BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [Homo sapiens] (678 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [... 1330 0.0 gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 1265 0.0 gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 672 0.0 gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 672 0.0 gi|67782321 spectrin beta isoform a [Homo sapiens] 577 e-165 gi|67782319 spectrin beta isoform b [Homo sapiens] 577 e-165 gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 531 e-150 gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 269 7e-72 gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 203 4e-52 gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 203 4e-52 gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 185 1e-46 gi|221316624 dystonin isoform 4 [Homo sapiens] 97 5e-20 gi|221316622 dystonin isoform 3 [Homo sapiens] 97 5e-20 gi|221316618 dystonin isoform 2 [Homo sapiens] 97 5e-20 gi|34577047 dystonin isoform 1 [Homo sapiens] 97 5e-20 gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 97 5e-20 gi|33188443 microfilament and actin filament cross-linker protei... 84 4e-16 gi|33188445 microfilament and actin filament cross-linker protei... 84 4e-16 gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 78 3e-14 gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 78 3e-14 gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 77 5e-14 gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 75 2e-13 gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 75 3e-13 gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 74 4e-13 gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 74 4e-13 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 70 5e-12 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 70 5e-12 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 70 5e-12 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 70 5e-12 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 70 5e-12 >gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [Homo sapiens] Length = 678 Score = 1330 bits (3441), Expect = 0.0 Identities = 678/678 (100%), Positives = 678/678 (100%) Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK Sbjct: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT Sbjct: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL Sbjct: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180 Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI Sbjct: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE Sbjct: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC Sbjct: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA Sbjct: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420 Query: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT Sbjct: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480 Query: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP Sbjct: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540 Query: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW Sbjct: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600 Query: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGLPASP 660 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGLPASP Sbjct: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGLPASP 660 Query: 661 WWPTPATPSPLTAPFSME 678 WWPTPATPSPLTAPFSME Sbjct: 661 WWPTPATPSPLTAPFSME 678 >gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo sapiens] Length = 2564 Score = 1265 bits (3273), Expect = 0.0 Identities = 650/653 (99%), Positives = 651/653 (99%) Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK Sbjct: 1325 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 1384 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT Sbjct: 1385 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 1444 Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL Sbjct: 1445 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 1504 Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI Sbjct: 1505 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 1564 Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE Sbjct: 1565 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 1624 Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC Sbjct: 1625 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 1684 Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA Sbjct: 1685 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 1744 Query: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT Sbjct: 1745 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 1804 Query: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP Sbjct: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864 Query: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW Sbjct: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 1924 Query: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPR SS+ Sbjct: 1925 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSV 1977 Score = 149 bits (376), Expect = 8e-36 Identities = 164/667 (24%), Positives = 274/667 (41%), Gaps = 48/667 (7%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 +H+A A++A +E ++ + Q L E V + + + WA L A+ Sbjct: 470 KHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRT 529 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +L + ++ Q + + M++QL + G L + L+K +E + Sbjct: 530 RLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSE 589 Query: 141 EVGELQAQTAALP----LEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 V L A +P +++ R N V L L E RR L AS+ L + Sbjct: 590 RVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWAL 649 Query: 197 AHDLDDELAWVQERLPLAMQTERGNG----------------------LQAVQQHIKKNQ 234 +L++ +W +++ L ++ G G L A + ++ Sbjct: 650 LQELEEAESWARDKERL-LEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGEL 708 Query: 235 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR-GL-EQLQSA---WAGLREAAERR 289 G RR + R E L AG P A+ V GL E+ SA W L EAA RR Sbjct: 709 GGRRALLQQALRCGEELVAAGGAVG---PGADTVHLVGLAERAASARRRWQRLEEAAARR 765 Query: 290 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349 ++ L A + Q+ D+ + WL + L + D G DE S+ +L ++H L VE + Sbjct: 766 ERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAH 825 Query: 350 EESIAQLSRQCRAL--LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQ 407 ++ L RQ L P + R + ++L+ + E+ RR L +Y+ Sbjct: 826 RGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYR 885 Query: 408 LSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467 + +V E WI EKE S + + V V+Q +F E R+ VN V Sbjct: 886 MFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSL-MGRVLDVNHTV 944 Query: 468 DELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527 EL+E GH ++ + +D LN W ++EL+ R + ++A + + E++ Q+ Sbjct: 945 QELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVR 1004 Query: 528 EKRRRLPRLTTPPEPRPSA-SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586 EKRR + E P A ++Q L E LQ L + L E AA L + + A Sbjct: 1005 EKRRAV-------ESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQ-A 1056 Query: 587 EAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADK 646 + +E+ W L SA + V++ RF + L W+ G ++ Sbjct: 1057 ARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEG 1116 Query: 647 PRCPSSL 653 P P+SL Sbjct: 1117 P-LPNSL 1122 Score = 84.0 bits (206), Expect = 4e-16 Identities = 96/395 (24%), Positives = 163/395 (41%), Gaps = 52/395 (13%) Query: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229 G+R+ ++L+ + E +++ +EL A +L LAW+ + L + N L VQQ Sbjct: 294 GKRIGKVLDQVLEVGKIIERYEEL---AAEL---LAWIHRTVGLISNQKFANSLSGVQQQ 347 Query: 230 IKKNQG---LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR--------GLEQLQSA 278 ++ L + ++ EVL L S++S RR G+ + A Sbjct: 348 LQAFTAYCTLEKPVKFQEKGNLEVL-----LFSIQSKLRACNRRLFVPREGCGIWDIDKA 402 Query: 279 WAGL------REAAERRQQVLDAAFQVEQYYFD--VAEVEAWLGEQELLMMSEDKGKDEQ 330 W L REAA R + + ++ FD VA E+WL E + L+ ++ G + Sbjct: 403 WGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELP 462 Query: 331 STLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE 390 + +KKH +E + YEE + ++ +AL G+ D +++ ++ V R + L Sbjct: 463 AVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTG 522 Query: 391 LGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS 450 L RR LEQ L ++ +++ + W+ E + S E GQ L +K Sbjct: 523 LVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEG 582 Query: 451 ETGMAGRERLAAVN------------QMVDELIECGHTAAATMAEWKDGLNEAWAELLEL 498 + A ER+ A+N Q D + C + ++ AEL E Sbjct: 583 DIA-AQSERVEALNAAALRFSQLQGYQPCDPQVICNRV---------NHVHGCLAELQEQ 632 Query: 499 MGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 533 R L ASR L + E + +K R L Sbjct: 633 AARRRAELEASRSLWALLQELEEAESWARDKERLL 667 Score = 78.6 bits (192), Expect = 2e-14 Identities = 67/329 (20%), Positives = 143/329 (43%), Gaps = 3/329 (0%) Query: 33 KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLV 92 +E L + + +L++ AA++ + + + WAEL +A+ L + + + Sbjct: 1781 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 1840 Query: 93 QSFAELDKKLLHMESQLQDVD-PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 151 EL ++ +L + P + +S + L++ E ++ +V +LQ A Sbjct: 1841 SDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 1900 Query: 152 LPLEPASK--ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQE 209 L A + E + R+ V + LL ++ R + ++ + + + D L+W+ Sbjct: 1901 LRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDG 1960 Query: 210 RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR 269 ++ + +V+ + +QGL+ E++A P L E +L +S A+ ++ Sbjct: 1961 IASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ 2020 Query: 270 RGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE 329 L++L + + E +R + L +V Q+ + +AWL QE L+ S + G Sbjct: 2021 AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSV 2080 Query: 330 QSTLQLLKKHLQLEQGVENYEESIAQLSR 358 QL+++H + +EE + L R Sbjct: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRR 2109 Score = 75.1 bits (183), Expect = 2e-13 Identities = 90/476 (18%), Positives = 201/476 (42%), Gaps = 17/476 (3%) Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 +LM + +D + +H + +E + ++ R+ + L++ + + ++ Sbjct: 1642 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRR 1701 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 ++ + + L+ + + L + QL + +EL+ + E + G D Sbjct: 1702 QSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEH 1761 Query: 121 VNSQLKKLQSMESQVEEWYRE--VGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178 V+ +K S+ RE Q + + + E ++ + E LLE Sbjct: 1762 VSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLE 1821 Query: 179 PLQERRRLLLASKELHQV---AHDLDDELAWVQERLP-LAMQTERGNGLQAVQQHIKKNQ 234 + R +LL AS+ELH+ A +L ++ + RLP L E ++Q+ ++ Sbjct: 1822 LMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR--- 1878 Query: 235 GLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVL 293 ++Q ++ ++ E A L ++ + E AEA+ +++ W L A E + + Sbjct: 1879 AFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHV 1938 Query: 294 DAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI 353 + +++ V ++ +W+ + + DK +D S L+ H L+ +E + Sbjct: 1939 SSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPEL 1998 Query: 354 AQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE---RRVALEQQYWLYQLSR 410 R+LL +++I Q+Q+D+L +E+ E+ L+Q ++Q ++ Sbjct: 1999 TTCQELGRSLLLNKSAMADEI---QAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQ 2055 Query: 411 QVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQM 466 + + W+ +E + S ELG + V L + F + A ER +++ ++ Sbjct: 2056 EAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF-RKAAAAWEERFSSLRRL 2110 Score = 72.8 bits (177), Expect = 1e-12 Identities = 120/631 (19%), Positives = 261/631 (41%), Gaps = 31/631 (4%) Query: 42 EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF-AELDK 100 E L + P AA + + E+ W L S QA + A + + + A LD Sbjct: 1044 EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDW 1103 Query: 101 KLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK 159 + E+ P L ++ L + +++ +V++ + + A + AL ++ Sbjct: 1104 LVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAE 1163 Query: 160 ELVGERQNAVGERLVRL------LEPLQERRRLLLASKELHQV-AHDLDDELAWVQERLP 212 G A+ E L L L L E RR L ++Q+ DL L ++ + Sbjct: 1164 LGPGL---ALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEM 1220 Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL---ASLRSPEA-EAV 268 E +++V++ +K+++ ++ +++ ++ A L ++ +A EAV Sbjct: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAV 1280 Query: 269 RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKD 328 R LE+ Q + A++ Q L +++ + D E++ W+ E+ +LM + +D Sbjct: 1281 TRLLEKNQEN----QLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEK-MLMARDGTRED 1335 Query: 329 EQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVAL 388 + +H + +E + ++ R+ + L++ + + ++ ++ + + L Sbjct: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAEL 1395 Query: 389 KELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEF 448 + + + L + QL + +EL+ + E + G D V+ +K Sbjct: 1396 ESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455 Query: 449 ASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAA 508 S+ RE Q + + + E ++ + E LLE + R +LL A Sbjct: 1456 ESQVEEWYRE--VGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLA 1513 Query: 509 SRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQLLVS 565 S+ELH+ A +L ++ + RLP L E ++Q+ ++ ++Q Sbjct: 1514 SKELHQV---AHDLDDELAWVQERLP-LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 1569 Query: 566 QVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHS 625 ++ ++ E A L ++ + E AEA+ +++ W L A E + + + +++ Sbjct: 1570 RLEEVLERAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 1628 Query: 626 QVRDLLSWMDGIASQIGAADKPRCPSSLLGL 656 V ++ +W+ + + DK + S L L Sbjct: 1629 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQL 1659 Score = 69.3 bits (168), Expect = 1e-11 Identities = 112/605 (18%), Positives = 228/605 (37%), Gaps = 32/605 (5%) Query: 44 QQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL 103 Q+L++ + VR + W + + + ++ + V AE+ ++ Sbjct: 945 QELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVR 1004 Query: 104 HMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVG 163 ++ G + +L L++ +E R+ L+ PA + Sbjct: 1005 EKRRAVESAPRAG--GALQWRLSGLEAALQALEP--RQAALLEEAALLAERFPAQAARLH 1060 Query: 164 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERG--N 221 + +G L Q + A+ L + HDLD L W+ A +E N Sbjct: 1061 QGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPN 1120 Query: 222 GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE---AVRRGLEQLQSA 278 L+ + ++ L+ E+ ++ + AL + E A+ L L+ Sbjct: 1121 SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELG 1180 Query: 279 WAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKK 338 W L E R++ L A + + D+ + L QE+ + + +S + LK+ Sbjct: 1181 WHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQ 1240 Query: 339 HLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVA 398 H +E ++ + + LL G+ EQ Q V RL L + + Sbjct: 1241 HRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQ---AQEAVTRL------LEKNQENQ 1291 Query: 399 LEQQYWLYQLSRQVS---------ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFA 449 L Q W+ +L Q+ EL+ WI EK ++A +D + + F Sbjct: 1292 LRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMA-RDGTREDNHKLHKRWLRHQAFM 1350 Query: 450 SETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAAS 509 +E +E L + + +L++ AA++ + + + WAEL +A+ L + Sbjct: 1351 AELAQ-NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEA 1409 Query: 510 RELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQ 569 + + EL ++ +L + P + +S + L++ E ++ +V + Sbjct: 1410 SKADQLVQSFAELDKKLLHMESQLQDV-DPGGDLATVNSQLKKLQSMESQVEEWYREVGE 1468 Query: 570 LQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRD 629 LQ A L A + E + R+ V + LL ++ R + ++ + + + D Sbjct: 1469 LQAQTAALPLEPASK--ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDD 1526 Query: 630 LLSWM 634 L+W+ Sbjct: 1527 ELAWV 1531 >gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo sapiens] Length = 2155 Score = 672 bits (1734), Expect = 0.0 Identities = 346/654 (52%), Positives = 465/654 (71%), Gaps = 3/654 (0%) Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 ML A+D + ++ LH +WL+HQAFMAELA NKEWL+KIE+EG QL+ EKPE A V++K Sbjct: 1282 MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEK 1341 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 L + + W LESTTQ KA++LF+A+KA+ QS A+LDK L +ESQ+Q D G DL + Sbjct: 1342 LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTS 1401 Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180 VN LKK Q +E+Q+E +E+ ELQ+Q AL E S + V ++ V + + LLEPL Sbjct: 1402 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1461 Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 ER+ LLASKE+HQ D++DE+ WV ER+PLA T+ G+ LQ VQ IKKNQ L++EI Sbjct: 1462 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEI 1521 Query: 241 QAHGPRLEEVLERA-GALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV 299 Q H PR++++ ER+ + S AEA+R+ L L+ W L E E+R + L+ A + Sbjct: 1522 QGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRA 1581 Query: 300 EQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ 359 +QYYFD AE EAW+ EQEL MMSE+K KDEQS + +LKKH LEQ VE+Y E++ QLS+ Sbjct: 1582 QQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKT 1641 Query: 360 CRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419 RAL+ HP+SE+IS RQS+VD+LY LK+L EERR L++++ L+QL+R+V +LE WI Sbjct: 1642 SRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWI 1701 Query: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479 AE+EVVAGS ELGQD+EHV++LQE+F EFA +TG G+ER+ VN + DELI GH+ AA Sbjct: 1702 AEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAA 1761 Query: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539 T+AEWKDGLNEAWA+LLEL+ TR Q+LAAS ELHKF+ DA+E+ G+I++K ++LP Sbjct: 1762 TIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE--EL 1819 Query: 540 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599 + + ++QR FEHD+Q L +QVRQLQE AA+L+ YAG+ A+ I RE EVL+ Sbjct: 1820 GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEA 1879 Query: 600 WKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653 WK LL ACE R+ + T D RF S VRDL+ WM+ + QI A +KPR SS+ Sbjct: 1880 WKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1933 Score = 191 bits (485), Expect = 2e-48 Identities = 138/651 (21%), Positives = 285/651 (43%), Gaps = 8/651 (1%) Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61 L+++D D + +H+A ++A +E ++ + ++L E + + Sbjct: 431 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 490 Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121 + + W L +A+ ++L ++ Q + + M+ + D G L V Sbjct: 491 DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGV 550 Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLE-----PASKELVGERQNAVGERLVRL 176 L+K +E+ + V + A + P +++ +R + L Sbjct: 551 EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 610 Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236 + ERR L S+ L + ++ +E W++E+ + + G L +V + + K++ Sbjct: 611 CQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAF 670 Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296 E+ E+ ++ + + +E +R + ++ WA L + + R++ L+ A Sbjct: 671 EDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 730 Query: 297 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 356 + Q+ D +++AW+ + ++ S D G DE ST L+KKH + + + NY ++ L Sbjct: 731 SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTL 790 Query: 357 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 416 Q A L H +S + R S ++ Y + EL R+ AL+ LY++ + E Sbjct: 791 HEQASA-LPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACE 849 Query: 417 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 476 WI EKE + ++ + E + V+Q +F E R+A VNQ+ +L+ GH Sbjct: 850 LWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQA-SRVAVVNQIARQLMHSGHP 908 Query: 477 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 536 + + +D LN W++ EL+ + L ++ + + + E + I EK + + Sbjct: 909 SEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIEST 968 Query: 537 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 596 ++QR L E DL + +++ LQ+ A +L + + + A+AI SR E+ Sbjct: 969 QDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEI 1027 Query: 597 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647 W+E+ + ++ + + +F + D SW+ + I + D P Sbjct: 1028 SDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMP 1078 Score = 133 bits (335), Expect = 5e-31 Identities = 135/638 (21%), Positives = 275/638 (43%), Gaps = 28/638 (4%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 +H+ E+A + L+ + + L QE E + VR +L I + + E+ T+ + + Sbjct: 772 KHKDVAEEIANYRPTLDTLHEQASALPQEHAE-SPDVRGRLSGIEERYKEVAELTRLRKQ 830 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 L + L + F+E D L ++ + Q ++ + +L+ L+ ++ + E Sbjct: 831 ALQDTLA---LYKMFSEADACELWIDEKEQWLNN----MQIPEKLEDLEVIQHRFESLEP 883 Query: 141 EVGELQAQTAALPL---------EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASK 191 E+ ++ A + P+ KE+ + Q+ + R + E + ++ LL++ Sbjct: 884 EMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQ-QDKLNTRWSQFRELVDRKKDALLSAL 942 Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTER-GNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 + + ++ +W++E+ + T+ GN L V +K G+ R++ A +L ++ Sbjct: 943 SIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL 1002 Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVE 310 + A L S +A+A+ L ++ W ++ + R+ L A +++Q+ D+ + + Sbjct: 1003 QKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ 1062 Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 +WL + + SED +LL +H ++ ++NYEE Q R ++ G D Sbjct: 1063 SWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDY-QKMRDMGEMVTQGQTD 1121 Query: 371 SEQISRRQ--SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 428 ++ + RQ +D + L ++ E R+ L Q + Q R + E ++ +E V Sbjct: 1122 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1181 Query: 429 PELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGL 488 E+ E +K +F + T A E++ AV + L+ G+ + + E D + Sbjct: 1182 TEMPTTLEGAEAAIKKQEDFMT-TMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSI 1240 Query: 489 NEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 548 ++ + E L +R+L KF D +EL I EK L + + S Sbjct: 1241 DDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEK--MLTAQDMSYDEARNLHS 1298 Query: 549 MQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL-QGWKELLSAC 607 +AF +L + ++++ QL + EA+ + L + W+ L S Sbjct: 1299 KWLKHQAFMAELASNKEWLDKIEKEGMQL--ISEKPETEAVVKEKLTGLHKMWEVLESTT 1356 Query: 608 EDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645 + + A F DL W+ G+ SQI + D Sbjct: 1357 QTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDD 1394 Score = 100 bits (249), Expect = 4e-21 Identities = 119/500 (23%), Positives = 212/500 (42%), Gaps = 39/500 (7%) Query: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229 G+R+ ++L+ E +++ ++ +A DL L W+++ + + + N L VQQ Sbjct: 274 GKRIGKVLDNAIETEKMI---EKYESLASDL---LEWIEQTIIILNNRKFANSLVGVQQQ 327 Query: 230 IKKNQGLRREIQ----AHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGLR 283 ++ R + LE +L + + + R G + + AW L Sbjct: 328 LQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLE 387 Query: 284 EAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQL 335 +A R+ L ++EQ FD A E WL E + L+ ++ G D + Sbjct: 388 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 447 Query: 336 LKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEER 395 KKH +E + YEE + + R L + D ++I+ R+ V RL+ L EL R Sbjct: 448 TKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRAR 507 Query: 396 RVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMA 455 R LE L ++ +++ + W+ E +V+ S + G+ V L +K + ++ G+ Sbjct: 508 RQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQ 567 Query: 456 GRERLAAVNQMVDELIECGH----TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511 ER+ VN + G + + + + EL +L R L SR Sbjct: 568 A-ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRR 626 Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVR 568 L KFF + E +G I EK ++ + + +S+ R L RAFE ++ Sbjct: 627 LWKFFWEMAEEEGWIREKE----KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFE 682 Query: 569 Q-LQEGAAQLRTVYAGEHAEAIASREQEVLQGWKEL--LSACEDARLHVSSTADALRFHS 625 Q ++EG + + G +E I R + + W L LSA RL +S +F + Sbjct: 683 QAIKEGEDMIAEEHFG--SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH--QFQA 738 Query: 626 QVRDLLSWMDGIASQIGAAD 645 D+ +WM I + ++D Sbjct: 739 DADDIDAWMLDILKIVSSSD 758 Score = 95.9 bits (237), Expect = 1e-19 Identities = 93/464 (20%), Positives = 200/464 (43%), Gaps = 22/464 (4%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 +HQ + E + ++ + + L+ + + + + ++ + +A L+ + + Sbjct: 1620 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRG 1679 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +L E + QL + +L++ + E + G D V ++ + E+ R Sbjct: 1680 KLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTM-------LQERFREFAR 1732 Query: 141 EVGELQAQTAALPLEPASKELVG----------ERQNAVGERLVRLLEPLQERRRLLLAS 190 + G + Q + + EL+ E ++ + E LLE + R ++L AS Sbjct: 1733 DTGNI-GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAAS 1791 Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 ELH+ HD + +Q++ + E G V+ + + +IQA G ++ ++ Sbjct: 1792 YELHKFYHDAKEIFGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQL 1850 Query: 251 LERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 E A L A+ +A+ +++ ++ AW L +A E R+ L +++ V ++ Sbjct: 1851 QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDL 1910 Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369 W+ + + +++K +D S L+ H ++ ++ +S ++LL H Sbjct: 1911 MLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHY 1970 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429 SE+I + Q+ + + E+R L ++Q SR S E W+ +E S Sbjct: 1971 ASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSR 2030 Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD-ELIE 472 E+GQ + V L ++ F ++ ER +A+ ++ EL+E Sbjct: 2031 EIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLE 2073 Score = 85.5 bits (210), Expect = 1e-16 Identities = 79/385 (20%), Positives = 162/385 (42%), Gaps = 10/385 (2%) Query: 33 KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLV 92 +E ++ + +L+ AA++ + + + WA+L + + L + + + Sbjct: 1739 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFY 1798 Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152 E+ ++ +L + + G D TV + + + E ++ +V +LQ A L Sbjct: 1799 HDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL 1857 Query: 153 PLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQER 210 A + + +R+N V E LL+ + RR L+ + + + + D + W+++ Sbjct: 1858 QAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDV 1917 Query: 211 LPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR 270 + E+ + +V+ + +QG++ EI A +E +L + + +E ++ Sbjct: 1918 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1977 Query: 271 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQ 330 L QL + + E R + L +V Q+ D + EAWL QE + S + G+ Sbjct: 1978 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD 2037 Query: 331 STLQLLKKHLQLEQGVENYEESIAQLSR-QCRALLEMGHPDSEQISRRQSQVDRLYVALK 389 +L+K+H E+ ++E + L R LLE+ E+ +R+ + Sbjct: 2038 EVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2097 Query: 390 ELGEERRVALEQQYWLYQLSRQVSE 414 E E QQ W QVS+ Sbjct: 2098 EEAE------SQQQWDTSKGEQVSQ 2116 Score = 30.0 bits (66), Expect = 7.3 Identities = 48/291 (16%), Positives = 107/291 (36%), Gaps = 20/291 (6%) Query: 364 LEMGHPDSEQISRRQ-------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 416 + + HPD + I S++ L V K +G+ A+E + + + S+L Sbjct: 243 ISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL 302 Query: 417 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS---ETGMAGRERLAAVNQMVDELIEC 473 WI + ++ + + V + F+ + + + L + + + Sbjct: 303 EWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRA 362 Query: 474 GHTAAATMAEWK--DGLNEAW-----AELLELMGTRAQLLAASR--ELHKFFSDARELQG 524 + E K +N+AW AE + R +L+ + +L + F ++ Sbjct: 363 NNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRE 422 Query: 525 QIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGE 584 + +RL P+ + + A E D+ +V+ + A +L + Sbjct: 423 TWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHD 482 Query: 585 HAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635 + I +R+ V++ W+ LL R + + ++ ++ WMD Sbjct: 483 -IKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMD 532 >gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo sapiens] Length = 2364 Score = 672 bits (1734), Expect = 0.0 Identities = 346/654 (52%), Positives = 465/654 (71%), Gaps = 3/654 (0%) Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 ML A+D + ++ LH +WL+HQAFMAELA NKEWL+KIE+EG QL+ EKPE A V++K Sbjct: 1295 MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEK 1354 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 L + + W LESTTQ KA++LF+A+KA+ QS A+LDK L +ESQ+Q D G DL + Sbjct: 1355 LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTS 1414 Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180 VN LKK Q +E+Q+E +E+ ELQ+Q AL E S + V ++ V + + LLEPL Sbjct: 1415 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1474 Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 ER+ LLASKE+HQ D++DE+ WV ER+PLA T+ G+ LQ VQ IKKNQ L++EI Sbjct: 1475 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEI 1534 Query: 241 QAHGPRLEEVLERA-GALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV 299 Q H PR++++ ER+ + S AEA+R+ L L+ W L E E+R + L+ A + Sbjct: 1535 QGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRA 1594 Query: 300 EQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ 359 +QYYFD AE EAW+ EQEL MMSE+K KDEQS + +LKKH LEQ VE+Y E++ QLS+ Sbjct: 1595 QQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKT 1654 Query: 360 CRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419 RAL+ HP+SE+IS RQS+VD+LY LK+L EERR L++++ L+QL+R+V +LE WI Sbjct: 1655 SRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWI 1714 Query: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479 AE+EVVAGS ELGQD+EHV++LQE+F EFA +TG G+ER+ VN + DELI GH+ AA Sbjct: 1715 AEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAA 1774 Query: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539 T+AEWKDGLNEAWA+LLEL+ TR Q+LAAS ELHKF+ DA+E+ G+I++K ++LP Sbjct: 1775 TIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPE--EL 1832 Query: 540 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599 + + ++QR FEHD+Q L +QVRQLQE AA+L+ YAG+ A+ I RE EVL+ Sbjct: 1833 GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEA 1892 Query: 600 WKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653 WK LL ACE R+ + T D RF S VRDL+ WM+ + QI A +KPR SS+ Sbjct: 1893 WKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1946 Score = 191 bits (485), Expect = 2e-48 Identities = 138/651 (21%), Positives = 285/651 (43%), Gaps = 8/651 (1%) Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61 L+++D D + +H+A ++A +E ++ + ++L E + + Sbjct: 444 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503 Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121 + + W L +A+ ++L ++ Q + + M+ + D G L V Sbjct: 504 DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGV 563 Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLE-----PASKELVGERQNAVGERLVRL 176 L+K +E+ + V + A + P +++ +R + L Sbjct: 564 EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 623 Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236 + ERR L S+ L + ++ +E W++E+ + + G L +V + + K++ Sbjct: 624 CQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAF 683 Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296 E+ E+ ++ + + +E +R + ++ WA L + + R++ L+ A Sbjct: 684 EDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 743 Query: 297 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 356 + Q+ D +++AW+ + ++ S D G DE ST L+KKH + + + NY ++ L Sbjct: 744 SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTL 803 Query: 357 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 416 Q A L H +S + R S ++ Y + EL R+ AL+ LY++ + E Sbjct: 804 HEQASA-LPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACE 862 Query: 417 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 476 WI EKE + ++ + E + V+Q +F E R+A VNQ+ +L+ GH Sbjct: 863 LWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQA-SRVAVVNQIARQLMHSGHP 921 Query: 477 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 536 + + +D LN W++ EL+ + L ++ + + + E + I EK + + Sbjct: 922 SEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIEST 981 Query: 537 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 596 ++QR L E DL + +++ LQ+ A +L + + + A+AI SR E+ Sbjct: 982 QDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEI 1040 Query: 597 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647 W+E+ + ++ + + +F + D SW+ + I + D P Sbjct: 1041 SDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMP 1091 Score = 133 bits (335), Expect = 5e-31 Identities = 135/638 (21%), Positives = 275/638 (43%), Gaps = 28/638 (4%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 +H+ E+A + L+ + + L QE E + VR +L I + + E+ T+ + + Sbjct: 785 KHKDVAEEIANYRPTLDTLHEQASALPQEHAE-SPDVRGRLSGIEERYKEVAELTRLRKQ 843 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 L + L + F+E D L ++ + Q ++ + +L+ L+ ++ + E Sbjct: 844 ALQDTLA---LYKMFSEADACELWIDEKEQWLNN----MQIPEKLEDLEVIQHRFESLEP 896 Query: 141 EVGELQAQTAALPL---------EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASK 191 E+ ++ A + P+ KE+ + Q+ + R + E + ++ LL++ Sbjct: 897 EMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQ-QDKLNTRWSQFRELVDRKKDALLSAL 955 Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTER-GNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 + + ++ +W++E+ + T+ GN L V +K G+ R++ A +L ++ Sbjct: 956 SIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL 1015 Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVE 310 + A L S +A+A+ L ++ W ++ + R+ L A +++Q+ D+ + + Sbjct: 1016 QKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ 1075 Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 +WL + + SED +LL +H ++ ++NYEE Q R ++ G D Sbjct: 1076 SWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDY-QKMRDMGEMVTQGQTD 1134 Query: 371 SEQISRRQ--SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 428 ++ + RQ +D + L ++ E R+ L Q + Q R + E ++ +E V Sbjct: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194 Query: 429 PELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGL 488 E+ E +K +F + T A E++ AV + L+ G+ + + E D + Sbjct: 1195 TEMPTTLEGAEAAIKKQEDFMT-TMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSI 1253 Query: 489 NEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 548 ++ + E L +R+L KF D +EL I EK L + + S Sbjct: 1254 DDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEK--MLTAQDMSYDEARNLHS 1311 Query: 549 MQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL-QGWKELLSAC 607 +AF +L + ++++ QL + EA+ + L + W+ L S Sbjct: 1312 KWLKHQAFMAELASNKEWLDKIEKEGMQL--ISEKPETEAVVKEKLTGLHKMWEVLESTT 1369 Query: 608 EDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645 + + A F DL W+ G+ SQI + D Sbjct: 1370 QTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDD 1407 Score = 100 bits (249), Expect = 4e-21 Identities = 119/500 (23%), Positives = 212/500 (42%), Gaps = 39/500 (7%) Query: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229 G+R+ ++L+ E +++ ++ +A DL L W+++ + + + N L VQQ Sbjct: 287 GKRIGKVLDNAIETEKMI---EKYESLASDL---LEWIEQTIIILNNRKFANSLVGVQQQ 340 Query: 230 IKKNQGLRREIQ----AHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGLR 283 ++ R + LE +L + + + R G + + AW L Sbjct: 341 LQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLE 400 Query: 284 EAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQL 335 +A R+ L ++EQ FD A E WL E + L+ ++ G D + Sbjct: 401 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 460 Query: 336 LKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEER 395 KKH +E + YEE + + R L + D ++I+ R+ V RL+ L EL R Sbjct: 461 TKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRAR 520 Query: 396 RVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMA 455 R LE L ++ +++ + W+ E +V+ S + G+ V L +K + ++ G+ Sbjct: 521 RQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQ 580 Query: 456 GRERLAAVNQMVDELIECGH----TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511 ER+ VN + G + + + + EL +L R L SR Sbjct: 581 A-ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRR 639 Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVR 568 L KFF + E +G I EK ++ + + +S+ R L RAFE ++ Sbjct: 640 LWKFFWEMAEEEGWIREKE----KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFE 695 Query: 569 Q-LQEGAAQLRTVYAGEHAEAIASREQEVLQGWKEL--LSACEDARLHVSSTADALRFHS 625 Q ++EG + + G +E I R + + W L LSA RL +S +F + Sbjct: 696 QAIKEGEDMIAEEHFG--SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH--QFQA 751 Query: 626 QVRDLLSWMDGIASQIGAAD 645 D+ +WM I + ++D Sbjct: 752 DADDIDAWMLDILKIVSSSD 771 Score = 95.9 bits (237), Expect = 1e-19 Identities = 93/464 (20%), Positives = 200/464 (43%), Gaps = 22/464 (4%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 +HQ + E + ++ + + L+ + + + + ++ + +A L+ + + Sbjct: 1633 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRG 1692 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +L E + QL + +L++ + E + G D V ++ + E+ R Sbjct: 1693 KLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTM-------LQERFREFAR 1745 Query: 141 EVGELQAQTAALPLEPASKELVG----------ERQNAVGERLVRLLEPLQERRRLLLAS 190 + G + Q + + EL+ E ++ + E LLE + R ++L AS Sbjct: 1746 DTGNI-GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAAS 1804 Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 ELH+ HD + +Q++ + E G V+ + + +IQA G ++ ++ Sbjct: 1805 YELHKFYHDAKEIFGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQL 1863 Query: 251 LERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 E A L A+ +A+ +++ ++ AW L +A E R+ L +++ V ++ Sbjct: 1864 QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDL 1923 Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369 W+ + + +++K +D S L+ H ++ ++ +S ++LL H Sbjct: 1924 MLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHY 1983 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429 SE+I + Q+ + + E+R L ++Q SR S E W+ +E S Sbjct: 1984 ASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSR 2043 Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD-ELIE 472 E+GQ + V L ++ F ++ ER +A+ ++ EL+E Sbjct: 2044 EIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLE 2086 Score = 85.5 bits (210), Expect = 1e-16 Identities = 79/385 (20%), Positives = 162/385 (42%), Gaps = 10/385 (2%) Query: 33 KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLV 92 +E ++ + +L+ AA++ + + + WA+L + + L + + + Sbjct: 1752 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFY 1811 Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152 E+ ++ +L + + G D TV + + + E ++ +V +LQ A L Sbjct: 1812 HDAKEIFGRIQDKHKKLPE-ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL 1870 Query: 153 PLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQER 210 A + + +R+N V E LL+ + RR L+ + + + + D + W+++ Sbjct: 1871 QAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDV 1930 Query: 211 LPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR 270 + E+ + +V+ + +QG++ EI A +E +L + + +E ++ Sbjct: 1931 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1990 Query: 271 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQ 330 L QL + + E R + L +V Q+ D + EAWL QE + S + G+ Sbjct: 1991 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD 2050 Query: 331 STLQLLKKHLQLEQGVENYEESIAQLSR-QCRALLEMGHPDSEQISRRQSQVDRLYVALK 389 +L+K+H E+ ++E + L R LLE+ E+ +R+ + Sbjct: 2051 EVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2110 Query: 390 ELGEERRVALEQQYWLYQLSRQVSE 414 E E QQ W QVS+ Sbjct: 2111 EEAE------SQQQWDTSKGEQVSQ 2129 Score = 30.0 bits (66), Expect = 7.3 Identities = 48/291 (16%), Positives = 107/291 (36%), Gaps = 20/291 (6%) Query: 364 LEMGHPDSEQISRRQ-------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 416 + + HPD + I S++ L V K +G+ A+E + + + S+L Sbjct: 256 ISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL 315 Query: 417 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS---ETGMAGRERLAAVNQMVDELIEC 473 WI + ++ + + V + F+ + + + L + + + Sbjct: 316 EWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRA 375 Query: 474 GHTAAATMAEWK--DGLNEAW-----AELLELMGTRAQLLAASR--ELHKFFSDARELQG 524 + E K +N+AW AE + R +L+ + +L + F ++ Sbjct: 376 NNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRE 435 Query: 525 QIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGE 584 + +RL P+ + + A E D+ +V+ + A +L + Sbjct: 436 TWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHD 495 Query: 585 HAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635 + I +R+ V++ W+ LL R + + ++ ++ WMD Sbjct: 496 -IKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMD 545 >gi|67782321 spectrin beta isoform a [Homo sapiens] Length = 2328 Score = 577 bits (1488), Expect = e-165 Identities = 304/653 (46%), Positives = 424/653 (64%), Gaps = 8/653 (1%) Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 +L ++D + ++ LH +WL+HQAF+AELA ++ WLE I+ EG+QLM EKP+ A V +K Sbjct: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQK 1353 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 L + + W EL++TT+ K + L A +D +Q+ A+L+K + ME QL+ DPG DL + Sbjct: 1354 LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTS 1413 Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180 VN L KL+ +E QV E+GEL AQ P+ E G+ ++ +R + LLEPL Sbjct: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQV------PSMGEEGGDADLSIEKRFLDLLEPL 1467 Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 R++ L +S+ Q++ DL+DE WV+ERLPLA + G LQ VQ +KKNQ L+ EI Sbjct: 1468 GRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEI 1527 Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 H PR+E+VL+R L + + + L LQS+W LREAA R Q L A + + Sbjct: 1528 LGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQ 1587 Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 QYY D E EAW+GEQEL ++S++ KDE+ + +LK+HL+ ++ VE+Y +I QL+ + Sbjct: 1588 QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA 1647 Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420 + LL GHP+ EQI R Q QVD+ Y LK++ EER+ LE Y L+QL R+ +LE WI+ Sbjct: 1648 QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWIS 1707 Query: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480 EKE+VA SPE+GQDF+HV++L++KF +FA ETG G+ER+ VN ++ LI+ GH+ AAT Sbjct: 1708 EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT 1767 Query: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540 +AEWKDGLNE WA+LLEL+ TR QLLAAS +LH++F E+ G I+EK R LP Sbjct: 1768 IAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE--DVG 1825 Query: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600 +A S R AFE +L LL QV+Q Q+ A +L+T YAGE AEAI ++EQEV W Sbjct: 1826 LDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAW 1885 Query: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653 + LL AC R + TAD RF S RDLLSWM+ I QI ++PR SS+ Sbjct: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSV 1938 Score = 161 bits (407), Expect = 2e-39 Identities = 131/650 (20%), Positives = 274/650 (42%), Gaps = 7/650 (1%) Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61 L+A+D D + +H+A + A +E + +E Q+L +E + + Sbjct: 444 LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503 Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121 I + W+ L+ Q++ ++L +L Q + +++ L + G L V Sbjct: 504 DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563 Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALP----LEPASKELVGERQNAVGERLVRLL 177 L+K + ME+ + +V + A T +P +++ +R + + + L Sbjct: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623 Query: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237 R+ L SK L + ++D+ +W++E+ + + G L +V +K++ Sbjct: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683 Query: 238 REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297 E++ LE++ + A + + + + ++++ + W L++ A ++ L A Sbjct: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAE 743 Query: 298 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357 Q+ D +++AWL + L+ ED G+DE +T L KKH + +E + L Sbjct: 744 NFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLE 803 Query: 358 RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEH 417 +Q + E DS ++ R + LY + + R+ L++ LY + + E Sbjct: 804 QQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACEL 862 Query: 418 WIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTA 477 W+ EKE E+ E + V+Q +F E ++ VN + L+E GH Sbjct: 863 WMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL-MTQIDGVNLAANSLVESGHPR 921 Query: 478 AATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537 + + +++D LN W L+ R + + ++ +H + D E I +K + + Sbjct: 922 SREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK 981 Query: 538 TPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL 597 ++QR L E D+ + ++V L+ + QL + E E I R++ + Sbjct: 982 DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLE 1040 Query: 598 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647 + W+ L + + + + F + D +W+ + + D P Sbjct: 1041 ELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMP 1090 Score = 105 bits (261), Expect = 2e-22 Identities = 125/664 (18%), Positives = 278/664 (41%), Gaps = 42/664 (6%) Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61 L++ + +D +H+ F+ EL +++ +E +E++ Q +E + + V +L Sbjct: 765 LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRD-SPDVTHRL 823 Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM---ESQLQDVDPGGDL 118 +R+ + ++ + + ++L EA L F E D L M E L +++ L Sbjct: 824 QALRELYQQVVAQADLRQQRLQEAL---DLYTVFGETDACELWMGEKEKWLAEMEMPDTL 880 Query: 119 ATVNSQLKKLQSMESQVEEWYREVG--ELQAQTAALPLEPASKELVGERQNAVGERLVRL 176 + + ++ +++ ++ L A + P S+E V + Q+ + R Sbjct: 881 EDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE-VKQYQDHLNTRWQAF 939 Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT-ERGNGLQAVQQHIKKNQG 235 + ERR + ++ +H D ++ W+ ++ + T + G L + +K G Sbjct: 940 QTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999 Query: 236 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 295 L R++ A R++ + + L + E + + + L+ W GL+++ + ++ +L Sbjct: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGE 1059 Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 355 Q++ + D+ + +AWL + + SED + QLL++H ++ ++ +++S + Sbjct: 1060 VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQR 1119 Query: 356 LSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVS 413 + +++ G D E + +R +D + AL + E R L Q + + Sbjct: 1120 VKESGEKVIQ-GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK 1178 Query: 414 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 473 + E ++ +E E E KF +F R+++ + ++L+ Sbjct: 1179 QAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSM-ENNRDKVLSPVDSGNKLVAE 1237 Query: 474 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 533 G+ + + E + + + E + LL + EL F + +EL I +K Sbjct: 1238 GNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK---- 1293 Query: 534 PRLTTPPEPRPSASSMQR----------TLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAG 583 LT+ A ++ L + E L+ + ++ +QL + Q Sbjct: 1294 -LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQF------ 1346 Query: 584 EHAEAIASREQEVLQG-WKELLSACEDARLHVSSTADA-LRFHSQVRDLLSWMDGIASQI 641 A+ S++ E L W EL + ++ H+S+ + LR + DL W+ + Q+ Sbjct: 1347 ---TALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQL 1402 Query: 642 GAAD 645 + D Sbjct: 1403 RSDD 1406 Score = 95.9 bits (237), Expect = 1e-19 Identities = 111/483 (22%), Positives = 206/483 (42%), Gaps = 28/483 (5%) Query: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229 G+R+ ++++ E +++ ++ +A DL L W+++ + + + N L VQQ Sbjct: 287 GKRVGKVIDHAIETEKMI---EKYSGLASDL---LTWIEQTITVLNSRKFANSLTGVQQQ 340 Query: 230 IKKNQGLRR-----EIQAHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGL 282 ++ R + Q G LE +L + + + G + + AW L Sbjct: 341 LQAFSTYRTVEKPPKFQEKG-NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESL 399 Query: 283 REAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQ 334 EA RR+ L ++EQ FD A E WL E + L+ ++ G D + Sbjct: 400 EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEA 459 Query: 335 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394 KKH +E YEE + L + L + + D ++I+ R+ + RL+ L+EL + Sbjct: 460 AKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQS 519 Query: 395 RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454 RR LE L +L + + W+ E + S E G+ V L +K ++ + Sbjct: 520 RRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAI 579 Query: 455 AGRERLAAVNQMVDELIE-CGHTAA--ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511 G +++ A+ + E G+ + + L + + EL + R L S+ Sbjct: 580 QG-DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKR 638 Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571 L KFF + E + I+EK + L + S +QR +AFE +L+ L + + Q+ Sbjct: 639 LWKFFWEMDEAESWIKEKEQIYSSLDYGKD-LTSVLILQRKHKAFEDELRGLDAHLEQIF 697 Query: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631 + A + H + I +R +EV W +L + ++ + +F DL Sbjct: 698 QEAHGMVARKQFGHPQ-IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756 Query: 632 SWM 634 +W+ Sbjct: 757 AWL 759 Score = 87.8 bits (216), Expect = 3e-17 Identities = 98/455 (21%), Positives = 196/455 (43%), Gaps = 14/455 (3%) Query: 17 KRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ 76 KR LR Q + + +N ++++ Q L+ + + G++ + +A L+ + Sbjct: 1624 KRHLRQQRAVEDYGRN---IKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680 Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136 + R+L QL + +L++ + E + G D V K + + Sbjct: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740 Query: 137 EWYRE-VGELQAQTAALPLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKEL 193 +E V + A L ++ E + E ++ + E LLE + R +LL AS +L Sbjct: 1741 AIGQERVDNVNAFIERL-IDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDL 1799 Query: 194 HQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253 H+ + + L + E+ + + G + + + RE+ G ++++ + Sbjct: 1800 HRYFYTGAEILGLIDEK-HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858 Query: 254 AGALASLRSPE-AEAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVA-EVE 310 A L + + E AEA++ +++ +AW L +A A RR Q++D A + +F +A ++ Sbjct: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFR--FFSMARDLL 1916 Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 +W+ + ++++ +D S L+K H + +E ++ + +LL+ H Sbjct: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976 Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430 SE+I + QV + E E R L + Q SR S E W+ +E S + Sbjct: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036 Query: 431 LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 465 G + V L ++ F T + ER AA+ + Sbjct: 2037 FGHTVDSVEKLIKRHEAFEKSTA-SWAERFAALEK 2070 Score = 37.7 bits (86), Expect = 0.035 Identities = 25/128 (19%), Positives = 52/128 (40%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81 HQ AE+ + G+ L+Q + + + +R+KL ++ E+ +A+ + Sbjct: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWER 2004 Query: 82 LFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYRE 141 L + Q + + + L+ E L D G + +V +K+ ++ E W Sbjct: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064 Query: 142 VGELQAQT 149 L+ T Sbjct: 2065 FAALEKPT 2072 Score = 35.8 bits (81), Expect = 0.13 Identities = 51/279 (18%), Positives = 106/279 (37%), Gaps = 13/279 (4%) Query: 379 SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 438 S++ L V K +G+ A+E + + + S S+L WI + V S + V Sbjct: 278 SKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGV 337 Query: 439 SVLQEKFSEFAS---ETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK--DGLNEAWA 493 + FS + + + L + + + + T + K +N AW Sbjct: 338 QQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWE 397 Query: 494 ELLEL-----MGTRAQLLAASR--ELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSA 546 L E + R +L+ + +L + F ++ + +RL + Sbjct: 398 SLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAV 457 Query: 547 SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA 606 + ++ A E D +VR L++ A +L + + I +R+ +L+ W L Sbjct: 458 EAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-KRITARKDNILRLWSYLQEL 516 Query: 607 CEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645 + R + +T + + + WMD I + + +A+ Sbjct: 517 LQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAE 555 >gi|67782319 spectrin beta isoform b [Homo sapiens] Length = 2137 Score = 577 bits (1488), Expect = e-165 Identities = 304/653 (46%), Positives = 424/653 (64%), Gaps = 8/653 (1%) Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 +L ++D + ++ LH +WL+HQAF+AELA ++ WLE I+ EG+QLM EKP+ A V +K Sbjct: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQK 1353 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 L + + W EL++TT+ K + L A +D +Q+ A+L+K + ME QL+ DPG DL + Sbjct: 1354 LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTS 1413 Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180 VN L KL+ +E QV E+GEL AQ P+ E G+ ++ +R + LLEPL Sbjct: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQV------PSMGEEGGDADLSIEKRFLDLLEPL 1467 Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 R++ L +S+ Q++ DL+DE WV+ERLPLA + G LQ VQ +KKNQ L+ EI Sbjct: 1468 GRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEI 1527 Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 H PR+E+VL+R L + + + L LQS+W LREAA R Q L A + + Sbjct: 1528 LGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQ 1587 Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 QYY D E EAW+GEQEL ++S++ KDE+ + +LK+HL+ ++ VE+Y +I QL+ + Sbjct: 1588 QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA 1647 Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420 + LL GHP+ EQI R Q QVD+ Y LK++ EER+ LE Y L+QL R+ +LE WI+ Sbjct: 1648 QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWIS 1707 Query: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480 EKE+VA SPE+GQDF+HV++L++KF +FA ETG G+ER+ VN ++ LI+ GH+ AAT Sbjct: 1708 EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT 1767 Query: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540 +AEWKDGLNE WA+LLEL+ TR QLLAAS +LH++F E+ G I+EK R LP Sbjct: 1768 IAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE--DVG 1825 Query: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600 +A S R AFE +L LL QV+Q Q+ A +L+T YAGE AEAI ++EQEV W Sbjct: 1826 LDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAW 1885 Query: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653 + LL AC R + TAD RF S RDLLSWM+ I QI ++PR SS+ Sbjct: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSV 1938 Score = 161 bits (407), Expect = 2e-39 Identities = 131/650 (20%), Positives = 274/650 (42%), Gaps = 7/650 (1%) Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61 L+A+D D + +H+A + A +E + +E Q+L +E + + Sbjct: 444 LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503 Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121 I + W+ L+ Q++ ++L +L Q + +++ L + G L V Sbjct: 504 DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563 Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALP----LEPASKELVGERQNAVGERLVRLL 177 L+K + ME+ + +V + A T +P +++ +R + + + L Sbjct: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623 Query: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237 R+ L SK L + ++D+ +W++E+ + + G L +V +K++ Sbjct: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683 Query: 238 REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297 E++ LE++ + A + + + + ++++ + W L++ A ++ L A Sbjct: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAE 743 Query: 298 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357 Q+ D +++AWL + L+ ED G+DE +T L KKH + +E + L Sbjct: 744 NFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLE 803 Query: 358 RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEH 417 +Q + E DS ++ R + LY + + R+ L++ LY + + E Sbjct: 804 QQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACEL 862 Query: 418 WIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTA 477 W+ EKE E+ E + V+Q +F E ++ VN + L+E GH Sbjct: 863 WMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL-MTQIDGVNLAANSLVESGHPR 921 Query: 478 AATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537 + + +++D LN W L+ R + + ++ +H + D E I +K + + Sbjct: 922 SREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK 981 Query: 538 TPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL 597 ++QR L E D+ + ++V L+ + QL + E E I R++ + Sbjct: 982 DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLE 1040 Query: 598 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647 + W+ L + + + + F + D +W+ + + D P Sbjct: 1041 ELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMP 1090 Score = 105 bits (261), Expect = 2e-22 Identities = 125/664 (18%), Positives = 278/664 (41%), Gaps = 42/664 (6%) Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61 L++ + +D +H+ F+ EL +++ +E +E++ Q +E + + V +L Sbjct: 765 LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRD-SPDVTHRL 823 Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM---ESQLQDVDPGGDL 118 +R+ + ++ + + ++L EA L F E D L M E L +++ L Sbjct: 824 QALRELYQQVVAQADLRQQRLQEAL---DLYTVFGETDACELWMGEKEKWLAEMEMPDTL 880 Query: 119 ATVNSQLKKLQSMESQVEEWYREVG--ELQAQTAALPLEPASKELVGERQNAVGERLVRL 176 + + ++ +++ ++ L A + P S+E V + Q+ + R Sbjct: 881 EDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE-VKQYQDHLNTRWQAF 939 Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT-ERGNGLQAVQQHIKKNQG 235 + ERR + ++ +H D ++ W+ ++ + T + G L + +K G Sbjct: 940 QTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999 Query: 236 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 295 L R++ A R++ + + L + E + + + L+ W GL+++ + ++ +L Sbjct: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGE 1059 Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 355 Q++ + D+ + +AWL + + SED + QLL++H ++ ++ +++S + Sbjct: 1060 VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQR 1119 Query: 356 LSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVS 413 + +++ G D E + +R +D + AL + E R L Q + + Sbjct: 1120 VKESGEKVIQ-GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK 1178 Query: 414 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 473 + E ++ +E E E KF +F R+++ + ++L+ Sbjct: 1179 QAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSM-ENNRDKVLSPVDSGNKLVAE 1237 Query: 474 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 533 G+ + + E + + + E + LL + EL F + +EL I +K Sbjct: 1238 GNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK---- 1293 Query: 534 PRLTTPPEPRPSASSMQR----------TLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAG 583 LT+ A ++ L + E L+ + ++ +QL + Q Sbjct: 1294 -LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQF------ 1346 Query: 584 EHAEAIASREQEVLQG-WKELLSACEDARLHVSSTADA-LRFHSQVRDLLSWMDGIASQI 641 A+ S++ E L W EL + ++ H+S+ + LR + DL W+ + Q+ Sbjct: 1347 ---TALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQL 1402 Query: 642 GAAD 645 + D Sbjct: 1403 RSDD 1406 Score = 95.9 bits (237), Expect = 1e-19 Identities = 111/483 (22%), Positives = 206/483 (42%), Gaps = 28/483 (5%) Query: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229 G+R+ ++++ E +++ ++ +A DL L W+++ + + + N L VQQ Sbjct: 287 GKRVGKVIDHAIETEKMI---EKYSGLASDL---LTWIEQTITVLNSRKFANSLTGVQQQ 340 Query: 230 IKKNQGLRR-----EIQAHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGL 282 ++ R + Q G LE +L + + + G + + AW L Sbjct: 341 LQAFSTYRTVEKPPKFQEKG-NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESL 399 Query: 283 REAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQ 334 EA RR+ L ++EQ FD A E WL E + L+ ++ G D + Sbjct: 400 EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEA 459 Query: 335 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394 KKH +E YEE + L + L + + D ++I+ R+ + RL+ L+EL + Sbjct: 460 AKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQS 519 Query: 395 RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454 RR LE L +L + + W+ E + S E G+ V L +K ++ + Sbjct: 520 RRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAI 579 Query: 455 AGRERLAAVNQMVDELIE-CGHTAA--ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511 G +++ A+ + E G+ + + L + + EL + R L S+ Sbjct: 580 QG-DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKR 638 Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571 L KFF + E + I+EK + L + S +QR +AFE +L+ L + + Q+ Sbjct: 639 LWKFFWEMDEAESWIKEKEQIYSSLDYGKD-LTSVLILQRKHKAFEDELRGLDAHLEQIF 697 Query: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631 + A + H + I +R +EV W +L + ++ + +F DL Sbjct: 698 QEAHGMVARKQFGHPQ-IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756 Query: 632 SWM 634 +W+ Sbjct: 757 AWL 759 Score = 87.8 bits (216), Expect = 3e-17 Identities = 98/455 (21%), Positives = 196/455 (43%), Gaps = 14/455 (3%) Query: 17 KRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ 76 KR LR Q + + +N ++++ Q L+ + + G++ + +A L+ + Sbjct: 1624 KRHLRQQRAVEDYGRN---IKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680 Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136 + R+L QL + +L++ + E + G D V K + + Sbjct: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740 Query: 137 EWYRE-VGELQAQTAALPLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKEL 193 +E V + A L ++ E + E ++ + E LLE + R +LL AS +L Sbjct: 1741 AIGQERVDNVNAFIERL-IDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDL 1799 Query: 194 HQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253 H+ + + L + E+ + + G + + + RE+ G ++++ + Sbjct: 1800 HRYFYTGAEILGLIDEK-HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858 Query: 254 AGALASLRSPE-AEAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVA-EVE 310 A L + + E AEA++ +++ +AW L +A A RR Q++D A + +F +A ++ Sbjct: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFR--FFSMARDLL 1916 Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 +W+ + ++++ +D S L+K H + +E ++ + +LL+ H Sbjct: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976 Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430 SE+I + QV + E E R L + Q SR S E W+ +E S + Sbjct: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036 Query: 431 LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 465 G + V L ++ F T + ER AA+ + Sbjct: 2037 FGHTVDSVEKLIKRHEAFEKSTA-SWAERFAALEK 2070 Score = 37.7 bits (86), Expect = 0.035 Identities = 25/128 (19%), Positives = 52/128 (40%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81 HQ AE+ + G+ L+Q + + + +R+KL ++ E+ +A+ + Sbjct: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWER 2004 Query: 82 LFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYRE 141 L + Q + + + L+ E L D G + +V +K+ ++ E W Sbjct: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064 Query: 142 VGELQAQT 149 L+ T Sbjct: 2065 FAALEKPT 2072 Score = 35.8 bits (81), Expect = 0.13 Identities = 51/279 (18%), Positives = 106/279 (37%), Gaps = 13/279 (4%) Query: 379 SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 438 S++ L V K +G+ A+E + + + S S+L WI + V S + V Sbjct: 278 SKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGV 337 Query: 439 SVLQEKFSEFAS---ETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK--DGLNEAWA 493 + FS + + + L + + + + T + K +N AW Sbjct: 338 QQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWE 397 Query: 494 ELLEL-----MGTRAQLLAASR--ELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSA 546 L E + R +L+ + +L + F ++ + +RL + Sbjct: 398 SLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAV 457 Query: 547 SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA 606 + ++ A E D +VR L++ A +L + + I +R+ +L+ W L Sbjct: 458 EAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-KRITARKDNILRLWSYLQEL 516 Query: 607 CEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645 + R + +T + + + WMD I + + +A+ Sbjct: 517 LQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAE 555 >gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] Length = 2390 Score = 531 bits (1367), Expect = e-150 Identities = 290/653 (44%), Positives = 414/653 (63%), Gaps = 10/653 (1%) Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 ML A+D + ++ LH +W +HQAFMAELA NK+WL+K+++EG++L EKPEL A V +K Sbjct: 1298 MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK 1357 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 L ++ + W ELE+TTQAKAR LF+A++A+ QS L+ L +++QL D G DL + Sbjct: 1358 LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTS 1417 Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180 VN LKK Q +E ++ +EV +QAQ AL E V AV E+ L +P+ Sbjct: 1418 VNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPM 1477 Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 +ER R L AS+E HQ D++DE+ WV ERLP+A E G L +VQ +KKNQ L++EI Sbjct: 1478 RERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEI 1537 Query: 241 QAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV 299 Q H PR+ ++ ER AL A+ PE L +LQ W L E R + L+ A + Sbjct: 1538 QGHEPRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRGKRLEDALRA 1590 Query: 300 EQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ 359 +Q+Y D AE EAW+GEQEL MM ++K KDE S +KKH LEQ + +Y ++I QL+ Sbjct: 1591 QQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAAS 1650 Query: 360 CRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419 + +++ HP+S +IS RQ+QVD+LY LKEL ERR L++ L QL R++ +LE WI Sbjct: 1651 SQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710 Query: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479 E+EVVA S ELGQD+EHV++L++KF EF+ +T G+ER+ + N + + LI GH A A Sbjct: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770 Query: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539 T+AEWKD LNEAWA+LLEL+ TR Q+LAA+ EL +F AR+ +++ K+++LP T Sbjct: 1771 TVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGT-- 1828 Query: 540 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599 +A ++QR A+EHD+Q L QV+Q+Q+ +L+ YAG+ AE I Q V + Sbjct: 1829 GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEA 1888 Query: 600 WKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSS 652 W +L + R + T D RF VR+L+ WMD + Q+ A ++PR SS Sbjct: 1889 WAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSS 1941 Score = 151 bits (381), Expect = 2e-36 Identities = 136/593 (22%), Positives = 254/593 (42%), Gaps = 29/593 (4%) Query: 61 LGEIRQCWAELESTTQAKARQL-FEASKADQLVQSFAELDKKLLHMESQLQDVDP----- 114 + +I + W LE + L E + ++L Q A D+K E+ L + Sbjct: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451 Query: 115 --GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK-ELVGERQNAVGE 171 G +LA V + ++K +++E+ + + V + A A L E + + RQ+ V Sbjct: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511 Query: 172 RLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIK 231 L + + RR LL + EL +V DL + W++E + G L V+ ++ Sbjct: 512 LWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQ 571 Query: 232 KNQGLRREIQAHGPRLEEVLERAGALAS----LRSPEAEAVRRGLEQLQSAWAGLREAAE 287 ++ + +I R+ V A + R + + V + +L+ ++ L E A Sbjct: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631 Query: 288 RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVE 347 R+ L+ + ++ ++ ++V E EAW+ EQ+ L+ S D G+D L+LL KH L + Sbjct: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691 Query: 348 NYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQ 407 + Q + L+ GHP + Q S R +++ + L+ L EER L Q LYQ Sbjct: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751 Query: 408 LSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467 +++E W+ + + SPELG D E ++ + A E + + + Sbjct: 752 FQADANDMEAWLVDALRLVSSPELGHD--------EFSTQALARQHRALEEEIRSHRPTL 803 Query: 468 DELIECGHTAAATMAEWKD------GLNEAWAELLELMGTRAQLLAASRELHKFFSDARE 521 D L E T++ + L + EL G RA+ L A+ L+ S+A Sbjct: 804 DALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGA 863 Query: 522 LQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVY 581 +EEK + L L PE +Q+ E ++ L +Q+ + + A QL Sbjct: 864 CGLWVEEKEQWLNGLAL-PERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKAN 922 Query: 582 AGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWM 634 + I + ++++ W++ + + ++S +H + + +WM Sbjct: 923 P-PGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWM 974 Score = 125 bits (315), Expect = 1e-28 Identities = 132/623 (21%), Positives = 248/623 (39%), Gaps = 17/623 (2%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 +H A E++ L+ +GQQL+ E A+ + E++ W LE+ + +A+ Sbjct: 682 KHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQ 741 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +L +A+ Q +++ L+ + + G D + + ++ +++E ++ Sbjct: 742 RLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRP 801 Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL 200 + L+ Q AALP + V R + L ER R L A+ L+ + + Sbjct: 802 TLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEA 861 Query: 201 DDELAWVQER---LPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 257 WV+E+ L ER L+ VQQ + L E+ ++ V + A L Sbjct: 862 GACGLWVEEKEQWLNGLALPERLEDLEVVQQRF---ETLEPEMNTLAAQITAVNDIAEQL 918 Query: 258 ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQ- 316 P + + EQL W R A+ ++ L +A ++ Y+ + E +AW+ E+ Sbjct: 919 LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKT 978 Query: 317 ELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP-DSEQIS 375 +++ ++ G D L L +K E+ +E + +L+R+ A L GHP + I+ Sbjct: 979 KVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANA-LAAGHPAQAVAIN 1037 Query: 376 RRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDF 435 R +V + L+ R +L + L R + + + W+ + S E Sbjct: 1038 ARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATL 1097 Query: 436 EHVSVLQEKFSEFASETGMAGRE--RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWA 493 L + + E A E RL A+ + V + + + + L W Sbjct: 1098 PEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR--DQADPQCLFLRQRLEALGTGWE 1155 Query: 494 ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL 553 EL + +R LA + F DAR+ +G + + L T P +A + + L Sbjct: 1156 ELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSH-TEMPGTLQAADAAIKKL 1214 Query: 554 RAFEHDLQLLVSQVRQLQEGAAQLRTVYAGE-HAEAIASREQEVLQGWKELLSACEDARL 612 F + ++ L E QL V G HA+ I + + + K+ A + Sbjct: 1215 EDFMSTMDANGERIHGLLEAGRQL--VSEGNIHADKIREKADSIERRHKKNQDAAQQFLG 1272 Query: 613 HVSSTADALRFHSQVRDLLSWMD 635 + + F +L W+D Sbjct: 1273 RLRDNREQQHFLQDCHELKLWID 1295 Score = 108 bits (269), Expect = 2e-23 Identities = 135/640 (21%), Positives = 269/640 (42%), Gaps = 32/640 (5%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQL---MQEKPELAASVRKKLGEIRQCWAELESTTQA 77 +H+A E+ ++ L+ + + L + PE V+ ++ + + + EL++ Sbjct: 788 QHRALEEEIRSHRPTLDALREQAAALPPTLSRTPE----VQGRVPTLERHYEELQARAGE 843 Query: 78 KARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEE 137 +AR L EA+ A L +E L +E + Q ++ + +L+ L+ ++ + E Sbjct: 844 RARAL-EAALA--LYTMLSEAGACGLWVEEKEQWLNG----LALPERLEDLEVVQQRFET 896 Query: 138 WYREVGELQAQTAA--------LPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLA 189 E+ L AQ A L P K+ + Q + R + ++ L + Sbjct: 897 LEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTS 956 Query: 190 SKELHQVAHDLDDELAWVQERLPLAMQTER-GNGLQAVQQHIKKNQGLRREIQAHGPRLE 248 + + + + AW++E+ + T+ GN L V +K G R+++A R+ Sbjct: 957 ALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVG 1016 Query: 249 EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 308 E+ A ALA+ +A A+ L ++Q+ W LR RR++ L A +++ + + + Sbjct: 1017 ELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDD 1076 Query: 309 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 368 +AWLG + + SE+ LL +H L VE + ++L R + Sbjct: 1077 FQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL-RALGEEVTRDQ 1135 Query: 369 PDSEQISRRQSQVDRLYVALKELG---EERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425 D + + RQ +++ L +ELG E R+ L Q + R + E ++ +E V Sbjct: 1136 ADPQCLFLRQ-RLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYV 1194 Query: 426 AGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485 E+ + +K +F S T A ER+ + + +L+ G+ A + E Sbjct: 1195 LSHTEMPGTLQAADAAIKKLEDFMS-TMDANGERIHGLLEAGRQLVSEGNIHADKIREKA 1253 Query: 486 DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS 545 D + + + L +RE F D EL+ I+EK ++ E R Sbjct: 1254 DSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSY-DEARNL 1312 Query: 546 ASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLS 605 + Q+ +AF +L + ++ + +L T+ E ++ + +++ + W EL + Sbjct: 1313 HTKWQKH-QAFMAELAANKDWLDKVDKEGREL-TLEKPELKALVSEKLRDLHRRWDELET 1370 Query: 606 ACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645 + + A F L SW++ + +Q+ + D Sbjct: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDD 1410 Score = 104 bits (259), Expect = 3e-22 Identities = 144/648 (22%), Positives = 251/648 (38%), Gaps = 73/648 (11%) Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93 E + K+E+ + L ELAA+ R +L E R+ W R L+E +A+ V+ Sbjct: 614 ERVAKLEQSYEALC----ELAAARRARLEESRRLW-----------RFLWEVGEAEAWVR 658 Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 153 L L D G DL L K ++ GE+ + L Sbjct: 659 EQQHL----------LASADTGRDLTGALRLLNKHTALR----------GEMSGRLGPLK 698 Query: 154 LE-PASKELVGERQNAVGERLVRL---------LEPL-QERRRLLLASKELHQVAHDLDD 202 L ++LV E + R LE L +ER + L + L+Q D +D Sbjct: 699 LTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADAND 758 Query: 203 ELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL-- 260 AW+ + L L E G+ + Q ++++ L EI++H P L+ + E+A AL Sbjct: 759 MEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLS 818 Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320 R+PE V+ + L+ + L+ A R + L+AA + + W+ E+E + Sbjct: 819 RTPE---VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWL 875 Query: 321 MSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380 + + + ++ LE + I ++ LL+ P ++I Q Q Sbjct: 876 NGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQ 935 Query: 381 VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK-EVVAGSPELGQDFEHVS 439 ++ + + L + ++ AL + + +E + W+ EK +V+ + LG D V Sbjct: 936 LNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVL 995 Query: 440 VLQEKFSEFASETGMAGRER-LAAVNQMVDEL------IECGHTAAATMAEWK-DGLNEA 491 LQ K +AG ER L A+ V EL + GH A A + + Sbjct: 996 ALQRK---------LAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTG 1046 Query: 492 WAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQR 551 W +L M R + L +R L F + Q + + + P P A ++ Sbjct: 1047 WEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS-EEGPATLPEAEALLA 1105 Query: 552 TLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDAR 611 A +++ S+ +L+ ++ A + R + + GW+EL E + Sbjct: 1106 QHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQ 1165 Query: 612 LHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGLPAS 659 A A F +RD ++SQ P +L A+ Sbjct: 1166 ---GRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAA 1210 Score = 104 bits (259), Expect = 3e-22 Identities = 124/563 (22%), Positives = 221/563 (39%), Gaps = 81/563 (14%) Query: 54 AASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD 113 AA+ +L E+++ W L + + ++L +A +A Q + AE + + E + + Sbjct: 1556 AAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQE 1615 Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTA-ALPLEPASKELVGERQNAVGER 172 D + +++KK Q +E + ++ + + +L A + + E + RQ V + Sbjct: 1616 KAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKL 1675 Query: 173 LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKK 232 L E ERR L L Q+ +LDD W+QER +A E G + V K Sbjct: 1676 YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDK 1735 Query: 233 NQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGL----EQLQSAWAGLREAAER 288 + R+ G +E ++ A ALA+ A R + + L AWA L E + Sbjct: 1736 FREFSRDTSTIG---QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDT 1792 Query: 289 RQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 348 R QVL AA++++++ + A + ++ + + G+D + L ++H Sbjct: 1793 RGQVLAAAYELQRFLHGARQALARVQHKQQ-QLPDGTGRDLNAAEALQRRHCA------- 1844 Query: 349 YEESIAQLSRQCRALLEMGH--------PDSEQISRRQSQVDRLYVALKELGEERRVALE 400 YE I LS Q + + + GH +E+I R V + L+ RR L Sbjct: 1845 YEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLL 1904 Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460 ++ + V EL W+ E + + E +D ++ + +E A +R Sbjct: 1905 DTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIE-ARADRF 1963 Query: 461 AAVNQMVDELIECGHTAAATMAE---------------WKD------------------G 487 ++ M EL+ H AA ++E W++ G Sbjct: 1964 SSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAG 2023 Query: 488 LNEAWAELLELMGTRAQLLAASREL------HKFFSDA-----------------RELQG 524 + EAW E + A+L E+ H+ F + E + Sbjct: 2024 MAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREK 2083 Query: 525 QIEEKRRRLPRLTTPPEPRPSAS 547 + + KR R PP P P+AS Sbjct: 2084 ERKRKREEEERRKQPPAPEPTAS 2106 Score = 99.0 bits (245), Expect = 1e-20 Identities = 94/449 (20%), Positives = 192/449 (42%), Gaps = 5/449 (1%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 +HQ LA + + ++ Q ++ + + + + ++ + +A L+ + Sbjct: 1629 KHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRE 1688 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +L E + QL + +L++ + E + G D V K + + Sbjct: 1689 RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQ 1748 Query: 141 E-VGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH 198 E V A L A++ V E ++++ E LLE L R ++L A+ EL + H Sbjct: 1749 ERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLH 1808 Query: 199 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258 LA VQ + + G L A + +++ +IQA P++++V + L Sbjct: 1809 GARQALARVQHKQQ-QLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQ 1867 Query: 259 -SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQE 317 + +AE + R ++ + AWA L+ ++ R+Q+L +++ V E+ W+ E Sbjct: 1868 KAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVN 1927 Query: 318 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRR 377 L M ++++ +D S ++K ++ +E + + + LL H +E+IS + Sbjct: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEK 1987 Query: 378 QSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEH 437 SQ+ E +E+ L+ + R E W+ +E + S ELG + Sbjct: 1988 LSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDE 2047 Query: 438 VSVLQEKFSEFASETGMAGRERLAAVNQM 466 V L ++ F ++ +A ER A+ ++ Sbjct: 2048 VESLIKRHEAF-QKSAVAWEERFCALEKL 2075 >gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] Length = 3639 Score = 269 bits (687), Expect = 7e-72 Identities = 184/643 (28%), Positives = 311/643 (48%), Gaps = 11/643 (1%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 RH+A +EL + +E +++ G++L+ +P ++ +L +R W L + Sbjct: 1319 RHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +L +A + +QL++ + ++L +E LQ + G DL + K+ Q +ES+ Sbjct: 1379 ELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAA 1438 Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL 200 ++ L + + PA E E Q + RL L L R L AS ELHQ H Sbjct: 1439 KMAALASMAHGMAASPAILE---ETQKHL-RRLELLQGHLAIRGLQLQASVELHQFCHLS 1494 Query: 201 DDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL 260 + EL+WV E +P T L Q +K++ L+ E++AH +++ VL +LA+ Sbjct: 1495 NMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAAS 1554 Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320 P+A+ + ++L+ WA L A E R Q L A +QY+ DV+E+E W+ E+ L+ Sbjct: 1555 GHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLV 1614 Query: 321 MSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380 S D G+DE +TL+L+ KH L++ + Y S+ +L + + L P+ +++ Q + Sbjct: 1615 SSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVV--QER 1672 Query: 381 VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA-EKEVVAGSPELGQDFEHVS 439 + AL+EL R LE L++ R+ +L+ W+A +K+ G LG+D EH Sbjct: 1673 LREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHAL 1732 Query: 440 VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELM 499 L KF++F + M G +R+AA + + L+E GH+A + + + L AW+EL EL Sbjct: 1733 HLCTKFAKFQHQVEM-GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT 1791 Query: 500 GTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHD 559 R L + + D E+ Q++EK LP + R+ + E + Sbjct: 1792 QARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP--NNVARDLCGLEAQLRSHQGLERE 1849 Query: 560 LQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTAD 619 L Q+++L E A +++ + G A A+ R+Q V Q W L E R + Sbjct: 1850 LVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARL 1909 Query: 620 ALRFHSQVRDLLSWMDGIASQIGAADKPRCPSS-LLGLPASPW 661 RF + VRD SW + + + + PSS L L A W Sbjct: 1910 LARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQW 1952 Score = 248 bits (632), Expect = 2e-65 Identities = 177/624 (28%), Positives = 302/624 (48%), Gaps = 7/624 (1%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70 D L + + Q F AEL + ++++REGQ+L+Q + +++++L E+ W E Sbjct: 2677 DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGE 2736 Query: 71 LESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQS 130 L+ +Q K +L +A +A +L +S EL+ L +E +L+ G L V L + Sbjct: 2737 LQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRE 2796 Query: 131 MESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLLA 189 +E+ V++ R+ L Q A E + V E+ + +R L EPLQERR L A Sbjct: 2797 LEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEA 2856 Query: 190 SKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEE 249 L + D D+E+AWVQE+LPLA + G L AV+ +++Q L E+ +H Sbjct: 2857 RSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRV 2916 Query: 250 VLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 VL L A V ++QL+ A A LR A RR+ +L A + +Q+ ++ E Sbjct: 2917 VLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEA 2976 Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369 +WL E+ ++ SED G ++T LL++ ++ +E + I +L + L +P Sbjct: 2977 GSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNP 3036 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429 +S ++ + V + L E R L++Q L+QL R+ L+ W+ K A S Sbjct: 3037 ESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQ 3096 Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489 + GQD E V VL+EKF F E G+ ++ A+ ++ L + + + Sbjct: 3097 DYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIE 3156 Query: 490 EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549 AW L + + R + LAA+ E+H F A ELQG+++EK L + S ++ Sbjct: 3157 AAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEK-TALMKGEDGGHSLSSVRTL 3215 Query: 550 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609 Q+ R E +L+ + +V +LQ A +L G+ A +V + W L + ++ Sbjct: 3216 QQQHRRLERELEAMEKEVARLQTEACRL-----GQLHPAAPGGLAKVQEAWATLQAKAQE 3270 Query: 610 ARLHVSSTADALRFHSQVRDLLSW 633 ++ A F + ++LL+W Sbjct: 3271 RGQWLAQAAQGHAFLGRCQELLAW 3294 Score = 150 bits (379), Expect = 4e-36 Identities = 138/638 (21%), Positives = 282/638 (44%), Gaps = 22/638 (3%) Query: 17 KRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ 76 K L+HQAF AE+ ++E + + ++G+ L+ + A V ++L +R+ W +L Sbjct: 2151 KPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMA 2210 Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM----- 131 + ++L + + +Q + + E ++ D G DL ++L+ Sbjct: 2211 LRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSA 2270 Query: 132 -ESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLAS 190 ++ + R + +L Q +P +++ +R++ + R L ++ L + Sbjct: 2271 GDTVGDACIRSISDLSLQLK--NRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGA 2328 Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 E+H ++ +LD+ +QE+ L + G L++VQ+ ++K++ L RE+ ++E + Sbjct: 2329 LEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388 Query: 251 LERAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 G L RSPE A +R +++ +W LR A++R++ LDA Q ++ + E+ Sbjct: 2389 EREVGRLCQ-RSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL 2447 Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369 M + + ++L++H + + ++++ +SI+ + LL GHP Sbjct: 2448 LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHP 2507 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429 S I + + +++ +L+ +E ++ L+Q L V ++E W+ KE S Sbjct: 2508 FSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE 2567 Query: 430 ELGQDFEHVSVL--QEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG 487 L + L + K E+ E AG +++A+ L + GH A + Sbjct: 2568 GLWDPLAPMEPLLWKHKMLEWDLEV-QAG--KISALEATARGLHQGGHPEAQSALGRCQA 2624 Query: 488 LNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSAS 547 + L GTR L R+L F D++E+ + EK L E + Sbjct: 2625 MLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK-----NLVALEEGLLDTA 2679 Query: 548 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEH--AEAIASREQEVLQGWKELLS 605 + L+ ++ L + + Q QE + + + G H +EAI R +E+ W EL Sbjct: 2680 MLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQD 2739 Query: 606 ACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGA 643 + + +ALR + +L +W++ I ++ A Sbjct: 2740 NSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRA 2777 Score = 130 bits (326), Expect = 5e-30 Identities = 147/636 (23%), Positives = 268/636 (42%), Gaps = 25/636 (3%) Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 69 +D + + +H+ E+ + +E +ERE +L Q PE A +R + E+ + W Sbjct: 2359 KDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWW 2418 Query: 70 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 129 +L S Q + L +A +L EL + +Q+ L++ Q Sbjct: 2419 QLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQ 2478 Query: 130 SMESQVEEW------YREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183 +++++ W R G+ Q TA P ++++ + + L L QE Sbjct: 2479 ECKAELDSWTDSISLARSTGQ-QLLTAGHPFSSDIRQVLA----GLEQELSSLEGAWQEH 2533 Query: 184 RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243 + L + EL ++ W+ + + L ++ + K++ L +++ Sbjct: 2534 QLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQ 2593 Query: 244 GPRLEEVLERAGALASLRSPEAE-AVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQY 302 ++ + A L PEA+ A+ R L A R+A RR + L+ Q++ + Sbjct: 2594 AGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAF 2652 Query: 303 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLK-KHLQLEQGVENYEESIAQLSRQCR 361 D EV AWL E+ L+ + E QL K ++ Q E +++ +L R+ + Sbjct: 2653 LQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQ--ELQREGQ 2710 Query: 362 ALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAE 421 LL+ GHP SE I R ++ L+ L++ +++ L++ +L R + ELE+W+ Sbjct: 2711 RLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770 Query: 422 KEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481 EV +P +GQ V L E + R+ A + Q + GH A + Sbjct: 2771 IEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQ-AQAFVREGHCLAQDV 2829 Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541 E L + + L E + R L A L KFF DA E ++EK LP L + Sbjct: 2830 EEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEK---LP-LAAAQD 2885 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEG--AAQLRTVYAGEH-AEAIASREQEVLQ 598 S S++ R L+ +L+ +S L + V AG A +A+R Q++ + Sbjct: 2886 YGQSLSAV-RHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEK 2944 Query: 599 GWKELLSACEDARLHVSSTADALRFHSQVRDLLSWM 634 L + RL + +A +F +++ + SW+ Sbjct: 2945 AMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWL 2980 Score = 125 bits (314), Expect = 1e-28 Identities = 142/647 (21%), Positives = 264/647 (40%), Gaps = 31/647 (4%) Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIR 65 D ED + +H+ F L+ E + G++L+Q + A +VR++L I+ Sbjct: 1199 DNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQ 1258 Query: 66 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 125 W L+ ++ + RQL + + + Q AEL + + + + +P G + L Sbjct: 1259 AQWTRLQGRSEQRRRQLLASLQLQEWKQDVAEL-MQWMEEKGLMAAHEPSGARRNILQTL 1317 Query: 126 KKLQSMESQVEEWYREVGEL-QAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERR 184 K+ ++ ES++ R V L Q L P +E + R + + L + ER Sbjct: 1318 KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERG 1377 Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244 L + + Q+ L D +++ +E G L++ Q+ K++Q L E + Sbjct: 1378 DELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLA 1437 Query: 245 PRLEEVLERAGALASLRS--PEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQY 302 ++ + A +A+ + E + R LE LQ A R L A+ ++ Q+ Sbjct: 1438 AKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLA-------IRGLQLQASVELHQF 1490 Query: 303 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRA 362 +W+ E + L +KH +L+ V+ ++ + ++ R+ Sbjct: 1491 CHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRS 1550 Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422 L GHP ++ I + +++ + L+ E R L+Q Q VSELE W+ EK Sbjct: 1551 LAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEK 1610 Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA--- 479 + S + G+D L K A +E LA ++EL + T Sbjct: 1611 RPLVSSRDYGRDEAATLRLINKH--------QALQEELAIYWSSMEELDQTAQTLTGPEV 1662 Query: 480 --TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537 ++ L E L EL TR + L + LH+F +A +LQG + +++ Sbjct: 1663 PEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGE 1722 Query: 538 TPPEPRPSASSMQRTLRAFEHDLQL---LVSQVRQLQEGAAQLRTVYAGEHAEAIASREQ 594 + E A + F+H +++ V+ R L E + R AG + R+Q Sbjct: 1723 SLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLE-RGHSAG---PMVRQRQQ 1778 Query: 595 EVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQI 641 ++ W EL + + T LR H + ++L+ + A+ + Sbjct: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL 1825 Score = 123 bits (309), Expect = 5e-28 Identities = 133/597 (22%), Positives = 248/597 (41%), Gaps = 40/597 (6%) Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79 L+++ F+ LA K ++ +QL Q P + ++++ E+ Q W +LE+ + KA Sbjct: 899 LKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKA 958 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNS-------------QLK 126 QL + + +Q +L + QL+ + PG T ++ ++ Sbjct: 959 VQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVH 1018 Query: 127 KLQSMESQVEE-WYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRR 185 LQS+ +VEE Y E LQ Q L + L+ + Q V +R R E Q R+ Sbjct: 1019 FLQSVVVKVEEPGYAESQPLQGQVETL------QGLLKQVQEQVAQRARRQAET-QARQS 1071 Query: 186 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 245 L S++L L W + E + + Q+ ++++Q L EI Sbjct: 1072 FLQESQQL----------LLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQE 1121 Query: 246 RLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFD 305 RL+++ ++ +A+L P+++ V L L L+ E+RQQ L +++++ + Sbjct: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGRE 1181 Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE 365 V A + + ++ G+D + L LL++H + + + L L++ Sbjct: 1182 VDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQ 1241 Query: 366 MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425 HP + + + + + L+ E+RR L L + + V+EL W+ EK ++ Sbjct: 1242 SQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLM 1301 Query: 426 AGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIE---CGHTAAATMA 482 A G + L K E A +A R + A+ Q+ EL+ CG T Sbjct: 1302 AAHEPSGARRNILQTL--KRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRL 1359 Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEP 542 + GL W L M R L + + + ++ + Q+E+ L T + Sbjct: 1360 Q---GLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDL 1416 Query: 543 RPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQG 599 R S+ +Q+ + E + + L +++ L A + A R E+LQG Sbjct: 1417 R-SSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQG 1472 Score = 122 bits (307), Expect = 8e-28 Identities = 145/688 (21%), Positives = 264/688 (38%), Gaps = 85/688 (12%) Query: 46 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM 105 L QE+ A V ++ E+ W L Q + +Q+ + L+Q +L + Sbjct: 458 LRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEEL 517 Query: 106 ESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLE-PASKELVGE 164 + + G LA V L++ +E+QV V L QTA L S E++ Sbjct: 518 QEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQA 577 Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224 + + + L+ ++ RR LL + + + + ++E AW++E G L Sbjct: 578 KARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLS 637 Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284 + ++K++ L E+ H +++ R L++ R P E +Q W L+ Sbjct: 638 QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQT 697 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344 R L A V QY+ D AE +WL E+ + G+D+ + LL++H++LE+ Sbjct: 698 RVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLER 757 Query: 345 GVENYEESIAQLSRQCRALLEMG---------------------------HP-------- 369 + + + +L Q RA HP Sbjct: 758 VLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKM 817 Query: 370 ----------DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419 D I + Q + + Y +L+ L + RR LE+ L+ EL+ W+ Sbjct: 818 ALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL 877 Query: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479 ++ V+ + + + V+Q K+ F + + G+ A V+ ++L + + Sbjct: 878 EKQTVLL--QRVQPQADTLEVMQLKYENFLTALAV-GKGLWAEVSSSAEQLRQRYPGNST 934 Query: 480 TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP 539 + ++ L++ W +L L +A LA S E+ F + Q Q+ + +L L P Sbjct: 935 QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEAL-QP 993 Query: 540 PEPRPSASSMQ------RTLRAFEHDLQLLVSQV----------------------RQLQ 571 + ++Q L H LQ +V +V +Q+Q Sbjct: 994 GSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQ 1053 Query: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA---CEDARLHVSSTADALRFHSQVR 628 E AQ A A +E + L W E + A ++ + V+S LR H + Sbjct: 1054 EQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLL 1113 Query: 629 DLLSWMDGIASQIGAADKPR----CPSS 652 + + Q+ A +P CP S Sbjct: 1114 EEIHLWQERLQQLDAQSQPMAALDCPDS 1141 Score = 111 bits (278), Expect = 2e-24 Identities = 124/582 (21%), Positives = 245/582 (42%), Gaps = 29/582 (4%) Query: 41 REGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDK 100 REG L Q+ E A + ++ +R+ E + +A++ L AD+ A + + Sbjct: 2820 REGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADE---EMAWVQE 2876 Query: 101 KLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA--S 158 KL +Q D G L+ V ++ Q++ES++ + + + T ++ + Sbjct: 2877 KLPLAAAQ----DYGQSLSAVRHLQEQHQNLESEMSS-HEALTRVVLGTGYKLVQAGHFA 2931 Query: 159 KELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTE 218 V R + + + L RR LL ++E Q +L + +W+ ER + + Sbjct: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991 Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSA 278 G+ +A Q +++ + +R+++A PR+E + + A L S ++PE+ V L+ ++ A Sbjct: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREA 3051 Query: 279 WAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKK 338 A L AE R L Q+ Q + ++AWL + S+D G+D + L +K Sbjct: 3052 HAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEK 3111 Query: 339 HLQLEQGVENYEESIAQLSRQCRALLEMGHPDS-EQISRRQSQVDRLYVALKELGEERRV 397 + V++ ++ R+ LE G P I ++S+++ + L + + R Sbjct: 3112 FDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171 Query: 398 ALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGR 457 L + ++ + +EL+ + EK + + G V LQ++ E + Sbjct: 3172 NLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEK 3231 Query: 458 ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517 E +A + L + A +A+ + EAWA L R Q LA + + H F Sbjct: 3232 E-VARLQTEACRLGQLHPAAPGGLAK----VQEAWATLQAKAQERGQWLAQAAQGHAFLG 3286 Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFE---HDLQLLVSQVRQLQEGA 574 +EL +E++ L + E + ++ L E +++ Q + L++ Sbjct: 3287 RCQELLAWAQERQ----ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342 Query: 575 AQL------RTVYAGEHAEAIASREQEVLQGWKELLSACEDA 610 QL + E + + R QE+ + W C ++ Sbjct: 3343 QQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAES 3384 Score = 100 bits (250), Expect = 3e-21 Identities = 147/628 (23%), Positives = 265/628 (42%), Gaps = 37/628 (5%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKA 79 +HQA ELA +E++++ Q L E PE V+++L E + EL +T + Sbjct: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---RD 1688 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEW 138 R+L + + ++ +L L + + + G D K + QVE Sbjct: 1689 RELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMG 1748 Query: 139 YREVGELQAQTAALPLEP--ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + V + +L LE ++ +V +RQ + L E Q R L ++ +V Sbjct: 1749 SQRVAACRLLAESL-LERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRV 1807 Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGA 256 DL + L VQE+ ++ L ++ ++ +QGL RE+ +L+E+LE AG Sbjct: 1808 HRDLLEVLTQVQEKAT-SLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866 Query: 257 LASL-RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 315 + L P+A AV++ + + AWA L+ E+R+ L+ A + ++ V + +W Sbjct: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926 Query: 316 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYE---ESIAQLSRQCRALLEMGHPD-- 370 + E+ ++ S L H L +E E + QL +Q ALL G P Sbjct: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQ--ALLAAGTPTKE 1984 Query: 371 -SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429 E++ Q Q D++Y ++ R+ EQQ L+ R+ LE +A +EV + Sbjct: 1985 VQEELRALQDQRDQVYQTWAR--KQERLQAEQQEQLF--LRECGRLEEILAAQEVSLKTS 2040 Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489 LG E V L K F + A ++ AA+ + + L + + L Sbjct: 2041 ALGSSVEEVEQLIRKHEVFL-KVLTAQDKKEAALRERLKTL------RRPRVRDRLPILL 2093 Query: 490 EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549 + + EL +R L AS + F A + + I+ ++L P + R + Sbjct: 2094 QRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL 2153 Query: 550 QRTLRAFEHDLQL---LVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA 606 + +AFE ++Q +++ V + E AGE ++ R Q + + W++L A Sbjct: 2154 LKH-QAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE----VSQRLQGLRKHWEDLRQA 2208 Query: 607 CEDARLHVSSTADALRFHSQVRDLLSWM 634 + + L F +V +W+ Sbjct: 2209 MALRGQELEDRRNFLEFLQRVDLAEAWI 2236 Score = 98.6 bits (244), Expect = 2e-20 Identities = 144/651 (22%), Positives = 254/651 (39%), Gaps = 91/651 (13%) Query: 61 LGEIRQCWAELE----STTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD--- 113 L E+ QCWA LE + +QA ++L + + + L + F K ES L+D + Sbjct: 358 LAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQH---KAALRESFLKDAEQVL 414 Query: 114 -----PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPL----EPASKELVGE 164 P LATV + +++L +E+ + + G QA + + S V Sbjct: 415 DQARAPPASLATVEAAVQRLGMLEAGI---LPQEGRFQALAEIADILRQEQYHSWADVAR 471 Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224 RQ V R RLL+ LQ +R+ + + + + +++ ++E A T G L Sbjct: 472 RQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLA 531 Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR---RGLEQLQSAWAG 281 V + ++++ L ++ AHG + + ++ L S E ++ R L QLQ + Sbjct: 532 EVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVA 591 Query: 282 LREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341 L A R+ +L+ Q ++ + E EAWL E + + G+D L+KH Sbjct: 592 LVRA---RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKA 648 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401 LE V ++ L R+ R L P R V + L+ R L+ Sbjct: 649 LEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQT 708 Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD--------FEHVSVLQEKFSEFASE-- 451 + Q +E W+ E+ GQD HV L+ FA+E Sbjct: 709 ALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVR-LERVLRAFAAELR 767 Query: 452 ------TGMAGRERLAAVNQMV----DELIECGHTAAA---------------------- 479 + R L VN + + L G + A Sbjct: 768 RLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDF 827 Query: 480 ---TMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 536 T+ + +D L++ + L L R L + L F S ELQ +E++ L R+ Sbjct: 828 DPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRV 887 Query: 537 TTPPEPRPSASSMQRTLRAFEHDLQLLV---SQVRQLQEGAAQLRTVYAGEHAEAIASRE 593 +P A +++ +E+ L L ++ A QLR Y G + I ++ Sbjct: 888 ------QPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ-IQRQQ 940 Query: 594 QEVLQGWKELLSACEDARLHVSSTADALRF-------HSQVRDLLSWMDGI 637 +E+ Q W +L + + + ++ + + F Q+RD+L ++ + Sbjct: 941 EELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEAL 991 Score = 98.2 bits (243), Expect = 2e-20 Identities = 101/450 (22%), Positives = 191/450 (42%), Gaps = 8/450 (1%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 R +A +L +E++++ L K + V +L +R+ AEL +A+ Sbjct: 3005 RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGH 3064 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 L E + QL + LD L + + D G DL V +K + +V+ + Sbjct: 3065 GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQ 3124 Query: 141 -EVGELQAQTAALPL-EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH 198 +V L+ L P + +++ + RL + ++ R L A+ E+H Sbjct: 3125 AKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184 Query: 199 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258 + +QE+ L + G+ L +V+ ++++ L RE++A + + A L Sbjct: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLG 3244 Query: 259 SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQEL 318 L A GL ++Q AWA L+ A+ R Q L A Q + E+ AW E++ Sbjct: 3245 QLHP----AAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300 Query: 319 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQ 378 L SE+ +D QLL +H +L Q + L ++ + L++ H S +++ Sbjct: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360 Query: 379 SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 438 +++ L+E R + + L +L +++ + E W+A E + P+ G V Sbjct: 3361 QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV 3420 Query: 439 SVLQEKFSEFASETGMAGRERLAAVNQMVD 468 +L + + E +A +E A Q + Sbjct: 3421 ELLLHRHQDL--EKLLAAQEEKFAQMQKTE 3448 Score = 86.7 bits (213), Expect = 7e-17 Identities = 134/655 (20%), Positives = 267/655 (40%), Gaps = 46/655 (7%) Query: 21 RHQAFMAEL-AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79 +H+ F+ L AQ+K+ E RE + ++ VR +L + Q ++ +++ Sbjct: 2055 KHEVFLKVLTAQDKK--EAALRERLKTLRRP-----RVRDRLPILLQRRMRVKELAESRG 2107 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 L + Q+ + + + QL++ P GDL L K Q+ E++V+ Sbjct: 2108 HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHE 2167 Query: 140 REVGELQAQTAALPLEP------ASKELVGERQNAVGERLVRLL--EPLQERRRLLLASK 191 + + + AL + S+ L G R++ R L + L++RR L Sbjct: 2168 EVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL---- 2223 Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ---AVQQHIKKNQGLRREIQAHGPRLE 248 + +D AW+QE+ + G L+ +++ +++ +G + Sbjct: 2224 ---EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280 Query: 249 EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 308 + + + L + E + + + QL + WA R QQ L+ A ++ ++ Sbjct: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340 Query: 309 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 368 V + E+E L+ + D GKD +S +LL+KH +LE+ V + + L R+ L + Sbjct: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400 Query: 369 PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA-- 426 + + RQ +V + L+ ++RR AL+ + +L + EL ++ + + A Sbjct: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL--LVSAQRLRAQM 2458 Query: 427 -GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485 SP E +L+E E +E + + ++ +L+ GH ++ + + Sbjct: 2459 DTSPAPRSPVEARRMLEE-HQECKAELD-SWTDSISLARSTGQQLLTAGHPFSSDIRQVL 2516 Query: 486 DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR--LTTPPEPR 543 GL + + L L + EL F S +++ + K L L P P Sbjct: 2517 AGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPM 2576 Query: 544 PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIAS--REQEVLQGWK 601 + L E DL++ ++ L+ A R ++ G H EA ++ R Q +L + Sbjct: 2577 EPLLWKHKML---EWDLEVQAGKISALE---ATARGLHQGGHPEAQSALGRCQAMLLRKE 2630 Query: 602 ELLSACEDARLHVSSTADALRFHSQVRDLLSWM---DGIASQIGAADKPRCPSSL 653 L R + F +++ +W+ + +A + G D P+ L Sbjct: 2631 ALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685 Score = 59.3 bits (142), Expect = 1e-08 Identities = 121/605 (20%), Positives = 233/605 (38%), Gaps = 77/605 (12%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL-GEIRQCWAELESTTQAKAR 80 H A ++ LAQ L+ +++Q K A +++ L +R A LE T Q Sbjct: 550 HGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-- 607 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 + +++ E + L ++ + G DL+ + L+K +++E++V Sbjct: 608 ---------EFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQA 658 Query: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199 +L + L P ++ GER AV L + R L + + Q D Sbjct: 659 VCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFAD 718 Query: 200 LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP---RLEEVLERAGA 256 + +W++ER + G A + ++++ L R ++A RLEE A A Sbjct: 719 AAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASA 778 Query: 257 LASL------RSPEAEAVR------------------------------------RGLEQ 274 ASL SP E++R + + Sbjct: 779 RASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDH 838 Query: 275 LQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 334 L + LR A+ R+ L+ A + + E++ WL +Q +L+ D +Q Sbjct: 839 LSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQ 898 Query: 335 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394 L K+ + + A++S L + +S QI R+Q ++ + + L+ L E Sbjct: 899 L--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE 956 Query: 395 RRVALEQQYWLYQLSRQVSELEHWIAE--KEVVAGSPELGQDFEHVSVLQEKFSEFASET 452 + V L + ++ + + + ++ A P +D H L +K + Sbjct: 957 KAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT------ 1010 Query: 453 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 512 + R+ + +V ++ E G+ + + + L ++ E + RA+ A ++ Sbjct: 1011 -LVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQAR 1069 Query: 513 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQE 572 F ++++L E + +L E +S QR LR EH Q L+ ++ QE Sbjct: 1070 QSFLQESQQLLLWAESVQAQL----RSKEVSVDVASAQRLLR--EH--QDLLEEIHLWQE 1121 Query: 573 GAAQL 577 QL Sbjct: 1122 RLQQL 1126 Score = 58.2 bits (139), Expect = 3e-08 Identities = 106/492 (21%), Positives = 192/492 (39%), Gaps = 46/492 (9%) Query: 169 VGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228 V RL ++L LQE L + Q+ DL L W+ E+ + + L A++Q Sbjct: 255 VQRRLTKILLQLQETE---LLQTQYEQLVADL---LRWIAEKQMQLEARDFPDSLPAMRQ 308 Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR--------GLEQLQSAWA 280 + R Q PRL++ L L++ RR GL +L WA Sbjct: 309 LLAAFTIFRT--QEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWA 366 Query: 281 GLREAAERRQQVLDAAF--------QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQST 332 GL A R Q L ++ A E++L + E ++ D+ + ++ Sbjct: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVL---DQARAPPAS 423 Query: 333 LQLLKKHLQ----LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVD-RLYVA 387 L ++ +Q LE G+ E L+ L + + ++RRQ +V R Sbjct: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483 Query: 388 LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSE 447 L+ L +R+ + Q L L ++V H + E + A S GQ V L ++ Sbjct: 484 LQHLQGQRKQVADMQAVL-SLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDL 542 Query: 448 FASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLA 507 ++ G ++ + Q EL T+ + L + L+ L+ R LL Sbjct: 543 LEAQVSAHG-AHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLE 601 Query: 508 ASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ--RTLRAFEHDLQ-LLV 564 + + +F + E + ++E +R+ + A ++Q + L A H Q + V Sbjct: 602 QTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCV 661 Query: 565 SQVRQLQEGAAQLRTVY--AGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622 VR+ ++ +A+ GE AEA+ GW+ L + + + L+ Sbjct: 662 DLVRRGRDLSARRPPTQPDPGERAEAVQG-------GWQLLQTRVVGRGARLQTALLVLQ 714 Query: 623 FHSQVRDLLSWM 634 + + + SW+ Sbjct: 715 YFADAAEAASWL 726 Score = 52.0 bits (123), Expect = 2e-06 Identities = 133/676 (19%), Positives = 235/676 (34%), Gaps = 85/676 (12%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 +H+A AE+ +++ + R G+ L +P ++ ++ W L++ + Sbjct: 645 KHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGA 704 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +L A Q AE L S L+ G D A + L++ +E + + Sbjct: 705 RLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAA 764 Query: 141 EVGELQAQ-------------------------------------------TAALPLEP- 156 E+ L+ Q ALP EP Sbjct: 765 ELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPD 824 Query: 157 --ASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLA 214 + + Q+ + + L Q RR L + L + W++++ L Sbjct: 825 PDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL 884 Query: 215 MQTE-RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLE 273 + + + + L+ +Q K + + EV A L + ++R E Sbjct: 885 QRVQPQADTLEVMQ---LKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQE 941 Query: 274 QLQSAWAGLREAAERRQQVLDAAFQVEQYYF--DVAEVEAWLGEQELLMMSEDKGKDEQS 331 +L W L A +R++ + A VE F + + L + L + + G E + Sbjct: 942 ELSQRWGQLE--ALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDT 999 Query: 332 --TLQLL-KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVAL 388 LQL KK L LE+ V + + ++ E G+ +S+ + Q QV+ L L Sbjct: 1000 CHALQLAQKKTLVLERRVHFLQSVVVKVE-------EPGYAESQPL---QGQVETLQGLL 1049 Query: 389 KELGEE-----RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQE 443 K++ E+ RR A Q + Q +L W + S E+ D L Sbjct: 1050 KQVQEQVAQRARRQAETQARQSFLQESQ--QLLLWAESVQAQLRSKEVSVDVASAQRLLR 1107 Query: 444 KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRA 503 + + E + +ERL ++ + + + L + EL L R Sbjct: 1108 EHQDLLEEIHL-WQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQ 1166 Query: 504 QLLAASRELHKFFSDARELQGQIE--EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQ 561 Q L EL KF RE+ G + L E A S+ + R F L Sbjct: 1167 QWLQEGLELQKF---GREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLS 1223 Query: 562 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQGWKELLSACEDARLHVSSTAD 619 L + L+ +L +H A RE Q + W L E R + ++ Sbjct: 1224 TLGPRAEALRAHGEKL---VQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQ 1280 Query: 620 ALRFHSQVRDLLSWMD 635 + V +L+ WM+ Sbjct: 1281 LQEWKQDVAELMQWME 1296 >gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) isoform 2 [Homo sapiens] Length = 2472 Score = 203 bits (517), Expect = 4e-52 Identities = 171/638 (26%), Positives = 290/638 (45%), Gaps = 47/638 (7%) Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 M A D +D L + +HQAF AEL+ N+ ++ +E+ GQ+L+ V + Sbjct: 593 MKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAAR 652 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 + E+ W +L T+ K +L EA++ Q ++ +++ L +E L D G DL Sbjct: 653 MNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN 712 Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK---ELVGERQNAVGERLVRLL 177 V + KK +E+ V + + Q A + A E + ++Q A+ R L Sbjct: 713 VQNLQKKHALLEADVAAHQDRIDGITIQ--ARQFQDAGHFDAENIKKKQEALVARYEALK 770 Query: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237 EP+ R++ L S L Q+ D++DE W++E+ P+A T RG L VQ +KK+Q L+ Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830 Query: 238 REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297 EI H PR++ V ++ A+ AE V+ L +L W L+ A +R+Q L+ + Sbjct: 831 AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890 Query: 298 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357 Q +QY+ D E E+W+ E+E ++ S D GKDE S LLKKH L + Y SI L Sbjct: 891 QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950 Query: 358 RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLYQLSR----- 410 Q ++ + P ++ + L +AL + E+ R V +++ L L+ Sbjct: 951 EQAQSCRQQVAPTDDETGK------ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDW 1004 Query: 411 ---QVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467 +V++ + ++ V P Q ++L+E+ S +A + + Sbjct: 1005 WKVEVNDRQGFVPAAYVKKLDP--AQSASRENLLEEQGS-------------IALRQEQI 1049 Query: 468 DELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527 D A + K + E + LLEL R +L S + F +A ELQ I Sbjct: 1050 DNQTRITKEAGSVSLRMKQ-VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWIN 1108 Query: 528 EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAE 587 EK L + +Q+ F+ DL+ S+++ + + A L + G AE Sbjct: 1109 EKEAALTSEEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES--EGLMAE 1165 Query: 588 AIASREQEVLQGW-------KELLSACEDARLHVSSTA 618 + + +Q+ + G + S + ARL V + A Sbjct: 1166 EVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVA 1203 Score = 189 bits (479), Expect = 9e-48 Identities = 136/516 (26%), Positives = 239/516 (46%), Gaps = 6/516 (1%) Query: 4 ARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS---VRKK 60 A D + +D + + +HQAF AEL N + + + G L+ E+ A S V+ + Sbjct: 1574 ASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLI-ERGACAGSEDAVKAR 1632 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 L + W L + K+++L EA+K + D L +E+ L D G DLA+ Sbjct: 1633 LAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLAS 1692 Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA-SKELVGERQNAVGERLVRLLEP 179 VN+ LKK Q +E+ + + +L +Q +L A V ++++ + R ++ Sbjct: 1693 VNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSM 1752 Query: 180 LQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE 239 RR L S LHQ D+DDE +W++E+ L + G L VQ KK++ L E Sbjct: 1753 AASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAE 1812 Query: 240 IQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV 299 + AH P ++ VL+ L+ + E +++ L Q W L++ A R Q L+ + + Sbjct: 1813 LAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEY 1872 Query: 300 EQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ 359 +Q+ +V E EAW+ E+ L+ SED G + LLKKH E +++ + + Sbjct: 1873 QQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTN 1932 Query: 360 CRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWI 419 + L++ + E IS + ++ L++ +R+ L++ Q + + +E WI Sbjct: 1933 GQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWI 1992 Query: 420 AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAA 479 EKE + + G+D V L K F + +E +A + + D+L+ H + Sbjct: 1993 GEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSK 2052 Query: 480 TMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHK 514 + L + W++LL R +LL A K Sbjct: 2053 AIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRK 2088 Score = 157 bits (398), Expect = 2e-38 Identities = 135/560 (24%), Positives = 251/560 (44%), Gaps = 10/560 (1%) Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 RQ E S Q Q AE +K + + Q+ + D + +L+K Q+ E++V+ Sbjct: 37 RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANS 96 Query: 140 REVGELQAQTAALPLEPA--SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVA 197 + +L +T L + + E + R + + LLE ++E+ LL +++L Q Sbjct: 97 GAIVKLD-ETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYL 155 Query: 198 HDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 257 + +D + W+ ++ + E G L+ V+ KK + + ++ AH R+ EV + A L Sbjct: 156 RECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKL 215 Query: 258 ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQE 317 + PE E ++ +++ +AW L+ A +RQ L A +V+++ DV E +W+ E+E Sbjct: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKE 275 Query: 318 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP-DSEQISR 376 LM S+D G+D S LL+KH LE+ + E+ + L + L+ HP + QI Sbjct: 276 QLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADR-LQQSHPLSATQIQV 334 Query: 377 RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFE 436 ++ ++ + ++ L ER L Y L + +L W+ E + + + EL D Sbjct: 335 KREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVA 394 Query: 437 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELL 496 L ++ E E A + + ++ L+ GH A+ + E L+E A LL Sbjct: 395 GAEALLDRHQEHKGEID-AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALL 453 Query: 497 ELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAF 556 EL R Q +L F+ D ++ + ++ L + S ++ + F Sbjct: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN-EDLGDSLDSVEALLKKHEDF 512 Query: 557 EHDLQLLVSQVRQLQEGAAQLRTVYAGEHA-EAIASREQEVLQGWKELLSACEDARLHVS 615 E L ++ L E A +L + +A E +A+R +L L R ++ Sbjct: 513 EKSLSAQEEKITALDEFATKL--IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLA 570 Query: 616 STADALRFHSQVRDLLSWMD 635 + +F +L SW++ Sbjct: 571 DSFHLQQFFRDSDELKSWVN 590 Score = 154 bits (389), Expect = 3e-37 Identities = 142/617 (23%), Positives = 255/617 (41%), Gaps = 20/617 (3%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 + + F ++A ++E + ++ + +L+QE+ ++ K E+ W L+ + Sbjct: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +LF A++ + + E + E + D G DLA+V + L+K + +E + Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309 Query: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199 +V L A+ L P S + ++ + ++ ER L S L + D Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369 Query: 200 LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS 259 D +WV E L E + + + + ++Q + EI AH + E AL + Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429 Query: 260 LRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELL 319 ++ VR L L A L E E R+Q + ++ +Y D +V+ W+ +QE Sbjct: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489 Query: 320 MMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 379 +++ED G S LLKKH E+ + EE I L L++ H E ++ R+ Sbjct: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549 Query: 380 QVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 439 + AL E RR L + L Q R EL+ W+ EK A + E +D ++ Sbjct: 550 ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA-TDEAYKDPSNLQ 608 Query: 440 VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELM 499 +K F +E A + R+ A+ + +LI+ H A +A + + W +LLE Sbjct: 609 GKVQKHQAFEAELS-ANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667 Query: 500 GTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR------LTTPPEPRPSASSMQRTL 553 + L + + +F + +++ + E L LT + + ++ + Sbjct: 668 ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727 Query: 554 RAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLH 613 A + + + Q RQ Q+ AG ++QE L E L AR Sbjct: 728 AAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVARYEALKEPMVAR-- 776 Query: 614 VSSTADALRFHSQVRDL 630 AD+LR RD+ Sbjct: 777 KQKLADSLRLQQLFRDV 793 Score = 153 bits (386), Expect = 6e-37 Identities = 132/648 (20%), Positives = 286/648 (44%), Gaps = 11/648 (1%) Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61 LMA D D + +H+ +LA ++ ++ + E +L Q P A ++ K Sbjct: 277 LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336 Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121 E+ W ++ + + +L ++ + + + F +L + M++ + + D+A Sbjct: 337 EELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGA 396 Query: 122 NSQLKKLQSMESQV---EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178 + L + Q + ++ E+ ++ E + A L + + V E+ + E LLE Sbjct: 397 EALLDRHQEHKGEIDAHEDSFKSADE--SGQALLAAGHYASDEVREKLTVLSEERAALLE 454 Query: 179 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 238 + RR+ +L D + W+ ++ + + G+ L +V+ +KK++ + Sbjct: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514 Query: 239 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 298 + A ++ + E A L E V + L S L E A RR+ L +F Sbjct: 515 SLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFH 574 Query: 299 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 358 ++Q++ D E+++W+ E ++ +++ KD + ++KH E + + I L + Sbjct: 575 LQQFFRDSDELKSWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEK 633 Query: 359 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHW 418 + L+++ H ++++ R ++V L+ L E E + + L + Q +R V ++E W Sbjct: 634 AGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELW 693 Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 + E E S + G+D +V LQ+K + ++ A ++R+ + + + GH A Sbjct: 694 LYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA-AHQDRIDGITIQARQFQDAGHFDA 752 Query: 479 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTT 538 + + ++ L + L E M R Q LA S L + F D + + I EK + T Sbjct: 753 ENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK-EPIAASTN 811 Query: 539 PPEPRPSASSMQRTLRAFEHDLQLLVSQVRQL-QEGAAQLRTVYAGEHAEAIASREQEVL 597 + ++ + +A + ++ +++ + Q+G A + + AE + ++ E+ Sbjct: 812 RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFA--AEDVKAKLHELN 869 Query: 598 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645 Q W+ L + R + + A ++ + + SWM +G+ D Sbjct: 870 QKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTD 917 Score = 150 bits (380), Expect = 3e-36 Identities = 130/614 (21%), Positives = 272/614 (44%), Gaps = 19/614 (3%) Query: 42 EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKK 101 E ++ M EK + ++ E++Q W + + + + L + F + K Sbjct: 1081 EKRKGMLEKSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKD 1139 Query: 102 LLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKE 160 L ES+L+D++ DL + +++Q+++ Q E ++TA+ P + A Sbjct: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTAS-PWKSARLM 1198 Query: 161 L----VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQ 216 + + ER L + +ER +LL ++ E+ + D D+ W++E+ Sbjct: 1199 VHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNT 1258 Query: 217 TERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQ 276 G+ L +VQ +K++G R++ A G ++ + E A L AE ++ +L Sbjct: 1259 DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318 Query: 277 SAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLL 336 AW+ L + A++R+ L + ++++ D ++ +W+ L+ S++ KD LL Sbjct: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378 Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396 ++H + ++ + + + LL GH S +I ++ +D+ L++ +RR Sbjct: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438 Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456 + L+Q L R + E+W+A +E + + G + V L +K +F + Sbjct: 1439 MMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ- 1497 Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 516 E++AA+ D+LI GH A ++ ++ + + W L M + L S+ L +F Sbjct: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557 Query: 517 SDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ---RTLRAFEHDLQLLVSQVRQLQEG 573 D E++ I EK + T E +++Q + +AFE +L ++R + + Sbjct: 1558 RDVDEIEAWISEKLQ-----TASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDM 1612 Query: 574 AAQL--RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631 L R AG +A+ +R + W+ L+ + + F++ ++D Sbjct: 1613 GNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFD 1671 Query: 632 SWMDGIASQIGAAD 645 W+ + + + + D Sbjct: 1672 FWLSEVEALLASED 1685 Score = 144 bits (364), Expect = 2e-34 Identities = 107/382 (28%), Positives = 184/382 (48%), Gaps = 10/382 (2%) Query: 265 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 324 AE ++ +Q+ + +E + R+Q L+ +++ + + D E+E W+ +++L + S++ Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDE 70 Query: 325 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 384 KD + L+KH E V+ +I +L ++ GH SE I R ++ R Sbjct: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130 Query: 385 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 444 + L E E+ + L Q L Q R+ ++ WI +KE + S ELGQD EHV VLQ+K Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190 Query: 445 FSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQ 504 F EF ++ A ER+ VNQ +LI+ H + +D +N AW L L R Sbjct: 191 FEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249 Query: 505 LLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQ 561 L + E+ +F D E I+EK +L + +S+Q LR E DL Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKE----QLMASDDFGRDLASVQALLRKHEGLERDLA 305 Query: 562 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 621 L +V+ L A +L+ + A I + +E++ W+++ + + ++ + Sbjct: 306 ALEDKVKALCAEADRLQQSHP-LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364 Query: 622 RFHSQVRDLLSWMDGIASQIGA 643 RF + RDL SW+ + + I A Sbjct: 365 RFLADFRDLTSWVTEMKALINA 386 Score = 120 bits (301), Expect = 4e-27 Identities = 126/651 (19%), Positives = 271/651 (41%), Gaps = 31/651 (4%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 +H+ F +LA + + + ++L+Q PE A +++K E+ Q W+ L + Sbjct: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +L ++ + + F +L + + + + D+ + L++ Q ++++ Sbjct: 1334 KLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEID---A 1390 Query: 141 EVGELQA-----QTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQ 195 G QA Q AS E + ++ + + + L + +RR +L EL Sbjct: 1391 RAGTFQAFEQFGQQLLAHGHYASPE-IKQKLDILDQERADLEKAWVQRRMMLDQCLELQL 1449 Query: 196 VAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAG 255 D + W+ R ++G+ L +V+ IKK++ + I ++ + A Sbjct: 1450 FHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFAD 1509 Query: 256 ALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 315 L + + ++ W L+ ++ L + ++Q+ DV E+EAW+ E Sbjct: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE 1569 Query: 316 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG--HPDSEQ 373 +L S++ KD + +KH E + + I + +L+E G + Sbjct: 1570 -KLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA 1628 Query: 374 ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQ 433 + R + + + L + E+ L++ + + + + W++E E + S + G+ Sbjct: 1629 VKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGK 1688 Query: 434 DFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWA 493 D V+ L +K ++ A +RL +N D L+ + + + +D +N + Sbjct: 1689 DLASVNNLLKKHQLLEADIS-AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQ 1747 Query: 494 ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR------LTTPPEPRPSAS 547 ++ + +R L S LH+FF D + + I+EK+ + LT R Sbjct: 1748 KIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHK 1807 Query: 548 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKEL--LS 605 ++ L A E +Q ++ ++L + T+ E I R + ++ WKEL L+ Sbjct: 1808 RLEAELAAHEPAIQGVLDTGKKLSDD----NTI----GKEEIQQRLAQFVEHWKELKQLA 1859 Query: 606 ACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGL 656 A RL S + +F + V + +W++ + + + D +++ GL Sbjct: 1860 AARGQRLEES--LEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGL 1908 Score = 119 bits (299), Expect = 7e-27 Identities = 92/371 (24%), Positives = 168/371 (45%), Gaps = 2/371 (0%) Query: 160 ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER 219 E + ER+ V +R R E RR+ L S D ++ W+QE+L +A E Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA-SDEN 71 Query: 220 GNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW 279 +Q ++K+Q E+QA+ + ++ E + S +E +R L +L W Sbjct: 72 YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131 Query: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339 L E + L A ++ QY + +V W+ ++E ++ SE+ G+D + L KK Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191 Query: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVAL 399 + + + +EE + ++++ L++ HP+ E I +Q +V+ + LK L +R+ L Sbjct: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251 Query: 400 EQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 459 + + +R V E WI EKE + S + G+D V L K + A ++ Sbjct: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA-ALEDK 310 Query: 460 LAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDA 519 + A+ D L + +A + ++ L W ++ L R L S L +F +D Sbjct: 311 VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370 Query: 520 RELQGQIEEKR 530 R+L + E + Sbjct: 371 RDLTSWVTEMK 381 >gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) isoform 1 [Homo sapiens] Length = 2477 Score = 203 bits (517), Expect = 4e-52 Identities = 171/638 (26%), Positives = 290/638 (45%), Gaps = 47/638 (7%) Query: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60 M A D +D L + +HQAF AEL+ N+ ++ +E+ GQ+L+ V + Sbjct: 593 MKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAAR 652 Query: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120 + E+ W +L T+ K +L EA++ Q ++ +++ L +E L D G DL Sbjct: 653 MNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN 712 Query: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK---ELVGERQNAVGERLVRLL 177 V + KK +E+ V + + Q A + A E + ++Q A+ R L Sbjct: 713 VQNLQKKHALLEADVAAHQDRIDGITIQ--ARQFQDAGHFDAENIKKKQEALVARYEALK 770 Query: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237 EP+ R++ L S L Q+ D++DE W++E+ P+A T RG L VQ +KK+Q L+ Sbjct: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830 Query: 238 REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297 EI H PR++ V ++ A+ AE V+ L +L W L+ A +R+Q L+ + Sbjct: 831 AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890 Query: 298 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357 Q +QY+ D E E+W+ E+E ++ S D GKDE S LLKKH L + Y SI L Sbjct: 891 QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950 Query: 358 RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLYQLSR----- 410 Q ++ + P ++ + L +AL + E+ R V +++ L L+ Sbjct: 951 EQAQSCRQQVAPTDDETGK------ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDW 1004 Query: 411 ---QVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467 +V++ + ++ V P Q ++L+E+ S +A + + Sbjct: 1005 WKVEVNDRQGFVPAAYVKKLDP--AQSASRENLLEEQGS-------------IALRQEQI 1049 Query: 468 DELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527 D A + K + E + LLEL R +L S + F +A ELQ I Sbjct: 1050 DNQTRITKEAGSVSLRMKQ-VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWIN 1108 Query: 528 EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAE 587 EK L + +Q+ F+ DL+ S+++ + + A L + G AE Sbjct: 1109 EKEAALTSEEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES--EGLMAE 1165 Query: 588 AIASREQEVLQGW-------KELLSACEDARLHVSSTA 618 + + +Q+ + G + S + ARL V + A Sbjct: 1166 EVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVA 1203 Score = 188 bits (478), Expect = 1e-47 Identities = 137/515 (26%), Positives = 238/515 (46%), Gaps = 6/515 (1%) Query: 5 RDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS---VRKKL 61 +D T KL + +HQAF AEL N + + + G L+ E+ A S V+ +L Sbjct: 1580 KDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLI-ERGACAGSEDAVKARL 1638 Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121 + W L + K+++L EA+K + D L +E+ L D G DLA+V Sbjct: 1639 AALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASV 1698 Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA-SKELVGERQNAVGERLVRLLEPL 180 N+ LKK Q +E+ + + +L +Q +L A V ++++ + R ++ Sbjct: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMA 1758 Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 RR L S LHQ D+DDE +W++E+ L + G L VQ KK++ L E+ Sbjct: 1759 ASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL 1818 Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 AH P ++ VL+ L+ + E +++ L Q W L++ A R Q L+ + + + Sbjct: 1819 AAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQ 1878 Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 Q+ +V E EAW+ E+ L+ SED G + LLKKH E +++ + + Sbjct: 1879 QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNG 1938 Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420 + L++ + E IS + ++ L++ +R+ L++ Q + + +E WI Sbjct: 1939 QDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIG 1998 Query: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480 EKE + + G+D V L K F + +E +A + + D+L+ H + Sbjct: 1999 EKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKA 2058 Query: 481 MAEWKDGLNEAWAELLELMGTR-AQLLAASRELHK 514 + L + W++LL R +LL A K Sbjct: 2059 IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRK 2093 Score = 157 bits (398), Expect = 2e-38 Identities = 135/560 (24%), Positives = 251/560 (44%), Gaps = 10/560 (1%) Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 RQ E S Q Q AE +K + + Q+ + D + +L+K Q+ E++V+ Sbjct: 37 RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANS 96 Query: 140 REVGELQAQTAALPLEPA--SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVA 197 + +L +T L + + E + R + + LLE ++E+ LL +++L Q Sbjct: 97 GAIVKLD-ETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYL 155 Query: 198 HDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 257 + +D + W+ ++ + E G L+ V+ KK + + ++ AH R+ EV + A L Sbjct: 156 RECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKL 215 Query: 258 ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQE 317 + PE E ++ +++ +AW L+ A +RQ L A +V+++ DV E +W+ E+E Sbjct: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKE 275 Query: 318 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP-DSEQISR 376 LM S+D G+D S LL+KH LE+ + E+ + L + L+ HP + QI Sbjct: 276 QLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADR-LQQSHPLSATQIQV 334 Query: 377 RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFE 436 ++ ++ + ++ L ER L Y L + +L W+ E + + + EL D Sbjct: 335 KREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVA 394 Query: 437 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELL 496 L ++ E E A + + ++ L+ GH A+ + E L+E A LL Sbjct: 395 GAEALLDRHQEHKGEID-AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALL 453 Query: 497 ELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAF 556 EL R Q +L F+ D ++ + ++ L + S ++ + F Sbjct: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN-EDLGDSLDSVEALLKKHEDF 512 Query: 557 EHDLQLLVSQVRQLQEGAAQLRTVYAGEHA-EAIASREQEVLQGWKELLSACEDARLHVS 615 E L ++ L E A +L + +A E +A+R +L L R ++ Sbjct: 513 EKSLSAQEEKITALDEFATKL--IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLA 570 Query: 616 STADALRFHSQVRDLLSWMD 635 + +F +L SW++ Sbjct: 571 DSFHLQQFFRDSDELKSWVN 590 Score = 154 bits (389), Expect = 3e-37 Identities = 142/617 (23%), Positives = 255/617 (41%), Gaps = 20/617 (3%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 + + F ++A ++E + ++ + +L+QE+ ++ K E+ W L+ + Sbjct: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +LF A++ + + E + E + D G DLA+V + L+K + +E + Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309 Query: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199 +V L A+ L P S + ++ + ++ ER L S L + D Sbjct: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369 Query: 200 LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS 259 D +WV E L E + + + + ++Q + EI AH + E AL + Sbjct: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429 Query: 260 LRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELL 319 ++ VR L L A L E E R+Q + ++ +Y D +V+ W+ +QE Sbjct: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489 Query: 320 MMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 379 +++ED G S LLKKH E+ + EE I L L++ H E ++ R+ Sbjct: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549 Query: 380 QVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 439 + AL E RR L + L Q R EL+ W+ EK A + E +D ++ Sbjct: 550 ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA-TDEAYKDPSNLQ 608 Query: 440 VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELM 499 +K F +E A + R+ A+ + +LI+ H A +A + + W +LLE Sbjct: 609 GKVQKHQAFEAELS-ANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667 Query: 500 GTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR------LTTPPEPRPSASSMQRTL 553 + L + + +F + +++ + E L LT + + ++ + Sbjct: 668 ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727 Query: 554 RAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLH 613 A + + + Q RQ Q+ AG ++QE L E L AR Sbjct: 728 AAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVARYEALKEPMVAR-- 776 Query: 614 VSSTADALRFHSQVRDL 630 AD+LR RD+ Sbjct: 777 KQKLADSLRLQQLFRDV 793 Score = 153 bits (386), Expect = 6e-37 Identities = 132/648 (20%), Positives = 286/648 (44%), Gaps = 11/648 (1%) Query: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61 LMA D D + +H+ +LA ++ ++ + E +L Q P A ++ K Sbjct: 277 LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336 Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121 E+ W ++ + + +L ++ + + + F +L + M++ + + D+A Sbjct: 337 EELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGA 396 Query: 122 NSQLKKLQSMESQV---EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178 + L + Q + ++ E+ ++ E + A L + + V E+ + E LLE Sbjct: 397 EALLDRHQEHKGEIDAHEDSFKSADE--SGQALLAAGHYASDEVREKLTVLSEERAALLE 454 Query: 179 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 238 + RR+ +L D + W+ ++ + + G+ L +V+ +KK++ + Sbjct: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514 Query: 239 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 298 + A ++ + E A L E V + L S L E A RR+ L +F Sbjct: 515 SLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFH 574 Query: 299 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 358 ++Q++ D E+++W+ E ++ +++ KD + ++KH E + + I L + Sbjct: 575 LQQFFRDSDELKSWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEK 633 Query: 359 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHW 418 + L+++ H ++++ R ++V L+ L E E + + L + Q +R V ++E W Sbjct: 634 AGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELW 693 Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 + E E S + G+D +V LQ+K + ++ A ++R+ + + + GH A Sbjct: 694 LYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA-AHQDRIDGITIQARQFQDAGHFDA 752 Query: 479 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTT 538 + + ++ L + L E M R Q LA S L + F D + + I EK + T Sbjct: 753 ENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK-EPIAASTN 811 Query: 539 PPEPRPSASSMQRTLRAFEHDLQLLVSQVRQL-QEGAAQLRTVYAGEHAEAIASREQEVL 597 + ++ + +A + ++ +++ + Q+G A + + AE + ++ E+ Sbjct: 812 RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFA--AEDVKAKLHELN 869 Query: 598 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645 Q W+ L + R + + A ++ + + SWM +G+ D Sbjct: 870 QKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTD 917 Score = 149 bits (377), Expect = 6e-36 Identities = 130/617 (21%), Positives = 271/617 (43%), Gaps = 20/617 (3%) Query: 42 EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKK 101 E ++ M EK + ++ E++Q W + + + + L + F + K Sbjct: 1081 EKRKGMLEKSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKD 1139 Query: 102 LLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKE 160 L ES+L+D++ DL + +++Q+++ Q E ++TA+ P + A Sbjct: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTAS-PWKSARLM 1198 Query: 161 L----VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQ 216 + + ER L + +ER +LL ++ E+ + D D+ W++E+ Sbjct: 1199 VHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNT 1258 Query: 217 TERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQ 276 G+ L +VQ +K++G R++ A G ++ + E A L AE ++ +L Sbjct: 1259 DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318 Query: 277 SAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLL 336 AW+ L + A++R+ L + ++++ D ++ +W+ L+ S++ KD LL Sbjct: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378 Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396 ++H + ++ + + + LL GH S +I ++ +D+ L++ +RR Sbjct: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438 Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456 + L+Q L R + E+W+A +E + + G + V L +K +F + Sbjct: 1439 MMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ- 1497 Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 516 E++AA+ D+LI GH A ++ ++ + + W L M + L S+ L +F Sbjct: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557 Query: 517 SDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL------RAFEHDLQLLVSQVRQL 570 D E++ I EK L + P+ + + L +AFE +L ++R + Sbjct: 1558 RDVDEIEAWISEK---LQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGV 1614 Query: 571 QEGAAQL--RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVR 628 + L R AG +A+ +R + W+ L+ + + F++ ++ Sbjct: 1615 IDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK 1673 Query: 629 DLLSWMDGIASQIGAAD 645 D W+ + + + + D Sbjct: 1674 DFDFWLSEVEALLASED 1690 Score = 144 bits (364), Expect = 2e-34 Identities = 107/382 (28%), Positives = 184/382 (48%), Gaps = 10/382 (2%) Query: 265 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 324 AE ++ +Q+ + +E + R+Q L+ +++ + + D E+E W+ +++L + S++ Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDE 70 Query: 325 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 384 KD + L+KH E V+ +I +L ++ GH SE I R ++ R Sbjct: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130 Query: 385 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 444 + L E E+ + L Q L Q R+ ++ WI +KE + S ELGQD EHV VLQ+K Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190 Query: 445 FSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQ 504 F EF ++ A ER+ VNQ +LI+ H + +D +N AW L L R Sbjct: 191 FEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249 Query: 505 LLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQ 561 L + E+ +F D E I+EK +L + +S+Q LR E DL Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKE----QLMASDDFGRDLASVQALLRKHEGLERDLA 305 Query: 562 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 621 L +V+ L A +L+ + A I + +E++ W+++ + + ++ + Sbjct: 306 ALEDKVKALCAEADRLQQSHP-LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364 Query: 622 RFHSQVRDLLSWMDGIASQIGA 643 RF + RDL SW+ + + I A Sbjct: 365 RFLADFRDLTSWVTEMKALINA 386 Score = 121 bits (304), Expect = 2e-27 Identities = 126/658 (19%), Positives = 276/658 (41%), Gaps = 40/658 (6%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 +H+ F +LA + + + ++L+Q PE A +++K E+ Q W+ L + Sbjct: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 +L ++ + + F +L + + + + D+ + L++ Q ++++ Sbjct: 1334 KLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEID---A 1390 Query: 141 EVGELQA-----QTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQ 195 G QA Q AS E + ++ + + + L + +RR +L EL Sbjct: 1391 RAGTFQAFEQFGQQLLAHGHYASPE-IKQKLDILDQERADLEKAWVQRRMMLDQCLELQL 1449 Query: 196 VAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAG 255 D + W+ R ++G+ L +V+ IKK++ + I ++ + A Sbjct: 1450 FHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFAD 1509 Query: 256 ALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 315 L + + ++ W L+ ++ L + ++Q+ DV E+EAW+ E Sbjct: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE 1569 Query: 316 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP------ 369 + L + D+ + + +Q L K L Q + +E + + + R +++MG+ Sbjct: 1570 K--LQTASDESYKDPTNIQ-LSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626 Query: 370 ---DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426 + + R + + + L + E+ L++ + + + + W++E E + Sbjct: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686 Query: 427 GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD 486 S + G+D V+ L +K ++ A +RL +N D L+ + + + +D Sbjct: 1687 ASEDYGKDLASVNNLLKKHQLLEADIS-AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRD 1745 Query: 487 GLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR------LTTPP 540 +N + ++ + +R L S LH+FF D + + I+EK+ + LT Sbjct: 1746 TINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ 1805 Query: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600 R ++ L A E +Q ++ ++L + T+ E I R + ++ W Sbjct: 1806 NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDD----NTI----GKEEIQQRLAQFVEHW 1857 Query: 601 KEL--LSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGL 656 KEL L+A RL S + +F + V + +W++ + + + D +++ GL Sbjct: 1858 KELKQLAAARGQRLEES--LEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGL 1913 Score = 119 bits (299), Expect = 7e-27 Identities = 92/371 (24%), Positives = 168/371 (45%), Gaps = 2/371 (0%) Query: 160 ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER 219 E + ER+ V +R R E RR+ L S D ++ W+QE+L +A E Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA-SDEN 71 Query: 220 GNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW 279 +Q ++K+Q E+QA+ + ++ E + S +E +R L +L W Sbjct: 72 YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131 Query: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339 L E + L A ++ QY + +V W+ ++E ++ SE+ G+D + L KK Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191 Query: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVAL 399 + + + +EE + ++++ L++ HP+ E I +Q +V+ + LK L +R+ L Sbjct: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251 Query: 400 EQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 459 + + +R V E WI EKE + S + G+D V L K + A ++ Sbjct: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA-ALEDK 310 Query: 460 LAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDA 519 + A+ D L + +A + ++ L W ++ L R L S L +F +D Sbjct: 311 VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370 Query: 520 RELQGQIEEKR 530 R+L + E + Sbjct: 371 RDLTSWVTEMK 381 >gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] Length = 2419 Score = 185 bits (469), Expect = 1e-46 Identities = 143/643 (22%), Positives = 281/643 (43%), Gaps = 9/643 (1%) Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIR 65 D + ED + ++ +HQ+ AE+ + ++E+ ++ + + E+R Sbjct: 78 DKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELR 137 Query: 66 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 125 W L T K QL A K Q VQ A++ + + E+ V+ G D Sbjct: 138 HLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLH 197 Query: 126 KKLQSMESQVEEWYREVGELQ--AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183 KK + + ++ V E+ A A P L+ +QN V RL +R Sbjct: 198 KKFEDFQVELVAKEGRVVEVNQYANECAEENHP-DLPLIQSKQNEVNAAWERLRGLALQR 256 Query: 184 RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243 ++ L + L + D+ + + W++E+ P+ + G L A + ++GL R + Sbjct: 257 QKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVM 316 Query: 244 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 303 +++E+ +A L +A ++ E L S+W +R A R + L A + ++ Sbjct: 317 SDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFS 376 Query: 304 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 363 D E+ W+ E+ + +++ D LL +H Q + +++Y++ + L Sbjct: 377 SDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDL 436 Query: 364 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423 + H S+++ + +D + AL EL +ER EQ + R +++ W++ +E Sbjct: 437 VNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQE 496 Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 483 + +LG L +K +F E A E++ V++ +LI H + + Sbjct: 497 AFLENEDLGNSLGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555 Query: 484 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPR 543 +DGL L E TR +LL S L K + D+ +L+ I K+++L + + Sbjct: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWI-NKKKKLADDEDYKDIQ 614 Query: 544 PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA-EAIASREQEVLQGWKE 602 S +Q+ + FE +L + +Q+ +Q+ ++ + G +A + + +R EV W+E Sbjct: 615 NLKSRVQKQ-QVFEKELAVNKTQLENIQKTGQEM--IEGGHYASDNVTTRLSEVASLWEE 671 Query: 603 LLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645 LL A + + L+F + DL W++ + Q+ + D Sbjct: 672 LLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSED 714 Score = 164 bits (415), Expect = 2e-40 Identities = 116/378 (30%), Positives = 184/378 (48%), Gaps = 3/378 (0%) Query: 3 MARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG 62 +A D +D L R + Q F ELA NK LE I++ GQ++++ + +V +L Sbjct: 604 LADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLS 663 Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVN 122 E+ W EL T+ K QL EA++ Q + +L + L +E Q+ D G LA V Sbjct: 664 EVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQ 723 Query: 123 SQLKKLQSMESQVEEWYREVGELQAQTAALPL--EPASKELVGERQNAVGERLVRLLEPL 180 ++L+K +ES V +V L A P SK+ + RQ ++ R L EPL Sbjct: 724 NRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKD-IRARQESLVCRFEALKEPL 782 Query: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 R++ LL L + D +DE AW+QE P A T G L A ++ + +++ + I Sbjct: 783 ATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENI 842 Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 +H PR++E+ ER + AE V ++ L LR A RRQ L+A Q + Sbjct: 843 ASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQ 902 Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 QY D+ E E W+ E+E ++ + + G DE++ LLKKH + ++ +S+ L Q Sbjct: 903 QYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQA 962 Query: 361 RALLEMGHPDSEQISRRQ 378 A + E ++ Q Sbjct: 963 NACQQQQAAPVEGVAGEQ 980 Score = 160 bits (406), Expect = 3e-39 Identities = 126/511 (24%), Positives = 226/511 (44%), Gaps = 10/511 (1%) Query: 4 ARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP--ELAASVRKKL 61 A D + +D + +++L+HQ F E+ E + + G L++ +++++L Sbjct: 1523 ACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQL 1582 Query: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121 ++++ W L T K ++L EAS+ + S + + L E+ L D DLA+ Sbjct: 1583 EQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASA 1642 Query: 122 NSQLKKLQSMESQV---EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178 + LKK Q +E ++ E+ +++ L L + + + ++++ V +R + + E Sbjct: 1643 GNLLKKHQLLEREMLAREDALKDLNTLAEDL--LSSGTFNVDQIVKKKDNVNKRFLNVQE 1700 Query: 179 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 238 L + L Q DLDDE +W++E+L + G LQ VQ +KK++ L Sbjct: 1701 LAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEG 1760 Query: 239 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 298 E+ AH P ++ VL+ A L + E ++ L Q W L+E A+ R L+ + + Sbjct: 1761 ELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLE 1820 Query: 299 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 358 Q+ + E EAW+ E+ L + D G +T LL KH LE +E + + Sbjct: 1821 YLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCA 1880 Query: 359 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGE---ERRVALEQQYWLYQLSRQVSEL 415 Q +L + Q S+++ L L + ++ LE Y + + + + Sbjct: 1881 QGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVV 1940 Query: 416 EHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH 475 E WIA+KE + G D L K + +ERL + + D+LI H Sbjct: 1941 EAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQH 2000 Query: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLL 506 + + E L + W +LLE Q L Sbjct: 2001 NQSKAIEERYAALLKRWEQLLEASAVHRQKL 2031 Score = 143 bits (360), Expect = 6e-34 Identities = 132/564 (23%), Positives = 236/564 (41%), Gaps = 22/564 (3%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 RHQ E+ + + + GQ L+ E + VR+K+ + W L + R Sbjct: 411 RHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHR 470 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 Q + + ++D + E+ L++ D G L + + L+K + E Sbjct: 471 QYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEE 530 Query: 141 EVGELQAQTAALPLEPASKELVG------ERQNAVGERLVRLLEPLQE----RRRLLLAS 190 ++ + ++ + +L+G E A+ + L+ + L+E RRRLL S Sbjct: 531 KI---------ITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKES 581 Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 L ++ D DD W+ ++ LA E +Q ++ ++K Q +E+ + +LE + Sbjct: 582 LLLQKLYEDSDDLKNWINKKKKLA-DDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENI 640 Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVE 310 + + ++ V L ++ S W L EA +++ L A Q Q+ + +++ Sbjct: 641 QKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQ 700 Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 WL + E + SED GK L+KH LE V ++ + L+ E+GHPD Sbjct: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPD 760 Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430 S+ I RQ + + ALKE R+ L L + R + E WI E E A S Sbjct: 761 SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY 820 Query: 431 LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNE 490 LG+D L + E + R+ + + ++++E GH AA +A LN+ Sbjct: 821 LGKDLIASKKLLNRHRVIL-ENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQ 879 Query: 491 AWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ 550 L R L A+ + ++ +D E + I EK + T +A ++ Sbjct: 880 NMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDN-TNYGADEEAAGALL 938 Query: 551 RTLRAFEHDLQLLVSQVRQLQEGA 574 + AF DL ++ L+ A Sbjct: 939 KKHEAFLLDLNSFGDSMKALRNQA 962 Score = 128 bits (321), Expect = 2e-29 Identities = 109/485 (22%), Positives = 221/485 (45%), Gaps = 33/485 (6%) Query: 162 VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGN 221 + +RQ + + LL+ +ERRR LL +A++ D L W+QE+ G Sbjct: 1053 ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAENTGV 1108 Query: 222 GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA--SLRSPEAEAVRRGLEQLQSAW 279 L V + KK ++++ + PRL ++ + A L L +PE +R ++L S W Sbjct: 1109 ELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR---QELNSRW 1165 Query: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339 L+ A+ ++Q+L +A VE ++ + + + + ++ + + D G D S L ++H Sbjct: 1166 GSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRH 1225 Query: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPD-SEQISRRQSQVDRLYVALKELGEERRVA 398 E+ + + + L L E HPD +E + R++ +++ + L+ ++R+ + Sbjct: 1226 EGFERDLVPLGDKVTILGETAERLSE-SHPDATEDLQRQKMELNEAWEDLQGRTKDRKES 1284 Query: 399 LEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRE 458 L + Y + +L++WI+ + S EL +D + +L E+ E ++ A Sbjct: 1285 LNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADM-EAEAP 1343 Query: 459 RLAAVNQMVDELIECGHTAAATMAE-------WKDGLNEAWAELLELMGTRAQLLAASRE 511 A+ ELI+ GH A+ + + +D L +AW + R ++L E Sbjct: 1344 TFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK-------RKKILDQCLE 1396 Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571 L F + +++ + + L + + S S++ ++ + + + +Q ++ Sbjct: 1397 LQMFQGNCDQVESWMVARENSL-----RSDDKSSLDSLEALMKKRDDLDKAITAQEGKIT 1451 Query: 572 EGAAQLRTVYAGEH--AEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRD 629 + ++ A EH E IA+R Q VL WK L + D R + A+ +F+ + + Sbjct: 1452 DLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEE 1511 Query: 630 LLSWM 634 L W+ Sbjct: 1512 LEEWI 1516 Score = 125 bits (315), Expect = 1e-28 Identities = 116/483 (24%), Positives = 199/483 (41%), Gaps = 20/483 (4%) Query: 160 ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER 219 E + ER+ V R E + ER + L S L D DD W+ E++ + Sbjct: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY 81 Query: 220 GNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW 279 + +Q +K+Q L E+Q + E+ + ++ E + +E+L+ W Sbjct: 82 EDPTN-IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140 Query: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339 L E + L A + +QY + A++ W+G++E + S + G+D + T L KK Sbjct: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200 Query: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVAL 399 + + E + ++++ E HPD I +Q++V+ + L+ L +R+ AL Sbjct: 201 EDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKAL 260 Query: 400 EQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 459 L + R V+E WI EKE V S + G+D L F S G+ Sbjct: 261 SNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKD------LVASEGLFHSHKGL--ERN 312 Query: 460 LAAVNQMVDEL------IECGHTA-AATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 512 LA ++ V EL + H + A + E K+ L +W + L +R + L A+ Sbjct: 313 LAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWY 372 Query: 513 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQE 572 H+F SD EL G + EK + P + + R + +H++ + + E Sbjct: 373 HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRH-QQHKHEIDSYDDRFQSADE 431 Query: 573 GAAQLRTVYAGEHAEAIASREQEVL-QGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631 L V A A + E+L W LL ++ D F+ + Sbjct: 432 TGQDL--VNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVD 489 Query: 632 SWM 634 SWM Sbjct: 490 SWM 492 Score = 117 bits (292), Expect = 5e-26 Identities = 92/386 (23%), Positives = 179/386 (46%), Gaps = 10/386 (2%) Query: 265 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 324 AE ++ +++ + + +E R Q L+ ++ ++ + D ++ W+ E+ ++ D Sbjct: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILT--D 78 Query: 325 KGKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383 K ++ + +Q +KH LE V+ +++L + MGH E+ ++ Sbjct: 79 KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRH 138 Query: 384 LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQE 443 L+ L EL E+ L + Q ++ +++ WI +KE +A S ELG+D+E VL + Sbjct: 139 LWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHK 198 Query: 444 KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRA 503 KF +F E +A R+ VNQ +E E H + ++ +N AW L L R Sbjct: 199 KFEDFQVEL-VAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257 Query: 504 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS--MQRTLRAFEHDLQ 561 + L+ + L +F D E I+EK P LT+ + +S + + + E +L Sbjct: 258 KALSNAANLQRFKRDVTEAIQWIKEKE---PVLTSEDYGKDLVASEGLFHSHKGLERNLA 314 Query: 562 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 621 ++ +V++L A +L T+ A I +++++ W+ + + + +T Sbjct: 315 VMSDKVKELCAKAEKL-TLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYH 373 Query: 622 RFHSQVRDLLSWMDGIASQIGAADKP 647 RF S +L WM+ + I A + P Sbjct: 374 RFSSDFDELSGWMNEKTAAINADELP 399 Score = 115 bits (287), Expect = 2e-25 Identities = 124/634 (19%), Positives = 269/634 (42%), Gaps = 40/634 (6%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 RH+ F +L + + + ++L + P+ ++++ E+ + W +L+ T+ + Sbjct: 1224 RHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKE 1283 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 L EA K + +L + + + + DL + L++ Q + +E Sbjct: 1284 SLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA--- 1340 Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGE--------RLVR--LLEPLQERRRLLLAS 190 E QA LE S EL+ +A E +L R L + ++R+++L Sbjct: 1341 EAPTFQA------LEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQC 1394 Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 EL + D +W+ R +++++ + L +++ +KK L + I A ++ ++ Sbjct: 1395 LELQMFQGNCDQVESWMVAR-ENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDL 1453 Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEV 309 A +L + E + L+++ W L+ + + R ++ D A ++Q+Y D+ E+ Sbjct: 1454 EHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYA-NLKQFYRDLEEL 1512 Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369 E W+ E L ++ KD + + KH V+ E + + +L+E Sbjct: 1513 EEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSAC 1571 Query: 370 DS------EQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423 D EQ+ + + D L + G++ A QQ + + + + E W++E E Sbjct: 1572 DGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQ----RFNTSIRDFEFWLSEAE 1627 Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 483 + + +D L +K E +A + L +N + ++L+ G + + Sbjct: 1628 TLLAMKDQARDLASAGNLLKKHQLLEREM-LAREDALKDLNTLAEDLLSSGTFNVDQIVK 1686 Query: 484 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPR 543 KD +N+ + + EL + L + L +FF D + + IEEK L R+++ R Sbjct: 1687 KKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEK---LIRVSSQDYGR 1743 Query: 544 --PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWK 601 ++ + + E +L ++ + + A +L+ A E I R + ++ W+ Sbjct: 1744 DLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKD-KAAVGQEEIQLRLAQFVEHWE 1802 Query: 602 ELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635 +L + L + + + L+F + +W++ Sbjct: 1803 KLKELAKARGLKLEESLEYLQFMQNAEEEEAWIN 1836 Score = 108 bits (270), Expect = 2e-23 Identities = 139/650 (21%), Positives = 271/650 (41%), Gaps = 28/650 (4%) Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE---KPELAASVRKKLGEIRQ 66 +D +L K++ F +L N+ L I + L+ E PE A +R+ E+ Sbjct: 1111 DDVWELQKKF---DEFQKDLNTNEPRLRDINKVADDLLFEGLLTPE-GAQIRQ---ELNS 1163 Query: 67 CWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQ-LQDVDPGGDLATVNSQL 125 W L+ + RQL ++ A ++ A+ K+ + + Q L DPG DL +V + Sbjct: 1164 RWGSLQRLADEQ-RQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQ 1222 Query: 126 KKLQSMESQVEEWYREVGELQAQTAAL-PLEPASKELVGERQNAVGERLVRLLEPLQERR 184 ++ + E + +V L L P + E + ++ + E L ++R+ Sbjct: 1223 RRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRK 1282 Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244 L +++ + D W+ + E L ++ ++++Q R +++A Sbjct: 1283 ESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEA 1342 Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304 P + + + + L + + + L+ ++ L +A E+R+++LD +++ + Sbjct: 1343 PTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQG 1402 Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364 + +VE+W+ +E + S+DK + S L+KK L++ + E I L +L+ Sbjct: 1403 NCDQVESWMVARENSLRSDDKSSLD-SLEALMKKRDDLDKAITAQEGKITDLEHFAESLI 1461 Query: 365 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 424 H E+I+ R +V + ALK + R L L Q R + ELE WI+E + Sbjct: 1462 ADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM-L 1520 Query: 425 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGR-ERLAAVNQMVDELIECGHTAA--ATM 481 E +D ++ K FA E + GR E++ V + + LIEC M Sbjct: 1521 PTACDESYKDATNIQRKYLKHQTFAHE--VDGRSEQVHGVINLGNSLIECSACDGNEEAM 1578 Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541 E + L E W LLE + + L + +F + R+ + + E L + Sbjct: 1579 KEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLL-AMKDQAR 1637 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWK 601 SA ++ + + E ++ ++ L A L + + + I ++ V K Sbjct: 1638 DLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLS-SGTFNVDQIVKKKDNVN---K 1693 Query: 602 ELLSACEDARLHVSSTADA---LRFHSQVRDLLSWMDGIASQIGAADKPR 648 L+ E A H +A +F + D SW++ ++ + D R Sbjct: 1694 RFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGR 1743 Score = 83.2 bits (204), Expect = 7e-16 Identities = 120/634 (18%), Positives = 252/634 (39%), Gaps = 52/634 (8%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 RH+ + +A ++ +++I G ++++E A V ++ + Q L + + Sbjct: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQN 893 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 L + Q + E + + E + + + G D + LKK ++ + + Sbjct: 894 DLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGD 953 Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER--RRLLLASKELHQVAH 198 + L+ Q A + A+ + GE+ V L Q R R + + ++ + Sbjct: 954 SMKALRNQANACQQQQAAPV-----EGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLS 1008 Query: 199 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258 ++ + W E A Q I +RR P L + Sbjct: 1009 SINKDW-WKVEA--------------ADHQGIVPAVYVRRLAHDEFPMLPQ--------- 1044 Query: 259 SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQEL 318 R E + + EQ+++ + L + AE R++ L + ++ ++ W+ E++ Sbjct: 1045 -RRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK- 1102 Query: 319 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG--HPDSEQISR 376 +E+ G + +L KK + ++ + E + +++ LL G P+ QI Sbjct: 1103 ---AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQI-- 1157 Query: 377 RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFE 436 + +++ + +L+ L +E+R L + + R+ + + I +K + + G D Sbjct: 1158 -RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLF 1216 Query: 437 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELL 496 V LQ + F + G +++ + + + L E A + K LNEAW +L Sbjct: 1217 SVQALQRRHEGFERDLVPLG-DKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQ 1275 Query: 497 ELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL-RA 555 R + L +++ + F S AR+LQ I + + + E + ++ L R Sbjct: 1276 GRTKDRKESLNEAQKFYLFLSKARDLQNWISS----IGGMVSSQELAEDLTGIEILLERH 1331 Query: 556 FEH--DLQLLVSQVRQLQEGAAQLRTVYAGEHAE-AIASREQEVLQGWKELLSACEDARL 612 EH D++ + L++ +A+L + +G HA I + Q V +L A E + Sbjct: 1332 QEHRADMEAEAPTFQALEDFSAEL--IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKK 1389 Query: 613 HVSSTADALRFHSQVRDLLSWMDGIASQIGAADK 646 + + F + SWM + + + DK Sbjct: 1390 ILDQCLELQMFQGNCDQVESWMVARENSLRSDDK 1423 >gi|221316624 dystonin isoform 4 [Homo sapiens] Length = 5526 Score = 97.1 bits (240), Expect = 5e-20 Identities = 136/675 (20%), Positives = 286/675 (42%), Gaps = 65/675 (9%) Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 74 L ++ H+ +A++K ++K+ + G QL++ P S+++K +++++ Sbjct: 3916 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3975 Query: 75 TQAKARQLFEA--------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ-- 124 + +A L EA K DQ+++S + ++L S +V+ + + N Sbjct: 3976 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVS 4035 Query: 125 --LKKLQ----SMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNA---VGERLVR 175 ++KLQ +++ + EE G +A ++ ++V +N V ER + Sbjct: 4036 VDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAK 4095 Query: 176 LLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228 LL+ ++ + L++ K+ DL+D G V+Q Sbjct: 4096 LLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----------------GIDPSVVKQ 4139 Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAE 287 + + +R EI L+ V+ L A+ P+ V++ +++L SAW L +A + Sbjct: 4140 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK 4199 Query: 288 RRQQVLDAAFQVEQYYFD-VAEVEAW--LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344 R L+ A Q Y D + V W + +L MS G D ++ Q +++ Q + Sbjct: 4200 DRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKS 4258 Query: 345 GVENYEESIAQLSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQ 402 + + +L+ Q LL+ +S++ + ++ ++ +L+E R+ LE Sbjct: 4259 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4318 Query: 403 YW-LYQLSRQVSELEHWIAEKE-VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460 L Q + EL W+ E +++ +G D + + + K ++ +A + + Sbjct: 4319 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTV 4377 Query: 461 AAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAELLELMGTRAQLL-AASRELHKFFSD 518 AVN+ ++LIE A+ + K + LN+ W +LE R Q L A R+ F + Sbjct: 4378 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGE 4437 Query: 519 ARELQGQIEEKRRRL----PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA 574 +LQ + + R L P P + + AFE + S +++ Q+ Sbjct: 4438 IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML 4497 Query: 575 AQLRTVYAGEHAEAIASRE-QEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLS 632 A+ + AE ++ + + W+ + + + + + + A+ FH+ ++D ++ Sbjct: 4498 AR-----CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4552 Query: 633 WMDGIASQIGAADKP 647 W+ + A +P Sbjct: 4553 WLTQAEQTLNVASRP 4567 Score = 68.9 bits (167), Expect = 1e-11 Identities = 114/593 (19%), Positives = 241/593 (40%), Gaps = 63/593 (10%) Query: 92 VQSFAELDKKLLHMESQLQDVDPGGD-LATVNSQLKKLQSMESQVEEWYREVGELQAQT- 149 +Q + M SQ + D D +A V + LQ + ++ + +++ L A Sbjct: 3113 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3172 Query: 150 -------AALPLEPASKELVGERQN--AVGERLVRLLEPLQERRRLLLAS-KELHQVAHD 199 L E S +LVG +++ A+ ++ +LL+ Q R + + K L + Sbjct: 3173 NANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3232 Query: 200 LDDELAWVQE-------RLPLAMQTERGNGLQAV-----QQHIKKNQGLRREIQAHGPRL 247 L + +Q+ + P+ M+TE N + ++ I+ QG ++++ G L Sbjct: 3233 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3292 Query: 248 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQVEQYYFDV 306 + ++ +S + + L+ + + W L ++ A+R Q+ +A ++ + Sbjct: 3293 IQ--------SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3344 Query: 307 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESIAQLSRQCRA 362 + +W+ + E L+ ++ K + +++K +Q L++ +++ + ++ + R+ Sbjct: 3345 ESLLSWMVDTEELVANQ---KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3401 Query: 363 LLEMGHP-DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE-LEHWIA 420 + P D +I ++ S +D + AL E R LE + Q + E L W+ Sbjct: 3402 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3461 Query: 421 --EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 EK +V P Q S L+E+ ++ A + + N+ + + + G + Sbjct: 3462 TIEKRLVNCEPIGTQ----ASKLEEQIAQHK-----ALEDDIINHNKHLHQAVSIGQSLK 3512 Query: 479 AT-------MAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFS-DARELQGQIEEK 529 M + K ++ W E+ E +R++LL + K F D EL + E Sbjct: 3513 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEV 3572 Query: 530 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 589 +L +L+ Q LR + D+ L V Q +L G+ I Sbjct: 3573 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3632 Query: 590 ASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLSWMDGIASQI 641 + + + +K++ D + A R HS +L +W+D + ++ Sbjct: 3633 QDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3685 Score = 66.6 bits (161), Expect = 7e-11 Identities = 120/645 (18%), Positives = 256/645 (39%), Gaps = 51/645 (7%) Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79 LR Q L E L++ + ++Q+K E + K + ++ A+ A Sbjct: 3605 LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3664 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 R+L S ++L +++ +LL E+Q+ + +LKK + + Sbjct: 3665 RRLH--STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3722 Query: 140 REVGELQAQTAALPLEPASKELVGE---RQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 EV + +++V E R V + + + +E + +L S++ Q Sbjct: 3723 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA---ILRSQQFDQA 3779 Query: 197 AHDLDDELAWVQE---RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253 A D EL+W+ E +L + Q ++K EI H ++++++ Sbjct: 3780 A---DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT--FTMEILRHKDIIDDLVKS 3834 Query: 254 AGALASLRSPEA-EAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVAEVEA 311 + + S E +++++ L+++ + + + +ER Q+ A V Q++ E+ Sbjct: 3835 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3894 Query: 312 WLGEQELLMMSEDKGKDEQSTL-QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 WL E + ++ E TL Q ++H QL + + ++ I ++++ LLE+ + Sbjct: 3895 WLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGE 3954 Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQ------------QYWLYQLSRQVSELEHW 418 I + D LY +KE ++R VAL++ L L R V L Sbjct: 3955 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4014 Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 + V E + ++VSV EK G E +A ++ +A Sbjct: 4015 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI------SA 4068 Query: 479 ATMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537 + + D + W + L+ R A+LL KF+ D L I++ + + L Sbjct: 4069 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLE 4128 Query: 538 TP-------PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 590 P + + +A +++ + + +L ++++ +L + + + + Sbjct: 4129 DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELN 4188 Query: 591 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635 S + + WK+ + E+A A+++ ++ + W+D Sbjct: 4189 SAWDSLNKAWKDRIDKLEEA------MQAAVQYQDGLQAVFDWVD 4227 Score = 57.8 bits (138), Expect = 3e-08 Identities = 84/361 (23%), Positives = 169/361 (46%), Gaps = 40/361 (11%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELESTTQAK 78 ++++F AEL QN +++++ + +L++E P+ + R K L EI W EL T + Sbjct: 2500 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2559 Query: 79 ARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVE 136 ++L E+S Q A+L + L+ E + + P D +N+Q +++Q + ++ Sbjct: 2560 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL---LQ 2616 Query: 137 EWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER----RR 185 E+ + + TAA P E P+ + +V E+ AV ++ L L +R + Sbjct: 2617 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2676 Query: 186 LLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243 ++ S + + L D+L+ + +L LA+ T A+ Q ++ Q +++EIQ Sbjct: 2677 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMKQEIQQE 2732 Query: 244 GPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 ++ + + E AL +AE + R LE + ++ + + AE Q L +A Sbjct: 2733 KKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2791 Query: 301 QYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ-LEQGVENYEESIAQLSR 358 + ++ + +AWL D K+EQ+ + L LE ++++++ L+ Sbjct: 2792 HQFQQMSRDFQAWL----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2841 Query: 359 Q 359 Q Sbjct: 2842 Q 2842 Score = 54.3 bits (129), Expect = 4e-07 Identities = 124/668 (18%), Positives = 248/668 (37%), Gaps = 80/668 (11%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 H+ F L EK EG+ L+ + + A+++ +L I+ W + + Sbjct: 2832 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2891 Query: 81 QLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 +L E+ KA + + L + ++ L+++ D A + + KL+S++ ++++ + Sbjct: 2892 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2951 Query: 140 REVGELQAQTA--ALPLEPASKELVGERQNAVGERLVRLLEPLQERR----RLLLASKEL 193 V EL TA L + KE+V + ++ +++ + E L ++ + KE Sbjct: 2952 GMV-ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEF 3010 Query: 194 HQVAHDLDDELAWVQERLP----LAMQTERGNGLQAVQQHIKKNQGLRREIQ-------- 241 +V+ + +L +E+L L Q L +Q K Q L+ ++ Sbjct: 3011 QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3070 Query: 242 -----AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296 + +VL + +A S ++ V L++ G+ +++ Sbjct: 3071 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3130 Query: 297 FQVEQYYFDVAEV--------------EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQL 342 + + +A V +A+L + E LM S D T +++ + Sbjct: 3131 AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN---KTCKMMLATEET 3187 Query: 343 EQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQ 402 + + + LS+QC LL+ EQ+ +++ Y LKE + L++ Sbjct: 3188 SPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS----ILLQK- 3242 Query: 403 YWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462 AE+ + P +G + E ++ F F E + + Sbjct: 3243 -----------------AEEHEESQGP-VGMETETINQQLNMFKVFQKEEIEPLQGKQQD 3284 Query: 463 VNQMVDELIECGHTAAAT--MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 520 VN + LI+ + +T + D +N W L + + RA L + F DA Sbjct: 3285 VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3344 Query: 521 ELQGQIEEKRRRLPRLTTPPEPR----PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576 E L PP + Q+ L+ D + V +++ E A Sbjct: 3345 ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT 3404 Query: 577 LRTVYAGEHAEAIASREQEVL--QGWKELLSACEDARLHVSS-TADALRFHSQVRDLLSW 633 E A+ + +Q L W+ LL+ E + + A +FH + L W Sbjct: 3405 -----TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3459 Query: 634 MDGIASQI 641 + I ++ Sbjct: 3460 LTTIEKRL 3467 Score = 53.9 bits (128), Expect = 5e-07 Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%) Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 362 V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A Sbjct: 637 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 696 Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422 L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK Sbjct: 697 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 747 Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482 E + + + +++ ++ +E E E + +V ++ ++L+ H A T+ Sbjct: 748 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 806 Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535 ++ + W+ +L+L Q + + +FF+DA+E + + + R Sbjct: 807 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 859 Score = 52.0 bits (123), Expect = 2e-06 Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%) Query: 48 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 107 Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + + Sbjct: 454 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 507 Query: 108 