BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|11545839 protease, serine, 22 [Homo sapiens] (317 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|11545839 protease, serine, 22 [Homo sapiens] 667 0.0 gi|13994276 marapsin [Homo sapiens] 285 3e-77 gi|117956391 protease, serine, 33 [Homo sapiens] 244 1e-64 gi|4506153 prostasin preproprotein [Homo sapiens] 233 2e-61 gi|156938340 transmembrane tryptase preproprotein [Homo sapiens] 218 6e-57 gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 209 2e-54 gi|21614531 testisin isoform 2 [Homo sapiens] 207 1e-53 gi|58218970 protease, serine, 36 [Homo sapiens] 204 8e-53 gi|5803197 testisin isoform 1 [Homo sapiens] 202 3e-52 gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens] 202 4e-52 gi|68508970 tryptase beta 2 precursor [Homo sapiens] 199 3e-51 gi|33667063 transmembrane protease, serine 9 [Homo sapiens] 189 2e-48 gi|148806900 epidermis-specific serine protease-like protein [Ho... 189 3e-48 gi|205360905 testis-specific serine protease 1 [Homo sapiens] 186 3e-47 gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 184 9e-47 gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 182 3e-46 gi|4503627 coagulation factor XI precursor [Homo sapiens] 182 4e-46 gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 181 6e-46 gi|34098976 marapsin 2 [Homo sapiens] 180 1e-45 gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa... 178 5e-45 gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap... 178 5e-45 gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 176 2e-44 gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 176 2e-44 gi|21614533 testisin isoform 3 [Homo sapiens] 176 3e-44 gi|194018492 transmembrane protease, serine 11F [Homo sapiens] 173 2e-43 gi|187761337 transmembrane protease, serine 11B [Homo sapiens] 172 5e-43 gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens] 171 6e-43 gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo ... 171 6e-43 gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo ... 171 6e-43 gi|33695155 hepsin [Homo sapiens] 170 2e-42 >gi|11545839 protease, serine, 22 [Homo sapiens] Length = 317 Score = 667 bits (1720), Expect = 0.0 Identities = 317/317 (100%), Positives = 317/317 (100%) Query: 1 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE 60 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE Sbjct: 1 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE 60 Query: 61 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK 120 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK Sbjct: 61 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK 120 Query: 121 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW 180 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW Sbjct: 121 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW 180 Query: 181 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLG 240 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLG Sbjct: 181 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLG 240 Query: 241 DSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQG 300 DSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQG Sbjct: 241 DSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQG 300 Query: 301 GGALRAPSQGSGAAARS 317 GGALRAPSQGSGAAARS Sbjct: 301 GGALRAPSQGSGAAARS 317 >gi|13994276 marapsin [Homo sapiens] Length = 290 Score = 285 bits (730), Expect = 3e-77 Identities = 139/285 (48%), Positives = 188/285 (65%), Gaps = 10/285 (3%) Query: 21 LLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLL 80 LLLL + R ACG+P+ LNR+VGG+D+ + EWPW VSIQ+NG+H C GSL+ Sbjct: 10 LLLLC----FGSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLI 65 Query: 81 TSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACA 140 +WV+TAAHCF+ N ++ L+ VLLGA QL PG + V VE +P+Y + A Sbjct: 66 AEQWVLTAAHCFR-NTSETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASS-A 123 Query: 141 DIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKV 200 D+ALV LE + F+ +LP+CLPD S+ +CW++GWGS + LP P+ LQKL V Sbjct: 124 DVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAV 183 Query: 201 PIIDSEVCSHLYWRGAGQG----PITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLL 256 PIID+ C+ LY + G I DMLCAG+ EG++DAC GDSGGPL+C V +WL Sbjct: 184 PIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQ 243 Query: 257 AGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQGG 301 AG+ISWGEGCA +NRPGVYI ++AH +W+ +I+ +Q + GG Sbjct: 244 AGVISWGEGCARQNRPGVYIRVTAHHNWIHRIIPKLQFQPARLGG 288 >gi|117956391 protease, serine, 33 [Homo sapiens] Length = 280 Score = 244 bits (622), Expect = 1e-64 Identities = 118/251 (47%), Positives = 159/251 (63%), Gaps = 6/251 (2%) Query: 40 ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99 ACG+P+ +R+VGG D D EWPW SIQ G H C GSL+ +WV+TAAHCF P Sbjct: 27 ACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRRA-LP 85 Query: 100 YLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLP 159 + V LGA +LG+ R+ V V V P YS ++GA D+AL++L R + S RV P Sbjct: 86 AEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYS-EDGARGDLALLQLRRPVPLSARVQP 