Search of human proteins with 115511012

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
         (1154 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|115511012 coiled-coil domain containing 136 [Homo sapiens]        2251   0.0  
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   147   7e-35
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   145   2e-34
gi|148746195 trichohyalin [Homo sapiens]                              145   2e-34
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   145   2e-34
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   145   2e-34
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   145   2e-34
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   145   2e-34
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    143   1e-33
gi|71061468 centromere protein E [Homo sapiens]                       142   2e-33
gi|21735548 centrosomal protein 2 [Homo sapiens]                      140   9e-33
gi|56550043 sarcolemma associated protein [Homo sapiens]              134   7e-31
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       132   2e-30
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       132   2e-30
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        132   2e-30
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        132   2e-30
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        132   2e-30
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        132   2e-30
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        132   2e-30
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        132   2e-30
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        129   1e-29
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            127   6e-29
gi|221219020 NYD-SP11 protein [Homo sapiens]                          127   8e-29
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   126   1e-28
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   125   3e-28
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    123   1e-27
gi|55770834 centromere protein F [Homo sapiens]                       122   2e-27
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   122   2e-27
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   122   3e-27
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]   122   3e-27

>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
          Length = 1154

 Score = 2251 bits (5834), Expect = 0.0
 Identities = 1154/1154 (100%), Positives = 1154/1154 (100%)

Query: 1    MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE 60
            MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE
Sbjct: 1    MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE 60

Query: 61   LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS 120
            LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS
Sbjct: 61   LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS 120

Query: 121  LREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN 180
            LREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN
Sbjct: 121  LREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN 180

Query: 181  ELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEY 240
            ELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEY
Sbjct: 181  ELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEY 240

Query: 241  RALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLR 300
            RALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLR
Sbjct: 241  RALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLR 300

Query: 301  QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS 360
            QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS
Sbjct: 301  QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS 360

Query: 361  VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC 420
            VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC
Sbjct: 361  VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC 420

Query: 421  RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQ 480
            RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQ
Sbjct: 421  RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQ 480

Query: 481  LQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL 540
            LQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL
Sbjct: 481  LQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL 540

Query: 541  SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK 600
            SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK
Sbjct: 541  SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK 600

Query: 601  SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLEN 660
            SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLEN
Sbjct: 601  SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLEN 660

Query: 661  PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADL 720
            PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADL
Sbjct: 661  PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADL 720

Query: 721  QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ 780
            QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ
Sbjct: 721  QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ 780

Query: 781  TSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP 840
            TSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP
Sbjct: 781  TSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP 840

Query: 841  AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER 900
            AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER
Sbjct: 841  AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER 900

Query: 901  EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC 960
            EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC
Sbjct: 901  EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC 960

Query: 961  QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVV 1020
            QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVV
Sbjct: 961  QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVV 1020

Query: 1021 LYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEE 1080
            LYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEE
Sbjct: 1021 LYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEE 1080

Query: 1081 NEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVV 1140
            NEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVV
Sbjct: 1081 NEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVV 1140

Query: 1141 ISALLWCWWAETSS 1154
            ISALLWCWWAETSS
Sbjct: 1141 ISALLWCWWAETSS 1154


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  147 bits (370), Expect = 7e-35
 Identities = 243/1139 (21%), Positives = 494/1139 (43%), Gaps = 169/1139 (14%)

Query: 51   LSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQ---QAEVF 107
            L +T  E EEL+A+  +L+   E+  ++ G+ E+   + Q LLE++ + + Q   + E+F
Sbjct: 845  LQVTRQE-EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903

Query: 108  TKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESD 167
              + ++++  L + ++E+  + H+ ES ++E E+   +                      
Sbjct: 904  A-EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI---------------------- 940

Query: 168  IASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQ 227
               LQ +  +MQ  ++D+E      E E A  + ++E  ++E       +    ++EE+ 
Sbjct: 941  ---LQNEKKKMQAHIQDLEEQLD--EEEGARQKLQLEKVTAE-------AKIKKMEEEIL 988

Query: 228  ELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEM 287
             L ++     +E + +++  +  + QLA+ E +    A  R  Q   +S           
Sbjct: 989  LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS----------- 1037

Query: 288  DFLEPDPEMQLLRQQLRDAEEQMHG----MKNKCQELCCELEELQHHRQVSEEEQRRLQR 343
            D  E   + +  RQ+L  A+ ++ G    ++++  EL  +++EL+      EEE   LQ 
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE---LQG 1094

Query: 344  ELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLK 403
             L    +E L    +  V +  EL++++  LQ+ +++ +  +N+  K +  L  EL  LK
Sbjct: 1095 ALARGDDETLHKNNALKVVR--ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALK 1152

Query: 404  V-MKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRD 462
              ++ TL    +++EL              T  ++++ E ++ L+EE + HEA++Q +R 
Sbjct: 1153 TELEDTLDTTAAQQELR-------------TKREQEVAELKKALEEETKNHEAQIQDMRQ 1199

Query: 463  TVAS----FKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQD------LLLC 512
              A+      E  E+     A L++ KQ  +    EL  +  +  Q++ +       L  
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259

Query: 513  QLELKELKASH------PIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQ---ME 563
            Q++    K S        + E   K  N+ D + + L E ++K     K+   L+    +
Sbjct: 1260 QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD 1319

Query: 564  QCELLEDQ-----------RRMQEEQGQL---QEELHRLTLPLPKSGLLLKSQELLTKLE 609
              ELL+++           R+++EE+  L   QEE       L K  L L+SQ   TK +
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK 1379

Query: 610  DLCELQLLYQGMQEEQKKLIQNQDCV---LKEQLEIHEELRRFKESHFQEVLENPDDSKL 666
               +L  + + ++E +KKL+++ + +   L+E+   +++L + K    QE+ +   D   
Sbjct: 1380 VDDDLGTI-ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438

Query: 667  AKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERK-RLQADLQLCLE 725
             +    N  K+ K   +Q+ A +    A  A++    + + R  E +   L   L+  LE
Sbjct: 1439 QRQVASNLEKKQK-KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALE 1497

Query: 726  EMQLLQVQSPSIKMSLESYGKS---YGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTS 782
              +  + Q+  ++  +E    S    G  V   E  ++  +  V++  +  +       +
Sbjct: 1498 AKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQA 1557

Query: 783  SKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKK--------SYGSTSSSDTCQKSFVSS 834
            ++      + +  A +A  +    T +     KK           +    +  Q++   +
Sbjct: 1558 TEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVA 1617

Query: 835  CTDEEPAEPEDME-------RFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAK 887
               +   + +D+E       +  + V+K L KLQA    YQ   EE    +   +++ A+
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEE---ARASRDEIFAQ 1674

Query: 888  QKDLKEELDACEREFKECMECL-EKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRL 946
             K+ +++L + E E  +  E L     A ++ + E  EL  ++        A +DE+ RL
Sbjct: 1675 SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRL 1734

Query: 947  LVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDT 1006
                 QLE +L+  Q  +  L ++      +    NA     ++A            SD 
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA---------AQKSDN 1785

Query: 1007 SESDLETRKSLEVVLYYKASQRKLDGLAKEEEK------KEEMEEEKKQVKEEAKEQ-CG 1059
            +   LE R++ E+    KA  ++L+G  K + K      + ++ + ++Q+++EAKE+   
Sbjct: 1786 ARQQLE-RQNKEL----KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840

Query: 1060 DELV--AEPADPEEAKSTEDQEEN-EEDKEEEEKE-----------EDSEEEEDDADSS 1104
            ++LV   E    E     ED+  + ++ KE+ EK            E++EEE   A++S
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899



 Score =  136 bits (343), Expect = 1e-31
 Identities = 229/1106 (20%), Positives = 468/1106 (42%), Gaps = 178/1106 (16%)

Query: 9    LLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLS----------LTETEL 58
            LL    +EEE + ++EE ++ +E+Q +  G +  +   KH+ L             ETEL
Sbjct: 844  LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEME-RKHQQLLEEKNILAEQLQAETEL 902

Query: 59   ----EELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQL 114
                EE+RA++     ELEE         ++  E   +L++E+       +   +Q+ + 
Sbjct: 903  FAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962

Query: 115  QG--------------ELRSLREEISLLEHEKESELKE---IEQELHLAQAEIQSLRQAA 157
            +G              +++ + EEI LLE +    +KE   +E  +    +++    + A
Sbjct: 963  EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022

Query: 158  EDSA---TEHESDIASLQEDLCRMQNELEDMERIR-------GDYEMEIASLRAEME--- 204
            ++ A    + E  I+ L+E L + +   +++E+ +        D + +IA L+A+++   
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082

Query: 205  ----MKSSEPSGSLGLSDYSGLQEE-----LQELRERYHFLNEEYRALQESNSSLTGQLA 255
                 K  E  G+L   D   L +      ++EL+ +   L E++ + + S +    Q  
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142

Query: 256  DLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKN 315
            DL  E     TE      TL  T+A+ +       E     + L ++ ++ E Q+  M+ 
Sbjct: 1143 DLSEELEALKTE---LEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199

Query: 316  K----CQELCCELEELQHHRQVSEEEQRRLQ---RELKCAQNEVLRFQTSHSVTQNEELK 368
            +     +EL  +LE+ +  +   E+ ++ L+   +EL C + +VL+   + S  + ++L 
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC-EVKVLQQVKAESEHKRKKLD 1258

Query: 369  SRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVEN---------------- 412
            +++  L  K       + EL +   +LQ EL  +    STL+E                 
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNV----STLLEEAEKKGIKFAKDAASLE 1314

Query: 413  ---QSEKELLCR--LQKLHLQHQNVTCEKEK--LLERQQQLQEELQCHEAELQHLRDTVA 465
               Q  +ELL     QKL+L  +    E+EK  L E+Q++ +E  +  E ++  L+  +A
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374

Query: 466  SFKESNEKDTETHAQLQEMKQLY----QASKDELERQKHMYDQLEQDLLLCQLELKELKA 521
              K+  + D  T   L+E K+      +A    LE +   YD+LE+     Q EL +L  
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434

Query: 522  ----SHPIPEDKGKCANKCDTLLSRLTELQEKY---------KASQKEMGQLQMEQC--E 566
                   +  +  K   K D LL+    +  +Y         +A +KE   L + +   E
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1494

Query: 567  LLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQL--LYQGMQEE 624
             LE +   + +  QL+ ++  L       G   K+   L K +   E Q+  +   ++E 
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVG---KNVHELEKSKRALEQQVEEMRTQLEEL 1551

Query: 625  QKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQ 684
            + +L   +D  L+  LE++ +  +   + F+  L+  D+            ++ +LL++Q
Sbjct: 1552 EDELQATEDAKLR--LEVNMQAMK---AQFERDLQTRDE---------QNEEKKRLLIKQ 1597

Query: 685  MQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLC-------LEEMQLLQVQSPSI 737
            ++ L+   +  + ++ L    + ++  + K L+A ++         +++++ LQ Q    
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657

Query: 738  KMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYD--SSTS 795
            +  LE    S   +   ++   K   +   +     +   S++ + +   +  D  +   
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717

Query: 796  ASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDME----RFEE 851
             + A GKS        +                ++ ++   +E   E  +ME    RF +
Sbjct: 1718 TNSASGKSALLDEKRRL----------------EARIAQLEEELEEEQSNMELLNDRFRK 1761

Query: 852  MVVKV---LIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDL--------KEELDACER 900
              ++V     +L A ++  Q S     QL+ Q ++L AK ++L        K  + A E 
Sbjct: 1762 TTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEA 1821

Query: 901  EFKECMECLEKPMAPQNDKNE-IKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQC 959
            +  +  E LE+    +   N+ ++  + KL+E+ +Q +   DE+       +Q + Q++ 
Sbjct: 1822 KIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE---DERRH----ADQYKEQMEK 1874

Query: 960  CQEELRQLREKRPSVVKEARGKNANK 985
                ++QL+ +     +EA   NA++
Sbjct: 1875 ANARMKQLKRQLEEAEEEATRANASR 1900



 Score =  125 bits (315), Expect = 2e-28
 Identities = 198/946 (20%), Positives = 403/946 (42%), Gaps = 91/946 (9%)

Query: 7    EVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQV- 65
            EV++  L E  ++EE+  +E+E+ + ++   G    L           + ++ EL+AQ+ 
Sbjct: 1033 EVMISDLEERLKKEEKTRQELEKAKRKLD--GETTDL-----------QDQIAELQAQID 1079

Query: 66   ---LQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEV---FTKQ---IQQLQG 116
               LQL  + EE +    + +D++L     L+  R   AQ AE+   F  +     + + 
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK 1139

Query: 117  ELRSLREEISLLEHEKESEL--KEIEQELHL-AQAEIQSLRQAAEDSATEHESDIASLQE 173
            + R L EE+  L+ E E  L     +QEL    + E+  L++A E+    HE+ I  +++
Sbjct: 1140 QKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199

Query: 174  ----DLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQEL 229
                 L  +  +LE  +R + + E     L  + +  + E      +     ++ E +  
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE------VKVLQQVKAESEHK 1253

Query: 230  RERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDF 289
            R++     +E  A       L  +LA+  S+         LQ++ L   S   + +E   
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASK---------LQNE-LDNVSTLLEEAEKKG 1303

Query: 290  LEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQ 349
            ++   +   L  QL+D +E +     +   L   + +L+  +   +E+Q   +   K  +
Sbjct: 1304 IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363

Query: 350  NEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK--MQLQLQTELRQLKVMKS 407
             +VL  Q+  + T+ +++   L T+    ++ ++ + +LLK    L  + E + L   K 
Sbjct: 1364 KQVLALQSQLADTK-KKVDDDLGTI----ESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418

Query: 408  TLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASF 467
               +N+ ++EL      L  Q Q V    EK  ++  QL  E +   A     RD   + 
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQ-VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA- 1476

Query: 468  KESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPE 527
             E+ EK+T+  +  + +++  +A K+E ERQ        +DL+  + ++   K  H + +
Sbjct: 1477 -EAREKETKALSLARALEEALEA-KEEFERQNKQLRADMEDLMSSKDDVG--KNVHELEK 1532

Query: 528  DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHR 587
             K     + + + ++L EL+++ +A++    +L++    +     R  + + +  EE  R
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKR 1592

Query: 588  LTLPLPKSGLLLKSQELLTKLEDLCELQLL----YQGMQEEQKKLIQNQDCVLKEQLEIH 643
            L        L+ + +EL  +LED  + + L     + M+ + K L    +   K + E+ 
Sbjct: 1593 L--------LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVI 1644

Query: 644  EELRRFKE--SHFQEVLENPDDSK--LAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQ 699
            ++LR+ +     +Q  LE    S+  +   SK +  K   L  E +Q  + +  + +A++
Sbjct: 1645 KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARR 1704

Query: 700  ELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCR 759
               +QE+  L +E     +     L+E + L+ +   ++  LE   +   +M   N+  R
Sbjct: 1705 H-AEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELE---EEQSNMELLNDRFR 1760

Query: 760  KTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSY-CTTSNSSITYKKSY 818
            KT    VD       +  +   + +S  +  D++    E   K             K  +
Sbjct: 1761 KT-TLQVD-------TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF 1812

Query: 819  GSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQ 878
             +T S+    ++ +    ++   E ++     ++V +   KL+ +    +  +    Q +
Sbjct: 1813 KATISA---LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYK 1869

Query: 879  EQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKE 924
            EQMEK  A+ K LK +L+  E E         K     +D  E  E
Sbjct: 1870 EQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANE 1915



 Score =  105 bits (262), Expect = 2e-22
 Identities = 171/853 (20%), Positives = 368/853 (43%), Gaps = 106/853 (12%)

Query: 22   EEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQ 81
            E + ++ E +E  +   +  + +  + R LS    ELE L+ ++   +      +EL  +
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLS---EELEALKTELEDTLDTTAAQQELRTK 1171

Query: 82   HEDDSLELQGLLEDE-----------RLASAQQAEVFTKQIQQ--------------LQG 116
             E +  EL+  LE+E           R   A   E  ++Q++Q              L+ 
Sbjct: 1172 REQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET 1231

Query: 117  ELRSLREEISLLEH---EKESELKEIE---QELHLAQAEIQSLRQAAEDSATEHESDIAS 170
            + + L  E+ +L+    E E + K+++   QELH   +E   LR    + A++       
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASK------- 1284

Query: 171  LQEDLCRMQNELEDMERIRGDYEMEIASLRAEM----EMKSSEPSGSLGLSDYSGLQEEL 226
            LQ +L  +   LE+ E+    +  + ASL +++    E+   E    L LS        +
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS------SRI 1338

Query: 227  QELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSE 286
            ++L E  + L E+    +E+  +L  Q+  L+S+     T++ +     ++ S E    +
Sbjct: 1339 RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLAD--TKKKVDDDLGTIESLEEAKKK 1396

Query: 287  MDFLEPDPEMQLLRQQLRD---AEEQMHGMKNKCQELCCELE-ELQHHRQVS---EEEQR 339
            +       + + L Q+L +   A +++   KN+ Q+   +L  +L H RQV+   E++Q+
Sbjct: 1397 L-----LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQK 1451

Query: 340  RLQRELKCAQNEVLRF--QTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQT 397
            +  + L   ++   R+  +   +  +  E +++  +L +  + + + + E  +   QL+ 
Sbjct: 1452 KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA 1511

Query: 398  ELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAEL 457
            ++  L   K  + +N  E E      K  L+ Q      E++  + ++L++ELQ  E   
Sbjct: 1512 DMEDLMSSKDDVGKNVHELE----KSKRALEQQ-----VEEMRTQLEELEDELQATEDAK 1562

Query: 458  QHLRDTVASFKESNEKDTETH-AQLQEMKQLYQASKDELERQKHMYDQLEQDLLL----- 511
              L   + + K   E+D +T   Q +E K+L      ELE +  + D+ +Q  L      
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE--LEDERKQRALAVASKK 1620

Query: 512  -CQLELKELKASHPIPEDKGKCANKC-DTLLSRLTELQEKYKASQKEMGQLQMEQCELLE 569
              +++LK+L+A       + + ANK  D ++ +L +LQ + K  Q+E+ + +  + E+  
Sbjct: 1621 KMEIDLKDLEA-------QIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673

Query: 570  DQRRMQEEQGQLQEELHRLTLPLPKSGLLLK-SQELLTKLEDLCELQLLYQGMQEEQKKL 628
              +  +++   L+ E+ +L   L  S    + +++   +L D        +    ++K+ 
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733

Query: 629  IQNQDCVLKEQLEIHE---EL--RRFKESHFQ------EVLENPDDSKLAKSSKCNRNKQ 677
            ++ +   L+E+LE  +   EL   RF+++  Q      E+      ++ + +++    +Q
Sbjct: 1734 LEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQ 1793

Query: 678  SKLLMEQMQALQ-VMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPS 736
            +K L  ++Q L+  +    +A    L+ + G+L E+ ++   +     + ++  + +   
Sbjct: 1794 NKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKE 1853

Query: 737  IKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSA 796
            I M +E   +         E             E   +  T    S +   +  D +T A
Sbjct: 1854 IFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEA 1913

Query: 797  SEAYGKSYCTTSN 809
            +E   +   T  N
Sbjct: 1914 NEGLSREVSTLKN 1926



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 99/449 (22%), Positives = 190/449 (42%), Gaps = 69/449 (15%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKG-----GSVGSLSVNKH---RGLSL 53
            +A E E    +L    EE  E +EE E + +Q++        S   +  N H   +    
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536

Query: 54   TETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAE----VFTK 109
             E ++EE+R Q+ +L  EL+ T +   + E +   ++   E +     +Q E    +  K
Sbjct: 1537 LEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK 1596

Query: 110  QIQQLQGELRSLREEISLLEHEK---ESELKEIEQELHLA-------------------- 146
            Q+++L+ EL   R++ +L    K   E +LK++E ++  A                    
Sbjct: 1597 QVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD 1656

Query: 147  -QAEIQSLRQAAED---SATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAE 202
             Q E++  R + ++    + E E  + SL+ ++ ++Q EL   ER R   E E   L  E
Sbjct: 1657 YQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADE 1716

Query: 203  MEMKSSEPSGSLG-----LSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADL 257
            +   +S  S  L       +  + L+EEL+E +     LN+ +R       +L  +LA  
Sbjct: 1717 ITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA-- 1774

Query: 258  ESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDA-----EEQMHG 312
             +ER+                + +S  +       + E++   Q+L  A     +  +  
Sbjct: 1775 -AERS---------------AAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1818

Query: 313  MKNKCQELCCELEELQHHRQVSEEEQRRLQRELK--CAQNEVLRFQTSHSVTQNEELKSR 370
            ++ K  +L  +LE+    R  + +  RR +++LK    Q E  R        Q E+  +R
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR 1878

Query: 371  LCTLQKKYDTSQDEQNELLKMQLQLQTEL 399
            +  L+++ + +++E       + +LQ EL
Sbjct: 1879 MKQLKRQLEEAEEEATRANASRRKLQREL 1907



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 115/607 (18%), Positives = 251/607 (41%), Gaps = 97/607 (15%)

Query: 540  LSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLL 599
            L ++T  +E+ +A  +E+ +++ +Q ++  +   M+ +  QL EE + L   L     L 
Sbjct: 844  LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903

Query: 600  KSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFK---ESHFQE 656
               E         E++      ++E ++++ + +  ++E+ E ++ L+  K   ++H Q+
Sbjct: 904  AEAE---------EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954

Query: 657  VLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQE----LLQQEQGRLLEE 712
            + E  D+ + A+          KL +E++ A     +A   K E    LL+ +  + ++E
Sbjct: 955  LEEQLDEEEGARQ---------KLQLEKVTA-----EAKIKKMEEEILLLEDQNSKFIKE 1000

Query: 713  RKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESY 772
            +K ++  +  C  ++   + ++ ++                     R   +  + D E  
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLA------------------KIRNKQEVMISDLEER 1042

Query: 773  YKSYTSTQTSSKSFLKSYDSSTS-ASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSF 831
             K    T+   +   +  D  T+   +   +         +   K       +       
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGA------- 1095

Query: 832  VSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDL 891
                     A  +D    +   +KV+ +LQA  A  Q   E     + + EK   +++DL
Sbjct: 1096 --------LARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK---QKRDL 1144

Query: 892  KEELDACEREFKECMECLEKPMAPQNDKN-EIKELQTKLRELQLQYQASMDEQGRLLVVQ 950
             EEL+A + E ++ ++        +  +  E+ EL+  L E    ++A + +      ++
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD------MR 1198

Query: 951  EQLEGQLQCCQEELRQLREKRPSVVKEARG-KNANKNMNKNANGVKMKKVTKPCSDTSES 1009
            ++    L+   E+L Q +  + ++ K  +G +  NK +   A  VK+ +  K  S+    
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL---ACEVKVLQQVKAESEHKRK 1255

Query: 1010 DLETRKS-----------LEVVLYYKAS--QRKLDGLAK--EEEKKEEMEEEKKQVKEEA 1054
             L+ +             L V L  KAS  Q +LD ++   EE +K+ ++  K     E+
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315

Query: 1055 KEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPL 1114
            + Q   EL+ E    E  +         + +EE+   ++ +EEE++A  +LE        
Sbjct: 1316 QLQDTQELLQE----ETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371

Query: 1115 RLSESKK 1121
            +L+++KK
Sbjct: 1372 QLADTKK 1378



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 34/121 (28%), Positives = 55/121 (45%), Gaps = 15/121 (12%)

Query: 1001 KPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGD 1060
            KP    +  + E +   E +L  K  Q K++G  +E E+K +   E+K +  E + Q   
Sbjct: 842  KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAE-QLQAET 900

Query: 1061 ELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESK 1120
            EL AE    EE ++               K+++ EE   D +S +E  EE N +  +E K
Sbjct: 901  ELFAE---AEEMRA-----------RLAAKKQELEEILHDLESRVEEEEERNQILQNEKK 946

Query: 1121 K 1121
            K
Sbjct: 947  K 947


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  145 bits (367), Expect = 2e-34
 Identities = 268/1297 (20%), Positives = 538/1297 (41%), Gaps = 223/1297 (17%)

Query: 28   EEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSL 87
            E E E+V+    V S +      L+    E+ +L+ Q+ +   E+E  + ++ + E  + 
Sbjct: 1313 EIEAEKVELELKVSSTTSE----LTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAE 1368

Query: 88   ELQGLLEDERL--ASAQQAEVFTKQIQQLQGELRSLREEISLLE---HEKESELKEIEQE 142
             LQ  LE  +L  A  +       ++ +LQ  +    E++S L     EKE+ L +I+ E
Sbjct: 1369 SLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE 1428

Query: 143  LHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAE 202
            +   +  I++L    E  A EH+  I  LQ +LC M+ + E++       E   A  + +
Sbjct: 1429 IIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIG------EESRAKQQIQ 1482

Query: 203  MEMKSSEPSGSLGLSDYSGLQEEL-------QELRERYHFLNEEYRALQESNSSLTGQLA 255
             +++++  S    L +   LQEEL       + L +    +  +  A  +   ++ G+LA
Sbjct: 1483 RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLA 1542

Query: 256  DLESERTQRATE---RWLQSQTLSMTSAESQTSEMDFLEPDPEMQL-------------- 298
             L+ ER +  TE     L++Q+LS +S ES    ++ L  D E  +              
Sbjct: 1543 LLQEERDKLITEMDRSLLENQSLS-SSCESLKLALEGLTEDKEKLVKEIESLKSSKIAES 1601

Query: 299  --LRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKC--AQNEVLR 354
               +++ ++ +++   +    + +  E E +QH  +   +E++ L  +L+   A  +   
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661

Query: 355  FQTSHSVTQNEELKSRLCTLQKKYD---TSQDEQNELLKMQLQLQTELRQLKVMKSTLVE 411
             Q   +  + EE+K ++    K         +E+N+ L+ ++    +  + + M++ L  
Sbjct: 1662 KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAK-ECMETLLSS 1720

Query: 412  NQSEKELLCRL----QKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLR------ 461
            N S KE L R+    + L  + Q++  EK+ L E  Q L+ +++ + ++  +L       
Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD 1780

Query: 462  --------------------------------DTVASFKESN---EKDTETH-------A 479
                                            ++V S K +N    KD  +H        
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840

Query: 480  QLQEMKQLYQASKDELERQKHMYDQL--EQDLLLCQLELK--ELKASHPIPEDKGKCANK 535
            Q+ ++K+     ++E ++ K     L  E++ LL Q+  K  ELK              +
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900

Query: 536  CDTLLSRLTELQEKYKASQKEMGQLQMEQC---------------------ELLEDQRR- 573
                LSR+T+L+E  +  + ++ +  M Q                      ELLE + + 
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960

Query: 574  -------MQEEQGQLQEELHRLTLPLPKSGL--LLKSQELLTKLEDLCELQLLYQGMQEE 624
                   ++EE+ QL +E  ++   + K  L  +  +Q+         ELQ L +  Q+E
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020

Query: 625  QKKLIQNQDCVLKEQ----LEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQS-- 678
             K+L   +DC+  ++    LE   +   F ++  Q+ LE   ++ LA++ +  +  Q+  
Sbjct: 2021 VKQL--QKDCIRYQEKISALERTVKALEFVQTESQKDLEITKEN-LAQAVEHRKKAQAEL 2077

Query: 679  ---KLLME--QMQALQVMYDAGQAKQEL---------------------LQQEQGRLLEE 712
               K+L++  Q +A +V+ D  + K+EL                     L+Q + + L+E
Sbjct: 2078 ASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKE 2137

Query: 713  RKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESY 772
            +K +Q  L     E   L+     I+++L    K         +  ++  D+TV    ++
Sbjct: 2138 KKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEV-------QQLQENLDSTVTQLAAF 2190

Query: 773  YKSYTSTQ-------TSSKSFLKSYDSSTSASE---AYGKSYCTT-----SNSSITYKKS 817
             KS +S Q         +K + + +  +  + E      +  C+         SI  ++ 
Sbjct: 2191 TKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL 2250

Query: 818  YGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQL 877
              + S  +  ++ + S    E   + +  +  +    ++L +L+  + +Y  SQ E ++L
Sbjct: 2251 KINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKL 2310

Query: 878  QEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP-QNDKNEIKELQTKL---REL- 932
            + +++ L  +  DL   L+ C+ +       + +  A  QN K   ++L+T L   REL 
Sbjct: 2311 ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELT 2370

Query: 933  -QLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ-------------LREKRPSVVKEA 978
             +L  + +M EQ +++ +    E  +Q    ELRQ              +E+  ++V E 
Sbjct: 2371 SRLHEEINMKEQ-KIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEE 2429

Query: 979  RGKNANKNMNKNANGVK-------MKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLD 1031
              K A    N+    +K        +K        S S L+  +   V  Y +  +R L 
Sbjct: 2430 ENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLS 2489

Query: 1032 GLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKE 1091
             + ++++  +E   E  ++KEE +   G     +  + E AK   +  +  ED  +    
Sbjct: 2490 IILEKDQLIQEAAAENNKLKEEIR---GLRSHMDDLNSENAKLDAELIQYREDLNQVITI 2546

Query: 1092 EDSEEEEDDADSSLESPE-ENNPLRLSESKKSSPTPN 1127
            +DS++++       ++ E EN   +L E  K S   N
Sbjct: 2547 KDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEAN 2583



 Score =  127 bits (319), Expect = 6e-29
 Identities = 267/1269 (21%), Positives = 508/1269 (40%), Gaps = 210/1269 (16%)

Query: 1    MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKG---------------GSVGSLSV 45
            ++ ++G    P      +E +E  +E ++E +Q+QK                 ++  +  
Sbjct: 1991 LEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQT 2050

Query: 46   NKHRGLSLTETEL-------EELRAQVLQLVAELEETRELAGQHEDDSL----ELQGLLE 94
               + L +T+  L       ++ +A++      L++T+  A +   D+L    ELQ   E
Sbjct: 2051 ESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKE 2110

Query: 95   DERLASAQQAEVFTKQIQQLQG----ELRSLREEISLLEHEK---ESELKEIEQELHLAQ 147
              +    Q+ E   ++++Q +     E ++++E++  L  EK   E  + EI+  L+   
Sbjct: 2111 SVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKD 2170

Query: 148  AEIQSLRQAAEDSATE---HESDIASLQEDLCRMQNELEDMER----------------- 187
             E+Q L++  + + T+       ++SLQ+D  R+ +E +  ER                 
Sbjct: 2171 KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKE 2230

Query: 188  ------------------------IRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQ 223
                                     R +++ +I   +A+ E++  +        +   L 
Sbjct: 2231 DNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELL 2290

Query: 224  EELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQ 283
             +L+E R  YH    E   L+    SL  QL DL +   +   ++      +    A+ Q
Sbjct: 2291 SQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ 2350

Query: 284  TSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEEL----------QHHRQV 333
             S+  + + + ++Q  R+      E+++  + K   L    EE           QH +++
Sbjct: 2351 NSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI 2410

Query: 334  SEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQL 393
             E E    Q E    +N VL  +   +V +  +L   L T++K+    + + +  +K   
Sbjct: 2411 KELENLLSQEE---EENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMS 2467

Query: 394  QLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCH 453
             LQ +                   ++   Q+L  +H ++  EK++L++       +L   
Sbjct: 2468 SLQND----------------RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKL--- 2508

Query: 454  EAELQHLRDTVASFKESNEK-DTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLC 512
            + E++ LR  +      N K D E     +++ Q+    KD  ++Q  +  QL+Q+    
Sbjct: 2509 KEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI-TIKDSQQKQL-LEVQLQQN---- 2562

Query: 513  QLELKELKASHPIPEDKGKCANKCDTLLSR-LTELQEKYKASQKEMGQLQMEQCELLEDQ 571
                KEL+  +   E+K K + + +  L R    LQE+ +   KE+  L++   +L    
Sbjct: 2563 ----KELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQV 2618

Query: 572  RRMQEE------QGQL---QEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQ 622
              +QEE        QL   +EE+HRL      S L   SQ+ + +LE+  EL  +    +
Sbjct: 2619 TALQEEGTLGLYHAQLKVKEEEVHRL------SALFSSSQKRIAELEE--ELVCV---QK 2667

Query: 623  EEQKKLIQNQDCVLKEQLEIHEE---LRRFKESHFQEVLENPDD-----SKLAKSSKCNR 674
            E  KK+ + +D + KE   +H +   +R   E+  + V E   D      KL   +K N+
Sbjct: 2668 EAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENK 2727

Query: 675  --NKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQV 732
                Q +     M +LQ   D    + + L+++    L+E  +L+    L  E   LL  
Sbjct: 2728 GLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSE 2787

Query: 733  QSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSK---SFLKS 789
             + S+  + E+   S   +   N+      +  +  +     SY   Q+ SK   S    
Sbjct: 2788 TAFSMNSTEEN---SLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE 2844

Query: 790  YDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDT-CQKSFVSSCTDEEPAEPEDMER 848
             D   +  E + KS      S+     +  STS ++    K  +SS  ++     ++++ 
Sbjct: 2845 RDHLWNELEKFRKSEEGKQRSA-----AQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKN 2899

Query: 849  FEEMVVKV---LIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKEC 905
             ++  +++   + +L  ++A  Q  Q++    Q   E+L  +    + EL     E K  
Sbjct: 2900 LQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRME-KSS 2958

Query: 906  MECLEKPMAPQ-----NDKN-EIKELQTKLRE----------LQLQYQ--------ASMD 941
             E  E+ M  Q     +DK+ ++  LQ  +RE          L++QYQ        AS D
Sbjct: 2959 WEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPD 3018

Query: 942  EQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTK 1001
                L+   E L  QL    +E+ Q         KE R +  N N ++     +   ++ 
Sbjct: 3019 GSQNLVYETELLRTQLNDSLKEIHQ---------KELRIQQLNSNFSQLLE--EKNTLSI 3067

Query: 1002 PCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDE 1061
               DTS+S  E ++    +L + A   K     +      ++     Q K     +   E
Sbjct: 3068 QLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPE 3127

Query: 1062 LVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDD---ADSSLESPEENNPLRLSE 1118
               E  +P+++ S   Q+     +E  E  +  EEE D    A+++L   EE    RL  
Sbjct: 3128 ---ELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEE-QIRRLEH 3183

Query: 1119 SK-KSSPTP 1126
            S+  SS TP
Sbjct: 3184 SEWDSSRTP 3192



 Score =  124 bits (312), Expect = 4e-28
 Identities = 211/1105 (19%), Positives = 480/1105 (43%), Gaps = 120/1105 (10%)

Query: 22   EEEEEVEEEEEQVQKGGSVGSLS-VNKHRGLSLTETELEELRAQVLQLVAELEETRELAG 80
            E++E++ +E E ++      S     KH+ L   + E E L      +  E E  + +  
Sbjct: 1581 EDKEKLVKEIESLKSSKIAESTEWQEKHKEL---QKEYEILLQSYENVSNEAERIQHVVE 1637

Query: 81   QHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIE 140
                +  EL G L     A+ ++ E   KQ+Q+ + E+  ++E++      K+ ++ E+E
Sbjct: 1638 AVRQEKQELYGKLRSTE-ANKKETE---KQLQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693

Query: 141  QELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLR 200
            +E    +AE+      A++      S  AS++E+L R++ E E + +       E  SL 
Sbjct: 1694 EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS 1753

Query: 201  AEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESE 260
             E++    +  G++        ++   E  E++   + +    +E   S+ G+    E +
Sbjct: 1754 EEVQDLKHQIEGNVS-------KQANLEATEKH---DNQTNVTEEGTQSIPGETE--EQD 1801

Query: 261  RTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQEL 320
                +T         S  SA    S+ DF   D E+    QQ+   +E++ G++ + Q+ 
Sbjct: 1802 SLSMSTRPTCSESVPSAKSANPAVSK-DFSSHD-EINNYLQQIDQLKERIAGLEEEKQKN 1859

Query: 321  CCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDT 380
                + L++ +     +      ELK  Q EV +         N++++  L  + K  +T
Sbjct: 1860 KEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMN-----LLNQQIQEELSRVTKLKET 1914

Query: 381  SQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLL 440
            +++E+++L   + +L  +L +L        ++ ++ ++  + + L  + +N+     +L 
Sbjct: 1915 AEEEKDDL---EERLMNQLAELNGSIGNYCQDVTDAQI--KNELLESEMKNLKKCVSELE 1969

Query: 441  ERQQQLQEELQCHEAEL--QHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQ 498
            E +QQL +E    E+E+  ++L     + KE   K   +HA  +E+++L +  + E++  
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK---SHA--KELQELLKEKQQEVK-- 2022

Query: 499  KHMYDQLEQDLLLCQLELKELKASHPIPE-DKGKCANKCDTLLSRLTELQEKYKASQKEM 557
                 QL++D +  Q ++  L+ +    E  + +     +     L +  E  K +Q E+
Sbjct: 2023 -----QLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAEL 2077

Query: 558  GQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLL 617
               ++   +   +  R+  +  +L++EL +      KS +  K ++L  +LE   E  L 
Sbjct: 2078 ASFKVLLDDTQSEAARVLADNLKLKKEL-QSNKESVKSQMKQKDEDLERRLEQAEEKHL- 2135

Query: 618  YQGMQEEQKKLIQNQDCVLKEQLEIHEELRRF------KESHFQEVLENPDD-----SKL 666
                 +E+K + +  D + +E++ + E +         K+   Q++ EN D      +  
Sbjct: 2136 -----KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAF 2190

Query: 667  AKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQE--LLQQEQGRLLEERKRLQADLQLCL 724
             KS    ++ + +++ E  +  +   DA Q+K+E   L+++   +L+++ R    + + +
Sbjct: 2191 TKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLR---QMSIHM 2247

Query: 725  EEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSK 784
            EE+++   +    K   ES  ++   +       +K  DT   +N+        T+    
Sbjct: 2248 EELKINISRLEHDKQIWESKAQTEVQLQ------QKVCDTLQGENKELLSQLEETRHLYH 2301

Query: 785  SFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSC--------T 836
            S         S  ++        SNS    K+  G+       Q++ + +         T
Sbjct: 2302 SSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLET 2361

Query: 837  DEEPAEP------EDMERFEEMVVKVLI-KLQAVQAMYQISQEEHSQLQEQMEKLLAKQK 889
            D + +        E++   E+ ++ +L  K +A+Q      +++H +  +++E LL+++ 
Sbjct: 2362 DLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQE- 2420

Query: 890  DLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMD----EQGR 945
              +EE    E E K+ ++            N++ E    +++  +Q +A +D        
Sbjct: 2421 --EEENIVLEEENKKAVD----------KTNQLMETLKTIKKENIQQKAQLDSFVKSMSS 2468

Query: 946  LLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVK--MKKVTKPC 1003
            L   ++++ G  Q  +E    +  ++  +++EA  +  N  + +   G++  M  +    
Sbjct: 2469 LQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAE--NNKLKEEIRGLRSHMDDLNSEN 2526

Query: 1004 SDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELV 1063
            +      ++ R+ L  V+  K SQ+K   L  + ++ +E+E +  +++E+ KE       
Sbjct: 2527 AKLDAELIQYREDLNQVITIKDSQQK-QLLEVQLQQNKELENKYAKLEEKLKE------- 2578

Query: 1064 AEPADPEEAKSTEDQEENEEDKEEE 1088
            +E A+ +  +S    +E ++D  +E
Sbjct: 2579 SEEANEDLRRSFNALQEEKQDLSKE 2603



 Score =  122 bits (306), Expect = 2e-27
 Identities = 237/1204 (19%), Positives = 493/1204 (40%), Gaps = 177/1204 (14%)

Query: 13   LYEEEEEEEEEEEEVEEE-EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAE 71
            L EE ++++++   ++E+ +EQ ++  ++G               +L +L+ QV + +  
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGD--------------QLRQLQIQVRESI-- 1244

Query: 72   LEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEH- 130
                 +L    + +S      LE+    + +Q          L  +  S  E+ S L+  
Sbjct: 1245 ---DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGG 1301

Query: 131  ----EKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDME 186
                + +++LKEIE E    + E++    +     T+   ++  LQE + +   E+E ++
Sbjct: 1302 TSVAQIKAQLKEIEAE----KVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLK 1357

Query: 187  RIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQES 246
             +  + E+   SL+ ++E    + +G           E L+EL+ +   L +     +E 
Sbjct: 1358 TVSHEAEVHAESLQQKLESSQLQIAG----------LEHLRELQPKLDELQKLISKKEED 1407

Query: 247  NSSLTGQLADLESERTQRATERWLQSQTLSM--TSAESQTSEMDFLEPDPEMQLLRQQLR 304
             S L+GQL++ E+  T+  TE   Q   +    T  E Q  E D  E   ++Q+   +++
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHD--ERIKQLQVELCEMK 1465

Query: 305  DAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRF--------- 355
               E++       Q++  +L+     R+ + +E + LQ EL  A+  + R          
Sbjct: 1466 QKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVES 1525

Query: 356  QTSHSVTQNEELKSRLCTLQKKYDTSQDEQN-------------ELLKMQLQLQTE---- 398
            Q S    + + +  RL  LQ++ D    E +             E LK+ L+  TE    
Sbjct: 1526 QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEK 1585

Query: 399  -LRQLKVMKSTLVENQSE-----KELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQC 452
             +++++ +KS+ +   +E     KEL    + L   ++NV+ E E++    Q + E ++ 
Sbjct: 1586 LVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERI----QHVVEAVRQ 1641

Query: 453  HEAELQ-HLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLL 511
             + EL   LR T A+ KE+ ++  E   +++EMK          E+ +      +Q +L 
Sbjct: 1642 EKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK----------EKMRKFAKSKQQKILE 1691

Query: 512  CQLELKELKAS-HPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED 570
             + E   L+A  HP  +   +C    +TLLS    ++E+ +  + E   L  +   L+ +
Sbjct: 1692 LEEENDRLRAEVHPAGDTAKEC---METLLSSNASMKEELERVKMEYETLSKKFQSLMSE 1748

Query: 571  QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKL-- 628
            +  + EE   +Q+  H++   + K   L  +++   +     E      G  EEQ  L  
Sbjct: 1749 KDSLSEE---VQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM 1805

Query: 629  ------------IQNQDCVLKEQLEIHEELRRF-------------------KESHFQEV 657
                         ++ +  + +    H+E+  +                   K   F + 
Sbjct: 1806 STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQT 1865

Query: 658  LENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQ 717
            LEN  ++ L++ S   ++ + K+L E++  + ++        + +Q+E  R+ + ++  +
Sbjct: 1866 LENEKNTLLSQIS--TKDGELKMLQEEVTKMNLL-------NQQIQEELSRVTKLKETAE 1916

Query: 718  ADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNE-------NCRKTYDTTVDDNE 770
             +    LEE   L  Q   +  S+ +Y +        NE       N +K      ++ +
Sbjct: 1917 EEKD-DLEER--LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973

Query: 771  SYYKSYTSTQTS-SKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSD---- 825
               K  T  ++   K +L+      +  E   KS+       +  K+        D    
Sbjct: 1974 QLVKEKTKVESEIRKEYLEKIQG--AQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRY 2031

Query: 826  ----TCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQM 881
                +  +  V +    +    +D+E  +E + + +   +  QA     +      Q + 
Sbjct: 2032 QEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEA 2091

Query: 882  EKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMD 941
             ++LA    LK+EL + +   K  M+  ++ +  + ++ E K L+ K + +Q +  A   
Sbjct: 2092 ARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK-KNMQEKLDALRR 2150

Query: 942  EQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKE-ARGKNANKNMNKNANGV--KMKK 998
            E+  L     +++  L    +E++QL+E   S V + A    +  ++  + + V  + KK
Sbjct: 2151 EKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKK 2210

Query: 999  VTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEE--------EKKEEMEEEKKQV 1050
              +  SD  +S  E  +  E        Q +   +  EE        E  +++ E K Q 
Sbjct: 2211 WERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQT 2270

Query: 1051 KEEAKEQCGDELVAEP----ADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLE 1106
            + + +++  D L  E     +  EE +      +NE  K E E  +  +++  D  +SLE
Sbjct: 2271 EVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESEL-KSLKDQLTDLSNSLE 2329

Query: 1107 SPEE 1110
              +E
Sbjct: 2330 KCKE 2333



 Score =  117 bits (294), Expect = 5e-26
 Identities = 231/1211 (19%), Positives = 491/1211 (40%), Gaps = 185/1211 (15%)

Query: 56   TELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQA---EVFTKQIQ 112
            T L E R Q+L  V EL    EL  Q +   + L       RL    Q     + T+QI 
Sbjct: 740  TALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIH 799

Query: 113  QLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEH-------E 165
             L  E +S   +I +L++E +    +  ++  L ++ +QS  Q  E    E         
Sbjct: 800  SLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRS-LQSQLQNKESEVLEGAERVRHIS 858

Query: 166  SDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEE 225
            S +  L + L + + E+  M+++  + + ++ +L+  +E K  + +  +  S    + E+
Sbjct: 859  SKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT-EISFS----MTEK 913

Query: 226  LQELRERYHFLNEEYRALQESNSSLTG------QLADLESERTQRATERWLQSQTLSMTS 279
            + +L E    L  E + L+E  + L+       +  + ++E +    + + +       S
Sbjct: 914  MVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQIS 973

Query: 280  AESQTSEMDFLEPDPEMQL------------LRQQLRDAEEQMHGMKNKCQELCCELEEL 327
             E    E D L+ + E +             L Q++   EE++  +K++ ++   E+   
Sbjct: 974  KEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKK---EIPLS 1030

Query: 328  QHHRQVSEEEQRRLQRELKCAQNEV--LRFQTSHSVTQNE-ELKSRLCTLQKKYDTSQDE 384
            +  R   EE++   +   KC  ++   +      ++++ E EL+     L++K    +  
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090

Query: 385  QNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQ--------------------- 423
            Q  + +M   LQ +  Q+ ++++ + ENQ+  + L                         
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150

Query: 424  --------KLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDT 475
                    K  L+ + +  EKEK  + Q++LQE L   +A L+  ++     +E  ++  
Sbjct: 1151 CTGSSEHWKPELEEKILALEKEKE-QLQKKLQEALTSRKAILKKAQEKERHLREELKQQK 1209

Query: 476  ETHAQLQE---------------MKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELK 520
            + + +LQE               ++QL    ++ ++ +    DQ E       LE    K
Sbjct: 1210 DDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFK 1269

Query: 521  ASHPIPEDKGKCANKCDTLLSR------------LTELQEKYKASQKEMGQLQMEQCELL 568
            A+          +N C    S             + +++ + K  + E  +L+++     
Sbjct: 1270 ATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTT 1329

Query: 569  EDQRRMQEEQGQLQEELHRLTLPLPKSGLL-----LKSQELLTKLEDLCELQLL-YQGMQ 622
             +  +  EE  QLQE++++  L +     +     + ++ L  KLE   +LQ+   + ++
Sbjct: 1330 SELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLES-SQLQIAGLEHLR 1388

Query: 623  EEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQ------EVLENPDDSKLAKSSKCNRNK 676
            E Q KL + Q  + K++ ++     +  E          E++E  D   L K+       
Sbjct: 1389 ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQED---LIKALHTQLEM 1445

Query: 677  QSKLLMEQMQALQV-----------MYDAGQAKQELLQQEQGRL------LEERKRLQAD 719
            Q+K   E+++ LQV           + +  +AKQ++ ++ Q  L      L+E K LQ +
Sbjct: 1446 QAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEE 1505

Query: 720  LQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTST 779
            L L    ++ L      ++  + +  K   +++      ++  D  + + +       S 
Sbjct: 1506 LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL 1565

Query: 780  QTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEE 839
             +S +S   + +  T   E   K   +  +S I     +         +   +    +  
Sbjct: 1566 SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENV 1625

Query: 840  PAEPEDMERFEEMV----VKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQK------ 889
              E E ++   E V     ++  KL++ +A  + ++++  + +++ME++  K +      
Sbjct: 1626 SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSK 1685

Query: 890  -----DLKEELDACEREF-------KECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQ 937
                 +L+EE D    E        KECME L    A    K E++ ++ +   L  ++Q
Sbjct: 1686 QQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASM--KEELERVKMEYETLSKKFQ 1743

Query: 938  ASMDEQGRLLV----VQEQLEGQL-QCCQEELRQLREKRPSVVKEARGKNANKNMNKNAN 992
            + M E+  L      ++ Q+EG + +    E  +  + + +V +E  G  +     +  +
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEE--GTQSIPGETEEQD 1801

Query: 993  GVKMKKVTKP-CSDTSESDLETRKSL--------EVVLYYKASQR---KLDGLAKEEEKK 1040
             + M   T+P CS++  S      ++        E+  Y +   +   ++ GL +E++K 
Sbjct: 1802 SLSMS--TRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKN 1859

Query: 1041 EE----MEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTE--DQEENEEDKEEEEKEEDS 1094
            +E    +E EK  +  +   + G+  + +    EE       +Q+  EE     + +E +
Sbjct: 1860 KEFSQTLENEKNTLLSQISTKDGELKMLQ----EEVTKMNLLNQQIQEELSRVTKLKETA 1915

Query: 1095 EEEEDDADSSL 1105
            EEE+DD +  L
Sbjct: 1916 EEEKDDLEERL 1926



 Score =  109 bits (273), Expect = 1e-23
 Identities = 265/1305 (20%), Positives = 517/1305 (39%), Gaps = 231/1305 (17%)

Query: 5    EGEVLLPALYEEEEEEEEEEEEVEEEEEQVQK------------GGSVGSLSVNKHRGLS 52
            +G  +LP   + EE+  + ++   EEE +++K                  L+  +    +
Sbjct: 117  QGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPA 176

Query: 53   LTETELEE--LRAQVLQ--------LVAELEETR-ELAGQ----HEDDSLELQ-GLLEDE 96
             + TE+EE  +  Q LQ        L A+L +T+ E A Q     +D   E Q  L EDE
Sbjct: 177  QSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDE 236

Query: 97   RLASAQQAEVFTKQIQQLQGELRSLREE----------ISLLEHE---KESELKEIEQEL 143
             L    QA+V T+  Q+L+   R L E           + LL+ E    E   + + Q+L
Sbjct: 237  LLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQL 296

Query: 144  HLAQAEIQSLRQAAEDSATEH-------ESDIA-------SLQEDLCRMQNELEDMERIR 189
               +AE  +LR   E    E        E ++A       +LQE++  +  + E   + +
Sbjct: 297  QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356

Query: 190  GDYEMEIASL----RAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEE-YRALQ 244
             + E   ++L    +AEME K+S             LQ+  QEL+     L ++  + LQ
Sbjct: 357  AELESRYSALEQKHKAEMEEKTSH---------ILSLQKTGQELQSACDALKDQNSKLLQ 407

Query: 245  ESNSSLTGQ---LADLESERTQRATE--RWLQSQTLSMTSAESQTSEMDFLE------PD 293
            + N         +  LE +  Q++ E  ++L    L      SQTS  D          +
Sbjct: 408  DKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE 467

Query: 294  PEMQLLRQQLRDAEEQMHGM---KNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQN 350
              +  L++++ + E +   +     + +EL  E E+L     + E + R  + + + ++ 
Sbjct: 468  ENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEI 527

Query: 351  EVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLV 410
             ++      S +  E   S    L+  +     E + LL    + Q E+  LK+      
Sbjct: 528  SIVDIANKRSSSAEE---SGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKR 584

Query: 411  ENQSEKELLCRLQKLHLQHQNVTCEKEKLL--------------------ERQQQLQEEL 450
              +++ E+L + +   ++ + +   K K+                       ++Q   E 
Sbjct: 585  AEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEH 644

Query: 451  QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL 510
            Q   +E   L D     K + +   ++ + + ++ Q +Q   DELER K    +LE +  
Sbjct: 645  QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ---DELERLKSQILELELNFH 701

Query: 511  LCQ--------LELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQL-- 560
              Q         + KE+   + + E+  K A+   +  + L+E +++  +  KE+  +  
Sbjct: 702  KAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTE 761

Query: 561  ---QMEQCEL----LEDQRRMQEE-----QGQLQEELHRLTLPLPKSGLLLKSQELLTKL 608
               Q++Q E+     E QRR+  E        L E++H L++        +K + L  +L
Sbjct: 762  LRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD--VKIEVLQNEL 819

Query: 609  EDLCELQLLYQGMQEEQKKLIQN-QDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLA 667
            +D+ +LQ        EQ  LI++ Q  +  ++ E+ E   R +  H    +E  + S+  
Sbjct: 820  DDV-QLQF------SEQSTLIRSLQSQLQNKESEVLEGAERVR--HISSKVE--ELSQAL 868

Query: 668  KSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQE-------LLQQEQGRLLEERKRLQADL 720
               +    K  +LL+E+ + ++ +    + K +        + ++  +L EE+  L  ++
Sbjct: 869  SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI 928

Query: 721  QLCLEEMQLLQVQSPSIKMSLE-------SYGKSYGSMVP----SNENCRKTYDTTVDDN 769
            +   E++ LL     + K  +E          ++Y  M P    S E  +  +D    +N
Sbjct: 929  KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 988

Query: 770  ESYYKSYTSTQTSSKSFLK---SYDSSTSASEAYGKSYCTTSNS------SITYKKSYGS 820
            E   +   +   + K  L+     +   +  +   K     S +           K Y  
Sbjct: 989  EQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSE 1048

Query: 821  TSSSDTCQ--KSFVSSCTDEEPAEPEDM-----------ERFEEMVVKVLIKLQAVQAMY 867
               +  CQ  + ++     E+  E + +           E+F+ +V ++   LQ      
Sbjct: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQI 1108

Query: 868  QISQEEHSQLQEQMEKLLAKQKD------------------------------LKEELDA 897
             + Q E S+ Q  ++KL+    D                              L+E++ A
Sbjct: 1109 DLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILA 1168

Query: 898  CEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQL 957
             E+E ++  + L++ +  +  K  +K+ Q K R L+ + +   D+  RL   QEQ + Q 
Sbjct: 1169 LEKEKEQLQKKLQEALTSR--KAILKKAQEKERHLREELKQQKDDYNRL---QEQFDEQS 1223

Query: 958  QCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSL 1017
            +  +    QLR+ +  V +   GK  + +  ++ +      + +P    +E    T+  L
Sbjct: 1224 KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST--PGLEEPLFKATEQH-HTQPVL 1280

Query: 1018 EVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTED 1077
            E  L         D  A   +    + + K Q+KE   E+   EL       E  K +E+
Sbjct: 1281 ESNLCPDWPSHSED--ASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEE 1338

Query: 1078 -----QEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLS 1117
                 ++ N++  E E  +  S E E  A+ SL+   E++ L+++
Sbjct: 1339 VFQLQEQINKQGLEIESLKTVSHEAEVHAE-SLQQKLESSQLQIA 1382



 Score =  103 bits (258), Expect = 7e-22
 Identities = 223/1199 (18%), Positives = 494/1199 (41%), Gaps = 148/1199 (12%)

Query: 15   EEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEE 74
            +++ + ++++E ++EE +       +  L ++    L+     +EE++AQ   ++    +
Sbjct: 70   QKDVQLQQKDEALQEERKAADN--KIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ 127

Query: 75   TRELAGQHEDDSLELQ--------GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEIS 126
            + E   +H+  S E +         L E E L S  QA++   Q +Q       + E + 
Sbjct: 128  SEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVM 187

Query: 127  LLE--HEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELED 184
            + +   EKE  +  ++ +L   QAE Q+ +Q   +     E+ +   +++L ++  + + 
Sbjct: 188  MKQQLQEKEEFISTLQAQLSQTQAE-QAAQQVVREKDARFETQVRLHEDELLQLVTQAD- 245

Query: 185  MERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQ 244
               +  + + ++  L+ ++E       G   + D   LQ+EL    +R   L+++ + ++
Sbjct: 246  ---VETEMQQKLRVLQRKLEEHEESLVGRAQVVDL--LQQELTAAEQRNQILSQQLQQME 300

Query: 245  ESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLR 304
              +++L          R    TER      L     E    ++ F     EM  L +Q  
Sbjct: 301  AEHNTL----------RNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE 350

Query: 305  DAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQ-----RELKCAQNEVLRFQTSH 359
             A +    ++++   L     E +H  ++ E+    L      +EL+ A + +    +  
Sbjct: 351  QAGQAQAELESRYSAL-----EQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL 405

Query: 360  SVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKS-TLVENQS---- 414
               +NE+      T+Q+  D  Q +  E+ +   +L  +  +     S   V N+     
Sbjct: 406  LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV 465

Query: 415  EKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKD 474
             +E +  LQK  ++ +N   EK  LL    +L EEL+    +L      + +   + E D
Sbjct: 466  TEENIASLQKRVVELEN---EKGALLLSSIEL-EELKAENEKLSSQITLLEAQNRTGEAD 521

Query: 475  TE-THAQLQEMKQLYQASKDELERQ--KHMYDQLEQDLLLCQLELKELKASHPI--PEDK 529
             E +   + ++     +S +E  +   ++ + Q  ++L +  LE+KE +        + +
Sbjct: 522  REVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ 581

Query: 530  GKCANKCDTLLSRLTELQE---------KYKASQKEMGQ----LQMEQCEL--LEDQRRM 574
            GK A + D  +    E+++         K K   ++ GQ    +  E+  L  +E ++  
Sbjct: 582  GKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAS 641

Query: 575  QEEQGQLQEELHRLTLPLPKSGLLLKS-------------------QELLTKLE-DLCEL 614
             E Q +  EE     + L  +G+ LKS                   Q+ L +L+  + EL
Sbjct: 642  TEHQSRTSEE-----ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILEL 696

Query: 615  QLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKE------SHFQEVLENPD------ 662
            +L +   QE  +K   N D   KE   +++ +  FK+      S F  + E  D      
Sbjct: 697  ELNFHKAQEIYEK---NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV 753

Query: 663  -DSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQ 721
             +  +    +    +    L E  +  ++ Y++  A   LL ++   L  E K     ++
Sbjct: 754  KELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIE 813

Query: 722  LC---LEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDD--NESYYKSY 776
            +    L+++QL   +  ++  SL+S  ++  S V       +   + V++       K  
Sbjct: 814  VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873

Query: 777  TSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNS-SITYKK--------SYGSTSSSDTC 827
              T+       K  D  T       K    T  S S+T K         S G    +   
Sbjct: 874  EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933

Query: 828  QKSFVSSCTDEEPAEPED--------MERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQE 879
            Q + +S   + +  + E+         + ++EM     I  + +Q  + + ++E+ Q + 
Sbjct: 934  QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR 993

Query: 880  QMEKLLAKQKDLKEELDACEREFKECMECLEKPM-APQNDKNEIKE-----------LQT 927
            +++  L  +K+L + +   E E     +  +K +   + ++ E++E           + +
Sbjct: 994  KLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTS 1053

Query: 928  KLRELQLQYQASMDE-QGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
            K +E+++  + ++ E +  L  +++ LE +L   +E+ + L ++    +++   +     
Sbjct: 1054 KCQEIEIYLKQTISEKEVELQHIRKDLEEKL-AAEEQFQALVKQMNQTLQDKTNQIDLLQ 1112

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEE 1046
               + N   ++K+    +D S+ D        VV+    +        + EEK   +E+E
Sbjct: 1113 AEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKE 1172

Query: 1047 KKQVKEEAKEQ-CGDELVAEPADPEEAKSTED--QEENEEDKEEEEKEEDSEEEEDDAD 1102
            K+Q++++ +E     + + + A  +E    E+  Q++++ ++ +E+ +E S+E E+  D
Sbjct: 1173 KEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGD 1231



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 80/376 (21%), Positives = 165/376 (43%), Gaps = 34/376 (9%)

Query: 788  KSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPE-DM 846
            K+ D+     + + K+  T+ N  I   K+ G T      Q     S  D+   E E ++
Sbjct: 87   KAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEI 146

Query: 847  ERFEEMVVKVLIKLQAVQA-MYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKEC 905
            E+ +  + +    +  +QA + Q   E+ +Q   +ME+ +  ++ L+E+ +       + 
Sbjct: 147  EKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQL 206

Query: 906  MECLEKPMAPQ--NDKNEIKELQTKLRE---LQLQYQASMDE--QGRLLVVQEQLE---- 954
             +   +  A Q   +K+   E Q +L E   LQL  QA ++   Q +L V+Q +LE    
Sbjct: 207  SQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEE 266

Query: 955  ---GQLQCC---QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSE 1008
               G+ Q     Q+EL    ++   + ++ +   A  N  +N    + ++ +K   +  E
Sbjct: 267  SLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREE-SKILLEKME 325

Query: 1009 SDLETRK----SLEVVLYYKASQRKLDGLAKEE--------EKKEEMEEEKKQVKEEAKE 1056
             ++  RK    +L+  +++   Q +  G A+ E        E+K + E E+K     + +
Sbjct: 326  LEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQ 385

Query: 1057 QCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRL 1116
            + G EL +     ++  S   Q++NE+  +  +  +  E++      S E  +  N L L
Sbjct: 386  KTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQ--QKSKEISQFLNRLPL 443

Query: 1117 SESKKSSPTPNPPIFS 1132
             + + +S T  P +++
Sbjct: 444  QQHETASQTSFPDVYN 459



 Score = 32.3 bits (72), Expect = 2.7
 Identities = 48/192 (25%), Positives = 78/192 (40%), Gaps = 28/192 (14%)

Query: 909  LEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQ-----EQLEGQLQCCQEE 963
            +  P+ P+  +    E     +E  +Q + +  EQ   LVV+      Q + QLQ   E 
Sbjct: 26   MRAPLDPELHQESDMEFNNTTQE-DVQERLAYAEQ---LVVELKDIIRQKDVQLQQKDEA 81

Query: 964  LRQLREKRPSVVKEAR--GKNANKNMNKNANGVKMKKVTK-PCSDTSESDLETRKSLEVV 1020
            L++ R+   + +K+ +   K    ++NK    +K +  T  P    SE  L         
Sbjct: 82   LQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLS-------- 133

Query: 1021 LYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEE 1080
                    K D  + EEE + E  + K Q KEE       +L    A+     STE +E 
Sbjct: 134  --------KHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEF 185

Query: 1081 NEEDKEEEEKEE 1092
                ++ +EKEE
Sbjct: 186  VMMKQQLQEKEE 197



 Score = 31.6 bits (70), Expect = 4.6
 Identities = 30/119 (25%), Positives = 54/119 (45%), Gaps = 26/119 (21%)

Query: 1004 SDTSESDLETRKSL--EVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVK---------- 1051
            ++T++ D++ R +   ++V+  K   R+ D   + ++K E ++EE+K             
Sbjct: 43   NNTTQEDVQERLAYAEQLVVELKDIIRQKD--VQLQQKDEALQEERKAADNKIKKLKLHA 100

Query: 1052 -----------EEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEED 1099
                       EE K Q G  L  EP   EE  S  D+   EE+ E E+ +   +E+E+
Sbjct: 101  KAKLTSLNKYIEEMKAQGGTVLPTEP-QSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEE 158


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  145 bits (366), Expect = 2e-34
 Identities = 231/1139 (20%), Positives = 477/1139 (41%), Gaps = 100/1139 (8%)

Query: 13   LYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAEL 72
            L  E +EEE++++ +  E++  +K          + R       + EE R Q L+   E 
Sbjct: 286  LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345

Query: 73   EETRELAGQHEDDSLE--LQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEH 130
               ++L  + E++  E  L+   E+ER     + E   ++ QQL+ E + LR E  L   
Sbjct: 346  RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE-QQLRREQQLRRE 404

Query: 131  EKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRG 190
            ++    +++ +E  L +   Q LR+  E+   E + +    ++ L R Q E  D   ++ 
Sbjct: 405  QQLRREQQLRREQQLRRE--QQLRREQEEERHEQKHEQERREQRLKREQEERRDW--LKR 460

Query: 191  DYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSL 250
            + E E    R E E +  +             +++ +E RER+  L EE R  Q+     
Sbjct: 461  EEETE----RHEQERRKQQLK-----------RDQEEERRERWLKLEEEERREQQERREQ 505

Query: 251  TGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQM 310
              QL   + ER ++  +R  + + L       Q           E +  R+QL   EE+ 
Sbjct: 506  --QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR-------EQEERREQLLKREEEK 556

Query: 311  HGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSR 370
              ++ + +E   + E+ +   Q+ + E+ R Q+ LK  Q E L  +      +  E + R
Sbjct: 557  R-LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615

Query: 371  LCTLQKKYDTSQDEQNELLKMQLQLQTELRQLK----VMKSTLVENQSEKELLCRLQKLH 426
                 K+ +  ++ + +LLK + Q +   +QL+      +   ++ + E+E L   Q+L 
Sbjct: 616  REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL--EQRLK 673

Query: 427  LQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQ 486
             +H+    E+E   E Q+Q +E ++    + Q   ++ A  ++S      +  + QE ++
Sbjct: 674  REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK---VYSRPRKQEGQR 730

Query: 487  LYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTEL 546
              Q  +++  R++      E++    Q + +E +          + + +    LS    L
Sbjct: 731  RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790

Query: 547  QEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLT 606
            +E+ +   +   + Q EQ  L E++ + Q  + + + E         K    L+ +E L 
Sbjct: 791  REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE---------KELQFLEEEEQLQ 841

Query: 607  KLEDLCELQLLYQGMQEEQKK---LIQNQDCVLKEQLEIHEELRR---FKESHFQEVLEN 660
            + E   +LQ    G+QE+Q++     Q +D   + QLE   + RR   + +   QE L  
Sbjct: 842  RRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK 901

Query: 661  PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELL---QQEQGRLLEERKRLQ 717
                   +  +  R ++ K   ++ +      +  Q ++E L   ++E+ R  E  ++ +
Sbjct: 902  EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961

Query: 718  ADLQLCLEEMQLLQVQSPSIKMSLE---SYGKSYGSMVPSNENCRKTYD-TTVDDNESYY 773
             D +L  +E QLL  + P  +   E    Y +         +  R+  +     + E  Y
Sbjct: 962  KDKKLQQKEEQLLG-EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020

Query: 774  KSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVS 833
            +     Q   +  L+         E   + Y          ++  G    +   Q+    
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRLQER-ERQYREEEELQQEEEQLLGEERETRRRQE---- 1075

Query: 834  SCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKE 893
               + +  + E++++ EE +++   + +  Q   +  +EE  +LQ++ E+LL ++++ K 
Sbjct: 1076 --LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE-EELQQEEEQLLREERE-KR 1131

Query: 894  ELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQL 953
                 ER+++E  E        Q ++  ++E   K R  +L+ Q   +E+     +Q++ 
Sbjct: 1132 RRQELERQYREEEE------VQQEEEQLLREEPEKRRRQELERQYREEEE-----LQQEE 1180

Query: 954  EGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLET 1013
            E  L+  QE+ RQ RE++    +E + +   +          +K   +P  + +  D + 
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240

Query: 1014 ----------RKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELV 1063
                      R+  +  L  + SQ+ L  L  E+++++  +E ++   ++      +E  
Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW--QQRDRHFPEEEQ 1298

Query: 1064 AEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDD----ADSSLESPEENNPLRLSE 1118
             E  + +EAK  + + + E+    EE+EE    +E D     +  L    E  PLR  E
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357



 Score =  144 bits (362), Expect = 6e-34
 Identities = 254/1174 (21%), Positives = 495/1174 (42%), Gaps = 163/1174 (13%)

Query: 15   EEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEE 74
            E  E++EE  E+ E  E+Q ++          + R   L   + EE R Q L+   E EE
Sbjct: 313  ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE-EE 371

Query: 75   TRELAGQHEDDSLELQGLLEDERLASAQQA--------EVFTKQIQQLQGELRSLREEIS 126
             RE   + E      Q L  +++L   QQ         E   ++ QQL+ E + LR E  
Sbjct: 372  RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRREQE 430

Query: 127  LLEHEKESELKEIEQELHLAQAEIQS-LRQAAEDSATEHESDIASLQEDLCRMQNE---- 181
               HE++ E +  EQ L   Q E +  L++  E    E E     L+ D    + E    
Sbjct: 431  EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490

Query: 182  LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYR 241
            LE+ ER R   E     LR E E +  +             QEE + L++R     +  R
Sbjct: 491  LEEEER-REQQERREQQLRREQEERREQRLKR---------QEEEERLQQRLRSEQQLRR 540

Query: 242  ALQESNSSLTGQLAD--LESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
              +E    L  +  +  LE ER ++  +R  + +   +   E +  +   L+ + E +L 
Sbjct: 541  EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR-LKREQEERLE 599

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQV--SEEEQRRLQRELKCAQNEVLRFQT 357
            ++  R+  E++   + + Q L  E  E +  +Q+  SEE++ R Q++L+  Q E  R Q 
Sbjct: 600  QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE-RREQR 658

