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Search of human proteins with 115430239
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5
[Homo sapiens]
(678 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [... 1330 0.0
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 1265 0.0
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 672 0.0
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 672 0.0
gi|67782321 spectrin beta isoform a [Homo sapiens] 577 e-165
gi|67782319 spectrin beta isoform b [Homo sapiens] 577 e-165
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 531 e-150
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 269 7e-72
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 203 4e-52
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 203 4e-52
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 185 1e-46
gi|221316624 dystonin isoform 4 [Homo sapiens] 97 5e-20
gi|221316622 dystonin isoform 3 [Homo sapiens] 97 5e-20
gi|221316618 dystonin isoform 2 [Homo sapiens] 97 5e-20
gi|34577047 dystonin isoform 1 [Homo sapiens] 97 5e-20
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 97 5e-20
gi|33188443 microfilament and actin filament cross-linker protei... 84 4e-16
gi|33188445 microfilament and actin filament cross-linker protei... 84 4e-16
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 78 3e-14
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 78 3e-14
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 77 5e-14
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 75 2e-13
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 75 3e-13
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 74 4e-13
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 74 4e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 70 5e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 70 5e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 70 5e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 70 5e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 70 5e-12
>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5
[Homo sapiens]
Length = 678
Score = 1330 bits (3441), Expect = 0.0
Identities = 678/678 (100%), Positives = 678/678 (100%)
Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK
Sbjct: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT
Sbjct: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL
Sbjct: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI
Sbjct: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE
Sbjct: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC
Sbjct: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA
Sbjct: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
Query: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480
EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT
Sbjct: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480
Query: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540
MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP
Sbjct: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540
Query: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600
EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW
Sbjct: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600
Query: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGLPASP 660
KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGLPASP
Sbjct: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGLPASP 660
Query: 661 WWPTPATPSPLTAPFSME 678
WWPTPATPSPLTAPFSME
Sbjct: 661 WWPTPATPSPLTAPFSME 678
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 1265 bits (3273), Expect = 0.0
Identities = 650/653 (99%), Positives = 651/653 (99%)
Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK
Sbjct: 1325 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 1384
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT
Sbjct: 1385 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 1444
Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL
Sbjct: 1445 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 1504
Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI
Sbjct: 1505 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 1564
Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE
Sbjct: 1565 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 1624
Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC
Sbjct: 1625 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 1684
Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA
Sbjct: 1685 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 1744
Query: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480
EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT
Sbjct: 1745 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 1804
Query: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540
MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP
Sbjct: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
Query: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600
EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW
Sbjct: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 1924
Query: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653
KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPR SS+
Sbjct: 1925 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSV 1977
Score = 149 bits (376), Expect = 8e-36
Identities = 164/667 (24%), Positives = 274/667 (41%), Gaps = 48/667 (7%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+H+A A++A +E ++ + Q L E V + + + WA L A+
Sbjct: 470 KHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRT 529
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+L + ++ Q + + M++QL + G L + L+K +E +
Sbjct: 530 RLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSE 589
Query: 141 EVGELQAQTAALP----LEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
V L A +P +++ R N V L L E RR L AS+ L +
Sbjct: 590 RVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWAL 649
Query: 197 AHDLDDELAWVQERLPLAMQTERGNG----------------------LQAVQQHIKKNQ 234
+L++ +W +++ L ++ G G L A + ++
Sbjct: 650 LQELEEAESWARDKERL-LEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGEL 708
Query: 235 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR-GL-EQLQSA---WAGLREAAERR 289
G RR + R E L AG P A+ V GL E+ SA W L EAA RR
Sbjct: 709 GGRRALLQQALRCGEELVAAGGAVG---PGADTVHLVGLAERAASARRRWQRLEEAAARR 765
Query: 290 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349
++ L A + Q+ D+ + WL + L + D G DE S+ +L ++H L VE +
Sbjct: 766 ERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAH 825
Query: 350 EESIAQLSRQCRAL--LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQ 407
++ L RQ L P + R + ++L+ + E+ RR L +Y+
Sbjct: 826 RGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYR 885
Query: 408 LSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467
+ +V E WI EKE S + + V V+Q +F E R+ VN V
Sbjct: 886 MFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSL-MGRVLDVNHTV 944
Query: 468 DELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527
EL+E GH ++ + +D LN W ++EL+ R + ++A + + E++ Q+
Sbjct: 945 QELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVR 1004
Query: 528 EKRRRLPRLTTPPEPRPSA-SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586
EKRR + E P A ++Q L E LQ L + L E AA L + + A
Sbjct: 1005 EKRRAV-------ESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQ-A 1056
Query: 587 EAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADK 646
+ +E+ W L SA + V++ RF + L W+ G ++
Sbjct: 1057 ARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEG 1116
Query: 647 PRCPSSL 653
P P+SL
Sbjct: 1117 P-LPNSL 1122
Score = 84.0 bits (206), Expect = 4e-16
Identities = 96/395 (24%), Positives = 163/395 (41%), Gaps = 52/395 (13%)
Query: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229
G+R+ ++L+ + E +++ +EL A +L LAW+ + L + N L VQQ
Sbjct: 294 GKRIGKVLDQVLEVGKIIERYEEL---AAEL---LAWIHRTVGLISNQKFANSLSGVQQQ 347
Query: 230 IKKNQG---LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR--------GLEQLQSA 278
++ L + ++ EVL L S++S RR G+ + A
Sbjct: 348 LQAFTAYCTLEKPVKFQEKGNLEVL-----LFSIQSKLRACNRRLFVPREGCGIWDIDKA 402
Query: 279 WAGL------REAAERRQQVLDAAFQVEQYYFD--VAEVEAWLGEQELLMMSEDKGKDEQ 330
W L REAA R + + ++ FD VA E+WL E + L+ ++ G +
Sbjct: 403 WGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELP 462
Query: 331 STLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE 390
+ +KKH +E + YEE + ++ +AL G+ D +++ ++ V R + L
Sbjct: 463 AVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTG 522
Query: 391 LGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS 450
L RR LEQ L ++ +++ + W+ E + S E GQ L +K
Sbjct: 523 LVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEG 582
Query: 451 ETGMAGRERLAAVN------------QMVDELIECGHTAAATMAEWKDGLNEAWAELLEL 498
+ A ER+ A+N Q D + C + ++ AEL E
Sbjct: 583 DIA-AQSERVEALNAAALRFSQLQGYQPCDPQVICNRV---------NHVHGCLAELQEQ 632
Query: 499 MGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 533
R L ASR L + E + +K R L
Sbjct: 633 AARRRAELEASRSLWALLQELEEAESWARDKERLL 667
Score = 78.6 bits (192), Expect = 2e-14
Identities = 67/329 (20%), Positives = 143/329 (43%), Gaps = 3/329 (0%)
Query: 33 KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLV 92
+E L + + +L++ AA++ + + + WAEL +A+ L + + +
Sbjct: 1781 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 1840
Query: 93 QSFAELDKKLLHMESQLQDVD-PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 151
EL ++ +L + P + +S + L++ E ++ +V +LQ A
Sbjct: 1841 SDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 1900
Query: 152 LPLEPASK--ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQE 209
L A + E + R+ V + LL ++ R + ++ + + + D L+W+
Sbjct: 1901 LRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDG 1960
Query: 210 RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR 269
++ + +V+ + +QGL+ E++A P L E +L +S A+ ++
Sbjct: 1961 IASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ 2020
Query: 270 RGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE 329
L++L + + E +R + L +V Q+ + +AWL QE L+ S + G
Sbjct: 2021 AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSV 2080
Query: 330 QSTLQLLKKHLQLEQGVENYEESIAQLSR 358
QL+++H + +EE + L R
Sbjct: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRR 2109
Score = 75.1 bits (183), Expect = 2e-13
Identities = 90/476 (18%), Positives = 201/476 (42%), Gaps = 17/476 (3%)
Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
+LM + +D + +H + +E + ++ R+ + L++ + + ++
Sbjct: 1642 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRR 1701
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
++ + + L+ + + L + QL + +EL+ + E + G D
Sbjct: 1702 QSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEH 1761
Query: 121 VNSQLKKLQSMESQVEEWYRE--VGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178
V+ +K S+ RE Q + + + E ++ + E LLE
Sbjct: 1762 VSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLE 1821
Query: 179 PLQERRRLLLASKELHQV---AHDLDDELAWVQERLP-LAMQTERGNGLQAVQQHIKKNQ 234
+ R +LL AS+ELH+ A +L ++ + RLP L E ++Q+ ++
Sbjct: 1822 LMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR--- 1878
Query: 235 GLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVL 293
++Q ++ ++ E A L ++ + E AEA+ +++ W L A E + +
Sbjct: 1879 AFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHV 1938
Query: 294 DAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI 353
+ +++ V ++ +W+ + + DK +D S L+ H L+ +E +
Sbjct: 1939 SSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPEL 1998
Query: 354 AQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE---RRVALEQQYWLYQLSR 410
R+LL +++I Q+Q+D+L +E+ E+ L+Q ++Q ++
Sbjct: 1999 TTCQELGRSLLLNKSAMADEI---QAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQ 2055
Query: 411 QVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQM 466
+ + W+ +E + S ELG + V L + F + A ER +++ ++
Sbjct: 2056 EAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF-RKAAAAWEERFSSLRRL 2110
Score = 72.8 bits (177), Expect = 1e-12
Identities = 120/631 (19%), Positives = 261/631 (41%), Gaps = 31/631 (4%)
Query: 42 EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF-AELDK 100
E L + P AA + + E+ W L S QA + A + + + A LD
Sbjct: 1044 EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDW 1103
Query: 101 KLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK 159
+ E+ P L ++ L + +++ +V++ + + A + AL ++
Sbjct: 1104 LVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAE 1163
Query: 160 ELVGERQNAVGERLVRL------LEPLQERRRLLLASKELHQV-AHDLDDELAWVQERLP 212
G A+ E L L L L E RR L ++Q+ DL L ++ +
Sbjct: 1164 LGPGL---ALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEM 1220
Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL---ASLRSPEA-EAV 268
E +++V++ +K+++ ++ +++ ++ A L ++ +A EAV
Sbjct: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAV 1280
Query: 269 RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKD 328
R LE+ Q + A++ Q L +++ + D E++ W+ E+ +LM + +D
Sbjct: 1281 TRLLEKNQEN----QLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEK-MLMARDGTRED 1335
Query: 329 EQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVAL 388
+ +H + +E + ++ R+ + L++ + + ++ ++ + + L
Sbjct: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAEL 1395
Query: 389 KELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEF 448
+ + + L + QL + +EL+ + E + G D V+ +K
Sbjct: 1396 ESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
Query: 449 ASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAA 508
S+ RE Q + + + E ++ + E LLE + R +LL A
Sbjct: 1456 ESQVEEWYRE--VGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLA 1513
Query: 509 SRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQLLVS 565
S+ELH+ A +L ++ + RLP L E ++Q+ ++ ++Q
Sbjct: 1514 SKELHQV---AHDLDDELAWVQERLP-LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 1569
Query: 566 QVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHS 625
++ ++ E A L ++ + E AEA+ +++ W L A E + + + +++
Sbjct: 1570 RLEEVLERAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 1628
Query: 626 QVRDLLSWMDGIASQIGAADKPRCPSSLLGL 656
V ++ +W+ + + DK + S L L
Sbjct: 1629 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQL 1659
Score = 69.3 bits (168), Expect = 1e-11
Identities = 112/605 (18%), Positives = 228/605 (37%), Gaps = 32/605 (5%)
Query: 44 QQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL 103
Q+L++ + VR + W + + + ++ + V AE+ ++
Sbjct: 945 QELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVR 1004
Query: 104 HMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVG 163
++ G + +L L++ +E R+ L+ PA +
Sbjct: 1005 EKRRAVESAPRAG--GALQWRLSGLEAALQALEP--RQAALLEEAALLAERFPAQAARLH 1060
Query: 164 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERG--N 221
+ +G L Q + A+ L + HDLD L W+ A +E N
Sbjct: 1061 QGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPN 1120
Query: 222 GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE---AVRRGLEQLQSA 278
L+ + ++ L+ E+ ++ + AL + E A+ L L+
Sbjct: 1121 SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELG 1180
Query: 279 WAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKK 338
W L E R++ L A + + D+ + L QE+ + + +S + LK+
Sbjct: 1181 WHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQ 1240
Query: 339 HLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVA 398
H +E ++ + + LL G+ EQ Q V RL L + +
Sbjct: 1241 HRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQ---AQEAVTRL------LEKNQENQ 1291
Query: 399 LEQQYWLYQLSRQVS---------ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFA 449
L Q W+ +L Q+ EL+ WI EK ++A +D + + F
Sbjct: 1292 LRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMA-RDGTREDNHKLHKRWLRHQAFM 1350
Query: 450 SETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAAS 509
+E +E L + + +L++ AA++ + + + WAEL +A+ L +
Sbjct: 1351 AELAQ-NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEA 1409
Query: 510 RELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQ 569
+ + EL ++ +L + P + +S + L++ E ++ +V +
Sbjct: 1410 SKADQLVQSFAELDKKLLHMESQLQDV-DPGGDLATVNSQLKKLQSMESQVEEWYREVGE 1468
Query: 570 LQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRD 629
LQ A L A + E + R+ V + LL ++ R + ++ + + + D
Sbjct: 1469 LQAQTAALPLEPASK--ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDD 1526
Query: 630 LLSWM 634
L+W+
Sbjct: 1527 ELAWV 1531
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 672 bits (1734), Expect = 0.0
Identities = 346/654 (52%), Positives = 465/654 (71%), Gaps = 3/654 (0%)
Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
ML A+D + ++ LH +WL+HQAFMAELA NKEWL+KIE+EG QL+ EKPE A V++K
Sbjct: 1282 MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEK 1341
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
L + + W LESTTQ KA++LF+A+KA+ QS A+LDK L +ESQ+Q D G DL +
Sbjct: 1342 LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTS 1401
Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
VN LKK Q +E+Q+E +E+ ELQ+Q AL E S + V ++ V + + LLEPL
Sbjct: 1402 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1461
Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
ER+ LLASKE+HQ D++DE+ WV ER+PLA T+ G+ LQ VQ IKKNQ L++EI
Sbjct: 1462 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEI 1521
Query: 241 QAHGPRLEEVLERA-GALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV 299
Q H PR++++ ER+ + S AEA+R+ L L+ W L E E+R + L+ A +
Sbjct: 1522 QGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRA 1581
Query: 300 EQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ 359
+QYYFD AE EAW+ EQEL MMSE+K KDEQS + +LKKH LEQ VE+Y E++ QLS+
Sbjct: 1582 QQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKT 1641
Query: 360 CRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419
RAL+ HP+SE+IS RQS+VD+LY LK+L EERR L++++ L+QL+R+V +LE WI
Sbjct: 1642 SRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWI 1701
Query: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479
AE+EVVAGS ELGQD+EHV++LQE+F EFA +TG G+ER+ VN + DELI GH+ AA
Sbjct: 1702 AEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAA 1761
Query: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539
T+AEWKDGLNEAWA+LLEL+ TR Q+LAAS ELHKF+ DA+E+ G+I++K ++LP
Sbjct: 1762 TIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE--EL 1819
Query: 540 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599
+ + ++QR FEHD+Q L +QVRQLQE AA+L+ YAG+ A+ I RE EVL+
Sbjct: 1820 GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEA 1879
Query: 600 WKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653
WK LL ACE R+ + T D RF S VRDL+ WM+ + QI A +KPR SS+
Sbjct: 1880 WKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1933
Score = 191 bits (485), Expect = 2e-48
Identities = 138/651 (21%), Positives = 285/651 (43%), Gaps = 8/651 (1%)
Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
L+++D D + +H+A ++A +E ++ + ++L E + +
Sbjct: 431 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 490
Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
+ + W L +A+ ++L ++ Q + + M+ + D G L V
Sbjct: 491 DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGV 550
Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLE-----PASKELVGERQNAVGERLVRL 176
L+K +E+ + V + A + P +++ +R + L
Sbjct: 551 EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 610
Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236
+ ERR L S+ L + ++ +E W++E+ + + G L +V + + K++
Sbjct: 611 CQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAF 670
Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296
E+ E+ ++ + + +E +R + ++ WA L + + R++ L+ A
Sbjct: 671 EDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 730
Query: 297 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 356
+ Q+ D +++AW+ + ++ S D G DE ST L+KKH + + + NY ++ L
Sbjct: 731 SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTL 790
Query: 357 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 416
Q A L H +S + R S ++ Y + EL R+ AL+ LY++ + E
Sbjct: 791 HEQASA-LPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACE 849
Query: 417 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 476
WI EKE + ++ + E + V+Q +F E R+A VNQ+ +L+ GH
Sbjct: 850 LWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQA-SRVAVVNQIARQLMHSGHP 908
Query: 477 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 536
+ + +D LN W++ EL+ + L ++ + + + E + I EK + +
Sbjct: 909 SEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIEST 968
Query: 537 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 596
++QR L E DL + +++ LQ+ A +L + + + A+AI SR E+
Sbjct: 969 QDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEI 1027
Query: 597 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647
W+E+ + ++ + + +F + D SW+ + I + D P
Sbjct: 1028 SDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMP 1078
Score = 133 bits (335), Expect = 5e-31
Identities = 135/638 (21%), Positives = 275/638 (43%), Gaps = 28/638 (4%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+H+ E+A + L+ + + L QE E + VR +L I + + E+ T+ + +
Sbjct: 772 KHKDVAEEIANYRPTLDTLHEQASALPQEHAE-SPDVRGRLSGIEERYKEVAELTRLRKQ 830
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
L + L + F+E D L ++ + Q ++ + +L+ L+ ++ + E
Sbjct: 831 ALQDTLA---LYKMFSEADACELWIDEKEQWLNN----MQIPEKLEDLEVIQHRFESLEP 883
Query: 141 EVGELQAQTAALPL---------EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASK 191
E+ ++ A + P+ KE+ + Q+ + R + E + ++ LL++
Sbjct: 884 EMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQ-QDKLNTRWSQFRELVDRKKDALLSAL 942
Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTER-GNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
+ + ++ +W++E+ + T+ GN L V +K G+ R++ A +L ++
Sbjct: 943 SIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL 1002
Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVE 310
+ A L S +A+A+ L ++ W ++ + R+ L A +++Q+ D+ + +
Sbjct: 1003 QKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ 1062
Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
+WL + + SED +LL +H ++ ++NYEE Q R ++ G D
Sbjct: 1063 SWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDY-QKMRDMGEMVTQGQTD 1121
Query: 371 SEQISRRQ--SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 428
++ + RQ +D + L ++ E R+ L Q + Q R + E ++ +E V
Sbjct: 1122 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1181
Query: 429 PELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGL 488
E+ E +K +F + T A E++ AV + L+ G+ + + E D +
Sbjct: 1182 TEMPTTLEGAEAAIKKQEDFMT-TMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSI 1240
Query: 489 NEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 548
++ + E L +R+L KF D +EL I EK L + + S
Sbjct: 1241 DDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEK--MLTAQDMSYDEARNLHS 1298
Query: 549 MQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL-QGWKELLSAC 607
+AF +L + ++++ QL + EA+ + L + W+ L S
Sbjct: 1299 KWLKHQAFMAELASNKEWLDKIEKEGMQL--ISEKPETEAVVKEKLTGLHKMWEVLESTT 1356
Query: 608 EDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
+ + A F DL W+ G+ SQI + D
Sbjct: 1357 QTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDD 1394
Score = 100 bits (249), Expect = 4e-21
Identities = 119/500 (23%), Positives = 212/500 (42%), Gaps = 39/500 (7%)
Query: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229
G+R+ ++L+ E +++ ++ +A DL L W+++ + + + N L VQQ
Sbjct: 274 GKRIGKVLDNAIETEKMI---EKYESLASDL---LEWIEQTIIILNNRKFANSLVGVQQQ 327
Query: 230 IKKNQGLRREIQ----AHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGLR 283
++ R + LE +L + + + R G + + AW L
Sbjct: 328 LQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLE 387
Query: 284 EAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQL 335
+A R+ L ++EQ FD A E WL E + L+ ++ G D +
Sbjct: 388 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 447
Query: 336 LKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEER 395
KKH +E + YEE + + R L + D ++I+ R+ V RL+ L EL R
Sbjct: 448 TKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRAR 507
Query: 396 RVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMA 455
R LE L ++ +++ + W+ E +V+ S + G+ V L +K + ++ G+
Sbjct: 508 RQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQ 567
Query: 456 GRERLAAVNQMVDELIECGH----TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511
ER+ VN + G + + + + EL +L R L SR
Sbjct: 568 A-ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRR 626
Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVR 568
L KFF + E +G I EK ++ + + +S+ R L RAFE ++
Sbjct: 627 LWKFFWEMAEEEGWIREKE----KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFE 682
Query: 569 Q-LQEGAAQLRTVYAGEHAEAIASREQEVLQGWKEL--LSACEDARLHVSSTADALRFHS 625
Q ++EG + + G +E I R + + W L LSA RL +S +F +
Sbjct: 683 QAIKEGEDMIAEEHFG--SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH--QFQA 738
Query: 626 QVRDLLSWMDGIASQIGAAD 645
D+ +WM I + ++D
Sbjct: 739 DADDIDAWMLDILKIVSSSD 758
Score = 95.9 bits (237), Expect = 1e-19
Identities = 93/464 (20%), Positives = 200/464 (43%), Gaps = 22/464 (4%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+HQ + E + ++ + + L+ + + + + ++ + +A L+ + +
Sbjct: 1620 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRG 1679
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+L E + QL + +L++ + E + G D V ++ + E+ R
Sbjct: 1680 KLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTM-------LQERFREFAR 1732
Query: 141 EVGELQAQTAALPLEPASKELVG----------ERQNAVGERLVRLLEPLQERRRLLLAS 190
+ G + Q + + EL+ E ++ + E LLE + R ++L AS
Sbjct: 1733 DTGNI-GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAAS 1791
Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
ELH+ HD + +Q++ + E G V+ + + +IQA G ++ ++
Sbjct: 1792 YELHKFYHDAKEIFGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQL 1850
Query: 251 LERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
E A L A+ +A+ +++ ++ AW L +A E R+ L +++ V ++
Sbjct: 1851 QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDL 1910
Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
W+ + + +++K +D S L+ H ++ ++ +S ++LL H
Sbjct: 1911 MLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHY 1970
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
SE+I + Q+ + + E+R L ++Q SR S E W+ +E S
Sbjct: 1971 ASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSR 2030
Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD-ELIE 472
E+GQ + V L ++ F ++ ER +A+ ++ EL+E
Sbjct: 2031 EIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLE 2073
Score = 85.5 bits (210), Expect = 1e-16
Identities = 79/385 (20%), Positives = 162/385 (42%), Gaps = 10/385 (2%)
Query: 33 KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLV 92
+E ++ + +L+ AA++ + + + WA+L + + L + + +
Sbjct: 1739 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFY 1798
Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152
E+ ++ +L + + G D TV + + + E ++ +V +LQ A L
Sbjct: 1799 HDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL 1857
Query: 153 PLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQER 210
A + + +R+N V E LL+ + RR L+ + + + + D + W+++
Sbjct: 1858 QAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDV 1917
Query: 211 LPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR 270
+ E+ + +V+ + +QG++ EI A +E +L + + +E ++
Sbjct: 1918 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1977
Query: 271 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQ 330
L QL + + E R + L +V Q+ D + EAWL QE + S + G+
Sbjct: 1978 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD 2037
Query: 331 STLQLLKKHLQLEQGVENYEESIAQLSR-QCRALLEMGHPDSEQISRRQSQVDRLYVALK 389
+L+K+H E+ ++E + L R LLE+ E+ +R+ +
Sbjct: 2038 EVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2097
Query: 390 ELGEERRVALEQQYWLYQLSRQVSE 414
E E QQ W QVS+
Sbjct: 2098 EEAE------SQQQWDTSKGEQVSQ 2116
Score = 30.0 bits (66), Expect = 7.3
Identities = 48/291 (16%), Positives = 107/291 (36%), Gaps = 20/291 (6%)
Query: 364 LEMGHPDSEQISRRQ-------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 416
+ + HPD + I S++ L V K +G+ A+E + + + S+L
Sbjct: 243 ISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL 302
Query: 417 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS---ETGMAGRERLAAVNQMVDELIEC 473
WI + ++ + + V + F+ + + + L + + +
Sbjct: 303 EWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRA 362
Query: 474 GHTAAATMAEWK--DGLNEAW-----AELLELMGTRAQLLAASR--ELHKFFSDARELQG 524
+ E K +N+AW AE + R +L+ + +L + F ++
Sbjct: 363 NNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRE 422
Query: 525 QIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGE 584
+ +RL P+ + + A E D+ +V+ + A +L +
Sbjct: 423 TWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHD 482
Query: 585 HAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635
+ I +R+ V++ W+ LL R + + ++ ++ WMD
Sbjct: 483 -IKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMD 532
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 672 bits (1734), Expect = 0.0
Identities = 346/654 (52%), Positives = 465/654 (71%), Gaps = 3/654 (0%)
Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
ML A+D + ++ LH +WL+HQAFMAELA NKEWL+KIE+EG QL+ EKPE A V++K
Sbjct: 1295 MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEK 1354
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
L + + W LESTTQ KA++LF+A+KA+ QS A+LDK L +ESQ+Q D G DL +
Sbjct: 1355 LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTS 1414
Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
VN LKK Q +E+Q+E +E+ ELQ+Q AL E S + V ++ V + + LLEPL
Sbjct: 1415 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1474
Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
ER+ LLASKE+HQ D++DE+ WV ER+PLA T+ G+ LQ VQ IKKNQ L++EI
Sbjct: 1475 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEI 1534
Query: 241 QAHGPRLEEVLERA-GALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV 299
Q H PR++++ ER+ + S AEA+R+ L L+ W L E E+R + L+ A +
Sbjct: 1535 QGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRA 1594
Query: 300 EQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ 359
+QYYFD AE EAW+ EQEL MMSE+K KDEQS + +LKKH LEQ VE+Y E++ QLS+
Sbjct: 1595 QQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKT 1654
Query: 360 CRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419
RAL+ HP+SE+IS RQS+VD+LY LK+L EERR L++++ L+QL+R+V +LE WI
Sbjct: 1655 SRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWI 1714
Query: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479
AE+EVVAGS ELGQD+EHV++LQE+F EFA +TG G+ER+ VN + DELI GH+ AA
Sbjct: 1715 AEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAA 1774
Query: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539
T+AEWKDGLNEAWA+LLEL+ TR Q+LAAS ELHKF+ DA+E+ G+I++K ++LP
Sbjct: 1775 TIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE--EL 1832
Query: 540 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599
+ + ++QR FEHD+Q L +QVRQLQE AA+L+ YAG+ A+ I RE EVL+
Sbjct: 1833 GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEA 1892
Query: 600 WKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653
WK LL ACE R+ + T D RF S VRDL+ WM+ + QI A +KPR SS+
Sbjct: 1893 WKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1946
Score = 191 bits (485), Expect = 2e-48
Identities = 138/651 (21%), Positives = 285/651 (43%), Gaps = 8/651 (1%)
Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
L+++D D + +H+A ++A +E ++ + ++L E + +
Sbjct: 444 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503
Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
+ + W L +A+ ++L ++ Q + + M+ + D G L V
Sbjct: 504 DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGV 563
Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLE-----PASKELVGERQNAVGERLVRL 176
L+K +E+ + V + A + P +++ +R + L
Sbjct: 564 EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 623
Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236
+ ERR L S+ L + ++ +E W++E+ + + G L +V + + K++
Sbjct: 624 CQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAF 683
Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296
E+ E+ ++ + + +E +R + ++ WA L + + R++ L+ A
Sbjct: 684 EDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 743
Query: 297 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 356
+ Q+ D +++AW+ + ++ S D G DE ST L+KKH + + + NY ++ L
Sbjct: 744 SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTL 803
Query: 357 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 416
Q A L H +S + R S ++ Y + EL R+ AL+ LY++ + E
Sbjct: 804 HEQASA-LPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACE 862
Query: 417 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 476
WI EKE + ++ + E + V+Q +F E R+A VNQ+ +L+ GH
Sbjct: 863 LWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQA-SRVAVVNQIARQLMHSGHP 921
Query: 477 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 536
+ + +D LN W++ EL+ + L ++ + + + E + I EK + +
Sbjct: 922 SEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIEST 981
Query: 537 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 596
++QR L E DL + +++ LQ+ A +L + + + A+AI SR E+
Sbjct: 982 QDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEI 1040
Query: 597 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647
W+E+ + ++ + + +F + D SW+ + I + D P
Sbjct: 1041 SDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMP 1091
Score = 133 bits (335), Expect = 5e-31
Identities = 135/638 (21%), Positives = 275/638 (43%), Gaps = 28/638 (4%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+H+ E+A + L+ + + L QE E + VR +L I + + E+ T+ + +
Sbjct: 785 KHKDVAEEIANYRPTLDTLHEQASALPQEHAE-SPDVRGRLSGIEERYKEVAELTRLRKQ 843
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
L + L + F+E D L ++ + Q ++ + +L+ L+ ++ + E
Sbjct: 844 ALQDTLA---LYKMFSEADACELWIDEKEQWLNN----MQIPEKLEDLEVIQHRFESLEP 896
Query: 141 EVGELQAQTAALPL---------EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASK 191
E+ ++ A + P+ KE+ + Q+ + R + E + ++ LL++
Sbjct: 897 EMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQ-QDKLNTRWSQFRELVDRKKDALLSAL 955
Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTER-GNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
+ + ++ +W++E+ + T+ GN L V +K G+ R++ A +L ++
Sbjct: 956 SIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL 1015
Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVE 310
+ A L S +A+A+ L ++ W ++ + R+ L A +++Q+ D+ + +
Sbjct: 1016 QKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ 1075
Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
+WL + + SED +LL +H ++ ++NYEE Q R ++ G D
Sbjct: 1076 SWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDY-QKMRDMGEMVTQGQTD 1134
Query: 371 SEQISRRQ--SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 428
++ + RQ +D + L ++ E R+ L Q + Q R + E ++ +E V
Sbjct: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194
Query: 429 PELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGL 488
E+ E +K +F + T A E++ AV + L+ G+ + + E D +
Sbjct: 1195 TEMPTTLEGAEAAIKKQEDFMT-TMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSI 1253
Query: 489 NEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 548
++ + E L +R+L KF D +EL I EK L + + S
Sbjct: 1254 DDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEK--MLTAQDMSYDEARNLHS 1311
Query: 549 MQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL-QGWKELLSAC 607
+AF +L + ++++ QL + EA+ + L + W+ L S
Sbjct: 1312 KWLKHQAFMAELASNKEWLDKIEKEGMQL--ISEKPETEAVVKEKLTGLHKMWEVLESTT 1369
Query: 608 EDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
+ + A F DL W+ G+ SQI + D
Sbjct: 1370 QTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDD 1407
Score = 100 bits (249), Expect = 4e-21
Identities = 119/500 (23%), Positives = 212/500 (42%), Gaps = 39/500 (7%)
Query: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229
G+R+ ++L+ E +++ ++ +A DL L W+++ + + + N L VQQ
Sbjct: 287 GKRIGKVLDNAIETEKMI---EKYESLASDL---LEWIEQTIIILNNRKFANSLVGVQQQ 340
Query: 230 IKKNQGLRREIQ----AHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGLR 283
++ R + LE +L + + + R G + + AW L
Sbjct: 341 LQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLE 400
Query: 284 EAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQL 335
+A R+ L ++EQ FD A E WL E + L+ ++ G D +
Sbjct: 401 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 460
Query: 336 LKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEER 395
KKH +E + YEE + + R L + D ++I+ R+ V RL+ L EL R
Sbjct: 461 TKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRAR 520
Query: 396 RVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMA 455
R LE L ++ +++ + W+ E +V+ S + G+ V L +K + ++ G+
Sbjct: 521 RQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQ 580
Query: 456 GRERLAAVNQMVDELIECGH----TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511
ER+ VN + G + + + + EL +L R L SR
Sbjct: 581 A-ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRR 639
Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVR 568
L KFF + E +G I EK ++ + + +S+ R L RAFE ++
Sbjct: 640 LWKFFWEMAEEEGWIREKE----KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFE 695
Query: 569 Q-LQEGAAQLRTVYAGEHAEAIASREQEVLQGWKEL--LSACEDARLHVSSTADALRFHS 625
Q ++EG + + G +E I R + + W L LSA RL +S +F +
Sbjct: 696 QAIKEGEDMIAEEHFG--SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH--QFQA 751
Query: 626 QVRDLLSWMDGIASQIGAAD 645
D+ +WM I + ++D
Sbjct: 752 DADDIDAWMLDILKIVSSSD 771
Score = 95.9 bits (237), Expect = 1e-19
Identities = 93/464 (20%), Positives = 200/464 (43%), Gaps = 22/464 (4%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+HQ + E + ++ + + L+ + + + + ++ + +A L+ + +
Sbjct: 1633 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRG 1692
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+L E + QL + +L++ + E + G D V ++ + E+ R
Sbjct: 1693 KLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTM-------LQERFREFAR 1745
Query: 141 EVGELQAQTAALPLEPASKELVG----------ERQNAVGERLVRLLEPLQERRRLLLAS 190
+ G + Q + + EL+ E ++ + E LLE + R ++L AS
Sbjct: 1746 DTGNI-GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAAS 1804
Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
ELH+ HD + +Q++ + E G V+ + + +IQA G ++ ++
Sbjct: 1805 YELHKFYHDAKEIFGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQL 1863
Query: 251 LERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
E A L A+ +A+ +++ ++ AW L +A E R+ L +++ V ++
Sbjct: 1864 QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDL 1923
Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
W+ + + +++K +D S L+ H ++ ++ +S ++LL H
Sbjct: 1924 MLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHY 1983
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
SE+I + Q+ + + E+R L ++Q SR S E W+ +E S
Sbjct: 1984 ASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSR 2043
Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD-ELIE 472
E+GQ + V L ++ F ++ ER +A+ ++ EL+E
Sbjct: 2044 EIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLE 2086
Score = 85.5 bits (210), Expect = 1e-16
Identities = 79/385 (20%), Positives = 162/385 (42%), Gaps = 10/385 (2%)
Query: 33 KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLV 92
+E ++ + +L+ AA++ + + + WA+L + + L + + +
Sbjct: 1752 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFY 1811
Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152
E+ ++ +L + + G D TV + + + E ++ +V +LQ A L
Sbjct: 1812 HDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL 1870
Query: 153 PLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQER 210
A + + +R+N V E LL+ + RR L+ + + + + D + W+++
Sbjct: 1871 QAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDV 1930
Query: 211 LPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR 270
+ E+ + +V+ + +QG++ EI A +E +L + + +E ++
Sbjct: 1931 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1990
Query: 271 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQ 330
L QL + + E R + L +V Q+ D + EAWL QE + S + G+
Sbjct: 1991 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD 2050
Query: 331 STLQLLKKHLQLEQGVENYEESIAQLSR-QCRALLEMGHPDSEQISRRQSQVDRLYVALK 389
+L+K+H E+ ++E + L R LLE+ E+ +R+ +
Sbjct: 2051 EVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2110
Query: 390 ELGEERRVALEQQYWLYQLSRQVSE 414
E E QQ W QVS+
Sbjct: 2111 EEAE------SQQQWDTSKGEQVSQ 2129
Score = 30.0 bits (66), Expect = 7.3
Identities = 48/291 (16%), Positives = 107/291 (36%), Gaps = 20/291 (6%)
Query: 364 LEMGHPDSEQISRRQ-------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 416
+ + HPD + I S++ L V K +G+ A+E + + + S+L
Sbjct: 256 ISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL 315
Query: 417 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS---ETGMAGRERLAAVNQMVDELIEC 473
WI + ++ + + V + F+ + + + L + + +
Sbjct: 316 EWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRA 375
Query: 474 GHTAAATMAEWK--DGLNEAW-----AELLELMGTRAQLLAASR--ELHKFFSDARELQG 524
+ E K +N+AW AE + R +L+ + +L + F ++
Sbjct: 376 NNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRE 435
Query: 525 QIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGE 584
+ +RL P+ + + A E D+ +V+ + A +L +
Sbjct: 436 TWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHD 495
Query: 585 HAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635
+ I +R+ V++ W+ LL R + + ++ ++ WMD
Sbjct: 496 -IKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMD 545
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 577 bits (1488), Expect = e-165
Identities = 304/653 (46%), Positives = 424/653 (64%), Gaps = 8/653 (1%)
Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
+L ++D + ++ LH +WL+HQAF+AELA ++ WLE I+ EG+QLM EKP+ A V +K
Sbjct: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQK 1353
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
L + + W EL++TT+ K + L A +D +Q+ A+L+K + ME QL+ DPG DL +
Sbjct: 1354 LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTS 1413
Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
VN L KL+ +E QV E+GEL AQ P+ E G+ ++ +R + LLEPL
Sbjct: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQV------PSMGEEGGDADLSIEKRFLDLLEPL 1467
Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
R++ L +S+ Q++ DL+DE WV+ERLPLA + G LQ VQ +KKNQ L+ EI
Sbjct: 1468 GRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEI 1527
Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
H PR+E+VL+R L + + + L LQS+W LREAA R Q L A + +
Sbjct: 1528 LGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQ 1587
Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
QYY D E EAW+GEQEL ++S++ KDE+ + +LK+HL+ ++ VE+Y +I QL+ +
Sbjct: 1588 QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA 1647
Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
+ LL GHP+ EQI R Q QVD+ Y LK++ EER+ LE Y L+QL R+ +LE WI+
Sbjct: 1648 QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWIS 1707
Query: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480
EKE+VA SPE+GQDF+HV++L++KF +FA ETG G+ER+ VN ++ LI+ GH+ AAT
Sbjct: 1708 EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT 1767
Query: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540
+AEWKDGLNE WA+LLEL+ TR QLLAAS +LH++F E+ G I+EK R LP
Sbjct: 1768 IAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE--DVG 1825
Query: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600
+A S R AFE +L LL QV+Q Q+ A +L+T YAGE AEAI ++EQEV W
Sbjct: 1826 LDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAW 1885
Query: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653
+ LL AC R + TAD RF S RDLLSWM+ I QI ++PR SS+
Sbjct: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSV 1938
Score = 161 bits (407), Expect = 2e-39
Identities = 131/650 (20%), Positives = 274/650 (42%), Gaps = 7/650 (1%)
Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
L+A+D D + +H+A + A +E + +E Q+L +E + +
Sbjct: 444 LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503
Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
I + W+ L+ Q++ ++L +L Q + +++ L + G L V
Sbjct: 504 DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALP----LEPASKELVGERQNAVGERLVRLL 177
L+K + ME+ + +V + A T +P +++ +R + + + L
Sbjct: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
Query: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237
R+ L SK L + ++D+ +W++E+ + + G L +V +K++
Sbjct: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
Query: 238 REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297
E++ LE++ + A + + + + ++++ + W L++ A ++ L A
Sbjct: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAE 743
Query: 298 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357
Q+ D +++AWL + L+ ED G+DE +T L KKH + +E + L
Sbjct: 744 NFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLE 803
Query: 358 RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEH 417
+Q + E DS ++ R + LY + + R+ L++ LY + + E
Sbjct: 804 QQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACEL 862
Query: 418 WIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTA 477
W+ EKE E+ E + V+Q +F E ++ VN + L+E GH
Sbjct: 863 WMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL-MTQIDGVNLAANSLVESGHPR 921
Query: 478 AATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537
+ + +++D LN W L+ R + + ++ +H + D E I +K + +
Sbjct: 922 SREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK 981
Query: 538 TPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL 597
++QR L E D+ + ++V L+ + QL + E E I R++ +
Sbjct: 982 DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLE 1040
Query: 598 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647
+ W+ L + + + + F + D +W+ + + D P
Sbjct: 1041 ELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMP 1090
Score = 105 bits (261), Expect = 2e-22
Identities = 125/664 (18%), Positives = 278/664 (41%), Gaps = 42/664 (6%)
Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
L++ + +D +H+ F+ EL +++ +E +E++ Q +E + + V +L
Sbjct: 765 LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRD-SPDVTHRL 823
Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM---ESQLQDVDPGGDL 118
+R+ + ++ + + ++L EA L F E D L M E L +++ L
Sbjct: 824 QALRELYQQVVAQADLRQQRLQEAL---DLYTVFGETDACELWMGEKEKWLAEMEMPDTL 880
Query: 119 ATVNSQLKKLQSMESQVEEWYREVG--ELQAQTAALPLEPASKELVGERQNAVGERLVRL 176
+ + ++ +++ ++ L A + P S+E V + Q+ + R
Sbjct: 881 EDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE-VKQYQDHLNTRWQAF 939
Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT-ERGNGLQAVQQHIKKNQG 235
+ ERR + ++ +H D ++ W+ ++ + T + G L + +K G
Sbjct: 940 QTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999
Query: 236 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 295
L R++ A R++ + + L + E + + + L+ W GL+++ + ++ +L
Sbjct: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGE 1059
Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 355
Q++ + D+ + +AWL + + SED + QLL++H ++ ++ +++S +
Sbjct: 1060 VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQR 1119
Query: 356 LSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVS 413
+ +++ G D E + +R +D + AL + E R L Q + +
Sbjct: 1120 VKESGEKVIQ-GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK 1178
Query: 414 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 473
+ E ++ +E E E KF +F R+++ + ++L+
Sbjct: 1179 QAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSM-ENNRDKVLSPVDSGNKLVAE 1237
Query: 474 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 533
G+ + + E + + + E + LL + EL F + +EL I +K
Sbjct: 1238 GNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK---- 1293
Query: 534 PRLTTPPEPRPSASSMQR----------TLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAG 583
LT+ A ++ L + E L+ + ++ +QL + Q
Sbjct: 1294 -LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQF------ 1346
Query: 584 EHAEAIASREQEVLQG-WKELLSACEDARLHVSSTADA-LRFHSQVRDLLSWMDGIASQI 641
A+ S++ E L W EL + ++ H+S+ + LR + DL W+ + Q+
Sbjct: 1347 ---TALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQL 1402
Query: 642 GAAD 645
+ D
Sbjct: 1403 RSDD 1406
Score = 95.9 bits (237), Expect = 1e-19
Identities = 111/483 (22%), Positives = 206/483 (42%), Gaps = 28/483 (5%)
Query: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229
G+R+ ++++ E +++ ++ +A DL L W+++ + + + N L VQQ
Sbjct: 287 GKRVGKVIDHAIETEKMI---EKYSGLASDL---LTWIEQTITVLNSRKFANSLTGVQQQ 340
Query: 230 IKKNQGLRR-----EIQAHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGL 282
++ R + Q G LE +L + + + G + + AW L
Sbjct: 341 LQAFSTYRTVEKPPKFQEKG-NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESL 399
Query: 283 REAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQ 334
EA RR+ L ++EQ FD A E WL E + L+ ++ G D +
Sbjct: 400 EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEA 459
Query: 335 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394
KKH +E YEE + L + L + + D ++I+ R+ + RL+ L+EL +
Sbjct: 460 AKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQS 519
Query: 395 RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454
RR LE L +L + + W+ E + S E G+ V L +K ++ +
Sbjct: 520 RRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAI 579
Query: 455 AGRERLAAVNQMVDELIE-CGHTAA--ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511
G +++ A+ + E G+ + + L + + EL + R L S+
Sbjct: 580 QG-DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKR 638
Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571
L KFF + E + I+EK + L + S +QR +AFE +L+ L + + Q+
Sbjct: 639 LWKFFWEMDEAESWIKEKEQIYSSLDYGKD-LTSVLILQRKHKAFEDELRGLDAHLEQIF 697
Query: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631
+ A + H + I +R +EV W +L + ++ + +F DL
Sbjct: 698 QEAHGMVARKQFGHPQ-IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
Query: 632 SWM 634
+W+
Sbjct: 757 AWL 759
Score = 87.8 bits (216), Expect = 3e-17
Identities = 98/455 (21%), Positives = 196/455 (43%), Gaps = 14/455 (3%)
Query: 17 KRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ 76
KR LR Q + + +N ++++ Q L+ + + G++ + +A L+ +
Sbjct: 1624 KRHLRQQRAVEDYGRN---IKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680
Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136
+ R+L QL + +L++ + E + G D V K + +
Sbjct: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740
Query: 137 EWYRE-VGELQAQTAALPLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKEL 193
+E V + A L ++ E + E ++ + E LLE + R +LL AS +L
Sbjct: 1741 AIGQERVDNVNAFIERL-IDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDL 1799
Query: 194 HQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253
H+ + + L + E+ + + G + + + RE+ G ++++ +
Sbjct: 1800 HRYFYTGAEILGLIDEK-HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858
Query: 254 AGALASLRSPE-AEAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVA-EVE 310
A L + + E AEA++ +++ +AW L +A A RR Q++D A + +F +A ++
Sbjct: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFR--FFSMARDLL 1916
Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
+W+ + ++++ +D S L+K H + +E ++ + +LL+ H
Sbjct: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430
SE+I + QV + E E R L + Q SR S E W+ +E S +
Sbjct: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
Query: 431 LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 465
G + V L ++ F T + ER AA+ +
Sbjct: 2037 FGHTVDSVEKLIKRHEAFEKSTA-SWAERFAALEK 2070
Score = 37.7 bits (86), Expect = 0.035
Identities = 25/128 (19%), Positives = 52/128 (40%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81
HQ AE+ + G+ L+Q + + + +R+KL ++ E+ +A+ +
Sbjct: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWER 2004
Query: 82 LFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYRE 141
L + Q + + + L+ E L D G + +V +K+ ++ E W
Sbjct: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064
Query: 142 VGELQAQT 149
L+ T
Sbjct: 2065 FAALEKPT 2072
Score = 35.8 bits (81), Expect = 0.13
Identities = 51/279 (18%), Positives = 106/279 (37%), Gaps = 13/279 (4%)
Query: 379 SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 438
S++ L V K +G+ A+E + + + S S+L WI + V S + V
Sbjct: 278 SKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGV 337
Query: 439 SVLQEKFSEFAS---ETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK--DGLNEAWA 493
+ FS + + + L + + + + T + K +N AW
Sbjct: 338 QQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWE 397
Query: 494 ELLEL-----MGTRAQLLAASR--ELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSA 546
L E + R +L+ + +L + F ++ + +RL +
Sbjct: 398 SLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAV 457
Query: 547 SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA 606
+ ++ A E D +VR L++ A +L + + I +R+ +L+ W L
Sbjct: 458 EAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-KRITARKDNILRLWSYLQEL 516
Query: 607 CEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
+ R + +T + + + WMD I + + +A+
Sbjct: 517 LQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAE 555
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 577 bits (1488), Expect = e-165
Identities = 304/653 (46%), Positives = 424/653 (64%), Gaps = 8/653 (1%)
Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
+L ++D + ++ LH +WL+HQAF+AELA ++ WLE I+ EG+QLM EKP+ A V +K
Sbjct: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQK 1353
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
L + + W EL++TT+ K + L A +D +Q+ A+L+K + ME QL+ DPG DL +
Sbjct: 1354 LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTS 1413
Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
VN L KL+ +E QV E+GEL AQ P+ E G+ ++ +R + LLEPL
Sbjct: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQV------PSMGEEGGDADLSIEKRFLDLLEPL 1467
Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
R++ L +S+ Q++ DL+DE WV+ERLPLA + G LQ VQ +KKNQ L+ EI
Sbjct: 1468 GRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEI 1527
Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
H PR+E+VL+R L + + + L LQS+W LREAA R Q L A + +
Sbjct: 1528 LGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQ 1587
Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
QYY D E EAW+GEQEL ++S++ KDE+ + +LK+HL+ ++ VE+Y +I QL+ +
Sbjct: 1588 QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA 1647
Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
+ LL GHP+ EQI R Q QVD+ Y LK++ EER+ LE Y L+QL R+ +LE WI+
Sbjct: 1648 QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWIS 1707
Query: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480
EKE+VA SPE+GQDF+HV++L++KF +FA ETG G+ER+ VN ++ LI+ GH+ AAT
Sbjct: 1708 EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT 1767
Query: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540
+AEWKDGLNE WA+LLEL+ TR QLLAAS +LH++F E+ G I+EK R LP
Sbjct: 1768 IAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE--DVG 1825
Query: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600
+A S R AFE +L LL QV+Q Q+ A +L+T YAGE AEAI ++EQEV W
Sbjct: 1826 LDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAW 1885
Query: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653
+ LL AC R + TAD RF S RDLLSWM+ I QI ++PR SS+
Sbjct: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSV 1938
Score = 161 bits (407), Expect = 2e-39
Identities = 131/650 (20%), Positives = 274/650 (42%), Gaps = 7/650 (1%)
Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
L+A+D D + +H+A + A +E + +E Q+L +E + +
Sbjct: 444 LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503
Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
I + W+ L+ Q++ ++L +L Q + +++ L + G L V
Sbjct: 504 DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALP----LEPASKELVGERQNAVGERLVRLL 177
L+K + ME+ + +V + A T +P +++ +R + + + L
Sbjct: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
Query: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237
R+ L SK L + ++D+ +W++E+ + + G L +V +K++
Sbjct: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
Query: 238 REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297
E++ LE++ + A + + + + ++++ + W L++ A ++ L A
Sbjct: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAE 743
Query: 298 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357
Q+ D +++AWL + L+ ED G+DE +T L KKH + +E + L
Sbjct: 744 NFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLE 803
Query: 358 RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEH 417
+Q + E DS ++ R + LY + + R+ L++ LY + + E
Sbjct: 804 QQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACEL 862
Query: 418 WIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTA 477
W+ EKE E+ E + V+Q +F E ++ VN + L+E GH
Sbjct: 863 WMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL-MTQIDGVNLAANSLVESGHPR 921
Query: 478 AATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537
+ + +++D LN W L+ R + + ++ +H + D E I +K + +
Sbjct: 922 SREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK 981
Query: 538 TPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL 597
++QR L E D+ + ++V L+ + QL + E E I R++ +
Sbjct: 982 DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLE 1040
Query: 598 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647
+ W+ L + + + + F + D +W+ + + D P
Sbjct: 1041 ELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMP 1090
Score = 105 bits (261), Expect = 2e-22
Identities = 125/664 (18%), Positives = 278/664 (41%), Gaps = 42/664 (6%)
Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
L++ + +D +H+ F+ EL +++ +E +E++ Q +E + + V +L
Sbjct: 765 LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRD-SPDVTHRL 823
Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM---ESQLQDVDPGGDL 118
+R+ + ++ + + ++L EA L F E D L M E L +++ L
Sbjct: 824 QALRELYQQVVAQADLRQQRLQEAL---DLYTVFGETDACELWMGEKEKWLAEMEMPDTL 880
Query: 119 ATVNSQLKKLQSMESQVEEWYREVG--ELQAQTAALPLEPASKELVGERQNAVGERLVRL 176
+ + ++ +++ ++ L A + P S+E V + Q+ + R
Sbjct: 881 EDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE-VKQYQDHLNTRWQAF 939
Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT-ERGNGLQAVQQHIKKNQG 235
+ ERR + ++ +H D ++ W+ ++ + T + G L + +K G
Sbjct: 940 QTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999
Query: 236 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 295
L R++ A R++ + + L + E + + + L+ W GL+++ + ++ +L
Sbjct: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGE 1059
Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 355
Q++ + D+ + +AWL + + SED + QLL++H ++ ++ +++S +
Sbjct: 1060 VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQR 1119
Query: 356 LSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVS 413
+ +++ G D E + +R +D + AL + E R L Q + +
Sbjct: 1120 VKESGEKVIQ-GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK 1178
Query: 414 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 473