144 Query: 160 ICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGA--- 216 +CLP PP T C ++GWGS++ GVPLP + LQ ++VP++DS C LY GA Sbjct: 145 VCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVP 204 Query: 217 -GQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVY 275 + + LCAGY +G +DAC GDSGGPL C G+W+L G++SWG+GCA NRPGVY Sbjct: 205 QAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVY 264 Query: 276 ISLSAHRSWVE 286 S++ + W++ Sbjct: 265 TSVATYSPWIQ 275 >gi|4506153 prostasin preproprotein [Homo sapiens] Length = 343 Score = 233 bits (594), Expect = 2e-61 Identities = 128/292 (43%), Positives = 169/292 (57%), Gaps = 13/292 (4%) Query: 10 LGGGCLGTFTSLL---LLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVS 66 LG G LG LL LL S A P CG Q R+ GG + +WPW VS Sbjct: 7 LGPGQLGAVAILLYLGLLRSGTGAEGAEAP----CGVAPQA-RITGGSSAVAGQWPWQVS 61 Query: 67 IQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWV 126 I G H C GSL++ +WV++AAHCF +K + V LGA QL + ++ + + Sbjct: 62 ITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKE-AYEVKLGAHQLDSYSEDAKVSTLKDI 120 Query: 127 EPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDG 186 PHP Y +EG+ DIAL++L R I FS + PICLP A+ P HC ++GWG + Sbjct: 121 IPHPSYL-QEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPS 179 Query: 187 VPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGP---ITEDMLCAGYLEGERDACLGDSG 243 V L P+ LQ+L+VP+I E C+ LY A + EDM+CAGY+EG +DAC GDSG Sbjct: 180 VSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSG 239 Query: 244 GPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLR 295 GPL C V+G W L GI+SWG+ C RNRPGVY S++ SW++ V +Q R Sbjct: 240 GPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPR 291 >gi|156938340 transmembrane tryptase preproprotein [Homo sapiens] Length = 321 Score = 218 bits (555), Expect = 6e-57 Identities = 117/276 (42%), Positives = 160/276 (57%), Gaps = 14/276 (5%) Query: 15 LGTFTSLLLLASTAILNAARIPVPPACGKPQQLN---RVVGGEDSTDSEWPWIVSIQKNG 71 LG LLLLA + + + P CG+PQ + R+VGG + WPW S++ Sbjct: 3 LGACGLLLLLAVPGV---SLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRR 59 Query: 72 THHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPV 131 H C GSLL+ +WV+TAAHCF +LN + V LG ++ S V + H Sbjct: 60 VHVCGGSLLSPQWVLTAAHCFSGSLNSSD-YQVHLGELEITLSPHFST---VRQIILHSS 115 Query: 132 YSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPH 191 S + G DIALV L + S R+LP+CLP+AS P CW++GWG ++G PLP Sbjct: 116 PSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPP 175 Query: 192 PQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVD 251 P +L+++KV ++D+E C Y G G + DMLCA G DAC DSGGPL+CQV+ Sbjct: 176 PYSLREVKVSVVDTETCRRDY-PGPGGSILQPDMLCA---RGPGDACQDDSGGPLVCQVN 231 Query: 252 GAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEK 287 GAW+ AGI+SWGEGC NRPGVY + A+ +W+ + Sbjct: 232 GAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRR 267 >gi|23957702 transmembrane protease, serine 6 [Homo sapiens] Length = 811 Score = 209 bits (533), Expect = 2e-54 Identities = 107/253 (42%), Positives = 156/253 (61%), Gaps = 14/253 (5%) Query: 41 CGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCF-KDNLNKP 99 CG +R+VGG S++ EWPW S+Q G H C G+L+ RWVITAAHCF +D++ Sbjct: 568 CGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMAST 627 Query: 100 YLFSVLLG-AWQLGN-PGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERV 157 L++V LG WQ PG S KV + P Y ++ D+AL++L+ + S V Sbjct: 628 VLWTVFLGKVWQNSRWPGEVSFKVSRLLLHP---YHEEDSHDYDVALLQLDHPVVRSAAV 684 Query: 158 LPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAG 217 P+CLP S P HCWI+GWG++++G P+ + LQK+ V +I ++CS +Y Sbjct: 685 RPVCLPARSHFFEPGLHCWITGWGALREGGPISN--ALQKVDVQLIPQDLCSEVY----- 737 Query: 218 QGPITEDMLCAGYLEGERDACLGDSGGPLMCQ-VDGAWLLAGIISWGEGCAERNRPGVYI 276 + +T MLCAGY +G++DAC GDSGGPL+C+ + G W LAG++SWG GC N GVY Sbjct: 738 RYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYT 797 Query: 277 SLSAHRSWVEKIV 289 ++ SW++++V Sbjct: 798 RITGVISWIQQVV 810 >gi|21614531 testisin isoform 2 [Homo sapiens] Length = 312 Score = 207 bits (526), Expect = 1e-53 Identities = 106/287 (36%), Positives = 162/287 (56%), Gaps = 15/287 (5%) Query: 13 GCLGTFTSLLLLASTAIL---NAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQK 69 G G LLLA + + P+ CG+ +R+VGGED+ WPW S++ Sbjct: 2 GARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRL 61 Query: 70 NGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGA-------WQLGNPGSRSQKVG 122 +H C SLL+ RW +TAAHCF+ +L+ P + V G W L +R V Sbjct: 62 WDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTR-YFVS 120 Query: 123 VAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGS 182 ++ P + + DIALV+L + +++ + PICL ++ T CW++GWG Sbjct: 121 NIYLSPR----YLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGY 176 Query: 183 IQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDS 242 I++ LP P TLQ+++V II++ +C+HL+ + + + I DM+CAG +G +DAC GDS Sbjct: 177 IKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDS 236 Query: 243 GGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 289 GGPL C +G