Query: 358  SHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE 417
                 + E L+ RL    K+    +  + EL + + +   E  + ++ K    + Q E E
Sbjct: 659  LKREEEEERLEQRL----KREHEEERREQELAEEEQEQARERIKSRIPKW---QWQLESE 711

Query: 418  LLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTET 477
               R  K++ + +     K++   R+Q+ +E+ +  E+ELQ   +  A  ++  E+    
Sbjct: 712  ADARQSKVYSRPR-----KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766

Query: 478  HAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCD 537
                 + ++  +  +  L  +  + +Q E+ L   + + +E +   P  E+K +   +  
Sbjct: 767  FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL-PEEEEKEQRRRQRR 825

Query: 538  TLLSRLTELQEKYKASQKEMGQ-LQMEQCELLEDQ--------RRMQEEQGQLQEELHRL 588
                 L  L+E+ +  ++E  Q LQ E+  L EDQ        RR Q+ + QL+EE  R 
Sbjct: 826  EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885

Query: 589  TLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRR 648
               L     L   QE L K + L         +QEE+++L + +    +E+    E+ R+
Sbjct: 886  RHTLYAKPAL---QEQLRKEQQL---------LQEEEEELQREE----REKRRRQEQERQ 929

Query: 649  FKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELL--QQEQ 706
            ++E   +E L+  ++  L +  +  R ++ +    + + LQ      Q +++LL  + E+
Sbjct: 930  YRE---EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ------QKEEQLLGEEPEK 980

Query: 707  GRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTV 766
             R  E  K+ + + +L  EE QLL+ +                      E  R+      
Sbjct: 981  RRRQEREKKYREEEELQQEEEQLLREE---------------------REKRRR------ 1013

Query: 767  DDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDT 826
             + E  Y+     Q   +  L+         E   + Y          ++  G    +  
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERE-RQYREEEELQQEEEQLLGEERETRR 1072

Query: 827  CQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLA 886
             Q+       + +  + E++++ EE +++   + +  Q   +  +EE  +LQ++ E+LL 
Sbjct: 1073 RQE------LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE-ELQQEEEQLLR 1125

Query: 887  KQKDLK--EELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQG 944
            ++++ +  +EL+   RE +E  +  E+ +  + +K   +EL+ + RE     +  + ++ 
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE-----EEELQQEE 1180

Query: 945  RLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNA---------NGVK 995
              L+ +EQ + +    QE  RQ RE+     ++ + +  +++   +          N V+
Sbjct: 1181 EQLLREEQEKRR----QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236

Query: 996  MKKV------TKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKE-----------EE 1038
              KV       +      +S L  R+S + + +    Q++ D   +            EE
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE 1296

Query: 1039 KKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEED----- 1093
            ++ E EE+K+  + + K Q   +L+ E  + +  +   D++  EE++  +E+EE      
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356

Query: 1094 ------SEEEEDDADSSLESPEENNPLRLSESKK 1121
                   EEE    +   +  EE   LR  E ++
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERER 1390



 Score =  142 bits (357), Expect = 2e-33
 Identities = 220/1131 (19%), Positives = 481/1131 (42%), Gaps = 122/1131 (10%)

Query: 14   YEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELE 73
            +E EE  +EE+    E  E  +KG         + +     E E +E R +   L  E E
Sbjct: 199  HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258

Query: 74   ETRELAGQH----EDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLE 129
            + +E   Q     +++  +L+ L   E     Q+ E   +++++ Q   R   EE    +
Sbjct: 259  KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318

Query: 130  HEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIR 189
             E+  + +  EQ+    + +++  ++   +     E +    ++ L R Q E    +++R
Sbjct: 319  EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378

Query: 190  GDYEM-EIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNS 248
             + ++     LR E +++  +      L     L+ E Q  RE+     ++ R  QE   
Sbjct: 379  REQQLRREQQLRREQQLRREQQ-----LRREQQLRREQQLRREQQLRREQQLRREQEEER 433

Query: 249  SLTGQLADLESERTQRATER---WLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLR- 304
                   +   +R +R  E    WL+ +    T    Q      L+ D E +   + L+ 
Sbjct: 434  HEQKHEQERREQRLKREQEERRDWLKRE--EETERHEQERRKQQLKRDQEEERRERWLKL 491

Query: 305  DAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQN 364
            + EE+    + + Q+L  E EE +  R   +EE+ RLQ+ L+  Q   LR        + 
Sbjct: 492  EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ--LR-------REQ 542

Query: 365  EELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQK 424
            EE + +L   +++    Q+ + + LK     + E R+ +++K    E +  ++ L R Q+
Sbjct: 543  EERREQLLKREEEKRLEQERREQRLKR----EQEERRDQLLKR---EEERRQQRLKREQE 595

Query: 425  LHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEM 484
              L+ Q +  E+ + LE++++ ++ L+  E E +  +  + S ++   +  +   + QE 
Sbjct: 596  ERLE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654

Query: 485  KQLYQASKDELER------QKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDT 538
            ++     ++E ER      ++H  ++ EQ+L   + E    +    IP+ + +  ++ D 
Sbjct: 655  REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714

Query: 539  LLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEE-QGQLQEELHRLTLPLPKSGL 597
              S++      Y   +K+ GQ + ++ E  E +RR + E Q Q +E  HR      +   
Sbjct: 715  RQSKV------YSRPRKQEGQRRRQEQE--EKRRRRESELQWQEEERAHRQQQEEEQRRD 766

Query: 598  LLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEV 657
                 +   K E   +       ++E++++ ++ ++   +EQ  + EE    KE   ++ 
Sbjct: 767  FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE--EEKEQRRRQR 824

Query: 658  LENPDDSK-LAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQE-QGRLLEERKR 715
             E   + + L +  +  R ++++ L E+   LQ   +  +++++   Q+ + +L EERKR
Sbjct: 825  REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884

Query: 716  LQADL-------QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDD 768
             +  L       +   +E QLLQ +   ++                 E  R+       +
Sbjct: 885  RRHTLYAKPALQEQLRKEQQLLQEEEEELQRE-------------EREKRRR------QE 925

Query: 769  NESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQ 828
             E  Y+     Q   +  L+         E   + Y          ++  G        Q
Sbjct: 926  QERQYREEEQLQQEEEQLLREEREKRRRQER-ERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984

Query: 829  KSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQ 888
            +       +++  E E++++ EE +++   + +  Q  ++    +  +LQ++ E+LL ++
Sbjct: 985  E------REKKYREEEELQQEEEQLLREEREKRRRQE-WERQYRKKDELQQEEEQLLREE 1037

Query: 889  KDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLV 948
            ++ K  L   ER+++E  E  ++      ++ E +  Q   R+ + + +   +E+  L  
Sbjct: 1038 RE-KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096

Query: 949  VQE---QLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSD 1005
              E   + E + QC +EE  +L+++   +++E R K   + + +                
Sbjct: 1097 EPEKRRRQERERQCREEE--ELQQEEEQLLREEREKRRRQELER---------------- 1138

Query: 1006 TSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAE 1065
                  + R+  EV       Q++ + L +EE +K   +E ++Q +EE + Q  +E +  
Sbjct: 1139 ------QYREEEEV-------QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185

Query: 1066 PADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLE-SPEENNPLR 1115
                +  +  E Q   EE+ + +++++   +E+  +D   +  PE+ N +R
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236



 Score =  139 bits (350), Expect = 2e-32
 Identities = 237/1058 (22%), Positives = 445/1058 (42%), Gaps = 119/1058 (11%)

Query: 93   LEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHE-KESELKEIEQELHLAQAEIQ 151
            L++E+ A     E   +  +Q + + R    +  L E   +    K  EQE  LA+ E Q
Sbjct: 95   LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154

Query: 152  SLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYE-MEIASLRAEMEMKSSEP 210
            S +Q   +       D     E+L R + E ++ E  R + E ++        E    E 
Sbjct: 155  SEKQERLEQRDRQRRD-----EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209

Query: 211  SGSLGLSDY--SGLQEELQELRERYH--FLNEEYRALQESNSSLTGQLADLESERTQRAT 266
                 L +    G +E+ Q+ RER    F  EE +  ++  + L  +   L+ E  QR  
Sbjct: 210  LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR-- 267

Query: 267  ERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLR--QQLRDAEEQMHGMKNKCQELCCEL 324
            +R LQ +   +   E Q    +  E + + Q LR  QQLR  +E+         E   + 
Sbjct: 268  QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE---------ERREQQ 318

Query: 325  EELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDE 384
            EE +  ++  E+++ R +++L+  Q E    +    + + +E + R   L+++ +  + E
Sbjct: 319  EERREQQERREQQEERREQQLRREQEE----RREQQLRREQEEERREQQLRREQEEERRE 374

Query: 385  QNELLKMQLQLQTELRQLKVMKSTLVENQSEKEL-LCRLQKLHLQHQNVTCEKEKLLERQ 443
            Q    + QL+ + +LR+ + ++    E Q  +E  L R Q+L  + Q     +E+ L R+
Sbjct: 375  QQLRREQQLRREQQLRREQQLRR---EQQLRREQQLRREQQLRREQQ---LRREQQLRRE 428

Query: 444  QQLQEELQCHEAEL--QHLRDTVASFKE--SNEKDTETHAQLQEMKQLYQASKDELERQK 499
            Q+ +   Q HE E   Q L+      ++    E++TE H Q +  +QL    +D+ E ++
Sbjct: 429  QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL---KRDQEEERR 485

Query: 500  HMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQ 559
              + +LE++    Q E +E +      E +       +  L R  E +E+ +   +   Q
Sbjct: 486  ERWLKLEEEERREQQERREQQLRREQEERR-------EQRLKRQEE-EERLQQRLRSEQQ 537

Query: 560  LQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQ 619
            L+ EQ E  E   + +EE+   QE                + Q L  + E+  + QLL +
Sbjct: 538  LRREQEERREQLLKREEEKRLEQER---------------REQRLKREQEERRD-QLLKR 581

Query: 620  GMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVL--ENPDDSK---LAKSSKCNR 674
              +  Q++L + Q+  L+++L+  E  R  +E   ++ L  E P++ +   L KS +   
Sbjct: 582  EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641

Query: 675  NKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEM----QLL 730
             +Q +L  EQ +  +      + ++E L+Q   R  EE +R Q   +L  EE     + +
Sbjct: 642  RRQQQLRREQQERREQRLKR-EEEEERLEQRLKREHEEERREQ---ELAEEEQEQARERI 697

Query: 731  QVQSPSIKMSLESYGKSYGSMVPS-------------NENCRKTYDTTVDDNESYYKSYT 777
            + + P  +  LES   +  S V S              E  R+  ++ +   E   +++ 
Sbjct: 698  KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE-ERAHR 756

Query: 778  STQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTD 837
              Q   +    ++          G+   +        ++           ++ F+    +
Sbjct: 757  QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE 816

Query: 838  EEPAEPEDMERFEEM-VVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQ--KDLKEE 894
            +E    +  ER +E+  ++   +LQ  +   Q+ QEE   LQE  E+  +++  +D K  
Sbjct: 817  KEQRRRQRREREKELQFLEEEEQLQRRERAQQL-QEEEDGLQEDQERRRSQEQRRDQKWR 875

Query: 895  LDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQAS--MDEQGRLLVVQEQ 952
                E   +       KP   +  + E + LQ +  ELQ + +      EQ R    +EQ
Sbjct: 876  WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ 935

Query: 953  LEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLE 1012
            L+      QEE + LRE+R    ++ R +   K+          KK+ +        + E
Sbjct: 936  LQ------QEEEQLLREEREKRRRQERERQYRKD----------KKLQQKEEQLLGEEPE 979

Query: 1013 TRKSLEVVLYYK----ASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPAD 1068
             R+  E    Y+      Q +   L +E EK+   E E++  K++  +Q  ++L+ E  +
Sbjct: 980  KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039

Query: 1069 PEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLE 1106
                +  E Q   EE+ ++EE++   EE E      LE
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077



 Score =  136 bits (343), Expect = 1e-31
 Identities = 231/1133 (20%), Positives = 470/1133 (41%), Gaps = 181/1133 (15%)

Query: 13   LYEEEEEEE---------EEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRA 63
            +++EEEE+E         +EEE+++EEE Q Q+      L   + +   L   EL   R 
Sbjct: 237  VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR-----ELQEEEEQLRKLERQELRRERQ 291

Query: 64   QVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLRE 123
            +  Q    L   ++L  + E++  E Q    +++    QQ E   ++ QQL+ E    RE
Sbjct: 292  EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE---RREQQLRREQEERRE 348

Query: 124  EISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELE 183
            +   L  E+E E +E  Q+L   Q E +  +Q   +     E  +   +E   R + +L 
Sbjct: 349  Q--QLRREQEEERRE--QQLRREQEEERREQQLRREQQLRREQQLR--REQQLRREQQLR 402

Query: 184  DMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRAL 243
              +++R + +     LR E +++  +            L+ E +E  ER+   +E+ R  
Sbjct: 403  REQQLRREQQ-----LRREQQLRREQQ-----------LRREQEE--ERHEQKHEQERRE 444

Query: 244  QESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQL 303
            Q               +R Q     WL+ +    T    Q      L+ D E +   + L
Sbjct: 445  QRL-------------KREQEERRDWLKRE--EETERHEQERRKQQLKRDQEEERRERWL 489

Query: 304  R-DAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVT 362
            + + EE+    + + Q+L  E EE +  R   +EE+ RLQ+ L+  Q   LR        
Sbjct: 490  KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ--LR-------R 540

Query: 363  QNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRL 422
            + EE + +L   +++    Q+ + + LK +     E R+ +++K    E +  ++ L R 
Sbjct: 541  EQEERREQLLKREEEKRLEQERREQRLKRE----QEERRDQLLKR---EEERRQQRLKRE 593

Query: 423  QKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQ 482
            Q+  L+ Q +  E+ + LE++++ ++ L+  E E +  +  + S ++   +  +   + Q
Sbjct: 594  QEERLE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652

Query: 483  EMKQLYQASKDELER------QKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKC 536
            E ++     ++E ER      ++H  ++ EQ+L   + E    +    IP+ + +  ++ 
Sbjct: 653  ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712

Query: 537  DTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEE-QGQLQEELHRLTLPLPKS 595
            D   S++      Y   +K+ GQ + ++ E  E +RR + E Q Q +E  HR        
Sbjct: 713  DARQSKV------YSRPRKQEGQRRRQEQE--EKRRRRESELQWQEEERAHR-------- 756

Query: 596  GLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQ 655
                       + E+       +Q   EE+ +  + +        E  E   R +E   +
Sbjct: 757  ----------QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806

Query: 656  EVLENPDDSKLAKSSKCNRNKQSKL-LMEQMQALQVMYDAGQAKQEL--LQQEQGRLLEE 712
            E    P++ +  +  +  R ++ +L  +E+ + LQ    A Q ++E   LQ++Q R   +
Sbjct: 807  EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ 866

Query: 713  RKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTV---DDN 769
             +R     +  LEE +  +  +   K +L+   +    ++   E   +  +       + 
Sbjct: 867  EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ 926

Query: 770  ESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQK 829
            E  Y+     Q   +  L+         E   + Y          ++  G        Q+
Sbjct: 927  ERQYREEEQLQQEEEQLLREEREKRRRQERE-RQYRKDKKLQQKEEQLLGEEPEKRRRQE 985

Query: 830  SFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQK 889
                   +++  E E++++ EE +++   + +  Q  ++    +  +LQ++ E+LL +++
Sbjct: 986  R------EKKYREEEELQQEEEQLLREEREKRRRQE-WERQYRKKDELQQEEEQLLREER 1038

Query: 890  DLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLR-ELQLQYQASMDEQGRLLV 948
            + K  L   ER+++E     E+ +  + ++   +E +T+ R EL+ QY+           
Sbjct: 1039 E-KRRLQERERQYRE-----EEELQQEEEQLLGEERETRRRQELERQYRK---------- 1082

Query: 949  VQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSE 1008
             +E+L+      QEE + LRE+     ++ R +                     C +  E
Sbjct: 1083 -EEELQ------QEEEQLLREEPEKRRRQERERQ--------------------CREEEE 1115

Query: 1009 SDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPAD 1068
               E  + L                 +E EK+   E E++  +EE  +Q  ++L+ E  +
Sbjct: 1116 LQQEEEQLLR----------------EEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159

Query: 1069 PEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
                +  E Q   EE+ ++EE++   EE+E           E   L+  + K+
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212



 Score =  130 bits (326), Expect = 9e-30
 Identities = 238/1160 (20%), Positives = 468/1160 (40%), Gaps = 126/1160 (10%)

Query: 15   EEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVL-------- 66
            EEE  ++  + E EE  EQ  K   V  L   + R   L   E EE R Q L        
Sbjct: 582  EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641

Query: 67   ----QLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLR 122
                QL  E +E RE   + E++   L+  L+ E     ++ E+  ++ +Q +  ++S  
Sbjct: 642  RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS-- 699

Query: 123  EEISLLEHEKESELKEIEQELHLA--QAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN 180
              I   + + ESE    + +++    + E Q  RQ  E+     ES++   +E+    Q 
Sbjct: 700  -RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758

Query: 181  ELEDMER-IRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQ---EELQELRERYHFL 236
            + E+  R     ++ E  S R    + +  P     L +    Q   EE Q+  +R+   
Sbjct: 759  QEEEQRRDFTWQWQAEEKSERGRQRLSARPP-----LREQRERQLRAEERQQREQRFLPE 813

Query: 237  NEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEM 296
             EE    +        +L  LE E   +  ER  Q Q            E D L+ D E 
Sbjct: 814  EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ-----------EEEDGLQEDQER 862

Query: 297  QLLRQQLRDA------EEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRE---LKC 347
            +  ++Q RD       EE+    ++         E+L+  +Q+ +EE+  LQRE    + 
Sbjct: 863  RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR 922

Query: 348  AQNEVLRFQTSHSVTQNEEL-------KSRLCTLQKKYDTS---QDEQNELLKMQLQLQT 397
             Q +  +++    + Q EE        K R    +++Y      Q ++ +LL  + + + 
Sbjct: 923  RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982

Query: 398  ELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAEL 457
               + K  +    E Q E+E L R ++   + Q    +  K  E QQ+ +E+L   E E 
Sbjct: 983  RQEREKKYREE-EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE-EEQLLREEREK 1040

Query: 458  QHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELK 517
            + L++    ++E  E   E    L E ++  +  + ELERQ    ++L+Q+    +  L+
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRR--RQELERQYRKEEELQQEE---EQLLR 1095

Query: 518  ELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEE 577
            E        E + +C  +       L + +E+    ++E  + Q  + +  E++   QEE
Sbjct: 1096 EEPEKRRRQERERQCREE-----EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150

Query: 578  QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLY-QGMQEEQKKLIQNQDCVL 636
            +  L+EE  +            + QEL  +  +  ELQ    Q ++EEQ+K  Q ++   
Sbjct: 1151 EQLLREEPEKR-----------RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199

Query: 637  KEQLEIHEELR--RFKESHFQEVLE---NPDDSKLAKSSKCNRNKQSKLLMEQMQALQVM 691
            +E+ E+  + R  R+++   +  L+    P+     + +K     +      Q++  Q+ 
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259

Query: 692  -YDAGQAKQELLQQEQGRLLE-ERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYG 749
               + Q  Q LL ++Q R  E ER+R Q   +   EE QL + +    K       +   
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319

Query: 750  SMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSN 809
             +    E  R+  +T    +  + +     Q   +  L+  +      E           
Sbjct: 1320 LLREEREEKRRRQET----DRKFREEEQLLQEREEQPLRRQERDRKFRE----------- 1364

Query: 810  SSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQI 869
              + +++            + F+     EE       ER E   +K   +L+  +   Q+
Sbjct: 1365 EELRHQEQ----------GRKFL-----EEEQRLRRQER-ERKFLKEEQQLRCQEREQQL 1408

Query: 870  SQEEHSQLQEQMEKLLAKQKDLK--EELDACEREFKECMECLEKPMAPQNDKNEIKELQT 927
             Q+   + +E+ ++L  +++D K  EE     R+ +E     E+    Q    + +E + 
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468

Query: 928  KLRELQLQYQASMDEQGRLLVVQEQLEGQ---LQCCQEELRQLREKRPSVVKEA---RGK 981
             L+E + Q     +   + L  ++QL  Q    +  ++ELR    +R  + +E    R +
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528

Query: 982  NANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKE 1041
               K + +     + ++  +   D      E  +  +     + S+++ D   + EE+K 
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588

Query: 1042 EMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDA 1101
              +E++++  E+ ++    E   +     + K  ED++  +E +E++   ++ + +  + 
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648

Query: 1102 DSSLESPEENNPLRLSESKK 1121
            +  L   E    LR    +K
Sbjct: 1649 EPQLRRQEREQQLRHDRDRK 1668



 Score =  130 bits (326), Expect = 9e-30
 Identities = 232/1117 (20%), Positives = 461/1117 (41%), Gaps = 156/1117 (13%)

Query: 11   PALYEEEEEEE----EEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVL 66
            PAL E+  +E+    EEEEE++ EE + ++          ++R     E +L++   Q+L
Sbjct: 893  PALQEQLRKEQQLLQEEEEELQREEREKRRRQE----QERQYR----EEEQLQQEEEQLL 944

Query: 67   QLVAELEETRELAGQHEDDSL----ELQGLLEDERLASAQQAEVFTKQIQQLQGE----L 118
            +   E    +E   Q+  D      E Q L E+      Q+ E   ++ ++LQ E    L
Sbjct: 945  REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004

Query: 119  RSLREEISLLEHE----KESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQED 174
            R  RE+    E E    K+ EL++ E++L   + E + L++   +     E ++   +E 
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQYREEEELQQEEEQ 1062

Query: 175  LCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYH 234
            L   + E    + +   Y  E    + E ++   EP       +    QE  ++ RE   
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEP-------EKRRRQERERQCREEEE 1115

Query: 235  FLNEEYRALQESNSSLTGQLADL---ESERTQRATERWLQSQTLSMTSAESQTSEMDFLE 291
               EE + L+E       Q  +    E E  Q+  E+ L+ +         Q  E  + E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP---EKRRRQELERQYRE 1172

Query: 292  PDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQR-------RLQRE 344
             +   Q   Q LR+ +E+    + +      EL+  +  ++  +E+QR         ++E
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232

Query: 345  LKCAQNEVL-RFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLK 403
                 N+V  + + +    Q E+ + R    Q+       EQ E  + Q + + + R   
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292

Query: 404  VMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDT 463
              +   +E + +KE   R +K   + Q +  E+E+   R+Q+   + +  E  LQ   + 
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK-RRRQETDRKFREEEQLLQEREEQ 1351

Query: 464  VASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQL-EQDLLLCQLELKELKAS 522
                +E + K  E   + QE  + +   +  L RQ+     L E+  L CQ   ++L+  
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR-- 1409

Query: 523  HPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQ 582
                +D+ +   + +  LSR    QE+ +  ++E  Q++ +     E +R+  EE+ QL+
Sbjct: 1410 ----QDRDRKFREEEQQLSR----QERDRKFREEEQQVRRQ-----ERERKFLEEEQQLR 1456

Query: 583  EELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEI 642
            +E HR            + ++LL + E+    Q L++  QE  +K ++ +     +QL  
Sbjct: 1457 QERHRK---------FREEEQLLQEREE----QQLHR--QERDRKFLEEE-----QQLRR 1496

Query: 643  HEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELL 702
             E  R+F+E   +   + P+   L +  + +R ++ +  +++ Q L+      Q + +  
Sbjct: 1497 QERDRKFREQELRS--QEPERKFLEEEQQLHRQQRQRKFLQEEQQLR-----RQERGQQR 1549

Query: 703  QQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTY 762
            +Q++ R   E ++L+ +      E Q L  Q    K  LE         V   E  RK  
Sbjct: 1550 RQDRDRKFREEEQLRQE-----REEQQLSRQERDRKFRLEE------QKVRRQEQERKF- 1597

Query: 763  DTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTS 822
               ++D +   +     Q   +   K  +      E   +                    
Sbjct: 1598 ---MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERD------------ 1642

Query: 823  SSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQME 882
                  + F+     EE  +    ER +++      K +  + + Q  +E+  + QE+  
Sbjct: 1643 ------RKFL-----EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691

Query: 883  KLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDE 942
            K   +++ L+ +    ERE K   E  E+ +  Q  + + +E + +LR+   Q Q    E
Sbjct: 1692 KFREEEQQLRRQ----ERERKFLQE--EQQLRRQELERKFRE-EEQLRQETEQEQLRRQE 1744

Query: 943  QGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKP 1002
            + R ++ +EQL  + +  Q+  RQ R+++    ++ R +   + +    +  K ++  + 
Sbjct: 1745 RYRKILEEEQLRPEREE-QQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQL 1803

Query: 1003 CSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDEL 1062
              +  E  L  ++               DG  + EE++ ++EE+++++++E   Q   E 
Sbjct: 1804 RQEREEQQLRPQQR--------------DGKYRWEEEQLQLEEQEQRLRQERDRQYRAE- 1848

Query: 1063 VAEPADPEEAKSTEDQE--ENEEDKEEEEKEEDSEEE 1097
              E    +E    E+QE  + EE K  +E+E    EE
Sbjct: 1849 --EQFATQEKSRREEQELWQEEEQKRRQERERKLREE 1883



 Score =  124 bits (310), Expect = 7e-28
 Identities = 239/1140 (20%), Positives = 450/1140 (39%), Gaps = 214/1140 (18%)

Query: 1    MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE 60
            ++ +E E       + EE EEE  +++ + EEQ                         EE
Sbjct: 607  VERLEQEERREQRLKREEPEEERRQQLLKSEEQ-------------------------EE 641

Query: 61   LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS 120
             R Q  QL  E +E RE   + E++   L+  L+ E     ++ E+  ++ +Q +  ++S
Sbjct: 642  RRQQ--QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699

Query: 121  LREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN 180
             R      + E E++ ++ +      + E Q  RQ  E+     ES++   +E+    Q 
Sbjct: 700  -RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758

Query: 181  ELEDMER-IRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEE 239
            + E+  R     ++ E  S R    + +  P               L+E RER   L  E
Sbjct: 759  QEEEQRRDFTWQWQAEEKSERGRQRLSARPP---------------LREQRERQ--LRAE 801

Query: 240  YRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
             R  +E       +    E E+ QR  +R              +  E+ FLE + ++Q  
Sbjct: 802  ERQQREQ------RFLPEEEEKEQRRRQR------------REREKELQFLEEEEQLQ-R 842

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSH 359
            R++ +  +E+  G           L+E Q  R+   +EQRR Q+     + E  R +  H
Sbjct: 843  RERAQQLQEEEDG-----------LQEDQERRR--SQEQRRDQKWRWQLEEE--RKRRRH 887

Query: 360  SVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELL 419
            ++     L+ +   L+K+    Q+E+ EL + + + +    Q +  +      Q E++LL
Sbjct: 888  TLYAKPALQEQ---LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944

Query: 420  C-RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETH 478
                +K   Q +     K+K L   QQ +E+L   E E +  ++    ++E  E   E  
Sbjct: 945  REEREKRRRQERERQYRKDKKL---QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001

Query: 479  AQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDT 538
              L+E ++  +  + E ERQ    D+L+Q+                + E++ K       
Sbjct: 1002 QLLREERE--KRRRQEWERQYRKKDELQQE------------EEQLLREEREK------- 1040

Query: 539  LLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLL 598
               RL E + +Y    +E  +LQ E+ +LL ++R  +  Q     EL R      K   L
Sbjct: 1041 --RRLQERERQY----REEEELQQEEEQLLGEERETRRRQ-----ELER---QYRKEEEL 1086

Query: 599  LKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVL 658
             + +E L + E     +   +    E+++L Q ++ +L+E+ E        ++   +E +
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146

Query: 659  ENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQA 718
            +  ++  L +  +  R ++ +    + + LQ      Q +++LL++EQ +  +ER+R   
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQ------QEEEQLLREEQEKRRQERERQYR 1200

Query: 719  DLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTS 778
                  EE +L + +        +          P  EN        V DN+ Y K   +
Sbjct: 1201 ------EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN-------AVRDNKVYCKGREN 1247

Query: 779  TQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDE 838
             Q     F +  DS     +           S    +   G     D  Q+       D 
Sbjct: 1248 EQ-----FRQLEDSQLRDRQ-----------SQQDLQHLLGEQQERDREQERRRWQQRDR 1291

Query: 839  EPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDAC 898
               E E +ER E+   K            + SQEE   L+E+ E     +K  ++E D  
Sbjct: 1292 HFPEEEQLEREEQKEAK---------RRDRKSQEEKQLLREERE-----EKRRRQETDRK 1337

Query: 899  EREFKECM-ECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQ----- 952
             RE ++ + E  E+P+  Q       E   K RE +L++Q    EQGR  + +EQ     
Sbjct: 1338 FREEEQLLQEREEQPLRRQ-------ERDRKFREEELRHQ----EQGRKFLEEEQRLRRQ 1386

Query: 953  -------LEGQLQCCQEELRQLREKRPSVVKE-----ARGKNANKNMNKNANGVKMKKVT 1000
                    E Q   CQE  +QLR+ R    +E     +R +   K   +     + ++  
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER 1446

Query: 1001 KPCSDTSESDLETRKSL--EVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQC 1058
            K   +  +   E  +    E  L  +  +++L      +E+  +  EE++Q++ + +++ 
Sbjct: 1447 KFLEEEQQLRQERHRKFREEEQLLQEREEQQL----HRQERDRKFLEEEQQLRRQERDRK 1502

Query: 1059 GDELVAEPADPEEAKSTEDQEENEEDKEEE--------EKEEDSEEEEDDADSSLESPEE 1110
              E      +PE     E+Q+ + + ++ +         ++E  ++   D D      E+
Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ 1562



 Score =  123 bits (309), Expect = 9e-28
 Identities = 230/1142 (20%), Positives = 463/1142 (40%), Gaps = 144/1142 (12%)

Query: 17   EEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETR 76
            EE ++ E+  + EEEE+ Q+            R     E EL+ L  +      E  + R
Sbjct: 801  EERQQREQRFLPEEEEKEQR-----------RRQRREREKELQFLEEE------EQLQRR 843

Query: 77   ELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEI----SLLEHEK 132
            E A Q +++     GL ED+    +Q+     K   QL+ E +  R  +    +L E  +
Sbjct: 844  ERAQQLQEEE---DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900

Query: 133  ESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDY 192
            + +    E+E  L + E +  R+  ++     E  +   +E L R + E    +     Y
Sbjct: 901  KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960

Query: 193  EMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTG 252
              +    + E ++   EP       +    QE  ++ RE      EE + L+E       
Sbjct: 961  RKDKKLQQKEEQLLGEEP-------EKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013

Query: 253  QLADLE---SERTQRATERWLQSQTLS--MTSAESQTSEMDFLEPDPEMQLLRQQLRDAE 307
            Q  + +    +  Q+  E+ L+ +     +   E Q  E + L+ + E  L  ++     
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073

Query: 308  EQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEEL 367
            +++     K +EL  E E+L        E++RR +RE +C + E L+ Q    + + E  
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEP---EKRRRQERERQCREEEELQ-QEEEQLLREERE 1129

Query: 368  KSRLCTLQKKY---DTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQK 424
            K R   L+++Y   +  Q E+ +LL+ + + +      +  +      Q E++LL   Q+
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQE 1189

Query: 425  LHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEM 484
               Q +     +E+ L+RQ++ Q      E +   L+      KE+  +D + + + +E 
Sbjct: 1190 KRRQERERQYREEEELQRQKRKQRYRD--EDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247

Query: 485  KQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLT 544
            +Q  Q    +L  +     Q +QDL     E +E        E + +   + D       
Sbjct: 1248 EQFRQLEDSQLRDR-----QSQQDLQHLLGEQQERDR-----EQERRRWQQRDRHFPEEE 1297

Query: 545  ELQEKYKASQKEMGQLQMEQCELL----EDQRRMQE------EQGQLQEELHRLTLPLPK 594
            +L+ + +   K   +   E+ +LL    E++RR QE      E+ QL +E     L   +
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357

Query: 595  SGLLLKSQELLTKLED---LCELQLLYQGMQEEQKKLIQNQD---CVLKEQLEIHEELRR 648
                 + +EL  + +    L E Q L +  QE ++K ++ +    C  +EQ    +  R+
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLRR--QERERKFLKEEQQLRCQEREQQLRQDRDRK 1415

Query: 649  FKESHFQEVLENPDDSKLAKSSKCNRN--KQSKLLMEQMQALQVMYDAGQAKQELLQQEQ 706
            F+E   Q++     D K  +  +  R   ++ K L E+ Q  Q  +   + +++LLQ+ +
Sbjct: 1416 FREEE-QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE 1474

Query: 707  GRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTV 766
             + L  ++R +      LEE Q L+ Q    K   +         + S E  RK     +
Sbjct: 1475 EQQLHRQERDRK----FLEEEQQLRRQERDRKFREQE--------LRSQEPERKF----L 1518

Query: 767  DDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDT 826
            ++ +  ++     Q   + FL+                          ++  G     D 
Sbjct: 1519 EEEQQLHR-----QQRQRKFLQEEQQLR--------------------RQERGQQRRQDR 1553

Query: 827  CQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLA 886
             +K F       +  E + + R +E   K  ++ Q V+      QE      EQ  +   
Sbjct: 1554 DRK-FREEEQLRQEREEQQLSR-QERDRKFRLEEQKVRRQ---EQERKFMEDEQQLRRQE 1608

Query: 887  KQKDLKEELDACEREFKECMECLEKPMAPQNDKN-----EIKELQTKLRELQLQYQASMD 941
             Q+ L++E D   RE ++ ++  E+    + +++     E  +L+ + RE QL++     
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRK 1668

Query: 942  EQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKN---ANKNMNKNANGVKMKK 998
             +    ++QE  E QL+  QE  R+ RE+   + ++ R +      + + +     K ++
Sbjct: 1669 FREEEQLLQEGEEQQLRR-QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE 1727

Query: 999  VTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQC 1058
              +   +T +  L  ++    +L             +EE+ + E EE++ + +E  ++  
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKIL-------------EEEQLRPEREEQQLRRQERDRKFR 1774

Query: 1059 GDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSE 1118
             +E + +  + ++ +S E   +  E+++  ++ E+ +      D      EE   L   E
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834

Query: 1119 SK 1120
             +
Sbjct: 1835 QR 1836



 Score =  110 bits (275), Expect = 8e-24
 Identities = 171/744 (22%), Positives = 317/744 (42%), Gaps = 89/744 (11%)

Query: 14   YEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQV-LQLVAEL 72
            Y +E++  + + + E E+E   +   V        +   L +++L + ++Q  LQ +   
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273

Query: 73   EETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEK 132
            ++ R+   +        +   E+E+L   +Q E   ++ ++ Q E + LREE       +
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLEREEQKEA-KRRDRKSQEEKQLLREEREEKRRRQ 1332

Query: 133  ESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE----LEDMERI 188
            E++ K  E+E  L + E Q LR+   D            +E+  R Q +    LE+ +R+
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRRQERDR---------KFREEELRHQEQGRKFLEEEQRL 1383

Query: 189  RGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQEL----RERYHFLNEEYRALQ 244
            R   E E   L+ E +++  E    L        +EE Q+L    R+R     E+    Q
Sbjct: 1384 RRQ-ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442

Query: 245  ESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLR 304
            E       +   L  ER ++  E     Q         Q  +  FLE   E Q LR+Q R
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLE---EEQQLRRQER 1499

Query: 305  DAEEQMHGMKNKCQELCCELEELQHHRQ------VSEE---------EQRRLQRELKCAQ 349
            D + +   ++++  E     EE Q HRQ      + EE         +QRR  R+ K  +
Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE 1559

Query: 350  NEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTL 409
             E LR +        +E + R   L+++    Q+++ + ++ + QL+ +  Q ++ +   
Sbjct: 1560 EEQLRQEREEQQLSRQE-RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618

Query: 410  VENQSEKELLCRL--QKLHLQHQN-VTCEKEKLL---ERQQQL---------QEELQCHE 454
             + + +++LL     Q+LH Q ++    E+E  L   ER+QQL         +EE    E
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678

Query: 455  AELQHLR--DTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLC 512
             E Q LR  +    F+E  ++      + + +++  Q  + ELER+    +QL Q+    
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE-- 1736

Query: 513  QLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQR 572
            Q +L+  +    I E++     + +  L R  E   K++  ++   + + +Q    E  R
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPEREEQQLRR-QERDRKFREEEQLRQEREEQQLRSQESDR 1795

Query: 573  RMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQ 632
            + +EE+   QE   +   P  + G     +E         +LQL     +E++++L Q +
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEE---------QLQL-----EEQEQRLRQER 1841

Query: 633  DCVLK--EQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV 690
            D   +  EQ    E+ RR ++  +QE           +  K  + ++ KL  E ++  Q 
Sbjct: 1842 DRQYRAEEQFATQEKSRREEQELWQE-----------EEQKRRQERERKLREEHIRRQQK 1890

Query: 691  MYDAGQAKQELLQQE---QGRLLE 711
                 +   E+  QE    GRLLE
Sbjct: 1891 EEQRHRQVGEIKSQEGKGHGRLLE 1914



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 147/635 (23%), Positives = 258/635 (40%), Gaps = 100/635 (15%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            ++ E + LL    EE+   +E + +  EEE+ +Q                   E E + L
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ-------------------EREEQPL 1353

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELR-- 119
            R Q        EE R     H++   +   L E++RL   ++   F K+ QQL+ + R  
Sbjct: 1354 RRQERDRKFREEELR-----HQEQGRKF--LEEEQRLRRQERERKFLKEEQQLRCQEREQ 1406

Query: 120  SLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIAS--------- 170
             LR++      E+E +L   E++    + E Q  RQ  E    E E  +           
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466

Query: 171  ---LQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQ 227
               LQE   R + +L   ER R   E E    R E + K  E        +   L+EE Q
Sbjct: 1467 EQLLQE---REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQ 1523

Query: 228  ELRERYH--FLNEEYRALQESNSSLTGQLAD--------LESERTQRATERWLQSQTLSM 277
              R++    FL EE +  ++       Q  D        L  ER ++   R  + +   +
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRL 1583

Query: 278  TSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMK-NKCQELCCELEELQHHRQ---- 332
               + +  E +    + E QL RQ+ +    Q    K  + ++L  E EE Q HRQ    
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDR 1643

Query: 333  --VSEEEQ-RRLQRELKCAQNEVLRFQTSHSVTQ-NEELKSRLCTLQKKYDTS------Q 382
              + EE Q RR +RE +   +   +F+    + Q  EE + R     +K+         Q
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703

Query: 383  DEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLH--LQHQNVTCEKE--- 437
            + + + L+ + QL+ +  + K  +   +  ++E+E L R ++    L+ + +  E+E   
Sbjct: 1704 ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ 1763

Query: 438  -KLLERQQQLQEELQC-HEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDEL 495
             +  ER ++ +EE Q   E E Q LR   +  K   E+      + Q+++   +  K   
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRW 1823

Query: 496  ERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQK 555
            E ++   ++ EQ L   Q   ++ +A                         QEK +  ++
Sbjct: 1824 EEEQLQLEEQEQRLR--QERDRQYRAEEQF-------------------ATQEKSRREEQ 1862

Query: 556  EMGQLQMEQCELLEDQRRMQEE---QGQLQEELHR 587
            E+ Q + EQ    E +R+++EE   + Q +E+ HR
Sbjct: 1863 ELWQ-EEEQKRRQERERKLREEHIRRQQKEEQRHR 1896



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 158/825 (19%), Positives = 337/825 (40%), Gaps = 78/825 (9%)

Query: 309  QMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEV------LRFQTSHSVT 362
            Q  G+  + +  C   E L   R+  EE+QRR +   +  + E        R +    + 
Sbjct: 91   QATGLDEEKRARCDGKESLLQDRR-QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149

Query: 363  QNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELR----QLKVMKSTLVENQSEKEL 418
            + EE   +   L+++    +DE+    + + Q + E R    QL+  K    E   ++E 
Sbjct: 150  EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209

Query: 419  LCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETH 478
            L R + L L+ +     +EK  +R+++     Q  E +    R+TV   +E   ++ E  
Sbjct: 210  LRRRELLELRRKG---REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266

Query: 479  AQLQ---EMKQLYQASKDELERQKHMYDQLEQDLLL-CQLELKELKASHPIPEDKGKCAN 534
             Q +   E +QL +  + EL R++   +Q +Q L    QL  K+ +      E+      
Sbjct: 267  RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE------ 320

Query: 535  KCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPK 594
                   R  + + + +  ++   QL+ EQ E  E Q R ++E+ + +++L R      +
Sbjct: 321  -------RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373

Query: 595  SGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKES-- 652
               L + Q+L  + +   E QL  +     +++L + Q    ++QL   ++LRR +E   
Sbjct: 374  EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433

Query: 653  HFQEVLENPDDSKLAKSSK-----CNRNKQSKLLMEQMQALQVMYDAGQAKQE---LLQQ 704
            H Q+  +   + +L +  +       R ++++   ++ +  Q+  D  + ++E    L++
Sbjct: 434  HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493

Query: 705  EQGRLLEERK--RLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTY 762
            E+ R  +ER+  +L+ + +   E+    Q +   ++  L S  +         E   K  
Sbjct: 494  EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553

Query: 763  DTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTS 822
            +    + E   +     Q   +  L   +                        K      
Sbjct: 554  EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRL----------------KREQEER 597

Query: 823  SSDTCQKSFVSSCTDEEPAEPE-DMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQM 881
                 ++  V     EE  E     E  EE   + L+K +  +   Q  Q+   + QE+ 
Sbjct: 598  LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ--QQLRREQQERR 655

Query: 882  EKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMD 941
            E+ L ++++ +      +RE +E  E  E+ +A +  +   + +++++ + Q Q ++  D
Sbjct: 656  EQRLKREEEEERLEQRLKREHEE--ERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713

Query: 942  -EQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVT 1000
              Q ++     + EGQ +  ++E ++ R +     +E    +  +   +       +   
Sbjct: 714  ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773

Query: 1001 KPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEM----EEEKKQVKEEAKE 1056
            +  S+     L  R  L         QR+    A+E +++E+     EEEK+Q + + +E
Sbjct: 774  EEKSERGRQRLSARPPLR-------EQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826

Query: 1057 QCGDELVAEPADPEEAKSTEDQEENEED--KEEEEKEEDSEEEED 1099
            +  +    E  +  + +    Q + EED  +E++E+    E+  D
Sbjct: 827  REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 130/659 (19%), Positives = 267/659 (40%), Gaps = 70/659 (10%)

Query: 482  QEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKG-----KCANKC 536
            +++K L +     + R+ H  D    DL+L   EL +L ++  +  ++      K A  C
Sbjct: 31   KDLKNLLEREFGAVLRRPH--DPKTVDLIL---ELLDLDSNGRVDFNEFLLFIFKVAQAC 85

Query: 537  DTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSG 596
               L + T L E+ +A       L  ++ +  EDQRR +    QL+EE        P   
Sbjct: 86   YYALGQATGLDEEKRARCDGKESLLQDRRQE-EDQRRFEPRDRQLEEE--------PGQR 136

Query: 597  LLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQ- 655
               K QE   +L +  E Q   Q   E++ +  ++++   + Q     E RR +E   Q 
Sbjct: 137  RRQKRQEQERELAE-GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQS 195

Query: 656  ----EVLENPDDSKLAKSS------KCNRNKQSKLLMEQMQALQVMYDAGQAKQE-LLQQ 704
                E  E PD+ +L +        K    KQ +    Q +  Q   +    K+E +L++
Sbjct: 196  CKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRK 255

Query: 705  EQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDT 764
            E+ +L EE  + Q +LQ   EE QL +++   ++   +   +    +    +  RK  + 
Sbjct: 256  EEEKLQEEEPQRQRELQE--EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313

Query: 765  TVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSS 824
              +  E   +     +   +   +         E   +            ++        
Sbjct: 314  RREQQEERREQQERREQQEER--REQQLRREQEERREQQL----------RREQEEERRE 361

Query: 825  DTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQM--E 882
               ++       +++    + + R ++     L + Q ++   Q+ +E+  + ++Q+  E
Sbjct: 362  QQLRREQEEERREQQLRREQQLRREQQ-----LRREQQLRREQQLRREQQLRREQQLRRE 416

Query: 883  KLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDE 942
            + L +++ L+ E +    E K   E  E+ +  + ++ E ++   +  E +   Q    +
Sbjct: 417  QQLRREQQLRREQEEERHEQKHEQERREQRL--KREQEERRDWLKREEETERHEQERRKQ 474

Query: 943  QGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKP 1002
            Q +    +E+ E  L+  +EE R+ +E+R   ++  + +   + + +             
Sbjct: 475  QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE---------- 524

Query: 1003 CSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDEL 1062
                 E  L+ R   E  L  +  +R+   L +EEEK+ E E  ++++K E +E+    L
Sbjct: 525  -----EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579

Query: 1063 VAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
              E    ++    E +E  E+  + EE E   +EE  +     E PEE    +L +S++
Sbjct: 580  KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEE 638



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 55/312 (17%), Positives = 137/312 (43%), Gaps = 31/312 (9%)

Query: 838  EEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEK----LLAKQKDLKE 893
            E+    + ++R +E     L+K +  +   ++ +E+  +L++++++     L +++  ++
Sbjct: 559  EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618

Query: 894  ELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDE-QGRLLVVQEQ 952
             L   E E +   + L+     +  + +++  Q + RE +L+ +   +  + RL    E+
Sbjct: 619  RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678

Query: 953  LEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSE---- 1008
               + +  +EE  Q RE+  S + + + +     +   A+  + K  ++P     +    
Sbjct: 679  ERREQELAEEEQEQARERIKSRIPKWQWQ-----LESEADARQSKVYSRPRKQEGQRRRQ 733

Query: 1009 SDLETRKSLEVVLYYKASQRKLDGLAKEE-----------EKKEEMEEEKKQVKEEAKEQ 1057
               E R+  E  L ++  +R      +EE           E+K E   ++   +   +EQ
Sbjct: 734  EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793

Query: 1058 CGDELVAEPADPEEAKSTEDQEENEE------DKEEEEKEEDSEEEEDDADSSLESPEEN 1111
               +L AE     E +   ++EE E+      ++E+E +  + EE+    + + +  EE 
Sbjct: 794  RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE 853

Query: 1112 NPLRLSESKKSS 1123
            + L+  + ++ S
Sbjct: 854  DGLQEDQERRRS 865



 Score = 34.3 bits (77), Expect = 0.70
 Identities = 56/252 (22%), Positives = 95/252 (37%), Gaps = 29/252 (11%)

Query: 888  QKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLL 947
            +KDLK  L   EREF      L +P  P       K +   L  L L     +D    LL
Sbjct: 30   KKDLKNLL---EREFGAV---LRRPHDP-------KTVDLILELLDLDSNGRVDFNEFLL 76

Query: 948  VVQEQLE------GQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTK 1001
             + +  +      GQ     EE R   + + S++++ R +   +        ++ +   +
Sbjct: 77   FIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR 136

Query: 1002 PCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEE----KKEEMEEEKKQVKEEAKEQ 1057
                  E + E  +  E     +  +++ D   ++EE    ++E  E E+++ +EE  + 
Sbjct: 137  RRQKRQEQERELAEGEEQSEKQERLEQR-DRQRRDEELWRQRQEWQEREERRAEEEQLQS 195

Query: 1058 CGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPE---ENNPL 1114
            C      E  D E+ +  E  E     K  EEK++   E +D      E  E       L
Sbjct: 196  CKGHETEEFPDEEQLRRRELLELRR--KGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253

Query: 1115 RLSESKKSSPTP 1126
            R  E K     P
Sbjct: 254  RKEEEKLQEEEP 265


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  145 bits (366), Expect = 2e-34
 Identities = 229/1115 (20%), Positives = 458/1115 (41%), Gaps = 180/1115 (16%)

Query: 16   EEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEET 75
            +EEE + +E+E+++ +E+ QK                  E EL+EL  +  QL       
Sbjct: 850  QEEEMQAKEDELQKTKERQQK-----------------AENELKELEQKHSQLT------ 886

Query: 76   RELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESE 135
                   E + L+ Q   E E  A A++  V           L + ++E+  + HE E+ 
Sbjct: 887  ------EEKNLLQEQLQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEAR 930

Query: 136  LKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEME 195
            L+E E      QAE + + Q   D                  ++ +LE+ E  R   +++
Sbjct: 931  LEEEEDRGQQLQAERKKMAQQMLD------------------LEEQLEEEEAAR--QKLQ 970

Query: 196  IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLA 255
            +  + AE ++K               L++E+  + ++ + L++E + L+E  S LT  LA
Sbjct: 971  LEKVTAEAKIKK--------------LEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 256  DLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKN 315
            + E E+ +  T+  L+++  SM S      E+   + +   Q L +  R  E        
Sbjct: 1017 E-EEEKAKNLTK--LKNKHESMIS----ELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069

Query: 316  KCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQ 375
            +  +L  ++ EL+      EEE   LQ  L    +E+   Q ++++ +  EL+  +  LQ
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIA--QKNNALKKIRELEGHISDLQ 1124

Query: 376  KKYDTSQDEQNELLKMQLQLQTELRQLKV-MKSTLVENQSEKELLCRLQKLHLQHQNVTC 434
            +  D+ +  +N+  K +  L  EL  LK  ++ TL    +++EL  +      + Q VT 
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK------REQEVTV 1178

Query: 435  EKEKLLERQQQLQEELQCHEAELQHLR----DTVASFKESNEKDTETHAQLQEMKQLYQA 490
             K       + L EE + HEA++Q +R      V    E  E+     A L + KQ  + 
Sbjct: 1179 LK-------KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231

Query: 491  SKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCAN---KCDTLLSRLTELQ 547
               +L  +  +  Q +Q     ++E K+ K    + E + KC++       L  ++ +LQ
Sbjct: 1232 ENADLAGELRVLGQAKQ-----EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286

Query: 548  EKYKASQKEMGQLQMEQCELLED----QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQE 603
             + ++    + + + +  +L +D      ++Q+ Q  LQEE               +   
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-------------QKLN 1333

Query: 604  LLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDD 663
            + TKL  L           EE++  +Q+Q   L E++E  + L R   +   ++ ++   
Sbjct: 1334 VSTKLRQL-----------EEERNSLQDQ---LDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 664  SKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLC 723
             +   S+     +  K   ++++ L   Y+   A  + L++ + RL +E   L  DL   
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-- 1437

Query: 724  LEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSS 783
              + QL+         +LE   + +  ++   +N    Y    D+ +         +T +
Sbjct: 1438 -NQRQLVS--------NLEKKQRKFDQLLAEEKNISSKY---ADERDRAEAEAREKETKA 1485

Query: 784  KSFLKSYDSSTSASEAY---GKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP 840
             S  ++ + +  A E      K         ++ K   G         K  + +  +E  
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545

Query: 841  AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER 900
             + E++E  +E+      KL+    M  +  +    LQ + E+   K++ L+ +L   E 
Sbjct: 1546 TQLEELE--DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603

Query: 901  EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC 960
            E ++  E  ++ +A        K+L+  L++L+LQ  +++  +   +    +L+ Q++  
Sbjct: 1604 ELED--ERKQRALAAAAK----KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657

Query: 961  QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDT-SESDLETRKSLEV 1019
            Q EL   R  R  +   A+ +N  K  +  A+ +++++          ++DLE  +  E 
Sbjct: 1658 QRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716

Query: 1020 VLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGD-----ELVAEPADPEEAKS 1074
            +         L G    +++K  +E    Q++EE +E+ G+     + V +     E  S
Sbjct: 1717 L------ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770

Query: 1075 TEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPE 1109
             E   E    ++ E   +  E +  +  S L   E
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELRSKLHEME 1805



 Score =  136 bits (343), Expect = 1e-31
 Identities = 223/1099 (20%), Positives = 474/1099 (43%), Gaps = 156/1099 (14%)

Query: 51   LSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQ 110
            L +T  E EE++A+      EL++T+E   + E++  EL    E +     ++  +  +Q
Sbjct: 845  LQVTRQE-EEMQAKE----DELQKTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQ 895

Query: 111  IQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIAS 170
            +Q  + EL +  EE+ +    K+ EL+EI   LH  +A ++      ED   + +++   
Sbjct: 896  LQA-ETELYAEAEEMRVRLAAKKQELEEI---LHEMEARLEE----EEDRGQQLQAERKK 947

Query: 171  LQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELR 230
            + + +  ++ +LE+ E  R   ++E   + AE ++K               L++E+  + 
Sbjct: 948  MAQQMLDLEEQLEEEEAARQKLQLE--KVTAEAKIKK--------------LEDEILVMD 991

Query: 231  ERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFL 290
            ++ + L++E + L+E  S LT  LA+ E E+ +  T+  L+++  SM S      E+   
Sbjct: 992  DQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTK--LKNKHESMISE----LEVRLK 1044

Query: 291  EPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQN 350
            + +   Q L +  R  E        +  +L  ++ EL+      EEE   LQ  L    +
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDD 1101

Query: 351  EVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKV-MKSTL 409
            E+   Q ++++ +  EL+  +  LQ+  D+ +  +N+  K +  L  EL  LK  ++ TL
Sbjct: 1102 EIA--QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159

Query: 410  VENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRD----TVA 465
                +++EL  +      + Q VT  K+ L        EE + HEA++Q +R      V 
Sbjct: 1160 DSTATQQELRAK------REQEVTVLKKAL-------DEETRSHEAQVQEMRQKHAQAVE 1206

Query: 466  SFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPI 525
               E  E+     A L + KQ  +    +L  +  +  Q +Q++     E K+ K    +
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-----EHKKKKLEAQV 1261

Query: 526  PEDKGKCAN---KCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED----QRRMQEEQ 578
             E + KC++       L  ++ +LQ + ++    + + + +  +L +D      ++Q+ Q
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321

Query: 579  GQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKE 638
              LQEE  +                + TKL  L           EE++  +Q+Q   L E
Sbjct: 1322 ELLQEETRQ-------------KLNVSTKLRQL-----------EEERNSLQDQ---LDE 1354

Query: 639  QLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAK 698
            ++E  + L R   +   ++ ++    +   S+     +  K   ++++ L   Y+   A 
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414

Query: 699  QELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENC 758
             + L++ + RL +E   L  DL     + QL+         +LE   + +  ++   +N 
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLD---NQRQLVS--------NLEKKQRKFDQLLAEEKNI 1463

Query: 759  RKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAY---GKSYCTTSNSSITYK 815
               Y    D+ +         +T + S  ++ + +  A E      K         ++ K
Sbjct: 1464 SSKY---ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK 1520

Query: 816  KSYGSTSSSDTCQKSFVSSCTDEEPAEPEDME----RFEEMVVKVLIKLQAV-------- 863
               G         K  + +  +E   + E++E      E+  +++ + +QA+        
Sbjct: 1521 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580

Query: 864  QAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDK---- 919
            QA  + ++E+  QLQ Q+ +   + +D +++  A     K+ +E   K +  Q D     
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQR-ALAAAAKKKLEGDLKDLELQADSAIKG 1639

Query: 920  -----NEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLRE----- 969
                  ++++LQ ++++ Q + + +   +  +    ++ E + +  + +L QL+E     
Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699

Query: 970  ----KRPSVVKEARGKNANKNMN-KNANGVKMKKVTKPCSDTSESDLETRKSLEVVL--Y 1022
                K+  + KE   +    +++ +NA   + +++    +   E   E + ++E +    
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759

Query: 1023 YKASQRK---LDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQE 1079
             KA+Q+     + LA E    ++ E  ++Q++ + KE        E A   + KST    
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 1080 ENEEDKEEEEKEEDSEEEE 1098
            E +  + EE+ E+++ E++
Sbjct: 1820 EAKIAQLEEQVEQEAREKQ 1838



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 105/448 (23%), Positives = 200/448 (44%), Gaps = 67/448 (14%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVE--------EEEEQVQKGGSVGSLSVNKHRGLSL 53
            +A E E    +L    EE  E +EE+E        E E+ V     VG       +    
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536

Query: 54   TETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQ- 112
             ET++EE++ Q+ +L  EL+ T +   + E +   L+G  E +  A  +Q E   +Q+Q 
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596

Query: 113  ---QLQGELRSLREEISLLEHEK---ESELKEIE--------------QELHLAQAEIQS 152
               + + EL   R++ +L    K   E +LK++E              ++L   QA+++ 
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656

Query: 153  LRQAAED----------SATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAE 202
             ++  ED          +A E+E    SL+ DL ++Q +L   ER R   ++E   L  E
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716

Query: 203  MEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERT 262
            +         +  LS  + LQ+E + L  R   L EE   L+E   ++     +  S+R 
Sbjct: 1717 L---------ASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM-----EAMSDRV 1759

Query: 263  QRATERWLQ-SQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAE--------EQMHGM 313
            ++AT++  Q S  L+   + +Q +E    + + + + LR +L + E          +  +
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 314  KNKCQELCCELEELQHHRQVSEEEQRRLQRELK--CAQNEVLRFQTSHSVTQNEELKSRL 371
            + K  +L  ++E+    +Q + +  ++  ++LK    Q E  R        Q E+  +R+
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879

Query: 372  CTLQKKYDTSQDEQNELLKMQLQLQTEL 399
              L+++ + +++E   +   + +LQ EL
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQREL 1907



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 140/743 (18%), Positives = 308/743 (41%), Gaps = 96/743 (12%)

Query: 436  KEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDEL 495
            K K L +  + +EE+Q  E ELQ  ++     +   ++  + H+QL E K L Q   ++L
Sbjct: 840  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ---EQL 896

Query: 496  ERQKHMYDQLEQDLLLC-----QLE--LKELKASHPIPEDKG-KCANKCDTLLSRLTELQ 547
            + +  +Y + E+  +       +LE  L E++A     ED+G +   +   +  ++ +L+
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956

Query: 548  EKYKASQKEMGQLQME------QCELLEDQ--------RRMQEEQGQLQEELHRLTLPLP 593
            E+ +  +    +LQ+E      + + LED+         ++ +E+  L+E +  LT  L 
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 594  KSGLLLKSQELLTKLED-----LCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRR 648
            +     K+   LTKL++     + EL++  +  ++ +++L + +  +  +  + HE++  
Sbjct: 1017 EEEEKAKN---LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 649  F-------------KESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAG 695
                          KE   Q  L   DD    K+   N  K+ + L   +  LQ   D+ 
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKN---NALKKIRELEGHISDLQEDLDSE 1130

Query: 696  QAKQELLQQEQGRLLEERKRLQADLQLCL------EEMQLLQVQSPSI-KMSLESYGKSY 748
            +A +   ++++  L EE + L+ +L+  L      +E++  + Q  ++ K +L+   +S+
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190

Query: 749  GSMVPS-NENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTT 807
             + V    +   +  +   +  E + ++  +   + ++  K            G+     
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ----- 1245

Query: 808  SNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMY 867
            +   + +KK        +   +   S C+D E A  E      + V K+  ++++V  M 
Sbjct: 1246 AKQEVEHKK-----KKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGML 1296

Query: 868  QISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQT 927
              ++ +  +L + +  L ++ +D +E L                    Q +  +   + T
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELL--------------------QEETRQKLNVST 1336

Query: 928  KLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARG-KNANKN 986
            KLR+L+ +  +  D+    +  ++ LE  +     +L   ++K           +   K 
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETR--KSLEVVLYYKASQRKL-DGLAKEEEKKEEM 1043
              K    +  +   K  +       + R  + L+ ++    +QR+L   L K++ K +++
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456

Query: 1044 EEEKKQVKEE-AKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDAD 1102
              E+K +  + A E+   E  A   + +        EE  E KEE E+     + E +  
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 1103 SSLESPEENNPLRLSESKKSSPT 1125
             S +     N   L +SK++  T
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALET 1539


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  145 bits (366), Expect = 2e-34
 Identities = 229/1115 (20%), Positives = 458/1115 (41%), Gaps = 180/1115 (16%)

Query: 16   EEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEET 75
            +EEE + +E+E+++ +E+ QK                  E EL+EL  +  QL       
Sbjct: 857  QEEEMQAKEDELQKTKERQQK-----------------AENELKELEQKHSQLT------ 893

Query: 76   RELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESE 135
                   E + L+ Q   E E  A A++  V           L + ++E+  + HE E+ 
Sbjct: 894  ------EEKNLLQEQLQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEAR 937

Query: 136  LKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEME 195
            L+E E      QAE + + Q   D                  ++ +LE+ E  R   +++
Sbjct: 938  LEEEEDRGQQLQAERKKMAQQMLD------------------LEEQLEEEEAAR--QKLQ 977

Query: 196  IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLA 255
            +  + AE ++K               L++E+  + ++ + L++E + L+E  S LT  LA
Sbjct: 978  LEKVTAEAKIKK--------------LEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 256  DLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKN 315
            + E E+ +  T+  L+++  SM S      E+   + +   Q L +  R  E        
Sbjct: 1024 E-EEEKAKNLTK--LKNKHESMIS----ELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076

Query: 316  KCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQ 375
            +  +L  ++ EL+      EEE   LQ  L    +E+   Q ++++ +  EL+  +  LQ
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIA--QKNNALKKIRELEGHISDLQ 1131

Query: 376  KKYDTSQDEQNELLKMQLQLQTELRQLKV-MKSTLVENQSEKELLCRLQKLHLQHQNVTC 434
            +  D+ +  +N+  K +  L  EL  LK  ++ TL    +++EL  +      + Q VT 
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK------REQEVTV 1185

Query: 435  EKEKLLERQQQLQEELQCHEAELQHLR----DTVASFKESNEKDTETHAQLQEMKQLYQA 490
             K       + L EE + HEA++Q +R      V    E  E+     A L + KQ  + 
Sbjct: 1186 LK-------KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238

Query: 491  SKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCAN---KCDTLLSRLTELQ 547
               +L  +  +  Q +Q     ++E K+ K    + E + KC++       L  ++ +LQ
Sbjct: 1239 ENADLAGELRVLGQAKQ-----EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293

Query: 548  EKYKASQKEMGQLQMEQCELLED----QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQE 603
             + ++    + + + +  +L +D      ++Q+ Q  LQEE               +   
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-------------QKLN 1340

Query: 604  LLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDD 663
            + TKL  L           EE++  +Q+Q   L E++E  + L R   +   ++ ++   
Sbjct: 1341 VSTKLRQL-----------EEERNSLQDQ---LDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 664  SKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLC 723
             +   S+     +  K   ++++ L   Y+   A  + L++ + RL +E   L  DL   
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-- 1444

Query: 724  LEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSS 783
              + QL+         +LE   + +  ++   +N    Y    D+ +         +T +
Sbjct: 1445 -NQRQLVS--------NLEKKQRKFDQLLAEEKNISSKY---ADERDRAEAEAREKETKA 1492

Query: 784  KSFLKSYDSSTSASEAY---GKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP 840
             S  ++ + +  A E      K         ++ K   G         K  + +  +E  
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552

Query: 841  AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER 900
             + E++E  +E+      KL+    M  +  +    LQ + E+   K++ L+ +L   E 
Sbjct: 1553 TQLEELE--DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610

Query: 901  EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC 960
            E ++  E  ++ +A        K+L+  L++L+LQ  +++  +   +    +L+ Q++  
Sbjct: 1611 ELED--ERKQRALAAAAK----KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664

Query: 961  QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDT-SESDLETRKSLEV 1019
            Q EL   R  R  +   A+ +N  K  +  A+ +++++          ++DLE  +  E 
Sbjct: 1665 QRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723

Query: 1020 VLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGD-----ELVAEPADPEEAKS 1074
            +         L G    +++K  +E    Q++EE +E+ G+     + V +     E  S
Sbjct: 1724 L------ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 1075 TEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPE 1109
             E   E    ++ E   +  E +  +  S L   E
Sbjct: 1778 NELATERSTAQKNESARQQLERQNKELRSKLHEME 1812



 Score =  136 bits (343), Expect = 1e-31
 Identities = 223/1099 (20%), Positives = 474/1099 (43%), Gaps = 156/1099 (14%)

Query: 51   LSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQ 110
            L +T  E EE++A+      EL++T+E   + E++  EL    E +     ++  +  +Q
Sbjct: 852  LQVTRQE-EEMQAKE----DELQKTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQ 902

Query: 111  IQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIAS 170
            +Q  + EL +  EE+ +    K+ EL+EI   LH  +A ++      ED   + +++   
Sbjct: 903  LQA-ETELYAEAEEMRVRLAAKKQELEEI---LHEMEARLEE----EEDRGQQLQAERKK 954

Query: 171  LQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELR 230
            + + +  ++ +LE+ E  R   ++E   + AE ++K               L++E+  + 
Sbjct: 955  MAQQMLDLEEQLEEEEAARQKLQLE--KVTAEAKIKK--------------LEDEILVMD 998

Query: 231  ERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFL 290
            ++ + L++E + L+E  S LT  LA+ E E+ +  T+  L+++  SM S      E+   
Sbjct: 999  DQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTK--LKNKHESMISE----LEVRLK 1051

Query: 291  EPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQN 350
            + +   Q L +  R  E        +  +L  ++ EL+      EEE   LQ  L    +
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDD 1108

Query: 351  EVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKV-MKSTL 409
            E+   Q ++++ +  EL+  +  LQ+  D+ +  +N+  K +  L  EL  LK  ++ TL
Sbjct: 1109 EIA--QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166

Query: 410  VENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRD----TVA 465
                +++EL  +      + Q VT  K+ L        EE + HEA++Q +R      V 
Sbjct: 1167 DSTATQQELRAK------REQEVTVLKKAL-------DEETRSHEAQVQEMRQKHAQAVE 1213

Query: 466  SFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPI 525
               E  E+     A L + KQ  +    +L  +  +  Q +Q++     E K+ K    +
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-----EHKKKKLEAQV 1268

Query: 526  PEDKGKCAN---KCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED----QRRMQEEQ 578
             E + KC++       L  ++ +LQ + ++    + + + +  +L +D      ++Q+ Q
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328

Query: 579  GQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKE 638
              LQEE  +                + TKL  L           EE++  +Q+Q   L E
Sbjct: 1329 ELLQEETRQ-------------KLNVSTKLRQL-----------EEERNSLQDQ---LDE 1361

Query: 639  QLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAK 698
            ++E  + L R   +   ++ ++    +   S+     +  K   ++++ L   Y+   A 
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421

Query: 699  QELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENC 758
             + L++ + RL +E   L  DL     + QL+         +LE   + +  ++   +N 
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLD---NQRQLVS--------NLEKKQRKFDQLLAEEKNI 1470

Query: 759  RKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAY---GKSYCTTSNSSITYK 815
               Y    D+ +         +T + S  ++ + +  A E      K         ++ K
Sbjct: 1471 SSKY---ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK 1527

Query: 816  KSYGSTSSSDTCQKSFVSSCTDEEPAEPEDME----RFEEMVVKVLIKLQAV-------- 863
               G         K  + +  +E   + E++E      E+  +++ + +QA+        
Sbjct: 1528 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587

Query: 864  QAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDK---- 919
            QA  + ++E+  QLQ Q+ +   + +D +++  A     K+ +E   K +  Q D     
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQR-ALAAAAKKKLEGDLKDLELQADSAIKG 1646

Query: 920  -----NEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLRE----- 969
                  ++++LQ ++++ Q + + +   +  +    ++ E + +  + +L QL+E     
Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706

Query: 970  ----KRPSVVKEARGKNANKNMN-KNANGVKMKKVTKPCSDTSESDLETRKSLEVVL--Y 1022
                K+  + KE   +    +++ +NA   + +++    +   E   E + ++E +    
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766

Query: 1023 YKASQRK---LDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQE 1079
             KA+Q+     + LA E    ++ E  ++Q++ + KE        E A   + KST    
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 1080 ENEEDKEEEEKEEDSEEEE 1098
            E +  + EE+ E+++ E++
Sbjct: 1827 EAKIAQLEEQVEQEAREKQ 1845



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 105/448 (23%), Positives = 200/448 (44%), Gaps = 67/448 (14%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVE--------EEEEQVQKGGSVGSLSVNKHRGLSL 53
            +A E E    +L    EE  E +EE+E        E E+ V     VG       +    
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543

Query: 54   TETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQ- 112
             ET++EE++ Q+ +L  EL+ T +   + E +   L+G  E +  A  +Q E   +Q+Q 
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603

Query: 113  ---QLQGELRSLREEISLLEHEK---ESELKEIE--------------QELHLAQAEIQS 152
               + + EL   R++ +L    K   E +LK++E              ++L   QA+++ 
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663