+ E ++ +E E E KF +F R+++ + ++L+
Sbjct: 1179 QAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSM-ENNRDKVLSPVDSGNKLVAE 1237
Query: 474 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 533
G+ + + E + + + E + LL + EL F + +EL I +K
Sbjct: 1238 GNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK---- 1293
Query: 534 PRLTTPPEPRPSASSMQR----------TLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAG 583
LT+ A ++ L + E L+ + ++ +QL + Q
Sbjct: 1294 -LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQF------ 1346
Query: 584 EHAEAIASREQEVLQG-WKELLSACEDARLHVSSTADA-LRFHSQVRDLLSWMDGIASQI 641
A+ S++ E L W EL + ++ H+S+ + LR + DL W+ + Q+
Sbjct: 1347 ---TALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQL 1402
Query: 642 GAAD 645
+ D
Sbjct: 1403 RSDD 1406
Score = 95.9 bits (237), Expect = 1e-19
Identities = 111/483 (22%), Positives = 206/483 (42%), Gaps = 28/483 (5%)
Query: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229
G+R+ ++++ E +++ ++ +A DL L W+++ + + + N L VQQ
Sbjct: 287 GKRVGKVIDHAIETEKMI---EKYSGLASDL---LTWIEQTITVLNSRKFANSLTGVQQQ 340
Query: 230 IKKNQGLRR-----EIQAHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGL 282
++ R + Q G LE +L + + + G + + AW L
Sbjct: 341 LQAFSTYRTVEKPPKFQEKG-NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESL 399
Query: 283 REAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQ 334
EA RR+ L ++EQ FD A E WL E + L+ ++ G D +
Sbjct: 400 EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEA 459
Query: 335 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394
KKH +E YEE + L + L + + D ++I+ R+ + RL+ L+EL +
Sbjct: 460 AKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQS 519
Query: 395 RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454
RR LE L +L + + W+ E + S E G+ V L +K ++ +
Sbjct: 520 RRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAI 579
Query: 455 AGRERLAAVNQMVDELIE-CGHTAA--ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511
G +++ A+ + E G+ + + L + + EL + R L S+
Sbjct: 580 QG-DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKR 638
Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571
L KFF + E + I+EK + L + S +QR +AFE +L+ L + + Q+
Sbjct: 639 LWKFFWEMDEAESWIKEKEQIYSSLDYGKD-LTSVLILQRKHKAFEDELRGLDAHLEQIF 697
Query: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631
+ A + H + I +R +EV W +L + ++ + +F DL
Sbjct: 698 QEAHGMVARKQFGHPQ-IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
Query: 632 SWM 634
+W+
Sbjct: 757 AWL 759
Score = 87.8 bits (216), Expect = 3e-17
Identities = 98/455 (21%), Positives = 196/455 (43%), Gaps = 14/455 (3%)
Query: 17 KRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ 76
KR LR Q + + +N ++++ Q L+ + + G++ + +A L+ +
Sbjct: 1624 KRHLRQQRAVEDYGRN---IKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680
Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136
+ R+L QL + +L++ + E + G D V K + +
Sbjct: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740
Query: 137 EWYRE-VGELQAQTAALPLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKEL 193
+E V + A L ++ E + E ++ + E LLE + R +LL AS +L
Sbjct: 1741 AIGQERVDNVNAFIERL-IDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDL 1799
Query: 194 HQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253
H+ + + L + E+ + + G + + + RE+ G ++++ +
Sbjct: 1800 HRYFYTGAEILGLIDEK-HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858
Query: 254 AGALASLRSPE-AEAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVA-EVE 310
A L + + E AEA++ +++ +AW L +A A RR Q++D A + +F +A ++
Sbjct: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFR--FFSMARDLL 1916
Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
+W+ + ++++ +D S L+K H + +E ++ + +LL+ H
Sbjct: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430
SE+I + QV + E E R L + Q SR S E W+ +E S +
Sbjct: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
Query: 431 LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 465
G + V L ++ F T + ER AA+ +
Sbjct: 2037 FGHTVDSVEKLIKRHEAFEKSTA-SWAERFAALEK 2070
Score = 37.7 bits (86), Expect = 0.035
Identities = 25/128 (19%), Positives = 52/128 (40%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81
HQ AE+ + G+ L+Q + + + +R+KL ++ E+ +A+ +
Sbjct: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWER 2004
Query: 82 LFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYRE 141
L + Q + + + L+ E L D G + +V +K+ ++ E W
Sbjct: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064
Query: 142 VGELQAQT 149
L+ T
Sbjct: 2065 FAALEKPT 2072
Score = 35.8 bits (81), Expect = 0.13
Identities = 51/279 (18%), Positives = 106/279 (37%), Gaps = 13/279 (4%)
Query: 379 SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 438
S++ L V K +G+ A+E + + + S S+L WI + V S + V
Sbjct: 278 SKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGV 337
Query: 439 SVLQEKFSEFAS---ETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK--DGLNEAWA 493
+ FS + + + L + + + + T + K +N AW
Sbjct: 338 QQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWE 397
Query: 494 ELLEL-----MGTRAQLLAASR--ELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSA 546
L E + R +L+ + +L + F ++ + +RL +
Sbjct: 398 SLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAV 457
Query: 547 SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA 606
+ ++ A E D +VR L++ A +L + + I +R+ +L+ W L
Sbjct: 458 EAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-KRITARKDNILRLWSYLQEL 516
Query: 607 CEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
+ R + +T + + + WMD I + + +A+
Sbjct: 517 LQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAE 555
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 531 bits (1367), Expect = e-150
Identities = 290/653 (44%), Positives = 414/653 (63%), Gaps = 10/653 (1%)
Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
ML A+D + ++ LH +W +HQAFMAELA NK+WL+K+++EG++L EKPEL A V +K
Sbjct: 1298 MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK 1357
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
L ++ + W ELE+TTQAKAR LF+A++A+ QS L+ L +++QL D G DL +
Sbjct: 1358 LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTS 1417
Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
VN LKK Q +E ++ +EV +QAQ AL E V AV E+ L +P+
Sbjct: 1418 VNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPM 1477
Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
+ER R L AS+E HQ D++DE+ WV ERLP+A E G L +VQ +KKNQ L++EI
Sbjct: 1478 RERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEI 1537
Query: 241 QAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV 299
Q H PR+ ++ ER AL A+ PE L +LQ W L E R + L+ A +
Sbjct: 1538 QGHEPRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRGKRLEDALRA 1590
Query: 300 EQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ 359
+Q+Y D AE EAW+GEQEL MM ++K KDE S +KKH LEQ + +Y ++I QL+
Sbjct: 1591 QQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAAS 1650
Query: 360 CRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419
+ +++ HP+S +IS RQ+QVD+LY LKEL ERR L++ L QL R++ +LE WI
Sbjct: 1651 SQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710
Query: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479
E+EVVA S ELGQD+EHV++L++KF EF+ +T G+ER+ + N + + LI GH A A
Sbjct: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770
Query: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539
T+AEWKD LNEAWA+LLEL+ TR Q+LAA+ EL +F AR+ +++ K+++LP T
Sbjct: 1771 TVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGT-- 1828
Query: 540 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599
+A ++QR A+EHD+Q L QV+Q+Q+ +L+ YAG+ AE I Q V +
Sbjct: 1829 GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEA 1888
Query: 600 WKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSS 652
W +L + R + T D RF VR+L+ WMD + Q+ A ++PR SS
Sbjct: 1889 WAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSS 1941
Score = 151 bits (381), Expect = 2e-36
Identities = 136/593 (22%), Positives = 254/593 (42%), Gaps = 29/593 (4%)
Query: 61 LGEIRQCWAELESTTQAKARQL-FEASKADQLVQSFAELDKKLLHMESQLQDVDP----- 114
+ +I + W LE + L E + ++L Q A D+K E+ L +
Sbjct: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
Query: 115 --GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK-ELVGERQNAVGE 171
G +LA V + ++K +++E+ + + V + A A L E + + RQ+ V
Sbjct: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
Query: 172 RLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIK 231
L + + RR LL + EL +V DL + W++E + G L V+ ++
Sbjct: 512 LWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQ 571
Query: 232 KNQGLRREIQAHGPRLEEVLERAGALAS----LRSPEAEAVRRGLEQLQSAWAGLREAAE 287
++ + +I R+ V A + R + + V + +L+ ++ L E A
Sbjct: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
Query: 288 RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVE 347
R+ L+ + ++ ++ ++V E EAW+ EQ+ L+ S D G+D L+LL KH L +
Sbjct: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691
Query: 348 NYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQ 407
+ Q + L+ GHP + Q S R +++ + L+ L EER L Q LYQ
Sbjct: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751
Query: 408 LSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467
+++E W+ + + SPELG D E ++ + A E + + +
Sbjct: 752 FQADANDMEAWLVDALRLVSSPELGHD--------EFSTQALARQHRALEEEIRSHRPTL 803
Query: 468 DELIECGHTAAATMAEWKD------GLNEAWAELLELMGTRAQLLAASRELHKFFSDARE 521
D L E T++ + L + EL G RA+ L A+ L+ S+A
Sbjct: 804 DALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGA 863
Query: 522 LQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVY 581
+EEK + L L PE +Q+ E ++ L +Q+ + + A QL
Sbjct: 864 CGLWVEEKEQWLNGLAL-PERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKAN 922
Query: 582 AGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWM 634
+ I + ++++ W++ + + ++S +H + + +WM
Sbjct: 923 P-PGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWM 974
Score = 125 bits (315), Expect = 1e-28
Identities = 132/623 (21%), Positives = 248/623 (39%), Gaps = 17/623 (2%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+H A E++ L+ +GQQL+ E A+ + E++ W LE+ + +A+
Sbjct: 682 KHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQ 741
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+L +A+ Q +++ L+ + + G D + + ++ +++E ++
Sbjct: 742 RLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRP 801
Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL 200
+ L+ Q AALP + V R + L ER R L A+ L+ + +
Sbjct: 802 TLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEA 861
Query: 201 DDELAWVQER---LPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 257
WV+E+ L ER L+ VQQ + L E+ ++ V + A L
Sbjct: 862 GACGLWVEEKEQWLNGLALPERLEDLEVVQQRF---ETLEPEMNTLAAQITAVNDIAEQL 918
Query: 258 ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQ- 316
P + + EQL W R A+ ++ L +A ++ Y+ + E +AW+ E+
Sbjct: 919 LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKT 978
Query: 317 ELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP-DSEQIS 375
+++ ++ G D L L +K E+ +E + +L+R+ A L GHP + I+
Sbjct: 979 KVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANA-LAAGHPAQAVAIN 1037
Query: 376 RRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDF 435
R +V + L+ R +L + L R + + + W+ + S E
Sbjct: 1038 ARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATL 1097
Query: 436 EHVSVLQEKFSEFASETGMAGRE--RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWA 493
L + + E A E RL A+ + V + + + + L W
Sbjct: 1098 PEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR--DQADPQCLFLRQRLEALGTGWE 1155
Query: 494 ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL 553
EL + +R LA + F DAR+ +G + + L T P +A + + L
Sbjct: 1156 ELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSH-TEMPGTLQAADAAIKKL 1214
Query: 554 RAFEHDLQLLVSQVRQLQEGAAQLRTVYAGE-HAEAIASREQEVLQGWKELLSACEDARL 612
F + ++ L E QL V G HA+ I + + + K+ A +
Sbjct: 1215 EDFMSTMDANGERIHGLLEAGRQL--VSEGNIHADKIREKADSIERRHKKNQDAAQQFLG 1272
Query: 613 HVSSTADALRFHSQVRDLLSWMD 635
+ + F +L W+D
Sbjct: 1273 RLRDNREQQHFLQDCHELKLWID 1295
Score = 108 bits (269), Expect = 2e-23
Identities = 135/640 (21%), Positives = 269/640 (42%), Gaps = 32/640 (5%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQL---MQEKPELAASVRKKLGEIRQCWAELESTTQA 77
+H+A E+ ++ L+ + + L + PE V+ ++ + + + EL++
Sbjct: 788 QHRALEEEIRSHRPTLDALREQAAALPPTLSRTPE----VQGRVPTLERHYEELQARAGE 843
Query: 78 KARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEE 137
+AR L EA+ A L +E L +E + Q ++ + +L+ L+ ++ + E
Sbjct: 844 RARAL-EAALA--LYTMLSEAGACGLWVEEKEQWLNG----LALPERLEDLEVVQQRFET 896
Query: 138 WYREVGELQAQTAA--------LPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLA 189
E+ L AQ A L P K+ + Q + R + ++ L +
Sbjct: 897 LEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTS 956
Query: 190 SKELHQVAHDLDDELAWVQERLPLAMQTER-GNGLQAVQQHIKKNQGLRREIQAHGPRLE 248
+ + + + AW++E+ + T+ GN L V +K G R+++A R+
Sbjct: 957 ALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVG 1016
Query: 249 EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 308
E+ A ALA+ +A A+ L ++Q+ W LR RR++ L A +++ + + +
Sbjct: 1017 ELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDD 1076
Query: 309 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 368
+AWLG + + SE+ LL +H L VE + ++L R +
Sbjct: 1077 FQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL-RALGEEVTRDQ 1135
Query: 369 PDSEQISRRQSQVDRLYVALKELG---EERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425
D + + RQ +++ L +ELG E R+ L Q + R + E ++ +E V
Sbjct: 1136 ADPQCLFLRQ-RLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYV 1194
Query: 426 AGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485
E+ + +K +F S T A ER+ + + +L+ G+ A + E
Sbjct: 1195 LSHTEMPGTLQAADAAIKKLEDFMS-TMDANGERIHGLLEAGRQLVSEGNIHADKIREKA 1253
Query: 486 DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS 545
D + + + L +RE F D EL+ I+EK ++ E R
Sbjct: 1254 DSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSY-DEARNL 1312
Query: 546 ASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLS 605
+ Q+ +AF +L + ++ + +L T+ E ++ + +++ + W EL +
Sbjct: 1313 HTKWQKH-QAFMAELAANKDWLDKVDKEGREL-TLEKPELKALVSEKLRDLHRRWDELET 1370
Query: 606 ACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
+ + A F L SW++ + +Q+ + D
Sbjct: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDD 1410
Score = 104 bits (259), Expect = 3e-22
Identities = 144/648 (22%), Positives = 251/648 (38%), Gaps = 73/648 (11%)
Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93
E + K+E+ + L ELAA+ R +L E R+ W R L+E +A+ V+
Sbjct: 614 ERVAKLEQSYEALC----ELAAARRARLEESRRLW-----------RFLWEVGEAEAWVR 658
Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 153
L L D G DL L K ++ GE+ + L
Sbjct: 659 EQQHL----------LASADTGRDLTGALRLLNKHTALR----------GEMSGRLGPLK 698
Query: 154 LE-PASKELVGERQNAVGERLVRL---------LEPL-QERRRLLLASKELHQVAHDLDD 202
L ++LV E + R LE L +ER + L + L+Q D +D
Sbjct: 699 LTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADAND 758
Query: 203 ELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL-- 260
AW+ + L L E G+ + Q ++++ L EI++H P L+ + E+A AL
Sbjct: 759 MEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLS 818
Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320
R+PE V+ + L+ + L+ A R + L+AA + + W+ E+E +
Sbjct: 819 RTPE---VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWL 875
Query: 321 MSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380
+ + + ++ LE + I ++ LL+ P ++I Q Q
Sbjct: 876 NGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQ 935
Query: 381 VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK-EVVAGSPELGQDFEHVS 439
++ + + L + ++ AL + + +E + W+ EK +V+ + LG D V
Sbjct: 936 LNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVL 995
Query: 440 VLQEKFSEFASETGMAGRER-LAAVNQMVDEL------IECGHTAAATMAEWK-DGLNEA 491
LQ K +AG ER L A+ V EL + GH A A + +
Sbjct: 996 ALQRK---------LAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTG 1046
Query: 492 WAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQR 551
W +L M R + L +R L F + Q + + + P P A ++
Sbjct: 1047 WEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS-EEGPATLPEAEALLA 1105
Query: 552 TLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDAR 611
A +++ S+ +L+ ++ A + R + + GW+EL E +
Sbjct: 1106 QHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQ 1165
Query: 612 LHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGLPAS 659
A A F +RD ++SQ P +L A+
Sbjct: 1166 ---GRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAA 1210
Score = 104 bits (259), Expect = 3e-22
Identities = 124/563 (22%), Positives = 221/563 (39%), Gaps = 81/563 (14%)
Query: 54 AASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD 113
AA+ +L E+++ W L + + ++L +A +A Q + AE + + E + +
Sbjct: 1556 AAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQE 1615
Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTA-ALPLEPASKELVGERQNAVGER 172
D + +++KK Q +E + ++ + + +L A + + E + RQ V +
Sbjct: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKL 1675
Query: 173 LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKK 232
L E ERR L L Q+ +LDD W+QER +A E G + V K
Sbjct: 1676 YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDK 1735
Query: 233 NQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGL----EQLQSAWAGLREAAER 288
+ R+ G +E ++ A ALA+ A R + + L AWA L E +
Sbjct: 1736 FREFSRDTSTIG---QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDT 1792
Query: 289 RQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 348
R QVL AA++++++ + A + ++ + + G+D + L ++H
Sbjct: 1793 RGQVLAAAYELQRFLHGARQALARVQHKQQ-QLPDGTGRDLNAAEALQRRHCA------- 1844
Query: 349 YEESIAQLSRQCRALLEMGH--------PDSEQISRRQSQVDRLYVALKELGEERRVALE 400
YE I LS Q + + + GH +E+I R V + L+ RR L
Sbjct: 1845 YEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLL 1904
Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460
++ + V EL W+ E + + E +D ++ + +E A +R
Sbjct: 1905 DTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIE-ARADRF 1963
Query: 461 AAVNQMVDELIECGHTAAATMAE---------------WKD------------------G 487
++ M EL+ H AA ++E W++ G
Sbjct: 1964 SSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAG 2023
Query: 488 LNEAWAELLELMGTRAQLLAASREL------HKFFSDA-----------------RELQG 524
+ EAW E + A+L E+ H+ F + E +
Sbjct: 2024 MAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREK 2083
Query: 525 QIEEKRRRLPRLTTPPEPRPSAS 547
+ + KR R PP P P+AS
Sbjct: 2084 ERKRKREEEERRKQPPAPEPTAS 2106
Score = 99.0 bits (245), Expect = 1e-20
Identities = 94/449 (20%), Positives = 192/449 (42%), Gaps = 5/449 (1%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+HQ LA + + ++ Q ++ + + + + ++ + +A L+ +
Sbjct: 1629 KHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRE 1688
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+L E + QL + +L++ + E + G D V K + +
Sbjct: 1689 RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQ 1748
Query: 141 E-VGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH 198
E V A L A++ V E ++++ E LLE L R ++L A+ EL + H
Sbjct: 1749 ERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLH 1808
Query: 199 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258
LA VQ + + G L A + +++ +IQA P++++V + L
Sbjct: 1809 GARQALARVQHKQQ-QLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQ 1867
Query: 259 -SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQE 317
+ +AE + R ++ + AWA L+ ++ R+Q+L +++ V E+ W+ E
Sbjct: 1868 KAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVN 1927
Query: 318 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRR 377
L M ++++ +D S ++K ++ +E + + + LL H +E+IS +
Sbjct: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEK 1987
Query: 378 QSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEH 437
SQ+ E +E+ L+ + R E W+ +E + S ELG +
Sbjct: 1988 LSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDE 2047
Query: 438 VSVLQEKFSEFASETGMAGRERLAAVNQM 466
V L ++ F ++ +A ER A+ ++
Sbjct: 2048 VESLIKRHEAF-QKSAVAWEERFCALEKL 2075
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 269 bits (687), Expect = 7e-72
Identities = 184/643 (28%), Positives = 311/643 (48%), Gaps = 11/643 (1%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
RH+A +EL + +E +++ G++L+ +P ++ +L +R W L +
Sbjct: 1319 RHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+L +A + +QL++ + ++L +E LQ + G DL + K+ Q +ES+
Sbjct: 1379 ELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438
Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL 200
++ L + + PA E E Q + RL L L R L AS ELHQ H
Sbjct: 1439 KMAALASMAHGMAASPAILE---ETQKHL-RRLELLQGHLAIRGLQLQASVELHQFCHLS 1494
Query: 201 DDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL 260
+ EL+WV E +P T L Q +K++ L+ E++AH +++ VL +LA+
Sbjct: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAAS 1554
Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320
P+A+ + ++L+ WA L A E R Q L A +QY+ DV+E+E W+ E+ L+
Sbjct: 1555 GHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLV 1614
Query: 321 MSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380
S D G+DE +TL+L+ KH L++ + Y S+ +L + + L P+ +++ Q +
Sbjct: 1615 SSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVV--QER 1672
Query: 381 VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA-EKEVVAGSPELGQDFEHVS 439
+ AL+EL R LE L++ R+ +L+ W+A +K+ G LG+D EH
Sbjct: 1673 LREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHAL 1732
Query: 440 VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELM 499
L KF++F + M G +R+AA + + L+E GH+A + + + L AW+EL EL
Sbjct: 1733 HLCTKFAKFQHQVEM-GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT 1791
Query: 500 GTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHD 559
R L + + D E+ Q++EK LP + R+ + E +
Sbjct: 1792 QARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP--NNVARDLCGLEAQLRSHQGLERE 1849
Query: 560 LQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTAD 619
L Q+++L E A +++ + G A A+ R+Q V Q W L E R +
Sbjct: 1850 LVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARL 1909
Query: 620 ALRFHSQVRDLLSWMDGIASQIGAADKPRCPSS-LLGLPASPW 661
RF + VRD SW + + + + PSS L L A W
Sbjct: 1910 LARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQW 1952
Score = 248 bits (632), Expect = 2e-65
Identities = 177/624 (28%), Positives = 302/624 (48%), Gaps = 7/624 (1%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70
D L + + Q F AEL + ++++REGQ+L+Q + +++++L E+ W E
Sbjct: 2677 DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGE 2736
Query: 71 LESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQS 130
L+ +Q K +L +A +A +L +S EL+ L +E +L+ G L V L +
Sbjct: 2737 LQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRE 2796
Query: 131 MESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLLA 189
+E+ V++ R+ L Q A E + V E+ + +R L EPLQERR L A
Sbjct: 2797 LEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEA 2856
Query: 190 SKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEE 249
L + D D+E+AWVQE+LPLA + G L AV+ +++Q L E+ +H
Sbjct: 2857 RSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRV 2916
Query: 250 VLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
VL L A V ++QL+ A A LR A RR+ +L A + +Q+ ++ E
Sbjct: 2917 VLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEA 2976
Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
+WL E+ ++ SED G ++T LL++ ++ +E + I +L + L +P
Sbjct: 2977 GSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNP 3036
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
+S ++ + V + L E R L++Q L+QL R+ L+ W+ K A S
Sbjct: 3037 ESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQ 3096
Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489
+ GQD E V VL+EKF F E G+ ++ A+ ++ L + + +
Sbjct: 3097 DYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIE 3156
Query: 490 EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549
AW L + + R + LAA+ E+H F A ELQG+++EK L + S ++
Sbjct: 3157 AAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEK-TALMKGEDGGHSLSSVRTL 3215
Query: 550 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609
Q+ R E +L+ + +V +LQ A +L G+ A +V + W L + ++
Sbjct: 3216 QQQHRRLERELEAMEKEVARLQTEACRL-----GQLHPAAPGGLAKVQEAWATLQAKAQE 3270
Query: 610 ARLHVSSTADALRFHSQVRDLLSW 633
++ A F + ++LL+W
Sbjct: 3271 RGQWLAQAAQGHAFLGRCQELLAW 3294
Score = 150 bits (379), Expect = 4e-36
Identities = 138/638 (21%), Positives = 282/638 (44%), Gaps = 22/638 (3%)
Query: 17 KRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ 76
K L+HQAF AE+ ++E + + ++G+ L+ + A V ++L +R+ W +L
Sbjct: 2151 KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMA 2210
Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM----- 131
+ ++L + + +Q + + E ++ D G DL ++L+
Sbjct: 2211 LRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSA 2270
Query: 132 -ESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLAS 190
++ + R + +L Q +P +++ +R++ + R L ++ L +
Sbjct: 2271 GDTVGDACIRSISDLSLQLK--NRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGA 2328
Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
E+H ++ +LD+ +QE+ L + G L++VQ+ ++K++ L RE+ ++E +
Sbjct: 2329 LEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388
Query: 251 LERAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
G L RSPE A +R +++ +W LR A++R++ LDA Q ++ + E+
Sbjct: 2389 EREVGRLCQ-RSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL 2447
Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
M + + ++L++H + + ++++ +SI+ + LL GHP
Sbjct: 2448 LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHP 2507
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
S I + + +++ +L+ +E ++ L+Q L V ++E W+ KE S
Sbjct: 2508 FSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE 2567
Query: 430 ELGQDFEHVSVL--QEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG 487
L + L + K E+ E AG +++A+ L + GH A +
Sbjct: 2568 GLWDPLAPMEPLLWKHKMLEWDLEV-QAG--KISALEATARGLHQGGHPEAQSALGRCQA 2624
Query: 488 LNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSAS 547
+ L GTR L R+L F D++E+ + EK L E +
Sbjct: 2625 MLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK-----NLVALEEGLLDTA 2679
Query: 548 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEH--AEAIASREQEVLQGWKELLS 605
+ L+ ++ L + + Q QE + + + G H +EAI R +E+ W EL
Sbjct: 2680 MLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQD 2739
Query: 606 ACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGA 643
+ + +ALR + +L +W++ I ++ A
Sbjct: 2740 NSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRA 2777
Score = 130 bits (326), Expect = 5e-30
Identities = 147/636 (23%), Positives = 268/636 (42%), Gaps = 25/636 (3%)
Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 69
+D + + +H+ E+ + +E +ERE +L Q PE A +R + E+ + W
Sbjct: 2359 KDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWW 2418
Query: 70 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 129
+L S Q + L +A +L EL + +Q+ L++ Q
Sbjct: 2419 QLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQ 2478
Query: 130 SMESQVEEW------YREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183
+++++ W R G+ Q TA P ++++ + + L L QE
Sbjct: 2479 ECKAELDSWTDSISLARSTGQ-QLLTAGHPFSSDIRQVLA----GLEQELSSLEGAWQEH 2533
Query: 184 RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
+ L + EL ++ W+ + + L ++ + K++ L +++
Sbjct: 2534 QLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQ 2593
Query: 244 GPRLEEVLERAGALASLRSPEAE-AVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQY 302
++ + A L PEA+ A+ R L A R+A RR + L+ Q++ +
Sbjct: 2594 AGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAF 2652
Query: 303 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLK-KHLQLEQGVENYEESIAQLSRQCR 361
D EV AWL E+ L+ + E QL K ++ Q E +++ +L R+ +
Sbjct: 2653 LQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQ--ELQREGQ 2710
Query: 362 ALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAE 421
LL+ GHP SE I R ++ L+ L++ +++ L++ +L R + ELE+W+
Sbjct: 2711 RLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
Query: 422 KEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481
EV +P +GQ V L E + R+ A + Q + GH A +
Sbjct: 2771 IEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQ-AQAFVREGHCLAQDV 2829
Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541
E L + + L E + R L A L KFF DA E ++EK LP L +
Sbjct: 2830 EEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEK---LP-LAAAQD 2885
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEG--AAQLRTVYAGEH-AEAIASREQEVLQ 598
S S++ R L+ +L+ +S L + V AG A +A+R Q++ +
Sbjct: 2886 YGQSLSAV-RHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEK 2944
Query: 599 GWKELLSACEDARLHVSSTADALRFHSQVRDLLSWM 634
L + RL + +A +F +++ + SW+
Sbjct: 2945 AMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWL 2980
Score = 125 bits (314), Expect = 1e-28
Identities = 142/647 (21%), Positives = 264/647 (40%), Gaps = 31/647 (4%)
Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIR 65
D ED + +H+ F L+ E + G++L+Q + A +VR++L I+
Sbjct: 1199 DNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQ 1258
Query: 66 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 125
W L+ ++ + RQL + + + Q AEL + + + + +P G + L
Sbjct: 1259 AQWTRLQGRSEQRRRQLLASLQLQEWKQDVAEL-MQWMEEKGLMAAHEPSGARRNILQTL 1317
Query: 126 KKLQSMESQVEEWYREVGEL-QAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERR 184
K+ ++ ES++ R V L Q L P +E + R + + L + ER
Sbjct: 1318 KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERG 1377
Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244
L + + Q+ L D +++ +E G L++ Q+ K++Q L E +
Sbjct: 1378 DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLA 1437
Query: 245 PRLEEVLERAGALASLRS--PEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQY 302
++ + A +A+ + E + R LE LQ A R L A+ ++ Q+
Sbjct: 1438 AKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLA-------IRGLQLQASVELHQF 1490
Query: 303 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRA 362
+W+ E + L +KH +L+ V+ ++ + ++ R+
Sbjct: 1491 CHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRS 1550
Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422
L GHP ++ I + +++ + L+ E R L+Q Q VSELE W+ EK
Sbjct: 1551 LAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEK 1610
Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA--- 479
+ S + G+D L K A +E LA ++EL + T
Sbjct: 1611 RPLVSSRDYGRDEAATLRLINKH--------QALQEELAIYWSSMEELDQTAQTLTGPEV 1662
Query: 480 --TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537
++ L E L EL TR + L + LH+F +A +LQG + +++
Sbjct: 1663 PEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGE 1722
Query: 538 TPPEPRPSASSMQRTLRAFEHDLQL---LVSQVRQLQEGAAQLRTVYAGEHAEAIASREQ 594
+ E A + F+H +++ V+ R L E + R AG + R+Q
Sbjct: 1723 SLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLE-RGHSAG---PMVRQRQQ 1778
Query: 595 EVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQI 641
++ W EL + + T LR H + ++L+ + A+ +
Sbjct: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL 1825
Score = 123 bits (309), Expect = 5e-28
Identities = 133/597 (22%), Positives = 248/597 (41%), Gaps = 40/597 (6%)
Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
L+++ F+ LA K ++ +QL Q P + ++++ E+ Q W +LE+ + KA
Sbjct: 899 LKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKA 958
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNS-------------QLK 126
QL + + +Q +L + QL+ + PG T ++ ++
Sbjct: 959 VQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVH 1018
Query: 127 KLQSMESQVEE-WYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRR 185
LQS+ +VEE Y E LQ Q L + L+ + Q V +R R E Q R+
Sbjct: 1019 FLQSVVVKVEEPGYAESQPLQGQVETL------QGLLKQVQEQVAQRARRQAET-QARQS 1071
Query: 186 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 245
L S++L L W + E + + Q+ ++++Q L EI
Sbjct: 1072 FLQESQQL----------LLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQE 1121
Query: 246 RLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFD 305
RL+++ ++ +A+L P+++ V L L L+ E+RQQ L +++++ +
Sbjct: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGRE 1181
Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE 365
V A + + ++ G+D + L LL++H + + + L L++
Sbjct: 1182 VDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQ 1241
Query: 366 MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425
HP + + + + + L+ E+RR L L + + V+EL W+ EK ++
Sbjct: 1242 SQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLM 1301
Query: 426 AGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIE---CGHTAAATMA 482
A G + L K E A +A R + A+ Q+ EL+ CG T
Sbjct: 1302 AAHEPSGARRNILQTL--KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRL 1359
Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEP 542
+ GL W L M R L + + + ++ + Q+E+ L T +
Sbjct: 1360 Q---GLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDL 1416
Query: 543 RPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599
R S+ +Q+ + E + + L +++ L A + A R E+LQG
Sbjct: 1417 R-SSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQG 1472
Score = 122 bits (307), Expect = 8e-28
Identities = 145/688 (21%), Positives = 264/688 (38%), Gaps = 85/688 (12%)
Query: 46 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM 105
L QE+ A V ++ E+ W L Q + +Q+ + L+Q +L +
Sbjct: 458 LRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEEL 517
Query: 106 ESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLE-PASKELVGE 164
+ + G LA V L++ +E+QV V L QTA L S E++
Sbjct: 518 QEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQA 577
Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224
+ + + L+ ++ RR LL + + + + ++E AW++E G L
Sbjct: 578 KARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLS 637
Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284
+ ++K++ L E+ H +++ R L++ R P E +Q W L+
Sbjct: 638 QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQT 697
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344
R L A V QY+ D AE +WL E+ + G+D+ + LL++H++LE+
Sbjct: 698 RVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLER 757
Query: 345 GVENYEESIAQLSRQCRALLEMG---------------------------HP-------- 369
+ + + +L Q RA HP
Sbjct: 758 VLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKM 817
Query: 370 ----------DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419
D I + Q + + Y +L+ L + RR LE+ L+ EL+ W+
Sbjct: 818 ALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL 877
Query: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479
++ V+ + + + V+Q K+ F + + G+ A V+ ++L + +
Sbjct: 878 EKQTVLL--QRVQPQADTLEVMQLKYENFLTALAV-GKGLWAEVSSSAEQLRQRYPGNST 934
Query: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539
+ ++ L++ W +L L +A LA S E+ F + Q Q+ + +L L P
Sbjct: 935 QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEAL-QP 993
Query: 540 PEPRPSASSMQ------RTLRAFEHDLQLLVSQV----------------------RQLQ 571
+ ++Q L H LQ +V +V +Q+Q
Sbjct: 994 GSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQ 1053
Query: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA---CEDARLHVSSTADALRFHSQVR 628
E AQ A A +E + L W E + A ++ + V+S LR H +
Sbjct: 1054 EQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLL 1113
Query: 629 DLLSWMDGIASQIGAADKPR----CPSS 652
+ + Q+ A +P CP S
Sbjct: 1114 EEIHLWQERLQQLDAQSQPMAALDCPDS 1141
Score = 111 bits (278), Expect = 2e-24
Identities = 124/582 (21%), Positives = 245/582 (42%), Gaps = 29/582 (4%)
Query: 41 REGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDK 100
REG L Q+ E A + ++ +R+ E + +A++ L AD+ A + +
Sbjct: 2820 REGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADE---EMAWVQE 2876
Query: 101 KLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA--S 158
KL +Q D G L+ V ++ Q++ES++ + + + T ++ +
Sbjct: 2877 KLPLAAAQ----DYGQSLSAVRHLQEQHQNLESEMSS-HEALTRVVLGTGYKLVQAGHFA 2931
Query: 159 KELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTE 218
V R + + + L RR LL ++E Q +L + +W+ ER + +
Sbjct: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSA 278
G+ +A Q +++ + +R+++A PR+E + + A L S ++PE+ V L+ ++ A
Sbjct: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREA 3051
Query: 279 WAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKK 338
A L AE R L Q+ Q + ++AWL + S+D G+D + L +K
Sbjct: 3052 HAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEK 3111
Query: 339 HLQLEQGVENYEESIAQLSRQCRALLEMGHPDS-EQISRRQSQVDRLYVALKELGEERRV 397
+ V++ ++ R+ LE G P I ++S+++ + L + + R
Sbjct: 3112 FDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171
Query: 398 ALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGR 457
L + ++ + +EL+ + EK + + G V LQ++ E +
Sbjct: 3172 NLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEK 3231
Query: 458 ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517
E +A + L + A +A+ + EAWA L R Q LA + + H F
Sbjct: 3232 E-VARLQTEACRLGQLHPAAPGGLAK----VQEAWATLQAKAQERGQWLAQAAQGHAFLG 3286
Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFE---HDLQLLVSQVRQLQEGA 574
+EL +E++ L + E + ++ L E +++ Q + L++
Sbjct: 3287 RCQELLAWAQERQ----ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342
Query: 575 AQL------RTVYAGEHAEAIASREQEVLQGWKELLSACEDA 610
QL + E + + R QE+ + W C ++
Sbjct: 3343 QQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAES 3384
Score = 100 bits (250), Expect = 3e-21
Identities = 147/628 (23%), Positives = 265/628 (42%), Gaps = 37/628 (5%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
+HQA ELA +E++++ Q L E PE V+++L E + EL +T +
Sbjct: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---RD 1688
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEW 138
R+L + + ++ +L L + + + G D K + QVE
Sbjct: 1689 RELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMG 1748
Query: 139 YREVGELQAQTAALPLEP--ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ V + +L LE ++ +V +RQ + L E Q R L ++ +V
Sbjct: 1749 SQRVAACRLLAESL-LERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807
Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGA 256
DL + L VQE+ ++ L ++ ++ +QGL RE+ +L+E+LE AG
Sbjct: 1808 HRDLLEVLTQVQEKAT-SLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
Query: 257 LASL-RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 315
+ L P+A AV++ + + AWA L+ E+R+ L+ A + ++ V + +W
Sbjct: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
Query: 316 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYE---ESIAQLSRQCRALLEMGHPD-- 370
+ E+ ++ S L H L +E E + QL +Q ALL G P
Sbjct: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQ--ALLAAGTPTKE 1984
Query: 371 -SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
E++ Q Q D++Y ++ R+ EQQ L+ R+ LE +A +EV +
Sbjct: 1985 VQEELRALQDQRDQVYQTWAR--KQERLQAEQQEQLF--LRECGRLEEILAAQEVSLKTS 2040
Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489
LG E V L K F + A ++ AA+ + + L + + L
Sbjct: 2041 ALGSSVEEVEQLIRKHEVFL-KVLTAQDKKEAALRERLKTL------RRPRVRDRLPILL 2093
Query: 490 EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549
+ + EL +R L AS + F A + + I+ ++L P + R +
Sbjct: 2094 QRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL 2153
Query: 550 QRTLRAFEHDLQL---LVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA 606
+ +AFE ++Q +++ V + E AGE ++ R Q + + W++L A
Sbjct: 2154 LKH-QAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE----VSQRLQGLRKHWEDLRQA 2208
Query: 607 CEDARLHVSSTADALRFHSQVRDLLSWM 634
+ + L F +V +W+
Sbjct: 2209 MALRGQELEDRRNFLEFLQRVDLAEAWI 2236
Score = 98.6 bits (244), Expect = 2e-20
Identities = 144/651 (22%), Positives = 254/651 (39%), Gaps = 91/651 (13%)
Query: 61 LGEIRQCWAELE----STTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD--- 113
L E+ QCWA LE + +QA ++L + + + L + F K ES L+D +
Sbjct: 358 LAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQH---KAALRESFLKDAEQVL 414
Query: 114 -----PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPL----EPASKELVGE 164
P LATV + +++L +E+ + + G QA + + S V
Sbjct: 415 DQARAPPASLATVEAAVQRLGMLEAGI---LPQEGRFQALAEIADILRQEQYHSWADVAR 471
Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224
RQ V R RLL+ LQ +R+ + + + + +++ ++E A T G L
Sbjct: 472 RQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLA 531
Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR---RGLEQLQSAWAG 281
V + ++++ L ++ AHG + + ++ L S E ++ R L QLQ +
Sbjct: 532 EVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVA 591
Query: 282 LREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341
L A R+ +L+ Q ++ + E EAWL E + + G+D L+KH
Sbjct: 592 LVRA---RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKA 648
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401
LE V ++ L R+ R L P R V + L+ R L+
Sbjct: 649 LEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQT 708
Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD--------FEHVSVLQEKFSEFASE-- 451
+ Q +E W+ E+ GQD HV L+ FA+E
Sbjct: 709 ALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVR-LERVLRAFAAELR 767
Query: 452 ------TGMAGRERLAAVNQMV----DELIECGHTAAA---------------------- 479
+ R L VN + + L G + A
Sbjct: 768 RLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDF 827
Query: 480 ---TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 536
T+ + +D L++ + L L R L + L F S ELQ +E++ L R+
Sbjct: 828 DPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRV 887
Query: 537 TTPPEPRPSASSMQRTLRAFEHDLQLLV---SQVRQLQEGAAQLRTVYAGEHAEAIASRE 593
+P A +++ +E+ L L ++ A QLR Y G + I ++
Sbjct: 888 ------QPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ-IQRQQ 940
Query: 594 QEVLQGWKELLSACEDARLHVSSTADALRF-------HSQVRDLLSWMDGI 637
+E+ Q W +L + + + ++ + + F Q+RD+L ++ +
Sbjct: 941 EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEAL 991
Score = 98.2 bits (243), Expect = 2e-20
Identities = 101/450 (22%), Positives = 191/450 (42%), Gaps = 8/450 (1%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
R +A +L +E++++ L K + V +L +R+ AEL +A+
Sbjct: 3005 RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGH 3064
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
L E + QL + LD L + + D G DL V +K + +V+ +
Sbjct: 3065 GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQ 3124
Query: 141 -EVGELQAQTAALPL-EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH 198
+V L+ L P + +++ + RL + ++ R L A+ E+H
Sbjct: 3125 AKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184
Query: 199 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258
+ +QE+ L + G+ L +V+ ++++ L RE++A + + A L
Sbjct: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLG 3244
Query: 259 SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQEL 318
L A GL ++Q AWA L+ A+ R Q L A Q + E+ AW E++
Sbjct: 3245 QLHP----AAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
Query: 319 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQ 378
L SE+ +D QLL +H +L Q + L ++ + L++ H S +++
Sbjct: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
Query: 379 SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 438
+++ L+E R + + L +L +++ + E W+A E + P+ G V
Sbjct: 3361 QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV 3420
Query: 439 SVLQEKFSEFASETGMAGRERLAAVNQMVD 468
+L + + E +A +E A Q +
Sbjct: 3421 ELLLHRHQDL--EKLLAAQEEKFAQMQKTE 3448
Score = 86.7 bits (213), Expect = 7e-17
Identities = 134/655 (20%), Positives = 267/655 (40%), Gaps = 46/655 (7%)
Query: 21 RHQAFMAEL-AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
+H+ F+ L AQ+K+ E RE + ++ VR +L + Q ++ +++
Sbjct: 2055 KHEVFLKVLTAQDKK--EAALRERLKTLRRP-----RVRDRLPILLQRRMRVKELAESRG 2107
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
L + Q+ + + + QL++ P GDL L K Q+ E++V+
Sbjct: 2108 HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHE 2167
Query: 140 REVGELQAQTAALPLEP------ASKELVGERQNAVGERLVRLL--EPLQERRRLLLASK 191
+ + + AL + S+ L G R++ R L + L++RR L
Sbjct: 2168 EVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL---- 2223
Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ---AVQQHIKKNQGLRREIQAHGPRLE 248
+ +D AW+QE+ + G L+ +++ +++ +G +
Sbjct: 2224 ---EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
Query: 249 EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 308
+ + + L + E + + + QL + WA R QQ L+ A ++ ++
Sbjct: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
Query: 309 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 368
V + E+E L+ + D GKD +S +LL+KH +LE+ V + + L R+ L +
Sbjct: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
Query: 369 PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA-- 426
+ + RQ +V + L+ ++RR AL+ + +L + EL ++ + + A
Sbjct: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL--LVSAQRLRAQM 2458
Query: 427 -GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485
SP E +L+E E +E + + ++ +L+ GH ++ + +
Sbjct: 2459 DTSPAPRSPVEARRMLEE-HQECKAELD-SWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516
Query: 486 DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR--LTTPPEPR 543
GL + + L L + EL F S +++ + K L L P P
Sbjct: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPM 2576
Query: 544 PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIAS--REQEVLQGWK 601
+ L E DL++ ++ L+ A R ++ G H EA ++ R Q +L +
Sbjct: 2577 EPLLWKHKML---EWDLEVQAGKISALE---ATARGLHQGGHPEAQSALGRCQAMLLRKE 2630
Query: 602 ELLSACEDARLHVSSTADALRFHSQVRDLLSWM---DGIASQIGAADKPRCPSSL 653
L R + F +++ +W+ + +A + G D P+ L
Sbjct: 2631 ALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685
Score = 59.3 bits (142), Expect = 1e-08
Identities = 121/605 (20%), Positives = 233/605 (38%), Gaps = 77/605 (12%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL-GEIRQCWAELESTTQAKAR 80
H A ++ LAQ L+ +++Q K A +++ L +R A LE T Q
Sbjct: 550 HGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-- 607
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+ +++ E + L ++ + G DL+ + L+K +++E++V
Sbjct: 608 ---------EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQA 658
Query: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199
+L + L P ++ GER AV L + R L + + Q D
Sbjct: 659 VCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFAD 718
Query: 200 LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP---RLEEVLERAGA 256
+ +W++ER + G A + ++++ L R ++A RLEE A A
Sbjct: 719 AAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASA 778
Query: 257 LASL------RSPEAEAVR------------------------------------RGLEQ 274
ASL SP E++R + +
Sbjct: 779 RASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDH 838
Query: 275 LQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 334
L + LR A+ R+ L+ A + + E++ WL +Q +L+ D +Q
Sbjct: 839 LSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQ 898
Query: 335 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394
L K+ + + A++S L + +S QI R+Q ++ + + L+ L E
Sbjct: 899 L--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE 956
Query: 395 RRVALEQQYWLYQLSRQVSELEHWIAE--KEVVAGSPELGQDFEHVSVLQEKFSEFASET 452
+ V L + ++ + + + ++ A P +D H L +K +
Sbjct: 957 KAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT------ 1010
Query: 453 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 512
+ R+ + +V ++ E G+ + + + L ++ E + RA+ A ++
Sbjct: 1011 -LVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQAR 1069
Query: 513 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQE 572
F ++++L E + +L E +S QR LR EH Q L+ ++ QE
Sbjct: 1070 QSFLQESQQLLLWAESVQAQL----RSKEVSVDVASAQRLLR--EH--QDLLEEIHLWQE 1121
Query: 573 GAAQL 577
QL
Sbjct: 1122 RLQQL 1126
Score = 58.2 bits (139), Expect = 3e-08
Identities = 106/492 (21%), Positives = 192/492 (39%), Gaps = 46/492 (9%)
Query: 169 VGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228
V RL ++L LQE L + Q+ DL L W+ E+ + + L A++Q
Sbjct: 255 VQRRLTKILLQLQETE---LLQTQYEQLVADL---LRWIAEKQMQLEARDFPDSLPAMRQ 308
Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR--------GLEQLQSAWA 280
+ R Q PRL++ L L++ RR GL +L WA
Sbjct: 309 LLAAFTIFRT--QEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWA 366
Query: 281 GLREAAERRQQVLDAAF--------QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQST 332
GL A R Q L ++ A E++L + E ++ D+ + ++
Sbjct: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVL---DQARAPPAS 423
Query: 333 LQLLKKHLQ----LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVD-RLYVA 387
L ++ +Q LE G+ E L+ L + + ++RRQ +V R
Sbjct: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
Query: 388 LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSE 447
L+ L +R+ + Q L L ++V H + E + A S GQ V L ++
Sbjct: 484 LQHLQGQRKQVADMQAVL-SLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDL 542
Query: 448 FASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLA 507
++ G ++ + Q EL T+ + L + L+ L+ R LL
Sbjct: 543 LEAQVSAHG-AHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLE 601
Query: 508 ASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ--RTLRAFEHDLQ-LLV 564
+ + +F + E + ++E +R+ + A ++Q + L A H Q + V
Sbjct: 602 QTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCV 661
Query: 565 SQVRQLQEGAAQLRTVY--AGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622
VR+ ++ +A+ GE AEA+ GW+ L + + + L+
Sbjct: 662 DLVRRGRDLSARRPPTQPDPGERAEAVQG-------GWQLLQTRVVGRGARLQTALLVLQ 714
Query: 623 FHSQVRDLLSWM 634
+ + + SW+
Sbjct: 715 YFADAAEAASWL 726
Score = 52.0 bits (123), Expect = 2e-06
Identities = 133/676 (19%), Positives = 235/676 (34%), Gaps = 85/676 (12%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+H+A AE+ +++ + R G+ L +P ++ ++ W L++ +
Sbjct: 645 KHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGA 704
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+L A Q AE L S L+ G D A + L++ +E + +
Sbjct: 705 RLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAA 764
Query: 141 EVGELQAQ-------------------------------------------TAALPLEP- 156
E+ L+ Q ALP EP
Sbjct: 765 ELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPD 824
Query: 157 --ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLA 214
+ + Q+ + + L Q RR L + L + W++++ L
Sbjct: 825 PDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL 884
Query: 215 MQTE-RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLE 273
+ + + + L+ +Q K + + EV A L + ++R E
Sbjct: 885 QRVQPQADTLEVMQ---LKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQE 941
Query: 274 QLQSAWAGLREAAERRQQVLDAAFQVEQYYF--DVAEVEAWLGEQELLMMSEDKGKDEQS 331
+L W L A +R++ + A VE F + + L + L + + G E +
Sbjct: 942 ELSQRWGQLE--ALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDT 999
Query: 332 --TLQLL-KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVAL 388
LQL KK L LE+ V + + ++ E G+ +S+ + Q QV+ L L
Sbjct: 1000 CHALQLAQKKTLVLERRVHFLQSVVVKVE-------EPGYAESQPL---QGQVETLQGLL 1049
Query: 389 KELGEE-----RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQE 443
K++ E+ RR A Q + Q +L W + S E+ D L
Sbjct: 1050 KQVQEQVAQRARRQAETQARQSFLQESQ--QLLLWAESVQAQLRSKEVSVDVASAQRLLR 1107
Query: 444 KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRA 503
+ + E + +ERL ++ + + + L + EL L R
Sbjct: 1108 EHQDLLEEIHL-WQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166
Query: 504 QLLAASRELHKFFSDARELQGQIE--EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQ 561
Q L EL KF RE+ G + L E A S+ + R F L
Sbjct: 1167 QWLQEGLELQKF---GREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLS 1223
Query: 562 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQGWKELLSACEDARLHVSSTAD 619
L + L+ +L +H A RE Q + W L E R + ++
Sbjct: 1224 TLGPRAEALRAHGEKL---VQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQ 1280
Query: 620 ALRFHSQVRDLLSWMD 635
+ V +L+ WM+
Sbjct: 1281 LQEWKQDVAELMQWME 1296
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 203 bits (517), Expect = 4e-52
Identities = 171/638 (26%), Positives = 290/638 (45%), Gaps = 47/638 (7%)
Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
M A D +D L + +HQAF AEL+ N+ ++ +E+ GQ+L+ V +
Sbjct: 593 MKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAAR 652
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
+ E+ W +L T+ K +L EA++ Q ++ +++ L +E L D G DL
Sbjct: 653 MNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN 712
Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK---ELVGERQNAVGERLVRLL 177
V + KK +E+ V + + Q A + A E + ++Q A+ R L
Sbjct: 713 VQNLQKKHALLEADVAAHQDRIDGITIQ--ARQFQDAGHFDAENIKKKQEALVARYEALK 770
Query: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237
EP+ R++ L S L Q+ D++DE W++E+ P+A T RG L VQ +KK+Q L+
Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830
Query: 238 REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297
EI H PR++ V ++ A+ AE V+ L +L W L+ A +R+Q L+ +
Sbjct: 831 AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890
Query: 298 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357
Q +QY+ D E E+W+ E+E ++ S D GKDE S LLKKH L + Y SI L
Sbjct: 891 QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
Query: 358 RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLYQLSR----- 410
Q ++ + P ++ + L +AL + E+ R V +++ L L+
Sbjct: 951 EQAQSCRQQVAPTDDETGK------ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDW 1004
Query: 411 ---QVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467
+V++ + ++ V P Q ++L+E+ S +A + +
Sbjct: 1005 WKVEVNDRQGFVPAAYVKKLDP--AQSASRENLLEEQGS-------------IALRQEQI 1049
Query: 468 DELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527
D A + K + E + LLEL R +L S + F +A ELQ I
Sbjct: 1050 DNQTRITKEAGSVSLRMKQ-VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWIN 1108
Query: 528 EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAE 587
EK L + +Q+ F+ DL+ S+++ + + A L + G AE
Sbjct: 1109 EKEAALTSEEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES--EGLMAE 1165
Query: 588 AIASREQEVLQGW-------KELLSACEDARLHVSSTA 618
+ + +Q+ + G + S + ARL V + A
Sbjct: 1166 EVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVA 1203
Score = 189 bits (479), Expect = 9e-48
Identities = 136/516 (26%), Positives = 239/516 (46%), Gaps = 6/516 (1%)
Query: 4 ARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS---VRKK 60
A D + +D + + +HQAF AEL N + + + G L+ E+ A S V+ +
Sbjct: 1574 ASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLI-ERGACAGSEDAVKAR 1632
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
L + W L + K+++L EA+K + D L +E+ L D G DLA+
Sbjct: 1633 LAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLAS 1692
Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA-SKELVGERQNAVGERLVRLLEP 179
VN+ LKK Q +E+ + + +L +Q +L A V ++++ + R ++
Sbjct: 1693 VNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSM 1752
Query: 180 LQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE 239
RR L S LHQ D+DDE +W++E+ L + G L VQ KK++ L E
Sbjct: 1753 AASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAE 1812
Query: 240 IQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV 299
+ AH P ++ VL+ L+ + E +++ L Q W L++ A R Q L+ + +
Sbjct: 1813 LAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEY 1872
Query: 300 EQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ 359
+Q+ +V E EAW+ E+ L+ SED G + LLKKH E +++ + +
Sbjct: 1873 QQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTN 1932
Query: 360 CRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419
+ L++ + E IS + ++ L++ +R+ L++ Q + + +E WI
Sbjct: 1933 GQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWI 1992
Query: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479
EKE + + G+D V L K F + +E +A + + D+L+ H +
Sbjct: 1993 GEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSK 2052
Query: 480 TMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHK 514
+ L + W++LL R +LL A K
Sbjct: 2053 AIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRK 2088
Score = 157 bits (398), Expect = 2e-38
Identities = 135/560 (24%), Positives = 251/560 (44%), Gaps = 10/560 (1%)
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
RQ E S Q Q AE +K + + Q+ + D + +L+K Q+ E++V+
Sbjct: 37 RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANS 96
Query: 140 REVGELQAQTAALPLEPA--SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVA 197
+ +L +T L + + E + R + + LLE ++E+ LL +++L Q
Sbjct: 97 GAIVKLD-ETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYL 155
Query: 198 HDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 257
+ +D + W+ ++ + E G L+ V+ KK + + ++ AH R+ EV + A L
Sbjct: 156 RECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKL 215
Query: 258 ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQE 317
+ PE E ++ +++ +AW L+ A +RQ L A +V+++ DV E +W+ E+E
Sbjct: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKE 275
Query: 318 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP-DSEQISR 376
LM S+D G+D S LL+KH LE+ + E+ + L + L+ HP + QI
Sbjct: 276 QLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADR-LQQSHPLSATQIQV 334
Query: 377 RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFE 436
++ ++ + ++ L ER L Y L + +L W+ E + + + EL D
Sbjct: 335 KREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVA 394
Query: 437 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELL 496
L ++ E E A + + ++ L+ GH A+ + E L+E A LL
Sbjct: 395 GAEALLDRHQEHKGEID-AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALL 453
Query: 497 ELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAF 556
EL R Q +L F+ D ++ + ++ L + S ++ + F
Sbjct: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN-EDLGDSLDSVEALLKKHEDF 512
Query: 557 EHDLQLLVSQVRQLQEGAAQLRTVYAGEHA-EAIASREQEVLQGWKELLSACEDARLHVS 615
E L ++ L E A +L + +A E +A+R +L L R ++
Sbjct: 513 EKSLSAQEEKITALDEFATKL--IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLA 570
Query: 616 STADALRFHSQVRDLLSWMD 635
+ +F +L SW++
Sbjct: 571 DSFHLQQFFRDSDELKSWVN 590
Score = 154 bits (389), Expect = 3e-37
Identities = 142/617 (23%), Positives = 255/617 (41%), Gaps = 20/617 (3%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+ + F ++A ++E + ++ + +L+QE+ ++ K E+ W L+ +
Sbjct: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+LF A++ + + E + E + D G DLA+V + L+K + +E +
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199
+V L A+ L P S + ++ + ++ ER L S L + D
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 200 LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS 259
D +WV E L E + + + + ++Q + EI AH + E AL +
Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
Query: 260 LRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELL 319
++ VR L L A L E E R+Q + ++ +Y D +V+ W+ +QE
Sbjct: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
Query: 320 MMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 379
+++ED G S LLKKH E+ + EE I L L++ H E ++ R+
Sbjct: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549
Query: 380 QVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 439
+ AL E RR L + L Q R EL+ W+ EK A + E +D ++
Sbjct: 550 ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA-TDEAYKDPSNLQ 608