W G++SWG GC NRPGVY ++S H W++K++ Sbjct: 237 GGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM 283 >gi|58218970 protease, serine, 36 [Homo sapiens] Length = 855 Score = 204 bits (519), Expect = 8e-53 Identities = 107/259 (41%), Positives = 143/259 (55%), Gaps = 12/259 (4%) Query: 41 CGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDN--LNK 98 CG+P+ R+VGG ++ WPW VS+ G H C GSL+ WV++AAHCF N L Sbjct: 38 CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97 Query: 99 PYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVL 158 +SVLLG P + VA + YS E AD+AL+RL V Sbjct: 98 AAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELG-ADLALLRLASPASLGPAVW 156 Query: 159 PICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQ 218 P+CLP AS T CW +GWG +Q+ PLP P LQ++++ ++ C LY + Sbjct: 157 PVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLY---SQP 213 Query: 219 GP------ITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRP 272 GP I MLCAGY EG RD C GDSGGPL+C+ G W AGI S+G GC RNRP Sbjct: 214 GPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRP 273 Query: 273 GVYISLSAHRSWVEKIVQG 291 GV+ +++ + +W+ + V G Sbjct: 274 GVFTAVATYEAWIREQVMG 292 Score = 111 bits (278), Expect = 7e-25 Identities = 76/246 (30%), Positives = 109/246 (44%), Gaps = 16/246 (6%) Query: 53 GEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLG 112 G+ WPW + G+ C G+L++ WV+ A CF D N L AW++ Sbjct: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDP-NSSDSPPRDLDAWRVL 384 Query: 113 NPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPN 172 P SR + VA + H SW +D+AL++L + S P+CLP + P Sbjct: 385 LP-SRPRAERVARLVQHENASWDN--ASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPG 441 Query: 173 THCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITED---MLCAG 229 + C ++ WG G P P L L+ ++ C LY R P+ D LC Sbjct: 442 SRCRLARWGR---GEPALGPGAL--LEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPA 496 Query: 230 YLEGER-DACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKI 288 Y E E +C DS L+CQ +G W LAGI + GC RP + L H W+ + Sbjct: 497 YQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCL---RPRAFFPLQTHGPWISHV 553 Query: 289 VQGVQL 294 +G L Sbjct: 554 TRGAYL 559 Score = 98.2 bits (243), Expect = 8e-21 Identities = 67/233 (28%), Positives = 103/233 (44%), Gaps = 30/233 (12%) Query: 61 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCF--KDNLNKPYLFSVLLGAWQLGNP-GSR 117 WPW+ + G C G LL WV+ A HC + PY+ L A P G + Sbjct: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660 Query: 118 SQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWI 177 ++ ++ P + G +AL+ L ++ S LPICL A I PP CW+ Sbjct: 661 VSRLVISIRLPQHL-----GLRPPLALLELSSRVEPSPSALPICLHPAGI--PPGASCWV 713 Query: 178 SGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDA 237 GW QD VP+ V I+ +C LY QG + LC Y EG+ + Sbjct: 714 LGWKEPQDRVPV-------AAAVSILTQRICDCLY-----QGILPPGTLCVLYAEGQENR 761 Query: 238 CLGDSGGPLMCQV-DGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 289 C S PL+CQ+ +G+W+L G+ A + ++ ++ +W+ + V Sbjct: 762 CEMTSAPPLLCQMTEGSWILVGM-------AVQGSRELFAAIGPEEAWISQTV 807 >gi|5803197 testisin isoform 1 [Homo sapiens] Length = 314 Score = 202 bits (514), Expect = 3e-52 Identities = 106/289 (36%), Positives = 162/289 (56%), Gaps = 17/289 (5%) Query: 13 GCLGTFTSLLLLASTAIL---NAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQK 69 G G LLLA + + P+ CG+ +R+VGGED+ WPW S++ Sbjct: 2 GARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRL 61 Query: 70 NGTHHCAGSLLTSRWVITAAHCFK--DNLNKPYLFSVLLGA-------WQLGNPGSRSQK 120 +H C SLL+ RW +TAAHCF+ +L+ P + V G W L +R Sbjct: 62 WDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTR-YF 120 Query: 121 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW 180 V ++ P + + DIALV+L + +++ + PICL ++ T CW++GW Sbjct: 121 VSNIYLSPR----YLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGW 176 Query: 181 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLG 240 G I++ LP P TLQ+++V II++ +C+HL+ + + + I DM+CAG +G +DAC G Sbjct: 177 GYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFG 236 Query: 241 DSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 289 DSGGPL C +G W G++SWG GC NRPGVY ++S H W++K++ Sbjct: 237 DSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM 285 >gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens] Length = 275 Score = 202 bits (513), Expect = 4e-52 Identities = 110/277 (39%), Positives = 161/277 (58%), Gaps = 15/277 (5%) Query: 20 SLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGT---HHCA 76 +LLLLA + A+R PA G+ Q +VGG+++ S+WPW VS++ +G H C Sbjct: 3 NLLLLALPVL--ASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG 60 Query: 77 GSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKE 136 GSL+ +WV+TAAHC ++ V L L + Q + V+ + HP + + Sbjct: 61 GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYY---QDQLLPVSRIIVHPQF-YTA 116 Query: 137 GACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQ 196 ADIAL+ LE + S V + LP AS PP CW++GWG + + LP P L+ Sbjct: 117 QIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLK 176 Query: 197 