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Search of human proteins with 224809432
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224809432 transmembrane and tetratricopeptide repeat
containing 3 [Homo sapiens]
(914 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224809432 transmembrane and tetratricopeptide repeat containi... 1813 0.0
gi|118766328 transmembrane and tetratricopeptide repeat containi... 392 e-108
gi|118766330 transmembrane and tetratricopeptide repeat containi... 392 e-108
gi|22749211 transmembrane and tetratricopeptide repeat containin... 325 9e-89
gi|83415184 transmembrane and tetratricopeptide repeat containin... 215 2e-55
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 108 3e-23
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 108 3e-23
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 73 1e-12
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 59 3e-08
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 59 3e-08
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 59 3e-08
gi|54607135 translocase of outer mitochondrial membrane 70 homol... 57 8e-08
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 55 2e-07
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 55 2e-07
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 52 3e-06
gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sap... 51 4e-06
gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo sap... 51 4e-06
gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sap... 51 4e-06
gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ... 50 7e-06
gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens] 50 1e-05
gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo sap... 49 3e-05
gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo sap... 49 3e-05
gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo sap... 49 3e-05
gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo sap... 49 3e-05
gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo sapi... 49 3e-05
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 47 6e-05
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa... 47 8e-05
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa... 47 8e-05
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa... 47 8e-05
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 47 8e-05
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 1813 bits (4697), Expect = 0.0
Identities = 914/914 (100%), Positives = 914/914 (100%)
Query: 1 MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP 60
MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP
Sbjct: 1 MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP 60
Query: 61 MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS 120
MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS
Sbjct: 61 MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS 120
Query: 121 VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL 180
VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL
Sbjct: 121 VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL 180
Query: 181 VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI 240
VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI
Sbjct: 181 VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI 240
Query: 241 VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL 300
VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL
Sbjct: 241 VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL 300
Query: 301 CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI 360
CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI
Sbjct: 301 CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI 360
Query: 361 PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK 420
PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK
Sbjct: 361 PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK 420
Query: 421 TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI 480
TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI
Sbjct: 421 TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI 480
Query: 481 GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA 540
GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA
Sbjct: 481 GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA 540
Query: 541 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW 600
NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW
Sbjct: 541 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW 600
Query: 601 YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY 660
YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY
Sbjct: 601 YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY 660
Query: 661 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK 720
INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK
Sbjct: 661 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK 720
Query: 721 ALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVV 780
ALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVV
Sbjct: 721 ALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVV 780
Query: 781 YFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKK 840
YFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKK
Sbjct: 781 YFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKK 840
Query: 841 IPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAA 900
IPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAA
Sbjct: 841 IPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAA 900
Query: 901 LKRLEEIERILNGE 914
LKRLEEIERILNGE
Sbjct: 901 LKRLEEIERILNGE 914
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 392 bits (1006), Expect = e-108
Identities = 248/694 (35%), Positives = 383/694 (55%), Gaps = 49/694 (7%)
Query: 11 LIVG-VVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKS 69
L+VG V C+ S FVFDD AI++NKDL TPL L+ +DFWG+ +S SHKS
Sbjct: 24 LVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKS 83
Query: 70 YRPLTVLTFRLNYLLSE-LKPMSYHLLNMIFHAVVSVIFLKVC--------------KLF 114
YRPLTVLTFR+NY LS P+ +H++N++ H+ +SV+ + V +L
Sbjct: 84 YRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLH 143
Query: 115 LDNKSSVIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRS------KGPDNS 168
L ++S++A+LLFAVHP+HTE V GVVGRA+LL ++FFL +FL Y ++ +G +S
Sbjct: 144 LAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSS 203
Query: 169 IIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSI 228
W + L++FL AVA LCKEQGITV+G+ V+++ + + + L + K
Sbjct: 204 TFW--VLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNV--LEIVQKVLHKDKSLE 259
Query: 229 PFSMLQT---LVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTP-TRQLTFN 284
ML+ L ++ +L ++ +R +++ + P FT DNPA+ + + R + +N
Sbjct: 260 NLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYN 319
Query: 285 YLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFT-FFCFLGMLGVFSIRYSGD 343
Y +NAWLLL P LC DW+MG IPLI+S+ D R +A +FC +G++ G
Sbjct: 320 YYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGH 379
Query: 344 SSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFK 403
+ + + L + +PF+PASNLFF VGFVVAERVLY+PS+G+C+L+ G+ +S + K
Sbjct: 380 KRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKK 439
Query: 404 KLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFE 463
KL + ++ ++L+ R+ +W SE LF SAL V NAK+ N+G L ++ N
Sbjct: 440 KLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQT 499
Query: 464 RALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARI 523
A++Y+ +A + P + A N+G K N +EAEE + A +I
Sbjct: 500 AAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSL--------------AVQI 545
Query: 524 APNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAK 583
P+ ++NL +++ + R E A+Q YR AI R + Y + G L +N+ + A
Sbjct: 546 QPDFAAAWMNL-GIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDAL 604
Query: 584 EAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQE 643
A+ A L ++ W N+ I+ +A ALEL P +F+ A V+ +
Sbjct: 605 NAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGK 664
Query: 644 SGEVKLRPEARKRLLSYINEEPLDANGYFNLGML 677
S + K E+ L I P A+ + NL +L
Sbjct: 665 SQKYK---ESEALFLKAIKANPNAASYHGNLAVL 695
Score = 55.8 bits (133), Expect = 2e-07
Identities = 52/241 (21%), Positives = 107/241 (44%), Gaps = 10/241 (4%)
Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
+I+ +L+ + ++ + AL + NA + YN+ + A++ + A+
Sbjct: 451 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 510
Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
LNPK+ A+ N +++E E++ EA + L + +P A + NLG++ K+
Sbjct: 511 LNPKYVHAMNNLGNILKERNELQ---EAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFE 567
Query: 686 EAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHI---KGLILK 742
AE + AIK + + +NL LY+ + + AL P+H +I
Sbjct: 568 AAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMI-- 625
Query: 743 GDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP 802
IL++ ++ A+ LE+ P++ +L V + + ++E L+ + P
Sbjct: 626 --ILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANP 683
Query: 803 H 803
+
Sbjct: 684 N 684
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 392 bits (1006), Expect = e-108
Identities = 248/694 (35%), Positives = 383/694 (55%), Gaps = 49/694 (7%)
Query: 11 LIVG-VVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKS 69
L+VG V C+ S FVFDD AI++NKDL TPL L+ +DFWG+ +S SHKS
Sbjct: 43 LVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKS 102
Query: 70 YRPLTVLTFRLNYLLSE-LKPMSYHLLNMIFHAVVSVIFLKVC--------------KLF 114
YRPLTVLTFR+NY LS P+ +H++N++ H+ +SV+ + V +L
Sbjct: 103 YRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLH 162
Query: 115 LDNKSSVIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRS------KGPDNS 168
L ++S++A+LLFAVHP+HTE V GVVGRA+LL ++FFL +FL Y ++ +G +S
Sbjct: 163 LAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSS 222
Query: 169 IIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSI 228
W + L++FL AVA LCKEQGITV+G+ V+++ + + + L + K
Sbjct: 223 TFW--VLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNV--LEIVQKVLHKDKSLE 278
Query: 229 PFSMLQT---LVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTP-TRQLTFN 284
