  L N    E A+  + +A  +QP  I 
Sbjct: 498 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 557

Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
           +  N+G +  NL   +EA E ++ A ++
Sbjct: 558 SRYNLGISCINLGAHREAVEHFLEALNM 585



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%)

Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
           A R+ P  ++  +     +  N S   ++A   +  A+S+RP+    +   G  L   N+
Sbjct: 478 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 537

Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
             +A  AY +ALEL        YNL I  I L    EA+++F  AL +  K +
Sbjct: 538 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 590



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%)

Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
           D  +   LF +A++ +  + + W  +G      +    A+    +   ++PD+  A M +
Sbjct: 350 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 409

Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540
             ++ N +  ++A E+        P     + P ++ A  A + P+       L +L+  
Sbjct: 410 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 463

Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
           ++S   E  +L+  A+ + P           G L     +  KA + +  AL +  N+  
Sbjct: 464 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 523

Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
           LW  L        +  EA+  + RALEL P +  + +N  I
Sbjct: 524 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 564


>gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo
           sapiens]
          Length = 639

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 26/88 (29%), Positives = 46/88 (52%)

Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
           F+ + +++     F +AL V  N+  LWN +G  L N    E A+  + +A  +QP  I 
Sbjct: 498 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 557

Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
           +  N+G +  NL   +EA E ++ A ++
Sbjct: 558 SRYNLGISCINLGAHREAVEHFLEALNM 585



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%)

Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
           A R+ P  ++  +     +  N S   ++A   +  A+S+RP+    +   G  L   N+
Sbjct: 478 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 537

Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
             +A  AY +ALEL        YNL I  I L    EA+++F  AL +  K +
Sbjct: 538 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 590



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%)

Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
           D  +   LF +A++ +  + + W  +G      +    A+    +   ++PD+  A M +
Sbjct: 350 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 409

Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540
             ++ N +  ++A E+        P     + P ++ A  A + P+       L +L+  
Sbjct: 410 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 463

Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
           ++S   E  +L+  A+ + P           G L     +  KA + +  AL +  N+  
Sbjct: 464 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 523

Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
           LW  L        +  EA+  + RALEL P +  + +N  I
Sbjct: 524 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 564


>gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo
           sapiens]
          Length = 602

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 26/88 (29%), Positives = 46/88 (52%)

Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
           F+ + +++     F +AL V  N+  LWN +G  L N    E A+  + +A  +QP  I 
Sbjct: 461 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 520

Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
           +  N+G +  NL   +EA E ++ A ++
Sbjct: 521 SRYNLGISCINLGAHREAVEHFLEALNM 548



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%)

Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
           A R+ P  ++  +     +  N S   ++A   +  A+S+RP+    +   G  L   N+
Sbjct: 441 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 500

Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
             +A  AY +ALEL        YNL I  I L    EA+++F  AL +  K +
Sbjct: 501 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 553



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%)

Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
           D  +   LF +A++ +  + + W  +G      +    A+    +   ++PD+  A M +
Sbjct: 313 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 372

Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540
             ++ N +  ++A E+        P     + P ++ A  A + P+       L +L+  
Sbjct: 373 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 426

Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
           ++S   E  +L+  A+ + P           G L     +  KA + +  AL +  N+  
Sbjct: 427 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 486

Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
           LW  L        +  EA+  + RALEL P +  + +N  I
Sbjct: 487 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 527


>gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo
           sapiens]
          Length = 654

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 26/88 (29%), Positives = 46/88 (52%)

Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
           F+ + +++     F +AL V  N+  LWN +G  L N    E A+  + +A  +QP  I 
Sbjct: 513 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 572

Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
           +  N+G +  NL   +EA E ++ A ++
Sbjct: 573 SRYNLGISCINLGAHREAVEHFLEALNM 600



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%)

Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
           A R+ P  ++  +     +  N S   ++A   +  A+S+RP+    +   G  L   N+
Sbjct: 493 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 552

Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
             +A  AY +ALEL        YNL I  I L    EA+++F  AL +  K +
Sbjct: 553 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 605



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%)

Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
           D  +   LF +A++ +  + + W  +G      +    A+    +   ++PD+  A M +
Sbjct: 365 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 424

Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540
             ++ N +  ++A E+        P     + P ++ A  A + P+       L +L+  
Sbjct: 425 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 478

Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
           ++S   E  +L+  A+ + P           G L     +  KA + +  AL +  N+  
Sbjct: 479 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 538

Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
           LW  L        +  EA+  + RALEL P +  + +N  I
Sbjct: 539 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 579


>gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo
           sapiens]
          Length = 631

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 26/88 (29%), Positives = 46/88 (52%)

Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
           F+ + +++     F +AL V  N+  LWN +G  L N    E A+  + +A  +QP  I 
Sbjct: 490 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 549

Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
           +  N+G +  NL   +EA E ++ A ++
Sbjct: 550 SRYNLGISCINLGAHREAVEHFLEALNM 577



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%)

Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
           A R+ P  ++  +     +  N S   ++A   +  A+S+RP+    +   G  L   N+
Sbjct: 470 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 529

Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
             +A  AY +ALEL        YNL I  I L    EA+++F  AL +  K +
Sbjct: 530 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 582



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%)

Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
           D  +   LF +A++ +  + + W  +G      +    A+    +   ++PD+  A M +
Sbjct: 342 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 401

Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540
             ++ N +  ++A E+        P     + P ++ A  A + P+       L +L+  
Sbjct: 402 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 455

Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
           ++S   E  +L+  A+ + P           G L     +  KA + +  AL +  N+  
Sbjct: 456 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 515

Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
           LW  L        +  EA+  + RALEL P +  + +N  I
Sbjct: 516 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 556


>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
           sapiens]
          Length = 860

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 46/201 (22%), Positives = 82/201 (40%), Gaps = 24/201 (11%)

Query: 456 LENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIP 515
           L + KN E AL    +   ++PD              L R  EA      A  L P    
Sbjct: 192 LHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPS--- 248

Query: 516 GKKYAAR-----IAPNHLNVYINLANLIRANESR----------------LEEADQLYRQ 554
            + Y  R     I+ ++   + +    +  N+++                L+EA + +++
Sbjct: 249 ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKE 308

Query: 555 AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614
           A+  + DF  AY S G+   ++     A E++ KAL L++N+        ++        
Sbjct: 309 ALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQ 368

Query: 615 EALKNFNRALELNPKHKLALF 635
           EALKNF R L+L P +++  +
Sbjct: 369 EALKNFKRCLQLEPYNEVCQY 389



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 45/217 (20%), Positives = 93/217 (42%), Gaps = 39/217 (17%)

Query: 554 QAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEP 613
           + I++ PD  + +  R E+L  + +  +A     KA++L + +A L+ +   ++   ++ 
Sbjct: 207 RVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQL-QPSARLYRHRGTLYFISEDY 265

Query: 614 NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFN 673
             A ++F ++LELN    +A+    +                               +F+
Sbjct: 266 ATAHEDFQQSLELNKNQPIAMLYKGLT------------------------------FFH 295

Query: 674 LGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYP 733
            G+L        EA    K+A+K + DF  A  +L   Y +      A    ++ L    
Sbjct: 296 RGLL-------KEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 348

Query: 734 DHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSN 770
           +H++ L L+G +++     +  A K F+R L+++P N
Sbjct: 349 NHVQTLQLRG-MMLYHHGSLQEALKNFKRCLQLEPYN 384


>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
           sapiens]
          Length = 515

 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%)

Query: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524
           AL  F Q     P ++     + R Y+ +N    A E Y   K ++ Q     +  A I 
Sbjct: 277 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 333

Query: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584
            NH                + E A + YR+ + M     Q + + G       +      
Sbjct: 334 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 381

Query: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
           ++ +AL L  N    AD+WYNL  V + + + N A + F  AL  N  H  A  N A++ 
Sbjct: 382 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 441

Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678
              G V+   +AR  L +  +  P     +FN   ++
Sbjct: 442 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 475



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%)

Query: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529
           L   H Q  D    + +G+ Y  L   +EAE+ +  A     +++    Y A+       
Sbjct: 215 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 266

Query: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589
           VY++L   + A          L++Q +   P           +  +MN    A E Y + 
Sbjct: 267 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 318

Query: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649
           L+ D  + +    +   H    +P  AL+ + R L++   +     N  +    + +  +
Sbjct: 319 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 378

Query: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709
              + +R LS    E   A+ ++NLG +A+     N A    + A+    +   A  NLA
Sbjct: 379 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 438

Query: 710 LLYSQTAKELKALPILE 726
           +L  +     +A  +L+
Sbjct: 439 VLEMRKGHVEQARALLQ 455


>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
           sapiens]
          Length = 475

 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%)