KLKVPIIDSEVCSHLYWRGAGQGP----ITEDMLCAGYLEGERDACLGDSGGPLMCQVDG 252 ++KVPI+++ +C Y GA G + +DMLCAG RD+C GDSGGPL+C+V+G Sbjct: 177 QVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAG--NTRRDSCQGDSGGPLVCKVNG 234 Query: 253 AWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 289 WL AG++SWGEGCA+ NRPG+Y ++ + W+ V Sbjct: 235 TWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYV 271 >gi|68508970 tryptase beta 2 precursor [Homo sapiens] Length = 275 Score = 199 bits (506), Expect = 3e-51 Identities = 109/277 (39%), Positives = 160/277 (57%), Gaps = 15/277 (5%) Query: 20 SLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQ---KNGTHHCA 76 +LLLLA + A+R PA G+ Q +VGG+++ S+WPW VS++ + H C Sbjct: 3 NLLLLALPVL--ASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVRDRYWMHFCG 60 Query: 77 GSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKE 136 GSL+ +WV+TAAHC ++ V L L + Q + V+ + HP + + Sbjct: 61 GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYY---QDQLLPVSRIIVHPQF-YTA 116 Query: 137 GACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQ 196 ADIAL+ LE + S V + LP AS PP CW++GWG + + LP P L+ Sbjct: 117 QIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLK 176 Query: 197 KLKVPIIDSEVCSHLYWRGAGQGP----ITEDMLCAGYLEGERDACLGDSGGPLMCQVDG 252 ++KVPI+++ +C Y GA G + +DMLCAG RD+C GDSGGPL+C+V+G Sbjct: 177 QVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAG--NTRRDSCQGDSGGPLVCKVNG 234 Query: 253 AWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 289 WL AG++SWGEGCA+ NRPG+Y ++ + W+ V Sbjct: 235 TWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYV 271 >gi|33667063 transmembrane protease, serine 9 [Homo sapiens] Length = 1059 Score = 189 bits (481), Expect = 2e-48 Identities = 91/238 (38%), Positives = 145/238 (60%), Gaps = 9/238 (3%) Query: 49 RVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGA 108 R+VGG +++ E+PW S+++N H C +++ +RW+++AAHCF + P + +GA Sbjct: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNE-FQDPTKWVAYVGA 260 Query: 109 WQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIH 168 L + + + V + HP+Y+ + A D+A++ L + F + P+CLP A+ Sbjct: 261 TYLSGSEASTVRAQVVQIVKHPLYN-ADTADFDVAVLELTSPLPFGRHIQPVCLPAATHI 319 Query: 169 LPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCA 228 PP+ C ISGWG +++ L P+ LQK V ++D +C+ LY +T+ M+CA Sbjct: 320 FPPSKKCLISGWGYLKEDF-LVKPEVLQKATVELLDQALCASLYGHS-----LTDRMVCA 373 Query: 229 GYLEGERDACLGDSGGPLMC-QVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWV 285 GYL+G+ D+C GDSGGPL+C + G + LAGI+SWG GCAE RPGVY ++ R W+ Sbjct: 374 GYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWI 431 Score = 181 bits (459), Expect = 8e-46 Identities = 107/285 (37%), Positives = 157/285 (55%), Gaps = 15/285 (5%) Query: 15 LGTFTSLLLLASTAILNAARIPVPPACG-KP--QQLNRVVGGEDSTDSEWPWIVSIQKNG 71 + T T + ST L+ +P CG +P ++ RVVGG + E PW VS+++ Sbjct: 466 VSTPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGS 525 Query: 72 THHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPV 131 H C +++ RW+++AAHCF N K LG L G K+G+ V HP+ Sbjct: 526 RHFCGATVVGDRWLLSAAHCF--NHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPL 583 Query: 132 YSWKEGAC-ADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLP 190 Y+ G D+A++ L + F++ + P+CLP A P C ISGWG+ Q+G Sbjct: 584 YN--PGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEG-NAT 640 Query: 191 HPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMC-Q 249 P+ LQK V IID + CS LY +T+ M+CAG+LEG+ D+C GDSGGPL C + Sbjct: 641 KPELLQKASVGIIDQKTCSVLY-----NFSLTDRMICAGFLEGKVDSCQGDSGGPLACEE 695 Query: 250 VDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQL 294 G + LAGI+SWG GCA+ +PGVY ++ + W+ +I+ L Sbjct: 696 APGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMSSQPL 740 Score = 168 bits (426), Expect = 5e-42 Identities = 96/255 (37%), Positives = 138/255 (54%), Gaps = 14/255 (5%) Query: 39 PACG-KPQQLNRVVGGEDSTDSEWPWIVSIQ-KNGTHHCAGSLLTSRWVITAAHCFKDNL 96 P CG P L R+VGG + EWPW VS+ + H C L+ RW+++AAHCF D Sbjct: 815 PDCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCF-DVY 873 Query: 97 NKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSER 156 P ++ LG L G+ Q VA + HP Y+ D+AL+ L ++ S Sbjct: 874 GDPKQWAAFLGTPFLS--GAEGQLERVARIYKHPFYNLYT-LDYDVALLELAGPVRRSRL 930 Query: 157 VLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGA 216 V PICLP+ + P T C I+GWGS+++G + + LQK V ++ + C Y Sbjct: 931 VRPICLPEPAPRPPDGTRCVITGWGSVREGGSM--ARQLQKAAVRLLSEQTCRRFY---- 984 Query: 217 GQGPITEDMLCAGYLEGERDACLGDSGGPLMC-QVDGAWLLAGIISWGEGCAERNRPGVY 275 I+ MLCAG+ +G D+C GD+GGPL C + G W+L G+ SWG GC + PGVY Sbjct: 985 -PVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVY 1043 Query: 276 ISLSAHRSWVEKIVQ 290 ++A R W+ + +Q Sbjct: 1044 TRVAAVRGWIGQHIQ 1058 >gi|148806900 epidermis-specific serine protease-like protein [Homo sapiens] Length = 328 Score = 189 bits (480), Expect = 3e-48 Identities = 100/282 (35%), Positives = 155/282 (54%), Gaps = 25/282 (8%) Query: 13 GCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGT 72 GC FT LLLL + CG+P +RVVGG+D+ WPW VS+ + Sbjct: 5 