Query: 153  LRQAAED----------SATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAE 202
             ++  ED          +A E+E    SL+ DL ++Q +L   ER R   ++E   L  E
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723

Query: 203  MEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERT 262
            +         +  LS  + LQ+E + L  R   L EE   L+E   ++     +  S+R 
Sbjct: 1724 L---------ASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM-----EAMSDRV 1766

Query: 263  QRATERWLQ-SQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAE--------EQMHGM 313
            ++AT++  Q S  L+   + +Q +E    + + + + LR +L + E          +  +
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 314  KNKCQELCCELEELQHHRQVSEEEQRRLQRELK--CAQNEVLRFQTSHSVTQNEELKSRL 371
            + K  +L  ++E+    +Q + +  ++  ++LK    Q E  R        Q E+  +R+
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886

Query: 372  CTLQKKYDTSQDEQNELLKMQLQLQTEL 399
              L+++ + +++E   +   + +LQ EL
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQREL 1914



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 140/743 (18%), Positives = 308/743 (41%), Gaps = 96/743 (12%)

Query: 436  KEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDEL 495
            K K L +  + +EE+Q  E ELQ  ++     +   ++  + H+QL E K L Q   ++L
Sbjct: 847  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ---EQL 903

Query: 496  ERQKHMYDQLEQDLLLC-----QLE--LKELKASHPIPEDKG-KCANKCDTLLSRLTELQ 547
            + +  +Y + E+  +       +LE  L E++A     ED+G +   +   +  ++ +L+
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963

Query: 548  EKYKASQKEMGQLQME------QCELLEDQ--------RRMQEEQGQLQEELHRLTLPLP 593
            E+ +  +    +LQ+E      + + LED+         ++ +E+  L+E +  LT  L 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 594  KSGLLLKSQELLTKLED-----LCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRR 648
            +     K+   LTKL++     + EL++  +  ++ +++L + +  +  +  + HE++  
Sbjct: 1024 EEEEKAKN---LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 649  F-------------KESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAG 695
                          KE   Q  L   DD    K+   N  K+ + L   +  LQ   D+ 
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKN---NALKKIRELEGHISDLQEDLDSE 1137

Query: 696  QAKQELLQQEQGRLLEERKRLQADLQLCL------EEMQLLQVQSPSI-KMSLESYGKSY 748
            +A +   ++++  L EE + L+ +L+  L      +E++  + Q  ++ K +L+   +S+
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197

Query: 749  GSMVPS-NENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTT 807
             + V    +   +  +   +  E + ++  +   + ++  K            G+     
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ----- 1252

Query: 808  SNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMY 867
            +   + +KK        +   +   S C+D E A  E      + V K+  ++++V  M 
Sbjct: 1253 AKQEVEHKK-----KKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGML 1303

Query: 868  QISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQT 927
              ++ +  +L + +  L ++ +D +E L                    Q +  +   + T
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELL--------------------QEETRQKLNVST 1343

Query: 928  KLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARG-KNANKN 986
            KLR+L+ +  +  D+    +  ++ LE  +     +L   ++K           +   K 
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETR--KSLEVVLYYKASQRKL-DGLAKEEEKKEEM 1043
              K    +  +   K  +       + R  + L+ ++    +QR+L   L K++ K +++
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463

Query: 1044 EEEKKQVKEE-AKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDAD 1102
              E+K +  + A E+   E  A   + +        EE  E KEE E+     + E +  
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 1103 SSLESPEENNPLRLSESKKSSPT 1125
             S +     N   L +SK++  T
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALET 1546


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  145 bits (366), Expect = 2e-34
 Identities = 229/1115 (20%), Positives = 458/1115 (41%), Gaps = 180/1115 (16%)

Query: 16   EEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEET 75
            +EEE + +E+E+++ +E+ QK                  E EL+EL  +  QL       
Sbjct: 857  QEEEMQAKEDELQKTKERQQK-----------------AENELKELEQKHSQLT------ 893

Query: 76   RELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESE 135
                   E + L+ Q   E E  A A++  V           L + ++E+  + HE E+ 
Sbjct: 894  ------EEKNLLQEQLQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEAR 937

Query: 136  LKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEME 195
            L+E E      QAE + + Q   D                  ++ +LE+ E  R   +++
Sbjct: 938  LEEEEDRGQQLQAERKKMAQQMLD------------------LEEQLEEEEAAR--QKLQ 977

Query: 196  IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLA 255
            +  + AE ++K               L++E+  + ++ + L++E + L+E  S LT  LA
Sbjct: 978  LEKVTAEAKIKK--------------LEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 256  DLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKN 315
            + E E+ +  T+  L+++  SM S      E+   + +   Q L +  R  E        
Sbjct: 1024 E-EEEKAKNLTK--LKNKHESMIS----ELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076

Query: 316  KCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQ 375
            +  +L  ++ EL+      EEE   LQ  L    +E+   Q ++++ +  EL+  +  LQ
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIA--QKNNALKKIRELEGHISDLQ 1131

Query: 376  KKYDTSQDEQNELLKMQLQLQTELRQLKV-MKSTLVENQSEKELLCRLQKLHLQHQNVTC 434
            +  D+ +  +N+  K +  L  EL  LK  ++ TL    +++EL  +      + Q VT 
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK------REQEVTV 1185

Query: 435  EKEKLLERQQQLQEELQCHEAELQHLR----DTVASFKESNEKDTETHAQLQEMKQLYQA 490
             K       + L EE + HEA++Q +R      V    E  E+     A L + KQ  + 
Sbjct: 1186 LK-------KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238

Query: 491  SKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCAN---KCDTLLSRLTELQ 547
               +L  +  +  Q +Q     ++E K+ K    + E + KC++       L  ++ +LQ
Sbjct: 1239 ENADLAGELRVLGQAKQ-----EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293

Query: 548  EKYKASQKEMGQLQMEQCELLED----QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQE 603
             + ++    + + + +  +L +D      ++Q+ Q  LQEE               +   
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-------------QKLN 1340

Query: 604  LLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDD 663
            + TKL  L           EE++  +Q+Q   L E++E  + L R   +   ++ ++   
Sbjct: 1341 VSTKLRQL-----------EEERNSLQDQ---LDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 664  SKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLC 723
             +   S+     +  K   ++++ L   Y+   A  + L++ + RL +E   L  DL   
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-- 1444

Query: 724  LEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSS 783
              + QL+         +LE   + +  ++   +N    Y    D+ +         +T +
Sbjct: 1445 -NQRQLVS--------NLEKKQRKFDQLLAEEKNISSKY---ADERDRAEAEAREKETKA 1492

Query: 784  KSFLKSYDSSTSASEAY---GKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP 840
             S  ++ + +  A E      K         ++ K   G         K  + +  +E  
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552

Query: 841  AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER 900
             + E++E  +E+      KL+    M  +  +    LQ + E+   K++ L+ +L   E 
Sbjct: 1553 TQLEELE--DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610

Query: 901  EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC 960
            E ++  E  ++ +A        K+L+  L++L+LQ  +++  +   +    +L+ Q++  
Sbjct: 1611 ELED--ERKQRALAAAAK----KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664

Query: 961  QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDT-SESDLETRKSLEV 1019
            Q EL   R  R  +   A+ +N  K  +  A+ +++++          ++DLE  +  E 
Sbjct: 1665 QRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723

Query: 1020 VLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGD-----ELVAEPADPEEAKS 1074
            +         L G    +++K  +E    Q++EE +E+ G+     + V +     E  S
Sbjct: 1724 L------ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777

Query: 1075 TEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPE 1109
             E   E    ++ E   +  E +  +  S L   E
Sbjct: 1778 NELATERSTAQKNESARQQLERQNKELRSKLHEME 1812



 Score =  136 bits (343), Expect = 1e-31
 Identities = 223/1099 (20%), Positives = 474/1099 (43%), Gaps = 156/1099 (14%)

Query: 51   LSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQ 110
            L +T  E EE++A+      EL++T+E   + E++  EL    E +     ++  +  +Q
Sbjct: 852  LQVTRQE-EEMQAKE----DELQKTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQ 902

Query: 111  IQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIAS 170
            +Q  + EL +  EE+ +    K+ EL+EI   LH  +A ++      ED   + +++   
Sbjct: 903  LQA-ETELYAEAEEMRVRLAAKKQELEEI---LHEMEARLEE----EEDRGQQLQAERKK 954

Query: 171  LQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELR 230
            + + +  ++ +LE+ E  R   ++E   + AE ++K               L++E+  + 
Sbjct: 955  MAQQMLDLEEQLEEEEAARQKLQLE--KVTAEAKIKK--------------LEDEILVMD 998

Query: 231  ERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFL 290
            ++ + L++E + L+E  S LT  LA+ E E+ +  T+  L+++  SM S      E+   
Sbjct: 999  DQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTK--LKNKHESMISE----LEVRLK 1051

Query: 291  EPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQN 350
            + +   Q L +  R  E        +  +L  ++ EL+      EEE   LQ  L    +
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDD 1108

Query: 351  EVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKV-MKSTL 409
            E+   Q ++++ +  EL+  +  LQ+  D+ +  +N+  K +  L  EL  LK  ++ TL
Sbjct: 1109 EIA--QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166

Query: 410  VENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRD----TVA 465
                +++EL  +      + Q VT  K+ L        EE + HEA++Q +R      V 
Sbjct: 1167 DSTATQQELRAK------REQEVTVLKKAL-------DEETRSHEAQVQEMRQKHAQAVE 1213

Query: 466  SFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPI 525
               E  E+     A L + KQ  +    +L  +  +  Q +Q++     E K+ K    +
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-----EHKKKKLEAQV 1268

Query: 526  PEDKGKCAN---KCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED----QRRMQEEQ 578
             E + KC++       L  ++ +LQ + ++    + + + +  +L +D      ++Q+ Q
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328

Query: 579  GQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKE 638
              LQEE  +                + TKL  L           EE++  +Q+Q   L E
Sbjct: 1329 ELLQEETRQ-------------KLNVSTKLRQL-----------EEERNSLQDQ---LDE 1361

Query: 639  QLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAK 698
            ++E  + L R   +   ++ ++    +   S+     +  K   ++++ L   Y+   A 
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421

Query: 699  QELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENC 758
             + L++ + RL +E   L  DL     + QL+         +LE   + +  ++   +N 
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLD---NQRQLVS--------NLEKKQRKFDQLLAEEKNI 1470

Query: 759  RKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAY---GKSYCTTSNSSITYK 815
               Y    D+ +         +T + S  ++ + +  A E      K         ++ K
Sbjct: 1471 SSKY---ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK 1527

Query: 816  KSYGSTSSSDTCQKSFVSSCTDEEPAEPEDME----RFEEMVVKVLIKLQAV-------- 863
               G         K  + +  +E   + E++E      E+  +++ + +QA+        
Sbjct: 1528 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587

Query: 864  QAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDK---- 919
            QA  + ++E+  QLQ Q+ +   + +D +++  A     K+ +E   K +  Q D     
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQR-ALAAAAKKKLEGDLKDLELQADSAIKG 1646

Query: 920  -----NEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLRE----- 969
                  ++++LQ ++++ Q + + +   +  +    ++ E + +  + +L QL+E     
Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706

Query: 970  ----KRPSVVKEARGKNANKNMN-KNANGVKMKKVTKPCSDTSESDLETRKSLEVVL--Y 1022
                K+  + KE   +    +++ +NA   + +++    +   E   E + ++E +    
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766

Query: 1023 YKASQRK---LDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQE 1079
             KA+Q+     + LA E    ++ E  ++Q++ + KE        E A   + KST    
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 1080 ENEEDKEEEEKEEDSEEEE 1098
            E +  + EE+ E+++ E++
Sbjct: 1827 EAKIAQLEEQVEQEAREKQ 1845



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 105/448 (23%), Positives = 200/448 (44%), Gaps = 67/448 (14%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVE--------EEEEQVQKGGSVGSLSVNKHRGLSL 53
            +A E E    +L    EE  E +EE+E        E E+ V     VG       +    
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543

Query: 54   TETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQ- 112
             ET++EE++ Q+ +L  EL+ T +   + E +   L+G  E +  A  +Q E   +Q+Q 
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603

Query: 113  ---QLQGELRSLREEISLLEHEK---ESELKEIE--------------QELHLAQAEIQS 152
               + + EL   R++ +L    K   E +LK++E              ++L   QA+++ 
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663

Query: 153  LRQAAED----------SATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAE 202
             ++  ED          +A E+E    SL+ DL ++Q +L   ER R   ++E   L  E
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723

Query: 203  MEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERT 262
            +         +  LS  + LQ+E + L  R   L EE   L+E   ++     +  S+R 
Sbjct: 1724 L---------ASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM-----EAMSDRV 1766

Query: 263  QRATERWLQ-SQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAE--------EQMHGM 313
            ++AT++  Q S  L+   + +Q +E    + + + + LR +L + E          +  +
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 314  KNKCQELCCELEELQHHRQVSEEEQRRLQRELK--CAQNEVLRFQTSHSVTQNEELKSRL 371
            + K  +L  ++E+    +Q + +  ++  ++LK    Q E  R        Q E+  +R+
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886

Query: 372  CTLQKKYDTSQDEQNELLKMQLQLQTEL 399
              L+++ + +++E   +   + +LQ EL
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQREL 1914



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 140/743 (18%), Positives = 308/743 (41%), Gaps = 96/743 (12%)

Query: 436  KEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDEL 495
            K K L +  + +EE+Q  E ELQ  ++     +   ++  + H+QL E K L Q   ++L
Sbjct: 847  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ---EQL 903

Query: 496  ERQKHMYDQLEQDLLLC-----QLE--LKELKASHPIPEDKG-KCANKCDTLLSRLTELQ 547
            + +  +Y + E+  +       +LE  L E++A     ED+G +   +   +  ++ +L+
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963

Query: 548  EKYKASQKEMGQLQME------QCELLEDQ--------RRMQEEQGQLQEELHRLTLPLP 593
            E+ +  +    +LQ+E      + + LED+         ++ +E+  L+E +  LT  L 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 594  KSGLLLKSQELLTKLED-----LCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRR 648
            +     K+   LTKL++     + EL++  +  ++ +++L + +  +  +  + HE++  
Sbjct: 1024 EEEEKAKN---LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 649  F-------------KESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAG 695
                          KE   Q  L   DD    K+   N  K+ + L   +  LQ   D+ 
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKN---NALKKIRELEGHISDLQEDLDSE 1137

Query: 696  QAKQELLQQEQGRLLEERKRLQADLQLCL------EEMQLLQVQSPSI-KMSLESYGKSY 748
            +A +   ++++  L EE + L+ +L+  L      +E++  + Q  ++ K +L+   +S+
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197

Query: 749  GSMVPS-NENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTT 807
             + V    +   +  +   +  E + ++  +   + ++  K            G+     
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ----- 1252

Query: 808  SNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMY 867
            +   + +KK        +   +   S C+D E A  E      + V K+  ++++V  M 
Sbjct: 1253 AKQEVEHKK-----KKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGML 1303

Query: 868  QISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQT 927
              ++ +  +L + +  L ++ +D +E L                    Q +  +   + T
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELL--------------------QEETRQKLNVST 1343

Query: 928  KLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARG-KNANKN 986
            KLR+L+ +  +  D+    +  ++ LE  +     +L   ++K           +   K 
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETR--KSLEVVLYYKASQRKL-DGLAKEEEKKEEM 1043
              K    +  +   K  +       + R  + L+ ++    +QR+L   L K++ K +++
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463

Query: 1044 EEEKKQVKEE-AKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDAD 1102
              E+K +  + A E+   E  A   + +        EE  E KEE E+     + E +  
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 1103 SSLESPEENNPLRLSESKKSSPT 1125
             S +     N   L +SK++  T
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALET 1546



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 93/383 (24%), Positives = 175/383 (45%), Gaps = 59/383 (15%)

Query: 1    MQAMEGEVLLPALYEEEEEEEEEEE------EVEEEEEQVQKGGSVGSLSVNKHRGLSLT 54
            MQA++G+        +E+ EE+  +      E E E E  +K  ++ + +  K  G    
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG---- 1631

Query: 55   ETELEELRAQVLQLVAELEET----RELAGQHEDDSLELQGLL--EDERLASAQQAEVFT 108
              +L++L  Q    +   EE     R+L  Q +D   EL+      DE  A+A++ E   
Sbjct: 1632 --DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE--- 1686

Query: 109  KQIQQLQGELRSLREEISLLEHEKES---ELKEIEQELHLAQAEIQSLRQAAEDSATEHE 165
            K+ + L+ +L  L+E+++  E  ++    E +E+ +EL    A   S R A +D     E
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL----ASSLSGRNALQDEKRRLE 1742

Query: 166  SDIASLQEDLCRMQNELEDM-ERIRGDYEMEIASLRAEM---EMKSSEPSGSLGLSDYSG 221
            + IA L+E+L   Q  +E M +R+R       A+ +AE    E+ +   +     S    
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRK------ATQQAEQLSNELATERSTAQKNESARQQ 1796

Query: 222  LQEELQELRERYHFLNEEYRALQESN-SSLTGQLADLESERTQRATERWLQSQTLSMTSA 280
            L+ + +ELR + H +    ++  +S  ++L  ++A LE +  Q A E+  Q+ T S+   
Sbjct: 1797 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK--QAATKSLKQK 1854

Query: 281  ESQTSEMDFLEPDPEMQL-----------------LRQQLRDAEEQMHGMKNKCQELCCE 323
            + +  E+  L+ + E ++                 L++QL +AEE+   +    ++L  E
Sbjct: 1855 DKKLKEI-LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913

Query: 324  LEELQHHRQVSEEEQRRLQRELK 346
            L+E     +    E   L+ +L+
Sbjct: 1914 LDEATESNEAMGREVNALKSKLR 1936


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  145 bits (366), Expect = 2e-34
 Identities = 229/1115 (20%), Positives = 458/1115 (41%), Gaps = 180/1115 (16%)

Query: 16   EEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEET 75
            +EEE + +E+E+++ +E+ QK                  E EL+EL  +  QL       
Sbjct: 850  QEEEMQAKEDELQKTKERQQK-----------------AENELKELEQKHSQLT------ 886

Query: 76   RELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESE 135
                   E + L+ Q   E E  A A++  V           L + ++E+  + HE E+ 
Sbjct: 887  ------EEKNLLQEQLQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEAR 930

Query: 136  LKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEME 195
            L+E E      QAE + + Q   D                  ++ +LE+ E  R   +++
Sbjct: 931  LEEEEDRGQQLQAERKKMAQQMLD------------------LEEQLEEEEAAR--QKLQ 970

Query: 196  IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLA 255
            +  + AE ++K               L++E+  + ++ + L++E + L+E  S LT  LA
Sbjct: 971  LEKVTAEAKIKK--------------LEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 256  DLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKN 315
            + E E+ +  T+  L+++  SM S      E+   + +   Q L +  R  E        
Sbjct: 1017 E-EEEKAKNLTK--LKNKHESMIS----ELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069

Query: 316  KCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQ 375
            +  +L  ++ EL+      EEE   LQ  L    +E+   Q ++++ +  EL+  +  LQ
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIA--QKNNALKKIRELEGHISDLQ 1124

Query: 376  KKYDTSQDEQNELLKMQLQLQTELRQLKV-MKSTLVENQSEKELLCRLQKLHLQHQNVTC 434
            +  D+ +  +N+  K +  L  EL  LK  ++ TL    +++EL  +      + Q VT 
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK------REQEVTV 1178

Query: 435  EKEKLLERQQQLQEELQCHEAELQHLR----DTVASFKESNEKDTETHAQLQEMKQLYQA 490
             K       + L EE + HEA++Q +R      V    E  E+     A L + KQ  + 
Sbjct: 1179 LK-------KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231

Query: 491  SKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCAN---KCDTLLSRLTELQ 547
               +L  +  +  Q +Q     ++E K+ K    + E + KC++       L  ++ +LQ
Sbjct: 1232 ENADLAGELRVLGQAKQ-----EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286

Query: 548  EKYKASQKEMGQLQMEQCELLED----QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQE 603
             + ++    + + + +  +L +D      ++Q+ Q  LQEE               +   
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-------------QKLN 1333

Query: 604  LLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDD 663
            + TKL  L           EE++  +Q+Q   L E++E  + L R   +   ++ ++   
Sbjct: 1334 VSTKLRQL-----------EEERNSLQDQ---LDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 664  SKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLC 723
             +   S+     +  K   ++++ L   Y+   A  + L++ + RL +E   L  DL   
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-- 1437

Query: 724  LEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSS 783
              + QL+         +LE   + +  ++   +N    Y    D+ +         +T +
Sbjct: 1438 -NQRQLVS--------NLEKKQRKFDQLLAEEKNISSKY---ADERDRAEAEAREKETKA 1485

Query: 784  KSFLKSYDSSTSASEAY---GKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP 840
             S  ++ + +  A E      K         ++ K   G         K  + +  +E  
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545

Query: 841  AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER 900
             + E++E  +E+      KL+    M  +  +    LQ + E+   K++ L+ +L   E 
Sbjct: 1546 TQLEELE--DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603

Query: 901  EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC 960
            E ++  E  ++ +A        K+L+  L++L+LQ  +++  +   +    +L+ Q++  
Sbjct: 1604 ELED--ERKQRALAAAAK----KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657

Query: 961  QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDT-SESDLETRKSLEV 1019
            Q EL   R  R  +   A+ +N  K  +  A+ +++++          ++DLE  +  E 
Sbjct: 1658 QRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716

Query: 1020 VLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGD-----ELVAEPADPEEAKS 1074
            +         L G    +++K  +E    Q++EE +E+ G+     + V +     E  S
Sbjct: 1717 L------ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770

Query: 1075 TEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPE 1109
             E   E    ++ E   +  E +  +  S L   E
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELRSKLHEME 1805



 Score =  136 bits (343), Expect = 1e-31
 Identities = 223/1099 (20%), Positives = 474/1099 (43%), Gaps = 156/1099 (14%)

Query: 51   LSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQ 110
            L +T  E EE++A+      EL++T+E   + E++  EL    E +     ++  +  +Q
Sbjct: 845  LQVTRQE-EEMQAKE----DELQKTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQ 895

Query: 111  IQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIAS 170
            +Q  + EL +  EE+ +    K+ EL+EI   LH  +A ++      ED   + +++   
Sbjct: 896  LQA-ETELYAEAEEMRVRLAAKKQELEEI---LHEMEARLEE----EEDRGQQLQAERKK 947

Query: 171  LQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELR 230
            + + +  ++ +LE+ E  R   ++E   + AE ++K               L++E+  + 
Sbjct: 948  MAQQMLDLEEQLEEEEAARQKLQLE--KVTAEAKIKK--------------LEDEILVMD 991

Query: 231  ERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFL 290
            ++ + L++E + L+E  S LT  LA+ E E+ +  T+  L+++  SM S      E+   
Sbjct: 992  DQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTK--LKNKHESMISE----LEVRLK 1044

Query: 291  EPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQN 350
            + +   Q L +  R  E        +  +L  ++ EL+      EEE   LQ  L    +
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDD 1101

Query: 351  EVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKV-MKSTL 409
            E+   Q ++++ +  EL+  +  LQ+  D+ +  +N+  K +  L  EL  LK  ++ TL
Sbjct: 1102 EIA--QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159

Query: 410  VENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRD----TVA 465
                +++EL  +      + Q VT  K+ L        EE + HEA++Q +R      V 
Sbjct: 1160 DSTATQQELRAK------REQEVTVLKKAL-------DEETRSHEAQVQEMRQKHAQAVE 1206

Query: 466  SFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPI 525
               E  E+     A L + KQ  +    +L  +  +  Q +Q++     E K+ K    +
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-----EHKKKKLEAQV 1261

Query: 526  PEDKGKCAN---KCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED----QRRMQEEQ 578
             E + KC++       L  ++ +LQ + ++    + + + +  +L +D      ++Q+ Q
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321

Query: 579  GQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKE 638
              LQEE  +                + TKL  L           EE++  +Q+Q   L E
Sbjct: 1322 ELLQEETRQ-------------KLNVSTKLRQL-----------EEERNSLQDQ---LDE 1354

Query: 639  QLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAK 698
            ++E  + L R   +   ++ ++    +   S+     +  K   ++++ L   Y+   A 
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414

Query: 699  QELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENC 758
             + L++ + RL +E   L  DL     + QL+         +LE   + +  ++   +N 
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLD---NQRQLVS--------NLEKKQRKFDQLLAEEKNI 1463

Query: 759  RKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAY---GKSYCTTSNSSITYK 815
               Y    D+ +         +T + S  ++ + +  A E      K         ++ K
Sbjct: 1464 SSKY---ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK 1520

Query: 816  KSYGSTSSSDTCQKSFVSSCTDEEPAEPEDME----RFEEMVVKVLIKLQAV-------- 863
               G         K  + +  +E   + E++E      E+  +++ + +QA+        
Sbjct: 1521 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580

Query: 864  QAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDK---- 919
            QA  + ++E+  QLQ Q+ +   + +D +++  A     K+ +E   K +  Q D     
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQR-ALAAAAKKKLEGDLKDLELQADSAIKG 1639

Query: 920  -----NEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLRE----- 969
                  ++++LQ ++++ Q + + +   +  +    ++ E + +  + +L QL+E     
Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699

Query: 970  ----KRPSVVKEARGKNANKNMN-KNANGVKMKKVTKPCSDTSESDLETRKSLEVVL--Y 1022
                K+  + KE   +    +++ +NA   + +++    +   E   E + ++E +    
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759

Query: 1023 YKASQRK---LDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQE 1079
             KA+Q+     + LA E    ++ E  ++Q++ + KE        E A   + KST    
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 1080 ENEEDKEEEEKEEDSEEEE 1098
            E +  + EE+ E+++ E++
Sbjct: 1820 EAKIAQLEEQVEQEAREKQ 1838



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 105/448 (23%), Positives = 200/448 (44%), Gaps = 67/448 (14%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVE--------EEEEQVQKGGSVGSLSVNKHRGLSL 53
            +A E E    +L    EE  E +EE+E        E E+ V     VG       +    
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536

Query: 54   TETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQ- 112
             ET++EE++ Q+ +L  EL+ T +   + E +   L+G  E +  A  +Q E   +Q+Q 
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596

Query: 113  ---QLQGELRSLREEISLLEHEK---ESELKEIE--------------QELHLAQAEIQS 152
               + + EL   R++ +L    K   E +LK++E              ++L   QA+++ 
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656

Query: 153  LRQAAED----------SATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAE 202
             ++  ED          +A E+E    SL+ DL ++Q +L   ER R   ++E   L  E
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716

Query: 203  MEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERT 262
            +         +  LS  + LQ+E + L  R   L EE   L+E   ++     +  S+R 
Sbjct: 1717 L---------ASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNM-----EAMSDRV 1759

Query: 263  QRATERWLQ-SQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAE--------EQMHGM 313
            ++AT++  Q S  L+   + +Q +E    + + + + LR +L + E          +  +
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 314  KNKCQELCCELEELQHHRQVSEEEQRRLQRELK--CAQNEVLRFQTSHSVTQNEELKSRL 371
            + K  +L  ++E+    +Q + +  ++  ++LK    Q E  R        Q E+  +R+
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879

Query: 372  CTLQKKYDTSQDEQNELLKMQLQLQTEL 399
              L+++ + +++E   +   + +LQ EL
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQREL 1907



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 140/743 (18%), Positives = 308/743 (41%), Gaps = 96/743 (12%)

Query: 436  KEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDEL 495
            K K L +  + +EE+Q  E ELQ  ++     +   ++  + H+QL E K L Q   ++L
Sbjct: 840  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ---EQL 896

Query: 496  ERQKHMYDQLEQDLLLC-----QLE--LKELKASHPIPEDKG-KCANKCDTLLSRLTELQ 547
            + +  +Y + E+  +       +LE  L E++A     ED+G +   +   +  ++ +L+
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956

Query: 548  EKYKASQKEMGQLQME------QCELLEDQ--------RRMQEEQGQLQEELHRLTLPLP 593
            E+ +  +    +LQ+E      + + LED+         ++ +E+  L+E +  LT  L 
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 594  KSGLLLKSQELLTKLED-----LCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRR 648
            +     K+   LTKL++     + EL++  +  ++ +++L + +  +  +  + HE++  
Sbjct: 1017 EEEEKAKN---LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 649  F-------------KESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAG 695
                          KE   Q  L   DD    K+   N  K+ + L   +  LQ   D+ 
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKN---NALKKIRELEGHISDLQEDLDSE 1130

Query: 696  QAKQELLQQEQGRLLEERKRLQADLQLCL------EEMQLLQVQSPSI-KMSLESYGKSY 748
            +A +   ++++  L EE + L+ +L+  L      +E++  + Q  ++ K +L+   +S+
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190

Query: 749  GSMVPS-NENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTT 807
             + V    +   +  +   +  E + ++  +   + ++  K            G+     
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ----- 1245

Query: 808  SNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMY 867
            +   + +KK        +   +   S C+D E A  E      + V K+  ++++V  M 
Sbjct: 1246 AKQEVEHKK-----KKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGML 1296

Query: 868  QISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQT 927
              ++ +  +L + +  L ++ +D +E L                    Q +  +   + T
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELL--------------------QEETRQKLNVST 1336

Query: 928  KLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARG-KNANKN 986
            KLR+L+ +  +  D+    +  ++ LE  +     +L   ++K           +   K 
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETR--KSLEVVLYYKASQRKL-DGLAKEEEKKEEM 1043
              K    +  +   K  +       + R  + L+ ++    +QR+L   L K++ K +++
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456

Query: 1044 EEEKKQVKEE-AKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDAD 1102
              E+K +  + A E+   E  A   + +        EE  E KEE E+     + E +  
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 1103 SSLESPEENNPLRLSESKKSSPT 1125
             S +     N   L +SK++  T
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALET 1539



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 93/383 (24%), Positives = 175/383 (45%), Gaps = 59/383 (15%)

Query: 1    MQAMEGEVLLPALYEEEEEEEEEEE------EVEEEEEQVQKGGSVGSLSVNKHRGLSLT 54
            MQA++G+        +E+ EE+  +      E E E E  +K  ++ + +  K  G    
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG---- 1624

Query: 55   ETELEELRAQVLQLVAELEET----RELAGQHEDDSLELQGLL--EDERLASAQQAEVFT 108
              +L++L  Q    +   EE     R+L  Q +D   EL+      DE  A+A++ E   
Sbjct: 1625 --DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE--- 1679

Query: 109  KQIQQLQGELRSLREEISLLEHEKES---ELKEIEQELHLAQAEIQSLRQAAEDSATEHE 165
            K+ + L+ +L  L+E+++  E  ++    E +E+ +EL    A   S R A +D     E
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL----ASSLSGRNALQDEKRRLE 1735

Query: 166  SDIASLQEDLCRMQNELEDM-ERIRGDYEMEIASLRAEM---EMKSSEPSGSLGLSDYSG 221
            + IA L+E+L   Q  +E M +R+R       A+ +AE    E+ +   +     S    
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRK------ATQQAEQLSNELATERSTAQKNESARQQ 1789

Query: 222  LQEELQELRERYHFLNEEYRALQESN-SSLTGQLADLESERTQRATERWLQSQTLSMTSA 280
            L+ + +ELR + H +    ++  +S  ++L  ++A LE +  Q A E+  Q+ T S+   
Sbjct: 1790 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK--QAATKSLKQK 1847

Query: 281  ESQTSEMDFLEPDPEMQL-----------------LRQQLRDAEEQMHGMKNKCQELCCE 323
            + +  E+  L+ + E ++                 L++QL +AEE+   +    ++L  E
Sbjct: 1848 DKKLKEI-LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906

Query: 324  LEELQHHRQVSEEEQRRLQRELK 346
            L+E     +    E   L+ +L+
Sbjct: 1907 LDEATESNEAMGREVNALKSKLR 1929


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  143 bits (360), Expect = 1e-33
 Identities = 235/1113 (21%), Positives = 453/1113 (40%), Gaps = 169/1113 (15%)

Query: 68   LVAELEETRELAGQHEDDSLELQ----GLLEDERLASAQQAEVFTKQIQQLQGELRSLRE 123
            ++A LEE R+L  +  D  +  Q    G L  +  A  QQ     K +Q+       LR 
Sbjct: 767  VLAHLEEERDL--KITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRN 824

Query: 124  EISLLEHEKESELKEI---EQELHLAQAEIQSLRQ---AAEDSATEHESDIASLQEDLCR 177
                    K   L ++   E+E+   + E+  +R+   AAE+  TE E+    LQ  L  
Sbjct: 825  WQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMET----LQSQL-- 878

Query: 178  MQNELEDMERIRGDYEM--EIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHF 235
            M  +L+  E+++ + E+  E   LRA +  K  E            L+  ++E  ER   
Sbjct: 879  MAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEIC-----HDLEARVEEEEERCQH 933

Query: 236  LNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPE 295
            L  E + +Q++   L  QL + ES R +   E+      L     E    E    +   E
Sbjct: 934  LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993

Query: 296  MQLLRQQLRD-----AEEQ-----MHGMKNKCQELCCELEELQHHRQVSEEEQRRLQREL 345
             +LL  ++ +      EE+     +  +KNK + +  +LEE     +   +E  + +R+L
Sbjct: 994  KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053

Query: 346  KCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVM 405
            +    + L  Q +    Q  ELK +L    KK +  Q     + +   Q    L++++ +
Sbjct: 1054 EGDSTD-LSDQIAELQAQIAELKMQLA---KKEEELQAALARVEEEAAQKNMALKKIREL 1109

Query: 406  KSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVA 465
            +S + E Q + E             +    + K  ++++ L EEL+  + EL+   D+ A
Sbjct: 1110 ESQISELQEDLE-------------SERASRNKAEKQKRDLGEELEALKTELEDTLDSTA 1156

Query: 466  S--------------FKESNEKDTETH-AQLQEMKQLYQASKDELERQKHMYDQLEQDLL 510
            +               K++ E++ +TH AQ+QEM+Q +  + +EL  Q     +++ +L 
Sbjct: 1157 AQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLE 1216

Query: 511  LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED 570
                     KA   +  ++G+ AN+   LL    + + K K  + ++ +LQ++  E    
Sbjct: 1217 ---------KAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV 1267

Query: 571  QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKL-EDLCELQLLYQGMQE------ 623
            +  + ++  +LQ EL  +T      GLL +S    +KL +D   L+   Q  QE      
Sbjct: 1268 RTELADKVTKLQVELDNVT------GLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN 1321

Query: 624  EQK-------KLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDD--SKLAKSSKCNR 674
             QK       K ++++    +EQLE  EE +   E     +     D   K+  S  C  
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381

Query: 675  NKQS--KLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQV 732
              +   + L + ++ L   ++   A  + L++ + RL +E   L  DL          Q 
Sbjct: 1382 TAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH--------QR 1433

Query: 733  QSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDS 792
            QS     +LE   K +  ++   +     Y    D  E+  +   +   S    L+    
Sbjct: 1434 QSAC---NLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490

Query: 793  STSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDME----R 848
              +  E   K + T     ++ K   G +       K  +    +E   + E++E     
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQA 1550

Query: 849  FEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQ-KDLKEELDACEREFKECME 907
             E+  +++ + LQA++A ++   +   +  E+ +K L +Q ++++ EL+          E
Sbjct: 1551 TEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED---------E 1601

Query: 908  CLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQL 967
              ++ MA    K    +L+  L++L+    ++   +   +    +L+ Q++ C  EL   
Sbjct: 1602 RKQRSMAVAARK----KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT 1657

Query: 968  REKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQ 1027
            R  R  ++ +A+ +N  K  +  A  ++++                              
Sbjct: 1658 RASREEILAQAK-ENEKKLKSMEAEMIQLQ------------------------------ 1686

Query: 1028 RKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVA-EPADPEEAKSTEDQEENEEDKE 1086
               + LA  E  K + ++E+ ++ +E     G   +A E     EA+  + +EE EE++ 
Sbjct: 1687 ---EELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG 1743

Query: 1087 EEEKEEDSEEEEDDADSSLESPEENNPLRLSES 1119
              E   D  ++     ++L+  + N  L L  S
Sbjct: 1744 NTELINDRLKK-----ANLQIDQINTDLNLERS 1771



 Score =  135 bits (340), Expect = 2e-31
 Identities = 244/1197 (20%), Positives = 494/1197 (41%), Gaps = 202/1197 (16%)

Query: 9    LLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQV--- 65
            LL    +EEE   +EEE V+  E+Q+     +               TE+E L++Q+   
Sbjct: 837  LLQVSRQEEEMMAKEEELVKVREKQLAAENRL---------------TEMETLQSQLMAE 881

Query: 66   -LQLVAELEETRELAGQHED----------------DSLELQGLLEDERLASAQ-QAEVF 107
             LQL  +L+   EL  + E+                  LE +   E+ER    Q + +  
Sbjct: 882  KLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKM 941

Query: 108  TKQIQQLQGEL---RSLREEISLLEHEKESELKEIEQE---LHLAQAEIQSLRQAAEDSA 161
             + IQ+L+ +L    S R+++ L +   E++LK++E+E   L     ++   ++  ED  
Sbjct: 942  QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI 1001

Query: 162  TE---------------------HESDIASLQEDLCRMQNELEDMERIR----------- 189
             E                     HE+ I  L+E L R + + +++E+ R           
Sbjct: 1002 AEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061

Query: 190  ---GDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQ-----EELQELRERYHFLNEEYR 241
                + + +IA L+ ++  K  E   +L   +    Q     ++++EL  +   L E+  
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 1121

Query: 242  ALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQ 301
            + + S +    Q  DL  E     TE      TL  T+A+ +       E +   + L +
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTE---LEDTLDSTAAQQELRSKREQEVNILKKTLEE 1178

Query: 302  QLRDAEEQMHGMKNK----CQELCCELEELQHHRQVSEEEQRRLQRELKCAQNE--VLRF 355
            + +  E Q+  M+ K     +EL  +LE+ +  +   E+ ++ L+ E     NE  VL  
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238

Query: 356  QTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSE 415
                S  + ++++++L  LQ K++  +  + EL     +LQ EL     +   L ++ S+
Sbjct: 1239 GKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDN---VTGLLSQSDSK 1295

Query: 416  KELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQ---CHEAELQHLRDTVASFKESNE 472
               L +         + +  + +L + Q+ LQEE +       +L+ + D   SF+E  E
Sbjct: 1296 SSKLTK---------DFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE 1346

Query: 473  KDTET-----------HAQLQEMKQLYQASKDELERQKHMYDQLEQDLL-LCQLELKELK 520
            ++ E            HAQ+ +MK+  + S   LE  + +  +L++DL  L Q   +++ 
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA 1406

Query: 521  ASHPIPEDKGKCANKCDTLLSRLTELQE---KYKASQKEMGQLQMEQCELLEDQRRMQEE 577
            A   + + K +   + D LL  L   ++     +  QK+  QL  E+  +     +  EE
Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI---SAKYAEE 1463

Query: 578  QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLK 637
            + + + E         ++  L  ++ L   +E   EL+ L +  + E + L+ ++D V K
Sbjct: 1464 RDRAEAEARE-----KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGK 1518

Query: 638  EQLEIHEELRRFKESHFQEV---LENPDDSKLAKSSKCNRNKQSKLLME-QMQALQVMYD 693
               E+ E+ +R  E   +E+   LE  +D   A        + +KL +E  +QA++  ++
Sbjct: 1519 SVHEL-EKSKRALEQQVEEMKTQLEELEDELQA-------TEDAKLRLEVNLQAMKAQFE 1570

Query: 694  AG-QAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMV 752
               Q + E  ++++ +L+ + + ++A+L+   ++  +       ++M L           
Sbjct: 1571 RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL----------- 1619

Query: 753  PSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSI 812
               ++     D+   + +   K     Q   K  ++  D + ++ E         + +  
Sbjct: 1620 ---KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE------ILAQAKE 1670

Query: 813  TYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMV------VKVLIKLQAVQAM 866
              KK     +     Q+   ++   +  A+ E  E  +E+          L + + ++A 
Sbjct: 1671 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730

Query: 867  YQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFK-ECMECLEKPMAPQNDKNEIKEL 925
                +EE  + Q   E +  + K    ++D    +   E     +   A Q  + + KEL
Sbjct: 1731 IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKEL 1790

Query: 926  QTKLRELQ----LQYQASMDE-QGRLLVVQEQLEGQL---QCCQEELRQLREKRPSVVKE 977
            + KL+E++     +Y+AS+   + ++  ++EQL+ +    Q   +++R+  +K   V+ +
Sbjct: 1791 KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ 1850

Query: 978  ARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLD-GLAKE 1036
               +  N    K+       ++ +      E++ E +++        AS+RKL   L   
Sbjct: 1851 VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA-------NASRRKLQRELEDA 1903

Query: 1037 EEKKEEMEEEKKQVKEE--------------AKEQCG---DELVAEPADPEEAKSTE 1076
             E  + M  E   +K +              A++  G   DE V   AD  EAK  E
Sbjct: 1904 TETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPAE 1960



 Score =  117 bits (292), Expect = 8e-26
 Identities = 187/972 (19%), Positives = 387/972 (39%), Gaps = 160/972 (16%)

Query: 3    AMEGEVLLPALYEEEEEEEEE----------EEEVEEEEEQVQKGGSVGSLSVNKHRGLS 52
            A + E L  AL   EEE  ++          E ++ E +E ++   +  + +  + R L 
Sbjct: 1079 AKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLG 1138

Query: 53   LTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQ 112
                ELE L+ ++   +      +EL  + E +   L+  LE+E      Q +   ++  
Sbjct: 1139 ---EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195

Query: 113  QLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQ 172
            Q   EL    E+   ++   E   + +E E      E++ L Q   DS  + +   A LQ
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255

Query: 173  EDLCRMQNELEDMERIRGDYEMEIASLRAEME-----MKSSEPSGSLGLSDYSGLQEELQ 227
            E    +Q +  + ER+R +   ++  L+ E++     +  S+   S    D+S L+ +LQ
Sbjct: 1256 E----LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311

Query: 228  ELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEM 287
            + +E           LQE N                         Q LS+++   Q  + 
Sbjct: 1312 DTQE----------LLQEEN------------------------RQKLSLSTKLKQVED- 1336

Query: 288  DFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKC 347
                   E    R+QL + EE  H ++ +   L         H QV+ + +++++  + C
Sbjct: 1337 -------EKNSFREQLEEEEEAKHNLEKQIATL---------HAQVA-DMKKKMEDSVGC 1379

Query: 348  AQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKS 407
                    +T+  V    +L+  L  L ++++      ++L K + +LQ EL  L     
Sbjct: 1380 -------LETAEEV--KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL----- 1425

Query: 408  TLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASF 467
             LV+   +++  C L+K   +   +  E++ +     +  EE    EAE +       S 
Sbjct: 1426 -LVDLDHQRQSACNLEKKQKKFDQLLAEEKTI---SAKYAEERDRAEAEAREKETKALSL 1481

Query: 468  KESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPE 527
              + E+  E  A+L+ + + ++   ++L   K                    K+ H + +
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVG----------------KSVHELEK 1525

Query: 528  DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQME-QCELLEDQRRMQEEQGQLQEELH 586
             K     + + + ++L EL+++ +A++    +L++  Q    + +R +Q    Q +E+  
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK-- 1583

Query: 587  RLTLPLPKSGLLLKSQELLTKLEDLCELQLL----YQGMQEEQKKLIQNQDCVLKEQLEI 642
                   K  L+ + +E+  +LED  + + +     + ++ + K L  + D   K + E 
Sbjct: 1584 -------KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636

Query: 643  HEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQA----LQVMYDAGQAK 698
             ++LR+  ++  ++ +   DD++ ++     + K+++  ++ M+A    LQ    A +  
Sbjct: 1637 IKQLRKL-QAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERA 1695

Query: 699  QELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENC 758
            +   QQE+  L +E         L LEE + L+ +   ++  LE   +  G+    N+  
Sbjct: 1696 KRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELE---EEQGNTELINDRL 1752

Query: 759  RKT------YDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSI 812
            +K        +T ++   S+ +   + +   +   K         E   KS         
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS--------- 1803

Query: 813  TYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQE 872
             YK S  +  +     +  + + T E  A  + + R E+ +  VL+++          + 
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDD-------ERR 1856

Query: 873  EHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQND--------KNEIKE 924
               Q ++Q +K   + K LK +L+  E E +       K      D          E+  
Sbjct: 1857 NAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916

Query: 925  LQTKLRELQLQY 936
            L+ KLR   L +
Sbjct: 1917 LKNKLRRGDLPF 1928



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 83/359 (23%), Positives = 162/359 (45%), Gaps = 28/359 (7%)

Query: 1    MQAMEGEVLLPALYEEEEEEEEEEE---EVEEEEEQVQKGGSVGSLSVNKHRGLSLTETE 57
            +QAM+ +        +E+ EE++++   +V E E +++      S++V   + L   E +
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL---EMD 1618

Query: 58   LEELRAQVLQLVAELEET----RELAGQHEDDSLELQGLL--EDERLASAQQAEVFTKQI 111
            L++L A +       +E     R+L  Q +D   EL       +E LA A++ E   K++
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENE---KKL 1675

Query: 112  QQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASL 171
            + ++ E+  L+EE++  E  K    +E   EL    A        A +     E+ IA L
Sbjct: 1676 KSMEAEMIQLQEELAAAERAKRQAQQE-RDELADEIANSSGKGALALEEKRRLEARIAQL 1734

Query: 172  QEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQ-EELQ-EL 229
            +E+L   Q   E +        ++I  +  ++ ++ S    +         Q +EL+ +L
Sbjct: 1735 EEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKL 1794

Query: 230  RERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDF 289
            +E    +  +Y+A   S ++L  ++A LE +      ER  Q+    +   E +  ++  
Sbjct: 1795 QEMEGTVKSKYKA---SITALEAKIAQLEEQLDNETKER--QAACKQVRRTEKKLKDV-L 1848

Query: 290  LEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA 348
            L+ D E    R+     ++Q      + ++L  +LEE +   Q +   +R+LQREL+ A
Sbjct: 1849 LQVDDE----RRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  142 bits (358), Expect = 2e-33
 Identities = 249/1158 (21%), Positives = 489/1158 (42%), Gaps = 121/1158 (10%)

Query: 13   LYEEEEEEEEEEEEVEEEE-EQVQKGGSVGSLSVNKHRGLSLTETELEE----------- 60
            L E+E++ ++ +E ++ ++ E ++   S    S+   + +  T  + E            
Sbjct: 584  LREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAF 643

Query: 61   LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS 120
            LR++ L+L  +++E      Q E+D    Q  LE ++           K++Q    E+  
Sbjct: 644  LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD----LEKELQSAFNEITK 699

Query: 121  LREEIS-------LLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQE 173
            L   I        L   E E ++ ++++EL+    E ++LR+          S++ SL  
Sbjct: 700  LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL-----SELKSLPS 754

Query: 174  DLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLG------------LSDYSG 221
            ++ R++ E++D          E   L +E+  K S   G L              S+Y  
Sbjct: 755  EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS 814

Query: 222  LQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAE 281
              +E Q  +  +    ++Y+ + E N  +  ++ +L  E  +  +        LS  + E
Sbjct: 815  TDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE 874

Query: 282  SQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRL 341
             Q    +  E   EM+ L++QL + +  +  ++   +E     E+LQ     + EE + L
Sbjct: 875  LQEKTREVQERLNEMEQLKEQLENRDSTLQTVE---REKTLITEKLQQ----TLEEVKTL 927

Query: 342  QRELKCAQNEVLRFQTSHSVTQNEELKSRL-CTLQKKYDTSQDEQNELLKMQLQLQTELR 400
             +E    ++++ + Q S  + + ++LKS +  T+    DT +  +N L  ++ Q Q  + 
Sbjct: 928  TQE----KDDLKQLQESLQI-ERDQLKSDIHDTVNMNIDTQEQLRNALESLK-QHQETIN 981

Query: 401  QLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQ--QQLQEELQCHEAELQ 458
             LK   S  V      E      K   Q + V  +K++ LE +  Q L  +++ +E  ++
Sbjct: 982  TLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEI-IE 1040

Query: 459  HLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLE--QDLLLCQLEL 516
              R   +  +E NE      + + E +QL    K+ +E      ++L    D L  Q E+
Sbjct: 1041 QQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI 1100

Query: 517  KELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQE 576
               + +H I ++ G+ +  CD    RL E++EK K   +   QLQ +Q +LL  Q  M E
Sbjct: 1101 VAQEKNHAIKKE-GELSRTCD----RLAEVEEKLKEKSQ---QLQEKQQQLLNVQEEMSE 1152

Query: 577  EQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVL 636
             Q ++  E+  L   L    L L+  E   +LE   +L   Y     E+ K I  +  VL
Sbjct: 1153 MQKKI-NEIENLKNELKNKELTLEHME-TERLELAQKLNENY-----EEVKSITKERKVL 1205

Query: 637  KEQLEIHEELRRFKESHFQEV----LENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMY 692
            KE  +  E  R     + +E+    L+  ++ K+A             L E  + +  + 
Sbjct: 1206 KELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIH----------LKEHQETIDELR 1255

Query: 693  DAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMV 752
             +   K   +   Q  L +   +LQ ++ +  EE +LL    P++K   E+        +
Sbjct: 1256 RSVSEKTAQIINTQD-LEKSHTKLQEEIPVLHEEQELL----PNVKEVSETQETMNELEL 1310

Query: 753  PSNENCRKTYDTTVD---DNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYG-KSYCTTS 808
             + ++  K   T      +     + +  +Q   KS  K  D+  +  EA   K      
Sbjct: 1311 LTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE 1370

Query: 809  NSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERF---EEMVVKVLIKLQAVQA 865
            +   T  K   S S  +  Q   +    +E      +ME+F   +  ++++ I++  +  
Sbjct: 1371 HIRETLAKIQESQSKQE--QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSK 1428

Query: 866  MYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECM-ECLEKPMAPQNDKNEIKE 924
              Q S +E   + ++ + L   Q+ L+ E D  +   KE + + LE     +     +KE
Sbjct: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488

Query: 925  LQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNAN 984
             +  + EL++      +++  +  +Q+QLE      Q +++++ EK     +E       
Sbjct: 1489 QEETINELRVNLS---EKETEISTIQKQLEAINDKLQNKIQEIYEK-----EEQFNIKQI 1540

Query: 985  KNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEME 1044
              + +  N +K  K  +   D++   +E+ K LE+    + SQ ++  + KE+E+ + ++
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSALQSIES-KMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599

Query: 1045 E----EKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDD 1100
            E    E+ Q+KE  KE       ++  + +  K T   E  E+  E E  +E  E ++  
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQK-- 1657

Query: 1101 ADSSLESPEENNPLRLSE 1118
               +LE+ E  N +RL++
Sbjct: 1658 --LNLENIETEN-IRLTQ 1672



 Score =  122 bits (307), Expect = 2e-27
 Identities = 252/1186 (21%), Positives = 488/1186 (41%), Gaps = 146/1186 (12%)

Query: 18   EEEEEEEEEVEEEEEQVQK-GGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETR 76
            EE E   +E+    ++ QK   S+G+L       LS    EL+E   +V + + E+E+ +
Sbjct: 838  EENERMNQEIVNLSKEAQKFDSSLGALKTE----LSYKTQELQEKTREVQERLNEMEQLK 893

Query: 77   ELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESEL 136
            E   ++ D +L+    +E E+    ++ +   ++++ L  E   L++    L+ E++   
Sbjct: 894  EQL-ENRDSTLQT---VEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLK 949

Query: 137  KEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQ----EDLCRMQNELEDMERIRGDY 192
             +I   +++     + LR A E S  +H+  I +L+    E++ R  +  E+    + ++
Sbjct: 950  SDIHDTVNMNIDTQEQLRNALE-SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEF 1008

Query: 193  EMEIASL--RAEMEMKSSEPSGSLGLSD----------YSGLQE--ELQELRERYHFLNE 238
            + ++  +  + ++E K+++   +  + D          +S +QE  ELQ++ E      E
Sbjct: 1009 QQKMVGIDKKQDLEAKNTQTL-TADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067

Query: 239  EYRALQESNSSLT-----------GQLADLESERTQRATERWLQSQTLSMTSAESQTSEM 287
            + +   + N  +T            +L   +    Q       +   LS T       E 
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127

Query: 288  DFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEE-EQRRLQRELK 346
               E   ++Q  +QQL + +E+M  M+ K  E+     EL++     E  E  RL+   K
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187

Query: 347  CAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQN----ELLKMQLQLQTELR-- 400
              +N    ++   S+T+  ++   L  LQK ++T +D       E+    LQ + EL+  
Sbjct: 1188 LNEN----YEEVKSITKERKV---LKELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240

Query: 401  --QLKVMKSTLVE---NQSEKEL-LCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHE 454
               LK  + T+ E   + SEK   +   Q L   H  +  E   L E Q+ L    +  E
Sbjct: 1241 HIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300

Query: 455  AELQHLRDTVASFKESNEKDTETHAQLQ----EMKQLYQASKDELERQKHMYDQLEQDLL 510
             + + + +     ++S  KD+ T A+++     + + +Q S++E++      D L+   +
Sbjct: 1301 TQ-ETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKT--I 1357

Query: 511  LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQK---EMGQLQMEQCEL 567
               LE+K  +    I E   K   +  +   +   ++EK   + K   EM Q + +   L
Sbjct: 1358 KEALEVKHDQLKEHIRETLAKI-QESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSAL 1416

Query: 568  LEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCE---LQLLYQGMQEE 624
            L  +  M     +LQE    +     +   L + QE+L    D  +    +++ + ++ E
Sbjct: 1417 LRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETE 1476

Query: 625  QKKLIQNQDCVLKEQLEIHEELR------RFKESHFQEVLENPDDSKLAKSSKCNRN--- 675
            ++  + +  C LKEQ E   ELR        + S  Q+ LE  +D    K  +       
Sbjct: 1477 EELKVAH--CCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ 1534

Query: 676  ---KQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQV 732
               KQ   + E++  L+   +  +AK   LQ  + ++LE   RLQ       EE+Q++  
Sbjct: 1535 FNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQ----EEIQIMIK 1590

Query: 733  QSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDS 792
            +   +K   E+        +  ++    T +      ES  K Y         FLK    
Sbjct: 1591 EKEEMKRVQEAL------QIERDQLKENTKEIVAKMKESQEKEY--------QFLKM--- 1633

Query: 793  STSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDM-ERFEE 851
             T+ +E   K         I + K    T      QK  + +   E     + + E  EE
Sbjct: 1634 -TAVNETQEKM------CEIEHLKEQFET------QKLNLENIETENIRLTQILHENLEE 1680

Query: 852  M--VVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECL 909
            M  V K    L++V+   ++   E  QL+E + + + +  + +EEL       KE  E +
Sbjct: 1681 MRSVTKERDDLRSVEETLKV---ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETI 1737

Query: 910  EKPMAPQNDK-NEIKELQTKLRELQLQYQAS-MDEQGRLLVVQEQLEGQLQCCQEELRQL 967
            +K     ++K NEI  +Q  L       +A  +  Q  L +    L+ Q    QE + +L
Sbjct: 1738 DKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQ----QETIDKL 1793

Query: 968  R-------EKRPSVVKEARGKNAN---KNMNKNANGVKMKKVTKPCSDTSE--SDLETRK 1015
            R       +K  ++ K+    NA    K     AN  ++  + K  ++T +  S++E  K
Sbjct: 1794 RGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK 1853

Query: 1016 SLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKST 1075
                      S+ +++ L   ++  E +EE K  +KE    +  +E +    D  +    
Sbjct: 1854 KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913

Query: 1076 EDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
            E +  + E ++E +      +E  +    L        +++S+ +K
Sbjct: 1914 ETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959



 Score =  109 bits (273), Expect = 1e-23
 Identities = 213/1170 (18%), Positives = 477/1170 (40%), Gaps = 147/1170 (12%)

Query: 13   LYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAEL 72
            L E+ +E +EE + + +E + ++               L +   +L+E   + L  + E 
Sbjct: 1333 LNEKFQESQEEIKSLTKERDNLK----------TIKEALEVKHDQLKEHIRETLAKIQES 1382

Query: 73   EETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQL--QGELRSLREEISLLEH 130
            +  +E +   ++   E   ++ +      + + +   +I+ L     L+   +E+  +  
Sbjct: 1383 QSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK 1442

Query: 131  EKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIR- 189
            EK+ +L+ +++ L   Q+E   L++  ++   +H      L+   C ++ + E +  +R 
Sbjct: 1443 EKD-DLQRLQEVL---QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRV 1498

Query: 190  --GDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESN 247
               + E EI++++ ++E  + +            LQ ++QE+ E+    N   + + E  
Sbjct: 1499 NLSEKETEISTIQKQLEAINDK------------LQNKIQEIYEKEEQFN--IKQISEVQ 1544

Query: 248  SSLTGQLADLESERTQRATERWLQSQTLSMTSA--ESQTSEMDFLEPDPEMQLLRQQLRD 305
              +       E  + + +  + ++S+ L +T+   ESQ      ++   EM+ +++ L+ 
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604

Query: 306  AEEQMHGMKNKCQELCCELEELQHHRQ-------VSEEEQRRLQRELKCAQNEVLRFQTS 358
              +Q+   K   +E+  +++E Q           V+E +++  + E    Q E  +    
Sbjct: 1605 ERDQL---KENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE 1661

Query: 359  HSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKEL 418
            +  T+N  L   L    ++  +   E+++L  ++  L+ E  QLK      +    EK+ 
Sbjct: 1662 NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQE 1721

Query: 419  LCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTV-ASFKESNEKDTET 477
              ++  +HL+    T +K + +  ++    E+   + +L+H  D + A   +  E+    
Sbjct: 1722 ELKIVHMHLKEHQETIDKLRGIVSEK--TNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779

Query: 478  HAQLQEMKQ----LYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCA 533
            H  L+E ++    L     ++ ++  +M   LE      Q +++ELKA+        K  
Sbjct: 1780 HMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV 1839

Query: 534  NKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRL----- 588
            N+    +S + +L+++ K     + +L++E   L +      EE   + +E   L     
Sbjct: 1840 NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEE 1899

Query: 589  TLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRR 648
            TL L +  L    QE  TK  DL E+Q   Q ++  +    ++++ V K + +I E  + 
Sbjct: 1900 TLKLERDQLKESLQE--TKARDL-EIQ---QELKTARMLSKEHKETVDKLREKISE--KT 1951

Query: 649  FKESHFQEVLENPDDSKLAKSSKCNRNKQSKLL------------MEQMQALQVMYDAGQ 696
             + S  Q+ L+   D +L K  +  + K+ +LL            + +M+ L+  ++A  
Sbjct: 1952 IQISDIQKDLDKSKD-ELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQN 2010

Query: 697  AKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVP--- 753
               + ++ +  +L ++      ++++  +E   L+    S+KM  + +  +   M+    
Sbjct: 2011 LSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDR 2070

Query: 754  SNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGK----------- 802
             N   +       D  +   +S     +  K  LK Y       E   +           
Sbjct: 2071 QNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEF 2130

Query: 803  ----SYCTTSNSSITY---KKSYGSTSSSDTCQKSF----------VSSCTDEEPAEPED 845
                S    +N S+ Y   K      +++  C   F          +S  T  +  + E 
Sbjct: 2131 QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHES 2190

Query: 846  MERFE-------EMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDAC 898
            + +FE       E   ++LIK+Q +Q    +   E   L+      L  ++ LK   D  
Sbjct: 2191 INKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK---DFS 2247

Query: 899  EREFKECMECLEKPMAPQNDKNEIKE--LQTKLRELQLQYQASMDEQGRLLVVQEQLEGQ 956
            E EF       ++ ++ + +  +  E  L T+  +++        E  R+  V      +
Sbjct: 2248 ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF-DIEKLKNGIQKENDRICQVNNFFNNR 2306

Query: 957  LQCCQEELRQLREKRPSVVKEARG-----KNANKNMNKN--------ANGVKMKKVTKPC 1003
            +     E  +  E+  ++ KE        K  N+ + KN        A+G ++   T+  
Sbjct: 2307 IIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN 2366

Query: 1004 SDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELV 1063
             +   +   T+ + E +       R+L+  +  E K+  M +E K +K + + +  ++++
Sbjct: 2367 KNPHVTSRATQLTTEKI-------RELEN-SLHEAKESAMHKESKIIKMQKELEVTNDII 2418

Query: 1064 AEPADPEEAKSTEDQEENEEDKEEEEKEED 1093
            A+     +AK  E  +  E+ KE  +  +D
Sbjct: 2419 AK----LQAKVHESNKCLEKTKETIQVLQD 2444



 Score =  100 bits (250), Expect = 6e-21
 Identities = 230/1182 (19%), Positives = 475/1182 (40%), Gaps = 124/1182 (10%)

Query: 17   EEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELE--- 73
            E+EE+   +++ E +E+V +          K   L   E+++ EL  ++ +   E++   
Sbjct: 1530 EKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI 1589

Query: 74   -ETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQ-GELRSLREEISLLEHE 131
             E  E+    E   +E   L E+ +   A+  E   K+ Q L+   +   +E++  +EH 
Sbjct: 1590 KEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHL 1649

Query: 132  KES------ELKEIEQE-LHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELED 184
            KE        L+ IE E + L Q   ++L +    S T+   D+ S++E L   +++L++
Sbjct: 1650 KEQFETQKLNLENIETENIRLTQILHENLEEMR--SVTKERDDLRSVEETLKVERDQLKE 1707

Query: 185  --MERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELR----ERYHFLNE 238
               E I  D E +       M +K                QE + +LR    E+ + ++ 
Sbjct: 1708 NLRETITRDLEKQEELKIVHMHLKEH--------------QETIDKLRGIVSEKTNEISN 1753

Query: 239  EYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQL 298
              + L+ SN +L  Q  DL+ +   R     L+ Q  ++       SE        +   
Sbjct: 1754 MQKDLEHSNDALKAQ--DLKIQEELRIAHMHLKEQQETIDKLRGIVSE--------KTDK 1803

Query: 299  LRQQLRDAEEQMHGMKNKCQELCCELEEL--------QHHRQVSEEEQRRLQ---RELKC 347
            L    +D E     ++ K QEL     +L        +  ++VSE EQ + Q   + L  
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTL 1863

Query: 348  AQNEVLRFQTSHSVTQN-EELKSRLC----------TLQKKYDTSQDEQNELLKMQLQLQ 396
            ++ E+     +  + +N EE+KS +           TL+ + D  ++   E     L++Q
Sbjct: 1864 SKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQ 1923

Query: 397  TELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAE 456
             EL+  +++       ++  +L  ++ +  +Q  ++  + +K  +  Q+  +ELQ  E +
Sbjct: 1924 QELKTARMLSKE--HKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQ 1981

Query: 457  LQHLRDTV-ASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQL- 514
            L  +++ V  S K+ NE +        +   +     D  +  K +++ LE+  ++ +  
Sbjct: 1982 LLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKER 2041

Query: 515  -ELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKA----SQKEMGQLQMEQCELLE 569
             EL+ +K S  +  D+     +      R     +  K      Q+ + +   E+C  ++
Sbjct: 2042 DELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIK 2101

Query: 570  DQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLI 629
            +  +   E     E L+RL+L L K     K   +  K      L L Y   +  +K   
Sbjct: 2102 ELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVK----ANLSLPYLQTKHIEKLFT 2157

Query: 630  QNQDCVLKEQLEIHEELRRFKE--SHFQEVLENPDDS--KLAKSSKCNRNKQSKLLMEQM 685
             NQ C     +E H  +++ K   S+  ++ E   +S  K          KQ +LL++ +
Sbjct: 2158 ANQRC----SMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIK-I 2212

Query: 686  QALQVMYD--AGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMS--L 741
            Q LQ   D  + + +   L Q     +EE  +  ++ +    + +  QV S   +M+  L
Sbjct: 2213 QHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFL 2272

Query: 742  ESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYG 801
            E +  +   +       +K  D     N  +     +    S  F    + S + S+ + 
Sbjct: 2273 EEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEF---EERSATISKEWE 2329

Query: 802  KSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQ 861
            +   +    +    K+Y +  +S         + T ++   P    R  ++  + + +L+
Sbjct: 2330 QDLKSLKEKNEKLFKNYQTLKTS--LASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELE 2387

Query: 862  -AVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQND-- 918
             ++    + +  + S++ + M+K L    D+  +L A   E  +C+E  ++ +    D  
Sbjct: 2388 NSLHEAKESAMHKESKIIK-MQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKV 2446

Query: 919  -------KNEIKELQTKLRELQLQYQASMDE-QGRLLVVQEQLEGQ---LQCCQEELRQL 967
                   K EI++L+ KL ++ L+   +  E +  +   +  +E Q   ++  +E LR+ 
Sbjct: 2447 ALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRS 2506

Query: 968  REKR-PSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKAS 1026
            ++ +  SV+ E      +        G  + + TK     SE     R   E+    + +
Sbjct: 2507 QQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSE---HIRLEKEISKLKQQN 2563

Query: 1027 QRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKE 1086
            ++ +    +     + +  E K  KE   ++   + V     P+  K T    + ++   
Sbjct: 2564 EQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITP 2623

Query: 1087 EEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNP 1128
             + KE + ++         ESP+           KS P+P+P
Sbjct: 2624 SQCKERNLQDPVPK-----ESPKS---CFFDSRSKSLPSPHP 2657



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 238/1216 (19%), Positives = 482/1216 (39%), Gaps = 191/1216 (15%)

Query: 51   LSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQ 110
            +S  E  L+  R +++ L  +LEE          +  +L  LLE++ L    Q E     
Sbjct: 338  VSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNE----- 392

Query: 111  IQQLQGELRSLREEISL-LEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIA 169
              +++   R L    SL L+ E +++ K   + +     +I  ++ +         ++I 
Sbjct: 393  --KIENLTRMLVTSSSLTLQQELKAKRK---RRVTWCLGKINKMKNSNYADQFNIPTNIT 447

Query: 170  SLQEDLC-RMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQE 228
            +    L   +  E+++      D         +E+E   +       L +   ++ EL  
Sbjct: 448  TKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATK-----LLNQENIESELNS 502

Query: 229  LRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMD 288
            LR  Y  L  +Y  L+     +  +L +        A ER              +  EM 
Sbjct: 503  LRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALER-----------KTKKDQEMQ 551

Query: 289  FLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA 348
             +    E+  L+  ++ AE     ++N   EL  ++E L+      E++ ++LQ  +   
Sbjct: 552  LIH---EISNLKNLVKHAEVYNQDLEN---ELSSKVELLRE----KEDQIKKLQEYIDSQ 601

Query: 349  QNEVLRFQTSHSV-------------------------------TQNEELKSRLCTLQKK 377
            + E ++   S+S+                               ++N ELK ++  L   
Sbjct: 602  KLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATT 661

Query: 378  YDTSQDE----QNEL---LKMQLQLQTELRQL--KVMKST-LVENQSEKELLCRLQK--- 424
            Y   +++    Q++L    KMQ+ L+ EL+    ++ K T L++ +  K+LLC L+    
Sbjct: 662  YKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK 721

Query: 425  -LHLQHQ-NVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKE-----SNEKD--- 474
               LQ + N   E+ + L  +  L  EL+   +E++ LR  +    E     ++EKD   
Sbjct: 722  ITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLF 781

Query: 475  ---TETHAQLQEMKQLYQASKDELERQKHMYDQLEQDL-----------LLCQLELKELK 520
                   +++Q + +    +KD+L   +  Y   +Q+               ++ L+E +
Sbjct: 782  SEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENE 841

Query: 521  ASHPIPEDKGKCANKCDTLLSRL-TELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQG 579
              +    +  K A K D+ L  L TEL  K +  Q++  ++Q    E+ + + +++    
Sbjct: 842  RMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDS 901

Query: 580  QLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQ 639
             LQ      TL   K    L+  + LT+ +D  +L+ L + +Q E+ +L  +    +   
Sbjct: 902  TLQTVEREKTLITEKLQQTLEEVKTLTQEKD--DLKQLQESLQIERDQLKSDIHDTVNMN 959

Query: 640  LEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRN--------------KQSKLLMEQM 685
            ++  E+LR   ES  ++  E  +  K   S + +RN              +Q  + +++ 
Sbjct: 960  IDTQEQLRNALES-LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK 1018

Query: 686  QALQV---------------------MYDAGQAKQELLQQEQGRLLEERKRLQADL---- 720
            Q L+                      ++   Q K E LQQ    ++ E+++L+ DL    
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE-LQQMLESVIAEKEQLKTDLKENI 1077