ML+ L ++ +L ++ +R +++ + P FT DNPA+ + + R + +N
Sbjct: 279 NLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYN 338
Query: 285 YLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFT-FFCFLGMLGVFSIRYSGD 343
Y +NAWLLL P LC DW+MG IPLI+S+ D R +A +FC +G++ G
Sbjct: 339 YYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGH 398
Query: 344 SSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFK 403
+ + + L + +PF+PASNLFF VGFVVAERVLY+PS+G+C+L+ G+ +S + K
Sbjct: 399 KRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKK 458
Query: 404 KLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFE 463
KL + ++ ++L+ R+ +W SE LF SAL V NAK+ N+G L ++ N
Sbjct: 459 KLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQT 518
Query: 464 RALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARI 523
A++Y+ +A + P + A N+G K N +EAEE + A +I
Sbjct: 519 AAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSL--------------AVQI 564
Query: 524 APNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAK 583
P+ ++NL +++ + R E A+Q YR AI R + Y + G L +N+ + A
Sbjct: 565 QPDFAAAWMNL-GIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDAL 623
Query: 584 EAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQE 643
A+ A L ++ W N+ I+ +A ALEL P +F+ A V+ +
Sbjct: 624 NAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGK 683
Query: 644 SGEVKLRPEARKRLLSYINEEPLDANGYFNLGML 677
S + K E+ L I P A+ + NL +L
Sbjct: 684 SQKYK---ESEALFLKAIKANPNAASYHGNLAVL 714
Score = 55.8 bits (133), Expect = 2e-07
Identities = 52/241 (21%), Positives = 107/241 (44%), Gaps = 10/241 (4%)
Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
+I+ +L+ + ++ + AL + NA + YN+ + A++ + A+
Sbjct: 470 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 529
Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
LNPK+ A+ N +++E E++ EA + L + +P A + NLG++ K+
Sbjct: 530 LNPKYVHAMNNLGNILKERNELQ---EAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFE 586
Query: 686 EAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHI---KGLILK 742
AE + AIK + + +NL LY+ + + AL P+H +I
Sbjct: 587 AAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMI-- 644
Query: 743 GDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP 802
IL++ ++ A+ LE+ P++ +L V + + ++E L+ + P
Sbjct: 645 --ILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANP 702
Query: 803 H 803
+
Sbjct: 703 N 703
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 325 bits (834), Expect = 9e-89
Identities = 246/822 (29%), Positives = 390/822 (47%), Gaps = 124/822 (15%)
Query: 18 ACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLT 77
A Y N+L F +DD AI N+DL P TP +F NDFWGT ++ SHKSYRPL L+
Sbjct: 13 ALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLS 72
Query: 78 FRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFL-DNKSSVIASLLFAVHPIHTEA 136
FRLN+ + L P SYHL+N++ HA V+ +F K+ L D + +A L+FA HPIHTEA
Sbjct: 73 FRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEA 132
Query: 137 VTGVVGRAELLSSIFFLAAFLSYTR--SKGPDNSIIWTPIALTVFLVAVATLCKEQGITV 194
V G+VGRA++ +S+FFL + L Y + S ++ W + + L KEQG+TV
Sbjct: 133 VAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTV 192
Query: 195 VGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRV 254
+ + VY+VF+ + + T + K L + + +L+F L+ R+
Sbjct: 193 LAVSAVYDVFVFHRLKIKQILPT---IYKRKN------LSLFLSISLLIFWGSSLLGARL 243
Query: 255 QVIQSQLPVFTRFDNPAAVSPTP-TRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIE 313
+ ++ P F+ DNPAA S + TR LTF YL N WLLL P L DW+M +PL++
Sbjct: 244 YWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLK 303
Query: 314 SLLDIRNLATFTFFCFLGMLGVFSIR------------------------------YSGD 343
++ D RNL T F+ L +L + ++ Y
Sbjct: 304 TVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNS 363
Query: 344 SSKT--------------------------VLMALCLMALPFIPASNLFFPVGFVVAERV 377
+K+ V+++L L+ +PF+PA+NLFF VGFV+AERV
Sbjct: 364 ETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERV 423
Query: 378 LYVPSMGFCILVAHGWQKIST---KSVFKKLSWICLSMVILTHSLKTFHRNWDWESEYTL 434
LY+PSMGFC+L+ G + + K K L + + +I+ + LKT RN DW++E L
Sbjct: 424 LYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEML 483
Query: 435 FMSALKVNKNNAKLWNNVGHALENE----------------------------------K 460
+ S +KVN AK W N+G+ L+++
Sbjct: 484 YRSGIKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENS 541
Query: 461 NFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYA 520
F AL Y+ A +P A++N G N RT+EA +++ + + + K
Sbjct: 542 RFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENL---KDP 598
Query: 521 ARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDF---KQAYISRGELLLKMN 577
+ + NL L + EEA +Y++AI P + Y GE ++++
Sbjct: 599 HAHKSSVTSCLYNLGKLYH-EQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLS 657
Query: 578 KPLKAKEAYLKAL--ELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNP-KHKLAL 634
K +A+ Y+++L + D A L Y + K +EA K F +A+EL+P K +
Sbjct: 658 KLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRK--SEAEKLFLKAIELDPTKGNCYM 715
Query: 635 FNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKA 694
+++E+ ++ A+K + ++ D FN + + AE + A
Sbjct: 716 HYGQFLLEEARLIEAAEMAKK--AAELDSTEFDV--VFNAAHMLRQASLNEAAEKYYDLA 771
Query: 695 IKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHI 736
+L+ ++ +AL NL + + KA L+ PD +
Sbjct: 772 ARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDV 813
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 215 bits (547), Expect = 2e-55
Identities = 161/562 (28%), Positives = 272/562 (48%), Gaps = 65/562 (11%)
Query: 279 RQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSI 338
R LT++YLL N WLLL P LC DW +G+IPL+E++ D+RNLAT + +L + +
Sbjct: 205 RFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCL 264
Query: 339 R-YSGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKIS 397
+ K VL+ L + PFIPASNLFF VGFVVAERVLY+PSMG+CIL HG K+
Sbjct: 265 AAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLC 324
Query: 398 TKSVFKKLSWICLS--MVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHA 455
T + + +S +++L S KT +N W S +LF S ++ +NAK+ N +
Sbjct: 325 TWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANF 384
Query: 456 LENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIP 515
L+++ + A+ ++ A + P A N+G ++ T EA+ Y A L PQ
Sbjct: 385 LKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRD---TAEAKMYYQRALQLHPQ--- 438
Query: 516 GKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLK 575
H NL NL+++ E + EEA L + +I P+F AY S LL +
Sbjct: 439 -----------HNRALFNLGNLLKSQEKK-EEAITLLKDSIKYGPEFADAYSSLASLLAE 486
Query: 576 MNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALF 635
+ +A+E Y ++ +++DL N + ++ P +A+ ++ +A++L+P H +A+
Sbjct: 487 QERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMV 546
Query: 636 NSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAI 695
N LG L +++ AE W K+A+
Sbjct: 547 N-------------------------------------LGRLYRSLGENSMAEEWYKRAL 569
Query: 696 KLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDIL--MNQKKDI 753
++ A L L LY T + +AL I +E P + + +L M Q K+
Sbjct: 570 QV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKE- 627
Query: 754 LGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNI 813
A+K I+ + ++ L +Y ++++ KA + + L L P + + L
Sbjct: 628 --AEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFF 685
Query: 814 VR-DKISSSSFIEPIFPTSKIS 834
+ +++ + ++ F + +++
Sbjct: 686 TKGNQLREQNLLDKAFESYRVA 707
Score = 100 bits (249), Expect = 6e-21
Identities = 54/127 (42%), Positives = 80/127 (62%), Gaps = 9/127 (7%)
Query: 87 LKPMSYHLLNMIFHAVVSVIFLKVCK--LFLDNKSSVIASLLFAVHPIHTEAVTGVVGRA 144
+ P +H +N+I H +V+++ + C +F + + + +LLFAVHPIHTEAV G+VGRA
Sbjct: 1 MNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRA 60
Query: 145 ELLSSIFFLAAFLSYTRS-----KGPDNSIIWTP--IALTVFLVAVATLCKEQGITVVGI 197
++L+ + FL AFLSY RS G +P + L++FL A L KE GITV G+
Sbjct: 61 DVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGV 120
Query: 198 CCVYEVF 204
C VY++F
Sbjct: 121 CLVYDLF 127
Score = 70.9 bits (172), Expect = 5e-12
Identities = 62/281 (22%), Positives = 131/281 (46%), Gaps = 21/281 (7%)
Query: 434 LFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNL 493
++ + +K +++ L NN G L + E+A+ ++ QA + P A +N+GR Y++L
Sbjct: 496 IYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSL 555
Query: 494 NRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYR 553
AEE Y K A ++A H ++ + N R EEA Q+Y+
Sbjct: 556 GENSMAEEWY--------------KRALQVA--HKAEILSPLGALYYNTGRYEEALQIYQ 599
Query: 554 QAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEP 613
+A +++P ++ ++ ++L M + +A++ + + + + L+ ++ + +
Sbjct: 600 EAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENH 659
Query: 614 NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY---INEEPLDANG 670
++AL ++AL+L PK + S + + +++ + K SY + P A
Sbjct: 660 DKALDAIDKALQLKPKDPKVI--SELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQA 717
Query: 671 YFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALL 711
+ N+G + K A + ++A++L D + NLA L
Sbjct: 718 WMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKL 758
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 108 bits (269), Expect = 3e-23
Identities = 93/385 (24%), Positives = 172/385 (44%), Gaps = 25/385 (6%)
Query: 438 ALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTK 497
A+K N A+ ++N+G+ + + A++++ A ++PD I ++N+ +
Sbjct: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
Query: 498 EAEESYMMAKSLMPQIIPGKK--------------------YAARIAPNHLNVYINLANL 537
A ++Y+ A P + + A PN + NL +
Sbjct: 131 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 190
Query: 538 IRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNA 597
A + + A + +A+++ P+F AYI+ G +L + +A AYL+AL L N+A
Sbjct: 191 FNA-QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHA 249
Query: 598 DLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRL 657
+ NLA V+ E + A+ + RA+EL P A N A ++E G V EA
Sbjct: 250 VVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSV---AEAEDCY 306
Query: 658 LSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAK 717
+ + P A+ NL + + EA +KA+++ +F +A NLA + Q K