GC--AFTLLLLLGISV------------CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHN 50 Query: 73 HHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVY 132 C GSL++ R ++TAAHC + + ++V LG+ +G+ R K V+ + HP Y Sbjct: 51 FICGGSLVSERLILTAAHCIQPTWTT-FSYTVWLGSITVGDSRKRV-KYYVSKIVIHPKY 108 Query: 133 SWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHP 192 + AD+AL++L + F+ +LPICLP + L CW++GWG +++ + Sbjct: 109 ---QDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYH 165 Query: 193 QTLQKLKVPIIDSEVCSHLY-----WRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLM 247 LQ+ +VPIID + C LY + A + I ED +CAG + +D+C GDSGGPL Sbjct: 166 SALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLS 225 Query: 248 CQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 289 C +DG W+ G++SWG C ++ PGVY ++ ++ W+ + Sbjct: 226 CHIDGVWIQTGVVSWGLECG-KSLPGVYTNVIYYQKWINATI 266 >gi|205360905 testis-specific serine protease 1 [Homo sapiens] Length = 318 Score = 186 bits (471), Expect = 3e-47 Identities = 96/258 (37%), Positives = 144/258 (55%), Gaps = 14/258 (5%) Query: 40 ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99 ACG + V GG +S WPW S++ H C GSLL+ RWV++AAHCF+ + P Sbjct: 45 ACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY-P 103 Query: 100 YLFSVLLGA-------WQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQ 152 ++V LG W L SR KV V P + + DIAL+RL S+ Sbjct: 104 SEWTVQLGELTSRPTPWNLRAYSSR-YKVQDIIVNPDALGVLRN----DIALLRLASSVT 158 Query: 153 FSERVLPICLPDASIHLPPNTHCWISGWGSIQ-DGVPLPHPQTLQKLKVPIIDSEVCSHL 211 ++ + PIC+ ++ + CW++GWG I G PLP P L++ +V I+++ C++L Sbjct: 159 YNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYL 218 Query: 212 YWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNR 271 + + + + I + M CAG +G D C GDSGGPL+C DG W GI+SWG C + NR Sbjct: 219 FEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNR 278 Query: 272 PGVYISLSAHRSWVEKIV 289 PGVY ++S + W+ +++ Sbjct: 279 PGVYTNISVYFHWIRRVM 296 >gi|170932492 transmembrane protease, serine 5 [Homo sapiens] Length = 457 Score = 184 bits (467), Expect = 9e-47 Identities = 98/253 (38%), Positives = 133/253 (52%), Gaps = 11/253 (4%) Query: 41 CGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPY 100 CG +R+VGG+ WPW S+ H C GS+L RWV+TAAHC + Sbjct: 209 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMH-SFRLAR 267 Query: 101 LFSVLLGAWQLGNPGSRS-QKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLP 159 L S + A + + R Q V + PHP+YS + D+AL+RL+ ++ FS+ V Sbjct: 268 LSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYS-AQNHDYDVALLRLQTALNFSDTVGA 326 Query: 160 ICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVC--SHLYWRGAG 217 +CLP H P + CW+SGWG LQ VP+ +++C S +Y Sbjct: 327 VCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDM-LQDTVVPLFSTQLCNSSCVY----- 380 Query: 218 QGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYIS 277 G +T MLCAGYL+G DAC GDSGGPL+C W L G++SWG GCAE N PGVY Sbjct: 381 SGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAK 440 Query: 278 LSAHRSWVEKIVQ 290 ++ W+ Q Sbjct: 441 VAEFLDWIHDTAQ 453 >gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] Length = 638 Score = 182 bits (462), Expect = 3e-46 Identities = 100/254 (39%), Positives = 145/254 (57%), Gaps = 13/254 (5%) Query: 49 RVVGGEDSTDSEWPWIVSIQKNGT---HHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVL 105 R+VGG +S+ EWPW VS+Q T H C GSL+ +WV+TAAHCF D L ++ + Sbjct: 390 RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCF-DGLPLQDVWRIY 448 Query: 106 LGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDA 165 G L + + + + H Y EG DIAL++L+ + ++E PICLP Sbjct: 449 SGILNLSDITKDTPFSQIKEIIIHQNYKVSEGN-HDIALIKLQAPLNYTEFQKPICLPSK 507 Query: 166 SIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDM 225 T+CW++GWG ++ + + LQK+ +P++ +E C Y IT+ M Sbjct: 508 GDTSTIYTNCWVTGWGFSKEKGEIQN--ILQKVNIPLVTNEECQKRYQ----DYKITQRM 561 Query: 226 LCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWV 285 +CAGY EG +DAC GDSGGPL+C+ +G W L GI SWGEGCA R +PGVY ++ + W+ Sbjct: 562 VCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWI 621 Query: 286 EKIVQGVQLRGRAQ 299 + Q G+AQ Sbjct: 622 LEKTQSSD--GKAQ 633 >gi|4503627 coagulation factor XI precursor [Homo sapiens] Length = 625 Score = 182 bits (461), Expect = 4e-46 Identities = 98/249 (39%), Positives = 137/249 (55%), Gaps = 15/249 (6%) Query: 49 RVVGGEDSTDSEWPWIVSIQKNGT---HHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVL 105 R+VGG S EWPW V++ H C GS++ ++W++TAAHCF + P + V Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFY-GVESPKILRVY 445 Query: 106 LGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDA 165 G + GV + H Y E DIAL++LE ++ +++ PICLP Sbjct: 446 SGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGY-DIALLKLETTVNYTDSQRPICLPSK 504 Query: 166 SIHLPPNTHCWISGWG--SIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITE 223 T CW++GWG ++D + TLQK K+P++ +E C Y RG IT Sbjct: 505 GDRNVIYTDCWVTGWGYRKLRDKIQ----NTLQKAKIPLVTNEECQKRY-RGH---KITH 556 Query: 224 DMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRS 283 M+CAGY EG +DAC GDSGGPL C+ + W L GI SWGEGCA+R RPGVY ++ + Sbjct: 557 KMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVD 616 Query: 284 WVEKIVQGV 292 W+ + Q V Sbjct: 617 WILEKTQAV 625 >gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sapiens] Length = 454 Score = 181 bits (460), Expect = 6e-46 Identities = 101/250 (40%), Positives = 141/250 (56%), Gaps = 11/250 (4%) Query: 40 ACGKPQQLN-RVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNK 98 ACG + + R+VGG S S+WPW S+Q G H C GS++T W+ITAAHC D L Sbjct: 206 ACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD-LYL 264 Query: 99 PYLFSVLLGAWQL-GNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERV 157 P +++ +G L NP + + H Y K DIAL++L + F+E + Sbjct: 265 PKSWTIQVGLVSLLDNPAPSHLVEKIVY---HSKYKPKRLG-NDIALMKLAGPLTFNEMI 320 Query: 158 LPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAG 217 P+CLP++ + P CW SGWG+ +DG P L VP+I +++C+H R Sbjct: 321 QPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASP-VLNHAAVPLISNKICNH---RDVY 376 Query: 218 QGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYIS 277 G I+ MLCAGYL G D+C GDSGGPL+CQ W L G S+G GCAE N+PGVY Sbjct: 377 GGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTR 436 Query: 278 LSAHRSWVEK 287 +++ W+ + Sbjct: 437 VTSFLDWIHE 446 >gi|34098976 marapsin 2 [Homo sapiens] Length = 326 Score = 180 bits (457), Expect = 1e-45 Identities = 103/287 (35%), Positives = 150/287 (52%), Gaps = 20/287 (6%) Query: 10 LGGGCLGTFTSLLLLASTAILNAARIPVPP-----------ACGKPQQLNRVVGGEDSTD 58 LG LG LL++A + AA + P ACG+P +++GG + + Sbjct: 11 LGPSALGLLLLLLVVAPPRV--AALVHRQPENQGISLTGSVACGRPSMEGKILGGVPAPE 68 Query: 59 SEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRS 118 +WPW VS+ G H C GS+L WV++AAHCF + N ++ + +G L G+ + Sbjct: 69 RKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIK-IYDMYVGLVNLRVAGNHT 127 Query: 119 QKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWIS 178 Q V V HP Y D+ALV+L+ I FSE VLP+CL ++L + +CW + Sbjct: 128 QWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVNLT-SANCWAT 186 Query: 179 GWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDAC 238 GWG + LQ++++P+I C LY I DMLCAG + + C Sbjct: 187 GWGLVSKQGETS--DELQEMQLPLILEPWCHLLYGH---MSYIMPDMLCAGDILNAKTVC 241 Query: 239 LGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWV 285 GDSGGPL+C+ + +WL GI+SWG GC+ PGVY S+S W+ Sbjct: 242 EGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWI 288 >gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sapiens] Length = 432 Score = 178 bits (452), Expect = 5e-45 Identities = 106/251 (42%), Positives = 146/251 (58%), Gaps = 15/251 (5%) Query: 40 ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99 ACGK + RVVGGE+++ WPW VSIQ + H C GS+L WV+TAAHCF+ + + Sbjct: 190 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTD-V 248 Query: 100 YLFSVLLGAWQLGN-PGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVL 158 + + V G+ +LG+ P K+ + +E +P+Y DIAL++L+ + FS V Sbjct: 249 FNWKVRAGSDKLGSFPSLAVAKIII--IEFNPMYPKDN----DIALMKLQFPLTFSGTVR 302 Query: 159 PICLPDASIHLPPNTHCWISGWG-SIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAG 217 PICLP L P T WI GWG + Q+G + L + V +IDS C+ A Sbjct: 303 PICLPFFDEELTPATPLWIIGWGFTKQNGGKM--SDILLQASVQVIDSTRCNA---DDAY 357 Query: 218 QGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYIS 277 QG +TE M+CAG EG D C GDSGGPLM Q D W + GI+SWG GC + PGVY Sbjct: 358 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTK 416 Query: 278 LSAHRSWVEKI 288 +SA+ +W+ + Sbjct: 417 VSAYLNWIYNV 427 >gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sapiens] Length = 437 Score = 178 bits (452), Expect = 5e-45 Identities = 106/251 (42%), Positives = 146/251 (58%), Gaps = 15/251 (5%) Query: 40 ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99 ACGK + RVVGGE+++ WPW VSIQ + H C GS+L WV+TAAHCF+ + + Sbjct: 195 ACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTD-V 253 Query: 100 YLFSVLLGAWQLGN-PGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVL 158 + + V G+ +LG+ P K+ + +E +P+Y DIAL++L+ + FS V Sbjct: 254 FNWKVRAGSDKLGSFPSLAVAKIII--IEFNPMYPKDN----DIALMKLQFPLTFSGTVR 307 Query: 159 PICLPDASIHLPPNTHCWISGWG-SIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAG 217 PICLP L P T WI GWG + Q+G + L + V +IDS C+ A Sbjct: 308 PICLPFFDEELTPATPLWIIGWGFTKQNGGKM--SDILLQASVQVIDSTRCNA---DDAY 362 Query: 218 QGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYIS 277 QG +TE M+CAG EG D C GDSGGPLM Q D W + GI+SWG GC + PGVY Sbjct: 363 QGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGPSTPGVYTK 421 Query: 278 LSAHRSWVEKI 288 +SA+ +W+ + Sbjct: 422 VSAYLNWIYNV 432 >gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sapiens] Length = 529 Score = 176 bits (447), Expect = 2e-44 Identities = 93/253 (36%), Positives = 139/253 (54%), Gaps = 18/253 (7%) Query: 40 ACG---KPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNL 96 ACG + +R+VGGE + WPW VS+ H C GS++T W++TAAHC + L Sbjct: 280 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 339 Query: 97 NKPYLFSVLLG----AWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQ 152 N P+ ++ G ++ G + +KV HP Y K DIAL++L++ + Sbjct: 340 