Query: 721  QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ 780
            ++ +E  + L++    +K   E   +     +       +T D   +  E   +     Q
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137

Query: 781  TSSKSFLKSYDSSTSASEAYGKSYCTTS---NSSITYKKSYGSTSSSDTCQK-----SFV 832
               +  L   +  +   +   +     +   N  +T +  +  T   +  QK       V
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE--HMETERLELAQKLNENYEEV 1195

Query: 833  SSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEE----HSQLQEQMEKLLAKQ 888
             S T E     E  + FE     +   ++ ++A    ++EE    H  L+E  E +   +
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255

Query: 889  KDLKE---------ELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQAS 939
            + + E         +L+    + +E +  L +      +  E+ E Q  + EL+L  + S
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQS 1315

Query: 940  MDEQ----GRLLVVQEQLEGQLQCCQEELRQLREKRPSV--VKEA---RGKNANKNMNKN 990
              +      R+ + + +L  + Q  QEE++ L ++R ++  +KEA   +     +++ + 
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375

Query: 991  ANGVKMKKVTKPCS-DTSESDLETRKSLEVVLYYKASQRKLDGLAKEE-EKKEEMEEEKK 1048
               ++  +  +  S +  E D ET K +  +  +K     L  +  E     + ++E   
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435

Query: 1049 QVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESP 1108
            ++K  AKE+  D+L       +E   +E  +  E  KE   K  ++EEE   A   L+  
Sbjct: 1436 EMKSVAKEK--DDL----QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ 1489

Query: 1109 EEN-NPLRLSESKKSS 1123
            EE  N LR++ S+K +
Sbjct: 1490 EETINELRVNLSEKET 1505



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 153/840 (18%), Positives = 323/840 (38%), Gaps = 142/840 (16%)

Query: 353  LRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVEN 412
            L+F ++    +N    + + T +      + E  +L K   ++  E R   + K  L + 
Sbjct: 320  LQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQL 379

Query: 413  QSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEE----------------------- 449
              EK+LL ++Q   +++          L  QQ+L+ +                       
Sbjct: 380  LEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQ 439

Query: 450  --------LQCHEAELQHLR---DTVASFKE--SNEKDTETHAQLQEMKQLYQASKDELE 496
                     + H+  +  LR   ++V S  +  SN  DT +  +     +L      E E
Sbjct: 440  FNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESE 499

Query: 497  RQKHM---------YDQLEQDLLLCQLELK-------------------ELKASHPIPED 528
                          Y+QL  +    +L+LK                   E++  H I   
Sbjct: 500  LNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNL 559

Query: 529  KG----------KCANKCDTLLSRLTELQEKYKASQKEMGQLQME--------QCELLED 570
            K              N+  + +  L E +++ K  Q+ +   ++E          E +ED
Sbjct: 560  KNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIED 619

Query: 571  QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ 630
             ++M+    Q   +   + L   +    L+S+ L  K E + EL   Y+ M+ + +    
Sbjct: 620  PKQMK----QTLFDAETVALDAKRESAFLRSENLELK-EKMKELATTYKQMENDIQLYQS 674

Query: 631  NQDCVLKEQLEIHEELRRFKESHFQEV--LENPDDSKLAKSSKCNRNKQSKLLMEQMQAL 688
              +   K Q+++ +EL    +S F E+  L +  D K+ K   CN   + K+   Q +  
Sbjct: 675  QLEAKKKMQVDLEKEL----QSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELN 730

Query: 689  QVMYDAGQAKQE-LLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKS 747
            + + +    ++E +L  E   L  E +RL+ ++Q   EE+ ++  +   +   +      
Sbjct: 731  KEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESR 790

Query: 748  YGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTT 807
               ++      +    TT  + +S  + + + +T    F + Y      +E   +     
Sbjct: 791  VQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNL 850

Query: 808  SNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMY 867
            S  +  +  S G+  +  + +   +   T E      +ME+ +E       +L+   +  
Sbjct: 851  SKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE-------QLENRDSTL 903

Query: 868  QISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQT 927
            Q  + E + + E++++ L + K L +E                        K+++K+LQ 
Sbjct: 904  QTVEREKTLITEKLQQTLEEVKTLTQE------------------------KDDLKQLQE 939

Query: 928  KLRELQLQYQASMDEQGRLLV-VQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
             L+  + Q ++ + +   + +  QEQL   L+  ++    +   +  + +E    + N +
Sbjct: 940  SLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEV---SRNLH 996

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYK-----ASQRKLDGLAKEEEKKE 1041
            M +N    K +   K      + DLE + +  +    K       QRK+  L +E+ + +
Sbjct: 997  MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056

Query: 1042 EMEE----EKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEE 1097
            +M E    EK+Q+K + KE    E+  E  + EE +   D+ + +++   +EK    ++E
Sbjct: 1057 QMLESVIAEKEQLKTDLKENI--EMTIE--NQEELRLLGDELKKQQEIVAQEKNHAIKKE 1112


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  140 bits (352), Expect = 9e-33
 Identities = 241/1121 (21%), Positives = 466/1121 (41%), Gaps = 148/1121 (13%)

Query: 55   ETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQL 114
            E E + LR ++ +L  E +    LAGQ  D   E+  L ++  L    + E+  +Q++ L
Sbjct: 427  EEEGKALRQRLQKLTGERDT---LAGQTVDLQGEVDSLSKERELLQKAREEL-RQQLEVL 482

Query: 115  QGE---LRSLREEISLLEHEKESELKEIEQELHLAQAE---IQSLRQAAEDSATEHESDI 168
            + E   LR +  E+ L     + + +E ++ELHLA  E   +Q +    E   +E  S++
Sbjct: 483  EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542

Query: 169  ASLQEDL--CRMQNELEDMERIRGDYEMEIASLRAEM---EMKSSEPSGSLGLSDYSGLQ 223
             +L+E L    ++ EL   E+     E+  A  RAE    E+ SSE +    ++D     
Sbjct: 543  ITLREALESSHLEGELLRQEQT----EVTAALARAEQSIAELSSSENTLKTEVADLRAAA 598

Query: 224  EELQELRERYHF----LNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTS 279
             +L  L E        LN++   L+E N S+  ++   E  R             L +  
Sbjct: 599  VKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQAR-----------NALQVDL 647

Query: 280  AESQTSEMDFLEPDPEMQLLRQQLRDA----EEQMHGMKNKCQELCCELEELQHHRQVSE 335
            AE++       E +  ++   Q+  +A    +  +  ++ + +E+  +L E +H ++ + 
Sbjct: 648  AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAAT 707

Query: 336  EEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQL 395
             +  +L +E K  Q EVL    + +V + E L      L+ +    + ++ +L +   QL
Sbjct: 708  TQLEQLHQEAK-RQEEVL----ARAVQEKEALVREKAALEVRLQAVERDRQDLAE---QL 759

Query: 396  QTELRQLKVMKSTLVENQSEKELL-CRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHE 454
            Q      ++++S+L E Q +  ++     +L +Q Q VT  KE +    + L+ EL    
Sbjct: 760  QGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTER 819

Query: 455  AELQHLRDTVASFKESNEKDTETHAQLQ------EMKQLYQASKDE-------------- 494
            ++ +  RD  A      E++ +T  + Q      E+ QL +  + E              
Sbjct: 820  SQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALES 879

Query: 495  LERQKHMYD------QLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQE 548
            LER+K   +      Q E + +  Q E +  +A   + + + +   +  +LL  L + Q+
Sbjct: 880  LEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQK 939

Query: 549  KYKASQKEMGQLQME---------------QCELLEDQRRMQEEQGQLQEELHRLTLPLP 593
            +   + +++ +L+ +               Q +L E QR ++E   Q +++L    L   
Sbjct: 940  ELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDL--AALQEE 997

Query: 594  KSGLLLKSQELLTKLEDLCELQLLYQG------MQEEQKKLIQNQDCVLKEQLEIHEELR 647
             S LL    +L  ++EDL + QL+ Q        QE Q+KL + Q     E   I +EL 
Sbjct: 998  SSSLLQDKMDLQKQVEDL-KSQLVAQDDSQRLVEQEVQEKLRETQ-----EYNRIQKELE 1051

Query: 648  RFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQG 707
            R K S    ++E      + + +   R ++   L + MQ  Q       A+ ELL+QE  
Sbjct: 1052 REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVK 1111

Query: 708  RLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVD 767
               +E   L  + QL LEE++   +    ++ SL +       +     +     +    
Sbjct: 1112 E--KEADFLAQEAQL-LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA 1168

Query: 768  DNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTC 827
            + +   ++    Q +S      Y +   A  +  +S    S    +    +G     +  
Sbjct: 1169 EQQPGNQAQAQAQLAS-----LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA 1223

Query: 828  QKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQ----AVQAMYQISQEEHSQLQEQMEK 883
            +  F           P       E V   L KL       Q    + +++  +L+E++  
Sbjct: 1224 RSLFKRG--------PLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275

Query: 884  LLAKQKDLKEELDACEREFKECMECLEKPMAPQND-KNEIKE-------LQTKLRELQLQ 935
              A++  +  EL   +R+  +  E   K    QN  ++E+ E       LQ++LR  +LQ
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335

Query: 936  YQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVK 995
               +  E+  L   +E L  Q++  Q  + + R       + +      +++    + +K
Sbjct: 1336 RMEAQGERELLQAAKENLTAQVEHLQAAVVEAR------AQASAAGILEEDLRTARSALK 1389

Query: 996  MKKVTKPCSDTSESDLETRKSLE-----VVLYYKASQRKLDGLAKE-EEKKEEMEEEKKQ 1049
            +K      ++  ES+ E  ++L+      V   KA Q  L  L +   E++EE+E  + Q
Sbjct: 1390 LK------NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQ 1443

Query: 1050 VKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEK 1090
            ++E  K++   +   E    +  K  ++ +  +E  +E EK
Sbjct: 1444 IQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEK 1484



 Score =  130 bits (327), Expect = 7e-30
 Identities = 233/1208 (19%), Positives = 484/1208 (40%), Gaps = 156/1208 (12%)

Query: 17   EEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETR 76
            E+++   E+EV +  E+ +K  S     + K   L   E E  EL  ++ +   E+E   
Sbjct: 845  EQQKAAHEKEVNQLREKWEKERSWHQQELAK--ALESLEREKMELEMRLKEQQTEMEA-- 900

Query: 77   ELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESEL 136
             +  Q E++  + +  L   +L + ++     + + Q Q EL    +++  L  + + + 
Sbjct: 901  -IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQK 959

Query: 137  KEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEI 196
             + ++   + Q ++Q  ++  +++A +H  D+A+LQE+   +  +  D+++   D + ++
Sbjct: 960  LKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQL 1019

Query: 197  ASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLAD 256
             +      +   E            +QE+L+E +E     N   + L+   +SLT  L +
Sbjct: 1020 VAQDDSQRLVEQE------------VQEKLRETQE----YNRIQKELEREKASLTLSLME 1063

Query: 257  LESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNK 316
             E           ++ Q LS    + Q ++ +  E   +M+LLRQ++++ E      + +
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123

Query: 317  CQELCCELE-------ELQHHRQVSEEEQRRLQRELKCAQNEV----LRFQTSHSVTQNE 365
              E   ELE       +L+      E +  +LQ  L+  ++++       Q  +      
Sbjct: 1124 LLE---ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQA 1180

Query: 366  ELKSRLCTLQKKYDTSQDEQNEL----------------------------LKMQLQLQT 397
            +L S    LQ+   +  + + EL                            L   L  + 
Sbjct: 1181 QLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEA 1240

Query: 398  ELRQLKVMKSTLVENQSEKELL-CRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCH--- 453
                L  +   L + Q  +++L  ++QKL  +  +   EK ++    Q LQ +L  +   
Sbjct: 1241 VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE 1300

Query: 454  -----------EAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMY 502
                       E+EL  L +T+AS +    +      + Q  ++L QA+K+ L  Q    
Sbjct: 1301 KSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ---- 1356

Query: 503  DQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQM 562
                + L    +E +   ++  I E+  + A     L +   E + +   + +E G+L++
Sbjct: 1357 ---VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKV 1413

Query: 563  EQCELLED------------QRRMQEEQGQLQE-----ELHRLTLPLPKSGLLLKSQELL 605
             Q + L++            +  ++  +GQ+QE     E+ +  L L    L  ++QE+ 
Sbjct: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD 1473

Query: 606  TKLEDLCELQL-------LYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVL 658
             + E + EL+        L   +QE ++KL   ++ +   +LE   E +R    H    L
Sbjct: 1474 LQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI--RELEKDRETQRNVLEHQLLEL 1531

Query: 659  ENPDDSKLAKSSKCNRNKQSKLLMEQMQ-ALQVMYDAGQAKQELLQQEQGRLLEERKRLQ 717
            E  D    ++  +    K+  + +E +   L+  +   + +Q+L+++ +G+   +R  L 
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVAL- 1590

Query: 718  ADLQLCLEE-MQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSY 776
              L L LEE  Q LQ QS  I   LES+       +   +   K+    +++ +   +  
Sbjct: 1591 THLTLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL 1649

Query: 777  T-STQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSC 835
            T   +   +  +   +      +   +            K S        T Q+  +   
Sbjct: 1650 TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQE- 1708

Query: 836  TDEEPAEPEDMERFEEMVVKVLIK-----LQAVQAMYQISQEEHSQLQEQMEKLLAKQKD 890
              EE   P   +R     +K++++     ++  Q      QE   QL++Q++ L  K  +
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGE 1768

Query: 891  LKEELDACEREFKECMECLEKPMAPQNDKNEIKE--LQTKLRELQLQYQASMDEQGRLLV 948
                L   E+E    +  L++ +    ++ E+KE  LQ++L E Q        E   L  
Sbjct: 1769 TSLLLSQREQE----IVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQ 1824

Query: 949  VQEQLEGQLQCCQEELRQLR---EKRPSVVKEARG-----KNANKNMNKN--ANGVKMKK 998
             Q+Q +GQ +  +E+   L+   E+    +KE  G     K   + + +     G +++ 
Sbjct: 1825 EQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQA 1884

Query: 999  VTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQC 1058
            + +   D      E  K+L               LA +++  E+ +E + + +       
Sbjct: 1885 LEEVLGDLRAESREQEKAL---------------LALQQQCAEQAQEHEVETRALQDSWL 1929

Query: 1059 GDELVAEPADPE-EAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEEN--NPLR 1115
              + V +  D E EA   E Q    +++    + E  +E    A ++L+  E++      
Sbjct: 1930 QAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAE 1989

Query: 1116 LSESKKSS 1123
            LS S ++S
Sbjct: 1990 LSRSLEAS 1997



 Score =  129 bits (325), Expect = 1e-29
 Identities = 254/1293 (19%), Positives = 521/1293 (40%), Gaps = 205/1293 (15%)

Query: 1    MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRG-LSLTET--- 56
            ++++E E +   +  +E++ E E  + + EEE+ Q   ++  + +   +  +SL ET   
Sbjct: 877  LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936

Query: 57   ----------ELEELRAQV---------------LQLVAELEETRELAGQHEDDSLELQG 91
                      +LE LR  +                QL     E +E A QH DD   LQ 
Sbjct: 937  TQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQ- 995

Query: 92   LLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQ 151
               +E  +  Q      KQ++ L+ +L +  +   L+E E + +L+E  QE +  Q E++
Sbjct: 996  ---EESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET-QEYNRIQKELE 1051

Query: 152  SLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPS 211
              + +   S  E E  +  LQE     Q EL  + +   + + E   L A+ME+   E  
Sbjct: 1052 REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVK 1111

Query: 212  GSLGLSDYSGLQEELQELRERYHFLNEEYRA---------------LQESNSSLTG---- 252
                 +D+   + +L E  E  H   ++ RA               L+ + S L      
Sbjct: 1112 EKE--ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE 1169

Query: 253  -----------QLADLESERTQR------------------------------ATERWLQ 271
                       QLA L S   Q                               A   + +
Sbjct: 1170 QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR 1229

Query: 272  SQTLSMTSAESQTSEMDFLEPD-----PEMQLLRQQLRDAEEQMHGMKNKCQELCCELEE 326
               L+  SAE+  S +  L  D         +LR Q++  EE++   + +  ++  EL++
Sbjct: 1230 GPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQD 1289

Query: 327  LQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQN 386
            LQ     ++EE+ + + +    ++E++     H    + + + R   LQ+     + E  
Sbjct: 1290 LQRQLSQNQEEKSKWEGKQNSLESELMEL---HETMASLQSRLRRAELQRMEAQGERELL 1346

Query: 387  ELLKMQLQLQTELRQLKVMKSTLVENQS---EKELLCRLQKLHLQHQNVTCEKEKLLERQ 443
            +  K  L  Q E  Q  V+++    + +   E++L      L L+++ V  E+E    R 
Sbjct: 1347 QAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE----RA 1402

Query: 444  QQLQEELQCHEAELQHLRDTVASFKES---NEKDTET-HAQLQEMKQLYQASKDELERQK 499
            Q LQE+ +   A+ + L++ +A   ++    E++ ET   Q+QE+++  +  K  LE   
Sbjct: 1403 QALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLS 1462

Query: 500  HMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLS-RLTELQEKYKASQKEMG 558
                +  Q++ L Q +++EL+    + E       + +  L+ +  +++E  K  + +  
Sbjct: 1463 LDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRN 1522

Query: 559  QLQMEQCELLEDQRRMQEEQGQLQE------ELHRLTLPLPKSGLLLKSQELLTK-LEDL 611
             L+ +  EL +  + ++ ++GQ+Q+       L  L L L ++   ++ Q+ L K LE  
Sbjct: 1523 VLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQ 1582

Query: 612  CELQL-----LYQGMQEEQKKL--------------------IQNQDCVLKEQLEIHEEL 646
             E Q      L   ++E  ++L                    +Q +D  +K Q E  EEL
Sbjct: 1583 RETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL 1642

Query: 647  RRFKESHFQEVLENPDDSKLAKSSKCN-----RNKQSKLLMEQMQALQV-MYDAGQ---A 697
            +R KE H  + LE  D   + +  +       R +Q+K+L E ++ +++ + + G+    
Sbjct: 1643 QRQKE-HLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTT 1701

Query: 698  KQELLQQ--EQGR--------LLEERKRLQAD----LQLCLEEMQLLQVQSPSIKMSLES 743
            +++L+Q+  E+G+         LE  K +  D    ++   E +  LQ     ++  L+ 
Sbjct: 1702 QRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQG 1761

Query: 744  YGKSYG--SMVPSNEN-----CRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSA 796
              +  G  S++ S         ++      +  E   +S  S    ++  L   D    A
Sbjct: 1762 LHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA 1821

Query: 797  -----SEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEE 851
                  +A G+       +        G+   +    K       D +    E   R EE
Sbjct: 1822 LQQEQQQAQGQEERVKEKADALQ----GALEQAHMTLKERHGELQDHK----EQARRLEE 1873

Query: 852  MVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEK 911
               ++ ++ + VQA+ ++  +  ++ +EQ + LLA Q+   E+    E E +   +   +
Sbjct: 1874 ---ELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930

Query: 912  PMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKR 971
              A   ++++  EL+    E Q         + R   +QE L G+     +   Q   ++
Sbjct: 1931 AQAVLKERDQ--ELEALRAESQSSRHQEEAARARAEALQEAL-GKAHAALQGKEQHLLEQ 1987

Query: 972  PSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLD 1031
              + +      A    + +A     +++ +      E +++ +     + Y +  Q+   
Sbjct: 1988 AELSRSLEASTATLQASLDACQAHSRQLEEALR-IQEGEIQDQD----LRYQEDVQQLQQ 2042

Query: 1032 GLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKE 1091
             LA+ +E+    +E ++ +++   ++  + ++ E  +  + +  E++E     +   E +
Sbjct: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER--EEEEIRGLHQSVRELQ 2100

Query: 1092 EDSEEEEDDADSSLESPEENNPLRLSESKKSSP 1124
                ++E +     E+ + NN   L  S K+SP
Sbjct: 2101 LTLAQKEQEILELRETQQRNNLEALPHSHKTSP 2133



 Score =  126 bits (316), Expect = 1e-28
 Identities = 235/1191 (19%), Positives = 480/1191 (40%), Gaps = 138/1191 (11%)

Query: 21   EEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAG 80
            E+  +E + +EE + +        V +   L +    +E  R  + + +  L   +EL  
Sbjct: 711  EQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLE 770

Query: 81   QHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEI----SLLEHEKESEL 136
                ++ +   ++E  +     Q +  T+  + +QGE+R L+ E+    S  E E+++  
Sbjct: 771  SSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAA 830

Query: 137  KE-----------IEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELE-- 183
            ++           +EQ+    + E+  LR+  E   + H+ ++A   E L R + ELE  
Sbjct: 831  RQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMR 890

Query: 184  ------DMERIRGDYEME---IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYH 234
                  +ME I+   E E     S   +M++++ +   SL L      Q+EL +  ++  
Sbjct: 891  LKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL-LETLLQTQKELADASQQLE 949

Query: 235  FLNEEYRAL----QESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFL 290
             L ++ +      QE+   L  QL + + E  + A +       L+    ES +   D +
Sbjct: 950  RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ---HRDDLAALQEESSSLLQDKM 1006

Query: 291  EPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQN 350
            +   +++ L+ QL   ++    ++ + QE   E +E    ++  E E+  L   L   + 
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066

Query: 351  EVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLV 410
             +L  Q + S+ Q E     L  L++    +Q EQ E     L  Q EL + +V +    
Sbjct: 1067 RLLVLQEADSIRQQE-----LSALRQDMQEAQGEQKE-----LSAQMELLRQEVKEKEAD 1116

Query: 411  ENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKES 470
                E +LL  L+  H+  Q +         +  QLQ  L+  E++L+ L    A  +  
Sbjct: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL---AAEQQPG 1173

Query: 471  NEKDTET-----HAQLQEMKQLYQASKDELE--------------RQKHMYDQLEQDLLL 511
            N+   +      ++ LQ+       S+ EL                Q       ++  LL
Sbjct: 1174 NQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLL 1233

Query: 512  CQLELKEL-KASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED 570
              L  + +  A H + +D  K     D L  ++ +L+E+   ++ E  Q+  E  +L   
Sbjct: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ 1293

Query: 571  QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ 630
              + QEE+ + + + + L         L++  E +  L+       L +   + +++L+Q
Sbjct: 1294 LSQNQEEKSKWEGKQNSL------ESELMELHETMASLQSRLRRAELQRMEAQGERELLQ 1347

Query: 631  NQDCVLKEQLEIHEE--LRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQAL 688
                 L  Q+E  +   +    ++    +LE  +D + A+S+   +N++ +   E+ QAL
Sbjct: 1348 AAKENLTAQVEHLQAAVVEARAQASAAGILE--EDLRTARSALKLKNEEVESERERAQAL 1405

Query: 689  QVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKS- 747
            Q   +   A+ + LQ+    L +     + +++    ++Q L+ Q    K +LE      
Sbjct: 1406 QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDL 1465

Query: 748  ---------YGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE 798
                         +   E CR   +      +   +  T  +   +   K  ++  +  E
Sbjct: 1466 KKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLE 1525

Query: 799  AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLI 858
                            +   G     D  ++     C   E  E       ++ ++K L 
Sbjct: 1526 ---HQLLELEKKDQMIESQRGQV--QDLKKQLVTLECLALELEENHHKMECQQKLIKELE 1580

Query: 859  KLQAVQAM----YQISQEEHSQ-LQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPM 913
              +  Q +      +  EE SQ LQ Q  ++     DL+       RE +      E+  
Sbjct: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQI----HDLESHSTVLARELQ------ERDQ 1630

Query: 914  APQNDKNEIKELQTK----LRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ--- 966
              ++ + +I+ELQ +     ++L+ + Q  M ++ R+ V+++Q   Q +  +E+L Q   
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL 1690

Query: 967  -LREKRPSVVKEAR--------GKNANKNMNKNANGVKM----KKVTKPCSDTSESDL-E 1012
             LRE+   +  + +        GK  +K    +   +K+    K+    C      +L E
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750

Query: 1013 TRKSLEVV---LYYKASQRKLDGLAKEEEKKEEMEEEKKQVKE--EAKEQCGDELVAEPA 1067
             +  LE     L+ K  +  L  L++ E++   ++++ ++ +E  E KEQ    L ++  
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSL-LLSQREQEIVVLQQQLQEAREQGELKEQ---SLQSQLD 1806

Query: 1068 DPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSE 1118
            + + A +  DQE     +E+++ +   E  ++ AD +L+   E   + L E
Sbjct: 1807 EAQRALAQRDQELEALQQEQQQAQGQEERVKEKAD-ALQGALEQAHMTLKE 1856



 Score =  110 bits (274), Expect = 1e-23
 Identities = 240/1207 (19%), Positives = 485/1207 (40%), Gaps = 176/1207 (14%)

Query: 1    MQAMEGEVL--LPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLT-ETE 57
            ++A + E L  L  L E  E    E E + +E+ +V    +    S+ +      T +TE
Sbjct: 531  LEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTE 590

Query: 58   LEELRAQVLQLVA-----------------ELEETRELAGQHEDDSLELQGLLEDERLAS 100
            + +LRA  ++L A                 +LEE  +      + + + +  L+ +   +
Sbjct: 591  VADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEA 650

Query: 101  AQQAEVFTKQIQQLQGELRSLRE-------EISLLEHEKESELKEIEQELHLAQAEIQSL 153
             ++ E   ++   L+ +L+   E       ++  ++ EKE   K++ +  H  +A    L
Sbjct: 651  EKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQL 710

Query: 154  RQAAEDSATEHESDIASLQE------DLCRMQNELEDMERIRGDYEMEIASLRAEMEMKS 207
             Q  +++  + E    ++QE      +   ++  L+ +ER R D   ++  L +  E+  
Sbjct: 711  EQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLE 770

Query: 208  S-----EPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERT 262
            S     +   S+       L+ ++Q + +    +  E R L+           +L++ER+
Sbjct: 771  SSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK----------LELDTERS 820

Query: 263  QRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQ-ELC 321
            Q   ER   ++ L+    E +T+             L QQ    E++++ ++ K + E  
Sbjct: 821  QAEQERDAAARQLAQAEQEGKTA-------------LEQQKAAHEKEVNQLREKWEKERS 867

Query: 322  CELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTS 381
               +EL    +  E E+  L+  LK  Q E+   Q      +  + +S LC         
Sbjct: 868  WHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE-EERTQAESALC--------- 917

Query: 382  QDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLE 441
                      Q+QL+TE  ++ ++++ L   Q++KEL    Q+L    Q++  +K K  E
Sbjct: 918  ----------QMQLETEKERVSLLETLL---QTQKELADASQQLERLRQDMKVQKLKEQE 964

Query: 442  R----QQQLQE-ELQCHEAELQHLRDTVASFKESN---EKDTETHAQLQEMKQLYQASKD 493
                 Q QLQE + +  EA  QH  D  A  +ES+   +   +   Q++++K    A  D
Sbjct: 965  TTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024

Query: 494  -----ELERQKHMYDQLEQDLLLCQLELKELKASHPI----PEDKGKCANKCDTL----L 540
                 E E Q+ + +  E + +  Q EL+  KAS  +     E +     + D++    L
Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRI--QKELEREKASLTLSLMEKEQRLLVLQEADSIRQQEL 1082

Query: 541  SRLTELQEKYKASQKEM-GQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLL 599
            S L +  ++ +  QKE+  Q+++ + E+ E +     ++ QL EEL    +   +    L
Sbjct: 1083 SALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142

Query: 600  KSQELLTKLEDL----CELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQ 655
             +QE       L     E QL     +++     Q Q  +      + + L    ES   
Sbjct: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR-P 1201

Query: 656  EVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKR 715
            E+    D +      + ++N    L         +  +A  +    L Q+  +  + R  
Sbjct: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261

Query: 716  LQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKS 775
            L+  +Q   E +   + +   +   L+   +     +  N+  +  ++   +  ES    
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQR----QLSQNQEEKSKWEGKQNSLESELME 1317

Query: 776  YTSTQTSSKSFLKSYDSSTSASEAYG-KSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSS 834
               T  S +S L+   +     EA G +     +  ++T +  +   +  +   ++  + 
Sbjct: 1318 LHETMASLQSRLRR--AELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAG 1375

Query: 835  CTDEEPAEPEDMERFE-EMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKE 893
              +E+        + + E V     + QA+Q   ++   +   LQE +  L     + +E
Sbjct: 1376 ILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREE 1435

Query: 894  ELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQL 953
            E++    + +E    LEK    Q    E+  L  K R  ++  Q            QEQ+
Sbjct: 1436 EVETLRGQIQE----LEKQREMQKAALELLSLDLKKRNQEVDLQ------------QEQI 1479

Query: 954  EGQLQCCQEELRQL------REKRPSVVKE-ARGKNANKNMNKNANGVKMKKVTKPCSDT 1006
            + +L+ C+  L  L      RE++ +V +E  R    ++   +N    ++ ++ K     
Sbjct: 1480 Q-ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK----- 1533

Query: 1007 SESDLETRKSLEVVLYYKASQRKLDGLAKE-EEKKEEMEEEKKQVKE-EAK--------- 1055
             +  +E+++    V   K     L+ LA E EE   +ME ++K +KE E +         
Sbjct: 1534 KDQMIESQRG--QVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591

Query: 1056 ------EQCGDELVAEPADPEEAKS------TEDQEENEEDKEEEEKEEDSEEEEDDADS 1103
                  E+   EL A+ +   + +S       E QE ++E K + E+ E+ + +++    
Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651

Query: 1104 SLESPEE 1110
             LE  ++
Sbjct: 1652 DLERRDQ 1658



 Score =  103 bits (258), Expect = 7e-22
 Identities = 220/1108 (19%), Positives = 446/1108 (40%), Gaps = 179/1108 (16%)

Query: 123  EEISLLEHEKESELKEIEQELHLAQAEIQ-------------------------SLRQAA 157
            +E+    HE+  EL +++ +  L +AE+Q                         +LR+  
Sbjct: 254  QELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETV 313

Query: 158  EDSAT------EHESDIA-SLQEDLCRMQNELEDMERIRGDYEMEIA------------- 197
            E   T      EHE+ ++ + QE+   +Q  ++D+ ++  +    IA             
Sbjct: 314  EILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDS 373

Query: 198  SLRAEMEMKSSEPSGSLGLSDYSGLQEELQELR-------ERYHFLNEEYRALQESNSSL 250
            S+ ++ + + ++ + +L  S  +  ++ +Q+LR       E  + L +++   +E   +L
Sbjct: 374  SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433

Query: 251  TGQLADLESERTQRATERWLQSQTLSMT-SAESQTSEMDFLEPDPEMQLLRQQLRDAEEQ 309
              +L  L  ER        L  QT+ +    +S + E + L+   E   LRQQL   E++
Sbjct: 434  RQRLQKLTGERDT------LAGQTVDLQGEVDSLSKERELLQKAREE--LRQQLEVLEQE 485

Query: 310  MHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKS 369
               ++    EL  + +  Q  ++  +EE     RE +  Q  ++  +   S     E  S
Sbjct: 486  AWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQS-----ESLS 540

Query: 370  RLCTLQKKYDTS-------QDEQNELLKMQLQLQTELRQLKVMKSTL-----------VE 411
             L TL++  ++S       + EQ E+     + +  + +L   ++TL           V+
Sbjct: 541  ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600

Query: 412  NQSEKELLCRLQKLHLQHQNVTCEKE-----KLLERQQQLQEELQCHEAELQHLRDTV-- 464
              +  E L  L K+ L  Q +  E+E       +E  +Q +  LQ   AE +  R+ +  
Sbjct: 601  LSALNEALA-LDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE 659

Query: 465  ------ASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKE 518
                  A  +++ E   E  A L+++++  +  + +L   +H     +Q+    QLE   
Sbjct: 660  KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH-----QQEAATTQLEQLH 714

Query: 519  LKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEE- 577
             +A     E   +   + + L+     L+ + +A +++   L  EQ + L   + + E  
Sbjct: 715  QEAKRQ-EEVLARAVQEKEALVREKAALEVRLQAVERDRQDL-AEQLQGLSSAKELLESS 772

Query: 578  --QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLC--ELQLLYQGMQEEQKKLIQNQD 633
              + Q Q  +  +T      G L    + +T+ +++   E++ L   +  E+ +  Q +D
Sbjct: 773  LFEAQQQNSVIEVT-----KGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD 827

Query: 634  CVLKEQLEIHEE----LRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLL----MEQM 685
               ++  +  +E    L + K +H +EV  N    K  K    ++ + +K L     E+M
Sbjct: 828  AAARQLAQAEQEGKTALEQQKAAHEKEV--NQLREKWEKERSWHQQELAKALESLEREKM 885

Query: 686  QALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQL-LQVQSPSIKMSLESY 744
            + L++     Q + E +Q ++     E +R QA+  LC  +MQL  + +  S+  +L   
Sbjct: 886  E-LEMRLKEQQTEMEAIQAQR-----EEERTQAESALC--QMQLETEKERVSLLETLLQT 937

Query: 745  GKSYGSMVPSNENCRKTYDT-TVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKS 803
             K         E  R+      + + E+     T  Q + +   ++         A  + 
Sbjct: 938  QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997

Query: 804  YCTTSNSSITYKKSYGSTSSSDTCQ---KSFVSSCTDEEPAEPEDMERFEE--------M 852
              +     +  +K      S    Q   +  V     E+  E ++  R ++        +
Sbjct: 998  SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057

Query: 853  VVKVLIK---LQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKEC---- 905
             + ++ K   L  +Q    I Q+E S L++ M++   +QK+L  +++   +E KE     
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117

Query: 906  ----MECLEKPMAPQNDKNEIK-----------ELQTKLR--ELQLQYQASMDEQGRLLV 948
                 + LE+  A    + +++           +LQ +LR  E QL+  A+  + G    
Sbjct: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177

Query: 949  VQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVK--MKKVTKPCSDT 1006
             Q QL       Q+ L  + E RP +        +   +  + NG +   K+     + +
Sbjct: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237

Query: 1007 SESDLETRKSLEVVLYYKASQRKL--DGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVA 1064
            +E+       L   L+     R +  D + K EE+  + E EK QV  E +     +L  
Sbjct: 1238 AEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQ-----DLQR 1292

Query: 1065 EPADPEEAKSTEDQEENEEDKEEEEKEE 1092
            + +  +E KS  + ++N  + E  E  E
Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHE 1320



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 161/806 (19%), Positives = 323/806 (40%), Gaps = 101/806 (12%)

Query: 8    VLLPALYEEEEEEEEEEEEVEE---------------EEEQVQKGGSVGSLSVNKHRGLS 52
            VL   L E ++E + + E++EE               ++E + +   +  L   + R   
Sbjct: 1620 VLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTK 1679

Query: 53   LTETELEELRAQVLQLVAELEETRELAGQHEDD----SLELQGLLEDERLA---SAQQAE 105
            + E +LE+++  + +   EL   R+L  +  ++    S   +G LE  +L      ++ E
Sbjct: 1680 ILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE 1739

Query: 106  VFTKQIQQLQGELRSLREEISLLEHEKESE----LKEIEQELHLAQAEIQSLRQAAEDSA 161
               + I +LQ     L +++  L H K  E    L + EQE+ + Q ++Q  R+  E   
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGL-HRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE 1798

Query: 162  TEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEME-MKSSEPSGSLGLSDYS 220
               +S +   Q  L +   ELE +++ +   + +   ++ + + ++ +     + L +  
Sbjct: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858

Query: 221  GLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSA 280
            G   ELQ+ +E+   L EE         +L   L DL +E          + Q  ++ + 
Sbjct: 1859 G---ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES---------REQEKALLAL 1906

Query: 281  ESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRR 340
            + Q +E    E + E + L+     A+  +     + + L  E +  +H  + +      
Sbjct: 1907 QQQCAE-QAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA 1965

Query: 341  LQRELKCAQNEVLRFQTSHSVTQNE---ELKSRLCTLQKKYDTSQD-----------EQN 386
            LQ  L  A +  L+ +  H + Q E    L++   TLQ   D  Q            ++ 
Sbjct: 1966 LQEALGKA-HAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEG 2024

Query: 387  ELLKMQLQLQTELRQLK---VMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQ 443
            E+    L+ Q +++QL+     +   + +Q E+E L          +N+  EK+ L   Q
Sbjct: 2025 EIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNL--GQ 2082

Query: 444  QQLQEELQCHEAELQHLRDTVASFKES--NEKDTETHAQLQEMKQLYQASKDELERQKHM 501
            ++ +EE++     ++ L+ T+A  ++     ++T+    L+ +   ++ S   +E Q   
Sbjct: 2083 EREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTS--PMEEQSLK 2140

Query: 502  YDQLEQDLLLCQLELKELKASHPIPEDKG-KCANKCDTLLSRLTELQEKYKASQKEMGQL 560
             D LE  L   Q EL+ L+A+    E +  +   K   L   L + +    + Q+    L
Sbjct: 2141 LDSLEPRL---QRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFL 2197

Query: 561  QMEQCELLEDQRRMQEEQGQLQEELHRLTLPLP------------KSGLLL--------- 599
            Q    E   +Q+R+Q+E    +  L +  L  P            + G+ L         
Sbjct: 2198 QASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAE 2257

Query: 600  ------KSQELLTKLEDL----CELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRF 649
                  + Q    +LE L      L++    +Q    +L    + V +E+ ++  E  R 
Sbjct: 2258 PSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRA 2317

Query: 650  KESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRL 709
             ++   E+ +    S   +  +  +N  +K + E +Q   V+  A    +   +Q+    
Sbjct: 2318 AQAGSLEISKATASSPTQQDGRGQKNSDAKCVAE-LQKEVVLLQAQLTLERKQKQDYITR 2376

Query: 710  LEERKRLQADLQLCLEEMQLLQVQSP 735
              +  R  A L   L    L   Q+P
Sbjct: 2377 SAQTSRELAGLHHSLSHSLLAVAQAP 2402



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 164/874 (18%), Positives = 332/874 (37%), Gaps = 117/874 (13%)

Query: 293  DPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEV 352
            +P +  L  +L + +++   +     +L   +E+     +   E+  +L  +   A++E+
Sbjct: 93   EPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDEL 152

Query: 353  LRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVEN 412
            +R ++   + Q E  K  L          + E   LL +  ++ T  R    MKS     
Sbjct: 153  MRKESQWQMEQ-EFFKGYL----------KGEHGRLLSLWREVVTFRRHFLEMKSA---- 197

Query: 413  QSEKELL-CRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESN 471
             ++++L+  + + + L    +TC                 C       LR TV +  +S 
Sbjct: 198  -TDRDLMELKAEHVRLSGSLLTC-----------------C-------LRLTVGA--QSR 230

Query: 472  EKDTETHAQLQEMKQLYQ--ASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDK 529
            E +       +E  QL    A   ELE++ H   Q          EL +LK+   +  +K
Sbjct: 231  EPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQ----------ELIQLKSQGDL--EK 278

Query: 530  GKCANKCDTLLSRLTELQEK-------YKASQKEMGQLQMEQCELLEDQ----RRMQEEQ 578
             +  ++   L + LT+ Q++        KA ++ +  L+    EL+E +    R  QEE+
Sbjct: 279  AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338

Query: 579  GQLQEELHRLTLPLPKSGLLL---KSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCV 635
              LQ+ +  +T  + + G  +      E   +L+     Q  YQ    +  K +     V
Sbjct: 339  LSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQ----DADKALTLVRSV 394

Query: 636  LKEQLEIHEELRRFKESHFQEV-LENPDDSKLAKSSKCNRNKQSKLLME------QMQAL 688
            L  + +  ++LR+      + V L      +  +  K  R +  KL  E      Q   L
Sbjct: 395  LTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDL 454

Query: 689  QVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSY 748
            Q   D+   ++ELLQ+ +  L ++ + L+ +          LQ+Q  S +   E   +  
Sbjct: 455  QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL 514

Query: 749  GSMVPSNENCRKTY-DTTVDDNESYYKSYTSTQTSSKSFLKS------YDSSTSASEAYG 801
               V   E  ++         +ES  +  T  +    S L+           T+A     
Sbjct: 515  HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAE 574

Query: 802  KSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQ 861
            +S    S+S  T K       ++     +   +   ++    + + + EE    V  +++
Sbjct: 575  QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRME 634

Query: 862  AVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNE 921
            A +      Q + ++ +++ E L  K   L+ +L   E    E                +
Sbjct: 635  AAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQA-------------D 681

Query: 922  IKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARG- 980
            ++++Q +  E+Q +   S  +Q       EQL  + +  +E L +  +++ ++V+E    
Sbjct: 682  LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741

Query: 981  -------KNANKNMNKNANGVKMKKVTKPCS----DTSESDLETRKSLEVVLYYKASQRK 1029
                   +   +++ +   G+   K     S        S +E  K    V     +Q K
Sbjct: 742  EVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801

Query: 1030 LDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADP---EEAKSTEDQEENEEDKE 1086
                 +    K E++ E+ Q ++E          AE       E+ K+  ++E N+  ++
Sbjct: 802  EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK 861

Query: 1087 EEEKEEDSEEEEDDADSSLESPEENNPLRLSESK 1120
             E++    ++E   A  SLE  +    +RL E +
Sbjct: 862  WEKERSWHQQELAKALESLEREKMELEMRLKEQQ 895


>gi|56550043 sarcolemma associated protein [Homo sapiens]
          Length = 811

 Score =  134 bits (336), Expect = 7e-31
 Identities = 106/351 (30%), Positives = 183/351 (52%), Gaps = 23/351 (6%)

Query: 13  LYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAEL 72
           L   +E+  ++  + + +E+ + +  +  SL  +  +G    ++E+E  + ++  L  EL
Sbjct: 434 LSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQG---AQSEIEA-KQEIQHLRKEL 489

Query: 73  EETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEK 132
            E +ELA   +    ELQ LLE+ER A   Q E  TKQIQ LQ +L+ L  +   L  EK
Sbjct: 490 IEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEK 549

Query: 133 ESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDY 192
           +SE+     EL  A+ EI  L QAA   A+E ++DIASLQE+L +++ ELE   +   +Y
Sbjct: 550 DSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEY 609

Query: 193 EMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTG 252
           E EI SL+   +++  +        + + LQ EL++LR+ ++ L  E  +L+  N  L+ 
Sbjct: 610 EKEITSLQNSFQLRCQQCEDQ-QREEATRLQGELEKLRKEWNALETECHSLKRENVLLSS 668

Query: 253 QLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQ-LRD------ 305
           +L   E E          Q Q+L +TS +    +M   E + ++  L++Q LRD      
Sbjct: 669 ELQRQEKELHNS------QKQSLELTS-DLSILQMSRKELENQVGSLKEQHLRDSADLKT 721

Query: 306 ----AEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEV 352
               AE Q   ++ + ++    L EL+   +++E+E++ +  ELK  +N +
Sbjct: 722 LLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 128/580 (22%), Positives = 237/580 (40%), Gaps = 99/580 (17%)

Query: 10  LPALYEEEEEEEEEEEE-----VEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQ 64
           L AL E++   E   +E     ++E+ E V+K   V        R LS TE E   L+  
Sbjct: 240 LIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEV-------ERSLSNTEDECTHLKEM 292

Query: 65  VLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREE 124
             +     EE RELA ++     E++ L +  ++A  +Q E+  K     Q E + L+ +
Sbjct: 293 NERTQ---EELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKG----QAEKKELQHK 345

Query: 125 ISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDL-------CR 177
           I         E++E EQEL   QA+I++L QA  D   E    + +LQE L       C 
Sbjct: 346 ID--------EMEEKEQEL---QAKIEAL-QADNDFTNER---LTALQEHLLSKSGGDCT 390

Query: 178 MQNELEDMER---IRGDYEMEIASLRAEME----MKSSEPSGSLGLSDYSGLQEELQELR 230
             ++  + ++   + G     +   +   E     K S+ S +L  S      ++  + +
Sbjct: 391 FIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKS-SDDTTDAQ 449

Query: 231 ERYHFLNEEYRALQESNSSLTGQLADLESERT-QRATERWLQSQTLSMTSAESQTSEMDF 289
                LNE    +      L G  +++E+++  Q   +  +++Q L+ TS +        
Sbjct: 450 MDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQAL 509

Query: 290 LEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQ 349
           LE   E +  R Q+ ++ +Q+  ++ + Q L  + E L   R+  + E    + EL  A+
Sbjct: 510 LEE--ERKAYRNQVEESTKQIQVLQAQLQRLHIDTENL---REEKDSEITSTRDELLSAR 564

Query: 350 NEVLRFQTSHS----------VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTEL 399
           +E+L    + +           +  EELK     L++    + + + E+  +Q   Q   
Sbjct: 565 DEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRC 624

Query: 400 RQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQH 459
           +Q +       + +    L   L+KL  +   +  E   L      L  ELQ  E EL +
Sbjct: 625 QQCEDQ-----QREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHN 679

Query: 460 ---------------------LRDTVASFKESNEKDT--------ETHAQLQEMKQLYQA 490
                                L + V S KE + +D+        +   Q +++++ Y+ 
Sbjct: 680 SQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEK 739

Query: 491 SKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKG 530
           ++  L   K  ++  EQ+      ELK+ K +  +  +KG
Sbjct: 740 TQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKG 779



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 147/667 (22%), Positives = 271/667 (40%), Gaps = 120/667 (17%)

Query: 112 QQLQGELRSLREEISLLEHEKESELKE-IEQELHLAQAEIQSLR-QAAEDSATEHESDIA 169
           Q L+ +L +L+  +++ +   ++  +  I+++  L++ E+   + QA   + TE      
Sbjct: 180 QMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTED----- 234

Query: 170 SLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQEL 229
           SL+++L  +Q +  + E    +    +   + E+  K SE   SL     S  ++E   L
Sbjct: 235 SLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSL-----SNTEDECTHL 289

Query: 230 RERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDF 289
           +E      EE R L    +    ++ DL  +                             
Sbjct: 290 KEMNERTQEELRELANKYNGAVNEIKDLSDK----------------------------- 320

Query: 290 LEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQ 349
                        L+ AE +   ++ K Q    E +ELQH     EE+++ LQ +++  Q
Sbjct: 321 -------------LKVAEGKQEEIQQKGQ---AEKKELQHKIDEMEEKEQELQAKIEALQ 364

Query: 350 NEVLRFQTSHSVTQNEELKSRL---CTL-------QKK--YDTSQDEQNELLKMQLQLQT 397
            +   F         E L S+    CT        QKK   +    +  E  K+  + QT
Sbjct: 365 AD-NDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQT 423

Query: 398 ELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQ-QQLQEELQCHEAE 456
             ++      TL  ++ +        ++  Q  N    K  LL+   Q  Q E++  + E
Sbjct: 424 RAKE-SDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQ-E 481

Query: 457 LQHLRDTVASFKE----SNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLC 512
           +QHLR  +   +E    S +K  E  A L+E ++ Y+   +E  +Q  +     Q L + 
Sbjct: 482 IQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHID 541

Query: 513 QLELKELKASH----------------PIPEDKGKCANKCDTLLSRLTELQEKYKAS--- 553
              L+E K S                  + +   K A++ DT ++ L E  +K +A    
Sbjct: 542 TENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELER 601

Query: 554 --------QKEMGQLQME---QCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQ 602
                   +KE+  LQ     +C+  EDQ+R  EE  +LQ EL +L     K    L+++
Sbjct: 602 WRKAASEYEKEITSLQNSFQLRCQQCEDQQR--EEATRLQGELEKLR----KEWNALETE 655

Query: 603 ELLTKLEDLCELQLLYQGMQEEQKKL--IQNQDCVLKEQLEIHEELRRFKESHFQEVLE- 659
               K E++    LL   +Q ++K+L   Q Q   L   L I +  R+  E+    + E 
Sbjct: 656 CHSLKRENV----LLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQ 711

Query: 660 NPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQAD 719
           +  DS   K+       Q+K + ++ +  Q +    + K E+ +QE+  + +E K+ + +
Sbjct: 712 HLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNN 771

Query: 720 LQLCLEE 726
           L+L  E+
Sbjct: 772 LKLLREK 778



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 135/655 (20%), Positives = 267/655 (40%), Gaps = 101/655 (15%)

Query: 363 QNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLV---ENQSEKELL 419
           + + L+ +L TLQ+    +Q+  +   +  +     L +L+VM + L    +NQ+E  L 
Sbjct: 178 REQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLR 237

Query: 420 CRLQKLHL-QHQNVTCEKEKL---LERQQQLQEELQCHEAELQHLRDTVASFKESNEKDT 475
             L  L   +H   T  KE L   L+ + ++  +L   E  L +  D     KE NE+  
Sbjct: 238 KELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNER-- 295

Query: 476 ETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANK 535
            T  +L+E+   Y  + +E++        L   L + + + +E+       + KG+   K
Sbjct: 296 -TQEELRELANKYNGAVNEIK-------DLSDKLKVAEGKQEEI-------QQKGQAEKK 340

Query: 536 CDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKS 595
                    ELQ K    +++  +LQ +   L  D     E    LQE L      L KS
Sbjct: 341 ---------ELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHL------LSKS 385

Query: 596 GLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELR-RFKESHF 654
           G                +   ++Q ++ ++K +++       E+ ++ +E + R KES F
Sbjct: 386 G---------------GDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDF 430

Query: 655 QEVL-----ENPDDSKLAKSSKCNRNK---QSKLLMEQMQALQVMYDAGQ----AKQELL 702
            + L     ++ DD+  A+  + + N+   +  LL + +Q  Q   +A Q     ++EL+
Sbjct: 431 SDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELI 490

Query: 703 QQE-------------QGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYG 749
           + +             Q  L EERK  +  ++   +++Q+LQ Q   + +  E+  +   
Sbjct: 491 EAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKD 550

Query: 750 SMVPS-NENCRKTYDTTVDDNESYYK-------SYTSTQTSSKSFLKSYDSSTSASEAYG 801
           S + S  +      D  +  +++  K          S Q   K      +    A+  Y 
Sbjct: 551 SEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYE 610

Query: 802 KSYCTTSNS-SITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKL 860
           K   +  NS  +  ++         T  +  +     E  A   +    +   V +  +L
Sbjct: 611 KEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSEL 670

Query: 861 QAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACE----REFKECMECLEKPMAPQ 916
           Q  +     SQ++  +L   +  L   +K+L+ ++ + +    R+  +    L K     
Sbjct: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQA 730

Query: 917 ND-KNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
            D + E ++ QT L EL+L+++ +  E       ++ +  +L+ C+  L+ LREK
Sbjct: 731 KDVQKEYEKTQTVLSELKLKFEMTEQE-------KQSITDELKQCKNNLKLLREK 778



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 139/682 (20%), Positives = 272/682 (39%), Gaps = 62/682 (9%)

Query: 482  QEMKQLYQASKDELERQKHMYDQLE--QDLLLCQLELKELKASHPIPEDKGKCANKCDTL 539
            QE+ QL Q  ++ L R++ +  +L   Q LL    E  +      I ED+         L
Sbjct: 163  QELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDR---------L 213

Query: 540  LSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHR-LTLPLPKSGLL 598
            LSRL  +  + +A  K   +  + + EL+  Q      +   +E L R L   +     L
Sbjct: 214  LSRLEVMGNQLQACSKNQTEDSLRK-ELIALQEDKHNYETTAKESLRRVLQEKIEVVRKL 272

Query: 599  LKSQELLTKLEDLC-ELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEV 657
             + +  L+  ED C  L+ + +  QEE ++L    +  + E  ++ ++L+         V
Sbjct: 273  SEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLK---------V 323

Query: 658  LENPDDSKLAKSSKCNRNKQSKL--LMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKR 715
             E   +    K     +  Q K+  + E+ Q LQ   +A QA  +   +    L E    
Sbjct: 324  AEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHL-- 381

Query: 716  LQADLQLCLEEMQLLQVQSPSIKMSLESY-GKSYGSMVPSNENCRKTYDTTVDDNESYYK 774
            L      C    Q ++ Q    K+ +E +  K+      S EN  +  ++   D  S  K
Sbjct: 382  LSKSGGDCTFIHQFIECQK---KLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSK 438

Query: 775  SYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSS----SDTCQKS 830
              +S  T+     +   +   A  +  K     + S I  K+           +    ++
Sbjct: 439  EKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELART 498

Query: 831  FVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKD 890
                C + +    E+ + +   V +   ++Q +QA  Q    +   L+E+ +  +   +D
Sbjct: 499  SKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRD 558

Query: 891  LKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLR----ELQLQYQASMDEQGRL 946
               EL +   E     +   K +A + D  +I  LQ +L+    EL+   +A+ + +  +
Sbjct: 559  ---ELLSARDEILLLHQAAAK-VASERD-TDIASLQEELKKVRAELERWRKAASEYEKEI 613

Query: 947  LVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGK-NANKNMNKNANGVKMKKVTKPCSD 1005
              +Q   + + Q C+++ R+   +    +++ R + NA   +    + +K + V      
Sbjct: 614  TSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNA---LETECHSLKRENVLL---- 666

Query: 1006 TSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAE 1065
               S+L+ R+  E+    K S      L+  +  ++E+E +   +KE+      D     
Sbjct: 667  --SSELQ-RQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLL 723

Query: 1066 PADPEEAKSTEDQEENEED--KEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSS 1123
                 +AK  + + E  +    E + K E +E+E+      L+  + N  L L E   + 
Sbjct: 724  SKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKL-LREKGNNK 782

Query: 1124 PTPNPPIFSLPLVGLVVISALL 1145
            P P  P+    L  LV ++A++
Sbjct: 783  PWPWMPM----LAALVAVTAIV 800


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  132 bits (331), Expect = 2e-30
 Identities = 258/1235 (20%), Positives = 489/1235 (39%), Gaps = 136/1235 (11%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            Q+ E E+   A   + E  E     +EEE   V+    +   +  + RG +  E EL+ L
Sbjct: 1427 QSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVR----LQLEATERQRGGA--EGELQAL 1478

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
            RA+     AE  E ++   Q E + L  Q   E +R    +QAEV  +   +++ E  + 
Sbjct: 1479 RAR-----AEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV--ELASRVKAEAEAA 1528

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            RE+   L+  +E  L+  E E  L QAE++  RQ      T   S  A LQ        +
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 182  LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHF-LNEEY 240
               +ER   +  + +A LR E E ++ + +      +    +EE +   ER+    NE  
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQA------EAERAREEAERELERWQLKANEAL 1642

Query: 241  RA-LQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
            R  LQ    +    LA  E+E+ +   ER    +      AE Q      L  + E++  
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKEEAER----EARRRGKAEEQAVRQRELA-EQELEKQ 1697

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA--QNEVLRFQT 357
            RQ      +Q    + +   L  E E+ +  RQ+ EEE  RLQRE   A  + + L  + 
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757

Query: 358  SHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE 417
            +    + E L +     +++  ++ ++  + L+ +     EL +       L E    + 
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817

Query: 418  LLCR--LQKLHLQHQNVTCEKEKLLERQQQLQEE----LQCHEAELQHLR----DTVASF 467
             L      +   + + V  EK   +    +L+ E    L+  EAE + LR    D     
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877

Query: 468  KESNEKDTETHAQLQE-MKQLYQASKDELERQKHMYD-------QLEQDLLLCQLELKEL 519
            +   E+  +  A ++E + QL +AS  ELERQK + +       Q+E+++L  +   ++ 
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 520  KASHPIPE-DKGKC-ANKCDTLLSR-----------------------LTELQEKYKASQ 554
             A     E + G+  +N  DTL S+                         E  +K  A++
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 555  KEMGQLQMEQCELLEDQRRMQEEQGQL-----QEELHRLTLPLPKSGLLLKSQELLTKLE 609
            +E  + +    E +E  +   EE  +L     QE   +L L    +   L+++E      
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057

Query: 610  DLCELQLLYQGMQEEQKKL--IQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLA 667
               + Q L Q +Q+EQ  L  ++ +    +   E  EE R   E    +     ++++  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117

Query: 668  KSS---KCNRNKQSKLLMEQM--QALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQL 722
            K S   +     Q++   E++  +A Q      QA+Q  L+Q+Q    E  K  +   Q 
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177

Query: 723  CLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTS 782
              ++ Q+ Q +  ++++ LE        +    +  +              +   S +  
Sbjct: 2178 LRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236

Query: 783  SKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAE 842
             +   K      +  EA  ++       +        +       +++   S   +E A 
Sbjct: 2237 MEELSKL----KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292

Query: 843  -----PEDMERFEEMVVKVLI-KLQAVQ------AMYQISQEEHSQLQEQMEKLLAKQKD 890
                  ED+ +   +  K+L  K+QAVQ      A  ++ Q++    QEQ  +L   ++ 
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352

Query: 891  LKEELDACEREFKECMEC-----LEKPMAPQNDKNEIKEL---QTKLRELQLQYQASMDE 942
            + ++L    + F+  +E      LE     +  K  + E+   Q +  E   +++   +E
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412

Query: 943  QGRLL-----------VVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNM---- 987
             G  L            + + LE Q Q    +  +LRE    + +E         +    
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472

Query: 988  NKNANGVKMKKVTKPCSDTSESDLETRKSL-EVVLYYKASQRKLDGLAKEEEKKEEMEEE 1046
            ++    V+ +++ +      +S L  + SL +   + +  + KL+ L ++E  K +   E
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532

Query: 1047 KKQVKEEAKEQCGDELVA-------EPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEED 1099
            ++Q +++  EQ    LVA          + EE    + +E  + +++  ++EE   EE  
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592

Query: 1100 DADSSLESPEENNPLRLSESKKSSPTPNPPIFSLP 1134
                 L+  EE +   L+ S++ + +      +LP
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 218/1125 (19%), Positives = 442/1125 (39%), Gaps = 149/1125 (13%)

Query: 55   ETELEELRAQVLQLVAELEETREL-----AGQHEDDSLELQ-GLLEDERLASAQQAEVFT 108
            + E+E L   V +L AE E+   L     A       LEL  G LE  R  SA    ++ 
Sbjct: 1030 QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA----IYL 1085

Query: 109  KQIQQLQGELRSLREEISLLEHEKESELKEIEQ------ELHLAQAEIQSLRQAAEDSAT 162
            ++++ +   +R  +    +L   +E +LKE +       EL   +A ++ LR  AE    
Sbjct: 1086 EKLKTISLVIRGTQGAEEVLRAHEE-QLKEAQAVPATLPELEATKASLKKLRAQAE---- 1140

Query: 163  EHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGL 222
              +    +L+++L   Q   E +++  G+ ++E+   R  +          L  +D    
Sbjct: 1141 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-- 1198

Query: 223  QEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAES 282
            Q EL++L         + R  +ES   L   L D           R  Q Q  +M  A+S
Sbjct: 1199 QRELEQL-------GRQLRYYRESADPLGAWLQDA----------RRRQEQIQAMPLADS 1241

Query: 283  QTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQ 342
            Q               +R+QLR  +                LEE++ H +  EE QR  +
Sbjct: 1242 QA--------------VREQLRQEQAL--------------LEEIERHGEKVEECQRFAK 1273

Query: 343  RELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQL 402
            + +   ++  L+  T  +  +     ++   +Q   ++   E  +L     +L T   Q 
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 403  KVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQL---------QEELQCH 453
                S  +    E+E L   Q+   + +    E E  LE+Q+QL         Q E +  
Sbjct: 1334 IKFISETLRRMEEEERLAEQQR--AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391

Query: 454  EAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQ 513
            E + +   + V   + + +   +  +  +E++QL Q+S+ E++ +    +  E+  L  +
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451

Query: 514  LELKELKASHPIPE-DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQR 572
             E++ ++      E  +G    +   L +R  E + + + +Q+E  +L          +R
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL----------RR 1501

Query: 573  RMQEE-QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQN 631
            ++Q+E Q + Q E+   +    ++    + Q  L  LE+L  LQ       EE ++ ++ 
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQ------AEEAERRLRQ 1554

Query: 632  QDCVLKEQLEIH-EELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV 690
             +     Q+++  E  +R  E+  Q        SK A  ++     +  L  E +   Q+
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQ--------SKRASFAEKTAQLERSLQEEHVAVAQL 1606

Query: 691  MYDAGQAKQELLQQEQGRLLEERK------------RLQADLQLCLEEMQLLQVQSPSIK 738
              +A +  Q+  + E+ R   ER+            RL+   +   ++  L Q ++   K
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666

Query: 739  MSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE 798
               E   +  G         R+  +  ++      +     + +++  L    + T   E
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726

Query: 799  AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEE---PAEPEDMERFEEMVVK 855
               +        +   +++  +T      +        + E    ++    E       K
Sbjct: 1727 Q--QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1784

Query: 856  VLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915
               +L+A    ++   EE ++L+   E+   +Q+ L EE DA  R+  E    L + +A 
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEE-DAA-RQRAEAERVLAEKLAA 1841

Query: 916  QNDKNEIK-ELQTKLRELQLQYQ----ASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
              +   +K E +  L+E + + +     + DE  +   ++EQ        +E L QLR+ 
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901

Query: 971  RPSVVKEARG--KNANKNMNKNANGVKMKKVT--KPCSDTSESDLE----------TRKS 1016
              S ++  +G  ++  +   +    +   K +  K  +  +E +LE          T +S
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961

Query: 1017 LEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTE 1076
             E      A QR+   LA EEE++    EE+ Q    A+E+   +  A   + E  K+  
Sbjct: 1962 KEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018

Query: 1077 DQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
            ++     ++ E+E     +  ++ A   L++ E+ +   + + ++
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2063



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 172/853 (20%), Positives = 327/853 (38%), Gaps = 151/853 (17%)

Query: 301  QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS 360
            QQL  + EQ    +++CQ    EL+++            RLQ E  C    V R +    
Sbjct: 966  QQLLQSLEQGAQEESRCQRCISELKDI------------RLQLE-ACETRTVHRLRLPLD 1012

Query: 361  VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQ-LKVMKSTLVENQSEKELL 419
                 E   R+   QK    +Q E   L K   +L  E  + L + + +        EL 
Sbjct: 1013 KEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1068

Query: 420  CRLQKLHLQHQNVTCEKEKL------LERQQQLQEELQCHEAELQHLRDTVASFKESNEK 473
              L KL           EKL      +   Q  +E L+ HE +L+  +   A+  E    
Sbjct: 1069 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE---- 1124

Query: 474  DTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCA 533
                   L+  K   +  + + E Q+  +D L  +L   Q   + L+  H      G+  
Sbjct: 1125 -------LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH------GERD 1171

Query: 534  NKCDTLLSRLTELQEKYKA--SQKEMGQLQMEQC---------------ELLEDQRRMQE 576
             + +    R+ +L E+++A  +Q ++ Q ++EQ                  L+D RR QE
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231

Query: 577  EQGQLQEELHRLTLPLPKSGL----LLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQ 632
               Q+Q       +PL  S      L + Q LL ++E   E     Q   ++    I++ 
Sbjct: 1232 ---QIQ------AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282

Query: 633  DCVL---KEQLE-IHEELRRFK-ESHFQEVLENPDDSKLAKSSKCNRNKQ-SKLLMEQMQ 686
            +  L   K QLE +    ++ K +S  + V++   D +   S       Q  K + E ++
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342

Query: 687  ALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGK 746
             ++        ++E L ++Q    EER+RL A+++  LE+ + L       K   E   K
Sbjct: 1343 RME--------EEERLAEQQ--RAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAK 1391

Query: 747  SYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCT 806
                 +   E   +  +  VD            Q   +S  +       +SEA       
Sbjct: 1392 ELQQRM--QEEVVRREEAAVD-----------AQQQKRSIQEELQQLRQSSEA------- 1431

Query: 807  TSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAM 866
                                           E  A+    E  E   +++  +++ V+  
Sbjct: 1432 -------------------------------EIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460

Query: 867  YQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQ 926
             + ++ +    + +++ L A+     EE +A +R+ +E  E L + +  ++ +    E++
Sbjct: 1461 LEATERQRGGAEGELQALRAR----AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516

Query: 927  TKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
               R ++ + +A+ ++Q R L   E+L  Q +  +  LRQ   +R   V+ A      + 
Sbjct: 1517 LASR-VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVAL-----ET 1569

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETRKS-LEVVLYYKASQRKLDGLAKEEEKKEEMEE 1045
              ++A      K       T++ +   ++  + V    + ++R+    A+ E  +EE E 
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 1046 EKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSL 1105
            E ++ + +A E     L AE    +++ +  + E+ +E+ E E +     EE+      L
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689

Query: 1106 ESPEENNPLRLSE 1118
               E     +L+E
Sbjct: 1690 AEQELEKQRQLAE 1702



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 58/300 (19%), Positives = 122/300 (40%), Gaps = 26/300 (8%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            + ++ E  L  L  EE +  ++E+ ++E +   Q   S     + + R +   + +LE+L
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
                +    +L E ++   Q           +E ER       E   ++  + +  +R  
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQ----------MEQERQRLVASMEEARRRQHEAEEGVRRK 2569

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            +EE+  LE ++  + + + +E    + ++Q L +    +    E   AS       + N 
Sbjct: 2570 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2629

Query: 182  LEDMERIRGDYEME--IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLN-- 237
             + ++    + E E     LR ++  +  + +G L         EELQ L + +  ++  
Sbjct: 2630 RDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS-------AEELQRLAQGHTTVDEL 2682

Query: 238  ---EEYRALQESNSSLTGQLADLESER--TQRATERWLQSQTLSMTSAESQTSEMDFLEP 292
               E+ R   +  SS+ G L    +E+     A +R L S   ++   E+Q +    L+P
Sbjct: 2683 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2742


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  132 bits (331), Expect = 2e-30
 Identities = 258/1235 (20%), Positives = 489/1235 (39%), Gaps = 136/1235 (11%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            Q+ E E+   A   + E  E     +EEE   V+    +   +  + RG +  E EL+ L
Sbjct: 1431 QSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVR----LQLEATERQRGGA--EGELQAL 1482

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
            RA+     AE  E ++   Q E + L  Q   E +R    +QAEV  +   +++ E  + 
Sbjct: 1483 RAR-----AEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV--ELASRVKAEAEAA 1532

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            RE+   L+  +E  L+  E E  L QAE++  RQ      T   S  A LQ        +
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592

Query: 182  LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHF-LNEEY 240
               +ER   +  + +A LR E E ++ + +      +    +EE +   ER+    NE  
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQA------EAERAREEAERELERWQLKANEAL 1646

Query: 241  RA-LQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
            R  LQ    +    LA  E+E+ +   ER    +      AE Q      L  + E++  
Sbjct: 1647 RLRLQAEEVAQQKSLAQAEAEKQKEEAER----EARRRGKAEEQAVRQRELA-EQELEKQ 1701

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA--QNEVLRFQT 357
            RQ      +Q    + +   L  E E+ +  RQ+ EEE  RLQRE   A  + + L  + 
Sbjct: 1702 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1761

Query: 358  SHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE 417
            +    + E L +     +++  ++ ++  + L+ +     EL +       L E    + 
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821

Query: 418  LLCR--LQKLHLQHQNVTCEKEKLLERQQQLQEE----LQCHEAELQHLR----DTVASF 467
             L      +   + + V  EK   +    +L+ E    L+  EAE + LR    D     
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1881

Query: 468  KESNEKDTETHAQLQE-MKQLYQASKDELERQKHMYD-------QLEQDLLLCQLELKEL 519
            +   E+  +  A ++E + QL +AS  ELERQK + +       Q+E+++L  +   ++ 
Sbjct: 1882 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941

Query: 520  KASHPIPE-DKGKC-ANKCDTLLSR-----------------------LTELQEKYKASQ 554
             A     E + G+  +N  DTL S+                         E  +K  A++
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001

Query: 555  KEMGQLQMEQCELLEDQRRMQEEQGQL-----QEELHRLTLPLPKSGLLLKSQELLTKLE 609
            +E  + +    E +E  +   EE  +L     QE   +L L    +   L+++E      
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061

Query: 610  DLCELQLLYQGMQEEQKKL--IQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLA 667
               + Q L Q +Q+EQ  L  ++ +    +   E  EE R   E    +     ++++  
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121

Query: 668  KSS---KCNRNKQSKLLMEQM--QALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQL 722
            K S   +     Q++   E++  +A Q      QA+Q  L+Q+Q    E  K  +   Q 
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181

Query: 723  CLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTS 782
              ++ Q+ Q +  ++++ LE        +    +  +              +   S +  
Sbjct: 2182 LRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240

Query: 783  SKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAE 842
             +   K      +  EA  ++       +        +       +++   S   +E A 
Sbjct: 2241 MEELSKL----KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296

