BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|224809432 transmembrane and tetratricopeptide repeat containing 3 [Homo sapiens] (914 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|224809432 transmembrane and tetratricopeptide repeat containi... 1813 0.0 gi|118766328 transmembrane and tetratricopeptide repeat containi... 392 e-108 gi|118766330 transmembrane and tetratricopeptide repeat containi... 392 e-108 gi|22749211 transmembrane and tetratricopeptide repeat containin... 325 9e-89 gi|83415184 transmembrane and tetratricopeptide repeat containin... 215 2e-55 gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 108 3e-23 gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 108 3e-23 gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 73 1e-12 gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 59 3e-08 gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 59 3e-08 gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 59 3e-08 gi|54607135 translocase of outer mitochondrial membrane 70 homol... 57 8e-08 gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 55 2e-07 gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 55 2e-07 gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 52 3e-06 gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sap... 51 4e-06 gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo sap... 51 4e-06 gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sap... 51 4e-06 gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ... 50 7e-06 gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens] 50 1e-05 gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo sap... 49 3e-05 gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo sap... 49 3e-05 gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo sap... 49 3e-05 gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo sap... 49 3e-05 gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo sapi... 49 3e-05 gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 47 6e-05 gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa... 47 8e-05 gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa... 47 8e-05 gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa... 47 8e-05 gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 47 8e-05 >gi|224809432 transmembrane and tetratricopeptide repeat containing 3 [Homo sapiens] Length = 914 Score = 1813 bits (4697), Expect = 0.0 Identities = 914/914 (100%), Positives = 914/914 (100%) Query: 1 MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP 60 MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP Sbjct: 1 MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTP 60 Query: 61 MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS 120 MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS Sbjct: 61 MSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSS 120 Query: 121 VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL 180 VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL Sbjct: 121 VIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFL 180 Query: 181 VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI 240 VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI Sbjct: 181 VAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLI 240 Query: 241 VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL 300 VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL Sbjct: 241 VLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSEL 300 Query: 301 CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI 360 CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI Sbjct: 301 CCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFI 360 Query: 361 PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK 420 PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK Sbjct: 361 PASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSWICLSMVILTHSLK 420 Query: 421 TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI 480 TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI Sbjct: 421 TFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDI 480 Query: 481 GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA 540 GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA Sbjct: 481 GAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRA 540 Query: 541 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW 600 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW Sbjct: 541 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW 600 Query: 601 YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY 660 YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY Sbjct: 601 YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY 660 Query: 661 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK 720 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK Sbjct: 661 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK 720 Query: 721 ALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVV 780 ALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVV Sbjct: 721 ALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVV 780 Query: 781 YFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKK 840 YFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKK Sbjct: 781 YFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKK 840 Query: 841 IPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAA 900 IPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAA Sbjct: 841 IPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAA 900 Query: 901 LKRLEEIERILNGE 914 LKRLEEIERILNGE Sbjct: 901 LKRLEEIERILNGE 914 >gi|118766328 transmembrane and tetratricopeptide repeat containing 4 isoform 2 [Homo sapiens] Length = 741 Score = 392 bits (1006), Expect = e-108 Identities = 248/694 (35%), Positives = 383/694 (55%), Gaps = 49/694 (7%) Query: 11 LIVG-VVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKS 69 L+VG V C+ S FVFDD AI++NKDL TPL L+ +DFWG+ +S SHKS Sbjct: 24 LVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKS 83 Query: 70 YRPLTVLTFRLNYLLSE-LKPMSYHLLNMIFHAVVSVIFLKVC--------------KLF 114 YRPLTVLTFR+NY LS P+ +H++N++ H+ +SV+ + V +L Sbjct: 84 YRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLH 143 Query: 115 LDNKSSVIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRS------KGPDNS 168 L ++S++A+LLFAVHP+HTE V GVVGRA+LL ++FFL +FL Y ++ +G +S Sbjct: 144 LAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSS 203 Query: 169 IIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSI 228 W + L++FL AVA LCKEQGITV+G+ V+++ + + + L + K Sbjct: 204 TFW--VLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNV--LEIVQKVLHKDKSLE 259 Query: 229 PFSMLQT---LVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTP-TRQLTFN 284 ML+ L ++ +L ++ +R +++ + P FT DNPA+ + + R + +N Sbjct: 260 NLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYN 319 Query: 285 YLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFT-FFCFLGMLGVFSIRYSGD 343 Y +NAWLLL P LC DW+MG IPLI+S+ D R +A +FC +G++ G Sbjct: 320 YYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGH 379 Query: 344 SSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFK 403 + + + L + +PF+PASNLFF VGFVVAERVLY+PS+G+C+L+ G+ +S + K Sbjct: 380 KRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKK 439 Query: 404 KLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFE 463 KL + ++ ++L+ R+ +W SE LF SAL V NAK+ N+G L ++ N Sbjct: 440 KLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQT 499 Query: 464 RALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARI 523 A++Y+ +A + P + A N+G K N +EAEE + A +I Sbjct: 500 AAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSL--------------AVQI 545 Query: 524 APNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAK 583 P+ ++NL +++ + R E A+Q YR AI R + Y + G L +N+ + A Sbjct: 546 QPDFAAAWMNL-GIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDAL 604 Query: 584 EAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQE 643 A+ A L ++ W N+ I+ +A ALEL P +F+ A V+ + Sbjct: 605 NAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGK 664 Query: 644 SGEVKLRPEARKRLLSYINEEPLDANGYFNLGML 677 S + K E+ L I P A+ + NL +L Sbjct: 665 SQKYK---ESEALFLKAIKANPNAASYHGNLAVL 695 Score = 55.8 bits (133), Expect = 2e-07 Identities = 52/241 (21%), Positives = 107/241 (44%), Gaps = 10/241 (4%) Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625 +I+ +L+ + ++ + AL + NA + YN+ + A++ + A+ Sbjct: 451 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 510 Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685 LNPK+ A+ N +++E E++ EA + L + +P A + NLG++ K+ Sbjct: 511 LNPKYVHAMNNLGNILKERNELQ---EAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFE 567 Query: 686 EAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHI---KGLILK 742 AE + AIK + + +NL LY+ + + AL P+H +I Sbjct: 568 AAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMI-- 625 Query: 743 GDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP 802 IL++ ++ A+ LE+ P++ +L V + + ++E L+ + P Sbjct: 626 --ILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANP 683 Query: 803 H 803 + Sbjct: 684 N 684 >gi|118766330 transmembrane and tetratricopeptide repeat containing 4 isoform 1 [Homo sapiens] Length = 760 Score = 392 bits (1006), Expect = e-108 Identities = 248/694 (35%), Positives = 383/694 (55%), Gaps = 49/694 (7%) Query: 11 LIVG-VVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKS 69 L+VG V C+ S FVFDD AI++NKDL TPL L+ +DFWG+ +S SHKS Sbjct: 43 LVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKS 102 Query: 70 YRPLTVLTFRLNYLLSE-LKPMSYHLLNMIFHAVVSVIFLKVC--------------KLF 114 YRPLTVLTFR+NY LS P+ +H++N++ H+ +SV+ + V +L Sbjct: 103 YRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLH 162 Query: 115 LDNKSSVIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRS------KGPDNS 168 L ++S++A+LLFAVHP+HTE V GVVGRA+LL ++FFL +FL Y ++ +G +S Sbjct: 163 LAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSS 222 Query: 169 IIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSI 228 W + L++FL AVA LCKEQGITV+G+ V+++ + + + L + K Sbjct: 223 TFW--VLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNV--LEIVQKVLHKDKSLE 278 Query: 229 PFSMLQT---LVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTP-TRQLTFN 284 ML+ L ++ +L ++ +R +++ + P FT DNPA+ + + R + +N Sbjct: 279 NLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYN 338 Query: 285 YLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFT-FFCFLGMLGVFSIRYSGD 343 Y +NAWLLL P LC DW+MG IPLI+S+ D R +A +FC +G++ G Sbjct: 339 YYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGH 398 Query: 344 SSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFK 403 + + + L + +PF+PASNLFF VGFVVAERVLY+PS+G+C+L+ G+ +S + K Sbjct: 399 KRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKK 458 Query: 404 KLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFE 463 KL + ++ ++L+ R+ +W SE LF SAL V NAK+ N+G L ++ N Sbjct: 459 KLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQT 518 Query: 464 RALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARI 523 A++Y+ +A + P + A N+G K N +EAEE + A +I Sbjct: 519 AAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSL--------------AVQI 564 Query: 524 APNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAK 583 P+ ++NL +++ + R E A+Q YR AI R + Y + G L +N+ + A Sbjct: 565 QPDFAAAWMNL-GIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDAL 623 Query: 584 EAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQE 643 A+ A L ++ W N+ I+ +A ALEL P +F+ A V+ + Sbjct: 624 NAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGK 683 Query: 644 SGEVKLRPEARKRLLSYINEEPLDANGYFNLGML 677 S + K E+ L I P A+ + NL +L Sbjct: 684 SQKYK---ESEALFLKAIKANPNAASYHGNLAVL 714 Score = 55.8 bits (133), Expect = 2e-07 Identities = 52/241 (21%), Positives = 107/241 (44%), Gaps = 10/241 (4%) Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625 +I+ +L+ + ++ + AL + NA + YN+ + A++ + A+ Sbjct: 470 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 529 Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685 LNPK+ A+ N +++E E++ EA + L + +P A + NLG++ K+ Sbjct: 530 LNPKYVHAMNNLGNILKERNELQ---EAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFE 586 Query: 686 EAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHI---KGLILK 742 AE + AIK + + +NL LY+ + + AL P+H +I Sbjct: 587 AAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMI-- 644 Query: 743 GDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP 802 IL++ ++ A+ LE+ P++ +L V + + ++E L+ + P Sbjct: 645 --ILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANP 702 Query: 803 H 803 + Sbjct: 703 N 703 >gi|22749211 transmembrane and tetratricopeptide repeat containing 2 [Homo sapiens] Length = 836 Score = 325 bits (834), Expect = 9e-89 Identities = 246/822 (29%), Positives = 390/822 (47%), Gaps = 124/822 (15%) Query: 18 ACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLT 77 A Y N+L F +DD AI N+DL P TP +F NDFWGT ++ SHKSYRPL L+ Sbjct: 13 ALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLS 72 Query: 78 FRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFL-DNKSSVIASLLFAVHPIHTEA 136 FRLN+ + L P SYHL+N++ HA V+ +F K+ L D + +A L+FA HPIHTEA Sbjct: 73 FRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEA 132 Query: 137 VTGVVGRAELLSSIFFLAAFLSYTR--SKGPDNSIIWTPIALTVFLVAVATLCKEQGITV 194 V G+VGRA++ +S+FFL + L Y + S ++ W + + L KEQG+TV Sbjct: 133 VAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTV 192 Query: 195 VGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRV 254 + + VY+VF+ + + T + K L + + +L+F L+ R+ Sbjct: 193 LAVSAVYDVFVFHRLKIKQILPT---IYKRKN------LSLFLSISLLIFWGSSLLGARL 243 Query: 255 QVIQSQLPVFTRFDNPAAVSPTP-TRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIE 313 + ++ P F+ DNPAA S + TR LTF YL N WLLL P L DW+M +PL++ Sbjct: 244 YWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLK 303 Query: 314 SLLDIRNLATFTFFCFLGMLGVFSIR------------------------------YSGD 343 ++ D RNL T F+ L +L + ++ Y Sbjct: 304 TVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNS 363 Query: 344 SSKT--------------------------VLMALCLMALPFIPASNLFFPVGFVVAERV 377 +K+ V+++L L+ +PF+PA+NLFF VGFV+AERV Sbjct: 364 ETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERV 423 Query: 378 LYVPSMGFCILVAHGWQKIST---KSVFKKLSWICLSMVILTHSLKTFHRNWDWESEYTL 434 LY+PSMGFC+L+ G + + K K L + + +I+ + LKT RN DW++E L Sbjct: 424 LYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEML 483 Query: 435 FMSALKVNKNNAKLWNNVGHALENE----------------------------------K 460 + S +KVN AK W N+G+ L+++ Sbjct: 484 YRSGIKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENS 541 Query: 461 NFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYA 520 F AL Y+ A +P A++N G N RT+EA +++ + + + K Sbjct: 542 RFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENL---KDP 598 Query: 521 ARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDF---KQAYISRGELLLKMN 577 + + NL L + EEA +Y++AI P + Y GE ++++ Sbjct: 599 HAHKSSVTSCLYNLGKLYH-EQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLS 657 Query: 578 KPLKAKEAYLKAL--ELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNP-KHKLAL 634 K +A+ Y+++L + D A L Y + K +EA K F +A+EL+P K + Sbjct: 658 KLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRK--SEAEKLFLKAIELDPTKGNCYM 715 Query: 635 FNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKA 694 +++E+ ++ A+K + ++ D FN + + AE + A Sbjct: 716 HYGQFLLEEARLIEAAEMAKK--AAELDSTEFDV--VFNAAHMLRQASLNEAAEKYYDLA 771 Query: 695 IKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHI 736 +L+ ++ +AL NL + + KA L+ PD + Sbjct: 772 ARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDV 813 >gi|83415184 transmembrane and tetratricopeptide repeat containing 1 [Homo sapiens] Length = 774 Score = 215 bits (547), Expect = 2e-55 Identities = 161/562 (28%), Positives = 272/562 (48%), Gaps = 65/562 (11%) Query: 279 RQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSI 338 R LT++YLL N WLLL P LC DW +G+IPL+E++ D+RNLAT + +L + + Sbjct: 205 RFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCL 264 Query: 339 R-YSGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKIS 397 + K VL+ L + PFIPASNLFF VGFVVAERVLY+PSMG+CIL HG K+ Sbjct: 265 AAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLC 324 Query: 398 TKSVFKKLSWICLS--MVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHA 455 T + + +S +++L S KT +N W S +LF S ++ +NAK+ N + Sbjct: 325 TWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANF 384 Query: 456 LENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIP 515 L+++ + A+ ++ A + P A N+G ++ T EA+ Y A L PQ Sbjct: 385 LKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRD---TAEAKMYYQRALQLHPQ--- 438 Query: 516 GKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLK 575 H NL NL+++ E + EEA L + +I P+F AY S LL + Sbjct: 439 -----------HNRALFNLGNLLKSQEKK-EEAITLLKDSIKYGPEFADAYSSLASLLAE 486 Query: 576 MNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALF 635 + +A+E Y ++ +++DL N + ++ P +A+ ++ +A++L+P H +A+ Sbjct: 487 QERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMV 546 Query: 636 NSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAI 695 N LG L +++ AE W K+A+ Sbjct: 547 N-------------------------------------LGRLYRSLGENSMAEEWYKRAL 569 Query: 696 KLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDIL--MNQKKDI 753 ++ A L L LY T + +AL I +E P + + +L M Q K+ Sbjct: 570 QV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKE- 627 Query: 754 LGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNI 813 A+K I+ + ++ L +Y ++++ KA + + L L P + + L Sbjct: 628 --AEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFF 685 Query: 814 VR-DKISSSSFIEPIFPTSKIS 834 + +++ + ++ F + +++ Sbjct: 686 TKGNQLREQNLLDKAFESYRVA 707 Score = 100 bits (249), Expect = 6e-21 Identities = 54/127 (42%), Positives = 80/127 (62%), Gaps = 9/127 (7%) Query: 87 LKPMSYHLLNMIFHAVVSVIFLKVCK--LFLDNKSSVIASLLFAVHPIHTEAVTGVVGRA 144 + P +H +N+I H +V+++ + C +F + + + +LLFAVHPIHTEAV G+VGRA Sbjct: 1 MNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRA 60 Query: 145 ELLSSIFFLAAFLSYTRS-----KGPDNSIIWTP--IALTVFLVAVATLCKEQGITVVGI 197 ++L+ + FL AFLSY RS G +P + L++FL A L KE GITV G+ Sbjct: 61 DVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGV 120 Query: 198 CCVYEVF 204 C VY++F Sbjct: 121 CLVYDLF 127 Score = 70.9 bits (172), Expect = 5e-12 Identities = 62/281 (22%), Positives = 131/281 (46%), Gaps = 21/281 (7%) Query: 434 LFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNL 493 ++ + +K +++ L NN G L + E+A+ ++ QA + P A +N+GR Y++L Sbjct: 496 IYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSL 555 Query: 494 NRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYR 553 AEE Y K A ++A H ++ + N R EEA Q+Y+ Sbjct: 556 GENSMAEEWY--------------KRALQVA--HKAEILSPLGALYYNTGRYEEALQIYQ 599 Query: 554 QAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEP 613 +A +++P ++ ++ ++L M + +A++ + + + + L+ ++ + + Sbjct: 600 EAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENH 659 Query: 614 NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY---INEEPLDANG 670 ++AL ++AL+L PK + S + + +++ + K SY + P A Sbjct: 660 DKALDAIDKALQLKPKDPKVI--SELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQA 717 Query: 671 YFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALL 711 + N+G + K A + ++A++L D + NLA L Sbjct: 718 WMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKL 758 >gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] Length = 1036 Score = 108 bits (269), Expect = 3e-23 Identities = 93/385 (24%), Positives = 172/385 (44%), Gaps = 25/385 (6%) Query: 438 ALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTK 497 A+K N A+ ++N+G+ + + A++++ A ++PD I ++N+ + Sbjct: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130 Query: 498 EAEESYMMAKSLMPQIIPGKK--------------------YAARIAPNHLNVYINLANL 537 A ++Y+ A P + + A PN + NL + Sbjct: 131 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 190 Query: 538 IRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNA 597 A + + A + +A+++ P+F AYI+ G +L + +A AYL+AL L N+A Sbjct: 191 FNA-QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHA 249 Query: 598 DLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRL 657 + NLA V+ E + A+ + RA+EL P A N A ++E G V EA Sbjct: 250 VVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSV---AEAEDCY 306 Query: 658 LSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAK 717 + + P A+ NL + + EA +KA+++ +F +A NLA + Q K Sbjct: 307 NTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGK 366 Query: 718 ELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNL 777 +AL +E +R P G+ L + +D+ GA +C+ R ++++P+ NL Sbjct: 367 LQEALMHYKEAIRISPTFADAYSNMGNTL-KEMQDVQGALQCYTRAIQINPAFADAHSNL 425 Query: 778 CVVYFEEKDLLKAERCLLETLALAP 802 ++ + ++ +A L L P Sbjct: 426 ASIHKDSGNIPEAIASYRTALKLKP 450 Score = 102 bits (254), Expect = 2e-21 Identities = 80/306 (26%), Positives = 138/306 (45%), Gaps = 18/306 (5%) Query: 429 ESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGR 488 E ++ A++ N A W+N+G + A+ +F +A + P+ + A++N+G Sbjct: 164 EEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN 223 Query: 489 TYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEA 548 K A +Y+ A SL +PNH V+ NLA + + ++ A Sbjct: 224 VLKEARIFDRAVAAYLRALSL--------------SPNHAVVHGNLA-CVYYEQGLIDLA 268 Query: 549 DQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHI 608 YR+AI ++P F AY + L + +A++ Y AL L +AD NLA + Sbjct: 269 IDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKR 328 Query: 609 ELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDA 668 E EA++ + +ALE+ P+ A N A V+Q+ G+++ EA I P A Sbjct: 329 EQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQ---EALMHYKEAIRISPTFA 385 Query: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728 + Y N+G + + A +AI++ F A NLA ++ + +A+ Sbjct: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445 Query: 729 LRYYPD 734 L+ PD Sbjct: 446 LKLKPD 451 Score = 88.2 bits (217), Expect = 3e-17 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 24/286 (8%) Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494 F A+ ++ N + N+G+ L+ + F+RA+ +L+A + P+ H N+ Y Sbjct: 204 FEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQG 263 Query: 495 RTKEAEESYMMAKSLMPQIIPGK--------------------KYAARIAPNHLNVYINL 534 A ++Y A L P A R+ P H + NL Sbjct: 264 LIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNL 323 Query: 535 ANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDR 594 AN I+ + +EEA +LYR+A+ + P+F A+ + +L + K +A Y +A+ + Sbjct: 324 AN-IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP 382 Query: 595 NNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEAR 654 AD + N+ E+++ AL+ + RA+++NP A N A + ++SG + PEA Sbjct: 383 TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI---PEAI 439 Query: 655 KRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQAD 700 + + +P + Y NL + + MKK + + AD Sbjct: 440 ASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD 485 Score = 59.3 bits (142), Expect = 2e-08 Identities = 71/304 (23%), Positives = 130/304 (42%), Gaps = 20/304 (6%) Query: 522 RIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLK 581 R P++ V + L++ I RL+ + AI P +AY + G + + + + Sbjct: 39 RQEPDNTGVLLLLSS-IHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE 97 Query: 582 AKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641 A E Y AL L + D + NLA + + A++ + AL+ NP + ++ Sbjct: 98 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL 157 Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWM-----KKAIK 696 + G ++ EA+ L I +P A + NLG + + + EIW+ +KA+ Sbjct: 158 KALGRLE---EAKACYLKAIETQPNFAVAWSNLGCVF-----NAQGEIWLAIHHFEKAVT 209 Query: 697 LQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDI--LMNQKKDIL 754 L +F A NL + + +A+ L P+H ++ G++ + ++ I Sbjct: 210 LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH---AVVHGNLACVYYEQGLID 266 Query: 755 GAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP-HEEYIQRHLNI 813 A + R +E+ P NL E+ + +AE C L L P H + + NI Sbjct: 267 LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANI 326 Query: 814 VRDK 817 R++ Sbjct: 327 KREQ 330 >gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] Length = 1046 Score = 108 bits (269), Expect = 3e-23 Identities = 93/385 (24%), Positives = 172/385 (44%), Gaps = 25/385 (6%) Query: 438 ALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTK 497 A+K N A+ ++N+G+ + + A++++ A ++PD I ++N+ + Sbjct: 81 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 140 Query: 498 EAEESYMMAKSLMPQIIPGKK--------------------YAARIAPNHLNVYINLANL 537 A ++Y+ A P + + A PN + NL + Sbjct: 141 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 200 Query: 538 IRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNA 597 A + + A + +A+++ P+F AYI+ G +L + +A AYL+AL L N+A Sbjct: 201 FNA-QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHA 259 Query: 598 DLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRL 657 + NLA V+ E + A+ + RA+EL P A N A ++E G V EA Sbjct: 260 VVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSV---AEAEDCY 316 Query: 658 LSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAK 717 + + P A+ NL + + EA +KA+++ +F +A NLA + Q K Sbjct: 317 NTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGK 376 Query: 718 ELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNL 777 +AL +E +R P G+ L + +D+ GA +C+ R ++++P+ NL Sbjct: 377 LQEALMHYKEAIRISPTFADAYSNMGNTL-KEMQDVQGALQCYTRAIQINPAFADAHSNL 435 Query: 778 CVVYFEEKDLLKAERCLLETLALAP 802 ++ + ++ +A L L P Sbjct: 436 ASIHKDSGNIPEAIASYRTALKLKP 460 Score = 102 bits (254), Expect = 2e-21 Identities = 80/306 (26%), Positives = 138/306 (45%), Gaps = 18/306 (5%) Query: 429 ESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGR 488 E ++ A++ N A W+N+G + A+ +F +A + P+ + A++N+G Sbjct: 174 EEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN 233 Query: 489 TYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEA 548 K A +Y+ A SL +PNH V+ NLA + + ++ A Sbjct: 234 VLKEARIFDRAVAAYLRALSL--------------SPNHAVVHGNLA-CVYYEQGLIDLA 278 Query: 549 DQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHI 608 YR+AI ++P F AY + L + +A++ Y AL L +AD NLA + Sbjct: 279 IDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKR 338 Query: 609 ELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDA 668 E EA++ + +ALE+ P+ A N A V+Q+ G+++ EA I P A Sbjct: 339 EQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQ---EALMHYKEAIRISPTFA 395 Query: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728 + Y N+G + + A +AI++ F A NLA ++ + +A+ Sbjct: 396 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 455 Query: 729 LRYYPD 734 L+ PD Sbjct: 456 LKLKPD 461 Score = 88.2 bits (217), Expect = 3e-17 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 24/286 (8%) Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494 F A+ ++ N + N+G+ L+ + F+RA+ +L+A + P+ H N+ Y Sbjct: 214 FEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQG 273 Query: 495 RTKEAEESYMMAKSLMPQIIPGK--------------------KYAARIAPNHLNVYINL 534 A ++Y A L P A R+ P H + NL Sbjct: 274 LIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNL 333 Query: 535 ANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDR 594 AN I+ + +EEA +LYR+A+ + P+F A+ + +L + K +A Y +A+ + Sbjct: 334 AN-IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP 392 Query: 595 NNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEAR 654 AD + N+ E+++ AL+ + RA+++NP A N A + ++SG + PEA Sbjct: 393 TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI---PEAI 449 Query: 655 KRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQAD 700 + + +P + Y NL + + MKK + + AD Sbjct: 450 ASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD 495 Score = 59.3 bits (142), Expect = 2e-08 Identities = 71/304 (23%), Positives = 130/304 (42%), Gaps = 20/304 (6%) Query: 522 RIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLK 581 R P++ V + L++ I RL+ + AI P +AY + G + + + + Sbjct: 49 RQEPDNTGVLLLLSS-IHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE 107 Query: 582 AKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641 A E Y AL L + D + NLA + + A++ + AL+ NP + ++ Sbjct: 108 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLL 167 Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWM-----KKAIK 696 + G ++ EA+ L I +P A + NLG + + + EIW+ +KA+ Sbjct: 168 KALGRLE---EAKACYLKAIETQPNFAVAWSNLGCVF-----NAQGEIWLAIHHFEKAVT 219 Query: 697 LQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDI--LMNQKKDIL 754 L +F A NL + + +A+ L P+H ++ G++ + ++ I Sbjct: 220 LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH---AVVHGNLACVYYEQGLID 276 Query: 755 GAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP-HEEYIQRHLNI 813 A + R +E+ P NL E+ + +AE C L L P H + + NI Sbjct: 277 LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANI 336 Query: 814 VRDK 817 R++ Sbjct: 337 KREQ 340 >gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] Length = 519 Score = 72.8 bits (177), Expect = 1e-12 Identities = 95/431 (22%), Positives = 173/431 (40%), Gaps = 33/431 (7%) Query: 459 EKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKK 518 E N + +L+ F + P V R+ L + K A E Y A L + Sbjct: 80 EGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKL-------NQ 132 Query: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578 I+ N YI L +A DQL+ R D YI G++ L Sbjct: 133 KDWEISHNLGVCYIYLKQFNKAQ-------DQLHNALNLNRHDL--TYIMLGKIHLLEGD 183 Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638 KA E Y KA+E N +L L +++++L +A ++ AL +P + A+ + Sbjct: 184 LDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAG 243 Query: 639 IVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQ 698 +MQ G+ + + + + E P N N+GM KK A +K+A L Sbjct: 244 SMMQTHGDFDVALTKYRVVACAVPESPPLWN---NIGMCFFGKKKYVAAISCLKRANYLA 300 Query: 699 ADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKK 758 L+NL L++ + A L + + P + L + + + +DI AK+ Sbjct: 301 PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQP-KMGELYMLLAVALTNLEDIENAKR 359 Query: 759 CFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKI 818 + + +D N N V+ + + + + ALA ++E +++ +++++D Sbjct: 360 AYAEAVHLDKCNPLVNLNYAVLLYNQGE---------KKNALAQYQE-MEKKVSLLKDNS 409 Query: 819 S---SSSFIEPIFPTSKISSVEGKKIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLG 875 S S +E V + T+ VK+ + + + T K + + SN+ LG Sbjct: 410 SLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQQPLGSNQALG 469 Query: 876 KNGDEETPHKT 886 + ++T Sbjct: 470 QAMSSAAAYRT 480 Score = 55.8 bits (133), Expect = 2e-07 Identities = 64/279 (22%), Positives = 110/279 (39%), Gaps = 41/279 (14%) Query: 537 LIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNN 596 LI E ++E+ +L++ + P L + K A E Y +A +L++ + Sbjct: 75 LIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKD 134 Query: 597 ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKR 656 ++ +NL + +I LK+ N+A + AL LN +H L Sbjct: 135 WEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLT----------------------- 170 Query: 657 LLSYINEEPLDANGYFNLGML-AMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQT 715 Y LG + ++ D E++ KKA++ + L L LLY Q Sbjct: 171 --------------YIMLGKIHLLEGDLDKAIEVY-KKAVEFSPENTELLTTLGLLYLQL 215 Query: 716 AKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKH 775 KA L L Y P + K ++ G +M D A + + P + + Sbjct: 216 GIYQKAFEHLGNALTYDPTNYKAILAAGS-MMQTHGDFDVALTKYRVVACAVPESPPLWN 274 Query: 776 NLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIV 814 N+ + +F +K + A CL LAP + I +L +V Sbjct: 275 NIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLV 313 Score = 32.0 bits (71), Expect = 2.7 Identities = 34/167 (20%), Positives = 68/167 (40%), Gaps = 18/167 (10%) Query: 448 LWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAK 507 LWNN+G +K + A+ +A ++ P D N+G + + + A A Sbjct: 272 LWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAI 331 Query: 508 SLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYI 567 + P++ G+ Y + + + L NL +E A + Y +A+ + + Sbjct: 332 NFQPKM--GELY--------MLLAVALTNL-----EDIENAKRAYAEAVHLDKCNPLVNL 376 Query: 568 SRGELLLKMNKPLKAKEAYL---KALELDRNNADLWYNLAIVHIELK 611 + LL + A Y K + L ++N+ L ++ +V + K Sbjct: 377 NYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEFDSEMVEMAQK 423 >gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo sapiens] Length = 1614 Score = 58.5 bits (140), Expect = 3e-08 Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%) Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494 F A +++ N L + FE A+ +F A + P + A++ G +Y Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352 Query: 495 R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551 TK+A++ ++ A I P ++ I+ ++A + + ++A Sbjct: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397 Query: 552 YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611 + AI P AY R + L+M A + A+++ A+ N ++H + Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456 Query: 612 EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671 A+K++ A+ LNPK+ LA Y Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479 Query: 672 FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731 FN G + ++ ++A + KA+K + L N A I +L+ Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525 Query: 732 YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791 Y + AK+ F ++E P N Y+ K AE Sbjct: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564 Query: 792 RCLLETLALAPHEEYIQRHLNIVRDKI 818 L + L+L P++ + VR KI Sbjct: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591 Score = 55.5 bits (132), Expect = 2e-07 Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%) Query: 402 FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457 FK+ + I + L H+ HR ++E F ALK+N + G++ Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352 Query: 458 NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512 +++ ++A K FL+A H+ P I A ++ G + + ++A + +A P+ Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412 Query: 513 -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559 + G +AA N ++ +I + A + Y+ AI++ Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472 Query: 560 PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619 P + AY + G + + +A + + KAL+ D N + N AI + LK+ EA ++ Sbjct: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532 Query: 620 FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671 F +E P FN A + +L E + LS +P DA Y Sbjct: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581 Score = 43.9 bits (102), Expect = 7e-04 Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%) Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625 +++RG + +++ + A E + +A + R N L + A+ H + E EA+ F AL+ Sbjct: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332 Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685 +NP A E G + +A+K L ++ P + G K Sbjct: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392 Query: 686 EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743 +A W I + D ++ A A++ Q A+ + ++ + L +G Sbjct: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449 Query: 744 DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801 I M K++ A K ++ + ++P N +YF + +A + L Sbjct: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506 Query: 802 PHEEYI 807 P EY+ Sbjct: 1507 PENEYV 1512 Score = 39.3 bits (90), Expect = 0.017 Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%) Query: 437 SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496 +A+K++ A+ N G E + + A+K + A + P A+ N G Y + + Sbjct: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492 Query: 497 KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554 +A + + A P+ N Y+ L N N + EEA + + Sbjct: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535 Query: 555 AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614 I P + Y +R + + A+E KAL L N+A ++ A V ++ Sbjct: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595 Query: 615 EALKNFNRALEL 626 EA+ ++N+AL+L Sbjct: 1596 EAMADYNQALDL 1607 Score = 32.3 bits (72), Expect = 2.1 Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%) Query: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578 Y + N+ Y++ A + R + + A Y QAI P Y RGE+ NK Sbjct: 976 YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034 Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638 L A + + K + D D + + E + A+++F L ++ ++ A Sbjct: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093 Query: 639 IVMQ 642 ++M+ Sbjct: 1094 LMMK 1097 >gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo sapiens] Length = 1614 Score = 58.5 bits (140), Expect = 3e-08 Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%) Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494 F A +++ N L + FE A+ +F A + P + A++ G +Y Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352 Query: 495 R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551 TK+A++ ++ A I P ++ I+ ++A + + ++A Sbjct: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397 Query: 552 YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611 + AI P AY R + L+M A + A+++ A+ N ++H + Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456 Query: 612 EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671 A+K++ A+ LNPK+ LA Y Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479 Query: 672 FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731 FN G + ++ ++A + KA+K + L N A I +L+ Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525 Query: 732 YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791 Y + AK+ F ++E P N Y+ K AE Sbjct: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564 Query: 792 RCLLETLALAPHEEYIQRHLNIVRDKI 818 L + L+L P++ + VR KI Sbjct: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591 Score = 55.5 bits (132), Expect = 2e-07 Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%) Query: 402 FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457 FK+ + I + L H+ HR ++E F ALK+N + G++ Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352 Query: 458 NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512 +++ ++A K FL+A H+ P I A ++ G + + ++A + +A P+ Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412 Query: 513 -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559 + G +AA N ++ +I + A + Y+ AI++ Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472 Query: 560 PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619 P + AY + G + + +A + + KAL+ D N + N AI + LK+ EA ++ Sbjct: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532 Query: 620 FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671 F +E P FN A + +L E + LS +P DA Y Sbjct: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581 Score = 43.9 bits (102), Expect = 7e-04 Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%) Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625 +++RG + +++ + A E + +A + R N L + A+ H + E EA+ F AL+ Sbjct: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332 Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685 +NP A E G + +A+K L ++ P + G K Sbjct: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392 Query: 686 EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743 +A W I + D ++ A A++ Q A+ + ++ + L +G Sbjct: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449 Query: 744 DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801 I M K++ A K ++ + ++P N +YF + +A + L Sbjct: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506 Query: 802 PHEEYI 807 P EY+ Sbjct: 1507 PENEYV 1512 Score = 39.3 bits (90), Expect = 0.017 Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%) Query: 437 SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496 +A+K++ A+ N G E + + A+K + A + P A+ N G Y + + Sbjct: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492 Query: 497 KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554 +A + + A P+ N Y+ L N N + EEA + + Sbjct: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535 Query: 555 AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614 I P + Y +R + + A+E KAL L N+A ++ A V ++ Sbjct: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595 Query: 615 EALKNFNRALEL 626 EA+ ++N+AL+L Sbjct: 1596 EAMADYNQALDL 1607 Score = 32.3 bits (72), Expect = 2.1 Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%) Query: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578 Y + N+ Y++ A + R + + A Y QAI P Y RGE+ NK Sbjct: 976 YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034 Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638 L A + + K + D D + + E + A+++F L ++ ++ A Sbjct: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093 Query: 639 IVMQ 642 ++M+ Sbjct: 1094 LMMK 1097 >gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo sapiens] Length = 1614 Score = 58.5 bits (140), Expect = 3e-08 Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%) Query: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494 F A +++ N L + FE A+ +F A + P + A++ G +Y Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352 Query: 495 R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551 TK+A++ ++ A I P ++ I+ ++A + + ++A Sbjct: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397 Query: 552 YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611 + AI P AY R + L+M A + A+++ A+ N ++H + Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456 Query: 612 EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671 A+K++ A+ LNPK+ LA Y Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479 Query: 672 FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731 FN G + ++ ++A + KA+K + L N A I +L+ Sbjct: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525 Query: 732 YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791 Y + AK+ F ++E P N Y+ K AE Sbjct: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564 Query: 792 RCLLETLALAPHEEYIQRHLNIVRDKI 818 L + L+L P++ + VR KI Sbjct: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591 Score = 55.5 bits (132), Expect = 2e-07 Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%) Query: 402 FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457 FK+ + I + L H+ HR ++E F ALK+N + G++ Sbjct: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352 Query: 458 NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512 +++ ++A K FL+A H+ P I A ++ G + + ++A + +A P+ Sbjct: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412 Query: 513 -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559 + G +AA N ++ +I + A + Y+ AI++ Sbjct: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472 Query: 560 PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619 P + AY + G + + +A + + KAL+ D N + N AI + LK+ EA ++ Sbjct: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532 Query: 620 FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671 F +E P FN A + +L E + LS +P DA Y Sbjct: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581 Score = 43.9 bits (102), Expect = 7e-04 Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%) Query: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625 +++RG + +++ + A E + +A + R N L + A+ H + E EA+ F AL+ Sbjct: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332 Query: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685 +NP A E G + +A+K L ++ P + G K Sbjct: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392 Query: 686 EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743 +A W I + D ++ A A++ Q A+ + ++ + L +G Sbjct: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449 Query: 744 DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801 I M K++ A K ++ + ++P N +YF + +A + L Sbjct: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506 Query: 802 PHEEYI 807 P EY+ Sbjct: 1507 PENEYV 1512 Score = 39.3 bits (90), Expect = 0.017 Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%) Query: 437 SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496 +A+K++ A+ N G E + + A+K + A + P A+ N G Y + + Sbjct: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492 Query: 497 KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554 +A + + A P+ N Y+ L N N + EEA + + Sbjct: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535 Query: 555 AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614 I P + Y +R + + A+E KAL L N+A ++ A V ++ Sbjct: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595 Query: 615 EALKNFNRALEL 626 EA+ ++N+AL+L Sbjct: 1596 EAMADYNQALDL 1607 Score = 32.3 bits (72), Expect = 2.1 Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%) Query: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578 Y + N+ Y++ A + R + + A Y QAI P Y RGE+ NK Sbjct: 976 YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034 Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638 L A + + K + D D + + E + A+++F L ++ ++ A Sbjct: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093 Query: 639 IVMQ 642 ++M+ Sbjct: 1094 LMMK 1097 >gi|54607135 translocase of outer mitochondrial membrane 70 homolog A [Homo sapiens] Length = 608 Score = 57.0 bits (136), Expect = 8e-08 Identities = 49/209 (23%), Positives = 91/209 (43%), Gaps = 14/209 (6%) Query: 518 KYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMN 577 KY A Y+ + N A + L++ L + +R + A I RG + ++ Sbjct: 326 KYMAEALLLRATFYLLIGNA-NAAKPDLDKVISLKEANVKLRAN---ALIKRGSMYMQQQ 381 Query: 578 KPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKL----- 632 +PL + + + A ++D NAD++++ + I L + EA+ +F+ + L P+ L Sbjct: 382 QPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQK 441 Query: 633 --ALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIW 690 AL+ A S +++ A K I + P A GY D ++ +A+ Sbjct: 442 CFALYRQAYTGNNSSQIQ---AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEM 498 Query: 691 MKKAIKLQADFRSALFNLALLYSQTAKEL 719 K I L+ D + + LL Q ++L Sbjct: 499 YDKCIDLEPDNATTYVHKGLLQLQWKQDL 527 Score = 42.0 bits (97), Expect = 0.003 Identities = 24/88 (27%), Positives = 47/88 (53%), Gaps = 3/88 (3%) Query: 541 NESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPL-KAKEAYLKALELDRNNADL 599 ++ + +AD++Y + I + PD Y+ +G L L+ + L + E KA+E+D N D Sbjct: 488 DQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEID-NKCDF 546 Query: 600 WYN-LAIVHIELKEPNEALKNFNRALEL 626 Y + + ++ +A+ FN+A+ L Sbjct: 547 AYETMGTIEVQRGNMEKAIDMFNKAINL 574 Score = 37.4 bits (85), Expect = 0.064 Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 5/83 (6%) Query: 561 DFKQAYISRGELLLKMNKPLKAKEAYLKALEL--DRNNADL---WYNLAIVHIELKEPNE 615 D QA ++G K K +A + Y +A+ L N DL + N A +L++ E Sbjct: 112 DRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKE 171 Query: 616 ALKNFNRALELNPKHKLALFNSA 638 ++ +A+ELNPK+ ALF A Sbjct: 172 VAQDCTKAVELNPKYVKALFRRA 194 >gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapiens] Length = 830 Score = 55.5 bits (132), Expect = 2e-07 Identities = 41/156 (26%), Positives = 77/156 (49%), Gaps = 4/156 (2%) Query: 520 AARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKP 579 A ++ PN+ Y L + E L++A +R AI + P A+ G + K K Sbjct: 599 AIQVDPNYAYAYTLLGHEFVLTEE-LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKF 657 Query: 580 LKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639 A+ + KAL+++ ++ L ++ +V LK+ +AL N+A+ ++PK+ L F+ A Sbjct: 658 SLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRAS 717 Query: 640 VMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLG 675 V+ + + K + + L + +E L YF +G Sbjct: 718 VLFANEKYKSALQELEELKQIVPKESL---VYFLIG 750 Score = 53.9 bits (128), Expect = 7e-07 Identities = 57/275 (20%), Positives = 115/275 (41%), Gaps = 28/275 (10%) Query: 428 WESEYTLFMSALK-----VNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGA 482 W + + +S L ++KN+ + W G+ ++ + A+K+F +A V P+ A Sbjct: 550 WHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYA 609 Query: 483 HMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE 542 + +G + T+E +++ ++ A R+ P H N + L +I + Sbjct: 610 YTLLGHEFV---LTEELDKALACFRN-----------AIRVNPRHYNAWYGL-GMIYYKQ 654 Query: 543 SRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYN 602 + A+ +++A+ + P G + + K KA + KA+ +D N ++ Sbjct: 655 EKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFH 714 Query: 603 LAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYIN 662 A V ++ AL+ ++ PK L F V ++ G+ L L+++ Sbjct: 715 RASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHL------ALMNFSW 768 Query: 663 EEPLDANGYFNLGMLAMDDK--KDNEAEIWMKKAI 695 LD G N A+D + D+E I ++ I Sbjct: 769 AMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQI 803 Score = 42.0 bits (97), Expect = 0.003 Identities = 32/141 (22%), Positives = 64/141 (45%), Gaps = 7/141 (4%) Query: 591 ELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLA--LFNSAIVMQESGEVK 648 ++D+N+ + W +E + A+K F RA++++P + A L V+ E + Sbjct: 567 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD-- 624 Query: 649 LRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708 +A + I P N ++ LGM+ +K + AE+ +KA+ + L ++ Sbjct: 625 ---KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 681 Query: 709 ALLYSQTAKELKALPILEELL 729 ++ K KAL L + + Sbjct: 682 GVVQHALKKSEKALDTLNKAI 702 Score = 40.4 bits (93), Expect = 0.008 Identities = 44/227 (19%), Positives = 86/227 (37%), Gaps = 38/227 (16%) Query: 548 ADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVH 607 A + +++AI + P++ AY G + + KA + A+ ++ + + WY L +++ Sbjct: 592 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 651 Query: 608 IELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLD 667 + ++ + A +F +AL++NP+ + L + +V Sbjct: 652 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHAL----------------------- 688 Query: 668 ANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEE 727 KK +A + KAI + F+ A + K AL LEE Sbjct: 689 --------------KKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEE 734 Query: 728 LLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGK 774 L + P L G + + L A F +++DP + Sbjct: 735 LKQIVPKESLVYFLIGKVYKKLGQTHL-ALMNFSWAMDLDPKGANNQ 780 Score = 32.3 bits (72), Expect = 2.1 Identities = 18/102 (17%), Positives = 47/102 (46%), Gaps = 3/102 (2%) Query: 721 ALPILEELLRYYPDHIKGLILKG-DILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCV 779 A+ + ++ P++ L G + ++ ++ D A CF + ++P + + L + Sbjct: 592 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD--KALACFRNAIRVNPRHYNAWYGLGM 649 Query: 780 VYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSS 821 +Y++++ AE + L + P + H+ +V+ + S Sbjct: 650 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 691 >gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapiens] Length = 824 Score = 55.5 bits (132), Expect = 2e-07 Identities = 41/156 (26%), Positives = 77/156 (49%), Gaps = 4/156 (2%) Query: 520 AARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKP 579 A ++ PN+ Y L + E L++A +R AI + P A+ G + K K Sbjct: 593 AIQVDPNYAYAYTLLGHEFVLTEE-LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKF 651 Query: 580 LKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639 A+ + KAL+++ ++ L ++ +V LK+ +AL N+A+ ++PK+ L F+ A Sbjct: 652 SLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRAS 711 Query: 640 VMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLG 675 V+ + + K + + L + +E L YF +G Sbjct: 712 VLFANEKYKSALQELEELKQIVPKESL---VYFLIG 744 Score = 53.9 bits (128), Expect = 7e-07 Identities = 57/275 (20%), Positives = 115/275 (41%), Gaps = 28/275 (10%) Query: 428 WESEYTLFMSALK-----VNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGA 482 W + + +S L ++KN+ + W G+ ++ + A+K+F +A V