Query: 440 VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELM 499
+K F +E A + R+ A+ + +LI+ H A +A + + W +LLE
Sbjct: 609 GKVQKHQAFEAELS-ANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667
Query: 500 GTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR------LTTPPEPRPSASSMQRTL 553
+ L + + +F + +++ + E L LT + + ++ +
Sbjct: 668 ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
Query: 554 RAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLH 613
A + + + Q RQ Q+ AG ++QE L E L AR
Sbjct: 728 AAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVARYEALKEPMVAR-- 776
Query: 614 VSSTADALRFHSQVRDL 630
AD+LR RD+
Sbjct: 777 KQKLADSLRLQQLFRDV 793
Score = 153 bits (386), Expect = 6e-37
Identities = 132/648 (20%), Positives = 286/648 (44%), Gaps = 11/648 (1%)
Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
LMA D D + +H+ +LA ++ ++ + E +L Q P A ++ K
Sbjct: 277 LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
E+ W ++ + + +L ++ + + + F +L + M++ + + D+A
Sbjct: 337 EELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGA 396
Query: 122 NSQLKKLQSMESQV---EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178
+ L + Q + ++ E+ ++ E + A L + + V E+ + E LLE
Sbjct: 397 EALLDRHQEHKGEIDAHEDSFKSADE--SGQALLAAGHYASDEVREKLTVLSEERAALLE 454
Query: 179 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 238
+ RR+ +L D + W+ ++ + + G+ L +V+ +KK++ +
Sbjct: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514
Query: 239 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 298
+ A ++ + E A L E V + L S L E A RR+ L +F
Sbjct: 515 SLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFH 574
Query: 299 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 358
++Q++ D E+++W+ E ++ +++ KD + ++KH E + + I L +
Sbjct: 575 LQQFFRDSDELKSWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEK 633
Query: 359 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHW 418
+ L+++ H ++++ R ++V L+ L E E + + L + Q +R V ++E W
Sbjct: 634 AGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELW 693
Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
+ E E S + G+D +V LQ+K + ++ A ++R+ + + + GH A
Sbjct: 694 LYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA-AHQDRIDGITIQARQFQDAGHFDA 752
Query: 479 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTT 538
+ + ++ L + L E M R Q LA S L + F D + + I EK + T
Sbjct: 753 ENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK-EPIAASTN 811
Query: 539 PPEPRPSASSMQRTLRAFEHDLQLLVSQVRQL-QEGAAQLRTVYAGEHAEAIASREQEVL 597
+ ++ + +A + ++ +++ + Q+G A + + AE + ++ E+
Sbjct: 812 RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFA--AEDVKAKLHELN 869
Query: 598 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
Q W+ L + R + + A ++ + + SWM +G+ D
Sbjct: 870 QKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTD 917
Score = 150 bits (380), Expect = 3e-36
Identities = 130/614 (21%), Positives = 272/614 (44%), Gaps = 19/614 (3%)
Query: 42 EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKK 101
E ++ M EK + ++ E++Q W + + + + L + F + K
Sbjct: 1081 EKRKGMLEKSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKD 1139
Query: 102 LLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKE 160
L ES+L+D++ DL + +++Q+++ Q E ++TA+ P + A
Sbjct: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTAS-PWKSARLM 1198
Query: 161 L----VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQ 216
+ + ER L + +ER +LL ++ E+ + D D+ W++E+
Sbjct: 1199 VHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNT 1258
Query: 217 TERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQ 276
G+ L +VQ +K++G R++ A G ++ + E A L AE ++ +L
Sbjct: 1259 DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
Query: 277 SAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLL 336
AW+ L + A++R+ L + ++++ D ++ +W+ L+ S++ KD LL
Sbjct: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396
++H + ++ + + + LL GH S +I ++ +D+ L++ +RR
Sbjct: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438
Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456
+ L+Q L R + E+W+A +E + + G + V L +K +F +
Sbjct: 1439 MMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ- 1497
Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 516
E++AA+ D+LI GH A ++ ++ + + W L M + L S+ L +F
Sbjct: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
Query: 517 SDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ---RTLRAFEHDLQLLVSQVRQLQEG 573
D E++ I EK + T E +++Q + +AFE +L ++R + +
Sbjct: 1558 RDVDEIEAWISEKLQ-----TASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDM 1612
Query: 574 AAQL--RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631
L R AG +A+ +R + W+ L+ + + F++ ++D
Sbjct: 1613 GNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFD 1671
Query: 632 SWMDGIASQIGAAD 645
W+ + + + + D
Sbjct: 1672 FWLSEVEALLASED 1685
Score = 144 bits (364), Expect = 2e-34
Identities = 107/382 (28%), Positives = 184/382 (48%), Gaps = 10/382 (2%)
Query: 265 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 324
AE ++ +Q+ + +E + R+Q L+ +++ + + D E+E W+ +++L + S++
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDE 70
Query: 325 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 384
KD + L+KH E V+ +I +L ++ GH SE I R ++ R
Sbjct: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 385 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 444
+ L E E+ + L Q L Q R+ ++ WI +KE + S ELGQD EHV VLQ+K
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 445 FSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQ 504
F EF ++ A ER+ VNQ +LI+ H + +D +N AW L L R
Sbjct: 191 FEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 505 LLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQ 561
L + E+ +F D E I+EK +L + +S+Q LR E DL
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKE----QLMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 562 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 621
L +V+ L A +L+ + A I + +E++ W+++ + + ++ +
Sbjct: 306 ALEDKVKALCAEADRLQQSHP-LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
Query: 622 RFHSQVRDLLSWMDGIASQIGA 643
RF + RDL SW+ + + I A
Sbjct: 365 RFLADFRDLTSWVTEMKALINA 386
Score = 120 bits (301), Expect = 4e-27
Identities = 126/651 (19%), Positives = 271/651 (41%), Gaps = 31/651 (4%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+H+ F +LA + + + ++L+Q PE A +++K E+ Q W+ L +
Sbjct: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+L ++ + + F +L + + + + D+ + L++ Q ++++
Sbjct: 1334 KLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEID---A 1390
Query: 141 EVGELQA-----QTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQ 195
G QA Q AS E + ++ + + + L + +RR +L EL
Sbjct: 1391 RAGTFQAFEQFGQQLLAHGHYASPE-IKQKLDILDQERADLEKAWVQRRMMLDQCLELQL 1449
Query: 196 VAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAG 255
D + W+ R ++G+ L +V+ IKK++ + I ++ + A
Sbjct: 1450 FHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFAD 1509
Query: 256 ALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 315
L + + ++ W L+ ++ L + ++Q+ DV E+EAW+ E
Sbjct: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE 1569
Query: 316 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG--HPDSEQ 373
+L S++ KD + +KH E + + I + +L+E G +
Sbjct: 1570 -KLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA 1628
Query: 374 ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQ 433
+ R + + + L + E+ L++ + + + + W++E E + S + G+
Sbjct: 1629 VKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGK 1688
Query: 434 DFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWA 493
D V+ L +K ++ A +RL +N D L+ + + + +D +N +
Sbjct: 1689 DLASVNNLLKKHQLLEADIS-AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQ 1747
Query: 494 ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR------LTTPPEPRPSAS 547
++ + +R L S LH+FF D + + I+EK+ + LT R
Sbjct: 1748 KIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHK 1807
Query: 548 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKEL--LS 605
++ L A E +Q ++ ++L + T+ E I R + ++ WKEL L+
Sbjct: 1808 RLEAELAAHEPAIQGVLDTGKKLSDD----NTI----GKEEIQQRLAQFVEHWKELKQLA 1859
Query: 606 ACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGL 656
A RL S + +F + V + +W++ + + + D +++ GL
Sbjct: 1860 AARGQRLEES--LEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGL 1908
Score = 119 bits (299), Expect = 7e-27
Identities = 92/371 (24%), Positives = 168/371 (45%), Gaps = 2/371 (0%)
Query: 160 ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER 219
E + ER+ V +R R E RR+ L S D ++ W+QE+L +A E
Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA-SDEN 71
Query: 220 GNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW 279
+Q ++K+Q E+QA+ + ++ E + S +E +R L +L W
Sbjct: 72 YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
Query: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339
L E + L A ++ QY + +V W+ ++E ++ SE+ G+D + L KK
Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
Query: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVAL 399
+ + + +EE + ++++ L++ HP+ E I +Q +V+ + LK L +R+ L
Sbjct: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
Query: 400 EQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 459
+ + +R V E WI EKE + S + G+D V L K + A ++
Sbjct: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA-ALEDK 310
Query: 460 LAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDA 519
+ A+ D L + +A + ++ L W ++ L R L S L +F +D
Sbjct: 311 VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370
Query: 520 RELQGQIEEKR 530
R+L + E +
Sbjct: 371 RDLTSWVTEMK 381
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 203 bits (517), Expect = 4e-52
Identities = 171/638 (26%), Positives = 290/638 (45%), Gaps = 47/638 (7%)
Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
M A D +D L + +HQAF AEL+ N+ ++ +E+ GQ+L+ V +
Sbjct: 593 MKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAAR 652
Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
+ E+ W +L T+ K +L EA++ Q ++ +++ L +E L D G DL
Sbjct: 653 MNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN 712
Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK---ELVGERQNAVGERLVRLL 177
V + KK +E+ V + + Q A + A E + ++Q A+ R L
Sbjct: 713 VQNLQKKHALLEADVAAHQDRIDGITIQ--ARQFQDAGHFDAENIKKKQEALVARYEALK 770
Query: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237
EP+ R++ L S L Q+ D++DE W++E+ P+A T RG L VQ +KK+Q L+
Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830
Query: 238 REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297
EI H PR++ V ++ A+ AE V+ L +L W L+ A +R+Q L+ +
Sbjct: 831 AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890
Query: 298 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357
Q +QY+ D E E+W+ E+E ++ S D GKDE S LLKKH L + Y SI L
Sbjct: 891 QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
Query: 358 RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLYQLSR----- 410
Q ++ + P ++ + L +AL + E+ R V +++ L L+
Sbjct: 951 EQAQSCRQQVAPTDDETGK------ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDW 1004
Query: 411 ---QVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467
+V++ + ++ V P Q ++L+E+ S +A + +
Sbjct: 1005 WKVEVNDRQGFVPAAYVKKLDP--AQSASRENLLEEQGS-------------IALRQEQI 1049
Query: 468 DELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527
D A + K + E + LLEL R +L S + F +A ELQ I
Sbjct: 1050 DNQTRITKEAGSVSLRMKQ-VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWIN 1108
Query: 528 EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAE 587
EK L + +Q+ F+ DL+ S+++ + + A L + G AE
Sbjct: 1109 EKEAALTSEEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES--EGLMAE 1165
Query: 588 AIASREQEVLQGW-------KELLSACEDARLHVSSTA 618
+ + +Q+ + G + S + ARL V + A
Sbjct: 1166 EVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVA 1203
Score = 188 bits (478), Expect = 1e-47
Identities = 137/515 (26%), Positives = 238/515 (46%), Gaps = 6/515 (1%)
Query: 5 RDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS---VRKKL 61
+D T KL + +HQAF AEL N + + + G L+ E+ A S V+ +L
Sbjct: 1580 KDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLI-ERGACAGSEDAVKARL 1638
Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
+ W L + K+++L EA+K + D L +E+ L D G DLA+V
Sbjct: 1639 AALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASV 1698
Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA-SKELVGERQNAVGERLVRLLEPL 180
N+ LKK Q +E+ + + +L +Q +L A V ++++ + R ++
Sbjct: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMA 1758
Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
RR L S LHQ D+DDE +W++E+ L + G L VQ KK++ L E+
Sbjct: 1759 ASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL 1818
Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
AH P ++ VL+ L+ + E +++ L Q W L++ A R Q L+ + + +
Sbjct: 1819 AAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQ 1878
Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
Q+ +V E EAW+ E+ L+ SED G + LLKKH E +++ + +
Sbjct: 1879 QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNG 1938
Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
+ L++ + E IS + ++ L++ +R+ L++ Q + + +E WI
Sbjct: 1939 QDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIG 1998
Query: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480
EKE + + G+D V L K F + +E +A + + D+L+ H +
Sbjct: 1999 EKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKA 2058
Query: 481 MAEWKDGLNEAWAELLELMGTR-AQLLAASRELHK 514
+ L + W++LL R +LL A K
Sbjct: 2059 IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRK 2093
Score = 157 bits (398), Expect = 2e-38
Identities = 135/560 (24%), Positives = 251/560 (44%), Gaps = 10/560 (1%)
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
RQ E S Q Q AE +K + + Q+ + D + +L+K Q+ E++V+
Sbjct: 37 RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANS 96
Query: 140 REVGELQAQTAALPLEPA--SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVA 197
+ +L +T L + + E + R + + LLE ++E+ LL +++L Q
Sbjct: 97 GAIVKLD-ETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYL 155
Query: 198 HDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 257
+ +D + W+ ++ + E G L+ V+ KK + + ++ AH R+ EV + A L
Sbjct: 156 RECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKL 215
Query: 258 ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQE 317
+ PE E ++ +++ +AW L+ A +RQ L A +V+++ DV E +W+ E+E
Sbjct: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKE 275
Query: 318 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP-DSEQISR 376
LM S+D G+D S LL+KH LE+ + E+ + L + L+ HP + QI
Sbjct: 276 QLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADR-LQQSHPLSATQIQV 334
Query: 377 RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFE 436
++ ++ + ++ L ER L Y L + +L W+ E + + + EL D
Sbjct: 335 KREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVA 394
Query: 437 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELL 496
L ++ E E A + + ++ L+ GH A+ + E L+E A LL
Sbjct: 395 GAEALLDRHQEHKGEID-AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALL 453
Query: 497 ELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAF 556
EL R Q +L F+ D ++ + ++ L + S ++ + F
Sbjct: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN-EDLGDSLDSVEALLKKHEDF 512
Query: 557 EHDLQLLVSQVRQLQEGAAQLRTVYAGEHA-EAIASREQEVLQGWKELLSACEDARLHVS 615
E L ++ L E A +L + +A E +A+R +L L R ++
Sbjct: 513 EKSLSAQEEKITALDEFATKL--IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLA 570
Query: 616 STADALRFHSQVRDLLSWMD 635
+ +F +L SW++
Sbjct: 571 DSFHLQQFFRDSDELKSWVN 590
Score = 154 bits (389), Expect = 3e-37
Identities = 142/617 (23%), Positives = 255/617 (41%), Gaps = 20/617 (3%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+ + F ++A ++E + ++ + +L+QE+ ++ K E+ W L+ +
Sbjct: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+LF A++ + + E + E + D G DLA+V + L+K + +E +
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
Query: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199
+V L A+ L P S + ++ + ++ ER L S L + D
Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
Query: 200 LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS 259
D +WV E L E + + + + ++Q + EI AH + E AL +
Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
Query: 260 LRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELL 319
++ VR L L A L E E R+Q + ++ +Y D +V+ W+ +QE
Sbjct: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
Query: 320 MMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 379
+++ED G S LLKKH E+ + EE I L L++ H E ++ R+
Sbjct: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549
Query: 380 QVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 439
+ AL E RR L + L Q R EL+ W+ EK A + E +D ++
Sbjct: 550 ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA-TDEAYKDPSNLQ 608
Query: 440 VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELM 499
+K F +E A + R+ A+ + +LI+ H A +A + + W +LLE
Sbjct: 609 GKVQKHQAFEAELS-ANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667
Query: 500 GTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR------LTTPPEPRPSASSMQRTL 553
+ L + + +F + +++ + E L LT + + ++ +
Sbjct: 668 ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
Query: 554 RAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLH 613
A + + + Q RQ Q+ AG ++QE L E L AR
Sbjct: 728 AAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVARYEALKEPMVAR-- 776
Query: 614 VSSTADALRFHSQVRDL 630
AD+LR RD+
Sbjct: 777 KQKLADSLRLQQLFRDV 793
Score = 153 bits (386), Expect = 6e-37
Identities = 132/648 (20%), Positives = 286/648 (44%), Gaps = 11/648 (1%)
Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
LMA D D + +H+ +LA ++ ++ + E +L Q P A ++ K
Sbjct: 277 LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
E+ W ++ + + +L ++ + + + F +L + M++ + + D+A
Sbjct: 337 EELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGA 396
Query: 122 NSQLKKLQSMESQV---EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178
+ L + Q + ++ E+ ++ E + A L + + V E+ + E LLE
Sbjct: 397 EALLDRHQEHKGEIDAHEDSFKSADE--SGQALLAAGHYASDEVREKLTVLSEERAALLE 454
Query: 179 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 238
+ RR+ +L D + W+ ++ + + G+ L +V+ +KK++ +
Sbjct: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514
Query: 239 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 298
+ A ++ + E A L E V + L S L E A RR+ L +F
Sbjct: 515 SLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFH 574
Query: 299 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 358
++Q++ D E+++W+ E ++ +++ KD + ++KH E + + I L +
Sbjct: 575 LQQFFRDSDELKSWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEK 633
Query: 359 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHW 418
+ L+++ H ++++ R ++V L+ L E E + + L + Q +R V ++E W
Sbjct: 634 AGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELW 693
Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
+ E E S + G+D +V LQ+K + ++ A ++R+ + + + GH A
Sbjct: 694 LYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA-AHQDRIDGITIQARQFQDAGHFDA 752
Query: 479 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTT 538
+ + ++ L + L E M R Q LA S L + F D + + I EK + T
Sbjct: 753 ENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK-EPIAASTN 811
Query: 539 PPEPRPSASSMQRTLRAFEHDLQLLVSQVRQL-QEGAAQLRTVYAGEHAEAIASREQEVL 597
+ ++ + +A + ++ +++ + Q+G A + + AE + ++ E+
Sbjct: 812 RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFA--AEDVKAKLHELN 869
Query: 598 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
Q W+ L + R + + A ++ + + SWM +G+ D
Sbjct: 870 QKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTD 917
Score = 149 bits (377), Expect = 6e-36
Identities = 130/617 (21%), Positives = 271/617 (43%), Gaps = 20/617 (3%)
Query: 42 EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKK 101
E ++ M EK + ++ E++Q W + + + + L + F + K
Sbjct: 1081 EKRKGMLEKSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKD 1139
Query: 102 LLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKE 160
L ES+L+D++ DL + +++Q+++ Q E ++TA+ P + A
Sbjct: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTAS-PWKSARLM 1198
Query: 161 L----VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQ 216
+ + ER L + +ER +LL ++ E+ + D D+ W++E+
Sbjct: 1199 VHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNT 1258
Query: 217 TERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQ 276
G+ L +VQ +K++G R++ A G ++ + E A L AE ++ +L
Sbjct: 1259 DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
Query: 277 SAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLL 336
AW+ L + A++R+ L + ++++ D ++ +W+ L+ S++ KD LL
Sbjct: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396
++H + ++ + + + LL GH S +I ++ +D+ L++ +RR
Sbjct: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438
Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456
+ L+Q L R + E+W+A +E + + G + V L +K +F +
Sbjct: 1439 MMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ- 1497
Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 516
E++AA+ D+LI GH A ++ ++ + + W L M + L S+ L +F
Sbjct: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
Query: 517 SDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL------RAFEHDLQLLVSQVRQL 570
D E++ I EK L + P+ + + L +AFE +L ++R +
Sbjct: 1558 RDVDEIEAWISEK---LQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGV 1614
Query: 571 QEGAAQL--RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVR 628
+ L R AG +A+ +R + W+ L+ + + F++ ++
Sbjct: 1615 IDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK 1673
Query: 629 DLLSWMDGIASQIGAAD 645
D W+ + + + + D
Sbjct: 1674 DFDFWLSEVEALLASED 1690
Score = 144 bits (364), Expect = 2e-34
Identities = 107/382 (28%), Positives = 184/382 (48%), Gaps = 10/382 (2%)
Query: 265 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 324
AE ++ +Q+ + +E + R+Q L+ +++ + + D E+E W+ +++L + S++
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDE 70
Query: 325 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 384
KD + L+KH E V+ +I +L ++ GH SE I R ++ R
Sbjct: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 385 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 444
+ L E E+ + L Q L Q R+ ++ WI +KE + S ELGQD EHV VLQ+K
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 445 FSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQ 504
F EF ++ A ER+ VNQ +LI+ H + +D +N AW L L R
Sbjct: 191 FEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 505 LLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQ 561
L + E+ +F D E I+EK +L + +S+Q LR E DL
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKE----QLMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 562 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 621
L +V+ L A +L+ + A I + +E++ W+++ + + ++ +
Sbjct: 306 ALEDKVKALCAEADRLQQSHP-LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
Query: 622 RFHSQVRDLLSWMDGIASQIGA 643
RF + RDL SW+ + + I A
Sbjct: 365 RFLADFRDLTSWVTEMKALINA 386
Score = 121 bits (304), Expect = 2e-27
Identities = 126/658 (19%), Positives = 276/658 (41%), Gaps = 40/658 (6%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
+H+ F +LA + + + ++L+Q PE A +++K E+ Q W+ L +
Sbjct: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+L ++ + + F +L + + + + D+ + L++ Q ++++
Sbjct: 1334 KLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEID---A 1390
Query: 141 EVGELQA-----QTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQ 195
G QA Q AS E + ++ + + + L + +RR +L EL
Sbjct: 1391 RAGTFQAFEQFGQQLLAHGHYASPE-IKQKLDILDQERADLEKAWVQRRMMLDQCLELQL 1449
Query: 196 VAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAG 255
D + W+ R ++G+ L +V+ IKK++ + I ++ + A
Sbjct: 1450 FHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFAD 1509
Query: 256 ALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 315
L + + ++ W L+ ++ L + ++Q+ DV E+EAW+ E
Sbjct: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE 1569
Query: 316 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP------ 369
+ L + D+ + + +Q L K L Q + +E + + + R +++MG+
Sbjct: 1570 K--LQTASDESYKDPTNIQ-LSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626
Query: 370 ---DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426
+ + R + + + L + E+ L++ + + + + W++E E +
Sbjct: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686
Query: 427 GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD 486
S + G+D V+ L +K ++ A +RL +N D L+ + + + +D
Sbjct: 1687 ASEDYGKDLASVNNLLKKHQLLEADIS-AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRD 1745
Query: 487 GLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR------LTTPP 540
+N + ++ + +R L S LH+FF D + + I+EK+ + LT
Sbjct: 1746 TINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ 1805
Query: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600
R ++ L A E +Q ++ ++L + T+ E I R + ++ W
Sbjct: 1806 NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDD----NTI----GKEEIQQRLAQFVEHW 1857
Query: 601 KEL--LSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGL 656
KEL L+A RL S + +F + V + +W++ + + + D +++ GL
Sbjct: 1858 KELKQLAAARGQRLEES--LEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGL 1913
Score = 119 bits (299), Expect = 7e-27
Identities = 92/371 (24%), Positives = 168/371 (45%), Gaps = 2/371 (0%)
Query: 160 ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER 219
E + ER+ V +R R E RR+ L S D ++ W+QE+L +A E
Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA-SDEN 71
Query: 220 GNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW 279
+Q ++K+Q E+QA+ + ++ E + S +E +R L +L W
Sbjct: 72 YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
Query: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339
L E + L A ++ QY + +V W+ ++E ++ SE+ G+D + L KK
Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
Query: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVAL 399
+ + + +EE + ++++ L++ HP+ E I +Q +V+ + LK L +R+ L
Sbjct: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
Query: 400 EQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 459
+ + +R V E WI EKE + S + G+D V L K + A ++
Sbjct: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA-ALEDK 310
Query: 460 LAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDA 519
+ A+ D L + +A + ++ L W ++ L R L S L +F +D
Sbjct: 311 VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370
Query: 520 RELQGQIEEKR 530
R+L + E +
Sbjct: 371 RDLTSWVTEMK 381
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 185 bits (469), Expect = 1e-46
Identities = 143/643 (22%), Positives = 281/643 (43%), Gaps = 9/643 (1%)
Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIR 65
D + ED + ++ +HQ+ AE+ + ++E+ ++ + + E+R
Sbjct: 78 DKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELR 137
Query: 66 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 125
W L T K QL A K Q VQ A++ + + E+ V+ G D
Sbjct: 138 HLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLH 197
Query: 126 KKLQSMESQVEEWYREVGELQ--AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183
KK + + ++ V E+ A A P L+ +QN V RL +R
Sbjct: 198 KKFEDFQVELVAKEGRVVEVNQYANECAEENHP-DLPLIQSKQNEVNAAWERLRGLALQR 256
Query: 184 RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
++ L + L + D+ + + W++E+ P+ + G L A + ++GL R +
Sbjct: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVM 316
Query: 244 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 303
+++E+ +A L +A ++ E L S+W +R A R + L A + ++
Sbjct: 317 SDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFS 376
Query: 304 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 363
D E+ W+ E+ + +++ D LL +H Q + +++Y++ + L
Sbjct: 377 SDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDL 436
Query: 364 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423
+ H S+++ + +D + AL EL +ER EQ + R +++ W++ +E
Sbjct: 437 VNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQE 496
Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 483
+ +LG L +K +F E A E++ V++ +LI H + +
Sbjct: 497 AFLENEDLGNSLGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
Query: 484 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPR 543
+DGL L E TR +LL S L K + D+ +L+ I K+++L + +
Sbjct: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWI-NKKKKLADDEDYKDIQ 614
Query: 544 PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA-EAIASREQEVLQGWKE 602
S +Q+ + FE +L + +Q+ +Q+ ++ + G +A + + +R EV W+E
Sbjct: 615 NLKSRVQKQ-QVFEKELAVNKTQLENIQKTGQEM--IEGGHYASDNVTTRLSEVASLWEE 671
Query: 603 LLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
LL A + + L+F + DL W++ + Q+ + D
Sbjct: 672 LLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSED 714
Score = 164 bits (415), Expect = 2e-40
Identities = 116/378 (30%), Positives = 184/378 (48%), Gaps = 3/378 (0%)
Query: 3 MARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG 62
+A D +D L R + Q F ELA NK LE I++ GQ++++ + +V +L
Sbjct: 604 LADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLS 663
Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVN 122
E+ W EL T+ K QL EA++ Q + +L + L +E Q+ D G LA V
Sbjct: 664 EVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQ 723
Query: 123 SQLKKLQSMESQVEEWYREVGELQAQTAALPL--EPASKELVGERQNAVGERLVRLLEPL 180
++L+K +ES V +V L A P SK+ + RQ ++ R L EPL
Sbjct: 724 NRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKD-IRARQESLVCRFEALKEPL 782
Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
R++ LL L + D +DE AW+QE P A T G L A ++ + +++ + I
Sbjct: 783 ATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENI 842
Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
+H PR++E+ ER + AE V ++ L LR A RRQ L+A Q +
Sbjct: 843 ASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQ 902
Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
QY D+ E E W+ E+E ++ + + G DE++ LLKKH + ++ +S+ L Q
Sbjct: 903 QYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQA 962
Query: 361 RALLEMGHPDSEQISRRQ 378
A + E ++ Q
Sbjct: 963 NACQQQQAAPVEGVAGEQ 980
Score = 160 bits (406), Expect = 3e-39
Identities = 126/511 (24%), Positives = 226/511 (44%), Gaps = 10/511 (1%)
Query: 4 ARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP--ELAASVRKKL 61
A D + +D + +++L+HQ F E+ E + + G L++ +++++L
Sbjct: 1523 ACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582
Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
++++ W L T K ++L EAS+ + S + + L E+ L D DLA+
Sbjct: 1583 EQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASA 1642
Query: 122 NSQLKKLQSMESQV---EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178
+ LKK Q +E ++ E+ +++ L L + + + ++++ V +R + + E
Sbjct: 1643 GNLLKKHQLLEREMLAREDALKDLNTLAEDL--LSSGTFNVDQIVKKKDNVNKRFLNVQE 1700
Query: 179 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 238
L + L Q DLDDE +W++E+L + G LQ VQ +KK++ L
Sbjct: 1701 LAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEG 1760
Query: 239 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 298
E+ AH P ++ VL+ A L + E ++ L Q W L+E A+ R L+ + +
Sbjct: 1761 ELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLE 1820
Query: 299 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 358
Q+ + E EAW+ E+ L + D G +T LL KH LE +E + +
Sbjct: 1821 YLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCA 1880
Query: 359 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGE---ERRVALEQQYWLYQLSRQVSEL 415
Q +L + Q S+++ L L + ++ LE Y + + + +
Sbjct: 1881 QGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVV 1940
Query: 416 EHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH 475
E WIA+KE + G D L K + +ERL + + D+LI H
Sbjct: 1941 EAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQH 2000
Query: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLL 506
+ + E L + W +LLE Q L
Sbjct: 2001 NQSKAIEERYAALLKRWEQLLEASAVHRQKL 2031
Score = 143 bits (360), Expect = 6e-34
Identities = 132/564 (23%), Positives = 236/564 (41%), Gaps = 22/564 (3%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
RHQ E+ + + + GQ L+ E + VR+K+ + W L + R
Sbjct: 411 RHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHR 470
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Q + + ++D + E+ L++ D G L + + L+K + E
Sbjct: 471 QYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEE 530
Query: 141 EVGELQAQTAALPLEPASKELVG------ERQNAVGERLVRLLEPLQE----RRRLLLAS 190
++ + ++ + +L+G E A+ + L+ + L+E RRRLL S
Sbjct: 531 KI---------ITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKES 581
Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
L ++ D DD W+ ++ LA E +Q ++ ++K Q +E+ + +LE +
Sbjct: 582 LLLQKLYEDSDDLKNWINKKKKLA-DDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENI 640
Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVE 310
+ + ++ V L ++ S W L EA +++ L A Q Q+ + +++
Sbjct: 641 QKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQ 700
Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
WL + E + SED GK L+KH LE V ++ + L+ E+GHPD
Sbjct: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPD 760
Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430
S+ I RQ + + ALKE R+ L L + R + E WI E E A S
Sbjct: 761 SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY 820
Query: 431 LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNE 490
LG+D L + E + R+ + + ++++E GH AA +A LN+
Sbjct: 821 LGKDLIASKKLLNRHRVIL-ENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQ 879
Query: 491 AWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ 550
L R L A+ + ++ +D E + I EK + T +A ++
Sbjct: 880 NMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDN-TNYGADEEAAGALL 938
Query: 551 RTLRAFEHDLQLLVSQVRQLQEGA 574
+ AF DL ++ L+ A
Sbjct: 939 KKHEAFLLDLNSFGDSMKALRNQA 962
Score = 128 bits (321), Expect = 2e-29
Identities = 109/485 (22%), Positives = 221/485 (45%), Gaps = 33/485 (6%)
Query: 162 VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGN 221
+ +RQ + + LL+ +ERRR LL +A++ D L W+QE+ G
Sbjct: 1053 ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAENTGV 1108
Query: 222 GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA--SLRSPEAEAVRRGLEQLQSAW 279
L V + KK ++++ + PRL ++ + A L L +PE +R ++L S W
Sbjct: 1109 ELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR---QELNSRW 1165
Query: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339
L+ A+ ++Q+L +A VE ++ + + + + ++ + + D G D S L ++H
Sbjct: 1166 GSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRH 1225
Query: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPD-SEQISRRQSQVDRLYVALKELGEERRVA 398
E+ + + + L L E HPD +E + R++ +++ + L+ ++R+ +
Sbjct: 1226 EGFERDLVPLGDKVTILGETAERLSE-SHPDATEDLQRQKMELNEAWEDLQGRTKDRKES 1284
Query: 399 LEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRE 458
L + Y + +L++WI+ + S EL +D + +L E+ E ++ A
Sbjct: 1285 LNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADM-EAEAP 1343
Query: 459 RLAAVNQMVDELIECGHTAAATMAE-------WKDGLNEAWAELLELMGTRAQLLAASRE 511
A+ ELI+ GH A+ + + +D L +AW + R ++L E
Sbjct: 1344 TFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK-------RKKILDQCLE 1396
Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571
L F + +++ + + L + + S S++ ++ + + + +Q ++
Sbjct: 1397 LQMFQGNCDQVESWMVARENSL-----RSDDKSSLDSLEALMKKRDDLDKAITAQEGKIT 1451
Query: 572 EGAAQLRTVYAGEH--AEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRD 629
+ ++ A EH E IA+R Q VL WK L + D R + A+ +F+ + +
Sbjct: 1452 DLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEE 1511
Query: 630 LLSWM 634
L W+
Sbjct: 1512 LEEWI 1516
Score = 125 bits (315), Expect = 1e-28
Identities = 116/483 (24%), Positives = 199/483 (41%), Gaps = 20/483 (4%)
Query: 160 ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER 219
E + ER+ V R E + ER + L S L D DD W+ E++ +
Sbjct: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY 81
Query: 220 GNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW 279
+ +Q +K+Q L E+Q + E+ + ++ E + +E+L+ W
Sbjct: 82 EDPTN-IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140
Query: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339
L E + L A + +QY + A++ W+G++E + S + G+D + T L KK
Sbjct: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200
Query: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVAL 399
+ + E + ++++ E HPD I +Q++V+ + L+ L +R+ AL
Sbjct: 201 EDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKAL 260
Query: 400 EQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 459
L + R V+E WI EKE V S + G+D L F S G+
Sbjct: 261 SNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKD------LVASEGLFHSHKGL--ERN 312
Query: 460 LAAVNQMVDEL------IECGHTA-AATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 512
LA ++ V EL + H + A + E K+ L +W + L +R + L A+
Sbjct: 313 LAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWY 372
Query: 513 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQE 572
H+F SD EL G + EK + P + + R + +H++ + + E
Sbjct: 373 HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRH-QQHKHEIDSYDDRFQSADE 431
Query: 573 GAAQLRTVYAGEHAEAIASREQEVL-QGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631
L V A A + E+L W LL ++ D F+ +
Sbjct: 432 TGQDL--VNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVD 489
Query: 632 SWM 634
SWM
Sbjct: 490 SWM 492
Score = 117 bits (292), Expect = 5e-26
Identities = 92/386 (23%), Positives = 179/386 (46%), Gaps = 10/386 (2%)
Query: 265 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 324
AE ++ +++ + + +E R Q L+ ++ ++ + D ++ W+ E+ ++ D
Sbjct: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILT--D 78
Query: 325 KGKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383
K ++ + +Q +KH LE V+ +++L + MGH E+ ++
Sbjct: 79 KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRH 138
Query: 384 LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQE 443
L+ L EL E+ L + Q ++ +++ WI +KE +A S ELG+D+E VL +
Sbjct: 139 LWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHK 198
Query: 444 KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRA 503
KF +F E +A R+ VNQ +E E H + ++ +N AW L L R
Sbjct: 199 KFEDFQVEL-VAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257
Query: 504 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS--MQRTLRAFEHDLQ 561
+ L+ + L +F D E I+EK P LT+ + +S + + + E +L
Sbjct: 258 KALSNAANLQRFKRDVTEAIQWIKEKE---PVLTSEDYGKDLVASEGLFHSHKGLERNLA 314
Query: 562 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 621
++ +V++L A +L T+ A I +++++ W+ + + + +T
Sbjct: 315 VMSDKVKELCAKAEKL-TLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYH 373
Query: 622 RFHSQVRDLLSWMDGIASQIGAADKP 647
RF S +L WM+ + I A + P
Sbjct: 374 RFSSDFDELSGWMNEKTAAINADELP 399
Score = 115 bits (287), Expect = 2e-25
Identities = 124/634 (19%), Positives = 269/634 (42%), Gaps = 40/634 (6%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
RH+ F +L + + + ++L + P+ ++++ E+ + W +L+ T+ +
Sbjct: 1224 RHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKE 1283
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
L EA K + +L + + + + DL + L++ Q + +E
Sbjct: 1284 SLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA--- 1340
Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGE--------RLVR--LLEPLQERRRLLLAS 190
E QA LE S EL+ +A E +L R L + ++R+++L
Sbjct: 1341 EAPTFQA------LEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQC 1394
Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
EL + D +W+ R +++++ + L +++ +KK L + I A ++ ++
Sbjct: 1395 LELQMFQGNCDQVESWMVAR-ENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDL 1453
Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEV 309
A +L + E + L+++ W L+ + + R ++ D A ++Q+Y D+ E+
Sbjct: 1454 EHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYA-NLKQFYRDLEEL 1512
Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
E W+ E L ++ KD + + KH V+ E + + +L+E
Sbjct: 1513 EEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSAC 1571
Query: 370 DS------EQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423
D EQ+ + + D L + G++ A QQ + + + + E W++E E
Sbjct: 1572 DGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQ----RFNTSIRDFEFWLSEAE 1627
Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 483
+ + +D L +K E +A + L +N + ++L+ G + +
Sbjct: 1628 TLLAMKDQARDLASAGNLLKKHQLLEREM-LAREDALKDLNTLAEDLLSSGTFNVDQIVK 1686
Query: 484 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPR 543
KD +N+ + + EL + L + L +FF D + + IEEK L R+++ R
Sbjct: 1687 KKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEK---LIRVSSQDYGR 1743
Query: 544 --PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWK 601
++ + + E +L ++ + + A +L+ A E I R + ++ W+
Sbjct: 1744 DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKD-KAAVGQEEIQLRLAQFVEHWE 1802
Query: 602 ELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635
+L + L + + + L+F + +W++
Sbjct: 1803 KLKELAKARGLKLEESLEYLQFMQNAEEEEAWIN 1836
Score = 108 bits (270), Expect = 2e-23
Identities = 139/650 (21%), Positives = 271/650 (41%), Gaps = 28/650 (4%)
Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE---KPELAASVRKKLGEIRQ 66
+D +L K++ F +L N+ L I + L+ E PE A +R+ E+
Sbjct: 1111 DDVWELQKKF---DEFQKDLNTNEPRLRDINKVADDLLFEGLLTPE-GAQIRQ---ELNS 1163
Query: 67 CWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQ-LQDVDPGGDLATVNSQL 125
W L+ + RQL ++ A ++ A+ K+ + + Q L DPG DL +V +
Sbjct: 1164 RWGSLQRLADEQ-RQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQ 1222
Query: 126 KKLQSMESQVEEWYREVGELQAQTAAL-PLEPASKELVGERQNAVGERLVRLLEPLQERR 184
++ + E + +V L L P + E + ++ + E L ++R+
Sbjct: 1223 RRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRK 1282
Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244
L +++ + D W+ + E L ++ ++++Q R +++A
Sbjct: 1283 ESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEA 1342
Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304
P + + + + L + + + L+ ++ L +A E+R+++LD +++ +
Sbjct: 1343 PTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQG 1402
Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364
+ +VE+W+ +E + S+DK + S L+KK L++ + E I L +L+
Sbjct: 1403 NCDQVESWMVARENSLRSDDKSSLD-SLEALMKKRDDLDKAITAQEGKITDLEHFAESLI 1461
Query: 365 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 424
H E+I+ R +V + ALK + R L L Q R + ELE WI+E +
Sbjct: 1462 ADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM-L 1520
Query: 425 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGR-ERLAAVNQMVDELIECGHTAA--ATM 481
E +D ++ K FA E + GR E++ V + + LIEC M
Sbjct: 1521 PTACDESYKDATNIQRKYLKHQTFAHE--VDGRSEQVHGVINLGNSLIECSACDGNEEAM 1578
Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541
E + L E W LLE + + L + +F + R+ + + E L +
Sbjct: 1579 KEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLL-AMKDQAR 1637
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWK 601
SA ++ + + E ++ ++ L A L + + + I ++ V K
Sbjct: 1638 DLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLS-SGTFNVDQIVKKKDNVN---K 1693
Query: 602 ELLSACEDARLHVSSTADA---LRFHSQVRDLLSWMDGIASQIGAADKPR 648
L+ E A H +A +F + D SW++ ++ + D R
Sbjct: 1694 RFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGR 1743
Score = 83.2 bits (204), Expect = 7e-16
Identities = 120/634 (18%), Positives = 252/634 (39%), Gaps = 52/634 (8%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
RH+ + +A ++ +++I G ++++E A V ++ + Q L + +
Sbjct: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQN 893
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
L + Q + E + + E + + + G D + LKK ++ + +
Sbjct: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGD 953
Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER--RRLLLASKELHQVAH 198
+ L+ Q A + A+ + GE+ V L Q R R + + ++ +
Sbjct: 954 SMKALRNQANACQQQQAAPV-----EGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLS 1008
Query: 199 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258
++ + W E A Q I +RR P L +
Sbjct: 1009 SINKDW-WKVEA--------------ADHQGIVPAVYVRRLAHDEFPMLPQ--------- 1044
Query: 259 SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQEL 318
R E + + EQ+++ + L + AE R++ L + ++ ++ W+ E++
Sbjct: 1045 -RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK- 1102
Query: 319 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG--HPDSEQISR 376
+E+ G + +L KK + ++ + E + +++ LL G P+ QI
Sbjct: 1103 ---AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQI-- 1157
Query: 377 RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFE 436
+ +++ + +L+ L +E+R L + + R+ + + I +K + + G D
Sbjct: 1158 -RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLF 1216
Query: 437 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELL 496
V LQ + F + G +++ + + + L E A + K LNEAW +L
Sbjct: 1217 SVQALQRRHEGFERDLVPLG-DKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQ 1275
Query: 497 ELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL-RA 555
R + L +++ + F S AR+LQ I + + + E + ++ L R
Sbjct: 1276 GRTKDRKESLNEAQKFYLFLSKARDLQNWISS----IGGMVSSQELAEDLTGIEILLERH 1331
Query: 556 FEH--DLQLLVSQVRQLQEGAAQLRTVYAGEHAE-AIASREQEVLQGWKELLSACEDARL 612
EH D++ + L++ +A+L + +G HA I + Q V +L A E +
Sbjct: 1332 QEHRADMEAEAPTFQALEDFSAEL--IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKK 1389
Query: 613 HVSSTADALRFHSQVRDLLSWMDGIASQIGAADK 646
+ + F + SWM + + + DK
Sbjct: 1390 ILDQCLELQMFQGNCDQVESWMVARENSLRSDDK 1423
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 97.1 bits (240), Expect = 5e-20
Identities = 136/675 (20%), Positives = 286/675 (42%), Gaps = 65/675 (9%)
Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 74
L ++ H+ +A++K ++K+ + G QL++ P S+++K +++++
Sbjct: 3916 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3975
Query: 75 TQAKARQLFEA--------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ-- 124
+ +A L EA K DQ+++S + ++L S +V+ + + N
Sbjct: 3976 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVS 4035
Query: 125 --LKKLQ----SMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNA---VGERLVR 175
++KLQ +++ + EE G +A ++ ++V +N V ER +
Sbjct: 4036 VDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAK 4095
Query: 176 LLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228
LL+ ++ + L++ K+ DL+D G V+Q
Sbjct: 4096 LLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----------------GIDPSVVKQ 4139
Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAE 287
+ + +R EI L+ V+ L A+ P+ V++ +++L SAW L +A +
Sbjct: 4140 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK 4199
Query: 288 RRQQVLDAAFQVEQYYFD-VAEVEAW--LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344
R L+ A Q Y D + V W + +L MS G D ++ Q +++ Q +
Sbjct: 4200 DRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKS 4258
Query: 345 GVENYEESIAQLSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQ 402
+ + +L+ Q LL+ +S++ + ++ ++ +L+E R+ LE
Sbjct: 4259 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4318
Query: 403 YW-LYQLSRQVSELEHWIAEKE-VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460
L Q + EL W+ E +++ +G D + + + K ++ +A + +
Sbjct: 4319 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTV 4377
Query: 461 AAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAELLELMGTRAQLL-AASRELHKFFSD 518
AVN+ ++LIE A+ + K + LN+ W +LE R Q L A R+ F +
Sbjct: 4378 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGE 4437
Query: 519 ARELQGQIEEKRRRL----PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA 574
+LQ + + R L P P + + AFE + S +++ Q+
Sbjct: 4438 IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML 4497
Query: 575 AQLRTVYAGEHAEAIASRE-QEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLS 632
A+ + AE ++ + + W+ + + + + + + A+ FH+ ++D ++
Sbjct: 4498 AR-----CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4552
Query: 633 WMDGIASQIGAADKP 647
W+ + A +P
Sbjct: 4553 WLTQAEQTLNVASRP 4567
Score = 68.9 bits (167), Expect = 1e-11
Identities = 114/593 (19%), Positives = 241/593 (40%), Gaps = 63/593 (10%)
Query: 92 VQSFAELDKKLLHMESQLQDVDPGGD-LATVNSQLKKLQSMESQVEEWYREVGELQAQT- 149
+Q + M SQ + D D +A V + LQ + ++ + +++ L A
Sbjct: 3113 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3172
Query: 150 -------AALPLEPASKELVGERQN--AVGERLVRLLEPLQERRRLLLAS-KELHQVAHD 199
L E S +LVG +++ A+ ++ +LL+ Q R + + K L +
Sbjct: 3173 NANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3232
Query: 200 LDDELAWVQE-------RLPLAMQTERGNGLQAV-----QQHIKKNQGLRREIQAHGPRL 247
L + +Q+ + P+ M+TE N + ++ I+ QG ++++ G L
Sbjct: 3233 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3292
Query: 248 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQVEQYYFDV 306
+ ++ +S + + L+ + + W L ++ A+R Q+ +A ++ +
Sbjct: 3293 IQ--------SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3344
Query: 307 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESIAQLSRQCRA 362
+ +W+ + E L+ ++ K + +++K +Q L++ +++ + ++ + R+
Sbjct: 3345 ESLLSWMVDTEELVANQ---KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3401
Query: 363 LLEMGHP-DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE-LEHWIA 420
+ P D +I ++ S +D + AL E R LE + Q + E L W+
Sbjct: 3402 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3461
Query: 421 --EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
EK +V P Q S L+E+ ++ A + + N+ + + + G +
Sbjct: 3462 TIEKRLVNCEPIGTQ----ASKLEEQIAQHK-----ALEDDIINHNKHLHQAVSIGQSLK 3512
Query: 479 AT-------MAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFS-DARELQGQIEEK 529
M + K ++ W E+ E +R++LL + K F D EL + E
Sbjct: 3513 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEV 3572
Query: 530 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 589
+L +L+ Q LR + D+ L V Q +L G+ I
Sbjct: 3573 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3632
Query: 590 ASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLSWMDGIASQI 641
+ + + +K++ D + A R HS +L +W+D + ++
Sbjct: 3633 QDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3685
Score = 66.6 bits (161), Expect = 7e-11
Identities = 120/645 (18%), Positives = 256/645 (39%), Gaps = 51/645 (7%)
Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
LR Q L E L++ + ++Q+K E + K + ++ A+ A
Sbjct: 3605 LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3664
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
R+L S ++L +++ +LL E+Q+ + +LKK + +
Sbjct: 3665 RRLH--STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3722
Query: 140 REVGELQAQTAALPLEPASKELVGE---RQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
EV + +++V E R V + + + +E + +L S++ Q
Sbjct: 3723 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA---ILRSQQFDQA 3779
Query: 197 AHDLDDELAWVQE---RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253
A D EL+W+ E +L + Q ++K EI H ++++++
Sbjct: 3780 A---DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT--FTMEILRHKDIIDDLVKS 3834
Query: 254 AGALASLRSPEA-EAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVAEVEA 311
+ + S E +++++ L+++ + + + +ER Q+ A V Q++ E+
Sbjct: 3835 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3894
Query: 312 WLGEQELLMMSEDKGKDEQSTL-QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
WL E + ++ E TL Q ++H QL + + ++ I ++++ LLE+ +
Sbjct: 3895 WLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGE 3954
Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQ------------QYWLYQLSRQVSELEHW 418
I + D LY +KE ++R VAL++ L L R V L
Sbjct: 3955 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4014
Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
+ V E + ++VSV EK G E +A ++ +A
Sbjct: 4015 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI------SA 4068
Query: 479 ATMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537
+ + D + W + L+ R A+LL KF+ D L I++ + + L
Sbjct: 4069 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLE 4128
Query: 538 TP-------PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 590
P + + +A +++ + + +L ++++ +L + + + +
Sbjct: 4129 DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELN 4188
Query: 591 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635
S + + WK+ + E+A A+++ ++ + W+D
Sbjct: 4189 SAWDSLNKAWKDRIDKLEEA------MQAAVQYQDGLQAVFDWVD 4227
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/361 (23%), Positives = 169/361 (46%), Gaps = 40/361 (11%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELESTTQAK 78
++++F AEL QN +++++ + +L++E P+ + R K L EI W EL T +
Sbjct: 2500 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2559
Query: 79 ARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVE 136
++L E+S Q A+L + L+ E + + P D +N+Q +++Q + ++
Sbjct: 2560 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL---LQ 2616
Query: 137 EWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER----RR 185
E+ + + TAA P E P+ + +V E+ AV ++ L L +R +
Sbjct: 2617 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2676
Query: 186 LLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
++ S + + L D+L+ + +L LA+ T A+ Q ++ Q +++EIQ
Sbjct: 2677 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMKQEIQQE 2732
Query: 244 GPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
++ + + E AL +AE + R LE + ++ + + AE Q L +A
Sbjct: 2733 KKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2791
Query: 301 QYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ-LEQGVENYEESIAQLSR 358
+ ++ + +AWL D K+EQ+ + L LE ++++++ L+
Sbjct: 2792 HQFQQMSRDFQAWL----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2841
Query: 359 Q 359
Q
Sbjct: 2842 Q 2842
Score = 54.3 bits (129), Expect = 4e-07
Identities = 124/668 (18%), Positives = 248/668 (37%), Gaps = 80/668 (11%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
H+ F L EK EG+ L+ + + A+++ +L I+ W + +
Sbjct: 2832 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2891
Query: 81 QLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
+L E+ KA + + L + ++ L+++ D A + + KL+S++ ++++ +
Sbjct: 2892 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2951
Query: 140 REVGELQAQTA--ALPLEPASKELVGERQNAVGERLVRLLEPLQERR----RLLLASKEL 193
V EL TA L + KE+V + ++ +++ + E L ++ + KE
Sbjct: 2952 GMV-ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEF 3010
Query: 194 HQVAHDLDDELAWVQERLP----LAMQTERGNGLQAVQQHIKKNQGLRREIQ-------- 241
+V+ + +L +E+L L Q L +Q K Q L+ ++
Sbjct: 3011 QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3070
Query: 242 -----AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296
+ +VL + +A S ++ V L++ G+ +++
Sbjct: 3071 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3130
Query: 297 FQVEQYYFDVAEV--------------EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQL 342
+ + +A V +A+L + E LM S D T +++ +
Sbjct: 3131 AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN---KTCKMMLATEET 3187
Query: 343 EQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQ 402
+ + + LS+QC LL+ EQ+ +++ Y LKE + L++
Sbjct: 3188 SPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS----ILLQK- 3242
Query: 403 YWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462
AE+ + P +G + E ++ F F E + +
Sbjct: 3243 -----------------AEEHEESQGP-VGMETETINQQLNMFKVFQKEEIEPLQGKQQD 3284
Query: 463 VNQMVDELIECGHTAAAT--MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 520
VN + LI+ + +T + D +N W L + + RA L + F DA
Sbjct: 3285 VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3344
Query: 521 ELQGQIEEKRRRLPRLTTPPEPR----PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576
E L PP + Q+ L+ D + V +++ E A
Sbjct: 3345 ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT 3404
Query: 577 LRTVYAGEHAEAIASREQEVL--QGWKELLSACEDARLHVSS-TADALRFHSQVRDLLSW 633
E A+ + +Q L W+ LL+ E + + A +FH + L W
Sbjct: 3405 -----TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3459
Query: 634 MDGIASQI 641
+ I ++
Sbjct: 3460 LTTIEKRL 3467
Score = 53.9 bits (128), Expect = 5e-07
Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%)
Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 362
V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A
Sbjct: 637 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 696
Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422
L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK
Sbjct: 697 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 747
Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482
E + + + +++ ++ +E E E + +V ++ ++L+ H A T+
Sbjct: 748 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 806
Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535
++ + W+ +L+L Q + + +FF+DA+E + + + R
Sbjct: 807 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 859
Score = 52.0 bits (123), Expect = 2e-06
Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%)
Query: 48 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 107
Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + +
Sbjct: 454 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 507
Query: 108 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 153
+ V G + T + + + + + G Q+ T +L
Sbjct: 508 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 567
Query: 154 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ PA LV + V ++ L+ +Q R+ LL +S +
Sbjct: 568 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 627
Query: 197 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
+ + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E
Sbjct: 628 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 687
Query: 251 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
+ A L+ AE + R L+S +A L + +++ LD + +
Sbjct: 688 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 740
Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
WL E+E ++ D + + + H +L + ++ EE+I + LL HP
Sbjct: 741 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 800
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 414
I E R A++ Q+ W+ QL + V +
Sbjct: 801 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 828
Score = 49.7 bits (117), Expect = 9e-06
Identities = 128/682 (18%), Positives = 268/682 (39%), Gaps = 83/682 (12%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQAKA 79
+H ++ ++ +E + + G L++ E A++++ KL + Q W + T+ +
Sbjct: 4362 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4421
Query: 80 RQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VNSQLKKLQSMES 133
+QL A + A +L + L E L P G L +N ++ + E+
Sbjct: 4422 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4481
Query: 134 QVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKE 192
+ EE Y+ + +Q L P S E + + N + E+ + L ER+ L +
Sbjct: 4482 K-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4538
Query: 193 LHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
L H+ L D + W+ Q L + + L V I +++ E+ +H ++ E
Sbjct: 4539 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIE- 4597
Query: 251 LERAGA-----------------LASLRSPEAEAVRRGLE-------------QLQSAWA 280
L++ G L S++S + V+R +E Q AW+
Sbjct: 4598 LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4657
Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE----QELLMMSEDKGKDEQSTLQLL 336
L E E ++ LD+ ++ D +++ L + Q+ L T + L
Sbjct: 4658 KLMEWLEESEKSLDSELEIAN---DPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4714
Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396
K+ L ++ +++L + + + RQ++++ + + + +
Sbjct: 4715 KEKTSLADDNLKLDDMLSELRDKWDTI-------CGKSVERQNKLEEALLFSGQFTDALQ 4767
Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456
++ WLY++ Q +AE + V G D + V L + F E G
Sbjct: 4768 ALID---WLYRVEPQ-------LAEDQPVHG------DIDLVMNLIDNHKAFQKELGKR- 4810
Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKF 515
+ A+ + ELIE ++ + L+ W + L + + +L AA R+ +F
Sbjct: 4811 TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEF 4870
Query: 516 FSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575
S L + E + L P+ + ++ + F ++ L + +L +
Sbjct: 4871 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATT 4927
Query: 576 QLRTVYAGEHAEAIASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LL 631
TV A H ++I + + + ++E+L+ + + ++S L ++ + LL
Sbjct: 4928 MGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALL 4987
Query: 632 SWMDGIASQIGAADKPRCPSSL 653
+W+ + + DK P +
Sbjct: 4988 AWLQWAETTLTDKDKEVIPQEI 5009
Score = 46.2 bits (108), Expect = 1e-04
Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%)
Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 164
M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E
Sbjct: 647 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 704
Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224
+ + + + +LL + + R L LH +EL W+ E+ + +
Sbjct: 705 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 761
Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284
+ + + L RE+ ++ V E A L P + +Q+ W+ + +
Sbjct: 762 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 821
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 341
+ +Q + +++ D E +L + + S D+ L+++ ++
Sbjct: 822 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 881
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 372
++ + Y+ +IA L + + ++++ +S+
Sbjct: 882 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 912
Score = 40.4 bits (93), Expect = 0.005
Identities = 85/454 (18%), Positives = 178/454 (39%), Gaps = 65/454 (14%)
Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95
L+++E E + L +EK E ++ Q W S T A + + + Q + S
Sbjct: 1454 LKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISKTLKDAEKAGKPPFSKQKISS- 1507
Query: 96 AELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQSMESQVEEWYR-----EVGELQ 146
E+ K + LQ + GD T + + +L+ ++E Y + +LQ
Sbjct: 1508 EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEKQVKTLQESYNLLFSESLKQLQ 1566
Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206
+ ++ K +V ERQ E+L + + L + L+ +E + D EL
Sbjct: 1567 ESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG-DGTVELKK 1624
Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----IQAHGPRLEEVLERAGALASLR 261
Q + +Q + QA+ + +K + +E Q +E+ L A
Sbjct: 1625 YQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1683
Query: 262 SPEAEAVRRGLEQLQS-----------AWAGLREAAERRQQVLDAAFQVEQ--------- 301
+ +AE ++ L+++ + A L E+ + + +LD V++
Sbjct: 1684 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1743
Query: 302 --------YYFDVAEVEAWLGEQE-----LLMMSEDK--GKDEQSTLQLLKKHLQLEQGV 346
+F + ++ +GE++ LL D G +++ Q +K + +
Sbjct: 1744 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKI 1803
Query: 347 ENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQVDRLY-VALKELGEERRVALE 400
+ +++ ++ + LLE + + E++ + ++ Y AL E ++ ++
Sbjct: 1804 ISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS 1863
Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD 434
Q L + +E EHW+ + E + E G D
Sbjct: 1864 LQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1897
Score = 40.4 bits (93), Expect = 0.005
Identities = 145/722 (20%), Positives = 282/722 (39%), Gaps = 131/722 (18%)
Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 62
+D + L + R ++F ++ +K L I G +++ E A S K+ G
Sbjct: 1897 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1952
Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 120
R+ +L+ T + R L+ SK + L + +L K H E + G AT
Sbjct: 1953 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2009
Query: 121 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 160
+ L + ++++ Q+EE G++ +Q A+ L PA +
Sbjct: 2010 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2069
Query: 161 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 218
+ + VG R L + + ER +L + V LD+ L W+ L Q +
Sbjct: 2070 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2128
Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 277
A+Q I KN L ++I + + E+ P A +++ ++ L +
Sbjct: 2129 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2188
Query: 278 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 328
++ EA+ + ++ L + +VE + +++ +L + + D GKD
Sbjct: 2189 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2245
Query: 329 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 369
++ST + L KKHL++ G+ + + E LS++ + + +
Sbjct: 2246 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2305
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
E ++ Q Q+D V +K L + W+ + +++V ++ G+
Sbjct: 2306 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2348
Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 487
+LG+ E LQEK+S E ++ N LI T A +A K G
Sbjct: 2349 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2403
Query: 488 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 541
LN E A E L + +++ H + L+ +I E +L +L E
Sbjct: 2404 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2463
Query: 542 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 575
P P+ + +T ++FE +L+ V++V++L++
Sbjct: 2464 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2523
Query: 576 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 632
+L + EA ++ E+ W+EL D + + +++ L +F + L
Sbjct: 2524 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2582
Query: 633 WM 634
W+
Sbjct: 2583 WL 2584
Score = 37.7 bits (86), Expect = 0.035
Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 83/465 (17%)
Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93
+W++++E +++ + +PE + ++ +L + + +E+E + SK D+ Q
Sbjct: 1333 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKMDE-CQ 1381
Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGELQAQTA 150
+AE + + +LQ + A V+SQ K K + M+S + +E +L+ +
Sbjct: 1382 KYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1437
Query: 151 ALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLDDELAW 206
AL L+ + G+ L RL E +E++ + +KEL + ++ L
Sbjct: 1438 AL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1491
Query: 207 VQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGALASLR 261
++ + P + Q + ++ + + Q ++ + HG ++ EE E + +L+
Sbjct: 1492 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1551
Query: 262 SPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYYFDVAE 308
L+QLQ + +E E+ Q + D Q E
Sbjct: 1552 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE-------- 1603
Query: 309 VEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ESIAQLS 357
+G QE M+ + + K QS + L+K +Q L + V+N E E+ +LS
Sbjct: 1604 -NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1662
Query: 358 RQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQYWLYQL 408
++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q L +
Sbjct: 1663 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ--LEES 1718
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 453
++ L W++ V S G +H V+++ + F G
Sbjct: 1719 KTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1759
Score = 35.4 bits (80), Expect = 0.17
Identities = 69/371 (18%), Positives = 144/371 (38%), Gaps = 57/371 (15%)
Query: 3 MARDGTRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 56
M DGT E +L K +AE+ +N E ++ G++L QE L
Sbjct: 1614 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL--- 1668
Query: 57 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 116
+ +KL E + +L + ++L D++V + + + + + QL++
Sbjct: 1669 IEQKLNEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE----- 1717
Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176
+ + L L +++ E + ++ Q E K +GE G L
Sbjct: 1718 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----L 1773
Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236
LE D+D ++ QE L Q + + + QH
Sbjct: 1774 LET-------------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH------- 1807
Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295
+ + + +LE+ G S E E +++ +++L+ + L E+ ++ +
Sbjct: 1808 -QAVIIATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1864
Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354
++E++ D E E WL + E + + + G D+ + L LK+ + V +++ +
Sbjct: 1865 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1924
Query: 355 QLSRQCRALLE 365
++ +LE
Sbjct: 1925 YITISGNRVLE 1935
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 97.1 bits (240), Expect = 5e-20
Identities = 136/675 (20%), Positives = 286/675 (42%), Gaps = 65/675 (9%)
Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 74
L ++ H+ +A++K ++K+ + G QL++ P S+++K +++++
Sbjct: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3986
Query: 75 TQAKARQLFEA--------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ-- 124
+ +A L EA K DQ+++S + ++L S +V+ + + N
Sbjct: 3987 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVS 4046
Query: 125 --LKKLQ----SMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNA---VGERLVR 175
++KLQ +++ + EE G +A ++ ++V +N V ER +
Sbjct: 4047 VDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAK 4106
Query: 176 LLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228
LL+ ++ + L++ K+ DL+D G V+Q
Sbjct: 4107 LLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----------------GIDPSVVKQ 4150
Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAE 287
+ + +R EI L+ V+ L A+ P+ V++ +++L SAW L +A +
Sbjct: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK 4210
Query: 288 RRQQVLDAAFQVEQYYFD-VAEVEAW--LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344
R L+ A Q Y D + V W + +L MS G D ++ Q +++ Q +
Sbjct: 4211 DRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKS 4269
Query: 345 GVENYEESIAQLSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQ 402
+ + +L+ Q LL+ +S++ + ++ ++ +L+E R+ LE
Sbjct: 4270 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4329
Query: 403 YW-LYQLSRQVSELEHWIAEKE-VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460
L Q + EL W+ E +++ +G D + + + K ++ +A + +
Sbjct: 4330 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTV 4388
Query: 461 AAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAELLELMGTRAQLL-AASRELHKFFSD 518
AVN+ ++LIE A+ + K + LN+ W +LE R Q L A R+ F +
Sbjct: 4389 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGE 4448
Query: 519 ARELQGQIEEKRRRL----PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA 574
+LQ + + R L P P + + AFE + S +++ Q+
Sbjct: 4449 IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML 4508
Query: 575 AQLRTVYAGEHAEAIASRE-QEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLS 632
A+ + AE ++ + + W+ + + + + + + A+ FH+ ++D ++
Sbjct: 4509 AR-----CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4563
Query: 633 WMDGIASQIGAADKP 647
W+ + A +P
Sbjct: 4564 WLTQAEQTLNVASRP 4578
Score = 68.9 bits (167), Expect = 1e-11
Identities = 114/593 (19%), Positives = 241/593 (40%), Gaps = 63/593 (10%)
Query: 92 VQSFAELDKKLLHMESQLQDVDPGGD-LATVNSQLKKLQSMESQVEEWYREVGELQAQT- 149
+Q + M SQ + D D +A V + LQ + ++ + +++ L A
Sbjct: 3124 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3183
Query: 150 -------AALPLEPASKELVGERQN--AVGERLVRLLEPLQERRRLLLAS-KELHQVAHD 199
L E S +LVG +++ A+ ++ +LL+ Q R + + K L +
Sbjct: 3184 NANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3243
Query: 200 LDDELAWVQE-------RLPLAMQTERGNGLQAV-----QQHIKKNQGLRREIQAHGPRL 247
L + +Q+ + P+ M+TE N + ++ I+ QG ++++ G L
Sbjct: 3244 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3303
Query: 248 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQVEQYYFDV 306
+ ++ +S + + L+ + + W L ++ A+R Q+ +A ++ +
Sbjct: 3304 IQ--------SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3355
Query: 307 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESIAQLSRQCRA 362
+ +W+ + E L+ ++ K + +++K +Q L++ +++ + ++ + R+
Sbjct: 3356 ESLLSWMVDTEELVANQ---KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3412
Query: 363 LLEMGHP-DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE-LEHWIA 420
+ P D +I ++ S +D + AL E R LE + Q + E L W+
Sbjct: 3413 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3472
Query: 421 --EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
EK +V P Q S L+E+ ++ A + + N+ + + + G +
Sbjct: 3473 TIEKRLVNCEPIGTQ----ASKLEEQIAQHK-----ALEDDIINHNKHLHQAVSIGQSLK 3523
Query: 479 AT-------MAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFS-DARELQGQIEEK 529
M + K ++ W E+ E +R++LL + K F D EL + E
Sbjct: 3524 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEV 3583
Query: 530 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 589
+L +L+ Q LR + D+ L V Q +L G+ I
Sbjct: 3584 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3643
Query: 590 ASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLSWMDGIASQI 641
+ + + +K++ D + A R HS +L +W+D + ++
Sbjct: 3644 QDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3696
Score = 66.6 bits (161), Expect = 7e-11
Identities = 120/645 (18%), Positives = 256/645 (39%), Gaps = 51/645 (7%)
Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
LR Q L E L++ + ++Q+K E + K + ++ A+ A
Sbjct: 3616 LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3675
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
R+L S ++L +++ +LL E+Q+ + +LKK + +
Sbjct: 3676 RRLH--STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3733
Query: 140 REVGELQAQTAALPLEPASKELVGE---RQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
EV + +++V E R V + + + +E + +L S++ Q
Sbjct: 3734 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA---ILRSQQFDQA 3790
Query: 197 AHDLDDELAWVQE---RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253
A D EL+W+ E +L + Q ++K EI H ++++++
Sbjct: 3791 A---DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT--FTMEILRHKDIIDDLVKS 3845
Query: 254 AGALASLRSPEA-EAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVAEVEA 311
+ + S E +++++ L+++ + + + +ER Q+ A V Q++ E+
Sbjct: 3846 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3905
Query: 312 WLGEQELLMMSEDKGKDEQSTL-QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
WL E + ++ E TL Q ++H QL + + ++ I ++++ LLE+ +
Sbjct: 3906 WLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGE 3965
Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQ------------QYWLYQLSRQVSELEHW 418
I + D LY +KE ++R VAL++ L L R V L
Sbjct: 3966 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4025
Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
+ V E + ++VSV EK G E +A ++ +A
Sbjct: 4026 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI------SA 4079
Query: 479 ATMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537
+ + D + W + L+ R A+LL KF+ D L I++ + + L
Sbjct: 4080 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLE 4139
Query: 538 TP-------PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 590
P + + +A +++ + + +L ++++ +L + + + +
Sbjct: 4140 DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELN 4199
Query: 591 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635
S + + WK+ + E+A A+++ ++ + W+D
Sbjct: 4200 SAWDSLNKAWKDRIDKLEEA------MQAAVQYQDGLQAVFDWVD 4238
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/361 (23%), Positives = 169/361 (46%), Gaps = 40/361 (11%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELESTTQAK 78
++++F AEL QN +++++ + +L++E P+ + R K L EI W EL T +
Sbjct: 2511 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2570
Query: 79 ARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVE 136
++L E+S Q A+L + L+ E + + P D +N+Q +++Q + ++
Sbjct: 2571 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL---LQ 2627
Query: 137 EWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER----RR 185
E+ + + TAA P E P+ + +V E+ AV ++ L L +R +
Sbjct: 2628 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2687
Query: 186 LLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
++ S + + L D+L+ + +L LA+ T A+ Q ++ Q +++EIQ
Sbjct: 2688 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMKQEIQQE 2743
Query: 244 GPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
++ + + E AL +AE + R LE + ++ + + AE Q L +A
Sbjct: 2744 KKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2802
Query: 301 QYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ-LEQGVENYEESIAQLSR 358
+ ++ + +AWL D K+EQ+ + L LE ++++++ L+
Sbjct: 2803 HQFQQMSRDFQAWL----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2852
Query: 359 Q 359
Q
Sbjct: 2853 Q 2853
Score = 54.3 bits (129), Expect = 4e-07
Identities = 124/668 (18%), Positives = 248/668 (37%), Gaps = 80/668 (11%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
H+ F L EK EG+ L+ + + A+++ +L I+ W + +
Sbjct: 2843 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2902
Query: 81 QLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
+L E+ KA + + L + ++ L+++ D A + + KL+S++ ++++ +
Sbjct: 2903 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2962
Query: 140 REVGELQAQTA--ALPLEPASKELVGERQNAVGERLVRLLEPLQERR----RLLLASKEL 193
V EL TA L + KE+V + ++ +++ + E L ++ + KE
Sbjct: 2963 GMV-ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEF 3021
Query: 194 HQVAHDLDDELAWVQERLP----LAMQTERGNGLQAVQQHIKKNQGLRREIQ-------- 241
+V+ + +L +E+L L Q L +Q K Q L+ ++
Sbjct: 3022 QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3081
Query: 242 -----AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296
+ +VL + +A S ++ V L++ G+ +++
Sbjct: 3082 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3141
Query: 297 FQVEQYYFDVAEV--------------EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQL 342
+ + +A V +A+L + E LM S D T +++ +
Sbjct: 3142 AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN---KTCKMMLATEET 3198
Query: 343 EQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQ 402
+ + + LS+QC LL+ EQ+ +++ Y LKE + L++
Sbjct: 3199 SPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS----ILLQK- 3253
Query: 403 YWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462
AE+ + P +G + E ++ F F E + +
Sbjct: 3254 -----------------AEEHEESQGP-VGMETETINQQLNMFKVFQKEEIEPLQGKQQD 3295
Query: 463 VNQMVDELIECGHTAAAT--MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 520
VN + LI+ + +T + D +N W L + + RA L + F DA
Sbjct: 3296 VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3355
Query: 521 ELQGQIEEKRRRLPRLTTPPEPR----PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576
E L PP + Q+ L+ D + V +++ E A
Sbjct: 3356 ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT 3415
Query: 577 LRTVYAGEHAEAIASREQEVL--QGWKELLSACEDARLHVSS-TADALRFHSQVRDLLSW 633
E A+ + +Q L W+ LL+ E + + A +FH + L W
Sbjct: 3416 -----TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3470
Query: 634 MDGIASQI 641
+ I ++
Sbjct: 3471 LTTIEKRL 3478
Score = 53.9 bits (128), Expect = 5e-07
Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%)
Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 362
V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A
Sbjct: 648 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 707
Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422
L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK
Sbjct: 708 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 758
Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482
E + + + +++ ++ +E E E + +V ++ ++L+ H A T+
Sbjct: 759 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 817
Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535
++ + W+ +L+L Q + + +FF+DA+E + + + R
Sbjct: 818 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 870
Score = 52.0 bits (123), Expect = 2e-06
Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%)
Query: 48 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 107
Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + +
Sbjct: 465 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 518
Query: 108 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 153
+ V G + T + + + + + G Q+ T +L
Sbjct: 519 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 578
Query: 154 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ PA LV + V ++ L+ +Q R+ LL +S +
Sbjct: 579 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 638
Query: 197 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
+ + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E
Sbjct: 639 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 698
Query: 251 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
+ A L+ AE + R L+S +A L + +++ LD + +
Sbjct: 699 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 751
Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
WL E+E ++ D + + + H +L + ++ EE+I + LL HP
Sbjct: 752 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 811
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 414
I E R A++ Q+ W+ QL + V +
Sbjct: 812 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 839
Score = 49.7 bits (117), Expect = 9e-06
Identities = 128/682 (18%), Positives = 268/682 (39%), Gaps = 83/682 (12%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQAKA 79
+H ++ ++ +E + + G L++ E A++++ KL + Q W + T+ +
Sbjct: 4373 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4432
Query: 80 RQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VNSQLKKLQSMES 133
+QL A + A +L + L E L P G L +N ++ + E+
Sbjct: 4433 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4492
Query: 134 QVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKE 192
+ EE Y+ + +Q L P S E + + N + E+ + L ER+ L +
Sbjct: 4493 K-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4549
Query: 193 LHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
L H+ L D + W+ Q L + + L V I +++ E+ +H ++ E
Sbjct: 4550 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIE- 4608
Query: 251 LERAGA-----------------LASLRSPEAEAVRRGLE-------------QLQSAWA 280
L++ G L S++S + V+R +E Q AW+
Sbjct: 4609 LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4668
Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE----QELLMMSEDKGKDEQSTLQLL 336
L E E ++ LD+ ++ D +++ L + Q+ L T + L
Sbjct: 4669 KLMEWLEESEKSLDSELEIAN---DPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725
Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396
K+ L ++ +++L + + + RQ++++ + + + +
Sbjct: 4726 KEKTSLADDNLKLDDMLSELRDKWDTI-------CGKSVERQNKLEEALLFSGQFTDALQ 4778
Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456
++ WLY++ Q +AE + V G D + V L + F E G
Sbjct: 4779 ALID---WLYRVEPQ-------LAEDQPVHG------DIDLVMNLIDNHKAFQKELGKR- 4821
Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKF 515
+ A+ + ELIE ++ + L+ W + L + + +L AA R+ +F
Sbjct: 4822 TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEF 4881
Query: 516 FSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575
S L + E + L P+ + ++ + F ++ L + +L +
Sbjct: 4882 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATT 4938
Query: 576 QLRTVYAGEHAEAIASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LL 631
TV A H ++I + + + ++E+L+ + + ++S L ++ + LL
Sbjct: 4939 MGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALL 4998
Query: 632 SWMDGIASQIGAADKPRCPSSL 653
+W+ + + DK P +
Sbjct: 4999 AWLQWAETTLTDKDKEVIPQEI 5020
Score = 46.2 bits (108), Expect = 1e-04
Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%)
Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 164
M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E
Sbjct: 658 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 715
Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224
+ + + + +LL + + R L LH +EL W+ E+ + +
Sbjct: 716 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 772
Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284
+ + + L RE+ ++ V E A L P + +Q+ W+ + +
Sbjct: 773 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 832
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 341
+ +Q + +++ D E +L + + S D+ L+++ ++
Sbjct: 833 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 892
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 372
++ + Y+ +IA L + + ++++ +S+
Sbjct: 893 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 923
Score = 40.4 bits (93), Expect = 0.005
Identities = 85/454 (18%), Positives = 178/454 (39%), Gaps = 65/454 (14%)
Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95
L+++E E + L +EK E ++ Q W S T A + + + Q + S
Sbjct: 1465 LKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISKTLKDAEKAGKPPFSKQKISS- 1518
Query: 96 AELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQSMESQVEEWYR-----EVGELQ 146
E+ K + LQ + GD T + + +L+ ++E Y + +LQ
Sbjct: 1519 EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEKQVKTLQESYNLLFSESLKQLQ 1577
Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206
+ ++ K +V ERQ E+L + + L + L+ +E + D EL
Sbjct: 1578 ESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG-DGTVELKK 1635
Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----IQAHGPRLEEVLERAGALASLR 261
Q + +Q + QA+ + +K + +E Q +E+ L A
Sbjct: 1636 YQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1694
Query: 262 SPEAEAVRRGLEQLQS-----------AWAGLREAAERRQQVLDAAFQVEQ--------- 301
+ +AE ++ L+++ + A L E+ + + +LD V++
Sbjct: 1695 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1754
Query: 302 --------YYFDVAEVEAWLGEQE-----LLMMSEDK--GKDEQSTLQLLKKHLQLEQGV 346
+F + ++ +GE++ LL D G +++ Q +K + +
Sbjct: 1755 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKI 1814
Query: 347 ENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQVDRLY-VALKELGEERRVALE 400
+ +++ ++ + LLE + + E++ + ++ Y AL E ++ ++
Sbjct: 1815 ISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS 1874
Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD 434
Q L + +E EHW+ + E + E G D
Sbjct: 1875 LQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1908
Score = 40.4 bits (93), Expect = 0.005
Identities = 145/722 (20%), Positives = 282/722 (39%), Gaps = 131/722 (18%)
Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 62
+D + L + R ++F ++ +K L I G +++ E A S K+ G
Sbjct: 1908 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1963
Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 120
R+ +L+ T + R L+ SK + L + +L K H E + G AT
Sbjct: 1964 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2020
Query: 121 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 160
+ L + ++++ Q+EE G++ +Q A+ L PA +
Sbjct: 2021 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2080
Query: 161 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 218
+ + VG R L + + ER +L + V LD+ L W+ L Q +
Sbjct: 2081 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139
Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 277
A+Q I KN L ++I + + E+ P A +++ ++ L +
Sbjct: 2140 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2199
Query: 278 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 328
++ EA+ + ++ L + +VE + +++ +L + + D GKD
Sbjct: 2200 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2256
Query: 329 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 369
++ST + L KKHL++ G+ + + E LS++ + + +
Sbjct: 2257 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2316
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
E ++ Q Q+D V +K L + W+ + +++V ++ G+
Sbjct: 2317 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2359
Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 487
+LG+ E LQEK+S E ++ N LI T A +A K G
Sbjct: 2360 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2414
Query: 488 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 541
LN E A E L + +++ H + L+ +I E +L +L E
Sbjct: 2415 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2474
Query: 542 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 575
P P+ + +T ++FE +L+ V++V++L++
Sbjct: 2475 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2534
Query: 576 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 632
+L + EA ++ E+ W+EL D + + +++ L +F + L
Sbjct: 2535 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2593
Query: 633 WM 634
W+
Sbjct: 2594 WL 2595
Score = 37.7 bits (86), Expect = 0.035
Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 83/465 (17%)
Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93
+W++++E +++ + +PE + ++ +L + + +E+E + SK D+ Q
Sbjct: 1344 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKMDE-CQ 1392
Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGELQAQTA 150
+AE + + +LQ + A V+SQ K K + M+S + +E +L+ +
Sbjct: 1393 KYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1448
Query: 151 ALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLDDELAW 206
AL L+ + G+ L RL E +E++ + +KEL + ++ L
Sbjct: 1449 AL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1502
Query: 207 VQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGALASLR 261
++ + P + Q + ++ + + Q ++ + HG ++ EE E + +L+
Sbjct: 1503 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1562
Query: 262 SPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYYFDVAE 308
L+QLQ + +E E+ Q + D Q E
Sbjct: 1563 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE-------- 1614
Query: 309 VEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ESIAQLS 357
+G QE M+ + + K QS + L+K +Q L + V+N E E+ +LS
Sbjct: 1615 -NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1673
Query: 358 RQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQYWLYQL 408
++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q L +
Sbjct: 1674 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ--LEES 1729
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 453
++ L W++ V S G +H V+++ + F G
Sbjct: 1730 KTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1770
Score = 35.4 bits (80), Expect = 0.17
Identities = 69/371 (18%), Positives = 144/371 (38%), Gaps = 57/371 (15%)
Query: 3 MARDGTRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 56
M DGT E +L K +AE+ +N E ++ G++L QE L
Sbjct: 1625 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL--- 1679
Query: 57 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 116
+ +KL E + +L + ++L D++V + + + + + QL++
Sbjct: 1680 IEQKLNEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE----- 1728
Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176
+ + L L +++ E + ++ Q E K +GE G L
Sbjct: 1729 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----L 1784
Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236
LE D+D ++ QE L Q + + + QH
Sbjct: 1785 LET-------------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH------- 1818
Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295
+ + + +LE+ G S E E +++ +++L+ + L E+ ++ +
Sbjct: 1819 -QAVIIATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1875
Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354
++E++ D E E WL + E + + + G D+ + L LK+ + V +++ +
Sbjct: 1876 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1935
Query: 355 QLSRQCRALLE 365
++ +LE
Sbjct: 1936 YITISGNRVLE 1946
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 97.1 bits (240), Expect = 5e-20
Identities = 136/675 (20%), Positives = 286/675 (42%), Gaps = 65/675 (9%)
Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 74
L ++ H+ +A++K ++K+ + G QL++ P S+++K +++++
Sbjct: 4065 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 4124
Query: 75 TQAKARQLFEA--------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ-- 124
+ +A L EA K DQ+++S + ++L S +V+ + + N
Sbjct: 4125 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVS 4184
Query: 125 --LKKLQ----SMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNA---VGERLVR 175
++KLQ +++ + EE G +A ++ ++V +N V ER +
Sbjct: 4185 VDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAK 4244
Query: 176 LLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228
LL+ ++ + L++ K+ DL+D G V+Q
Sbjct: 4245 LLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----------------GIDPSVVKQ 4288
Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAE 287
+ + +R EI L+ V+ L A+ P+ V++ +++L SAW L +A +
Sbjct: 4289 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK 4348
Query: 288 RRQQVLDAAFQVEQYYFD-VAEVEAW--LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344
R L+ A Q Y D + V W + +L MS G D ++ Q +++ Q +
Sbjct: 4349 DRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKS 4407
Query: 345 GVENYEESIAQLSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQ 402
+ + +L+ Q LL+ +S++ + ++ ++ +L+E R+ LE
Sbjct: 4408 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4467
Query: 403 YW-LYQLSRQVSELEHWIAEKE-VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460
L Q + EL W+ E +++ +G D + + + K ++ +A + +
Sbjct: 4468 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTV 4526
Query: 461 AAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAELLELMGTRAQLL-AASRELHKFFSD 518
AVN+ ++LIE A+ + K + LN+ W +LE R Q L A R+ F +
Sbjct: 4527 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGE 4586
Query: 519 ARELQGQIEEKRRRL----PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA 574
+LQ + + R L P P + + AFE + S +++ Q+
Sbjct: 4587 IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML 4646
Query: 575 AQLRTVYAGEHAEAIASRE-QEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLS 632
A+ + AE ++ + + W+ + + + + + + A+ FH+ ++D ++
Sbjct: 4647 AR-----CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4701
Query: 633 WMDGIASQIGAADKP 647
W+ + A +P
Sbjct: 4702 WLTQAEQTLNVASRP 4716
Score = 68.9 bits (167), Expect = 1e-11
Identities = 114/593 (19%), Positives = 241/593 (40%), Gaps = 63/593 (10%)
Query: 92 VQSFAELDKKLLHMESQLQDVDPGGD-LATVNSQLKKLQSMESQVEEWYREVGELQAQT- 149
+Q + M SQ + D D +A V + LQ + ++ + +++ L A
Sbjct: 3262 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3321
Query: 150 -------AALPLEPASKELVGERQN--AVGERLVRLLEPLQERRRLLLAS-KELHQVAHD 199
L E S +LVG +++ A+ ++ +LL+ Q R + + K L +
Sbjct: 3322 NANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3381
Query: 200 LDDELAWVQE-------RLPLAMQTERGNGLQAV-----QQHIKKNQGLRREIQAHGPRL 247
L + +Q+ + P+ M+TE N + ++ I+ QG ++++ G L
Sbjct: 3382 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3441
Query: 248 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQVEQYYFDV 306
+ ++ +S + + L+ + + W L ++ A+R Q+ +A ++ +
Sbjct: 3442 IQ--------SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3493
Query: 307 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESIAQLSRQCRA 362
+ +W+ + E L+ ++ K + +++K +Q L++ +++ + ++ + R+
Sbjct: 3494 ESLLSWMVDTEELVANQ---KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3550
Query: 363 LLEMGHP-DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE-LEHWIA 420
+ P D +I ++ S +D + AL E R LE + Q + E L W+
Sbjct: 3551 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3610
Query: 421 --EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
EK +V P Q S L+E+ ++ A + + N+ + + + G +
Sbjct: 3611 TIEKRLVNCEPIGTQ----ASKLEEQIAQHK-----ALEDDIINHNKHLHQAVSIGQSLK 3661
Query: 479 AT-------MAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFS-DARELQGQIEEK 529
M + K ++ W E+ E +R++LL + K F D EL + E
Sbjct: 3662 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEV 3721
Query: 530 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 589
+L +L+ Q LR + D+ L V Q +L G+ I
Sbjct: 3722 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3781
Query: 590 ASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLSWMDGIASQI 641
+ + + +K++ D + A R HS +L +W+D + ++
Sbjct: 3782 QDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3834
Score = 66.6 bits (161), Expect = 7e-11
Identities = 120/645 (18%), Positives = 256/645 (39%), Gaps = 51/645 (7%)
Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
LR Q L E L++ + ++Q+K E + K + ++ A+ A
Sbjct: 3754 LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3813
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
R+L S ++L +++ +LL E+Q+ + +LKK + +
Sbjct: 3814 RRLH--STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3871
Query: 140 REVGELQAQTAALPLEPASKELVGE---RQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
EV + +++V E R V + + + +E + +L S++ Q
Sbjct: 3872 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA---ILRSQQFDQA 3928
Query: 197 AHDLDDELAWVQE---RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253
A D EL+W+ E +L + Q ++K EI H ++++++
Sbjct: 3929 A---DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT--FTMEILRHKDIIDDLVKS 3983
Query: 254 AGALASLRSPEA-EAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVAEVEA 311
+ + S E +++++ L+++ + + + +ER Q+ A V Q++ E+
Sbjct: 3984 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 4043
Query: 312 WLGEQELLMMSEDKGKDEQSTL-QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
WL E + ++ E TL Q ++H QL + + ++ I ++++ LLE+ +
Sbjct: 4044 WLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGE 4103
Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQ------------QYWLYQLSRQVSELEHW 418
I + D LY +KE ++R VAL++ L L R V L
Sbjct: 4104 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4163
Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
+ V E + ++VSV EK G E +A ++ +A
Sbjct: 4164 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI------SA 4217
Query: 479 ATMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537
+ + D + W + L+ R A+LL KF+ D L I++ + + L
Sbjct: 4218 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLE 4277
Query: 538 TP-------PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 590
P + + +A +++ + + +L ++++ +L + + + +
Sbjct: 4278 DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELN 4337
Query: 591 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635
S + + WK+ + E+A A+++ ++ + W+D
Sbjct: 4338 SAWDSLNKAWKDRIDKLEEA------MQAAVQYQDGLQAVFDWVD 4376
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/361 (23%), Positives = 169/361 (46%), Gaps = 40/361 (11%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELESTTQAK 78
++++F AEL QN +++++ + +L++E P+ + R K L EI W EL T +
Sbjct: 2649 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2708
Query: 79 ARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVE 136
++L E+S Q A+L + L+ E + + P D +N+Q +++Q + ++
Sbjct: 2709 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL---LQ 2765
Query: 137 EWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER----RR 185
E+ + + TAA P E P+ + +V E+ AV ++ L L +R +
Sbjct: 2766 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2825
Query: 186 LLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
++ S + + L D+L+ + +L LA+ T A+ Q ++ Q +++EIQ
Sbjct: 2826 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMKQEIQQE 2881
Query: 244 GPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
++ + + E AL +AE + R LE + ++ + + AE Q L +A
Sbjct: 2882 KKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2940
Query: 301 QYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ-LEQGVENYEESIAQLSR 358
+ ++ + +AWL D K+EQ+ + L LE ++++++ L+
Sbjct: 2941 HQFQQMSRDFQAWL----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2990
Query: 359 Q 359
Q
Sbjct: 2991 Q 2991
Score = 54.3 bits (129), Expect = 4e-07
Identities = 124/668 (18%), Positives = 248/668 (37%), Gaps = 80/668 (11%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
H+ F L EK EG+ L+ + + A+++ +L I+ W + +
Sbjct: 2981 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 3040
Query: 81 QLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
+L E+ KA + + L + ++ L+++ D A + + KL+S++ ++++ +
Sbjct: 3041 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 3100
Query: 140 REVGELQAQTA--ALPLEPASKELVGERQNAVGERLVRLLEPLQERR----RLLLASKEL 193
V EL TA L + KE+V + ++ +++ + E L ++ + KE
Sbjct: 3101 GMV-ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEF 3159
Query: 194 HQVAHDLDDELAWVQERLP----LAMQTERGNGLQAVQQHIKKNQGLRREIQ-------- 241
+V+ + +L +E+L L Q L +Q K Q L+ ++
Sbjct: 3160 QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3219
Query: 242 -----AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296
+ +VL + +A S ++ V L++ G+ +++
Sbjct: 3220 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3279
Query: 297 FQVEQYYFDVAEV--------------EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQL 342
+ + +A V +A+L + E LM S D T +++ +
Sbjct: 3280 AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN---KTCKMMLATEET 3336
Query: 343 EQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQ 402
+ + + LS+QC LL+ EQ+ +++ Y LKE + L++
Sbjct: 3337 SPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS----ILLQK- 3391
Query: 403 YWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462
AE+ + P +G + E ++ F F E + +
Sbjct: 3392 -----------------AEEHEESQGP-VGMETETINQQLNMFKVFQKEEIEPLQGKQQD 3433
Query: 463 VNQMVDELIECGHTAAAT--MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 520
VN + LI+ + +T + D +N W L + + RA L + F DA
Sbjct: 3434 VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3493
Query: 521 ELQGQIEEKRRRLPRLTTPPEPR----PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576
E L PP + Q+ L+ D + V +++ E A
Sbjct: 3494 ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT 3553
Query: 577 LRTVYAGEHAEAIASREQEVL--QGWKELLSACEDARLHVSS-TADALRFHSQVRDLLSW 633
E A+ + +Q L W+ LL+ E + + A +FH + L W
Sbjct: 3554 -----TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3608
Query: 634 MDGIASQI 641
+ I ++
Sbjct: 3609 LTTIEKRL 3616
Score = 53.9 bits (128), Expect = 5e-07
Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%)
Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 362
V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A
Sbjct: 786 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 845
Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422
L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK
Sbjct: 846 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 896
Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482
E + + + +++ ++ +E E E + +V ++ ++L+ H A T+
Sbjct: 897 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 955
Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535
++ + W+ +L+L Q + + +FF+DA+E + + + R
Sbjct: 956 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 1008
Score = 52.0 bits (123), Expect = 2e-06
Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%)
Query: 48 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 107
Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + +
Sbjct: 603 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 656
Query: 108 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 153
+ V G + T + + + + + G Q+ T +L
Sbjct: 657 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 716
Query: 154 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ PA LV + V ++ L+ +Q R+ LL +S +
Sbjct: 717 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 776
Query: 197 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
+ + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E
Sbjct: 777 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 836
Query: 251 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
+ A L+ AE + R L+S +A L + +++ LD + +
Sbjct: 837 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 889
Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
WL E+E ++ D + + + H +L + ++ EE+I + LL HP
Sbjct: 890 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 949
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 414
I E R A++ Q+ W+ QL + V +
Sbjct: 950 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 977
Score = 49.7 bits (117), Expect = 9e-06
Identities = 128/682 (18%), Positives = 268/682 (39%), Gaps = 83/682 (12%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQAKA 79
+H ++ ++ +E + + G L++ E A++++ KL + Q W + T+ +
Sbjct: 4511 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4570
Query: 80 RQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VNSQLKKLQSMES 133
+QL A + A +L + L E L P G L +N ++ + E+
Sbjct: 4571 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4630
Query: 134 QVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKE 192
+ EE Y+ + +Q L P S E + + N + E+ + L ER+ L +
Sbjct: 4631 K-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4687
Query: 193 LHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
L H+ L D + W+ Q L + + L V I +++ E+ +H ++ E
Sbjct: 4688 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIE- 4746
Query: 251 LERAGA-----------------LASLRSPEAEAVRRGLE-------------QLQSAWA 280
L++ G L S++S + V+R +E Q AW+
Sbjct: 4747 LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4806
Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE----QELLMMSEDKGKDEQSTLQLL 336
L E E ++ LD+ ++ D +++ L + Q+ L T + L
Sbjct: 4807 KLMEWLEESEKSLDSELEIAN---DPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4863
Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396
K+ L ++ +++L + + + RQ++++ + + + +
Sbjct: 4864 KEKTSLADDNLKLDDMLSELRDKWDTI-------CGKSVERQNKLEEALLFSGQFTDALQ 4916
Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456
++ WLY++ Q +AE + V G D + V L + F E G
Sbjct: 4917 ALID---WLYRVEPQ-------LAEDQPVHG------DIDLVMNLIDNHKAFQKELGKR- 4959
Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKF 515
+ A+ + ELIE ++ + L+ W + L + + +L AA R+ +F
Sbjct: 4960 TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEF 5019
Query: 516 FSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575
S L + E + L P+ + ++ + F ++ L + +L +
Sbjct: 5020 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATT 5076
Query: 576 QLRTVYAGEHAEAIASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LL 631
TV A H ++I + + + ++E+L+ + + ++S L ++ + LL
Sbjct: 5077 MGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALL 5136
Query: 632 SWMDGIASQIGAADKPRCPSSL 653
+W+ + + DK P +
Sbjct: 5137 AWLQWAETTLTDKDKEVIPQEI 5158
Score = 46.2 bits (108), Expect = 1e-04
Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%)
Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 164
M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E
Sbjct: 796 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 853
Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224
+ + + + +LL + + R L LH +EL W+ E+ + +
Sbjct: 854 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 910
Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284
+ + + L RE+ ++ V E A L P + +Q+ W+ + +
Sbjct: 911 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 970
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 341
+ +Q + +++ D E +L + + S D+ L+++ ++
Sbjct: 971 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 1030
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 372
++ + Y+ +IA L + + ++++ +S+
Sbjct: 1031 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 1061
Score = 40.4 bits (93), Expect = 0.005
Identities = 85/454 (18%), Positives = 178/454 (39%), Gaps = 65/454 (14%)
Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95
L+++E E + L +EK E ++ Q W S T A + + + Q + S
Sbjct: 1603 LKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISKTLKDAEKAGKPPFSKQKISS- 1656
Query: 96 AELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQSMESQVEEWYR-----EVGELQ 146
E+ K + LQ + GD T + + +L+ ++E Y + +LQ
Sbjct: 1657 EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEKQVKTLQESYNLLFSESLKQLQ 1715
Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206
+ ++ K +V ERQ E+L + + L + L+ +E + D EL
Sbjct: 1716 ESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG-DGTVELKK 1773
Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----IQAHGPRLEEVLERAGALASLR 261
Q + +Q + QA+ + +K + +E Q +E+ L A
Sbjct: 1774 YQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1832
Query: 262 SPEAEAVRRGLEQLQS-----------AWAGLREAAERRQQVLDAAFQVEQ--------- 301
+ +AE ++ L+++ + A L E+ + + +LD V++
Sbjct: 1833 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1892
Query: 302 --------YYFDVAEVEAWLGEQE-----LLMMSEDK--GKDEQSTLQLLKKHLQLEQGV 346
+F + ++ +GE++ LL D G +++ Q +K + +
Sbjct: 1893 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKI 1952
Query: 347 ENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQVDRLY-VALKELGEERRVALE 400
+ +++ ++ + LLE + + E++ + ++ Y AL E ++ ++
Sbjct: 1953 ISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS 2012
Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD 434
Q L + +E EHW+ + E + E G D
Sbjct: 2013 LQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 2046
Score = 40.4 bits (93), Expect = 0.005
Identities = 145/722 (20%), Positives = 282/722 (39%), Gaps = 131/722 (18%)
Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 62
+D + L + R ++F ++ +K L I G +++ E A S K+ G
Sbjct: 2046 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 2101
Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 120
R+ +L+ T + R L+ SK + L + +L K H E + G AT
Sbjct: 2102 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2158
Query: 121 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 160
+ L + ++++ Q+EE G++ +Q A+ L PA +
Sbjct: 2159 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2218
Query: 161 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 218
+ + VG R L + + ER +L + V LD+ L W+ L Q +
Sbjct: 2219 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2277
Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 277
A+Q I KN L ++I + + E+ P A +++ ++ L +
Sbjct: 2278 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2337
Query: 278 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 328
++ EA+ + ++ L + +VE + +++ +L + + D GKD
Sbjct: 2338 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2394
Query: 329 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 369
++ST + L KKHL++ G+ + + E LS++ + + +
Sbjct: 2395 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2454
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
E ++ Q Q+D V +K L + W+ + +++V ++ G+
Sbjct: 2455 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2497
Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 487
+LG+ E LQEK+S E ++ N LI T A +A K G
Sbjct: 2498 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2552
Query: 488 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 541
LN E A E L + +++ H + L+ +I E +L +L E
Sbjct: 2553 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2612
Query: 542 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 575
P P+ + +T ++FE +L+ V++V++L++
Sbjct: 2613 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2672
Query: 576 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 632
+L + EA ++ E+ W+EL D + + +++ L +F + L
Sbjct: 2673 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2731
Query: 633 WM 634
W+
Sbjct: 2732 WL 2733
Score = 37.7 bits (86), Expect = 0.035
Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 83/465 (17%)
Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93
+W++++E +++ + +PE + ++ +L + + +E+E + SK D+ Q
Sbjct: 1482 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKMDE-CQ 1530
Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGELQAQTA 150
+AE + + +LQ + A V+SQ K K + M+S + +E +L+ +
Sbjct: 1531 KYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1586
Query: 151 ALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLDDELAW 206
AL L+ + G+ L RL E +E++ + +KEL + ++ L
Sbjct: 1587 AL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1640
Query: 207 VQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGALASLR 261
++ + P + Q + ++ + + Q ++ + HG ++ EE E + +L+
Sbjct: 1641 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1700
Query: 262 SPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYYFDVAE 308
L+QLQ + +E E+ Q + D Q E
Sbjct: 1701 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE-------- 1752
Query: 309 VEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ESIAQLS 357
+G QE M+ + + K QS + L+K +Q L + V+N E E+ +LS
Sbjct: 1753 -NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1811
Query: 358 RQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQYWLYQL 408
++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q L +
Sbjct: 1812 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ--LEES 1867
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 453
++ L W++ V S G +H V+++ + F G
Sbjct: 1868 KTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1908
Score = 35.4 bits (80), Expect = 0.17
Identities = 69/371 (18%), Positives = 144/371 (38%), Gaps = 57/371 (15%)
Query: 3 MARDGTRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 56
M DGT E +L K +AE+ +N E ++ G++L QE L
Sbjct: 1763 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL--- 1817
Query: 57 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 116
+ +KL E + +L + ++L D++V + + + + + QL++
Sbjct: 1818 IEQKLNEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE----- 1866
Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176
+ + L L +++ E + ++ Q E K +GE G L
Sbjct: 1867 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----L 1922
Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236
LE D+D ++ QE L Q + + + QH
Sbjct: 1923 LET-------------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH------- 1956
Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295
+ + + +LE+ G S E E +++ +++L+ + L E+ ++ +
Sbjct: 1957 -QAVIIATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 2013
Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354
++E++ D E E WL + E + + + G D+ + L LK+ + V +++ +
Sbjct: 2014 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 2073
Query: 355 QLSRQCRALLE 365
++ +LE
Sbjct: 2074 YITISGNRVLE 2084
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 97.1 bits (240), Expect = 5e-20
Identities = 136/675 (20%), Positives = 286/675 (42%), Gaps = 65/675 (9%)
Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 74
L ++ H+ +A++K ++K+ + G QL++ P S+++K +++++
Sbjct: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946
Query: 75 TQAKARQLFEA--------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ-- 124
+ +A L EA K DQ+++S + ++L S +V+ + + N
Sbjct: 3947 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVS 4006
Query: 125 --LKKLQ----SMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNA---VGERLVR 175
++KLQ +++ + EE G +A ++ ++V +N V ER +
Sbjct: 4007 VDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAK 4066
Query: 176 LLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228
LL+ ++ + L++ K+ DL+D G V+Q
Sbjct: 4067 LLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----------------GIDPSVVKQ 4110
Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAE 287
+ + +R EI L+ V+ L A+ P+ V++ +++L SAW L +A +
Sbjct: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK 4170
Query: 288 RRQQVLDAAFQVEQYYFD-VAEVEAW--LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344
R L+ A Q Y D + V W + +L MS G D ++ Q +++ Q +
Sbjct: 4171 DRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKS 4229
Query: 345 GVENYEESIAQLSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQ 402
+ + +L+ Q LL+ +S++ + ++ ++ +L+E R+ LE
Sbjct: 4230 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4289
Query: 403 YW-LYQLSRQVSELEHWIAEKE-VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460
L Q + EL W+ E +++ +G D + + + K ++ +A + +
Sbjct: 4290 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTV 4348
Query: 461 AAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAELLELMGTRAQLL-AASRELHKFFSD 518
AVN+ ++LIE A+ + K + LN+ W +LE R Q L A R+ F +
Sbjct: 4349 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGE 4408
Query: 519 ARELQGQIEEKRRRL----PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA 574
+LQ + + R L P P + + AFE + S +++ Q+
Sbjct: 4409 IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML 4468
Query: 575 AQLRTVYAGEHAEAIASRE-QEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLS 632
A+ + AE ++ + + W+ + + + + + + A+ FH+ ++D ++
Sbjct: 4469 AR-----CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4523
Query: 633 WMDGIASQIGAADKP 647
W+ + A +P
Sbjct: 4524 WLTQAEQTLNVASRP 4538
Score = 68.9 bits (167), Expect = 1e-11
Identities = 114/593 (19%), Positives = 241/593 (40%), Gaps = 63/593 (10%)
Query: 92 VQSFAELDKKLLHMESQLQDVDPGGD-LATVNSQLKKLQSMESQVEEWYREVGELQAQT- 149
+Q + M SQ + D D +A V + LQ + ++ + +++ L A
Sbjct: 3084 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3143
Query: 150 -------AALPLEPASKELVGERQN--AVGERLVRLLEPLQERRRLLLAS-KELHQVAHD 199
L E S +LVG +++ A+ ++ +LL+ Q R + + K L +
Sbjct: 3144 NANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3203
Query: 200 LDDELAWVQE-------RLPLAMQTERGNGLQAV-----QQHIKKNQGLRREIQAHGPRL 247
L + +Q+ + P+ M+TE N + ++ I+ QG ++++ G L
Sbjct: 3204 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3263
Query: 248 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQVEQYYFDV 306
+ ++ +S + + L+ + + W L ++ A+R Q+ +A ++ +
Sbjct: 3264 IQ--------SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3315
Query: 307 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESIAQLSRQCRA 362
+ +W+ + E L+ ++ K + +++K +Q L++ +++ + ++ + R+
Sbjct: 3316 ESLLSWMVDTEELVANQ---KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3372
Query: 363 LLEMGHP-DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE-LEHWIA 420
+ P D +I ++ S +D + AL E R LE + Q + E L W+
Sbjct: 3373 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3432
Query: 421 --EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
EK +V P Q S L+E+ ++ A + + N+ + + + G +
Sbjct: 3433 TIEKRLVNCEPIGTQ----ASKLEEQIAQHK-----ALEDDIINHNKHLHQAVSIGQSLK 3483
Query: 479 AT-------MAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFS-DARELQGQIEEK 529
M + K ++ W E+ E +R++LL + K F D EL + E
Sbjct: 3484 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEV 3543
Query: 530 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 589
+L +L+ Q LR + D+ L V Q +L G+ I
Sbjct: 3544 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3603
Query: 590 ASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLSWMDGIASQI 641
+ + + +K++ D + A R HS +L +W+D + ++
Sbjct: 3604 QDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3656
Score = 66.6 bits (161), Expect = 7e-11
Identities = 120/645 (18%), Positives = 256/645 (39%), Gaps = 51/645 (7%)
Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
LR Q L E L++ + ++Q+K E + K + ++ A+ A
Sbjct: 3576 LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3635