Query: 843  -----PEDMERFEEMVVKVLI-KLQAVQ------AMYQISQEEHSQLQEQMEKLLAKQKD 890
                  ED+ +   +  K+L  K+QAVQ      A  ++ Q++    QEQ  +L   ++ 
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356

Query: 891  LKEELDACEREFKECMEC-----LEKPMAPQNDKNEIKEL---QTKLRELQLQYQASMDE 942
            + ++L    + F+  +E      LE     +  K  + E+   Q +  E   +++   +E
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2416

Query: 943  QGRLL-----------VVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNM---- 987
             G  L            + + LE Q Q    +  +LRE    + +E         +    
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476

Query: 988  NKNANGVKMKKVTKPCSDTSESDLETRKSL-EVVLYYKASQRKLDGLAKEEEKKEEMEEE 1046
            ++    V+ +++ +      +S L  + SL +   + +  + KL+ L ++E  K +   E
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536

Query: 1047 KKQVKEEAKEQCGDELVA-------EPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEED 1099
            ++Q +++  EQ    LVA          + EE    + +E  + +++  ++EE   EE  
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2596

Query: 1100 DADSSLESPEENNPLRLSESKKSSPTPNPPIFSLP 1134
                 L+  EE +   L+ S++ + +      +LP
Sbjct: 2597 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2631



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 218/1125 (19%), Positives = 442/1125 (39%), Gaps = 149/1125 (13%)

Query: 55   ETELEELRAQVLQLVAELEETREL-----AGQHEDDSLELQ-GLLEDERLASAQQAEVFT 108
            + E+E L   V +L AE E+   L     A       LEL  G LE  R  SA    ++ 
Sbjct: 1034 QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA----IYL 1089

Query: 109  KQIQQLQGELRSLREEISLLEHEKESELKEIEQ------ELHLAQAEIQSLRQAAEDSAT 162
            ++++ +   +R  +    +L   +E +LKE +       EL   +A ++ LR  AE    
Sbjct: 1090 EKLKTISLVIRGTQGAEEVLRAHEE-QLKEAQAVPATLPELEATKASLKKLRAQAE---- 1144

Query: 163  EHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGL 222
              +    +L+++L   Q   E +++  G+ ++E+   R  +          L  +D    
Sbjct: 1145 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-- 1202

Query: 223  QEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAES 282
            Q EL++L         + R  +ES   L   L D           R  Q Q  +M  A+S
Sbjct: 1203 QRELEQL-------GRQLRYYRESADPLGAWLQDA----------RRRQEQIQAMPLADS 1245

Query: 283  QTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQ 342
            Q               +R+QLR  +                LEE++ H +  EE QR  +
Sbjct: 1246 QA--------------VREQLRQEQAL--------------LEEIERHGEKVEECQRFAK 1277

Query: 343  RELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQL 402
            + +   ++  L+  T  +  +     ++   +Q   ++   E  +L     +L T   Q 
Sbjct: 1278 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1337

Query: 403  KVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQL---------QEELQCH 453
                S  +    E+E L   Q+   + +    E E  LE+Q+QL         Q E +  
Sbjct: 1338 IKFISETLRRMEEEERLAEQQR--AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1395

Query: 454  EAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQ 513
            E + +   + V   + + +   +  +  +E++QL Q+S+ E++ +    +  E+  L  +
Sbjct: 1396 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1455

Query: 514  LELKELKASHPIPE-DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQR 572
             E++ ++      E  +G    +   L +R  E + + + +Q+E  +L          +R
Sbjct: 1456 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL----------RR 1505

Query: 573  RMQEE-QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQN 631
            ++Q+E Q + Q E+   +    ++    + Q  L  LE+L  LQ       EE ++ ++ 
Sbjct: 1506 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQ------AEEAERRLRQ 1558

Query: 632  QDCVLKEQLEIH-EELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV 690
             +     Q+++  E  +R  E+  Q        SK A  ++     +  L  E +   Q+
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQ--------SKRASFAEKTAQLERSLQEEHVAVAQL 1610

Query: 691  MYDAGQAKQELLQQEQGRLLEERK------------RLQADLQLCLEEMQLLQVQSPSIK 738
              +A +  Q+  + E+ R   ER+            RL+   +   ++  L Q ++   K
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670

Query: 739  MSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE 798
               E   +  G         R+  +  ++      +     + +++  L    + T   E
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730

Query: 799  AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEE---PAEPEDMERFEEMVVK 855
               +        +   +++  +T      +        + E    ++    E       K
Sbjct: 1731 Q--QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1788

Query: 856  VLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915
               +L+A    ++   EE ++L+   E+   +Q+ L EE DA  R+  E    L + +A 
Sbjct: 1789 SKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEE-DAA-RQRAEAERVLAEKLAA 1845

Query: 916  QNDKNEIK-ELQTKLRELQLQYQ----ASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
              +   +K E +  L+E + + +     + DE  +   ++EQ        +E L QLR+ 
Sbjct: 1846 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905

Query: 971  RPSVVKEARG--KNANKNMNKNANGVKMKKVT--KPCSDTSESDLE----------TRKS 1016
              S ++  +G  ++  +   +    +   K +  K  +  +E +LE          T +S
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965

Query: 1017 LEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTE 1076
             E      A QR+   LA EEE++    EE+ Q    A+E+   +  A   + E  K+  
Sbjct: 1966 KEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2022

Query: 1077 DQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
            ++     ++ E+E     +  ++ A   L++ E+ +   + + ++
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2067



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 172/853 (20%), Positives = 327/853 (38%), Gaps = 151/853 (17%)

Query: 301  QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS 360
            QQL  + EQ    +++CQ    EL+++            RLQ E  C    V R +    
Sbjct: 970  QQLLQSLEQGAQEESRCQRCISELKDI------------RLQLE-ACETRTVHRLRLPLD 1016

Query: 361  VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQ-LKVMKSTLVENQSEKELL 419
                 E   R+   QK    +Q E   L K   +L  E  + L + + +        EL 
Sbjct: 1017 KEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1072

Query: 420  CRLQKLHLQHQNVTCEKEKL------LERQQQLQEELQCHEAELQHLRDTVASFKESNEK 473
              L KL           EKL      +   Q  +E L+ HE +L+  +   A+  E    
Sbjct: 1073 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE---- 1128

Query: 474  DTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCA 533
                   L+  K   +  + + E Q+  +D L  +L   Q   + L+  H      G+  
Sbjct: 1129 -------LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH------GERD 1175

Query: 534  NKCDTLLSRLTELQEKYKA--SQKEMGQLQMEQC---------------ELLEDQRRMQE 576
             + +    R+ +L E+++A  +Q ++ Q ++EQ                  L+D RR QE
Sbjct: 1176 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1235

Query: 577  EQGQLQEELHRLTLPLPKSGL----LLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQ 632
               Q+Q       +PL  S      L + Q LL ++E   E     Q   ++    I++ 
Sbjct: 1236 ---QIQ------AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286

Query: 633  DCVL---KEQLE-IHEELRRFK-ESHFQEVLENPDDSKLAKSSKCNRNKQ-SKLLMEQMQ 686
            +  L   K QLE +    ++ K +S  + V++   D +   S       Q  K + E ++
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346

Query: 687  ALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGK 746
             ++        ++E L ++Q    EER+RL A+++  LE+ + L       K   E   K
Sbjct: 1347 RME--------EEERLAEQQ--RAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAK 1395

Query: 747  SYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCT 806
                 +   E   +  +  VD            Q   +S  +       +SEA       
Sbjct: 1396 ELQQRM--QEEVVRREEAAVD-----------AQQQKRSIQEELQQLRQSSEA------- 1435

Query: 807  TSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAM 866
                                           E  A+    E  E   +++  +++ V+  
Sbjct: 1436 -------------------------------EIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464

Query: 867  YQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQ 926
             + ++ +    + +++ L A+     EE +A +R+ +E  E L + +  ++ +    E++
Sbjct: 1465 LEATERQRGGAEGELQALRAR----AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1520

Query: 927  TKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
               R ++ + +A+ ++Q R L   E+L  Q +  +  LRQ   +R   V+ A      + 
Sbjct: 1521 LASR-VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVAL-----ET 1573

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETRKS-LEVVLYYKASQRKLDGLAKEEEKKEEMEE 1045
              ++A      K       T++ +   ++  + V    + ++R+    A+ E  +EE E 
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633

Query: 1046 EKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSL 1105
            E ++ + +A E     L AE    +++ +  + E+ +E+ E E +     EE+      L
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1693

Query: 1106 ESPEENNPLRLSE 1118
               E     +L+E
Sbjct: 1694 AEQELEKQRQLAE 1706



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 58/300 (19%), Positives = 122/300 (40%), Gaps = 26/300 (8%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            + ++ E  L  L  EE +  ++E+ ++E +   Q   S     + + R +   + +LE+L
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2523

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
                +    +L E ++   Q           +E ER       E   ++  + +  +R  
Sbjct: 2524 FQDEVAKAQQLREEQQRQQQQ----------MEQERQRLVASMEEARRRQHEAEEGVRRK 2573

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            +EE+  LE ++  + + + +E    + ++Q L +    +    E   AS       + N 
Sbjct: 2574 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2633

Query: 182  LEDMERIRGDYEME--IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLN-- 237
             + ++    + E E     LR ++  +  + +G L         EELQ L + +  ++  
Sbjct: 2634 RDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS-------AEELQRLAQGHTTVDEL 2686

Query: 238  ---EEYRALQESNSSLTGQLADLESER--TQRATERWLQSQTLSMTSAESQTSEMDFLEP 292
               E+ R   +  SS+ G L    +E+     A +R L S   ++   E+Q +    L+P
Sbjct: 2687 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2746


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  132 bits (331), Expect = 2e-30
 Identities = 258/1235 (20%), Positives = 489/1235 (39%), Gaps = 136/1235 (11%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            Q+ E E+   A   + E  E     +EEE   V+    +   +  + RG +  E EL+ L
Sbjct: 1427 QSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVR----LQLEATERQRGGA--EGELQAL 1478

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
            RA+     AE  E ++   Q E + L  Q   E +R    +QAEV  +   +++ E  + 
Sbjct: 1479 RAR-----AEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV--ELASRVKAEAEAA 1528

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            RE+   L+  +E  L+  E E  L QAE++  RQ      T   S  A LQ        +
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 182  LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHF-LNEEY 240
               +ER   +  + +A LR E E ++ + +      +    +EE +   ER+    NE  
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQA------EAERAREEAERELERWQLKANEAL 1642

Query: 241  RA-LQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
            R  LQ    +    LA  E+E+ +   ER    +      AE Q      L  + E++  
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKEEAER----EARRRGKAEEQAVRQRELA-EQELEKQ 1697

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA--QNEVLRFQT 357
            RQ      +Q    + +   L  E E+ +  RQ+ EEE  RLQRE   A  + + L  + 
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757

Query: 358  SHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE 417
            +    + E L +     +++  ++ ++  + L+ +     EL +       L E    + 
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817

Query: 418  LLCR--LQKLHLQHQNVTCEKEKLLERQQQLQEE----LQCHEAELQHLR----DTVASF 467
             L      +   + + V  EK   +    +L+ E    L+  EAE + LR    D     
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1877

Query: 468  KESNEKDTETHAQLQE-MKQLYQASKDELERQKHMYD-------QLEQDLLLCQLELKEL 519
            +   E+  +  A ++E + QL +AS  ELERQK + +       Q+E+++L  +   ++ 
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 520  KASHPIPE-DKGKC-ANKCDTLLSR-----------------------LTELQEKYKASQ 554
             A     E + G+  +N  DTL S+                         E  +K  A++
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997

Query: 555  KEMGQLQMEQCELLEDQRRMQEEQGQL-----QEELHRLTLPLPKSGLLLKSQELLTKLE 609
            +E  + +    E +E  +   EE  +L     QE   +L L    +   L+++E      
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057

Query: 610  DLCELQLLYQGMQEEQKKL--IQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLA 667
               + Q L Q +Q+EQ  L  ++ +    +   E  EE R   E    +     ++++  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117

Query: 668  KSS---KCNRNKQSKLLMEQM--QALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQL 722
            K S   +     Q++   E++  +A Q      QA+Q  L+Q+Q    E  K  +   Q 
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177

Query: 723  CLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTS 782
              ++ Q+ Q +  ++++ LE        +    +  +              +   S +  
Sbjct: 2178 LRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236

Query: 783  SKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAE 842
             +   K      +  EA  ++       +        +       +++   S   +E A 
Sbjct: 2237 MEELSKL----KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292

Query: 843  -----PEDMERFEEMVVKVLI-KLQAVQ------AMYQISQEEHSQLQEQMEKLLAKQKD 890
                  ED+ +   +  K+L  K+QAVQ      A  ++ Q++    QEQ  +L   ++ 
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352

Query: 891  LKEELDACEREFKECMEC-----LEKPMAPQNDKNEIKEL---QTKLRELQLQYQASMDE 942
            + ++L    + F+  +E      LE     +  K  + E+   Q +  E   +++   +E
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412

Query: 943  QGRLL-----------VVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNM---- 987
             G  L            + + LE Q Q    +  +LRE    + +E         +    
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472

Query: 988  NKNANGVKMKKVTKPCSDTSESDLETRKSL-EVVLYYKASQRKLDGLAKEEEKKEEMEEE 1046
            ++    V+ +++ +      +S L  + SL +   + +  + KL+ L ++E  K +   E
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532

Query: 1047 KKQVKEEAKEQCGDELVA-------EPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEED 1099
            ++Q +++  EQ    LVA          + EE    + +E  + +++  ++EE   EE  
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592

Query: 1100 DADSSLESPEENNPLRLSESKKSSPTPNPPIFSLP 1134
                 L+  EE +   L+ S++ + +      +LP
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 218/1125 (19%), Positives = 442/1125 (39%), Gaps = 149/1125 (13%)

Query: 55   ETELEELRAQVLQLVAELEETREL-----AGQHEDDSLELQ-GLLEDERLASAQQAEVFT 108
            + E+E L   V +L AE E+   L     A       LEL  G LE  R  SA    ++ 
Sbjct: 1030 QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA----IYL 1085

Query: 109  KQIQQLQGELRSLREEISLLEHEKESELKEIEQ------ELHLAQAEIQSLRQAAEDSAT 162
            ++++ +   +R  +    +L   +E +LKE +       EL   +A ++ LR  AE    
Sbjct: 1086 EKLKTISLVIRGTQGAEEVLRAHEE-QLKEAQAVPATLPELEATKASLKKLRAQAE---- 1140

Query: 163  EHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGL 222
              +    +L+++L   Q   E +++  G+ ++E+   R  +          L  +D    
Sbjct: 1141 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-- 1198

Query: 223  QEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAES 282
            Q EL++L         + R  +ES   L   L D           R  Q Q  +M  A+S
Sbjct: 1199 QRELEQL-------GRQLRYYRESADPLGAWLQDA----------RRRQEQIQAMPLADS 1241

Query: 283  QTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQ 342
            Q               +R+QLR  +                LEE++ H +  EE QR  +
Sbjct: 1242 QA--------------VREQLRQEQAL--------------LEEIERHGEKVEECQRFAK 1273

Query: 343  RELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQL 402
            + +   ++  L+  T  +  +     ++   +Q   ++   E  +L     +L T   Q 
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 403  KVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQL---------QEELQCH 453
                S  +    E+E L   Q+   + +    E E  LE+Q+QL         Q E +  
Sbjct: 1334 IKFISETLRRMEEEERLAEQQR--AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391

Query: 454  EAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQ 513
            E + +   + V   + + +   +  +  +E++QL Q+S+ E++ +    +  E+  L  +
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451

Query: 514  LELKELKASHPIPE-DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQR 572
             E++ ++      E  +G    +   L +R  E + + + +Q+E  +L          +R
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL----------RR 1501

Query: 573  RMQEE-QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQN 631
            ++Q+E Q + Q E+   +    ++    + Q  L  LE+L  LQ       EE ++ ++ 
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQ------AEEAERRLRQ 1554

Query: 632  QDCVLKEQLEIH-EELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV 690
             +     Q+++  E  +R  E+  Q        SK A  ++     +  L  E +   Q+
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQ--------SKRASFAEKTAQLERSLQEEHVAVAQL 1606

Query: 691  MYDAGQAKQELLQQEQGRLLEERK------------RLQADLQLCLEEMQLLQVQSPSIK 738
              +A +  Q+  + E+ R   ER+            RL+   +   ++  L Q ++   K
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666

Query: 739  MSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE 798
               E   +  G         R+  +  ++      +     + +++  L    + T   E
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726

Query: 799  AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEE---PAEPEDMERFEEMVVK 855
               +        +   +++  +T      +        + E    ++    E       K
Sbjct: 1727 Q--QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1784

Query: 856  VLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915
               +L+A    ++   EE ++L+   E+   +Q+ L EE DA  R+  E    L + +A 
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEE-DAA-RQRAEAERVLAEKLAA 1841

Query: 916  QNDKNEIK-ELQTKLRELQLQYQ----ASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
              +   +K E +  L+E + + +     + DE  +   ++EQ        +E L QLR+ 
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901

Query: 971  RPSVVKEARG--KNANKNMNKNANGVKMKKVT--KPCSDTSESDLE----------TRKS 1016
              S ++  +G  ++  +   +    +   K +  K  +  +E +LE          T +S
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961

Query: 1017 LEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTE 1076
             E      A QR+   LA EEE++    EE+ Q    A+E+   +  A   + E  K+  
Sbjct: 1962 KEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018

Query: 1077 DQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
            ++     ++ E+E     +  ++ A   L++ E+ +   + + ++
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2063



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 172/853 (20%), Positives = 327/853 (38%), Gaps = 151/853 (17%)

Query: 301  QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS 360
            QQL  + EQ    +++CQ    EL+++            RLQ E  C    V R +    
Sbjct: 966  QQLLQSLEQGAQEESRCQRCISELKDI------------RLQLE-ACETRTVHRLRLPLD 1012

Query: 361  VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQ-LKVMKSTLVENQSEKELL 419
                 E   R+   QK    +Q E   L K   +L  E  + L + + +        EL 
Sbjct: 1013 KEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1068

Query: 420  CRLQKLHLQHQNVTCEKEKL------LERQQQLQEELQCHEAELQHLRDTVASFKESNEK 473
              L KL           EKL      +   Q  +E L+ HE +L+  +   A+  E    
Sbjct: 1069 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE---- 1124

Query: 474  DTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCA 533
                   L+  K   +  + + E Q+  +D L  +L   Q   + L+  H      G+  
Sbjct: 1125 -------LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH------GERD 1171

Query: 534  NKCDTLLSRLTELQEKYKA--SQKEMGQLQMEQC---------------ELLEDQRRMQE 576
             + +    R+ +L E+++A  +Q ++ Q ++EQ                  L+D RR QE
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231

Query: 577  EQGQLQEELHRLTLPLPKSGL----LLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQ 632
               Q+Q       +PL  S      L + Q LL ++E   E     Q   ++    I++ 
Sbjct: 1232 ---QIQ------AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282

Query: 633  DCVL---KEQLE-IHEELRRFK-ESHFQEVLENPDDSKLAKSSKCNRNKQ-SKLLMEQMQ 686
            +  L   K QLE +    ++ K +S  + V++   D +   S       Q  K + E ++
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342

Query: 687  ALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGK 746
             ++        ++E L ++Q    EER+RL A+++  LE+ + L       K   E   K
Sbjct: 1343 RME--------EEERLAEQQ--RAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAK 1391

Query: 747  SYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCT 806
                 +   E   +  +  VD            Q   +S  +       +SEA       
Sbjct: 1392 ELQQRM--QEEVVRREEAAVD-----------AQQQKRSIQEELQQLRQSSEA------- 1431

Query: 807  TSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAM 866
                                           E  A+    E  E   +++  +++ V+  
Sbjct: 1432 -------------------------------EIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460

Query: 867  YQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQ 926
             + ++ +    + +++ L A+     EE +A +R+ +E  E L + +  ++ +    E++
Sbjct: 1461 LEATERQRGGAEGELQALRAR----AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516

Query: 927  TKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
               R ++ + +A+ ++Q R L   E+L  Q +  +  LRQ   +R   V+ A      + 
Sbjct: 1517 LASR-VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVAL-----ET 1569

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETRKS-LEVVLYYKASQRKLDGLAKEEEKKEEMEE 1045
              ++A      K       T++ +   ++  + V    + ++R+    A+ E  +EE E 
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 1046 EKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSL 1105
            E ++ + +A E     L AE    +++ +  + E+ +E+ E E +     EE+      L
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689

Query: 1106 ESPEENNPLRLSE 1118
               E     +L+E
Sbjct: 1690 AEQELEKQRQLAE 1702



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 58/300 (19%), Positives = 122/300 (40%), Gaps = 26/300 (8%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            + ++ E  L  L  EE +  ++E+ ++E +   Q   S     + + R +   + +LE+L
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
                +    +L E ++   Q           +E ER       E   ++  + +  +R  
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQ----------MEQERQRLVASMEEARRRQHEAEEGVRRK 2569

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            +EE+  LE ++  + + + +E    + ++Q L +    +    E   AS       + N 
Sbjct: 2570 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2629

Query: 182  LEDMERIRGDYEME--IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLN-- 237
             + ++    + E E     LR ++  +  + +G L         EELQ L + +  ++  
Sbjct: 2630 RDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS-------AEELQRLAQGHTTVDEL 2682

Query: 238  ---EEYRALQESNSSLTGQLADLESER--TQRATERWLQSQTLSMTSAESQTSEMDFLEP 292
               E+ R   +  SS+ G L    +E+     A +R L S   ++   E+Q +    L+P
Sbjct: 2683 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2742


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  132 bits (331), Expect = 2e-30
 Identities = 258/1235 (20%), Positives = 489/1235 (39%), Gaps = 136/1235 (11%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            Q+ E E+   A   + E  E     +EEE   V+    +   +  + RG +  E EL+ L
Sbjct: 1395 QSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVR----LQLEATERQRGGA--EGELQAL 1446

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
            RA+     AE  E ++   Q E + L  Q   E +R    +QAEV  +   +++ E  + 
Sbjct: 1447 RAR-----AEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV--ELASRVKAEAEAA 1496

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            RE+   L+  +E  L+  E E  L QAE++  RQ      T   S  A LQ        +
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556

Query: 182  LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHF-LNEEY 240
               +ER   +  + +A LR E E ++ + +      +    +EE +   ER+    NE  
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQA------EAERAREEAERELERWQLKANEAL 1610

Query: 241  RA-LQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
            R  LQ    +    LA  E+E+ +   ER    +      AE Q      L  + E++  
Sbjct: 1611 RLRLQAEEVAQQKSLAQAEAEKQKEEAER----EARRRGKAEEQAVRQRELA-EQELEKQ 1665

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA--QNEVLRFQT 357
            RQ      +Q    + +   L  E E+ +  RQ+ EEE  RLQRE   A  + + L  + 
Sbjct: 1666 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1725

Query: 358  SHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE 417
            +    + E L +     +++  ++ ++  + L+ +     EL +       L E    + 
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785

Query: 418  LLCR--LQKLHLQHQNVTCEKEKLLERQQQLQEE----LQCHEAELQHLR----DTVASF 467
             L      +   + + V  EK   +    +L+ E    L+  EAE + LR    D     
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1845

Query: 468  KESNEKDTETHAQLQE-MKQLYQASKDELERQKHMYD-------QLEQDLLLCQLELKEL 519
            +   E+  +  A ++E + QL +AS  ELERQK + +       Q+E+++L  +   ++ 
Sbjct: 1846 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905

Query: 520  KASHPIPE-DKGKC-ANKCDTLLSR-----------------------LTELQEKYKASQ 554
             A     E + G+  +N  DTL S+                         E  +K  A++
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965

Query: 555  KEMGQLQMEQCELLEDQRRMQEEQGQL-----QEELHRLTLPLPKSGLLLKSQELLTKLE 609
            +E  + +    E +E  +   EE  +L     QE   +L L    +   L+++E      
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025

Query: 610  DLCELQLLYQGMQEEQKKL--IQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLA 667
               + Q L Q +Q+EQ  L  ++ +    +   E  EE R   E    +     ++++  
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2085

Query: 668  KSS---KCNRNKQSKLLMEQM--QALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQL 722
            K S   +     Q++   E++  +A Q      QA+Q  L+Q+Q    E  K  +   Q 
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145

Query: 723  CLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTS 782
              ++ Q+ Q +  ++++ LE        +    +  +              +   S +  
Sbjct: 2146 LRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204

Query: 783  SKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAE 842
             +   K      +  EA  ++       +        +       +++   S   +E A 
Sbjct: 2205 MEELSKL----KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2260

Query: 843  -----PEDMERFEEMVVKVLI-KLQAVQ------AMYQISQEEHSQLQEQMEKLLAKQKD 890
                  ED+ +   +  K+L  K+QAVQ      A  ++ Q++    QEQ  +L   ++ 
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320

Query: 891  LKEELDACEREFKECMEC-----LEKPMAPQNDKNEIKEL---QTKLRELQLQYQASMDE 942
            + ++L    + F+  +E      LE     +  K  + E+   Q +  E   +++   +E
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2380

Query: 943  QGRLL-----------VVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNM---- 987
             G  L            + + LE Q Q    +  +LRE    + +E         +    
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440

Query: 988  NKNANGVKMKKVTKPCSDTSESDLETRKSL-EVVLYYKASQRKLDGLAKEEEKKEEMEEE 1046
            ++    V+ +++ +      +S L  + SL +   + +  + KL+ L ++E  K +   E
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500

Query: 1047 KKQVKEEAKEQCGDELVA-------EPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEED 1099
            ++Q +++  EQ    LVA          + EE    + +E  + +++  ++EE   EE  
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2560

Query: 1100 DADSSLESPEENNPLRLSESKKSSPTPNPPIFSLP 1134
                 L+  EE +   L+ S++ + +      +LP
Sbjct: 2561 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2595



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 218/1125 (19%), Positives = 442/1125 (39%), Gaps = 149/1125 (13%)

Query: 55   ETELEELRAQVLQLVAELEETREL-----AGQHEDDSLELQ-GLLEDERLASAQQAEVFT 108
            + E+E L   V +L AE E+   L     A       LEL  G LE  R  SA    ++ 
Sbjct: 998  QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA----IYL 1053

Query: 109  KQIQQLQGELRSLREEISLLEHEKESELKEIEQ------ELHLAQAEIQSLRQAAEDSAT 162
            ++++ +   +R  +    +L   +E +LKE +       EL   +A ++ LR  AE    
Sbjct: 1054 EKLKTISLVIRGTQGAEEVLRAHEE-QLKEAQAVPATLPELEATKASLKKLRAQAE---- 1108

Query: 163  EHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGL 222
              +    +L+++L   Q   E +++  G+ ++E+   R  +          L  +D    
Sbjct: 1109 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-- 1166

Query: 223  QEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAES 282
            Q EL++L         + R  +ES   L   L D           R  Q Q  +M  A+S
Sbjct: 1167 QRELEQL-------GRQLRYYRESADPLGAWLQDA----------RRRQEQIQAMPLADS 1209

Query: 283  QTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQ 342
            Q               +R+QLR  +                LEE++ H +  EE QR  +
Sbjct: 1210 QA--------------VREQLRQEQAL--------------LEEIERHGEKVEECQRFAK 1241

Query: 343  RELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQL 402
            + +   ++  L+  T  +  +     ++   +Q   ++   E  +L     +L T   Q 
Sbjct: 1242 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1301

Query: 403  KVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQL---------QEELQCH 453
                S  +    E+E L   Q+   + +    E E  LE+Q+QL         Q E +  
Sbjct: 1302 IKFISETLRRMEEEERLAEQQR--AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1359

Query: 454  EAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQ 513
            E + +   + V   + + +   +  +  +E++QL Q+S+ E++ +    +  E+  L  +
Sbjct: 1360 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1419

Query: 514  LELKELKASHPIPE-DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQR 572
             E++ ++      E  +G    +   L +R  E + + + +Q+E  +L          +R
Sbjct: 1420 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL----------RR 1469

Query: 573  RMQEE-QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQN 631
            ++Q+E Q + Q E+   +    ++    + Q  L  LE+L  LQ       EE ++ ++ 
Sbjct: 1470 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQ------AEEAERRLRQ 1522

Query: 632  QDCVLKEQLEIH-EELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV 690
             +     Q+++  E  +R  E+  Q        SK A  ++     +  L  E +   Q+
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQ--------SKRASFAEKTAQLERSLQEEHVAVAQL 1574

Query: 691  MYDAGQAKQELLQQEQGRLLEERK------------RLQADLQLCLEEMQLLQVQSPSIK 738
              +A +  Q+  + E+ R   ER+            RL+   +   ++  L Q ++   K
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634

Query: 739  MSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE 798
               E   +  G         R+  +  ++      +     + +++  L    + T   E
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694

Query: 799  AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEE---PAEPEDMERFEEMVVK 855
               +        +   +++  +T      +        + E    ++    E       K
Sbjct: 1695 Q--QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1752

Query: 856  VLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915
               +L+A    ++   EE ++L+   E+   +Q+ L EE DA  R+  E    L + +A 
Sbjct: 1753 SKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEE-DAA-RQRAEAERVLAEKLAA 1809

Query: 916  QNDKNEIK-ELQTKLRELQLQYQ----ASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
              +   +K E +  L+E + + +     + DE  +   ++EQ        +E L QLR+ 
Sbjct: 1810 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1869

Query: 971  RPSVVKEARG--KNANKNMNKNANGVKMKKVT--KPCSDTSESDLE----------TRKS 1016
              S ++  +G  ++  +   +    +   K +  K  +  +E +LE          T +S
Sbjct: 1870 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929

Query: 1017 LEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTE 1076
             E      A QR+   LA EEE++    EE+ Q    A+E+   +  A   + E  K+  
Sbjct: 1930 KEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1986

Query: 1077 DQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
            ++     ++ E+E     +  ++ A   L++ E+ +   + + ++
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2031



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 172/853 (20%), Positives = 327/853 (38%), Gaps = 151/853 (17%)

Query: 301  QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS 360
            QQL  + EQ    +++CQ    EL+++            RLQ E  C    V R +    
Sbjct: 934  QQLLQSLEQGAQEESRCQRCISELKDI------------RLQLE-ACETRTVHRLRLPLD 980

Query: 361  VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQ-LKVMKSTLVENQSEKELL 419
                 E   R+   QK    +Q E   L K   +L  E  + L + + +        EL 
Sbjct: 981  KEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1036

Query: 420  CRLQKLHLQHQNVTCEKEKL------LERQQQLQEELQCHEAELQHLRDTVASFKESNEK 473
              L KL           EKL      +   Q  +E L+ HE +L+  +   A+  E    
Sbjct: 1037 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE---- 1092

Query: 474  DTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCA 533
                   L+  K   +  + + E Q+  +D L  +L   Q   + L+  H      G+  
Sbjct: 1093 -------LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH------GERD 1139

Query: 534  NKCDTLLSRLTELQEKYKA--SQKEMGQLQMEQC---------------ELLEDQRRMQE 576
             + +    R+ +L E+++A  +Q ++ Q ++EQ                  L+D RR QE
Sbjct: 1140 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1199

Query: 577  EQGQLQEELHRLTLPLPKSGL----LLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQ 632
               Q+Q       +PL  S      L + Q LL ++E   E     Q   ++    I++ 
Sbjct: 1200 ---QIQ------AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250

Query: 633  DCVL---KEQLE-IHEELRRFK-ESHFQEVLENPDDSKLAKSSKCNRNKQ-SKLLMEQMQ 686
            +  L   K QLE +    ++ K +S  + V++   D +   S       Q  K + E ++
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1310

Query: 687  ALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGK 746
             ++        ++E L ++Q    EER+RL A+++  LE+ + L       K   E   K
Sbjct: 1311 RME--------EEERLAEQQ--RAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAK 1359

Query: 747  SYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCT 806
                 +   E   +  +  VD            Q   +S  +       +SEA       
Sbjct: 1360 ELQQRM--QEEVVRREEAAVD-----------AQQQKRSIQEELQQLRQSSEA------- 1399

Query: 807  TSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAM 866
                                           E  A+    E  E   +++  +++ V+  
Sbjct: 1400 -------------------------------EIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428

Query: 867  YQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQ 926
             + ++ +    + +++ L A+     EE +A +R+ +E  E L + +  ++ +    E++
Sbjct: 1429 LEATERQRGGAEGELQALRAR----AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1484

Query: 927  TKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
               R ++ + +A+ ++Q R L   E+L  Q +  +  LRQ   +R   V+ A      + 
Sbjct: 1485 LASR-VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVAL-----ET 1537

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETRKS-LEVVLYYKASQRKLDGLAKEEEKKEEMEE 1045
              ++A      K       T++ +   ++  + V    + ++R+    A+ E  +EE E 
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597

Query: 1046 EKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSL 1105
            E ++ + +A E     L AE    +++ +  + E+ +E+ E E +     EE+      L
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1657

Query: 1106 ESPEENNPLRLSE 1118
               E     +L+E
Sbjct: 1658 AEQELEKQRQLAE 1670



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 58/300 (19%), Positives = 122/300 (40%), Gaps = 26/300 (8%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            + ++ E  L  L  EE +  ++E+ ++E +   Q   S     + + R +   + +LE+L
Sbjct: 2428 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2487

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
                +    +L E ++   Q           +E ER       E   ++  + +  +R  
Sbjct: 2488 FQDEVAKAQQLREEQQRQQQQ----------MEQERQRLVASMEEARRRQHEAEEGVRRK 2537

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            +EE+  LE ++  + + + +E    + ++Q L +    +    E   AS       + N 
Sbjct: 2538 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2597

Query: 182  LEDMERIRGDYEME--IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLN-- 237
             + ++    + E E     LR ++  +  + +G L         EELQ L + +  ++  
Sbjct: 2598 RDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS-------AEELQRLAQGHTTVDEL 2650

Query: 238  ---EEYRALQESNSSLTGQLADLESER--TQRATERWLQSQTLSMTSAESQTSEMDFLEP 292
               E+ R   +  SS+ G L    +E+     A +R L S   ++   E+Q +    L+P
Sbjct: 2651 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2710


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  132 bits (331), Expect = 2e-30
 Identities = 258/1235 (20%), Positives = 489/1235 (39%), Gaps = 136/1235 (11%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            Q+ E E+   A   + E  E     +EEE   V+    +   +  + RG +  E EL+ L
Sbjct: 1564 QSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVR----LQLEATERQRGGA--EGELQAL 1615

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
            RA+     AE  E ++   Q E + L  Q   E +R    +QAEV  +   +++ E  + 
Sbjct: 1616 RAR-----AEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV--ELASRVKAEAEAA 1665

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            RE+   L+  +E  L+  E E  L QAE++  RQ      T   S  A LQ        +
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725

Query: 182  LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHF-LNEEY 240
               +ER   +  + +A LR E E ++ + +      +    +EE +   ER+    NE  
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQA------EAERAREEAERELERWQLKANEAL 1779

Query: 241  RA-LQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
            R  LQ    +    LA  E+E+ +   ER    +      AE Q      L  + E++  
Sbjct: 1780 RLRLQAEEVAQQKSLAQAEAEKQKEEAER----EARRRGKAEEQAVRQRELA-EQELEKQ 1834

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA--QNEVLRFQT 357
            RQ      +Q    + +   L  E E+ +  RQ+ EEE  RLQRE   A  + + L  + 
Sbjct: 1835 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1894

Query: 358  SHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE 417
            +    + E L +     +++  ++ ++  + L+ +     EL +       L E    + 
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954

Query: 418  LLCR--LQKLHLQHQNVTCEKEKLLERQQQLQEE----LQCHEAELQHLR----DTVASF 467
             L      +   + + V  EK   +    +L+ E    L+  EAE + LR    D     
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 2014

Query: 468  KESNEKDTETHAQLQE-MKQLYQASKDELERQKHMYD-------QLEQDLLLCQLELKEL 519
            +   E+  +  A ++E + QL +AS  ELERQK + +       Q+E+++L  +   ++ 
Sbjct: 2015 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074

Query: 520  KASHPIPE-DKGKC-ANKCDTLLSR-----------------------LTELQEKYKASQ 554
             A     E + G+  +N  DTL S+                         E  +K  A++
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134

Query: 555  KEMGQLQMEQCELLEDQRRMQEEQGQL-----QEELHRLTLPLPKSGLLLKSQELLTKLE 609
            +E  + +    E +E  +   EE  +L     QE   +L L    +   L+++E      
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194

Query: 610  DLCELQLLYQGMQEEQKKL--IQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLA 667
               + Q L Q +Q+EQ  L  ++ +    +   E  EE R   E    +     ++++  
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2254

Query: 668  KSS---KCNRNKQSKLLMEQM--QALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQL 722
            K S   +     Q++   E++  +A Q      QA+Q  L+Q+Q    E  K  +   Q 
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2314

Query: 723  CLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTS 782
              ++ Q+ Q +  ++++ LE        +    +  +              +   S +  
Sbjct: 2315 LRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373

Query: 783  SKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAE 842
             +   K      +  EA  ++       +        +       +++   S   +E A 
Sbjct: 2374 MEELSKL----KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2429

Query: 843  -----PEDMERFEEMVVKVLI-KLQAVQ------AMYQISQEEHSQLQEQMEKLLAKQKD 890
                  ED+ +   +  K+L  K+QAVQ      A  ++ Q++    QEQ  +L   ++ 
Sbjct: 2430 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489

Query: 891  LKEELDACEREFKECMEC-----LEKPMAPQNDKNEIKEL---QTKLRELQLQYQASMDE 942
            + ++L    + F+  +E      LE     +  K  + E+   Q +  E   +++   +E
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549

Query: 943  QGRLL-----------VVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNM---- 987
             G  L            + + LE Q Q    +  +LRE    + +E         +    
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609

Query: 988  NKNANGVKMKKVTKPCSDTSESDLETRKSL-EVVLYYKASQRKLDGLAKEEEKKEEMEEE 1046
            ++    V+ +++ +      +S L  + SL +   + +  + KL+ L ++E  K +   E
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669

Query: 1047 KKQVKEEAKEQCGDELVA-------EPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEED 1099
            ++Q +++  EQ    LVA          + EE    + +E  + +++  ++EE   EE  
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2729

Query: 1100 DADSSLESPEENNPLRLSESKKSSPTPNPPIFSLP 1134
                 L+  EE +   L+ S++ + +      +LP
Sbjct: 2730 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 218/1125 (19%), Positives = 442/1125 (39%), Gaps = 149/1125 (13%)

Query: 55   ETELEELRAQVLQLVAELEETREL-----AGQHEDDSLELQ-GLLEDERLASAQQAEVFT 108
            + E+E L   V +L AE E+   L     A       LEL  G LE  R  SA    ++ 
Sbjct: 1167 QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA----IYL 1222

Query: 109  KQIQQLQGELRSLREEISLLEHEKESELKEIEQ------ELHLAQAEIQSLRQAAEDSAT 162
            ++++ +   +R  +    +L   +E +LKE +       EL   +A ++ LR  AE    
Sbjct: 1223 EKLKTISLVIRGTQGAEEVLRAHEE-QLKEAQAVPATLPELEATKASLKKLRAQAE---- 1277

Query: 163  EHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGL 222
              +    +L+++L   Q   E +++  G+ ++E+   R  +          L  +D    
Sbjct: 1278 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-- 1335

Query: 223  QEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAES 282
            Q EL++L         + R  +ES   L   L D           R  Q Q  +M  A+S
Sbjct: 1336 QRELEQL-------GRQLRYYRESADPLGAWLQDA----------RRRQEQIQAMPLADS 1378

Query: 283  QTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQ 342
            Q               +R+QLR  +                LEE++ H +  EE QR  +
Sbjct: 1379 QA--------------VREQLRQEQAL--------------LEEIERHGEKVEECQRFAK 1410

Query: 343  RELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQL 402
            + +   ++  L+  T  +  +     ++   +Q   ++   E  +L     +L T   Q 
Sbjct: 1411 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470

Query: 403  KVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQL---------QEELQCH 453
                S  +    E+E L   Q+   + +    E E  LE+Q+QL         Q E +  
Sbjct: 1471 IKFISETLRRMEEEERLAEQQR--AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1528

Query: 454  EAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQ 513
            E + +   + V   + + +   +  +  +E++QL Q+S+ E++ +    +  E+  L  +
Sbjct: 1529 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588

Query: 514  LELKELKASHPIPE-DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQR 572
             E++ ++      E  +G    +   L +R  E + + + +Q+E  +L          +R
Sbjct: 1589 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL----------RR 1638

Query: 573  RMQEE-QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQN 631
            ++Q+E Q + Q E+   +    ++    + Q  L  LE+L  LQ       EE ++ ++ 
Sbjct: 1639 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQ------AEEAERRLRQ 1691

Query: 632  QDCVLKEQLEIH-EELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV 690
             +     Q+++  E  +R  E+  Q        SK A  ++     +  L  E +   Q+
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQ--------SKRASFAEKTAQLERSLQEEHVAVAQL 1743

Query: 691  MYDAGQAKQELLQQEQGRLLEERK------------RLQADLQLCLEEMQLLQVQSPSIK 738
              +A +  Q+  + E+ R   ER+            RL+   +   ++  L Q ++   K
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803

Query: 739  MSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE 798
               E   +  G         R+  +  ++      +     + +++  L    + T   E
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863

Query: 799  AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEE---PAEPEDMERFEEMVVK 855
               +        +   +++  +T      +        + E    ++    E       K
Sbjct: 1864 Q--QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1921

Query: 856  VLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915
               +L+A    ++   EE ++L+   E+   +Q+ L EE DA  R+  E    L + +A 
Sbjct: 1922 SKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEE-DAA-RQRAEAERVLAEKLAA 1978

Query: 916  QNDKNEIK-ELQTKLRELQLQYQ----ASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
              +   +K E +  L+E + + +     + DE  +   ++EQ        +E L QLR+ 
Sbjct: 1979 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038

Query: 971  RPSVVKEARG--KNANKNMNKNANGVKMKKVT--KPCSDTSESDLE----------TRKS 1016
              S ++  +G  ++  +   +    +   K +  K  +  +E +LE          T +S
Sbjct: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098

Query: 1017 LEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTE 1076
             E      A QR+   LA EEE++    EE+ Q    A+E+   +  A   + E  K+  
Sbjct: 2099 KEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155

Query: 1077 DQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
            ++     ++ E+E     +  ++ A   L++ E+ +   + + ++
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2200



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 172/853 (20%), Positives = 327/853 (38%), Gaps = 151/853 (17%)

Query: 301  QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS 360
            QQL  + EQ    +++CQ    EL+++            RLQ E  C    V R +    
Sbjct: 1103 QQLLQSLEQGAQEESRCQRCISELKDI------------RLQLE-ACETRTVHRLRLPLD 1149

Query: 361  VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQ-LKVMKSTLVENQSEKELL 419
                 E   R+   QK    +Q E   L K   +L  E  + L + + +        EL 
Sbjct: 1150 KEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1205

Query: 420  CRLQKLHLQHQNVTCEKEKL------LERQQQLQEELQCHEAELQHLRDTVASFKESNEK 473
              L KL           EKL      +   Q  +E L+ HE +L+  +   A+  E    
Sbjct: 1206 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE---- 1261

Query: 474  DTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCA 533
                   L+  K   +  + + E Q+  +D L  +L   Q   + L+  H      G+  
Sbjct: 1262 -------LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH------GERD 1308

Query: 534  NKCDTLLSRLTELQEKYKA--SQKEMGQLQMEQC---------------ELLEDQRRMQE 576
             + +    R+ +L E+++A  +Q ++ Q ++EQ                  L+D RR QE
Sbjct: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1368

Query: 577  EQGQLQEELHRLTLPLPKSGL----LLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQ 632
               Q+Q       +PL  S      L + Q LL ++E   E     Q   ++    I++ 
Sbjct: 1369 ---QIQ------AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419

Query: 633  DCVL---KEQLE-IHEELRRFK-ESHFQEVLENPDDSKLAKSSKCNRNKQ-SKLLMEQMQ 686
            +  L   K QLE +    ++ K +S  + V++   D +   S       Q  K + E ++
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1479

Query: 687  ALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGK 746
             ++        ++E L ++Q    EER+RL A+++  LE+ + L       K   E   K
Sbjct: 1480 RME--------EEERLAEQQ--RAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAK 1528

Query: 747  SYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCT 806
                 +   E   +  +  VD            Q   +S  +       +SEA       
Sbjct: 1529 ELQQRM--QEEVVRREEAAVD-----------AQQQKRSIQEELQQLRQSSEA------- 1568

Query: 807  TSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAM 866
                                           E  A+    E  E   +++  +++ V+  
Sbjct: 1569 -------------------------------EIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597

Query: 867  YQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQ 926
             + ++ +    + +++ L A+     EE +A +R+ +E  E L + +  ++ +    E++
Sbjct: 1598 LEATERQRGGAEGELQALRAR----AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1653

Query: 927  TKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
               R ++ + +A+ ++Q R L   E+L  Q +  +  LRQ   +R   V+ A      + 
Sbjct: 1654 LASR-VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVAL-----ET 1706

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETRKS-LEVVLYYKASQRKLDGLAKEEEKKEEMEE 1045
              ++A      K       T++ +   ++  + V    + ++R+    A+ E  +EE E 
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766

Query: 1046 EKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSL 1105
            E ++ + +A E     L AE    +++ +  + E+ +E+ E E +     EE+      L
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1826

Query: 1106 ESPEENNPLRLSE 1118
               E     +L+E
Sbjct: 1827 AEQELEKQRQLAE 1839



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 58/300 (19%), Positives = 122/300 (40%), Gaps = 26/300 (8%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            + ++ E  L  L  EE +  ++E+ ++E +   Q   S     + + R +   + +LE+L
Sbjct: 2597 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2656

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
                +    +L E ++   Q           +E ER       E   ++  + +  +R  
Sbjct: 2657 FQDEVAKAQQLREEQQRQQQQ----------MEQERQRLVASMEEARRRQHEAEEGVRRK 2706

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            +EE+  LE ++  + + + +E    + ++Q L +    +    E   AS       + N 
Sbjct: 2707 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2766

Query: 182  LEDMERIRGDYEME--IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLN-- 237
             + ++    + E E     LR ++  +  + +G L         EELQ L + +  ++  
Sbjct: 2767 RDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS-------AEELQRLAQGHTTVDEL 2819

Query: 238  ---EEYRALQESNSSLTGQLADLESER--TQRATERWLQSQTLSMTSAESQTSEMDFLEP 292
               E+ R   +  SS+ G L    +E+     A +R L S   ++   E+Q +    L+P
Sbjct: 2820 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2879


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  132 bits (331), Expect = 2e-30
 Identities = 258/1235 (20%), Positives = 489/1235 (39%), Gaps = 136/1235 (11%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            Q+ E E+   A   + E  E     +EEE   V+    +   +  + RG +  E EL+ L
Sbjct: 1405 QSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVR----LQLEATERQRGGA--EGELQAL 1456

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
            RA+     AE  E ++   Q E + L  Q   E +R    +QAEV  +   +++ E  + 
Sbjct: 1457 RAR-----AEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV--ELASRVKAEAEAA 1506

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            RE+   L+  +E  L+  E E  L QAE++  RQ      T   S  A LQ        +
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566

Query: 182  LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHF-LNEEY 240
               +ER   +  + +A LR E E ++ + +      +    +EE +   ER+    NE  
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQA------EAERAREEAERELERWQLKANEAL 1620

Query: 241  RA-LQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
            R  LQ    +    LA  E+E+ +   ER    +      AE Q      L  + E++  
Sbjct: 1621 RLRLQAEEVAQQKSLAQAEAEKQKEEAER----EARRRGKAEEQAVRQRELA-EQELEKQ 1675

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA--QNEVLRFQT 357
            RQ      +Q    + +   L  E E+ +  RQ+ EEE  RLQRE   A  + + L  + 
Sbjct: 1676 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1735

Query: 358  SHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE 417
            +    + E L +     +++  ++ ++  + L+ +     EL +       L E    + 
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795

Query: 418  LLCR--LQKLHLQHQNVTCEKEKLLERQQQLQEE----LQCHEAELQHLR----DTVASF 467
             L      +   + + V  EK   +    +L+ E    L+  EAE + LR    D     
Sbjct: 1796 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1855

Query: 468  KESNEKDTETHAQLQE-MKQLYQASKDELERQKHMYD-------QLEQDLLLCQLELKEL 519
            +   E+  +  A ++E + QL +AS  ELERQK + +       Q+E+++L  +   ++ 
Sbjct: 1856 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915

Query: 520  KASHPIPE-DKGKC-ANKCDTLLSR-----------------------LTELQEKYKASQ 554
             A     E + G+  +N  DTL S+                         E  +K  A++
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975

Query: 555  KEMGQLQMEQCELLEDQRRMQEEQGQL-----QEELHRLTLPLPKSGLLLKSQELLTKLE 609
            +E  + +    E +E  +   EE  +L     QE   +L L    +   L+++E      
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035

Query: 610  DLCELQLLYQGMQEEQKKL--IQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLA 667
               + Q L Q +Q+EQ  L  ++ +    +   E  EE R   E    +     ++++  
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2095

Query: 668  KSS---KCNRNKQSKLLMEQM--QALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQL 722
            K S   +     Q++   E++  +A Q      QA+Q  L+Q+Q    E  K  +   Q 
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2155

Query: 723  CLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTS 782
              ++ Q+ Q +  ++++ LE        +    +  +              +   S +  
Sbjct: 2156 LRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214

Query: 783  SKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAE 842
             +   K      +  EA  ++       +        +       +++   S   +E A 
Sbjct: 2215 MEELSKL----KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2270

Query: 843  -----PEDMERFEEMVVKVLI-KLQAVQ------AMYQISQEEHSQLQEQMEKLLAKQKD 890
                  ED+ +   +  K+L  K+QAVQ      A  ++ Q++    QEQ  +L   ++ 
Sbjct: 2271 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330

Query: 891  LKEELDACEREFKECMEC-----LEKPMAPQNDKNEIKEL---QTKLRELQLQYQASMDE 942
            + ++L    + F+  +E      LE     +  K  + E+   Q +  E   +++   +E
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390

Query: 943  QGRLL-----------VVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNM---- 987
             G  L            + + LE Q Q    +  +LRE    + +E         +    
Sbjct: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2450

Query: 988  NKNANGVKMKKVTKPCSDTSESDLETRKSL-EVVLYYKASQRKLDGLAKEEEKKEEMEEE 1046
            ++    V+ +++ +      +S L  + SL +   + +  + KL+ L ++E  K +   E
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510

Query: 1047 KKQVKEEAKEQCGDELVA-------EPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEED 1099
            ++Q +++  EQ    LVA          + EE    + +E  + +++  ++EE   EE  
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2570

Query: 1100 DADSSLESPEENNPLRLSESKKSSPTPNPPIFSLP 1134
                 L+  EE +   L+ S++ + +      +LP
Sbjct: 2571 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2605



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 218/1125 (19%), Positives = 442/1125 (39%), Gaps = 149/1125 (13%)

Query: 55   ETELEELRAQVLQLVAELEETREL-----AGQHEDDSLELQ-GLLEDERLASAQQAEVFT 108
            + E+E L   V +L AE E+   L     A       LEL  G LE  R  SA    ++ 
Sbjct: 1008 QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA----IYL 1063

Query: 109  KQIQQLQGELRSLREEISLLEHEKESELKEIEQ------ELHLAQAEIQSLRQAAEDSAT 162
            ++++ +   +R  +    +L   +E +LKE +       EL   +A ++ LR  AE    
Sbjct: 1064 EKLKTISLVIRGTQGAEEVLRAHEE-QLKEAQAVPATLPELEATKASLKKLRAQAE---- 1118

Query: 163  EHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGL 222
              +    +L+++L   Q   E +++  G+ ++E+   R  +          L  +D    
Sbjct: 1119 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-- 1176

Query: 223  QEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAES 282
            Q EL++L         + R  +ES   L   L D           R  Q Q  +M  A+S
Sbjct: 1177 QRELEQL-------GRQLRYYRESADPLGAWLQDA----------RRRQEQIQAMPLADS 1219

Query: 283  QTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQ 342
            Q               +R+QLR  +                LEE++ H +  EE QR  +
Sbjct: 1220 QA--------------VREQLRQEQAL--------------LEEIERHGEKVEECQRFAK 1251

Query: 343  RELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQL 402
            + +   ++  L+  T  +  +     ++   +Q   ++   E  +L     +L T   Q 
Sbjct: 1252 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311

Query: 403  KVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQL---------QEELQCH 453
                S  +    E+E L   Q+   + +    E E  LE+Q+QL         Q E +  
Sbjct: 1312 IKFISETLRRMEEEERLAEQQR--AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1369

Query: 454  EAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQ 513
            E + +   + V   + + +   +  +  +E++QL Q+S+ E++ +    +  E+  L  +
Sbjct: 1370 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429

Query: 514  LELKELKASHPIPE-DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQR 572
             E++ ++      E  +G    +   L +R  E + + + +Q+E  +L          +R
Sbjct: 1430 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL----------RR 1479

Query: 573  RMQEE-QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQN 631
            ++Q+E Q + Q E+   +    ++    + Q  L  LE+L  LQ       EE ++ ++ 
Sbjct: 1480 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQ------AEEAERRLRQ 1532

Query: 632  QDCVLKEQLEIH-EELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV 690
             +     Q+++  E  +R  E+  Q        SK A  ++     +  L  E +   Q+
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQ--------SKRASFAEKTAQLERSLQEEHVAVAQL 1584

Query: 691  MYDAGQAKQELLQQEQGRLLEERK------------RLQADLQLCLEEMQLLQVQSPSIK 738
              +A +  Q+  + E+ R   ER+            RL+   +   ++  L Q ++   K
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644

Query: 739  MSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE 798
               E   +  G         R+  +  ++      +     + +++  L    + T   E
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704

Query: 799  AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEE---PAEPEDMERFEEMVVK 855
               +        +   +++  +T      +        + E    ++    E       K
Sbjct: 1705 Q--QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1762

Query: 856  VLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915
               +L+A    ++   EE ++L+   E+   +Q+ L EE DA  R+  E    L + +A 
Sbjct: 1763 SKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEE-DAA-RQRAEAERVLAEKLAA 1819

Query: 916  QNDKNEIK-ELQTKLRELQLQYQ----ASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
              +   +K E +  L+E + + +     + DE  +   ++EQ        +E L QLR+ 
Sbjct: 1820 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1879

Query: 971  RPSVVKEARG--KNANKNMNKNANGVKMKKVT--KPCSDTSESDLE----------TRKS 1016
              S ++  +G  ++  +   +    +   K +  K  +  +E +LE          T +S
Sbjct: 1880 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939

Query: 1017 LEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTE 1076
             E      A QR+   LA EEE++    EE+ Q    A+E+   +  A   + E  K+  
Sbjct: 1940 KEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996

Query: 1077 DQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
            ++     ++ E+E     +  ++ A   L++ E+ +   + + ++
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2041



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 172/853 (20%), Positives = 327/853 (38%), Gaps = 151/853 (17%)

Query: 301  QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS 360
            QQL  + EQ    +++CQ    EL+++            RLQ E  C    V R +    
Sbjct: 944  QQLLQSLEQGAQEESRCQRCISELKDI------------RLQLE-ACETRTVHRLRLPLD 990

Query: 361  VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQ-LKVMKSTLVENQSEKELL 419
                 E   R+   QK    +Q E   L K   +L  E  + L + + +        EL 
Sbjct: 991  KEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1046

Query: 420  CRLQKLHLQHQNVTCEKEKL------LERQQQLQEELQCHEAELQHLRDTVASFKESNEK 473
              L KL           EKL      +   Q  +E L+ HE +L+  +   A+  E    
Sbjct: 1047 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE---- 1102

Query: 474  DTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCA 533
                   L+  K   +  + + E Q+  +D L  +L   Q   + L+  H      G+  
Sbjct: 1103 -------LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH------GERD 1149

Query: 534  NKCDTLLSRLTELQEKYKA--SQKEMGQLQMEQC---------------ELLEDQRRMQE 576
             + +    R+ +L E+++A  +Q ++ Q ++EQ                  L+D RR QE
Sbjct: 1150 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1209

Query: 577  EQGQLQEELHRLTLPLPKSGL----LLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQ 632
               Q+Q       +PL  S      L + Q LL ++E   E     Q   ++    I++ 
Sbjct: 1210 ---QIQ------AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260

Query: 633  DCVL---KEQLE-IHEELRRFK-ESHFQEVLENPDDSKLAKSSKCNRNKQ-SKLLMEQMQ 686
            +  L   K QLE +    ++ K +S  + V++   D +   S       Q  K + E ++
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320

Query: 687  ALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGK 746
             ++        ++E L ++Q    EER+RL A+++  LE+ + L       K   E   K
Sbjct: 1321 RME--------EEERLAEQQ--RAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAK 1369

Query: 747  SYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCT 806
                 +   E   +  +  VD            Q   +S  +       +SEA       
Sbjct: 1370 ELQQRM--QEEVVRREEAAVD-----------AQQQKRSIQEELQQLRQSSEA------- 1409

Query: 807  TSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAM 866
                                           E  A+    E  E   +++  +++ V+  
Sbjct: 1410 -------------------------------EIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438

Query: 867  YQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQ 926
             + ++ +    + +++ L A+     EE +A +R+ +E  E L + +  ++ +    E++
Sbjct: 1439 LEATERQRGGAEGELQALRAR----AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1494

Query: 927  TKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
               R ++ + +A+ ++Q R L   E+L  Q +  +  LRQ   +R   V+ A      + 
Sbjct: 1495 LASR-VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVAL-----ET 1547

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETRKS-LEVVLYYKASQRKLDGLAKEEEKKEEMEE 1045
              ++A      K       T++ +   ++  + V    + ++R+    A+ E  +EE E 
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607

Query: 1046 EKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSL 1105
            E ++ + +A E     L AE    +++ +  + E+ +E+ E E +     EE+      L
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1667

Query: 1106 ESPEENNPLRLSE 1118
               E     +L+E
Sbjct: 1668 AEQELEKQRQLAE 1680



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 58/300 (19%), Positives = 122/300 (40%), Gaps = 26/300 (8%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            + ++ E  L  L  EE +  ++E+ ++E +   Q   S     + + R +   + +LE+L
Sbjct: 2438 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2497

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
                +    +L E ++   Q           +E ER       E   ++  + +  +R  
Sbjct: 2498 FQDEVAKAQQLREEQQRQQQQ----------MEQERQRLVASMEEARRRQHEAEEGVRRK 2547

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            +EE+  LE ++  + + + +E    + ++Q L +    +    E   AS       + N 
Sbjct: 2548 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2607

Query: 182  LEDMERIRGDYEME--IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLN-- 237
             + ++    + E E     LR ++  +  + +G L         EELQ L + +  ++  
Sbjct: 2608 RDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS-------AEELQRLAQGHTTVDEL 2660

Query: 238  ---EEYRALQESNSSLTGQLADLESER--TQRATERWLQSQTLSMTSAESQTSEMDFLEP 292
               E+ R   +  SS+ G L    +E+     A +R L S   ++   E+Q +    L+P
Sbjct: 2661 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2720


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  132 bits (331), Expect = 2e-30
 Identities = 258/1235 (20%), Positives = 489/1235 (39%), Gaps = 136/1235 (11%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            Q+ E E+   A   + E  E     +EEE   V+    +   +  + RG +  E EL+ L
Sbjct: 1413 QSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVR----LQLEATERQRGGA--EGELQAL 1464

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
            RA+     AE  E ++   Q E + L  Q   E +R    +QAEV  +   +++ E  + 
Sbjct: 1465 RAR-----AEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV--ELASRVKAEAEAA 1514

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            RE+   L+  +E  L+  E E  L QAE++  RQ      T   S  A LQ        +
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574

Query: 182  LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHF-LNEEY 240
               +ER   +  + +A LR E E ++ + +      +    +EE +   ER+    NE  
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQA------EAERAREEAERELERWQLKANEAL 1628

Query: 241  RA-LQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
            R  LQ    +    LA  E+E+ +   ER    +      AE Q      L  + E++  
Sbjct: 1629 RLRLQAEEVAQQKSLAQAEAEKQKEEAER----EARRRGKAEEQAVRQRELA-EQELEKQ 1683

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA--QNEVLRFQT 357
            RQ      +Q    + +   L  E E+ +  RQ+ EEE  RLQRE   A  + + L  + 
Sbjct: 1684 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1743

Query: 358  SHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE 417
            +    + E L +     +++  ++ ++  + L+ +     EL +       L E    + 
Sbjct: 1744 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803

Query: 418  LLCR--LQKLHLQHQNVTCEKEKLLERQQQLQEE----LQCHEAELQHLR----DTVASF 467
             L      +   + + V  EK   +    +L+ E    L+  EAE + LR    D     
Sbjct: 1804 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1863

Query: 468  KESNEKDTETHAQLQE-MKQLYQASKDELERQKHMYD-------QLEQDLLLCQLELKEL 519
            +   E+  +  A ++E + QL +AS  ELERQK + +       Q+E+++L  +   ++ 
Sbjct: 1864 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923

Query: 520  KASHPIPE-DKGKC-ANKCDTLLSR-----------------------LTELQEKYKASQ 554
             A     E + G+  +N  DTL S+                         E  +K  A++
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983

Query: 555  KEMGQLQMEQCELLEDQRRMQEEQGQL-----QEELHRLTLPLPKSGLLLKSQELLTKLE 609
            +E  + +    E +E  +   EE  +L     QE   +L L    +   L+++E      
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043

Query: 610  DLCELQLLYQGMQEEQKKL--IQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLA 667
               + Q L Q +Q+EQ  L  ++ +    +   E  EE R   E    +     ++++  
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2103

Query: 668  KSS---KCNRNKQSKLLMEQM--QALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQL 722
            K S   +     Q++   E++  +A Q      QA+Q  L+Q+Q    E  K  +   Q 
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2163

Query: 723  CLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTS 782
              ++ Q+ Q +  ++++ LE        +    +  +              +   S +  
Sbjct: 2164 LRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222

Query: 783  SKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAE 842
             +   K      +  EA  ++       +        +       +++   S   +E A 
Sbjct: 2223 MEELSKL----KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2278

Query: 843  -----PEDMERFEEMVVKVLI-KLQAVQ------AMYQISQEEHSQLQEQMEKLLAKQKD 890
                  ED+ +   +  K+L  K+QAVQ      A  ++ Q++    QEQ  +L   ++ 
Sbjct: 2279 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338

Query: 891  LKEELDACEREFKECMEC-----LEKPMAPQNDKNEIKEL---QTKLRELQLQYQASMDE 942
            + ++L    + F+  +E      LE     +  K  + E+   Q +  E   +++   +E
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2398

Query: 943  QGRLL-----------VVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNM---- 987
             G  L            + + LE Q Q    +  +LRE    + +E         +    
Sbjct: 2399 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2458

Query: 988  NKNANGVKMKKVTKPCSDTSESDLETRKSL-EVVLYYKASQRKLDGLAKEEEKKEEMEEE 1046
            ++    V+ +++ +      +S L  + SL +   + +  + KL+ L ++E  K +   E
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2518

Query: 1047 KKQVKEEAKEQCGDELVA-------EPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEED 1099
            ++Q +++  EQ    LVA          + EE    + +E  + +++  ++EE   EE  
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2578

Query: 1100 DADSSLESPEENNPLRLSESKKSSPTPNPPIFSLP 1134
                 L+  EE +   L+ S++ + +      +LP
Sbjct: 2579 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2613



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 218/1125 (19%), Positives = 442/1125 (39%), Gaps = 149/1125 (13%)

Query: 55   ETELEELRAQVLQLVAELEETREL-----AGQHEDDSLELQ-GLLEDERLASAQQAEVFT 108
            + E+E L   V +L AE E+   L     A       LEL  G LE  R  SA    ++ 
Sbjct: 1016 QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA----IYL 1071

Query: 109  KQIQQLQGELRSLREEISLLEHEKESELKEIEQ------ELHLAQAEIQSLRQAAEDSAT 162
            ++++ +   +R  +    +L   +E +LKE +       EL   +A ++ LR  AE    
Sbjct: 1072 EKLKTISLVIRGTQGAEEVLRAHEE-QLKEAQAVPATLPELEATKASLKKLRAQAE---- 1126

Query: 163  EHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGL 222
              +    +L+++L   Q   E +++  G+ ++E+   R  +          L  +D    
Sbjct: 1127 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-- 1184

Query: 223  QEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAES 282
            Q EL++L         + R  +ES   L   L D           R  Q Q  +M  A+S
Sbjct: 1185 QRELEQL-------GRQLRYYRESADPLGAWLQDA----------RRRQEQIQAMPLADS 1227

Query: 283  QTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQ 342
            Q               +R+QLR  +                LEE++ H +  EE QR  +
Sbjct: 1228 QA--------------VREQLRQEQAL--------------LEEIERHGEKVEECQRFAK 1259

Query: 343  RELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQL 402
            + +   ++  L+  T  +  +     ++   +Q   ++   E  +L     +L T   Q 
Sbjct: 1260 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1319

Query: 403  KVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQL---------QEELQCH 453
                S  +    E+E L   Q+   + +    E E  LE+Q+QL         Q E +  
Sbjct: 1320 IKFISETLRRMEEEERLAEQQR--AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1377

Query: 454  EAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQ 513
            E + +   + V   + + +   +  +  +E++QL Q+S+ E++ +    +  E+  L  +
Sbjct: 1378 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1437

Query: 514  LELKELKASHPIPE-DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQR 572
             E++ ++      E  +G    +   L +R  E + + + +Q+E  +L          +R
Sbjct: 1438 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL----------RR 1487

Query: 573  RMQEE-QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQN 631
            ++Q+E Q + Q E+   +    ++    + Q  L  LE+L  LQ       EE ++ ++ 
Sbjct: 1488 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQ------AEEAERRLRQ 1540

Query: 632  QDCVLKEQLEIH-EELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV 690
             +     Q+++  E  +R  E+  Q        SK A  ++     +  L  E +   Q+
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQ--------SKRASFAEKTAQLERSLQEEHVAVAQL 1592

Query: 691  MYDAGQAKQELLQQEQGRLLEERK------------RLQADLQLCLEEMQLLQVQSPSIK 738
              +A +  Q+  + E+ R   ER+            RL+   +   ++  L Q ++   K
Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652

Query: 739  MSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE 798
               E   +  G         R+  +  ++      +     + +++  L    + T   E
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712

Query: 799  AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEE---PAEPEDMERFEEMVVK 855
               +        +   +++  +T      +        + E    ++    E       K
Sbjct: 1713 Q--QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1770

Query: 856  VLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915
               +L+A    ++   EE ++L+   E+   +Q+ L EE DA  R+  E    L + +A 
Sbjct: 1771 SKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEE-DAA-RQRAEAERVLAEKLAA 1827

Query: 916  QNDKNEIK-ELQTKLRELQLQYQ----ASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
              +   +K E +  L+E + + +     + DE  +   ++EQ        +E L QLR+ 
Sbjct: 1828 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887

Query: 971  RPSVVKEARG--KNANKNMNKNANGVKMKKVT--KPCSDTSESDLE----------TRKS 1016
              S ++  +G  ++  +   +    +   K +  K  +  +E +LE          T +S
Sbjct: 1888 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947

Query: 1017 LEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTE 1076
             E      A QR+   LA EEE++    EE+ Q    A+E+   +  A   + E  K+  
Sbjct: 1948 KEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2004

Query: 1077 DQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
            ++     ++ E+E     +  ++ A   L++ E+ +   + + ++
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2049



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 172/853 (20%), Positives = 327/853 (38%), Gaps = 151/853 (17%)

Query: 301  QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS 360
            QQL  + EQ    +++CQ    EL+++            RLQ E  C    V R +    
Sbjct: 952  QQLLQSLEQGAQEESRCQRCISELKDI------------RLQLE-ACETRTVHRLRLPLD 998

Query: 361  VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQ-LKVMKSTLVENQSEKELL 419
                 E   R+   QK    +Q E   L K   +L  E  + L + + +        EL 
Sbjct: 999  KEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1054

Query: 420  CRLQKLHLQHQNVTCEKEKL------LERQQQLQEELQCHEAELQHLRDTVASFKESNEK 473
              L KL           EKL      +   Q  +E L+ HE +L+  +   A+  E    
Sbjct: 1055 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE---- 1110

Query: 474  DTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCA 533
                   L+  K   +  + + E Q+  +D L  +L   Q   + L+  H      G+  
Sbjct: 1111 -------LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH------GERD 1157

Query: 534  NKCDTLLSRLTELQEKYKA--SQKEMGQLQMEQC---------------ELLEDQRRMQE 576
             + +    R+ +L E+++A  +Q ++ Q ++EQ                  L+D RR QE
Sbjct: 1158 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1217