NNPWHWTAFAGILRQSFMFYGAGYQVEKV-----ISHPNYDSKTKN-NDIALMKLQKPLT 393 Query: 153 FSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLY 212 F++ V P+CLP+ + L P CWISGWG+ ++ + L KV +I+++ C+ Y Sbjct: 394 FNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTS--EVLNAAKVLLIETQRCNSRY 451 Query: 213 WRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRP 272 IT M+CAG+L+G D+C GDSGGPL+ + W L G SWG GCA+ RP Sbjct: 452 ---VYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRP 508 Query: 273 GVYISLSAHRSWV 285 GVY ++ W+ Sbjct: 509 GVYGNVMVFTDWI 521 >gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sapiens] Length = 492 Score = 176 bits (447), Expect = 2e-44 Identities = 93/253 (36%), Positives = 139/253 (54%), Gaps = 18/253 (7%) Query: 40 ACG---KPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNL 96 ACG + +R+VGGE + WPW VS+ H C GS++T W++TAAHC + L Sbjct: 243 ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPL 302 Query: 97 NKPYLFSVLLG----AWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQ 152 N P+ ++ G ++ G + +KV HP Y K DIAL++L++ + Sbjct: 303 NNPWHWTAFAGILRQSFMFYGAGYQVEKV-----ISHPNYDSKTKN-NDIALMKLQKPLT 356 Query: 153 FSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLY 212 F++ V P+CLP+ + L P CWISGWG+ ++ + L KV +I+++ C+ Y Sbjct: 357 FNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTS--EVLNAAKVLLIETQRCNSRY 414 Query: 213 WRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRP 272 IT M+CAG+L+G D+C GDSGGPL+ + W L G SWG GCA+ RP Sbjct: 415 ---VYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRP 471 Query: 273 GVYISLSAHRSWV 285 GVY ++ W+ Sbjct: 472 GVYGNVMVFTDWI 484 >gi|21614533 testisin isoform 3 [Homo sapiens] Length = 300 Score = 176 bits (445), Expect = 3e-44 Identities = 99/289 (34%), Positives = 152/289 (52%), Gaps = 31/289 (10%) Query: 13 GCLGTFTSLLLLASTAIL---NAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQK 69 G G LLLA + + P+ CG+ +R+VGGED+ WPW S++ Sbjct: 2 GARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRL 61 Query: 70 NGTHHCAGSLLTSRWVITAAHCFK--DNLNKPYLFSVLLGA-------WQLGNPGSRSQK 120 +H C SLL+ RW +TAAHCF+ +L+ P + V G W L +R Sbjct: 62 WDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTR-YF 120 Query: 121 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW 180 V ++ P + + DIALV+L + +++ + PICL ++ T CW++GW Sbjct: 121 VSNIYLSPR----YLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGW 176 Query: 181 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLG 240 G I++ LP P TLQ+++V II++ +C+HL+ + + + I DM G Sbjct: 177 GYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDM--------------G 222 Query: 241 DSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 289 DSGGPL C +G W G++SWG GC NRPGVY ++S H W++K++ Sbjct: 223 DSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM 271 >gi|194018492 transmembrane protease, serine 11F [Homo sapiens] Length = 438 Score = 173 bits (438), Expect = 2e-43 Identities = 100/257 (38%), Positives = 152/257 (59%), Gaps = 15/257 (5%) Query: 30 LNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGT-HHCAGSLLTSRWVITA 88 + ++ +P+P A Q++ V G E + + EWPW S+Q G+ H C SL+++ W++TA Sbjct: 190 MTSSNMPLP-ASSSTQRI--VQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTA 246 Query: 89 AHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLE 148 AHCF N + P + GA + P + K V + H Y +E DIALV+L Sbjct: 247 AHCFWKNKD-PTQWIATFGA-TITPP---AVKRNVRKIILHENYH-RETNENDIALVQLS 300 Query: 149 RSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVC 208 ++FS V +CLPD+SI LPP T +++G+GSI D P+ + TL++ +V I ++VC Sbjct: 301 TGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQN--TLRQARVETISTDVC 358 Query: 209 SHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAE 268 + + G IT MLCAG++EG+ DAC GDSGGPL+ W + GI+SWG+ CA Sbjct: 359 NR---KDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCAL 415 Query: 269 RNRPGVYISLSAHRSWV 285 +PGVY ++ +R W+ Sbjct: 416 PKKPGVYTRVTKYRDWI 432 >gi|187761337 transmembrane protease, serine 11B [Homo sapiens] Length = 416 Score = 172 bits (435), Expect = 5e-43 Identities = 94/242 (38%), Positives = 146/242 (60%), Gaps = 18/242 (7%) Query: 48 NRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCF-KDNLNKPYL--FSV 104 N++V G+ S + WPW S+Q G H+C SL++SRW+++AAHCF K N +K + F + Sbjct: 183 NKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGI 242 Query: 105 LLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPD 164 ++ N ++K V + H YS G DIALV+L + F+E + ICLP+ Sbjct: 243 VV------NKPYMTRK--VQNIIFHENYS-SPGLHDDIALVQLAEEVSFTEYIRKICLPE 293 Query: 165 ASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITED 224 A + L N + ++GWG++ + P LQ+ + IID+++C+ Y A G +T+ Sbjct: 294 AKMKLSENDNVVVTGWGTLY--MNGSFPVILQEDFLKIIDNKICNASY---AYSGFVTDT 348 Query: 225 MLCAGYLEGERDACLGDSGGPLMC-QVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRS 283 MLCAG++ GE DAC DSGGPL W L GI+SWG+GC ++N+PGVY ++++R+ Sbjct: 349 MLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRN 408 Query: 284 WV 285 W+ Sbjct: 409 WI 410 >gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens] Length = 410 Score = 171 bits (434), Expect = 6e-43 Identities = 89/252 (35%), Positives = 132/252 (52%), Gaps = 19/252 (7%) Query: 40 ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99 ACG +++R++GG + + +WPW VS+Q + HHC GSL+ RWV+TAAHC Sbjct: 155 ACG--HRVSRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWE 212 Query: 100 YLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACA----DIALVRLERSIQFSE 155 G W L G Q AW + A DIAL L S+ +S Sbjct: 213 G------GRWLLAGIGRWDQ----AWKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSS 262 Query: 156 RVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRG 215 + P CLP+ + T CW++GWG + + V P P LQ+ ++ I+ E C + Sbjct: 263 HIQPACLPEKLFEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNK 322 Query: 216 --AGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPG 273 + +T +C GY + +DAC GDSGGPL+C+++G W+ GI+SWG GC + PG Sbjct: 323 NISKSKMVTRGTVC-GYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPG 381 Query: 274 VYISLSAHRSWV 285 VY +S ++ W+ Sbjct: 382 VYTEVSFYKKWI 393 >gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo sapiens] Length = 410 Score = 171 bits (434), Expect = 6e-43 Identities = 89/252 (35%), Positives = 132/252 (52%), Gaps = 19/252 (7%) Query: 40 ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99 ACG +++R++GG + + +WPW VS+Q + HHC GSL+ RWV+TAAHC Sbjct: 155 ACG--HRVSRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWE 212 Query: 100 YLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACA----DIALVRLERSIQFSE 155 G W L G Q AW + A DIAL L S+ +S Sbjct: 213 G------GRWLLAGIGRWDQ----AWKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSS 262 Query: 156 RVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRG 215 + P CLP+ + T CW++GWG + + V P P LQ+ ++ I+ E C + Sbjct: 263 HIQPACLPEKLFEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNK 322 Query: 216 --AGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPG 273 + +T +C GY + +DAC GDSGGPL+C+++G W+ GI+SWG GC + PG Sbjct: 323 NISKSKMVTRGTVC-GYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPG 381 Query: 274 VYISLSAHRSWV 285 VY +S ++ W+ Sbjct: 382 VYTEVSFYKKWI 393 >gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo sapiens] Length = 410 Score = 171 bits (434), Expect = 6e-43 Identities = 89/252 (35%), Positives = 132/252 (52%), Gaps = 19/252 (7%) Query: 40 ACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99 ACG +++R++GG + + +WPW VS+Q + HHC GSL+ RWV+TAAHC Sbjct: 155 ACG--HRVSRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWE 212 Query: 100 YLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACA----DIALVRLERSIQFSE 155 G W L G Q AW + A DIAL L S+ +S Sbjct: 213 G------GRWLLAGIGRWDQ----AWKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSS 262 Query: 156 RVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRG 215 + P CLP+ + T CW++GWG + + V P P LQ+ ++ I+ E C + Sbjct: 263 HIQPACLPEKLFEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNK 322 Query: 216 --AGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPG 273 + +T +C GY + +DAC GDSGGPL+C+++G W+ GI+SWG GC + PG Sbjct: 323 NISKSKMVTRGTVC-GYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPG 381 Query: 274 VYISLSAHRSWV 285 VY +S ++ W+ Sbjct: 382 VYTEVSFYKKWI 393 >gi|33695155 hepsin [Homo sapiens] Length = 417 Score = 170 bits (430), Expect = 2e-42 Identities = 103/270 (38%), Positives = 140/270 (51%), Gaps = 20/270 (7%) Query: 41 CGKPQ-QLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKP 99 CG+ + ++R+VGG D++ WPW VS++ +G H C GSLL+ WV+TAAHCF + Sbjct: 153 CGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVL 212 Query: 100 YLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVY-----SWKEGACADIALVRLERSIQFS 154 + V GA +P ++GV V H Y E DIALV L + + Sbjct: 213 SRWRVFAGAVAQASP--HGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270 Query: 155 ERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWR 214 E + P+CLP A L C ++GWG+ Q LQ+ +VPII ++VC+ + Sbjct: 271 EYIQPVCLPAAGQALVDGKICTVTGWGNTQ--YYGQQAGVLQEARVPIISNDVCNGADFY 328 Query: 215 GAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVD----GAWLLAGIISWGEGCAERN 270 G I M CAGY EG DAC GDSGGP +C+ W L GI+SWG GCA Sbjct: 329 G---NQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQ 385 Query: 271 RPGVYISLSAHRSWVEKIVQGVQLRGRAQG 300 +PGVY +S R W I Q ++ A G Sbjct: 386 KPGVYTKVSDFREW---IFQAIKTHSEASG 412 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.137 0.454 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,821,292 Number of Sequences: 37866 Number of extensions: 751670 Number of successful extensions: 2219 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 170 Number of HSP's successfully gapped in prelim test: 13 Number of HSP's that attempted gapping in prelim test: 1549 Number of HSP's gapped (non-prelim): 206 length of query: 317 length of database: 18,247,518 effective HSP length: 102 effective length of query: 215 effective length of database: 14,385,186 effective search space: 3092814990 effective search space used: 3092814990 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.