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
R+L S ++L +++ +LL E+Q+ + +LKK + +
Sbjct: 3636 RRLH--STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3693
Query: 140 REVGELQAQTAALPLEPASKELVGE---RQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
EV + +++V E R V + + + +E + +L S++ Q
Sbjct: 3694 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA---ILRSQQFDQA 3750
Query: 197 AHDLDDELAWVQE---RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253
A D EL+W+ E +L + Q ++K EI H ++++++
Sbjct: 3751 A---DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT--FTMEILRHKDIIDDLVKS 3805
Query: 254 AGALASLRSPEA-EAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVAEVEA 311
+ + S E +++++ L+++ + + + +ER Q+ A V Q++ E+
Sbjct: 3806 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3865
Query: 312 WLGEQELLMMSEDKGKDEQSTL-QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
WL E + ++ E TL Q ++H QL + + ++ I ++++ LLE+ +
Sbjct: 3866 WLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGE 3925
Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQ------------QYWLYQLSRQVSELEHW 418
I + D LY +KE ++R VAL++ L L R V L
Sbjct: 3926 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3985
Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
+ V E + ++VSV EK G E +A ++ +A
Sbjct: 3986 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI------SA 4039
Query: 479 ATMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537
+ + D + W + L+ R A+LL KF+ D L I++ + + L
Sbjct: 4040 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLE 4099
Query: 538 TP-------PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 590
P + + +A +++ + + +L ++++ +L + + + +
Sbjct: 4100 DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELN 4159
Query: 591 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635
S + + WK+ + E+A A+++ ++ + W+D
Sbjct: 4160 SAWDSLNKAWKDRIDKLEEA------MQAAVQYQDGLQAVFDWVD 4198
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/361 (23%), Positives = 169/361 (46%), Gaps = 40/361 (11%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELESTTQAK 78
++++F AEL QN +++++ + +L++E P+ + R K L EI W EL T +
Sbjct: 2471 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2530
Query: 79 ARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVE 136
++L E+S Q A+L + L+ E + + P D +N+Q +++Q + ++
Sbjct: 2531 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL---LQ 2587
Query: 137 EWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER----RR 185
E+ + + TAA P E P+ + +V E+ AV ++ L L +R +
Sbjct: 2588 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2647
Query: 186 LLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
++ S + + L D+L+ + +L LA+ T A+ Q ++ Q +++EIQ
Sbjct: 2648 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMKQEIQQE 2703
Query: 244 GPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
++ + + E AL +AE + R LE + ++ + + AE Q L +A
Sbjct: 2704 KKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2762
Query: 301 QYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ-LEQGVENYEESIAQLSR 358
+ ++ + +AWL D K+EQ+ + L LE ++++++ L+
Sbjct: 2763 HQFQQMSRDFQAWL----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2812
Query: 359 Q 359
Q
Sbjct: 2813 Q 2813
Score = 54.3 bits (129), Expect = 4e-07
Identities = 124/668 (18%), Positives = 248/668 (37%), Gaps = 80/668 (11%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
H+ F L EK EG+ L+ + + A+++ +L I+ W + +
Sbjct: 2803 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2862
Query: 81 QLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
+L E+ KA + + L + ++ L+++ D A + + KL+S++ ++++ +
Sbjct: 2863 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2922
Query: 140 REVGELQAQTA--ALPLEPASKELVGERQNAVGERLVRLLEPLQERR----RLLLASKEL 193
V EL TA L + KE+V + ++ +++ + E L ++ + KE
Sbjct: 2923 GMV-ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEF 2981
Query: 194 HQVAHDLDDELAWVQERLP----LAMQTERGNGLQAVQQHIKKNQGLRREIQ-------- 241
+V+ + +L +E+L L Q L +Q K Q L+ ++
Sbjct: 2982 QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3041
Query: 242 -----AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296
+ +VL + +A S ++ V L++ G+ +++
Sbjct: 3042 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3101
Query: 297 FQVEQYYFDVAEV--------------EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQL 342
+ + +A V +A+L + E LM S D T +++ +
Sbjct: 3102 AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN---KTCKMMLATEET 3158
Query: 343 EQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQ 402
+ + + LS+QC LL+ EQ+ +++ Y LKE + L++
Sbjct: 3159 SPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS----ILLQK- 3213
Query: 403 YWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462
AE+ + P +G + E ++ F F E + +
Sbjct: 3214 -----------------AEEHEESQGP-VGMETETINQQLNMFKVFQKEEIEPLQGKQQD 3255
Query: 463 VNQMVDELIECGHTAAAT--MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 520
VN + LI+ + +T + D +N W L + + RA L + F DA
Sbjct: 3256 VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3315
Query: 521 ELQGQIEEKRRRLPRLTTPPEPR----PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576
E L PP + Q+ L+ D + V +++ E A
Sbjct: 3316 ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT 3375
Query: 577 LRTVYAGEHAEAIASREQEVL--QGWKELLSACEDARLHVSS-TADALRFHSQVRDLLSW 633
E A+ + +Q L W+ LL+ E + + A +FH + L W
Sbjct: 3376 -----TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3430
Query: 634 MDGIASQI 641
+ I ++
Sbjct: 3431 LTTIEKRL 3438
Score = 53.9 bits (128), Expect = 5e-07
Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%)
Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 362
V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A
Sbjct: 608 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 667
Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422
L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK
Sbjct: 668 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 718
Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482
E + + + +++ ++ +E E E + +V ++ ++L+ H A T+
Sbjct: 719 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 777
Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535
++ + W+ +L+L Q + + +FF+DA+E + + + R
Sbjct: 778 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 830
Score = 52.0 bits (123), Expect = 2e-06
Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%)
Query: 48 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 107
Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + +
Sbjct: 425 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 478
Query: 108 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 153
+ V G + T + + + + + G Q+ T +L
Sbjct: 479 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 538
Query: 154 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ PA LV + V ++ L+ +Q R+ LL +S +
Sbjct: 539 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 598
Query: 197 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
+ + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E
Sbjct: 599 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 658
Query: 251 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
+ A L+ AE + R L+S +A L + +++ LD + +
Sbjct: 659 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 711
Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
WL E+E ++ D + + + H +L + ++ EE+I + LL HP
Sbjct: 712 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 771
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 414
I E R A++ Q+ W+ QL + V +
Sbjct: 772 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 799
Score = 49.7 bits (117), Expect = 9e-06
Identities = 128/682 (18%), Positives = 268/682 (39%), Gaps = 83/682 (12%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQAKA 79
+H ++ ++ +E + + G L++ E A++++ KL + Q W + T+ +
Sbjct: 4333 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4392
Query: 80 RQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VNSQLKKLQSMES 133
+QL A + A +L + L E L P G L +N ++ + E+
Sbjct: 4393 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4452
Query: 134 QVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKE 192
+ EE Y+ + +Q L P S E + + N + E+ + L ER+ L +
Sbjct: 4453 K-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4509
Query: 193 LHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
L H+ L D + W+ Q L + + L V I +++ E+ +H ++ E
Sbjct: 4510 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIE- 4568
Query: 251 LERAGA-----------------LASLRSPEAEAVRRGLE-------------QLQSAWA 280
L++ G L S++S + V+R +E Q AW+
Sbjct: 4569 LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4628
Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE----QELLMMSEDKGKDEQSTLQLL 336
L E E ++ LD+ ++ D +++ L + Q+ L T + L
Sbjct: 4629 KLMEWLEESEKSLDSELEIAN---DPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685
Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396
K+ L ++ +++L + + + RQ++++ + + + +
Sbjct: 4686 KEKTSLADDNLKLDDMLSELRDKWDTI-------CGKSVERQNKLEEALLFSGQFTDALQ 4738
Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456
++ WLY++ Q +AE + V G D + V L + F E G
Sbjct: 4739 ALID---WLYRVEPQ-------LAEDQPVHG------DIDLVMNLIDNHKAFQKELGKR- 4781
Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKF 515
+ A+ + ELIE ++ + L+ W + L + + +L AA R+ +F
Sbjct: 4782 TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEF 4841
Query: 516 FSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575
S L + E + L P+ + ++ + F ++ L + +L +
Sbjct: 4842 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATT 4898
Query: 576 QLRTVYAGEHAEAIASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LL 631
TV A H ++I + + + ++E+L+ + + ++S L ++ + LL
Sbjct: 4899 MGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALL 4958
Query: 632 SWMDGIASQIGAADKPRCPSSL 653
+W+ + + DK P +
Sbjct: 4959 AWLQWAETTLTDKDKEVIPQEI 4980
Score = 46.2 bits (108), Expect = 1e-04
Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%)
Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 164
M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E
Sbjct: 618 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 675
Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224
+ + + + +LL + + R L LH +EL W+ E+ + +
Sbjct: 676 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 732
Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284
+ + + L RE+ ++ V E A L P + +Q+ W+ + +
Sbjct: 733 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 792
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 341
+ +Q + +++ D E +L + + S D+ L+++ ++
Sbjct: 793 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 852
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 372
++ + Y+ +IA L + + ++++ +S+
Sbjct: 853 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 883
Score = 40.4 bits (93), Expect = 0.005
Identities = 85/454 (18%), Positives = 178/454 (39%), Gaps = 65/454 (14%)
Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95
L+++E E + L +EK E ++ Q W S T A + + + Q + S
Sbjct: 1425 LKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISKTLKDAEKAGKPPFSKQKISS- 1478
Query: 96 AELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQSMESQVEEWYR-----EVGELQ 146
E+ K + LQ + GD T + + +L+ ++E Y + +LQ
Sbjct: 1479 EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEKQVKTLQESYNLLFSESLKQLQ 1537
Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206
+ ++ K +V ERQ E+L + + L + L+ +E + D EL
Sbjct: 1538 ESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG-DGTVELKK 1595
Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----IQAHGPRLEEVLERAGALASLR 261
Q + +Q + QA+ + +K + +E Q +E+ L A
Sbjct: 1596 YQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1654
Query: 262 SPEAEAVRRGLEQLQS-----------AWAGLREAAERRQQVLDAAFQVEQ--------- 301
+ +AE ++ L+++ + A L E+ + + +LD V++
Sbjct: 1655 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1714
Query: 302 --------YYFDVAEVEAWLGEQE-----LLMMSEDK--GKDEQSTLQLLKKHLQLEQGV 346
+F + ++ +GE++ LL D G +++ Q +K + +
Sbjct: 1715 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKI 1774
Query: 347 ENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQVDRLY-VALKELGEERRVALE 400
+ +++ ++ + LLE + + E++ + ++ Y AL E ++ ++
Sbjct: 1775 ISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS 1834
Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD 434
Q L + +E EHW+ + E + E G D
Sbjct: 1835 LQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1868
Score = 40.4 bits (93), Expect = 0.005
Identities = 145/722 (20%), Positives = 282/722 (39%), Gaps = 131/722 (18%)
Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 62
+D + L + R ++F ++ +K L I G +++ E A S K+ G
Sbjct: 1868 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1923
Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 120
R+ +L+ T + R L+ SK + L + +L K H E + G AT
Sbjct: 1924 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1980
Query: 121 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 160
+ L + ++++ Q+EE G++ +Q A+ L PA +
Sbjct: 1981 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2040
Query: 161 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 218
+ + VG R L + + ER +L + V LD+ L W+ L Q +
Sbjct: 2041 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099
Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 277
A+Q I KN L ++I + + E+ P A +++ ++ L +
Sbjct: 2100 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2159
Query: 278 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 328
++ EA+ + ++ L + +VE + +++ +L + + D GKD
Sbjct: 2160 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2216
Query: 329 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 369
++ST + L KKHL++ G+ + + E LS++ + + +
Sbjct: 2217 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2276
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
E ++ Q Q+D V +K L + W+ + +++V ++ G+
Sbjct: 2277 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2319
Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 487
+LG+ E LQEK+S E ++ N LI T A +A K G
Sbjct: 2320 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2374
Query: 488 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 541
LN E A E L + +++ H + L+ +I E +L +L E
Sbjct: 2375 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2434
Query: 542 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 575
P P+ + +T ++FE +L+ V++V++L++
Sbjct: 2435 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2494
Query: 576 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 632
+L + EA ++ E+ W+EL D + + +++ L +F + L
Sbjct: 2495 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2553
Query: 633 WM 634
W+
Sbjct: 2554 WL 2555
Score = 37.7 bits (86), Expect = 0.035
Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 83/465 (17%)
Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93
+W++++E +++ + +PE + ++ +L + + +E+E + SK D+ Q
Sbjct: 1304 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKMDE-CQ 1352
Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGELQAQTA 150
+AE + + +LQ + A V+SQ K K + M+S + +E +L+ +
Sbjct: 1353 KYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1408
Query: 151 ALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLDDELAW 206
AL L+ + G+ L RL E +E++ + +KEL + ++ L
Sbjct: 1409 AL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1462
Query: 207 VQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGALASLR 261
++ + P + Q + ++ + + Q ++ + HG ++ EE E + +L+
Sbjct: 1463 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1522
Query: 262 SPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYYFDVAE 308
L+QLQ + +E E+ Q + D Q E
Sbjct: 1523 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE-------- 1574
Query: 309 VEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ESIAQLS 357
+G QE M+ + + K QS + L+K +Q L + V+N E E+ +LS
Sbjct: 1575 -NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1633
Query: 358 RQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQYWLYQL 408
++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q L +
Sbjct: 1634 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ--LEES 1689
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 453
++ L W++ V S G +H V+++ + F G
Sbjct: 1690 KTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1730
Score = 35.4 bits (80), Expect = 0.17
Identities = 69/371 (18%), Positives = 144/371 (38%), Gaps = 57/371 (15%)
Query: 3 MARDGTRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 56
M DGT E +L K +AE+ +N E ++ G++L QE L
Sbjct: 1585 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL--- 1639
Query: 57 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 116
+ +KL E + +L + ++L D++V + + + + + QL++
Sbjct: 1640 IEQKLNEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE----- 1688
Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176
+ + L L +++ E + ++ Q E K +GE G L
Sbjct: 1689 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----L 1744
Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236
LE D+D ++ QE L Q + + + QH
Sbjct: 1745 LET-------------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH------- 1778
Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295
+ + + +LE+ G S E E +++ +++L+ + L E+ ++ +
Sbjct: 1779 -QAVIIATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1835
Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354
++E++ D E E WL + E + + + G D+ + L LK+ + V +++ +
Sbjct: 1836 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1895
Query: 355 QLSRQCRALLE 365
++ +LE
Sbjct: 1896 YITISGNRVLE 1906
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 97.1 bits (240), Expect = 5e-20
Identities = 136/675 (20%), Positives = 286/675 (42%), Gaps = 65/675 (9%)
Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 74
L ++ H+ +A++K ++K+ + G QL++ P S+++K +++++
Sbjct: 3561 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3620
Query: 75 TQAKARQLFEA--------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ-- 124
+ +A L EA K DQ+++S + ++L S +V+ + + N
Sbjct: 3621 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVS 3680
Query: 125 --LKKLQ----SMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNA---VGERLVR 175
++KLQ +++ + EE G +A ++ ++V +N V ER +
Sbjct: 3681 VDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAK 3740
Query: 176 LLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228
LL+ ++ + L++ K+ DL+D G V+Q
Sbjct: 3741 LLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----------------GIDPSVVKQ 3784
Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAE 287
+ + +R EI L+ V+ L A+ P+ V++ +++L SAW L +A +
Sbjct: 3785 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK 3844
Query: 288 RRQQVLDAAFQVEQYYFD-VAEVEAW--LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344
R L+ A Q Y D + V W + +L MS G D ++ Q +++ Q +
Sbjct: 3845 DRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKS 3903
Query: 345 GVENYEESIAQLSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQ 402
+ + +L+ Q LL+ +S++ + ++ ++ +L+E R+ LE
Sbjct: 3904 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 3963
Query: 403 YW-LYQLSRQVSELEHWIAEKE-VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460
L Q + EL W+ E +++ +G D + + + K ++ +A + +
Sbjct: 3964 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTV 4022
Query: 461 AAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAELLELMGTRAQLL-AASRELHKFFSD 518
AVN+ ++LIE A+ + K + LN+ W +LE R Q L A R+ F +
Sbjct: 4023 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGE 4082
Query: 519 ARELQGQIEEKRRRL----PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA 574
+LQ + + R L P P + + AFE + S +++ Q+
Sbjct: 4083 IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML 4142
Query: 575 AQLRTVYAGEHAEAIASRE-QEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLS 632
A+ + AE ++ + + W+ + + + + + + A+ FH+ ++D ++
Sbjct: 4143 AR-----CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4197
Query: 633 WMDGIASQIGAADKP 647
W+ + A +P
Sbjct: 4198 WLTQAEQTLNVASRP 4212
Score = 68.9 bits (167), Expect = 1e-11
Identities = 114/593 (19%), Positives = 241/593 (40%), Gaps = 63/593 (10%)
Query: 92 VQSFAELDKKLLHMESQLQDVDPGGD-LATVNSQLKKLQSMESQVEEWYREVGELQAQT- 149
+Q + M SQ + D D +A V + LQ + ++ + +++ L A
Sbjct: 2758 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 2817
Query: 150 -------AALPLEPASKELVGERQN--AVGERLVRLLEPLQERRRLLLAS-KELHQVAHD 199
L E S +LVG +++ A+ ++ +LL+ Q R + + K L +
Sbjct: 2818 NANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 2877
Query: 200 LDDELAWVQE-------RLPLAMQTERGNGLQAV-----QQHIKKNQGLRREIQAHGPRL 247
L + +Q+ + P+ M+TE N + ++ I+ QG ++++ G L
Sbjct: 2878 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 2937
Query: 248 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQVEQYYFDV 306
+ ++ +S + + L+ + + W L ++ A+R Q+ +A ++ +
Sbjct: 2938 IQ--------SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 2989
Query: 307 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESIAQLSRQCRA 362
+ +W+ + E L+ ++ K + +++K +Q L++ +++ + ++ + R+
Sbjct: 2990 ESLLSWMVDTEELVANQ---KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3046
Query: 363 LLEMGHP-DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE-LEHWIA 420
+ P D +I ++ S +D + AL E R LE + Q + E L W+
Sbjct: 3047 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3106
Query: 421 --EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
EK +V P Q S L+E+ ++ A + + N+ + + + G +
Sbjct: 3107 TIEKRLVNCEPIGTQ----ASKLEEQIAQHK-----ALEDDIINHNKHLHQAVSIGQSLK 3157
Query: 479 AT-------MAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFS-DARELQGQIEEK 529
M + K ++ W E+ E +R++LL + K F D EL + E
Sbjct: 3158 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEV 3217
Query: 530 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 589
+L +L+ Q LR + D+ L V Q +L G+ I
Sbjct: 3218 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3277
Query: 590 ASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLSWMDGIASQI 641
+ + + +K++ D + A R HS +L +W+D + ++
Sbjct: 3278 QDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3330
Score = 66.6 bits (161), Expect = 7e-11
Identities = 120/645 (18%), Positives = 256/645 (39%), Gaps = 51/645 (7%)
Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
LR Q L E L++ + ++Q+K E + K + ++ A+ A
Sbjct: 3250 LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3309
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
R+L S ++L +++ +LL E+Q+ + +LKK + +
Sbjct: 3310 RRLH--STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3367
Query: 140 REVGELQAQTAALPLEPASKELVGE---RQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
EV + +++V E R V + + + +E + +L S++ Q
Sbjct: 3368 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA---ILRSQQFDQA 3424
Query: 197 AHDLDDELAWVQE---RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253
A D EL+W+ E +L + Q ++K EI H ++++++
Sbjct: 3425 A---DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT--FTMEILRHKDIIDDLVKS 3479
Query: 254 AGALASLRSPEA-EAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVAEVEA 311
+ + S E +++++ L+++ + + + +ER Q+ A V Q++ E+
Sbjct: 3480 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3539
Query: 312 WLGEQELLMMSEDKGKDEQSTL-QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
WL E + ++ E TL Q ++H QL + + ++ I ++++ LLE+ +
Sbjct: 3540 WLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGE 3599
Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQ------------QYWLYQLSRQVSELEHW 418
I + D LY +KE ++R VAL++ L L R V L
Sbjct: 3600 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3659
Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
+ V E + ++VSV EK G E +A ++ +A
Sbjct: 3660 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI------SA 3713
Query: 479 ATMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537
+ + D + W + L+ R A+LL KF+ D L I++ + + L
Sbjct: 3714 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLE 3773
Query: 538 TP-------PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 590
P + + +A +++ + + +L ++++ +L + + + +
Sbjct: 3774 DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELN 3833
Query: 591 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635
S + + WK+ + E+A A+++ ++ + W+D
Sbjct: 3834 SAWDSLNKAWKDRIDKLEEA------MQAAVQYQDGLQAVFDWVD 3872
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/361 (23%), Positives = 169/361 (46%), Gaps = 40/361 (11%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELESTTQAK 78
++++F AEL QN +++++ + +L++E P+ + R K L EI W EL T +
Sbjct: 2145 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2204
Query: 79 ARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVE 136
++L E+S Q A+L + L+ E + + P D +N+Q +++Q + ++
Sbjct: 2205 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL---LQ 2261
Query: 137 EWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER----RR 185
E+ + + TAA P E P+ + +V E+ AV ++ L L +R +
Sbjct: 2262 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2321
Query: 186 LLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
++ S + + L D+L+ + +L LA+ T A+ Q ++ Q +++EIQ
Sbjct: 2322 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMKQEIQQE 2377
Query: 244 GPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
++ + + E AL +AE + R LE + ++ + + AE Q L +A
Sbjct: 2378 KKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2436
Query: 301 QYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ-LEQGVENYEESIAQLSR 358
+ ++ + +AWL D K+EQ+ + L LE ++++++ L+
Sbjct: 2437 HQFQQMSRDFQAWL----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2486
Query: 359 Q 359
Q
Sbjct: 2487 Q 2487
Score = 54.3 bits (129), Expect = 4e-07
Identities = 124/668 (18%), Positives = 248/668 (37%), Gaps = 80/668 (11%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
H+ F L EK EG+ L+ + + A+++ +L I+ W + +
Sbjct: 2477 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2536
Query: 81 QLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
+L E+ KA + + L + ++ L+++ D A + + KL+S++ ++++ +
Sbjct: 2537 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2596
Query: 140 REVGELQAQTA--ALPLEPASKELVGERQNAVGERLVRLLEPLQERR----RLLLASKEL 193
V EL TA L + KE+V + ++ +++ + E L ++ + KE
Sbjct: 2597 GMV-ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEF 2655
Query: 194 HQVAHDLDDELAWVQERLP----LAMQTERGNGLQAVQQHIKKNQGLRREIQ-------- 241
+V+ + +L +E+L L Q L +Q K Q L+ ++
Sbjct: 2656 QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 2715
Query: 242 -----AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296
+ +VL + +A S ++ V L++ G+ +++
Sbjct: 2716 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 2775
Query: 297 FQVEQYYFDVAEV--------------EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQL 342
+ + +A V +A+L + E LM S D T +++ +
Sbjct: 2776 AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN---KTCKMMLATEET 2832
Query: 343 EQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQ 402
+ + + LS+QC LL+ EQ+ +++ Y LKE + L++
Sbjct: 2833 SPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS----ILLQK- 2887
Query: 403 YWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462
AE+ + P +G + E ++ F F E + +
Sbjct: 2888 -----------------AEEHEESQGP-VGMETETINQQLNMFKVFQKEEIEPLQGKQQD 2929
Query: 463 VNQMVDELIECGHTAAAT--MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 520
VN + LI+ + +T + D +N W L + + RA L + F DA
Sbjct: 2930 VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 2989
Query: 521 ELQGQIEEKRRRLPRLTTPPEPR----PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576
E L PP + Q+ L+ D + V +++ E A
Sbjct: 2990 ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT 3049
Query: 577 LRTVYAGEHAEAIASREQEVL--QGWKELLSACEDARLHVSS-TADALRFHSQVRDLLSW 633
E A+ + +Q L W+ LL+ E + + A +FH + L W
Sbjct: 3050 -----TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3104
Query: 634 MDGIASQI 641
+ I ++
Sbjct: 3105 LTTIEKRL 3112
Score = 53.9 bits (128), Expect = 5e-07
Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%)
Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 362
V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A
Sbjct: 282 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 341
Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422
L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK
Sbjct: 342 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 392
Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482
E + + + +++ ++ +E E E + +V ++ ++L+ H A T+
Sbjct: 393 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 451
Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535
++ + W+ +L+L Q + + +FF+DA+E + + + R
Sbjct: 452 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 504
Score = 52.0 bits (123), Expect = 2e-06
Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%)
Query: 48 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 107
Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + +
Sbjct: 99 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 152
Query: 108 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 153
+ V G + T + + + + + G Q+ T +L
Sbjct: 153 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 212
Query: 154 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ PA LV + V ++ L+ +Q R+ LL +S +
Sbjct: 213 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 272
Query: 197 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
+ + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E
Sbjct: 273 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 332
Query: 251 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
+ A L+ AE + R L+S +A L + +++ LD + +
Sbjct: 333 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 385
Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369
WL E+E ++ D + + + H +L + ++ EE+I + LL HP
Sbjct: 386 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 445
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 414
I E R A++ Q+ W+ QL + V +
Sbjct: 446 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 473
Score = 49.7 bits (117), Expect = 9e-06
Identities = 128/682 (18%), Positives = 268/682 (39%), Gaps = 83/682 (12%)
Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQAKA 79
+H ++ ++ +E + + G L++ E A++++ KL + Q W + T+ +
Sbjct: 4007 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4066
Query: 80 RQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VNSQLKKLQSMES 133
+QL A + A +L + L E L P G L +N ++ + E+
Sbjct: 4067 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4126
Query: 134 QVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKE 192
+ EE Y+ + +Q L P S E + + N + E+ + L ER+ L +
Sbjct: 4127 K-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4183
Query: 193 LHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
L H+ L D + W+ Q L + + L V I +++ E+ +H ++ E
Sbjct: 4184 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIE- 4242
Query: 251 LERAGA-----------------LASLRSPEAEAVRRGLE-------------QLQSAWA 280
L++ G L S++S + V+R +E Q AW+
Sbjct: 4243 LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4302
Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE----QELLMMSEDKGKDEQSTLQLL 336
L E E ++ LD+ ++ D +++ L + Q+ L T + L
Sbjct: 4303 KLMEWLEESEKSLDSELEIAN---DPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4359
Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396
K+ L ++ +++L + + + RQ++++ + + + +
Sbjct: 4360 KEKTSLADDNLKLDDMLSELRDKWDTI-------CGKSVERQNKLEEALLFSGQFTDALQ 4412
Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456
++ WLY++ Q +AE + V G D + V L + F E G
Sbjct: 4413 ALID---WLYRVEPQ-------LAEDQPVHG------DIDLVMNLIDNHKAFQKELGKR- 4455
Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKF 515
+ A+ + ELIE ++ + L+ W + L + + +L AA R+ +F
Sbjct: 4456 TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEF 4515
Query: 516 FSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575
S L + E + L P+ + ++ + F ++ L + +L +
Sbjct: 4516 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATT 4572
Query: 576 QLRTVYAGEHAEAIASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LL 631
TV A H ++I + + + ++E+L+ + + ++S L ++ + LL
Sbjct: 4573 MGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALL 4632
Query: 632 SWMDGIASQIGAADKPRCPSSL 653
+W+ + + DK P +
Sbjct: 4633 AWLQWAETTLTDKDKEVIPQEI 4654
Score = 46.2 bits (108), Expect = 1e-04
Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%)
Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 164
M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E
Sbjct: 292 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 349
Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224
+ + + + +LL + + R L LH +EL W+ E+ + +
Sbjct: 350 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 406
Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284
+ + + L RE+ ++ V E A L P + +Q+ W+ + +
Sbjct: 407 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 466
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 341
+ +Q + +++ D E +L + + S D+ L+++ ++
Sbjct: 467 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 372
++ + Y+ +IA L + + ++++ +S+
Sbjct: 527 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 557
Score = 40.4 bits (93), Expect = 0.005
Identities = 85/454 (18%), Positives = 178/454 (39%), Gaps = 65/454 (14%)
Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95
L+++E E + L +EK E ++ Q W S T A + + + Q + S
Sbjct: 1099 LKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISKTLKDAEKAGKPPFSKQKISS- 1152
Query: 96 AELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQSMESQVEEWYR-----EVGELQ 146
E+ K + LQ + GD T + + +L+ ++E Y + +LQ
Sbjct: 1153 EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEKQVKTLQESYNLLFSESLKQLQ 1211
Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206
+ ++ K +V ERQ E+L + + L + L+ +E + D EL
Sbjct: 1212 ESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG-DGTVELKK 1269
Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----IQAHGPRLEEVLERAGALASLR 261
Q + +Q + QA+ + +K + +E Q +E+ L A
Sbjct: 1270 YQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1328
Query: 262 SPEAEAVRRGLEQLQS-----------AWAGLREAAERRQQVLDAAFQVEQ--------- 301
+ +AE ++ L+++ + A L E+ + + +LD V++
Sbjct: 1329 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1388
Query: 302 --------YYFDVAEVEAWLGEQE-----LLMMSEDK--GKDEQSTLQLLKKHLQLEQGV 346
+F + ++ +GE++ LL D G +++ Q +K + +
Sbjct: 1389 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKI 1448
Query: 347 ENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQVDRLY-VALKELGEERRVALE 400
+ +++ ++ + LLE + + E++ + ++ Y AL E ++ ++
Sbjct: 1449 ISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS 1508
Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD 434
Q L + +E EHW+ + E + E G D
Sbjct: 1509 LQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1542
Score = 40.4 bits (93), Expect = 0.005
Identities = 145/722 (20%), Positives = 282/722 (39%), Gaps = 131/722 (18%)
Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 62
+D + L + R ++F ++ +K L I G +++ E A S K+ G
Sbjct: 1542 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1597
Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 120
R+ +L+ T + R L+ SK + L + +L K H E + G AT
Sbjct: 1598 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1654
Query: 121 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 160
+ L + ++++ Q+EE G++ +Q A+ L PA +
Sbjct: 1655 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 1714
Query: 161 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 218
+ + VG R L + + ER +L + V LD+ L W+ L Q +
Sbjct: 1715 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 1773
Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 277
A+Q I KN L ++I + + E+ P A +++ ++ L +
Sbjct: 1774 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 1833
Query: 278 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 328
++ EA+ + ++ L + +VE + +++ +L + + D GKD
Sbjct: 1834 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 1890
Query: 329 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 369
++ST + L KKHL++ G+ + + E LS++ + + +
Sbjct: 1891 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 1950
Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429
E ++ Q Q+D V +K L + W+ + +++V ++ G+
Sbjct: 1951 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 1993
Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 487
+LG+ E LQEK+S E ++ N LI T A +A K G
Sbjct: 1994 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2048
Query: 488 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 541
LN E A E L + +++ H + L+ +I E +L +L E
Sbjct: 2049 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2108
Query: 542 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 575
P P+ + +T ++FE +L+ V++V++L++
Sbjct: 2109 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2168
Query: 576 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 632
+L + EA ++ E+ W+EL D + + +++ L +F + L
Sbjct: 2169 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2227
Query: 633 WM 634
W+
Sbjct: 2228 WL 2229
Score = 37.7 bits (86), Expect = 0.035
Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 83/465 (17%)
Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93
+W++++E +++ + +PE + ++ +L + + +E+E + SK D+ Q
Sbjct: 978 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKMDE-CQ 1026
Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGELQAQTA 150
+AE + + +LQ + A V+SQ K K + M+S + +E +L+ +
Sbjct: 1027 KYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1082
Query: 151 ALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLDDELAW 206
AL L+ + G+ L RL E +E++ + +KEL + ++ L
Sbjct: 1083 AL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1136
Query: 207 VQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGALASLR 261
++ + P + Q + ++ + + Q ++ + HG ++ EE E + +L+
Sbjct: 1137 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1196
Query: 262 SPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYYFDVAE 308
L+QLQ + +E E+ Q + D Q E
Sbjct: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE-------- 1248
Query: 309 VEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ESIAQLS 357
+G QE M+ + + K QS + L+K +Q L + V+N E E+ +LS
Sbjct: 1249 -NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1307
Query: 358 RQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQYWLYQL 408
++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q L +
Sbjct: 1308 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ--LEES 1363
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 453
++ L W++ V S G +H V+++ + F G
Sbjct: 1364 KTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1404
Score = 35.4 bits (80), Expect = 0.17
Identities = 69/371 (18%), Positives = 144/371 (38%), Gaps = 57/371 (15%)
Query: 3 MARDGTRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 56
M DGT E +L K +AE+ +N E ++ G++L QE L
Sbjct: 1259 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL--- 1313
Query: 57 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 116
+ +KL E + +L + ++L D++V + + + + + QL++
Sbjct: 1314 IEQKLNEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE----- 1362
Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176
+ + L L +++ E + ++ Q E K +GE G L
Sbjct: 1363 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----L 1418
Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236
LE D+D ++ QE L Q + + + QH
Sbjct: 1419 LET-------------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH------- 1452
Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295
+ + + +LE+ G S E E +++ +++L+ + L E+ ++ +
Sbjct: 1453 -QAVIIATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1509
Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354
++E++ D E E WL + E + + + G D+ + L LK+ + V +++ +
Sbjct: 1510 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1569
Query: 355 QLSRQCRALLE 365
++ +LE
Sbjct: 1570 YITISGNRVLE 1580
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 84.0 bits (206), Expect = 4e-16
Identities = 139/688 (20%), Positives = 282/688 (40%), Gaps = 87/688 (12%)
Query: 25 FMAELAQNKEWLEKIER---EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81
F +L Q+++ ++ + + E Q+ ++E+ + A+S +++L E R+ L T Q ++
Sbjct: 2725 FALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRK----LVRTFQKWLKE 2780
Query: 82 LFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYRE 141
+ + S EL+K++ H++S L D G L ++++ + +E E
Sbjct: 2781 TEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL------VEEINCKGTSLENLIME 2834
Query: 142 VGELQAQTAALPLEPASKELVGERQ------------------NAVGERLVRLLEPLQER 183
+ +Q + P+ VG N E+L +L QE
Sbjct: 2835 ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQES 2894
Query: 184 RRLLL-ASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQA 242
+ +L +E+H+ A+ + L +E L + V+ + N+ E++
Sbjct: 2895 LQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQ 2954
Query: 243 HGPRLEEVLER-AGALASL-RSPEAEAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQV 299
+ P++++V E AG L + S EAE ++ E+L S W E RQ Q+ ++A +
Sbjct: 2955 NSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHL 3014
Query: 300 EQYYFDVAEVEAWLGEQELLM-----MSEDK---GKDEQSTLQLLK-------KHLQLEQ 344
+ +++ WL E+EL+M +S D +Q +LK +H QL +
Sbjct: 3015 ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
Query: 345 -------GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRV 397
G + S +Q+ ++ +++ + +++++ R SQ+D+ V
Sbjct: 3075 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK---------- 3124
Query: 398 ALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE-LGQDFEHVSVLQEKFSEFASETGMAG 456
+ + Q L LS +V + ++ + ++ PE + Q E S ++ + E A
Sbjct: 3125 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQ 3184
Query: 457 R-----ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511
L + DEL + T A + +D + L + + Q E
Sbjct: 3185 TLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDE 3244
Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571
L + D + Q + +L RL + + Q++L +++V+
Sbjct: 3245 LRTWLDDKQSQQAKNCPISAKLERLQSQLQEN---EEFQKSLNQHSGSYEVIVA------ 3295
Query: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDL 630
EG + L +V GE + ++ E+ W+EL D + + A ++ V DL
Sbjct: 3296 EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDL 3355
Query: 631 LSWMDGIASQIG----AADKPRCPSSLL 654
+ W++ +++ D + SSLL
Sbjct: 3356 VPWIEDCKAKMSELRVTLDPVQLESSLL 3383
Score = 81.3 bits (199), Expect = 3e-15
Identities = 128/683 (18%), Positives = 272/683 (39%), Gaps = 69/683 (10%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70
D+ +L ++ + +A++K ++K+ + G QL + PE V +K + +A+
Sbjct: 4356 DHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ 4415
Query: 71 LESTTQAKARQLFEA-SKADQLVQSFAELDKKLLHME---SQLQ-------DVDPGGDLA 119
++ + +A L EA S++ Q+ + +++ L +E S+L+ +VD +
Sbjct: 4416 IKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECI 4475
Query: 120 TVN-SQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAV--------- 169
+ N S +L+ ++ E R EL ++ + A+KE+ + V
Sbjct: 4476 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4535
Query: 170 -GERLVRLLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGN 221
ER ++ L+ L+ + LL K+ + HDL+ G
Sbjct: 4536 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP----------------GI 4579
Query: 222 GLQAVQQHIKKNQGLRREIQAHGPRLEEV-LERAGALASLRSPEAEAVRRGLEQLQSAWA 280
++Q ++ + ++ E LE + + A + + E VR+ ++++ +AW
Sbjct: 4580 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4639
Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQEL-LMMSEDKGKDEQSTLQLLKK 338
L + + R + L+ A Q Y D + + WL + L G D + L +
Sbjct: 4640 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4699
Query: 339 HLQLEQGVENYEESIAQLSRQCRALLEMG--HPDSEQISRRQSQVDRLYVALKELGEERR 396
+ + V + + +L+ Q +L+ D + I +++ L+ L E R+
Sbjct: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
Query: 397 VALEQQYW-LYQLSRQVSELEHWIAE-KEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454
LE L Q + EL W+ +E++ + D + + V K ++ +
Sbjct: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV-L 4818
Query: 455 AGRERLAAVNQMVDELIE-CGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELH 513
A + + VN+ +EL+E A+++ + +N+ W +L+ R Q +L
Sbjct: 4819 AHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ------QLQ 4872
Query: 514 KFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEG 573
A+ +IE+ L R+ + + T R L SQ++ +E
Sbjct: 4873 STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEET 4932
Query: 574 AAQL----RTVYAGEHAEAIASREQEVL----QGWKELLSACEDARLHVSSTAD-ALRFH 624
QL R + S+ ++ + Q W + S E+ + + + A F
Sbjct: 4933 YNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQ 4992
Query: 625 SQVRDLLSWMDGIASQIGAADKP 647
+ +++ ++W+ + A P
Sbjct: 4993 NSLQEFINWLTLAEQSLNIASPP 5015
Score = 80.9 bits (198), Expect = 4e-15
Identities = 134/656 (20%), Positives = 277/656 (42%), Gaps = 54/656 (8%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKP--ELAASVRKKLGEIRQCWAELESTTQAKA 79
++AF+AEL QN ++K++ L+ P + A + +K E+ W T A+
Sbjct: 2945 NKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQ 3004
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQ-------DVDPGGDLATVNSQLKKLQSME 132
RQL E++ Q+ AE + ME +L +DP +N+Q +++Q M
Sbjct: 3005 RQLEESASHLACFQA-AESQLRPWLMEKELMMGVLGPLSIDPN----MLNAQKQQVQFML 3059
Query: 133 SQVEEWYREVGELQAQTAALPLEPASKEL----VGERQNAVGERLVRLLEPLQERR---- 184
+ E ++ +L + P L V + ++ ++ V L + L R
Sbjct: 3060 KEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQID 3119
Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244
+ ++ S + ++ DL +++ V +R L++Q+ +AV+Q +++ +R +++
Sbjct: 3120 QAIVKSTQYQELLQDLSEKVRAVGQR--LSVQSAISTQPEAVKQQLEETSEIRSDLEQLD 3177
Query: 245 PRLEEVLERAGALASLRSPE--AEAVRRGLEQLQSAWAGLRE-AAERRQQVLDAAFQVEQ 301
++E L+ L + + +++ LE + GL + AA+R ++ A +Q
Sbjct: 3178 HEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 3237
Query: 302 YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCR 361
+ E+ WL +++ + K+ + +L + QL++ E +++S+ Q S
Sbjct: 3238 FQQMFDELRTWLDDKQ-----SQQAKNCPISAKLERLQSQLQEN-EEFQKSLNQHSGSYE 3291
Query: 362 ALLEMGH------PDSEQISRRQSQVDRLYVALKELGE---ERRVALE---QQYWLYQLS 409
++ G P E+ Q+Q+ L +EL + +R+ L+ Q+ YQ
Sbjct: 3292 VIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW- 3350
Query: 410 RQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAV-NQMVD 468
V +L WI ++ A EL + V + A + R L + N D
Sbjct: 3351 -HVEDLVPWI--EDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 3407
Query: 469 ELIECGHTAAATMAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527
LI + + K G+N+ A EL L ++ L +F + ++ ++E
Sbjct: 3408 ILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVE 3467
Query: 528 EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL-RTVYAGEHA 586
+ +L S ++++ LRA + LQ L QV L+ L G A
Sbjct: 3468 GAKHQLEIFDALGSQACSNKNLEK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDA 3526
Query: 587 EAIASREQEVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLSWMDGIASQI 641
+ + + Q + E+ + + + + + +FH +VR++ S + + ++
Sbjct: 3527 SQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDEL 3582
Score = 69.3 bits (168), Expect = 1e-11
Identities = 132/666 (19%), Positives = 268/666 (40%), Gaps = 50/666 (7%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70
D +L LR +A + E+ + + LE + L+ +R + I Q
Sbjct: 3374 DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDA 3433
Query: 71 LESTTQAKARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 129
+ QAK L E + + + +SF ++KK+ + QL+ D G A N L+KL+
Sbjct: 3434 VTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLR 3493
Query: 130 SMESQVEEWYREVGELQAQTAAL---------------PLEPASKELVGERQNAVGERLV 174
+ + ++ +V L+ T L E A +E + +Q V V
Sbjct: 3494 AQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQR-VNSGCV 3552
Query: 175 RLLEPLQERRRLLLASKELHQVAHDLDDELAWVQE--RLPLAMQTERGNGLQAVQQHIKK 232
+ L+ + +E+ DLDDEL + R ++Q++ ++ V+ + K
Sbjct: 3553 MMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ----IEDVRLFLNK 3608
Query: 233 NQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQV 292
L+ +I+A +LE G L L ++R LE L L E + RQ+
Sbjct: 3609 IHVLKLDIEASEAECRHMLEEEGTLDLL------GLKRELEALNKQCGKLTERGKARQEQ 3662
Query: 293 LDAAF-QVEQYYFDVAEV-EAWLGEQELLMMSEDKGKDEQSTLQLLK--KHLQLEQGVEN 348
L+ +VE +Y + + +A +E + G + + Q L K Q EQ V+
Sbjct: 3663 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQ-VDP 3721
Query: 349 YEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLY 406
+ + Q++ + L++ D + + + ++ + L ++ +R+A Q+ L+
Sbjct: 3722 LQMKLQQVNGLGQGLIQSAGKDCD-VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3780
Query: 407 --QLSRQVSELEHWIAE-KEVVAGSPELGQDFEHV--SVLQEKFSEFASETGMAGRERLA 461
+ + L W+A+ +E++A +++ V + ++K + + A + L
Sbjct: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
Query: 462 AVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARE 521
A + + E T + L W ELL R + L L K F + E
Sbjct: 3841 AEGGRIAQSAELADREKIT--GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAE 3898
Query: 522 -LQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR--AFEHDLQLLVSQVRQLQEGAAQLR 578
+ + ++L + P +A Q+ +R A E D++ + V Q + L
Sbjct: 3899 PISDFLSVTEKKL--ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLS 3956
Query: 579 TVYAGEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTADALRFHSQVRDLLSWMDGI 637
++ + ++ + + + E+ C A L + ++A F ++L+W+ +
Sbjct: 3957 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEV 4016
Query: 638 ASQIGA 643
++ +
Sbjct: 4017 EDKLSS 4022
Score = 63.2 bits (152), Expect = 8e-10
Identities = 81/401 (20%), Positives = 171/401 (42%), Gaps = 18/401 (4%)
Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELES 73
LH++ H A E+ K+ +++ + GQ L+ Q E +++KL I+ +A++
Sbjct: 4033 LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITV 4092
Query: 74 TTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSME 132
T+ R L +A + A + ++ EL L +E +L G + Q+ + Q +
Sbjct: 4093 TSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA---TSGGQSPTGEQIPQFQQRQ 4149
Query: 133 SQVEEWYREVGEL-----QAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQER-RR 185
++++ E + + A L L P ++E + + + E+ + + + +R
Sbjct: 4150 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 4209
Query: 186 LLLASKELHQVAHDLDDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
+ A + Q D ELAWV E R +A+ R Q Q ++ + +I H
Sbjct: 4210 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ-LQVQKAFSIDIIRH 4268
Query: 244 GPRLEEVLERAGALASLRSPEAEAV-RRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQ 301
++E+ + E + V + E L + + +ER ++ A V Q
Sbjct: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
Query: 302 YYFDVAEVEAWLGE-QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
++ E+ W+ E + L+ D + Q ++ QL + + ++ I +L +
Sbjct: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 4388
Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401
L E+ + E + + + + +Y +KE +R +AL++
Sbjct: 4389 PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDE 4429
Score = 57.0 bits (136), Expect = 6e-08
Identities = 103/558 (18%), Positives = 227/558 (40%), Gaps = 54/558 (9%)
Query: 39 IEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFE-ASKADQLVQSFAE 97
+++ G L E+ ++ +++KLGE+++ ++ + ++A+ +Q+ + + +Q E
Sbjct: 2272 LDQHGHNLTPEEQQM---LQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 2328
Query: 98 LDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA----LP 153
+ L E +L+++ GG L K Q S E+ G+L+ T + L
Sbjct: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS--EDVISHKGDLRFVTISGQKVLD 2386
Query: 154 LEPASKELVGERQNAVGERLVRLLEPLQER------------RRLLLASKELHQVAHDLD 201
+E + KE G+ + +G + L+ ER L + + HQ + D
Sbjct: 2387 MENSFKE--GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSAD 2444
Query: 202 DELAWVQ---ERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258
AW+Q + + + +Q+ + + L+ E+ H +E++ + A +
Sbjct: 2445 SLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIM 2504
Query: 259 SLR---SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF-QVEQYYFDVAEVEAWLG 314
+ +P+ V+ + + S + L + R +L A Q + + + +G
Sbjct: 2505 EIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIG 2564
Query: 315 EQELLMMSEDKGKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373
E E + + +Q L +++L+Q + + S+ +E +
Sbjct: 2565 EVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA 2624
Query: 374 ISR-RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVS-ELEHWIAEK-EVVAGSPE 430
+ + + ++V + + L +E+ +L++ ++ +S +L+ ++ K ++A +
Sbjct: 2625 VLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ 2684
Query: 431 LGQDFEH-VSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489
QD H +QE E + +E L + +V EL CG A + + +D +
Sbjct: 2685 PDQDITHFFQQIQELNLEMEDQ-----QENLDTLEHLVTELSSCGF--ALDLCQHQDRVQ 2737
Query: 490 EAWAELLELMGT----RAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS 545
+ EL T + +L +F R Q ++E +P P E S
Sbjct: 2738 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIP----PTETSMS 2793
Query: 546 ASSMQRTLRAFEHDLQLL 563
A +++ + EH LL
Sbjct: 2794 AKELEKQI---EHLKSLL 2808
Score = 47.8 bits (112), Expect = 3e-05
Identities = 91/492 (18%), Positives = 193/492 (39%), Gaps = 20/492 (4%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVR--KKLGEIRQCWAELESTTQAKA 79
H ++L +E ++ +G+ ++ + + + + + + + Q W + S + +
Sbjct: 4919 HMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4978
Query: 80 RQLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGG-DLATVNSQLKKLQSMESQVEE 137
+L EA + A + S E L E L P L TV SQ+++ + ++V
Sbjct: 4979 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 5038
Query: 138 WYREVGELQAQTAALPLEPASKE--LVGERQNAVGERLVRLLEPLQERRRLL----LASK 191
++ EL L ++ L+ +V R ++++ ER R L +K
Sbjct: 5039 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 5098
Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVL 251
+ H+ L D L + L + E N ++ + K++ ++ + P + +
Sbjct: 5099 QFHEAWKKLIDWLEDAESHLD--SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 5156
Query: 252 ERAGALA--SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
AL +L +++ + L +++ W + + RQ L+ A + D +
Sbjct: 5157 RTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQA 5216
Query: 310 EA-WLGEQELLMMSEDKGK--DEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEM 366
WL + E ++ED+ D + L+ H ++ + ++ L R R L+E
Sbjct: 5217 LVDWLYKVEP-QLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN 5275
Query: 367 GHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQ-VSELEHWIAEKE-V 424
D+ + + ++ + + +L ++ LEQ ++ R V L W++E E
Sbjct: 5276 SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQT 5335
Query: 425 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEW 484
+ L D E + L + EF + + +AV L C T+ W
Sbjct: 5336 LRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 5395
Query: 485 KDGLNEAWAELL 496
+ + E+L
Sbjct: 5396 ITIIRARFEEVL 5407
Score = 32.3 bits (72), Expect = 1.5
Identities = 71/395 (17%), Positives = 154/395 (38%), Gaps = 58/395 (14%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK--PELAASVRKKLGEIRQCW 68
D K+ + +H+ F L + + R G+ L ++ PE + + LGE+R W
Sbjct: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 5186
Query: 69 AELESTTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK 127
+ + + +L EA + Q + + L L +E QL + P V+ L
Sbjct: 5187 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQP------VHGDLDL 5240
Query: 128 LQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE--------- 178
+ ++ + + +E+G+ L + + +EL+ ++ +L E
Sbjct: 5241 VMNLMDAHKVFQKELGKRTGTVQVL--KRSGRELIENSRDDTTWVKGQLQELSTRWDTVC 5298
Query: 179 --PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL-----QAVQQHIK 231
+ ++ RL A K+ + L W+ E A QT R G +A+Q I
Sbjct: 5299 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSE----AEQTLRFRGALPDDTEALQSLID 5354
Query: 232 KNQGLRREIQAHGPRLEEVLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQ 290
++ ++++ + + + ++ P+ ++ + +++ + + A++ Q
Sbjct: 5355 THKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQ 5414
Query: 291 QVLDAAFQVEQYYFDVAE-VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349
Q L+ A ++ E + AW+ E ++ D
Sbjct: 5415 QRLETALSELVANAELLEELLAWIQWAETTLIQRD------------------------- 5449
Query: 350 EESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 384
+E I Q + +AL+ E+++R+Q VDR+
Sbjct: 5450 QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 5484
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 84.0 bits (206), Expect = 4e-16
Identities = 139/688 (20%), Positives = 282/688 (40%), Gaps = 87/688 (12%)
Query: 25 FMAELAQNKEWLEKIER---EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81
F +L Q+++ ++ + + E Q+ ++E+ + A+S +++L E R+ L T Q ++
Sbjct: 2223 FALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRK----LVRTFQKWLKE 2278
Query: 82 LFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYRE 141
+ + S EL+K++ H++S L D G L ++++ + +E E
Sbjct: 2279 TEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL------VEEINCKGTSLENLIME 2332
Query: 142 VGELQAQTAALPLEPASKELVGERQ------------------NAVGERLVRLLEPLQER 183
+ +Q + P+ VG N E+L +L QE
Sbjct: 2333 ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQES 2392
Query: 184 RRLLL-ASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQA 242
+ +L +E+H+ A+ + L +E L + V+ + N+ E++
Sbjct: 2393 LQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQ 2452
Query: 243 HGPRLEEVLER-AGALASL-RSPEAEAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQV 299
+ P++++V E AG L + S EAE ++ E+L S W E RQ Q+ ++A +
Sbjct: 2453 NSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHL 2512
Query: 300 EQYYFDVAEVEAWLGEQELLM-----MSEDK---GKDEQSTLQLLK-------KHLQLEQ 344
+ +++ WL E+EL+M +S D +Q +LK +H QL +
Sbjct: 2513 ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 2572
Query: 345 -------GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRV 397
G + S +Q+ ++ +++ + +++++ R SQ+D+ V
Sbjct: 2573 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK---------- 2622
Query: 398 ALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE-LGQDFEHVSVLQEKFSEFASETGMAG 456
+ + Q L LS +V + ++ + ++ PE + Q E S ++ + E A
Sbjct: 2623 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQ 2682
Query: 457 R-----ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511
L + DEL + T A + +D + L + + Q E
Sbjct: 2683 TLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDE 2742
Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571
L + D + Q + +L RL + + Q++L +++V+
Sbjct: 2743 LRTWLDDKQSQQAKNCPISAKLERLQSQLQEN---EEFQKSLNQHSGSYEVIVA------ 2793
Query: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDL 630
EG + L +V GE + ++ E+ W+EL D + + A ++ V DL
Sbjct: 2794 EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDL 2853