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 153 + V G + T + + + + + G Q+ T +L Sbjct: 508 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 567 Query: 154 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + PA LV + V ++ L+ +Q R+ LL +S + Sbjct: 568 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 627 Query: 197 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 + + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E Sbjct: 628 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 687 Query: 251 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 + A L+ AE + R L+S +A L + +++ LD + + Sbjct: 688 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 740 Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369 WL E+E ++ D + + + H +L + ++ EE+I + LL HP Sbjct: 741 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 800 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 414 I E R A++ Q+ W+ QL + V + Sbjct: 801 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 828 Score = 49.7 bits (117), Expect = 9e-06 Identities = 128/682 (18%), Positives = 268/682 (39%), Gaps = 83/682 (12%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQAKA 79 +H ++ ++ +E + + G L++ E A++++ KL + Q W + T+ + Sbjct: 4362 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4421 Query: 80 RQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VNSQLKKLQSMES 133 +QL A + A +L + L E L P G L +N ++ + E+ Sbjct: 4422 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4481 Query: 134 QVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKE 192 + EE Y+ + +Q L P S E + + N + E+ + L ER+ L + Sbjct: 4482 K-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4538 Query: 193 LHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 L H+ L D + W+ Q L + + L V I +++ E+ +H ++ E Sbjct: 4539 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIE- 4597 Query: 251 LERAGA-----------------LASLRSPEAEAVRRGLE-------------QLQSAWA 280 L++ G L S++S + V+R +E Q AW+ Sbjct: 4598 LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4657 Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE----QELLMMSEDKGKDEQSTLQLL 336 L E E ++ LD+ ++ D +++ L + Q+ L T + L Sbjct: 4658 KLMEWLEESEKSLDSELEIAN---DPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4714 Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396 K+ L ++ +++L + + + RQ++++ + + + + Sbjct: 4715 KEKTSLADDNLKLDDMLSELRDKWDTI-------CGKSVERQNKLEEALLFSGQFTDALQ 4767 Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456 ++ WLY++ Q +AE + V G D + V L + F E G Sbjct: 4768 ALID---WLYRVEPQ-------LAEDQPVHG------DIDLVMNLIDNHKAFQKELGKR- 4810 Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKF 515 + A+ + ELIE ++ + L+ W + L + + +L AA R+ +F Sbjct: 4811 TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEF 4870 Query: 516 FSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575 S L + E + L P+ + ++ + F ++ L + +L + Sbjct: 4871 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATT 4927 Query: 576 QLRTVYAGEHAEAIASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LL 631 TV A H ++I + + + ++E+L+ + + ++S L ++ + LL Sbjct: 4928 MGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALL 4987 Query: 632 SWMDGIASQIGAADKPRCPSSL 653 +W+ + + DK P + Sbjct: 4988 AWLQWAETTLTDKDKEVIPQEI 5009 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%) Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 164 M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E Sbjct: 647 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 704 Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224 + + + + +LL + + R L LH +EL W+ E+ + + Sbjct: 705 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 761 Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284 + + + L RE+ ++ V E A L P + +Q+ W+ + + Sbjct: 762 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 821 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 341 + +Q + +++ D E +L + + S D+ L+++ ++ Sbjct: 822 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 881 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 372 ++ + Y+ +IA L + + ++++ +S+ Sbjct: 882 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 912 Score = 40.4 bits (93), Expect = 0.005 Identities = 85/454 (18%), Positives = 178/454 (39%), Gaps = 65/454 (14%) Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95 L+++E E + L +EK E ++ Q W S T A + + + Q + S Sbjct: 1454 LKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISKTLKDAEKAGKPPFSKQKISS- 1507 Query: 96 AELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQSMESQVEEWYR-----EVGELQ 146 E+ K + LQ + GD T + + +L+ ++E Y + +LQ Sbjct: 1508 EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEKQVKTLQESYNLLFSESLKQLQ 1566 Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206 + ++ K +V ERQ E+L + + L + L+ +E + D EL Sbjct: 1567 ESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG-DGTVELKK 1624 Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----IQAHGPRLEEVLERAGALASLR 261 Q + +Q + QA+ + +K + +E Q +E+ L A Sbjct: 1625 YQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1683 Query: 262 SPEAEAVRRGLEQLQS-----------AWAGLREAAERRQQVLDAAFQVEQ--------- 301 + +AE ++ L+++ + A L E+ + + +LD V++ Sbjct: 1684 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1743 Query: 302 --------YYFDVAEVEAWLGEQE-----LLMMSEDK--GKDEQSTLQLLKKHLQLEQGV 346 +F + ++ +GE++ LL D G +++ Q +K + + Sbjct: 1744 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKI 1803 Query: 347 ENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQVDRLY-VALKELGEERRVALE 400 + +++ ++ + LLE + + E++ + ++ Y AL E ++ ++ Sbjct: 1804 ISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS 1863 Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD 434 Q L + +E EHW+ + E + E G D Sbjct: 1864 LQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1897 Score = 40.4 bits (93), Expect = 0.005 Identities = 145/722 (20%), Positives = 282/722 (39%), Gaps = 131/722 (18%) Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 62 +D + L + R ++F ++ +K L I G +++ E A S K+ G Sbjct: 1897 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1952 Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 120 R+ +L+ T + R L+ SK + L + +L K H E + G AT Sbjct: 1953 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2009 Query: 121 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 160 + L + ++++ Q+EE G++ +Q A+ L PA + Sbjct: 2010 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2069 Query: 161 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 218 + + VG R L + + ER +L + V LD+ L W+ L Q + Sbjct: 2070 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2128 Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 277 A+Q I KN L ++I + + E+ P A +++ ++ L + Sbjct: 2129 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2188 Query: 278 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 328 ++ EA+ + ++ L + +VE + +++ +L + + D GKD Sbjct: 2189 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2245 Query: 329 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 369 ++ST + L KKHL++ G+ + + E LS++ + + + Sbjct: 2246 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2305 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429 E ++ Q Q+D V +K L + W+ + +++V ++ G+ Sbjct: 2306 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2348 Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 487 +LG+ E LQEK+S E ++ N LI T A +A K G Sbjct: 2349 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2403 Query: 488 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 541 LN E A E L + +++ H + L+ +I E +L +L E Sbjct: 2404 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2463 Query: 542 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 575 P P+ + +T ++FE +L+ V++V++L++ Sbjct: 2464 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2523 Query: 576 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 632 +L + EA ++ E+ W+EL D + + +++ L +F + L Sbjct: 2524 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2582 Query: 633 WM 634 W+ Sbjct: 2583 WL 2584 Score = 37.7 bits (86), Expect = 0.035 Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 83/465 (17%) Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93 +W++++E +++ + +PE + ++ +L + + +E+E + SK D+ Q Sbjct: 1333 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKMDE-CQ 1381 Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGELQAQTA 150 +AE + + +LQ + A V+SQ K K + M+S + +E +L+ + Sbjct: 1382 KYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1437 Query: 151 ALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLDDELAW 206 AL L+ + G+ L RL E +E++ + +KEL + ++ L Sbjct: 1438 AL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1491 Query: 207 VQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGALASLR 261 ++ + P + Q + ++ + + Q ++ + HG ++ EE E + +L+ Sbjct: 1492 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1551 Query: 262 SPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYYFDVAE 308 L+QLQ + +E E+ Q + D Q E Sbjct: 1552 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE-------- 1603 Query: 309 VEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ESIAQLS 357 +G QE M+ + + K QS + L+K +Q L + V+N E E+ +LS Sbjct: 1604 -NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1662 Query: 358 RQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQYWLYQL 408 ++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q L + Sbjct: 1663 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ--LEES 1718 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 453 ++ L W++ V S G +H V+++ + F G Sbjct: 1719 KTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1759 Score = 35.4 bits (80), Expect = 0.17 Identities = 69/371 (18%), Positives = 144/371 (38%), Gaps = 57/371 (15%) Query: 3 MARDGTRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 56 M DGT E +L K +AE+ +N E ++ G++L QE L Sbjct: 1614 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL--- 1668 Query: 57 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 116 + +KL E + +L + ++L D++V + + + + + QL++ Sbjct: 1669 IEQKLNEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE----- 1717 Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176 + + L L +++ E + ++ Q E K +GE G L Sbjct: 1718 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----L 1773 Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236 LE D+D ++ QE L Q + + + QH Sbjct: 1774 LET-------------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH------- 1807 Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295 + + + +LE+ G S E E +++ +++L+ + L E+ ++ + Sbjct: 1808 -QAVIIATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1864 Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354 ++E++ D E E WL + E + + + G D+ + L LK+ + V +++ + Sbjct: 1865 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1924 Query: 355 QLSRQCRALLE 365 ++ +LE Sbjct: 1925 YITISGNRVLE 1935 >gi|221316622 dystonin isoform 3 [Homo sapiens] Length = 5537 Score = 97.1 bits (240), Expect = 5e-20 Identities = 136/675 (20%), Positives = 286/675 (42%), Gaps = 65/675 (9%) Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 74 L ++ H+ +A++K ++K+ + G QL++ P S+++K +++++ Sbjct: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3986 Query: 75 TQAKARQLFEA--------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ-- 124 + +A L EA K DQ+++S + ++L S +V+ + + N Sbjct: 3987 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVS 4046 Query: 125 --LKKLQ----SMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNA---VGERLVR 175 ++KLQ +++ + EE G +A ++ ++V +N V ER + Sbjct: 4047 VDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAK 4106 Query: 176 LLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228 LL+ ++ + L++ K+ DL+D G V+Q Sbjct: 4107 LLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----------------GIDPSVVKQ 4150 Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAE 287 + + +R EI L+ V+ L A+ P+ V++ +++L SAW L +A + Sbjct: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK 4210 Query: 288 RRQQVLDAAFQVEQYYFD-VAEVEAW--LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344 R L+ A Q Y D + V W + +L MS G D ++ Q +++ Q + Sbjct: 4211 DRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKS 4269 Query: 345 GVENYEESIAQLSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQ 402 + + +L+ Q LL+ +S++ + ++ ++ +L+E R+ LE Sbjct: 4270 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4329 Query: 403 YW-LYQLSRQVSELEHWIAEKE-VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460 L Q + EL W+ E +++ +G D + + + K ++ +A + + Sbjct: 4330 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTV 4388 Query: 461 AAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAELLELMGTRAQLL-AASRELHKFFSD 518 AVN+ ++LIE A+ + K + LN+ W +LE R Q L A R+ F + Sbjct: 4389 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGE 4448 Query: 519 ARELQGQIEEKRRRL----PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA 574 +LQ + + R L P P + + AFE + S +++ Q+ Sbjct: 4449 IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML 4508 Query: 575 AQLRTVYAGEHAEAIASRE-QEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLS 632 A+ + AE ++ + + W+ + + + + + + A+ FH+ ++D ++ Sbjct: 4509 AR-----CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4563 Query: 633 WMDGIASQIGAADKP 647 W+ + A +P Sbjct: 4564 WLTQAEQTLNVASRP 4578 Score = 68.9 bits (167), Expect = 1e-11 Identities = 114/593 (19%), Positives = 241/593 (40%), Gaps = 63/593 (10%) Query: 92 VQSFAELDKKLLHMESQLQDVDPGGD-LATVNSQLKKLQSMESQVEEWYREVGELQAQT- 149 +Q + M SQ + D D +A V + LQ + ++ + +++ L A Sbjct: 3124 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3183 Query: 150 -------AALPLEPASKELVGERQN--AVGERLVRLLEPLQERRRLLLAS-KELHQVAHD 199 L E S +LVG +++ A+ ++ +LL+ Q R + + K L + Sbjct: 3184 NANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3243 Query: 200 LDDELAWVQE-------RLPLAMQTERGNGLQAV-----QQHIKKNQGLRREIQAHGPRL 247 L + +Q+ + P+ M+TE N + ++ I+ QG ++++ G L Sbjct: 3244 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3303 Query: 248 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQVEQYYFDV 306 + ++ +S + + L+ + + W L ++ A+R Q+ +A ++ + Sbjct: 3304 IQ--------SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3355 Query: 307 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESIAQLSRQCRA 362 + +W+ + E L+ ++ K + +++K +Q L++ +++ + ++ + R+ Sbjct: 3356 ESLLSWMVDTEELVANQ---KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3412 Query: 363 LLEMGHP-DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE-LEHWIA 420 + P D +I ++ S +D + AL E R LE + Q + E L W+ Sbjct: 3413 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3472 Query: 421 --EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 EK +V P Q S L+E+ ++ A + + N+ + + + G + Sbjct: 3473 TIEKRLVNCEPIGTQ----ASKLEEQIAQHK-----ALEDDIINHNKHLHQAVSIGQSLK 3523 Query: 479 AT-------MAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFS-DARELQGQIEEK 529 M + K ++ W E+ E +R++LL + K F D EL + E Sbjct: 3524 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEV 3583 Query: 530 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 589 +L +L+ Q LR + D+ L V Q +L G+ I Sbjct: 3584 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3643 Query: 590 ASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLSWMDGIASQI 641 + + + +K++ D + A R HS +L +W+D + ++ Sbjct: 3644 QDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3696 Score = 66.6 bits (161), Expect = 7e-11 Identities = 120/645 (18%), Positives = 256/645 (39%), Gaps = 51/645 (7%) Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79 LR Q L E L++ + ++Q+K E + K + ++ A+ A Sbjct: 3616 LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3675 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 R+L S ++L +++ +LL E+Q+ + +LKK + + Sbjct: 3676 RRLH--STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3733 Query: 140 REVGELQAQTAALPLEPASKELVGE---RQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 EV + +++V E R V + + + +E + +L S++ Q Sbjct: 3734 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA---ILRSQQFDQA 3790 Query: 197 AHDLDDELAWVQE---RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253 A D EL+W+ E +L + Q ++K EI H ++++++ Sbjct: 3791 A---DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT--FTMEILRHKDIIDDLVKS 3845 Query: 254 AGALASLRSPEA-EAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVAEVEA 311 + + S E +++++ L+++ + + + +ER Q+ A V Q++ E+ Sbjct: 3846 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3905 Query: 312 WLGEQELLMMSEDKGKDEQSTL-QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 WL E + ++ E TL Q ++H QL + + ++ I ++++ LLE+ + Sbjct: 3906 WLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGE 3965 Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQ------------QYWLYQLSRQVSELEHW 418 I + D LY +KE ++R VAL++ L L R V L Sbjct: 3966 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4025 Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 + V E + ++VSV EK G E +A ++ +A Sbjct: 4026 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI------SA 4079 Query: 479 ATMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537 + + D + W + L+ R A+LL KF+ D L I++ + + L Sbjct: 4080 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLE 4139 Query: 538 TP-------PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 590 P + + +A +++ + + +L ++++ +L + + + + Sbjct: 4140 DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELN 4199 Query: 591 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635 S + + WK+ + E+A A+++ ++ + W+D Sbjct: 4200 SAWDSLNKAWKDRIDKLEEA------MQAAVQYQDGLQAVFDWVD 4238 Score = 57.8 bits (138), Expect = 3e-08 Identities = 84/361 (23%), Positives = 169/361 (46%), Gaps = 40/361 (11%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELESTTQAK 78 ++++F AEL QN +++++ + +L++E P+ + R K L EI W EL T + Sbjct: 2511 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2570 Query: 79 ARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVE 136 ++L E+S Q A+L + L+ E + + P D +N+Q +++Q + ++ Sbjct: 2571 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL---LQ 2627 Query: 137 EWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER----RR 185 E+ + + TAA P E P+ + +V E+ AV ++ L L +R + Sbjct: 2628 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2687 Query: 186 LLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243 ++ S + + L D+L+ + +L LA+ T A+ Q ++ Q +++EIQ Sbjct: 2688 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMKQEIQQE 2743 Query: 244 GPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 ++ + + E AL +AE + R LE + ++ + + AE Q L +A Sbjct: 2744 KKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2802 Query: 301 QYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ-LEQGVENYEESIAQLSR 358 + ++ + +AWL D K+EQ+ + L LE ++++++ L+ Sbjct: 2803 HQFQQMSRDFQAWL----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2852 Query: 359 Q 359 Q Sbjct: 2853 Q 2853 Score = 54.3 bits (129), Expect = 4e-07 Identities = 124/668 (18%), Positives = 248/668 (37%), Gaps = 80/668 (11%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 H+ F L EK EG+ L+ + + A+++ +L I+ W + + Sbjct: 2843 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2902 Query: 81 QLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 +L E+ KA + + L + ++ L+++ D A + + KL+S++ ++++ + Sbjct: 2903 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2962 Query: 140 REVGELQAQTA--ALPLEPASKELVGERQNAVGERLVRLLEPLQERR----RLLLASKEL 193 V EL TA L + KE+V + ++ +++ + E L ++ + KE Sbjct: 2963 GMV-ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEF 3021 Query: 194 HQVAHDLDDELAWVQERLP----LAMQTERGNGLQAVQQHIKKNQGLRREIQ-------- 241 +V+ + +L +E+L L Q L +Q K Q L+ ++ Sbjct: 3022 QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3081 Query: 242 -----AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296 + +VL + +A S ++ V L++ G+ +++ Sbjct: 3082 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3141 Query: 297 FQVEQYYFDVAEV--------------EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQL 342 + + +A V +A+L + E LM S D T +++ + Sbjct: 3142 AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN---KTCKMMLATEET 3198 Query: 343 EQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQ 402 + + + LS+QC LL+ EQ+ +++ Y LKE + L++ Sbjct: 3199 SPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS----ILLQK- 3253 Query: 403 YWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462 AE+ + P +G + E ++ F F E + + Sbjct: 3254 -----------------AEEHEESQGP-VGMETETINQQLNMFKVFQKEEIEPLQGKQQD 3295 Query: 463 VNQMVDELIECGHTAAAT--MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 520 VN + LI+ + +T + D +N W L + + RA L + F DA Sbjct: 3296 VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3355 Query: 521 ELQGQIEEKRRRLPRLTTPPEPR----PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576 E L PP + Q+ L+ D + V +++ E A Sbjct: 3356 ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT 3415 Query: 577 LRTVYAGEHAEAIASREQEVL--QGWKELLSACEDARLHVSS-TADALRFHSQVRDLLSW 633 E A+ + +Q L W+ LL+ E + + A +FH + L W Sbjct: 3416 -----TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3470 Query: 634 MDGIASQI 641 + I ++ Sbjct: 3471 LTTIEKRL 3478 Score = 53.9 bits (128), Expect = 5e-07 Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%) Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 362 V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A Sbjct: 648 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 707 Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422 L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK Sbjct: 708 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 758 Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482 E + + + +++ ++ +E E E + +V ++ ++L+ H A T+ Sbjct: 759 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 817 Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535 ++ + W+ +L+L Q + + +FF+DA+E + + + R Sbjct: 818 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 870 Score = 52.0 bits (123), Expect = 2e-06 Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%) Query: 48 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 107 Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + + Sbjct: 465 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 518 Query: 108 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 153 + V G + T + + + + + G Q+ T +L Sbjct: 519 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 578 Query: 154 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + PA LV + V ++ L+ +Q R+ LL +S + Sbjct: 579 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 638 Query: 197 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 + + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E Sbjct: 639 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 698 Query: 251 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 + A L+ AE + R L+S +A L + +++ LD + + Sbjct: 699 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 751 Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369 WL E+E ++ D + + + H +L + ++ EE+I + LL HP Sbjct: 752 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 811 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 414 I E R A++ Q+ W+ QL + V + Sbjct: 812 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 839 Score = 49.7 bits (117), Expect = 9e-06 Identities = 128/682 (18%), Positives = 268/682 (39%), Gaps = 83/682 (12%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQAKA 79 +H ++ ++ +E + + G L++ E A++++ KL + Q W + T+ + Sbjct: 4373 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4432 Query: 80 RQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VNSQLKKLQSMES 133 +QL A + A +L + L E L P G L +N ++ + E+ Sbjct: 4433 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4492 Query: 134 QVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKE 192 + EE Y+ + +Q L P S E + + N + E+ + L ER+ L + Sbjct: 4493 K-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4549 Query: 193 LHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 L H+ L D + W+ Q L + + L V I +++ E+ +H ++ E Sbjct: 4550 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIE- 4608 Query: 251 LERAGA-----------------LASLRSPEAEAVRRGLE-------------QLQSAWA 280 L++ G L S++S + V+R +E Q AW+ Sbjct: 4609 LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4668 Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE----QELLMMSEDKGKDEQSTLQLL 336 L E E ++ LD+ ++ D +++ L + Q+ L T + L Sbjct: 4669 KLMEWLEESEKSLDSELEIAN---DPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725 Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396 K+ L ++ +++L + + + RQ++++ + + + + Sbjct: 4726 KEKTSLADDNLKLDDMLSELRDKWDTI-------CGKSVERQNKLEEALLFSGQFTDALQ 4778 Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456 ++ WLY++ Q +AE + V G D + V L + F E G Sbjct: 4779 ALID---WLYRVEPQ-------LAEDQPVHG------DIDLVMNLIDNHKAFQKELGKR- 4821 Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKF 515 + A+ + ELIE ++ + L+ W + L + + +L AA R+ +F Sbjct: 4822 TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEF 4881 Query: 516 FSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575 S L + E + L P+ + ++ + F ++ L + +L + Sbjct: 4882 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATT 4938 Query: 576 QLRTVYAGEHAEAIASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LL 631 TV A H ++I + + + ++E+L+ + + ++S L ++ + LL Sbjct: 4939 MGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALL 4998 Query: 632 SWMDGIASQIGAADKPRCPSSL 653 +W+ + + DK P + Sbjct: 4999 AWLQWAETTLTDKDKEVIPQEI 5020 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%) Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 164 M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E Sbjct: 658 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 715 Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224 + + + + +LL + + R L LH +EL W+ E+ + + Sbjct: 716 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 772 Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284 + + + L RE+ ++ V E A L P + +Q+ W+ + + Sbjct: 773 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 832 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 341 + +Q + +++ D E +L + + S D+ L+++ ++ Sbjct: 833 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 892 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 372 ++ + Y+ +IA L + + ++++ +S+ Sbjct: 893 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 923 Score = 40.4 bits (93), Expect = 0.005 Identities = 85/454 (18%), Positives = 178/454 (39%), Gaps = 65/454 (14%) Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95 L+++E E + L +EK E ++ Q W S T A + + + Q + S Sbjct: 1465 LKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISKTLKDAEKAGKPPFSKQKISS- 1518 Query: 96 AELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQSMESQVEEWYR-----EVGELQ 146 E+ K + LQ + GD T + + +L+ ++E Y + +LQ Sbjct: 1519 EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEKQVKTLQESYNLLFSESLKQLQ 1577 Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206 + ++ K +V ERQ E+L + + L + L+ +E + D EL Sbjct: 1578 ESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG-DGTVELKK 1635 Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----IQAHGPRLEEVLERAGALASLR 261 Q + +Q + QA+ + +K + +E Q +E+ L A Sbjct: 1636 YQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1694 Query: 262 SPEAEAVRRGLEQLQS-----------AWAGLREAAERRQQVLDAAFQVEQ--------- 301 + +AE ++ L+++ + A L E+ + + +LD V++ Sbjct: 1695 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1754 Query: 302 --------YYFDVAEVEAWLGEQE-----LLMMSEDK--GKDEQSTLQLLKKHLQLEQGV 346 +F + ++ +GE++ LL D G +++ Q +K + + Sbjct: 1755 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKI 1814 Query: 347 ENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQVDRLY-VALKELGEERRVALE 400 + +++ ++ + LLE + + E++ + ++ Y AL E ++ ++ Sbjct: 1815 ISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS 1874 Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD 434 Q L + +E EHW+ + E + E G D Sbjct: 1875 LQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1908 Score = 40.4 bits (93), Expect = 0.005 Identities = 145/722 (20%), Positives = 282/722 (39%), Gaps = 131/722 (18%) Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 62 +D + L + R ++F ++ +K L I G +++ E A S K+ G Sbjct: 1908 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1963 Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 120 R+ +L+ T + R L+ SK + L + +L K H E + G AT Sbjct: 1964 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2020 Query: 121 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 160 + L + ++++ Q+EE G++ +Q A+ L PA + Sbjct: 2021 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2080 Query: 161 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 218 + + VG R L + + ER +L + V LD+ L W+ L Q + Sbjct: 2081 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139 Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 277 A+Q I KN L ++I + + E+ P A +++ ++ L + Sbjct: 2140 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2199 Query: 278 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 328 ++ EA+ + ++ L + +VE + +++ +L + + D GKD Sbjct: 2200 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2256 Query: 329 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 369 ++ST + L KKHL++ G+ + + E LS++ + + + Sbjct: 2257 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2316 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429 E ++ Q Q+D V +K L + W+ + +++V ++ G+ Sbjct: 2317 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2359 Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 487 +LG+ E LQEK+S E ++ N LI T A +A K G Sbjct: 2360 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2414 Query: 488 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 541 LN E A E L + +++ H + L+ +I E +L +L E Sbjct: 2415 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2474 Query: 542 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 575 P P+ + +T ++FE +L+ V++V++L++ Sbjct: 2475 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2534 Query: 576 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 632 +L + EA ++ E+ W+EL D + + +++ L +F + L Sbjct: 2535 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2593 Query: 633 WM 634 W+ Sbjct: 2594 WL 2595 Score = 37.7 bits (86), Expect = 0.035 Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 83/465 (17%) Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93 +W++++E +++ + +PE + ++ +L + + +E+E + SK D+ Q Sbjct: 1344 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKMDE-CQ 1392 Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGELQAQTA 150 +AE + + +LQ + A V+SQ K K + M+S + +E +L+ + Sbjct: 1393 KYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1448 Query: 151 ALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLDDELAW 206 AL L+ + G+ L RL E +E++ + +KEL + ++ L Sbjct: 1449 AL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1502 Query: 207 VQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGALASLR 261 ++ + P + Q + ++ + + Q ++ + HG ++ EE E + +L+ Sbjct: 1503 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1562 Query: 262 SPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYYFDVAE 308 L+QLQ + +E E+ Q + D Q E Sbjct: 1563 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE-------- 1614 Query: 309 VEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ESIAQLS 357 +G QE M+ + + K QS + L+K +Q L + V+N E E+ +LS Sbjct: 1615 -NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1673 Query: 358 RQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQYWLYQL 408 ++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q L + Sbjct: 1674 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ--LEES 1729 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 453 ++ L W++ V S G +H V+++ + F G Sbjct: 1730 KTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1770 Score = 35.4 bits (80), Expect = 0.17 Identities = 69/371 (18%), Positives = 144/371 (38%), Gaps = 57/371 (15%) Query: 3 MARDGTRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 56 M DGT E +L K +AE+ +N E ++ G++L QE L Sbjct: 1625 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL--- 1679 Query: 57 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 116 + +KL E + +L + ++L D++V + + + + + QL++ Sbjct: 1680 IEQKLNEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE----- 1728 Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176 + + L L +++ E + ++ Q E K +GE G L Sbjct: 1729 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----L 1784 Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236 LE D+D ++ QE L Q + + + QH Sbjct: 1785 LET-------------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH------- 1818 Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295 + + + +LE+ G S E E +++ +++L+ + L E+ ++ + Sbjct: 1819 -QAVIIATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1875 Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354 ++E++ D E E WL + E + + + G D+ + L LK+ + V +++ + Sbjct: 1876 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1935 Query: 355 QLSRQCRALLE 365 ++ +LE Sbjct: 1936 YITISGNRVLE 1946 >gi|221316618 dystonin isoform 2 [Homo sapiens] Length = 5675 Score = 97.1 bits (240), Expect = 5e-20 Identities = 136/675 (20%), Positives = 286/675 (42%), Gaps = 65/675 (9%) Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 74 L ++ H+ +A++K ++K+ + G QL++ P S+++K +++++ Sbjct: 4065 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 4124 Query: 75 TQAKARQLFEA--------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ-- 124 + +A L EA K DQ+++S + ++L S +V+ + + N Sbjct: 4125 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVS 4184 Query: 125 --LKKLQ----SMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNA---VGERLVR 175 ++KLQ +++ + EE G +A ++ ++V +N V ER + Sbjct: 4185 VDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAK 4244 Query: 176 LLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228 LL+ ++ + L++ K+ DL+D G V+Q Sbjct: 4245 LLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----------------GIDPSVVKQ 4288 Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAE 287 + + +R EI L+ V+ L A+ P+ V++ +++L SAW L +A + Sbjct: 4289 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK 4348 Query: 288 RRQQVLDAAFQVEQYYFD-VAEVEAW--LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344 R L+ A Q Y D + V W + +L MS G D ++ Q +++ Q + Sbjct: 4349 DRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKS 4407 Query: 345 GVENYEESIAQLSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQ 402 + + +L+ Q LL+ +S++ + ++ ++ +L+E R+ LE Sbjct: 4408 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4467 Query: 403 YW-LYQLSRQVSELEHWIAEKE-VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460 L Q + EL W+ E +++ +G D + + + K ++ +A + + Sbjct: 4468 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTV 4526 Query: 461 AAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAELLELMGTRAQLL-AASRELHKFFSD 518 AVN+ ++LIE A+ + K + LN+ W +LE R Q L A R+ F + Sbjct: 4527 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGE 4586 Query: 519 ARELQGQIEEKRRRL----PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA 574 +LQ + + R L P P + + AFE + S +++ Q+ Sbjct: 4587 IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML 4646 Query: 575 AQLRTVYAGEHAEAIASRE-QEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLS 632 A+ + AE ++ + + W+ + + + + + + A+ FH+ ++D ++ Sbjct: 4647 AR-----CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4701 Query: 633 WMDGIASQIGAADKP 647 W+ + A +P Sbjct: 4702 WLTQAEQTLNVASRP 4716 Score = 68.9 bits (167), Expect = 1e-11 Identities = 114/593 (19%), Positives = 241/593 (40%), Gaps = 63/593 (10%) Query: 92 VQSFAELDKKLLHMESQLQDVDPGGD-LATVNSQLKKLQSMESQVEEWYREVGELQAQT- 149 +Q + M SQ + D D +A V + LQ + ++ + +++ L A Sbjct: 3262 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3321 Query: 150 -------AALPLEPASKELVGERQN--AVGERLVRLLEPLQERRRLLLAS-KELHQVAHD 199 L E S +LVG +++ A+ ++ +LL+ Q R + + K L + Sbjct: 3322 NANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3381 Query: 200 LDDELAWVQE-------RLPLAMQTERGNGLQAV-----QQHIKKNQGLRREIQAHGPRL 247 L + +Q+ + P+ M+TE N + ++ I+ QG ++++ G L Sbjct: 3382 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3441 Query: 248 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQVEQYYFDV 306 + ++ +S + + L+ + + W L ++ A+R Q+ +A ++ + Sbjct: 3442 IQ--------SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3493 Query: 307 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESIAQLSRQCRA 362 + +W+ + E L+ ++ K + +++K +Q L++ +++ + ++ + R+ Sbjct: 3494 ESLLSWMVDTEELVANQ---KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3550 Query: 363 LLEMGHP-DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE-LEHWIA 420 + P D +I ++ S +D + AL E R LE + Q + E L W+ Sbjct: 3551 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3610 Query: 421 --EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 EK +V P Q S L+E+ ++ A + + N+ + + + G + Sbjct: 3611 TIEKRLVNCEPIGTQ----ASKLEEQIAQHK-----ALEDDIINHNKHLHQAVSIGQSLK 3661 Query: 479 AT-------MAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFS-DARELQGQIEEK 529 M + K ++ W E+ E +R++LL + K F D EL + E Sbjct: 3662 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEV 3721 Query: 530 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 589 +L +L+ Q LR + D+ L V Q +L G+ I Sbjct: 3722 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3781 Query: 590 ASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLSWMDGIASQI 641 + + + +K++ D + A R HS +L +W+D + ++ Sbjct: 3782 QDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3834 Score = 66.6 bits (161), Expect = 7e-11 Identities = 120/645 (18%), Positives = 256/645 (39%), Gaps = 51/645 (7%) Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79 LR Q L E L++ + ++Q+K E + K + ++ A+ A Sbjct: 3754 LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3813 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 R+L S ++L +++ +LL E+Q+ + +LKK + + Sbjct: 3814 RRLH--STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3871 Query: 140 REVGELQAQTAALPLEPASKELVGE---RQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 EV + +++V E R V + + + +E + +L S++ Q Sbjct: 3872 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA---ILRSQQFDQA 3928 Query: 197 AHDLDDELAWVQE---RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253 A D EL+W+ E +L + Q ++K EI H ++++++ Sbjct: 3929 A---DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT--FTMEILRHKDIIDDLVKS 3983 Query: 254 AGALASLRSPEA-EAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVAEVEA 311 + + S E +++++ L+++ + + + +ER Q+ A V Q++ E+ Sbjct: 3984 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 4043 Query: 312 WLGEQELLMMSEDKGKDEQSTL-QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 WL E + ++ E TL Q ++H QL + + ++ I ++++ LLE+ + Sbjct: 4044 WLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGE 4103 Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQ------------QYWLYQLSRQVSELEHW 418 I + D LY +KE ++R VAL++ L L R V L Sbjct: 4104 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4163 Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 + V E + ++VSV EK G E +A ++ +A Sbjct: 4164 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI------SA 4217 Query: 479 ATMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537 + + D + W + L+ R A+LL KF+ D L I++ + + L Sbjct: 4218 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLE 4277 Query: 538 TP-------PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 590 P + + +A +++ + + +L ++++ +L + + + + Sbjct: 4278 DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELN 4337 Query: 591 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635 S + + WK+ + E+A A+++ ++ + W+D Sbjct: 4338 SAWDSLNKAWKDRIDKLEEA------MQAAVQYQDGLQAVFDWVD 4376 Score = 57.8 bits (138), Expect = 3e-08 Identities = 84/361 (23%), Positives = 169/361 (46%), Gaps = 40/361 (11%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELESTTQAK 78 ++++F AEL QN +++++ + +L++E P+ + R K L EI W EL T + Sbjct: 2649 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2708 Query: 79 ARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVE 136 ++L E+S Q A+L + L+ E + + P D +N+Q +++Q + ++ Sbjct: 2709 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL---LQ 2765 Query: 137 EWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER----RR 185 E+ + + TAA P E P+ + +V E+ AV ++ L L +R + Sbjct: 2766 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2825 Query: 186 LLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243 ++ S + + L D+L+ + +L LA+ T A+ Q ++ Q +++EIQ Sbjct: 2826 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMKQEIQQE 2881 Query: 244 GPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 ++ + + E AL +AE + R LE + ++ + + AE Q L +A Sbjct: 2882 KKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2940 Query: 301 QYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ-LEQGVENYEESIAQLSR 358 + ++ + +AWL D K+EQ+ + L LE ++++++ L+ Sbjct: 2941 HQFQQMSRDFQAWL----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2990 Query: 359 Q 359 Q Sbjct: 2991 Q 2991 Score = 54.3 bits (129), Expect = 4e-07 Identities = 124/668 (18%), Positives = 248/668 (37%), Gaps = 80/668 (11%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 H+ F L EK EG+ L+ + + A+++ +L I+ W + + Sbjct: 2981 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 3040 Query: 81 QLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 +L E+ KA + + L + ++ L+++ D A + + KL+S++ ++++ + Sbjct: 3041 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 3100 Query: 140 REVGELQAQTA--ALPLEPASKELVGERQNAVGERLVRLLEPLQERR----RLLLASKEL 193 V EL TA L + KE+V + ++ +++ + E L ++ + KE Sbjct: 3101 GMV-ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEF 3159 Query: 194 HQVAHDLDDELAWVQERLP----LAMQTERGNGLQAVQQHIKKNQGLRREIQ-------- 241 +V+ + +L +E+L L Q L +Q K Q L+ ++ Sbjct: 3160 QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3219 Query: 242 -----AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296 + +VL + +A S ++ V L++ G+ +++ Sbjct: 3220 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3279 Query: 297 FQVEQYYFDVAEV--------------EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQL 342 + + +A V +A+L + E LM S D T +++ + Sbjct: 3280 AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN---KTCKMMLATEET 3336 Query: 343 EQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQ 402 + + + LS+QC LL+ EQ+ +++ Y LKE + L++ Sbjct: 3337 SPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS----ILLQK- 3391 Query: 403 YWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462 AE+ + P +G + E ++ F F E + + Sbjct: 3392 -----------------AEEHEESQGP-VGMETETINQQLNMFKVFQKEEIEPLQGKQQD 3433 Query: 463 VNQMVDELIECGHTAAAT--MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 520 VN + LI+ + +T + D +N W L + + RA L + F DA Sbjct: 3434 VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3493 Query: 521 ELQGQIEEKRRRLPRLTTPPEPR----PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576 E L PP + Q+ L+ D + V +++ E A Sbjct: 3494 ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT 3553 Query: 577 LRTVYAGEHAEAIASREQEVL--QGWKELLSACEDARLHVSS-TADALRFHSQVRDLLSW 633 E A+ + +Q L W+ LL+ E + + A +FH + L W Sbjct: 3554 -----TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3608 Query: 634 MDGIASQI 641 + I ++ Sbjct: 3609 LTTIEKRL 3616 Score = 53.9 bits (128), Expect = 5e-07 Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%) Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 362 V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A Sbjct: 786 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 845 Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422 L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK Sbjct: 846 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 896 Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482 E + + + +++ ++ +E E E + +V ++ ++L+ H A T+ Sbjct: 897 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 955 Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535 ++ + W+ +L+L Q + + +FF+DA+E + + + R Sbjct: 956 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 1008 Score = 52.0 bits (123), Expect = 2e-06 Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%) Query: 48 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 107 Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + + Sbjct: 603 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 656 Query: 108 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 153 + V G + T + + + + + G Q+ T +L Sbjct: 657 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 716 Query: 154 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + PA LV + V ++ L+ +Q R+ LL +S + Sbjct: 717 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 776 Query: 197 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 + + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E Sbjct: 777 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 836 Query: 251 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 + A L+ AE + R L+S +A L + +++ LD + + Sbjct: 837 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 889 Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369 WL E+E ++ D + + + H +L + ++ EE+I + LL HP Sbjct: 890 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 949 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 414 I E R A++ Q+ W+ QL + V + Sbjct: 950 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 977 Score = 49.7 bits (117), Expect = 9e-06 Identities = 128/682 (18%), Positives = 268/682 (39%), Gaps = 83/682 (12%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQAKA 79 +H ++ ++ +E + + G L++ E A++++ KL + Q W + T+ + Sbjct: 4511 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4570 Query: 80 RQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VNSQLKKLQSMES 133 +QL A + A +L + L E L P G L +N ++ + E+ Sbjct: 4571 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4630 Query: 134 QVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKE 192 + EE Y+ + +Q L P S E + + N + E+ + L ER+ L + Sbjct: 4631 K-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4687 Query: 193 LHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 L H+ L D + W+ Q L + + L V I +++ E+ +H ++ E Sbjct: 4688 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIE- 4746 Query: 251 LERAGA-----------------LASLRSPEAEAVRRGLE-------------QLQSAWA 280 L++ G L S++S + V+R +E Q AW+ Sbjct: 4747 LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4806 Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE----QELLMMSEDKGKDEQSTLQLL 336 L E E ++ LD+ ++ D +++ L + Q+ L T + L Sbjct: 4807 KLMEWLEESEKSLDSELEIAN---DPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4863 Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396 K+ L ++ +++L + + + RQ++++ + + + + Sbjct: 4864 KEKTSLADDNLKLDDMLSELRDKWDTI-------CGKSVERQNKLEEALLFSGQFTDALQ 4916 Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456 ++ WLY++ Q +AE + V G D + V L + F E G Sbjct: 4917 ALID---WLYRVEPQ-------LAEDQPVHG------DIDLVMNLIDNHKAFQKELGKR- 4959 Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKF 515 + A+ + ELIE ++ + L+ W + L + + +L AA R+ +F Sbjct: 4960 TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEF 5019 Query: 516 FSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575 S L + E + L P+ + ++ + F ++ L + +L + Sbjct: 5020 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATT 5076 Query: 576 QLRTVYAGEHAEAIASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LL 631 TV A H ++I + + + ++E+L+ + + ++S L ++ + LL Sbjct: 5077 MGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALL 5136 Query: 632 SWMDGIASQIGAADKPRCPSSL 653 +W+ + + DK P + Sbjct: 5137 AWLQWAETTLTDKDKEVIPQEI 5158 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%) Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 164 M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E Sbjct: 796 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 853 Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224 + + + + +LL + + R L LH +EL W+ E+ + + Sbjct: 854 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 910 Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284 + + + L RE+ ++ V E A L P + +Q+ W+ + + Sbjct: 911 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 970 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 341 + +Q + +++ D E +L + + S D+ L+++ ++ Sbjct: 971 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 1030 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 372 ++ + Y+ +IA L + + ++++ +S+ Sbjct: 1031 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 1061 Score = 40.4 bits (93), Expect = 0.005 Identities = 85/454 (18%), Positives = 178/454 (39%), Gaps = 65/454 (14%) Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95 L+++E E + L +EK E ++ Q W S T A + + + Q + S Sbjct: 1603 LKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISKTLKDAEKAGKPPFSKQKISS- 1656 Query: 96 AELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQSMESQVEEWYR-----EVGELQ 146 E+ K + LQ + GD T + + +L+ ++E Y + +LQ Sbjct: 1657 EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEKQVKTLQESYNLLFSESLKQLQ 1715 Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206 + ++ K +V ERQ E+L + + L + L+ +E + D EL Sbjct: 1716 ESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG-DGTVELKK 1773 Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----IQAHGPRLEEVLERAGALASLR 261 Q + +Q + QA+ + +K + +E Q +E+ L A Sbjct: 1774 YQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1832 Query: 262 SPEAEAVRRGLEQLQS-----------AWAGLREAAERRQQVLDAAFQVEQ--------- 301 + +AE ++ L+++ + A L E+ + + +LD V++ Sbjct: 1833 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1892 Query: 302 --------YYFDVAEVEAWLGEQE-----LLMMSEDK--GKDEQSTLQLLKKHLQLEQGV 346 +F + ++ +GE++ LL D G +++ Q +K + + Sbjct: 1893 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKI 1952 Query: 347 ENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQVDRLY-VALKELGEERRVALE 400 + +++ ++ + LLE + + E++ + ++ Y AL E ++ ++ Sbjct: 1953 ISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS 2012 Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD 434 Q L + +E EHW+ + E + E G D Sbjct: 2013 LQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 2046 Score = 40.4 bits (93), Expect = 0.005 Identities = 145/722 (20%), Positives = 282/722 (39%), Gaps = 131/722 (18%) Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 62 +D + L + R ++F ++ +K L I G +++ E A S K+ G Sbjct: 2046 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 2101 Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 120 R+ +L+ T + R L+ SK + L + +L K H E + G AT Sbjct: 2102 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2158 Query: 121 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 160 + L + ++++ Q+EE G++ +Q A+ L PA + Sbjct: 2159 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2218 Query: 161 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 218 + + VG R L + + ER +L + V LD+ L W+ L Q + Sbjct: 2219 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2277 Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 277 A+Q I KN L ++I + + E+ P A +++ ++ L + Sbjct: 2278 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2337 Query: 278 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 328 ++ EA+ + ++ L + +VE + +++ +L + + D GKD Sbjct: 2338 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2394 Query: 329 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 369 ++ST + L KKHL++ G+ + + E LS++ + + + Sbjct: 2395 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2454 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429 E ++ Q Q+D V +K L + W+ + +++V ++ G+ Sbjct: 2455 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2497 Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 487 +LG+ E LQEK+S E ++ N LI T A +A K G Sbjct: 2498 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2552 Query: 488 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 541 LN E A E L + +++ H + L+ +I E +L +L E Sbjct: 2553 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2612 Query: 542 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 575 P P+ + +T ++FE +L+ V++V++L++ Sbjct: 2613 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2672 Query: 576 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 632 +L + EA ++ E+ W+EL D + + +++ L +F + L Sbjct: 2673 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2731 Query: 633 WM 634 W+ Sbjct: 2732 WL 2733 Score = 37.7 bits (86), Expect = 0.035 Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 83/465 (17%) Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93 +W++++E +++ + +PE + ++ +L + + +E+E + SK D+ Q Sbjct: 1482 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKMDE-CQ 1530 Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGELQAQTA 150 +AE + + +LQ + A V+SQ K K + M+S + +E +L+ + Sbjct: 1531 KYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1586 Query: 151 ALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLDDELAW 206 AL L+ + G+ L RL E +E++ + +KEL + ++ L Sbjct: 1587 AL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1640 Query: 207 VQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGALASLR 261 ++ + P + Q + ++ + + Q ++ + HG ++ EE E + +L+ Sbjct: 1641 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1700 Query: 262 SPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYYFDVAE 308 L+QLQ + +E E+ Q + D Q E Sbjct: 1701 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE-------- 1752 Query: 309 VEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ESIAQLS 357 +G QE M+ + + K QS + L+K +Q L + V+N E E+ +LS Sbjct: 1753 -NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1811 Query: 358 RQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQYWLYQL 408 ++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q L + Sbjct: 1812 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ--LEES 1867 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 453 ++ L W++ V S G +H V+++ + F G Sbjct: 1868 KTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1908 Score = 35.4 bits (80), Expect = 0.17 Identities = 69/371 (18%), Positives = 144/371 (38%), Gaps = 57/371 (15%) Query: 3 MARDGTRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 56 M DGT E +L K +AE+ +N E ++ G++L QE L Sbjct: 1763 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL--- 1817 Query: 57 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 116 + +KL E + +L + ++L D++V + + + + + QL++ Sbjct: 1818 IEQKLNEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE----- 1866 Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176 + + L L +++ E + ++ Q E K +GE G L Sbjct: 1867 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----L 1922 Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236 LE D+D ++ QE L Q + + + QH Sbjct: 1923 LET-------------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH------- 1956 Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295 + + + +LE+ G S E E +++ +++L+ + L E+ ++ + Sbjct: 1957 -QAVIIATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 2013 Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354 ++E++ D E E WL + E + + + G D+ + L LK+ + V +++ + Sbjct: 2014 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 2073 Query: 355 QLSRQCRALLE 365 ++ +LE Sbjct: 2074 YITISGNRVLE 2084 >gi|34577047 dystonin isoform 1 [Homo sapiens] Length = 5497 Score = 97.1 bits (240), Expect = 5e-20 Identities = 136/675 (20%), Positives = 286/675 (42%), Gaps = 65/675 (9%) Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 74 L ++ H+ +A++K ++K+ + G QL++ P S+++K +++++ Sbjct: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946 Query: 75 TQAKARQLFEA--------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ-- 124 + +A L EA K DQ+++S + ++L S +V+ + + N Sbjct: 3947 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVS 4006 Query: 125 --LKKLQ----SMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNA---VGERLVR 175 ++KLQ +++ + EE G +A ++ ++V +N V ER + Sbjct: 4007 VDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAK 4066 Query: 176 LLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228 LL+ ++ + L++ K+ DL+D G V+Q Sbjct: 4067 LLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----------------GIDPSVVKQ 4110 Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAE 287 + + +R EI L+ V+ L A+ P+ V++ +++L SAW L +A + Sbjct: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK 4170 Query: 288 RRQQVLDAAFQVEQYYFD-VAEVEAW--LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344 R L+ A Q Y D + V W + +L MS G D ++ Q +++ Q + Sbjct: 4171 DRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKS 4229 Query: 345 GVENYEESIAQLSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQ 402 + + +L+ Q LL+ +S++ + ++ ++ +L+E R+ LE Sbjct: 4230 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4289 Query: 403 YW-LYQLSRQVSELEHWIAEKE-VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460 L Q + EL W+ E +++ +G D + + + K ++ +A + + Sbjct: 4290 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTV 4348 Query: 461 AAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAELLELMGTRAQLL-AASRELHKFFSD 518 AVN+ ++LIE A+ + K + LN+ W +LE R Q L A R+ F + Sbjct: 4349 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGE 4408 Query: 519 ARELQGQIEEKRRRL----PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA 574 +LQ + + R L P P + + AFE + S +++ Q+ Sbjct: 4409 IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML 4468 Query: 575 AQLRTVYAGEHAEAIASRE-QEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLS 632 A+ + AE ++ + + W+ + + + + + + A+ FH+ ++D ++ Sbjct: 4469 AR-----CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4523 Query: 633 WMDGIASQIGAADKP 647 W+ + A +P Sbjct: 4524 WLTQAEQTLNVASRP 