Sbjct: 307 NTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGK 366
Query: 718 ELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNL 777
+AL +E +R P G+ L + +D+ GA +C+ R ++++P+ NL
Sbjct: 367 LQEALMHYKEAIRISPTFADAYSNMGNTL-KEMQDVQGALQCYTRAIQINPAFADAHSNL 425
Query: 778 CVVYFEEKDLLKAERCLLETLALAP 802
++ + ++ +A L L P
Sbjct: 426 ASIHKDSGNIPEAIASYRTALKLKP 450
Score = 102 bits (254), Expect = 2e-21
Identities = 80/306 (26%), Positives = 138/306 (45%), Gaps = 18/306 (5%)
Query: 429 ESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGR 488
E ++ A++ N A W+N+G + A+ +F +A + P+ + A++N+G
Sbjct: 164 EEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN 223
Query: 489 TYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEA 548
K A +Y+ A SL +PNH V+ NLA + + ++ A
Sbjct: 224 VLKEARIFDRAVAAYLRALSL--------------SPNHAVVHGNLA-CVYYEQGLIDLA 268
Query: 549 DQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHI 608
YR+AI ++P F AY + L + +A++ Y AL L +AD NLA +
Sbjct: 269 IDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKR 328
Query: 609 ELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDA 668
E EA++ + +ALE+ P+ A N A V+Q+ G+++ EA I P A
Sbjct: 329 EQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQ---EALMHYKEAIRISPTFA 385
Query: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728
+ Y N+G + + A +AI++ F A NLA ++ + +A+
Sbjct: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445
Query: 729 LRYYPD 734
L+ PD
Sbjct: 446 LKLKPD 451
Score = 88.2 bits (217), Expect = 3e-17
Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 24/286 (8%)
Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
F A+ ++ N + N+G+ L+ + F+RA+ +L+A + P+ H N+ Y
Sbjct: 204 FEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQG 263
Query: 495 RTKEAEESYMMAKSLMPQIIPGK--------------------KYAARIAPNHLNVYINL 534
A ++Y A L P A R+ P H + NL
Sbjct: 264 LIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNL 323
Query: 535 ANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDR 594
AN I+ + +EEA +LYR+A+ + P+F A+ + +L + K +A Y +A+ +
Sbjct: 324 AN-IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP 382
Query: 595 NNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEAR 654
AD + N+ E+++ AL+ + RA+++NP A N A + ++SG + PEA
Sbjct: 383 TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI---PEAI 439
Query: 655 KRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQAD 700
+ + +P + Y NL + + MKK + + AD
Sbjct: 440 ASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD 485
Score = 59.3 bits (142), Expect = 2e-08
Identities = 71/304 (23%), Positives = 130/304 (42%), Gaps = 20/304 (6%)
Query: 522 RIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLK 581
R P++ V + L++ I RL+ + AI P +AY + G + + + +
Sbjct: 39 RQEPDNTGVLLLLSS-IHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE 97
Query: 582 AKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
A E Y AL L + D + NLA + + A++ + AL+ NP + ++
Sbjct: 98 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL 157
Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWM-----KKAIK 696
+ G ++ EA+ L I +P A + NLG + + + EIW+ +KA+
Sbjct: 158 KALGRLE---EAKACYLKAIETQPNFAVAWSNLGCVF-----NAQGEIWLAIHHFEKAVT 209
Query: 697 LQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDI--LMNQKKDIL 754
L +F A NL + + +A+ L P+H ++ G++ + ++ I
Sbjct: 210 LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH---AVVHGNLACVYYEQGLID 266
Query: 755 GAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP-HEEYIQRHLNI 813
A + R +E+ P NL E+ + +AE C L L P H + + NI
Sbjct: 267 LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANI 326
Query: 814 VRDK 817
R++
Sbjct: 327 KREQ 330
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 108 bits (269), Expect = 3e-23
Identities = 93/385 (24%), Positives = 172/385 (44%), Gaps = 25/385 (6%)
Query: 438 ALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTK 497
A+K N A+ ++N+G+ + + A++++ A ++PD I ++N+ +
Sbjct: 81 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 140
Query: 498 EAEESYMMAKSLMPQIIPGKK--------------------YAARIAPNHLNVYINLANL 537
A ++Y+ A P + + A PN + NL +
Sbjct: 141 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 200
Query: 538 IRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNA 597
A + + A + +A+++ P+F AYI+ G +L + +A AYL+AL L N+A
Sbjct: 201 FNA-QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHA 259
Query: 598 DLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRL 657
+ NLA V+ E + A+ + RA+EL P A N A ++E G V EA
Sbjct: 260 VVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSV---AEAEDCY 316
Query: 658 LSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAK 717
+ + P A+ NL + + EA +KA+++ +F +A NLA + Q K
Sbjct: 317 NTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGK 376
Query: 718 ELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNL 777
+AL +E +R P G+ L + +D+ GA +C+ R ++++P+ NL
Sbjct: 377 LQEALMHYKEAIRISPTFADAYSNMGNTL-KEMQDVQGALQCYTRAIQINPAFADAHSNL 435
Query: 778 CVVYFEEKDLLKAERCLLETLALAP 802
++ + ++ +A L L P
Sbjct: 436 ASIHKDSGNIPEAIASYRTALKLKP 460
Score = 102 bits (254), Expect = 2e-21
Identities = 80/306 (26%), Positives = 138/306 (45%), Gaps = 18/306 (5%)
Query: 429 ESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGR 488
E ++ A++ N A W+N+G + A+ +F +A + P+ + A++N+G
Sbjct: 174 EEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN 233
Query: 489 TYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEA 548
K A +Y+ A SL +PNH V+ NLA + + ++ A
Sbjct: 234 VLKEARIFDRAVAAYLRALSL--------------SPNHAVVHGNLA-CVYYEQGLIDLA 278
Query: 549 DQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHI 608
YR+AI ++P F AY + L + +A++ Y AL L +AD NLA +
Sbjct: 279 IDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKR 338
Query: 609 ELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDA 668
E EA++ + +ALE+ P+ A N A V+Q+ G+++ EA I P A
Sbjct: 339 EQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQ---EALMHYKEAIRISPTFA 395
Query: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728
+ Y N+G + + A +AI++ F A NLA ++ + +A+
Sbjct: 396 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 455
Query: 729 LRYYPD 734
L+ PD
Sbjct: 456 LKLKPD 461
Score = 88.2 bits (217), Expect = 3e-17
Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 24/286 (8%)
Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
F A+ ++ N + N+G+ L+ + F+RA+ +L+A + P+ H N+ Y
Sbjct: 214 FEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQG 273
Query: 495 RTKEAEESYMMAKSLMPQIIPGK--------------------KYAARIAPNHLNVYINL 534
A ++Y A L P A R+ P H + NL
Sbjct: 274 LIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNL 333
Query: 535 ANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDR 594
AN I+ + +EEA +LYR+A+ + P+F A+ + +L + K +A Y +A+ +
Sbjct: 334 AN-IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP 392
Query: 595 NNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEAR 654
AD + N+ E+++ AL+ + RA+++NP A N A + ++SG + PEA
Sbjct: 393 TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI---PEAI 449
Query: 655 KRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQAD 700
+ + +P + Y NL + + MKK + + AD
Sbjct: 450 ASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD 495
Score = 59.3 bits (142), Expect = 2e-08
Identities = 71/304 (23%), Positives = 130/304 (42%), Gaps = 20/304 (6%)
Query: 522 RIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLK 581
R P++ V + L++ I RL+ + AI P +AY + G + + + +
Sbjct: 49 RQEPDNTGVLLLLSS-IHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE 107
Query: 582 AKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
A E Y AL L + D + NLA + + A++ + AL+ NP + ++
Sbjct: 108 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL 167
Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWM-----KKAIK 696
+ G ++ EA+ L I +P A + NLG + + + EIW+ +KA+
Sbjct: 168 KALGRLE---EAKACYLKAIETQPNFAVAWSNLGCVF-----NAQGEIWLAIHHFEKAVT 219
Query: 697 LQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDI--LMNQKKDIL 754
L +F A NL + + +A+ L P+H ++ G++ + ++ I
Sbjct: 220 LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH---AVVHGNLACVYYEQGLID 276
Query: 755 GAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP-HEEYIQRHLNI 813
A + R +E+ P NL E+ + +AE C L L P H + + NI
Sbjct: 277 LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANI 336
Query: 814 VRDK 817
R++
Sbjct: 337 KREQ 340
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 72.8 bits (177), Expect = 1e-12
Identities = 95/431 (22%), Positives = 173/431 (40%), Gaps = 33/431 (7%)
Query: 459 EKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKK 518
E N + +L+ F + P V R+ L + K A E Y A L +
Sbjct: 80 EGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKL-------NQ 132
Query: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
I+ N YI L +A DQL+ R D YI G++ L
Sbjct: 133 KDWEISHNLGVCYIYLKQFNKAQ-------DQLHNALNLNRHDL--TYIMLGKIHLLEGD 183
Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638
KA E Y KA+E N +L L +++++L +A ++ AL +P + A+ +
Sbjct: 184 LDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAG 243
Query: 639 IVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQ 698
+MQ G+ + + + + E P N N+GM KK A +K+A L
Sbjct: 244 SMMQTHGDFDVALTKYRVVACAVPESPPLWN---NIGMCFFGKKKYVAAISCLKRANYLA 300
Query: 699 ADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKK 758
L+NL L++ + A L + + P + L + + + +DI AK+
Sbjct: 301 PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQP-KMGELYMLLAVALTNLEDIENAKR 359
Query: 759 CFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKI 818
+ + +D N N V+ + + + + ALA ++E +++ +++++D
Sbjct: 360 AYAEAVHLDKCNPLVNLNYAVLLYNQGE---------KKNALAQYQE-MEKKVSLLKDNS 409
Query: 819 S---SSSFIEPIFPTSKISSVEGKKIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLG 875
S S +E V + T+ VK+ + + + T K + + SN+ LG
Sbjct: 410 SLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQQPLGSNQALG 469
Query: 876 KNGDEETPHKT 886
+ ++T
Sbjct: 470 QAMSSAAAYRT 480
Score = 55.8 bits (133), Expect = 2e-07
Identities = 64/279 (22%), Positives = 110/279 (39%), Gaps = 41/279 (14%)
Query: 537 LIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNN 596