Query: 631 LSWMDGIASQIG----AADKPRCPSSLL 654
+ W++ +++ D + SSLL
Sbjct: 2854 VPWIEDCKAKMSELRVTLDPVQLESSLL 2881
Score = 81.3 bits (199), Expect = 3e-15
Identities = 128/683 (18%), Positives = 272/683 (39%), Gaps = 69/683 (10%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70
D+ +L ++ + +A++K ++K+ + G QL + PE V +K + +A+
Sbjct: 3854 DHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ 3913
Query: 71 LESTTQAKARQLFEA-SKADQLVQSFAELDKKLLHME---SQLQ-------DVDPGGDLA 119
++ + +A L EA S++ Q+ + +++ L +E S+L+ +VD +
Sbjct: 3914 IKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECI 3973
Query: 120 TVN-SQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAV--------- 169
+ N S +L+ ++ E R EL ++ + A+KE+ + V
Sbjct: 3974 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4033
Query: 170 -GERLVRLLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGN 221
ER ++ L+ L+ + LL K+ + HDL+ G
Sbjct: 4034 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP----------------GI 4077
Query: 222 GLQAVQQHIKKNQGLRREIQAHGPRLEEV-LERAGALASLRSPEAEAVRRGLEQLQSAWA 280
++Q ++ + ++ E LE + + A + + E VR+ ++++ +AW
Sbjct: 4078 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4137
Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQEL-LMMSEDKGKDEQSTLQLLKK 338
L + + R + L+ A Q Y D + + WL + L G D + L +
Sbjct: 4138 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4197
Query: 339 HLQLEQGVENYEESIAQLSRQCRALLEMG--HPDSEQISRRQSQVDRLYVALKELGEERR 396
+ + V + + +L+ Q +L+ D + I +++ L+ L E R+
Sbjct: 4198 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4257
Query: 397 VALEQQYW-LYQLSRQVSELEHWIAE-KEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454
LE L Q + EL W+ +E++ + D + + V K ++ +
Sbjct: 4258 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV-L 4316
Query: 455 AGRERLAAVNQMVDELIE-CGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELH 513
A + + VN+ +EL+E A+++ + +N+ W +L+ R Q +L
Sbjct: 4317 AHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ------QLQ 4370
Query: 514 KFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEG 573
A+ +IE+ L R+ + + T R L SQ++ +E
Sbjct: 4371 STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEET 4430
Query: 574 AAQL----RTVYAGEHAEAIASREQEVL----QGWKELLSACEDARLHVSSTAD-ALRFH 624
QL R + S+ ++ + Q W + S E+ + + + A F
Sbjct: 4431 YNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQ 4490
Query: 625 SQVRDLLSWMDGIASQIGAADKP 647
+ +++ ++W+ + A P
Sbjct: 4491 NSLQEFINWLTLAEQSLNIASPP 4513
Score = 80.9 bits (198), Expect = 4e-15
Identities = 134/656 (20%), Positives = 277/656 (42%), Gaps = 54/656 (8%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKP--ELAASVRKKLGEIRQCWAELESTTQAKA 79
++AF+AEL QN ++K++ L+ P + A + +K E+ W T A+
Sbjct: 2443 NKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQ 2502
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQ-------DVDPGGDLATVNSQLKKLQSME 132
RQL E++ Q+ AE + ME +L +DP +N+Q +++Q M
Sbjct: 2503 RQLEESASHLACFQA-AESQLRPWLMEKELMMGVLGPLSIDPN----MLNAQKQQVQFML 2557
Query: 133 SQVEEWYREVGELQAQTAALPLEPASKEL----VGERQNAVGERLVRLLEPLQERR---- 184
+ E ++ +L + P L V + ++ ++ V L + L R
Sbjct: 2558 KEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQID 2617
Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244
+ ++ S + ++ DL +++ V +R L++Q+ +AV+Q +++ +R +++
Sbjct: 2618 QAIVKSTQYQELLQDLSEKVRAVGQR--LSVQSAISTQPEAVKQQLEETSEIRSDLEQLD 2675
Query: 245 PRLEEVLERAGALASLRSPE--AEAVRRGLEQLQSAWAGLRE-AAERRQQVLDAAFQVEQ 301
++E L+ L + + +++ LE + GL + AA+R ++ A +Q
Sbjct: 2676 HEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 2735
Query: 302 YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCR 361
+ E+ WL +++ + K+ + +L + QL++ E +++S+ Q S
Sbjct: 2736 FQQMFDELRTWLDDKQ-----SQQAKNCPISAKLERLQSQLQEN-EEFQKSLNQHSGSYE 2789
Query: 362 ALLEMGH------PDSEQISRRQSQVDRLYVALKELGE---ERRVALE---QQYWLYQLS 409
++ G P E+ Q+Q+ L +EL + +R+ L+ Q+ YQ
Sbjct: 2790 VIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW- 2848
Query: 410 RQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAV-NQMVD 468
V +L WI ++ A EL + V + A + R L + N D
Sbjct: 2849 -HVEDLVPWI--EDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 2905
Query: 469 ELIECGHTAAATMAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527
LI + + K G+N+ A EL L ++ L +F + ++ ++E
Sbjct: 2906 ILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVE 2965
Query: 528 EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL-RTVYAGEHA 586
+ +L S ++++ LRA + LQ L QV L+ L G A
Sbjct: 2966 GAKHQLEIFDALGSQACSNKNLEK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDA 3024
Query: 587 EAIASREQEVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLSWMDGIASQI 641
+ + + Q + E+ + + + + + +FH +VR++ S + + ++
Sbjct: 3025 SQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDEL 3080
Score = 69.3 bits (168), Expect = 1e-11
Identities = 132/666 (19%), Positives = 268/666 (40%), Gaps = 50/666 (7%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70
D +L LR +A + E+ + + LE + L+ +R + I Q
Sbjct: 2872 DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDA 2931
Query: 71 LESTTQAKARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 129
+ QAK L E + + + +SF ++KK+ + QL+ D G A N L+KL+
Sbjct: 2932 VTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLR 2991
Query: 130 SMESQVEEWYREVGELQAQTAAL---------------PLEPASKELVGERQNAVGERLV 174
+ + ++ +V L+ T L E A +E + +Q V V
Sbjct: 2992 AQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQR-VNSGCV 3050
Query: 175 RLLEPLQERRRLLLASKELHQVAHDLDDELAWVQE--RLPLAMQTERGNGLQAVQQHIKK 232
+ L+ + +E+ DLDDEL + R ++Q++ ++ V+ + K
Sbjct: 3051 MMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ----IEDVRLFLNK 3106
Query: 233 NQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQV 292
L+ +I+A +LE G L L ++R LE L L E + RQ+
Sbjct: 3107 IHVLKLDIEASEAECRHMLEEEGTLDLL------GLKRELEALNKQCGKLTERGKARQEQ 3160
Query: 293 LDAAF-QVEQYYFDVAEV-EAWLGEQELLMMSEDKGKDEQSTLQLLK--KHLQLEQGVEN 348
L+ +VE +Y + + +A +E + G + + Q L K Q EQ V+
Sbjct: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQ-VDP 3219
Query: 349 YEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLY 406
+ + Q++ + L++ D + + + ++ + L ++ +R+A Q+ L+
Sbjct: 3220 LQMKLQQVNGLGQGLIQSAGKDCD-VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3278
Query: 407 --QLSRQVSELEHWIAE-KEVVAGSPELGQDFEHV--SVLQEKFSEFASETGMAGRERLA 461
+ + L W+A+ +E++A +++ V + ++K + + A + L
Sbjct: 3279 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3338
Query: 462 AVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARE 521
A + + E T + L W ELL R + L L K F + E
Sbjct: 3339 AEGGRIAQSAELADREKIT--GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAE 3396
Query: 522 -LQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR--AFEHDLQLLVSQVRQLQEGAAQLR 578
+ + ++L + P +A Q+ +R A E D++ + V Q + L
Sbjct: 3397 PISDFLSVTEKKL--ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLS 3454
Query: 579 TVYAGEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTADALRFHSQVRDLLSWMDGI 637
++ + ++ + + + E+ C A L + ++A F ++L+W+ +
Sbjct: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEV 3514
Query: 638 ASQIGA 643
++ +
Sbjct: 3515 EDKLSS 3520
Score = 63.2 bits (152), Expect = 8e-10
Identities = 81/401 (20%), Positives = 171/401 (42%), Gaps = 18/401 (4%)
Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELES 73
LH++ H A E+ K+ +++ + GQ L+ Q E +++KL I+ +A++
Sbjct: 3531 LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITV 3590
Query: 74 TTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSME 132
T+ R L +A + A + ++ EL L +E +L G + Q+ + Q +
Sbjct: 3591 TSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA---TSGGQSPTGEQIPQFQQRQ 3647
Query: 133 SQVEEWYREVGEL-----QAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQER-RR 185
++++ E + + A L L P ++E + + + E+ + + + +R
Sbjct: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707
Query: 186 LLLASKELHQVAHDLDDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243
+ A + Q D ELAWV E R +A+ R Q Q ++ + +I H
Sbjct: 3708 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ-LQVQKAFSIDIIRH 3766
Query: 244 GPRLEEVLERAGALASLRSPEAEAV-RRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQ 301
++E+ + E + V + E L + + +ER ++ A V Q
Sbjct: 3767 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 3826
Query: 302 YYFDVAEVEAWLGE-QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
++ E+ W+ E + L+ D + Q ++ QL + + ++ I +L +
Sbjct: 3827 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 3886
Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401
L E+ + E + + + + +Y +KE +R +AL++
Sbjct: 3887 PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDE 3927
Score = 57.0 bits (136), Expect = 6e-08
Identities = 103/558 (18%), Positives = 227/558 (40%), Gaps = 54/558 (9%)
Query: 39 IEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFE-ASKADQLVQSFAE 97
+++ G L E+ ++ +++KLGE+++ ++ + ++A+ +Q+ + + +Q E
Sbjct: 1770 LDQHGHNLTPEEQQM---LQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 1826
Query: 98 LDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA----LP 153
+ L E +L+++ GG L K Q S E+ G+L+ T + L
Sbjct: 1827 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS--EDVISHKGDLRFVTISGQKVLD 1884
Query: 154 LEPASKELVGERQNAVGERLVRLLEPLQER------------RRLLLASKELHQVAHDLD 201
+E + KE G+ + +G + L+ ER L + + HQ + D
Sbjct: 1885 MENSFKE--GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSAD 1942
Query: 202 DELAWVQ---ERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258
AW+Q + + + +Q+ + + L+ E+ H +E++ + A +
Sbjct: 1943 SLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIM 2002
Query: 259 SLR---SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF-QVEQYYFDVAEVEAWLG 314
+ +P+ V+ + + S + L + R +L A Q + + + +G
Sbjct: 2003 EIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIG 2062
Query: 315 EQELLMMSEDKGKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373
E E + + +Q L +++L+Q + + S+ +E +
Sbjct: 2063 EVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA 2122
Query: 374 ISR-RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVS-ELEHWIAEK-EVVAGSPE 430
+ + + ++V + + L +E+ +L++ ++ +S +L+ ++ K ++A +
Sbjct: 2123 VLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ 2182
Query: 431 LGQDFEH-VSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489
QD H +QE E + +E L + +V EL CG A + + +D +
Sbjct: 2183 PDQDITHFFQQIQELNLEMEDQ-----QENLDTLEHLVTELSSCGF--ALDLCQHQDRVQ 2235
Query: 490 EAWAELLELMGT----RAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS 545
+ EL T + +L +F R Q ++E +P P E S
Sbjct: 2236 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIP----PTETSMS 2291
Query: 546 ASSMQRTLRAFEHDLQLL 563
A +++ + EH LL
Sbjct: 2292 AKELEKQI---EHLKSLL 2306
Score = 47.8 bits (112), Expect = 3e-05
Identities = 91/492 (18%), Positives = 193/492 (39%), Gaps = 20/492 (4%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVR--KKLGEIRQCWAELESTTQAKA 79
H ++L +E ++ +G+ ++ + + + + + + + Q W + S + +
Sbjct: 4417 HMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4476
Query: 80 RQLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGG-DLATVNSQLKKLQSMESQVEE 137
+L EA + A + S E L E L P L TV SQ+++ + ++V
Sbjct: 4477 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 4536
Query: 138 WYREVGELQAQTAALPLEPASKE--LVGERQNAVGERLVRLLEPLQERRRLL----LASK 191
++ EL L ++ L+ +V R ++++ ER R L +K
Sbjct: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596
Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVL 251
+ H+ L D L + L + E N ++ + K++ ++ + P + +
Sbjct: 4597 QFHEAWKKLIDWLEDAESHLD--SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 4654
Query: 252 ERAGALA--SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309
AL +L +++ + L +++ W + + RQ L+ A + D +
Sbjct: 4655 RTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQA 4714
Query: 310 EA-WLGEQELLMMSEDKGK--DEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEM 366
WL + E ++ED+ D + L+ H ++ + ++ L R R L+E
Sbjct: 4715 LVDWLYKVEP-QLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN 4773
Query: 367 GHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQ-VSELEHWIAEKE-V 424
D+ + + ++ + + +L ++ LEQ ++ R V L W++E E
Sbjct: 4774 SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQT 4833
Query: 425 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEW 484
+ L D E + L + EF + + +AV L C T+ W
Sbjct: 4834 LRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 4893
Query: 485 KDGLNEAWAELL 496
+ + E+L
Sbjct: 4894 ITIIRARFEEVL 4905
Score = 46.2 bits (108), Expect = 1e-04
Identities = 122/600 (20%), Positives = 227/600 (37%), Gaps = 119/600 (19%)
Query: 3 MARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG 62
M + G ED+ L ++ + A AE+ +N+ L++ ++ QQ + V+
Sbjct: 1300 MMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQ-------YSTIVKDYEL 1352
Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKK---LLHMESQLQDVDPGGDLA 119
++ A +ES ++ ++ S +D + Q F +L + L+ + +Q +
Sbjct: 1353 QLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQ--------HVK 1404
Query: 120 TVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEP 179
++ L++L+ E VEE E+Q V E++ LL
Sbjct: 1405 YISDALRRLEEEEKVVEE--------------------------EKQEHV-EKVKELLGW 1437
Query: 180 LQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE 239
+ R + D E A +++++ + E + V + IK +Q
Sbjct: 1438 VSTLARNTQGKATSSETKESTDIEKAILEQQV---LSEELTTKKEQVSEAIKTSQIF--- 1491
Query: 240 IQAHGPRLEE-----VLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 294
+ HG +L E + E+ AL + L+QLQS A E ++Q
Sbjct: 1492 LAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNT 1551
Query: 295 AAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH----LQLEQGVEN-- 348
Q+E ++ +W+G+ E + +G+ Q L L+K+ L+ ++N
Sbjct: 1552 CHQQLE-------DLCSWVGQAERALAGH-QGRTTQQDLSALQKNQSDLKDLQDDIQNRA 1603
Query: 349 -------------YEESIAQLS-RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394
EE+ +LS R+ AL E H EQ Q + VA KEL E
Sbjct: 1604 TSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEET---RVAQKELEEA 1660
Query: 395 RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454
AL+Q E E + EL ++ + + L + + S G
Sbjct: 1661 VTSALQQ-------------------ETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 1701
Query: 455 AGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAEL---LELMGTRAQLLAASRE 511
L + Q+ +E G A + G+N+A +L E+M R Q L + ++
Sbjct: 1702 L-LTNLPGMEQLSGASLEKG---ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQ 1757
Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571
F + Q +++ L TP E + + + L ++++Q+Q
Sbjct: 1758 --NFILATQSAQAFLDQHGHNL----TPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQ 1811
Score = 45.8 bits (107), Expect = 1e-04
Identities = 91/428 (21%), Positives = 168/428 (39%), Gaps = 66/428 (15%)
Query: 163 GERQNAVGERLVRLLEPLQERRRLLLASKE----LHQVAHDLDDELAWVQERLPLAMQT- 217
G N V E +L+ + ER + L + E L Q+A+ + + +E+L LA T
Sbjct: 395 GYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTL 454
Query: 218 -------ERGNGLQA---VQQHIKKNQGLRREIQA--------HGPRLEEV--------- 250
E G +Q V +I++ +GL R++Q + +LEE+
Sbjct: 455 QADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQD 514
Query: 251 -----------LERAGALASLRSP----------EAEAVRRGLEQLQSAWAGLREAAERR 289
L R G SL +AE + + ++W R+ R
Sbjct: 515 ELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSW--FRKPMTRA 572
Query: 290 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349
+ V ++ + E V E+ +W+ E ++ + + G D S L+ + VE
Sbjct: 573 ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL 632
Query: 350 EESIAQLSRQCRALLEMGHPD-SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQL 408
S+ + + + H +E + + ++Q Y LKE R L+ + +
Sbjct: 633 GSSVKEARLYEGKMSQNFHTSYAETLGKLETQ----YCKLKETSSFRMRHLQSLHKF--V 686
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468
SR +EL W+ EKE + + + ++S + FSE E + ++ + Q
Sbjct: 687 SRATAELI-WLNEKEEEELAYDWSDNNSNISAKRNYFSELTME--LEEKQDVFRSLQDTA 743
Query: 469 ELIEC-GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527
EL+ H A T+ + + + +L Q + + +FFSDAREL+ +
Sbjct: 744 ELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLR 803
Query: 528 EKRRRLPR 535
+ + R
Sbjct: 804 NLQDSIKR 811
Score = 32.3 bits (72), Expect = 1.5
Identities = 41/211 (19%), Positives = 82/211 (38%), Gaps = 9/211 (4%)
Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP--LEPASKELV 162
M+ +L+ + G DL +V QL+ Q + + VEE V E + + + E +
Sbjct: 599 MQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETL 658
Query: 163 GERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG 222
G+ + + +L E R R L + LH+ EL W+ E+ + + +
Sbjct: 659 GKLET----QYCKLKETSSFRMRHL---QSLHKFVSRATAELIWLNEKEEEELAYDWSDN 711
Query: 223 LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL 282
+ L E++ + + A L+ P + V +QS +
Sbjct: 712 NSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWM 771
Query: 283 REAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313
++ +Q + Q++ D E+E++L
Sbjct: 772 KQLCLCVEQHVKENTAYFQFFSDARELESFL 802
Score = 32.3 bits (72), Expect = 1.5
Identities = 71/395 (17%), Positives = 154/395 (38%), Gaps = 58/395 (14%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK--PELAASVRKKLGEIRQCW 68
D K+ + +H+ F L + + R G+ L ++ PE + + LGE+R W
Sbjct: 4625 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 4684
Query: 69 AELESTTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK 127
+ + + +L EA + Q + + L L +E QL + P V+ L
Sbjct: 4685 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQP------VHGDLDL 4738
Query: 128 LQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE--------- 178
+ ++ + + +E+G+ L + + +EL+ ++ +L E
Sbjct: 4739 VMNLMDAHKVFQKELGKRTGTVQVL--KRSGRELIENSRDDTTWVKGQLQELSTRWDTVC 4796
Query: 179 --PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL-----QAVQQHIK 231
+ ++ RL A K+ + L W+ E A QT R G +A+Q I
Sbjct: 4797 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSE----AEQTLRFRGALPDDTEALQSLID 4852
Query: 232 KNQGLRREIQAHGPRLEEVLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQ 290
++ ++++ + + + ++ P+ ++ + +++ + + A++ Q
Sbjct: 4853 THKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQ 4912
Query: 291 QVLDAAFQVEQYYFDVAE-VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349
Q L+ A ++ E + AW+ E ++ D
Sbjct: 4913 QRLETALSELVANAELLEELLAWIQWAETTLIQRD------------------------- 4947
Query: 350 EESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 384
+E I Q + +AL+ E+++R+Q VDR+
Sbjct: 4948 QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 77.8 bits (190), Expect = 3e-14
Identities = 119/622 (19%), Positives = 260/622 (41%), Gaps = 68/622 (10%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
EL + + L+ +ER ++ ++ + ++RK W E+ + R LF+
Sbjct: 1320 ELRKLESTLDGLERSRER---QERRIQVTLRK--------WERFETNKETVVRYLFQTGS 1368
Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147
+ + SF+ L+ + S+L+ K+ +S+ Q E +E E+
Sbjct: 1369 SHERFLSFSSLES----LSSELEQTKEFS---------KRTESIAVQAENLVKEASEI-- 1413
Query: 148 QTAALPLEPASKELVGERQNAVGERLVRLLEPLQER-RRLLLASKELHQVAHDLDDELAW 206
PL P +K+L+ ++ ++ E++ +L + L+E + + + + + + W
Sbjct: 1414 -----PLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVW 1468
Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS-LRSPEA 265
+ E+ E + A+ I + + +EI++ + + E A + A + + E+
Sbjct: 1469 ITEKEKELNALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGES 1526
Query: 266 EAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQVEQYYFDVAEVEAWLGE-QELLMMSE 323
++ L Q++ LRE A+ + +L Q +++ ++ +++ + E ++ L +
Sbjct: 1527 ARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPI 1586
Query: 324 DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383
T ++L++H+ L Q +E+ +I S R ++ E + +Q D
Sbjct: 1587 KICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDI 1646
Query: 384 LYVALKELGEERRVALEQ--QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSV- 440
L A +ER+ ALE +W +L +++S W+ E A SPE+ + V V
Sbjct: 1647 LRRA-----KERQTALENLLAHW-QRLEKELSSFLTWLERGEAKASSPEMDISADRVKVE 1700
Query: 441 -----LQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAE 494
+Q +E S+ + + Q+ + L M + + L+E W +
Sbjct: 1701 GELQLIQALQNEVVSQASFYSK-----LLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1755
Query: 495 LLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR 554
L +++ R L + H+ F + L + L L T E S M +
Sbjct: 1756 LPQIINKRINFLQSVVAEHQQFDEL--LLSFSVWIKLFLSELQTTSE----ISIMDHQVA 1809
Query: 555 AFEH-----DLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609
H +++ +++ LQ A+L ++ E + + ++ Q ++E E
Sbjct: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVER 1869
Query: 610 ARLHVSSTADALRFHSQVRDLL 631
+L +S A+ L+ H+ + +L
Sbjct: 1870 RQLALSHLAEFLQSHASLSGIL 1891
Score = 53.1 bits (126), Expect = 8e-07
Identities = 110/554 (19%), Positives = 219/554 (39%), Gaps = 76/554 (13%)
Query: 48 QEKPELAASVRKKLGEIRQCWAEL-ESTTQAKARQLFEASKADQLVQSFAELDKKLLHME 106
QE ++ + ++L +++ +++ E T A+ + S A L S L + +H+E
Sbjct: 4710 QEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLE 4769
Query: 107 SQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQ 166
+DP + Q++ W GEL+ T+A +GE
Sbjct: 4770 DLAPHLDP-----------LAYEKARHQIQSWQ---GELKLLTSA----------IGETV 4805
Query: 167 NAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAV 226
R+V+ ++ E R L D L V+ L + + LQ +
Sbjct: 4806 TECESRMVQSIDFQTEMSRSL--------------DWLRRVKAELSGPVYLDLN--LQDI 4849
Query: 227 QQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE--AEAVRRGLEQLQSAWAGLRE 284
Q+ I+K Q + E+Q+ R+ L ++ E + + L +L ++E
Sbjct: 4850 QEEIRKIQIHQEEVQS-SLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4908
Query: 285 AAERRQQVLDAAF-QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLE 343
A RQ L + Q ++YY WL + + L+ G D +S + LK H++
Sbjct: 4909 ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFF 4968
Query: 344 QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEER--RVALEQ 401
+ + ++ +L L + P ++ ++ VA EL +R R + Q
Sbjct: 4969 STEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQK-------VASLELRSQRMSRDSGAQ 5021
Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL--------QEKFSEFASETG 453
L + + Q + + A +EV+ + + S+L +EK SE +
Sbjct: 5022 VDLLQRCTAQWHDYQK--AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5079
Query: 454 MAG--RERLAAVNQMVDELIECGHTAA-ATMAEWKDGLNEAWAELLELMGTRAQLLA-AS 509
+ E++ A+ + +L + G+ A+ AT++ + + W L + + ++L A
Sbjct: 5080 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5139
Query: 510 RELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDL---QLLVSQ 566
E F + ++ I++ + +LP + + ++ F +L Q +
Sbjct: 5140 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5199
Query: 567 VRQ-----LQEGAA 575
+RQ LQ+GAA
Sbjct: 5200 LRQQTLSMLQDGAA 5213
Score = 50.4 bits (119), Expect = 5e-06
Identities = 113/572 (19%), Positives = 238/572 (41%), Gaps = 52/572 (9%)
Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95
L +++ Q+ +++ +L + KK+G++ + + T + +L + ++A ++ +
Sbjct: 5405 LMELDAAVQKFLEQNGQLGKPLAKKIGKLTELH---QQTIRQAENRLSKLNQAASHLEEY 5461
Query: 96 AELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-GELQAQTAALPL 154
E+ + +L + + + G SQL++ + + E +E+ EL+A T L
Sbjct: 5462 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKL-- 5519
Query: 155 EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL---DDELAWVQERL 211
+ + E+ + L R E L++ ++ L + L A D+ + EL +Q L
Sbjct: 5520 QYLTSVYCTEKMSQQVAELGRETEELRQMIKIRL--QNLQDAAKDMKKFEAELKKLQAAL 5577
Query: 212 PLAMQTERGN--GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR 269
A T G ++++ + Q L E+++ P+++ V AL R PE
Sbjct: 5578 EQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSAL---RIPEDVVAS 5634
Query: 270 RGL----EQLQSAWAGLREAAERRQQVLDAAF-QVEQYYFDVAEVEAWL--GEQELLMMS 322
L +LQ + L+ A ++ ++ AA Q EQY ++ ++ + +E+
Sbjct: 5635 LPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI---- 5690
Query: 323 EDKGKDEQSTLQL---LKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 379
EDK + +L + +H +L Q ++ Y+E IA L+ +C+ L + ++ +
Sbjct: 5691 EDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLT--VT 5748
Query: 380 QVDRLYVALKELGEE--------RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPEL 431
+V+ L ++L E V + + L V+E ++ P
Sbjct: 5749 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC 5808
Query: 432 GQDF----EHVSVLQE--KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485
SV Q+ + ++E ++ E E G +AT A+
Sbjct: 5809 RSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT-AKLG 5867
Query: 486 DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLP-RLTTPPEPRP 544
D L +W L ++ + + L + E + + D+ + I K + +L+ PEP
Sbjct: 5868 D-LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ---SISTKMEAIELKLSESPEPGR 5923
Query: 545 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576
S S +A ++ +L ++ +LQ A+
Sbjct: 5924 SPESQMAEHQALMDEILMLQDEINELQSSLAE 5955
Score = 50.1 bits (118), Expect = 7e-06
Identities = 121/574 (21%), Positives = 226/574 (39%), Gaps = 79/574 (13%)
Query: 50 KPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ-SFAELDKKLLHMESQ 108
+P L S KLG++++ W L++ K R L+EA + Q Q S + K+ +E +
Sbjct: 5855 EPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELK 5914
Query: 109 L-QDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQN 167
L + +PG + SQ+ + Q++ ++ E+ ELQ+ A L S E Q
Sbjct: 5915 LSESPEPG---RSPESQMAEHQALMDEILMLQDEINELQSSLAE-ELVSESCEADPAEQL 5970
Query: 168 AVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG----- 222
A+ L L E + R + AS + + L+D+L ++R A+Q R
Sbjct: 5971 ALQSTLTVLAERMSTIR--MKASGKRQLLEEKLNDQLE--EQRQEQALQRYRCEADELDS 6026
Query: 223 --------LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL-------------- 260
L K+ + ++ L E+ ++ AL+ L
Sbjct: 6027 WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAH 6086
Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQVEQYYFDVAEVEAWLGEQELL 319
EAE + L +L+ + L+ A +Q + A + E+ D+ ++ G QE L
Sbjct: 6087 TKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWL 6145
Query: 320 MMSEDK-GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQ 378
+ + QS+LQ K +LEQ + + + ++ + +L + H +E
Sbjct: 6146 AQARTTWTQQRQSSLQQQK---ELEQELAEQKSLLRSVASRGEEIL-IQHSAAETSGDAG 6201
Query: 379 SQVDRLYVALKELGEERRV---------ALEQQY-----WLYQLSRQVSELEHWIAEKEV 424
+ D L L GE+ +L Q++ L + Q E + +
Sbjct: 6202 EKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRL 6261
Query: 425 VAGSPELGQDF---------EHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH 475
++G P D + L + F E +S++G A R+ + ++ D G
Sbjct: 6262 LSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYD-----GV 6316
Query: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535
+A +T W D + E L+ + ++E+ D +E+ ++++ + +
Sbjct: 6317 SATST---WLDDVEERLFVATALLPEETETCLFNQEI--LAKDIKEMSEEMDKNKNLFSQ 6371
Query: 536 LTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQ 569
PE + ++ TL L LL S V Q
Sbjct: 6372 AF--PENGDNRDVIEDTLGCLLGRLSLLDSVVNQ 6403
Score = 46.6 bits (109), Expect = 8e-05
Identities = 138/758 (18%), Positives = 276/758 (36%), Gaps = 151/758 (19%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQ---QLMQEKPELAASVRKK---LGEI 64
D HK + + L + E K +++E Q +LM + + K+ L I
Sbjct: 6557 DKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYI 6616
Query: 65 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL-------HMESQLQDVDPG-- 115
+ W+ L+ Q +RQL + V E + +L+ H++S L + P
Sbjct: 6617 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLY 6676
Query: 116 -------------------------GD--LATVNSQLKKLQSMESQVEEWYREVGE---- 144
G+ L+ N K+L +E+ ++ W R E
Sbjct: 6677 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 6736
Query: 145 ----------LQAQTAALPLEPASKELVGERQNA--------------------VGERLV 174
L+ T P E+V + NA G +L+
Sbjct: 6737 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6796
Query: 175 RL-----------LEPLQERRRLLLAS-----KELHQVA-------HDLDDELAWVQERL 211
RL L + + LL + ++LHQ+ H + + ++W+ +
Sbjct: 6797 RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWIS-LM 6855
Query: 212 PLAMQTERGN-----GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE 266
+Q + N G +A+ ++++K +G + +I ++ V + ++ + S + E
Sbjct: 6856 ENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQ---SVLQISSQDVE 6912
Query: 267 AVRRG-------LEQLQSAWAGLREAAERRQQVLDAAFQV-EQYYFDVAEVEAWLGEQEL 318
+ R L + +W L+ + Q+L+ + +Y +V ++ W QE
Sbjct: 6913 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 6972
Query: 319 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQI---- 374
+ + + D+ S LK LE ++ E+ + ++ + AL++ D I
Sbjct: 6973 RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 7032
Query: 375 --------SRRQSQVDRLYVALKELGEE---RRVALEQQYWLYQLSRQVSELEHWIAEKE 423
+ V +L + LK + ++ +VA ++ ++ + E + ++
Sbjct: 7033 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK------INSYLMEARYSLSRFR 7086
Query: 424 VVAGSPELGQ-DFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482
++ GS E Q +++ LQ+ + G + NQ+ L EC T+
Sbjct: 7087 LLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFG----SITNQL---LKECHPPVTETLT 7139
Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSD-ARELQGQIEEKRRRLPRLTTPPE 541
+N W LLE + + Q A +L + + D +++ ++++ R L
Sbjct: 7140 NTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAAT 7199
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQ----LQEGAAQLRTVYAGEHAEAIASREQEVL 597
+ A T +DL + V+ L E QL+ A AI S + +
Sbjct: 7200 NKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS 7259
Query: 598 QGWKELLSA-CEDARLHVSSTADALRFHSQVRDLLSWM 634
Q L A C+ + D F + L +W+
Sbjct: 7260 QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 7297
Score = 44.7 bits (104), Expect = 3e-04
Identities = 122/621 (19%), Positives = 244/621 (39%), Gaps = 75/621 (12%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQE-KPELAASVRKKLGEIRQCWAELESTTQAKAR 80
H+ F AE+ ++ L I +GQ+L+++ + + KL + W + Q +
Sbjct: 7426 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7485
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+ + Q + AE +K L S L P L +V L++ +++ +V+ ++
Sbjct: 7486 IIDSQIRQWQRYREMAEKLRKWLVEVSYL----PMSGLGSVPIPLQQARTLFDEVQ--FK 7539
Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER-----RRLLLASKELHQ 195
E L+ Q + + A K+L+ + L L +QE+ RL K+L
Sbjct: 7540 EKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF 7599
Query: 196 VAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAG 255
+ D + + + L ++T + Q++ H E+ A R +E+ G
Sbjct: 7600 LLKDWEKCEKGIADSLE-KLRTFKKKLSQSLPDH-------HEELHAEQMRCKELENAVG 7651
Query: 256 A---------------LASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQV 299
+ A + + + + +E LQ W L + + RRQQ+ + +
Sbjct: 7652 SWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEW 7711
Query: 300 EQYYFDVAEVEAWLGEQE----------LLMMSEDKGKDEQSTLQLLKKH-LQLEQGVEN 348
+ E+ WL + E + M E KD Q + + +++ +QL+Q
Sbjct: 7712 AVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQ---- 7767
Query: 349 YEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQL 408
E +A+ S + +A E+ + + R Q +D + +K+L +E VA++ QL
Sbjct: 7768 MGERLAKASHESKA-SEIEYKLGKVNDRWQHLLDLIAARVKKL-KETLVAVQ------QL 7819
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS--------ETGMAGRERL 460
+ +S L W+A E P + D + +Q K +E TG+A L
Sbjct: 7820 DKNMSSLRTWLAHIESELAKP-IVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL 7878
Query: 461 AAVNQMVDELIECGHTAAA-TMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKFFSD 518
V ++ + C A ++ + L+ W + + M R ++ R KF D
Sbjct: 7879 CEV--LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 7936
Query: 519 ARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLR 578
+ ++ R ++ A + AF+ + ++Q+ + + Q R
Sbjct: 7937 YSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINK---QYR 7993
Query: 579 TVYAGEHAEAIASREQEVLQG 599
+ ++ S +Q V +G
Sbjct: 7994 RLARENRTDSACSLKQMVHEG 8014
Score = 43.9 bits (102), Expect = 5e-04
Identities = 62/314 (19%), Positives = 123/314 (39%), Gaps = 26/314 (8%)
Query: 95 FAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPL 154
F + KL ME + Q VD A +++ + +VEE E+ ++
Sbjct: 3600 FNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSR 3659
Query: 155 EPASKELVGERQNAVGERLVRLLEP----------LQERRRLLLASKELHQVAHDLDDEL 204
+ R A+ L+++LE L+E L + + + H +
Sbjct: 3660 MGCQATQLTSRYQAL---LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNV 3716
Query: 205 AWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE 264
A +++ M ++ L+ + + ++K L + + G R + LE E
Sbjct: 3717 ATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEG---------E 3767
Query: 265 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGE-QELLMMS 322
AE +R+ + L + L+ + + + D + + W+ E QE+L +
Sbjct: 3768 AERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3827
Query: 323 EDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDS--EQISRRQSQ 380
E+ + L K+ L+Q V ++E S+ + + ALLE+ + ++I + QS
Sbjct: 3828 EEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSD 3887
Query: 381 VDRLYVALKELGEE 394
L K + EE
Sbjct: 3888 YQDLCSIGKAMMEE 3901
Score = 42.7 bits (99), Expect = 0.001
Identities = 108/587 (18%), Positives = 218/587 (37%), Gaps = 84/587 (14%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE-KPELAASVRKKLGEIRQCWA 69
D L R L+ +A ++ + + ++ I G+ ++Q PE +++++L ++ WA
Sbjct: 3319 DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWA 3378
Query: 70 ELEST-TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD-PGGDLATVNSQLKK 127
L S + K++ SK + + ME+ L + + +L + L K
Sbjct: 3379 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3438
Query: 128 LQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLEPLQERR 184
+ + +V + + ++ + A + + + + ER A+ E R E + +
Sbjct: 3439 AKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQE---RAKEAVTKSE 3495
Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERG--------NGLQAVQQHIKKNQGL 236
+L+ +E + + L QE+L E LQ +Q H + Q L
Sbjct: 3496 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL 3555
Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295
L VL + P+AE R LE L+ W A +E R Q +
Sbjct: 3556 ----------LNSVLHTREDVIPSGIPQAE--DRALESLRQDWQAYQHRLSETRTQFNNV 3603
Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 355
++ +V+ WL E E K +E V Y + + +
Sbjct: 3604 VNKLRLMEQKFQQVDEWLKTAE-----EKKWHEE----------------VTAYRDEVEE 3642
Query: 356 LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL 415
+ + + +L+ H +S + R L ++ E+ + E+ L + +S
Sbjct: 3643 VGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSY 3702
Query: 416 EHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH 475
W ++F++V+ +K +T M G+ +L + ++ ++ E GH
Sbjct: 3703 SDWYGSTH---------KNFKNVATKIDKV-----DTVMMGK-KLKTLEVLLKDM-EKGH 3746
Query: 476 TAAATMAEWKDG----LNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRR 531
+ + E + L E AE L +E+H +EL + ++
Sbjct: 3747 SLLKSAREKGERAVKYLEEGEAERLR------------KEIHDHMEQLKELTSTVRKEHM 3794
Query: 532 RLPR-LTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577
L + L E ++ + + ++ L + +L E AQL
Sbjct: 3795 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQL 3841
Score = 40.4 bits (93), Expect = 0.005
Identities = 67/303 (22%), Positives = 123/303 (40%), Gaps = 24/303 (7%)
Query: 33 KEWLEKIEREGQQLMQEKPELAAS-VRKKLGEIRQCWAELESTTQAKARQLFEASKADQ- 90
K+ L + G+QL Q+ AAS ++ + Q LE K + +A D
Sbjct: 7226 KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQAL-CKQQTSLQAGVLDYE 7284
Query: 91 -LVQSFAELDKKLLHMESQLQDVDPG--GDLATVNSQLKKLQSMESQVEEWYREVGELQA 147
+S L+ ++ E LQ DP DL+T+ ++++L+ + ++ L
Sbjct: 7285 TFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE 7344
Query: 148 QTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWV 207
LPL KE+ +R + + ER L + HQ L+ W+
Sbjct: 7345 LGYRLPLN--DKEI--KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF--LEKCETWM 7398
Query: 208 QERLPLAMQTERGNGLQAV--QQHIKKNQGLRREIQAHGPRLEEVL-----ERAGALASL 260
+ +QTE+ ++ QH+ + Q QA +++L + L
Sbjct: 7399 E----FLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG 7454
Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQELL 319
+ + + L L + W G+ A++R+ ++D+ + Q Y ++AE + WL E L
Sbjct: 7455 QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYL 7514
Query: 320 MMS 322
MS
Sbjct: 7515 PMS 7517
Score = 38.9 bits (89), Expect = 0.016
Identities = 100/569 (17%), Positives = 219/569 (38%), Gaps = 98/569 (17%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82
Q A+L Q E ++I + +++ + V K + +I + ++E + A+
Sbjct: 2282 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ-- 2339
Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142
++ + ++ ++ K+L +S + +NS +K S E + +
Sbjct: 2340 ---NETCEALKKVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELE------SL 2385
Query: 143 GELQAQTAALPLEPASKELVGERQNAVGERLVR-LLEPLQERRRLLLASKELHQVAHDLD 201
G +A T + A +L + Q ++ E L + E +QE + L +K + + D
Sbjct: 2386 G--RAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRT 2443
Query: 202 DELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLR 261
+ ++ +L + LQ + + Q + G L L + +
Sbjct: 2444 GDSKVLEAKL---------HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSK-----QIV 2489
Query: 262 SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM 321
S E + + E+ Q A L++ + +Q + D A ++ + ++ W+ E E
Sbjct: 2490 SSIQEQITKANEEFQ---AFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFN 2546
Query: 322 SEDKGKDEQSTLQLLKKHLQLEQGVENY---EESIAQLSRQCRALLEMGHPDSEQISRRQ 378
+E+ G+ +Q + + ++E + ES+ +LS++ + L E GH ++ R
Sbjct: 2547 TENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQE-GRLC 2605
Query: 379 SQVDRLYVALKELGEER----RVALEQQYWLYQLSRQ----VSELEHWIAEKEVVAGSPE 430
SQ+ + L + +E+ +VAL++ L + + V ++ +A E GS +
Sbjct: 2606 SQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKD 2665
Query: 431 -LGQDFEHVSVLQEKFSEFASETGMA---GRERLAAVNQ-------------------MV 467
L + + + E + MA G + L + N+ ++
Sbjct: 2666 TLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIM 2725
Query: 468 DELIECGHTAAATMAEWKD---------------------------GLNEAWAELLELMG 500
+ T + +++W D GL E + L L
Sbjct: 2726 SSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQS 2785
Query: 501 TRAQLLAASRELHKFFSDARELQGQIEEK 529
++ +R LH+ + +REL + E++
Sbjct: 2786 ILSEAEDHTRALHRLIAKSRELYEKTEDE 2814
Score = 37.4 bits (85), Expect = 0.046
Identities = 122/634 (19%), Positives = 231/634 (36%), Gaps = 99/634 (15%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQE-----KPELAASVRKKLGEIRQCWAELESTTQA 77
+A M E+A ++ L ++ +G L+ + + +L +V L + ++ + ST Q
Sbjct: 3896 KAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQR 3955
Query: 78 KARQLFE-----ASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSME 132
+ L S+ D L Q A L +E Q P A Q+K ++++
Sbjct: 3956 MYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ---PPLSRAEAIKQVKHFRALQ 4012
Query: 133 SQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKE 192
Q Y ++ + ++ +K+ + + + + ++LV+ Q + E
Sbjct: 4013 EQART-YLDLLCSMCDLSNASVKTTAKD-IQQTEQTIEQKLVQAQNLTQGWEEIKHLKSE 4070
Query: 193 LHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLE 252
L D D +L ++ R N + V+ +KK Q + + ++E
Sbjct: 4071 LWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNT-------IIE 4123
Query: 253 RAGALASLR-SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEA 311
+ L SPE + + L W L + + Q + Y D V
Sbjct: 4124 KVNKLTKKEESPE----HKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVE 4179
Query: 312 WLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDS 371
E+ D +ST L+ +L ++ + +I L Q
Sbjct: 4180 VFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQ------------ 4227
Query: 372 EQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPEL 431
+Q ++ L + KEL +E+ LEQ+++ +LE I K V+ +
Sbjct: 4228 -----KQKMIEHLNLDDKELVKEQTSHLEQRWF---------QLEDLIKRKIQVSVT--- 4270
Query: 432 GQDFEHVSVLQEKFS---EFASETGMAGRERL-------AAVNQMVDELIECGHTAAATM 481
+ E ++V+Q +F E+A E E L A N ++D L C A M
Sbjct: 4271 --NLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4328
Query: 482 ---AEWKD--------GLNEAWAE-------------LLELMGTRAQLL-AASRELHKFF 516
+ KD GLNE L +L+G R + L A E +F
Sbjct: 4329 LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFL 4388
Query: 517 SDARELQGQIEEKRRRL---PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEG 573
+ QI++ R++ + P+ S +T ++ + L+ ++V L
Sbjct: 4389 MAVFQATSQIQQHERKIMFREHICLLPD---DVSKQVKTCKSAQASLKTYQNEVTGLWAQ 4445
Query: 574 AAQLRTVYAGEHAEAIASREQEVLQGWKELLSAC 607
+L + + + QE+ + +L C
Sbjct: 4446 GRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC 4479
Score = 37.0 bits (84), Expect = 0.060
Identities = 93/533 (17%), Positives = 203/533 (38%), Gaps = 46/533 (8%)
Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVG--ERQNAVGERLV 174
+++ V++ L+K+Q S+ E ++ + ++ L ++ G + A E
Sbjct: 3103 NISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWK 3162
Query: 175 RLLEPLQERRRLL----LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHI 230
L ++ L + K+ A + D L+ ++ + + + R L A ++
Sbjct: 3163 NFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHES--SNRLYDLPAKRREQ 3220
Query: 231 KKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQ 290
+K Q + EI + P+L + E+A L ++ +++ R + QL S + L + +
Sbjct: 3221 QKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA-ASKSFRHRVSQLSSQYLALSNLTKEKV 3279
Query: 291 QVLD-AAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349
LD + Q+ + E++ W+ + ++ S ++S L L+ V+
Sbjct: 3280 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3339
Query: 350 EE-SIAQLSRQCRALLEMGHPDSEQISRRQSQ-VDRLYVALKELGEERRVALE---QQYW 404
+E + + + ++L+ P+ ++Q Q V ++ +L G + LE ++
Sbjct: 3340 KEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWT 3399
Query: 405 LYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVN 464
YQ V + W+ E +++ + + +E +T M G+ +L
Sbjct: 3400 SYQ--DGVRQFSGWMDSMEA------------NLNESERQHAELRDKTTMLGKAKL---- 3441
Query: 465 QMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQG 524
++E + + T+ G+ E + LEL + + A + + + +L
Sbjct: 3442 --LNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVR 3499
Query: 525 QIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ----EGAAQLRTV 580
+E +R L L H + + +++LQ EG A L +V
Sbjct: 3500 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3559
Query: 581 YAGEH---AEAIASREQEVL----QGWKELLSACEDARLHVSSTADALRFHSQ 626
I E L Q W+ + R ++ + LR Q
Sbjct: 3560 LHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3612
Score = 36.2 bits (82), Expect = 0.10
Identities = 85/420 (20%), Positives = 165/420 (39%), Gaps = 42/420 (10%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPEL-AASVRKKLGEIRQCWAELESTTQAKARQ 81
+AF E++ N +E+I +G+QL+++ L AA + ++L E+R+ E+ + ++
Sbjct: 8079 KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8138
Query: 82 LFEASKADQLVQ-SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
L D S EL+ + S L D D L +Q R
Sbjct: 8139 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8198
Query: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199
+ A ++PLE +L + ++A+ L E Q+ + L
Sbjct: 8199 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMI 8258
Query: 200 LDDELAWVQ-----------ERLPLAMQTER-GNGLQAVQQHIKKNQGLRREIQAHGPRL 247
+ A+V+ + L Q + G L + I++ + + R GP L
Sbjct: 8259 PESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL 8318
Query: 248 EEVLERAGALASLRSPEAEAVRR----------------GLEQLQSAWAGLREAAERRQ- 290
+ + L S ++V+R L ++ AG+ + E Q
Sbjct: 8319 DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQA 8378
Query: 291 QVLDAAFQV-------EQYYFDVAEVEAWLG--EQELLMMSEDKGKDEQSTLQL-LKKHL 340
Q L ++ +Q+ D+ + AWLG E+EL + + + T++L +KK
Sbjct: 8379 QALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK 8438
Query: 341 QLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 400
+L++ V++ + I ++ + +S + R SQ++ + + L EE R L+
Sbjct: 8439 ELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQ 8498
Score = 35.8 bits (81), Expect = 0.13
Identities = 113/552 (20%), Positives = 214/552 (38%), Gaps = 90/552 (16%)
Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 69
E +++HK + F+ EL +E L+K+ + G QL+ E+ A + ++
Sbjct: 2559 EKKNEVHKV----EMFLGELLAARESLDKLSQRG-QLLSEEGHGAGQEGRLCSQLLTSHQ 2613
Query: 70 ELESTTQAKARQ----LFEASKADQLVQSF----AELDKKLLHMESQLQDVDPGGDLATV 121
L T+ K R L E ++ +QS + +L ES L G T+
Sbjct: 2614 NLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTL------GSKDTL 2667
Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 181
+L ++Q + E GE++ A E A + E Q + +L L E
Sbjct: 2668 EKRLSQIQDILLMKGE-----GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWA 2722
Query: 182 E-RRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
+ + A L V +D ER N L+ + + +Q + +
Sbjct: 2723 DIMSSSVHAQSTLESVISQWND-------------YVERKNQLEQWMESV--DQKIEHPL 2767
Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
Q P L+E L S+ S EAE R L +L + ++ E ++ D +F+
Sbjct: 2768 QPQ-PGLKEKFVLLDHLQSILS-EAEDHTRALHRL------IAKSRELYEKTEDESFK-- 2817
Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
D A+ E +++ ++++K + + +++K HL V + + + +
Sbjct: 2818 ----DTAQEELKTQFNDIMTVAKEKMRKVE---EIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
+M DS ++ S++ L + +E+G R +E + + S E
Sbjct: 2871 HRWSDMS-GDSSATQKKLSKIKEL-IDSREIGASRLSRVESLAPEVKQNTTASGCELMHT 2928
Query: 421 EKEVVAGSPELGQD--FEHVSVLQEKFSEFA-SETGMAGR--------ERLAAV------ 463
E + + + +D F+ S L+ S+ A SE +G+ E+ +A+
Sbjct: 2929 EMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQ 2988
Query: 464 -------NQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 516
+E++EC H E D L +A +L +L SR+L +
Sbjct: 2989 QLTLLEGKNTDEEIVECWHKG----QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY- 3043
Query: 517 SDARELQGQIEE 528
+ ++ G I+E
Sbjct: 3044 --SGKVSGLIKE 3053
Score = 35.8 bits (81), Expect = 0.13
Identities = 86/418 (20%), Positives = 163/418 (38%), Gaps = 53/418 (12%)
Query: 237 RREIQAHGPRLEEVLE------RAGALASLRSPEAEAVR-RGLEQLQSAWAGLREAAERR 289
R E++ G R +E+L+ R G A+ + +A+ + LEQ++ ++ E
Sbjct: 3637 RDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESE 3696
Query: 290 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349
+ + + + V + + + +MM + E + K H L+ E
Sbjct: 3697 SSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKG 3756
Query: 350 EESIAQLSR-QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQL 408
E ++ L + L + H EQ+ S V + ++ L E+ + L +++
Sbjct: 3757 ERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTL-----EKGLHLAKEF----- 3806
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS-----ETGMAGRERLAAV 463
S + L WIAE + + PE E L EK ++ + +T ++ + +V
Sbjct: 3807 SDKCKALTQWIAEYQEILHVPE-----EPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSV 3861
Query: 464 NQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE-LHKFFSDAREL 522
+ + L+E T+ + D L + +L + + +A + L+ L
Sbjct: 3862 REKGEALLEL--VQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTL 3919
Query: 523 QGQIEEKRRRLPRLT-------TPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575
GQ + + + T S+ QR ++ EH+LQ VS+ LQ+ A
Sbjct: 3920 IGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA 3979
Query: 576 QLRTVYAG---------EHAEAIASRE-----QEVLQGWKELL-SACEDARLHVSSTA 618
L V AEAI + QE + + +LL S C+ + V +TA
Sbjct: 3980 WLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4037
Score = 34.7 bits (78), Expect = 0.30
Identities = 111/623 (17%), Positives = 239/623 (38%), Gaps = 49/623 (7%)
Query: 38 KIEREGQQLMQEKPELAASVRKKLGEIRQCWAELE----STTQAKARQLFEASKADQLVQ 93
+++R G +L E+P + ++L +++ + EL S + L S+ ++ +Q
Sbjct: 6471 ELKRRGDKLQVEQPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6525
Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 153
A+L +E+ + + GD + S +++Q + + +E+++ + T L
Sbjct: 6526 DLADL------LETGQEKM--AGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLF 6577
Query: 154 LEPASKELVGERQ------NAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWV 207
+ S + E Q L R + E +L L + +L +L V
Sbjct: 6578 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV 6637
Query: 208 QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEA 267
+ +P E + I Q L+ + + P+L +VL+ L L S
Sbjct: 6638 ESSIPSVGLVEENE--DRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL--LISISCSD 6693
Query: 268 VRRGLEQLQSAWAGLREAAERRQQVLDAAFQV-EQYYFDVAEVEAWL-GEQELLMMSEDK 325
+ L QL W + L+ + +Y + A++ WL ++ L +
Sbjct: 6694 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ 6753
Query: 326 GKDEQSTLQLLKKHL----QLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQV 381
L++++ HL + + V+ + + LL + D+ + S++
Sbjct: 6754 SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRI 6813
Query: 382 DRLYVALKELGEERRVALEQQYWLYQLSRQ-VSELEHWIAEKEVVAGSPE------LGQD 434
D + L + L Q SR +SE+ WI+ E V E +G
Sbjct: 6814 DSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG-- 6871
Query: 435 FEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAATMAEWKDGLNE 490
++ + +K+ F + + + VNQ V ++ +E + AE +N+
Sbjct: 6872 YKAIHEYLQKYKGFKIDINCK-QLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNK 6930
Query: 491 AWAELLELMGTRAQLLAASRE-LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549
+W L L+ + QLL E ++ ++ + L+ E + +RL + + + S +
Sbjct: 6931 SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNA 6989
Query: 550 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609
+ + E ++ +V ++++ L + + + S +E+ Q W L
Sbjct: 6990 LKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQ 7049
Query: 610 ARLHVSSTADALRFHSQVRDLLS 632
++ + S D H D ++
Sbjct: 7050 LKILLKSVLDQWSSHKVAFDKIN 7072
Score = 33.1 bits (74), Expect = 0.86
Identities = 47/236 (19%), Positives = 102/236 (43%), Gaps = 20/236 (8%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81
++ +M L + ++ ++R +L +E+ L V E Q ++ +A+
Sbjct: 8322 YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET-QTAGVIDRWELLQAQA 8380
Query: 82 LFEASKADQLVQSFAELDKKLLHMES----------QLQDVDPGGDLATVNSQLKKLQSM 131
L + + Q +Q + + + L + + QLQ ++ D+ T+ Q+KKL+ +
Sbjct: 8381 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKEL 8440
Query: 132 ESQVEEWYREVGELQAQTAALPLEPA-SKEL--VGERQNAVGERLVRLLEPLQERRRL-- 186
+ V+ +R+ L + A SKE + +R + + R R+ L+E R L
Sbjct: 8441 QKAVD--HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQ 8498
Query: 187 --LLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
L+ + H+++H L L + R + + + +Q H K+ ++ E+
Sbjct: 8499 DALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 8554
Score = 32.7 bits (73), Expect = 1.1
Identities = 92/467 (19%), Positives = 179/467 (38%), Gaps = 79/467 (16%)
Query: 28 ELAQNKEWLEKIEREGQQLM---QEKPELAASVRKKLGEIRQCWAELESTTQAKA----- 79
+L + KE + E QQL+ +E + S LG+I + LE Q+ A
Sbjct: 802 QLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQK 861
Query: 80 ------------RQLFEASKADQLVQSFAELDKKLLH-----MESQLQDVDPG------- 115
+ L K Q VQ F L L H ++ Q+ D+
Sbjct: 862 HQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKK 921
Query: 116 -GD----LATVNSQLKKLQSMESQVEEWYREVGE-LQAQTAALPLEPASKELVGERQNAV 169
GD + T + +KK + +++E+ R E L+ + L E + V
Sbjct: 922 TGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV 981
Query: 170 GERLVRLLE------PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 223
++ + P QE++ L A ++LH+ DL E + L L + E+ L
Sbjct: 982 LNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPY--HLLHLKIDVEKNRFL 1039
Query: 224 QAVQQ---------HIKKNQGLRREIQAH-------GPR--LEEVLERAGALASLRSPEA 265
+V++ + +G + I+ H GP E+ L+ L ++ P
Sbjct: 1040 ASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELC-VKLPVR 1098
Query: 266 EAVRRGLEQLQSAWAGLREAAERR-QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMS-E 323
+ VR LR A + +++++ + + Y +E +W+ E + +
Sbjct: 1099 DPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIK 1158
Query: 324 DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383
+ D + ++ + ++ GV E+++ L + + L E+ + Q ++ ++ +
Sbjct: 1159 GEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQ--KQGDELAK 1216
Query: 384 LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430
L + K L V L L ++ + +S + KE+V S E
Sbjct: 1217 LSSSFKAL-----VTL-----LSEVEKMLSNFGDCVQYKEIVKNSLE 1253
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 77.8 bits (190), Expect = 3e-14
Identities = 119/622 (19%), Positives = 260/622 (41%), Gaps = 68/622 (10%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
EL + + L+ +ER ++ ++ + ++RK W E+ + R LF+
Sbjct: 1313 ELRKLESTLDGLERSRER---QERRIQVTLRK--------WERFETNKETVVRYLFQTGS 1361
Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147
+ + SF+ L+ + S+L+ K+ +S+ Q E +E E+
Sbjct: 1362 SHERFLSFSSLES----LSSELEQTKEFS---------KRTESIAVQAENLVKEASEI-- 1406
Query: 148 QTAALPLEPASKELVGERQNAVGERLVRLLEPLQER-RRLLLASKELHQVAHDLDDELAW 206
PL P +K+L+ ++ ++ E++ +L + L+E + + + + + + W
Sbjct: 1407 -----PLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVW 1461
Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS-LRSPEA 265
+ E+ E + A+ I + + +EI++ + + E A + A + + E+
Sbjct: 1462 ITEKEKELNALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGES 1519
Query: 266 EAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQVEQYYFDVAEVEAWLGE-QELLMMSE 323
++ L Q++ LRE A+ + +L Q +++ ++ +++ + E ++ L +
Sbjct: 1520 ARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPI 1579
Query: 324 DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383
T ++L++H+ L Q +E+ +I S R ++ E + +Q D
Sbjct: 1580 KICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDI 1639
Query: 384 LYVALKELGEERRVALEQ--QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSV- 440
L A +ER+ ALE +W +L +++S W+ E A SPE+ + V V
Sbjct: 1640 LRRA-----KERQTALENLLAHW-QRLEKELSSFLTWLERGEAKASSPEMDISADRVKVE 1693
Query: 441 -----LQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAE 494
+Q +E S+ + + Q+ + L M + + L+E W +
Sbjct: 1694 GELQLIQALQNEVVSQASFYSK-----LLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1748
Query: 495 LLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR 554
L +++ R L + H+ F + L + L L T E S M +
Sbjct: 1749 LPQIINKRINFLQSVVAEHQQFDEL--LLSFSVWIKLFLSELQTTSE----ISIMDHQVA 1802
Query: 555 AFEH-----DLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609
H +++ +++ LQ A+L ++ E + + ++ Q ++E E
Sbjct: 1803 LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVER 1862
Query: 610 ARLHVSSTADALRFHSQVRDLL 631
+L +S A+ L+ H+ + +L
Sbjct: 1863 RQLALSHLAEFLQSHASLSGIL 1884
Score = 63.9 bits (154), Expect = 5e-10
Identities = 108/577 (18%), Positives = 221/577 (38%), Gaps = 43/577 (7%)
Query: 59 KKLGEIRQCWAELESTTQAKARQLFEA-SKADQLVQSFAELDKKLLHMESQLQD-VDPGG 116
+ L +RQ W + Q +K + Q F ++D+ L E ++
Sbjct: 3570 RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQS 3629
Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176
+ AT QL +++ +V + EV E+ A+ + E +G + + R L
Sbjct: 3630 NRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQAL 3689
Query: 177 L--------------EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG 222
L + L+E L + + + H +A +++ M ++
Sbjct: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749
Query: 223 LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL 282
L+ + + ++K L + + G R + LE EAE +R+ + L
Sbjct: 3750 LEVLLKDMEKGHSLLKSAREKGERAVKYLEEG---------EAERLRKEIHDHMEQLKEL 3800
Query: 283 REAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGE-QELLMMSEDKGKDEQSTLQLLKKHL 340
+ L+ + + + D + + W+ E QE+L + E+ + L K+
Sbjct: 3801 TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYK 3860
Query: 341 QLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 400
L+Q V ++E S+ + + ALLE+ + + Q Q D Y L +G+E +LE
Sbjct: 3861 SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSD--YQDLCSIGKEHVFSLE 3918
Query: 401 QQYWLYQ-LSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG-RE 458
+ ++ + ++ E+E W+ + +P+L + ++ Q+ A +AG +
Sbjct: 3919 AKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
Query: 459 RLAAVNQMVDELI-ECGHTAAATMAE----WKDGLNEAWAELLELMGTRAQLLAASRELH 513
RL + D LI +C A + + G ++++ + Q L + H
Sbjct: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
Query: 514 KFFSDA-RELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQL---LVSQVRQ 569
D ++ Q + + L PP R A + RA + + L+ +
Sbjct: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCD 4098
Query: 570 LQEGAAQLRTVYAGEHAEAIASR---EQEVLQGWKEL 603
L + + + + I + Q + QGW+E+
Sbjct: 4099 LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
Score = 53.1 bits (126), Expect = 8e-07
Identities = 123/675 (18%), Positives = 264/675 (39%), Gaps = 77/675 (11%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE-KPELAASVRKKLGEIRQCWA 69
D L R L+ +A ++ + + ++ I G+ ++Q PE +++++L ++ WA
Sbjct: 3312 DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWA 3371
Query: 70 ELEST-TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD-PGGDLATVNSQLKK 127
L S + K++ SK + + ME+ L + + +L + L K
Sbjct: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
Query: 128 LQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLEPLQERR 184
+ + +V + + ++ + A + + + + ER A+ E R E + +
Sbjct: 3432 AKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQE---RAKEAVTKSE 3488
Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERG--------NGLQAVQQHIKKNQGL 236
+L+ +E + + L QE+L E LQ +Q H + Q L
Sbjct: 3489 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL 3548
Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295
L VL + P+AE R LE L+ W A +E R Q +
Sbjct: 3549 ----------LNSVLHTREDVIPSGIPQAE--DRALESLRQDWQAYQHRLSETRTQFNNV 3596
Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354
++ +V+ WL E + + + ++T ++ L + + + V Y + +
Sbjct: 3597 VNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVE 3656
Query: 355 QLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE 414
++ + + +L+ H +S + R L ++ E+ + E+ L + +S
Sbjct: 3657 EVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSS 3716
Query: 415 LEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECG 474
W ++F++V+ +K +T M G+ +L + ++ ++ E G
Sbjct: 3717 YSDWYGSTH---------KNFKNVATKIDKV-----DTVMMGK-KLKTLEVLLKDM-EKG 3760
Query: 475 HTAAATMAEWKDG----LNEAWAELL-----ELMGTRAQLLAASRELHKFFSDARELQGQ 525
H+ + E + L E AE L + M +L + R+ H L +
Sbjct: 3761 HSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKE 3820
Query: 526 IEEKRRRLPR--------LTTPPEPRPSASSMQRTLRAFEHDLQLLVS------QVRQLQ 571
+K + L + L P EP+ + L ++ Q ++S VR+
Sbjct: 3821 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880
Query: 572 EGAAQL-RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDL 630
E +L + V + + + S Q++ KE + + E + D ++S+++++
Sbjct: 3881 EALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLE------AKVKDHEDYNSELQEV 3934
Query: 631 LSWMDGIASQIGAAD 645
W+ ++ ++ A D
Sbjct: 3935 EKWLLQMSGRLVAPD 3949
Score = 53.1 bits (126), Expect = 8e-07
Identities = 110/554 (19%), Positives = 219/554 (39%), Gaps = 76/554 (13%)
Query: 48 QEKPELAASVRKKLGEIRQCWAEL-ESTTQAKARQLFEASKADQLVQSFAELDKKLLHME 106
QE ++ + ++L +++ +++ E T A+ + S A L S L + +H+E
Sbjct: 4781 QEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLE 4840
Query: 107 SQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQ 166
+DP + Q++ W GEL+ T+A +GE
Sbjct: 4841 DLAPHLDP-----------LAYEKARHQIQSWQ---GELKLLTSA----------IGETV 4876
Query: 167 NAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAV 226