4538 Score = 68.9 bits (167), Expect = 1e-11 Identities = 114/593 (19%), Positives = 241/593 (40%), Gaps = 63/593 (10%) Query: 92 VQSFAELDKKLLHMESQLQDVDPGGD-LATVNSQLKKLQSMESQVEEWYREVGELQAQT- 149 +Q + M SQ + D D +A V + LQ + ++ + +++ L A Sbjct: 3084 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3143 Query: 150 -------AALPLEPASKELVGERQN--AVGERLVRLLEPLQERRRLLLAS-KELHQVAHD 199 L E S +LVG +++ A+ ++ +LL+ Q R + + K L + Sbjct: 3144 NANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3203 Query: 200 LDDELAWVQE-------RLPLAMQTERGNGLQAV-----QQHIKKNQGLRREIQAHGPRL 247 L + +Q+ + P+ M+TE N + ++ I+ QG ++++ G L Sbjct: 3204 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3263 Query: 248 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQVEQYYFDV 306 + ++ +S + + L+ + + W L ++ A+R Q+ +A ++ + Sbjct: 3264 IQ--------SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3315 Query: 307 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESIAQLSRQCRA 362 + +W+ + E L+ ++ K + +++K +Q L++ +++ + ++ + R+ Sbjct: 3316 ESLLSWMVDTEELVANQ---KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3372 Query: 363 LLEMGHP-DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE-LEHWIA 420 + P D +I ++ S +D + AL E R LE + Q + E L W+ Sbjct: 3373 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3432 Query: 421 --EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 EK +V P Q S L+E+ ++ A + + N+ + + + G + Sbjct: 3433 TIEKRLVNCEPIGTQ----ASKLEEQIAQHK-----ALEDDIINHNKHLHQAVSIGQSLK 3483 Query: 479 AT-------MAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFS-DARELQGQIEEK 529 M + K ++ W E+ E +R++LL + K F D EL + E Sbjct: 3484 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEV 3543 Query: 530 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 589 +L +L+ Q LR + D+ L V Q +L G+ I Sbjct: 3544 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3603 Query: 590 ASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLSWMDGIASQI 641 + + + +K++ D + A R HS +L +W+D + ++ Sbjct: 3604 QDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3656 Score = 66.6 bits (161), Expect = 7e-11 Identities = 120/645 (18%), Positives = 256/645 (39%), Gaps = 51/645 (7%) Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79 LR Q L E L++ + ++Q+K E + K + ++ A+ A Sbjct: 3576 LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3635 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 R+L S ++L +++ +LL E+Q+ + +LKK + + Sbjct: 3636 RRLH--STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3693 Query: 140 REVGELQAQTAALPLEPASKELVGE---RQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 EV + +++V E R V + + + +E + +L S++ Q Sbjct: 3694 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA---ILRSQQFDQA 3750 Query: 197 AHDLDDELAWVQE---RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253 A D EL+W+ E +L + Q ++K EI H ++++++ Sbjct: 3751 A---DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT--FTMEILRHKDIIDDLVKS 3805 Query: 254 AGALASLRSPEA-EAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVAEVEA 311 + + S E +++++ L+++ + + + +ER Q+ A V Q++ E+ Sbjct: 3806 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3865 Query: 312 WLGEQELLMMSEDKGKDEQSTL-QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 WL E + ++ E TL Q ++H QL + + ++ I ++++ LLE+ + Sbjct: 3866 WLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGE 3925 Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQ------------QYWLYQLSRQVSELEHW 418 I + D LY +KE ++R VAL++ L L R V L Sbjct: 3926 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3985 Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 + V E + ++VSV EK G E +A ++ +A Sbjct: 3986 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI------SA 4039 Query: 479 ATMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537 + + D + W + L+ R A+LL KF+ D L I++ + + L Sbjct: 4040 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLE 4099 Query: 538 TP-------PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 590 P + + +A +++ + + +L ++++ +L + + + + Sbjct: 4100 DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELN 4159 Query: 591 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635 S + + WK+ + E+A A+++ ++ + W+D Sbjct: 4160 SAWDSLNKAWKDRIDKLEEA------MQAAVQYQDGLQAVFDWVD 4198 Score = 57.8 bits (138), Expect = 3e-08 Identities = 84/361 (23%), Positives = 169/361 (46%), Gaps = 40/361 (11%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELESTTQAK 78 ++++F AEL QN +++++ + +L++E P+ + R K L EI W EL T + Sbjct: 2471 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2530 Query: 79 ARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVE 136 ++L E+S Q A+L + L+ E + + P D +N+Q +++Q + ++ Sbjct: 2531 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL---LQ 2587 Query: 137 EWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER----RR 185 E+ + + TAA P E P+ + +V E+ AV ++ L L +R + Sbjct: 2588 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2647 Query: 186 LLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243 ++ S + + L D+L+ + +L LA+ T A+ Q ++ Q +++EIQ Sbjct: 2648 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMKQEIQQE 2703 Query: 244 GPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 ++ + + E AL +AE + R LE + ++ + + AE Q L +A Sbjct: 2704 KKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2762 Query: 301 QYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ-LEQGVENYEESIAQLSR 358 + ++ + +AWL D K+EQ+ + L LE ++++++ L+ Sbjct: 2763 HQFQQMSRDFQAWL----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2812 Query: 359 Q 359 Q Sbjct: 2813 Q 2813 Score = 54.3 bits (129), Expect = 4e-07 Identities = 124/668 (18%), Positives = 248/668 (37%), Gaps = 80/668 (11%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 H+ F L EK EG+ L+ + + A+++ +L I+ W + + Sbjct: 2803 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2862 Query: 81 QLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 +L E+ KA + + L + ++ L+++ D A + + KL+S++ ++++ + Sbjct: 2863 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2922 Query: 140 REVGELQAQTA--ALPLEPASKELVGERQNAVGERLVRLLEPLQERR----RLLLASKEL 193 V EL TA L + KE+V + ++ +++ + E L ++ + KE Sbjct: 2923 GMV-ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEF 2981 Query: 194 HQVAHDLDDELAWVQERLP----LAMQTERGNGLQAVQQHIKKNQGLRREIQ-------- 241 +V+ + +L +E+L L Q L +Q K Q L+ ++ Sbjct: 2982 QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 3041 Query: 242 -----AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296 + +VL + +A S ++ V L++ G+ +++ Sbjct: 3042 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3101 Query: 297 FQVEQYYFDVAEV--------------EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQL 342 + + +A V +A+L + E LM S D T +++ + Sbjct: 3102 AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN---KTCKMMLATEET 3158 Query: 343 EQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQ 402 + + + LS+QC LL+ EQ+ +++ Y LKE + L++ Sbjct: 3159 SPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS----ILLQK- 3213 Query: 403 YWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462 AE+ + P +G + E ++ F F E + + Sbjct: 3214 -----------------AEEHEESQGP-VGMETETINQQLNMFKVFQKEEIEPLQGKQQD 3255 Query: 463 VNQMVDELIECGHTAAAT--MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 520 VN + LI+ + +T + D +N W L + + RA L + F DA Sbjct: 3256 VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3315 Query: 521 ELQGQIEEKRRRLPRLTTPPEPR----PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576 E L PP + Q+ L+ D + V +++ E A Sbjct: 3316 ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT 3375 Query: 577 LRTVYAGEHAEAIASREQEVL--QGWKELLSACEDARLHVSS-TADALRFHSQVRDLLSW 633 E A+ + +Q L W+ LL+ E + + A +FH + L W Sbjct: 3376 -----TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3430 Query: 634 MDGIASQI 641 + I ++ Sbjct: 3431 LTTIEKRL 3438 Score = 53.9 bits (128), Expect = 5e-07 Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%) Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 362 V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A Sbjct: 608 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 667 Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422 L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK Sbjct: 668 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 718 Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482 E + + + +++ ++ +E E E + +V ++ ++L+ H A T+ Sbjct: 719 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 777 Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535 ++ + W+ +L+L Q + + +FF+DA+E + + + R Sbjct: 778 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 830 Score = 52.0 bits (123), Expect = 2e-06 Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%) Query: 48 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 107 Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + + Sbjct: 425 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 478 Query: 108 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 153 + V G + T + + + + + G Q+ T +L Sbjct: 479 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 538 Query: 154 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + PA LV + V ++ L+ +Q R+ LL +S + Sbjct: 539 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 598 Query: 197 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 + + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E Sbjct: 599 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 658 Query: 251 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 + A L+ AE + R L+S +A L + +++ LD + + Sbjct: 659 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 711 Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369 WL E+E ++ D + + + H +L + ++ EE+I + LL HP Sbjct: 712 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 771 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 414 I E R A++ Q+ W+ QL + V + Sbjct: 772 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 799 Score = 49.7 bits (117), Expect = 9e-06 Identities = 128/682 (18%), Positives = 268/682 (39%), Gaps = 83/682 (12%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQAKA 79 +H ++ ++ +E + + G L++ E A++++ KL + Q W + T+ + Sbjct: 4333 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4392 Query: 80 RQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VNSQLKKLQSMES 133 +QL A + A +L + L E L P G L +N ++ + E+ Sbjct: 4393 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4452 Query: 134 QVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKE 192 + EE Y+ + +Q L P S E + + N + E+ + L ER+ L + Sbjct: 4453 K-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4509 Query: 193 LHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 L H+ L D + W+ Q L + + L V I +++ E+ +H ++ E Sbjct: 4510 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIE- 4568 Query: 251 LERAGA-----------------LASLRSPEAEAVRRGLE-------------QLQSAWA 280 L++ G L S++S + V+R +E Q AW+ Sbjct: 4569 LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4628 Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE----QELLMMSEDKGKDEQSTLQLL 336 L E E ++ LD+ ++ D +++ L + Q+ L T + L Sbjct: 4629 KLMEWLEESEKSLDSELEIAN---DPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685 Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396 K+ L ++ +++L + + + RQ++++ + + + + Sbjct: 4686 KEKTSLADDNLKLDDMLSELRDKWDTI-------CGKSVERQNKLEEALLFSGQFTDALQ 4738 Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456 ++ WLY++ Q +AE + V G D + V L + F E G Sbjct: 4739 ALID---WLYRVEPQ-------LAEDQPVHG------DIDLVMNLIDNHKAFQKELGKR- 4781 Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKF 515 + A+ + ELIE ++ + L+ W + L + + +L AA R+ +F Sbjct: 4782 TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEF 4841 Query: 516 FSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575 S L + E + L P+ + ++ + F ++ L + +L + Sbjct: 4842 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATT 4898 Query: 576 QLRTVYAGEHAEAIASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LL 631 TV A H ++I + + + ++E+L+ + + ++S L ++ + LL Sbjct: 4899 MGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALL 4958 Query: 632 SWMDGIASQIGAADKPRCPSSL 653 +W+ + + DK P + Sbjct: 4959 AWLQWAETTLTDKDKEVIPQEI 4980 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%) Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 164 M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E Sbjct: 618 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 675 Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224 + + + + +LL + + R L LH +EL W+ E+ + + Sbjct: 676 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 732 Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284 + + + L RE+ ++ V E A L P + +Q+ W+ + + Sbjct: 733 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 792 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 341 + +Q + +++ D E +L + + S D+ L+++ ++ Sbjct: 793 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 852 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 372 ++ + Y+ +IA L + + ++++ +S+ Sbjct: 853 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 883 Score = 40.4 bits (93), Expect = 0.005 Identities = 85/454 (18%), Positives = 178/454 (39%), Gaps = 65/454 (14%) Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95 L+++E E + L +EK E ++ Q W S T A + + + Q + S Sbjct: 1425 LKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISKTLKDAEKAGKPPFSKQKISS- 1478 Query: 96 AELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQSMESQVEEWYR-----EVGELQ 146 E+ K + LQ + GD T + + +L+ ++E Y + +LQ Sbjct: 1479 EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEKQVKTLQESYNLLFSESLKQLQ 1537 Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206 + ++ K +V ERQ E+L + + L + L+ +E + D EL Sbjct: 1538 ESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG-DGTVELKK 1595 Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----IQAHGPRLEEVLERAGALASLR 261 Q + +Q + QA+ + +K + +E Q +E+ L A Sbjct: 1596 YQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1654 Query: 262 SPEAEAVRRGLEQLQS-----------AWAGLREAAERRQQVLDAAFQVEQ--------- 301 + +AE ++ L+++ + A L E+ + + +LD V++ Sbjct: 1655 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1714 Query: 302 --------YYFDVAEVEAWLGEQE-----LLMMSEDK--GKDEQSTLQLLKKHLQLEQGV 346 +F + ++ +GE++ LL D G +++ Q +K + + Sbjct: 1715 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKI 1774 Query: 347 ENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQVDRLY-VALKELGEERRVALE 400 + +++ ++ + LLE + + E++ + ++ Y AL E ++ ++ Sbjct: 1775 ISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS 1834 Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD 434 Q L + +E EHW+ + E + E G D Sbjct: 1835 LQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1868 Score = 40.4 bits (93), Expect = 0.005 Identities = 145/722 (20%), Positives = 282/722 (39%), Gaps = 131/722 (18%) Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 62 +D + L + R ++F ++ +K L I G +++ E A S K+ G Sbjct: 1868 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1923 Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 120 R+ +L+ T + R L+ SK + L + +L K H E + G AT Sbjct: 1924 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1980 Query: 121 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 160 + L + ++++ Q+EE G++ +Q A+ L PA + Sbjct: 1981 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2040 Query: 161 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 218 + + VG R L + + ER +L + V LD+ L W+ L Q + Sbjct: 2041 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099 Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 277 A+Q I KN L ++I + + E+ P A +++ ++ L + Sbjct: 2100 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2159 Query: 278 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 328 ++ EA+ + ++ L + +VE + +++ +L + + D GKD Sbjct: 2160 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2216 Query: 329 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 369 ++ST + L KKHL++ G+ + + E LS++ + + + Sbjct: 2217 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2276 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429 E ++ Q Q+D V +K L + W+ + +++V ++ G+ Sbjct: 2277 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2319 Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 487 +LG+ E LQEK+S E ++ N LI T A +A K G Sbjct: 2320 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2374 Query: 488 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 541 LN E A E L + +++ H + L+ +I E +L +L E Sbjct: 2375 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2434 Query: 542 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 575 P P+ + +T ++FE +L+ V++V++L++ Sbjct: 2435 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2494 Query: 576 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 632 +L + EA ++ E+ W+EL D + + +++ L +F + L Sbjct: 2495 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2553 Query: 633 WM 634 W+ Sbjct: 2554 WL 2555 Score = 37.7 bits (86), Expect = 0.035 Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 83/465 (17%) Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93 +W++++E +++ + +PE + ++ +L + + +E+E + SK D+ Q Sbjct: 1304 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKMDE-CQ 1352 Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGELQAQTA 150 +AE + + +LQ + A V+SQ K K + M+S + +E +L+ + Sbjct: 1353 KYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1408 Query: 151 ALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLDDELAW 206 AL L+ + G+ L RL E +E++ + +KEL + ++ L Sbjct: 1409 AL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1462 Query: 207 VQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGALASLR 261 ++ + P + Q + ++ + + Q ++ + HG ++ EE E + +L+ Sbjct: 1463 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1522 Query: 262 SPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYYFDVAE 308 L+QLQ + +E E+ Q + D Q E Sbjct: 1523 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE-------- 1574 Query: 309 VEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ESIAQLS 357 +G QE M+ + + K QS + L+K +Q L + V+N E E+ +LS Sbjct: 1575 -NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1633 Query: 358 RQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQYWLYQL 408 ++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q L + Sbjct: 1634 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ--LEES 1689 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 453 ++ L W++ V S G +H V+++ + F G Sbjct: 1690 KTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1730 Score = 35.4 bits (80), Expect = 0.17 Identities = 69/371 (18%), Positives = 144/371 (38%), Gaps = 57/371 (15%) Query: 3 MARDGTRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 56 M DGT E +L K +AE+ +N E ++ G++L QE L Sbjct: 1585 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL--- 1639 Query: 57 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 116 + +KL E + +L + ++L D++V + + + + + QL++ Sbjct: 1640 IEQKLNEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE----- 1688 Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176 + + L L +++ E + ++ Q E K +GE G L Sbjct: 1689 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----L 1744 Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236 LE D+D ++ QE L Q + + + QH Sbjct: 1745 LET-------------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH------- 1778 Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295 + + + +LE+ G S E E +++ +++L+ + L E+ ++ + Sbjct: 1779 -QAVIIATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1835 Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354 ++E++ D E E WL + E + + + G D+ + L LK+ + V +++ + Sbjct: 1836 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1895 Query: 355 QLSRQCRALLE 365 ++ +LE Sbjct: 1896 YITISGNRVLE 1906 >gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] Length = 5171 Score = 97.1 bits (240), Expect = 5e-20 Identities = 136/675 (20%), Positives = 286/675 (42%), Gaps = 65/675 (9%) Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 74 L ++ H+ +A++K ++K+ + G QL++ P S+++K +++++ Sbjct: 3561 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3620 Query: 75 TQAKARQLFEA--------SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ-- 124 + +A L EA K DQ+++S + ++L S +V+ + + N Sbjct: 3621 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVS 3680 Query: 125 --LKKLQ----SMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNA---VGERLVR 175 ++KLQ +++ + EE G +A ++ ++V +N V ER + Sbjct: 3681 VDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAK 3740 Query: 176 LLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQ 228 LL+ ++ + L++ K+ DL+D G V+Q Sbjct: 3741 LLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP----------------GIDPSVVKQ 3784 Query: 229 HIKKNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAE 287 + + +R EI L+ V+ L A+ P+ V++ +++L SAW L +A + Sbjct: 3785 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK 3844 Query: 288 RRQQVLDAAFQVEQYYFD-VAEVEAW--LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 344 R L+ A Q Y D + V W + +L MS G D ++ Q +++ Q + Sbjct: 3845 DRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKS 3903 Query: 345 GVENYEESIAQLSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQ 402 + + +L+ Q LL+ +S++ + ++ ++ +L+E R+ LE Sbjct: 3904 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 3963 Query: 403 YW-LYQLSRQVSELEHWIAEKE-VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERL 460 L Q + EL W+ E +++ +G D + + + K ++ +A + + Sbjct: 3964 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTV 4022 Query: 461 AAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAELLELMGTRAQLL-AASRELHKFFSD 518 AVN+ ++LIE A+ + K + LN+ W +LE R Q L A R+ F + Sbjct: 4023 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGE 4082 Query: 519 ARELQGQIEEKRRRL----PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA 574 +LQ + + R L P P + + AFE + S +++ Q+ Sbjct: 4083 IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML 4142 Query: 575 AQLRTVYAGEHAEAIASRE-QEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLS 632 A+ + AE ++ + + W+ + + + + + + A+ FH+ ++D ++ Sbjct: 4143 AR-----CPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4197 Query: 633 WMDGIASQIGAADKP 647 W+ + A +P Sbjct: 4198 WLTQAEQTLNVASRP 4212 Score = 68.9 bits (167), Expect = 1e-11 Identities = 114/593 (19%), Positives = 241/593 (40%), Gaps = 63/593 (10%) Query: 92 VQSFAELDKKLLHMESQLQDVDPGGD-LATVNSQLKKLQSMESQVEEWYREVGELQAQT- 149 +Q + M SQ + D D +A V + LQ + ++ + +++ L A Sbjct: 2758 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 2817 Query: 150 -------AALPLEPASKELVGERQN--AVGERLVRLLEPLQERRRLLLAS-KELHQVAHD 199 L E S +LVG +++ A+ ++ +LL+ Q R + + K L + Sbjct: 2818 NANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 2877 Query: 200 LDDELAWVQE-------RLPLAMQTERGNGLQAV-----QQHIKKNQGLRREIQAHGPRL 247 L + +Q+ + P+ M+TE N + ++ I+ QG ++++ G L Sbjct: 2878 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 2937 Query: 248 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQVEQYYFDV 306 + ++ +S + + L+ + + W L ++ A+R Q+ +A ++ + Sbjct: 2938 IQ--------SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 2989 Query: 307 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESIAQLSRQCRA 362 + +W+ + E L+ ++ K + +++K +Q L++ +++ + ++ + R+ Sbjct: 2990 ESLLSWMVDTEELVANQ---KPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3046 Query: 363 LLEMGHP-DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE-LEHWIA 420 + P D +I ++ S +D + AL E R LE + Q + E L W+ Sbjct: 3047 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3106 Query: 421 --EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 EK +V P Q S L+E+ ++ A + + N+ + + + G + Sbjct: 3107 TIEKRLVNCEPIGTQ----ASKLEEQIAQHK-----ALEDDIINHNKHLHQAVSIGQSLK 3157 Query: 479 AT-------MAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFS-DARELQGQIEEK 529 M + K ++ W E+ E +R++LL + K F D EL + E Sbjct: 3158 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEV 3217 Query: 530 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 589 +L +L+ Q LR + D+ L V Q +L G+ I Sbjct: 3218 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3277 Query: 590 ASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDLLSWMDGIASQI 641 + + + +K++ D + A R HS +L +W+D + ++ Sbjct: 3278 QDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3330 Score = 66.6 bits (161), Expect = 7e-11 Identities = 120/645 (18%), Positives = 256/645 (39%), Gaps = 51/645 (7%) Query: 20 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 79 LR Q L E L++ + ++Q+K E + K + ++ A+ A Sbjct: 3250 LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3309 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 R+L S ++L +++ +LL E+Q+ + +LKK + + Sbjct: 3310 RRLH--STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3367 Query: 140 REVGELQAQTAALPLEPASKELVGE---RQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 EV + +++V E R V + + + +E + +L S++ Q Sbjct: 3368 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA---ILRSQQFDQA 3424 Query: 197 AHDLDDELAWVQE---RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253 A D EL+W+ E +L + Q ++K EI H ++++++ Sbjct: 3425 A---DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKT--FTMEILRHKDIIDDLVKS 3479 Query: 254 AGALASLRSPEA-EAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVAEVEA 311 + + S E +++++ L+++ + + + +ER Q+ A V Q++ E+ Sbjct: 3480 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3539 Query: 312 WLGEQELLMMSEDKGKDEQSTL-QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 WL E + ++ E TL Q ++H QL + + ++ I ++++ LLE+ + Sbjct: 3540 WLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGE 3599 Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQ------------QYWLYQLSRQVSELEHW 418 I + D LY +KE ++R VAL++ L L R V L Sbjct: 3600 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3659 Query: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478 + V E + ++VSV EK G E +A ++ +A Sbjct: 3660 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDI------SA 3713 Query: 479 ATMAEWKDGLNEAWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537 + + D + W + L+ R A+LL KF+ D L I++ + + L Sbjct: 3714 KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLE 3773 Query: 538 TP-------PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 590 P + + +A +++ + + +L ++++ +L + + + + Sbjct: 3774 DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELN 3833 Query: 591 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMD 635 S + + WK+ + E+A A+++ ++ + W+D Sbjct: 3834 SAWDSLNKAWKDRIDKLEEA------MQAAVQYQDGLQAVFDWVD 3872 Score = 57.8 bits (138), Expect = 3e-08 Identities = 84/361 (23%), Positives = 169/361 (46%), Gaps = 40/361 (11%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELESTTQAK 78 ++++F AEL QN +++++ + +L++E P+ + R K L EI W EL T + Sbjct: 2145 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2204 Query: 79 ARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVE 136 ++L E+S Q A+L + L+ E + + P D +N+Q +++Q + ++ Sbjct: 2205 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL---LQ 2261 Query: 137 EWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER----RR 185 E+ + + TAA P E P+ + +V E+ AV ++ L L +R + Sbjct: 2262 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2321 Query: 186 LLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243 ++ S + + L D+L+ + +L LA+ T A+ Q ++ Q +++EIQ Sbjct: 2322 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMKQEIQQE 2377 Query: 244 GPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 ++ + + E AL +AE + R LE + ++ + + AE Q L +A Sbjct: 2378 KKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2436 Query: 301 QYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ-LEQGVENYEESIAQLSR 358 + ++ + +AWL D K+EQ+ + L LE ++++++ L+ Sbjct: 2437 HQFQQMSRDFQAWL----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2486 Query: 359 Q 359 Q Sbjct: 2487 Q 2487 Score = 54.3 bits (129), Expect = 4e-07 Identities = 124/668 (18%), Positives = 248/668 (37%), Gaps = 80/668 (11%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80 H+ F L EK EG+ L+ + + A+++ +L I+ W + + Sbjct: 2477 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2536 Query: 81 QLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139 +L E+ KA + + L + ++ L+++ D A + + KL+S++ ++++ + Sbjct: 2537 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2596 Query: 140 REVGELQAQTA--ALPLEPASKELVGERQNAVGERLVRLLEPLQERR----RLLLASKEL 193 V EL TA L + KE+V + ++ +++ + E L ++ + KE Sbjct: 2597 GMV-ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEF 2655 Query: 194 HQVAHDLDDELAWVQERLP----LAMQTERGNGLQAVQQHIKKNQGLRREIQ-------- 241 +V+ + +L +E+L L Q L +Q K Q L+ ++ Sbjct: 2656 QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD 2715 Query: 242 -----AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 296 + +VL + +A S ++ V L++ G+ +++ Sbjct: 2716 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 2775 Query: 297 FQVEQYYFDVAEV--------------EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQL 342 + + +A V +A+L + E LM S D T +++ + Sbjct: 2776 AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN---KTCKMMLATEET 2832 Query: 343 EQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQ 402 + + + LS+QC LL+ EQ+ +++ Y LKE + L++ Sbjct: 2833 SPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS----ILLQK- 2887 Query: 403 YWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462 AE+ + P +G + E ++ F F E + + Sbjct: 2888 -----------------AEEHEESQGP-VGMETETINQQLNMFKVFQKEEIEPLQGKQQD 2929 Query: 463 VNQMVDELIECGHTAAAT--MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 520 VN + LI+ + +T + D +N W L + + RA L + F DA Sbjct: 2930 VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 2989 Query: 521 ELQGQIEEKRRRLPRLTTPPEPR----PSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576 E L PP + Q+ L+ D + V +++ E A Sbjct: 2990 ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT 3049 Query: 577 LRTVYAGEHAEAIASREQEVL--QGWKELLSACEDARLHVSS-TADALRFHSQVRDLLSW 633 E A+ + +Q L W+ LL+ E + + A +FH + L W Sbjct: 3050 -----TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3104 Query: 634 MDGIASQI 641 + I ++ Sbjct: 3105 LTTIEKRL 3112 Score = 53.9 bits (128), Expect = 5e-07 Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%) Query: 306 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 362 V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A Sbjct: 282 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 341 Query: 363 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 422 L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK Sbjct: 342 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 392 Query: 423 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482 E + + + +++ ++ +E E E + +V ++ ++L+ H A T+ Sbjct: 393 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 451 Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535 ++ + W+ +L+L Q + + +FF+DA+E + + + R Sbjct: 452 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 504 Score = 52.0 bits (123), Expect = 2e-06 Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%) Query: 48 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 107 Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + + Sbjct: 99 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 152 Query: 108 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 153 + V G + T + + + + + G Q+ T +L Sbjct: 153 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 212 Query: 154 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + PA LV + V ++ L+ +Q R+ LL +S + Sbjct: 213 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 272 Query: 197 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 + + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E Sbjct: 273 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 332 Query: 251 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 + A L+ AE + R L+S +A L + +++ LD + + Sbjct: 333 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 385 Query: 310 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 369 WL E+E ++ D + + + H +L + ++ EE+I + LL HP Sbjct: 386 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 445 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 414 I E R A++ Q+ W+ QL + V + Sbjct: 446 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 473 Score = 49.7 bits (117), Expect = 9e-06 Identities = 128/682 (18%), Positives = 268/682 (39%), Gaps = 83/682 (12%) Query: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQAKA 79 +H ++ ++ +E + + G L++ E A++++ KL + Q W + T+ + Sbjct: 4007 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4066 Query: 80 RQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VNSQLKKLQSMES 133 +QL A + A +L + L E L P G L +N ++ + E+ Sbjct: 4067 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4126 Query: 134 QVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKE 192 + EE Y+ + +Q L P S E + + N + E+ + L ER+ L + Sbjct: 4127 K-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4183 Query: 193 LHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 L H+ L D + W+ Q L + + L V I +++ E+ +H ++ E Sbjct: 4184 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIE- 4242 Query: 251 LERAGA-----------------LASLRSPEAEAVRRGLE-------------QLQSAWA 280 L++ G L S++S + V+R +E Q AW+ Sbjct: 4243 LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4302 Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE----QELLMMSEDKGKDEQSTLQLL 336 L E E ++ LD+ ++ D +++ L + Q+ L T + L Sbjct: 4303 KLMEWLEESEKSLDSELEIAN---DPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4359 Query: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396 K+ L ++ +++L + + + RQ++++ + + + + Sbjct: 4360 KEKTSLADDNLKLDDMLSELRDKWDTI-------CGKSVERQNKLEEALLFSGQFTDALQ 4412 Query: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456 ++ WLY++ Q +AE + V G D + V L + F E G Sbjct: 4413 ALID---WLYRVEPQ-------LAEDQPVHG------DIDLVMNLIDNHKAFQKELGKR- 4455 Query: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKF 515 + A+ + ELIE ++ + L+ W + L + + +L AA R+ +F Sbjct: 4456 TSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEF 4515 Query: 516 FSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575 S L + E + L P+ + ++ + F ++ L + +L + Sbjct: 4516 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATT 4572 Query: 576 QLRTVYAGEHAEAIASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LL 631 TV A H ++I + + + ++E+L+ + + ++S L ++ + LL Sbjct: 4573 MGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALL 4632 Query: 632 SWMDGIASQIGAADKPRCPSSL 653 +W+ + + DK P + Sbjct: 4633 AWLQWAETTLTDKDKEVIPQEI 4654 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%) Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 164 M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E Sbjct: 292 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 349 Query: 165 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 224 + + + + +LL + + R L LH +EL W+ E+ + + Sbjct: 350 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 406 Query: 225 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 284 + + + L RE+ ++ V E A L P + +Q+ W+ + + Sbjct: 407 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 466 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 341 + +Q + +++ D E +L + + S D+ L+++ ++ Sbjct: 467 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 372 ++ + Y+ +IA L + + ++++ +S+ Sbjct: 527 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 557 Score = 40.4 bits (93), Expect = 0.005 Identities = 85/454 (18%), Positives = 178/454 (39%), Gaps = 65/454 (14%) Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95 L+++E E + L +EK E ++ Q W S T A + + + Q + S Sbjct: 1099 LKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISKTLKDAEKAGKPPFSKQKISS- 1152 Query: 96 AELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQSMESQVEEWYR-----EVGELQ 146 E+ K + LQ + GD T + + +L+ ++E Y + +LQ Sbjct: 1153 EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEKQVKTLQESYNLLFSESLKQLQ 1211 Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206 + ++ K +V ERQ E+L + + L + L+ +E + D EL Sbjct: 1212 ESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG-DGTVELKK 1269 Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----IQAHGPRLEEVLERAGALASLR 261 Q + +Q + QA+ + +K + +E Q +E+ L A Sbjct: 1270 YQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1328 Query: 262 SPEAEAVRRGLEQLQS-----------AWAGLREAAERRQQVLDAAFQVEQ--------- 301 + +AE ++ L+++ + A L E+ + + +LD V++ Sbjct: 1329 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1388 Query: 302 --------YYFDVAEVEAWLGEQE-----LLMMSEDK--GKDEQSTLQLLKKHLQLEQGV 346 +F + ++ +GE++ LL D G +++ Q +K + + Sbjct: 1389 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKI 1448 Query: 347 ENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQVDRLY-VALKELGEERRVALE 400 + +++ ++ + LLE + + E++ + ++ Y AL E ++ ++ Sbjct: 1449 ISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS 1508 Query: 401 QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQD 434 Q L + +E EHW+ + E + E G D Sbjct: 1509 LQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1542 Score = 40.4 bits (93), Expect = 0.005 Identities = 145/722 (20%), Positives = 282/722 (39%), Gaps = 131/722 (18%) Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 62 +D + L + R ++F ++ +K L I G +++ E A S K+ G Sbjct: 1542 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1597 Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 120 R+ +L+ T + R L+ SK + L + +L K H E + G AT Sbjct: 1598 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1654 Query: 121 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 160 + L + ++++ Q+EE G++ +Q A+ L PA + Sbjct: 1655 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 1714 Query: 161 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 218 + + VG R L + + ER +L + V LD+ L W+ L Q + Sbjct: 1715 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 1773 Query: 219 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 277 A+Q I KN L ++I + + E+ P A +++ ++ L + Sbjct: 1774 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 1833 Query: 278 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 328 ++ EA+ + ++ L + +VE + +++ +L + + D GKD Sbjct: 1834 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 1890 Query: 329 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 369 ++ST + L KKHL++ G+ + + E LS++ + + + Sbjct: 1891 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 1950 Query: 370 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 429 E ++ Q Q+D V +K L + W+ + +++V ++ G+ Sbjct: 1951 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 1993 Query: 430 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 487 +LG+ E LQEK+S E ++ N LI T A +A K G Sbjct: 1994 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2048 Query: 488 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 541 LN E A E L + +++ H + L+ +I E +L +L E Sbjct: 2049 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2108 Query: 542 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 575 P P+ + +T ++FE +L+ V++V++L++ Sbjct: 2109 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2168 Query: 576 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 632 +L + EA ++ E+ W+EL D + + +++ L +F + L Sbjct: 2169 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2227 Query: 633 WM 634 W+ Sbjct: 2228 WL 2229 Score = 37.7 bits (86), Expect = 0.035 Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 83/465 (17%) Query: 34 EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ 93 +W++++E +++ + +PE + ++ +L + + +E+E + SK D+ Q Sbjct: 978 DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKMDE-CQ 1026 Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGELQAQTA 150 +AE + + +LQ + A V+SQ K K + M+S + +E +L+ + Sbjct: 1027 KYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1082 Query: 151 ALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLDDELAW 206 AL L+ + G+ L RL E +E++ + +KEL + ++ L Sbjct: 1083 AL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1136 Query: 207 VQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGALASLR 261 ++ + P + Q + ++ + + Q ++ + HG ++ EE E + +L+ Sbjct: 1137 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1196 Query: 262 SPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYYFDVAE 308 L+QLQ + +E E+ Q + D Q E Sbjct: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE-------- 1248 Query: 309 VEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ESIAQLS 357 +G QE M+ + + K QS + L+K +Q L + V+N E E+ +LS Sbjct: 1249 -NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1307 Query: 358 RQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQYWLYQL 408 ++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q L + Sbjct: 1308 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ--LEES 1363 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 453 ++ L W++ V S G +H V+++ + F G Sbjct: 1364 KTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1404 Score = 35.4 bits (80), Expect = 0.17 Identities = 69/371 (18%), Positives = 144/371 (38%), Gaps = 57/371 (15%) Query: 3 MARDGTRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 56 M DGT E +L K +AE+ +N E ++ G++L QE L Sbjct: 1259 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL--- 1313 Query: 57 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 116 + +KL E + +L + ++L D++V + + + + + QL++ Sbjct: 1314 IEQKLNEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE----- 1362 Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176 + + L L +++ E + ++ Q E K +GE G L Sbjct: 1363 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----L 1418 Query: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 236 LE D+D ++ QE L Q + + + QH Sbjct: 1419 LET-------------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH------- 1452 Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295 + + + +LE+ G S E E +++ +++L+ + L E+ ++ + Sbjct: 1453 -QAVIIATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1509 Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354 ++E++ D E E WL + E + + + G D+ + L LK+ + V +++ + Sbjct: 1510 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1569 Query: 355 QLSRQCRALLE 365 ++ +LE Sbjct: 1570 YITISGNRVLE 1580 >gi|33188443 microfilament and actin filament cross-linker protein isoform b [Homo sapiens] Length = 5938 Score = 84.0 bits (206), Expect = 4e-16 Identities = 139/688 (20%), Positives = 282/688 (40%), Gaps = 87/688 (12%) Query: 25 FMAELAQNKEWLEKIER---EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81 F +L Q+++ ++ + + E Q+ ++E+ + A+S +++L E R+ L T Q ++ Sbjct: 2725 FALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRK----LVRTFQKWLKE 2780 Query: 82 LFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYRE 141 + + S EL+K++ H++S L D G L ++++ + +E E Sbjct: 2781 TEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL------VEEINCKGTSLENLIME 2834 Query: 142 VGELQAQTAALPLEPASKELVGERQ------------------NAVGERLVRLLEPLQER 183 + +Q + P+ VG N E+L +L QE Sbjct: 2835 ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQES 2894 Query: 184 RRLLL-ASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQA 242 + +L +E+H+ A+ + L +E L + V+ + N+ E++ Sbjct: 2895 LQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQ 2954 Query: 243 HGPRLEEVLER-AGALASL-RSPEAEAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQV 299 + P++++V E AG L + S EAE ++ E+L S W E RQ Q+ ++A + Sbjct: 2955 NSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHL 3014 Query: 300 EQYYFDVAEVEAWLGEQELLM-----MSEDK---GKDEQSTLQLLK-------KHLQLEQ 344 + +++ WL E+EL+M +S D +Q +LK +H QL + Sbjct: 3015 ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074 Query: 345 -------GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRV 397 G + S +Q+ ++ +++ + +++++ R SQ+D+ V Sbjct: 3075 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK---------- 3124 Query: 398 ALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE-LGQDFEHVSVLQEKFSEFASETGMAG 456 + + Q L LS +V + ++ + ++ PE + Q E S ++ + E A Sbjct: 3125 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQ 3184 Query: 457 R-----ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511 L + DEL + T A + +D + L + + Q E Sbjct: 3185 TLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDE 3244 Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571 L + D + Q + +L RL + + Q++L +++V+ Sbjct: 3245 LRTWLDDKQSQQAKNCPISAKLERLQSQLQEN---EEFQKSLNQHSGSYEVIVA------ 3295 Query: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDL 630 EG + L +V GE + ++ E+ W+EL D + + A ++ V DL Sbjct: 3296 EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDL 3355 Query: 631 LSWMDGIASQIG----AADKPRCPSSLL 654 + W++ +++ D + SSLL Sbjct: 3356 VPWIEDCKAKMSELRVTLDPVQLESSLL 3383 Score = 81.3 bits (199), Expect = 3e-15 Identities = 128/683 (18%), Positives = 272/683 (39%), Gaps = 69/683 (10%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70 D+ +L ++ + +A++K ++K+ + G QL + PE V +K + +A+ Sbjct: 4356 DHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ 4415 Query: 71 LESTTQAKARQLFEA-SKADQLVQSFAELDKKLLHME---SQLQ-------DVDPGGDLA 119 ++ + +A L EA S++ Q+ + +++ L +E S+L+ +VD + Sbjct: 4416 IKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECI 4475 Query: 120 TVN-SQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAV--------- 169 + N S +L+ ++ E R EL ++ + A+KE+ + V Sbjct: 4476 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4535 Query: 170 -GERLVRLLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGN 221 ER ++ L+ L+ + LL K+ + HDL+ G Sbjct: 4536 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP----------------GI 4579 Query: 222 GLQAVQQHIKKNQGLRREIQAHGPRLEEV-LERAGALASLRSPEAEAVRRGLEQLQSAWA 280 ++Q ++ + ++ E LE + + A + + E VR+ ++++ +AW Sbjct: 4580 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4639 Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQEL-LMMSEDKGKDEQSTLQLLKK 338 L + + R + L+ A Q Y D + + WL + L G D + L + Sbjct: 4640 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4699 Query: 339 HLQLEQGVENYEESIAQLSRQCRALLEMG--HPDSEQISRRQSQVDRLYVALKELGEERR 396 + + V + + +L+ Q +L+ D + I +++ L+ L E R+ Sbjct: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759 Query: 397 VALEQQYW-LYQLSRQVSELEHWIAE-KEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454 LE L Q + EL W+ +E++ + D + + V K ++ + Sbjct: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV-L 4818 Query: 455 AGRERLAAVNQMVDELIE-CGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELH 513 A + + VN+ +EL+E A+++ + +N+ W +L+ R Q +L Sbjct: 4819 AHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ------QLQ 4872 Query: 514 KFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEG 573 A+ +IE+ L R+ + + T R L SQ++ +E Sbjct: 4873 STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEET 4932 Query: 574 AAQL----RTVYAGEHAEAIASREQEVL----QGWKELLSACEDARLHVSSTAD-ALRFH 624 QL R + S+ ++ + Q W + S E+ + + + A F Sbjct: 4933 YNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQ 4992 Query: 625 SQVRDLLSWMDGIASQIGAADKP 647 + +++ ++W+ + A P Sbjct: 4993 NSLQEFINWLTLAEQSLNIASPP 5015 Score = 80.9 bits (198), Expect = 4e-15 Identities = 134/656 (20%), Positives = 277/656 (42%), Gaps = 54/656 (8%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKP--ELAASVRKKLGEIRQCWAELESTTQAKA 79 ++AF+AEL QN ++K++ L+ P + A + +K E+ W T A+ Sbjct: 2945 NKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQ 3004 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQ-------DVDPGGDLATVNSQLKKLQSME 132 RQL E++ Q+ AE + ME +L +DP +N+Q +++Q M Sbjct: 3005 RQLEESASHLACFQA-AESQLRPWLMEKELMMGVLGPLSIDPN----MLNAQKQQVQFML 3059 Query: 133 SQVEEWYREVGELQAQTAALPLEPASKEL----VGERQNAVGERLVRLLEPLQERR---- 184 + E ++ +L + P L V + ++ ++ V L + L R Sbjct: 3060 KEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQID 3119 Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244 + ++ S + ++ DL +++ V +R L++Q+ +AV+Q +++ +R +++ Sbjct: 3120 QAIVKSTQYQELLQDLSEKVRAVGQR--LSVQSAISTQPEAVKQQLEETSEIRSDLEQLD 3177 Query: 245 PRLEEVLERAGALASLRSPE--AEAVRRGLEQLQSAWAGLRE-AAERRQQVLDAAFQVEQ 301 ++E L+ L + + +++ LE + GL + AA+R ++ A +Q Sbjct: 3178 HEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 3237 Query: 302 YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCR 361 + E+ WL +++ + K+ + +L + QL++ E +++S+ Q S Sbjct: 3238 FQQMFDELRTWLDDKQ-----SQQAKNCPISAKLERLQSQLQEN-EEFQKSLNQHSGSYE 3291 Query: 362 ALLEMGH------PDSEQISRRQSQVDRLYVALKELGE---ERRVALE---QQYWLYQLS 409 ++ G P E+ Q+Q+ L +EL + +R+ L+ Q+ YQ Sbjct: 3292 VIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW- 3350 Query: 410 RQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAV-NQMVD 468 V +L WI ++ A EL + V + A + R L + N D Sbjct: 3351 -HVEDLVPWI--EDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 3407 Query: 469 ELIECGHTAAATMAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527 LI + + K G+N+ A EL L ++ L +F + ++ ++E Sbjct: 3408 ILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVE 3467 Query: 528 EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL-RTVYAGEHA 586 + +L S ++++ LRA + LQ L QV L+ L G A Sbjct: 3468 GAKHQLEIFDALGSQACSNKNLEK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDA 3526 Query: 587 EAIASREQEVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLSWMDGIASQI 641 + + + Q + E+ + + + + + +FH +VR++ S + + ++ Sbjct: 3527 SQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDEL 3582 Score = 69.3 bits (168), Expect = 1e-11 Identities = 132/666 (19%), Positives = 268/666 (40%), Gaps = 50/666 (7%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70 D +L LR +A + E+ + + LE + L+ +R + I Q Sbjct: 3374 DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDA 3433 Query: 71 LESTTQAKARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 129 + QAK L E + + + +SF ++KK+ + QL+ D G A N L+KL+ Sbjct: 3434 VTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLR 3493 Query: 130 SMESQVEEWYREVGELQAQTAAL---------------PLEPASKELVGERQNAVGERLV 174 + + ++ +V L+ T L E A +E + +Q V V Sbjct: 3494 AQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQR-VNSGCV 3552 Query: 175 RLLEPLQERRRLLLASKELHQVAHDLDDELAWVQE--RLPLAMQTERGNGLQAVQQHIKK 232 + L+ + +E+ DLDDEL + R ++Q++ ++ V+ + K Sbjct: 3553 MMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ----IEDVRLFLNK 3608 Query: 233 NQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQV 292 L+ +I+A +LE G L L ++R LE L L E + RQ+ Sbjct: 3609 IHVLKLDIEASEAECRHMLEEEGTLDLL------GLKRELEALNKQCGKLTERGKARQEQ 3662 Query: 293 LDAAF-QVEQYYFDVAEV-EAWLGEQELLMMSEDKGKDEQSTLQLLK--KHLQLEQGVEN 348 L+ +VE +Y + + +A +E + G + + Q L K Q EQ V+ Sbjct: 3663 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQ-VDP 3721 Query: 349 YEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLY 406 + + Q++ + L++ D + + + ++ + L ++ +R+A Q+ L+ Sbjct: 3722 LQMKLQQVNGLGQGLIQSAGKDCD-VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3780 Query: 407 --QLSRQVSELEHWIAE-KEVVAGSPELGQDFEHV--SVLQEKFSEFASETGMAGRERLA 461 + + L W+A+ +E++A +++ V + ++K + + A + L Sbjct: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840 Query: 462 AVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARE 521 A + + E T + L W ELL R + L L K F + E Sbjct: 3841 AEGGRIAQSAELADREKIT--GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAE 3898 Query: 522 -LQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR--AFEHDLQLLVSQVRQLQEGAAQLR 578 + + ++L + P +A Q+ +R A E D++ + V Q + L Sbjct: 3899 PISDFLSVTEKKL--ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLS 3956 Query: 579 TVYAGEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTADALRFHSQVRDLLSWMDGI 637 ++ + ++ + + + E+ C A L + ++A F ++L+W+ + Sbjct: 3957 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEV 4016 Query: 638 ASQIGA 643 ++ + Sbjct: 4017 EDKLSS 4022 Score = 63.2 bits (152), Expect = 8e-10 Identities = 81/401 (20%), Positives = 171/401 (42%), Gaps = 18/401 (4%) Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELES 73 LH++ H A E+ K+ +++ + GQ L+ Q E +++KL I+ +A++ Sbjct: 4033 LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITV 4092 Query: 74 TTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSME 132 T+ R L +A + A + ++ EL L +E +L G + Q+ + Q + Sbjct: 4093 TSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA---TSGGQSPTGEQIPQFQQRQ 4149 Query: 133 SQVEEWYREVGEL-----QAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQER-RR 185 ++++ E + + A L L P ++E + + + E+ + + + +R Sbjct: 4150 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 4209 Query: 186 LLLASKELHQVAHDLDDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243 + A + Q D ELAWV E R +A+ R Q Q ++ + +I H Sbjct: 4210 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ-LQVQKAFSIDIIRH 4268 Query: 244 GPRLEEVLERAGALASLRSPEAEAV-RRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQ 301 ++E+ + E + V + E L + + +ER ++ A V Q Sbjct: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328 Query: 302 YYFDVAEVEAWLGE-QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 ++ E+ W+ E + L+ D + Q ++ QL + + ++ I +L + Sbjct: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 4388 Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401 L E+ + E + + + + +Y +KE +R +AL++ Sbjct: 4389 PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDE 4429 Score = 57.0 bits (136), Expect = 6e-08 Identities = 103/558 (18%), Positives = 227/558 (40%), Gaps = 54/558 (9%) Query: 39 IEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFE-ASKADQLVQSFAE 97 +++ G L E+ ++ +++KLGE+++ ++ + ++A+ +Q+ + + +Q E Sbjct: 2272 LDQHGHNLTPEEQQM---LQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 2328 Query: 98 LDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA----LP 153 + L E +L+++ GG L K Q S E+ G+L+ T + L Sbjct: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS--EDVISHKGDLRFVTISGQKVLD 2386 Query: 154 LEPASKELVGERQNAVGERLVRLLEPLQER------------RRLLLASKELHQVAHDLD 201 +E + KE G+ + +G + L+ ER L + + HQ + D Sbjct: 2387 MENSFKE--GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSAD 2444 Query: 202 DELAWVQ---ERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258 AW+Q + + + +Q+ + + L+ E+ H +E++ + A + Sbjct: 2445 SLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIM 2504 Query: 259 SLR---SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF-QVEQYYFDVAEVEAWLG 314 + +P+ V+ + + S + L + R +L A Q + + + +G Sbjct: 2505 EIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIG 2564 Query: 315 EQELLMMSEDKGKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373 E E + + +Q L +++L+Q + + S+ +E + Sbjct: 2565 EVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA 2624 Query: 374 ISR-RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVS-ELEHWIAEK-EVVAGSPE 430 + + + ++V + + L +E+ +L++ ++ +S +L+ ++ K ++A + Sbjct: 2625 VLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ 2684 Query: 431 LGQDFEH-VSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489 QD H +QE E + +E L + +V EL CG A + + +D + Sbjct: 2685 PDQDITHFFQQIQELNLEMEDQ-----QENLDTLEHLVTELSSCGF--ALDLCQHQDRVQ 2737 Query: 490 EAWAELLELMGT----RAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS 545 + EL T + +L +F R Q ++E +P P E S Sbjct: 2738 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIP----PTETSMS 2793 Query: 546 ASSMQRTLRAFEHDLQLL 563 A +++ + EH LL Sbjct: 2794 AKELEKQI---EHLKSLL 2808 Score = 47.8 bits (112), Expect = 3e-05 Identities = 91/492 (18%), Positives = 193/492 (39%), Gaps = 20/492 (4%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVR--KKLGEIRQCWAELESTTQAKA 79 H ++L +E ++ +G+ ++ + + + + + + + Q W + S + + Sbjct: 4919 HMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4978 Query: 80 RQLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGG-DLATVNSQLKKLQSMESQVEE 137 +L EA + A + S E L E L P L TV SQ+++ + ++V Sbjct: 4979 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 5038 Query: 138 WYREVGELQAQTAALPLEPASKE--LVGERQNAVGERLVRLLEPLQERRRLL----LASK 191 ++ EL L ++ L+ +V R ++++ ER R L +K Sbjct: 5039 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 5098 Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVL 251 + H+ L D L + L + E N ++ + K++ ++ + P + + Sbjct: 5099 QFHEAWKKLIDWLEDAESHLD--SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 5156 Query: 252 ERAGALA--SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 AL +L +++ + L +++ W + + RQ L+ A + D + Sbjct: 5157 RTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQA 5216 Query: 310 EA-WLGEQELLMMSEDKGK--DEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEM 366 WL + E ++ED+ D + L+ H ++ + ++ L R R L+E Sbjct: 5217 LVDWLYKVEP-QLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN 5275 Query: 367 GHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQ-VSELEHWIAEKE-V 424 D+ + + ++ + + +L ++ LEQ ++ R V L W++E E Sbjct: 5276 SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQT 5335 Query: 425 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEW 484 + L D E + L + EF + + +AV L C T+ W Sbjct: 5336 LRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 5395 Query: 485 KDGLNEAWAELL 496 + + E+L Sbjct: 5396 ITIIRARFEEVL 5407 Score = 32.3 bits (72), Expect = 1.5 Identities = 71/395 (17%), Positives = 154/395 (38%), Gaps = 58/395 (14%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK--PELAASVRKKLGEIRQCW 68 D K+ + +H+ F L + + R G+ L ++ PE + + LGE+R W Sbjct: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 5186 Query: 69 AELESTTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK 127 + + + +L EA + Q + + L L +E QL + P V+ L Sbjct: 5187 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQP------VHGDLDL 5240 Query: 128 LQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE--------- 178 + ++ + + +E+G+ L + + +EL+ ++ +L E Sbjct: 5241 VMNLMDAHKVFQKELGKRTGTVQVL--KRSGRELIENSRDDTTWVKGQLQELSTRWDTVC 5298 Query: 179 --PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL-----QAVQQHIK 231 + ++ RL A K+ + L W+ E A QT R G +A+Q I Sbjct: 5299 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSE----AEQTLRFRGALPDDTEALQSLID 5354 Query: 232 KNQGLRREIQAHGPRLEEVLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQ 290 ++ ++++ + + + ++ P+ ++ + +++ + + A++ Q Sbjct: 5355 THKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQ 5414 Query: 291 QVLDAAFQVEQYYFDVAE-VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349 Q L+ A ++ E + AW+ E ++ D Sbjct: 5415 QRLETALSELVANAELLEELLAWIQWAETTLIQRD------------------------- 5449 Query: 350 EESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 384 +E I Q + +AL+ E+++R+Q VDR+ Sbjct: 5450 QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 5484 >gi|33188445 microfilament and actin filament cross-linker protein isoform a [Homo sapiens] Length = 5430 Score = 84.0 bits (206), Expect = 4e-16 Identities = 139/688 (20%), Positives = 282/688 (40%), Gaps = 87/688 (12%) Query: 25 FMAELAQNKEWLEKIER---EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81 F +L Q+++ ++ + + E Q+ ++E+ + A+S +++L E R+ L T Q ++ Sbjct: 2223 FALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRK----LVRTFQKWLKE 2278 Query: 82 LFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYRE 141 + + S EL+K++ H++S L D G L ++++ + +E E Sbjct: 2279 TEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL------VEEINCKGTSLENLIME 2332 Query: 142 VGELQAQTAALPLEPASKELVGERQ------------------NAVGERLVRLLEPLQER 183 + +Q + P+ VG N E+L +L QE Sbjct: 2333 ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQES 2392 Query: 184 RRLLL-ASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQA 242 + +L +E+H+ A+ + L +E L + V+ + N+ E++ Sbjct: 2393 LQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQ 2452 Query: 243 HGPRLEEVLER-AGALASL-RSPEAEAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQV 299 + P++++V E AG L + S EAE ++ E+L S W E RQ Q+ ++A + Sbjct: 2453 NSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHL 2512 Query: 300 EQYYFDVAEVEAWLGEQELLM-----MSEDK---GKDEQSTLQLLK-------KHLQLEQ 344 + +++ WL E+EL+M +S D +Q +LK +H QL + Sbjct: 2513 ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 2572 Query: 345 -------GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRV 397 G + S +Q+ ++ +++ + +++++ R SQ+D+ V Sbjct: 2573 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK---------- 2622 Query: 398 ALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE-LGQDFEHVSVLQEKFSEFASETGMAG 456 + + Q L LS +V + ++ + ++ PE + Q E S ++ + E A Sbjct: 2623 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQ 2682 Query: 457 R-----ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511 L + DEL + T A + +D + L + + Q E Sbjct: 2683 TLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDE 2742 Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571 L + D + Q + +L RL + + Q++L +++V+ Sbjct: 2743 LRTWLDDKQSQQAKNCPISAKLERLQSQLQEN---EEFQKSLNQHSGSYEVIVA------ 2793 Query: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTAD-ALRFHSQVRDL 630 EG + L +V GE + ++ E+ W+EL D + + A ++ V DL Sbjct: 2794 EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDL 2853 Query: 631 LSWMDGIASQIG----AADKPRCPSSLL 654 + W++ +++ D + SSLL Sbjct: 2854 VPWIEDCKAKMSELRVTLDPVQLESSLL 2881 Score = 81.3 bits (199), Expect = 3e-15 Identities = 128/683 (18%), Positives = 272/683 (39%), Gaps = 69/683 (10%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70 D+ +L ++ + +A++K ++K+ + G QL + PE V +K + +A+ Sbjct: 3854 DHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ 3913 Query: 71 LESTTQAKARQLFEA-SKADQLVQSFAELDKKLLHME---SQLQ-------DVDPGGDLA 119 ++ + +A L EA S++ Q+ + +++ L +E S+L+ +VD + Sbjct: 3914 IKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECI 3973 Query: 120 TVN-SQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAV--------- 169 + N S +L+ ++ E R EL ++ + A+KE+ + V Sbjct: 3974 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4033 Query: 170 -GERLVRLLEPLQ-------ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGN 221 ER ++ L+ L+ + LL K+ + HDL+ G Sbjct: 4034 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP----------------GI 4077 Query: 222 GLQAVQQHIKKNQGLRREIQAHGPRLEEV-LERAGALASLRSPEAEAVRRGLEQLQSAWA 280 ++Q ++ + ++ E LE + + A + + E VR+ ++++ +AW Sbjct: 4078 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4137 Query: 281 GLREAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQEL-LMMSEDKGKDEQSTLQLLKK 338 L + + R + L+ A Q Y D + + WL + L G D + L + Sbjct: 4138 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4197 Query: 339 HLQLEQGVENYEESIAQLSRQCRALLEMG--HPDSEQISRRQSQVDRLYVALKELGEERR 396 + + V + + +L+ Q +L+ D + I +++ L+ L E R+ Sbjct: 4198 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4257 Query: 397 VALEQQYW-LYQLSRQVSELEHWIAE-KEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454 LE L Q + EL W+ +E++ + D + + V K ++ + Sbjct: 4258 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV-L 4316 Query: 455 AGRERLAAVNQMVDELIE-CGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELH 513 A + + VN+ +EL+E A+++ + +N+ W +L+ R Q +L Sbjct: 4317 AHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ------QLQ 4370 Query: 514 KFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEG 573 A+ +IE+ L R+ + + T R L SQ++ +E Sbjct: 4371 STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEET 4430 Query: 574 AAQL----RTVYAGEHAEAIASREQEVL----QGWKELLSACEDARLHVSSTAD-ALRFH 624 QL R + S+ ++ + Q W + S E+ + + + A F Sbjct: 4431 YNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQ 4490 Query: 625 SQVRDLLSWMDGIASQIGAADKP 647 + +++ ++W+ + A P Sbjct: 4491 NSLQEFINWLTLAEQSLNIASPP 4513 Score = 80.9 bits (198), Expect = 4e-15 Identities = 134/656 (20%), Positives = 277/656 (42%), Gaps = 54/656 (8%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKP--ELAASVRKKLGEIRQCWAELESTTQAKA 79 ++AF+AEL QN ++K++ L+ P + A + +K E+ W T A+ Sbjct: 2443 NKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQ 2502 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQ-------DVDPGGDLATVNSQLKKLQSME 132 RQL E++ Q+ AE + ME +L +DP +N+Q +++Q M Sbjct: 2503 RQLEESASHLACFQA-AESQLRPWLMEKELMMGVLGPLSIDPN----MLNAQKQQVQFML 2557 Query: 133 SQVEEWYREVGELQAQTAALPLEPASKEL----VGERQNAVGERLVRLLEPLQERR---- 184 + E ++ +L + P L V + ++ ++ V L + L R Sbjct: 2558 KEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQID 2617 Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHG 244 + ++ S + ++ DL +++ V +R L++Q+ +AV+Q +++ +R +++ Sbjct: 2618 QAIVKSTQYQELLQDLSEKVRAVGQR--LSVQSAISTQPEAVKQQLEETSEIRSDLEQLD 2675 Query: 245 PRLEEVLERAGALASLRSPE--AEAVRRGLEQLQSAWAGLRE-AAERRQQVLDAAFQVEQ 301 ++E L+ L + + +++ LE + GL + AA+R ++ A +Q Sbjct: 2676 HEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 2735 Query: 302 YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCR 361 + E+ WL +++ + K+ + +L + QL++ E +++S+ Q S Sbjct: 2736 FQQMFDELRTWLDDKQ-----SQQAKNCPISAKLERLQSQLQEN-EEFQKSLNQHSGSYE 2789 Query: 362 ALLEMGH------PDSEQISRRQSQVDRLYVALKELGE---ERRVALE---QQYWLYQLS 409 ++ G P E+ Q+Q+ L +EL + +R+ L+ Q+ YQ Sbjct: 2790 VIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW- 2848 Query: 410 RQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAV-NQMVD 468 V +L WI ++ A EL + V + A + R L + N D Sbjct: 2849 -HVEDLVPWI--EDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 2905 Query: 469 ELIECGHTAAATMAEWKDGLNEAW-AELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527 LI + + K G+N+ A EL L ++ L +F + ++ ++E Sbjct: 2906 ILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVE 2965 Query: 528 EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL-RTVYAGEHA 586 + +L S ++++ LRA + LQ L QV L+ L G A Sbjct: 2966 GAKHQLEIFDALGSQACSNKNLEK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDA 3024 Query: 587 EAIASREQEVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLSWMDGIASQI 641 + + + Q + E+ + + + + + +FH +VR++ S + + ++ Sbjct: 3025 SQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDEL 3080 Score = 69.3 bits (168), Expect = 1e-11 Identities = 132/666 (19%), Positives = 268/666 (40%), Gaps = 50/666 (7%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 70 D +L LR +A + E+ + + LE + L+ +R + I Q Sbjct: 2872 DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDA 2931 Query: 71 LESTTQAKARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 129 + QAK L E + + + +SF ++KK+ + QL+ D G A N L+KL+ Sbjct: 2932 VTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLR 2991 Query: 130 SMESQVEEWYREVGELQAQTAAL---------------PLEPASKELVGERQNAVGERLV 174 + + ++ +V L+ T L E A +E + +Q V V Sbjct: 2992 AQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQR-VNSGCV 3050 Query: 175 RLLEPLQERRRLLLASKELHQVAHDLDDELAWVQE--RLPLAMQTERGNGLQAVQQHIKK 232 + L+ + +E+ DLDDEL + R ++Q++ ++ V+ + K Sbjct: 3051 MMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ----IEDVRLFLNK 3106 Query: 233 NQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQV 292 L+ +I+A +LE G L L ++R LE L L E + RQ+ Sbjct: 3107 IHVLKLDIEASEAECRHMLEEEGTLDLL------GLKRELEALNKQCGKLTERGKARQEQ 3160 Query: 293 LDAAF-QVEQYYFDVAEV-EAWLGEQELLMMSEDKGKDEQSTLQLLK--KHLQLEQGVEN 348 L+ +VE +Y + + +A +E + G + + Q L K Q EQ V+ Sbjct: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQ-VDP 3219 Query: 349 YEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLY 406 + + Q++ + L++ D + + + ++ + L ++ +R+A Q+ L+ Sbjct: 3220 LQMKLQQVNGLGQGLIQSAGKDCD-VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3278 Query: 407 --QLSRQVSELEHWIAE-KEVVAGSPELGQDFEHV--SVLQEKFSEFASETGMAGRERLA 461 + + L W+A+ +E++A +++ V + ++K + + A + L Sbjct: 3279 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3338 Query: 462 AVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARE 521 A + + E T + L W ELL R + L L K F + E Sbjct: 3339 AEGGRIAQSAELADREKIT--GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAE 3396 Query: 522 -LQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR--AFEHDLQLLVSQVRQLQEGAAQLR 578 + + ++L + P +A Q+ +R A E D++ + V Q + L Sbjct: 3397 PISDFLSVTEKKL--ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLS 3454 Query: 579 TVYAGEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTADALRFHSQVRDLLSWMDGI 637 ++ + ++ + + + E+ C A L + ++A F ++L+W+ + Sbjct: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEV 3514 Query: 638 ASQIGA 643 ++ + Sbjct: 3515 EDKLSS 3520 Score = 63.2 bits (152), Expect = 8e-10 Identities = 81/401 (20%), Positives = 171/401 (42%), Gaps = 18/401 (4%) Query: 15 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLM-QEKPELAASVRKKLGEIRQCWAELES 73 LH++ H A E+ K+ +++ + GQ L+ Q E +++KL I+ +A++ Sbjct: 3531 LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITV 3590 Query: 74 TTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSME 132 T+ R L +A + A + ++ EL L +E +L G + Q+ + Q + Sbjct: 3591 TSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA---TSGGQSPTGEQIPQFQQRQ 3647 Query: 133 SQVEEWYREVGEL-----QAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQER-RR 185 ++++ E + + A L L P ++E + + + E+ + + + +R Sbjct: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707 Query: 186 LLLASKELHQVAHDLDDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 243 + A + Q D ELAWV E R +A+ R Q Q ++ + +I H Sbjct: 3708 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ-LQVQKAFSIDIIRH 3766 Query: 244 GPRLEEVLERAGALASLRSPEAEAV-RRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQ 301 ++E+ + E + V + E L + + +ER ++ A V Q Sbjct: 3767 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 3826 Query: 302 YYFDVAEVEAWLGE-QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 ++ E+ W+ E + L+ D + Q ++ QL + + ++ I +L + Sbjct: 3827 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 3886 Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401 L E+ + E + + + + +Y +KE +R +AL++ Sbjct: 3887 PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDE 3927 Score = 57.0 bits (136), Expect = 6e-08 Identities = 103/558 (18%), Positives = 227/558 (40%), Gaps = 54/558 (9%) Query: 39 IEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFE-ASKADQLVQSFAE 97 +++ G L E+ ++ +++KLGE+++ ++ + ++A+ +Q+ + + +Q E Sbjct: 1770 LDQHGHNLTPEEQQM---LQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 1826 Query: 98 LDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA----LP 153 + L E +L+++ GG L K Q S E+ G+L+ T + L Sbjct: 1827 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS--EDVISHKGDLRFVTISGQKVLD 1884 Query: 154 LEPASKELVGERQNAVGERLVRLLEPLQER------------RRLLLASKELHQVAHDLD 201 +E + KE G+ + +G + L+ ER L + + HQ + D Sbjct: 1885 MENSFKE--GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSAD 1942 Query: 202 DELAWVQ---ERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 258 AW+Q + + + +Q+ + + L+ E+ H +E++ + A + Sbjct: 1943 SLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIM 2002 Query: 259 SLR---SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF-QVEQYYFDVAEVEAWLG 314 + +P+ V+ + + S + L + R +L A Q + + + +G Sbjct: 2003 EIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIG 2062 Query: 315 EQELLMMSEDKGKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373 E E + + +Q L +++L+Q + + S+ +E + Sbjct: 2063 EVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA 2122 Query: 374 ISR-RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVS-ELEHWIAEK-EVVAGSPE 430 + + + ++V + + L +E+ +L++ ++ +S +L+ ++ K ++A + Sbjct: 2123 VLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ 2182 Query: 431 LGQDFEH-VSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 489 QD H +QE E + +E L + +V EL CG A + + +D + Sbjct: 2183 PDQDITHFFQQIQELNLEMEDQ-----QENLDTLEHLVTELSSCGF--ALDLCQHQDRVQ 2235 Query: 490 EAWAELLELMGT----RAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS 545 + EL T + +L +F R Q ++E +P P E S Sbjct: 2236 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIP----PTETSMS 2291 Query: 546 ASSMQRTLRAFEHDLQLL 563 A +++ + EH LL Sbjct: 2292 AKELEKQI---EHLKSLL 2306 Score = 47.8 bits (112), Expect = 3e-05 Identities = 91/492 (18%), Positives = 193/492 (39%), Gaps = 20/492 (4%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVR--KKLGEIRQCWAELESTTQAKA 79 H ++L +E ++ +G+ ++ + + + + + + + Q W + S + + Sbjct: 4417 HMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4476 Query: 80 RQLFEA-SKADQLVQSFAELDKKLLHMESQLQDVDPGG-DLATVNSQLKKLQSMESQVEE 137 +L EA + A + S E L E L P L TV SQ+++ + ++V Sbjct: 4477 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 4536 Query: 138 WYREVGELQAQTAALPLEPASKE--LVGERQNAVGERLVRLLEPLQERRRLL----LASK 191 ++ EL L ++ L+ +V R ++++ ER R L +K Sbjct: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596 Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVL 251 + H+ L D L + L + E N ++ + K++ ++ + P + + Sbjct: 4597 QFHEAWKKLIDWLEDAESHLD--SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 4654 Query: 252 ERAGALA--SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 309 AL +L +++ + L +++ W + + RQ L+ A + D + Sbjct: 4655 RTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQA 4714 Query: 310 EA-WLGEQELLMMSEDKGK--DEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEM 366 WL + E ++ED+ D + L+ H ++ + ++ L R R L+E Sbjct: 4715 LVDWLYKVEP-QLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN 4773 Query: 367 GHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQ-VSELEHWIAEKE-V 424 D+ + + ++ + + +L ++ LEQ ++ R V L W++E E Sbjct: 4774 SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQT 4833 Query: 425 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEW 484 + L D E + L + EF + + +AV L C T+ W Sbjct: 4834 LRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 4893 Query: 485 KDGLNEAWAELL 496 + + E+L Sbjct: 4894 ITIIRARFEEVL 4905 Score = 46.2 bits (108), Expect = 1e-04 Identities = 122/600 (20%), Positives = 227/600 (37%), Gaps = 119/600 (19%) Query: 3 MARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG 62 M + G ED+ L ++ + A AE+ +N+ L++ ++ QQ + V+ Sbjct: 1300 MMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQ-------YSTIVKDYEL 1352 Query: 63 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKK---LLHMESQLQDVDPGGDLA 119 ++ A +ES ++ ++ S +D + Q F +L + L+ + +Q + Sbjct: 1353 QLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQ--------HVK 1404 Query: 120 TVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEP 179 ++ L++L+ E VEE E+Q V E++ LL Sbjct: 1405 YISDALRRLEEEEKVVEE--------------------------EKQEHV-EKVKELLGW 1437 Query: 180 LQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE 239 + R + D E A +++++ + E + V + IK +Q Sbjct: 1438 VSTLARNTQGKATSSETKESTDIEKAILEQQV---LSEELTTKKEQVSEAIKTSQIF--- 1491 Query: 240 IQAHGPRLEE-----VLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 294 + HG +L E + E+ AL + L+QLQS A E ++Q Sbjct: 1492 LAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNT 1551 Query: 295 AAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH----LQLEQGVEN-- 348 Q+E ++ +W+G+ E + +G+ Q L L+K+ L+ ++N Sbjct: 1552 CHQQLE-------DLCSWVGQAERALAGH-QGRTTQQDLSALQKNQSDLKDLQDDIQNRA 1603 Query: 349 -------------YEESIAQLS-RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394 EE+ +LS R+ AL E H EQ Q + VA KEL E Sbjct: 1604 TSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEET---RVAQKELEEA 1660 Query: 395 RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454 AL+Q E E + EL ++ + + L + + S G Sbjct: 1661 VTSALQQ-------------------ETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 1701 Query: 455 AGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAEL---LELMGTRAQLLAASRE 511 L + Q+ +E G A + G+N+A +L E+M R Q L + ++ Sbjct: 1702 L-LTNLPGMEQLSGASLEKG---ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQ 1757 Query: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571 F + Q +++ L TP E + + + L ++++Q+Q Sbjct: 1758 --NFILATQSAQAFLDQHGHNL----TPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQ 1811 Score = 45.8 bits (107), Expect = 1e-04 Identities = 91/428 (21%), Positives = 168/428 (39%), Gaps = 66/428 (15%) Query: 163 GERQNAVGERLVRLLEPLQERRRLLLASKE----LHQVAHDLDDELAWVQERLPLAMQT- 217 G N V E +L+ + ER + L + E L Q+A+ + + +E+L LA T Sbjct: 395 GYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTL 454 Query: 218 -------ERGNGLQA---VQQHIKKNQGLRREIQA--------HGPRLEEV--------- 250 E G +Q V +I++ +GL R++Q + +LEE+ Sbjct: 455 QADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQD 514 Query: 251 -----------LERAGALASLRSP----------EAEAVRRGLEQLQSAWAGLREAAERR 289 L R G SL +AE + + ++W R+ R Sbjct: 515 ELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSW--FRKPMTRA 572 Query: 290 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349 + V ++ + E V E+ +W+ E ++ + + G D S L+ + VE Sbjct: 573 ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL 632 Query: 350 EESIAQLSRQCRALLEMGHPD-SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQL 408 S+ + + + H +E + + ++Q Y LKE R L+ + + Sbjct: 633 GSSVKEARLYEGKMSQNFHTSYAETLGKLETQ----YCKLKETSSFRMRHLQSLHKF--V 686 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468 SR +EL W+ EKE + + + ++S + FSE E + ++ + Q Sbjct: 687 SRATAELI-WLNEKEEEELAYDWSDNNSNISAKRNYFSELTME--LEEKQDVFRSLQDTA 743 Query: 469 ELIEC-GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527 EL+ H A T+ + + + +L Q + + +FFSDAREL+ + Sbjct: 744 ELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLR 803 Query: 528 EKRRRLPR 535 + + R Sbjct: 804 NLQDSIKR 811 Score = 32.3 bits (72), Expect = 1.5 Identities = 41/211 (19%), Positives = 82/211 (38%), Gaps = 9/211 (4%) Query: 105 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP--LEPASKELV 162 M+ +L+ + G DL +V QL+ Q + + VEE V E + + + E + Sbjct: 599 MQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETL 658 Query: 163 GERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG 222 G+ + + +L E R R L + LH+ EL W+ E+ + + + Sbjct: 659 GKLET----QYCKLKETSSFRMRHL---QSLHKFVSRATAELIWLNEKEEEELAYDWSDN 711 Query: 223 LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL 282 + L E++ + + A L+ P + V +QS + Sbjct: 712 NSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWM 771 Query: 283 REAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313 ++ +Q + Q++ D E+E++L Sbjct: 772 KQLCLCVEQHVKENTAYFQFFSDARELESFL 802 Score = 32.3 bits (72), Expect = 1.5 Identities = 71/395 (17%), Positives = 154/395 (38%), Gaps = 58/395 (14%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK--PELAASVRKKLGEIRQCW 68 D K+ + +H+ F L + + R G+ L ++ PE + + LGE+R W Sbjct: 4625 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 4684 Query: 69 AELESTTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK 127 + + + +L EA + Q + + L L +E QL + P V+ L Sbjct: 4685 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQP------VHGDLDL 4738 Query: 128 LQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE--------- 178 + ++ + + +E+G+ L + + +EL+ ++ +L E Sbjct: 4739 VMNLMDAHKVFQKELGKRTGTVQVL--KRSGRELIENSRDDTTWVKGQLQELSTRWDTVC 4796 Query: 179 --PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL-----QAVQQHIK 231 + ++ RL A K+ + L W+ E A QT R G +A+Q I Sbjct: 4797 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSE----AEQTLRFRGALPDDTEALQSLID 4852 Query: 232 KNQGLRREIQAHGPRLEEVLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQ 290 ++ ++++ + + + ++ P+ ++ + +++ + + A++ Q Sbjct: 4853 THKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQ 4912 Query: 291 QVLDAAFQVEQYYFDVAE-VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349 Q L+ A ++ E + AW+ E ++ D Sbjct: 4913 QRLETALSELVANAELLEELLAWIQWAETTLIQRD------------------------- 4947 Query: 350 EESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 384 +E I Q + +AL+ E+++R+Q VDR+ Sbjct: 4948 QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982 >gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2 [Homo sapiens] Length = 8749 Score = 77.8 bits (190), Expect = 3e-14 Identities = 119/622 (19%), Positives = 260/622 (41%), Gaps = 68/622 (10%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 EL + + L+ +ER ++ ++ + ++RK W E+ + R LF+ Sbjct: 1320 ELRKLESTLDGLERSRER---QERRIQVTLRK--------WERFETNKETVVRYLFQTGS 1368 Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147 + + SF+ L+ + S+L+ K+ +S+ Q E +E E+ Sbjct: 1369 SHERFLSFSSLES----LSSELEQTKEFS---------KRTESIAVQAENLVKEASEI-- 1413 Query: 148 QTAALPLEPASKELVGERQNAVGERLVRLLEPLQER-RRLLLASKELHQVAHDLDDELAW 206 PL P +K+L+ ++ ++ E++ +L + L+E + + + + + + W Sbjct: 1414 -----PLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVW 1468 Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS-LRSPEA 265 + E+ E + A+ I + + +EI++ + + E A + A + + E+ Sbjct: 1469 ITEKEKELNALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGES 1526 Query: 266 EAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQVEQYYFDVAEVEAWLGE-QELLMMSE 323 ++ L Q++ LRE A+ + +L Q +++ ++ +++ + E ++ L + Sbjct: 1527 ARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPI 1586 Query: 324 DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383 T ++L++H+ L Q +E+ +I S R ++ E + +Q D Sbjct: 1587 KICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDI 1646 Query: 384 LYVALKELGEERRVALEQ--QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSV- 440 L A +ER+ ALE +W +L +++S W+ E A SPE+ + V V Sbjct: 1647 LRRA-----KERQTALENLLAHW-QRLEKELSSFLTWLERGEAKASSPEMDISADRVKVE 1700 Query: 441 -----LQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAE 494 +Q +E S+ + + Q+ + L M + + L+E W + Sbjct: 1701 GELQLIQALQNEVVSQASFYSK-----LLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1755 Query: 495 LLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR 554 L +++ R L + H+ F + L + L L T E S M + Sbjct: 1756 LPQIINKRINFLQSVVAEHQQFDEL--LLSFSVWIKLFLSELQTTSE----ISIMDHQVA 1809 Query: 555 AFEH-----DLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609 H +++ +++ LQ A+L ++ E + + ++ Q ++E E Sbjct: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVER 1869 Query: 610 ARLHVSSTADALRFHSQVRDLL 631 +L +S A+ L+ H+ + +L Sbjct: 1870 RQLALSHLAEFLQSHASLSGIL 1891 Score = 53.1 bits (126), Expect = 8e-07 Identities = 110/554 (19%), Positives = 219/554 (39%), Gaps = 76/554 (13%) Query: 48 QEKPELAASVRKKLGEIRQCWAEL-ESTTQAKARQLFEASKADQLVQSFAELDKKLLHME 106 QE ++ + ++L +++ +++ E T A+ + S A L S L + +H+E Sbjct: 4710 QEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLE 4769 Query: 107 SQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQ 166 +DP + Q++ W GEL+ T+A +GE Sbjct: 4770 DLAPHLDP-----------LAYEKARHQIQSWQ---GELKLLTSA----------IGETV 4805 Query: 167 NAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAV 226 R+V+ ++ E R L D L V+ L + + LQ + Sbjct: 4806 TECESRMVQSIDFQTEMSRSL--------------DWLRRVKAELSGPVYLDLN--LQDI 4849 Query: 227 QQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE--AEAVRRGLEQLQSAWAGLRE 284 Q+ I+K Q + E+Q+ R+ L ++ E + + L +L ++E Sbjct: 4850 QEEIRKIQIHQEEVQS-SLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4908 Query: 285 AAERRQQVLDAAF-QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLE 343 A RQ L + Q ++YY WL + + L+ G D +S + LK H++ Sbjct: 4909 ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFF 4968 Query: 344 QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEER--RVALEQ 401 + + ++ +L L + P ++ ++ VA EL +R R + Q Sbjct: 4969 STEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQK-------VASLELRSQRMSRDSGAQ 5021 Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL--------QEKFSEFASETG 453 L + + Q + + A +EV+ + + S+L +EK SE + Sbjct: 5022 VDLLQRCTAQWHDYQK--AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5079 Query: 454 MAG--RERLAAVNQMVDELIECGHTAA-ATMAEWKDGLNEAWAELLELMGTRAQLLA-AS 509 + E++ A+ + +L + G+ A+ AT++ + + W L + + ++L A Sbjct: 5080 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5139 Query: 510 RELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDL---QLLVSQ 566 E F + ++ I++ + +LP + + ++ F +L Q + Sbjct: 5140 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5199 Query: 567 VRQ-----LQEGAA 575 +RQ LQ+GAA Sbjct: 5200 LRQQTLSMLQDGAA 5213 Score = 50.4 bits (119), Expect = 5e-06 Identities = 113/572 (19%), Positives = 238/572 (41%), Gaps = 52/572 (9%) Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95 L +++ Q+ +++ +L + KK+G++ + + T + +L + ++A ++ + Sbjct: 5405 LMELDAAVQKFLEQNGQLGKPLAKKIGKLTELH---QQTIRQAENRLSKLNQAASHLEEY 5461 Query: 96 AELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-GELQAQTAALPL 154 E+ + +L + + + G SQL++ + + E +E+ EL+A T L Sbjct: 5462 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKL-- 5519 Query: 155 EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL---DDELAWVQERL 211 + + E+ + L R E L++ ++ L + L A D+ + EL +Q L Sbjct: 5520 QYLTSVYCTEKMSQQVAELGRETEELRQMIKIRL--QNLQDAAKDMKKFEAELKKLQAAL 5577 Query: 212 PLAMQTERGN--GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR 269 A T G ++++ + Q L E+++ P+++ V AL R PE Sbjct: 5578 EQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSAL---RIPEDVVAS 5634 Query: 270 RGL----EQLQSAWAGLREAAERRQQVLDAAF-QVEQYYFDVAEVEAWL--GEQELLMMS 322 L +LQ + L+ A ++ ++ AA Q EQY ++ ++ + +E+ Sbjct: 5635 LPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI---- 5690 Query: 323 EDKGKDEQSTLQL---LKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 379 EDK + +L + +H +L Q ++ Y+E IA L+ +C+ L + ++ + Sbjct: 5691 EDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLT--VT 5748 Query: 380 QVDRLYVALKELGEE--------RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPEL 431 +V+ L ++L E V + + L V+E ++ P Sbjct: 5749 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC 5808 Query: 432 GQDF----EHVSVLQE--KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485 SV Q+ + ++E ++ E E G +AT A+ Sbjct: 5809 RSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT-AKLG 5867 Query: 486 DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLP-RLTTPPEPRP 544 D L +W L ++ + + L + E + + D+ + I K + +L+ PEP Sbjct: 5868 D-LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ---SISTKMEAIELKLSESPEPGR 5923 Query: 545 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576 S S +A ++ +L ++ +LQ A+ Sbjct: 5924 SPESQMAEHQALMDEILMLQDEINELQSSLAE 5955 Score = 50.1 bits (118), Expect = 7e-06 Identities = 121/574 (21%), Positives = 226/574 (39%), Gaps = 79/574 (13%) Query: 50 KPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ-SFAELDKKLLHMESQ 108 +P L S KLG++++ W L++ K R L+EA + Q Q S + K+ +E + Sbjct: 5855 EPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELK 5914 Query: 109 L-QDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQN 167 L + +PG + SQ+ + Q++ ++ E+ ELQ+ A L S E Q Sbjct: 5915 LSESPEPG---RSPESQMAEHQALMDEILMLQDEINELQSSLAE-ELVSESCEADPAEQL 5970 Query: 168 AVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG----- 222 A+ L L E + R + AS + + L+D+L ++R A+Q R Sbjct: 5971 ALQSTLTVLAERMSTIR--MKASGKRQLLEEKLNDQLE--EQRQEQALQRYRCEADELDS 6026 Query: 223 --------LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL-------------- 260 L K+ + ++ L E+ ++ AL+ L Sbjct: 6027 WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAH 6086 Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQVEQYYFDVAEVEAWLGEQELL 319 EAE + L +L+ + L+ A +Q + A + E+ D+ ++ G QE L Sbjct: 6087 TKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWL 6145 Query: 320 MMSEDK-GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQ 378 + + QS+LQ K +LEQ + + + ++ + +L + H +E Sbjct: 6146 AQARTTWTQQRQSSLQQQK---ELEQELAEQKSLLRSVASRGEEIL-IQHSAAETSGDAG 6201 Query: 379 SQVDRLYVALKELGEERRV---------ALEQQY-----WLYQLSRQVSELEHWIAEKEV 424 + D L L GE+ +L Q++ L + Q E + + Sbjct: 6202 EKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRL 6261 Query: 425 VAGSPELGQDF---------EHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH 475 ++G P D + L + F E +S++G A R+ + ++ D G Sbjct: 6262 LSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYD-----GV 6316 Query: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535 +A +T W D + E L+ + ++E+ D +E+ ++++ + + Sbjct: 6317 SATST---WLDDVEERLFVATALLPEETETCLFNQEI--LAKDIKEMSEEMDKNKNLFSQ 6371 Query: 536 LTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQ 569 PE + ++ TL L LL S V Q Sbjct: 6372 AF--PENGDNRDVIEDTLGCLLGRLSLLDSVVNQ 6403 Score = 46.6 bits (109), Expect = 8e-05 Identities = 138/758 (18%), Positives = 276/758 (36%), Gaps = 151/758 (19%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQ---QLMQEKPELAASVRKK---LGEI 64 D HK + + L + E K +++E Q +LM + + K+ L I Sbjct: 6557 DKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYI 6616 Query: 65 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL-------HMESQLQDVDPG-- 115 + W+ L+ Q +RQL + V E + +L+ H++S L + P Sbjct: 6617 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLY 6676 Query: 116 -------------------------GD--LATVNSQLKKLQSMESQVEEWYREVGE---- 144 G+ L+ N K+L +E+ ++ W R E Sbjct: 6677 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 6736 Query: 145 ----------LQAQTAALPLEPASKELVGERQNA--------------------VGERLV 174 L+ T P E+V + NA G +L+ Sbjct: 6737 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6796 Query: 175 RL-----------LEPLQERRRLLLAS-----KELHQVA-------HDLDDELAWVQERL 211 RL L + + LL + ++LHQ+ H + + ++W+ + Sbjct: 6797 RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWIS-LM 6855 Query: 212 PLAMQTERGN-----GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE 266 +Q + N G +A+ ++++K +G + +I ++ V + ++ + S + E Sbjct: 6856 ENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQ---SVLQISSQDVE 6912 Query: 267 AVRRG-------LEQLQSAWAGLREAAERRQQVLDAAFQV-EQYYFDVAEVEAWLGEQEL 318 + R L + +W L+ + Q+L+ + +Y +V ++ W QE Sbjct: 6913 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 6972 Query: 319 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQI---- 374 + + + D+ S LK LE ++ E+ + ++ + AL++ D I Sbjct: 6973 RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 7032 Query: 375 --------SRRQSQVDRLYVALKELGEE---RRVALEQQYWLYQLSRQVSELEHWIAEKE 423 + V +L + LK + ++ +VA ++ ++ + E + ++ Sbjct: 7033 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK------INSYLMEARYSLSRFR 7086 Query: 424 VVAGSPELGQ-DFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482 ++ GS E Q +++ LQ+ + G + NQ+ L EC T+ Sbjct: 7087 LLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFG----SITNQL---LKECHPPVTETLT 7139 Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSD-ARELQGQIEEKRRRLPRLTTPPE 541 +N W LLE + + Q A +L + + D +++ ++++ R L Sbjct: 7140 NTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAAT 7199 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQ----LQEGAAQLRTVYAGEHAEAIASREQEVL 597 + A T +DL + V+ L E QL+ A AI S + + Sbjct: 7200 NKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS 7259 Query: 598 QGWKELLSA-CEDARLHVSSTADALRFHSQVRDLLSWM 634 Q L A C+ + D F + L +W+ Sbjct: 7260 QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 7297 Score = 44.7 bits (104), Expect = 3e-04 Identities = 122/621 (19%), Positives = 244/621 (39%), Gaps = 75/621 (12%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQE-KPELAASVRKKLGEIRQCWAELESTTQAKAR 80 H+ F AE+ ++ L I +GQ+L+++ + + KL + W + Q + Sbjct: 7426 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7485 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 + + Q + AE +K L S L P L +V L++ +++ +V+ ++ Sbjct: 7486 IIDSQIRQWQRYREMAEKLRKWLVEVSYL----PMSGLGSVPIPLQQARTLFDEVQ--FK 7539 Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER-----RRLLLASKELHQ 195 E L+ Q + + A K+L+ + L L +QE+ RL K+L Sbjct: 7540 EKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF 7599 Query: 196 VAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAG 255 + D + + + L ++T + Q++ H E+ A R +E+ G Sbjct: 7600 LLKDWEKCEKGIADSLE-KLRTFKKKLSQSLPDH-------HEELHAEQMRCKELENAVG 7651 Query: 256 A---------------LASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQV 299 + A + + + + +E LQ W L + + RRQQ+ + + Sbjct: 7652 SWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEW 7711 Query: 300 EQYYFDVAEVEAWLGEQE----------LLMMSEDKGKDEQSTLQLLKKH-LQLEQGVEN 348 + E+ WL + E + M E KD Q + + +++ +QL+Q Sbjct: 7712 AVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQ---- 7767 Query: 349 YEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQL 408 E +A+ S + +A E+ + + R Q +D + +K+L +E VA++ QL Sbjct: 7768 MGERLAKASHESKA-SEIEYKLGKVNDRWQHLLDLIAARVKKL-KETLVAVQ------QL 7819 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS--------ETGMAGRERL 460 + +S L W+A E P + D + +Q K +E TG+A L Sbjct: 7820 DKNMSSLRTWLAHIESELAKP-IVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL 7878 Query: 461 AAVNQMVDELIECGHTAAA-TMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKFFSD 518 V ++ + C A ++ + L+ W + + M R ++ R KF D Sbjct: 7879 CEV--LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 7936 Query: 519 ARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLR 578 + ++ R ++ A + AF+ + ++Q+ + + Q R Sbjct: 7937 YSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINK---QYR 7993 Query: 579 TVYAGEHAEAIASREQEVLQG 599 + ++ S +Q V +G Sbjct: 7994 RLARENRTDSACSLKQMVHEG 8014 Score = 43.9 bits (102), Expect = 5e-04 Identities = 62/314 (19%), Positives = 123/314 (39%), Gaps = 26/314 (8%) Query: 95 FAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPL 154 F + KL ME + Q VD A +++ + +VEE E+ ++ Sbjct: 3600 FNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSR 3659 Query: 155 EPASKELVGERQNAVGERLVRLLEP----------LQERRRLLLASKELHQVAHDLDDEL 204 + R A+ L+++LE L+E L + + + H + Sbjct: 3660 MGCQATQLTSRYQAL---LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNV 3716 Query: 205 AWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE 264 A +++ M ++ L+ + + ++K L + + G R + LE E Sbjct: 3717 ATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEG---------E 3767 Query: 265 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGE-QELLMMS 322 AE +R+ + L + L+ + + + D + + W+ E QE+L + Sbjct: 3768 AERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3827 Query: 323 EDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDS--EQISRRQSQ 380 E+ + L K+ L+Q V ++E S+ + + ALLE+ + ++I + QS Sbjct: 3828 EEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSD 3887 Query: 381 VDRLYVALKELGEE 394 L K + EE Sbjct: 3888 YQDLCSIGKAMMEE 3901 Score = 42.7 bits (99), Expect = 0.001 Identities = 108/587 (18%), Positives = 218/587 (37%), Gaps = 84/587 (14%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE-KPELAASVRKKLGEIRQCWA 69 D L R L+ +A ++ + + ++ I G+ ++Q PE +++++L ++ WA Sbjct: 3319 DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWA 3378 Query: 70 ELEST-TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD-PGGDLATVNSQLKK 127 L S + K++ SK + + ME+ L + + +L + L K Sbjct: 3379 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3438 Query: 128 LQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLEPLQERR 184 + + +V + + ++ + A + + + + ER A+ E R E + + Sbjct: 3439 AKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQE---RAKEAVTKSE 3495 Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERG--------NGLQAVQQHIKKNQGL 236 +L+ +E + + L QE+L E LQ +Q H + Q L Sbjct: 3496 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL 3555 Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295 L VL + P+AE R LE L+ W A +E R Q + Sbjct: 3556 ----------LNSVLHTREDVIPSGIPQAE--DRALESLRQDWQAYQHRLSETRTQFNNV 3603 Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 355 ++ +V+ WL E E K +E V Y + + + Sbjct: 3604 VNKLRLMEQKFQQVDEWLKTAE-----EKKWHEE----------------VTAYRDEVEE 3642 Query: 356 LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL 415 + + + +L+ H +S + R L ++ E+ + E+ L + +S Sbjct: 3643 VGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSY 3702 Query: 416 EHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH 475 W ++F++V+ +K +T M G+ +L + ++ ++ E GH Sbjct: 3703 SDWYGSTH---------KNFKNVATKIDKV-----DTVMMGK-KLKTLEVLLKDM-EKGH 3746 Query: 476 TAAATMAEWKDG----LNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRR 531 + + E + L E AE L +E+H +EL + ++ Sbjct: 3747 SLLKSAREKGERAVKYLEEGEAERLR------------KEIHDHMEQLKELTSTVRKEHM 3794 Query: 532 RLPR-LTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577 L + L E ++ + + ++ L + +L E AQL Sbjct: 3795 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQL 3841 Score = 40.4 bits (93), Expect = 0.005 Identities = 67/303 (22%), Positives = 123/303 (40%), Gaps = 24/303 (7%) Query: 33 KEWLEKIEREGQQLMQEKPELAAS-VRKKLGEIRQCWAELESTTQAKARQLFEASKADQ- 90 K+ L + G+QL Q+ AAS ++ + Q LE K + +A D Sbjct: 7226 KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQAL-CKQQTSLQAGVLDYE 7284 Query: 91 -LVQSFAELDKKLLHMESQLQDVDPG--GDLATVNSQLKKLQSMESQVEEWYREVGELQA 147 +S L+ ++ E LQ DP DL+T+ ++++L+ + ++ L Sbjct: 7285 TFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE 7344 Query: 148 QTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWV 207 LPL KE+ +R + + ER L + HQ L+ W+ Sbjct: 7345 LGYRLPLN--DKEI--KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF--LEKCETWM 7398 Query: 208 QERLPLAMQTERGNGLQAV--QQHIKKNQGLRREIQAHGPRLEEVL-----ERAGALASL 260 + +QTE+ ++ QH+ + Q QA +++L + L Sbjct: 7399 E----FLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG 7454 Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQELL 319 + + + L L + W G+ A++R+ ++D+ + Q Y ++AE + WL E L Sbjct: 7455 QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYL 7514 Query: 320 MMS 322 MS Sbjct: 7515 PMS 7517 Score = 38.9 bits (89), Expect = 0.016 Identities = 100/569 (17%), Positives = 219/569 (38%), Gaps = 98/569 (17%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82 Q A+L Q E ++I + +++ + V K + +I + ++E + A+ Sbjct: 2282 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ-- 2339 Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142 ++ + ++ ++ K+L +S + +NS +K S E + + Sbjct: 2340 ---NETCEALKKVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELE------SL 2385 Query: 143 GELQAQTAALPLEPASKELVGERQNAVGERLVR-LLEPLQERRRLLLASKELHQVAHDLD 201 G +A T + A +L + Q ++ E L + E +QE + L +K + + D Sbjct: 2386 G--RAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRT 2443 Query: 202 DELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLR 261 + ++ +L + LQ + + Q + G L L + + Sbjct: 2444 GDSKVLEAKL---------HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSK-----QIV 2489 Query: 262 SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM 321 S E + + E+ Q A L++ + +Q + D A ++ + ++ W+ E E Sbjct: 2490 SSIQEQITKANEEFQ---AFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFN 2546 Query: 322 SEDKGKDEQSTLQLLKKHLQLEQGVENY---EESIAQLSRQCRALLEMGHPDSEQISRRQ 378 +E+ G+ +Q + + ++E + ES+ +LS++ + L E GH ++ R Sbjct: 2547 TENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQE-GRLC 2605 Query: 379 SQVDRLYVALKELGEER----RVALEQQYWLYQLSRQ----VSELEHWIAEKEVVAGSPE 430 SQ+ + L + +E+ +VAL++ L + + V ++ +A E GS + Sbjct: 2606 SQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKD 2665 Query: 431 -LGQDFEHVSVLQEKFSEFASETGMA---GRERLAAVNQ-------------------MV 467 L + + + E + MA G + L + N+ ++ Sbjct: 2666 TLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIM 2725 Query: 468 DELIECGHTAAATMAEWKD---------------------------GLNEAWAELLELMG 500 + T + +++W D GL E + L L Sbjct: 2726 SSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQS 2785 Query: 501 TRAQLLAASRELHKFFSDARELQGQIEEK 529 ++ +R LH+ + +REL + E++ Sbjct: 2786 ILSEAEDHTRALHRLIAKSRELYEKTEDE 2814 Score = 37.4 bits (85), Expect = 0.046 Identities = 122/634 (19%), Positives = 231/634 (36%), Gaps = 99/634 (15%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQE-----KPELAASVRKKLGEIRQCWAELESTTQA 77 +A M E+A ++ L ++ +G L+ + + +L +V L + ++ + ST Q Sbjct: 3896 KAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQR 3955 Query: 78 KARQLFE-----ASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSME 132 + L S+ D L Q A L +E Q P A Q+K ++++ Sbjct: 3956 MYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ---PPLSRAEAIKQVKHFRALQ 4012 Query: 133 SQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKE 192 Q Y ++ + ++ +K+ + + + + ++LV+ Q + E Sbjct: 4013 EQART-YLDLLCSMCDLSNASVKTTAKD-IQQTEQTIEQKLVQAQNLTQGWEEIKHLKSE 4070 Query: 193 LHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLE 252 L D D +L ++ R N + V+ +KK Q + + ++E Sbjct: 4071 LWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNT-------IIE 4123 Query: 253 RAGALASLR-SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEA 311 + L SPE + + L W L + + Q + Y D V Sbjct: 4124 KVNKLTKKEESPE----HKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVE 4179 Query: 312 WLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDS 371 E+ D +ST L+ +L ++ + +I L Q Sbjct: 4180 VFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQ------------ 4227 Query: 372 EQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPEL 431 +Q ++ L + KEL +E+ LEQ+++ +LE I K V+ + Sbjct: 4228 -----KQKMIEHLNLDDKELVKEQTSHLEQRWF---------QLEDLIKRKIQVSVT--- 4270 Query: 432 GQDFEHVSVLQEKFS---EFASETGMAGRERL-------AAVNQMVDELIECGHTAAATM 481 + E ++V+Q +F E+A E E L A N ++D L C A M Sbjct: 4271 --NLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4328 Query: 482 ---AEWKD--------GLNEAWAE-------------LLELMGTRAQLL-AASRELHKFF 516 + KD GLNE L +L+G R + L A E +F Sbjct: 4329 LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFL 4388 Query: 517 SDARELQGQIEEKRRRL---PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEG 573 + QI++ R++ + P+ S +T ++ + L+ ++V L Sbjct: 4389 MAVFQATSQIQQHERKIMFREHICLLPD---DVSKQVKTCKSAQASLKTYQNEVTGLWAQ 4445 Query: 574 AAQLRTVYAGEHAEAIASREQEVLQGWKELLSAC 607 +L + + + QE+ + +L C Sbjct: 4446 GRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC 4479 Score = 37.0 bits (84), Expect = 0.060 Identities = 93/533 (17%), Positives = 203/533 (38%), Gaps = 46/533 (8%) Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVG--ERQNAVGERLV 174 +++ V++ L+K+Q S+ E ++ + ++ L ++ G + A E Sbjct: 3103 NISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWK 3162 Query: 175 RLLEPLQERRRLL----LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHI 230 L ++ L + K+ A + D L+ ++ + + + R L A ++ Sbjct: 3163 NFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHES--SNRLYDLPAKRREQ 3220 Query: 231 KKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQ 290 +K Q + EI + P+L + E+A L ++ +++ R + QL S + L + + Sbjct: 3221 QKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA-ASKSFRHRVSQLSSQYLALSNLTKEKV 3279 Query: 291 QVLD-AAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349 LD + Q+ + E++ W+ + ++ S ++S L L+ V+ Sbjct: 3280 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3339 Query: 350 EE-SIAQLSRQCRALLEMGHPDSEQISRRQSQ-VDRLYVALKELGEERRVALE---QQYW 404 +E + + + ++L+ P+ ++Q Q V ++ +L G + LE ++ Sbjct: 3340 KEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWT 3399 Query: 405 LYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVN 464 YQ V + W+ E +++ + + +E +T M G+ +L Sbjct: 3400 SYQ--DGVRQFSGWMDSMEA------------NLNESERQHAELRDKTTMLGKAKL---- 3441 Query: 465 QMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQG 524 ++E + + T+ G+ E + LEL + + A + + + +L Sbjct: 3442 --LNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVR 3499 Query: 525 QIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ----EGAAQLRTV 580 +E +R L L H + + +++LQ EG A L +V Sbjct: 3500 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3559 Query: 581 YAGEH---AEAIASREQEVL----QGWKELLSACEDARLHVSSTADALRFHSQ 626 I E L Q W+ + R ++ + LR Q Sbjct: 3560 LHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3612 Score = 36.2 bits (82), Expect = 0.10 Identities = 85/420 (20%), Positives = 165/420 (39%), Gaps = 42/420 (10%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPEL-AASVRKKLGEIRQCWAELESTTQAKARQ 81 +AF E++ N +E+I +G+QL+++ L AA + ++L E+R+ E+ + ++ Sbjct: 8079 KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8138 Query: 82 LFEASKADQLVQ-SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 L D S EL+ + S L D D L +Q R Sbjct: 8139 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8198 Query: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199 + A ++PLE +L + ++A+ L E Q+ + L Sbjct: 8199 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMI 8258 Query: 200 LDDELAWVQ-----------ERLPLAMQTER-GNGLQAVQQHIKKNQGLRREIQAHGPRL 247 + A+V+ + L Q + G L + I++ + + R GP L Sbjct: 8259 PESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL 8318 Query: 248 EEVLERAGALASLRSPEAEAVRR----------------GLEQLQSAWAGLREAAERRQ- 290 + + L S ++V+R L ++ AG+ + E Q Sbjct: 8319 DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQA 8378 Query: 291 QVLDAAFQV-------EQYYFDVAEVEAWLG--EQELLMMSEDKGKDEQSTLQL-LKKHL 340 Q L ++ +Q+ D+ + AWLG E+EL + + + T++L +KK Sbjct: 8379 QALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK 8438 Query: 341 QLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 400 +L++ V++ + I ++ + +S + R SQ++ + + L EE R L+ Sbjct: 8439 ELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQ 8498 Score = 35.8 bits (81), Expect = 0.13 Identities = 113/552 (20%), Positives = 214/552 (38%), Gaps = 90/552 (16%) Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 69 E +++HK + F+ EL +E L+K+ + G QL+ E+ A + ++ Sbjct: 2559 EKKNEVHKV----EMFLGELLAARESLDKLSQRG-QLLSEEGHGAGQEGRLCSQLLTSHQ 2613 Query: 70 ELESTTQAKARQ----LFEASKADQLVQSF----AELDKKLLHMESQLQDVDPGGDLATV 121 L T+ K R L E ++ +QS + +L ES L G T+ Sbjct: 2614 NLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTL------GSKDTL 2667 Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 181 +L ++Q + E GE++ A E A + E Q + +L L E Sbjct: 2668 EKRLSQIQDILLMKGE-----GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWA 2722 Query: 182 E-RRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 + + A L V +D ER N L+ + + +Q + + Sbjct: 2723 DIMSSSVHAQSTLESVISQWND-------------YVERKNQLEQWMESV--DQKIEHPL 2767 Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 Q P L+E L S+ S EAE R L +L + ++ E ++ D +F+ Sbjct: 2768 QPQ-PGLKEKFVLLDHLQSILS-EAEDHTRALHRL------IAKSRELYEKTEDESFK-- 2817 Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 D A+ E +++ ++++K + + +++K HL V + + + + Sbjct: 2818 ----DTAQEELKTQFNDIMTVAKEKMRKVE---EIVKDHLMYLDAVHEFTDWLHSAKEEL 2870 Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420 +M DS ++ S++ L + +E+G R +E + + S E Sbjct: 2871 HRWSDMS-GDSSATQKKLSKIKEL-IDSREIGASRLSRVESLAPEVKQNTTASGCELMHT 2928 Query: 421 EKEVVAGSPELGQD--FEHVSVLQEKFSEFA-SETGMAGR--------ERLAAV------ 463 E + + + +D F+ S L+ S+ A SE +G+ E+ +A+ Sbjct: 2929 EMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQ 2988 Query: 464 -------NQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 516 +E++EC H E D L +A +L +L SR+L + Sbjct: 2989 QLTLLEGKNTDEEIVECWHKG----QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY- 3043 Query: 517 SDARELQGQIEE 528 + ++ G I+E Sbjct: 3044 --SGKVSGLIKE 3053 Score = 35.8 bits (81), Expect = 0.13 Identities = 86/418 (20%), Positives = 163/418 (38%), Gaps = 53/418 (12%) Query: 237 RREIQAHGPRLEEVLE------RAGALASLRSPEAEAVR-RGLEQLQSAWAGLREAAERR 289 R E++ G R +E+L+ R G A+ + +A+ + LEQ++ ++ E Sbjct: 3637 RDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESE 3696 Query: 290 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349 + + + + V + + + +MM + E + K H L+ E Sbjct: 3697 SSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKG 3756 Query: 350 EESIAQLSR-QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQL 408 E ++ L + L + H EQ+ S V + ++ L E+ + L +++ Sbjct: 3757 ERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTL-----EKGLHLAKEF----- 3806 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS-----ETGMAGRERLAAV 463 S + L WIAE + + PE E L EK ++ + +T ++ + +V Sbjct: 3807 SDKCKALTQWIAEYQEILHVPE-----EPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSV 3861 Query: 464 NQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRE-LHKFFSDAREL 522 + + L+E T+ + D L + +L + + +A + L+ L Sbjct: 3862 REKGEALLEL--VQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTL 3919 Query: 523 QGQIEEKRRRLPRLT-------TPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA 575 GQ + + + T S+ QR ++ EH+LQ VS+ LQ+ A Sbjct: 3920 IGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA 3979 Query: 576 QLRTVYAG---------EHAEAIASRE-----QEVLQGWKELL-SACEDARLHVSSTA 618 L V AEAI + QE + + +LL S C+ + V +TA Sbjct: 3980 WLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4037 Score = 34.7 bits (78), Expect = 0.30 Identities = 111/623 (17%), Positives = 239/623 (38%), Gaps = 49/623 (7%) Query: 38 KIEREGQQLMQEKPELAASVRKKLGEIRQCWAELE----STTQAKARQLFEASKADQLVQ 93 +++R G +L E+P + ++L +++ + EL S + L S+ ++ +Q Sbjct: 6471 ELKRRGDKLQVEQPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6525 Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 153 A+L +E+ + + GD + S +++Q + + +E+++ + T L Sbjct: 6526 DLADL------LETGQEKM--AGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLF 6577 Query: 154 LEPASKELVGERQ------NAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWV 207 + S + E Q L R + E +L L + +L +L V Sbjct: 6578 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV 6637 Query: 208 QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEA 267 + +P E + I Q L+ + + P+L +VL+ L L S Sbjct: 6638 ESSIPSVGLVEENE--DRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL--LISISCSD 6693 Query: 268 VRRGLEQLQSAWAGLREAAERRQQVLDAAFQV-EQYYFDVAEVEAWL-GEQELLMMSEDK 325 + L QL W + L+ + +Y + A++ WL ++ L + Sbjct: 6694 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ 6753 Query: 326 GKDEQSTLQLLKKHL----QLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQV 381 L++++ HL + + V+ + + LL + D+ + S++ Sbjct: 6754 SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRI 6813 Query: 382 DRLYVALKELGEERRVALEQQYWLYQLSRQ-VSELEHWIAEKEVVAGSPE------LGQD 434 D + L + L Q SR +SE+ WI+ E V E +G Sbjct: 6814 DSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG-- 6871 Query: 435 FEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAATMAEWKDGLNE 490 ++ + +K+ F + + + VNQ V ++ +E + AE +N+ Sbjct: 6872 YKAIHEYLQKYKGFKIDINCK-QLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNK 6930 Query: 491 AWAELLELMGTRAQLLAASRE-LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549 +W L L+ + QLL E ++ ++ + L+ E + +RL + + + S + Sbjct: 6931 SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNA 6989 Query: 550 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609 + + E ++ +V ++++ L + + + S +E+ Q W L Sbjct: 6990 LKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQ 7049 Query: 610 ARLHVSSTADALRFHSQVRDLLS 632 ++ + S D H D ++ Sbjct: 7050 LKILLKSVLDQWSSHKVAFDKIN 7072 Score = 33.1 bits (74), Expect = 0.86 Identities = 47/236 (19%), Positives = 102/236 (43%), Gaps = 20/236 (8%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81 ++ +M L + ++ ++R +L +E+ L V E Q ++ +A+ Sbjct: 8322 YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET-QTAGVIDRWELLQAQA 8380 Query: 82 LFEASKADQLVQSFAELDKKLLHMES----------QLQDVDPGGDLATVNSQLKKLQSM 131 L + + Q +Q + + + L + + QLQ ++ D+ T+ Q+KKL+ + Sbjct: 8381 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKEL 8440 Query: 132 ESQVEEWYREVGELQAQTAALPLEPA-SKEL--VGERQNAVGERLVRLLEPLQERRRL-- 186 + V+ +R+ L + A SKE + +R + + R R+ L+E R L Sbjct: 8441 QKAVD--HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQ 8498 Query: 187 --LLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 L+ + H+++H L L + R + + + +Q H K+ ++ E+ Sbjct: 8499 DALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 8554 Score = 32.7 bits (73), Expect = 1.1 Identities = 92/467 (19%), Positives = 179/467 (38%), Gaps = 79/467 (16%) Query: 28 ELAQNKEWLEKIEREGQQLM---QEKPELAASVRKKLGEIRQCWAELESTTQAKA----- 79 +L + KE + E QQL+ +E + S LG+I + LE Q+ A Sbjct: 802 QLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQK 861 Query: 80 ------------RQLFEASKADQLVQSFAELDKKLLH-----MESQLQDVDPG------- 115 + L K Q VQ F L L H ++ Q+ D+ Sbjct: 862 HQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKK 921 Query: 116 -GD----LATVNSQLKKLQSMESQVEEWYREVGE-LQAQTAALPLEPASKELVGERQNAV 169 GD + T + +KK + +++E+ R E L+ + L E + V Sbjct: 922 TGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV 981 Query: 170 GERLVRLLE------PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 223 ++ + P QE++ L A ++LH+ DL E + L L + E+ L Sbjct: 982 LNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPY--HLLHLKIDVEKNRFL 1039 Query: 224 QAVQQ---------HIKKNQGLRREIQAH-------GPR--LEEVLERAGALASLRSPEA 265 +V++ + +G + I+ H GP E+ L+ L ++ P Sbjct: 1040 ASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELC-VKLPVR 1098 Query: 266 EAVRRGLEQLQSAWAGLREAAERR-QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMS-E 323 + VR LR A + +++++ + + Y +E +W+ E + + Sbjct: 1099 DPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIK 1158 Query: 324 DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383 + D + ++ + ++ GV E+++ L + + L E+ + Q ++ ++ + Sbjct: 1159 GEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQ--KQGDELAK 1216 Query: 384 LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430 L + K L V L L ++ + +S + KE+V S E Sbjct: 1217 LSSSFKAL-----VTL-----LSEVEKMLSNFGDCVQYKEIVKNSLE 1253 >gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1 [Homo sapiens] Length = 8797 Score = 77.8 bits (190), Expect = 3e-14 Identities = 119/622 (19%), Positives = 260/622 (41%), Gaps = 68/622 (10%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 EL + + L+ +ER ++ ++ + ++RK W E+ + R LF+ Sbjct: 1313 ELRKLESTLDGLERSRER---QERRIQVTLRK--------WERFETNKETVVRYLFQTGS 1361 Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147 + + SF+ L+ + S+L+ K+ +S+ Q E +E E+ Sbjct: 1362 SHERFLSFSSLES----LSSELEQTKEFS---------KRTESIAVQAENLVKEASEI-- 1406 Query: 148 QTAALPLEPASKELVGERQNAVGERLVRLLEPLQER-RRLLLASKELHQVAHDLDDELAW 206 PL P +K+L+ ++ ++ E++ +L + L+E + + + + + + W Sbjct: 1407 -----PLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVW 1461 Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS-LRSPEA 265 + E+ E + A+ I + + +EI++ + + E A + A + + E+ Sbjct: 1462 ITEKEKELNALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGES 1519 Query: 266 EAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQVEQYYFDVAEVEAWLGE-QELLMMSE 323 ++ L Q++ LRE A+ + +L Q +++ ++ +++ + E ++ L + Sbjct: 1520 ARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPI 1579 Query: 324 DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383 T ++L++H+ L Q +E+ +I S R ++ E + +Q D Sbjct: 1580 KICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDI 1639 Query: 384 LYVALKELGEERRVALEQ--QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSV- 440 L A +ER+ ALE +W +L +++S W+ E A SPE+ + V V Sbjct: 1640 LRRA-----KERQTALENLLAHW-QRLEKELSSFLTWLERGEAKASSPEMDISADRVKVE 1693 Query: 441 -----LQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK-DGLNEAWAE 494 +Q +E S+ + + Q+ + L M + + L+E W + Sbjct: 1694 GELQLIQALQNEVVSQASFYSK-----LLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1748 Query: 495 LLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR 554 L +++ R L + H+ F + L + L L T E S M + Sbjct: 1749 LPQIINKRINFLQSVVAEHQQFDEL--LLSFSVWIKLFLSELQTTSE----ISIMDHQVA 1802 Query: 555 AFEH-----DLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609 H +++ +++ LQ A+L ++ E + + ++ Q ++E E Sbjct: 1803 LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVER 1862 Query: 610 ARLHVSSTADALRFHSQVRDLL 631 +L +S A+ L+ H+ + +L Sbjct: 1863 RQLALSHLAEFLQSHASLSGIL 1884 Score = 63.9 bits (154), Expect = 5e-10 Identities = 108/577 (18%), Positives = 221/577 (38%), Gaps = 43/577 (7%) Query: 59 KKLGEIRQCWAELESTTQAKARQLFEA-SKADQLVQSFAELDKKLLHMESQLQD-VDPGG 116 + L +RQ W + Q +K + Q F ++D+ L E ++ Sbjct: 3570 RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQS 3629 Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 176 + AT QL +++ +V + EV E+ A+ + E +G + + R L Sbjct: 3630 NRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQAL 3689 Query: 177 L--------------EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG 222 L + L+E L + + + H +A +++ M ++ Sbjct: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749 Query: 223 LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL 282 L+ + + ++K L + + G R + LE EAE +R+ + L Sbjct: 3750 LEVLLKDMEKGHSLLKSAREKGERAVKYLEEG---------EAERLRKEIHDHMEQLKEL 3800 Query: 283 REAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGE-QELLMMSEDKGKDEQSTLQLLKKHL 340 + L+ + + + D + + W+ E QE+L + E+ + L K+ Sbjct: 3801 TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYK 3860 Query: 341 QLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 