LI E ++E+ +L++ + P L + K A E Y +A +L++ +
Sbjct: 75 LIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKD 134
Query: 597 ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKR 656
++ +NL + +I LK+ N+A + AL LN +H L
Sbjct: 135 WEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLT----------------------- 170
Query: 657 LLSYINEEPLDANGYFNLGML-AMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQT 715
Y LG + ++ D E++ KKA++ + L L LLY Q
Sbjct: 171 --------------YIMLGKIHLLEGDLDKAIEVY-KKAVEFSPENTELLTTLGLLYLQL 215
Query: 716 AKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKH 775
KA L L Y P + K ++ G +M D A + + P + +
Sbjct: 216 GIYQKAFEHLGNALTYDPTNYKAILAAGS-MMQTHGDFDVALTKYRVVACAVPESPPLWN 274
Query: 776 NLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIV 814
N+ + +F +K + A CL LAP + I +L +V
Sbjct: 275 NIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLV 313
Score = 32.0 bits (71), Expect = 2.7
Identities = 34/167 (20%), Positives = 68/167 (40%), Gaps = 18/167 (10%)
Query: 448 LWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAK 507
LWNN+G +K + A+ +A ++ P D N+G + + + A A
Sbjct: 272 LWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAI 331
Query: 508 SLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYI 567
+ P++ G+ Y + + + L NL +E A + Y +A+ + +
Sbjct: 332 NFQPKM--GELY--------MLLAVALTNL-----EDIENAKRAYAEAVHLDKCNPLVNL 376
Query: 568 SRGELLLKMNKPLKAKEAYL---KALELDRNNADLWYNLAIVHIELK 611
+ LL + A Y K + L ++N+ L ++ +V + K
Sbjct: 377 NYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEFDSEMVEMAQK 423
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 58.5 bits (140), Expect = 3e-08
Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%)
Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
F A +++ N L + FE A+ +F A + P + A++ G +Y
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352
Query: 495 R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551
TK+A++ ++ A I P ++ I+ ++A + + ++A
Sbjct: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397
Query: 552 YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611
+ AI P AY R + L+M A + A+++ A+ N ++H +
Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456
Query: 612 EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
A+K++ A+ LNPK+ LA Y
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479
Query: 672 FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731
FN G + ++ ++A + KA+K + L N A I +L+
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525
Query: 732 YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791
Y + AK+ F ++E P N Y+ K AE
Sbjct: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564
Query: 792 RCLLETLALAPHEEYIQRHLNIVRDKI 818
L + L+L P++ + VR KI
Sbjct: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591
Score = 55.5 bits (132), Expect = 2e-07
Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%)
Query: 402 FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457
FK+ + I + L H+ HR ++E F ALK+N + G++
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352
Query: 458 NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512
+++ ++A K FL+A H+ P I A ++ G + + ++A + +A P+
Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412
Query: 513 -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559
+ G +AA N ++ +I + A + Y+ AI++
Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472
Query: 560 PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619
P + AY + G + + +A + + KAL+ D N + N AI + LK+ EA ++
Sbjct: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532
Query: 620 FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
F +E P FN A + +L E + LS +P DA Y
Sbjct: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581
Score = 43.9 bits (102), Expect = 7e-04
Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%)
Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
+++RG + +++ + A E + +A + R N L + A+ H + E EA+ F AL+
Sbjct: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332
Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
+NP A E G + +A+K L ++ P + G K
Sbjct: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392
Query: 686 EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743
+A W I + D ++ A A++ Q A+ + ++ + L +G
Sbjct: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449
Query: 744 DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801
I M K++ A K ++ + ++P N +YF + +A + L
Sbjct: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
Query: 802 PHEEYI 807
P EY+
Sbjct: 1507 PENEYV 1512
Score = 39.3 bits (90), Expect = 0.017
Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%)
Query: 437 SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496
+A+K++ A+ N G E + + A+K + A + P A+ N G Y + +
Sbjct: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492
Query: 497 KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554
+A + + A P+ N Y+ L N N + EEA + +
Sbjct: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535
Query: 555 AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614
I P + Y +R + + A+E KAL L N+A ++ A V ++
Sbjct: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595
Query: 615 EALKNFNRALEL 626
EA+ ++N+AL+L
Sbjct: 1596 EAMADYNQALDL 1607
Score = 32.3 bits (72), Expect = 2.1
Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%)
Query: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
Y + N+ Y++ A + R + + A Y QAI P Y RGE+ NK
Sbjct: 976 YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034
Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638
L A + + K + D D + + E + A+++F L ++ ++ A
Sbjct: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093
Query: 639 IVMQ 642
++M+
Sbjct: 1094 LMMK 1097
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 58.5 bits (140), Expect = 3e-08
Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%)
Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
F A +++ N L + FE A+ +F A + P + A++ G +Y
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352
Query: 495 R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551
TK+A++ ++ A I P ++ I+ ++A + + ++A
Sbjct: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397
Query: 552 YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611
+ AI P AY R + L+M A + A+++ A+ N ++H +
Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456
Query: 612 EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
A+K++ A+ LNPK+ LA Y
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479
Query: 672 FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731
FN G + ++ ++A + KA+K + L N A I +L+
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525
Query: 732 YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791
Y + AK+ F ++E P N Y+ K AE
Sbjct: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564
Query: 792 RCLLETLALAPHEEYIQRHLNIVRDKI 818
L + L+L P++ + VR KI
Sbjct: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591
Score = 55.5 bits (132), Expect = 2e-07
Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%)
Query: 402 FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457
FK+ + I + L H+ HR ++E F ALK+N + G++
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352
Query: 458 NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512
+++ ++A K FL+A H+ P I A ++ G + + ++A + +A P+
Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412
Query: 513 -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559
+ G +AA N ++ +I + A + Y+ AI++
Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472
Query: 560 PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619
P + AY + G + + +A + + KAL+ D N + N AI + LK+ EA ++
Sbjct: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532
Query: 620 FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
F +E P FN A + +L E + LS +P DA Y
Sbjct: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581
Score = 43.9 bits (102), Expect = 7e-04
Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%)
Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
+++RG + +++ + A E + +A + R N L + A+ H + E EA+ F AL+
Sbjct: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332
Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
+NP A E G + +A+K L ++ P + G K
Sbjct: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392
Query: 686 EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743
+A W I + D ++ A A++ Q A+ + ++ + L +G
Sbjct: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449
Query: 744 DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801
I M K++ A K ++ + ++P N +YF + +A + L
Sbjct: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
Query: 802 PHEEYI 807
P EY+
Sbjct: 1507 PENEYV 1512
Score = 39.3 bits (90), Expect = 0.017
Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%)
Query: 437 SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496
+A+K++ A+ N G E + + A+K + A + P A+ N G Y + +
Sbjct: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492
Query: 497 KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554
+A + + A P+ N Y+ L N N + EEA + +
Sbjct: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535
Query: 555 AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614
I P + Y +R + + A+E KAL L N+A ++ A V ++
Sbjct: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595
Query: 615 EALKNFNRALEL 626
EA+ ++N+AL+L
Sbjct: 1596 EAMADYNQALDL 1607
Score = 32.3 bits (72), Expect = 2.1
Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%)
Query: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
Y + N+ Y++ A + R + + A Y QAI P Y RGE+ NK
Sbjct: 976 YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034
Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638
L A + + K + D D + + E + A+++F L ++ ++ A
Sbjct: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093
Query: 639 IVMQ 642
++M+
Sbjct: 1094 LMMK 1097
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 58.5 bits (140), Expect = 3e-08
Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%)
Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
F A +++ N L + FE A+ +F A + P + A++ G +Y