Query: 577  EQGQLQEELHRLTLPLPKSGL----LLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQ 632
               Q+Q       +PL  S      L + Q LL ++E   E     Q   ++    I++ 
Sbjct: 1218 ---QIQ------AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268

Query: 633  DCVL---KEQLE-IHEELRRFK-ESHFQEVLENPDDSKLAKSSKCNRNKQ-SKLLMEQMQ 686
            +  L   K QLE +    ++ K +S  + V++   D +   S       Q  K + E ++
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1328

Query: 687  ALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGK 746
             ++        ++E L ++Q    EER+RL A+++  LE+ + L       K   E   K
Sbjct: 1329 RME--------EEERLAEQQ--RAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAK 1377

Query: 747  SYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCT 806
                 +   E   +  +  VD            Q   +S  +       +SEA       
Sbjct: 1378 ELQQRM--QEEVVRREEAAVD-----------AQQQKRSIQEELQQLRQSSEA------- 1417

Query: 807  TSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAM 866
                                           E  A+    E  E   +++  +++ V+  
Sbjct: 1418 -------------------------------EIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446

Query: 867  YQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQ 926
             + ++ +    + +++ L A+     EE +A +R+ +E  E L + +  ++ +    E++
Sbjct: 1447 LEATERQRGGAEGELQALRAR----AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1502

Query: 927  TKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
               R ++ + +A+ ++Q R L   E+L  Q +  +  LRQ   +R   V+ A      + 
Sbjct: 1503 LASR-VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVAL-----ET 1555

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETRKS-LEVVLYYKASQRKLDGLAKEEEKKEEMEE 1045
              ++A      K       T++ +   ++  + V    + ++R+    A+ E  +EE E 
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615

Query: 1046 EKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSL 1105
            E ++ + +A E     L AE    +++ +  + E+ +E+ E E +     EE+      L
Sbjct: 1616 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1675

Query: 1106 ESPEENNPLRLSE 1118
               E     +L+E
Sbjct: 1676 AEQELEKQRQLAE 1688



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 58/300 (19%), Positives = 122/300 (40%), Gaps = 26/300 (8%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            + ++ E  L  L  EE +  ++E+ ++E +   Q   S     + + R +   + +LE+L
Sbjct: 2446 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2505

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
                +    +L E ++   Q           +E ER       E   ++  + +  +R  
Sbjct: 2506 FQDEVAKAQQLREEQQRQQQQ----------MEQERQRLVASMEEARRRQHEAEEGVRRK 2555

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            +EE+  LE ++  + + + +E    + ++Q L +    +    E   AS       + N 
Sbjct: 2556 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2615

Query: 182  LEDMERIRGDYEME--IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLN-- 237
             + ++    + E E     LR ++  +  + +G L         EELQ L + +  ++  
Sbjct: 2616 RDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS-------AEELQRLAQGHTTVDEL 2668

Query: 238  ---EEYRALQESNSSLTGQLADLESER--TQRATERWLQSQTLSMTSAESQTSEMDFLEP 292
               E+ R   +  SS+ G L    +E+     A +R L S   ++   E+Q +    L+P
Sbjct: 2669 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2728


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  132 bits (331), Expect = 2e-30
 Identities = 258/1235 (20%), Positives = 489/1235 (39%), Gaps = 136/1235 (11%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            Q+ E E+   A   + E  E     +EEE   V+    +   +  + RG +  E EL+ L
Sbjct: 1454 QSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVR----LQLEATERQRGGA--EGELQAL 1505

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
            RA+     AE  E ++   Q E + L  Q   E +R    +QAEV  +   +++ E  + 
Sbjct: 1506 RAR-----AEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV--ELASRVKAEAEAA 1555

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            RE+   L+  +E  L+  E E  L QAE++  RQ      T   S  A LQ        +
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615

Query: 182  LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHF-LNEEY 240
               +ER   +  + +A LR E E ++ + +      +    +EE +   ER+    NE  
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQA------EAERAREEAERELERWQLKANEAL 1669

Query: 241  RA-LQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
            R  LQ    +    LA  E+E+ +   ER    +      AE Q      L  + E++  
Sbjct: 1670 RLRLQAEEVAQQKSLAQAEAEKQKEEAER----EARRRGKAEEQAVRQRELA-EQELEKQ 1724

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA--QNEVLRFQT 357
            RQ      +Q    + +   L  E E+ +  RQ+ EEE  RLQRE   A  + + L  + 
Sbjct: 1725 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1784

Query: 358  SHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE 417
            +    + E L +     +++  ++ ++  + L+ +     EL +       L E    + 
Sbjct: 1785 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844

Query: 418  LLCR--LQKLHLQHQNVTCEKEKLLERQQQLQEE----LQCHEAELQHLR----DTVASF 467
             L      +   + + V  EK   +    +L+ E    L+  EAE + LR    D     
Sbjct: 1845 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1904

Query: 468  KESNEKDTETHAQLQE-MKQLYQASKDELERQKHMYD-------QLEQDLLLCQLELKEL 519
            +   E+  +  A ++E + QL +AS  ELERQK + +       Q+E+++L  +   ++ 
Sbjct: 1905 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964

Query: 520  KASHPIPE-DKGKC-ANKCDTLLSR-----------------------LTELQEKYKASQ 554
             A     E + G+  +N  DTL S+                         E  +K  A++
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024

Query: 555  KEMGQLQMEQCELLEDQRRMQEEQGQL-----QEELHRLTLPLPKSGLLLKSQELLTKLE 609
            +E  + +    E +E  +   EE  +L     QE   +L L    +   L+++E      
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084

Query: 610  DLCELQLLYQGMQEEQKKL--IQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLA 667
               + Q L Q +Q+EQ  L  ++ +    +   E  EE R   E    +     ++++  
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2144

Query: 668  KSS---KCNRNKQSKLLMEQM--QALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQL 722
            K S   +     Q++   E++  +A Q      QA+Q  L+Q+Q    E  K  +   Q 
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2204

Query: 723  CLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTS 782
              ++ Q+ Q +  ++++ LE        +    +  +              +   S +  
Sbjct: 2205 LRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263

Query: 783  SKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAE 842
             +   K      +  EA  ++       +        +       +++   S   +E A 
Sbjct: 2264 MEELSKL----KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2319

Query: 843  -----PEDMERFEEMVVKVLI-KLQAVQ------AMYQISQEEHSQLQEQMEKLLAKQKD 890
                  ED+ +   +  K+L  K+QAVQ      A  ++ Q++    QEQ  +L   ++ 
Sbjct: 2320 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379

Query: 891  LKEELDACEREFKECMEC-----LEKPMAPQNDKNEIKEL---QTKLRELQLQYQASMDE 942
            + ++L    + F+  +E      LE     +  K  + E+   Q +  E   +++   +E
Sbjct: 2380 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439

Query: 943  QGRLL-----------VVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNM---- 987
             G  L            + + LE Q Q    +  +LRE    + +E         +    
Sbjct: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2499

Query: 988  NKNANGVKMKKVTKPCSDTSESDLETRKSL-EVVLYYKASQRKLDGLAKEEEKKEEMEEE 1046
            ++    V+ +++ +      +S L  + SL +   + +  + KL+ L ++E  K +   E
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559

Query: 1047 KKQVKEEAKEQCGDELVA-------EPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEED 1099
            ++Q +++  EQ    LVA          + EE    + +E  + +++  ++EE   EE  
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2619

Query: 1100 DADSSLESPEENNPLRLSESKKSSPTPNPPIFSLP 1134
                 L+  EE +   L+ S++ + +      +LP
Sbjct: 2620 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2654



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 218/1125 (19%), Positives = 442/1125 (39%), Gaps = 149/1125 (13%)

Query: 55   ETELEELRAQVLQLVAELEETREL-----AGQHEDDSLELQ-GLLEDERLASAQQAEVFT 108
            + E+E L   V +L AE E+   L     A       LEL  G LE  R  SA    ++ 
Sbjct: 1057 QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA----IYL 1112

Query: 109  KQIQQLQGELRSLREEISLLEHEKESELKEIEQ------ELHLAQAEIQSLRQAAEDSAT 162
            ++++ +   +R  +    +L   +E +LKE +       EL   +A ++ LR  AE    
Sbjct: 1113 EKLKTISLVIRGTQGAEEVLRAHEE-QLKEAQAVPATLPELEATKASLKKLRAQAE---- 1167

Query: 163  EHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGL 222
              +    +L+++L   Q   E +++  G+ ++E+   R  +          L  +D    
Sbjct: 1168 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-- 1225

Query: 223  QEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAES 282
            Q EL++L         + R  +ES   L   L D           R  Q Q  +M  A+S
Sbjct: 1226 QRELEQL-------GRQLRYYRESADPLGAWLQDA----------RRRQEQIQAMPLADS 1268

Query: 283  QTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQ 342
            Q               +R+QLR  +                LEE++ H +  EE QR  +
Sbjct: 1269 QA--------------VREQLRQEQAL--------------LEEIERHGEKVEECQRFAK 1300

Query: 343  RELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQL 402
            + +   ++  L+  T  +  +     ++   +Q   ++   E  +L     +L T   Q 
Sbjct: 1301 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1360

Query: 403  KVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQL---------QEELQCH 453
                S  +    E+E L   Q+   + +    E E  LE+Q+QL         Q E +  
Sbjct: 1361 IKFISETLRRMEEEERLAEQQR--AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1418

Query: 454  EAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQ 513
            E + +   + V   + + +   +  +  +E++QL Q+S+ E++ +    +  E+  L  +
Sbjct: 1419 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478

Query: 514  LELKELKASHPIPE-DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQR 572
             E++ ++      E  +G    +   L +R  E + + + +Q+E  +L          +R
Sbjct: 1479 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL----------RR 1528

Query: 573  RMQEE-QGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQN 631
            ++Q+E Q + Q E+   +    ++    + Q  L  LE+L  LQ       EE ++ ++ 
Sbjct: 1529 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-RLQ------AEEAERRLRQ 1581

Query: 632  QDCVLKEQLEIH-EELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV 690
             +     Q+++  E  +R  E+  Q        SK A  ++     +  L  E +   Q+
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQ--------SKRASFAEKTAQLERSLQEEHVAVAQL 1633

Query: 691  MYDAGQAKQELLQQEQGRLLEERK------------RLQADLQLCLEEMQLLQVQSPSIK 738
              +A +  Q+  + E+ R   ER+            RL+   +   ++  L Q ++   K
Sbjct: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1693

Query: 739  MSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE 798
               E   +  G         R+  +  ++      +     + +++  L    + T   E
Sbjct: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753

Query: 799  AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEE---PAEPEDMERFEEMVVK 855
               +        +   +++  +T      +        + E    ++    E       K
Sbjct: 1754 Q--QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1811

Query: 856  VLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915
               +L+A    ++   EE ++L+   E+   +Q+ L EE DA  R+  E    L + +A 
Sbjct: 1812 SKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEE-DAA-RQRAEAERVLAEKLAA 1868

Query: 916  QNDKNEIK-ELQTKLRELQLQYQ----ASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
              +   +K E +  L+E + + +     + DE  +   ++EQ        +E L QLR+ 
Sbjct: 1869 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1928

Query: 971  RPSVVKEARG--KNANKNMNKNANGVKMKKVT--KPCSDTSESDLE----------TRKS 1016
              S ++  +G  ++  +   +    +   K +  K  +  +E +LE          T +S
Sbjct: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988

Query: 1017 LEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTE 1076
             E      A QR+   LA EEE++    EE+ Q    A+E+   +  A   + E  K+  
Sbjct: 1989 KEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045

Query: 1077 DQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
            ++     ++ E+E     +  ++ A   L++ E+ +   + + ++
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2090



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 172/853 (20%), Positives = 327/853 (38%), Gaps = 151/853 (17%)

Query: 301  QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS 360
            QQL  + EQ    +++CQ    EL+++            RLQ E  C    V R +    
Sbjct: 993  QQLLQSLEQGAQEESRCQRCISELKDI------------RLQLE-ACETRTVHRLRLPLD 1039

Query: 361  VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQ-LKVMKSTLVENQSEKELL 419
                 E   R+   QK    +Q E   L K   +L  E  + L + + +        EL 
Sbjct: 1040 KEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1095

Query: 420  CRLQKLHLQHQNVTCEKEKL------LERQQQLQEELQCHEAELQHLRDTVASFKESNEK 473
              L KL           EKL      +   Q  +E L+ HE +L+  +   A+  E    
Sbjct: 1096 LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE---- 1151

Query: 474  DTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCA 533
                   L+  K   +  + + E Q+  +D L  +L   Q   + L+  H      G+  
Sbjct: 1152 -------LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH------GERD 1198

Query: 534  NKCDTLLSRLTELQEKYKA--SQKEMGQLQMEQC---------------ELLEDQRRMQE 576
             + +    R+ +L E+++A  +Q ++ Q ++EQ                  L+D RR QE
Sbjct: 1199 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1258

Query: 577  EQGQLQEELHRLTLPLPKSGL----LLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQ 632
               Q+Q       +PL  S      L + Q LL ++E   E     Q   ++    I++ 
Sbjct: 1259 ---QIQ------AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309

Query: 633  DCVL---KEQLE-IHEELRRFK-ESHFQEVLENPDDSKLAKSSKCNRNKQ-SKLLMEQMQ 686
            +  L   K QLE +    ++ K +S  + V++   D +   S       Q  K + E ++
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369

Query: 687  ALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGK 746
             ++        ++E L ++Q    EER+RL A+++  LE+ + L       K   E   K
Sbjct: 1370 RME--------EEERLAEQQ--RAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAK 1418

Query: 747  SYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCT 806
                 +   E   +  +  VD            Q   +S  +       +SEA       
Sbjct: 1419 ELQQRM--QEEVVRREEAAVD-----------AQQQKRSIQEELQQLRQSSEA------- 1458

Query: 807  TSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAM 866
                                           E  A+    E  E   +++  +++ V+  
Sbjct: 1459 -------------------------------EIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487

Query: 867  YQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQ 926
             + ++ +    + +++ L A+     EE +A +R+ +E  E L + +  ++ +    E++
Sbjct: 1488 LEATERQRGGAEGELQALRAR----AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543

Query: 927  TKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
               R ++ + +A+ ++Q R L   E+L  Q +  +  LRQ   +R   V+ A      + 
Sbjct: 1544 LASR-VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVAL-----ET 1596

Query: 987  MNKNANGVKMKKVTKPCSDTSESDLETRKS-LEVVLYYKASQRKLDGLAKEEEKKEEMEE 1045
              ++A      K       T++ +   ++  + V    + ++R+    A+ E  +EE E 
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656

Query: 1046 EKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSL 1105
            E ++ + +A E     L AE    +++ +  + E+ +E+ E E +     EE+      L
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716

Query: 1106 ESPEENNPLRLSE 1118
               E     +L+E
Sbjct: 1717 AEQELEKQRQLAE 1729



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 58/300 (19%), Positives = 122/300 (40%), Gaps = 26/300 (8%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            + ++ E  L  L  EE +  ++E+ ++E +   Q   S     + + R +   + +LE+L
Sbjct: 2487 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2546

Query: 62   RAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
                +    +L E ++   Q           +E ER       E   ++  + +  +R  
Sbjct: 2547 FQDEVAKAQQLREEQQRQQQQ----------MEQERQRLVASMEEARRRQHEAEEGVRRK 2596

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNE 181
            +EE+  LE ++  + + + +E    + ++Q L +    +    E   AS       + N 
Sbjct: 2597 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2656

Query: 182  LEDMERIRGDYEME--IASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLN-- 237
             + ++    + E E     LR ++  +  + +G L         EELQ L + +  ++  
Sbjct: 2657 RDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS-------AEELQRLAQGHTTVDEL 2709

Query: 238  ---EEYRALQESNSSLTGQLADLESER--TQRATERWLQSQTLSMTSAESQTSEMDFLEP 292
               E+ R   +  SS+ G L    +E+     A +R L S   ++   E+Q +    L+P
Sbjct: 2710 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDP 2769


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  129 bits (325), Expect = 1e-29
 Identities = 256/1213 (21%), Positives = 490/1213 (40%), Gaps = 179/1213 (14%)

Query: 15   EEEEEEEEEEEEVEEEEEQVQK-----GGSVGSLSVNKHRGLSLTETELEELRAQVLQLV 69
            ++E +   E    EEE++Q+         S+ +LS  K      ++     L AQV  L 
Sbjct: 445  QQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT 504

Query: 70   AELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLE 129
            +EL        Q +    EL GL +  +   AQ A+   +Q Q  QG LR   E++S   
Sbjct: 505  SELTTLNATIQQQDQ---ELAGLKQQAKEKQAQLAQTLQQQEQASQG-LRHQVEQLSSSL 560

Query: 130  HEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIR 189
             +KE +LKE+      A+ +  + +  A+  AT  E   ASL+E        L+ +E + 
Sbjct: 561  KQKEQQLKEV------AEKQEATRQDHAQQLATAAEEREASLRE----RDAALKQLEALE 610

Query: 190  GDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSS 249
             +   ++  L+ ++++ +     +   +  +  Q E  EL  +   L       ++    
Sbjct: 611  KEKAAKLEILQQQLQVANEARDSAQ--TSVTQAQREKAELSRKVEELQACVETARQEQHE 668

Query: 250  LTGQLADLESE---RTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDA 306
               Q+A+LE +     Q+ATE+   +Q       + Q  +         ++  +++  DA
Sbjct: 669  AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728

Query: 307  EEQMHGMKNKC-QELCCELEEL--QHHRQVSEEEQRRLQR-----------ELKCAQNEV 352
             E+    + +C  EL  E   L  QH R+  E E+ R  R           E   A+ EV
Sbjct: 729  LEE----QQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEV 784

Query: 353  LRFQTSHSV-------TQNEELKSRLCTLQKKYDTSQDE--------QNELLKMQLQLQT 397
            LR + + ++       ++ E+L   +   +++Y+ SQ E        Q +L+ ++ + + 
Sbjct: 785  LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK 844

Query: 398  ELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQ-QQLQEELQCHEAE 456
              ++L+  K  +   +S  EL    Q      QN   E    L R  QQ+QE+    E  
Sbjct: 845  ARQELQEAKEKVAGIESHSELQISRQ------QNELAELHANLARALQQVQEK----EVR 894

Query: 457  LQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLEL 516
             Q L D +++ +E   K   T  ++  ++ L + + ++ E                +L  
Sbjct: 895  AQKLADDLSTLQE---KMAATSKEVARLETLVRKAGEQQETASR------------ELVK 939

Query: 517  KELKASHPIPE--DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRM 574
            +  +A    PE  ++ +    C T  +    LQ   + +++   +L+  +  L+E Q + 
Sbjct: 940  EPARAGDRQPEWLEEQQGRQFCSTQAA----LQAMEREAEQMGNELERLRAALMESQGQQ 995

Query: 575  QEEQGQLQEELHRLT---------LPLPKSG---LLLKSQ--------ELLTKLEDLCEL 614
            QEE+GQ + E+ RLT         L L K+    L ++ Q        E  T  E L   
Sbjct: 996  QEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHA 1055

Query: 615  QLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNR 674
                +G  +E  KL   +   +KE  E+ + +++ KE   ++  E+   S  A+S    R
Sbjct: 1056 LTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG-AQSEAAGR 1114

Query: 675  NKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQ------ 728
             + +   +E ++A     +    KQ+       R LE  +  +A+    LE +Q      
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEK 1174

Query: 729  ------------LLQVQSPSIKMSLESYGKSY-----------------GSMVPSNENCR 759
                          Q +  + +  ++ + K+                   S++ S E   
Sbjct: 1175 AQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV 1234

Query: 760  KTYDTTVDDNESYYKSY-----TSTQTSSK-----SFLKSYDSSTSASEAYGKSYCTTSN 809
               +  V + E   K         ++ S K       L++  +S SA  A   S      
Sbjct: 1235 SILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEV 1294

Query: 810  SSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQI 869
             S+  +      +S +  Q+  ++S  +      ++++ ++E   K   K QA+  +   
Sbjct: 1295 QSLREEAEKQRVASENLRQE--LTSQAERAEELGQELKAWQE---KFFQKEQALSTL--- 1346

Query: 870  SQEEHSQLQEQMEKLLAKQ---KDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQ 926
             Q EH+  Q  + +LL  +   + L+ E  A E+  +E +E  +   A    + E+   Q
Sbjct: 1347 -QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELE--QSKQAAGGLRAELLRAQ 1403

Query: 927  TKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKN 986
             +L EL +  +  + EQ R     +QL  +     E+L  L++    + +E RG     N
Sbjct: 1404 RELGEL-IPLRQKVAEQER---TAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN 1459

Query: 987  MNKNANGVKMKKVTKPCSD---TSESDLETRKSLEVVLYYKASQRKLDGL-AKEEEKKEE 1042
            + +    V++ +  +          +D ETR + EV    +++ R+L+ + AK E  K +
Sbjct: 1460 LGRQFLEVELDQAREKYVQELAAVRADAETRLA-EVQREAQSTARELEVMTAKYEGAKVK 1518

Query: 1043 MEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDAD 1102
            + EE+++ +EE ++        E    E+ K  E+  +   D ++  K +  + +   A 
Sbjct: 1519 VLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQ 1578

Query: 1103 SSLESPEENNPLR 1115
               ES +E   L+
Sbjct: 1579 GG-ESQQEAQRLQ 1590



 Score =  122 bits (306), Expect = 2e-27
 Identities = 231/1034 (22%), Positives = 424/1034 (41%), Gaps = 148/1034 (14%)

Query: 17   EEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELE--- 73
            E+++  E+E V +E++Q+Q+      L   K   L +T+  LEE + +    + E +   
Sbjct: 683  EQQKATEKERVAQEKDQLQE-----QLQALKE-SLKVTKGSLEEEKRRAADALEEQQRCI 736

Query: 74   -----ETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQL-QGELRSLREEIS- 126
                 ETR L  QH+ +  EL    E+ER A  +  E   +Q+ +  Q E   LR E++ 
Sbjct: 737  SELKAETRSLVEQHKRERKEL----EEER-AGRKGLEARLQQLGEAHQAETEVLRRELAE 791

Query: 127  --LLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELED 184
                +H  ESE +++ +E       + + R+  EDS  E     A  QE L  ++ E E 
Sbjct: 792  AMAAQHTAESECEQLVKE-------VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK 844

Query: 185  MERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRE---RYHFLNEEYR 241
              +   + + ++A + +  E++ S     L    ++ L   LQ+++E   R   L ++  
Sbjct: 845  ARQELQEAKEKVAGIESHSELQISRQQNELA-ELHANLARALQQVQEKEVRAQKLADDLS 903

Query: 242  ALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQ 301
             LQE  ++ + ++A LE+   +   ++   S+ L    A +   + ++LE     Q    
Sbjct: 904  TLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCST 963

Query: 302  Q--LRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSH 359
            Q  L+  E +   M N+ + L   L E Q  +Q   EE+ + +RE+     E  R Q   
Sbjct: 964  QAALQAMEREAEQMGNELERLRAALMESQGQQQ---EERGQQEREVARLTQERGRAQADL 1020

Query: 360  SVTQ--NEELKSRL-----------CTLQKKYDTSQDEQN----ELLKMQLQLQTELRQL 402
            ++ +    EL+ RL            TLQ+    +  E+     EL K++     ++++L
Sbjct: 1021 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL 1080

Query: 403  KVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLE----RQQQLQEELQCHEAELQ 458
            + ++ T+   +  KE L + +K H        E     E    + + L+ E+   E + Q
Sbjct: 1081 EELRQTV---KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ 1137

Query: 459  HLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKE 518
              ++   S + S E +  + A+     +  Q    +LE +       +  L   Q EL  
Sbjct: 1138 KQQEQADSLERSLEAERASRAERDSALETLQG---QLEEKAQELGHSQSALASAQRELAA 1194

Query: 519  LKAS---HPIPEDKGKC--------ANKCDTLLSRLTE---------------------- 545
             +     H   ED+ K         A + ++L+S L E                      
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL 1254

Query: 546  LQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKS--QE 603
            +  + + SQK   +L++ Q E   +  R  E    L+EE+  L     K  +  ++  QE
Sbjct: 1255 VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQE 1314

Query: 604  LLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDD 663
            L ++ E   EL    Q ++  Q+K  Q +  +   QLE         ++   E+L     
Sbjct: 1315 LTSQAERAEELG---QELKAWQEKFFQKEQALSTLQLE-----HTSTQALVSELLPAKHL 1366

Query: 664  SKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELL--QQEQGRLLEERKRLQADLQ 721
             +  ++ +    K+ +  +EQ +       AG  + ELL  Q+E G L+  R+++    +
Sbjct: 1367 CQQLQAEQAAAEKRHREELEQSKQA-----AGGLRAELLRAQRELGELIPLRQKVAEQER 1421

Query: 722  LCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENC-------RKTYDTTVDD-NESYY 773
                  Q L+ +  S    L    K++G +   N          R+  +  +D   E Y 
Sbjct: 1422 TA----QQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYV 1477

Query: 774  KSYTSTQTSSKSFL----KSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQK 829
            +   + +  +++ L    +   S+    E     Y       +  ++ +       T Q 
Sbjct: 1478 QELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV 1537

Query: 830  SFVSSCTDEEPAEPEDMERF---EEMVVKVLI-KLQAVQAMYQISQEEHSQLQEQMEKLL 885
              +     E+  + E++ +     +   KV   KL+AVQA    SQ+E  +LQ Q+ +L 
Sbjct: 1538 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNEL- 1596

Query: 886  AKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLREL-QLQYQASMDEQG 944
              Q  L ++  A E  +K  ME  +     +  +N+  ELQ +LR L QLQ      E  
Sbjct: 1597 --QAQLSQKEQAAE-HYKLQMEKAKTHYDAKKQQNQ--ELQEQLRSLEQLQ-----KENK 1646

Query: 945  RLLVVQEQLEGQLQ 958
             L    E+L  +LQ
Sbjct: 1647 ELRAEAERLGHELQ 1660



 Score =  120 bits (301), Expect = 7e-27
 Identities = 231/1181 (19%), Positives = 477/1181 (40%), Gaps = 160/1181 (13%)

Query: 15   EEEEEEEEEEEEVEEEEEQVQKGGSVGSLS--------VNKHRGLS-LTETELEELRAQV 65
            E    +E E E  E  +   +K   +  +         +N+ +  S L   ELEELR + 
Sbjct: 226  ERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKN 285

Query: 66   LQLVAELEET----RELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL 121
              L   L ET    ++L  +      ++  L E+    S +  E F   +QQLQ  L  L
Sbjct: 286  ESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLRE-FASHLQQLQDALNEL 344

Query: 122  REEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQ-N 180
             EE S    E   +  ++E+EL  A  +    ++  E+     +  ++ L+E L ++Q N
Sbjct: 345  TEEHSKATQEWLEKQAQLEKELSAALQD----KKCLEEKNEILQGKLSQLEEHLSQLQDN 400

Query: 181  ELEDMERIRGDYEMEIASLRAE---MEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLN 237
              ++   + GD  +++ +L+ E   +   +++    + + +    Q+E + L ER HF  
Sbjct: 401  PPQEKGEVLGDV-LQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHF-E 458

Query: 238  EEYRALQESNSSLTGQLADL-----ESERTQRATERWLQSQTLSMTSAESQTSEMDFLEP 292
            EE + L    + L   +++L     E E+  +A    L +Q  S+TS E  T      + 
Sbjct: 459  EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTS-ELTTLNATIQQQ 517

Query: 293  DPEMQLLRQQLRDAEEQM-----------HGMKNKCQELCCELEEL-QHHRQVSEEEQRR 340
            D E+  L+QQ ++ + Q+            G++++ ++L   L++  Q  ++V+E+++  
Sbjct: 518  DQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 577

Query: 341  LQ---RELKCAQNE-------------VLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDE 384
             Q   ++L  A  E              L         + E L+ +L    +  D++Q  
Sbjct: 578  RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTS 637

Query: 385  QNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQ---HQNVTCEKEKLLE 441
              +  + + +L  ++ +L+    T  + Q E +   ++ +L LQ    Q    EKE++ +
Sbjct: 638  VTQAQREKAELSRKVEELQACVETARQEQHEAQ--AQVAELELQLRSEQQKATEKERVAQ 695

Query: 442  RQQQLQEELQCHEAEL--------QHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKD 493
             + QLQE+LQ  +  L        +  R    + +E     +E  A+ + + + ++  + 
Sbjct: 696  EKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755

Query: 494  ELERQ----KHMYDQLEQ-------DLLLCQLELKELKASHPIPEDKGKCANKCDTLLSR 542
            ELE +    K +  +L+Q       +  + + EL E  A+    E      ++C+ L+  
Sbjct: 756  ELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE------SECEQLVKE 809

Query: 543  LTELQEKYKASQKEMGQL-QMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKS 601
            +   +E+Y+ SQ+E  Q   M Q +L+  +   ++ + +LQE   ++      S L +  
Sbjct: 810  VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISR 869

Query: 602  QE---------LLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRF--- 649
            Q+         L   L+ + E ++  Q + ++   L +      KE   +   +R+    
Sbjct: 870  QQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQ 929

Query: 650  KESHFQEVLENPD-------------------DSKLAKSSKCNRNKQSKLLMEQMQALQV 690
            +E+  +E+++ P                     ++ A  +     +Q    +E+++A  +
Sbjct: 930  QETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA-AL 988

Query: 691  MYDAGQAKQELLQQEQ--GRLLEERKRLQADLQL-----CLEEMQL---LQVQSPSIKMS 740
            M   GQ ++E  QQE+   RL +ER R QADL L        EM+L   L  Q       
Sbjct: 989  MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048

Query: 741  LESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAY 800
             E+   +       ++   K         +   +   + +   +   K      S S A 
Sbjct: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108

Query: 801  GKSYCTTSNSSITYKKSYGSTSS-SDTCQKSFVSSCTDEEPAEPEDMERFEEMVV----- 854
             ++   T  +    +      S     CQK    + + E   E E   R E         
Sbjct: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQ 1168

Query: 855  --------------KVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER 900
                            L   Q   A ++   ++HS+ +++ +  +A+ +   E  ++   
Sbjct: 1169 GQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228

Query: 901  EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC 960
              +E +  L + +  +  + E KEL+   R +  + + S   + RL ++Q +        
Sbjct: 1229 SLEEEVSILNRQVLEK--EGESKELK---RLVMAESEKSQKLEERLRLLQAETASNSARA 1283

Query: 961  QEELRQLREKRPSVVKEA---RGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSL 1017
             E    LRE+  S+ +EA   R  + N      +   + +++ +      E   +  ++L
Sbjct: 1284 AERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQAL 1343

Query: 1018 EVV-LYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQ 1057
              + L + ++Q  +  L   +   ++++ E+   ++  +E+
Sbjct: 1344 STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREE 1384



 Score =  119 bits (298), Expect = 2e-26
 Identities = 225/1123 (20%), Positives = 466/1123 (41%), Gaps = 114/1123 (10%)

Query: 12   ALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAE 71
            AL + E  E+E+  ++E  ++Q+Q          +    ++  + E  EL  +V +L A 
Sbjct: 602  ALKQLEALEKEKAAKLEILQQQLQVANEARD---SAQTSVTQAQREKAELSRKVEELQAC 658

Query: 72   LEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHE 131
            +E  R+   + +    EL+  L  E+  + ++  V  ++  QLQ +L++L+E + + +  
Sbjct: 659  VETARQEQHEAQAQVAELELQLRSEQQKATEKERV-AQEKDQLQEQLQALKESLKVTKGS 717

Query: 132  KESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGD 191
             E E +     L   Q  I  L+        +H+ +   L+E+    +     ++++   
Sbjct: 718  LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEA 777

Query: 192  YEMEIASLRAEM-EMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSL 250
            ++ E   LR E+ E  +++ +     S+   L +E+   RERY    +E     +  +  
Sbjct: 778  HQAETEVLRRELAEAMAAQHTAE---SECEQLVKEVAAWRERYEDSQQEE---AQYGAMF 831

Query: 251  TGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQM 310
              QL  L+ E  +   E  LQ     +   ES  SE+       E+  L   L  A +Q+
Sbjct: 832  QEQLMTLKEECEKARQE--LQEAKEKVAGIESH-SELQISRQQNELAELHANLARALQQV 888

Query: 311  HGMKNKCQELCCELEELQHHRQVSEEEQRRLQ-------RELKCAQNEVLRFQTSHSVTQ 363
               + + Q+L  +L  LQ     + +E  RL+        + + A  E+++        Q
Sbjct: 889  QEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQ 948

Query: 364  NEELKS----RLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELL 419
             E L+     + C+ Q      + E  ++     +L+  L + +  +      Q E+E+ 
Sbjct: 949  PEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQE-ERGQQEREVA 1007

Query: 420  CRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVA-SFKESNEKDTETH 478
               Q+      ++  EK    E + +LQ  L     E   L++ +A +  E   KD E  
Sbjct: 1008 RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE-- 1065

Query: 479  AQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGK---CANK 535
              L +++ L  A   ELE  +    QL++   L + E +    S    E  G+      K
Sbjct: 1066 --LAKLRGLEAAQIKELEELRQTVKQLKEQ--LAKKEKEHASGSGAQSEAAGRTEPTGPK 1121

Query: 536  CDTLLSRLTELQEKYKASQKEMG----QLQMEQCELLEDQRRMQEEQGQLQEELHRLTLP 591
             + L + +++L+++ +  Q++       L+ E+    E    ++  QGQL+E+     L 
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE--LG 1179

Query: 592  LPKSGLLLKSQELL---TKLEDLCELQ-----LLYQGMQEEQKK--LIQNQDCVLKEQLE 641
              +S L    +EL    TK++D  + +      + +G QE ++K  LI +    L+E++ 
Sbjct: 1180 HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISS----LEEEVS 1235

Query: 642  IHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQEL 701
            I            ++VLE   +SK  K      +++S+ L E+++ LQ    +  A    
Sbjct: 1236 ILN----------RQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA---- 1281

Query: 702  LQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKT 761
                  R  E    L+ ++Q   EE +  +V S +++  L S  +    +    +  ++ 
Sbjct: 1282 ------RAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEK 1335

Query: 762  YDTTVDDNESYYKSYTSTQT------SSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYK 815
            +        +    +TSTQ        +K   +   +  +A+E   +     S  +    
Sbjct: 1336 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGL 1395

Query: 816  KSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHS 875
            ++    +  +  +   +     E+    + +   +    +   +L  ++  + +  EE+ 
Sbjct: 1396 RAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAE---QLSMLKKAHGLLAEENR 1452

Query: 876  QLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQL- 934
             L E+    L +Q  L+ ELD    ++ + +  +      +  + + +E Q+  REL++ 
Sbjct: 1453 GLGERAN--LGRQ-FLEVELDQAREKYVQELAAVRADAETRLAEVQ-REAQSTARELEVM 1508

Query: 935  --QYQAS----MDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMN 988
              +Y+ +    ++E+ R    +++L  Q+    E+L   + ++   V+E   K A+ +  
Sbjct: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQV----EQLEVFQREQTKQVEELSKKLADSD-- 1562

Query: 989  KNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKK 1048
              A+ V+ +K+    +   ES  E ++           Q +L+ L  +  +KE+  E  K
Sbjct: 1563 -QASKVQQQKLKAVQAQGGESQQEAQR----------LQAQLNELQAQLSQKEQAAEHYK 1611

Query: 1049 QVKEEAKEQCGDELVAEPADPEEAKSTED-QEENEEDKEEEEK 1090
               E+AK     +        E+ +S E  Q+EN+E + E E+
Sbjct: 1612 LQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAER 1654



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 221/1060 (20%), Positives = 404/1060 (38%), Gaps = 137/1060 (12%)

Query: 110  QIQQLQGEL---RSLREEISLLEHEKESELKEIEQELHLAQAEIQSL-----RQAAEDSA 161
            Q+++L+ +L   RS R+E+ L   E    L E + ++ + Q  I  L     +QAA    
Sbjct: 215  QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274

Query: 162  TEHESDIASLQEDLCRMQNEL----EDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGL- 216
             +   ++    E L    +E     +D++  +   + +I  L        SE +G L   
Sbjct: 275  PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQL--------SEENGDLSFK 326

Query: 217  -----SDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQL-ADLESERTQRATERWL 270
                 S    LQ+ L EL E +    +E+    E  + L  +L A L+ ++        L
Sbjct: 327  LREFASHLQQLQDALNELTEEHSKATQEWL---EKQAQLEKELSAALQDKKCLEEKNEIL 383

Query: 271  QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH 330
            Q +   ++  E   S++    P  + ++L   L     Q+  +K +   L     +LQ  
Sbjct: 384  QGK---LSQLEEHLSQLQDNPPQEKGEVLGDVL-----QLETLKQEAATLAANNTQLQAR 435

Query: 331  RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK 390
             ++ E E  R Q+E K      L  +  H   + ++L S +  LQ         + EL +
Sbjct: 436  VEMLETE--RGQQEAK------LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQ 487

Query: 391  MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL 450
                 Q    +L    ++L       EL      +  Q Q +   K++  E+Q QL + L
Sbjct: 488  AS---QAHGARLTAQVASLTS-----ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTL 539

Query: 451  QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASK-DELERQKHMYDQLEQDL 509
            Q  E   Q LR  V     S ++  +   QL+E+ +  +A++ D  ++     ++ E  L
Sbjct: 540  QQQEQASQGLRHQVEQLSSSLKQKEQ---QLKEVAEKQEATRQDHAQQLATAAEEREASL 596

Query: 510  LLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLE 569
                  LK+L+A      +K K A K + L  +L    E   ++Q  + Q Q E+ EL  
Sbjct: 597  RERDAALKQLEAL-----EKEKAA-KLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650

Query: 570  DQRRMQEEQGQLQEELHRLTLPLPKSGLLLKS-QELLTKLEDLCELQLLYQGMQEEQKKL 628
                +Q      ++E H     + +  L L+S Q+  T+ E + +           +K  
Sbjct: 651  KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQ-----------EKDQ 699

Query: 629  IQNQDCVLKEQLEIH----EELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQ 684
            +Q Q   LKE L++     EE +R      +E      + K    S   ++K+ +  +E+
Sbjct: 700  LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759

Query: 685  MQA--------LQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPS 736
             +A        LQ + +A QA+ E+L++E    +  +   +++ +  ++E+   + +   
Sbjct: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819

Query: 737  IKMSLESYGKSYGSMVPS-NENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTS 795
             +     YG  +   + +  E C K      +  E            S S L+       
Sbjct: 820  SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKV------AGIESHSELQISRQQNE 873

Query: 796  ASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERF----EE 851
             +E +       +   +  K+      + D        + T +E A  E + R     +E
Sbjct: 874  LAELHAN--LARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931

Query: 852  MVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEK 911
               + L+K  A     +    +   L+EQ  +     +     L A ERE ++       
Sbjct: 932  TASRELVKEPA-----RAGDRQPEWLEEQQGRQFCSTQ---AALQAMEREAEQM------ 977

Query: 912  PMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKR 971
                    NE++ L+  L E Q Q Q    +Q R +    Q  G+ Q          EK 
Sbjct: 978  -------GNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQA-----DLALEKA 1025

Query: 972  PSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRK--SLEVVLYYKASQRK 1029
                 E R +NA  N  +       + +    ++    D E  K   LE     +  + +
Sbjct: 1026 ARAELEMRLQNA-LNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084

Query: 1030 --LDGLAKEEEKKEEMEEEKKQVKEEAK---EQCGDELVAEPADPEEAKSTEDQEENEED 1084
              +  L ++  KKE+        + EA    E  G +L A  A+  + +    +++ + D
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144

Query: 1085 KEEE--EKEEDSEEEEDDADSSLESPEENNPLRLSESKKS 1122
              E   E E  S  E D A  +L+   E     L  S+ +
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSA 1184



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 203/923 (21%), Positives = 374/923 (40%), Gaps = 156/923 (16%)

Query: 12   ALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSL-TETELEELRAQVLQLVA 70
            A  +E EE  +  ++++E+  + +K  + GS + ++  G +  T  +LE LRA+V +L  
Sbjct: 1075 AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQ 1134

Query: 71   ELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEH 130
            + ++ +E A     DSLE    LE ER + A++       ++ LQG+L            
Sbjct: 1135 QCQKQQEQA-----DSLERS--LEAERASRAERDSA----LETLQGQLE----------- 1172

Query: 131  EKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRG 190
            EK  EL   +  L  AQ E+ + R   +D    H       +  + R + E E    +  
Sbjct: 1173 EKAQELGHSQSALASAQRELAAFRTKVQD----HSKAEDEWKAQVARGRQEAERKNSLIS 1228

Query: 191  DYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRA----LQES 246
              E E++ L  ++  K  E      L       E+ Q+L ER   L  E  +      E 
Sbjct: 1229 SLEEEVSILNRQVLEKEGESKELKRL--VMAESEKSQKLEERLRLLQAETASNSARAAER 1286

Query: 247  NSSLTGQLADL--ESERTQRATERWLQSQTLSMTSAESQTSEMD-----FLEPDPEMQLL 299
            +S+L  ++  L  E+E+ + A+E   Q  T     AE    E+      F + +  +  L
Sbjct: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346

Query: 300  RQQLRDAE---EQMHGMKNKCQELCCE--LEELQHHRQVSEEEQRR--LQRELKCAQNEV 352
            + +    +    ++   K+ CQ+L  E    E +H  ++ + +Q    L+ EL  AQ E+
Sbjct: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL 1406

Query: 353  -----LRFQTSHSVTQNEELKS-------RLCTLQKKYDTSQDEQNEL----------LK 390
                 LR + +      ++L++       +L  L+K +    +E   L          L+
Sbjct: 1407 GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLE 1466

Query: 391  MQLQLQTE--LRQLKVMKST----LVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQ 444
            ++L    E  +++L  +++     L E Q E +   R  +L +        K K+LE +Q
Sbjct: 1467 VELDQAREKYVQELAAVRADAETRLAEVQREAQSTAR--ELEVMTAKYEGAKVKVLEERQ 1524

Query: 445  QLQEELQCHEAELQHL----RDTVASFKESNEK----DTETHAQLQEMKQLYQASKDELE 496
            + QEE Q   A+++ L    R+     +E ++K    D  +  Q Q++K +     +  +
Sbjct: 1525 RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQ 1584

Query: 497  RQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKE 556
              + +  QL +  L  QL  KE  A H                  ++ + +  Y A +++
Sbjct: 1585 EAQRLQAQLNE--LQAQLSQKEQAAEH---------------YKLQMEKAKTHYDAKKQQ 1627

Query: 557  MGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQL 616
              +LQ    E L    ++Q+E  +L+ E  RL   L ++GL  K  E   +        L
Sbjct: 1628 NQELQ----EQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCR-------HL 1676

Query: 617  LYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDS-KLAKSSKCNRN 675
              Q    E +    +Q      + ++  +  + +E   +  L+   DS  L+       +
Sbjct: 1677 TAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLS 1736

Query: 676  KQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSP 735
              SKL   Q     V    G+    + Q           RL   ++  LE +    + + 
Sbjct: 1737 ITSKLPRTQPDGTSV---PGEPASPISQ-----------RLPPKVE-SLESLYFTPIPAR 1781

Query: 736  S---IKMSLESYGKSYGSMVPSNENCRK----------TYDTTVDDNESYYKSYTSTQT- 781
            S   ++ SL+S G  +        + R+          T    V++ +S   S+ ST++ 
Sbjct: 1782 SQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSA 1841

Query: 782  -SSKSFLKSYDSSTS----ASEAYGKS-------YCTTSNSSITYKKSYGSTSSSDTCQK 829
             +S++ L++  S+ S     S  YG S       Y  T+ SS   +   G +S +   + 
Sbjct: 1842 PASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSS-ARRSQAGVSSGAPPGRN 1900

Query: 830  SFVSSCTDEEPAEPEDMERFEEM 852
            SF      +EP + +D  R  E+
Sbjct: 1901 SFYMGTCQDEPEQLDDWNRIAEL 1923


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  127 bits (319), Expect = 6e-29
 Identities = 234/1176 (19%), Positives = 478/1176 (40%), Gaps = 111/1176 (9%)

Query: 5    EGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQ 64
            E + L  +L EE+   EE ++E+E+ +   Q+      L  +    L   E +LEE + +
Sbjct: 91   EVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE 150

Query: 65   VLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLRE- 123
               +    +   + A Q   +  +++   ++ER       +  T+  ++L  E   +++ 
Sbjct: 151  NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL 210

Query: 124  EISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELE 183
            +  LL+     ++  +++EL     ++Q+L    ++   E E +   L+++  ++Q++  
Sbjct: 211  KTELLQRPGIEDVAVLKKEL----VQVQTL---MDNMTLERERESEKLKDECKKLQSQYA 263

Query: 184  DMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRAL 243
              E        E+A    E+ +   E       S  + L ++ Q L E      ++Y  L
Sbjct: 264  SSEATISQLRSELAKGPQEVAVYVQELQKL--KSSVNELTQKNQTLTENLLKKEQDYTKL 321

Query: 244  QESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQL 303
            +E ++  +    ++++   Q+  +       LS +        ++  E     Q L+++L
Sbjct: 322  EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL 381

Query: 304  RDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQ 363
             + E        K Q L  E ++LQ  R+  E+   +LQ E+    +++L  +       
Sbjct: 382  SEVE-------TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434

Query: 364  NEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQ 423
                + R  + +K  D  Q   +  LK+  +L+ +L++ KV  ST +++Q +K      +
Sbjct: 435  GRLKEQRQLSSEKLMDKEQQVADLQLKLS-RLEEQLKE-KVTNSTELQHQLDKTKQQHQE 492

Query: 424  KLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQE 483
            +  LQ         KL E Q  L++ L+    + Q +++  A  ++S E  +    + ++
Sbjct: 493  QQALQQSTTA----KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548

Query: 484  MKQLYQASKDE---LERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL 540
            +    QA + E   L + +     L++ +     +LK    SH   +         + L 
Sbjct: 549  LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ---------ENLH 599

Query: 541  SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK 600
             ++ E +   +A+Q  +  L+    EL       +E+  QL  ++   T  L  S    K
Sbjct: 600  DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT-ELLLSAEAAK 658

Query: 601  SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLEN 660
            + +       L   Q   Q  Q+E  K+    D V  +  +  E   +  ESH +E  E 
Sbjct: 659  TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQL-ESHLKEYKE- 716

Query: 661  PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADL 720
                K     +     + ++   +  +L+V     QA Q+L QQ Q     E +  +   
Sbjct: 717  ----KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772

Query: 721  QLCLEEMQLLQVQSPSIKMS--LESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTS 778
            QL +E+  +   +    K S  LES  +         +  ++ ++T   + +  ++   +
Sbjct: 773  QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832

Query: 779  TQTSSKSFLKSYDSSTSA--------SEAYGKSYCTTSNSSITYKK--SYGSTSSSD--- 825
               ++ + L+       A         +   K   +  NS   ++K    G  +  D   
Sbjct: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892

Query: 826  TCQ------KSFVSSCTDEEPAEPEDMERFEEMVVKVLIKL-----QAVQAMYQISQ--E 872
            TC+      +  + +   E+    + +E+ +E   ++ ++L     Q +QA   + Q  +
Sbjct: 893  TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952

Query: 873  EHSQLQEQMEKLLAKQKDLKEELDACEREFKECM---ECLEKPMAPQ--NDKNEIKELQT 927
            E  QLQ  + +L    +  K++++A + E K  +     LE  +  Q      E+   + 
Sbjct: 953  EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012

Query: 928  KLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANK-- 985
            K+  LQ  Y+ S +   +L       E +L   +++L+ + EK  S+ +E    N N+  
Sbjct: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL-SLAQEDLISNRNQIG 1071

Query: 986  NMNKNANGVKMKKVT-KPCSDTSESDLETR-KSLEVVLYYKASQRK-----LDGLAKEEE 1038
            N NK    +K  K T +  S   E  L+ R K+L+ +   K+ + K        LA+ EE
Sbjct: 1072 NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE 1131

Query: 1039 KKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAK-------------------STEDQE 1079
             K   E+E  ++ EE K     E + E  + ++AK                   + E ++
Sbjct: 1132 IKCRQEKEITKLNEELKSH-KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK 1190

Query: 1080 ENEE------DKEEEEKEEDSEEEEDDADSSLESPE 1109
             N++       KEEEE +++  E+E    S ++  E
Sbjct: 1191 RNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226



 Score =  120 bits (302), Expect = 6e-27
 Identities = 221/1012 (21%), Positives = 443/1012 (43%), Gaps = 139/1012 (13%)

Query: 13   LYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAEL 72
            L EE  E E + + ++ E +Q+Q+          +  GL        +L++++ QL ++L
Sbjct: 377  LKEELSEVETKYQHLKAEFKQLQQ-----QREEKEQHGL--------QLQSEINQLHSKL 423

Query: 73   EETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEK 132
             ET    G       E  G L+++R  S+++     +Q+  LQ +L  L E++     EK
Sbjct: 424  LETERQLG-------EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK----EK 472

Query: 133  ESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDY 192
             +   E++ +L   + + Q  +QA + S T      A L+E     QN+LE + R  GD 
Sbjct: 473  VTNSTELQHQLDKTKQQHQE-QQALQQSTT------AKLRE----AQNDLEQVLRQIGDK 521

Query: 193  EMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTG 252
            + +I +L A ++   S+ + SL   +   L  ++Q        LN+    LQE N +L  
Sbjct: 522  DQKIQNLEALLQ--KSKENISLLEKEREDLYAKIQAGEGETAVLNQ----LQEKNHTLQE 575

Query: 253  QLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHG 312
            Q+  L        TE+ L++Q+ S   A+    +        ++Q  +  LR A++++  
Sbjct: 576  QVTQL--------TEK-LKNQSESHKQAQENLHD--------QVQEQKAHLRAAQDRVLS 618

Query: 313  MKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLC 372
            ++    EL  +L E       S+E+  +L  ++K A+ E+L    +    Q  +L++ L 
Sbjct: 619  LETSVNELNSQLNE-------SKEKVSQLDIQIK-AKTELLLSAEAAKTAQRADLQNHLD 670

Query: 373  TLQKKYDTSQDEQNEL--------LKMQ------LQLQTELRQLKVMKSTLVENQSEKEL 418
            T Q      Q E N++         K+Q       QL++ L++ K  +  L   Q  +EL
Sbjct: 671  TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK--EKYLSLEQKTEEL 728

Query: 419  LCRLQKLHLQHQNVTCEKEKL---LERQQQLQEELQCHEAELQHLRDTVASFKESNEKDT 475
              +++KL      V   KE+    L++Q+QL  +L+    EL    +       S   D 
Sbjct: 729  EGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDL 788

Query: 476  ETHAQ-LQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKE-----LKASHPIPEDK 529
            +  ++ L+ +KQ     ++E +  K  ++ L Q+  +   EL       +     +  +K
Sbjct: 789  QKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEK 848

Query: 530  GKCANKCDTLLSRLTELQEKYKASQKEM-GQLQMEQCELLEDQRRMQEEQGQLQEELHRL 588
                 +  T+  +L+++ +  K S+ E   + Q  +  +L+ ++  +E + QLQ ++   
Sbjct: 849  EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN- 907

Query: 589  TLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHE---- 644
               L +   L KS E   + E   +L+L    MQE+   LIQ Q+ + + + E  +    
Sbjct: 908  --TLKEQKELKKSLE--KEKEASHQLKLELNSMQEQ---LIQAQNTLKQNEKEEQQLQGN 960

Query: 645  --ELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELL 702
              EL++  E   +++     + K+A   K     ++KL  +  QA Q +  A + K  +L
Sbjct: 961  INELKQSSEQKKKQIEALQGELKIAVLQK--TELENKLQQQLTQAAQEL-AAEKEKISVL 1017

Query: 703  QQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTY 762
            Q    +  E  K+LQ+D      E +LL  +   +K   E    +   ++ SN N     
Sbjct: 1018 QNNYEKSQETFKQLQSDFY--GRESELLATRQ-DLKSVEEKLSLAQEDLI-SNRNQIGNQ 1073

Query: 763  DTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTS 822
            +  + + ++     T  Q S+K   +       A +   K         +  K       
Sbjct: 1074 NKLIQELKT--AKATLEQDSAKK-EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE 1130

Query: 823  SSDTCQKSFVSSCTDEEPA-------EPEDMERFEEMVVKVLIKLQ--AVQAMYQISQEE 873
                 Q+  ++   +E  +       E  +++  ++++++  ++LQ  A      + QE+
Sbjct: 1131 EIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK 1190

Query: 874  HSQ--LQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMA-PQNDKNEIK------E 924
             +Q  L++Q++K   ++++LK+E    E+E K   E  EK +   ++++NE K       
Sbjct: 1191 RNQQILKDQVKK---EEEELKKEF--IEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245

Query: 925  LQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVK 976
            L   L  ++ ++Q+S      L    + L G++   +  ++  +++R ++++
Sbjct: 1246 LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLE 1297



 Score =  117 bits (292), Expect = 8e-26
 Identities = 202/978 (20%), Positives = 417/978 (42%), Gaps = 132/978 (13%)

Query: 17   EEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETR 76
            +E+ +   E++ ++E+QV           +    LS  E +L+E      +L  +L++T+
Sbjct: 438  KEQRQLSSEKLMDKEQQV----------ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487

Query: 77   ELAGQHEDDSLELQGLLEDERLASAQQAEVFTK------QIQQLQGELRSLREEISLLEH 130
            +   QH++     Q      R A     +V  +      +IQ L+  L+  +E ISLLE 
Sbjct: 488  Q---QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK 544

Query: 131  EKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRM-QNELEDMERIR 189
            E+E    ++  ++   + E   L Q  E + T  E  +  L E L    ++  +  E + 
Sbjct: 545  ERE----DLYAKIQAGEGETAVLNQLQEKNHTLQEQ-VTQLTEKLKNQSESHKQAQENLH 599

Query: 190  GDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQE---- 245
               + + A LRA  +   S  +        + L  +L E +E+   L+ + +A  E    
Sbjct: 600  DQVQEQKAHLRAAQDRVLSLETS------VNELNSQLNESKEKVSQLDIQIKAKTELLLS 653

Query: 246  SNSSLTGQLADLES--ERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQL 303
            + ++ T Q ADL++  +  Q A +   Q      T  +  T+++   +       L   L
Sbjct: 654  AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ--DKQEHCSQLESHL 711

Query: 304  RDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQ 363
            ++ +E+   ++ K +EL  ++++L+               E+K ++ + L+         
Sbjct: 712  KEYKEKYLSLEQKTEELEGQIKKLEAD-----------SLEVKASKEQALQ-DLQQQRQL 759

Query: 364  NEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCR-- 421
            N +L+ R   L K+ +    E+  +   +L LQ +   L+ +K  L + + EK++L +  
Sbjct: 760  NTDLELRATELSKQLEM---EKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF 816

Query: 422  ---LQKLHLQH-------QNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESN 471
                Q+  +QH       Q    E +K+   ++ L  EL   + +L  + D++ + K   
Sbjct: 817  ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF 876

Query: 472  EKDTET-HAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKG 530
            EK+ +   A + ++++  +  K +L+ Q  M + L++   L +   KE +ASH +  +  
Sbjct: 877  EKENQKGKAAILDLEKTCKELKHQLQVQ--MENTLKEQKELKKSLEKEKEASHQLKLE-- 932

Query: 531  KCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTL 590
                  +++  +L + Q   K ++KE  QLQ    EL +   + +++   LQ EL    L
Sbjct: 933  -----LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987

Query: 591  PLPK------SGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHE 644
               +        L   +QEL  + E +  LQ  Y+  QE  K+L  +      E L   +
Sbjct: 988  QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047

Query: 645  ELRRFKESHFQEVLENPDDSKLAKSSKC-NRNKQSKLLMEQMQALQVMYDAGQAKQELLQ 703
            +L+  +E      L    +  ++  ++  N+NK    L+++++  +   +   AK+E   
Sbjct: 1048 DLKSVEEK-----LSLAQEDLISNRNQIGNQNK----LIQELKTAKATLEQDSAKKEQQL 1098

Query: 704  QEQGRLLEE--RKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKT 761
            QE+ + L++  +++   + +L  E+ +L +++    +   E        +   NE  +  
Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE--------ITKLNEELKSH 1150

Query: 762  YDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGST 821
               ++ +  +  K         K  L+    S  A+    K         +  ++     
Sbjct: 1151 KLESIKEITNL-KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE----- 1204

Query: 822  SSSDTCQKSFV---SSCTDEEPAEPEDMERFEEMVVKVLIKLQA-------VQAMYQISQ 871
               +  +K F+   +    E   +   M++ EE   K+ +++ A       V+  +Q SQ
Sbjct: 1205 ---EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ 1261

Query: 872  EEHSQLQEQMEKLLAKQKDLKEELDACEREFKECME-CLEKPMAPQNDKNEIKELQTKLR 930
               S+L++Q + L  +   L+  +   + E +  +E CL+        + EI++LQTK+ 
Sbjct: 1262 RRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLK-------GEGEIEKLQTKVL 1314

Query: 931  ELQLQYQ---ASMDEQGR 945
            ELQ +     A++ E GR
Sbjct: 1315 ELQRKLDNTTAAVQELGR 1332



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 111/584 (19%), Positives = 252/584 (43%), Gaps = 59/584 (10%)

Query: 10   LPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLV 69
            L ++ ++  ++EEE++ ++++ E + +   +    +N    +  T TEL++++ +   L+
Sbjct: 795  LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR--IQTTVTELQKVKMEKEALM 852

Query: 70   AELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLE 129
             EL   ++   +  D     +   E E            K  ++L+ +L+   E     +
Sbjct: 853  TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ 912

Query: 130  HEKESELKEIEQELHLAQAEIQSLRQA---AEDSATEHESDIASLQEDLCRMQNELED-- 184
             E +  L++ ++  H  + E+ S+++    A+++  ++E +   LQ ++  ++   E   
Sbjct: 913  KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK 972

Query: 185  --MERIRGDYEMEIASL-RAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYR 241
              +E ++G  E++IA L + E+E K  +          +   +EL   +E+   L   Y 
Sbjct: 973  KQIEALQG--ELKIAVLQKTELENKLQQ--------QLTQAAQELAAEKEKISVLQNNYE 1022

Query: 242  ALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQ 301
              QE+   L       ESE      +     + LS+   +  ++       +  +Q L+ 
Sbjct: 1023 KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT 1082

Query: 302  QLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSV 361
                 E+     + + QE C  L+++Q  + + E+E   +  + K A+ E ++ +    +
Sbjct: 1083 AKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL--VNEKSKLAEIEEIKCRQEKEI 1140

Query: 362  TQ-NEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC 420
            T+ NEELKS      K+    +D +  L++ +L+LQ +   LK      VE +   + + 
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAA----VEQEKRNQQIL 1196

Query: 421  RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQ-HLRDTVASFKESNEKDTETHA 479
                           K+++ + +++L++E    EA+L   +++     K+  E + +   
Sbjct: 1197 ---------------KDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM 1241

Query: 480  QLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTL 539
            Q+  + +     K E +  +    +LE+     + E+  L+A+    +D+ +       L
Sbjct: 1242 QITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRA------L 1295

Query: 540  LSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQE 583
            L R            K  G+++  Q ++LE QR++      +QE
Sbjct: 1296 LERCL----------KGEGEIEKLQTKVLELQRKLDNTTAAVQE 1329



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 77/413 (18%), Positives = 164/413 (39%), Gaps = 68/413 (16%)

Query: 1    MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE 60
            ++A++GE+ +  L + E E + +++  +  +E   +   +  L  N  +     +    +
Sbjct: 975  IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD 1034

Query: 61   LRAQVLQLVA---ELEETRELAGQHEDDSLELQG-------LLEDERLASAQQAEVFTKQ 110
               +  +L+A   +L+   E     ++D +  +        L+++ + A A   +   K+
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK 1094

Query: 111  IQQLQGELRSLRE---EISLLEHE---KESELKEIEQELHLAQAEIQSLRQAAEDSATEH 164
             QQLQ   ++L++   E SL E E   ++S+L EIE+     + EI  L +  +    E 
Sbjct: 1095 EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154

Query: 165  ESDIASLQ------------------------EDLCRMQNELEDM-----ERIRGDYEME 195
              +I +L+                        E   R Q  L+D      E ++ ++  +
Sbjct: 1155 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEK 1214

Query: 196  IASLRAEME-----MKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSL 250
             A L +E++     MK  E + +      + L E L  +++ +         L++    L
Sbjct: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1274

Query: 251  TGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQM 310
             G++A LE+              T+     E +      L+ + E++ L+ ++ + + ++
Sbjct: 1275 RGEIAVLEA--------------TVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320

Query: 311  HGMKNKCQELCCELEELQ-HHRQVSEE---EQRRLQRELKCAQNEVLRFQTSH 359
                   QEL  E + LQ  H Q       E   +Q  + C +   +  +  H
Sbjct: 1321 DNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHH 1373


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score =  127 bits (318), Expect = 8e-29
 Identities = 220/1074 (20%), Positives = 453/1074 (42%), Gaps = 106/1074 (9%)

Query: 81   QHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIE 140
            Q +  + ++ GL E + +    +  +F +      G+  S +EE    +   +   K ++
Sbjct: 1349 QAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQ 1408

Query: 141  QELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLR 200
            +E  + + + +  ++  E   +E   ++A+L+E + + + +L  +ER     + + A   
Sbjct: 1409 KERKVGKIKREMTKE--ERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDE 1466

Query: 201  AEMEMKSSEPSGSLGLSDYSG--LQEELQELRERYHFLNEEYRALQESNSSLTGQLADLE 258
             +     +  S      ++    LQEE ++L +    L+ E   LQE           L+
Sbjct: 1467 WKQVHGETRKSWKAWKEEWEKRLLQEE-EKLHQAGEKLSPEEEMLQEDKK--------LK 1517

Query: 259  SERTQRATERWLQSQTLSMTSAESQTSEMD---FLEPDPEMQLLRQQLRDAEEQMHGMKN 315
             E  ++  E  L S++      + +   ++     E + + Q + ++ R  +E+    + 
Sbjct: 1518 WEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARI 1577

Query: 316  KCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQ 375
              +    E +  Q  R++++EE++  Q E + AQ E    Q    +TQ++   ++     
Sbjct: 1578 HRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKF 1637

Query: 376  KKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCE 435
             + + +  ++ E L  + +   + R+    K   V  + EK  L +      + +N+  +
Sbjct: 1638 AQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEK--LAKKGGKLAEVKNILAQ 1695

Query: 436  K-EKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDE 494
            K E+L +R+Q L  + +    EL+ L   +       E+  +   +L E K+     ++ 
Sbjct: 1696 KVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEA 1755

Query: 495  LERQKHMYDQLEQDL-----LLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEK 549
            L  Q+    + E  L     LL Q + K  +    +PE++ +   K + L+ +  +L +K
Sbjct: 1756 LAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQK 1815

Query: 550  YKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLE 609
             +     M +L   +  L + +   QE++   QE   +  L   K  LL   + L    +
Sbjct: 1816 RERWINSMEELTKNKMILYQKKNLAQEKKNLAQE---KEKLAQRKENLLYNKERLTHSKK 1872

Query: 610  DLCELQ----LLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSK 665
             L +++    +  + + + ++KL Q ++ V+K++ ++ E  ++         L   +DS 
Sbjct: 1873 QLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKK---------LVQVEDS- 1922

Query: 666  LAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLE 725
            LAK       KQ KL  E+M+               L  E+  +++ +KRL+ +L +  E
Sbjct: 1923 LAK-------KQEKLAQEKMK---------------LALEKA-MVQGKKRLRGELDIAKE 1959

Query: 726  EMQL-LQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSK 784
            E  L L+++  + +      GK   S   + E  R+   T V+      + +    +  +
Sbjct: 1960 EKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQ-----ELFERKLSLEE 2014

Query: 785  SFLKSYDSSTSASE---AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPA 841
              L   D   +  E   A GK   T         +   + +S    +K        +EPA
Sbjct: 2015 KILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKR---ESLSKEPA 2071

Query: 842  EPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEE---LDAC 898
            +          + K+L  LQ +    +   +E  ++ +    L  K++ L  E   LD  
Sbjct: 2072 K----------LNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIK 2121

Query: 899  EREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRL------LVVQEQ 952
            E +F E    L K       K   ++L  K+R +  + +   +E+ +L      +++ ++
Sbjct: 2122 EWDFSEKRSELTKDEKKLARKQ--RKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE 2179

Query: 953  LEGQLQCCQEELRQLREKRPSVVKEA-RGKNANKNMNKNANGVKMKKVTKPCSDTSESDL 1011
             EG ++  +EE+    ++R    KEA RG    +  +   + V+ ++      ++   +L
Sbjct: 2180 EEGGIE--EEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDEL 2237

Query: 1012 ETRKSL----EVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPA 1067
            E ++SL    E     +  + + +   +EEE+KEE E E+KQV++E +E+   +   E  
Sbjct: 2238 EKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEK--KKKKKEKK 2295

Query: 1068 DPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKK 1121
              E  +  E  EE EE   EEE E  S+EEE++   SLE   +     L + K+
Sbjct: 2296 KEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQ 2349



 Score =  117 bits (293), Expect = 6e-26
 Identities = 212/994 (21%), Positives = 411/994 (41%), Gaps = 115/994 (11%)

Query: 15   EEEEEEEEEEEEVEEEEEQV--QKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAEL 72
            +EE +  EE EE+   EE+V  Q+G  V        +       E +++  +  +     
Sbjct: 1422 KEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAW 1481

Query: 73   EETRELAGQHEDDSLELQG---------LLEDERLASAQQAEVF-------TKQIQQLQG 116
            +E  E     E++ L   G         L ED++L   +  +V+       +K+ Q    
Sbjct: 1482 KEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE 1541

Query: 117  ELRSLREEISLLEHEKESELKEIE---QELHLAQAEIQSLRQAAEDSATEHESDIASLQE 173
            E  +L EE+S    EKE ++ E +   QE H   A I   R  AE    + E  +A  +E
Sbjct: 1542 EEVTLEEEVSREGEEKEQQVTEEQRHIQEEH-KWARIHRKRARAEKKRAQEERKLAQEEE 1600

Query: 174  DLCRMQNELEDMERIRGDYEMEIASLRAEM---EMKSSEPSGSLGLSDYSGLQEELQELR 230
             L + + +L   ER      ++I     EM   E K ++   +L       L +E ++L 
Sbjct: 1601 KLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRG-EKLSQEAEKLA 1659

Query: 231  ERYHFLNEEYRALQESNSSLT---GQLADLESERTQRATERWLQSQTLSMTSAESQTSEM 287
            ++   L +++  +      L    G+LA++++   Q+  E   + Q L     E    E+
Sbjct: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE-LAQEL 1718

Query: 288  DFLEPD-PEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELK 346
            + LE D  E+    ++L   E ++   K K  E   E E L   R+   EE      E K
Sbjct: 1719 EELEWDMEELSWKEEELNQEEGKLVEEKKKLAE---EEEALAWQREKLSEE------ETK 1769

Query: 347  CAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQL-QTELRQLKVM 405
             AQ E L  Q    + Q++E       + ++ +    ++ +L++ +++L Q   R +  M
Sbjct: 1770 LAQEEELLIQEKEKLAQHKE------KMPEEEERLGRKREQLIEKKMKLAQKRERWINSM 1823

Query: 406  KSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQL---QEELQCHEAELQHLRD 462
            +    E    K +L + + L  + +N+  EKEKL +R++ L   +E L   + +L  +++
Sbjct: 1824 E----ELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKN 1879

Query: 463  TVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKAS 522
             +  F   N+   +   +L + K+     K++L   +    Q+E  L   Q +L + K  
Sbjct: 1880 KLGMF---NKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMK 1936

Query: 523  HPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRM-------- 574
              +  +K     K    L    ++ ++ KA   EM +L  E+  L+E +  +        
Sbjct: 1937 --LALEKAMVQGK--KRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPET 1992

Query: 575  --QEEQGQLQEELHRLTLPLPKSGLLLKSQELLT---------KLEDLCELQLLYQG--- 620
              Q +  Q+++EL    L L +  +LL    +L          KLE     ++  QG   
Sbjct: 1993 SRQRKMTQVEQELFERKLSLEEK-ILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRK 2051

Query: 621  MQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKL 680
            + +  +KLI+ ++ + KE  ++++ L+  ++    E     ++ K+ K  +    K+ +L
Sbjct: 2052 LAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRL 2111

Query: 681  LMEQMQALQVMYDAGQAKQELLQQEQGRLLEERK-------RLQADLQLCLEEMQLLQVQ 733
             +EQ +     +D  + + EL + E+    ++RK        +  + ++  EE +L +  
Sbjct: 2112 SIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKH 2171