400 L+Q V ++E S+ + + ALLE+ + + Q Q D Y L +G+E +LE Sbjct: 3861 SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSD--YQDLCSIGKEHVFSLE 3918 Query: 401 QQYWLYQ-LSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG-RE 458 + ++ + ++ E+E W+ + +P+L + ++ Q+ A +AG + Sbjct: 3919 AKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978 Query: 459 RLAAVNQMVDELI-ECGHTAAATMAE----WKDGLNEAWAELLELMGTRAQLLAASRELH 513 RL + D LI +C A + + G ++++ + Q L + H Sbjct: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038 Query: 514 KFFSDA-RELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQL---LVSQVRQ 569 D ++ Q + + L PP R A + RA + + L+ + Sbjct: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCD 4098 Query: 570 LQEGAAQLRTVYAGEHAEAIASR---EQEVLQGWKEL 603 L + + + + I + Q + QGW+E+ Sbjct: 4099 LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135 Score = 53.1 bits (126), Expect = 8e-07 Identities = 123/675 (18%), Positives = 264/675 (39%), Gaps = 77/675 (11%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE-KPELAASVRKKLGEIRQCWA 69 D L R L+ +A ++ + + ++ I G+ ++Q PE +++++L ++ WA Sbjct: 3312 DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWA 3371 Query: 70 ELEST-TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD-PGGDLATVNSQLKK 127 L S + K++ SK + + ME+ L + + +L + L K Sbjct: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431 Query: 128 LQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLEPLQERR 184 + + +V + + ++ + A + + + + ER A+ E R E + + Sbjct: 3432 AKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQE---RAKEAVTKSE 3488 Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERG--------NGLQAVQQHIKKNQGL 236 +L+ +E + + L QE+L E LQ +Q H + Q L Sbjct: 3489 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL 3548 Query: 237 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDA 295 L VL + P+AE R LE L+ W A +E R Q + Sbjct: 3549 ----------LNSVLHTREDVIPSGIPQAE--DRALESLRQDWQAYQHRLSETRTQFNNV 3596 Query: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIA 354 ++ +V+ WL E + + + ++T ++ L + + + V Y + + Sbjct: 3597 VNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVE 3656 Query: 355 QLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSE 414 ++ + + +L+ H +S + R L ++ E+ + E+ L + +S Sbjct: 3657 EVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSS 3716 Query: 415 LEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECG 474 W ++F++V+ +K +T M G+ +L + ++ ++ E G Sbjct: 3717 YSDWYGSTH---------KNFKNVATKIDKV-----DTVMMGK-KLKTLEVLLKDM-EKG 3760 Query: 475 HTAAATMAEWKDG----LNEAWAELL-----ELMGTRAQLLAASRELHKFFSDARELQGQ 525 H+ + E + L E AE L + M +L + R+ H L + Sbjct: 3761 HSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKE 3820 Query: 526 IEEKRRRLPR--------LTTPPEPRPSASSMQRTLRAFEHDLQLLVS------QVRQLQ 571 +K + L + L P EP+ + L ++ Q ++S VR+ Sbjct: 3821 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880 Query: 572 EGAAQL-RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDL 630 E +L + V + + + S Q++ KE + + E + D ++S+++++ Sbjct: 3881 EALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLE------AKVKDHEDYNSELQEV 3934 Query: 631 LSWMDGIASQIGAAD 645 W+ ++ ++ A D Sbjct: 3935 EKWLLQMSGRLVAPD 3949 Score = 53.1 bits (126), Expect = 8e-07 Identities = 110/554 (19%), Positives = 219/554 (39%), Gaps = 76/554 (13%) Query: 48 QEKPELAASVRKKLGEIRQCWAEL-ESTTQAKARQLFEASKADQLVQSFAELDKKLLHME 106 QE ++ + ++L +++ +++ E T A+ + S A L S L + +H+E Sbjct: 4781 QEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLE 4840 Query: 107 SQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQ 166 +DP + Q++ W GEL+ T+A +GE Sbjct: 4841 DLAPHLDP-----------LAYEKARHQIQSWQ---GELKLLTSA----------IGETV 4876 Query: 167 NAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAV 226 R+V+ ++ E R L D L V+ L + + LQ + Sbjct: 4877 TECESRMVQSIDFQTEMSRSL--------------DWLRRVKAELSGPVYLDLN--LQDI 4920 Query: 227 QQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE--AEAVRRGLEQLQSAWAGLRE 284 Q+ I+K Q + E+Q+ R+ L ++ E + + L +L ++E Sbjct: 4921 QEEIRKIQIHQEEVQS-SLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979 Query: 285 AAERRQQVLDAAF-QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLE 343 A RQ L + Q ++YY WL + + L+ G D +S + LK H++ Sbjct: 4980 ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFF 5039 Query: 344 QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEER--RVALEQ 401 + + ++ +L L + P ++ ++ VA EL +R R + Q Sbjct: 5040 STEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQK-------VASLELRSQRMSRDSGAQ 5092 Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL--------QEKFSEFASETG 453 L + + Q + + A +EV+ + + S+L +EK SE + Sbjct: 5093 VDLLQRCTAQWHDYQK--AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150 Query: 454 MAG--RERLAAVNQMVDELIECGHTAA-ATMAEWKDGLNEAWAELLELMGTRAQLLA-AS 509 + E++ A+ + +L + G+ A+ AT++ + + W L + + ++L A Sbjct: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210 Query: 510 RELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDL---QLLVSQ 566 E F + ++ I++ + +LP + + ++ F +L Q + Sbjct: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270 Query: 567 VRQ-----LQEGAA 575 +RQ LQ+GAA Sbjct: 5271 LRQQTLSMLQDGAA 5284 Score = 50.4 bits (119), Expect = 5e-06 Identities = 113/572 (19%), Positives = 238/572 (41%), Gaps = 52/572 (9%) Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95 L +++ Q+ +++ +L + KK+G++ + + T + +L + ++A ++ + Sbjct: 5476 LMELDAAVQKFLEQNGQLGKPLAKKIGKLTELH---QQTIRQAENRLSKLNQAASHLEEY 5532 Query: 96 AELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-GELQAQTAALPL 154 E+ + +L + + + G SQL++ + + E +E+ EL+A T L Sbjct: 5533 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKL-- 5590 Query: 155 EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDL---DDELAWVQERL 211 + + E+ + L R E L++ ++ L + L A D+ + EL +Q L Sbjct: 5591 QYLTSVYCTEKMSQQVAELGRETEELRQMIKIRL--QNLQDAAKDMKKFEAELKKLQAAL 5648 Query: 212 PLAMQTERGN--GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR 269 A T G ++++ + Q L E+++ P+++ V AL R PE Sbjct: 5649 EQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSAL---RIPEDVVAS 5705 Query: 270 RGL----EQLQSAWAGLREAAERRQQVLDAAF-QVEQYYFDVAEVEAWL--GEQELLMMS 322 L +LQ + L+ A ++ ++ AA Q EQY ++ ++ + +E+ Sbjct: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI---- 5761 Query: 323 EDKGKDEQSTLQL---LKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 379 EDK + +L + +H +L Q ++ Y+E IA L+ +C+ L + ++ + Sbjct: 5762 EDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLT--VT 5819 Query: 380 QVDRLYVALKELGEE--------RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPEL 431 +V+ L ++L E V + + L V+E ++ P Sbjct: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC 5879 Query: 432 GQDF----EHVSVLQE--KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK 485 SV Q+ + ++E ++ E E G +AT A+ Sbjct: 5880 RSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT-AKLG 5938 Query: 486 DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLP-RLTTPPEPRP 544 D L +W L ++ + + L + E + + D+ + I K + +L+ PEP Sbjct: 5939 D-LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ---SISTKMEAIELKLSESPEPGR 5994 Query: 545 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 576 S S +A ++ +L ++ +LQ A+ Sbjct: 5995 SPESQMAEHQALMDEILMLQDEINELQSSLAE 6026 Score = 50.1 bits (118), Expect = 7e-06 Identities = 121/574 (21%), Positives = 226/574 (39%), Gaps = 79/574 (13%) Query: 50 KPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQ-SFAELDKKLLHMESQ 108 +P L S KLG++++ W L++ K R L+EA + Q Q S + K+ +E + Sbjct: 5926 EPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELK 5985 Query: 109 L-QDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQN 167 L + +PG + SQ+ + Q++ ++ E+ ELQ+ A L S E Q Sbjct: 5986 LSESPEPG---RSPESQMAEHQALMDEILMLQDEINELQSSLAE-ELVSESCEADPAEQL 6041 Query: 168 AVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG----- 222 A+ L L E + R + AS + + L+D+L ++R A+Q R Sbjct: 6042 ALQSTLTVLAERMSTIR--MKASGKRQLLEEKLNDQLE--EQRQEQALQRYRCEADELDS 6097 Query: 223 --------LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASL-------------- 260 L K+ + ++ L E+ ++ AL+ L Sbjct: 6098 WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAH 6157 Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQ-QVLDAAFQVEQYYFDVAEVEAWLGEQELL 319 EAE + L +L+ + L+ A +Q + A + E+ D+ ++ G QE L Sbjct: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWL 6216 Query: 320 MMSEDK-GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQ 378 + + QS+LQ K +LEQ + + + ++ + +L + H +E Sbjct: 6217 AQARTTWTQQRQSSLQQQK---ELEQELAEQKSLLRSVASRGEEIL-IQHSAAETSGDAG 6272 Query: 379 SQVDRLYVALKELGEERRV---------ALEQQY-----WLYQLSRQVSELEHWIAEKEV 424 + D L L GE+ +L Q++ L + Q E + + Sbjct: 6273 EKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRL 6332 Query: 425 VAGSPELGQDF---------EHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH 475 ++G P D + L + F E +S++G A R+ + ++ D G Sbjct: 6333 LSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYD-----GV 6387 Query: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 535 +A +T W D + E L+ + ++E+ D +E+ ++++ + + Sbjct: 6388 SATST---WLDDVEERLFVATALLPEETETCLFNQEI--LAKDIKEMSEEMDKNKNLFSQ 6442 Query: 536 LTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQ 569 PE + ++ TL L LL S V Q Sbjct: 6443 AF--PENGDNRDVIEDTLGCLLGRLSLLDSVVNQ 6474 Score = 46.6 bits (109), Expect = 8e-05 Identities = 138/758 (18%), Positives = 276/758 (36%), Gaps = 151/758 (19%) Query: 11 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQ---QLMQEKPELAASVRKK---LGEI 64 D HK + + L + E K +++E Q +LM + + K+ L I Sbjct: 6628 DKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYI 6687 Query: 65 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL-------HMESQLQDVDPG-- 115 + W+ L+ Q +RQL + V E + +L+ H++S L + P Sbjct: 6688 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLY 6747 Query: 116 -------------------------GD--LATVNSQLKKLQSMESQVEEWYREVGE---- 144 G+ L+ N K+L +E+ ++ W R E Sbjct: 6748 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 6807 Query: 145 ----------LQAQTAALPLEPASKELVGERQNA--------------------VGERLV 174 L+ T P E+V + NA G +L+ Sbjct: 6808 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867 Query: 175 RL-----------LEPLQERRRLLLAS-----KELHQVA-------HDLDDELAWVQERL 211 RL L + + LL + ++LHQ+ H + + ++W+ + Sbjct: 6868 RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWIS-LM 6926 Query: 212 PLAMQTERGN-----GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE 266 +Q + N G +A+ ++++K +G + +I ++ V + ++ + S + E Sbjct: 6927 ENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQ---SVLQISSQDVE 6983 Query: 267 AVRRG-------LEQLQSAWAGLREAAERRQQVLDAAFQV-EQYYFDVAEVEAWLGEQEL 318 + R L + +W L+ + Q+L+ + +Y +V ++ W QE Sbjct: 6984 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 7043 Query: 319 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQI---- 374 + + + D+ S LK LE ++ E+ + ++ + AL++ D I Sbjct: 7044 RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 7103 Query: 375 --------SRRQSQVDRLYVALKELGEE---RRVALEQQYWLYQLSRQVSELEHWIAEKE 423 + V +L + LK + ++ +VA ++ ++ + E + ++ Sbjct: 7104 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK------INSYLMEARYSLSRFR 7157 Query: 424 VVAGSPELGQ-DFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 482 ++ GS E Q +++ LQ+ + G + NQ+ L EC T+ Sbjct: 7158 LLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFG----SITNQL---LKECHPPVTETLT 7210 Query: 483 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSD-ARELQGQIEEKRRRLPRLTTPPE 541 +N W LLE + + Q A +L + + D +++ ++++ R L Sbjct: 7211 NTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAAT 7270 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQ----LQEGAAQLRTVYAGEHAEAIASREQEVL 597 + A T +DL + V+ L E QL+ A AI S + + Sbjct: 7271 NKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS 7330 Query: 598 QGWKELLSA-CEDARLHVSSTADALRFHSQVRDLLSWM 634 Q L A C+ + D F + L +W+ Sbjct: 7331 QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 7368 Score = 44.7 bits (104), Expect = 3e-04 Identities = 122/621 (19%), Positives = 244/621 (39%), Gaps = 75/621 (12%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQE-KPELAASVRKKLGEIRQCWAELESTTQAKAR 80 H+ F AE+ ++ L I +GQ+L+++ + + KL + W + Q + Sbjct: 7497 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7556 Query: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 + + Q + AE +K L S L P L +V L++ +++ +V+ ++ Sbjct: 7557 IIDSQIRQWQRYREMAEKLRKWLVEVSYL----PMSGLGSVPIPLQQARTLFDEVQ--FK 7610 Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER-----RRLLLASKELHQ 195 E L+ Q + + A K+L+ + L L +QE+ RL K+L Sbjct: 7611 EKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF 7670 Query: 196 VAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAG 255 + D + + + L ++T + Q++ H E+ A R +E+ G Sbjct: 7671 LLKDWEKCEKGIADSLE-KLRTFKKKLSQSLPDH-------HEELHAEQMRCKELENAVG 7722 Query: 256 A---------------LASLRSPEAEAVRRGLEQLQSAWAGL-REAAERRQQVLDAAFQV 299 + A + + + + +E LQ W L + + RRQQ+ + + Sbjct: 7723 SWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEW 7782 Query: 300 EQYYFDVAEVEAWLGEQE----------LLMMSEDKGKDEQSTLQLLKKH-LQLEQGVEN 348 + E+ WL + E + M E KD Q + + +++ +QL+Q Sbjct: 7783 AVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQ---- 7838 Query: 349 YEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQL 408 E +A+ S + +A E+ + + R Q +D + +K+L +E VA++ QL Sbjct: 7839 MGERLAKASHESKA-SEIEYKLGKVNDRWQHLLDLIAARVKKL-KETLVAVQ------QL 7890 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS--------ETGMAGRERL 460 + +S L W+A E P + D + +Q K +E TG+A L Sbjct: 7891 DKNMSSLRTWLAHIESELAKP-IVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL 7949 Query: 461 AAVNQMVDELIECGHTAAA-TMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKFFSD 518 V ++ + C A ++ + L+ W + + M R ++ R KF D Sbjct: 7950 CEV--LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 8007 Query: 519 ARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLR 578 + ++ R ++ A + AF+ + ++Q+ + + Q R Sbjct: 8008 YSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINK---QYR 8064 Query: 579 TVYAGEHAEAIASREQEVLQG 599 + ++ S +Q V +G Sbjct: 8065 RLARENRTDSACSLKQMVHEG 8085 Score = 41.2 bits (95), Expect = 0.003 Identities = 85/402 (21%), Positives = 159/402 (39%), Gaps = 29/402 (7%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPEL-AASVRKKLGEIRQCWAELESTTQAKARQ 81 +AF E++ N +E+I +G+QL+++ L AA + ++L E+R+ E+ + ++ Sbjct: 8150 KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209 Query: 82 LFEASKADQLVQ-SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140 L D S EL+ + S L D D L +Q R Sbjct: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269 Query: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLAS--------- 190 + A ++PLE +L + ++A+ L E Q+ + L Sbjct: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS 8329 Query: 191 ---KELHQVAHDLDDELAWVQERLPLAM-QTERGNGLQAVQQHIKKNQGLRREIQAHGPR 246 ++ Q+ LDD +Q+ + +T G L + K G R Sbjct: 8330 ALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKR 8389 Query: 247 LEEVL----ERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQV-EQ 301 LE L E +L S E + + W L+ A ++ + Q +Q Sbjct: 8390 LEHKLKEEEESLPGFVNLHSTETQTAG-----VIDRWELLQAQALSKELRMKQNLQKWQQ 8444 Query: 302 YYFDVAEVEAWLG--EQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIAQLSR 358 + D+ + AWLG E+EL + + + T++L +KK +L++ V++ + I ++ Sbjct: 8445 FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINL 8504 Query: 359 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 400 + +S + R SQ++ + + L EE R L+ Sbjct: 8505 CSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQ 8546 Score = 40.4 bits (93), Expect = 0.005 Identities = 123/635 (19%), Positives = 232/635 (36%), Gaps = 99/635 (15%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQE-----KPELAASVRKKLGEIRQCWAELESTTQ 76 H+A M E+A ++ L ++ +G L+ + + +L +V L + ++ + ST Q Sbjct: 3966 HKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQ 4025 Query: 77 AKARQLFE-----ASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 131 + L S+ D L Q A L +E Q P A Q+K +++ Sbjct: 4026 RMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ---PPLSRAEAIKQVKHFRAL 4082 Query: 132 ESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASK 191 + Q Y ++ + ++ +K+ + + + + ++LV+ Q + Sbjct: 4083 QEQART-YLDLLCSMCDLSNASVKTTAKD-IQQTEQTIEQKLVQAQNLTQGWEEIKHLKS 4140 Query: 192 ELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVL 251 EL D D +L ++ R N + V+ +KK Q + + ++ Sbjct: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNT-------II 4193 Query: 252 ERAGALASLR-SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVE 310 E+ L SPE + + L W L + + Q + Y D V Sbjct: 4194 EKVNKLTKKEESPE----HKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4249 Query: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370 E+ D +ST L+ +L ++ + +I L Q Sbjct: 4250 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQ----------- 4298 Query: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430 +Q ++ L + KEL +E+ LEQ+++ +LE I K V+ + Sbjct: 4299 ------KQKMIEHLNLDDKELVKEQTSHLEQRWF---------QLEDLIKRKIQVSVT-- 4341 Query: 431 LGQDFEHVSVLQEKFS---EFASETGMAGRERL-------AAVNQMVDELIECGHTAAAT 480 + E ++V+Q +F E+A E E L A N ++D L C A Sbjct: 4342 ---NLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398 Query: 481 M---AEWKD--------GLNEAWAE-------------LLELMGTRAQLL-AASRELHKF 515 M + KD GLNE L +L+G R + L A E +F Sbjct: 4399 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQF 4458 Query: 516 FSDARELQGQIEEKRRRL---PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQE 572 + QI++ R++ + P+ S +T ++ + L+ ++V L Sbjct: 4459 LMAVFQATSQIQQHERKIMFREHICLLPD---DVSKQVKTCKSAQASLKTYQNEVTGLWA 4515 Query: 573 GAAQLRTVYAGEHAEAIASREQEVLQGWKELLSAC 607 +L + + + QE+ + +L C Sbjct: 4516 QGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC 4550 Score = 40.4 bits (93), Expect = 0.005 Identities = 67/303 (22%), Positives = 123/303 (40%), Gaps = 24/303 (7%) Query: 33 KEWLEKIEREGQQLMQEKPELAAS-VRKKLGEIRQCWAELESTTQAKARQLFEASKADQ- 90 K+ L + G+QL Q+ AAS ++ + Q LE K + +A D Sbjct: 7297 KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQAL-CKQQTSLQAGVLDYE 7355 Query: 91 -LVQSFAELDKKLLHMESQLQDVDPG--GDLATVNSQLKKLQSMESQVEEWYREVGELQA 147 +S L+ ++ E LQ DP DL+T+ ++++L+ + ++ L Sbjct: 7356 TFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE 7415 Query: 148 QTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWV 207 LPL KE+ +R + + ER L + HQ L+ W+ Sbjct: 7416 LGYRLPLN--DKEI--KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF--LEKCETWM 7469 Query: 208 QERLPLAMQTERGNGLQAV--QQHIKKNQGLRREIQAHGPRLEEVL-----ERAGALASL 260 + +QTE+ ++ QH+ + Q QA +++L + L Sbjct: 7470 E----FLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG 7525 Query: 261 RSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQELL 319 + + + L L + W G+ A++R+ ++D+ + Q Y ++AE + WL E L Sbjct: 7526 QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYL 7585 Query: 320 MMS 322 MS Sbjct: 7586 PMS 7588 Score = 38.9 bits (89), Expect = 0.016 Identities = 100/569 (17%), Positives = 219/569 (38%), Gaps = 98/569 (17%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82 Q A+L Q E ++I + +++ + V K + +I + ++E + A+ Sbjct: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ-- 2332 Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142 ++ + ++ ++ K+L +S + +NS +K S E + + Sbjct: 2333 ---NETCEALKKVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELE------SL 2378 Query: 143 GELQAQTAALPLEPASKELVGERQNAVGERLVR-LLEPLQERRRLLLASKELHQVAHDLD 201 G +A T + A +L + Q ++ E L + E +QE + L +K + + D Sbjct: 2379 G--RAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRT 2436 Query: 202 DELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLR 261 + ++ +L + LQ + + Q + G L L + + Sbjct: 2437 GDSKVLEAKL---------HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSK-----QIV 2482 Query: 262 SPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM 321 S E + + E+ Q A L++ + +Q + D A ++ + ++ W+ E E Sbjct: 2483 SSIQEQITKANEEFQ---AFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFN 2539 Query: 322 SEDKGKDEQSTLQLLKKHLQLEQGVENY---EESIAQLSRQCRALLEMGHPDSEQISRRQ 378 +E+ G+ +Q + + ++E + ES+ +LS++ + L E GH ++ R Sbjct: 2540 TENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQE-GRLC 2598 Query: 379 SQVDRLYVALKELGEER----RVALEQQYWLYQLSRQ----VSELEHWIAEKEVVAGSPE 430 SQ+ + L + +E+ +VAL++ L + + V ++ +A E GS + Sbjct: 2599 SQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKD 2658 Query: 431 -LGQDFEHVSVLQEKFSEFASETGMA---GRERLAAVNQ-------------------MV 467 L + + + E + MA G + L + N+ ++ Sbjct: 2659 TLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIM 2718 Query: 468 DELIECGHTAAATMAEWKD---------------------------GLNEAWAELLELMG 500 + T + +++W D GL E + L L Sbjct: 2719 SSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQS 2778 Query: 501 TRAQLLAASRELHKFFSDARELQGQIEEK 529 ++ +R LH+ + +REL + E++ Sbjct: 2779 ILSEAEDHTRALHRLIAKSRELYEKTEDE 2807 Score = 37.0 bits (84), Expect = 0.060 Identities = 93/533 (17%), Positives = 203/533 (38%), Gaps = 46/533 (8%) Query: 117 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVG--ERQNAVGERLV 174 +++ V++ L+K+Q S+ E ++ + ++ L ++ G + A E Sbjct: 3096 NISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWK 3155 Query: 175 RLLEPLQERRRLL----LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHI 230 L ++ L + K+ A + D L+ ++ + + + R L A ++ Sbjct: 3156 NFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHES--SNRLYDLPAKRREQ 3213 Query: 231 KKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQ 290 +K Q + EI + P+L + E+A L ++ +++ R + QL S + L + + Sbjct: 3214 QKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA-ASKSFRHRVSQLSSQYLALSNLTKEKV 3272 Query: 291 QVLD-AAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349 LD + Q+ + E++ W+ + ++ S ++S L L+ V+ Sbjct: 3273 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3332 Query: 350 EE-SIAQLSRQCRALLEMGHPDSEQISRRQSQ-VDRLYVALKELGEERRVALE---QQYW 404 +E + + + ++L+ P+ ++Q Q V ++ +L G + LE ++ Sbjct: 3333 KEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWT 3392 Query: 405 LYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVN 464 YQ V + W+ E +++ + + +E +T M G+ +L Sbjct: 3393 SYQ--DGVRQFSGWMDSMEA------------NLNESERQHAELRDKTTMLGKAKL---- 3434 Query: 465 QMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQG 524 ++E + + T+ G+ E + LEL + + A + + + +L Sbjct: 3435 --LNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVR 3492 Query: 525 QIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ----EGAAQLRTV 580 +E +R L L H + + +++LQ EG A L +V Sbjct: 3493 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3552 Query: 581 YAGEH---AEAIASREQEVL----QGWKELLSACEDARLHVSSTADALRFHSQ 626 I E L Q W+ + R ++ + LR Q Sbjct: 3553 LHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3605 Score = 35.8 bits (81), Expect = 0.13 Identities = 113/552 (20%), Positives = 214/552 (38%), Gaps = 90/552 (16%) Query: 10 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 69 E +++HK + F+ EL +E L+K+ + G QL+ E+ A + ++ Sbjct: 2552 EKKNEVHKV----EMFLGELLAARESLDKLSQRG-QLLSEEGHGAGQEGRLCSQLLTSHQ 2606 Query: 70 ELESTTQAKARQ----LFEASKADQLVQSF----AELDKKLLHMESQLQDVDPGGDLATV 121 L T+ K R L E ++ +QS + +L ES L G T+ Sbjct: 2607 NLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTL------GSKDTL 2660 Query: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 181 +L ++Q + E GE++ A E A + E Q + +L L E Sbjct: 2661 EKRLSQIQDILLMKGE-----GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWA 2715 Query: 182 E-RRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 + + A L V +D ER N L+ + + +Q + + Sbjct: 2716 DIMSSSVHAQSTLESVISQWND-------------YVERKNQLEQWMESV--DQKIEHPL 2760 Query: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300 Q P L+E L S+ S EAE R L +L + ++ E ++ D +F+ Sbjct: 2761 QPQ-PGLKEKFVLLDHLQSILS-EAEDHTRALHRL------IAKSRELYEKTEDESFK-- 2810 Query: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360 D A+ E +++ ++++K + + +++K HL V + + + + Sbjct: 2811 ----DTAQEELKTQFNDIMTVAKEKMRKVE---EIVKDHLMYLDAVHEFTDWLHSAKEEL 2863 Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420 +M DS ++ S++ L + +E+G R +E + + S E Sbjct: 2864 HRWSDMS-GDSSATQKKLSKIKEL-IDSREIGASRLSRVESLAPEVKQNTTASGCELMHT 2921 Query: 421 EKEVVAGSPELGQD--FEHVSVLQEKFSEFA-SETGMAGR--------ERLAAV------ 463 E + + + +D F+ S L+ S+ A SE +G+ E+ +A+ Sbjct: 2922 EMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQ 2981 Query: 464 -------NQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 516 +E++EC H E D L +A +L +L SR+L + Sbjct: 2982 QLTLLEGKNTDEEIVECWHKG----QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY- 3036 Query: 517 SDARELQGQIEE 528 + ++ G I+E Sbjct: 3037 --SGKVSGLIKE 3046 Score = 34.7 bits (78), Expect = 0.30 Identities = 111/623 (17%), Positives = 239/623 (38%), Gaps = 49/623 (7%) Query: 38 KIEREGQQLMQEKPELAASVRKKLGEIRQCWAELE----STTQAKARQLFEASKADQLVQ 93 +++R G +L E+P + ++L +++ + EL S + L S+ ++ +Q Sbjct: 6542 ELKRRGDKLQVEQPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6596 Query: 94 SFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 153 A+L +E+ + + GD + S +++Q + + +E+++ + T L Sbjct: 6597 DLADL------LETGQEKM--AGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLF 6648 Query: 154 LEPASKELVGERQ------NAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWV 207 + S + E Q L R + E +L L + +L +L V Sbjct: 6649 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV 6708 Query: 208 QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEA 267 + +P E + I Q L+ + + P+L +VL+ L L S Sbjct: 6709 ESSIPSVGLVEENE--DRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL--LISISCSD 6764 Query: 268 VRRGLEQLQSAWAGLREAAERRQQVLDAAFQV-EQYYFDVAEVEAWL-GEQELLMMSEDK 325 + L QL W + L+ + +Y + A++ WL ++ L + Sbjct: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ 6824 Query: 326 GKDEQSTLQLLKKHL----QLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQV 381 L++++ HL + + V+ + + LL + D+ + S++ Sbjct: 6825 SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRI 6884 Query: 382 DRLYVALKELGEERRVALEQQYWLYQLSRQ-VSELEHWIAEKEVVAGSPE------LGQD 434 D + L + L Q SR +SE+ WI+ E V E +G Sbjct: 6885 DSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG-- 6942 Query: 435 FEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAATMAEWKDGLNE 490 ++ + +K+ F + + + VNQ V ++ +E + AE +N+ Sbjct: 6943 YKAIHEYLQKYKGFKIDINCK-QLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNK 7001 Query: 491 AWAELLELMGTRAQLLAASRE-LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 549 +W L L+ + QLL E ++ ++ + L+ E + +RL + + + S + Sbjct: 7002 SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNA 7060 Query: 550 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACED 609 + + E ++ +V ++++ L + + + S +E+ Q W L Sbjct: 7061 LKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQ 7120 Query: 610 ARLHVSSTADALRFHSQVRDLLS 632 ++ + S D H D ++ Sbjct: 7121 LKILLKSVLDQWSSHKVAFDKIN 7143 Score = 33.1 bits (74), Expect = 0.86 Identities = 47/236 (19%), Positives = 102/236 (43%), Gaps = 20/236 (8%) Query: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81 ++ +M L + ++ ++R +L +E+ L V E Q ++ +A+ Sbjct: 8370 YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET-QTAGVIDRWELLQAQA 8428 Query: 82 LFEASKADQLVQSFAELDKKLLHMES----------QLQDVDPGGDLATVNSQLKKLQSM 131 L + + Q +Q + + + L + + QLQ ++ D+ T+ Q+KKL+ + Sbjct: 8429 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKEL 8488 Query: 132 ESQVEEWYREVGELQAQTAALPLEPA-SKEL--VGERQNAVGERLVRLLEPLQERRRL-- 186 + V+ +R+ L + A SKE + +R + + R R+ L+E R L Sbjct: 8489 QKAVD--HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQ 8546 Query: 187 --LLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240 L+ + H+++H L L + R + + + +Q H K+ ++ E+ Sbjct: 8547 DALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 8602 Score = 32.7 bits (73), Expect = 1.1 Identities = 92/467 (19%), Positives = 179/467 (38%), Gaps = 79/467 (16%) Query: 28 ELAQNKEWLEKIEREGQQLM---QEKPELAASVRKKLGEIRQCWAELESTTQAKA----- 79 +L + KE + E QQL+ +E + S LG+I + LE Q+ A Sbjct: 795 QLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQK 854 Query: 80 ------------RQLFEASKADQLVQSFAELDKKLLH-----MESQLQDVDPG------- 115 + L K Q VQ F L L H ++ Q+ D+ Sbjct: 855 HQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKK 914 Query: 116 -GD----LATVNSQLKKLQSMESQVEEWYREVGE-LQAQTAALPLEPASKELVGERQNAV 169 GD + T + +KK + +++E+ R E L+ + L E + V Sbjct: 915 TGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV 974 Query: 170 GERLVRLLE------PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 223 ++ + P QE++ L A ++LH+ DL E + L L + E+ L Sbjct: 975 LNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPY--HLLHLKIDVEKNRFL 1032 Query: 224 QAVQQ---------HIKKNQGLRREIQAH-------GPR--LEEVLERAGALASLRSPEA 265 +V++ + +G + I+ H GP E+ L+ L ++ P Sbjct: 1033 ASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELC-VKLPVR 1091 Query: 266 EAVRRGLEQLQSAWAGLREAAERR-QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMS-E 323 + VR LR A + +++++ + + Y +E +W+ E + + Sbjct: 1092 DPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIK 1151 Query: 324 DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 383 + D + ++ + ++ GV E+++ L + + L E+ + Q ++ ++ + Sbjct: 1152 GEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQ--KQGDELAK 1209 Query: 384 LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430 L + K L V L L ++ + +S + KE+V S E Sbjct: 1210 LSSSFKAL-----VTL-----LSEVEKMLSNFGDCVQYKEIVKNSLE 1246 >gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo sapiens] Length = 1939 Score = 77.0 bits (188), Expect = 5e-14 Identities = 139/658 (21%), Positives = 261/658 (39%), Gaps = 114/658 (17%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 ELA+ + +++E + LMQEK +L V+ AE +S A+ R Sbjct: 866 ELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ----------AEADSLADAEER------- 908 Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYREVGELQ 146 DQL+++ +L+ K+ + + +D + +N++L K + +E + E +++ +L+ Sbjct: 909 CDQLIKTKIQLEAKIKEVTERAEDEE------EINAELTAKKRKLEDECSELKKDIDDLE 962 Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206 A + E K + + E + L E + + + A +E HQ LDD Sbjct: 963 LTLAKVEKE---KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ--QTLDD---- 1013 Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE 266 LQA + + + +++ LE LE + + Sbjct: 1014 ----------------LQAEEDKVNTLTKAKIKLEQQVDDLEGSLE-----------QEK 1046 Query: 267 AVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMS-EDK 325 +R LE+ + G + A+ ++ +E D +++ L ++E M + K Sbjct: 1047 KIRMDLERAKRKLEGDLKLAQ------ESTMDIEN---DKQQLDEKLKKKEFEMSGLQSK 1097 Query: 326 GKDEQST-LQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQ 380 +DEQ+ +QL KK +L+ +E EE I + R RA E D E+IS R + Sbjct: 1098 IEDEQALGMQLQKKIKELQARIEELEEEI-EAERASRAKAEKQRSDLSRELEEISERLEE 1156 Query: 381 VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSV 440 A E+ ++R ++ + + E K+ ELG+ +++ Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1216 Query: 441 LQEKFSEFASETGMAGRE---RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLE 497 +++K + SE M + + V++ L + ++E K E + + Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIND 1276 Query: 498 LMGTRAQLLAASRELHKFFSDARELQG-----------QIEEKRRRLPRLTTPPEPRPSA 546 L RA+L S E + + L QIEE +R+L E + Sbjct: 1277 LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQL------EEEIKAK 1330 Query: 547 SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA----------IASREQEV 596 S++ L++ HD LL Q + QE A+L+ + ++E R +E+ Sbjct: 1331 SALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEEL 1390 Query: 597 LQGWKELLSACEDARLHV--------SSTADALRFHSQVRDLLSWMDGIASQIGAADK 646 + K+L +DA HV S R ++V DL+ ++ + A DK Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDK 1448 Score = 42.0 bits (97), Expect = 0.002 Identities = 106/551 (19%), Positives = 221/551 (40%), Gaps = 87/551 (15%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLM---QEKPELAASVRKK-------LGEIRQ----CW 68 +A A+ A ++ ++++ E + LM + A++ KK L E +Q Sbjct: 1409 EAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1468 Query: 69 AELEST---TQAKARQLFEASKA-DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQ 124 AELE++ +++ + +LF+ A ++ + L ++ +++ ++ D+ +A + Sbjct: 1469 AELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE--QIAEGGKR 1526 Query: 125 LKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERR 184 + +L+ ++ QVE+ E ELQA AL AS E E Sbjct: 1527 IHELEKIKKQVEQ---EKSELQA---ALEEAEASLE--------------------HEEG 1560 Query: 185 RLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHI-----KKNQGLRRE 239 ++L EL+QV ++D ++A E + M+ ++++Q + +N +R + Sbjct: 1561 KILRIQLELNQVKSEVDRKIAEKDEEID-QMKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1619 Query: 240 IQAHGPRLEEVLE-------RAGALASLRSPEA--EAVRRGLEQLQSAWAGLREA---AE 287 + G E ++ A AL + R+ +A + + L+ + L+E E Sbjct: 1620 KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVE 1679 Query: 288 RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVE 347 RR +L A + + + E + EQELL SE L+ +LE + Sbjct: 1680 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1739 Query: 348 NYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQ 407 + + + ++ R E + + + + +EL +E+ + + Sbjct: 1740 QIQGEMEDIIQEARNAEE----------KAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789 Query: 408 LSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAV---- 463 L + V +L+H + E E +A L + + L+ + E E + + AV Sbjct: 1790 LEQTVKDLQHRLDEAEQLA----LKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845 Query: 464 --NQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARE 521 + V EL + +D +++ A ++ + Q A + + S R Sbjct: 1846 KHERKVKELTYQTEEDRKNILRLQDLVDKLQA---KVKSYKRQAEEAEEQSNVNLSKFRR 1902 Query: 522 LQGQIEEKRRR 532 +Q ++EE R Sbjct: 1903 IQHELEEAEER 1913 >gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo sapiens] Length = 1940 Score = 75.1 bits (183), Expect = 2e-13 Identities = 135/657 (20%), Positives = 263/657 (40%), Gaps = 112/657 (17%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEA-S 86 ELA+++ +++E + L+QEK +L V QA++ L +A Sbjct: 863 ELAKSEAKRKELEEKLVTLVQEKNDLQLQV------------------QAESENLLDAEE 904 Query: 87 KADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYREVGEL 145 + DQL+++ +L+ K+ + + +D + +N++L K + +E + E +++ +L Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEE------EINAELTAKKRKLEDECSELKKDIDDL 958 Query: 146 QAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELA 205 + A + E K + + E L L E + + R A +E HQ A LDD Sbjct: 959 ELTLAKVEKE---KHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQA--LDD--- 1010 Query: 206 WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEA 265 LQA + + + +++ LE LE+ L + Sbjct: 1011 -----------------LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKL----RVDL 1049 Query: 266 EAVRRGLE-QLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 324 E +R LE L+ A + + +QQ LD + + + + + Sbjct: 1050 ERNKRKLEGDLKLAQESILDLENDKQQ-LDERLKKKDFEY---------------CQLQS 1093 Query: 325 KGKDEQST-LQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQS 379 K +DEQ+ LQ KK +L+ +E EE I + R RA E D E++S R Sbjct: 1094 KVEDEQTLGLQFQKKIKELQARIEELEEEI-EAERATRAKTEKQRSDYARELEELSERLE 1152 Query: 380 QVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEH----WIAEKEVVAGSPELGQDF 435 + + EL ++R E ++ + + + L+H K+ ELG+ Sbjct: 1153 EAGGVTSTQIELNKKR----EAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI 1208 Query: 436 EHVSVLQEKFSEFASETGMAGRE---RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAW 492 +++ +++K + SE + + + +V++ L + T ++E + E Sbjct: 1209 DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ 1268 Query: 493 AELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTP-----PEPRPSAS 547 L EL +++L + EL + + + Q+ ++ + T E + + Sbjct: 1269 RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKN 1328 Query: 548 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA----------IASREQEVL 597 ++ L++ HD LL Q + QEG A+L+ + ++E R +E+ Sbjct: 1329 ALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELE 1388 Query: 598 QGWKELLSACEDARLHV--------SSTADALRFHSQVRDLLSWMDGIASQIGAADK 646 + K+L +D+ V S R +V DL+ ++ S A DK Sbjct: 1389 EAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 1445 Score = 59.3 bits (142), Expect = 1e-08 Identities = 123/559 (22%), Positives = 220/559 (39%), Gaps = 100/559 (17%) Query: 26 MAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEA 85 +A+L + K+ L++ ++ +Q + + S+ K ++ Q +LES+ + + + + Sbjct: 990 IAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDL 1049 Query: 86 SKADQLVQSFAEL-DKKLLHMESQLQDVDPGGDLATVNSQLKKLQ----SMESQVEEWYR 140 + + ++ +L + +L +E+ Q +D +LKK ++S+VE+ Sbjct: 1050 ERNKRKLEGDLKLAQESILDLENDKQQLD---------ERLKKKDFEYCQLQSKVED--- 1097 Query: 141 EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ-ERRRLLLASKELHQVAHD 199 QT L + KEL R+ L E ++ ER K+ A + Sbjct: 1098 ------EQTLGLQFQKKIKELQA--------RIEELEEEIEAERATRAKTEKQRSDYARE 1143 Query: 200 LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQG-----LRREIQAHGPRLEEVLERA 254 L++ + ERL E G+ + Q + K + LRR+++ E L+ Sbjct: 1144 LEE----LSERL------EEAGGVTSTQIELNKKREAEFLKLRRDLE------EATLQHE 1187 Query: 255 GALASLRSPEAEAVRRGLEQ---LQSAWAGL-REAAERRQQVLDAAFQVEQYYFDVAEVE 310 +A+LR A++V EQ LQ L +E +E + ++ D + +E A +E Sbjct: 1188 AMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLE 1247 Query: 311 AWLGEQELLMMSEDKGKDEQ-----STLQLLKKHLQLEQG-----VENYEESIAQLSRQC 360 E +SE +GK+E+ S L K LQ E G +E E ++QLSR Sbjct: 1248 KICRTLED-QLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSK 1306 Query: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQ---------LSRQ 411 +A + Q+ + L AL+ + + L +QY Q LS+ Sbjct: 1307 QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL-LREQYEEEQEGKAELQRALSKA 1365 Query: 412 VSELEHWIAEKEVVA---------GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAA 462 SE+ W + E A +L Q + E + + + Sbjct: 1366 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGE 1425 Query: 463 VNQMVDELIECGHTAAA----------TMAEWKDGLNEAWAELLELMGTRAQLLAASREL 512 V ++ ++ AAA +AEWK E+ AEL + L S EL Sbjct: 1426 VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSL---STEL 1482 Query: 513 HKFFSDARELQGQIEEKRR 531 K + E Q+E +R Sbjct: 1483 FKLKNAYEEALDQLETVKR 1501 Score = 49.7 bits (117), Expect = 9e-06 Identities = 90/408 (22%), Positives = 167/408 (40%), Gaps = 56/408 (13%) Query: 36 LEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF 95 LE ++RE + L QE A + +++ E + ELE K+R+ E KAD + + Sbjct: 1496 LETVKRENKNLEQE----IADLTEQIAENGKTIHELE-----KSRKQIELEKAD-IQLAL 1545 Query: 96 AELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYREVGE-LQAQTAALP 153 E + L H E+++ + +L V S++ +K+ + ++E+ R ++ +AL Sbjct: 1546 EEAEAALEHEEAKILRIQL--ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603 Query: 154 LEPASK-ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERL- 211 E S+ E + ++ G+ ++ R+ K L V L D + + L Sbjct: 1604 AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALR 1663 Query: 212 -------PLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE 264 LA+ R N LQA + ++ L + +A +E+L+ + L + Sbjct: 1664 GQEDLKEQLAIVERRANLLQAEVEELRAT--LEQTERARKLAEQELLDSNERVQLLHTQN 1721 Query: 265 AEAVRR------GLEQLQS----AWAGLREAAER-RQQVLDAAFQVEQYYFD-------- 305 + L QLQS A R A E+ ++ + DAA E+ + Sbjct: 1722 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1781 Query: 306 ---------VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 356 V +++ L E E L + K + ++ ++ + +LE + ES+ L Sbjct: 1782 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGL 1841 Query: 357 ---SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401 R+ + L D + + R Q VD+L V +K + A EQ Sbjct: 1842 RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQ 1889 Score = 48.1 bits (113), Expect = 3e-05 Identities = 94/437 (21%), Positives = 169/437 (38%), Gaps = 70/437 (16%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLM---QEKPELAASVRKKLGEIRQCWAELESTTQAKA 79 +A A+ A ++ ++++ E + LM + LAA++ KK + AE ++ + Sbjct: 1406 EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQ 1465 Query: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQS----MESQV 135 +L + K + + + EL K E L ++ TV + K L+ + Q+ Sbjct: 1466 AELEASLKESRSLST--ELFKLKNAYEEALDQLE------TVKRENKNLEQEIADLTEQI 1517 Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQ 195 E + + EL+ + LE A +L E A E E ++L EL Q Sbjct: 1518 AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEH---------EEAKILRIQLELTQ 1568 Query: 196 VAHDLDDELAWVQERLPL--------------AMQTERGNGLQAVQQHIKKNQGLRREIQ 241 V ++D ++A E + A+ E + +A++ KK +G EI+ Sbjct: 1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLK-KKMEGDLNEIE 1627 Query: 242 ---AHGPRLEEVLERAGALASLRSPEAEA---------VRRGLEQLQSAWAGLREAAERR 289 +H R + A L LRS + + RG E L+ A ERR Sbjct: 1628 IQLSHANR-----QAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLA----IVERR 1678 Query: 290 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349 +L A + + + E L EQELL +E L+ +LE + Sbjct: 1679 ANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQL 1738 Query: 350 EESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLS 409 + + SR R E + + + + +EL +E+ + + L Sbjct: 1739 QSEVEDASRDARNAEE----------KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 1788 Query: 410 RQVSELEHWIAEKEVVA 426 + V +L+H + E E +A Sbjct: 1789 QTVKDLQHRLDEAEQLA 1805 >gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo sapiens] Length = 1939 Score = 74.7 bits (182), Expect = 3e-13 Identities = 132/642 (20%), Positives = 256/642 (39%), Gaps = 112/642 (17%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 ELA+ + +++E + LMQEK +L V+ AE ++ A+ R Sbjct: 866 ELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ----------AEADALADAEER------- 908 Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYREVGELQ 146 DQL+++ +L+ K+ + + +D + +N++L K + +E + E +++ +L+ Sbjct: 909 CDQLIKTKIQLEAKIKEVTERAEDEE------EINAELTAKKRKLEDECSELKKDIDDLE 962 Query: 147 AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAW 206 A + E K + + E + L E + + + A +E HQ LDD Sbjct: 963 LTLAKVEKE---KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ--QTLDD---- 1013 Query: 207 VQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE 266 L M+ ++ N L + +++ LE LE+ L + E Sbjct: 1014 ------LQMEEDKVNTLTKA----------KTKLEQQVDDLEGSLEQEKKLCM----DLE 1053 Query: 267 AVRRGLE-QLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 +R LE L+ A + +QQ+ + ++++ F+++ ++ + +++ L Sbjct: 1054 RAKRKLEGDLKLAQESTMDTENDKQQLNE---KLKKKEFEMSNLQGKIEDEQAL------ 1104 Query: 326 GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQV 381 +QL KK +L+ +E EE I + R RA E D E+IS R + Sbjct: 1105 ------AIQLQKKIKELQARIEELEEEI-EAERASRAKAEKQRSDLSRELEEISERLEEA 1157 Query: 382 DRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL 441 A E+ ++R ++ + S E K+ ELG+ + + + Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRV 1217 Query: 442 QEKFSEFASETGMAGRE---RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL 498 ++K + SE M + + V++ + T ++E K E + EL Sbjct: 1218 KQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINEL 1277 Query: 499 MGTRAQLLAASRELHKFFSD-----------ARELQGQIEEKRRRLPRLTTPPEPRPSAS 547 +A+L S E + + + QIEE +R+L E + S Sbjct: 1278 SAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL------EEETKAKS 1331 Query: 548 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA----------IASREQEVL 597 ++ L++ HD LL Q + QE A+L+ + ++E R +E+ Sbjct: 1332 TLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELE 1391 Query: 598 QGWKELLSACEDARLHVSSTADAL--------RFHSQVRDLL 631 + K+L +DA HV + R ++V DL+ Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLM 1433 Score = 47.4 bits (111), Expect = 4e-05 Identities = 102/525 (19%), Positives = 211/525 (40%), Gaps = 68/525 (12%) Query: 39 IEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK--------ADQ 90 + + ++ + K EL + K E+ Q + E+ + +L EA K A++ Sbjct: 1347 LREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1406 Query: 91 LVQSF----AELDKKLLHMESQLQD--VDPGGDLATVNSQLKKLQSMESQVEEWYREVGE 144 V++ A L+K ++++++D +D A + KK ++ + + EW ++ E Sbjct: 1407 HVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEE 1466 Query: 145 LQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDE 203 QA+ A E S + + +NA E L L L +K L Q DL ++ Sbjct: 1467 TQAELEASQKESRSLSTELFKVKNAYEESLDHL-------ETLKRENKNLQQEISDLTEQ 1519 Query: 204 LAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP 263 +A E G +HI + + +++++ L+ LE A ASL Sbjct: 1520 IA------------EGG-------KHIHELEKVKKQLDHEKSELQTSLEEAE--ASLEHE 1558 Query: 264 EAEAVRRGLEQLQSAWAGLREAAERRQ---QVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320 E + +R LE Q R+ AE+ + Q+ +V + + E L + Sbjct: 1559 EGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRI 1618 Query: 321 MSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380 + +G + +QL + Q + + N + L + + L+ + + + + Sbjct: 1619 KKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGIL-KDTQLHLDDAIRGQDDLKEQLAM 1677 Query: 381 VDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV----------VAGSPE 430 V+R ++ EE R +LE+ + R+++E E A + V + + Sbjct: 1678 VERRANLMQAEVEELRASLERT----ERGRKMAEQELLDASERVQLLHTQNTSLINTKKK 1733 Query: 431 LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ--MVDELIECGHTAAATMAEWKDGL 488 L D +S +Q + + E A + A+ M+ E ++ +A + K + Sbjct: 1734 LETD---ISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1790 Query: 489 NEAWAELLELMGTRAQLL--AASRELHKFFSDARELQGQIEEKRR 531 + +L + QL +++ K + REL+ ++E +++ Sbjct: 1791 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQK 1835 Score = 36.2 bits (82), Expect = 0.10 Identities = 94/452 (20%), Positives = 182/452 (40%), Gaps = 71/452 (15%) Query: 59 KKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL 118 K L E +Q + E ++ +A ++ S + +L + ++ L H+E+ L Sbjct: 1455 KVLAEWKQKYEETQAELEASQKE--SRSLSTELFKVKNAYEESLDHLET----------L 1502 Query: 119 ATVNSQLKK-LQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLL 177 N L++ + + Q+ E + + EL+ L E + + E A E Sbjct: 1503 KRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEH----- 1557 Query: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQ--------QH 229 E ++L EL+QV ++D ++A E L Q +R N L+ V+ + Sbjct: 1558 ----EEGKILRIQLELNQVKSEIDRKIAEKDEELD---QLKR-NHLRVVESMQSTLDAEI 1609 Query: 230 IKKNQGLRREIQAHGPRLEEVLE-------RAGALASLRSPEA---------EAVRRGLE 273 +N LR + + G E ++ A AL +LR+ + + RG + Sbjct: 1610 RSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQD 1669 Query: 274 QLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTL 333 L+ A ERR ++ A + + + E + EQELL SE Sbjct: 1670 DLKEQLA----MVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNT 1725 Query: 334 QLLKKHLQLEQGVENYE---ESIAQLSRQCRALLEMGHPD----SEQISRRQ---SQVDR 383 L+ +LE + + E I Q +R + D +E++ + Q + ++R Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785 Query: 384 LYVALKELGEERRVALE--QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL 441 + +++ ++ ++ L+ +Q L +Q+ +LE + E E S E + E V L Sbjct: 1786 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVES-EQKHNVEAVKGL 1844 Query: 442 ---QEKFSEFASETGMAGRERLAAVNQMVDEL 470 + + E +T R+ + + +VD+L Sbjct: 1845 RKHERRVKELTYQT-EEDRKNILRLQDLVDKL 1875 >gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo sapiens] Length = 1941 Score = 73.9 bits (180), Expect = 4e-13 Identities = 136/663 (20%), Positives = 263/663 (39%), Gaps = 114/663 (17%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82 Q ELA+++ +++E + L++EK +L V+ AE E A+ R Sbjct: 863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ----------AEAEGLADAEER-- 910 Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYRE 141 DQL+++ +L+ K+ + + +D + +N++L K + +E + E ++ Sbjct: 911 -----CDQLIKTKIQLEAKIKEVTERAEDEE------EINAELTAKKRKLEDECSELKKD 959 Query: 142 VGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLD 201 + +L+ A + E K + + E + L E + + + A +E HQ LD Sbjct: 960 IDDLELTLAKVEKE---KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ--QTLD 1014 Query: 202 DELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLR 261 D LQA + + + +++ LE LE+ L Sbjct: 1015 D--------------------LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-- 1052 Query: 262 SPEAEAVRRGLE-QLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320 + E +R LE L+ A + + +QQ+ + ++++ F+++ +++ Sbjct: 1053 --DLERAKRKLEGDLKLAQESIMDIENEKQQLDE---KLKKKEFEISNLQS--------- 1098 Query: 321 MSEDKGKDEQST-LQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQIS 375 K +DEQ+ +QL KK +L+ +E EE I + R RA E D E+IS Sbjct: 1099 ----KIEDEQALGIQLQKKIKELQARIEELEEEI-EAERASRAKAEKQRSDLSRELEEIS 1153 Query: 376 RRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDF 435 R + A E+ ++R ++ + + E K+ ELG+ Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213 Query: 436 EHVSVLQEKFSEFASETGMAGRE---RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAW 492 +++ +++K + SE M + + V++ L + T ++E K E Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273 Query: 493 AELLELMGTRAQLLAASRELHKFFSDARELQG-----------QIEEKRRRLPRLTTPPE 541 + +L R +L S E + + L QIEE +R+L E Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL------EE 1327 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA----------IAS 591 + +++ L++ HD LL Q + QE A+L+ + + E Sbjct: 1328 EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQ 1387 Query: 592 REQEVLQGWKELLSACEDARLHV--------SSTADALRFHSQVRDLLSWMDGIASQIGA 643 R +E+ + K+L + A HV S R ++V DL+ ++ + A Sbjct: 1388 RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA 1447 Query: 644 ADK 646 DK Sbjct: 1448 LDK 1450 Score = 57.0 bits (136), Expect = 6e-08 Identities = 107/539 (19%), Positives = 221/539 (41%), Gaps = 74/539 (13%) Query: 29 LAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK- 87 L ++ + + + ++ + K EL ++ K E+ Q + E+ + +L EA K Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398 Query: 88 -------ADQLVQSF----AELDKKLLHMESQLQDV--DPGGDLATVNSQLKKLQSMESQ 134 A++ V++ A L+K ++++++D+ D A + KK ++ + Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI 1458 Query: 135 VEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLL----EPLQERRRLLLAS 190 + EW ++ E A+ LE + KE ++G L ++ E L + L + Sbjct: 1459 LAEWKQKCEETHAE-----LEASQKEA-----RSLGTELFKIKNAYEESLDQLETLKREN 1508 Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 K L Q DL +++A E G + +++ K+ + + E+QA LEE Sbjct: 1509 KNLQQEISDLTEQIA------------EGGKRIHELEKIKKQVEQEKCELQA---ALEE- 1552 Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA---FQVEQYYFDVA 307 A ASL E + +R LE Q R+ AE+ +++ ++ + Sbjct: 1553 -----AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL 1607 Query: 308 EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG 367 + E + + + +G + +QL + + + NY + L + + L+ Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL-KDTQIHLDDA 1666 Query: 368 HPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV--- 424 E + + + V+R L+ EE R LEQ + SR+++E E A + V Sbjct: 1667 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT----ERSRKIAEQELLDASERVQLL 1722 Query: 425 -------VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ--MVDELIECGH 475 + +L D +S +Q + + E A + A+ M+ E ++ Sbjct: 1723 HTQNTSLINTKKKLETD---ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779 Query: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLL--AASRELHKFFSDARELQGQIEEKRRR 532 +A + K + + +L + QL +++ K + REL+G++E +++R Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1838 Score = 34.7 bits (78), Expect = 0.30 Identities = 103/498 (20%), Positives = 209/498 (41%), Gaps = 81/498 (16%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLM---QEKPELAASVRKK-------LGEIRQ----CW 68 +A A+ A ++ ++++ E + LM + A++ KK L E +Q Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470 Query: 69 AELESTTQAKAR----QLFEASKA-DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNS 123 AELE++ Q +AR +LF+ A ++ + L ++ +++ ++ D+ +A Sbjct: 1471 AELEAS-QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE--QIAEGGK 1527 Query: 124 QLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183 ++ +L+ ++ QVE+ E ELQA AL AS E E Sbjct: 1528 RIHELEKIKKQVEQ---EKCELQA---ALEEAEASLE--------------------HEE 1561 Query: 184 RRLLLASKELHQVAHDLDDELAWVQE----------RLPLAMQTERGNGLQAVQQHIKKN 233 ++L EL+QV ++D ++A E R+ +MQ+ +++ I+ Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1621 Query: 234 QGLRREIQAHGPRLEEVLERAG-ALASLRSPEA--EAVRRGLEQLQSAWAGLREA---AE 287 + + ++ +L A AL + R+ + + + L+ + L+E E Sbjct: 1622 KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVE 1681 Query: 288 RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVE 347 RR +L A + + + E + EQELL SE L+ +LE + Sbjct: 1682 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1741 Query: 348 NYE---ESIAQLSRQCRALLEMGHPD----SEQISRRQ---SQVDRLYVALKELGEERRV 397 + E I Q +R + D +E++ + Q + ++R+ +++ ++ ++ Sbjct: 1742 QMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQL 1801 Query: 398 ALE--QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL---QEKFSEFASET 452 L+ +Q L +Q+ +LE + E E S E ++ E V L + + E +T Sbjct: 1802 RLDEAEQLALKGGKKQIQKLEARVRELEGEVES-EQKRNAEAVKGLRKHERRVKELTYQT 1860 Query: 453 GMAGRERLAAVNQMVDEL 470 R+ + + +VD+L Sbjct: 1861 -EEDRKNILRLQDLVDKL 1877 >gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo sapiens] Length = 1941 Score = 73.9 bits (180), Expect = 4e-13 Identities = 136/663 (20%), Positives = 263/663 (39%), Gaps = 114/663 (17%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82 Q ELA+++ +++E + L++EK +L V+ AE E A+ R Sbjct: 863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQ----------AEAEGLADAEER-- 910 Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL-KKLQSMESQVEEWYRE 141 DQL+++ +L+ K+ + + +D + +N++L K + +E + E ++ Sbjct: 911 -----CDQLIKTKIQLEAKIKEVTERAEDEE------EINAELTAKKRKLEDECSELKKD 959 Query: 142 VGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLD 201 + +L+ A + E K + + E + L E + + + A +E HQ LD Sbjct: 960 IDDLELTLAKVEKE---KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ--QTLD 1014 Query: 202 DELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLR 261 D LQA + + + +++ LE LE+ L Sbjct: 1015 D--------------------LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM-- 1052 Query: 262 SPEAEAVRRGLE-QLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLM 320 + E +R LE L+ A + + +QQ+ + ++++ F+++ +++ Sbjct: 1053 --DLERAKRKLEGDLKLAQESIMDIENEKQQLDE---KLKKKEFEISNLQS--------- 1098 Query: 321 MSEDKGKDEQST-LQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQIS 375 K +DEQ+ +QL KK +L+ +E EE I + R RA E D E+IS Sbjct: 1099 ----KIEDEQALGIQLQKKIKELQARIEELEEEI-EAERASRAKAEKQRSDLSRELEEIS 1153 Query: 376 RRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDF 435 R + A E+ ++R ++ + + E K+ ELG+ Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213 Query: 436 EHVSVLQEKFSEFASETGMAGRE---RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAW 492 +++ +++K + SE M + + V++ L + T ++E K E Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273 Query: 493 AELLELMGTRAQLLAASRELHKFFSDARELQG-----------QIEEKRRRLPRLTTPPE 541 + +L R +L S E + + L QIEE +R+L E Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL------EE 1327 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA----------IAS 591 + +++ L++ HD LL Q + QE A+L+ + + E Sbjct: 1328 EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQ 1387 Query: 592 REQEVLQGWKELLSACEDARLHV--------SSTADALRFHSQVRDLLSWMDGIASQIGA 643 R +E+ + K+L + A HV S R ++V DL+ ++ + A Sbjct: 1388 RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA 1447 Query: 644 ADK 646 DK Sbjct: 1448 LDK 1450 Score = 57.0 bits (136), Expect = 6e-08 Identities = 107/539 (19%), Positives = 221/539 (41%), Gaps = 74/539 (13%) Query: 29 LAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK- 87 L ++ + + + ++ + K EL ++ K E+ Q + E+ + +L EA K Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398 Query: 88 -------ADQLVQSF----AELDKKLLHMESQLQDV--DPGGDLATVNSQLKKLQSMESQ 134 A++ V++ A L+K ++++++D+ D A + KK ++ + Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI 1458 Query: 135 VEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLL----EPLQERRRLLLAS 190 + EW ++ E A+ LE + KE ++G L ++ E L + L + Sbjct: 1459 LAEWKQKCEETHAE-----LEASQKEA-----RSLGTELFKIKNAYEESLDQLETLKREN 1508 Query: 191 KELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 250 K L Q DL +++A E G + +++ K+ + + E+QA LEE Sbjct: 1509 KNLQQEISDLTEQIA------------EGGKRIHELEKIKKQVEQEKCELQA---ALEE- 1552 Query: 251 LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA---FQVEQYYFDVA 307 A ASL E + +R LE Q R+ AE+ +++ ++ + Sbjct: 1553 -----AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL 1607 Query: 308 EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG 367 + E + + + +G + +QL + + + NY + L + + L+ Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL-KDTQIHLDDA 1666 Query: 368 HPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV--- 424 E + + + V+R L+ EE R LEQ + SR+++E E A + V Sbjct: 1667 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT----ERSRKIAEQELLDASERVQLL 1722 Query: 425 -------VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ--MVDELIECGH 475 + +L D +S +Q + + E A + A+ M+ E ++ Sbjct: 1723 HTQNTSLINTKKKLETD---ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779 Query: 476 TAAATMAEWKDGLNEAWAELLELMGTRAQLL--AASRELHKFFSDARELQGQIEEKRRR 532 +A + K + + +L + QL +++ K + REL+G++E +++R Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1838 Score = 34.7 bits (78), Expect = 0.30 Identities = 103/498 (20%), Positives = 209/498 (41%), Gaps = 81/498 (16%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLM---QEKPELAASVRKK-------LGEIRQ----CW 68 +A A+ A ++ ++++ E + LM + A++ KK L E +Q Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470 Query: 69 AELESTTQAKAR----QLFEASKA-DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNS 123 AELE++ Q +AR +LF+ A ++ + L ++ +++ ++ D+ +A Sbjct: 1471 AELEAS-QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE--QIAEGGK 1527 Query: 124 QLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQER 183 ++ +L+ ++ QVE+ E ELQA AL AS E E Sbjct: 1528 RIHELEKIKKQVEQ---EKCELQA---ALEEAEASLE--------------------HEE 1561 Query: 184 RRLLLASKELHQVAHDLDDELAWVQE----------RLPLAMQTERGNGLQAVQQHIKKN 233 ++L EL+QV ++D ++A E R+ +MQ+ +++ I+ Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1621 Query: 234 