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352
Query: 495 R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551
TK+A++ ++ A I P ++ I+ ++A + + ++A
Sbjct: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397
Query: 552 YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611
+ AI P AY R + L+M A + A+++ A+ N ++H +
Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456
Query: 612 EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
A+K++ A+ LNPK+ LA Y
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479
Query: 672 FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731
FN G + ++ ++A + KA+K + L N A I +L+
Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525
Query: 732 YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791
Y + AK+ F ++E P N Y+ K AE
Sbjct: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564
Query: 792 RCLLETLALAPHEEYIQRHLNIVRDKI 818
L + L+L P++ + VR KI
Sbjct: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591
Score = 55.5 bits (132), Expect = 2e-07
Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%)
Query: 402 FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457
FK+ + I + L H+ HR ++E F ALK+N + G++
Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352
Query: 458 NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512
+++ ++A K FL+A H+ P I A ++ G + + ++A + +A P+
Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412
Query: 513 -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559
+ G +AA N ++ +I + A + Y+ AI++
Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472
Query: 560 PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619
P + AY + G + + +A + + KAL+ D N + N AI + LK+ EA ++
Sbjct: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532
Query: 620 FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671
F +E P FN A + +L E + LS +P DA Y
Sbjct: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581
Score = 43.9 bits (102), Expect = 7e-04
Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%)
Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
+++RG + +++ + A E + +A + R N L + A+ H + E EA+ F AL+
Sbjct: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332
Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
+NP A E G + +A+K L ++ P + G K
Sbjct: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392
Query: 686 EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743
+A W I + D ++ A A++ Q A+ + ++ + L +G
Sbjct: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449
Query: 744 DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801
I M K++ A K ++ + ++P N +YF + +A + L
Sbjct: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
Query: 802 PHEEYI 807
P EY+
Sbjct: 1507 PENEYV 1512
Score = 39.3 bits (90), Expect = 0.017
Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%)
Query: 437 SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496
+A+K++ A+ N G E + + A+K + A + P A+ N G Y + +
Sbjct: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492
Query: 497 KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554
+A + + A P+ N Y+ L N N + EEA + +
Sbjct: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535
Query: 555 AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614
I P + Y +R + + A+E KAL L N+A ++ A V ++
Sbjct: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595
Query: 615 EALKNFNRALEL 626
EA+ ++N+AL+L
Sbjct: 1596 EAMADYNQALDL 1607
Score = 32.3 bits (72), Expect = 2.1
Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%)
Query: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
Y + N+ Y++ A + R + + A Y QAI P Y RGE+ NK
Sbjct: 976 YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034
Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638
L A + + K + D D + + E + A+++F L ++ ++ A
Sbjct: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093
Query: 639 IVMQ 642
++M+
Sbjct: 1094 LMMK 1097
>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
A [Homo sapiens]
Length = 608
Score = 57.0 bits (136), Expect = 8e-08
Identities = 49/209 (23%), Positives = 91/209 (43%), Gaps = 14/209 (6%)
Query: 518 KYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMN 577
KY A Y+ + N A + L++ L + +R + A I RG + ++
Sbjct: 326 KYMAEALLLRATFYLLIGNA-NAAKPDLDKVISLKEANVKLRAN---ALIKRGSMYMQQQ 381
Query: 578 KPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKL----- 632
+PL + + + A ++D NAD++++ + I L + EA+ +F+ + L P+ L
Sbjct: 382 QPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQK 441
Query: 633 --ALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIW 690
AL+ A S +++ A K I + P A GY D ++ +A+
Sbjct: 442 CFALYRQAYTGNNSSQIQ---AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEM 498
Query: 691 MKKAIKLQADFRSALFNLALLYSQTAKEL 719
K I L+ D + + LL Q ++L
Sbjct: 499 YDKCIDLEPDNATTYVHKGLLQLQWKQDL 527
Score = 42.0 bits (97), Expect = 0.003
Identities = 24/88 (27%), Positives = 47/88 (53%), Gaps = 3/88 (3%)
Query: 541 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPL-KAKEAYLKALELDRNNADL 599
++ + +AD++Y + I + PD Y+ +G L L+ + L + E KA+E+D N D
Sbjct: 488 DQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEID-NKCDF 546
Query: 600 WYN-LAIVHIELKEPNEALKNFNRALEL 626
Y + + ++ +A+ FN+A+ L
Sbjct: 547 AYETMGTIEVQRGNMEKAIDMFNKAINL 574
Score = 37.4 bits (85), Expect = 0.064
Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 561 DFKQAYISRGELLLKMNKPLKAKEAYLKALEL--DRNNADL---WYNLAIVHIELKEPNE 615
D QA ++G K K +A + Y +A+ L N DL + N A +L++ E
Sbjct: 112 DRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKE 171
Query: 616 ALKNFNRALELNPKHKLALFNSA 638
++ +A+ELNPK+ ALF A
Sbjct: 172 VAQDCTKAVELNPKYVKALFRRA 194
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 55.5 bits (132), Expect = 2e-07
Identities = 41/156 (26%), Positives = 77/156 (49%), Gaps = 4/156 (2%)
Query: 520 AARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKP 579
A ++ PN+ Y L + E L++A +R AI + P A+ G + K K
Sbjct: 599 AIQVDPNYAYAYTLLGHEFVLTEE-LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKF 657
Query: 580 LKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
A+ + KAL+++ ++ L ++ +V LK+ +AL N+A+ ++PK+ L F+ A
Sbjct: 658 SLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRAS 717
Query: 640 VMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLG 675
V+ + + K + + L + +E L YF +G
Sbjct: 718 VLFANEKYKSALQELEELKQIVPKESL---VYFLIG 750
Score = 53.9 bits (128), Expect = 7e-07
Identities = 57/275 (20%), Positives = 115/275 (41%), Gaps = 28/275 (10%)
Query: 428 WESEYTLFMSALK-----VNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGA 482
W + + +S L ++KN+ + W G+ ++ + A+K+F +A V P+ A
Sbjct: 550 WHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYA 609
Query: 483 HMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE 542
+ +G + T+E +++ ++ A R+ P H N + L +I +
Sbjct: 610 YTLLGHEFV---LTEELDKALACFRN-----------AIRVNPRHYNAWYGL-GMIYYKQ 654
Query: 543 SRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYN 602
+ A+ +++A+ + P G + + K KA + KA+ +D N ++
Sbjct: 655 EKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFH 714
Query: 603 LAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYIN 662
A V ++ AL+ ++ PK L F V ++ G+ L L+++
Sbjct: 715 RASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHL------ALMNFSW 768
Query: 663 EEPLDANGYFNLGMLAMDDK--KDNEAEIWMKKAI 695
LD G N A+D + D+E I ++ I
Sbjct: 769 AMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQI 803
Score = 42.0 bits (97), Expect = 0.003
Identities = 32/141 (22%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 591 ELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLA--LFNSAIVMQESGEVK 648
++D+N+ + W +E + A+K F RA++++P + A L V+ E +
Sbjct: 567 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD-- 624
Query: 649 LRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708
+A + I P N ++ LGM+ +K + AE+ +KA+ + L ++
Sbjct: 625 ---KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 681
Query: 709 ALLYSQTAKELKALPILEELL 729
++ K KAL L + +
Sbjct: 682 GVVQHALKKSEKALDTLNKAI 702
Score = 40.4 bits (93), Expect = 0.008
Identities = 44/227 (19%), Positives = 86/227 (37%), Gaps = 38/227 (16%)
Query: 548 ADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVH 607
A + +++AI + P++ AY G + + KA + A+ ++ + + WY L +++
Sbjct: 592 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 651
Query: 608 IELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLD 667
+ ++ + A +F +AL++NP+ + L + +V
Sbjct: 652 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHAL----------------------- 688
Query: 668 ANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEE 727
KK +A + KAI + F+ A + K AL LEE
Sbjct: 689 --------------KKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEE 734
Query: 728 LLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGK 774
L + P L G + + L A F +++DP +
Sbjct: 735 LKQIVPKESLVYFLIGKVYKKLGQTHL-ALMNFSWAMDLDPKGANNQ 780
Score = 32.3 bits (72), Expect = 2.1
Identities = 18/102 (17%), Positives = 47/102 (46%), Gaps = 3/102 (2%)
Query: 721 ALPILEELLRYYPDHIKGLILKG-DILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCV 779
A+ + ++ P++ L G + ++ ++ D A CF + ++P + + L +
Sbjct: 592 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD--KALACFRNAIRVNPRHYNAWYGLGM 649
Query: 780 VYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSS 821
+Y++++ AE + L + P + H+ +V+ + S
Sbjct: 650 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 691
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 55.5 bits (132), Expect = 2e-07
Identities = 41/156 (26%), Positives = 77/156 (49%), Gaps = 4/156 (2%)
Query: 520 AARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKP 579
A ++ PN+ Y L + E L++A +R AI + P A+ G + K K
Sbjct: 593 AIQVDPNYAYAYTLLGHEFVLTEE-LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKF 651
Query: 580 LKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
A+ + KAL+++ ++ L ++ +V LK+ +AL N+A+ ++PK+ L F+ A
Sbjct: 652 SLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRAS 711
Query: 640 VMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLG 675
V+ + + K + + L + +E L YF +G
Sbjct: 712 VLFANEKYKSALQELEELKQIVPKESL---VYFLIG 744