Query: 734  SPSIKMSLESYGKSYGSMVP-SNENCRKTYDTTVDDN-ESYYKSYTSTQTSSKSFLKSYD 791
            S  I    E  G     ++P      RK  +    D  +  + S      S + F +  +
Sbjct: 2172 SEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEME 2231

Query: 792  SSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEE 851
            S     E                     S SS +  ++       +EE  E E+  + EE
Sbjct: 2232 SLLDELE------------------KQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273

Query: 852  MVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEK 911
               +  ++ +  +   +  +++  ++QE+ E    K++ + EE    E E     E  E+
Sbjct: 2274 EGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEE----ETESLSDEEEEEE 2329

Query: 912  PMAPQNDKNEIKELQTKLRELQLQYQASMDEQGR 945
              + + + +  KE+  K ++ +LQ Q     +GR
Sbjct: 2330 SCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGR 2363



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 110/543 (20%), Positives = 239/543 (44%), Gaps = 66/543 (12%)

Query: 13   LYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELR---------- 62
            LY+++   +E++   +E+E+  Q+  +   L  NK R L+ ++ +L +++          
Sbjct: 1833 LYQKKNLAQEKKNLAQEKEKLAQRKEN---LLYNKER-LTHSKKQLVQVKNKLGMFNKIL 1888

Query: 63   AQVLQLVAELEET----RELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGEL 118
            AQV + + + +ET    +E   + E   ++++  L  ++   AQ+      +   +QG+ 
Sbjct: 1889 AQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKK 1948

Query: 119  RSLREEISLLEHEK--ESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLC 176
            R LR E+ + + EK    E+K + +E  +   E +      E   T  +  +  ++++L 
Sbjct: 1949 R-LRGELDIAKEEKALNLEMKRLAEE-KMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006

Query: 177  RMQNELEDM-----ERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRE 231
              +  LE+      +RI    E EIA  + ++E    +     G    +    +L + RE
Sbjct: 2007 ERKLSLEEKILLHEDRILAMEESEIA--KGKLEFTRGQRIFVQGQRKLAKASRKLIKKRE 2064

Query: 232  RYHF----LNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEM 287
                    LN+  +ALQ+       +L   E + T+     +++ + LS+  ++    E 
Sbjct: 2065 SLSKEPAKLNKILKALQKLTRD-ERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEW 2123

Query: 288  DFLEPDPEM-----QLLRQQLRDAEEQMHGMKNKCQELCCELEEL--QHHRQVSEEEQ-- 338
            DF E   E+     +L R+Q R    +M  M NK +++  E  +L  +H   + ++E+  
Sbjct: 2124 DFSEKRSELTKDEKKLARKQ-RKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEG 2182

Query: 339  ------------RRLQRELKCAQNEVLRFQTSHSVTQ-------NEELKSRLCTLQKKYD 379
                        RR ++  +  + +  + + S  V +       +EE++S L  L+K+  
Sbjct: 2183 GIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQES 2242

Query: 380  TSQDEQNELLKMQLQLQTELRQLKVMKSTLVEN---QSEKELLCRLQKLHLQHQNVTCEK 436
             S +E+ E  + + + + E+R+ +  +    E    Q EKE   + +K   + +    EK
Sbjct: 2243 LSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEK 2302

Query: 437  EKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELE 496
            E++ E ++++  E +      +   +   S +E  +++ E   + ++ K   Q  K    
Sbjct: 2303 EEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRG 2362

Query: 497  RQK 499
            R++
Sbjct: 2363 RER 2365



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 36/143 (25%), Positives = 67/143 (46%), Gaps = 23/143 (16%)

Query: 12   ALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAE 71
            +L  EEEEE EEEEE EEEE + ++                  E   EE   +  Q+  E
Sbjct: 2242 SLSSEEEEEREEEEEREEEEVREEE------------------EERKEEEEGEEKQVEKE 2283

Query: 72   LEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHE 131
             EE ++   + + + ++ +  + +E+     + E  +   ++ + E  SL EE+     +
Sbjct: 2284 EEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEV-----D 2338

Query: 132  KESELKEIEQELHLAQAEIQSLR 154
            +E E+ + E++  L +   +SLR
Sbjct: 2339 REKEILKKEKQFKLQEQRRKSLR 2361


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  126 bits (317), Expect = 1e-28
 Identities = 228/1128 (20%), Positives = 468/1128 (41%), Gaps = 128/1128 (11%)

Query: 55   ETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQL 114
            +  L++   + +    EL E  +     ED+  +LQ  +E  R    +Q     KQ+   
Sbjct: 149  KANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDAT 208

Query: 115  QGELRS----LREEISLLEHEKESELKEIEQEL----HLAQAEIQSLRQAAEDSATEHES 166
              E +     L+  I       +  +  +++EL     + Q E++ L    E SA EHE+
Sbjct: 209  TDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEA 268

Query: 167  DIASLQEDLCRMQNELEDMER-IRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEE 225
            +I  L E    +  + E  E+ I+  YE E+ +LR          + S    D       
Sbjct: 269  EINKLNELKENLVKQCEASEKNIQKKYECELENLRK---------ATSNANQDNQICSIL 319

Query: 226  LQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTS 285
            LQE       +NE+ + L+++   L  Q + L+ E T      ++ +  L +   ++Q  
Sbjct: 320  LQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVT------YMNNLKLKL-EMDAQHI 372

Query: 286  EMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQ--------ELCCELEELQHHRQVSEEE 337
            + +F     +++    +L  A+E+   +  K +        + C  +E  QH+R+V   +
Sbjct: 373  KDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVE--QHNREVQSLK 430

Query: 338  QRRLQRELKCAQNEVLRFQTSHSVT---QNEELKSRLCTLQKKYDTSQDEQNELLKMQLQ 394
            ++  Q+E+       L       +T   + + LK +   LQ++   +      L ++   
Sbjct: 431  EQH-QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEI 489

Query: 395  LQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQ---EELQ 451
            LQTEL +     S   E+  +++    + +L  + +    EK+ LLE   +LQ   E+L 
Sbjct: 490  LQTELGESAGKISQEFESMKQQQA-SDVHELQQKLRTAFTEKDALLETVNRLQGENEKLL 548

Query: 452  CHEAELQHLRDTVASFKESN--------EKDTETHAQLQEMKQLYQASKDELERQKHMYD 503
              +  +  L +T+ + +E N        ++DT       ++  L +   D + + K+ ++
Sbjct: 549  SQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHE 608

Query: 504  QLEQDLLLCQLELKEL----KASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQ 559
            +++     C+ E + +    K      +   +   K + L   L E  ++   + +++ +
Sbjct: 609  EMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK 668

Query: 560  LQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSG----LLLKSQELLTKLEDLCELQ 615
            L ++   L ED+  +  E   L EE ++L+    +      + L  +E +   E + +L+
Sbjct: 669  LMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLE 728

Query: 616  LLYQGMQEEQ---KKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKC 672
               Q M EEQ    KL++N+     ++L +  +L  F +    EV E+ ++  +    + 
Sbjct: 729  KKLQLMVEEQDNLNKLLENEQV---QKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQA 785

Query: 673  NRNKQSKLLMEQMQ-ALQVMYDAGQAKQEL--LQQEQGRLLEERKRLQADLQLCLEEMQL 729
                 +K+  E+   A Q      + ++E+  LQ+E     EE K L  D +   +E  L
Sbjct: 786  VGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYE---QEKVL 842

Query: 730  LQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSS---KSF 786
            L+ +   I+   E+       M  +NE  R      +   E   ++ + ++  +   K F
Sbjct: 843  LRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCF 902

Query: 787  LKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDM 846
            +K +++     E   K         I  K S   + S      S V    ++     ++ 
Sbjct: 903  IKEHENLKPLLEQ--KELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC 960

Query: 847  ERFEEMVVKVLIKLQAVQAMYQIS---------QEEHSQLQEQMEKLLAKQKDLKEELDA 897
            +  EE + K  IKL AV+A  ++          +EE   L+ + ++L A  +DL +  ++
Sbjct: 961  KEKEEKINK--IKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES 1018

Query: 898  CER---EFKECMECL--EKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQ 952
             +    E+++  E L  EK  A  N ++ I++L  +LR   LQ +    +   LL   E 
Sbjct: 1019 YKNLLLEYEKQSEQLDVEKERA-NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077

Query: 953  LEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLE 1012
            L+   +  + ++ +++  +  V KE   +   K         K+K+     ++  E  ++
Sbjct: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQ-------KIKEHATTVNELEELQVQ 1130

Query: 1013 TRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQC--------GDELVA 1064
                                L KE+++ ++  +E + VK++A++           + L+ 
Sbjct: 1131 --------------------LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMK 1170

Query: 1065 EPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENN 1112
            E       K+ + ++  +E K +++K+E  +EE     SS++  EE N
Sbjct: 1171 ELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKN 1218



 Score =  114 bits (285), Expect = 5e-25
 Identities = 231/1058 (21%), Positives = 447/1058 (42%), Gaps = 180/1058 (17%)

Query: 105  EVFTKQIQQLQGEL-RSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATE 163
            E+ +K + +  G++ ++L E +  L  EK     E EQ+    + E   ++Q  EDS T+
Sbjct: 57   ELRSKPVTEGTGDIIKALTERLDALLLEKA----ETEQQCLSLKKENIKMKQEVEDSVTK 112

Query: 164  HESDIASLQEDLCRMQNELEDMER----IRGDYEMEIASLRAEMEMKSS---EPSGSLGL 216
                   L++       E+E+++     +R  Y  + A+L+ ++E   +   E S  L  
Sbjct: 113  MGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKF 172

Query: 217  SDYS-----GLQEELQELR----ERYHFLNEEYRALQESNSSLTGQLADLESERTQRATE 267
             + S      LQEE++++R    E+  +L ++  A  +       QL ++    +Q   +
Sbjct: 173  QNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQK 232

Query: 268  --RWLQSQTLSMTSAESQ-------TSEMDFLEPDPEMQLLRQQLRDAEEQMHGM-KNKC 317
                LQ + L + +   +         E    E + E+  L +   +  +Q     KN  
Sbjct: 233  NINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQ 292

Query: 318  QELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKK 377
            ++  CELE L+  +  S   Q      +   +N  +    +  V   + L+  L  L+ +
Sbjct: 293  KKYECELENLR--KATSNANQDNQICSILLQENTFVEQVVNEKV---KHLEDTLKELESQ 347

Query: 378  YDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE-LLCRLQKLHLQHQNVTCEK 436
            +   +DE   +  ++L+L+ + + +K       E   E+E L  ++ +L L  +   C  
Sbjct: 348  HSILKDEVTYMNNLKLKLEMDAQHIK------DEFFHEREDLEFKINELLLAKEEQGCVI 401

Query: 437  EKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKD----TETHAQLQEMKQLYQASK 492
            EKL      L ++  C+  E QH R+ V S KE ++K+     ET     E ++L    +
Sbjct: 402  EKLKSELAGLNKQF-CYTVE-QHNRE-VQSLKEQHQKEISELNETFLSDSEKEKLTLMFE 458

Query: 493  DE-LERQKHMYDQLEQDLLLCQLELKELK--ASHPIPEDKGKCANKCDTL----LSRLTE 545
             + L+ Q     Q +Q+ +L    L+E+       + E  GK + + +++     S + E
Sbjct: 459  IQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHE 518

Query: 546  LQEKYKASQKE-------MGQLQMEQCELLEDQRRMQEEQG---QLQEELHRLTLPLPKS 595
            LQ+K + +  E       + +LQ E  +LL  Q  + E +     LQE+     L L + 
Sbjct: 519  LQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQR 578

Query: 596  GLLLKSQE----LLTKLED--LCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRF 649
              +LK  E     LT+ +D  + +L+  ++ M    KK  + +  +L+   ++ + ++  
Sbjct: 579  DTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYN 638

Query: 650  KESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRL 709
             E   Q+V E     +     K   +++ + LM QM+ L    +   A+ + L +E  +L
Sbjct: 639  SELE-QKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKL 697

Query: 710  LEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDN 769
              E+K+L  DL     E+ L Q +   +K  +    K    MV   +N  K       +N
Sbjct: 698  SSEKKQLSRDL-----EVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL-----EN 747

Query: 770  ESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQK 829
            E   K +  TQ                   YG            + K  GS  S D+ +K
Sbjct: 748  EQVQKLFVKTQ------------------LYG------------FLKEMGSEVSEDSEEK 777

Query: 830  SFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAV-QAMYQISQEEHSQLQEQMEKLLAKQ 888
              V+                          LQAV +++ +I++E+ +   ++ EK+L  +
Sbjct: 778  DVVN-------------------------VLQAVGESLAKINEEKCNLAFQRDEKVLELE 812

Query: 889  KDLK----------EELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQA 938
            K++K          EEL +  R++++    L K +  +  ++E + LQ+ L E++   + 
Sbjct: 813  KEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKEL--EEIQSEKEALQSDLLEMKNANEK 870

Query: 939  SMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKK 998
            +  E   LL+  E++     C + E+    EK    +KE      ++N+           
Sbjct: 871  TRLENQNLLIQVEEV--SQTCSKSEIH--NEKEKCFIKE------HENL----------- 909

Query: 999  VTKPCSDTSESDLETRKSLEVVL---YYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAK 1055
              KP  +  + +L  R++  ++L     K+   K D L+  +E +E++E  +K+ KE+ +
Sbjct: 910  --KPLLE--QKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEE 965

Query: 1056 EQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEED 1093
            +    +LVA  A  E   S ++ +  +E+ E    E+D
Sbjct: 966  KINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD 1003



 Score =  110 bits (274), Expect = 1e-23
 Identities = 238/1151 (20%), Positives = 487/1151 (42%), Gaps = 164/1151 (14%)

Query: 8    VLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQ 67
            V L +L + +   +E E ++    E+  K   +  L  N H  +     + E     +L+
Sbjct: 570  VYLLSLSQRDTMLKELEGKINSLTEE--KDDFINKLK-NSHEEMDNFHKKCEREERLILE 626

Query: 68   LVAELEETRELAGQHEDDSLELQGLLE---------DERLASAQ-QAEVFTKQIQQLQGE 117
            L  ++E+T +   + E    EL G LE         D++L     Q +V ++  + L  E
Sbjct: 627  LGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAE 686

Query: 118  LRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCR 177
            ++SL EE + L  EK+   +++  E+ L+Q E   L+        EH   I  L++ L  
Sbjct: 687  VKSLYEENNKLSSEKKQLSRDL--EVFLSQKEDVILK--------EH---ITQLEKKLQL 733

Query: 178  MQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQE---ELQELRERYH 234
            M  E +++ ++  + +++   ++ ++               Y  L+E   E+ E  E   
Sbjct: 734  MVEEQDNLNKLLENEQVQKLFVKTQL---------------YGFLKEMGSEVSEDSEEKD 778

Query: 235  FLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDP 294
             +N   +A+ ES + +  +  +L  +R ++  E   + + L   S               
Sbjct: 779  VVN-VLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESV-------------V 824

Query: 295  EMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLR 354
            + + L+  LRD E++   ++        ELEE+Q  ++  + +   ++       NE  R
Sbjct: 825  QCEELKSLLRDYEQEKVLLRK-------ELEEIQSEKEALQSDLLEMKN-----ANEKTR 872

Query: 355  FQTSHSVTQNEEL-----KSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTL 409
             +  + + Q EE+     KS +   ++K    + E  + L  Q +L+    +L ++K +L
Sbjct: 873  LENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSL 932

Query: 410  VENQSEK-ELLCRLQKLHLQHQNV--TC-EKEKLLERQQ----QLQEELQCHEAELQHLR 461
             ++ S K + L  +++L  + +N+   C EKE+ + + +    + ++EL     E Q ++
Sbjct: 933  AKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVK 992

Query: 462  DTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKA 521
            + + S +  +EKD +  A ++++ Q  ++ K+ L   +   +QL+ +      + +    
Sbjct: 993  EELESLR--SEKD-QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVE------KERANNF 1043

Query: 522  SHPIPEDKGKCAN---KCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQ 578
             H I +   +  N   +C+T+ S   +L  + +  Q     L++   ++LE QR      
Sbjct: 1044 EHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEV---QILEVQRAKAMVD 1100

Query: 579  GQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKE 638
             +L+ E         K     K +E  T + +L ELQ+  Q  +++ +K +Q  + V K+
Sbjct: 1101 KELEAE---------KLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKD 1151

Query: 639  -------QLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVM 691
                    +EI +  R  KE + +   +N     L +  K  + KQ + L E++ +LQ  
Sbjct: 1152 AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ-ETLQEEITSLQSS 1210

Query: 692  YDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQV----QSPSIKMSLESYGKS 747
                + K   ++Q    LL + K+  AD +    +  +LQ     +  + +  +E Y   
Sbjct: 1211 VQQYEEKNTKIKQ----LLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQ 1266

Query: 748  YGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTT 807
               +        +   T+ + ++    +Y    T+ +   ++  +  +   +  +SY   
Sbjct: 1267 LAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVR 1326

Query: 808  SNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMY 867
             ++ +  +K+   + +              E     ++ E  E ++ ++ IKLQ  Q   
Sbjct: 1327 VHNVLKQQKNKSMSQA--------------ETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372

Query: 868  QISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKE--CMECLEKPMAPQNDKNEIKEL 925
            QI+  E   LQ + + LL +   + +E  + E E +E  C    E  M        + +L
Sbjct: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQL 1432

Query: 926  QTKLRELQLQYQ---ASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK---RPSVVKEAR 979
             ++   L+  ++     + E+ R  V  E L+ QL   + +L QL+ +   R  V  +  
Sbjct: 1433 TSQNEVLRNSFRDQVRHLQEEHRKTV--ETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQS 1490

Query: 980  GKNANKNMNKNANGVKMKKVTKPCSDTSE-SDLET-------RKSLEVVLYYKASQRKLD 1031
             KN  +  N +   + M  VT+   +  E +D E+        +SLE +L   + + KL+
Sbjct: 1491 LKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLL--NSPETKLE 1548

Query: 1032 -GLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEK 1090
              L   E  KEE+ ++     + A    G  L+ E     EA +    E+ +  K E  +
Sbjct: 1549 PPLWHAEFTKEELVQKLSSTTKSADHLNG--LLRE----TEATNAILMEQIKLLKSEIRR 1602

Query: 1091 EEDSEEEEDDA 1101
             E ++E E  A
Sbjct: 1603 LERNQEREKSA 1613


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  125 bits (313), Expect = 3e-28
 Identities = 197/880 (22%), Positives = 372/880 (42%), Gaps = 115/880 (13%)

Query: 15   EEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQ------- 67
            E  EE E E   +E+E E +QK  +   ++  K   L    +ELE    ++ +       
Sbjct: 625  ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684

Query: 68   LVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISL 127
            L  +LE   +   Q ++++LEL+  +E  + AS + A++  +  ++L+ E   L++ + L
Sbjct: 685  LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN-KELESEKEQLKKGLEL 743

Query: 128  LE--HEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDM 185
            L+   +K   L+   Q L +    +Q   + +     + ES++  L+ +   +Q  LE  
Sbjct: 744  LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE-- 801

Query: 186  ERIRGDYEMEIASLRAEM---EMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRA 242
                   E++I+S R E    E KS E   S    D   L++E + LR++    +     
Sbjct: 802  -------ELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD---TT 851

Query: 243  LQESNSSLTGQLADLESERTQRATERWLQSQT-LSMTSAESQTSEM--DFLEPDPEMQLL 299
            L+E+N     ++ +LE E    + E  +  ++ + +   E +  E+          +  L
Sbjct: 852  LEENNV----KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEE-------LQHHRQVSEEEQRRLQR--------- 343
            R+ L   + +   M N  ++L  ELE+       L H  Q +++  + L+          
Sbjct: 908  REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS 967

Query: 344  -ELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELL------------- 389
             E+K  +   L  +   S   N++L+  L T++K Y+  +  Q+E               
Sbjct: 968  LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1027

Query: 390  KMQLQLQTELRQLKVMKSTLVE-------NQSEKELL-CRLQKLHLQHQNVTCEKEKLLE 441
            K + + Q   R+L  +K  L+E        Q+EK+ L  +L++L  Q+ N+  +   L  
Sbjct: 1028 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1087

Query: 442  RQQQLQEE---LQCHEAELQHLRDTVASFKES-NEKDTETHAQLQEMKQLYQASKDELER 497
            +   LQE+   LQ   A+LQ    T+ S   S   ++ +   Q   ++   ++   E E 
Sbjct: 1088 QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERED 1147

Query: 498  QKHMYDQLEQDLLLCQLELKELKAS--HPIPEDKGKCANKCDTLLSRLTELQEKYKASQK 555
             K +YD L +D    +L L E +AS    +    G   +    L     +L+++Y    K
Sbjct: 1148 LKSLYDSLIKDHEKLEL-LHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLK 1206

Query: 556  EMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQ 615
            + GQL     E LE   ++++E+  L+ + H  T+      L  ++  L      L +  
Sbjct: 1207 QKGQL-----EDLEKMLKVEQEKMLLENKNHE-TVAAEYKKLCGENDRLNHTYSQLLKET 1260

Query: 616  LLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENP---DDSKLAKSSKC 672
             + Q   +  K L+ N      EQ  +  E  + KE + Q  + +    +  +L    K 
Sbjct: 1261 EVLQTDHKNLKSLLNNSKL---EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1317

Query: 673  NRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQV 732
            N  ++++ L++Q+Q L +        + LL+Q     +E +     + +  ++++  L+ 
Sbjct: 1318 NLEEENRHLLDQIQTLMLQ------NRTLLEQN----MESKDLFHVEQRQYIDKLNELRR 1367

Query: 733  QSPSIKMSLESYGKSYGSMVPSNE------NCRKTYDTTVDDNESYYKSYTSTQT---SS 783
            Q   ++  +    K Y    P           RK   +  D N    KS T T T   SS
Sbjct: 1368 QKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSS 1427

Query: 784  KSFLK-----SYDSSTSASEAY--GKSYCTTSNSSITYKK 816
            + FL+     S DSS+  S +   G++  T  +S +  K+
Sbjct: 1428 EGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKR 1467



 Score =  111 bits (277), Expect = 5e-24
 Identities = 182/853 (21%), Positives = 346/853 (40%), Gaps = 137/853 (16%)

Query: 20   EEEEEEEVEEEEEQVQK--GGSVGSLSVNKHRGL-----SLTETELEELRAQVLQLVAEL 72
            E E+     E  E  QK  G  V  L+ ++   L     SLT+T +EELR  V  +    
Sbjct: 432  ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT-VEELRTTVDSVEGNA 490

Query: 73   EETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEK 132
             +  ++  +++  S +++ +LE+E +   Q  +      + L  E   L + I  L    
Sbjct: 491  SKILKMEKENQRLSKKVE-ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS 549

Query: 133  ESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIAS----LQEDLCRMQNELEDMERI 188
            E ++K +EQE       + SLRQ ++ SA     DI      L E +    ++L  +E  
Sbjct: 550  ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFE 609

Query: 189  RGDYEMEIASLR--------AEMEMKSSEPSGSLGLSDYSGLQ---EELQELRERYHFLN 237
            +   + E+   +         E E+   E    L     + L+   E+++ L +    L 
Sbjct: 610  KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE 669

Query: 238  EEYRALQ---ESNSSLTGQLADLESERTQRATER------------------WLQSQTLS 276
             E R L+   +S  +LT QL  LE E +Q   E                    LQ +   
Sbjct: 670  RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729

Query: 277  MTSAESQTS----------------EMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQEL 320
            + S + Q                  E+ +   D E Q L++ L ++ +++  ++++ Q+L
Sbjct: 730  LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789

Query: 321  CCE-----------------LEELQHHRQVSEEEQRRLQRELKC--AQNEVLRFQTSHSV 361
              E                 LE+L+   +  E+E  +L+++ K    +N+ LR Q     
Sbjct: 790  EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849

Query: 362  TQNEELKSRLCTLQKKYDTSQDE--------------QNELLKMQLQLQTELRQLKVMKS 407
            T  EE   ++  L+K+  T   E              + E  ++  +   +++ L  ++ 
Sbjct: 850  TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909

Query: 408  TLV-ENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVAS 466
             LV E    +++   L+KL  + + +   KE+LL  +Q   +  +  E++L+        
Sbjct: 910  DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLE 969

Query: 467  FKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIP 526
             KE  EK     A+L+E     Q  + EL+  K  Y+ L+Q     Q E + +++S PI 
Sbjct: 970  IKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR----QDEERMVQSSPPIS 1023

Query: 527  EDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEE-- 584
             +  K   +       L +++++    ++    LQ E+  L    ++++ +   LQ +  
Sbjct: 1024 GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1083

Query: 585  -LHRLTLPLPKSGLLLKSQELLTKLEDLC----ELQLLYQGMQ--EEQKKLIQNQDCVLK 637
             L R T+ L +    L++Q    ++E+         L+ Q  Q   +Q  L    + V+K
Sbjct: 1084 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1143

Query: 638  EQLEI----------HEELRRFKE---SHFQEVLENPDDSKLAKSS-----KCNRNKQSK 679
            E+ ++          HE+L    E   S ++ ++      K A  +     +   ++ ++
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203

Query: 680  LLME--QMQALQVMYDAGQAK-------QELLQQEQGRLLEERKRLQADLQLCLEEMQLL 730
            LL +  Q++ L+ M    Q K        E +  E  +L  E  RL       L+E ++L
Sbjct: 1204 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1263

Query: 731  QVQSPSIKMSLES 743
            Q    ++K  L +
Sbjct: 1264 QTDHKNLKSLLNN 1276



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 196/991 (19%), Positives = 409/991 (41%), Gaps = 102/991 (10%)

Query: 150  IQSLRQAAEDSATEHESDIASLQEDLCRMQ-NELEDMERIRGDYEMEIASLRAEMEMKSS 208
            IQ L    + +   H  ++   QE++  +Q  E+ DM +   D E  + ++   ++    
Sbjct: 145  IQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQ--EDIEPLLKNMALHLKRLID 202

Query: 209  EPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATER 268
            E        ++S    EL E R+  HFL         ++SS          +RT+     
Sbjct: 203  ERD------EHSETIIELSEERDGLHFL-------PHASSSAQSPCGSPGMKRTE----- 244

Query: 269  WLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQ 328
                Q LS+  A+++           +++ LRQ+L +  EQ+   K + +++  EL+ LQ
Sbjct: 245  --SRQHLSVELADAKA----------KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQ 292

Query: 329  HHRQ--VSEEEQRRLQR-ELKCAQNEVLRFQTSHS-VTQNEELKSRLCTLQKKYDTSQDE 384
                  +S+    R+ R EL   + + +R     S V++ +E    +   + + +  +++
Sbjct: 293  QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352

Query: 385  QNELLKMQLQLQTELRQLKVMKSTLVENQSEK-ELLCRLQKLHLQHQNVTCEKEKLLERQ 443
               LL+ +  L+ +L   +     L E + E  +L  +L  + ++      + E+L+E  
Sbjct: 353  NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412

Query: 444  QQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQL-QEMKQLYQASKDELERQKHMY 502
              L+   +    E  HL   +     ++E        L  E+ +L  +   +LE +    
Sbjct: 413  MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472

Query: 503  DQLEQDLLLCQLELKELKASHPIPEDK--GKCANKCDTLLSRLTELQEKYKASQKEMGQL 560
             +  ++ L   ++  E  AS  +  +K   + + K + L + + + ++  +  Q     L
Sbjct: 473  TKTVEE-LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531

Query: 561  QMEQCEL---LEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQ-ELLTKLEDL-CELQ 615
              E+ +L   +E  R   E Q ++ E+ +   L    S L  +SQ     +++D+  E +
Sbjct: 532  MKEKAQLEKTIETLRENSERQIKILEQENE-HLNQTVSSLRQRSQISAEARVKDIEKENK 590

Query: 616  LLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKE-SHFQEVLENPDDSKLAKSSKCNR 674
            +L++ ++E   KL +    +  E+ +I +EL  +KE     E LEN            + 
Sbjct: 591  ILHESIKETSSKLSK----IEFEKRQIKKELEHYKEKGERAEELEN---------ELHHL 637

Query: 675  NKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQS 734
             K+++LL +++  L++  +    K E L+QE   L  E ++L+  L              
Sbjct: 638  EKENELLQKKITNLKITCE----KIEALEQENSELERENRKLKKTLD-----------SF 682

Query: 735  PSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSST 794
             ++   LES  K    +   N   R+     V+  +         Q  +K      +   
Sbjct: 683  KNLTFQLESLEKENSQLDEENLELRR----NVESLKCASMKMAQLQLENKELESEKEQLK 738

Query: 795  SASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPE--DMERFEEM 852
               E    S+  T    ++Y+   G    +   QK+  +S    +  E E  D+E   + 
Sbjct: 739  KGLELLKASFKKTERLEVSYQ---GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795

Query: 853  VVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKP 912
            + K L +L+      +  ++E+  L+++  +L   +K L++E     +  ++  E  +  
Sbjct: 796  LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE----NKRLRQQAEIKDTT 851

Query: 913  MAPQNDK--NEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
            +   N K  N  KE +T  +E+ +  ++ +    RL  ++++ +  ++    +++ L   
Sbjct: 852  LEENNVKIGNLEKENKTLSKEIGIYKESCV----RLKELEKENKELVKRATIDIKTLVTL 907

Query: 971  RPSVVKE-ARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETR-KSLEVVL---YYKA 1025
            R  +V E  + +  N ++ K  + ++   + K      E   + R K LE  L     K+
Sbjct: 908  REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS 967

Query: 1026 SQRKLDGLAKEEEKKEEMEEEKKQVKEEAKE-QCGDELVAEPADPEEAKSTEDQEENEED 1084
             + K + +A  E + EE     +Q+++E K  +   E + +  D E    +      E++
Sbjct: 968  LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1027

Query: 1085 KEEEEKEEDSEEEEDDADSSLESPEENNPLR 1115
            K E E +E + E     D  +E    N  L+
Sbjct: 1028 KWERESQETTRELLKVKDRLIEVERNNATLQ 1058


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  123 bits (308), Expect = 1e-27
 Identities = 238/1123 (21%), Positives = 464/1123 (41%), Gaps = 185/1123 (16%)

Query: 12   ALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAE 71
            A ++   + + E E++    + + K   +  L     R LS    +  EL      L  E
Sbjct: 112  ASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLR-RMERSLSSYRGKYSELVTAYQMLQRE 170

Query: 72   LEETRELAGQHEDDSL----ELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISL 127
             ++ + +  Q +D SL    EL+  L+ ++ A     E F   +++    +  L+ ++SL
Sbjct: 171  KKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSL 230

Query: 128  LEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMER 187
            L+    +    ++    L Q E Q+     E++    ESD   + ED   ++      +R
Sbjct: 231  LKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENP---ESDGEPVVEDGTSVKTLETLQQR 287

Query: 188  IRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESN 247
            ++          R E  +K  +              E +Q  +E+   L  E  ALQE  
Sbjct: 288  VK----------RQENLLKRCK--------------ETIQSHKEQCTLLTSEKEALQEQ- 322

Query: 248  SSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQL------LRQ 301
              L  +L +LE  +     E+     T  +T      + ++ LE D  M +      + +
Sbjct: 323  --LDERLQELEKIKDLHMAEK-----TKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHE 375

Query: 302  QLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSV 361
             L   EE++  ++++ +++  + EEL   R+  E+ +R    EL+ A +   + + +   
Sbjct: 376  TLEMKEEEIAQLRSRIKQMTTQGEEL---REQKEKSERAAFEELEKALSTAQKTEEARRK 432

Query: 362  TQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCR 421
             +  E+  ++ T++K   TS++E+       + LQ EL ++K     +++  SE+++  +
Sbjct: 433  LK-AEMDEQIKTIEK---TSEEER-------ISLQQELSRVKQEVVDVMKKSSEEQI-AK 480

Query: 422  LQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQL 481
            LQKLH        EKE L  ++Q+L ++LQ  E E Q         K + EK    + ++
Sbjct: 481  LQKLH--------EKE-LARKEQELTKKLQTREREFQE------QMKVALEKSQSEYLKI 525

Query: 482  -QEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL 540
             QE +Q    + +ELE QK         L   + +L++L+              + +T  
Sbjct: 526  SQEKEQQESLALEELELQKKAI------LTESENKLRDLQ-------------QEAETYR 566

Query: 541  SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK 600
            +R+ EL+   + S +E      +    LE ++    ++  +  E H+  L        LK
Sbjct: 567  TRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELES------LK 620

Query: 601  SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEE-LRRFKESHFQEVLE 659
             Q+     E   +LQ+L Q  Q E +KL        +E+ E  +E L + KE  FQ  +E
Sbjct: 621  HQQDALWTE---KLQVLKQQYQTEMEKL--------REKCEQEKETLLKDKEIIFQAHIE 669

Query: 660  NPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQAD 719
              ++  L K                        D  Q + E L  E   +L+ R +L+  
Sbjct: 670  EMNEKTLEK-----------------------LDVKQTELESLSSELSEVLKARHKLE-- 704

Query: 720  LQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTST 779
                 EE+ +L+ Q+  +K  LE+       M     + ++  D+ + ++E    S   T
Sbjct: 705  -----EELSVLKDQTDKMKQELEA------KMDEQKNHHQQQVDSIIKEHEV---SIQRT 750

Query: 780  QTSSKSFLKSYDSSTSASEAYGKSY-CTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDE 838
            + + K  +   +      + + K +     N     K+S G    +      F S     
Sbjct: 751  EKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSY---- 806

Query: 839  EPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDAC 898
            + A  E  + +EE + ++  KL  ++        E   L +Q+ ++ A++KD+  ELDA 
Sbjct: 807  QSATHEQTKAYEEQLAQLQQKLLDLET-------ERILLTKQVAEVEAQKKDVCTELDAH 859

Query: 899  EREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQ------ 952
            + + ++ M+ LEK  +    K  +K L T++ E +L+      EQ + ++V+++      
Sbjct: 860  KIQVQDLMQQLEKQNSEMEQK--VKSL-TQVYESKLEDGNKEQEQTKQILVEKENMILQM 916

Query: 953  LEGQLQCCQEELRQLREKRPSV-----VKEARGKNANKNMNKNANGVK-MKKVTKPCSDT 1006
             EGQ +  +   ++L  K  S+       E + KN  K M K     K M++  K     
Sbjct: 917  REGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK--KKL 974

Query: 1007 SESDLETRKSLE---VVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELV 1063
             + + + +K LE   + L  K  Q     L   +     + +   +++   KEQ      
Sbjct: 975  LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034

Query: 1064 AEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLE 1106
                +  +  S  +++ N++ +E +E  E   +E++   + L+
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELK 1077



 Score =  111 bits (277), Expect = 5e-24
 Identities = 245/1178 (20%), Positives = 485/1178 (41%), Gaps = 183/1178 (15%)

Query: 15   EEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAEL-- 72
            E+  E+ E+E+E   +++++     +  ++      L + +TELE L +++ +++     
Sbjct: 643  EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK 702

Query: 73   --EETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQ----IQQLQGELRSLREEIS 126
              EE   L  Q +    EL+  +++++    QQ +   K+    IQ+ +  L+    ++ 
Sbjct: 703  LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762

Query: 127  LLEHEKESELKEIEQELHLAQAEIQ----SLRQAAE--------DSATEHESDIASLQED 174
            LL  E++  LKE +  +   +A+I+     L+QA+          SAT  ++   + +E 
Sbjct: 763  LLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT--KAYEEQ 820

Query: 175  LCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSE-PSGSLGLSD-YSGLQEELQELRER 232
            L ++Q +L D+E  R     ++A + A+ +   +E  +  + + D    L+++  E+ ++
Sbjct: 821  LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQK 880

Query: 233  YHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEP 292
               L + Y +  E  +         E E+T++     ++ + + +   E Q         
Sbjct: 881  VKSLTQVYESKLEDGNK--------EQEQTKQIL---VEKENMILQMREGQKK------- 922

Query: 293  DPEMQLLRQQLRDAEEQMHGMKNKCQ-ELCCELEELQHHRQVSEEEQRRLQRELKCAQNE 351
              E+++L Q+L   E+ +H +  + + +   + ++++  +Q ++E Q  L+++L      
Sbjct: 923  --EIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKL------ 974

Query: 352  VLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVE 411
                     + Q  +LK  L       + SQ E+    KM    Q     +    S L  
Sbjct: 975  ---------LDQEAKLKKEL--ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023

Query: 412  NQSEKELLCRLQKLHLQHQN--VTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKE 469
            NQ  KE +  L ++H +  N  ++  ++KL ++ ++LQE    HE +LQ     VA  K 
Sbjct: 1024 NQ--KEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE---IHEIQLQEKEQEVAELK- 1077

Query: 470  SNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASH--PIPE 527
              +K      + +EM +     K+E  +Q    ++L++ L        + K++H   + +
Sbjct: 1078 --QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL--------KQKSAHVNSLAQ 1127

Query: 528  DKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELL----EDQRRMQEEQGQLQ- 582
            D+ K       L + L +L+     S KE   LQ +  EL     ED+R++ E   +L+ 
Sbjct: 1128 DETK-------LKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKT 1180

Query: 583  --EELHRLTLPLPKSGLLLKSQEL-LTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQ 639
              EE   L     KS   L+ + L   KL +   +QL     + E     +  + +    
Sbjct: 1181 TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISS 1240

Query: 640  LEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNR-NKQSKLLMEQMQALQVMYDAGQAK 698
             + +  L R   SH Q       ++ L K+   +    Q + L E+   L + +   QA 
Sbjct: 1241 SKTNAILSRI--SHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQ--QAT 1296

Query: 699  QELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENC 758
             +L ++E      + K ++AD++  + E + LQ +           G +        E+C
Sbjct: 1297 HQLEEKE-----NQIKSMKADIESLVTEKEALQKE-----------GGNQQQAASEKESC 1340

Query: 759  RKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSY 818
                   + +N        +  T  K  LK      S+             +SI+  +  
Sbjct: 1341 ITQLKKELSEN-------INAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKE 1393

Query: 819  GSTSS------SDTCQ-------KSF-VSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQ 864
             + SS       + C+        SF V + + E+ +  E ++ +     +   K Q+  
Sbjct: 1394 AAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRF 1453

Query: 865  AMYQISQEEHSQLQEQMEKLLAKQKD-----LKEELDACEREFKECMECLEKPMAPQNDK 919
              +Q + +E  Q+Q +++   A +KD     LKEELD   + F    +CL+  M     K
Sbjct: 1454 TQHQNTVKE-LQIQLELKSKEAYEKDEQINLLKEELDQQNKRF----DCLKGEMEDDKSK 1508

Query: 920  NEIKE--LQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEE-------------- 963
             E KE  L+T+L+    +     D   +  +  E L   L+   ++              
Sbjct: 1509 MEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQH 1568

Query: 964  LRQLREKRPSVVKEARGK---NANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVV 1020
             ++L E++ + VKEA  K     N+  +  A     KK  +  + + +S  E  K+LE  
Sbjct: 1569 FQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDR 1628

Query: 1021 LYYKASQRKLDGLAKEEEK-----------KEEMEEEKKQVKEEAKEQCGDELVAEPAD- 1068
            L  +++ +  +   K E+K            EE EE+ K+  E    +   +L     + 
Sbjct: 1629 LESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREV 1688

Query: 1069 ---PEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADS 1103
                E+ KS E  +          K   +  E+++ADS
Sbjct: 1689 HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726



 Score =  107 bits (267), Expect = 7e-23
 Identities = 189/963 (19%), Positives = 401/963 (41%), Gaps = 146/963 (15%)

Query: 108  TKQIQQLQGELRSLREEISLLE----------HEKESELKEIEQELHLAQAEIQSLRQAA 157
            T  + +L+ +LR L EE + L            EKE+++K ++ ++     E ++L++  
Sbjct: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEG 1327

Query: 158  ---EDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSL 214
               + +A+E ES I  L+++L    N +  M+    + ++EI+SL  ++   + +   S+
Sbjct: 1328 GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387

Query: 215  GLSDYSGL--------QEELQELRERYHFLNEEYRALQESNSSLTGQLADLE---SERTQ 263
             LS+             EE  EL ++   L+ +   L +   S   Q+ D     SE  +
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK 1447

Query: 264  RATERWLQSQ-TLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCC 322
            +A  R+ Q Q T+     + +    +  E D ++ LL+++L    ++   +K        
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKG------- 1500

Query: 323  ELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQ 382
               E++  +   E+++  L+ ELK     ++  +  H   +  E++S L  + K Y+  +
Sbjct: 1501 ---EMEDDKSKMEKKESNLETELKSQTARIMELE-DHITQKTIEIES-LNEVLKNYNQQK 1555

Query: 383  DEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLER 442
            D +++ L  +LQ     ++L   K   V+   EK L    Q   ++ +  T +KE     
Sbjct: 1556 DIEHKELVQKLQ---HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKEL---- 1608

Query: 443  QQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMY 502
             + +   ++  E EL+ L D + S         E+ A+L E+K+  +     +++Q    
Sbjct: 1609 -EHVNLSVKSKEEELKALEDRLES---------ESAAKLAELKRKAEQKIAAIKKQ---- 1654

Query: 503  DQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQM 562
                   LL Q+E KE        + K    +    L ++L E + +    ++++  ++ 
Sbjct: 1655 -------LLSQMEEKE-------EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700

Query: 563  EQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKS-QELLTKLE-DLCELQLLYQG 620
             Q E L   R  +      ++E           G + K+ +E ++ L+ +L E + L Q 
Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQE------EADSQGCVQKTYEEKISVLQRNLTEKEKLLQR 1754

Query: 621  MQEEQKKLIQNQ---DCVLKEQLEI--HEELRRFKES----HFQEVLENPDDSKLAKSSK 671
            + +E+++ + +     C  +E+L    H E ++ ++     H QE LE            
Sbjct: 1755 VGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE----------- 1803

Query: 672  CNRNKQSKLLMEQMQALQVMYDAGQAKQEL--LQQEQGRLLEERKRLQADLQLCLEEMQL 729
              +NK+  L++ Q    +   +  QAKQ L  +  +  + L+E++     L+  ++E+  
Sbjct: 1804 --KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861

Query: 730  LQVQSPSI-KMSLESYGKSYGSM--VPSNENCRKTYDTTVDDNESYYKSY-------TST 779
              V+   + ++ +E     Y  +  +   +   K  +   ++ E   KS+       ++ 
Sbjct: 1862 CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNM 1921

Query: 780  QTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEE 839
            +            +    +  GK            +K +      +  +K +     ++ 
Sbjct: 1922 EAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEH--QQELEILKKEYDQEREEKI 1979

Query: 840  PAEPEDMERFEEMVVKVLIK---LQAVQAMYQI----------SQEEHSQL----QEQME 882
              E ED+E      +K L++    Q  Q   ++          +QE  ++L    QE+  
Sbjct: 1980 KQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETN 2039

Query: 883  KLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDE 942
            +LL K  +  ++L    + ++E ++  E+ M  +     +++LQT+L ELQ +YQ  +++
Sbjct: 2040 QLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAK-----VRDLQTQLEELQKKYQQKLEQ 2094

Query: 943  QGR-------LLVVQEQLEGQLQCCQEELRQLREKRPSVVK-EARGKNANKNMNKNANGV 994
            +         ++ +Q QL  +     +   + +E R  +   E R K   KN+     G 
Sbjct: 2095 EENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGT 2154

Query: 995  KMK 997
              K
Sbjct: 2155 PYK 2157



 Score =  102 bits (253), Expect = 3e-21
 Identities = 234/1180 (19%), Positives = 473/1180 (40%), Gaps = 173/1180 (14%)

Query: 10   LPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLV 69
            L  +YE + E+  +E+E + ++  V+K   +          L + E + +E+     +L 
Sbjct: 884  LTQVYESKLEDGNKEQE-QTKQILVEKENMI----------LQMREGQKKEIEILTQKLS 932

Query: 70   AELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLE 129
            A+ +    L  ++E      +  +E  +  + +  E   K++   + +L+   E  +L  
Sbjct: 933  AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALEL 992

Query: 130  HEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQE---------------D 174
             +KE +     + L +AQA    +  A     T  +  I SL E                
Sbjct: 993  SQKEKQFNA--KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK 1050

Query: 175  LCRMQNELEDMERIR-GDYEMEIASLRAEMEM---KSSEPSGSLGLSDYSGLQEE--LQE 228
            L +   EL+++  I+  + E E+A L+ ++ +   +  E +  +      G++++  L E
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110

Query: 229  LRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMD 288
            L+E+    +    +L +  + L   L  LE +  +   E          T  + Q  E+ 
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN---------TFLQEQLVELK 1161

Query: 289  FLEPDPEMQL--LRQQLRDAEEQMHGMKNKCQELCCELEELQ-HHRQVSEEEQ------- 338
             L  + + ++  L  +L+  +E+   +K+  ++    LE+     +++SEE         
Sbjct: 1162 MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICC 1221

Query: 339  RRLQRELKCAQNEVLRFQTS-------------HSVTQ-NEELKSRLCT---LQKKYDTS 381
            ++ +  L+   NE++   +S             H  T+  E L  + CT   L+ +    
Sbjct: 1222 KKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL 1281

Query: 382  QDEQNEL----LKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKE 437
             +EQN L     +   QL+ +  Q+K MK+ +    +EKE L   QK     Q    EKE
Sbjct: 1282 TEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---QKEGGNQQQAASEKE 1338

Query: 438  KLLER-QQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELE 496
              + + +++L E +       + L++        +++ T+ + QLQ    L +  +  + 
Sbjct: 1339 SCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSE-KEAAIS 1397

Query: 497  RQKHMYDQLEQDLL---------LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTE-- 545
              +  YD+ + +LL         +  L  +++ A   + +   K +       SR T+  
Sbjct: 1398 SLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQ 1457

Query: 546  ---------LQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSG 596
                     L+ K K + ++  Q+ + + EL +  +R    +G+++++  ++        
Sbjct: 1458 NTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLE 1517

Query: 597  LLLKSQEL-LTKLED-LCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHF 654
              LKSQ   + +LED + +  +  + + E  K   Q +D   KE ++        K  HF
Sbjct: 1518 TELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ--------KLQHF 1569

Query: 655  QEVLENPDD------------SKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELL 702
            QE+ E  D+                 S K     + K L     +++   +  +A ++ L
Sbjct: 1570 QELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRL 1629

Query: 703  QQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTY 762
            + E    L E KR +A+ ++   + QLL      ++   E Y K   S +       +  
Sbjct: 1630 ESESAAKLAELKR-KAEQKIAAIKKQLLS----QMEEKEEQYKKGTESHLSELNTKLQER 1684

Query: 763  DTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSI--TYKKSYGS 820
            +  V   E   KS  S+Q+ +    +S  +      AY +     S   +  TY++    
Sbjct: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVA----AYTEQEEADSQGCVQKTYEEKISV 1740

Query: 821  TSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQ 880
               + T ++  +     E+               + LIKL+  +A     Q     LQE+
Sbjct: 1741 LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800

Query: 881  MEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQA-- 938
            +E     +K+ K  L   +   KE  +      A QN +N   ++Q  L+E +L  Q   
Sbjct: 1801 LE-----EKNKKYSLIVAQHVEKEGGK--NNIQAKQNLENVFDDVQKTLQEKELTCQILE 1853

Query: 939  -SMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMK 997
              + E    LV Q+++    +   EEL    EK  ++ ++  G+N    +          
Sbjct: 1854 QKIKELDSCLVRQKEVH---RVEMEELTSKYEKLQAL-QQMDGRNKPTEL---------- 1899

Query: 998  KVTKPCSDTSESDLETRKSLE-VVLYYKASQRKLDGLAKEEEK--KE--EMEEEKKQVKE 1052
             + +   + S+S L   K L  +   +   + KL G  +E++K  KE   ++++ + +++
Sbjct: 1900 -LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958

Query: 1053 EAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEE 1092
            E +++            E  K   DQE  E+ K+E+E  E
Sbjct: 1959 EHQQEL-----------EILKKEYDQEREEKIKQEQEDLE 1987



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 233/1193 (19%), Positives = 467/1193 (39%), Gaps = 170/1193 (14%)

Query: 31   EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRE--LAGQHEDDSLE 88
            E + QK      L  +K +   L + +LE+  +++ Q V  L +  E  L   +++    
Sbjct: 844  EVEAQKKDVCTELDAHKIQVQDLMQ-QLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQT 902

Query: 89   LQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQA 148
             Q L+E E +   Q  E   K+I+ L  +L +  + I +L  E E++ K  E+++   + 
Sbjct: 903  KQILVEKENMI-LQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ 961

Query: 149  EIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSS 208
            + + +++  +    + E   A L+++L     EL   E+      +E+A           
Sbjct: 962  KAKEMQETLKKKLLDQE---AKLKKELENTALELSQKEKQFNAKMLEMAQ---------- 1008

Query: 209  EPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATER 268
              + S G+SD     E  Q  +E+   L E +R       S+  +  + ++E  Q   E 
Sbjct: 1009 --ANSAGISDAVSRLETNQ--KEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEI 1064

Query: 269  WLQSQTLSMTSA-----------ESQTSEMDFLEP-----DPEMQLLRQQLRDAEEQMHG 312
             LQ +   +              E    E+ +L+      D  +  L++QL+     ++ 
Sbjct: 1065 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS 1124

Query: 313  MKNKCQELCCELEELQHHRQVSEEEQRRLQR---ELKCAQNEVLRFQ---TSHSVTQNEE 366
            +     +L   LE+L+     S +E   LQ    ELK    E  R     TS   T +EE
Sbjct: 1125 LAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEE 1184

Query: 367  LKSRLCTLQKKYDTSQDEQNELLKMQLQLQTEL--------RQLKVMKSTLVENQSEKEL 418
             +S   + +K   + +D+  E  K+  +L  +L          L+   + L+   S K  
Sbjct: 1185 FQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTN 1244

Query: 419  LCRLQKLHLQHQNV---------TCEKEKLLERQQQLQEE-------LQCHEAELQHLRD 462
                +  H QH+           TC   +L  + +QL EE        Q    +L+   +
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304

Query: 463  TVASFKESNEK-DTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKA 521
             + S K   E   TE  A  +E     QA+ ++      +  +L +++    L  +ELK 
Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364

Query: 522  SHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQL 581
                     K     +  L     L EK  A      Q   E+CELL+  + +  +   L
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424

Query: 582  QEE---------------------------LHRLTLPLPKSGLLLKSQELLTKLEDLCEL 614
             +E                            H+ T+   +  L LKS+E   K E   ++
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDE---QI 1481

Query: 615  QLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENP-------DDSKLA 667
             LL + + ++ K+     DC LK ++E  +     KES+ +  L++        +D    
Sbjct: 1482 NLLKEELDQQNKRF----DC-LKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536

Query: 668  KSSKC--------NRNKQSKL-LMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKR--- 715
            K+ +         N N+Q  +   E +Q LQ   + G+ K   +++ + ++L    +   
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYS 1596

Query: 716  LQADLQLCLEEMQLLQVQSPSIKMSLESY-----GKSYGSMVPSNENC-------RKTYD 763
            ++A+L+   +E++ + +   S +  L++       +S   +              +K   
Sbjct: 1597 MKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLL 1656

Query: 764  TTVDDNESYYKSYTSTQTSS-KSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTS 822
            + +++ E  YK  T +  S   + L+  +      E   KS  ++ + ++   +S  +  
Sbjct: 1657 SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKN-- 1714

Query: 823  SSDTCQKSFVSSCTDEEPAEPED--MERFEEMVVKVLIKLQAVQAMYQ-ISQEEHSQLQE 879
                     V++ T++E A+ +    + +EE +  +   L   + + Q + QE+   +  
Sbjct: 1715 ---------VAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSS 1765

Query: 880  QMEKLLAKQKDL--KEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRE-LQLQY 936
              E     Q+ L   E  +A + E +  +  L++ +  +N K  +   Q   +E  +   
Sbjct: 1766 HFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI 1825

Query: 937  QASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKM 996
            QA  + +     VQ+ L+ +   CQ   ++++E    +V++           K  + V+M
Sbjct: 1826 QAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQ-----------KEVHRVEM 1874

Query: 997  KKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVK----- 1051
            +++T              ++    L  + ++ K      + +    ME +   ++     
Sbjct: 1875 EELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934

Query: 1052 -EEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKE-EEEKEEDSEEEEDDAD 1102
             E  K++ G E+V    D    +    QE     KE ++E+EE  ++E++D +
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLE 1987



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 165/776 (21%), Positives = 313/776 (40%), Gaps = 139/776 (17%)

Query: 436  KEKLLERQQQLQEELQCHEAELQ-----HLRDTVASFKESNEK--------DTETHAQ-- 480
            K+K+ E QQQLQ+ L   +A         +R   +SF E  ++        DT++ AQ  
Sbjct: 6    KQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKL 65

Query: 481  ---LQEMKQLYQAS-KDELER--QKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCA- 533
               +  ++ L+++  K+ L R   K    +      L +L+L    AS   P D    A 
Sbjct: 66   QLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAE 125

Query: 534  ---NKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTL 590
                  D+L     +L ++ +  ++ +   + +  EL+   + +Q E+ +LQ        
Sbjct: 126  DLVGNSDSL--NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQ-------- 175

Query: 591  PLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKE------------ 638
                 G+L +SQ+    L  + EL+   Q  Q+ +K L +  D  L+E            
Sbjct: 176  -----GILSQSQD--KSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQV 228

Query: 639  ---------------------QLEIHEEL---RRFKESHFQEVLENPDDSKLAKSSKCNR 674
                                 QLE   E+       ES  + V+E+    K  ++ +   
Sbjct: 229  SLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV 288

Query: 675  NKQSKLL---MEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQ 731
             +Q  LL    E +Q+ +       +++E LQ++    L+E ++++    L + E   L 
Sbjct: 289  KRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK---DLHMAEKTKLI 345

Query: 732  VQSPSIKMSLESYGKSYGSMVPSNENCRKTYDT--TVDDNESYYKSYTSTQTSSKSFLKS 789
             Q    K  +E   +  G ++   E  R+ ++T    ++  +  +S     T+    L+ 
Sbjct: 346  TQLRDAKNLIEQLEQDKGMVIA--ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELRE 403

Query: 790  Y--DSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDME 847
                S  +A E   K+  T   +    +K     +  D   K+   +  +E  +  +++ 
Sbjct: 404  QKEKSERAAFEELEKALSTAQKTEEARRK---LKAEMDEQIKTIEKTSEEERISLQQELS 460

Query: 848  RFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLA-KQKDLKEELDACEREFKECM 906
            R         +K + V  M + S+E+ ++LQ+  EK LA K+++L ++L   EREF+E M
Sbjct: 461  R---------VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM 511

Query: 907  E-CLEKPMAPQNDKNEIKELQTK--LRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEE 963
            +  LEK  +     ++ KE Q    L EL+LQ +A + E    L     L+ + +  +  
Sbjct: 512  KVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKL---RDLQQEAETYRTR 568

Query: 964  LRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLY- 1022
            + +L       ++E + ++ +  ++  A   K  K      +  +++LE+ K  +  L+ 
Sbjct: 569  ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628

Query: 1023 ---------YKASQRKLDGLAKEEEKK-------------EEMEE---EKKQVKEEAKEQ 1057
                     Y+    KL    ++E++              EEM E   EK  VK+   E 
Sbjct: 629  EKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELES 688

Query: 1058 CGDE----LVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPE 1109
               E    L A     EE    +DQ +  + + E + +E     +   DS ++  E
Sbjct: 689  LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE 744



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 146/709 (20%), Positives = 295/709 (41%), Gaps = 98/709 (13%)

Query: 4    MEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRA 63
            +E + L+  L   +E  EE++  V+E EE++       +L    +   +  ET+ +EL  
Sbjct: 1557 IEHKELVQKLQHFQELGEEKDNRVKEAEEKIL------TLENQVYSMKAELETKKKELEH 1610

Query: 64   QVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLRE 123
              L + ++ EE + L  + E +S     L E +R A  + A +  + + Q++ +    ++
Sbjct: 1611 VNLSVKSKEEELKALEDRLESESAAK--LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK 1668

Query: 124  EISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSA------------TE-------- 163
                   E  ++L+E E+E+H+ + +++S+  +  ++             TE        
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728

Query: 164  -----HESDIASLQEDLCRMQNEL-----EDMERIRGDYEMEIASLRAEMEMKSSEPSGS 213
                 +E  I+ LQ +L   +  L     E  E +   +EM        ++++ +E    
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQH 1788

Query: 214  LGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQ 273
               S    LQEEL+E  ++Y  +  ++   +   +++    A    E      ++ LQ +
Sbjct: 1789 EDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQ---AKQNLENVFDDVQKTLQEK 1845

Query: 274  TLSMTSAESQTSEMDFL--------EPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELE 325
             L+    E +  E+D            + E    + +   A +QM G +NK  EL   LE
Sbjct: 1846 ELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDG-RNKPTEL---LE 1901

Query: 326  ELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQ 385
            E    +  S   Q +L   ++ AQ+  L F+ + +  + ++L   +  LQK     + E 
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNME-AQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEH 1960

Query: 386  NELLKMQLQLQTELRQLKVMKS----TLVENQSEKELLCRLQ-KLHLQHQNVTCEKEKLL 440
             + L++  +   + R+ K+ +      L  N + K+L+     +L  + Q +    ++ +
Sbjct: 1961 QQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETI 2020

Query: 441  ERQQQLQEE-LQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDEL-ERQ 498
             + Q+++ E L+ H+ E   L   +A      EKD +     +  +++  A ++E+  + 
Sbjct: 2021 NKAQEVEAELLESHQEETNQLLKKIA------EKDDDLKRTAKRYEEILDAREEEMTAKV 2074

Query: 499  KHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMG 558
            + +  QLE+     Q + ++       P +      +  T L++ T L    K  ++E  
Sbjct: 2075 RDLQTQLEE----LQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEF- 2129

Query: 559  QLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLP-KSGLLLKSQELL----TKLEDLCE 613
                EQ   LED+ +  E      + ++  T+  P K G L  +   L    T+ E L +
Sbjct: 2130 ---REQIHNLEDRLKKYE------KNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRK 2180

Query: 614  LQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPD 662
            +   Y  M  E K + +    VLK           F +   Q++LE  D
Sbjct: 2181 VLFEYM-MGRETKTMAKVITTVLK-----------FPDDQTQKILERED 2217



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 63/293 (21%), Positives = 129/293 (44%), Gaps = 18/293 (6%)

Query: 844  EDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKD---LKEELDACER 900
            E+ E   E VV+    ++ ++ + Q  + + + L+   E + + ++    L  E +A + 
Sbjct: 262  ENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQE 321

Query: 901  EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLV-VQEQLEGQLQC 959
            +  E ++ LEK         E  +L T+LR+ +   +    ++G ++   + Q+   L+ 
Sbjct: 322  QLDERLQELEK--IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEM 379

Query: 960  CQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSES--DLETRKSL 1017
             +EE+ QLR +   +  +       K  ++ A   +++K       T E+   L+     
Sbjct: 380  KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 439

Query: 1018 EVVLYYKASQRKLDGLAKEEEK-KEEMEEEKKQVKEE--AKEQ--CGDELVAEPADPEEA 1072
            ++    K S+ +   L +E  + K+E+ +  K+  EE  AK Q     EL  +  +  + 
Sbjct: 440  QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK 499

Query: 1073 KSTEDQEENEEDKEEEEKEED-----SEEEEDDADSSLESPEENNPLRLSESK 1120
              T ++E  E+ K   EK +      S+E+E     +LE  E      L+ES+
Sbjct: 500  LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESE 552



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 105/510 (20%), Positives = 206/510 (40%), Gaps = 62/510 (12%)

Query: 621  MQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKL 680
            M  E + L+ N D + KEQL   + LRR +                 +S    R K S+L
Sbjct: 120  MDSEAEDLVGNSDSLNKEQLI--QRLRRME-----------------RSLSSYRGKYSEL 160

Query: 681  LMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMS 740
            +     A Q++    +  Q +L Q Q + L     L+ +LQ+  +  + LQ +  +   S
Sbjct: 161  VT----AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDA---S 213

Query: 741  LESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAY 800
            LE   + Y S++ +  +  K        N    K     +  ++ F K  +  +      
Sbjct: 214  LEEKDQ-YISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVV 272

Query: 801  --GKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLI 858
              G S  T        K+            +S    CT        + E  +E + + L 
Sbjct: 273  EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCT----LLTSEKEALQEQLDERLQ 328

Query: 859  KLQAVQAMYQISQEEH-SQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQN 917
            +L+ ++ ++   + +  +QL++    +   ++D    +   +R+  E +E  E+ +A   
Sbjct: 329  ELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL- 387

Query: 918  DKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKE 977
             ++ IK++ T+  EL+ Q + S  E+       E+LE  L   Q+             +E
Sbjct: 388  -RSRIKQMTTQGEELREQKEKS--ERAAF----EELEKALSTAQK------------TEE 428

Query: 978  ARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEE 1037
            AR K     M++    ++  K ++    + + +L   K   V +  K+S+ ++  L K  
Sbjct: 429  ARRK-LKAEMDEQIKTIE--KTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLH 485

Query: 1038 EK----KEEMEEEKKQVKE-EAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEE 1092
            EK    KE+   +K Q +E E +EQ    L    ++  +    ++Q+E+   +E E +++
Sbjct: 486  EKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKK 545

Query: 1093 DSEEEEDDADSSLESPEENNPLRLSESKKS 1122
                E ++    L+   E    R+ E + S
Sbjct: 546  AILTESENKLRDLQQEAETYRTRILELESS 575



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 37/195 (18%), Positives = 91/195 (46%), Gaps = 15/195 (7%)

Query: 1    MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE 60
            M   E +  L  L +E ++E EE+ + E+E+ +++   ++  L    +  L+  E ELE 
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014

Query: 61   LRAQVLQLVAELEETRELAGQHEDDSLELQGLL----EDERLASAQQAEVFTKQIQQLQG 116
               + +    E+E   EL   H++++ +L   +    +D +  + +  E+   + +++  
Sbjct: 2015 TIKETINKAQEVE--AELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072

Query: 117  ELRSLREEISLLEHEKESELKEIE---------QELHLAQAEIQSLRQAAEDSATEHESD 167
            ++R L+ ++  L+ + + +L++ E          EL    A+  +L   ++    E    
Sbjct: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQ 2132

Query: 168  IASLQEDLCRMQNEL 182
            I +L++ L + +  +
Sbjct: 2133 IHNLEDRLKKYEKNV 2147


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  122 bits (307), Expect = 2e-27
 Identities = 218/1066 (20%), Positives = 431/1066 (40%), Gaps = 162/1066 (15%)

Query: 16   EEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELE-- 73
            E   ++   E++ +   +V        L V     LS   +E   +  + L L A+LE  
Sbjct: 1871 EMHADKSSREDIGDNVAKVNDSWKERFLDVENE--LSRIRSEKASIEHEALYLEADLEVV 1928

Query: 74   ETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKE 133
            +T +L  + ++++ +   +  +E L+      V T +  QL+GEL ++ ++ + L+   E
Sbjct: 1929 QTEKLCLEKDNENKQKVIVCLEEELS------VVTSERNQLRGELDTMSKKTTALDQLSE 1982

Query: 134  SELKEIEQELHLAQAEIQSLRQAAEDSATEH-------ESDIASLQEDLCRMQNELEDME 186
             ++KE  QEL   Q+E     Q AE    E         SD++ L +D   +Q +L+ +E
Sbjct: 1983 -KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLE 2041

Query: 187  R-------IRGDYEMEIASLRAEMEM---KSSEPSGSLGLSDY----------------- 219
            +        + + E +IA L  E E+   +S      L  SDY                 
Sbjct: 2042 KDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKG 2101

Query: 220  ------SGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQ-----RATER 268
                  S  QEE+ +LR     L     A ++    +  +L + E E           ER
Sbjct: 2102 EFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLER 2161

Query: 269  WLQ----SQTLSMTSAESQTSEMDFLEPDPE------------MQLLRQQLRDAEEQMHG 312
             LQ    +Q L +  AE+  +E++ L+   E            +  LR +  +  +Q+  
Sbjct: 2162 ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQE 2221

Query: 313  MKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLC 372
             + +  EL   L   +   +  E+ + +++ E K A  E+L+ Q    + +  E  + LC
Sbjct: 2222 KQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAV-EMLQNQ----LKELNEAVAALC 2276

Query: 373  TLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNV 432
              Q+    ++   +  ++ + QL+  + +L+           EK+ LC LQ+L     + 
Sbjct: 2277 GDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA-----DEKKQLCVLQQLKESEHHA 2331

Query: 433  TCEKEKL--LERQQQLQEELQCHEA-ELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQ 489
               K ++  LER+ ++    Q H A E ++ +  V + K   E  T++   L+      +
Sbjct: 2332 DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIR 2391

Query: 490  ASKDEL--ERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQ 547
            + K+ L  E QK      E +++    E    +      + K K +   + L ++L EL 
Sbjct: 2392 SEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2451

Query: 548  EKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHR-----LTLPLPKSGLLLK-- 600
            E+  A   +    + ++  L      ++ E+ QL + L       + L    +GL+ +  
Sbjct: 2452 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE 2511

Query: 601  --SQELLTKLEDLCELQLLYQGMQEEQKKL--IQNQDCVLKEQ----------LEIHEEL 646
               Q+L  K E++  L+   Q  ++   KL  ++ +  + KEQ          LE   ++
Sbjct: 2512 DGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQV 2571

Query: 647  RRFKESHFQEVLENPDDS--------KLAKSSKCNR-NKQSKLLMEQMQALQVMYDAGQA 697
             + K +  Q+ LE    S        +L K  K +   K +K+  ++ +  + M++  Q 
Sbjct: 2572 LQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQK 2631

Query: 698  KQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNEN 757
              EL ++  G    E+ RL  +LQL LEE++  + Q   + +      KS   M      
Sbjct: 2632 TAELQEELSG----EKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM------ 2681

Query: 758  CRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSI----- 812
                           +K     +   +  +  Y      +E   ++    +N        
Sbjct: 2682 ---------------HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQ 2726

Query: 813  TYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQA--MYQIS 870
            TY++   S     + QK  +    D   +  E++    +   ++L +L+  +   +  ++
Sbjct: 2727 TYREKLTSKEECLSSQKLEI----DLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVN 2782

Query: 871  Q--EEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTK 928
            Q  +E+ + Q +M+ L+   K L+EE +  ++E  +     EK         ++ EL T+
Sbjct: 2783 QLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTE 2842

Query: 929  LRELQLQYQAS-------MDEQGRLLVVQEQLEGQLQCCQEELRQL 967
            ++EL+   +         +D+   LL+  E+LE   +  + ++  L
Sbjct: 2843 IKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888



 Score =  115 bits (289), Expect = 2e-25
 Identities = 233/1234 (18%), Positives = 507/1234 (41%), Gaps = 194/1234 (15%)

Query: 13   LYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRG-LSLTETELEELRAQVLQLVAE 71
            L  E +   E  E +E+ ++++     V    VN   G L+  + ++E+L  ++ +  +E
Sbjct: 65   LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124

Query: 72   LEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHE 131
            LE +++ A Q  D SL                 ++FT  +   Q    S  E++    ++
Sbjct: 125  LERSQQ-AAQSADVSLN----------PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNK 173

Query: 132  KESELKEIEQELHLAQAE--IQSLRQAAED----SATEHESDIASLQEDLCRMQNELEDM 185
            +  E K +E E+   QA+   Q+L QA  +    +  +  S + S Q++  +  + L   
Sbjct: 174  EVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE--KTPSHLSSN 231

Query: 186  ER---IRGDY-------EMEIASLRAEMEMKSSEPSGSLGLSDYSG-----LQEELQELR 230
             +   IR D+       E E+   R+ +++   + + S   +  S      L+ + QELR
Sbjct: 232  SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291

Query: 231  ERYHFLNEEYRALQESNSSLTGQL---ADLESERTQRATERWLQSQTLSMTSAESQTSEM 287
             +   +NE    LQ     + GQ+    +L+ +  +   E   + + L+    E   +  
Sbjct: 292  NK---INELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTA 348

Query: 288  DFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEE-LQHHRQVSEEEQRRLQRELK 346
             + +   +   L Q+L+   E +   +   +   C LE+ ++   +  +EE  R QR  +
Sbjct: 349  QYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ 408

Query: 347  CAQNEVLRFQTS-----------HSVTQNE----------------ELKSRLCTLQKKYD 379
                E ++ +             H+V Q E                E K +LC  ++ + 
Sbjct: 409  TLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQ 468