R+V+ ++ E R L D L V+ L + + LQ +
Sbjct: 4877 TECESRMVQSIDFQTEMSRSL--------------DWLRRVKAELSGPVYLDLN--LQDI 4920
Query: 227 QQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE--AEAVRRGLEQLQSAWAGLRE 284
Q+ I+K Q + E+Q+ R+ L ++ E + + L +L ++E
Sbjct: 4921 QEEIRKIQIHQEEVQS-SLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
Query: 285 AAERRQQVLDAAF-QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLE 343
A RQ L + Q ++YY WL + + L+ G D +S + LK H++
Sbjct: 4980 ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFF 5039
Query: 344 QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEER--RVALEQ 401
+ + ++ +L L + P ++ ++ VA EL +R R + Q
Sbjct: 5040 STEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQK-------VASLELRSQRMSRDSGAQ 5092
Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL--------QEKFSEFASETG 453
L + + Q + + A +EV+ + + S+L +EK SE +
Sbjct: 5093 VDLLQRCTAQWHDYQK--AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
Query: 454 MAG--RERLAAVNQMVDELIECGHTAA-ATMAEWKDGLNEAWAELLELMGTRAQLLA-AS 509
+ E++ A+ + +L + G+ A+ AT++ + + W L + + ++L A
Sbjct: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
Query: 510 RELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDL---QLLVSQ 566
E F + ++ I++ + +LP + + ++ F +L Q +
Sbjct: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
Query: 567 VRQ-----LQEGAA 575
+RQ LQ+GAA
Sbjct: 5271 LRQQTLSMLQDGAA 5284
Score = 50.4 bits (119), Expect = 5e-06
Identities = 113/572 (19%), Positives = 238/572 (41%), Gaps = 52/572 (9%)
Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95
L +++ Q+ +++ +L + KK+G++ + + T + +L + ++A ++ +
Sbjct: 5476 LMELDAAVQKFLEQNGQLGKPLAKKIGKLTELH---QQTIRQAENRLSKLNQAASHLEEY 5532
Query: 96 AELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-GELQAQTAALPL 154
E+ + +L + + + G SQL++ + + E +E+ EL+A T L
Sbjct: 5533 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKL-- 5590
Query: 155 EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL---DDELAWVQERL 211
+ + E+ + L R E L++ ++ L + L A D+ + EL +Q L
Sbjct: 5591 QYLTSVYCTEKMSQQVAELGRETEELRQMIKIRL--QNLQDAAKDMKKFEAELKKLQAAL 5648
Query: 212 PLAMQTERGN--GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR 269
A T G ++++ + Q L E+++ P+++ V AL R PE
Sbjct: 5649 EQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSAL---RIPEDVVAS 5705
Query: 270 RGL----EQLQSAWAGLREAAERRQQVLDAAF-QVEQYYFDVAEVEAWL--GEQELLMMS 322
L +LQ + L+ A ++ ++ AA Q EQY ++ ++ + +E+
Sbjct: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI---- 5761
Query: 323 EDKGKDEQSTLQL---LKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 379
EDK + +L + +H +L Q ++ Y+E IA L+ +C+ L + ++ +
Sbjct: 5762 EDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLT--VT 5819
Query: 380 QVDRLYVALKELGEE--------RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPEL 431
+V+ L ++L E V + + L V+E ++ P
Sbjct: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC 5879
Query: 432 GQDF----EHVSVLQE--KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485
SV Q+ + ++E ++ E E G +AT A+
Sbjct: 5880 RSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT-AKLG 5938
Query: 486 DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLP-RLTTPPEPRP 544
D L +W L ++ + + L + E + + D+ + I K + +L+ PEP
Sbjct: 5939 D-LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ---SISTKMEAIELKLSESPEPGR 5994
Query: 545 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576
S S +A ++ +L ++ +LQ A+
Sbjct: 5995 SPESQMAEHQALMDEILMLQDEINELQSSLAE 6026
Score = 50.1 bits (118), Expect = 7e-06
Identities = 121/574 (21%), Positives = 226/574 (39%), Gaps = 79/574 (13%)
Query: 50 KPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ-SFAELDKKLLHMESQ 108
+P L S KLG++++ W L++ K R L+EA + Q Q S + K+ +E +
Sbjct: 5926 EPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELK 5985
Query: 109 L-QDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQN 167
L + +PG + SQ+ + Q++ ++ E+ ELQ+ A L S E Q
Sbjct: 5986 LSESPEPG---RSPESQMAEHQALMDEILMLQDEINELQSSLAE-ELVSESCEADPAEQL 6041
Query: 168 AVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG----- 222
A+ L L E + R + AS + + L+D+L ++R A+Q R
Sbjct: 6042 ALQSTLTVLAERMSTIR--MKASGKRQLLEEKLNDQLE--EQRQEQALQRYRCEADELDS 6097
Query: 223 --------LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL-------------- 260
L K+ + ++ L E+ ++ AL+ L
Sbjct: 6098 WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAH 6157
Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQVEQYYFDVAEVEAWLGEQELL 319
EAE + L +L+ + L+ A +Q + A + E+ D+ ++ G QE L
Sbjct: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWL 6216
Query: 320 MMSEDK-GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQ 378
+ + QS+LQ K +LEQ + + + ++ + +L + H +E
Sbjct: 6217 AQARTTWTQQRQSSLQQQK---ELEQELAEQKSLLRSVASRGEEIL-IQHSAAETSGDAG 6272
Query: 379 SQVDRLYVALKELGEERRV---------ALEQQY-----WLYQLSRQVSELEHWIAEKEV 424
+ D L L GE+ +L Q++ L + Q E + +
Sbjct: 6273 EKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRL 6332
Query: 425 VAGSPELGQDF---------EHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH 475
++G P D + L + F E +S++G A R+ + ++ D G
Sbjct: 6333 LSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYD-----GV 6387
Query: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535
+A +T W D + E L+ + ++E+ D +E+ ++++ + +
Sbjct: 6388 SATST---WLDDVEERLFVATALLPEETETCLFNQEI--LAKDIKEMSEEMDKNKNLFSQ 6442
Query: 536 LTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQ 569
PE + ++ TL L LL S V Q
Sbjct: 6443 AF--PENGDNRDVIEDTLGCLLGRLSLLDSVVNQ 6474
Score = 46.6 bits (109), Expect = 8e-05
Identities = 138/758 (18%), Positives = 276/758 (36%), Gaps = 151/758 (19%)
Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQ---QLMQEKPELAASVRKK---LGEI 64
D HK + + L + E K +++E Q +LM + + K+ L I
Sbjct: 6628 DKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYI 6687
Query: 65 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL-------HMESQLQDVDPG-- 115
+ W+ L+ Q +RQL + V E + +L+ H++S L + P
Sbjct: 6688 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLY 6747
Query: 116 -------------------------GD--LATVNSQLKKLQSMESQVEEWYREVGE---- 144
G+ L+ N K+L +E+ ++ W R E
Sbjct: 6748 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 6807
Query: 145 ----------LQAQTAALPLEPASKELVGERQNA--------------------VGERLV 174
L+ T P E+V + NA G +L+
Sbjct: 6808 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
Query: 175 RL-----------LEPLQERRRLLLAS-----KELHQVA-------HDLDDELAWVQERL 211
RL L + + LL + ++LHQ+ H + + ++W+ +
Sbjct: 6868 RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWIS-LM 6926
Query: 212 PLAMQTERGN-----GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE 266
+Q + N G +A+ ++++K +G + +I ++ V + ++ + S + E
Sbjct: 6927 ENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQ---SVLQISSQDVE 6983
Query: 267 AVRRG-------LEQLQSAWAGLREAAERRQQVLDAAFQV-EQYYFDVAEVEAWLGEQEL 318
+ R L + +W L+ + Q+L+ + +Y +V ++ W QE
Sbjct: 6984 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 7043
Query: 319 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQI---- 374
+ + + D+ S LK LE ++ E+ + ++ + AL++ D I
Sbjct: 7044 RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 7103
Query: 375 --------SRRQSQVDRLYVALKELGEE---RRVALEQQYWLYQLSRQVSELEHWIAEKE 423
+ V +L + LK + ++ +VA ++ ++ + E + ++
Sbjct: 7104 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK------INSYLMEARYSLSRFR 7157
Query: 424 VVAGSPELGQ-DFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482
++ GS E Q +++ LQ+ + G + NQ+ L EC T+
Sbjct: 7158 LLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFG----SITNQL---LKECHPPVTETLT 7210
Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSD-ARELQGQIEEKRRRLPRLTTPPE 541
+N W LLE + + Q A +L + + D +++ ++++ R L
Sbjct: 7211 NTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAAT 7270
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQ----LQEGAAQLRTVYAGEHAEAIASREQEVL 597
+ A T +DL + V+ L E QL+ A AI S + +
Sbjct: 7271 NKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS 7330
Query: 598 QGWKELLSA-CEDARLHVSSTADALRFHSQVRDLLSWM 634
Q L A C+ + D F + L +W+
Sbjct: 7331 QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 7368
Score = 44.7 bits (104), Expect = 3e-04
Identities = 122/621 (19%), Positives = 244/621 (39%), Gaps = 75/621 (12%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQE-KPELAASVRKKLGEIRQCWAELESTTQAKAR 80
H+ F AE+ ++ L I +GQ+L+++ + + KL + W + Q +
Sbjct: 7497 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7556
Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
+ + Q + AE +K L S L P L +V L++ +++ +V+ ++
Sbjct: 7557 IIDSQIRQWQRYREMAEKLRKWLVEVSYL----PMSGLGSVPIPLQQARTLFDEVQ--FK 7610
Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER-----RRLLLASKELHQ 195
E L+ Q + + A K+L+ + L L +QE+ RL K+L
Sbjct: 7611 EKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF 7670
Query: 196 VAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAG 255
+ D + + + L ++T + Q++ H E+ A R +E+ G
Sbjct: 7671 LLKDWEKCEKGIADSLE-KLRTFKKKLSQSLPDH-------HEELHAEQMRCKELENAVG 7722
Query: 256 A---------------LASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQV 299
+ A + + + + +E LQ W L + + RRQQ+ + +
Sbjct: 7723 SWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEW 7782
Query: 300 EQYYFDVAEVEAWLGEQE----------LLMMSEDKGKDEQSTLQLLKKH-LQLEQGVEN 348
+ E+ WL + E + M E KD Q + + +++ +QL+Q
Sbjct: 7783 AVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQ---- 7838
Query: 349 YEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQL 408
E +A+ S + +A E+ + + R Q +D + +K+L +E VA++ QL
Sbjct: 7839 MGERLAKASHESKA-SEIEYKLGKVNDRWQHLLDLIAARVKKL-KETLVAVQ------QL 7890
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS--------ETGMAGRERL 460
+ +S L W+A E P + D + +Q K +E TG+A L
Sbjct: 7891 DKNMSSLRTWLAHIESELAKP-IVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL 7949
Query: 461 AAVNQMVDELIECGHTAAA-TMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKFFSD 518
V ++ + C A ++ + L+ W + + M R ++ R KF D
Sbjct: 7950 CEV--LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 8007
Query: 519 ARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLR 578
+ ++ R ++ A + AF+ + ++Q+ + + Q R
Sbjct: 8008 YSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINK---QYR 8064
Query: 579 TVYAGEHAEAIASREQEVLQG 599
+ ++ S +Q V +G
Sbjct: 8065 RLARENRTDSACSLKQMVHEG 8085
Score = 41.2 bits (95), Expect = 0.003
Identities = 85/402 (21%), Positives = 159/402 (39%), Gaps = 29/402 (7%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPEL-AASVRKKLGEIRQCWAELESTTQAKARQ 81
+AF E++ N +E+I +G+QL+++ L AA + ++L E+R+ E+ + ++
Sbjct: 8150 KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
Query: 82 LFEASKADQLVQ-SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
L D S EL+ + S L D D L +Q R
Sbjct: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
Query: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLAS--------- 190
+ A ++PLE +L + ++A+ L E Q+ + L
Sbjct: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS 8329
Query: 191 ---KELHQVAHDLDDELAWVQERLPLAM-QTERGNGLQAVQQHIKKNQGLRREIQAHGPR 246
++ Q+ LDD +Q+ + +T G L + K G R
Sbjct: 8330 ALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKR 8389
Query: 247 LEEVL----ERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV-EQ 301
LE L E +L S E + + W L+ A ++ + Q +Q
Sbjct: 8390 LEHKLKEEEESLPGFVNLHSTETQTAG-----VIDRWELLQAQALSKELRMKQNLQKWQQ 8444
Query: 302 YYFDVAEVEAWLG--EQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIAQLSR 358
+ D+ + AWLG E+EL + + + T++L +KK +L++ V++ + I ++
Sbjct: 8445 FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINL 8504
Query: 359 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 400
+ +S + R SQ++ + + L EE R L+
Sbjct: 8505 CSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQ 8546
Score = 40.4 bits (93), Expect = 0.005
Identities = 123/635 (19%), Positives = 232/635 (36%), Gaps = 99/635 (15%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQE-----KPELAASVRKKLGEIRQCWAELESTTQ 76
H+A M E+A ++ L ++ +G L+ + + +L +V L + ++ + ST Q
Sbjct: 3966 HKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQ 4025
Query: 77 AKARQLFE-----ASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 131
+ L S+ D L Q A L +E Q P A Q+K +++
Sbjct: 4026 RMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ---PPLSRAEAIKQVKHFRAL 4082
Query: 132 ESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASK 191
+ Q Y ++ + ++ +K+ + + + + ++LV+ Q +
Sbjct: 4083 QEQART-YLDLLCSMCDLSNASVKTTAKD-IQQTEQTIEQKLVQAQNLTQGWEEIKHLKS 4140
Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVL 251
EL D D +L ++ R N + V+ +KK Q + + ++
Sbjct: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNT-------II 4193
Query: 252 ERAGALASLR-SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVE 310
E+ L SPE + + L W L + + Q + Y D V
Sbjct: 4194 EKVNKLTKKEESPE----HKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4249
Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
E+ D +ST L+ +L ++ + +I L Q
Sbjct: 4250 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQ----------- 4298
Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430
+Q ++ L + KEL +E+ LEQ+++ +LE I K V+ +
Sbjct: 4299 ------KQKMIEHLNLDDKELVKEQTSHLEQRWF---------QLEDLIKRKIQVSVT-- 4341
Query: 431 LGQDFEHVSVLQEKFS---EFASETGMAGRERL-------AAVNQMVDELIECGHTAAAT 480
+ E ++V+Q +F E+A E E L A N ++D L C A
Sbjct: 4342 ---NLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398
Query: 481 M---AEWKD--------GLNEAWAE-------------LLELMGTRAQLL-AASRELHKF 515
M + KD GLNE L +L+G R + L A E +F
Sbjct: 4399 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQF 4458
Query: 516 FSDARELQGQIEEKRRRL---PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQE 572
+ QI++ R++ + P+ S +T ++ + L+ ++V L
Sbjct: 4459 LMAVFQATSQIQQHERKIMFREHICLLPD---DVSKQVKTCKSAQASLKTYQNEVTGLWA 4515
Query: 573 GAAQLRTVYAGEHAEAIASREQEVLQGWKELLSAC 607
+L + + + QE+ + +L C
Sbjct: 4516 QGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC 4550
Score = 40.4 bits (93), Expect = 0.005
Identities = 67/303 (22%), Positives = 123/303 (40%), Gaps = 24/303 (7%)
Query: 33 KEWLEKIEREGQQLMQEKPELAAS-VRKKLGEIRQCWAELESTTQAKARQLFEASKADQ- 90
K+ L + G+QL Q+ AAS ++ + Q LE K + +A D
Sbjct: 7297 KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQAL-CKQQTSLQAGVLDYE 7355
Query: 91 -LVQSFAELDKKLLHMESQLQDVDPG--GDLATVNSQLKKLQSMESQVEEWYREVGELQA 147
+S L+ ++ E LQ DP DL+T+ ++++L+ + ++ L
Sbjct: 7356 TFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE 7415
Query: 148 QTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWV 207
LPL KE+ +R + + ER L + HQ L+ W+
Sbjct: 7416 LGYRLPLN--DKEI--KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF--LEKCETWM 7469
Query: 208 QERLPLAMQTERGNGLQAV--QQHIKKNQGLRREIQAHGPRLEEVL-----ERAGALASL 260
+ +QTE+ ++ QH+ + Q QA +++L + L
Sbjct: 7470 E----FLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG 7525
Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQELL 319
+ + + L L + W G+ A++R+ ++D+ + Q Y ++AE + WL E L
Sbjct: 7526 QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYL 7585
Query: 320 MMS 322
MS
Sbjct: 7586 PMS 7588
Score = 38.9 bits (89), Expect = 0.016
Identities = 100/569 (17%), Positives = 219/569 (38%), Gaps = 98/569 (17%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82
Q A+L Q E ++I + +++ + V K + +I + ++E + A+
Sbjct: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ-- 2332
Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142
++ + ++ ++ K+L +S + +NS +K S E + +
Sbjct: 2333 ---NETCEALKKVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELE------SL 2378
Query: 143 GELQAQTAALPLEPASKELVGERQNAVGERLVR-LLEPLQERRRLLLASKELHQVAHDLD 201
G +A T + A +L + Q ++ E L + E +QE + L +K + + D
Sbjct: 2379 G--RAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRT 2436
Query: 202 DELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLR 261
+ ++ +L + LQ + + Q + G L L + +
Sbjct: 2437 GDSKVLEAKL---------HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSK-----QIV 2482
Query: 262 SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM 321
S E + + E+ Q A L++ + +Q + D A ++ + ++ W+ E E
Sbjct: 2483 SSIQEQITKANEEFQ---AFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFN 2539
Query: 322 SEDKGKDEQSTLQLLKKHLQLEQGVENY---EESIAQLSRQCRALLEMGHPDSEQISRRQ 378
+E+ G+ +Q + + ++E + ES+ +LS++ + L E GH ++ R
Sbjct: 2540 TENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQE-GRLC 2598
Query: 379 SQVDRLYVALKELGEER----RVALEQQYWLYQLSRQ----VSELEHWIAEKEVVAGSPE 430
SQ+ + L + +E+ +VAL++ L + + V ++ +A E GS +
Sbjct: 2599 SQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKD 2658
Query: 431 -LGQDFEHVSVLQEKFSEFASETGMA---GRERLAAVNQ-------------------MV 467
L + + + E + MA G + L + N+ ++
Sbjct: 2659 TLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIM 2718
Query: 468 DELIECGHTAAATMAEWKD---------------------------GLNEAWAELLELMG 500
+ T + +++W D GL E + L L
Sbjct: 2719 SSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQS 2778
Query: 501 TRAQLLAASRELHKFFSDARELQGQIEEK 529
++ +R LH+ + +REL + E++
Sbjct: 2779 ILSEAEDHTRALHRLIAKSRELYEKTEDE 2807
Score = 37.0 bits (84), Expect = 0.060
Identities = 93/533 (17%), Positives = 203/533 (38%), Gaps = 46/533 (8%)
Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVG--ERQNAVGERLV 174
+++ V++ L+K+Q S+ E ++ + ++ L ++ G + A E
Sbjct: 3096 NISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWK 3155
Query: 175 RLLEPLQERRRLL----LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHI 230
L ++ L + K+ A + D L+ ++ + + + R L A ++
Sbjct: 3156 NFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHES--SNRLYDLPAKRREQ 3213
Query: 231 KKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQ 290
+K Q + EI + P+L + E+A L ++ +++ R + QL S + L + +
Sbjct: 3214 QKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA-ASKSFRHRVSQLSSQYLALSNLTKEKV 3272
Query: 291 QVLD-AAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349
LD + Q+ + E++ W+ + ++ S ++S L L+ V+
Sbjct: 3273 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3332
Query: 350 EE-SIAQLSRQCRALLEMGHPDSEQISRRQSQ-VDRLYVALKELGEERRVALE---QQYW 404
+E + + + ++L+ P+ ++Q Q V ++ +L G + LE ++
Sbjct: 3333 KEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWT 3392
Query: 405 LYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVN 464
YQ V + W+ E +++ + + +E +T M G+ +L
Sbjct: 3393 SYQ--DGVRQFSGWMDSMEA------------NLNESERQHAELRDKTTMLGKAKL---- 3434
Query: 465 QMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQG 524
++E + + T+ G+ E + LEL + + A + + + +L
Sbjct: 3435 --LNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVR 3492
Query: 525 QIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ----EGAAQLRTV 580
+E +R L L H + + +++LQ EG A L +V
Sbjct: 3493 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3552
Query: 581 YAGEH---AEAIASREQEVL----QGWKELLSACEDARLHVSSTADALRFHSQ 626
I E L Q W+ + R ++ + LR Q
Sbjct: 3553 LHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3605
Score = 35.8 bits (81), Expect = 0.13
Identities = 113/552 (20%), Positives = 214/552 (38%), Gaps = 90/552 (16%)
Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 69
E +++HK + F+ EL +E L+K+ + G QL+ E+ A + ++
Sbjct: 2552 EKKNEVHKV----EMFLGELLAARESLDKLSQRG-QLLSEEGHGAGQEGRLCSQLLTSHQ 2606
Query: 70 ELESTTQAKARQ----LFEASKADQLVQSF----AELDKKLLHMESQLQDVDPGGDLATV 121
L T+ K R L E ++ +QS + +L ES L G T+
Sbjct: 2607 NLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTL------GSKDTL 2660
Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 181
+L ++Q + E GE++ A E A + E Q + +L L E
Sbjct: 2661 EKRLSQIQDILLMKGE-----GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWA 2715
Query: 182 E-RRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
+ + A L V +D ER N L+ + + +Q + +
Sbjct: 2716 DIMSSSVHAQSTLESVISQWND-------------YVERKNQLEQWMESV--DQKIEHPL 2760
Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
Q P L+E L S+ S EAE R L +L + ++ E ++ D +F+
Sbjct: 2761 QPQ-PGLKEKFVLLDHLQSILS-EAEDHTRALHRL------IAKSRELYEKTEDESFK-- 2810
Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
D A+ E +++ ++++K + + +++K HL V + + + +
Sbjct: 2811 ----DTAQEELKTQFNDIMTVAKEKMRKVE---EIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
+M DS ++ S++ L + +E+G R +E + + S E
Sbjct: 2864 HRWSDMS-GDSSATQKKLSKIKEL-IDSREIGASRLSRVESLAPEVKQNTTASGCELMHT 2921
Query: 421 EKEVVAGSPELGQD--FEHVSVLQEKFSEFA-SETGMAGR--------ERLAAV------ 463
E + + + +D F+ S L+ S+ A SE +G+ E+ +A+
Sbjct: 2922 EMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQ 2981
Query: 464 -------NQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 516
+E++EC H E D L +A +L +L SR+L +
Sbjct: 2982 QLTLLEGKNTDEEIVECWHKG----QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY- 3036
Query: 517 SDARELQGQIEE 528
+ ++ G I+E
Sbjct: 3037 --SGKVSGLIKE 3046
Score = 34.7 bits (78), Expect = 0.30
Identities = 111/623 (17%), Positives = 239/623 (38%), Gaps = 49/623 (7%)
Query: 38 KIEREGQQLMQEKPELAASVRKKLGEIRQCWAELE----STTQAKARQLFEASKADQLVQ 93
+++R G +L E+P + ++L +++ + EL S + L S+ ++ +Q
Sbjct: 6542 ELKRRGDKLQVEQPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6596
Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 153
A+L +E+ + + GD + S +++Q + + +E+++ + T L
Sbjct: 6597 DLADL------LETGQEKM--AGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLF 6648
Query: 154 LEPASKELVGERQ------NAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWV 207
+ S + E Q L R + E +L L + +L +L V
Sbjct: 6649 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV 6708
Query: 208 QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEA 267
+ +P E + I Q L+ + + P+L +VL+ L L S
Sbjct: 6709 ESSIPSVGLVEENE--DRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL--LISISCSD 6764
Query: 268 VRRGLEQLQSAWAGLREAAERRQQVLDAAFQV-EQYYFDVAEVEAWL-GEQELLMMSEDK 325
+ L QL W + L+ + +Y + A++ WL ++ L +
Sbjct: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ 6824
Query: 326 GKDEQSTLQLLKKHL----QLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQV 381
L++++ HL + + V+ + + LL + D+ + S++
Sbjct: 6825 SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRI 6884
Query: 382 DRLYVALKELGEERRVALEQQYWLYQLSRQ-VSELEHWIAEKEVVAGSPE------LGQD 434
D + L + L Q SR +SE+ WI+ E V E +G
Sbjct: 6885 DSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG-- 6942
Query: 435 FEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAATMAEWKDGLNE 490
++ + +K+ F + + + VNQ V ++ +E + AE +N+
Sbjct: 6943 YKAIHEYLQKYKGFKIDINCK-QLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNK 7001
Query: 491 AWAELLELMGTRAQLLAASRE-LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549
+W L L+ + QLL E ++ ++ + L+ E + +RL + + + S +
Sbjct: 7002 SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNA 7060
Query: 550 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609
+ + E ++ +V ++++ L + + + S +E+ Q W L
Sbjct: 7061 LKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQ 7120
Query: 610 ARLHVSSTADALRFHSQVRDLLS 632
++ + S D H D ++
Sbjct: 7121 LKILLKSVLDQWSSHKVAFDKIN 7143
Score = 33.1 bits (74), Expect = 0.86
Identities = 47/236 (19%), Positives = 102/236 (43%), Gaps = 20/236 (8%)
Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81
++ +M L + ++ ++R +L +E+ L V E Q ++ +A+
Sbjct: 8370 YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET-QTAGVIDRWELLQAQA 8428
Query: 82 LFEASKADQLVQSFAELDKKLLHMES----------QLQDVDPGGDLATVNSQLKKLQSM 131
L + + Q +Q + + + L + + QLQ ++ D+ T+ Q+KKL+ +
Sbjct: 8429 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKEL 8488
Query: 132 ESQVEEWYREVGELQAQTAALPLEPA-SKEL--VGERQNAVGERLVRLLEPLQERRRL-- 186
+ V+ +R+ L + A SKE + +R + + R R+ L+E R L
Sbjct: 8489 QKAVD--HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQ 8546
Query: 187 --LLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
L+ + H+++H L L + R + + + +Q H K+ ++ E+
Sbjct: 8547 DALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 8602
Score = 32.7 bits (73), Expect = 1.1
Identities = 92/467 (19%), Positives = 179/467 (38%), Gaps = 79/467 (16%)
Query: 28 ELAQNKEWLEKIEREGQQLM---QEKPELAASVRKKLGEIRQCWAELESTTQAKA----- 79
+L + KE + E QQL+ +E + S LG+I + LE Q+ A
Sbjct: 795 QLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQK 854
Query: 80 ------------RQLFEASKADQLVQSFAELDKKLLH-----MESQLQDVDPG------- 115
+ L K Q VQ F L L H ++ Q+ D+
Sbjct: 855 HQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKK 914
Query: 116 -GD----LATVNSQLKKLQSMESQVEEWYREVGE-LQAQTAALPLEPASKELVGERQNAV 169
GD + T + +KK + +++E+ R E L+ + L E + V
Sbjct: 915 TGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV 974
Query: 170 GERLVRLLE------PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 223
++ + P QE++ L A ++LH+ DL E + L L + E+ L
Sbjct: 975 LNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPY--HLLHLKIDVEKNRFL 1032
Query: 224 QAVQQ---------HIKKNQGLRREIQAH-------GPR--LEEVLERAGALASLRSPEA 265
+V++ + +G + I+ H GP E+ L+ L ++ P
Sbjct: 1033 ASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELC-VKLPVR 1091
Query: 266 EAVRRGLEQLQSAWAGLREAAERR-QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMS-E 323
+ VR LR A + +++++ + + Y +E +W+ E + +
Sbjct: 1092 DPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIK 1151
Query: 324 DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383
+ D + ++ + ++ GV E+++ L + + L E+ + Q ++ ++ +
Sbjct: 1152 GEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQ--KQGDELAK 1209
Query: 384 LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430
L + K L V L L ++ + +S + KE+V S E
Sbjct: 1210 LSSSFKAL-----VTL-----LSEVEKMLSNFGDCVQYKEIVKNSLE 1246
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 77.0 bits (188), Expect = 5e-14
Identities = 139/658 (21%), Positives = 261/658 (39%), Gaps = 114/658 (17%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
ELA+ + +++E + LMQEK +L V+ AE +S A+ R
Sbjct: 866 ELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ----------AEADSLADAEER------- 908
Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYREVGELQ 146
DQL+++ +L+ K+ + + +D + +N++L K + +E + E +++ +L+
Sbjct: 909 CDQLIKTKIQLEAKIKEVTERAEDEE------EINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206
A + E K + + E + L E + + + A +E HQ LDD
Sbjct: 963 LTLAKVEKE---KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ--QTLDD---- 1013
Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE 266
LQA + + + +++ LE LE + +
Sbjct: 1014 ----------------LQAEEDKVNTLTKAKIKLEQQVDDLEGSLE-----------QEK 1046
Query: 267 AVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMS-EDK 325
+R LE+ + G + A+ ++ +E D +++ L ++E M + K
Sbjct: 1047 KIRMDLERAKRKLEGDLKLAQ------ESTMDIEN---DKQQLDEKLKKKEFEMSGLQSK 1097
Query: 326 GKDEQST-LQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQ 380
+DEQ+ +QL KK +L+ +E EE I + R RA E D E+IS R +
Sbjct: 1098 IEDEQALGMQLQKKIKELQARIEELEEEI-EAERASRAKAEKQRSDLSRELEEISERLEE 1156
Query: 381 VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSV 440
A E+ ++R ++ + + E K+ ELG+ +++
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1216
Query: 441 LQEKFSEFASETGMAGRE---RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLE 497
+++K + SE M + + V++ L + ++E K E + +
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIND 1276
Query: 498 LMGTRAQLLAASRELHKFFSDARELQG-----------QIEEKRRRLPRLTTPPEPRPSA 546
L RA+L S E + + L QIEE +R+L E +
Sbjct: 1277 LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQL------EEEIKAK 1330
Query: 547 SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA----------IASREQEV 596
S++ L++ HD LL Q + QE A+L+ + ++E R +E+
Sbjct: 1331 SALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEEL 1390
Query: 597 LQGWKELLSACEDARLHV--------SSTADALRFHSQVRDLLSWMDGIASQIGAADK 646
+ K+L +DA HV S R ++V DL+ ++ + A DK
Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDK 1448
Score = 42.0 bits (97), Expect = 0.002
Identities = 106/551 (19%), Positives = 221/551 (40%), Gaps = 87/551 (15%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLM---QEKPELAASVRKK-------LGEIRQ----CW 68
+A A+ A ++ ++++ E + LM + A++ KK L E +Q
Sbjct: 1409 EAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1468
Query: 69 AELEST---TQAKARQLFEASKA-DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ 124
AELE++ +++ + +LF+ A ++ + L ++ +++ ++ D+ +A +
Sbjct: 1469 AELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE--QIAEGGKR 1526
Query: 125 LKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERR 184
+ +L+ ++ QVE+ E ELQA AL AS E E
Sbjct: 1527 IHELEKIKKQVEQ---EKSELQA---ALEEAEASLE--------------------HEEG 1560
Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHI-----KKNQGLRRE 239
++L EL+QV ++D ++A E + M+ ++++Q + +N +R +
Sbjct: 1561 KILRIQLELNQVKSEVDRKIAEKDEEID-QMKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1619
Query: 240 IQAHGPRLEEVLE-------RAGALASLRSPEA--EAVRRGLEQLQSAWAGLREA---AE 287
+ G E ++ A AL + R+ +A + + L+ + L+E E
Sbjct: 1620 KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVE 1679
Query: 288 RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVE 347
RR +L A + + + E + EQELL SE L+ +LE +
Sbjct: 1680 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1739
Query: 348 NYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQ 407
+ + + ++ R E + + + + +EL +E+ + +
Sbjct: 1740 QIQGEMEDIIQEARNAEE----------KAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789
Query: 408 LSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAV---- 463
L + V +L+H + E E +A L + + L+ + E E + + AV
Sbjct: 1790 LEQTVKDLQHRLDEAEQLA----LKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845
Query: 464 --NQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARE 521
+ V EL + +D +++ A ++ + Q A + + S R
Sbjct: 1846 KHERKVKELTYQTEEDRKNILRLQDLVDKLQA---KVKSYKRQAEEAEEQSNVNLSKFRR 1902
Query: 522 LQGQIEEKRRR 532
+Q ++EE R
Sbjct: 1903 IQHELEEAEER 1913
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 75.1 bits (183), Expect = 2e-13
Identities = 135/657 (20%), Positives = 263/657 (40%), Gaps = 112/657 (17%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEA-S 86
ELA+++ +++E + L+QEK +L V QA++ L +A
Sbjct: 863 ELAKSEAKRKELEEKLVTLVQEKNDLQLQV------------------QAESENLLDAEE 904
Query: 87 KADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYREVGEL 145
+ DQL+++ +L+ K+ + + +D + +N++L K + +E + E +++ +L
Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEE------EINAELTAKKRKLEDECSELKKDIDDL 958
Query: 146 QAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELA 205
+ A + E K + + E L L E + + R A +E HQ A LDD
Sbjct: 959 ELTLAKVEKE---KHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQA--LDD--- 1010
Query: 206 WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEA 265
LQA + + + +++ LE LE+ L +
Sbjct: 1011 -----------------LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKL----RVDL 1049
Query: 266 EAVRRGLE-QLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 324
E +R LE L+ A + + +QQ LD + + + + +
Sbjct: 1050 ERNKRKLEGDLKLAQESILDLENDKQQ-LDERLKKKDFEY---------------CQLQS 1093
Query: 325 KGKDEQST-LQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQS 379
K +DEQ+ LQ KK +L+ +E EE I + R RA E D E++S R
Sbjct: 1094 KVEDEQTLGLQFQKKIKELQARIEELEEEI-EAERATRAKTEKQRSDYARELEELSERLE 1152
Query: 380 QVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEH----WIAEKEVVAGSPELGQDF 435
+ + EL ++R E ++ + + + L+H K+ ELG+
Sbjct: 1153 EAGGVTSTQIELNKKR----EAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI 1208
Query: 436 EHVSVLQEKFSEFASETGMAGRE---RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAW 492
+++ +++K + SE + + + +V++ L + T ++E + E
Sbjct: 1209 DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ 1268
Query: 493 AELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP-----PEPRPSAS 547
L EL +++L + EL + + + Q+ ++ + T E + +
Sbjct: 1269 RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKN 1328
Query: 548 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA----------IASREQEVL 597
++ L++ HD LL Q + QEG A+L+ + ++E R +E+
Sbjct: 1329 ALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELE 1388
Query: 598 QGWKELLSACEDARLHV--------SSTADALRFHSQVRDLLSWMDGIASQIGAADK 646
+ K+L +D+ V S R +V DL+ ++ S A DK
Sbjct: 1389 EAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 1445
Score = 59.3 bits (142), Expect = 1e-08
Identities = 123/559 (22%), Positives = 220/559 (39%), Gaps = 100/559 (17%)
Query: 26 MAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEA 85
+A+L + K+ L++ ++ +Q + + S+ K ++ Q +LES+ + + + +
Sbjct: 990 IAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDL 1049
Query: 86 SKADQLVQSFAEL-DKKLLHMESQLQDVDPGGDLATVNSQLKKLQ----SMESQVEEWYR 140
+ + ++ +L + +L +E+ Q +D +LKK ++S+VE+
Sbjct: 1050 ERNKRKLEGDLKLAQESILDLENDKQQLD---------ERLKKKDFEYCQLQSKVED--- 1097
Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ-ERRRLLLASKELHQVAHD 199
QT L + KEL R+ L E ++ ER K+ A +
Sbjct: 1098 ------EQTLGLQFQKKIKELQA--------RIEELEEEIEAERATRAKTEKQRSDYARE 1143
Query: 200 LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQG-----LRREIQAHGPRLEEVLERA 254
L++ + ERL E G+ + Q + K + LRR+++ E L+
Sbjct: 1144 LEE----LSERL------EEAGGVTSTQIELNKKREAEFLKLRRDLE------EATLQHE 1187
Query: 255 GALASLRSPEAEAVRRGLEQ---LQSAWAGL-REAAERRQQVLDAAFQVEQYYFDVAEVE 310
+A+LR A++V EQ LQ L +E +E + ++ D + +E A +E
Sbjct: 1188 AMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLE 1247
Query: 311 AWLGEQELLMMSEDKGKDEQ-----STLQLLKKHLQLEQG-----VENYEESIAQLSRQC 360
E +SE +GK+E+ S L K LQ E G +E E ++QLSR
Sbjct: 1248 KICRTLED-QLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSK 1306
Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQ---------LSRQ 411
+A + Q+ + L AL+ + + L +QY Q LS+
Sbjct: 1307 QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL-LREQYEEEQEGKAELQRALSKA 1365
Query: 412 VSELEHWIAEKEVVA---------GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462
SE+ W + E A +L Q + E + + +
Sbjct: 1366 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGE 1425
Query: 463 VNQMVDELIECGHTAAA----------TMAEWKDGLNEAWAELLELMGTRAQLLAASREL 512
V ++ ++ AAA +AEWK E+ AEL + L S EL
Sbjct: 1426 VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSL---STEL 1482
Query: 513 HKFFSDARELQGQIEEKRR 531
K + E Q+E +R
Sbjct: 1483 FKLKNAYEEALDQLETVKR 1501
Score = 49.7 bits (117), Expect = 9e-06
Identities = 90/408 (22%), Positives = 167/408 (40%), Gaps = 56/408 (13%)
Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95
LE ++RE + L QE A + +++ E + ELE K+R+ E KAD + +
Sbjct: 1496 LETVKRENKNLEQE----IADLTEQIAENGKTIHELE-----KSRKQIELEKAD-IQLAL 1545
Query: 96 AELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYREVGE-LQAQTAALP 153
E + L H E+++ + +L V S++ +K+ + ++E+ R ++ +AL
Sbjct: 1546 EEAEAALEHEEAKILRIQL--ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603
Query: 154 LEPASK-ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERL- 211
E S+ E + ++ G+ ++ R+ K L V L D + + L
Sbjct: 1604 AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALR 1663
Query: 212 -------PLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE 264
LA+ R N LQA + ++ L + +A +E+L+ + L +
Sbjct: 1664 GQEDLKEQLAIVERRANLLQAEVEELRAT--LEQTERARKLAEQELLDSNERVQLLHTQN 1721
Query: 265 AEAVRR------GLEQLQS----AWAGLREAAER-RQQVLDAAFQVEQYYFD-------- 305
+ L QLQS A R A E+ ++ + DAA E+ +
Sbjct: 1722 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1781
Query: 306 ---------VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 356
V +++ L E E L + K + ++ ++ + +LE + ES+ L
Sbjct: 1782 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGL 1841
Query: 357 ---SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401
R+ + L D + + R Q VD+L V +K + A EQ
Sbjct: 1842 RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQ 1889
Score = 48.1 bits (113), Expect = 3e-05
Identities = 94/437 (21%), Positives = 169/437 (38%), Gaps = 70/437 (16%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLM---QEKPELAASVRKKLGEIRQCWAELESTTQAKA 79
+A A+ A ++ ++++ E + LM + LAA++ KK + AE ++ +
Sbjct: 1406 EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQ 1465
Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQS----MESQV 135
+L + K + + + EL K E L ++ TV + K L+ + Q+
Sbjct: 1466 AELEASLKESRSLST--ELFKLKNAYEEALDQLE------TVKRENKNLEQEIADLTEQI 1517
Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQ 195
E + + EL+ + LE A +L E A E E ++L EL Q
Sbjct: 1518 AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEH---------EEAKILRIQLELTQ 1568
Query: 196 VAHDLDDELAWVQERLPL--------------AMQTERGNGLQAVQQHIKKNQGLRREIQ 241
V ++D ++A E + A+ E + +A++ KK +G EI+
Sbjct: 1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLK-KKMEGDLNEIE 1627
Query: 242 ---AHGPRLEEVLERAGALASLRSPEAEA---------VRRGLEQLQSAWAGLREAAERR 289
+H R + A L LRS + + RG E L+ A ERR
Sbjct: 1628 IQLSHANR-----QAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLA----IVERR 1678
Query: 290 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349
+L A + + + E L EQELL +E L+ +LE +
Sbjct: 1679 ANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQL 1738
Query: 350 EESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLS 409
+ + SR R E + + + + +EL +E+ + + L
Sbjct: 1739 QSEVEDASRDARNAEE----------KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 1788
Query: 410 RQVSELEHWIAEKEVVA 426
+ V +L+H + E E +A
Sbjct: 1789 QTVKDLQHRLDEAEQLA 1805
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 74.7 bits (182), Expect = 3e-13
Identities = 132/642 (20%), Positives = 256/642 (39%), Gaps = 112/642 (17%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
ELA+ + +++E + LMQEK +L V+ AE ++ A+ R
Sbjct: 866 ELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ----------AEADALADAEER------- 908
Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYREVGELQ 146
DQL+++ +L+ K+ + + +D + +N++L K + +E + E +++ +L+
Sbjct: 909 CDQLIKTKIQLEAKIKEVTERAEDEE------EINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206
A + E K + + E + L E + + + A +E HQ LDD
Sbjct: 963 LTLAKVEKE---KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ--QTLDD---- 1013
Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE 266
L M+ ++ N L + +++ LE LE+ L + E
Sbjct: 1014 ------LQMEEDKVNTLTKA----------KTKLEQQVDDLEGSLEQEKKLCM----DLE 1053
Query: 267 AVRRGLE-QLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
+R LE L+ A + +QQ+ + ++++ F+++ ++ + +++ L
Sbjct: 1054 RAKRKLEGDLKLAQESTMDTENDKQQLNE---KLKKKEFEMSNLQGKIEDEQAL------ 1104
Query: 326 GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQV 381
+QL KK +L+ +E EE I + R RA E D E+IS R +
Sbjct: 1105 ------AIQLQKKIKELQARIEELEEEI-EAERASRAKAEKQRSDLSRELEEISERLEEA 1157
Query: 382 DRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL 441
A E+ ++R ++ + S E K+ ELG+ + + +
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRV 1217
Query: 442 QEKFSEFASETGMAGRE---RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL 498
++K + SE M + + V++ + T ++E K E + EL
Sbjct: 1218 KQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINEL 1277
Query: 499 MGTRAQLLAASRELHKFFSD-----------ARELQGQIEEKRRRLPRLTTPPEPRPSAS 547
+A+L S E + + + QIEE +R+L E + S
Sbjct: 1278 SAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL------EEETKAKS 1331
Query: 548 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA----------IASREQEVL 597
++ L++ HD LL Q + QE A+L+ + ++E R +E+
Sbjct: 1332 TLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELE 1391
Query: 598 QGWKELLSACEDARLHVSSTADAL--------RFHSQVRDLL 631
+ K+L +DA HV + R ++V DL+
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLM 1433
Score = 47.4 bits (111), Expect = 4e-05
Identities = 102/525 (19%), Positives = 211/525 (40%), Gaps = 68/525 (12%)
Query: 39 IEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK--------ADQ 90
+ + ++ + K EL + K E+ Q + E+ + +L EA K A++
Sbjct: 1347 LREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1406
Query: 91 LVQSF----AELDKKLLHMESQLQD--VDPGGDLATVNSQLKKLQSMESQVEEWYREVGE 144
V++ A L+K ++++++D +D A + KK ++ + + EW ++ E
Sbjct: 1407 HVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEE 1466
Query: 145 LQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDE 203
QA+ A E S + + +NA E L L L +K L Q DL ++
Sbjct: 1467 TQAELEASQKESRSLSTELFKVKNAYEESLDHL-------ETLKRENKNLQQEISDLTEQ 1519
Query: 204 LAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP 263
+A E G +HI + + +++++ L+ LE A ASL
Sbjct: 1520 IA------------EGG-------KHIHELEKVKKQLDHEKSELQTSLEEAE--ASLEHE 1558
Query: 264 EAEAVRRGLEQLQSAWAGLREAAERRQ---QVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320
E + +R LE Q R+ AE+ + Q+ +V + + E L +
Sbjct: 1559 EGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRI 1618
Query: 321 MSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380
+ +G + +QL + Q + + N + L + + L+ + + + +
Sbjct: 1619 KKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGIL-KDTQLHLDDAIRGQDDLKEQLAM 1677
Query: 381 VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV----------VAGSPE 430
V+R ++ EE R +LE+ + R+++E E A + V + +
Sbjct: 1678 VERRANLMQAEVEELRASLERT----ERGRKMAEQELLDASERVQLLHTQNTSLINTKKK 1733
Query: 431 LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ--MVDELIECGHTAAATMAEWKDGL 488
L D +S +Q + + E A + A+ M+ E ++ +A + K +
Sbjct: 1734 LETD---ISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1790
Query: 489 NEAWAELLELMGTRAQLL--AASRELHKFFSDARELQGQIEEKRR 531
+ +L + QL +++ K + REL+ ++E +++
Sbjct: 1791 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQK 1835
Score = 36.2 bits (82), Expect = 0.10
Identities = 94/452 (20%), Positives = 182/452 (40%), Gaps = 71/452 (15%)
Query: 59 KKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL 118
K L E +Q + E ++ +A ++ S + +L + ++ L H+E+ L
Sbjct: 1455 KVLAEWKQKYEETQAELEASQKE--SRSLSTELFKVKNAYEESLDHLET----------L 1502
Query: 119 ATVNSQLKK-LQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLL 177
N L++ + + Q+ E + + EL+ L E + + E A E
Sbjct: 1503 KRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEH----- 1557
Query: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQ--------QH 229
E ++L EL+QV ++D ++A E L Q +R N L+ V+ +
Sbjct: 1558 ----EEGKILRIQLELNQVKSEIDRKIAEKDEELD---QLKR-NHLRVVESMQSTLDAEI 1609
Query: 230 IKKNQGLRREIQAHGPRLEEVLE-------RAGALASLRSPEA---------EAVRRGLE 273
+N LR + + G E ++ A AL +LR+ + + RG +
Sbjct: 1610 RSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQD 1669
Query: 274 QLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTL 333
L+ A ERR ++ A + + + E + EQELL SE
Sbjct: 1670 DLKEQLA----MVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNT 1725
Query: 334 QLLKKHLQLEQGVENYE---ESIAQLSRQCRALLEMGHPD----SEQISRRQ---SQVDR 383
L+ +LE + + E I Q +R + D +E++ + Q + ++R
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 384 LYVALKELGEERRVALE--QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL 441
+ +++ ++ ++ L+ +Q L +Q+ +LE + E E S E + E V L
Sbjct: 1786 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVES-EQKHNVEAVKGL 1844
Query: 442 ---QEKFSEFASETGMAGRERLAAVNQMVDEL 470
+ + E +T R+ + + +VD+L
Sbjct: 1845 RKHERRVKELTYQT-EEDRKNILRLQDLVDKL 1875
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 73.9 bits (180), Expect = 4e-13
Identities = 136/663 (20%), Positives = 263/663 (39%), Gaps = 114/663 (17%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82
Q ELA+++ +++E + L++EK +L V+ AE E A+ R
Sbjct: 863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ----------AEAEGLADAEER-- 910
Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYRE 141
DQL+++ +L+ K+ + + +D + +N++L K + +E + E ++
Sbjct: 911 -----CDQLIKTKIQLEAKIKEVTERAEDEE------EINAELTAKKRKLEDECSELKKD 959
Query: 142 VGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLD 201
+ +L+ A + E K + + E + L E + + + A +E HQ LD
Sbjct: 960 IDDLELTLAKVEKE---KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ--QTLD 1014
Query: 202 DELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLR 261
D LQA + + + +++ LE LE+ L
Sbjct: 1015 D--------------------LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-- 1052
Query: 262 SPEAEAVRRGLE-QLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320
+ E +R LE L+ A + + +QQ+ + ++++ F+++ +++
Sbjct: 1053 --DLERAKRKLEGDLKLAQESIMDIENEKQQLDE---KLKKKEFEISNLQS--------- 1098
Query: 321 MSEDKGKDEQST-LQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQIS 375
K +DEQ+ +QL KK +L+ +E EE I + R RA E D E+IS
Sbjct: 1099 ----KIEDEQALGIQLQKKIKELQARIEELEEEI-EAERASRAKAEKQRSDLSRELEEIS 1153
Query: 376 RRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDF 435
R + A E+ ++R ++ + + E K+ ELG+
Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213
Query: 436 EHVSVLQEKFSEFASETGMAGRE---RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAW 492
+++ +++K + SE M + + V++ L + T ++E K E
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273
Query: 493 AELLELMGTRAQLLAASRELHKFFSDARELQG-----------QIEEKRRRLPRLTTPPE 541
+ +L R +L S E + + L QIEE +R+L E
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL------EE 1327
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA----------IAS 591
+ +++ L++ HD LL Q + QE A+L+ + + E
Sbjct: 1328 EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQ 1387
Query: 592 REQEVLQGWKELLSACEDARLHV--------SSTADALRFHSQVRDLLSWMDGIASQIGA 643
R +E+ + K+L + A HV S R ++V DL+ ++ + A
Sbjct: 1388 RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA 1447
Query: 644 ADK 646
DK
Sbjct: 1448 LDK 1450
Score = 57.0 bits (136), Expect = 6e-08
Identities = 107/539 (19%), Positives = 221/539 (41%), Gaps = 74/539 (13%)
Query: 29 LAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK- 87
L ++ + + + ++ + K EL ++ K E+ Q + E+ + +L EA K
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398
Query: 88 -------ADQLVQSF----AELDKKLLHMESQLQDV--DPGGDLATVNSQLKKLQSMESQ 134
A++ V++ A L+K ++++++D+ D A + KK ++ +
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI 1458
Query: 135 VEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLL----EPLQERRRLLLAS 190
+ EW ++ E A+ LE + KE ++G L ++ E L + L +
Sbjct: 1459 LAEWKQKCEETHAE-----LEASQKEA-----RSLGTELFKIKNAYEESLDQLETLKREN 1508
Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
K L Q DL +++A E G + +++ K+ + + E+QA LEE
Sbjct: 1509 KNLQQEISDLTEQIA------------EGGKRIHELEKIKKQVEQEKCELQA---ALEE- 1552
Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA---FQVEQYYFDVA 307
A ASL E + +R LE Q R+ AE+ +++ ++ +
Sbjct: 1553 -----AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL 1607
Query: 308 EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG 367
+ E + + + +G + +QL + + + NY + L + + L+
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL-KDTQIHLDDA 1666
Query: 368 HPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV--- 424
E + + + V+R L+ EE R LEQ + SR+++E E A + V
Sbjct: 1667 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT----ERSRKIAEQELLDASERVQLL 1722
Query: 425 -------VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ--MVDELIECGH 475
+ +L D +S +Q + + E A + A+ M+ E ++
Sbjct: 1723 HTQNTSLINTKKKLETD---ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLL--AASRELHKFFSDARELQGQIEEKRRR 532
+A + K + + +L + QL +++ K + REL+G++E +++R
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1838
Score = 34.7 bits (78), Expect = 0.30
Identities = 103/498 (20%), Positives = 209/498 (41%), Gaps = 81/498 (16%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLM---QEKPELAASVRKK-------LGEIRQ----CW 68
+A A+ A ++ ++++ E + LM + A++ KK L E +Q
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470
Query: 69 AELESTTQAKAR----QLFEASKA-DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNS 123
AELE++ Q +AR +LF+ A ++ + L ++ +++ ++ D+ +A
Sbjct: 1471 AELEAS-QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE--QIAEGGK 1527
Query: 124 QLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183
++ +L+ ++ QVE+ E ELQA AL AS E E
Sbjct: 1528 RIHELEKIKKQVEQ---EKCELQA---ALEEAEASLE--------------------HEE 1561
Query: 184 RRLLLASKELHQVAHDLDDELAWVQE----------RLPLAMQTERGNGLQAVQQHIKKN 233
++L EL+QV ++D ++A E R+ +MQ+ +++ I+
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1621
Query: 234 QGLRREIQAHGPRLEEVLERAG-ALASLRSPEA--EAVRRGLEQLQSAWAGLREA---AE 287
+ + ++ +L A AL + R+ + + + L+ + L+E E
Sbjct: 1622 KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVE 1681
Query: 288 RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVE 347
RR +L A + + + E + EQELL SE L+ +LE +
Sbjct: 1682 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1741
Query: 348 NYE---ESIAQLSRQCRALLEMGHPD----SEQISRRQ---SQVDRLYVALKELGEERRV 397
+ E I Q +R + D +E++ + Q + ++R+ +++ ++ ++
Sbjct: 1742 QMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQL 1801
Query: 398 ALE--QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL---QEKFSEFASET 452
L+ +Q L +Q+ +LE + E E S E ++ E V L + + E +T
Sbjct: 1802 RLDEAEQLALKGGKKQIQKLEARVRELEGEVES-EQKRNAEAVKGLRKHERRVKELTYQT 1860
Query: 453 GMAGRERLAAVNQMVDEL 470
R+ + + +VD+L
Sbjct: 1861 -EEDRKNILRLQDLVDKL 1877
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 73.9 bits (180), Expect = 4e-13
Identities = 136/663 (20%), Positives = 263/663 (39%), Gaps = 114/663 (17%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82
Q ELA+++ +++E + L++EK +L V+ AE E A+ R
Sbjct: 863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ----------AEAEGLADAEER-- 910
Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYRE 141
DQL+++ +L+ K+ + + +D + +N++L K + +E + E ++
Sbjct: 911 -----CDQLIKTKIQLEAKIKEVTERAEDEE------EINAELTAKKRKLEDECSELKKD 959
Query: 142 VGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLD 201
+ +L+ A + E K + + E + L E + + + A +E HQ LD
Sbjct: 960 IDDLELTLAKVEKE---KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ--QTLD 1014
Query: 202 DELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLR 261
D LQA + + + +++ LE LE+ L
Sbjct: 1015 D--------------------LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-- 1052
Query: 262 SPEAEAVRRGLE-QLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320
+ E +R LE L+ A + + +QQ+ + ++++ F+++ +++
Sbjct: 1053 --DLERAKRKLEGDLKLAQESIMDIENEKQQLDE---KLKKKEFEISNLQS--------- 1098
Query: 321 MSEDKGKDEQST-LQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQIS 375
K +DEQ+ +QL KK +L+ +E EE I + R RA E D E+IS
Sbjct: 1099 ----KIEDEQALGIQLQKKIKELQARIEELEEEI-EAERASRAKAEKQRSDLSRELEEIS 1153
Query: 376 RRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDF 435
R + A E+ ++R ++ + + E K+ ELG+
Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213
Query: 436 EHVSVLQEKFSEFASETGMAGRE---RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAW 492
+++ +++K + SE M + + V++ L + T ++E K E
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273
Query: 493 AELLELMGTRAQLLAASRELHKFFSDARELQG-----------QIEEKRRRLPRLTTPPE 541
+ +L R +L S E + + L QIEE +R+L E
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL------EE 1327
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA----------IAS 591
+ +++ L++ HD LL Q + QE A+L+ + + E
Sbjct: 1328 EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQ 1387
Query: 592 REQEVLQGWKELLSACEDARLHV--------SSTADALRFHSQVRDLLSWMDGIASQIGA 643
R +E+ + K+L + A HV S R ++V DL+ ++ + A
Sbjct: 1388 RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA 1447
Query: 644 ADK 646
DK
Sbjct: 1448 LDK 1450
Score = 57.0 bits (136), Expect = 6e-08
Identities = 107/539 (19%), Positives = 221/539 (41%), Gaps = 74/539 (13%)
Query: 29 LAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK- 87
L ++ + + + ++ + K EL ++ K E+ Q + E+ + +L EA K
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398
Query: 88 -------ADQLVQSF----AELDKKLLHMESQLQDV--DPGGDLATVNSQLKKLQSMESQ 134
A++ V++ A L+K ++++++D+ D A + KK ++ +
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI 1458
Query: 135 VEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLL----EPLQERRRLLLAS 190
+ EW ++ E A+ LE + KE ++G L ++ E L + L +
Sbjct: 1459 LAEWKQKCEETHAE-----LEASQKEA-----RSLGTELFKIKNAYEESLDQLETLKREN 1508
Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250
K L Q DL +++A E G + +++ K+ + + E+QA LEE
Sbjct: 1509 KNLQQEISDLTEQIA------------EGGKRIHELEKIKKQVEQEKCELQA---ALEE- 1552
Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA---FQVEQYYFDVA 307
A ASL E + +R LE Q R+ AE+ +++ ++ +
Sbjct: 1553 -----AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL 1607
Query: 308 EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG 367
+ E + + + +G + +QL + + + NY + L + + L+
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL-KDTQIHLDDA 1666
Query: 368 HPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV--- 424
E + + + V+R L+ EE R LEQ + SR+++E E A + V
Sbjct: 1667 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT----ERSRKIAEQELLDASERVQLL 1722
Query: 425 -------VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ--MVDELIECGH 475
+ +L D +S +Q + + E A + A+ M+ E ++
Sbjct: 1723 HTQNTSLINTKKKLETD---ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLL--AASRELHKFFSDARELQGQIEEKRRR 532
+A + K + + +L + QL +++ K + REL+G++E +++R
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1838
Score = 34.7 bits (78), Expect = 0.30
Identities = 103/498 (20%), Positives = 209/498 (41%), Gaps = 81/498 (16%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLM---QEKPELAASVRKK-------LGEIRQ----CW 68
+A A+ A ++ ++++ E + LM + A++ KK L E +Q
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470
Query: 69 AELESTTQAKAR----QLFEASKA-DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNS 123
AELE++ Q +AR +LF+ A ++ + L ++ +++ ++ D+ +A
Sbjct: 1471 AELEAS-QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE--QIAEGGK 1527
Query: 124 QLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183
++ +L+ ++ QVE+ E ELQA AL AS E E
Sbjct: 1528 RIHELEKIKKQVEQ---EKCELQA---ALEEAEASLE--------------------HEE 1561
Query: 184 RRLLLASKELHQVAHDLDDELAWVQE----------RLPLAMQTERGNGLQAVQQHIKKN 233
++L EL+QV ++D ++A E R+ +MQ+ +++ I+
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1621
Query: 234 QGLRREIQAHGPRLEEVLERAG-ALASLRSPEA--EAVRRGLEQLQSAWAGLREA---AE 287
+ + ++ +L A AL + R+ + + + L+ + L+E E
Sbjct: 1622 KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVE 1681
Query: 288 RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVE 347
RR +L A + + + E + EQELL SE L+ +LE +
Sbjct: 1682 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1741
Query: 348 NYE---ESIAQLSRQCRALLEMGHPD----SEQISRRQ---SQVDRLYVALKELGEERRV 397
+ E I Q +R + D +E++ + Q + ++R+ +++ ++ ++
Sbjct: 1742 QMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQL 1801
Query: 398 ALE--QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL---QEKFSEFASET 452
L+ +Q L +Q+ +LE + E E S E ++ E V L + + E +T
Sbjct: 1802 RLDEAEQLALKGGKKQIQKLEARVRELEGEVES-EQKRNAEAVKGLRKHERRVKELTYQT 1860
Query: 453 GMAGRERLAAVNQMVDEL 470
R+ + + +VD+L
Sbjct: 1861 -EEDRKNILRLQDLVDKL 1877
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 70.5 bits (171), Expect = 5e-12
Identities = 140/625 (22%), Positives = 248/625 (39%), Gaps = 59/625 (9%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
EL + E+ E + +Q +E L V+ + RQ EL S +A+A E +
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 88 ADQLVQSFA----ELDKKLLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQV 135
A Q ++ E +++L E + L+ + A + S+ +Q+
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQL 1592
Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELH 194
E +E AQ A ++ ER ER L R E RL L ++E+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652
Query: 195 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 254
Q E +E + QAV+Q Q L ++ Q ++ L
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712
Query: 255 GALASLRSP--EAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 312
L LR+ + E R+ LE+ + AA +++Q L+A ++A+V A
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---------ELAKVRA- 1762
Query: 313 LGEQELLMMSEDKGKDE-QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD- 370
E E+L+ S+ + ++E +ST + K+ L+ E G + E +A+ + + RAL E
Sbjct: 1763 --EMEVLLASKARAEEESRSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQR 1817
Query: 371 ---SEQISRRQSQVDRLYVA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426
E +R++++ +R+ L +GE R+ E + L + + L +AE E
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQ 1876
Query: 427 GSPELGQDFEHVSVLQEKF--------SEFASETGMAGRERLAAVNQMVDELIECGHT-- 476
Q +H + ++E+ SE + G+ + L Q+ +E++ +
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFE 1935
Query: 477 -AAATMAEWKDGLNEAWA---------ELLELMGTRAQLLAASRELHKFFSDARELQGQI 526
AAA AE + L + E EL R + LAA E + ++ R +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 527 EEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586
E+ R E + ++ R E Q Q++ QE A + HA
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055
Query: 587 EAIASREQEVLQGWKELLSACEDAR 611
A+ +EQE+ Q ++ S + R
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLR 2080
Score = 64.7 bits (156), Expect = 3e-10
Identities = 131/640 (20%), Positives = 245/640 (38%), Gaps = 106/640 (16%)
Query: 37 EKIEREGQQLMQEK---PELAASVRKK-LGEIRQCWAELESTTQAKARQLFEASKADQLV 92
E+ RE ++ +Q+ E AA RK L E+ + A++E + + R E+++ QL
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152
Q A+ +LQ + A + + Q+++ + + GE +A A
Sbjct: 2040 QEAAQ---------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 153 PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 212
E + ER+ A R V E L++ ++ Q A E+L
Sbjct: 2091 E-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----------AEKLR 2139
Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS------LRSPEAE 266
+ E QA Q +++ Q E++ H E+ L + + L+ E +
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 267 AVRRGL-EQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
+ L E+LQ A EAA +R QV + F V ++++++A + + ++ DK
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259
Query: 326 GKDEQSTLQLLKKHLQLEQGVENY--------------EESIAQ---------------- 355
++ + +K Q+ + EE +AQ
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2319
Query: 356 -----LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE--LGEERRVALEQQYWLYQL 408
L + L + EQ R Q +++ L E G +R + E+Q L ++
Sbjct: 2320 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EM 2378
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468
S + L+ +AE E +D + E+ E T +A +E++ V +
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 469 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 528
+ + H A + L EA AEL RE K +A+ LQ + EE
Sbjct: 2437 QRQQSDHDA--------ERLREAIAEL-------------EREKEKLQQEAKLLQLKSEE 2475
Query: 529 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 588
+ + Q ++F + L+ + R +++ A+L ++ E A+A
Sbjct: 2476 MQ--------TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 589 IASRE------QEVLQGWKELLSACEDARLHVSSTADALR 622
RE Q++ Q + L+++ E+AR + +R