Query: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524
           AL  F Q     P ++     + R Y+ +N    A E Y   K ++ Q     +  A I 
Sbjct: 237 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 293

Query: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584
            NH                + E A + YR+ + M     Q + + G       +      
Sbjct: 294 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 341

Query: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
           ++ +AL L  N    AD+WYNL  V + + + N A + F  AL  N  H  A  N A++ 
Sbjct: 342 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 401

Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678
              G V+   +AR  L +  +  P     +FN   ++
Sbjct: 402 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 435



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%)

Query: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529
           L   H Q  D    + +G+ Y  L   +EAE+ +  A     +++    Y A+       
Sbjct: 175 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 226

Query: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589
           VY++L   + A          L++Q +   P           +  +MN    A E Y + 
Sbjct: 227 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 278

Query: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649
           L+ D  + +    +   H    +P  AL+ + R L++   +     N  +    + +  +
Sbjct: 279 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 338

Query: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709
              + +R LS    E   A+ ++NLG +A+     N A    + A+    +   A  NLA
Sbjct: 339 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 398

Query: 710 LLYSQTAKELKALPILE 726
           +L  +     +A  +L+
Sbjct: 399 VLEMRKGHVEQARALLQ 415


>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
           sapiens]
          Length = 505

 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%)

Query: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524
           AL  F Q     P ++     + R Y+ +N    A E Y   K ++ Q     +  A I 
Sbjct: 267 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 323

Query: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584
            NH                + E A + YR+ + M     Q + + G       +      
Sbjct: 324 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 371

Query: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
           ++ +AL L  N    AD+WYNL  V + + + N A + F  AL  N  H  A  N A++ 
Sbjct: 372 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 431

Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678
              G V+   +AR  L +  +  P     +FN   ++
Sbjct: 432 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 465



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%)

Query: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529
           L   H Q  D    + +G+ Y  L   +EAE+ +  A     +++    Y A+       
Sbjct: 205 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 256

Query: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589
           VY++L   + A          L++Q +   P           +  +MN    A E Y + 
Sbjct: 257 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 308

Query: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649
           L+ D  + +    +   H    +P  AL+ + R L++   +     N  +    + +  +
Sbjct: 309 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 368

Query: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709
              + +R LS    E   A+ ++NLG +A+     N A    + A+    +   A  NLA
Sbjct: 369 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 428

Query: 710 LLYSQTAKELKALPILE 726
           +L  +     +A  +L+
Sbjct: 429 VLEMRKGHVEQARALLQ 445


>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
           sapiens]
          Length = 807

 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 27/91 (29%), Positives = 49/91 (53%)

Query: 545 LEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLA 604
           L+EA + +++A+  + DF  AY S G+   ++     A E++ KAL L++N+        
Sbjct: 246 LKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRG 305

Query: 605 IVHIELKEPNEALKNFNRALELNPKHKLALF 635
           ++        EALKNF R L+L P +++  +
Sbjct: 306 MMLYHHGSLQEALKNFKRCLQLEPYNEVCQY 336



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 49/222 (22%), Positives = 94/222 (42%), Gaps = 31/222 (13%)

Query: 571 ELLLKMNKPLKAKEAYLKALELDRNNADL----------WYNLAIVH----IELKEP--- 613
           E +L   K +  ++ +  A + D  N +L           Y+ AI H    +++  P   
Sbjct: 119 EKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGR 178

Query: 614 -NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPL----DA 668
            NEA+ +  +A++L P  +L      +    S +     E  ++ L     +P+      
Sbjct: 179 INEAVNDLTKAIQLQPSARLYRHRGTLYFI-SEDYATAHEDFQQSLELNKNQPIAMLYKG 237

Query: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728
             +F+ G+L        EA    K+A+K + DF  A  +L   Y +      A    ++ 
Sbjct: 238 LTFFHRGLL-------KEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290

Query: 729 LRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSN 770
           L    +H++ L L+G +++     +  A K F+R L+++P N
Sbjct: 291 LLLNQNHVQTLQLRG-MMLYHHGSLQEALKNFKRCLQLEPYN 331


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,403,484
Number of Sequences: 37866
Number of extensions: 1338340
Number of successful extensions: 4684
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 3899
Number of HSP's gapped (non-prelim): 565
length of query: 914
length of database: 18,247,518
effective HSP length: 111
effective length of query: 803
effective length of database: 14,044,392
effective search space: 11277646776
effective search space used: 11277646776
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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