Query: 380  TSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKEL--LCRLQKLHLQHQNVTCEKE 437
             SQ ++NEL +   +++ E        + L+++ SE++   +C L+    + +N+    +
Sbjct: 469  ASQIKENELRRSMEEMKKE--------NNLLKSHSEQKAREVCHLE---AELKNI----K 513

Query: 438  KLLERQQQLQEELQC-HEAELQHLRDTVASFKESNEKDTETHAQL--QEMKQLYQASKDE 494
            + L + Q   EE++  + ++   LRD      +     T    +L   ++++    S+D 
Sbjct: 514  QCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL 573

Query: 495  LERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLS--------RLTEL 546
            L++++H  +QL   L   + E K L ++  + + + +   +  TL S         LT++
Sbjct: 574  LKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQM 633

Query: 547  QEKYKASQKEMGQL-------QMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLL 599
            + + +  Q ++  L       Q++  E  E  R ++ ++  L  E+  L   L    + +
Sbjct: 634  ESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEV 693

Query: 600  KSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQL----------------EIH 643
            ++Q+L        ELQ   +   ++ +K I+N  C+   QL                EI 
Sbjct: 694  ETQKLA-----YMELQQKAEFSDQKHQKEIENM-CLKTSQLTGQVEDLEHKLQLLSNEIM 747

Query: 644  EELRRFKESHFQ-EVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELL 702
            ++ R +++ H + E L +   SK A       +++S L  +Q  A+   +         +
Sbjct: 748  DKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSF-------ANI 800

Query: 703  QQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTY 762
              EQG +  ER   + +     +   +LQ +  S++ SLES  +        N + +K  
Sbjct: 801  IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQ-------MNSDLQKQC 853

Query: 763  DTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTS 822
            +  V       ++    +   +SF+         S+   K    TS       ++  +  
Sbjct: 854  EELVQIKGEIEENLMKAEQMHQSFV------AETSQRISKLQEDTSAHQNVVAETLSALE 907

Query: 823  SSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQL----Q 878
            + +  +   ++   + E AE +++++   ++   L +LQ +     + ++E S +    +
Sbjct: 908  NKEK-ELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966

Query: 879  EQMEKLLAKQKDLKEELDACERE----------FKECMECLEKPMAPQNDK--------- 919
             ++E+L  +   LKE   +  +E          F   ++  EK ++  +D+         
Sbjct: 967  REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026

Query: 920  NEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQL-----REKRPSV 974
               +E      +L  +Y+A+ ++  +L  +  +     +  + EL QL     +E +  +
Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFL 1086

Query: 975  VKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLA 1034
             K A  +  N+N+      V+    ++   + + S  E     + ++  K  Q K+    
Sbjct: 1087 TKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKM---- 1142

Query: 1035 KEEEKKEEMEEEKKQVK-EEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEED 1093
             ++E  + ++E ++ +K  + K +C      +  + E  +++  + E+E ++   + + D
Sbjct: 1143 -QKEVNDLLQENEQLMKVMKTKHEC------QNLESEPIRNSVKERESERNQCNFKPQMD 1195

Query: 1094 SEEEEDDADS------SLESPEENNPLRLSESKK 1121
             E +E   DS       LE+   N  L+L ES+K
Sbjct: 1196 LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEK 1229



 Score =  109 bits (272), Expect = 2e-23
 Identities = 209/1044 (20%), Positives = 427/1044 (40%), Gaps = 123/1044 (11%)

Query: 134  SELKEIEQELHLAQAEIQSLRQAA---EDSATEHESDIASLQEDL----CRMQNELEDME 186
            +E+KE++ +LHL + ++ +  +A    E    E + + + L E L    C  Q  L+ +E
Sbjct: 1802 NEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE 1861

Query: 187  RIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQES 246
               G        L +++EM + + S    + D   + +     +ER+  +  E   ++  
Sbjct: 1862 TSEG--------LNSDLEMHADKSSRE-DIGD--NVAKVNDSWKERFLDVENELSRIRSE 1910

Query: 247  NSSLTGQL----ADLESERTQR-ATERWLQSQTLSMTSAESQ----TSEMDFLEPDPEMQ 297
             +S+  +     ADLE  +T++   E+  +++   +   E +    TSE + L    E+ 
Sbjct: 1911 KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLR--GELD 1968

Query: 298  LLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQT 357
             + ++    ++    MK K QEL     E  H  QV+E E +     L+   ++V     
Sbjct: 1969 TMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDV----- 2023

Query: 358  SHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKE 417
                    EL      LQ+K  + + +   L   + +L+ ++ QL   K  LV  +  + 
Sbjct: 2024 -------SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLV--KESES 2074

Query: 418  LLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTET 477
            L  RL +   +  NV+   E  L  + +    L   + E+  LR  +   +   E D + 
Sbjct: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK 2134

Query: 478  HAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCD 537
               + E  +  +   D L   K   + LE++L + + E +EL     +  D      + +
Sbjct: 2135 QLHIAEKLKERERENDSL---KDKVENLERELQMSE-ENQEL-----VILDAENSKAEVE 2185

Query: 538  TLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGL 597
            TL +++ E+    K  + ++  L+ E+  L    +++QE+QGQL  EL +L L   KS L
Sbjct: 2186 TLKTQIEEMARSLKVFELDLVTLRSEKENL---TKQIQEKQGQL-SELDKL-LSSFKSLL 2240

Query: 598  LLKSQ-ELLTKLEDLCELQLLYQGMQE--------------------------EQKKLIQ 630
              K Q E+  K E    +++L   ++E                          E++  ++
Sbjct: 2241 EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLR 2300

Query: 631  NQDCVLKEQLEIHEE-----LRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLME-- 683
            N    L+ +LE  E+     L++ KES     L       L +  +  R  Q    +E  
Sbjct: 2301 NSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAE 2360

Query: 684  ----QMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKM 739
                +++ L+   +        L+ +   +  E++ L  +LQ   E +  L++ + S + 
Sbjct: 2361 NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFEN 2420

Query: 740  SLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEA 799
             L+   +    M   +    +   T + +      +  + Q + K+  ++  S     E 
Sbjct: 2421 ILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLEL 2480

Query: 800  YGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMV---VKV 856
                     + +   K +Y    SS       V     +   + E++ R +  +    ++
Sbjct: 2481 EKAQLLQGLDEA---KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQL 2537

Query: 857  LIKLQAVQAMYQISQEEH-------SQLQEQMEKLLAKQKDLKEELDACEREFKECMECL 909
            + KL  V+  +Q+ +E++        +L+++++ L +K   L++ L+  +  +K     L
Sbjct: 2538 VSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597

Query: 910  EKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQG-RLLVVQEQLEGQLQCCQEELRQLR 968
            E     + DK    E   K+   + + Q  M E   +   +QE+L G+      EL+ L 
Sbjct: 2598 E---LTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLL 2654

Query: 969  EKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSL-EVVLYYKASQ 1027
            E+  S       K+  K +    + +K K +     D  E + + R+ + E  L    ++
Sbjct: 2655 EEIKS------SKDQLKELTLENSELK-KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAE 2707

Query: 1028 RKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEE 1087
            +K   L  +  K+ E+E +  + K  +KE+C   L ++  + +  KS++++  N      
Sbjct: 2708 KKHQALLLDTNKQYEVEIQTYREKLTSKEEC---LSSQKLEIDLLKSSKEELNNSLKATT 2764

Query: 1088 EEKEEDSEEEEDDADSSLESPEEN 1111
            +  EE  + + D+     +  +EN
Sbjct: 2765 QILEELKKTKMDNLKYVNQLKKEN 2788



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 229/1096 (20%), Positives = 439/1096 (40%), Gaps = 198/1096 (18%)

Query: 16   EEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEET 75
            E+     E  E   E +Q  K  ++    V+        E  LE  +     L  + EE 
Sbjct: 803  EQGSMPSERSECRLEADQSPKNSAILQNRVDS------LEFSLESQKQMNSDLQKQCEEL 856

Query: 76   RELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS----LREEISLLEHE 131
             ++ G+ E++      L++ E++  +  AE  +++I +LQ +  +    + E +S LE+ 
Sbjct: 857  VQIKGEIEEN------LMKAEQMHQSFVAET-SQRISKLQEDTSAHQNVVAETLSALEN- 908

Query: 132  KESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGD 191
            KE EL+ +  ++   QAEIQ L+++                       + LED  +    
Sbjct: 909  KEKELQLLNDKVETEQAEIQELKKS----------------------NHLLEDSLK---- 942

Query: 192  YEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLT 251
             E+++ S    +E K      SL   +   L +E   L+E    LN+E   L + + S  
Sbjct: 943  -ELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001

Query: 252  GQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQ-- 309
              + + E   ++  ++++ Q + + +   E         E     + L Q+ + A+E+  
Sbjct: 1002 NYIDEREKSISE-LSDQYKQEKLILLQRCE---------ETGNAYEDLSQKYKAAQEKNS 1051

Query: 310  -MHGMKNKCQELC----CELEELQH-----HRQV------SEEEQRRLQRELKCAQNEVL 353
             +  + N+C  LC     ELE+L+      H++       +EE  + L  EL+  Q  + 
Sbjct: 1052 KLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR 1111

Query: 354  RFQTSHSVTQNEE---LKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLV 410
               T +      E   LK  + TL+++ +  Q E N+LL+   QL      +KVMK+   
Sbjct: 1112 SEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL------MKVMKTKHE 1165

Query: 411  ENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKES 470
                E E +    K     +N    K ++    +++   L  + A+L  L    A  +  
Sbjct: 1166 CQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEIS--LDSYNAQLVQLE---AMLRNK 1220

Query: 471  NEKDTETHAQLQEMKQLYQASKDELERQ--KHMYDQLEQDLLLCQLELKELKASHP---- 524
              K  E+  + + ++   Q  + +LE    + M  Q    L  C+++ +E   S P    
Sbjct: 1221 ELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS 1280

Query: 525  -IPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQME----QCELLEDQRRMQEEQG 579
                D         T +++L EL++  +  Q E  +L  E    + E +   R+M EE G
Sbjct: 1281 TSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVG 1340

Query: 580  QLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQ 639
            +L  E+  L      SGLL    EL+   ED+   +   Q  ++    L    +    E 
Sbjct: 1341 KLLNEVKILN---DDSGLL--HGELV---EDIPGGEFGEQPNEQHPVSLAPLDESNSYEH 1392

Query: 640  LEIHEELRRFKESHFQE-VLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAK 698
            L + ++  +   +  QE  L    + K+     C        +  +M  LQ   D+ +A+
Sbjct: 1393 LTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQ-------MSSKMSELQTYVDSLKAE 1445

Query: 699  QELLQQE----QGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPS 754
              +L       QG L++E       +QL LEE          +  SL S      S VP 
Sbjct: 1446 NLVLSTNLRNFQGDLVKE-------MQLGLEE---------GLVPSLSS------SCVPD 1483

Query: 755  NENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE-AYGKSYCTTSNSSIT 813
            + +     D+      S+Y++    QT   S L + + + SA++ +  + +C++      
Sbjct: 1484 SSSLSSLGDS------SFYRALLE-QTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENL 1536

Query: 814  YKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEE 873
             +K                     E P+ P           K + +L+++  +Y+ S E+
Sbjct: 1537 TRK---------------------ETPSAP----------AKGVEELESLCEVYRQSLEK 1565

Query: 874  HSQLQEQMEKL-LAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLREL 932
               L+E+ME   + K K+++E       E +E ++CL K    +N+     + Q KL  +
Sbjct: 1566 ---LEEKMESQGIMKNKEIQELEQLLSSERQE-LDCLRKQYLSENE-----QWQQKLTSV 1616

Query: 933  QLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVV-----KEARGKNANKNM 987
             L+ ++ +  + +     EQL  +L+  + +L+ L     S++        +G+N + ++
Sbjct: 1617 TLEMESKLAAEKK---QTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDI 1673

Query: 988  NKNANGVKMKKVTK-PCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEE 1046
            +K       ++  K       + D +   +L++    +    K  G    E+  +   E 
Sbjct: 1674 SKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEP 1733

Query: 1047 KKQVKEEAKEQCGDEL 1062
              + K +   +C  EL
Sbjct: 1734 PGEDKTQGSSECISEL 1749



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 206/1084 (19%), Positives = 415/1084 (38%), Gaps = 166/1084 (15%)

Query: 52   SLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQI 111
            +LT  E     A+ ++ +  L E    + +  ++ +E QG++++             K+I
Sbjct: 1535 NLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKN-------------KEI 1581

Query: 112  QQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASL 171
            Q+L+  L S R+E+  L  +  SE ++ +Q+L     E++S + AAE   TE      SL
Sbjct: 1582 QELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMES-KLAAEKKQTEQ----LSL 1636

Query: 172  QEDLCRMQNE---LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQE 228
            + ++ R+Q +   L     +  D E  I       ++     S +   +    + +    
Sbjct: 1637 ELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD- 1695

Query: 229  LRERYHFLNEEYRALQESNS-SLTGQLADLESERTQRATERWLQSQTLSMTSAESQTS-- 285
             ++    LN +   + E+ +   TG+ +  +S  T        ++Q  S   +E   S  
Sbjct: 1696 -KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGP 1754

Query: 286  ----EMDFL--------------EPDPEMQLLRQQLRDAEEQMHGMKNKCQEL------- 320
                 MDFL              E   E   L   + D + ++  + N+ +EL       
Sbjct: 1755 NALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQ 1814

Query: 321  ----------CCELEELQHHRQVSEEEQRRLQRELKCAQNEVL-RFQTSHSVTQNEELKS 369
                      C ELE++    +    +         C   E+L R +TS  +  + E+ +
Sbjct: 1815 EVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA 1874

Query: 370  RLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQH 429
               + +   D      +   +  L ++ EL +++  K+++     E E L     L    
Sbjct: 1875 DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASI-----EHEALY----LEADL 1925

Query: 430  QNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQ 489
            + V  EK  L +  +  Q+ + C E EL  +        E N+   E     ++   L Q
Sbjct: 1926 EVVQTEKLCLEKDNENKQKVIVCLEEELSVVTS------ERNQLRGELDTMSKKTTALDQ 1979

Query: 490  ASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEK 549
             S+   E+ + +     + L   Q+   E+K    + +     ++    LL   T LQEK
Sbjct: 1980 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQT---LSSDVSELLKDKTHLQEK 2036

Query: 550  YKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGL--LLKSQELLTK 607
             ++ +K+   L + +CEL     ++ +E+  L +E   L   L +S    L  S+ L   
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2096

Query: 608  LEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLA 667
            L +  E  L     QEE  +L +       E+L +  E    K+ H  E L+        
Sbjct: 2097 LVEKGEFALRLSSTQEEVHQLRRGI-----EKLRVRIEADEKKQLHIAEKLKE------- 2144

Query: 668  KSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEM 727
                  R +++  L ++++ L+      +  QEL+                D +    E+
Sbjct: 2145 ------RERENDSLKDKVENLERELQMSEENQELVI--------------LDAENSKAEV 2184

Query: 728  QLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFL 787
            + L+ Q   +  SL+ +     ++    EN  K     + + +          +S KS L
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQ----IQEKQGQLSELDKLLSSFKSLL 2240

Query: 788  KSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEP-EDM 846
            +  + +    E   K    T+   +  +    + + +  C    +   T++    P E+ 
Sbjct: 2241 EEKEQA----EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEE 2296

Query: 847  ERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECM 906
             +    + K+  +L+A +       ++  + +   + L  + ++L+ EL+      +   
Sbjct: 2297 HQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAA 2356

Query: 907  ECLEKPMAPQNDKNEIKELQTK-------LRELQL--------------QYQASMDEQGR 945
                  +  +N K E++ L+ K       LR L+L              + Q   +    
Sbjct: 2357 ------LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISE 2410

Query: 946  LLVVQEQLEGQLQCCQEELRQLREKRPSVV-------KEARGKNANKNMNKNANGVKMKK 998
            L ++    E  LQ  ++E  Q++EK  + +       KE   + A  + ++ A   K + 
Sbjct: 2411 LEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN 2470

Query: 999  VTKP--CSDTSESDL----ETRKSLEVVLYYKAS---QRKLDGLAKEEEKKEEMEEEKKQ 1049
            ++    C +  ++ L    +  K+  +VL    +   Q   DG  K E+K EE+   K Q
Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2530

Query: 1050 VKEE 1053
            ++++
Sbjct: 2531 IQDQ 2534



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 229/1184 (19%), Positives = 457/1184 (38%), Gaps = 159/1184 (13%)

Query: 53   LTETELEELRAQVLQLVAEL--EETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQ 110
            LT+    E R Q L L  E   +  R     ++++S    G L+ E +   ++     K+
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKE 1145

Query: 111  IQQLQGELRSL------REEISLLEHEK-ESELKEIEQELHLAQAEIQSLRQAAEDSATE 163
            +  L  E   L      + E   LE E   + +KE E E +    + Q   +  E S   
Sbjct: 1146 VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1205

Query: 164  HESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEME------MKSSEPSG----- 212
            + + +  L+  L   + +L++ E+ +   + E+ ++R ++E      M+S E SG     
Sbjct: 1206 YNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCE 1265

Query: 213  --------------SLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLE 258
                          S   +D + LQ  LQ    + + L +    LQ     L  +L D  
Sbjct: 1266 IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR 1325

Query: 259  SERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMK---- 314
            SE    AT +  +     +   +    +   L  +    +   +  +   + H +     
Sbjct: 1326 SECIT-ATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL 1384

Query: 315  ---NKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQN--EELKS 369
               N  + L    +E+Q H    +E+   LQ E K   ++  +  +  S  Q   + LK+
Sbjct: 1385 DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKA 1444

Query: 370  RLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELL-----CRLQK 424
                L       ++ Q +L+K ++QL  E   +  + S+ V + S    L      R   
Sbjct: 1445 ENLVLSTNL---RNFQGDLVK-EMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALL 1500

Query: 425  LHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEM 484
                  ++    E  +   Q   +E+ C   + ++L     + KE+     +   +L+ +
Sbjct: 1501 EQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENL-----TRKETPSAPAKGVEELESL 1555

Query: 485  KQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLT 544
             ++Y+ S ++LE      +++E   ++   E++EL+        +  C  K    LS   
Sbjct: 1556 CEVYRQSLEKLE------EKMESQGIMKNKEIQELEQLLSSERQELDCLRK--QYLSENE 1607

Query: 545  ELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLP----LPKSGLLLK 600
            + Q+K  +   EM      + +L  +++  Q EQ  L+ E+ RL L       +S L + 
Sbjct: 1608 QWQQKLTSVTLEM------ESKLAAEKK--QTEQLSLELEVARLQLQGLDLSSRSLLGID 1659

Query: 601  SQELLTKLEDLCELQLLYQGMQEEQK-KLIQNQDCVLKEQLEIHEELRRFKESHFQEVL- 658
            +++ +    + C++   +     E+  K   +Q C    Q +++ ++ +  E+   +   
Sbjct: 1660 TEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTG 1719

Query: 659  ------------ENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAG--------QAK 698
                        E P + K   SS+C     S+L      AL  M   G        Q +
Sbjct: 1720 ECSGEQSPDTNYEPPGEDKTQGSSECI----SELSFSGPNALVPMDFLGNQEDIHNLQLR 1775

Query: 699  QELLQQEQGRLL---EERKRL---------QADLQLCLEEMQLLQVQSPSIKMSLESYGK 746
             +    E  RLL   E+R R          + D +L L+E+QL+      I++      K
Sbjct: 1776 VKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELE-----K 1830

Query: 747  SYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSST---------SAS 797
              G +   N +  +  +    D++   +   +++  +       D S+           +
Sbjct: 1831 IVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVN 1890

Query: 798  EAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVL 857
            +++ + +    N     +    S        ++ +     E+    +D E  ++++V + 
Sbjct: 1891 DSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLE 1950

Query: 858  IKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQN 917
             +L  V +     + E   + ++   L    + +KE+    E    EC+ C++   A   
Sbjct: 1951 EELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVK 2010

Query: 918  DKNEIKE-LQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQC-CQEELRQLREKRPSVV 975
            +K E+ + L + + EL L+ +  + E+ + L    Q     +C  + ++ QL +++  +V
Sbjct: 2011 EKTELLQTLSSDVSEL-LKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLV 2069

Query: 976  KEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAK 1035
            KE+    A                    S++    L   K+LE  L  K          +
Sbjct: 2070 KESESLQAR------------------LSESDYEKLNVSKALEAALVEKGEFALRLSSTQ 2111

Query: 1036 EEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPE-EAKSTEDQEENEEDKEEEEKEEDS 1094
            EE  +     EK +V+ EA E+    +  +  + E E  S +D+ EN E +E +  EE+ 
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE-RELQMSEENQ 2170

Query: 1095 EEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGL 1138
            E    DA++S ++  E    ++ E  +S       +F L LV L
Sbjct: 2171 ELVILDAENS-KAEVETLKTQIEEMARSL-----KVFELDLVTL 2208



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 148/730 (20%), Positives = 279/730 (38%), Gaps = 87/730 (11%)

Query: 422  LQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTV-------ASFKESNEKD 474
            LQK+    Q +  + +KL + +QQ Q +L   EA LQ  +  V        + K  N++ 
Sbjct: 17   LQKI----QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL 72

Query: 475  TETHAQLQEMKQ-----------LYQASKDELERQKHMYDQLEQDLLLCQLELKELKASH 523
             E    L++ KQ                + +L   K   ++LEQ+L  C+    EL+ S 
Sbjct: 73   MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK---SELERSQ 129

Query: 524  PIPEDKGKCANKCDT---LLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQ 580
               +      N C+T   + +      + Y  S+ E   L+ +  + +E+++R++ E   
Sbjct: 130  QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYE--DLKEKYNKEVEERKRLEAEVKA 187

Query: 581  LQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQL 640
            LQ +    TLP           +      D+   Q        +Q+K   +    L    
Sbjct: 188  LQAKKASQTLP-----------QATMNHRDIARHQASSSVFSWQQEKTPSH----LSSNS 232

Query: 641  EIHEELRRFKESHF---QEVLENPDDSKLAK---SSKCNRNKQSKLLMEQMQALQVMYDA 694
            +     R F  S+F   QEV  +    ++ K   +S    N  S  L++Q++A       
Sbjct: 233  QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRN 292

Query: 695  GQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSI--------KMSLESYGK 746
               + EL  Q   + ++ +     +LQL LE+ ++  ++   +          +   Y +
Sbjct: 293  KINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQ 352

Query: 747  SYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCT 806
            +        +  +K  +      ++   +  S +   K   K +    S  +   +S+ T
Sbjct: 353  ASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ---RSFQT 409

Query: 807  TSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDME-RFEEMVVKVLIKLQAVQA 865
                 I  K              + + +  D+  +  + +E   EE   K+    QA QA
Sbjct: 410  LDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQA 469

Query: 866  MYQISQEEHSQLQEQMEK---LLAKQKDLK-EELDACEREFKECMECLEKPMAPQNDKNE 921
              QI + E  +  E+M+K   LL    + K  E+   E E K   +CL +    QN   E
Sbjct: 470  S-QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQ---SQNFAEE 525

Query: 922  IKELQTKLRELQLQYQASMDEQGRLLVVQE------QLEGQLQCCQEELR-------QLR 968
            +K   T    +    Q  +++Q   L +++       LE Q  C Q+ L+       QL 
Sbjct: 526  MKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLN 585

Query: 969  EKRPSVVKEARG-KNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQ 1027
            +K     KE++   +A +   K    +K +K    C  +    L T+   E     ++  
Sbjct: 586  DKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKE-NLQSKI 644

Query: 1028 RKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEE 1087
              L+   K ++ K     E+ +  E  +E    E +    +  ++KS E + +     E 
Sbjct: 645  NHLETCLKTQQIKSHEYNERVRTLEMDRENLSVE-IRNLHNVLDSKSVEVETQKLAYMEL 703

Query: 1088 EEKEEDSEEE 1097
            ++K E S+++
Sbjct: 704  QQKAEFSDQK 713


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  122 bits (307), Expect = 2e-27
 Identities = 224/1077 (20%), Positives = 456/1077 (42%), Gaps = 160/1077 (14%)

Query: 2    QAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEEL 61
            Q ++ ++ L A  +E  E  EEEEE+  E            L+  K +     E E  EL
Sbjct: 910  QLIKNKIQLEAKIKEVTERAEEEEEINAE------------LTAKKRK----LEDECSEL 953

Query: 62   RAQV--LQLVAELEETRELAGQHEDDSL--ELQGLLEDERLAS-AQQAEVFTKQIQQLQG 116
            +  +  L+L     E  + A +++  +L  E+ GL  DE +A  +++ +   +  QQ   
Sbjct: 954  KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL--DETIAKLSKEKKALQETHQQTLD 1011

Query: 117  ELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLC 176
            +L++  +++++L   K ++L++   +L  +  + + LR   E +  + E D+   QE   
Sbjct: 1012 DLQAEEDKVNILTKAK-TKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070

Query: 177  RMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFL 236
             M+N+ + ++      E EI++L +++E + +             LQ++++EL+ R   L
Sbjct: 1071 DMENDKQQLDEKLEKKEFEISNLISKIEDEQAVE---------IQLQKKIKELQARIEEL 1121

Query: 237  NEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEM 296
             EE  A + S +    Q +DL S   +  +ER    +    TSA+ + ++    + + E 
Sbjct: 1122 GEEIEAERASRAKAEKQRSDL-SRELEEISER--LEEAGGATSAQVELNK----KREAEF 1174

Query: 297  QLLRQQLRDAEEQMHGM--------KNKCQELCCELEELQHHRQVSEEEQRRLQRELKCA 348
            Q LR+ L +A  Q   M         +   EL  +++ LQ  +Q  E+E+  L+ E    
Sbjct: 1175 QKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDL 1234

Query: 349  QNEV----------------LRFQTSHSVTQNEE----------LKSRLCTLQKKYDTSQ 382
             +                  L  Q S   T+ EE           ++RL T   +Y    
Sbjct: 1235 SSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQL 1294

Query: 383  DEQNELL-KMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCE--KEKL 439
            DE++ L+ ++    Q   +Q++ +K  L E    K  L       LQ     C+  +E+ 
Sbjct: 1295 DEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHA----LQSSRHDCDLLREQY 1350

Query: 440  LERQQ---QLQEELQCHEAELQHLR-----DTVASFKESNEKDTETHAQLQEMKQLYQAS 491
             E Q+   +LQ  L    +E+   R     D +   +E  E   +   +LQE ++  +A 
Sbjct: 1351 EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAV 1410

Query: 492  KDE---LERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLS----RLT 544
              +   LE+ K       +DL+L      +++ S+       K     D +LS    +  
Sbjct: 1411 NAKCASLEKTKQRLQNEVEDLML------DVERSNAACAALDKKQRNFDKVLSEWKQKYE 1464

Query: 545  ELQEKYKASQKEMGQLQMEQC-------ELLEDQRRMQEEQGQLQEELHRLTLPLPKSGL 597
            E Q + +ASQKE   L  E         E L+    ++ E   LQ+E+  LT  + + G 
Sbjct: 1465 ETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGK 1524

Query: 598  LLKSQELLTKL--EDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIH------------ 643
             +   E + K   ++ CE+Q     ++E +  L   +  +L+ QLE++            
Sbjct: 1525 QIHELEKIKKQVEQEKCEIQ---AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1581

Query: 644  --EELRRFKESHFQ--EVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQ 699
              EE+ + K +H +  E +++  D+++   +   R K+          +Q+ +    A +
Sbjct: 1582 KDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAE 1641

Query: 700  EL--LQQEQGRL------LEERKRLQADL--QLCLEEMQ--LLQVQSPSIKMSLESYGKS 747
             L   +  QG L      L++  R Q DL  QL + E +  LLQ +   +  +LE   +S
Sbjct: 1642 SLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERS 1701

Query: 748  ----YGSMVPSNENCR--KTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYG 801
                   ++ ++E  +   T +T++ + +   ++  S   S     +    S +A E   
Sbjct: 1702 RKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVE--EVIQESRNAEEKAK 1759

Query: 802  KSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTD----EEPAEPEDMERFEEMVVKVL 857
            K+    +  +   KK   +++  +  +K+   +  D     + AE   ++  ++ + K+ 
Sbjct: 1760 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1819

Query: 858  IKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQN 917
             +++ ++   +  Q+ +++  + + K   + K+L  + +   +      + ++K  A   
Sbjct: 1820 ARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQA--- 1876

Query: 918  DKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSV 974
               ++K  + +  E + Q  A++ +  +L    E+ E +    + ++ +LR K   V
Sbjct: 1877 ---KVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1930



 Score =  106 bits (264), Expect = 1e-22
 Identities = 223/1150 (19%), Positives = 448/1150 (38%), Gaps = 161/1150 (14%)

Query: 15   EEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHR-GLSLTETELEELRAQVLQLVAELE 73
            +E  + E + +E+EE+   + K  +   L V      L+  E   E+L    +QL A+++
Sbjct: 864  DELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIK 923

Query: 74   ETRELAGQHEDDSLELQGL---LEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEH 130
            E  E A + E+ + EL      LEDE     +  +     + +++ E  +   ++  L  
Sbjct: 924  EVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 983

Query: 131  EKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRG 190
            E    L E   +L   +  +Q   Q   D     E  +  L +   +++ +++D+E   G
Sbjct: 984  EMAG-LDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLE---G 1039

Query: 191  DYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSL 250
              E E   LR ++E    +  G L L+     QE   ++      L+E+    +   S+L
Sbjct: 1040 SLEQE-KKLRMDLERAKRKLEGDLKLA-----QESTMDMENDKQQLDEKLEKKEFEISNL 1093

Query: 251  TGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQM 310
              ++ D      ++A E  LQ +   + +   +  E        E++  R     AE+Q 
Sbjct: 1094 ISKIED------EQAVEIQLQKKIKELQARIEELGE--------EIEAERASRAKAEKQR 1139

Query: 311  HGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSR 370
              +  + +E+   LEE         E  ++ + E      + LR     +  Q+E +   
Sbjct: 1140 SDLSRELEEISERLEEAGGATSAQVELNKKREAEF-----QKLRRDLEEATLQHEAM--- 1191

Query: 371  LCTLQKKYDTSQDEQNE----LLKMQLQLQTELRQLKVMKSTLVEN-QSEKELLCRLQKL 425
            +  L+KK+  S  E  E    L +++ +L+ E  +LK+    L  N ++  +    L+K+
Sbjct: 1192 VAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKM 1251

Query: 426  HLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMK 485
                ++   E +   E QQ+L  +L    A LQ   +     ++ +EKD    A + ++ 
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQ--TEAGEYSRQLDEKD----ALVSQLS 1305

Query: 486  QLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTE 545
            +  QAS  ++E  KH   QLE+          E KA + +        + CD L  +  E
Sbjct: 1306 RSKQASTQQIEELKH---QLEE----------ETKAKNALAHALQSSRHDCDLLREQYEE 1352

Query: 546  LQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELL 605
             QE     Q+ + +   E  +    + + + +  Q  EEL      L +   L +++E +
Sbjct: 1353 EQEGKAELQRALSKANSEVAQW---RTKYETDAIQRTEELEEAKKKLAQR--LQEAEEHV 1407

Query: 606  TKLEDLC-ELQLLYQGMQEEQKKLI-----QNQDCVL--KEQLEIHEELRRFKESHFQEV 657
              +   C  L+   Q +Q E + L+      N  C    K+Q    + L  +K+ + +  
Sbjct: 1408 EAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQ 1467

Query: 658  LENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQ------EQGRLLE 711
             E     K ++S      K   +  E +  L+ +    +  Q+ +        E G+ + 
Sbjct: 1468 AELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIH 1527

Query: 712  ERKRLQADLQLCLEEMQLLQVQSPSIKMSLE-SYGKSYGSMVPSNENCRKTYDTTVDDNE 770
            E ++++  ++   +E   +Q      + SLE   GK     +  N+  +   D  + + +
Sbjct: 1528 ELEKIKKQVE---QEKCEIQAALEEAEASLEHEEGKILRIQLELNQ-VKSEVDRKIAEKD 1583

Query: 771  SYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKS 830
                      T      +  ++  S  +A  +S     N ++  KK      +    Q +
Sbjct: 1584 EEIDQLKRNHT------RVVETMQSTLDAEIRS----RNDALRVKKKMEGDLNEMEIQLN 1633

Query: 831  FVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKD 890
              +    E                            Y+ +Q    + Q  ++  L  Q+D
Sbjct: 1634 HANRLAAESLRN------------------------YRNTQGILKETQLHLDDALRGQED 1669

Query: 891  LKEELDACER-------EFKECMECLEKPMAPQN-DKNEIKELQTKLRELQLQYQASMDE 942
            LKE+L   ER       E +E    LE+    +   + E+ +   +++ L  Q  + ++ 
Sbjct: 1670 LKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1729

Query: 943  QGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEAR--GKNANKNMNKNANGVKMKKVT 1000
            + +L     QL+ +++   +E R   EK    + +A    +   K  + +A+  +MKK  
Sbjct: 1730 KKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1789

Query: 1001 KPCSDTSESDLETRKSLEV------VLYYKASQRKLDGLAKEEEKKE------------- 1041
            +      +  L+  + L +      +   +A  R+L+G  + E+K+              
Sbjct: 1790 EQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERR 1849

Query: 1042 ------EMEEEKKQV--------KEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEE 1087
                  + EE++K V        K +AK +       E  +   A  ++ ++   E +E 
Sbjct: 1850 VKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEA 1909

Query: 1088 EEKEEDSEEE 1097
            EE+ + +E +
Sbjct: 1910 EERADIAESQ 1919



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 224/1144 (19%), Positives = 450/1144 (39%), Gaps = 154/1144 (13%)

Query: 44   SVNKHRGLSLTETELEELRAQVLQLVAELEETRE--LAGQHEDDSLELQGLLEDERLASA 101
            S    + ++  + E ++ + ++ +  A+ +E  E  +    E + L+LQ   E + LA A
Sbjct: 845  SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904

Query: 102  QQ-AEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDS 160
            ++  E   K   QL+ +++ + E       E+E E+           AE+ + ++  ED 
Sbjct: 905  EERCEQLIKNKIQLEAKIKEVTERA-----EEEEEIN----------AELTAKKRKLEDE 949

Query: 161  ATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYS 220
             +E + DI  L+  L +++ E    E    +   E+A L   +   S E         + 
Sbjct: 950  CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKAL--QETHQ 1007

Query: 221  GLQEELQELRERYHFLNEEYRALQESNSSLTGQLAD-----LESERTQRATE---RWLQS 272
               ++LQ   ++ + L +    L++    L G L       ++ ER +R  E   +  Q 
Sbjct: 1008 QTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1067

Query: 273  QTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEEL----- 327
             T+ M + + Q  E    + + E+  L  ++ D +     ++ K +EL   +EEL     
Sbjct: 1068 STMDMENDKQQLDE-KLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIE 1126

Query: 328  --QHHRQVSEEEQRRLQREL-----------------------KCAQNEVLRFQTSHSVT 362
              +  R  +E+++  L REL                       + A+ + LR     +  
Sbjct: 1127 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATL 1186

Query: 363  QNEELKSRLCTLQKKYDTSQDEQNE----LLKMQLQLQTELRQLKVMKSTLVEN-QSEKE 417
            Q+E +   +  L+KK+  S  E  E    L +++ +L+ E  +LK+    L  N ++  +
Sbjct: 1187 QHEAM---VAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK 1243

Query: 418  LLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTET 477
                L+K+    ++   E +   E QQ+L  +L    A LQ   +     ++ +EKD   
Sbjct: 1244 AKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQ--TEAGEYSRQLDEKD--- 1298

Query: 478  HAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCD 537
             A + ++ +  QAS  ++E  KH   QLE+          E KA + +        + CD
Sbjct: 1299 -ALVSQLSRSKQASTQQIEELKH---QLEE----------ETKAKNALAHALQSSRHDCD 1344

Query: 538  TLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGL 597
             L  +  E QE     Q+    L     E+ + + + + +  Q  EEL      L +   
Sbjct: 1345 LLREQYEEEQEGKAELQR---ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR-- 1399

Query: 598  LLKSQELLTKLEDLC-ELQLLYQGMQEEQKKLI-----QNQDCVL--KEQLEIHEELRRF 649
            L +++E +  +   C  L+   Q +Q E + L+      N  C    K+Q    + L  +
Sbjct: 1400 LQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEW 1459

Query: 650  KESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQ----- 704
            K+ + +   E     K ++S      K   +  E +  L+ +    +  Q+ +       
Sbjct: 1460 KQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQI 1519

Query: 705  -EQGRLLEERKRL-------QADLQLCLEEMQ--LLQVQSPSIKMSLE------SYGKSY 748
             E G+ + E +++       + ++Q  LEE +  L   +   +++ LE         +  
Sbjct: 1520 AEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1579

Query: 749  GSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE-AYGKSYCTT 807
                   +  ++ +   V+  +S   +   ++  +    K  +   +  E     +    
Sbjct: 1580 AEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLA 1639

Query: 808  SNSSITYKKSYGSTSSSDTCQKSFVSSCTD--EEPAEPEDMERFEEMVVKVL-IKLQAVQ 864
            + S   Y+ + G    +       +    D  E+ A  E      +  ++ L   L+  +
Sbjct: 1640 AESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTE 1699

Query: 865  AMYQISQEEHSQLQEQME-------KLLAKQKDLKEELDACEREFKECMECLEKPMAPQN 917
               +I+++E     E+++        L+  +K L+ ++   + E +E ++  E   A + 
Sbjct: 1700 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQ--ESRNAEEK 1757

Query: 918  DKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLR--------E 969
             K  I +      EL+ +   S   + R+    EQ    LQ   +E  QL         +
Sbjct: 1758 AKKAITDAAMMAEELKKEQDTSAHLE-RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ 1816

Query: 970  KRPSVVKEARGKNANKNMNKNANGVK-MKKVTKPCSDTSESDLETRKSLEVVLYYKASQR 1028
            K  + V+E  G+  N+   +NA  VK ++K  +   + +    E RK+   VL  +    
Sbjct: 1817 KLEARVRELEGEVENE-QKRNAEAVKGLRKHERRVKELTYQTEEDRKN---VLRLQDLVD 1872

Query: 1029 KLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEE 1088
            KL    K  +++ E  EE+         +   EL       EEA+   D  E++ +K   
Sbjct: 1873 KLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHEL-------EEAEERADIAESQVNKLRV 1925

Query: 1089 EKEE 1092
            +  E
Sbjct: 1926 KSRE 1929



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 147/748 (19%), Positives = 300/748 (40%), Gaps = 88/748 (11%)

Query: 436  KEKLLERQQQLQEELQCHEAELQHLRDTVASF----KESNEKDTETHAQLQEMKQLYQAS 491
            K K L +  + ++E+   + E Q  +D +A      KE  EK      +  +++   Q+ 
Sbjct: 838  KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSE 897

Query: 492  KDELERQKHMYDQLEQDLLLCQLELKEL--------KASHPIPEDKGKCANKC------- 536
             D L   +   +QL ++ +  + ++KE+        + +  +   K K  ++C       
Sbjct: 898  ADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDI 957

Query: 537  DTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSG 596
            D L   L +++++  A++ ++  L  E   L E   ++ +E+  LQ E H+ TL      
Sbjct: 958  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQ-ETHQQTLD----- 1011

Query: 597  LLLKSQE----LLTKLEDLCELQL-LYQGMQEEQKKL---IQNQDCVLKEQLEIHEELRR 648
              L+++E    +LTK +   E Q+   +G  E++KKL   ++     L+  L++ +E   
Sbjct: 1012 -DLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070

Query: 649  FKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYD--------------- 693
              E+  Q++     D KL K      N  SK+  EQ   +Q+                  
Sbjct: 1071 DMENDKQQL-----DEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEI 1125

Query: 694  ----AGQAKQELLQQEQGRLLEE-RKRLQADLQLCLEEMQL---LQVQSPSIKMSLESYG 745
                A +AK E  + +  R LEE  +RL+        +++L    + +   ++  LE   
Sbjct: 1126 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEAT 1185

Query: 746  KSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLK-SYDSSTSASEAYGKSY 804
              + +MV +           + +     +         KS LK   D  +S +EA  K+ 
Sbjct: 1186 LQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAK 1245

Query: 805  CTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQ 864
                    + +       + +  Q+  ++  T +      +   +   + +    +  + 
Sbjct: 1246 GNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLS 1305

Query: 865  AMYQISQEEHSQLQEQMEK-------LLAKQKDLKEELDACEREFKECME-CLEKPMAPQ 916
               Q S ++  +L+ Q+E+       L    +  + + D    +++E  E   E   A  
Sbjct: 1306 RSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1365

Query: 917  NDKNEIKELQTKLRELQLQYQASMDE-----QGRLLVVQEQLEGQLQCCQEELRQLREKR 971
               +E+ + +TK     +Q    ++E       RL   +E +E     C   L + +++ 
Sbjct: 1366 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKC-ASLEKTKQRL 1424

Query: 972  PSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLD 1031
             + V++        N    A   K +   K  S+  +   ET+  LE      ASQ++  
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELE------ASQKESR 1478

Query: 1032 GLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKE 1091
             L+ E  K + + EE     E  + +    L  E +D  E  +   ++ +E +K +++ E
Sbjct: 1479 SLSTELFKVKNVYEESLDQLETLRRE-NKNLQQEISDLTEQIAEGGKQIHELEKIKKQVE 1537

Query: 1092 EDSEEEE---DDADSSLESPEENNPLRL 1116
            ++  E +   ++A++SLE  EE   LR+
Sbjct: 1538 QEKCEIQAALEEAEASLEH-EEGKILRI 1564



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 72/302 (23%), Positives = 132/302 (43%), Gaps = 25/302 (8%)

Query: 836  TDEEPAEPEDMER-FEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDL--- 891
            T +E A+ E   +  EE +V +L +   +Q   Q   +  +  +E+ E+L+  +  L   
Sbjct: 862  TKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAK 921

Query: 892  -KEELDACEREFKECMECLEKPMAPQNDKNEIK----ELQTKLRELQLQYQASMDEQGRL 946
             KE  +  E E +   E   K    +++ +E+K    +L+  L +++ +  A+ ++   L
Sbjct: 922  IKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 981

Query: 947  LVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDT 1006
                  L+  +    +E + L+E     + + + +    N+   A     ++V     D 
Sbjct: 982  TEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQV-----DD 1036

Query: 1007 SESDLETRKSLEVVLYYKASQRKLDG-LAKEEEKKEEMEEEKKQVKE--EAKEQCGDELV 1063
             E  LE  K L + L  + ++RKL+G L   +E   +ME +K+Q+ E  E KE     L+
Sbjct: 1037 LEGSLEQEKKLRMDL--ERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLI 1094

Query: 1064 AEPADPE------EAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLS 1117
            ++  D +      + K  E Q   EE  EE E E  S  + +   S L    E    RL 
Sbjct: 1095 SKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLE 1154

Query: 1118 ES 1119
            E+
Sbjct: 1155 EA 1156



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 35/127 (27%), Positives = 60/127 (47%), Gaps = 21/127 (16%)

Query: 1012 ETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEE-----------KKQVKEEA------ 1054
            ET K  E+    +  Q+  D LAK E K++E+EE+           + QV+ EA      
Sbjct: 847  ETEK--EMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904

Query: 1055 KEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPL 1114
            +E+C  E + +     EAK  E  E  EE++E   +    + + +D  S L+   ++  L
Sbjct: 905  EERC--EQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLEL 962

Query: 1115 RLSESKK 1121
             L++ +K
Sbjct: 963  TLAKVEK 969


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  122 bits (305), Expect = 3e-27
 Identities = 196/877 (22%), Positives = 371/877 (42%), Gaps = 116/877 (13%)

Query: 15   EEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQ------- 67
            E  EE E E   +E+E E +QK  +   ++  K   L    +ELE    ++ +       
Sbjct: 625  ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684

Query: 68   LVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISL 127
            L  +LE   +   Q ++++LEL+  +E  + AS + A++  +  ++L+ E   L++ + L
Sbjct: 685  LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN-KELESEKEQLKKGLEL 743

Query: 128  LE--HEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDM 185
            L+   +K   L+   Q L +    +Q   + +     + ES++  L+ +   +Q  LE  
Sbjct: 744  LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE-- 801

Query: 186  ERIRGDYEMEIASLRAEM---EMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRA 242
                   E++I+S R E    E KS E   S    D   L++E + LR++    +     
Sbjct: 802  -------ELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD---TT 851

Query: 243  LQESNSSLTGQLADLESERTQRATERWLQSQT-LSMTSAESQTSEM--DFLEPDPEMQLL 299
            L+E+N     ++ +LE E    + E  +  ++ + +   E +  E+          +  L
Sbjct: 852  LEENNV----KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907

Query: 300  RQQLRDAEEQMHGMKNKCQELCCELEE-------LQHHRQVSEEEQRRL----------- 341
            R+ L   + +   M N  ++L  ELE+       L H  Q +++ + +L           
Sbjct: 908  REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKK 967

Query: 342  QRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELL------------ 389
              E+K  +   L  +   S   N++L+  L T++K Y+  +  Q+E              
Sbjct: 968  SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED 1027

Query: 390  -KMQLQLQTELRQLKVMKSTLVE-------NQSEKELL-CRLQKLHLQHQNVTCEKEKLL 440
             K + + Q   R+L  +K  L+E        Q+EK+ L  +L++L  Q+ N+  +   L 
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1087

Query: 441  ERQQQLQEE---LQCHEAELQHLRDTVASFKES-NEKDTETHAQLQEMKQLYQASKDELE 496
             +   LQE+   LQ   A+LQ    T+ S   S   ++ +   Q   ++   ++   E E
Sbjct: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1147

Query: 497  RQKHMYDQLEQDLLLCQLELKELKAS--HPIPEDKGKCANKCDTLLSRLTELQEKYKASQ 554
              K +YD L +D    +L L E +AS    +    G   +    L     +L+++Y    
Sbjct: 1148 DLKSLYDSLIKDHEKLEL-LHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLL 1206

Query: 555  KEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCEL 614
            K+ GQL     E LE   ++++E+  L+ + H  T+      L  ++  L      L + 
Sbjct: 1207 KQKGQL-----EDLEKMLKVEQEKMLLENKNHE-TVAAEYKKLCGENDRLNHTYSQLLKE 1260

Query: 615  QLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENP---DDSKLAKSSK 671
              + Q   +  K L+ N      EQ  +  E  + KE + Q  + +    +  +L    K
Sbjct: 1261 TEVLQTDHKNLKSLLNNSKL---EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLK 1317

Query: 672  CNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQ 731
             N  ++++ L++Q+Q L +        + LL+Q     +E +     + +  ++++  L+
Sbjct: 1318 GNLEEENRHLLDQIQTLMLQ------NRTLLEQN----MESKDLFHVEQRQYIDKLNELR 1367

Query: 732  VQSPSIKMSLESYGKSYGSMVPSNE------NCRKTYDTTVDDNESYYKSYTSTQT---S 782
             Q   ++  +    K Y    P           RK   +  D N    KS T T T   S
Sbjct: 1368 RQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDS 1427

Query: 783  SKSFLK-----SYDSSTSASEAY--GKSYCTTSNSSI 812
            S+ FL+     S DSS+  S +   G++  T  +S++
Sbjct: 1428 SEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTM 1464



 Score =  113 bits (283), Expect = 9e-25
 Identities = 228/1066 (21%), Positives = 449/1066 (42%), Gaps = 166/1066 (15%)

Query: 13   LYEEEEEEEEEEEEVEE--EEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVA 70
            L++ E E + + +++EE  EE    +     S+  + H G  L +          +   +
Sbjct: 391  LHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ----------ISRTS 440

Query: 71   ELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEIS-LLE 129
            EL E  + +  HE + L    LL+ E      + +  TK +++L+  + S+    S +L+
Sbjct: 441  ELSEAPQKSLGHEVNELTSSRLLKLE-----MENQSLTKTVEELRTTVDSVEGNASKILK 495

Query: 130  HEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELED-MERI 188
             EKE++   + +++ + + EI   +Q+ ++          +L +DL + + +LE  +E +
Sbjct: 496  MEKENQ--RLSKKVEILENEIVQEKQSLQNCQ--------NLSKDLMKEKAQLEKTIETL 545

Query: 189  RGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNS 248
            R + E +I  L  E E  +   S     S  S           R   + +E + L ES  
Sbjct: 546  RENSERQIKILEQENEHLNQTVSSLRQRSQISA--------EARVKDIEKENKILHESIK 597

Query: 249  SLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEE 308
              + +L+ +E E+ Q   E  L+        AE   +E+  LE + E+          ++
Sbjct: 598  ETSSKLSKIEFEKRQIKKE--LEHYKEKGERAEELENELHHLEKENEL---------LQK 646

Query: 309  QMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELK 368
            ++  +K  C+++    E L+      E E R+L++ L   +N  L FQ      +N +L 
Sbjct: 647  KITNLKITCEKI----EALEQENSELERENRKLKKTLDSFKN--LTFQLESLEKENSQLD 700

Query: 369  SRLCTLQKKYDTSQDEQNELLKMQLQ---LQTELRQLKVMKSTLVENQSEKELL-CRLQK 424
                 L++  ++ +    ++ ++QL+   L++E  QLK     L  +  + E L    Q 
Sbjct: 701  EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 425  LHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEM 484
            L +++Q +    E   ++ QQL+ ELQ  E E Q L+  +   K S+++      QL++ 
Sbjct: 761  LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR----LEQLEKE 816

Query: 485  KQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLT 544
             +  +    +LE+ K   ++ E   L  Q E+K+      + E+  K  N          
Sbjct: 817  NKSLEQETSQLEKDKKQLEK-ENKRLRQQAEIKDTT----LEENNVKIGN---------- 861

Query: 545  ELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQEL 604
             L+++ K   KE+G +  E C       R++E + + +E + R T+ +         + L
Sbjct: 862  -LEKENKTLSKEIG-IYKESCV------RLKELEKENKELVKRATIDI---------KTL 904

Query: 605  LTKLEDLCELQLLYQGMQEEQKKLIQNQDCV-LKEQLEIHEELRRFKESHFQEVLENPDD 663
            +T  EDL   +L  Q M  + +KL    + + L ++  +H+E  +  +    ++LE+  +
Sbjct: 905  VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE--QSTDDSRYKLLESKLE 962

Query: 664  SKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLC 723
            S L KS +           E++ AL+   +      + L+QE    L+  K+    L+  
Sbjct: 963  STLKKSLEIKE--------EKIAALEARLEESTNYNQQLRQE----LKTVKKNYEALKQR 1010

Query: 724  LEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSS 783
             +E +++Q  SP I      + +       S E  R+     V D     +   +T  + 
Sbjct: 1011 QDEERMVQ-SSPPISGEDNKWERE------SQETTRELLK--VKDRLIEVERNNATLQAE 1061

Query: 784  KSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEP 843
            K  LK+                 T N+++         +     Q+  VS    +E    
Sbjct: 1062 KQALKTQLKQLE-----------TQNNNLQ--------AQILALQRQTVSL---QEQNTT 1099

Query: 844  EDMERFEEMVVKVLIKLQAVQAMYQISQE--EHSQLQEQMEKLLAKQKDLKEELDACERE 901
               +  +  V    +  Q+   M Q +Q   + S L+ + E ++ +++DLK   D+  ++
Sbjct: 1100 LQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD 1159

Query: 902  FKECMECLEKPMAPQND---------KNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQ 952
             ++ +E L +  A + +         K+  K L+ + R+L+ +Y   + ++G+L    E 
Sbjct: 1160 HEK-LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL----ED 1214

Query: 953  LEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLE 1012
            LE  L+  QE++  L  K    V     K   +N   N    ++ K T    +  ++D +
Sbjct: 1215 LEKMLKVEQEKM-LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET----EVLQTDHK 1269

Query: 1013 TRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQC 1058
              KSL  +   K  Q +L+    E  K +E  ++      +   QC
Sbjct: 1270 NLKSL--LNNSKLEQTRLEA---EFSKLKEQYQQLDITSTKLNNQC 1310



 Score =  112 bits (281), Expect = 2e-24
 Identities = 204/993 (20%), Positives = 413/993 (41%), Gaps = 118/993 (11%)

Query: 20   EEEEEEEVEEEEEQVQK--GGSVGSLSVNKHRGL-----SLTETELEELRAQVLQLVAEL 72
            E E+     E  E  QK  G  V  L+ ++   L     SLT+T +EELR  V  +    
Sbjct: 432  ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT-VEELRTTVDSVEGNA 490

Query: 73   EETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEK 132
             +  ++  +++  S +++ +LE+E +   Q  +      + L  E   L + I  L    
Sbjct: 491  SKILKMEKENQRLSKKVE-ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS 549

Query: 133  ESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDY 192
            E ++K +EQE       + SLRQ ++ SA   E+ +  ++++   +   +++        
Sbjct: 550  ERQIKILEQENEHLNQTVSSLRQRSQISA---EARVKDIEKENKILHESIKETSSKLSKI 606

Query: 193  EMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTG 252
            E E   ++ E+E              Y    E  +EL    H L +E   LQ+  ++L  
Sbjct: 607  EFEKRQIKKELE-------------HYKEKGERAEELENELHHLEKENELLQKKITNLKI 653

Query: 253  QLADLES-ERTQRATERWLQSQTLSMTSAESQTSEMDFLEPD-PEMQLLRQQLRDAEEQM 310
                +E+ E+     ER  +    ++ S ++ T +++ LE +  ++     +LR   E +
Sbjct: 654  TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713

Query: 311  HGMKNKCQELCCELEELQHHRQVSEEEQRRLQRE-LKCAQNEVLRFQTSHSVTQNEELKS 369
                 K  +L  E +EL+     SE+EQ +   E LK +  +  R + S+     E  + 
Sbjct: 714  KCASMKMAQLQLENKELE-----SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQR- 767

Query: 370  RLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC-RLQKLHLQ 428
                LQK  + S        K   QL++EL+ L++   TL +N  E ++   RL++L  +
Sbjct: 768  ----LQKTLENSN-------KKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816

Query: 429  HQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLY 488
            ++++  E  +L + ++QL++E +    + + ++DT  + +E+N K      + + + +  
Sbjct: 817  NKSLEQETSQLEKDKKQLEKENKRLRQQAE-IKDT--TLEENNVKIGNLEKENKTLSKEI 873

Query: 489  QASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQE 548
               K+   R K +  + ++ +    +++K L     + ED          L+S   + Q+
Sbjct: 874  GIYKESCVRLKELEKENKELVKRATIDIKTLVT---LRED----------LVSEKLKTQQ 920

Query: 549  KYKASQK---EMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELL 605
                 +K   E+ ++ + +  LL D++   + + +L E     TL   K  L +K +++ 
Sbjct: 921  MNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTL---KKSLEIKEEKIA 977

Query: 606  TKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSK 665
                 L E     Q +++E K + +N + + + Q    +E R  + S     +   D+  
Sbjct: 978  ALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ----DEERMVQSS---PPISGEDNKW 1030

Query: 666  LAKSSKCNRN----KQSKLLMEQMQA-LQVMYDAGQAKQELLQQEQGRLLEERKRLQADL 720
              +S +  R     K   + +E+  A LQ    A + + + L+ +   L  +   LQ   
Sbjct: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090

Query: 721  QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ 780
                E+   LQ Q+  +++   +      S++  N        +  ++NES  K     +
Sbjct: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1150

Query: 781  TSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP 840
            +   S +K ++      E     Y +  +   T K ++ +                    
Sbjct: 1151 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLE------------------ 1192

Query: 841  AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER 900
             E  D+E     ++K   +L+ ++ M ++ QE+     +  E + A+ K L  E D    
Sbjct: 1193 VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNH 1252

Query: 901  EFKECMECLEKPMAP--------QNDKNEIKELQTKLRELQLQYQ------ASMDEQGRL 946
             + + ++  E              N K E   L+ +  +L+ QYQ        ++ Q  L
Sbjct: 1253 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCEL 1312

Query: 947  LVVQEQLEGQLQCCQEELRQLREKRPSVVKEAR 979
            L    QL+G L   +EE R L ++  +++ + R
Sbjct: 1313 L---SQLKGNL---EEENRHLLDQIQTLMLQNR 1339



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 193/992 (19%), Positives = 409/992 (41%), Gaps = 103/992 (10%)

Query: 150  IQSLRQAAEDSATEHESDIASLQEDLCRMQ-NELEDMERIRGDYEMEIASLRAEMEMKSS 208
            IQ L    + +   H  ++   QE++  +Q  E+ DM +   D E  + ++   ++    
Sbjct: 145  IQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQ--EDIEPLLKNMALHLKRLID 202

Query: 209  EPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATER 268
            E        ++S    EL E R+  HFL         ++SS          +RT+     
Sbjct: 203  ERD------EHSETIIELSEERDGLHFL-------PHASSSAQSPCGSPGMKRTE----- 244

Query: 269  WLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQ 328
                Q LS+  A+++           +++ LRQ+L +  EQ+   K + +++  EL+ LQ
Sbjct: 245  --SRQHLSVELADAKA----------KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQ 292

Query: 329  HHRQ--VSEEEQRRLQR-ELKCAQNEVLRFQTSHS-VTQNEELKSRLCTLQKKYDTSQDE 384
                  +S+    R+ R EL   + + +R     S V++ +E    +   + + +  +++
Sbjct: 293  QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352

Query: 385  QNELLKMQLQLQTELRQLKVMKSTLVENQSEK-ELLCRLQKLHLQHQNVTCEKEKLLERQ 443
               LL+ +  L+ +L   +     L E + E  +L  +L  + ++      + E+L+E  
Sbjct: 353  NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412

Query: 444  QQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQL-QEMKQLYQASKDELERQKHMY 502
              L+   +    E  HL   +     ++E        L  E+ +L  +   +LE +    
Sbjct: 413  MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472

Query: 503  DQLEQDLLLCQLELKELKASHPIPEDK--GKCANKCDTLLSRLTELQEKYKASQKEMGQL 560
             +  ++ L   ++  E  AS  +  +K   + + K + L + + + ++  +  Q     L
Sbjct: 473  TKTVEE-LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531

Query: 561  QMEQCEL---LEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQ-ELLTKLEDL-CELQ 615
              E+ +L   +E  R   E Q ++ E+ +   L    S L  +SQ     +++D+  E +
Sbjct: 532  MKEKAQLEKTIETLRENSERQIKILEQENE-HLNQTVSSLRQRSQISAEARVKDIEKENK 590

Query: 616  LLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKE-SHFQEVLENPDDSKLAKSSKCNR 674
            +L++ ++E   KL +    +  E+ +I +EL  +KE     E LEN            + 
Sbjct: 591  ILHESIKETSSKLSK----IEFEKRQIKKELEHYKEKGERAEELEN---------ELHHL 637

Query: 675  NKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQS 734
             K+++LL +++  L++  +    K E L+QE   L  E ++L+  L              
Sbjct: 638  EKENELLQKKITNLKITCE----KIEALEQENSELERENRKLKKTLD-----------SF 682

Query: 735  PSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSST 794
             ++   LES  K    +   N   R+     V+  +         Q  +K      +   
Sbjct: 683  KNLTFQLESLEKENSQLDEENLELRR----NVESLKCASMKMAQLQLENKELESEKEQLK 738

Query: 795  SASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPE--DMERFEEM 852
               E    S+  T    ++Y+   G    +   QK+  +S    +  E E  D+E   + 
Sbjct: 739  KGLELLKASFKKTERLEVSYQ---GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795

Query: 853  VVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKP 912
            + K L +L+      +  ++E+  L+++  +L   +K L++E     +  ++  E  +  
Sbjct: 796  LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE----NKRLRQQAEIKDTT 851

Query: 913  MAPQNDK--NEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
            +   N K  N  KE +T  +E+ +  ++ +    RL  ++++ +  ++    +++ L   
Sbjct: 852  LEENNVKIGNLEKENKTLSKEIGIYKESCV----RLKELEKENKELVKRATIDIKTLVTL 907

Query: 971  RPSVVKE-ARGKNANKNMNKNAN-----GVKMKKVTKPCSDTSESDLETRKSLEVVLYYK 1024
            R  +V E  + +  N ++ K  +     G+  +++      T +S  +  +S       K
Sbjct: 908  REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKK 967

Query: 1025 ASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKE-QCGDELVAEPADPEEAKSTEDQEENEE 1083
            + + K + +A  E + EE     +Q+++E K  +   E + +  D E    +      E+
Sbjct: 968  SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED 1027

Query: 1084 DKEEEEKEEDSEEEEDDADSSLESPEENNPLR 1115
            +K E E +E + E     D  +E    N  L+
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNNATLQ 1059


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score =  122 bits (305), Expect = 3e-27
 Identities = 241/1195 (20%), Positives = 486/1195 (40%), Gaps = 152/1195 (12%)

Query: 7    EVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVL 66
            +VL  A  E +++ +E   EV    + +    S+ S         S  ET+ E L+    
Sbjct: 363  DVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLES---------SAAETQEEMLQV--- 410

Query: 67   QLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEIS 126
                 L+E   L GQ E  SLE    L+++    AQ A + TK   Q++    S + + S
Sbjct: 411  -----LKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDS 465

Query: 127  LLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDME 186
            L    +   LK+   +L  A  ++Q++ +A   S     +D+   +E   R+  ++EDM+
Sbjct: 466  L--SSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQ 523

Query: 187  RIRGDYEMEIASLRAEM-----EMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYR 241
            R     +  +  LR +M     +++  +   +   S     Q E+  L+    +  ++  
Sbjct: 524  RSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLA 583

Query: 242  ALQESNSSLTGQLADLE-SERTQRATERWLQSQTLSMT-----------------SAESQ 283
              QE+   L G++A ++  + TQ      L+ + +S++                 +A+ Q
Sbjct: 584  LAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQ 643

Query: 284  TSEMDFLEPDPEMQ-------LLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEE 336
              E D L+ +           ++ + L+   E+  G + + Q +      L+  +Q+ + 
Sbjct: 644  GIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLE--QQLEQV 701

Query: 337  EQRRLQR--ELKCAQNEVLRFQTSHSVTQNEELKSR---LCTLQKKYDTSQDEQNELLKM 391
            +   LQR  +L+  Q E L      ++TQ E L+SR   L  LQ  YD  Q    EL   
Sbjct: 702  KLTLLQRDQQLEALQQEHLDLMKQLTLTQ-EALQSREQSLDALQTHYDELQARLGELQGE 760

Query: 392  QLQLQTELRQLK----VMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQ 447
                +  +  L+    ++++ L   +S KE L R  +   + +  T E  + LE+   L+
Sbjct: 761  AASREDTICLLQNEKIILEAALQAAKSGKEELDRGAR---RLEEGTEETSETLEK---LR 814

Query: 448  EELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQ---ASKDELERQKHMYDQ 504
            EEL     +++HL+   A+ K+  +K  E   Q + M + Y+    SKD+L        +
Sbjct: 815  EELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQL------ISE 868

Query: 505  LEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQ 564
            L+        ELKEL+        + + A   +  LSRL           +E+ Q++   
Sbjct: 869  LKATRKRLDSELKELRQELMQVHGEKRTA---EAELSRL----------HREVAQVRQHM 915

Query: 565  CELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTK-LEDLCELQLLYQGMQE 623
             +L    +  Q+E+ +++  L  L     +   + ++ E L K +E+L   Q   + + E
Sbjct: 916  ADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEEL--QQEARKAITE 973

Query: 624  EQKKLIQNQDCVLKEQLEIHEELRRFKES------HFQEVL--ENPDDSKLAKSSKCNRN 675
            +++K+ +    +   Q E+  + + ++ +        QE L  +   D++L +      +
Sbjct: 974  QKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGS 1033

Query: 676  KQSKL-LMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQS 734
              S L L E++QAL+    A    + LL++E          LQ  + L  +E++  + + 
Sbjct: 1034 SDSSLALHERIQALEAELQAVSHSKTLLEKE----------LQEVIALTSQELEESREKV 1083

Query: 735  PSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSST 794
              ++  L+   + +   +   E   K     ++    + K   +    S + L+ ++S  
Sbjct: 1084 LELEDELQE-SRGFRKKIKRLEESNKKLALELE----HEKGKLTGLGQSNAALREHNSIL 1138

Query: 795  SASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVV 854
                A  K        ++  +         D   K  V +       E E +   +E V 
Sbjct: 1139 ET--ALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVA 1196

Query: 855  KVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACE-REFKECMECLEKPM 913
               ++    +  ++ +  E S+++++++      + L+ E D  + RE K   E  +   
Sbjct: 1197 AAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQ--- 1253

Query: 914  APQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPS 973
                 + E+ E + +L+ LQ Q    + +Q       E L+ ++   + E++ L+++   
Sbjct: 1254 ----FQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD- 1308

Query: 974  VVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGL 1033
             + E +G+   + + +    VK +       + ++ DL   +  + +L  K S+ K +  
Sbjct: 1309 -LTEQQGRKELEGLQQLLQNVKSE------LEMAQEDLSMTQKDKFMLQAKVSELKNNMK 1361

Query: 1034 AKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADP-------------EEAKSTEDQEE 1080
               ++ ++   + ++   +  KE  G+   + PA P             EE         
Sbjct: 1362 TLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVS 1421

Query: 1081 NEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPL 1135
             E  K      +  ++E D    SL+   E + L + ES  SS TP  P  + P+
Sbjct: 1422 KEPLKNLNSCLQQLKQEMD----SLQRQMEEHALTVHES-LSSWTPLEPATASPV 1471



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 147/647 (22%), Positives = 258/647 (39%), Gaps = 104/647 (16%)

Query: 3    AMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELR 62
            A   + L+  L    +  + E +E+ +E  QV             H      E EL  L 
Sbjct: 859  ATSKDQLISELKATRKRLDSELKELRQELMQV-------------HGEKRTAEAELSRLH 905

Query: 63   ---AQVLQLVAELEETRELAGQHEDDSLE--LQGLLEDER--LASAQQAEVFTKQIQQLQ 115
               AQV Q +A+LE   + A Q E D +E  LQ L  D+   +A  +  E   KQI++LQ
Sbjct: 906  REVAQVRQHMADLEGHLQSA-QKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQ 964

Query: 116  GE-----------LRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATE- 163
             E           +R L  +++  + E +++ K  E  + +    +Q    A E +  E 
Sbjct: 965  QEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAEL 1024

Query: 164  ---------HESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSL 214
                      +S +A L E +  ++ EL+ +   +   E E+  + A    +  E    +
Sbjct: 1025 GQLRAQGGSSDSSLA-LHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKV 1083

Query: 215  GLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQT 274
                   L++ELQE R       ++ + L+ESN  L  +L   + + T          + 
Sbjct: 1084 -----LELEDELQESRG----FRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREH 1134

Query: 275  LSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEE-------L 327
             S+        E D ++ + ++Q + Q+  + + QM   K+  Q L   LE+       L
Sbjct: 1135 NSILETALAKREADLVQLNLQVQAVLQRKEEEDRQM---KHLVQALQASLEKEKEKVNSL 1191

Query: 328  QHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQ-- 385
            +     ++ E    +R  K A  E+   +        +EL+++   +QK    + D Q  
Sbjct: 1192 KEQVAAAKVEAGHNRRHFKAASLELSEVK--------KELQAKEHLVQKLQAEADDLQIR 1243

Query: 386  -----NELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLL 440
                  E+ + Q +L     QL++++  L E  S++ +    Q++      V  ++ ++ 
Sbjct: 1244 EGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPV--GNQEMENLKWEVDQKEREIQ 1301

Query: 441  ERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKH 500
              +QQL    Q    EL+ L+  + + K   E   E  +  Q+ K + QA   EL+    
Sbjct: 1302 SLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMK 1361

Query: 501  MYDQLEQDLLLCQLELKELKASHPIPEDKGKCANK----------CDTLLSRLTELQEKY 550
               Q  Q L   +L+L+   A+    E KG+ ++           C    S L EL    
Sbjct: 1362 TLLQQNQQL---KLDLRR-GAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPP 1417

Query: 551  KASQKE--------MGQLQMEQCELLEDQRRMQEEQGQLQEELHRLT 589
             A  KE        + QL+ E   L   QR+M+E    + E L   T
Sbjct: 1418 PAVSKEPLKNLNSCLQQLKQEMDSL---QRQMEEHALTVHESLSSWT 1461


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.123    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,794,639
Number of Sequences: 37866
Number of extensions: 2306274
Number of successful extensions: 95734
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1185
Number of HSP's successfully gapped in prelim test: 1731
Number of HSP's that attempted gapping in prelim test: 21449
Number of HSP's gapped (non-prelim): 33407
length of query: 1154
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1041
effective length of database: 13,968,660
effective search space: 14541375060
effective search space used: 14541375060
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.