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Score = 63.9 bits (154), Expect = 5e-10
Identities = 134/617 (21%), Positives = 247/617 (40%), Gaps = 51/617 (8%)
Query: 9 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 68
+E + +R Q AE+ + + ++ E ++++ PE + + E+
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTL 1071
Query: 69 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 128
+LE A L + +++ ++ L E QL++ V + L +L
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ------AVPATLPEL 1125
Query: 129 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGER-QNAVGERLVRL------LEPLQ 181
++ ++ +++ + Q AL E + VGER Q GER V + + L
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185
Query: 182 ERRRLLLAS-----KELHQVAHDL-------DDELAWVQE--RLPLAMQTERGNGLQAVQ 227
ER + +LA +EL Q+ L D AW+Q+ R +Q QAV+
Sbjct: 1186 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1245
Query: 228 QHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLRE 284
+ +++ Q L EI+ HG ++EE A + +++ E + V + LE + S A +
Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPK 1304
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341
+ V+ + +Y ++ + + + L M E++ EQ + ++ +
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401
+E +E + +A+ Q +A E + +Q R Q +V R A + +++R E+
Sbjct: 1365 VEAALEK-QRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE 1421
Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLA 461
L QL RQ SE E ++ A + E + V++ + + G A E L
Sbjct: 1422 ---LQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQ 1476
Query: 462 AVNQMVDEL----IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517
A+ +E + A + +D +EL A+RE +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577
EL+ Q EE RRL R R +++ R+ E +LQ S+ E AQL
Sbjct: 1537 ALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAELQ---SKRASFAEKTAQL 1592
Query: 578 RTVYAGEHAEAIASREQ 594
EH RE+
Sbjct: 1593 ERSLQEEHVAVAQLREE 1609
Score = 61.6 bits (148), Expect = 2e-09
Identities = 160/718 (22%), Positives = 285/718 (39%), Gaps = 134/718 (18%)
Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLE----KIEREGQQLMQEKPELAASVRKKL 61
+GT + + +R +A + Q ++ LE +++RE Q++ EL A
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA------ 1755
Query: 62 GEIRQCWAELESTTQAKARQLFE----ASKADQLVQS----FAELDKKLLHMESQLQDVD 113
E+ + AE+E +KAR E + K+ Q +++ F EL ++ + + ++
Sbjct: 1756 -ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERL 173
LA ++ ++ ++ E + E +GE A E A KE + A ERL
Sbjct: 1815 RQRQLAEEDAARQRAEA-ERVLAEKLAAIGE--ATRLKTEAEIALKE-----KEAENERL 1866
Query: 174 VRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKN 233
RL E +RR L H+ D+++ LA Q R + ER GL V+ +++
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKA--DIEERLA--QLRKASDSELERQKGL--VEDTLRQR 1920
Query: 234 QGLRREI--------QAHGPRLEEVLE----RAGALASLRSPE-------------AEAV 268
+ + EI +A + E LE R+ A +LRS E AE
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 269 RR---GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
RR E++Q + A EAA +R+ L+ +VE+ V E E ++
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALE---EVERLKAKVEEARRLRERAE-----QES 2032
Query: 326 GKDEQSTLQLLKKHLQLEQ-----GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380
+ Q + +K LQ E+ V+ E+ + Q +Q +++L+ ++E R +
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 381 VDRLYV-----------------ALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423
+ V LK+ EE+ A Q + R+ +E E A +
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---AARR 2149
Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH-------- 475
A L Q + EK +FA +T + + + +L E H
Sbjct: 2150 AQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 476 ---------TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL--------HKFFSD 518
AA ++ ++ L ++ EL +A++ A +R L +F +
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268
Query: 519 ARELQGQIEEKRRRL-------PRLTTPPE-----PRPSASSM-QRTLRAFEHDLQLLV- 564
E Q+ E+ RL RL E R A M + ++A + +L
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2328
Query: 565 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622
+++ Q Q+ AQ + E E +A + E QG++ L A +L +S+ A+ L+
Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Score = 58.9 bits (141), Expect = 1e-08
Identities = 130/625 (20%), Positives = 238/625 (38%), Gaps = 123/625 (19%)
Query: 18 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 76
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 293 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 351
Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 352 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 399
Query: 137 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ E G + E+L + LQ RLL A K + Q
Sbjct: 400 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 434
Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 254
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 435 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 480
Query: 255 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 481 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 532
Query: 314 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 581
Query: 374 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 582 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 636
Query: 426 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 637 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 693
Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 694 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 745
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 598
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 746 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 796
Query: 599 --------GWKELLSACEDARLHVS 615
G LL+ C+ ++ V+
Sbjct: 797 RHPAHPMRGRLPLLAVCDYKQVEVT 821
Score = 52.4 bits (124), Expect = 1e-06
Identities = 107/433 (24%), Positives = 179/433 (41%), Gaps = 65/433 (15%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
+LAQ + EK+ +E Q +QE L A E+ Q EL Q +AR+L E
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAE-----AELLQQQKEL---AQEQARRLQE--D 2349
Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147
+Q+ Q AE E+Q G T+ ++ ++ M ++ E V E+ +
Sbjct: 2350 KEQMAQQLAE--------ETQ-------GFQRTLEAERQRQLEMSAEAERLKLRVAEM-S 2393
Query: 148 QTAALPLEPASK-----ELVGE---RQNAVGERLVRLLEPLQERR--------RLLLASK 191
+ A E A + E +GE R + V L++ L+ +R RL A
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453
Query: 192 ELHQVAHDLDDELAWVQ---ERLPLAMQTERGNGLQAVQQHI--KKNQGLRRE--IQAHG 244
EL + L E +Q E + Q + QA+QQ +K+ L+RE I+
Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304
+LE++ + A A E + ++ +EQ + E A RRQ +A V +
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH--EAEEGVRRKQE 2571
Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364
++ ++E +QE L+ E++ EQ LQLL++ Q + + EE A + L
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQ--LQLLEE--QHRAALAHSEEVTASQVAATKTLP 2627
Query: 365 E----MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL----- 415
+ P +E R V+ + L E ++ E+ L Q V EL
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2687
Query: 416 -EHWIAEKEVVAG 427
H++ + +AG
Sbjct: 2688 VRHYLQGRSSIAG 2700
Score = 35.8 bits (81), Expect = 0.13
Identities = 69/272 (25%), Positives = 113/272 (41%), Gaps = 53/272 (19%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82
Q F E+A+ ++ E+ +R+ QQ+ QE+ L AS+ E R+ E E + K +L
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME----EARRRQHEAEEGVRRKQEEL 2573
Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142
QL Q + ++ L +L++ +LQ +E Q
Sbjct: 2574 ------QQLEQQRRQQEELLAEENQRLRE---------------QLQLLEEQHRAALAHS 2612
Query: 143 GELQA-QTAALPLEPASKE-LVGERQNAVGERLVRLLEPLQERRRL----LLASKELHQV 196
E+ A Q AA P ++ L G A E L +RL +L+++EL ++
Sbjct: 2613 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2672
Query: 197 A--HDLDDELA-------WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 247
A H DELA ++Q R +A G L+A + + L+R++ + G L
Sbjct: 2673 AQGHTTVDELARREDVRHYLQGRSSIA-----GLLLKATNEKLSVYAALQRQLLSPGTAL 2727
Query: 248 EEVLERAGALASLRSPEA-------EAVRRGL 272
+LE A L P EAV+ G+
Sbjct: 2728 -ILLEAQAASGFLLDPVRNRRLTVNEAVKEGV 2758
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 70.5 bits (171), Expect = 5e-12
Identities = 140/625 (22%), Positives = 248/625 (39%), Gaps = 59/625 (9%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
EL + E+ E + +Q +E L V+ + RQ EL S +A+A E +
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1537
Query: 88 ADQLVQSFA----ELDKKLLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQV 135
A Q ++ E +++L E + L+ + A + S+ +Q+
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQL 1596
Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELH 194
E +E AQ A ++ ER ER L R E RL L ++E+
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1656
Query: 195 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 254
Q E +E + QAV+Q Q L ++ Q ++ L
Sbjct: 1657 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1716
Query: 255 GALASLRSP--EAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 312
L LR+ + E R+ LE+ + AA +++Q L+A ++A+V A
Sbjct: 1717 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---------ELAKVRA- 1766
Query: 313 LGEQELLMMSEDKGKDE-QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD- 370
E E+L+ S+ + ++E +ST + K+ L+ E G + E +A+ + + RAL E
Sbjct: 1767 --EMEVLLASKARAEEESRSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQR 1821
Query: 371 ---SEQISRRQSQVDRLYVA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426
E +R++++ +R+ L +GE R+ E + L + + L +AE E
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQ 1880
Query: 427 GSPELGQDFEHVSVLQEKF--------SEFASETGMAGRERLAAVNQMVDELIECGHT-- 476
Q +H + ++E+ SE + G+ + L Q+ +E++ +
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFE 1939
Query: 477 -AAATMAEWKDGLNEAWA---------ELLELMGTRAQLLAASRELHKFFSDARELQGQI 526
AAA AE + L + E EL R + LAA E + ++ R +
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999
Query: 527 EEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586
E+ R E + ++ R E Q Q++ QE A + HA
Sbjct: 2000 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2059
Query: 587 EAIASREQEVLQGWKELLSACEDAR 611
A+ +EQE+ Q ++ S + R
Sbjct: 2060 FAVQQKEQELQQTLQQEQSVLDQLR 2084
Score = 64.7 bits (156), Expect = 3e-10
Identities = 131/640 (20%), Positives = 245/640 (38%), Gaps = 106/640 (16%)
Query: 37 EKIEREGQQLMQEK---PELAASVRKK-LGEIRQCWAELESTTQAKARQLFEASKADQLV 92
E+ RE ++ +Q+ E AA RK L E+ + A++E + + R E+++ QL
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043
Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152
Q A+ +LQ + A + + Q+++ + + GE +A A
Sbjct: 2044 QEAAQ---------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Query: 153 PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 212
E + ER+ A R V E L++ ++ Q A E+L
Sbjct: 2095 E-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----------AEKLR 2143
Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS------LRSPEAE 266
+ E QA Q +++ Q E++ H E+ L + + L+ E +
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 267 AVRRGL-EQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
+ L E+LQ A EAA +R QV + F V ++++++A + + ++ DK
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2263
Query: 326 GKDEQSTLQLLKKHLQLEQGVENY--------------EESIAQ---------------- 355
++ + +K Q+ + EE +AQ
Sbjct: 2264 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2323
Query: 356 -----LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE--LGEERRVALEQQYWLYQL 408
L + L + EQ R Q +++ L E G +R + E+Q L ++
Sbjct: 2324 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EM 2382
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468
S + L+ +AE E +D + E+ E T +A +E++ V +
Sbjct: 2383 SAEAERLKLRVAEMSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 469 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 528
+ + H A + L EA AEL RE K +A+ LQ + EE
Sbjct: 2441 QRQQSDHDA--------ERLREAIAEL-------------EREKEKLQQEAKLLQLKSEE 2479
Query: 529 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 588
+ + Q ++F + L+ + R +++ A+L ++ E A+A
Sbjct: 2480 MQ--------TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531
Query: 589 IASRE------QEVLQGWKELLSACEDARLHVSSTADALR 622
RE Q++ Q + L+++ E+AR + +R
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571
Score = 63.9 bits (154), Expect = 5e-10
Identities = 134/617 (21%), Positives = 247/617 (40%), Gaps = 51/617 (8%)
Query: 9 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 68
+E + +R Q AE+ + + ++ E ++++ PE + + E+
Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTL 1075
Query: 69 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 128
+LE A L + +++ ++ L E QL++ V + L +L
Sbjct: 1076 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ------AVPATLPEL 1129
Query: 129 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGER-QNAVGERLVRL------LEPLQ 181
++ ++ +++ + Q AL E + VGER Q GER V + + L
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1189
Query: 182 ERRRLLLAS-----KELHQVAHDL-------DDELAWVQE--RLPLAMQTERGNGLQAVQ 227
ER + +LA +EL Q+ L D AW+Q+ R +Q QAV+
Sbjct: 1190 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1249
Query: 228 QHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLRE 284
+ +++ Q L EI+ HG ++EE A + +++ E + V + LE + S A +
Sbjct: 1250 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPK 1308
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341
+ V+ + +Y ++ + + + L M E++ EQ + ++ +
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1368
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401
+E +E + +A+ Q +A E + +Q R Q +V R A + +++R E+
Sbjct: 1369 VEAALEK-QRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE 1425
Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLA 461
L QL RQ SE E ++ A + E + V++ + + G A E L
Sbjct: 1426 ---LQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQ 1480
Query: 462 AVNQMVDEL----IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517
A+ +E + A + +D +EL A+RE +
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577
EL+ Q EE RRL R R +++ R+ E +LQ S+ E AQL
Sbjct: 1541 ALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAELQ---SKRASFAEKTAQL 1596
Query: 578 RTVYAGEHAEAIASREQ 594
EH RE+
Sbjct: 1597 ERSLQEEHVAVAQLREE 1613
Score = 61.6 bits (148), Expect = 2e-09
Identities = 160/718 (22%), Positives = 285/718 (39%), Gaps = 134/718 (18%)
Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLE----KIEREGQQLMQEKPELAASVRKKL 61
+GT + + +R +A + Q ++ LE +++RE Q++ EL A
Sbjct: 1706 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA------ 1759
Query: 62 GEIRQCWAELESTTQAKARQLFE----ASKADQLVQS----FAELDKKLLHMESQLQDVD 113
E+ + AE+E +KAR E + K+ Q +++ F EL ++ + + ++
Sbjct: 1760 -ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERL 173
LA ++ ++ ++ E + E +GE A E A KE + A ERL
Sbjct: 1819 RQRQLAEEDAARQRAEA-ERVLAEKLAAIGE--ATRLKTEAEIALKE-----KEAENERL 1870
Query: 174 VRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKN 233
RL E +RR L H+ D+++ LA Q R + ER GL V+ +++
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKA--DIEERLA--QLRKASDSELERQKGL--VEDTLRQR 1924
Query: 234 QGLRREI--------QAHGPRLEEVLE----RAGALASLRSPE-------------AEAV 268
+ + EI +A + E LE R+ A +LRS E AE
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984
Query: 269 RR---GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
RR E++Q + A EAA +R+ L+ +VE+ V E E ++
Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALE---EVERLKAKVEEARRLRERAE-----QES 2036
Query: 326 GKDEQSTLQLLKKHLQLEQ-----GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380
+ Q + +K LQ E+ V+ E+ + Q +Q +++L+ ++E R +
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096
Query: 381 VDRLYV-----------------ALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423
+ V LK+ EE+ A Q + R+ +E E A +
Sbjct: 2097 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---AARR 2153
Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH-------- 475
A L Q + EK +FA +T + + + +L E H
Sbjct: 2154 AQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212
Query: 476 ---------TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL--------HKFFSD 518
AA ++ ++ L ++ EL +A++ A +R L +F +
Sbjct: 2213 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2272
Query: 519 ARELQGQIEEKRRRL-------PRLTTPPE-----PRPSASSM-QRTLRAFEHDLQLLV- 564
E Q+ E+ RL RL E R A M + ++A + +L
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2332
Query: 565 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622
+++ Q Q+ AQ + E E +A + E QG++ L A +L +S+ A+ L+
Sbjct: 2333 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390
Score = 58.9 bits (141), Expect = 1e-08
Identities = 130/625 (20%), Positives = 238/625 (38%), Gaps = 123/625 (19%)
Query: 18 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 76
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 297 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 355
Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 356 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 403
Query: 137 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ E G + E+L + LQ RLL A K + Q
Sbjct: 404 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 438
Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 254
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 439 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 484
Query: 255 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 485 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 536
Query: 314 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 537 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 585
Query: 374 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 586 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 640
Query: 426 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 641 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 697
Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 698 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 749
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 598
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 750 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 800
Query: 599 --------GWKELLSACEDARLHVS 615
G LL+ C+ ++ V+
Sbjct: 801 RHPAHPMRGRLPLLAVCDYKQVEVT 825
Score = 52.4 bits (124), Expect = 1e-06
Identities = 107/433 (24%), Positives = 179/433 (41%), Gaps = 65/433 (15%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
+LAQ + EK+ +E Q +QE L A E+ Q EL Q +AR+L E
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAE-----AELLQQQKEL---AQEQARRLQE--D 2353
Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147
+Q+ Q AE E+Q G T+ ++ ++ M ++ E V E+ +
Sbjct: 2354 KEQMAQQLAE--------ETQ-------GFQRTLEAERQRQLEMSAEAERLKLRVAEM-S 2397
Query: 148 QTAALPLEPASK-----ELVGE---RQNAVGERLVRLLEPLQERR--------RLLLASK 191
+ A E A + E +GE R + V L++ L+ +R RL A
Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2457
Query: 192 ELHQVAHDLDDELAWVQ---ERLPLAMQTERGNGLQAVQQHI--KKNQGLRRE--IQAHG 244
EL + L E +Q E + Q + QA+QQ +K+ L+RE I+
Sbjct: 2458 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2517
Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304
+LE++ + A A E + ++ +EQ + E A RRQ +A V +
Sbjct: 2518 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH--EAEEGVRRKQE 2575
Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364
++ ++E +QE L+ E++ EQ LQLL++ Q + + EE A + L
Sbjct: 2576 ELQQLEQQRRQQEELLAEENQRLREQ--LQLLEE--QHRAALAHSEEVTASQVAATKTLP 2631
Query: 365 E----MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL----- 415
+ P +E R V+ + L E ++ E+ L Q V EL
Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2691
Query: 416 -EHWIAEKEVVAG 427
H++ + +AG
Sbjct: 2692 VRHYLQGRSSIAG 2704
Score = 35.8 bits (81), Expect = 0.13
Identities = 69/272 (25%), Positives = 113/272 (41%), Gaps = 53/272 (19%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82
Q F E+A+ ++ E+ +R+ QQ+ QE+ L AS+ E R+ E E + K +L
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME----EARRRQHEAEEGVRRKQEEL 2577
Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142
QL Q + ++ L +L++ +LQ +E Q
Sbjct: 2578 ------QQLEQQRRQQEELLAEENQRLRE---------------QLQLLEEQHRAALAHS 2616
Query: 143 GELQA-QTAALPLEPASKE-LVGERQNAVGERLVRLLEPLQERRRL----LLASKELHQV 196
E+ A Q AA P ++ L G A E L +RL +L+++EL ++
Sbjct: 2617 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2676
Query: 197 A--HDLDDELA-------WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 247
A H DELA ++Q R +A G L+A + + L+R++ + G L
Sbjct: 2677 AQGHTTVDELARREDVRHYLQGRSSIA-----GLLLKATNEKLSVYAALQRQLLSPGTAL 2731
Query: 248 EEVLERAGALASLRSPEA-------EAVRRGL 272
+LE A L P EAV+ G+
Sbjct: 2732 -ILLEAQAASGFLLDPVRNRRLTVNEAVKEGV 2762
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 70.5 bits (171), Expect = 5e-12
Identities = 140/625 (22%), Positives = 248/625 (39%), Gaps = 59/625 (9%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
EL + E+ E + +Q +E L V+ + RQ EL S +A+A E +
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 88 ADQLVQSFA----ELDKKLLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQV 135
A Q ++ E +++L E + L+ + A + S+ +Q+
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQL 1592
Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELH 194
E +E AQ A ++ ER ER L R E RL L ++E+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652
Query: 195 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 254
Q E +E + QAV+Q Q L ++ Q ++ L
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712
Query: 255 GALASLRSP--EAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 312
L LR+ + E R+ LE+ + AA +++Q L+A ++A+V A
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---------ELAKVRA- 1762
Query: 313 LGEQELLMMSEDKGKDE-QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD- 370
E E+L+ S+ + ++E +ST + K+ L+ E G + E +A+ + + RAL E
Sbjct: 1763 --EMEVLLASKARAEEESRSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQR 1817
Query: 371 ---SEQISRRQSQVDRLYVA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426
E +R++++ +R+ L +GE R+ E + L + + L +AE E
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQ 1876
Query: 427 GSPELGQDFEHVSVLQEKF--------SEFASETGMAGRERLAAVNQMVDELIECGHT-- 476
Q +H + ++E+ SE + G+ + L Q+ +E++ +
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFE 1935
Query: 477 -AAATMAEWKDGLNEAWA---------ELLELMGTRAQLLAASRELHKFFSDARELQGQI 526
AAA AE + L + E EL R + LAA E + ++ R +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 527 EEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586
E+ R E + ++ R E Q Q++ QE A + HA
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055
Query: 587 EAIASREQEVLQGWKELLSACEDAR 611
A+ +EQE+ Q ++ S + R
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLR 2080
Score = 64.7 bits (156), Expect = 3e-10
Identities = 131/640 (20%), Positives = 245/640 (38%), Gaps = 106/640 (16%)
Query: 37 EKIEREGQQLMQEK---PELAASVRKK-LGEIRQCWAELESTTQAKARQLFEASKADQLV 92
E+ RE ++ +Q+ E AA RK L E+ + A++E + + R E+++ QL
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152
Q A+ +LQ + A + + Q+++ + + GE +A A
Sbjct: 2040 QEAAQ---------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 153 PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 212
E + ER+ A R V E L++ ++ Q A E+L
Sbjct: 2091 E-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----------AEKLR 2139
Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS------LRSPEAE 266
+ E QA Q +++ Q E++ H E+ L + + L+ E +
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 267 AVRRGL-EQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
+ L E+LQ A EAA +R QV + F V ++++++A + + ++ DK
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259
Query: 326 GKDEQSTLQLLKKHLQLEQGVENY--------------EESIAQ---------------- 355
++ + +K Q+ + EE +AQ
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2319
Query: 356 -----LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE--LGEERRVALEQQYWLYQL 408
L + L + EQ R Q +++ L E G +R + E+Q L ++
Sbjct: 2320 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EM 2378
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468
S + L+ +AE E +D + E+ E T +A +E++ V +
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 469 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 528
+ + H A + L EA AEL RE K +A+ LQ + EE
Sbjct: 2437 QRQQSDHDA--------ERLREAIAEL-------------EREKEKLQQEAKLLQLKSEE 2475
Query: 529 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 588
+ + Q ++F + L+ + R +++ A+L ++ E A+A
Sbjct: 2476 MQ--------TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 589 IASRE------QEVLQGWKELLSACEDARLHVSSTADALR 622
RE Q++ Q + L+++ E+AR + +R
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Score = 63.9 bits (154), Expect = 5e-10
Identities = 134/617 (21%), Positives = 247/617 (40%), Gaps = 51/617 (8%)
Query: 9 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 68
+E + +R Q AE+ + + ++ E ++++ PE + + E+
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTL 1071
Query: 69 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 128
+LE A L + +++ ++ L E QL++ V + L +L
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ------AVPATLPEL 1125
Query: 129 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGER-QNAVGERLVRL------LEPLQ 181
++ ++ +++ + Q AL E + VGER Q GER V + + L
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185
Query: 182 ERRRLLLAS-----KELHQVAHDL-------DDELAWVQE--RLPLAMQTERGNGLQAVQ 227
ER + +LA +EL Q+ L D AW+Q+ R +Q QAV+
Sbjct: 1186 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1245
Query: 228 QHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLRE 284
+ +++ Q L EI+ HG ++EE A + +++ E + V + LE + S A +
Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPK 1304
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341
+ V+ + +Y ++ + + + L M E++ EQ + ++ +
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401
+E +E + +A+ Q +A E + +Q R Q +V R A + +++R E+
Sbjct: 1365 VEAALEK-QRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE 1421
Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLA 461
L QL RQ SE E ++ A + E + V++ + + G A E L
Sbjct: 1422 ---LQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQ 1476
Query: 462 AVNQMVDEL----IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517
A+ +E + A + +D +EL A+RE +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577
EL+ Q EE RRL R R +++ R+ E +LQ S+ E AQL
Sbjct: 1537 ALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAELQ---SKRASFAEKTAQL 1592
Query: 578 RTVYAGEHAEAIASREQ 594
EH RE+
Sbjct: 1593 ERSLQEEHVAVAQLREE 1609
Score = 61.6 bits (148), Expect = 2e-09
Identities = 160/718 (22%), Positives = 285/718 (39%), Gaps = 134/718 (18%)
Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLE----KIEREGQQLMQEKPELAASVRKKL 61
+GT + + +R +A + Q ++ LE +++RE Q++ EL A
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA------ 1755
Query: 62 GEIRQCWAELESTTQAKARQLFE----ASKADQLVQS----FAELDKKLLHMESQLQDVD 113
E+ + AE+E +KAR E + K+ Q +++ F EL ++ + + ++
Sbjct: 1756 -ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERL 173
LA ++ ++ ++ E + E +GE A E A KE + A ERL
Sbjct: 1815 RQRQLAEEDAARQRAEA-ERVLAEKLAAIGE--ATRLKTEAEIALKE-----KEAENERL 1866
Query: 174 VRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKN 233
RL E +RR L H+ D+++ LA Q R + ER GL V+ +++
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKA--DIEERLA--QLRKASDSELERQKGL--VEDTLRQR 1920
Query: 234 QGLRREI--------QAHGPRLEEVLE----RAGALASLRSPE-------------AEAV 268
+ + EI +A + E LE R+ A +LRS E AE
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 269 RR---GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
RR E++Q + A EAA +R+ L+ +VE+ V E E ++
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALE---EVERLKAKVEEARRLRERAE-----QES 2032
Query: 326 GKDEQSTLQLLKKHLQLEQ-----GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380
+ Q + +K LQ E+ V+ E+ + Q +Q +++L+ ++E R +
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 381 VDRLYV-----------------ALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423
+ V LK+ EE+ A Q + R+ +E E A +
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---AARR 2149
Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH-------- 475
A L Q + EK +FA +T + + + +L E H
Sbjct: 2150 AQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 476 ---------TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL--------HKFFSD 518
AA ++ ++ L ++ EL +A++ A +R L +F +
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268
Query: 519 ARELQGQIEEKRRRL-------PRLTTPPE-----PRPSASSM-QRTLRAFEHDLQLLV- 564
E Q+ E+ RL RL E R A M + ++A + +L
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2328
Query: 565 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622
+++ Q Q+ AQ + E E +A + E QG++ L A +L +S+ A+ L+
Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Score = 58.9 bits (141), Expect = 1e-08
Identities = 130/625 (20%), Positives = 238/625 (38%), Gaps = 123/625 (19%)
Query: 18 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 76
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 293 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 351
Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 352 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 399
Query: 137 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ E G + E+L + LQ RLL A K + Q
Sbjct: 400 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 434
Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 254
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 435 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 480
Query: 255 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 481 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 532
Query: 314 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 581
Query: 374 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 582 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 636
Query: 426 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 637 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 693
Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 694 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 745
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 598
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 746 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 796
Query: 599 --------GWKELLSACEDARLHVS 615
G LL+ C+ ++ V+
Sbjct: 797 RHPAHPMRGRLPLLAVCDYKQVEVT 821
Score = 52.4 bits (124), Expect = 1e-06
Identities = 107/433 (24%), Positives = 179/433 (41%), Gaps = 65/433 (15%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
+LAQ + EK+ +E Q +QE L A E+ Q EL Q +AR+L E
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAE-----AELLQQQKEL---AQEQARRLQE--D 2349
Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147
+Q+ Q AE E+Q G T+ ++ ++ M ++ E V E+ +
Sbjct: 2350 KEQMAQQLAE--------ETQ-------GFQRTLEAERQRQLEMSAEAERLKLRVAEM-S 2393
Query: 148 QTAALPLEPASK-----ELVGE---RQNAVGERLVRLLEPLQERR--------RLLLASK 191
+ A E A + E +GE R + V L++ L+ +R RL A
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453
Query: 192 ELHQVAHDLDDELAWVQ---ERLPLAMQTERGNGLQAVQQHI--KKNQGLRRE--IQAHG 244
EL + L E +Q E + Q + QA+QQ +K+ L+RE I+
Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304
+LE++ + A A E + ++ +EQ + E A RRQ +A V +
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH--EAEEGVRRKQE 2571
Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364
++ ++E +QE L+ E++ EQ LQLL++ Q + + EE A + L
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQ--LQLLEE--QHRAALAHSEEVTASQVAATKTLP 2627
Query: 365 E----MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL----- 415
+ P +E R V+ + L E ++ E+ L Q V EL
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2687
Query: 416 -EHWIAEKEVVAG 427
H++ + +AG
Sbjct: 2688 VRHYLQGRSSIAG 2700
Score = 35.8 bits (81), Expect = 0.13
Identities = 69/272 (25%), Positives = 113/272 (41%), Gaps = 53/272 (19%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82
Q F E+A+ ++ E+ +R+ QQ+ QE+ L AS+ E R+ E E + K +L
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME----EARRRQHEAEEGVRRKQEEL 2573
Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142
QL Q + ++ L +L++ +LQ +E Q
Sbjct: 2574 ------QQLEQQRRQQEELLAEENQRLRE---------------QLQLLEEQHRAALAHS 2612
Query: 143 GELQA-QTAALPLEPASKE-LVGERQNAVGERLVRLLEPLQERRRL----LLASKELHQV 196
E+ A Q AA P ++ L G A E L +RL +L+++EL ++
Sbjct: 2613 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2672
Query: 197 A--HDLDDELA-------WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 247
A H DELA ++Q R +A G L+A + + L+R++ + G L
Sbjct: 2673 AQGHTTVDELARREDVRHYLQGRSSIA-----GLLLKATNEKLSVYAALQRQLLSPGTAL 2727
Query: 248 EEVLERAGALASLRSPEA-------EAVRRGL 272
+LE A L P EAV+ G+
Sbjct: 2728 -ILLEAQAASGFLLDPVRNRRLTVNEAVKEGV 2758
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 70.5 bits (171), Expect = 5e-12
Identities = 140/625 (22%), Positives = 248/625 (39%), Gaps = 59/625 (9%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
EL + E+ E + +Q +E L V+ + RQ EL S +A+A E +
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1501
Query: 88 ADQLVQSFA----ELDKKLLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQV 135
A Q ++ E +++L E + L+ + A + S+ +Q+
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQL 1560
Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELH 194
E +E AQ A ++ ER ER L R E RL L ++E+
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1620
Query: 195 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 254
Q E +E + QAV+Q Q L ++ Q ++ L
Sbjct: 1621 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1680
Query: 255 GALASLRSP--EAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 312
L LR+ + E R+ LE+ + AA +++Q L+A ++A+V A
Sbjct: 1681 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---------ELAKVRA- 1730
Query: 313 LGEQELLMMSEDKGKDE-QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD- 370
E E+L+ S+ + ++E +ST + K+ L+ E G + E +A+ + + RAL E
Sbjct: 1731 --EMEVLLASKARAEEESRSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQR 1785
Query: 371 ---SEQISRRQSQVDRLYVA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426
E +R++++ +R+ L +GE R+ E + L + + L +AE E
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQ 1844
Query: 427 GSPELGQDFEHVSVLQEKF--------SEFASETGMAGRERLAAVNQMVDELIECGHT-- 476
Q +H + ++E+ SE + G+ + L Q+ +E++ +
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFE 1903
Query: 477 -AAATMAEWKDGLNEAWA---------ELLELMGTRAQLLAASRELHKFFSDARELQGQI 526
AAA AE + L + E EL R + LAA E + ++ R +
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963
Query: 527 EEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586
E+ R E + ++ R E Q Q++ QE A + HA
Sbjct: 1964 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2023
Query: 587 EAIASREQEVLQGWKELLSACEDAR 611
A+ +EQE+ Q ++ S + R
Sbjct: 2024 FAVQQKEQELQQTLQQEQSVLDQLR 2048
Score = 64.7 bits (156), Expect = 3e-10
Identities = 131/640 (20%), Positives = 245/640 (38%), Gaps = 106/640 (16%)
Query: 37 EKIEREGQQLMQEK---PELAASVRKK-LGEIRQCWAELESTTQAKARQLFEASKADQLV 92
E+ RE ++ +Q+ E AA RK L E+ + A++E + + R E+++ QL
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007
Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152
Q A+ +LQ + A + + Q+++ + + GE +A A
Sbjct: 2008 QEAAQ---------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Query: 153 PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 212
E + ER+ A R V E L++ ++ Q A E+L
Sbjct: 2059 E-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----------AEKLR 2107
Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS------LRSPEAE 266
+ E QA Q +++ Q E++ H E+ L + + L+ E +
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 267 AVRRGL-EQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
+ L E+LQ A EAA +R QV + F V ++++++A + + ++ DK
Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2227
Query: 326 GKDEQSTLQLLKKHLQLEQGVENY--------------EESIAQ---------------- 355
++ + +K Q+ + EE +AQ
Sbjct: 2228 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2287
Query: 356 -----LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE--LGEERRVALEQQYWLYQL 408
L + L + EQ R Q +++ L E G +R + E+Q L ++
Sbjct: 2288 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EM 2346
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468
S + L+ +AE E +D + E+ E T +A +E++ V +
Sbjct: 2347 SAEAERLKLRVAEMSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 469 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 528
+ + H A + L EA AEL RE K +A+ LQ + EE
Sbjct: 2405 QRQQSDHDA--------ERLREAIAEL-------------EREKEKLQQEAKLLQLKSEE 2443
Query: 529 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 588
+ + Q ++F + L+ + R +++ A+L ++ E A+A
Sbjct: 2444 MQ--------TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495
Query: 589 IASRE------QEVLQGWKELLSACEDARLHVSSTADALR 622
RE Q++ Q + L+++ E+AR + +R
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535
Score = 63.9 bits (154), Expect = 5e-10
Identities = 134/617 (21%), Positives = 247/617 (40%), Gaps = 51/617 (8%)
Query: 9 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 68
+E + +R Q AE+ + + ++ E ++++ PE + + E+
Sbjct: 981 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTL 1039
Query: 69 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 128
+LE A L + +++ ++ L E QL++ V + L +L
Sbjct: 1040 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ------AVPATLPEL 1093
Query: 129 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGER-QNAVGERLVRL------LEPLQ 181
++ ++ +++ + Q AL E + VGER Q GER V + + L
Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1153
Query: 182 ERRRLLLAS-----KELHQVAHDL-------DDELAWVQE--RLPLAMQTERGNGLQAVQ 227
ER + +LA +EL Q+ L D AW+Q+ R +Q QAV+
Sbjct: 1154 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1213
Query: 228 QHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLRE 284
+ +++ Q L EI+ HG ++EE A + +++ E + V + LE + S A +
Sbjct: 1214 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPK 1272
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341
+ V+ + +Y ++ + + + L M E++ EQ + ++ +
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1332
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401
+E +E + +A+ Q +A E + +Q R Q +V R A + +++R E+
Sbjct: 1333 VEAALEK-QRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE 1389
Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLA 461
L QL RQ SE E ++ A + E + V++ + + G A E L
Sbjct: 1390 ---LQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQ 1444
Query: 462 AVNQMVDEL----IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517
A+ +E + A + +D +EL A+RE +
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577
EL+ Q EE RRL R R +++ R+ E +LQ S+ E AQL
Sbjct: 1505 ALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAELQ---SKRASFAEKTAQL 1560
Query: 578 RTVYAGEHAEAIASREQ 594
EH RE+
Sbjct: 1561 ERSLQEEHVAVAQLREE 1577
Score = 61.6 bits (148), Expect = 2e-09
Identities = 160/718 (22%), Positives = 285/718 (39%), Gaps = 134/718 (18%)
Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLE----KIEREGQQLMQEKPELAASVRKKL 61
+GT + + +R +A + Q ++ LE +++RE Q++ EL A
Sbjct: 1670 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA------ 1723
Query: 62 GEIRQCWAELESTTQAKARQLFE----ASKADQLVQS----FAELDKKLLHMESQLQDVD 113
E+ + AE+E +KAR E + K+ Q +++ F EL ++ + + ++
Sbjct: 1724 -ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERL 173
LA ++ ++ ++ E + E +GE A E A KE + A ERL
Sbjct: 1783 RQRQLAEEDAARQRAEA-ERVLAEKLAAIGE--ATRLKTEAEIALKE-----KEAENERL 1834
Query: 174 VRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKN 233
RL E +RR L H+ D+++ LA Q R + ER GL V+ +++
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKA--DIEERLA--QLRKASDSELERQKGL--VEDTLRQR 1888
Query: 234 QGLRREI--------QAHGPRLEEVLE----RAGALASLRSPE-------------AEAV 268
+ + EI +A + E LE R+ A +LRS E AE
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948
Query: 269 RR---GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
RR E++Q + A EAA +R+ L+ +VE+ V E E ++
Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALE---EVERLKAKVEEARRLRERAE-----QES 2000
Query: 326 GKDEQSTLQLLKKHLQLEQ-----GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380
+ Q + +K LQ E+ V+ E+ + Q +Q +++L+ ++E R +
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060
Query: 381 VDRLYV-----------------ALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423
+ V LK+ EE+ A Q + R+ +E E A +
Sbjct: 2061 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---AARR 2117
Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH-------- 475
A L Q + EK +FA +T + + + +L E H
Sbjct: 2118 AQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176
Query: 476 ---------TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL--------HKFFSD 518
AA ++ ++ L ++ EL +A++ A +R L +F +
Sbjct: 2177 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2236
Query: 519 ARELQGQIEEKRRRL-------PRLTTPPE-----PRPSASSM-QRTLRAFEHDLQLLV- 564
E Q+ E+ RL RL E R A M + ++A + +L
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2296
Query: 565 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622
+++ Q Q+ AQ + E E +A + E QG++ L A +L +S+ A+ L+
Sbjct: 2297 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354
Score = 58.9 bits (141), Expect = 1e-08
Identities = 130/625 (20%), Positives = 238/625 (38%), Gaps = 123/625 (19%)
Query: 18 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 76
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 261 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 319
Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 320 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 367
Query: 137 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ E G + E+L + LQ RLL A K + Q
Sbjct: 368 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 402
Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 254
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 403 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 448
Query: 255 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 449 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 500
Query: 314 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 501 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 549
Query: 374 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 550 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 604
Query: 426 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 605 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 661
Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 662 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 713
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 598
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 714 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 764
Query: 599 --------GWKELLSACEDARLHVS 615
G LL+ C+ ++ V+
Sbjct: 765 RHPAHPMRGRLPLLAVCDYKQVEVT 789
Score = 52.4 bits (124), Expect = 1e-06
Identities = 107/433 (24%), Positives = 179/433 (41%), Gaps = 65/433 (15%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
+LAQ + EK+ +E Q +QE L A E+ Q EL Q +AR+L E
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAE-----AELLQQQKEL---AQEQARRLQE--D 2317
Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147
+Q+ Q AE E+Q G T+ ++ ++ M ++ E V E+ +
Sbjct: 2318 KEQMAQQLAE--------ETQ-------GFQRTLEAERQRQLEMSAEAERLKLRVAEM-S 2361
Query: 148 QTAALPLEPASK-----ELVGE---RQNAVGERLVRLLEPLQERR--------RLLLASK 191
+ A E A + E +GE R + V L++ L+ +R RL A
Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2421
Query: 192 ELHQVAHDLDDELAWVQ---ERLPLAMQTERGNGLQAVQQHI--KKNQGLRRE--IQAHG 244
EL + L E +Q E + Q + QA+QQ +K+ L+RE I+
Sbjct: 2422 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2481
Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304
+LE++ + A A E + ++ +EQ + E A RRQ +A V +
Sbjct: 2482 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH--EAEEGVRRKQE 2539
Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364
++ ++E +QE L+ E++ EQ LQLL++ Q + + EE A + L
Sbjct: 2540 ELQQLEQQRRQQEELLAEENQRLREQ--LQLLEE--QHRAALAHSEEVTASQVAATKTLP 2595
Query: 365 E----MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL----- 415
+ P +E R V+ + L E ++ E+ L Q V EL
Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2655
Query: 416 -EHWIAEKEVVAG 427
H++ + +AG
Sbjct: 2656 VRHYLQGRSSIAG 2668
Score = 35.8 bits (81), Expect = 0.13
Identities = 69/272 (25%), Positives = 113/272 (41%), Gaps = 53/272 (19%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82
Q F E+A+ ++ E+ +R+ QQ+ QE+ L AS+ E R+ E E + K +L
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME----EARRRQHEAEEGVRRKQEEL 2541
Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142
QL Q + ++ L +L++ +LQ +E Q
Sbjct: 2542 ------QQLEQQRRQQEELLAEENQRLRE---------------QLQLLEEQHRAALAHS 2580
Query: 143 GELQA-QTAALPLEPASKE-LVGERQNAVGERLVRLLEPLQERRRL----LLASKELHQV 196
E+ A Q AA P ++ L G A E L +RL +L+++EL ++
Sbjct: 2581 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2640
Query: 197 A--HDLDDELA-------WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 247
A H DELA ++Q R +A G L+A + + L+R++ + G L
Sbjct: 2641 AQGHTTVDELARREDVRHYLQGRSSIA-----GLLLKATNEKLSVYAALQRQLLSPGTAL 2695
Query: 248 EEVLERAGALASLRSPEA-------EAVRRGL 272
+LE A L P EAV+ G+
Sbjct: 2696 -ILLEAQAASGFLLDPVRNRRLTVNEAVKEGV 2726
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 70.5 bits (171), Expect = 5e-12
Identities = 140/625 (22%), Positives = 248/625 (39%), Gaps = 59/625 (9%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
EL + E+ E + +Q +E L V+ + RQ EL S +A+A E +
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1670
Query: 88 ADQLVQSFA----ELDKKLLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQV 135
A Q ++ E +++L E + L+ + A + S+ +Q+
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQL 1729
Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELH 194
E +E AQ A ++ ER ER L R E RL L ++E+
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1789
Query: 195 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 254
Q E +E + QAV+Q Q L ++ Q ++ L
Sbjct: 1790 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1849
Query: 255 GALASLRSP--EAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 312
L LR+ + E R+ LE+ + AA +++Q L+A ++A+V A
Sbjct: 1850 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---------ELAKVRA- 1899
Query: 313 LGEQELLMMSEDKGKDE-QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD- 370
E E+L+ S+ + ++E +ST + K+ L+ E G + E +A+ + + RAL E
Sbjct: 1900 --EMEVLLASKARAEEESRSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQR 1954
Query: 371 ---SEQISRRQSQVDRLYVA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426
E +R++++ +R+ L +GE R+ E + L + + L +AE E
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQ 2013
Query: 427 GSPELGQDFEHVSVLQEKF--------SEFASETGMAGRERLAAVNQMVDELIECGHT-- 476
Q +H + ++E+ SE + G+ + L Q+ +E++ +
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFE 2072
Query: 477 -AAATMAEWKDGLNEAWA---------ELLELMGTRAQLLAASRELHKFFSDARELQGQI 526
AAA AE + L + E EL R + LAA E + ++ R +
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132
Query: 527 EEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586
E+ R E + ++ R E Q Q++ QE A + HA
Sbjct: 2133 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2192
Query: 587 EAIASREQEVLQGWKELLSACEDAR 611
A+ +EQE+ Q ++ S + R
Sbjct: 2193 FAVQQKEQELQQTLQQEQSVLDQLR 2217
Score = 64.7 bits (156), Expect = 3e-10
Identities = 131/640 (20%), Positives = 245/640 (38%), Gaps = 106/640 (16%)
Query: 37 EKIEREGQQLMQEK---PELAASVRKK-LGEIRQCWAELESTTQAKARQLFEASKADQLV 92
E+ RE ++ +Q+ E AA RK L E+ + A++E + + R E+++ QL
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176
Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152
Q A+ +LQ + A + + Q+++ + + GE +A A
Sbjct: 2177 QEAAQ---------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Query: 153 PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 212
E + ER+ A R V E L++ ++ Q A E+L
Sbjct: 2228 E-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----------AEKLR 2276
Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS------LRSPEAE 266
+ E QA Q +++ Q E++ H E+ L + + L+ E +
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 267 AVRRGL-EQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
+ L E+LQ A EAA +R QV + F V ++++++A + + ++ DK
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2396
Query: 326 GKDEQSTLQLLKKHLQLEQGVENY--------------EESIAQ---------------- 355
++ + +K Q+ + EE +AQ
Sbjct: 2397 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2456
Query: 356 -----LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE--LGEERRVALEQQYWLYQL 408
L + L + EQ R Q +++ L E G +R + E+Q L ++
Sbjct: 2457 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EM 2515
Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468
S + L+ +AE E +D + E+ E T +A +E++ V +
Sbjct: 2516 SAEAERLKLRVAEMSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 469 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 528
+ + H A + L EA AEL RE K +A+ LQ + EE
Sbjct: 2574 QRQQSDHDA--------ERLREAIAEL-------------EREKEKLQQEAKLLQLKSEE 2612
Query: 529 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 588
+ + Q ++F + L+ + R +++ A+L ++ E A+A
Sbjct: 2613 MQ--------TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664
Query: 589 IASRE------QEVLQGWKELLSACEDARLHVSSTADALR 622
RE Q++ Q + L+++ E+AR + +R
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704
Score = 63.9 bits (154), Expect = 5e-10
Identities = 134/617 (21%), Positives = 247/617 (40%), Gaps = 51/617 (8%)
Query: 9 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 68
+E + +R Q AE+ + + ++ E ++++ PE + + E+
Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTL 1208
Query: 69 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 128
+LE A L + +++ ++ L E QL++ V + L +L
Sbjct: 1209 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ------AVPATLPEL 1262
Query: 129 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGER-QNAVGERLVRL------LEPLQ 181
++ ++ +++ + Q AL E + VGER Q GER V + + L
Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322
Query: 182 ERRRLLLAS-----KELHQVAHDL-------DDELAWVQE--RLPLAMQTERGNGLQAVQ 227
ER + +LA +EL Q+ L D AW+Q+ R +Q QAV+
Sbjct: 1323 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1382
Query: 228 QHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLRE 284
+ +++ Q L EI+ HG ++EE A + +++ E + V + LE + S A +
Sbjct: 1383 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPK 1441
Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341
+ V+ + +Y ++ + + + L M E++ EQ + ++ +
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1501
Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401
+E +E + +A+ Q +A E + +Q R Q +V R A + +++R E+
Sbjct: 1502 VEAALEK-QRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE 1558
Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLA 461
L QL RQ SE E ++ A + E + V++ + + G A E L
Sbjct: 1559 ---LQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQ 1613
Query: 462 AVNQMVDEL----IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517
A+ +E + A + +D +EL A+RE +
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577
EL+ Q EE RRL R R +++ R+ E +LQ S+ E AQL
Sbjct: 1674 ALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAELQ---SKRASFAEKTAQL 1729
Query: 578 RTVYAGEHAEAIASREQ 594
EH RE+
Sbjct: 1730 ERSLQEEHVAVAQLREE 1746
Score = 61.6 bits (148), Expect = 2e-09
Identities = 160/718 (22%), Positives = 285/718 (39%), Gaps = 134/718 (18%)
Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLE----KIEREGQQLMQEKPELAASVRKKL 61
+GT + + +R +A + Q ++ LE +++RE Q++ EL A
Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA------ 1892
Query: 62 GEIRQCWAELESTTQAKARQLFE----ASKADQLVQS----FAELDKKLLHMESQLQDVD 113
E+ + AE+E +KAR E + K+ Q +++ F EL ++ + + ++
Sbjct: 1893 -ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERL 173
LA ++ ++ ++ E + E +GE A E A KE + A ERL
Sbjct: 1952 RQRQLAEEDAARQRAEA-ERVLAEKLAAIGE--ATRLKTEAEIALKE-----KEAENERL 2003
Query: 174 VRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKN 233
RL E +RR L H+ D+++ LA Q R + ER GL V+ +++
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKA--DIEERLA--QLRKASDSELERQKGL--VEDTLRQR 2057
Query: 234 QGLRREI--------QAHGPRLEEVLE----RAGALASLRSPE-------------AEAV 268
+ + EI +A + E LE R+ A +LRS E AE
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117
Query: 269 RR---GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325
RR E++Q + A EAA +R+ L+ +VE+ V E E ++
Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALE---EVERLKAKVEEARRLRERAE-----QES 2169
Query: 326 GKDEQSTLQLLKKHLQLEQ-----GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380
+ Q + +K LQ E+ V+ E+ + Q +Q +++L+ ++E R +
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229
Query: 381 VDRLYV-----------------ALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423
+ V LK+ EE+ A Q + R+ +E E A +
Sbjct: 2230 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---AARR 2286
Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH-------- 475
A L Q + EK +FA +T + + + +L E H
Sbjct: 2287 AQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345
Query: 476 ---------TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL--------HKFFSD 518
AA ++ ++ L ++ EL +A++ A +R L +F +
Sbjct: 2346 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2405
Query: 519 ARELQGQIEEKRRRL-------PRLTTPPE-----PRPSASSM-QRTLRAFEHDLQLLV- 564
E Q+ E+ RL RL E R A M + ++A + +L
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2465
Query: 565 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622
+++ Q Q+ AQ + E E +A + E QG++ L A +L +S+ A+ L+
Sbjct: 2466 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523
Score = 58.9 bits (141), Expect = 1e-08
Identities = 130/625 (20%), Positives = 238/625 (38%), Gaps = 123/625 (19%)
Query: 18 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 76
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 430 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 488
Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 489 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 536
Query: 137 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
+ E G + E+L + LQ RLL A K + Q
Sbjct: 537 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 571
Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 254
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 572 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 617
Query: 255 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 618 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 669
Query: 314 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 670 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 718
Query: 374 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 719 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 773
Query: 426 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 774 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 830
Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 831 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 882
Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 598
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 883 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 933
Query: 599 --------GWKELLSACEDARLHVS 615
G LL+ C+ ++ V+
Sbjct: 934 RHPAHPMRGRLPLLAVCDYKQVEVT 958
Score = 52.4 bits (124), Expect = 1e-06
Identities = 107/433 (24%), Positives = 179/433 (41%), Gaps = 65/433 (15%)
Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87
+LAQ + EK+ +E Q +QE L A E+ Q EL Q +AR+L E
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAE-----AELLQQQKEL---AQEQARRLQE--D 2486
Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147
+Q+ Q AE E+Q G T+ ++ ++ M ++ E V E+ +
Sbjct: 2487 KEQMAQQLAE--------ETQ-------GFQRTLEAERQRQLEMSAEAERLKLRVAEM-S 2530
Query: 148 QTAALPLEPASK-----ELVGE---RQNAVGERLVRLLEPLQERR--------RLLLASK 191
+ A E A + E +GE R + V L++ L+ +R RL A
Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2590
Query: 192 ELHQVAHDLDDELAWVQ---ERLPLAMQTERGNGLQAVQQHI--KKNQGLRRE--IQAHG 244
EL + L E +Q E + Q + QA+QQ +K+ L+RE I+
Sbjct: 2591 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2650
Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304
+LE++ + A A E + ++ +EQ + E A RRQ +A V +
Sbjct: 2651 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH--EAEEGVRRKQE 2708
Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364
++ ++E +QE L+ E++ EQ LQLL++ Q + + EE A + L
Sbjct: 2709 ELQQLEQQRRQQEELLAEENQRLREQ--LQLLEE--QHRAALAHSEEVTASQVAATKTLP 2764
Query: 365 E----MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL----- 415
+ P +E R V+ + L E ++ E+ L Q V EL
Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2824
Query: 416 -EHWIAEKEVVAG 427
H++ + +AG
Sbjct: 2825 VRHYLQGRSSIAG 2837
Score = 35.8 bits (81), Expect = 0.13
Identities = 69/272 (25%), Positives = 113/272 (41%), Gaps = 53/272 (19%)
Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82
Q F E+A+ ++ E+ +R+ QQ+ QE+ L AS+ E R+ E E + K +L
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME----EARRRQHEAEEGVRRKQEEL 2710
Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142
QL Q + ++ L +L++ +LQ +E Q
Sbjct: 2711 ------QQLEQQRRQQEELLAEENQRLRE---------------QLQLLEEQHRAALAHS 2749
Query: 143 GELQA-QTAALPLEPASKE-LVGERQNAVGERLVRLLEPLQERRRL----LLASKELHQV 196
E+ A Q AA P ++ L G A E L +RL +L+++EL ++
Sbjct: 2750 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2809
Query: 197 A--HDLDDELA-------WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 247
A H DELA ++Q R +A G L+A + + L+R++ + G L
Sbjct: 2810 AQGHTTVDELARREDVRHYLQGRSSIA-----GLLLKATNEKLSVYAALQRQLLSPGTAL 2864
Query: 248 EEVLERAGALASLRSPEA-------EAVRRGL 272
+LE A L P EAV+ G+
Sbjct: 2865 -ILLEAQAASGFLLDPVRNRRLTVNEAVKEGV 2895
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.128 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,630,196
Number of Sequences: 37866
Number of extensions: 1089547
Number of successful extensions: 8541
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 549
Number of HSP's that attempted gapping in prelim test: 5822
Number of HSP's gapped (non-prelim): 1995
length of query: 678
length of database: 18,247,518
effective HSP length: 109
effective length of query: 569
effective length of database: 14,120,124
effective search space: 8034350556
effective search space used: 8034350556
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.