P+ A Sbjct: 544 WHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYA 603 Query: 483 HMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE 542 + +G + T+E +++ ++ A R+ P H N + L +I + Sbjct: 604 YTLLGHEFV---LTEELDKALACFRN-----------AIRVNPRHYNAWYGL-GMIYYKQ 648 Query: 543 SRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYN 602 + A+ +++A+ + P G + + K KA + KA+ +D N ++ Sbjct: 649 EKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFH 708 Query: 603 LAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYIN 662 A V ++ AL+ ++ PK L F V ++ G+ L L+++ Sbjct: 709 RASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHL------ALMNFSW 762 Query: 663 EEPLDANGYFNLGMLAMDDK--KDNEAEIWMKKAI 695 LD G N A+D + D+E I ++ I Sbjct: 763 AMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQI 797 Score = 42.0 bits (97), Expect = 0.003 Identities = 32/141 (22%), Positives = 64/141 (45%), Gaps = 7/141 (4%) Query: 591 ELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLA--LFNSAIVMQESGEVK 648 ++D+N+ + W +E + A+K F RA++++P + A L V+ E + Sbjct: 561 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD-- 618 Query: 649 LRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708 +A + I P N ++ LGM+ +K + AE+ +KA+ + L ++ Sbjct: 619 ---KALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675 Query: 709 ALLYSQTAKELKALPILEELL 729 ++ K KAL L + + Sbjct: 676 GVVQHALKKSEKALDTLNKAI 696 Score = 40.4 bits (93), Expect = 0.008 Identities = 44/227 (19%), Positives = 86/227 (37%), Gaps = 38/227 (16%) Query: 548 ADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVH 607 A + +++AI + P++ AY G + + KA + A+ ++ + + WY L +++ Sbjct: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 645 Query: 608 IELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLD 667 + ++ + A +F +AL++NP+ + L + +V Sbjct: 646 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHAL----------------------- 682 Query: 668 ANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEE 727 KK +A + KAI + F+ A + K AL LEE Sbjct: 683 --------------KKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEE 728 Query: 728 LLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGK 774 L + P L G + + L A F +++DP + Sbjct: 729 LKQIVPKESLVYFLIGKVYKKLGQTHL-ALMNFSWAMDLDPKGANNQ 774 Score = 32.3 bits (72), Expect = 2.1 Identities = 18/102 (17%), Positives = 47/102 (46%), Gaps = 3/102 (2%) Query: 721 ALPILEELLRYYPDHIKGLILKG-DILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCV 779 A+ + ++ P++ L G + ++ ++ D A CF + ++P + + L + Sbjct: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELD--KALACFRNAIRVNPRHYNAWYGLGM 643 Query: 780 VYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSS 821 +Y++++ AE + L + P + H+ +V+ + S Sbjct: 644 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 685 >gi|7661950 SH2 domain binding protein 1 [Homo sapiens] Length = 1173 Score = 52.0 bits (123), Expect = 3e-06 Identities = 103/498 (20%), Positives = 188/498 (37%), Gaps = 80/498 (16%) Query: 444 NNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHM------NVGRTYKNLNRTK 497 ++ + W + LE + + + AL + AT + + + A + NVG + L Sbjct: 410 DDVEAWIELAQILE-QTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLG 468 Query: 498 EAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLA------NLIRANESRLE--EAD 549 EA++ ++ + A+ H Y N NL R E+ E EA+ Sbjct: 469 EAKKYFLASLD-----------RAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAE 517 Query: 550 QLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIE 609 +LY+ + P++ Y+ G + +A + + +AL++++++ D W + +H+ Sbjct: 518 KLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLA 577 Query: 610 LKEPNEALKNFNRAL-----ELNPKHKLALFNSAIVMQESGEVKLRPEARKR-----LLS 659 +E K F R L + + LAL N + +Q + E KR L Sbjct: 578 KQEWGPGQKKFERILKQPSTQSDTYSMLALGN--VWLQTLHQPTRDREKEKRHQDRALAI 635 Query: 660 YINEEPLDANGYF---NLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTA 716 Y DA + +G + EA + + AD NLA +Y + Sbjct: 636 YKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQK 695 Query: 717 KELKALPILEELLRYYPDH--------IKGLILKGDILMNQKKDILGAKKCFERILEMDP 768 + + A+ + E LR + H + + K L K+ +L A+ + P Sbjct: 696 QYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKAR-------HVAP 748 Query: 769 SNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIF 828 S+ N+ +V L T L + ++ LN V++ + + Sbjct: 749 SDTVLMFNVALVLQR-----------LATSVLKDEKSNLKEVLNAVKELELAHRYF---- 793 Query: 829 PTSKISSVEGKKIPTESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTK 888 S +S V G K+ + T+ + SD SQ++ + + DEE K Sbjct: 794 --SYLSKV-GDKMRFDLA------LAATEARQCSDLLSQAQYHVARARKQDEEERELRAK 844 Query: 889 DIKEIEKKRVAALKRLEE 906 +E E R LK EE Sbjct: 845 QEQEKELLRQKLLKEQEE 862 Score = 48.1 bits (113), Expect = 4e-05 Identities = 56/274 (20%), Positives = 114/274 (41%), Gaps = 15/274 (5%) Query: 524 APNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFK-QAYISRGELLLKMNKPLKA 582 +PN++ + A I N+ A Y++A+ P + + G +K+NK KA Sbjct: 159 SPNNIPALLGKA-CISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKA 217 Query: 583 KEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN----FNRALELNPKHKLALFNSA 638 + A+ +ALEL+ LA++ + KE +++KN +RA ++P + + L + A Sbjct: 218 RLAFSRALELNSKCVGALVGLAVLELNNKEA-DSIKNGVQLLSRAYTIDPSNPMVLNHLA 276 Query: 639 IVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLG-MLAMDDKKDNEAEIWMKKAIKL 697 + E + A + L + + D + + + Sbjct: 277 NHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFA 336 Query: 698 QADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILM----NQKKDI 753 + F F L +Y + A E++L+ YP++ + + + G + +K+DI Sbjct: 337 SSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDI 396 Query: 754 LGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDL 787 AK +++ E P +V+ L + E+ D+ Sbjct: 397 --AKGHLKKVTEQYPDDVEAWIELAQI-LEQTDI 427 Score = 43.9 bits (102), Expect = 7e-04 Identities = 55/270 (20%), Positives = 114/270 (42%), Gaps = 23/270 (8%) Query: 434 LFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNL 493 L+ + L+ + N + +G ++ NF A +F +A + D A +G + Sbjct: 519 LYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAK 578 Query: 494 NRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEE-ADQLY 552 ++ + + L Y+ N ++ R E R ++ A +Y Sbjct: 579 QEWGPGQKKF--ERILKQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIY 636 Query: 553 RQAISMRPDFKQAYISRGELLLKMNKPL--KAKEAYLKALELDRNNADLWYNLAIVHIEL 610 +Q + R D K Y + G + +K +A++ + + E + +D+W NLA +++E Sbjct: 637 KQVL--RNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQ 694 Query: 611 KEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEV----KLRPEARKRLLSYINEEPL 666 K+ A++ + L KH+ N+ +V+ + + KL+ E ++ LL + P Sbjct: 695 KQYISAVQMYENCLRKFYKHQ----NTEVVLYLARALFKCGKLQ-ECKQTLLKARHVAPS 749 Query: 667 DANGYFNLGML-------AMDDKKDNEAEI 689 D FN+ ++ + D+K N E+ Sbjct: 750 DTVLMFNVALVLQRLATSVLKDEKSNLKEV 779 >gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sapiens] Length = 1347 Score = 51.2 bits (121), Expect = 4e-06 Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 26/215 (12%) Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQ- 476 F N D++S F AL +NA++ ++ H E ++ + A + + Q + Sbjct: 174 FKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEN 233 Query: 477 -PDDIGAHM--NVGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHL 528 P + A + +G + N++ TKE+ + KSL PN Sbjct: 234 LPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD------------PNSG 281 Query: 529 NVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLK 588 + L ++ ++++A YRQ+I + S G L + N+P+ A +AY+ Sbjct: 282 QSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340 Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623 A++LD +A W +L ++ +P +A+K + A Sbjct: 341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375 >gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo sapiens] Length = 1079 Score = 51.2 bits (121), Expect = 4e-06 Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 26/215 (12%) Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQ- 476 F N D++S F AL +NA++ ++ H E ++ + A + + Q + Sbjct: 174 FKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEN 233 Query: 477 -PDDIGAHM--NVGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHL 528 P + A + +G + N++ TKE+ + KSL PN Sbjct: 234 LPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD------------PNSG 281 Query: 529 NVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLK 588 + L ++ ++++A YRQ+I + S G L + N+P+ A +AY+ Sbjct: 282 QSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340 Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623 A++LD +A W +L ++ +P +A+K + A Sbjct: 341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375 >gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sapiens] Length = 1240 Score = 51.2 bits (121), Expect = 4e-06 Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 26/215 (12%) Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQ- 476 F N D++S F AL +NA++ ++ H E ++ + A + + Q + Sbjct: 174 FKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEN 233 Query: 477 -PDDIGAHM--NVGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHL 528 P + A + +G + N++ TKE+ + KSL PN Sbjct: 234 LPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEAD------------PNSG 281 Query: 529 NVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLK 588 + L ++ ++++A YRQ+I + S G L + N+P+ A +AY+ Sbjct: 282 QSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340 Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623 A++LD +A W +L ++ +P +A+K + A Sbjct: 341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375 >gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X chromosome [Homo sapiens] Length = 1401 Score = 50.4 bits (119), Expect = 7e-06 Identities = 49/217 (22%), Positives = 95/217 (43%), Gaps = 30/217 (13%) Query: 422 FHRNWDWESEYTLFMSAL----KVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQP 477 F N D+ES F AL +NA++ ++ H E ++ + A + + Q +Q Sbjct: 177 FKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQL--LQT 234 Query: 478 DDIGAHMN------VGRTYKNLN-----RTKEAEESYMMAKSLMPQIIPGKKYAARIAPN 526 +++ A + +G + ++ TKE+ + KSL PN Sbjct: 235 ENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEAD------------PN 282 Query: 527 HLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAY 586 + L ++ ++++A YRQ+I + S