Score = 53.9 bits (128), Expect = 7e-07
Identities = 57/275 (20%), Positives = 115/275 (41%), Gaps = 28/275 (10%)
Query: 428 WESEYTLFMSALK-----VNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGA 482
W + + +S L ++KN+ + W G+ ++ + A+K+F +A V P+ A
Sbjct: 544 WHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYA 603
Query: 483 HMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE 542
+ +G + T+E +++ ++ A R+ P H N + L +I +
Sbjct: 604 YTLLGHEFV---LTEELDKALACFRN-----------AIRVNPRHYNAWYGL-GMIYYKQ 648
Query: 543 SRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYN 602
+ A+ +++A+ + P G + + K KA + KA+ +D N ++
Sbjct: 649 EKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFH 708
Query: 603 LAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYIN 662
A V ++ AL+ ++ PK L F V ++ G+ L L+++
Sbjct: 709 RASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHL------ALMNFSW 762
Query: 663 EEPLDANGYFNLGMLAMDDK--KDNEAEIWMKKAI 695
LD G N A+D + D+E I ++ I
Sbjct: 763 AMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQI 797
Score = 42.0 bits (97), Expect = 0.003
Identities = 32/141 (22%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 591 ELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLA--LFNSAIVMQESGEVK 648
++D+N+ + W +E + A+K F RA++++P + A L V+ E +
Sbjct: 561 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD-- 618
Query: 649 LRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708
+A + I P N ++ LGM+ +K + AE+ +KA+ + L ++
Sbjct: 619 ---KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675
Query: 709 ALLYSQTAKELKALPILEELL 729
++ K KAL L + +
Sbjct: 676 GVVQHALKKSEKALDTLNKAI 696
Score = 40.4 bits (93), Expect = 0.008
Identities = 44/227 (19%), Positives = 86/227 (37%), Gaps = 38/227 (16%)
Query: 548 ADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVH 607
A + +++AI + P++ AY G + + KA + A+ ++ + + WY L +++
Sbjct: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 645
Query: 608 IELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLD 667
+ ++ + A +F +AL++NP+ + L + +V
Sbjct: 646 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHAL----------------------- 682
Query: 668 ANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEE 727
KK +A + KAI + F+ A + K AL LEE
Sbjct: 683 --------------KKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEE 728
Query: 728 LLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGK 774
L + P L G + + L A F +++DP +
Sbjct: 729 LKQIVPKESLVYFLIGKVYKKLGQTHL-ALMNFSWAMDLDPKGANNQ 774
Score = 32.3 bits (72), Expect = 2.1
Identities = 18/102 (17%), Positives = 47/102 (46%), Gaps = 3/102 (2%)
Query: 721 ALPILEELLRYYPDHIKGLILKG-DILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCV 779
A+ + ++ P++ L G + ++ ++ D A CF + ++P + + L +
Sbjct: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD--KALACFRNAIRVNPRHYNAWYGLGM 643
Query: 780 VYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSS 821
+Y++++ AE + L + P + H+ +V+ + S
Sbjct: 644 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 685
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 52.0 bits (123), Expect = 3e-06
Identities = 103/498 (20%), Positives = 188/498 (37%), Gaps = 80/498 (16%)
Query: 444 NNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHM------NVGRTYKNLNRTK 497
++ + W + LE + + + AL + AT + + + A + NVG + L
Sbjct: 410 DDVEAWIELAQILE-QTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLG 468
Query: 498 EAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLA------NLIRANESRLE--EAD 549
EA++ ++ + A+ H Y N NL R E+ E EA+
Sbjct: 469 EAKKYFLASLD-----------RAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAE 517
Query: 550 QLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIE 609
+LY+ + P++ Y+ G + +A + + +AL++++++ D W + +H+
Sbjct: 518 KLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLA 577
Query: 610 LKEPNEALKNFNRAL-----ELNPKHKLALFNSAIVMQESGEVKLRPEARKR-----LLS 659
+E K F R L + + LAL N + +Q + E KR L
Sbjct: 578 KQEWGPGQKKFERILKQPSTQSDTYSMLALGN--VWLQTLHQPTRDREKEKRHQDRALAI 635
Query: 660 YINEEPLDANGYF---NLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTA 716
Y DA + +G + EA + + AD NLA +Y +
Sbjct: 636 YKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQK 695
Query: 717 KELKALPILEELLRYYPDH--------IKGLILKGDILMNQKKDILGAKKCFERILEMDP 768
+ + A+ + E LR + H + + K L K+ +L A+ + P
Sbjct: 696 QYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKAR-------HVAP 748
Query: 769 SNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIF 828
S+ N+ +V L T L + ++ LN V++ + +
Sbjct: 749 SDTVLMFNVALVLQR-----------LATSVLKDEKSNLKEVLNAVKELELAHRYF---- 793
Query: 829 PTSKISSVEGKKIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTK 888
S +S V G K+ + T+ + SD SQ++ + + DEE K
Sbjct: 794 --SYLSKV-GDKMRFDLA------LAATEARQCSDLLSQAQYHVARARKQDEEERELRAK 844
Query: 889 DIKEIEKKRVAALKRLEE 906
+E E R LK EE
Sbjct: 845 QEQEKELLRQKLLKEQEE 862
Score = 48.1 bits (113), Expect = 4e-05
Identities = 56/274 (20%), Positives = 114/274 (41%), Gaps = 15/274 (5%)
Query: 524 APNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFK-QAYISRGELLLKMNKPLKA 582
+PN++ + A I N+ A Y++A+ P + + G +K+NK KA
Sbjct: 159 SPNNIPALLGKA-CISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKA 217
Query: 583 KEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN----FNRALELNPKHKLALFNSA 638
+ A+ +ALEL+ LA++ + KE +++KN +RA ++P + + L + A
Sbjct: 218 RLAFSRALELNSKCVGALVGLAVLELNNKEA-DSIKNGVQLLSRAYTIDPSNPMVLNHLA 276
Query: 639 IVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLG-MLAMDDKKDNEAEIWMKKAIKL 697
+ E + A + L + + D + + +
Sbjct: 277 NHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFA 336
Query: 698 QADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILM----NQKKDI 753
+ F F L +Y + A E++L+ YP++ + + + G + +K+DI
Sbjct: 337 SSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDI 396
Query: 754 LGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDL 787
AK +++ E P +V+ L + E+ D+
Sbjct: 397 --AKGHLKKVTEQYPDDVEAWIELAQI-LEQTDI 427
Score = 43.9 bits (102), Expect = 7e-04
Identities = 55/270 (20%), Positives = 114/270 (42%), Gaps = 23/270 (8%)
Query: 434 LFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNL 493
L+ + L+ + N + +G ++ NF A +F +A + D A +G +
Sbjct: 519 LYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAK 578
Query: 494 NRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEE-ADQLY 552
++ + + L Y+ N ++ R E R ++ A +Y
Sbjct: 579 QEWGPGQKKF--ERILKQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIY 636
Query: 553 RQAISMRPDFKQAYISRGELLLKMNKPL--KAKEAYLKALELDRNNADLWYNLAIVHIEL 610
+Q + R D K Y + G + +K +A++ + + E + +D+W NLA +++E
Sbjct: 637 KQVL--RNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQ 694
Query: 611 KEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEV----KLRPEARKRLLSYINEEPL 666
K+ A++ + L KH+ N+ +V+ + + KL+ E ++ LL + P
Sbjct: 695 KQYISAVQMYENCLRKFYKHQ----NTEVVLYLARALFKCGKLQ-ECKQTLLKARHVAPS 749
Query: 667 DANGYFNLGML-------AMDDKKDNEAEI 689
D FN+ ++ + D+K N E+
Sbjct: 750 DTVLMFNVALVLQRLATSVLKDEKSNLKEV 779
>gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo
sapiens]
Length = 1347
Score = 51.2 bits (121), Expect = 4e-06
Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 26/215 (12%)
Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQ- 476
F N D++S F AL +NA++ ++ H E ++ + A + + Q +
Sbjct: 174 FKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEN 233
Query: 477 -PDDIGAHM--NVGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHL 528
P + A + +G + N++ TKE+ + KSL PN
Sbjct: 234 LPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD------------PNSG 281
Query: 529 NVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLK 588
+ L ++ ++++A YRQ+I + S G L + N+P+ A +AY+
Sbjct: 282 QSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340
Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623
A++LD +A W +L ++ +P +A+K + A
Sbjct: 341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
>gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo
sapiens]
Length = 1079
Score = 51.2 bits (121), Expect = 4e-06
Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 26/215 (12%)
Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQ- 476
F N D++S F AL +NA++ ++ H E ++ + A + + Q +
Sbjct: 174 FKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEN 233
Query: 477 -PDDIGAHM--NVGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHL 528
P + A + +G + N++ TKE+ + KSL PN
Sbjct: 234 LPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD------------PNSG 281
Query: 529 NVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLK 588
+ L ++ ++++A YRQ+I + S G L + N+P+ A +AY+
Sbjct: 282 QSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340
Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623
A++LD +A W +L ++ +P +A+K + A
Sbjct: 341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
>gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo
sapiens]
Length = 1240
Score = 51.2 bits (121), Expect = 4e-06
Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 26/215 (12%)
Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQ- 476
F N D++S F AL +NA++ ++ H E ++ + A + + Q +
Sbjct: 174 FKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEN 233
Query: 477 -PDDIGAHM--NVGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHL 528
P + A + +G + N++ TKE+ + KSL PN
Sbjct: 234 LPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD------------PNSG 281
Query: 529 NVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLK 588
+ L ++ ++++A YRQ+I + S G L + N+P+ A +AY+
Sbjct: 282 QSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340
Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623
A++LD +A W +L ++ +P +A+K + A
Sbjct: 341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
>gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X
chromosome [Homo sapiens]
Length = 1401
Score = 50.4 bits (119), Expect = 7e-06
Identities = 49/217 (22%), Positives = 95/217 (43%), Gaps = 30/217 (13%)
Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQP 477
F N D+ES F AL +NA++ ++ H E ++ + A + + Q +Q