G L + N+P+ A +AY Sbjct: 283 SGQSWYFLGRCY-SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAY 341 Query: 587 LKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRA 623 + A++LD +A W +L ++ +P +A+K + A Sbjct: 342 ICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 378 >gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens] Length = 626 Score = 50.1 bits (118), Expect = 1e-05 Identities = 27/88 (30%), Positives = 45/88 (51%) Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481 FH + ++ F +AL V + LWN +G L N E A++ + +A +QP I Sbjct: 484 FHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIR 543 Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509 + N+G + NL +EA +++ A SL Sbjct: 544 SRYNLGISCINLGAYREAVSNFLTALSL 571 Score = 45.8 bits (107), Expect = 2e-04 Identities = 50/230 (21%), Positives = 92/230 (40%), Gaps = 32/230 (13%) Query: 434 LFM-SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKN 492 LFM +A+ + +A+ W +G +N + A+ + +QP+++ A M + +Y N Sbjct: 347 LFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTN 406 Query: 493 LNRTKEAEES---YMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEAD 549 ++A ++ ++ ++ KK + + ++ + L E LE A Sbjct: 407 TGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAH 466 Query: 550 Q----------------------------LYRQAISMRPDFKQAYISRGELLLKMNKPLK 581 Q + A+++RP+ + G L ++ + Sbjct: 467 QNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEE 526 Query: 582 AKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631 A EAY +ALE+ YNL I I L EA+ NF AL L K + Sbjct: 527 AVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSR 576 Score = 34.3 bits (77), Expect = 0.54 Identities = 18/75 (24%), Positives = 40/75 (53%) Query: 661 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK 720 I ++P DA + LG+ +++ + A + +++ ++LQ + AL LA+ Y+ T + Sbjct: 353 ILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQD 412 Query: 721 ALPILEELLRYYPDH 735 A L+ ++ P + Sbjct: 413 ACDALKNWIKQNPKY 427 Score = 31.6 bits (70), Expect = 3.5 Identities = 34/175 (19%), Positives = 66/175 (37%), Gaps = 23/175 (13%) Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486 +W + + +K K + L + + + E + +L+A H D I + Sbjct: 419 NWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQT 478 Query: 487 G-----RTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRAN 541 G NR +A + A + P +++ L + AN Sbjct: 479 GLGVLFHLSGEFNRAIDAFNA-----------------ALTVRPEDYSLWNRLGATL-AN 520 Query: 542 ESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNN 596 R EEA + Y +A+ ++P F ++ + G + + +A +L AL L R + Sbjct: 521 GDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKS 575 Score = 31.2 bits (69), Expect = 4.6 Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 3/77 (3%) Query: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVK 648 A+ D +A+ W L I E + A+ R LEL P + AL A+ +G Sbjct: 352 AILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGH-- 409 Query: 649 LRPEARKRLLSYINEEP 665 + +A L ++I + P Sbjct: 410 -QQDACDALKNWIKQNP 425 >gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo sapiens] Length = 639 Score = 48.5 bits (114), Expect = 3e-05 Identities = 26/88 (29%), Positives = 46/88 (52%) Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481 F+ + +++ F +AL V N+ LWN +G L N E A+ + +A +QP I Sbjct: 498 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 557 Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509 + N+G + NL +EA E ++ A ++ Sbjct: 558 SRYNLGISCINLGAHREAVEHFLEALNM 585 Score = 39.7 bits (91), Expect = 0.013 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%) Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578 A R+ P ++ + + N S ++A + A+S+RP+ + G L N+ Sbjct: 478 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 537 Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631 +A AY +ALEL YNL I I L EA+++F AL + K + Sbjct: 538 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 590 Score = 36.2 bits (82), Expect = 0.14 Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%) Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486 D + LF +A++ + + + W +G + A+ + ++PD+ A M + Sbjct: 350 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 409 Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540 ++ N + ++A E+ P + P ++ A A + P+ L +L+ Sbjct: 410 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 463 Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598 ++S E +L+ A+ + P G L + KA + + AL + N+ Sbjct: 464 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 523 Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639 LW L + EA+ + RALEL P + + +N I Sbjct: 524 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 564 >gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo sapiens] Length = 639 Score = 48.5 bits (114), Expect = 3e-05 Identities = 26/88 (29%), Positives = 46/88 (52%) Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481 F+ + +++ F +AL V N+ LWN +G L N E A+ + +A +QP I Sbjct: 498 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 557 Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509 + N+G + NL +EA E ++ A ++ Sbjct: 558 SRYNLGISCINLGAHREAVEHFLEALNM 585 Score = 39.7 bits (91), Expect = 0.013 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%) Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578 A R+ P ++ + + N S ++A + A+S+RP+ + G L N+ Sbjct: 478 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 537 Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631 +A AY +ALEL YNL I I L EA+++F AL + K + Sbjct: 538 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 590 Score = 36.2 bits (82), Expect = 0.14 Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%) Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486 D + LF +A++ + + + W +G + A+ + ++PD+ A M + Sbjct: 350 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 409 Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540 ++ N + ++A E+ P + P ++ A A + P+ L +L+ Sbjct: 410 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 463 Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598 ++S E +L+ A+ + P G L + KA + + AL + N+ Sbjct: 464 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 523 Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639 LW L + EA+ + RALEL P + + +N I Sbjct: 524 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 564 >gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo sapiens] Length = 602 Score = 48.5 bits (114), Expect = 3e-05 Identities = 26/88 (29%), Positives = 46/88 (52%) Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481 F+ + +++ F +AL V N+ LWN +G L N E A+ + +A +QP I Sbjct: 461 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 520 Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509 + N+G + NL +EA E ++ A ++ Sbjct: 521 SRYNLGISCINLGAHREAVEHFLEALNM 548 Score = 39.7 bits (91), Expect = 0.013 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%) Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578 A R+ P ++ + + N S ++A + A+S+RP+ + G L N+ Sbjct: 441 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 500 Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631 +A AY +ALEL YNL I I L EA+++F AL + K + Sbjct: 501 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 553 Score = 36.2 bits (82), Expect = 0.14 Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%) Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486 D + LF +A++ + + + W +G + A+ + ++PD+ A M + Sbjct: 313 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 372 Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540 ++ N + ++A E+ P + P ++ A A + P+ L +L+ Sbjct: 373 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 426 Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598 ++S E +L+ A+ + P G L + KA + + AL + N+ Sbjct: 427 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 486 Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639 LW L + EA+ + RALEL P + + +N I Sbjct: 487 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 527 >gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo sapiens] Length = 654 Score = 48.5 bits (114), Expect = 3e-05 Identities = 26/88 (29%), Positives = 46/88 (52%) Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481 F+ + +++ F +AL V N+ LWN +G L N E A+ + +A +QP I Sbjct: 513 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 572 Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509 + N+G + NL +EA E ++ A ++ Sbjct: 573 SRYNLGISCINLGAHREAVEHFLEALNM 600 Score = 39.7 bits (91), Expect = 0.013 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%) Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578 A R+ P ++ + + N S ++A + A+S+RP+ + G L N+ Sbjct: 493 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 552 Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631 +A AY +ALEL YNL I I L EA+++F AL + K + Sbjct: 553 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 605 Score = 36.2 bits (82), Expect = 0.14 Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%) Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486 D + LF +A++ + + + W +G + A+ + ++PD+ A M + Sbjct: 365 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 424 Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540 ++ N + ++A E+ P + P ++ A A + P+ L +L+ Sbjct: 425 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 478 Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598 ++S E +L+ A+ + P G L + KA + + AL + N+ Sbjct: 479 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 538 Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639 LW L + EA+ + RALEL P + + +N I Sbjct: 539 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 579 >gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo sapiens] Length = 631 Score = 48.5 bits (114), Expect = 3e-05 Identities = 26/88 (29%), Positives = 46/88 (52%) Query: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481 F+ + +++ F +AL V N+ LWN +G L N E A+ + +A +QP I Sbjct: 490 FNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIR 549 Query: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509 + N+G + NL +EA E ++ A ++ Sbjct: 550 SRYNLGISCINLGAHREAVEHFLEALNM 577 Score = 39.7 bits (91), Expect = 0.013 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 1/113 (0%) Query: 520 AARIAPNHLNVYINLANLIRANES-RLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578 A R+ P ++ + + N S ++A + A+S+RP+ + G L N+ Sbjct: 470 AVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQ 529 Query: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631 +A AY +ALEL YNL I I L EA+++F AL + K + Sbjct: 530 SEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSR 582 Score = 36.2 bits (82), Expect = 0.14 Identities = 46/221 (20%), Positives = 91/221 (41%), Gaps = 14/221 (6%) Query: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486 D + LF +A++ + + + W +G + A+ + ++PD+ A M + Sbjct: 342 DLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMAL 401 Query: 487 GRTYKNLNRTKEAEESYMMAKSLMPQ----IIPGKKYA--ARIAPNHLNVYINLANLIRA 540 ++ N + ++A E+ P + P ++ A A + P+ L +L+ Sbjct: 402 AVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRI----LGSLL-- 455 Query: 541 NESRLEEADQLYRQAISMRPDF--KQAYISRGELLLKMNKPLKAKEAYLKALELDRNNAD 598 ++S E +L+ A+ + P G L + KA + + AL + N+ Sbjct: 456 SDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYL 515 Query: 599 LWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639 LW L + EA+ + RALEL P + + +N I Sbjct: 516 LWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 556 >gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo sapiens] Length = 860 Score = 47.4 bits (111), Expect = 6e-05 Identities = 46/201 (22%), Positives = 82/201 (40%), Gaps = 24/201 (11%) Query: 456 LENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIP 515 L + KN E AL + ++PD L R EA A L P Sbjct: 192 LHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPS--- 248 Query: 516 GKKYAAR-----IAPNHLNVYINLANLIRANESR----------------LEEADQLYRQ 554 + Y R I+ ++ + + + N+++ L+EA + +++ Sbjct: 249 ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKE 308 Query: 555 AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614 A+ + DF AY S G+ ++ A E++ KAL L++N+ ++ Sbjct: 309 ALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQ 368 Query: 615 EALKNFNRALELNPKHKLALF 635 EALKNF R L+L P +++ + Sbjct: 369 EALKNFKRCLQLEPYNEVCQY 389 Score = 44.3 bits (103), Expect = 5e-04 Identities = 45/217 (20%), Positives = 93/217 (42%), Gaps = 39/217 (17%) Query: 554 QAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEP 613 + I++ PD + + R E+L + + +A KA++L + +A L+ + ++ ++ Sbjct: 207 RVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQL-QPSARLYRHRGTLYFISEDY 265 Query: 614 NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFN 673 A ++F ++LELN +A+ + +F+ Sbjct: 266 ATAHEDFQQSLELNKNQPIAMLYKGLT------------------------------FFH 295 Query: 674 LGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYP 733 G+L EA K+A+K + DF A +L Y + A ++ L Sbjct: 296 RGLL-------KEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 348 Query: 734 DHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSN 770 +H++ L L+G +++ + A K F+R L+++P N Sbjct: 349 NHVQTLQLRG-MMLYHHGSLQEALKNFKRCLQLEPYN 384 >gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sapiens] Length = 515 Score = 47.0 bits (110), Expect = 8e-05 Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%) Query: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524 AL F Q P ++ + R Y+ +N A E Y K ++ Q + A I Sbjct: 277 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 333 Query: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584 NH + E A + YR+ + M Q + + G + Sbjct: 334 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 381 Query: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641 ++ +AL L N AD+WYNL V + + + N A + F AL N H A N A++ Sbjct: 382 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 441 Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678 G V+ +AR L + + P +FN ++ Sbjct: 442 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 475 Score = 45.4 bits (106), Expect = 2e-04 Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%) Query: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529 L H Q D + +G+ Y L +EAE+ + A +++ Y A+ Sbjct: 215 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 266 Query: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589 VY++L + A L++Q + P + +MN A E Y + Sbjct: 267 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 318 Query: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649 L+ D + + + H +P AL+ + R L++ + N + + + + Sbjct: 319 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 378 Query: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709 + +R LS E A+ ++NLG +A+ N A + A+ + A NLA Sbjct: 379 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 438 Query: 710 LLYSQTAKELKALPILE 726 +L + +A +L+ Sbjct: 439 VLEMRKGHVEQARALLQ 455 >gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sapiens] Length = 475 Score = 47.0 bits (110), Expect = 8e-05 Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%) Query: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524 AL F Q P ++ + R Y+ +N A E Y K ++ Q + A I Sbjct: 237 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 293 Query: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584 NH + E A + YR+ + M Q + + G + Sbjct: 294 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 341 Query: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641 ++ +AL L N AD+WYNL V + + + N A + F AL N H A N A++ Sbjct: 342 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 401 Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678 G V+ +AR L + + P +FN ++ Sbjct: 402 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 435 Score = 45.4 bits (106), Expect = 2e-04 Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%) Query: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529 L H Q D + +G+ Y L +EAE+ + A +++ Y A+ Sbjct: 175 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 226 Query: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589 VY++L + A L++Q + P + +MN A E Y + Sbjct: 227 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 278 Query: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649 L+ D + + + H +P AL+ + R L++ + N + + + + Sbjct: 279 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 338 Query: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709 + +R LS E A+ ++NLG +A+ N A + A+ + A NLA Sbjct: 339 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 398 Query: 710 LLYSQTAKELKALPILE 726 +L + +A +L+ Sbjct: 399 VLEMRKGHVEQARALLQ 415 >gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sapiens] Length = 505 Score = 47.0 bits (110), Expect = 8e-05 Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 21/217 (9%) Query: 465 ALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIA 524 AL F Q P ++ + R Y+ +N A E Y K ++ Q + A I Sbjct: 267 ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYY---KEVLKQDNTHVEAIACIG 323 Query: 525 PNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKE 584 NH + E A + YR+ + M Q + + G + Sbjct: 324 SNHFY------------SDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLT 371 Query: 585 AYLKALELDRNN---ADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVM 641 ++ +AL L N AD+WYNL V + + + N A + F AL N H A N A++ Sbjct: 372 SFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLE 431 Query: 642 QESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLA 678 G V+ +AR L + + P +FN ++ Sbjct: 432 MRKGHVE---QARALLQTASSLAPHMYEPHFNFATIS 465 Score = 45.4 bits (106), Expect = 2e-04 Identities = 53/257 (20%), Positives = 101/257 (39%), Gaps = 16/257 (6%) Query: 470 LQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLN 529 L H Q D + +G+ Y L +EAE+ + A +++ Y A+ Sbjct: 205 LSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAK------- 256 Query: 530 VYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKA 589 VY++L + A L++Q + P + +MN A E Y + Sbjct: 257 VYVSLDQPVTALN--------LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV 308 Query: 590 LELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKL 649 L+ D + + + H +P AL+ + R L++ + N + + + + Sbjct: 309 LKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDM 368 Query: 650 RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLA 709 + +R LS E A+ ++NLG +A+ N A + A+ + A NLA Sbjct: 369 TLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 428 Query: 710 LLYSQTAKELKALPILE 726 +L + +A +L+ Sbjct: 429 VLEMRKGHVEQARALLQ 445 >gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo sapiens] Length = 807 Score = 47.0 bits (110), Expect = 8e-05 Identities = 27/91 (29%), Positives = 49/91 (53%) Query: 545 LEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLA 604 L+EA + +++A+ + DF AY S G+ ++ A E++ KAL L++N+ Sbjct: 246 LKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRG 305 Query: 605 IVHIELKEPNEALKNFNRALELNPKHKLALF 635 ++ EALKNF R L+L P +++ + Sbjct: 306 MMLYHHGSLQEALKNFKRCLQLEPYNEVCQY 336 Score = 38.9 bits (89), Expect = 0.022 Identities = 49/222 (22%), Positives = 94/222 (42%), Gaps = 31/222 (13%) Query: 571 ELLLKMNKPLKAKEAYLKALELDRNNADL----------WYNLAIVH----IELKEP--- 613 E +L K + ++ + A + D N +L Y+ AI H +++ P Sbjct: 119 EKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGR 178 Query: 614 -NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPL----DA 668 NEA+ + +A++L P +L + S + E ++ L +P+ Sbjct: 179 INEAVNDLTKAIQLQPSARLYRHRGTLYFI-SEDYATAHEDFQQSLELNKNQPIAMLYKG 237 Query: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728 +F+ G+L EA K+A+K + DF A +L Y + A ++ Sbjct: 238 LTFFHRGLL-------KEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290 Query: 729 LRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSN 770 L +H++ L L+G +++ + A K F+R L+++P N Sbjct: 291 LLLNQNHVQTLQLRG-MMLYHHGSLQEALKNFKRCLQLEPYN 331 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.136 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 31,403,484 Number of Sequences: 37866 Number of extensions: 1338340 Number of successful extensions: 4684 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 81 Number of HSP's successfully gapped in prelim test: 75 Number of HSP's that attempted gapping in prelim test: 3899 Number of HSP's gapped (non-prelim): 565 length of query: 914 length of database: 18,247,518 effective HSP length: 111 effective length of query: 803 effective length of database: 14,044,392 effective search space: 11277646776 effective search space used: 11277646776 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.