Sbjct: 177 FKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQL--LQT 234
Query: 478 DDIGAHMN------VGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPN 526
+++ A + +G + ++ TKE+ + KSL PN
Sbjct: 235 ENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEAD------------PN 282
Query: 527 HLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAY 586
+ L ++ ++++A YRQ+I + S G L + N+P+ A +AY
Sbjct: 283 SGQSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAY 341
Query: 587 LKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623
+ A++LD +A W +L ++ +P +A+K + A
Sbjct: 342 ICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 378
>gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens]
Length = 626
Score = 50.1 bits (118), Expect = 1e-05
Identities = 27/88 (30%), Positives = 45/88 (51%)
Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
FH + ++ F +AL V + LWN +G L N E A++ + +A +QP I
Sbjct: 484 FHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIR 543
Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
+ N+G + NL +EA +++ A SL
Sbjct: 544 SRYNLGISCINLGAYREAVSNFLTALSL 571
Score = 45.8 bits (107), Expect = 2e-04
Identities = 50/230 (21%), Positives = 92/230 (40%), Gaps = 32/230 (13%)
Query: 434 LFM-SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKN 492
LFM +A+ + +A+ W +G +N + A+ + +QP+++ A M + +Y N
Sbjct: 347 LFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTN 406
Query: 493 LNRTKEAEES---YMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEAD 549
++A ++ ++ ++ KK + + ++ + L E LE A
Sbjct: 407 TGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAH 466
Query: 550 Q----------------------------LYRQAISMRPDFKQAYISRGELLLKMNKPLK 581
Q + A+++RP+ + G L ++ +
Sbjct: 467 QNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEE 526
Query: 582 AKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
A EAY +ALE+ YNL I I L EA+ NF AL L K +
Sbjct: 527 AVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSR 576
Score = 34.3 bits (77), Expect = 0.54
Identities = 18/75 (24%), Positives = 40/75 (53%)
Query: 661 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK 720
I ++P DA + LG+ +++ + A + +++ ++LQ + AL LA+ Y+ T +
Sbjct: 353 ILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQD 412
Query: 721 ALPILEELLRYYPDH 735
A L+ ++ P +
Sbjct: 413 ACDALKNWIKQNPKY 427
Score = 31.6 bits (70), Expect = 3.5
Identities = 34/175 (19%), Positives = 66/175 (37%), Gaps = 23/175 (13%)
Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
+W + + +K K + L + + + E + +L+A H D I +
Sbjct: 419 NWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQT 478
Query: 487 G-----RTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRAN 541
G NR +A + A + P +++ L + AN
Sbjct: 479 GLGVLFHLSGEFNRAIDAFNA-----------------ALTVRPEDYSLWNRLGATL-AN 520
Query: 542 ESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNN 596
R EEA + Y +A+ ++P F ++ + G + + +A +L AL L R +
Sbjct: 521 GDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKS 575
Score = 31.2 bits (69), Expect = 4.6
Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 3/77 (3%)
Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVK 648
A+ D +A+ W L I E + A+ R LEL P + AL A+ +G
Sbjct: 352 AILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGH-- 409
Query: 649 LRPEARKRLLSYINEEP 665
+ +A L ++I + P
Sbjct: 410 -QQDACDALKNWIKQNP 425
>gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo
sapiens]
Length = 639
Score = 48.5 bits (114), Expect = 3e-05
Identities = 26/88 (29%), Positives = 46/88 (52%)
Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
F+ + +++ F +AL V N+ LWN +G L N E A+ + +A +QP I
Sbjct: 498 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 557
Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
+ N+G + NL +EA E ++ A ++
Sbjct: 558 SRYNLGISCINLGAHREAVEHFLEALNM 585
Score = 39.7 bits (91), Expect = 0.013
Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%)
Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
A R+ P ++ + + N S ++A + A+S+RP+ + G L N+
Sbjct: 478 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 537
Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
+A AY +ALEL YNL I I L EA+++F AL + K +
Sbjct: 538 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 590
Score = 36.2 bits (82), Expect = 0.14
Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%)
Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
D + LF +A++ + + + W +G + A+ + ++PD+ A M +
Sbjct: 350 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 409
Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540
++ N + ++A E+ P + P ++ A A + P+ L +L+
Sbjct: 410 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 463
Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
++S E +L+ A+ + P G L + KA + + AL + N+
Sbjct: 464 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 523
Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
LW L + EA+ + RALEL P + + +N I
Sbjct: 524 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 564
>gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo
sapiens]
Length = 639
Score = 48.5 bits (114), Expect = 3e-05
Identities = 26/88 (29%), Positives = 46/88 (52%)
Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
F+ + +++ F +AL V N+ LWN +G L N E A+ + +A +QP I
Sbjct: 498 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 557
Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
+ N+G + NL +EA E ++ A ++
Sbjct: 558 SRYNLGISCINLGAHREAVEHFLEALNM 585
Score = 39.7 bits (91), Expect = 0.013
Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%)
Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
A R+ P ++ + + N S ++A + A+S+RP+ + G L N+
Sbjct: 478 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 537
Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
+A AY +ALEL YNL I I L EA+++F AL + K +
Sbjct: 538 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 590
Score = 36.2 bits (82), Expect = 0.14
Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%)
Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
D + LF +A++ + + + W +G + A+ + ++PD+ A M +
Sbjct: 350 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 409
Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540
++ N + ++A E+ P + P ++ A A + P+ L +L+
Sbjct: 410 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 463
Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
++S E +L+ A+ + P G L + KA + + AL + N+
Sbjct: 464 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 523
Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
LW L + EA+ + RALEL P + + +N I
Sbjct: 524 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 564
>gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo
sapiens]
Length = 602
Score = 48.5 bits (114), Expect = 3e-05
Identities = 26/88 (29%), Positives = 46/88 (52%)
Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
F+ + +++ F +AL V N+ LWN +G L N E A+ + +A +QP I
Sbjct: 461 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 520
Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
+ N+G + NL +EA E ++ A ++
Sbjct: 521 SRYNLGISCINLGAHREAVEHFLEALNM 548
Score = 39.7 bits (91), Expect = 0.013
Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%)
Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
A R+ P ++ + + N S ++A + A+S+RP+ + G L N+
Sbjct: 441 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 500
Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
+A AY +ALEL YNL I I L EA+++F AL + K +
Sbjct: 501 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 553
Score = 36.2 bits (82), Expect = 0.14
Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%)
Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
D + LF +A++ + + + W +G + A+ + ++PD+ A M +
Sbjct: 313 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 372
Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540
++ N + ++A E+ P + P ++ A A + P+ L +L+
Sbjct: 373 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 426
Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
++S E +L+ A+ + P G L + KA + + AL + N+
Sbjct: 427 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 486
Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
LW L + EA+ + RALEL P + + +N I
Sbjct: 487 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 527
>gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo
sapiens]
Length = 654
Score = 48.5 bits (114), Expect = 3e-05
Identities = 26/88 (29%), Positives = 46/88 (52%)
Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
F+ + +++ F +AL V N+ LWN +G L N E A+ + +A +QP I
Sbjct: 513 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 572
Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
+ N+G + NL +EA E ++ A ++
Sbjct: 573 SRYNLGISCINLGAHREAVEHFLEALNM 600
Score = 39.7 bits (91), Expect = 0.013
Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%)
Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
A R+ P ++ + + N S ++A + A+S+RP+ + G L N+
Sbjct: 493 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 552
Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
+A AY +ALEL YNL I I L EA+++F AL + K +
Sbjct: 553 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 605
Score = 36.2 bits (82), Expect = 0.14
Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%)
Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
D + LF +A++ + + + W +G + A+ + ++PD+ A M +
Sbjct: 365 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 424
Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540
++ N + ++A E+ P + P ++ A A + P+ L +L+
Sbjct: 425 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 478
Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
++S E +L+ A+ + P G L + KA + + AL + N+
Sbjct: 479 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 538
Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
LW L + EA+ + RALEL P + + +N I
Sbjct: 539 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 579
>gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo
sapiens]
Length = 631
Score = 48.5 bits (114), Expect = 3e-05
Identities = 26/88 (29%), Positives = 46/88 (52%)
Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481
F+ + +++ F +AL V N+ LWN +G L N E A+ + +A +QP I
Sbjct: 490 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 549
Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509
+ N+G + NL +EA E ++ A ++
Sbjct: 550 SRYNLGISCINLGAHREAVEHFLEALNM 577
Score = 39.7 bits (91), Expect = 0.013
Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%)
Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578
A R+ P ++ + + N S ++A + A+S+RP+ + G L N+
Sbjct: 470 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 529
Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631
+A AY +ALEL YNL I I L EA+++F AL + K +
Sbjct: 530 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 582
Score = 36.2 bits (82), Expect = 0.14
Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%)
Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486
D + LF +A++ + + + W +G + A+ + ++PD+ A M +
Sbjct: 342 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 401
Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540
++ N + ++A E+ P + P ++ A A + P+ L +L+
Sbjct: 402 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 455
Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598
++S E +L+ A+ + P G L + KA + + AL + N+
Sbjct: 456 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 515
Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
LW L + EA+ + RALEL P + + +N I
Sbjct: 516 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 556
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 47.4 bits (111), Expect = 6e-05
Identities = 46/201 (22%), Positives = 82/201 (40%), Gaps = 24/201 (11%)
Query: 456 LENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIP 515
L + KN E AL + ++PD L R EA A L P
Sbjct: 192 LHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPS--- 248
Query: 516 GKKYAAR-----IAPNHLNVYINLANLIRANESR----------------LEEADQLYRQ 554
+ Y R I+ ++ + + + N+++ L+EA + +++
Sbjct: 249 ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKE 308
Query: 555 AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614
A+ + DF AY S G+ ++ A E++ KAL L++N+ ++
Sbjct: 309 ALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQ 368
Query: 615 EALKNFNRALELNPKHKLALF 635
EALKNF R L+L P +++ +
Sbjct: 369 EALKNFKRCLQLEPYNEVCQY 389
Score = 44.3 bits (103), Expect = 5e-04
Identities = 45/217 (20%), Positives = 93/217 (42%), Gaps = 39/217 (17%)
Query: 554 QAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEP 613
+ I++ PD + + R E+L + + +A KA++L + +A L+ + ++ ++
Sbjct: 207 RVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQL-QPSARLYRHRGTLYFISEDY 265
Query: 614 NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFN 673
A ++F ++LELN +A+ + +F+
Sbjct: 266 ATAHEDFQQSLELNKNQPIAMLYKGLT------------------------------FFH 295
Query: 674 LGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYP 733
G+L EA K+A+K + DF A +L Y + A ++ L
Sbjct: 296 RGLL-------KEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 348
Query: 734 DHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSN 770
+H++ L L+G +++ + A K F+R L+++P N
Sbjct: 349 NHVQTLQLRG-MMLYHHGSLQEALKNFKRCLQLEPYN 384
>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
sapiens]
Length = 515
Score = 47.0 bits (110), Expect = 8e-05
Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%)
Query: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524
AL F Q P ++ + R Y+ +N A E Y K ++ Q + A I
Sbjct: 277 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 333
Query: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584
NH + E A + YR+ + M Q + + G +
Sbjct: 334 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 381
Query: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
++ +AL L N AD+WYNL V + + + N A + F AL N H A N A++
Sbjct: 382 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 441
Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678
G V+ +AR L + + P +FN ++
Sbjct: 442 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 475
Score = 45.4 bits (106), Expect = 2e-04
Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%)
Query: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529
L H Q D + +G+ Y L +EAE+ + A +++ Y A+
Sbjct: 215 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 266
Query: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589
VY++L + A L++Q + P + +MN A E Y +
Sbjct: 267 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 318
Query: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649
L+ D + + + H +P AL+ + R L++ + N + + + +
Sbjct: 319 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 378
Query: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709
+ +R LS E A+ ++NLG +A+ N A + A+ + A NLA
Sbjct: 379 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 438
Query: 710 LLYSQTAKELKALPILE 726
+L + +A +L+
Sbjct: 439 VLEMRKGHVEQARALLQ 455
>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
sapiens]
Length = 475
Score = 47.0 bits (110), Expect = 8e-05
Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%)
Query: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524
AL F Q P ++ + R Y+ +N A E Y K ++ Q + A I
Sbjct: 237 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 293
Query: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584
NH + E A + YR+ + M Q + + G +
Sbjct: 294 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 341
Query: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
++ +AL L N AD+WYNL V + + + N A + F AL N H A N A++
Sbjct: 342 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 401
Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678
G V+ +AR L + + P +FN ++
Sbjct: 402 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 435
Score = 45.4 bits (106), Expect = 2e-04
Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%)
Query: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529
L H Q D + +G+ Y L +EAE+ + A +++ Y A+
Sbjct: 175 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 226
Query: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589
VY++L + A L++Q + P + +MN A E Y +
Sbjct: 227 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 278
Query: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649
L+ D + + + H +P AL+ + R L++ + N + + + +
Sbjct: 279 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 338
Query: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709
+ +R LS E A+ ++NLG +A+ N A + A+ + A NLA
Sbjct: 339 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 398
Query: 710 LLYSQTAKELKALPILE 726
+L + +A +L+
Sbjct: 399 VLEMRKGHVEQARALLQ 415
>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
sapiens]
Length = 505
Score = 47.0 bits (110), Expect = 8e-05
Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%)
Query: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524
AL F Q P ++ + R Y+ +N A E Y K ++ Q + A I
Sbjct: 267 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 323
Query: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584
NH + E A + YR+ + M Q + + G +
Sbjct: 324 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 371
Query: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641
++ +AL L N AD+WYNL V + + + N A + F AL N H A N A++
Sbjct: 372 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 431
Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678
G V+ +AR L + + P +FN ++
Sbjct: 432 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 465
Score = 45.4 bits (106), Expect = 2e-04
Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%)
Query: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529
L H Q D + +G+ Y L +EAE+ + A +++ Y A+
Sbjct: 205 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 256
Query: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589
VY++L + A L++Q + P + +MN A E Y +
Sbjct: 257 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 308
Query: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649
L+ D + + + H +P AL+ + R L++ + N + + + +
Sbjct: 309 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 368
Query: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709
+ +R LS E A+ ++NLG +A+ N A + A+ + A NLA
Sbjct: 369 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 428
Query: 710 LLYSQTAKELKALPILE 726
+L + +A +L+
Sbjct: 429 VLEMRKGHVEQARALLQ 445
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 47.0 bits (110), Expect = 8e-05
Identities = 27/91 (29%), Positives = 49/91 (53%)
Query: 545 LEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLA 604
L+EA + +++A+ + DF AY S G+ ++ A E++ KAL L++N+
Sbjct: 246 LKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRG 305
Query: 605 IVHIELKEPNEALKNFNRALELNPKHKLALF 635
++ EALKNF R L+L P +++ +
Sbjct: 306 MMLYHHGSLQEALKNFKRCLQLEPYNEVCQY 336
Score = 38.9 bits (89), Expect = 0.022
Identities = 49/222 (22%), Positives = 94/222 (42%), Gaps = 31/222 (13%)
Query: 571 ELLLKMNKPLKAKEAYLKALELDRNNADL----------WYNLAIVH----IELKEP--- 613
E +L K + ++ + A + D N +L Y+ AI H +++ P
Sbjct: 119 EKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGR 178
Query: 614 -NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPL----DA 668
NEA+ + +A++L P +L + S + E ++ L +P+
Sbjct: 179 INEAVNDLTKAIQLQPSARLYRHRGTLYFI-SEDYATAHEDFQQSLELNKNQPIAMLYKG 237
Query: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728
+F+ G+L EA K+A+K + DF A +L Y + A ++
Sbjct: 238 LTFFHRGLL-------KEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290
Query: 729 LRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSN 770
L +H++ L L+G +++ + A K F+R L+++P N
Sbjct: 291 LLLNQNHVQTLQLRG-MMLYHHGSLQEALKNFKRCLQLEPYN 331
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,403,484
Number of Sequences: 37866
Number of extensions: 1338340
Number of successful extensions: 4684
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 3899
Number of HSP's gapped (non-prelim): 565
length of query: 914
length of database: 18,247,518
effective HSP length: 111
effective length of query: 803
effective length of database: 14,044,392
effective search space: 11277646776
effective search space used: 11277646776
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.