QGLRREIQAHGPRLEEVLERAG-ALASLRSPEA--EAVRRGLEQLQSAWAGLREA---AE 287 + + ++ +L A AL + R+ + + + L+ + L+E E Sbjct: 1622 KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVE 1681 Query: 288 RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVE 347 RR +L A + + + E + EQELL SE L+ +LE + Sbjct: 1682 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1741 Query: 348 NYE---ESIAQLSRQCRALLEMGHPD----SEQISRRQ---SQVDRLYVALKELGEERRV 397 + E I Q +R + D +E++ + Q + ++R+ +++ ++ ++ Sbjct: 1742 QMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQL 1801 Query: 398 ALE--QQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVL---QEKFSEFASET 452 L+ +Q L +Q+ +LE + E E S E ++ E V L + + E +T Sbjct: 1802 RLDEAEQLALKGGKKQIQKLEARVRELEGEVES-EQKRNAEAVKGLRKHERRVKELTYQT 1860 Query: 453 GMAGRERLAAVNQMVDEL 470 R+ + + +VD+L Sbjct: 1861 -EEDRKNILRLQDLVDKL 1877 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 70.5 bits (171), Expect = 5e-12 Identities = 140/625 (22%), Positives = 248/625 (39%), Gaps = 59/625 (9%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 EL + E+ E + +Q +E L V+ + RQ EL S +A+A E + Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533 Query: 88 ADQLVQSFA----ELDKKLLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQV 135 A Q ++ E +++L E + L+ + A + S+ +Q+ Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQL 1592 Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELH 194 E +E AQ A ++ ER ER L R E RL L ++E+ Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652 Query: 195 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 254 Q E +E + QAV+Q Q L ++ Q ++ L Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712 Query: 255 GALASLRSP--EAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 312 L LR+ + E R+ LE+ + AA +++Q L+A ++A+V A Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---------ELAKVRA- 1762 Query: 313 LGEQELLMMSEDKGKDE-QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD- 370 E E+L+ S+ + ++E +ST + K+ L+ E G + E +A+ + + RAL E Sbjct: 1763 --EMEVLLASKARAEEESRSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQR 1817 Query: 371 ---SEQISRRQSQVDRLYVA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426 E +R++++ +R+ L +GE R+ E + L + + L +AE E Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQ 1876 Query: 427 GSPELGQDFEHVSVLQEKF--------SEFASETGMAGRERLAAVNQMVDELIECGHT-- 476 Q +H + ++E+ SE + G+ + L Q+ +E++ + Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFE 1935 Query: 477 -AAATMAEWKDGLNEAWA---------ELLELMGTRAQLLAASRELHKFFSDARELQGQI 526 AAA AE + L + E EL R + LAA E + ++ R + Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995 Query: 527 EEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586 E+ R E + ++ R E Q Q++ QE A + HA Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055 Query: 587 EAIASREQEVLQGWKELLSACEDAR 611 A+ +EQE+ Q ++ S + R Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLR 2080 Score = 64.7 bits (156), Expect = 3e-10 Identities = 131/640 (20%), Positives = 245/640 (38%), Gaps = 106/640 (16%) Query: 37 EKIEREGQQLMQEK---PELAASVRKK-LGEIRQCWAELESTTQAKARQLFEASKADQLV 92 E+ RE ++ +Q+ E AA RK L E+ + A++E + + R E+++ QL Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039 Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152 Q A+ +LQ + A + + Q+++ + + GE +A A Sbjct: 2040 QEAAQ---------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090 Query: 153 PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 212 E + ER+ A R V E L++ ++ Q A E+L Sbjct: 2091 E-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----------AEKLR 2139 Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS------LRSPEAE 266 + E QA Q +++ Q E++ H E+ L + + L+ E + Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199 Query: 267 AVRRGL-EQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 + L E+LQ A EAA +R QV + F V ++++++A + + ++ DK Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259 Query: 326 GKDEQSTLQLLKKHLQLEQGVENY--------------EESIAQ---------------- 355 ++ + +K Q+ + EE +AQ Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2319 Query: 356 -----LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE--LGEERRVALEQQYWLYQL 408 L + L + EQ R Q +++ L E G +R + E+Q L ++ Sbjct: 2320 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EM 2378 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468 S + L+ +AE E +D + E+ E T +A +E++ V + Sbjct: 2379 SAEAERLKLRVAEMSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436 Query: 469 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 528 + + H A + L EA AEL RE K +A+ LQ + EE Sbjct: 2437 QRQQSDHDA--------ERLREAIAEL-------------EREKEKLQQEAKLLQLKSEE 2475 Query: 529 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 588 + + Q ++F + L+ + R +++ A+L ++ E A+A Sbjct: 2476 MQ--------TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527 Query: 589 IASRE------QEVLQGWKELLSACEDARLHVSSTADALR 622 RE Q++ Q + L+++ E+AR + +R Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567 Score = 63.9 bits (154), Expect = 5e-10 Identities = 134/617 (21%), Positives = 247/617 (40%), Gaps = 51/617 (8%) Query: 9 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 68 +E + +R Q AE+ + + ++ E ++++ PE + + E+ Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTL 1071 Query: 69 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 128 +LE A L + +++ ++ L E QL++ V + L +L Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ------AVPATLPEL 1125 Query: 129 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGER-QNAVGERLVRL------LEPLQ 181 ++ ++ +++ + Q AL E + VGER Q GER V + + L Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185 Query: 182 ERRRLLLAS-----KELHQVAHDL-------DDELAWVQE--RLPLAMQTERGNGLQAVQ 227 ER + +LA +EL Q+ L D AW+Q+ R +Q QAV+ Sbjct: 1186 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1245 Query: 228 QHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLRE 284 + +++ Q L EI+ HG ++EE A + +++ E + V + LE + S A + Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPK 1304 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341 + V+ + +Y ++ + + + L M E++ EQ + ++ + Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401 +E +E + +A+ Q +A E + +Q R Q +V R A + +++R E+ Sbjct: 1365 VEAALEK-QRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE 1421 Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLA 461 L QL RQ SE E ++ A + E + V++ + + G A E L Sbjct: 1422 ---LQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQ 1476 Query: 462 AVNQMVDEL----IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517 A+ +E + A + +D +EL A+RE + Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536 Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577 EL+ Q EE RRL R R +++ R+ E +LQ S+ E AQL Sbjct: 1537 ALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAELQ---SKRASFAEKTAQL 1592 Query: 578 RTVYAGEHAEAIASREQ 594 EH RE+ Sbjct: 1593 ERSLQEEHVAVAQLREE 1609 Score = 61.6 bits (148), Expect = 2e-09 Identities = 160/718 (22%), Positives = 285/718 (39%), Gaps = 134/718 (18%) Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLE----KIEREGQQLMQEKPELAASVRKKL 61 +GT + + +R +A + Q ++ LE +++RE Q++ EL A Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA------ 1755 Query: 62 GEIRQCWAELESTTQAKARQLFE----ASKADQLVQS----FAELDKKLLHMESQLQDVD 113 E+ + AE+E +KAR E + K+ Q +++ F EL ++ + + ++ Sbjct: 1756 -ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814 Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERL 173 LA ++ ++ ++ E + E +GE A E A KE + A ERL Sbjct: 1815 RQRQLAEEDAARQRAEA-ERVLAEKLAAIGE--ATRLKTEAEIALKE-----KEAENERL 1866 Query: 174 VRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKN 233 RL E +RR L H+ D+++ LA Q R + ER GL V+ +++ Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKA--DIEERLA--QLRKASDSELERQKGL--VEDTLRQR 1920 Query: 234 QGLRREI--------QAHGPRLEEVLE----RAGALASLRSPE-------------AEAV 268 + + EI +A + E LE R+ A +LRS E AE Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980 Query: 269 RR---GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 RR E++Q + A EAA +R+ L+ +VE+ V E E ++ Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALE---EVERLKAKVEEARRLRERAE-----QES 2032 Query: 326 GKDEQSTLQLLKKHLQLEQ-----GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380 + Q + +K LQ E+ V+ E+ + Q +Q +++L+ ++E R + Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092 Query: 381 VDRLYV-----------------ALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423 + V LK+ EE+ A Q + R+ +E E A + Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---AARR 2149 Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH-------- 475 A L Q + EK +FA +T + + + +L E H Sbjct: 2150 AQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208 Query: 476 ---------TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL--------HKFFSD 518 AA ++ ++ L ++ EL +A++ A +R L +F + Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268 Query: 519 ARELQGQIEEKRRRL-------PRLTTPPE-----PRPSASSM-QRTLRAFEHDLQLLV- 564 E Q+ E+ RL RL E R A M + ++A + +L Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2328 Query: 565 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622 +++ Q Q+ AQ + E E +A + E QG++ L A +L +S+ A+ L+ Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386 Score = 58.9 bits (141), Expect = 1e-08 Identities = 130/625 (20%), Positives = 238/625 (38%), Gaps = 123/625 (19%) Query: 18 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 76 +W+RH E + E+IE Q ++ K EL A K + + LE Q Sbjct: 293 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 351 Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136 A ++ + + + +L +L E QL+ S+ ++L+ ++ V Sbjct: 352 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 399 Query: 137 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + E G + E+L + LQ RLL A K + Q Sbjct: 400 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 434 Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 254 A +++ +L + L N +Q ++ +H + Q RR + H ER Sbjct: 435 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 480 Query: 255 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313 L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+ Sbjct: 481 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 532 Query: 314 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373 E + + + G D S L H L Q +E + RA +E D Q Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 581 Query: 374 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425 +S ++D Y L + R +LE L+ ++ W+ EKE Sbjct: 582 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 636 Query: 426 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481 E+G D+ +++ +E +S E + +++ + D L+ H A T+ Sbjct: 637 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 693 Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541 ++ L W+ +L+L L + +FFSD RE +GQ+++ + L Sbjct: 694 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 745 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 598 R + T+ E LQ + QL E Y G H +A R + V+Q Sbjct: 746 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 796 Query: 599 --------GWKELLSACEDARLHVS 615 G LL+ C+ ++ V+ Sbjct: 797 RHPAHPMRGRLPLLAVCDYKQVEVT 821 Score = 52.4 bits (124), Expect = 1e-06 Identities = 107/433 (24%), Positives = 179/433 (41%), Gaps = 65/433 (15%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 +LAQ + EK+ +E Q +QE L A E+ Q EL Q +AR+L E Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAE-----AELLQQQKEL---AQEQARRLQE--D 2349 Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147 +Q+ Q AE E+Q G T+ ++ ++ M ++ E V E+ + Sbjct: 2350 KEQMAQQLAE--------ETQ-------GFQRTLEAERQRQLEMSAEAERLKLRVAEM-S 2393 Query: 148 QTAALPLEPASK-----ELVGE---RQNAVGERLVRLLEPLQERR--------RLLLASK 191 + A E A + E +GE R + V L++ L+ +R RL A Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453 Query: 192 ELHQVAHDLDDELAWVQ---ERLPLAMQTERGNGLQAVQQHI--KKNQGLRRE--IQAHG 244 EL + L E +Q E + Q + QA+QQ +K+ L+RE I+ Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513 Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304 +LE++ + A A E + ++ +EQ + E A RRQ +A V + Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH--EAEEGVRRKQE 2571 Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364 ++ ++E +QE L+ E++ EQ LQLL++ Q + + EE A + L Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQ--LQLLEE--QHRAALAHSEEVTASQVAATKTLP 2627 Query: 365 E----MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL----- 415 + P +E R V+ + L E ++ E+ L Q V EL Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2687 Query: 416 -EHWIAEKEVVAG 427 H++ + +AG Sbjct: 2688 VRHYLQGRSSIAG 2700 Score = 35.8 bits (81), Expect = 0.13 Identities = 69/272 (25%), Positives = 113/272 (41%), Gaps = 53/272 (19%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82 Q F E+A+ ++ E+ +R+ QQ+ QE+ L AS+ E R+ E E + K +L Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME----EARRRQHEAEEGVRRKQEEL 2573 Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142 QL Q + ++ L +L++ +LQ +E Q Sbjct: 2574 ------QQLEQQRRQQEELLAEENQRLRE---------------QLQLLEEQHRAALAHS 2612 Query: 143 GELQA-QTAALPLEPASKE-LVGERQNAVGERLVRLLEPLQERRRL----LLASKELHQV 196 E+ A Q AA P ++ L G A E L +RL +L+++EL ++ Sbjct: 2613 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2672 Query: 197 A--HDLDDELA-------WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 247 A H DELA ++Q R +A G L+A + + L+R++ + G L Sbjct: 2673 AQGHTTVDELARREDVRHYLQGRSSIA-----GLLLKATNEKLSVYAALQRQLLSPGTAL 2727 Query: 248 EEVLERAGALASLRSPEA-------EAVRRGL 272 +LE A L P EAV+ G+ Sbjct: 2728 -ILLEAQAASGFLLDPVRNRRLTVNEAVKEGV 2758 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 70.5 bits (171), Expect = 5e-12 Identities = 140/625 (22%), Positives = 248/625 (39%), Gaps = 59/625 (9%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 EL + E+ E + +Q +E L V+ + RQ EL S +A+A E + Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1537 Query: 88 ADQLVQSFA----ELDKKLLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQV 135 A Q ++ E +++L E + L+ + A + S+ +Q+ Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQL 1596 Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELH 194 E +E AQ A ++ ER ER L R E RL L ++E+ Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1656 Query: 195 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 254 Q E +E + QAV+Q Q L ++ Q ++ L Sbjct: 1657 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1716 Query: 255 GALASLRSP--EAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 312 L LR+ + E R+ LE+ + AA +++Q L+A ++A+V A Sbjct: 1717 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---------ELAKVRA- 1766 Query: 313 LGEQELLMMSEDKGKDE-QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD- 370 E E+L+ S+ + ++E +ST + K+ L+ E G + E +A+ + + RAL E Sbjct: 1767 --EMEVLLASKARAEEESRSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQR 1821 Query: 371 ---SEQISRRQSQVDRLYVA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426 E +R++++ +R+ L +GE R+ E + L + + L +AE E Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQ 1880 Query: 427 GSPELGQDFEHVSVLQEKF--------SEFASETGMAGRERLAAVNQMVDELIECGHT-- 476 Q +H + ++E+ SE + G+ + L Q+ +E++ + Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFE 1939 Query: 477 -AAATMAEWKDGLNEAWA---------ELLELMGTRAQLLAASRELHKFFSDARELQGQI 526 AAA AE + L + E EL R + LAA E + ++ R + Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999 Query: 527 EEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586 E+ R E + ++ R E Q Q++ QE A + HA Sbjct: 2000 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2059 Query: 587 EAIASREQEVLQGWKELLSACEDAR 611 A+ +EQE+ Q ++ S + R Sbjct: 2060 FAVQQKEQELQQTLQQEQSVLDQLR 2084 Score = 64.7 bits (156), Expect = 3e-10 Identities = 131/640 (20%), Positives = 245/640 (38%), Gaps = 106/640 (16%) Query: 37 EKIEREGQQLMQEK---PELAASVRKK-LGEIRQCWAELESTTQAKARQLFEASKADQLV 92 E+ RE ++ +Q+ E AA RK L E+ + A++E + + R E+++ QL Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043 Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152 Q A+ +LQ + A + + Q+++ + + GE +A A Sbjct: 2044 QEAAQ---------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094 Query: 153 PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 212 E + ER+ A R V E L++ ++ Q A E+L Sbjct: 2095 E-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----------AEKLR 2143 Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS------LRSPEAE 266 + E QA Q +++ Q E++ H E+ L + + L+ E + Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203 Query: 267 AVRRGL-EQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 + L E+LQ A EAA +R QV + F V ++++++A + + ++ DK Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2263 Query: 326 GKDEQSTLQLLKKHLQLEQGVENY--------------EESIAQ---------------- 355 ++ + +K Q+ + EE +AQ Sbjct: 2264 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2323 Query: 356 -----LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE--LGEERRVALEQQYWLYQL 408 L + L + EQ R Q +++ L E G +R + E+Q L ++ Sbjct: 2324 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EM 2382 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468 S + L+ +AE E +D + E+ E T +A +E++ V + Sbjct: 2383 SAEAERLKLRVAEMSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440 Query: 469 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 528 + + H A + L EA AEL RE K +A+ LQ + EE Sbjct: 2441 QRQQSDHDA--------ERLREAIAEL-------------EREKEKLQQEAKLLQLKSEE 2479 Query: 529 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 588 + + Q ++F + L+ + R +++ A+L ++ E A+A Sbjct: 2480 MQ--------TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531 Query: 589 IASRE------QEVLQGWKELLSACEDARLHVSSTADALR 622 RE Q++ Q + L+++ E+AR + +R Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571 Score = 63.9 bits (154), Expect = 5e-10 Identities = 134/617 (21%), Positives = 247/617 (40%), Gaps = 51/617 (8%) Query: 9 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 68 +E + +R Q AE+ + + ++ E ++++ PE + + E+ Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTL 1075 Query: 69 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 128 +LE A L + +++ ++ L E QL++ V + L +L Sbjct: 1076 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ------AVPATLPEL 1129 Query: 129 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGER-QNAVGERLVRL------LEPLQ 181 ++ ++ +++ + Q AL E + VGER Q GER V + + L Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1189 Query: 182 ERRRLLLAS-----KELHQVAHDL-------DDELAWVQE--RLPLAMQTERGNGLQAVQ 227 ER + +LA +EL Q+ L D AW+Q+ R +Q QAV+ Sbjct: 1190 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1249 Query: 228 QHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLRE 284 + +++ Q L EI+ HG ++EE A + +++ E + V + LE + S A + Sbjct: 1250 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPK 1308 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341 + V+ + +Y ++ + + + L M E++ EQ + ++ + Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1368 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401 +E +E + +A+ Q +A E + +Q R Q +V R A + +++R E+ Sbjct: 1369 VEAALEK-QRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE 1425 Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLA 461 L QL RQ SE E ++ A + E + V++ + + G A E L Sbjct: 1426 ---LQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQ 1480 Query: 462 AVNQMVDEL----IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517 A+ +E + A + +D +EL A+RE + Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540 Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577 EL+ Q EE RRL R R +++ R+ E +LQ S+ E AQL Sbjct: 1541 ALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAELQ---SKRASFAEKTAQL 1596 Query: 578 RTVYAGEHAEAIASREQ 594 EH RE+ Sbjct: 1597 ERSLQEEHVAVAQLREE 1613 Score = 61.6 bits (148), Expect = 2e-09 Identities = 160/718 (22%), Positives = 285/718 (39%), Gaps = 134/718 (18%) Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLE----KIEREGQQLMQEKPELAASVRKKL 61 +GT + + +R +A + Q ++ LE +++RE Q++ EL A Sbjct: 1706 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA------ 1759 Query: 62 GEIRQCWAELESTTQAKARQLFE----ASKADQLVQS----FAELDKKLLHMESQLQDVD 113 E+ + AE+E +KAR E + K+ Q +++ F EL ++ + + ++ Sbjct: 1760 -ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818 Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERL 173 LA ++ ++ ++ E + E +GE A E A KE + A ERL Sbjct: 1819 RQRQLAEEDAARQRAEA-ERVLAEKLAAIGE--ATRLKTEAEIALKE-----KEAENERL 1870 Query: 174 VRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKN 233 RL E +RR L H+ D+++ LA Q R + ER GL V+ +++ Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKA--DIEERLA--QLRKASDSELERQKGL--VEDTLRQR 1924 Query: 234 QGLRREI--------QAHGPRLEEVLE----RAGALASLRSPE-------------AEAV 268 + + EI +A + E LE R+ A +LRS E AE Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984 Query: 269 RR---GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 RR E++Q + A EAA +R+ L+ +VE+ V E E ++ Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALE---EVERLKAKVEEARRLRERAE-----QES 2036 Query: 326 GKDEQSTLQLLKKHLQLEQ-----GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380 + Q + +K LQ E+ V+ E+ + Q +Q +++L+ ++E R + Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096 Query: 381 VDRLYV-----------------ALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423 + V LK+ EE+ A Q + R+ +E E A + Sbjct: 2097 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---AARR 2153 Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH-------- 475 A L Q + EK +FA +T + + + +L E H Sbjct: 2154 AQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212 Query: 476 ---------TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL--------HKFFSD 518 AA ++ ++ L ++ EL +A++ A +R L +F + Sbjct: 2213 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2272 Query: 519 ARELQGQIEEKRRRL-------PRLTTPPE-----PRPSASSM-QRTLRAFEHDLQLLV- 564 E Q+ E+ RL RL E R A M + ++A + +L Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2332 Query: 565 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622 +++ Q Q+ AQ + E E +A + E QG++ L A +L +S+ A+ L+ Sbjct: 2333 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390 Score = 58.9 bits (141), Expect = 1e-08 Identities = 130/625 (20%), Positives = 238/625 (38%), Gaps = 123/625 (19%) Query: 18 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 76 +W+RH E + E+IE Q ++ K EL A K + + LE Q Sbjct: 297 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 355 Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136 A ++ + + + +L +L E QL+ S+ ++L+ ++ V Sbjct: 356 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 403 Query: 137 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + E G + E+L + LQ RLL A K + Q Sbjct: 404 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 438 Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 254 A +++ +L + L N +Q ++ +H + Q RR + H ER Sbjct: 439 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 484 Query: 255 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313 L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+ Sbjct: 485 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 536 Query: 314 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373 E + + + G D S L H L Q +E + RA +E D Q Sbjct: 537 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 585 Query: 374 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425 +S ++D Y L + R +LE L+ ++ W+ EKE Sbjct: 586 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 640 Query: 426 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481 E+G D+ +++ +E +S E + +++ + D L+ H A T+ Sbjct: 641 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 697 Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541 ++ L W+ +L+L L + +FFSD RE +GQ+++ + L Sbjct: 698 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 749 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 598 R + T+ E LQ + QL E Y G H +A R + V+Q Sbjct: 750 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 800 Query: 599 --------GWKELLSACEDARLHVS 615 G LL+ C+ ++ V+ Sbjct: 801 RHPAHPMRGRLPLLAVCDYKQVEVT 825 Score = 52.4 bits (124), Expect = 1e-06 Identities = 107/433 (24%), Positives = 179/433 (41%), Gaps = 65/433 (15%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 +LAQ + EK+ +E Q +QE L A E+ Q EL Q +AR+L E Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAE-----AELLQQQKEL---AQEQARRLQE--D 2353 Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147 +Q+ Q AE E+Q G T+ ++ ++ M ++ E V E+ + Sbjct: 2354 KEQMAQQLAE--------ETQ-------GFQRTLEAERQRQLEMSAEAERLKLRVAEM-S 2397 Query: 148 QTAALPLEPASK-----ELVGE---RQNAVGERLVRLLEPLQERR--------RLLLASK 191 + A E A + E +GE R + V L++ L+ +R RL A Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2457 Query: 192 ELHQVAHDLDDELAWVQ---ERLPLAMQTERGNGLQAVQQHI--KKNQGLRRE--IQAHG 244 EL + L E +Q E + Q + QA+QQ +K+ L+RE I+ Sbjct: 2458 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2517 Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304 +LE++ + A A E + ++ +EQ + E A RRQ +A V + Sbjct: 2518 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH--EAEEGVRRKQE 2575 Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364 ++ ++E +QE L+ E++ EQ LQLL++ Q + + EE A + L Sbjct: 2576 ELQQLEQQRRQQEELLAEENQRLREQ--LQLLEE--QHRAALAHSEEVTASQVAATKTLP 2631 Query: 365 E----MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL----- 415 + P +E R V+ + L E ++ E+ L Q V EL Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2691 Query: 416 -EHWIAEKEVVAG 427 H++ + +AG Sbjct: 2692 VRHYLQGRSSIAG 2704 Score = 35.8 bits (81), Expect = 0.13 Identities = 69/272 (25%), Positives = 113/272 (41%), Gaps = 53/272 (19%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82 Q F E+A+ ++ E+ +R+ QQ+ QE+ L AS+ E R+ E E + K +L Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME----EARRRQHEAEEGVRRKQEEL 2577 Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142 QL Q + ++ L +L++ +LQ +E Q Sbjct: 2578 ------QQLEQQRRQQEELLAEENQRLRE---------------QLQLLEEQHRAALAHS 2616 Query: 143 GELQA-QTAALPLEPASKE-LVGERQNAVGERLVRLLEPLQERRRL----LLASKELHQV 196 E+ A Q AA P ++ L G A E L +RL +L+++EL ++ Sbjct: 2617 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2676 Query: 197 A--HDLDDELA-------WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 247 A H DELA ++Q R +A G L+A + + L+R++ + G L Sbjct: 2677 AQGHTTVDELARREDVRHYLQGRSSIA-----GLLLKATNEKLSVYAALQRQLLSPGTAL 2731 Query: 248 EEVLERAGALASLRSPEA-------EAVRRGL 272 +LE A L P EAV+ G+ Sbjct: 2732 -ILLEAQAASGFLLDPVRNRRLTVNEAVKEGV 2762 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 70.5 bits (171), Expect = 5e-12 Identities = 140/625 (22%), Positives = 248/625 (39%), Gaps = 59/625 (9%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 EL + E+ E + +Q +E L V+ + RQ EL S +A+A E + Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533 Query: 88 ADQLVQSFA----ELDKKLLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQV 135 A Q ++ E +++L E + L+ + A + S+ +Q+ Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQL 1592 Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELH 194 E +E AQ A ++ ER ER L R E RL L ++E+ Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652 Query: 195 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 254 Q E +E + QAV+Q Q L ++ Q ++ L Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712 Query: 255 GALASLRSP--EAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 312 L LR+ + E R+ LE+ + AA +++Q L+A ++A+V A Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---------ELAKVRA- 1762 Query: 313 LGEQELLMMSEDKGKDE-QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD- 370 E E+L+ S+ + ++E +ST + K+ L+ E G + E +A+ + + RAL E Sbjct: 1763 --EMEVLLASKARAEEESRSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQR 1817 Query: 371 ---SEQISRRQSQVDRLYVA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426 E +R++++ +R+ L +GE R+ E + L + + L +AE E Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQ 1876 Query: 427 GSPELGQDFEHVSVLQEKF--------SEFASETGMAGRERLAAVNQMVDELIECGHT-- 476 Q +H + ++E+ SE + G+ + L Q+ +E++ + Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFE 1935 Query: 477 -AAATMAEWKDGLNEAWA---------ELLELMGTRAQLLAASRELHKFFSDARELQGQI 526 AAA AE + L + E EL R + LAA E + ++ R + Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995 Query: 527 EEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586 E+ R E + ++ R E Q Q++ QE A + HA Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055 Query: 587 EAIASREQEVLQGWKELLSACEDAR 611 A+ +EQE+ Q ++ S + R Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLR 2080 Score = 64.7 bits (156), Expect = 3e-10 Identities = 131/640 (20%), Positives = 245/640 (38%), Gaps = 106/640 (16%) Query: 37 EKIEREGQQLMQEK---PELAASVRKK-LGEIRQCWAELESTTQAKARQLFEASKADQLV 92 E+ RE ++ +Q+ E AA RK L E+ + A++E + + R E+++ QL Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039 Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152 Q A+ +LQ + A + + Q+++ + + GE +A A Sbjct: 2040 QEAAQ---------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090 Query: 153 PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 212 E + ER+ A R V E L++ ++ Q A E+L Sbjct: 2091 E-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----------AEKLR 2139 Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS------LRSPEAE 266 + E QA Q +++ Q E++ H E+ L + + L+ E + Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199 Query: 267 AVRRGL-EQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 + L E+LQ A EAA +R QV + F V ++++++A + + ++ DK Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259 Query: 326 GKDEQSTLQLLKKHLQLEQGVENY--------------EESIAQ---------------- 355 ++ + +K Q+ + EE +AQ Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2319 Query: 356 -----LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE--LGEERRVALEQQYWLYQL 408 L + L + EQ R Q +++ L E G +R + E+Q L ++ Sbjct: 2320 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EM 2378 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468 S + L+ +AE E +D + E+ E T +A +E++ V + Sbjct: 2379 SAEAERLKLRVAEMSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436 Query: 469 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 528 + + H A + L EA AEL RE K +A+ LQ + EE Sbjct: 2437 QRQQSDHDA--------ERLREAIAEL-------------EREKEKLQQEAKLLQLKSEE 2475 Query: 529 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 588 + + Q ++F + L+ + R +++ A+L ++ E A+A Sbjct: 2476 MQ--------TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527 Query: 589 IASRE------QEVLQGWKELLSACEDARLHVSSTADALR 622 RE Q++ Q + L+++ E+AR + +R Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567 Score = 63.9 bits (154), Expect = 5e-10 Identities = 134/617 (21%), Positives = 247/617 (40%), Gaps = 51/617 (8%) Query: 9 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 68 +E + +R Q AE+ + + ++ E ++++ PE + + E+ Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTL 1071 Query: 69 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 128 +LE A L + +++ ++ L E QL++ V + L +L Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ------AVPATLPEL 1125 Query: 129 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGER-QNAVGERLVRL------LEPLQ 181 ++ ++ +++ + Q AL E + VGER Q GER V + + L Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185 Query: 182 ERRRLLLAS-----KELHQVAHDL-------DDELAWVQE--RLPLAMQTERGNGLQAVQ 227 ER + +LA +EL Q+ L D AW+Q+ R +Q QAV+ Sbjct: 1186 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1245 Query: 228 QHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLRE 284 + +++ Q L EI+ HG ++EE A + +++ E + V + LE + S A + Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPK 1304 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341 + V+ + +Y ++ + + + L M E++ EQ + ++ + Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401 +E +E + +A+ Q +A E + +Q R Q +V R A + +++R E+ Sbjct: 1365 VEAALEK-QRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE 1421 Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLA 461 L QL RQ SE E ++ A + E + V++ + + G A E L Sbjct: 1422 ---LQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQ 1476 Query: 462 AVNQMVDEL----IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517 A+ +E + A + +D +EL A+RE + Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536 Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577 EL+ Q EE RRL R R +++ R+ E +LQ S+ E AQL Sbjct: 1537 ALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAELQ---SKRASFAEKTAQL 1592 Query: 578 RTVYAGEHAEAIASREQ 594 EH RE+ Sbjct: 1593 ERSLQEEHVAVAQLREE 1609 Score = 61.6 bits (148), Expect = 2e-09 Identities = 160/718 (22%), Positives = 285/718 (39%), Gaps = 134/718 (18%) Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLE----KIEREGQQLMQEKPELAASVRKKL 61 +GT + + +R +A + Q ++ LE +++RE Q++ EL A Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA------ 1755 Query: 62 GEIRQCWAELESTTQAKARQLFE----ASKADQLVQS----FAELDKKLLHMESQLQDVD 113 E+ + AE+E +KAR E + K+ Q +++ F EL ++ + + ++ Sbjct: 1756 -ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814 Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERL 173 LA ++ ++ ++ E + E +GE A E A KE + A ERL Sbjct: 1815 RQRQLAEEDAARQRAEA-ERVLAEKLAAIGE--ATRLKTEAEIALKE-----KEAENERL 1866 Query: 174 VRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKN 233 RL E +RR L H+ D+++ LA Q R + ER GL V+ +++ Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKA--DIEERLA--QLRKASDSELERQKGL--VEDTLRQR 1920 Query: 234 QGLRREI--------QAHGPRLEEVLE----RAGALASLRSPE-------------AEAV 268 + + EI +A + E LE R+ A +LRS E AE Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980 Query: 269 RR---GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 RR E++Q + A EAA +R+ L+ +VE+ V E E ++ Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALE---EVERLKAKVEEARRLRERAE-----QES 2032 Query: 326 GKDEQSTLQLLKKHLQLEQ-----GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380 + Q + +K LQ E+ V+ E+ + Q +Q +++L+ ++E R + Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092 Query: 381 VDRLYV-----------------ALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423 + V LK+ EE+ A Q + R+ +E E A + Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---AARR 2149 Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH-------- 475 A L Q + EK +FA +T + + + +L E H Sbjct: 2150 AQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208 Query: 476 ---------TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL--------HKFFSD 518 AA ++ ++ L ++ EL +A++ A +R L +F + Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268 Query: 519 ARELQGQIEEKRRRL-------PRLTTPPE-----PRPSASSM-QRTLRAFEHDLQLLV- 564 E Q+ E+ RL RL E R A M + ++A + +L Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2328 Query: 565 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622 +++ Q Q+ AQ + E E +A + E QG++ L A +L +S+ A+ L+ Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386 Score = 58.9 bits (141), Expect = 1e-08 Identities = 130/625 (20%), Positives = 238/625 (38%), Gaps = 123/625 (19%) Query: 18 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 76 +W+RH E + E+IE Q ++ K EL A K + + LE Q Sbjct: 293 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 351 Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136 A ++ + + + +L +L E QL+ S+ ++L+ ++ V Sbjct: 352 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 399 Query: 137 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + E G + E+L + LQ RLL A K + Q Sbjct: 400 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 434 Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 254 A +++ +L + L N +Q ++ +H + Q RR + H ER Sbjct: 435 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 480 Query: 255 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313 L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+ Sbjct: 481 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 532 Query: 314 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373 E + + + G D S L H L Q +E + RA +E D Q Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 581 Query: 374 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425 +S ++D Y L + R +LE L+ ++ W+ EKE Sbjct: 582 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 636 Query: 426 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481 E+G D+ +++ +E +S E + +++ + D L+ H A T+ Sbjct: 637 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 693 Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541 ++ L W+ +L+L L + +FFSD RE +GQ+++ + L Sbjct: 694 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 745 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 598 R + T+ E LQ + QL E Y G H +A R + V+Q Sbjct: 746 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 796 Query: 599 --------GWKELLSACEDARLHVS 615 G LL+ C+ ++ V+ Sbjct: 797 RHPAHPMRGRLPLLAVCDYKQVEVT 821 Score = 52.4 bits (124), Expect = 1e-06 Identities = 107/433 (24%), Positives = 179/433 (41%), Gaps = 65/433 (15%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 +LAQ + EK+ +E Q +QE L A E+ Q EL Q +AR+L E Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAE-----AELLQQQKEL---AQEQARRLQE--D 2349 Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147 +Q+ Q AE E+Q G T+ ++ ++ M ++ E V E+ + Sbjct: 2350 KEQMAQQLAE--------ETQ-------GFQRTLEAERQRQLEMSAEAERLKLRVAEM-S 2393 Query: 148 QTAALPLEPASK-----ELVGE---RQNAVGERLVRLLEPLQERR--------RLLLASK 191 + A E A + E +GE R + V L++ L+ +R RL A Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453 Query: 192 ELHQVAHDLDDELAWVQ---ERLPLAMQTERGNGLQAVQQHI--KKNQGLRRE--IQAHG 244 EL + L E +Q E + Q + QA+QQ +K+ L+RE I+ Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513 Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304 +LE++ + A A E + ++ +EQ + E A RRQ +A V + Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH--EAEEGVRRKQE 2571 Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364 ++ ++E +QE L+ E++ EQ LQLL++ Q + + EE A + L Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQ--LQLLEE--QHRAALAHSEEVTASQVAATKTLP 2627 Query: 365 E----MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL----- 415 + P +E R V+ + L E ++ E+ L Q V EL Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2687 Query: 416 -EHWIAEKEVVAG 427 H++ + +AG Sbjct: 2688 VRHYLQGRSSIAG 2700 Score = 35.8 bits (81), Expect = 0.13 Identities = 69/272 (25%), Positives = 113/272 (41%), Gaps = 53/272 (19%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82 Q F E+A+ ++ E+ +R+ QQ+ QE+ L AS+ E R+ E E + K +L Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME----EARRRQHEAEEGVRRKQEEL 2573 Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142 QL Q + ++ L +L++ +LQ +E Q Sbjct: 2574 ------QQLEQQRRQQEELLAEENQRLRE---------------QLQLLEEQHRAALAHS 2612 Query: 143 GELQA-QTAALPLEPASKE-LVGERQNAVGERLVRLLEPLQERRRL----LLASKELHQV 196 E+ A Q AA P ++ L G A E L +RL +L+++EL ++ Sbjct: 2613 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2672 Query: 197 A--HDLDDELA-------WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 247 A H DELA ++Q R +A G L+A + + L+R++ + G L Sbjct: 2673 AQGHTTVDELARREDVRHYLQGRSSIA-----GLLLKATNEKLSVYAALQRQLLSPGTAL 2727 Query: 248 EEVLERAGALASLRSPEA-------EAVRRGL 272 +LE A L P EAV+ G+ Sbjct: 2728 -ILLEAQAASGFLLDPVRNRRLTVNEAVKEGV 2758 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 70.5 bits (171), Expect = 5e-12 Identities = 140/625 (22%), Positives = 248/625 (39%), Gaps = 59/625 (9%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 EL + E+ E + +Q +E L V+ + RQ EL S +A+A E + Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1501 Query: 88 ADQLVQSFA----ELDKKLLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQV 135 A Q ++ E +++L E + L+ + A + S+ +Q+ Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQL 1560 Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELH 194 E +E AQ A ++ ER ER L R E RL L ++E+ Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1620 Query: 195 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 254 Q E +E + QAV+Q Q L ++ Q ++ L Sbjct: 1621 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1680 Query: 255 GALASLRSP--EAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 312 L LR+ + E R+ LE+ + AA +++Q L+A ++A+V A Sbjct: 1681 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---------ELAKVRA- 1730 Query: 313 LGEQELLMMSEDKGKDE-QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD- 370 E E+L+ S+ + ++E +ST + K+ L+ E G + E +A+ + + RAL E Sbjct: 1731 --EMEVLLASKARAEEESRSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQR 1785 Query: 371 ---SEQISRRQSQVDRLYVA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426 E +R++++ +R+ L +GE R+ E + L + + L +AE E Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQ 1844 Query: 427 GSPELGQDFEHVSVLQEKF--------SEFASETGMAGRERLAAVNQMVDELIECGHT-- 476 Q +H + ++E+ SE + G+ + L Q+ +E++ + Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFE 1903 Query: 477 -AAATMAEWKDGLNEAWA---------ELLELMGTRAQLLAASRELHKFFSDARELQGQI 526 AAA AE + L + E EL R + LAA E + ++ R + Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963 Query: 527 EEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586 E+ R E + ++ R E Q Q++ QE A + HA Sbjct: 1964 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2023 Query: 587 EAIASREQEVLQGWKELLSACEDAR 611 A+ +EQE+ Q ++ S + R Sbjct: 2024 FAVQQKEQELQQTLQQEQSVLDQLR 2048 Score = 64.7 bits (156), Expect = 3e-10 Identities = 131/640 (20%), Positives = 245/640 (38%), Gaps = 106/640 (16%) Query: 37 EKIEREGQQLMQEK---PELAASVRKK-LGEIRQCWAELESTTQAKARQLFEASKADQLV 92 E+ RE ++ +Q+ E AA RK L E+ + A++E + + R E+++ QL Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007 Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152 Q A+ +LQ + A + + Q+++ + + GE +A A Sbjct: 2008 QEAAQ---------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058 Query: 153 PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 212 E + ER+ A R V E L++ ++ Q A E+L Sbjct: 2059 E-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----------AEKLR 2107 Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS------LRSPEAE 266 + E QA Q +++ Q E++ H E+ L + + L+ E + Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167 Query: 267 AVRRGL-EQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 + L E+LQ A EAA +R QV + F V ++++++A + + ++ DK Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2227 Query: 326 GKDEQSTLQLLKKHLQLEQGVENY--------------EESIAQ---------------- 355 ++ + +K Q+ + EE +AQ Sbjct: 2228 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2287 Query: 356 -----LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE--LGEERRVALEQQYWLYQL 408 L + L + EQ R Q +++ L E G +R + E+Q L ++ Sbjct: 2288 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EM 2346 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468 S + L+ +AE E +D + E+ E T +A +E++ V + Sbjct: 2347 SAEAERLKLRVAEMSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404 Query: 469 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 528 + + H A + L EA AEL RE K +A+ LQ + EE Sbjct: 2405 QRQQSDHDA--------ERLREAIAEL-------------EREKEKLQQEAKLLQLKSEE 2443 Query: 529 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 588 + + Q ++F + L+ + R +++ A+L ++ E A+A Sbjct: 2444 MQ--------TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495 Query: 589 IASRE------QEVLQGWKELLSACEDARLHVSSTADALR 622 RE Q++ Q + L+++ E+AR + +R Sbjct: 2496 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535 Score = 63.9 bits (154), Expect = 5e-10 Identities = 134/617 (21%), Positives = 247/617 (40%), Gaps = 51/617 (8%) Query: 9 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 68 +E + +R Q AE+ + + ++ E ++++ PE + + E+ Sbjct: 981 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTL 1039 Query: 69 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 128 +LE A L + +++ ++ L E QL++ V + L +L Sbjct: 1040 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ------AVPATLPEL 1093 Query: 129 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGER-QNAVGERLVRL------LEPLQ 181 ++ ++ +++ + Q AL E + VGER Q GER V + + L Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1153 Query: 182 ERRRLLLAS-----KELHQVAHDL-------DDELAWVQE--RLPLAMQTERGNGLQAVQ 227 ER + +LA +EL Q+ L D AW+Q+ R +Q QAV+ Sbjct: 1154 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1213 Query: 228 QHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLRE 284 + +++ Q L EI+ HG ++EE A + +++ E + V + LE + S A + Sbjct: 1214 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPK 1272 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341 + V+ + +Y ++ + + + L M E++ EQ + ++ + Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1332 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401 +E +E + +A+ Q +A E + +Q R Q +V R A + +++R E+ Sbjct: 1333 VEAALEK-QRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE 1389 Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLA 461 L QL RQ SE E ++ A + E + V++ + + G A E L Sbjct: 1390 ---LQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQ 1444 Query: 462 AVNQMVDEL----IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517 A+ +E + A + +D +EL A+RE + Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504 Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577 EL+ Q EE RRL R R +++ R+ E +LQ S+ E AQL Sbjct: 1505 ALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAELQ---SKRASFAEKTAQL 1560 Query: 578 RTVYAGEHAEAIASREQ 594 EH RE+ Sbjct: 1561 ERSLQEEHVAVAQLREE 1577 Score = 61.6 bits (148), Expect = 2e-09 Identities = 160/718 (22%), Positives = 285/718 (39%), Gaps = 134/718 (18%) Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLE----KIEREGQQLMQEKPELAASVRKKL 61 +GT + + +R +A + Q ++ LE +++RE Q++ EL A Sbjct: 1670 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA------ 1723 Query: 62 GEIRQCWAELESTTQAKARQLFE----ASKADQLVQS----FAELDKKLLHMESQLQDVD 113 E+ + AE+E +KAR E + K+ Q +++ F EL ++ + + ++ Sbjct: 1724 -ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782 Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERL 173 LA ++ ++ ++ E + E +GE A E A KE + A ERL Sbjct: 1783 RQRQLAEEDAARQRAEA-ERVLAEKLAAIGE--ATRLKTEAEIALKE-----KEAENERL 1834 Query: 174 VRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKN 233 RL E +RR L H+ D+++ LA Q R + ER GL V+ +++ Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKA--DIEERLA--QLRKASDSELERQKGL--VEDTLRQR 1888 Query: 234 QGLRREI--------QAHGPRLEEVLE----RAGALASLRSPE-------------AEAV 268 + + EI +A + E LE R+ A +LRS E AE Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948 Query: 269 RR---GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 RR E++Q + A EAA +R+ L+ +VE+ V E E ++ Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALE---EVERLKAKVEEARRLRERAE-----QES 2000 Query: 326 GKDEQSTLQLLKKHLQLEQ-----GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380 + Q + +K LQ E+ V+ E+ + Q +Q +++L+ ++E R + Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060 Query: 381 VDRLYV-----------------ALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423 + V LK+ EE+ A Q + R+ +E E A + Sbjct: 2061 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---AARR 2117 Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH-------- 475 A L Q + EK +FA +T + + + +L E H Sbjct: 2118 AQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176 Query: 476 ---------TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL--------HKFFSD 518 AA ++ ++ L ++ EL +A++ A +R L +F + Sbjct: 2177 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2236 Query: 519 ARELQGQIEEKRRRL-------PRLTTPPE-----PRPSASSM-QRTLRAFEHDLQLLV- 564 E Q+ E+ RL RL E R A M + ++A + +L Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2296 Query: 565 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622 +++ Q Q+ AQ + E E +A + E QG++ L A +L +S+ A+ L+ Sbjct: 2297 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354 Score = 58.9 bits (141), Expect = 1e-08 Identities = 130/625 (20%), Positives = 238/625 (38%), Gaps = 123/625 (19%) Query: 18 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 76 +W+RH E + E+IE Q ++ K EL A K + + LE Q Sbjct: 261 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 319 Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136 A ++ + + + +L +L E QL+ S+ ++L+ ++ V Sbjct: 320 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 367 Query: 137 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + E G + E+L + LQ RLL A K + Q Sbjct: 368 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 402 Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 254 A +++ +L + L N +Q ++ +H + Q RR + H ER Sbjct: 403 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 448 Query: 255 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313 L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+ Sbjct: 449 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 500 Query: 314 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373 E + + + G D S L H L Q +E + RA +E D Q Sbjct: 501 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 549 Query: 374 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425 +S ++D Y L + R +LE L+ ++ W+ EKE Sbjct: 550 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 604 Query: 426 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481 E+G D+ +++ +E +S E + +++ + D L+ H A T+ Sbjct: 605 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 661 Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541 ++ L W+ +L+L L + +FFSD RE +GQ+++ + L Sbjct: 662 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 713 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 598 R + T+ E LQ + QL E Y G H +A R + V+Q Sbjct: 714 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 764 Query: 599 --------GWKELLSACEDARLHVS 615 G LL+ C+ ++ V+ Sbjct: 765 RHPAHPMRGRLPLLAVCDYKQVEVT 789 Score = 52.4 bits (124), Expect = 1e-06 Identities = 107/433 (24%), Positives = 179/433 (41%), Gaps = 65/433 (15%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 +LAQ + EK+ +E Q +QE L A E+ Q EL Q +AR+L E Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAE-----AELLQQQKEL---AQEQARRLQE--D 2317 Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147 +Q+ Q AE E+Q G T+ ++ ++ M ++ E V E+ + Sbjct: 2318 KEQMAQQLAE--------ETQ-------GFQRTLEAERQRQLEMSAEAERLKLRVAEM-S 2361 Query: 148 QTAALPLEPASK-----ELVGE---RQNAVGERLVRLLEPLQERR--------RLLLASK 191 + A E A + E +GE R + V L++ L+ +R RL A Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2421 Query: 192 ELHQVAHDLDDELAWVQ---ERLPLAMQTERGNGLQAVQQHI--KKNQGLRRE--IQAHG 244 EL + L E +Q E + Q + QA+QQ +K+ L+RE I+ Sbjct: 2422 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2481 Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304 +LE++ + A A E + ++ +EQ + E A RRQ +A V + Sbjct: 2482 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH--EAEEGVRRKQE 2539 Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364 ++ ++E +QE L+ E++ EQ LQLL++ Q + + EE A + L Sbjct: 2540 ELQQLEQQRRQQEELLAEENQRLREQ--LQLLEE--QHRAALAHSEEVTASQVAATKTLP 2595 Query: 365 E----MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL----- 415 + P +E R V+ + L E ++ E+ L Q V EL Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2655 Query: 416 -EHWIAEKEVVAG 427 H++ + +AG Sbjct: 2656 VRHYLQGRSSIAG 2668 Score = 35.8 bits (81), Expect = 0.13 Identities = 69/272 (25%), Positives = 113/272 (41%), Gaps = 53/272 (19%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82 Q F E+A+ ++ E+ +R+ QQ+ QE+ L AS+ E R+ E E + K +L Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME----EARRRQHEAEEGVRRKQEEL 2541 Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142 QL Q + ++ L +L++ +LQ +E Q Sbjct: 2542 ------QQLEQQRRQQEELLAEENQRLRE---------------QLQLLEEQHRAALAHS 2580 Query: 143 GELQA-QTAALPLEPASKE-LVGERQNAVGERLVRLLEPLQERRRL----LLASKELHQV 196 E+ A Q AA P ++ L G A E L +RL +L+++EL ++ Sbjct: 2581 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2640 Query: 197 A--HDLDDELA-------WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 247 A H DELA ++Q R +A G L+A + + L+R++ + G L Sbjct: 2641 AQGHTTVDELARREDVRHYLQGRSSIA-----GLLLKATNEKLSVYAALQRQLLSPGTAL 2695 Query: 248 EEVLERAGALASLRSPEA-------EAVRRGL 272 +LE A L P EAV+ G+ Sbjct: 2696 -ILLEAQAASGFLLDPVRNRRLTVNEAVKEGV 2726 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 70.5 bits (171), Expect = 5e-12 Identities = 140/625 (22%), Positives = 248/625 (39%), Gaps = 59/625 (9%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 EL + E+ E + +Q +E L V+ + RQ EL S +A+A E + Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1670 Query: 88 ADQLVQSFA----ELDKKLLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQV 135 A Q ++ E +++L E + L+ + A + S+ +Q+ Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQL 1729 Query: 136 EEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELH 194 E +E AQ A ++ ER ER L R E RL L ++E+ Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1789 Query: 195 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 254 Q E +E + QAV+Q Q L ++ Q ++ L Sbjct: 1790 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1849 Query: 255 GALASLRSP--EAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 312 L LR+ + E R+ LE+ + AA +++Q L+A ++A+V A Sbjct: 1850 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---------ELAKVRA- 1899 Query: 313 LGEQELLMMSEDKGKDE-QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD- 370 E E+L+ S+ + ++E +ST + K+ L+ E G + E +A+ + + RAL E Sbjct: 1900 --EMEVLLASKARAEEESRSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQR 1954 Query: 371 ---SEQISRRQSQVDRLYVA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426 E +R++++ +R+ L +GE R+ E + L + + L +AE E Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQ 2013 Query: 427 GSPELGQDFEHVSVLQEKF--------SEFASETGMAGRERLAAVNQMVDELIECGHT-- 476 Q +H + ++E+ SE + G+ + L Q+ +E++ + Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFE 2072 Query: 477 -AAATMAEWKDGLNEAWA---------ELLELMGTRAQLLAASRELHKFFSDARELQGQI 526 AAA AE + L + E EL R + LAA E + ++ R + Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132 Query: 527 EEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586 E+ R E + ++ R E Q Q++ QE A + HA Sbjct: 2133 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2192 Query: 587 EAIASREQEVLQGWKELLSACEDAR 611 A+ +EQE+ Q ++ S + R Sbjct: 2193 FAVQQKEQELQQTLQQEQSVLDQLR 2217 Score = 64.7 bits (156), Expect = 3e-10 Identities = 131/640 (20%), Positives = 245/640 (38%), Gaps = 106/640 (16%) Query: 37 EKIEREGQQLMQEK---PELAASVRKK-LGEIRQCWAELESTTQAKARQLFEASKADQLV 92 E+ RE ++ +Q+ E AA RK L E+ + A++E + + R E+++ QL Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176 Query: 93 QSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL 152 Q A+ +LQ + A + + Q+++ + + GE +A A Sbjct: 2177 QEAAQ---------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227 Query: 153 PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 212 E + ER+ A R V E L++ ++ Q A E+L Sbjct: 2228 E-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----------AEKLR 2276 Query: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS------LRSPEAE 266 + E QA Q +++ Q E++ H E+ L + + L+ E + Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336 Query: 267 AVRRGL-EQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 + L E+LQ A EAA +R QV + F V ++++++A + + ++ DK Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2396 Query: 326 GKDEQSTLQLLKKHLQLEQGVENY--------------EESIAQ---------------- 355 ++ + +K Q+ + EE +AQ Sbjct: 2397 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2456 Query: 356 -----LSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE--LGEERRVALEQQYWLYQL 408 L + L + EQ R Q +++ L E G +R + E+Q L ++ Sbjct: 2457 QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EM 2515 Query: 409 SRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 468 S + L+ +AE E +D + E+ E T +A +E++ V + Sbjct: 2516 SAEAERLKLRVAEMSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573 Query: 469 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 528 + + H A + L EA AEL RE K +A+ LQ + EE Sbjct: 2574 QRQQSDHDA--------ERLREAIAEL-------------EREKEKLQQEAKLLQLKSEE 2612 Query: 529 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 588 + + Q ++F + L+ + R +++ A+L ++ E A+A Sbjct: 2613 MQ--------TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664 Query: 589 IASRE------QEVLQGWKELLSACEDARLHVSSTADALR 622 RE Q++ Q + L+++ E+AR + +R Sbjct: 2665 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704 Score = 63.9 bits (154), Expect = 5e-10 Identities = 134/617 (21%), Positives = 247/617 (40%), Gaps = 51/617 (8%) Query: 9 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 68 +E + +R Q AE+ + + ++ E ++++ PE + + E+ Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTL 1208 Query: 69 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 128 +LE A L + +++ ++ L E QL++ V + L +L Sbjct: 1209 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ------AVPATLPEL 1262 Query: 129 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGER-QNAVGERLVRL------LEPLQ 181 ++ ++ +++ + Q AL E + VGER Q GER V + + L Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322 Query: 182 ERRRLLLAS-----KELHQVAHDL-------DDELAWVQE--RLPLAMQTERGNGLQAVQ 227 ER + +LA +EL Q+ L D AW+Q+ R +Q QAV+ Sbjct: 1323 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1382 Query: 228 QHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLRE 284 + +++ Q L EI+ HG ++EE A + +++ E + V + LE + S A + Sbjct: 1383 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPK 1441 Query: 285 AAERRQQVLDAAFQVEQYYFDVAEVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQ 341 + V+ + +Y ++ + + + L M E++ EQ + ++ + Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1501 Query: 342 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 401 +E +E + +A+ Q +A E + +Q R Q +V R A + +++R E+ Sbjct: 1502 VEAALEK-QRQLAEAHAQAKAQAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE 1558 Query: 402 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLA 461 L QL RQ SE E ++ A + E + V++ + + G A E L Sbjct: 1559 ---LQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQ 1613 Query: 462 AVNQMVDEL----IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 517 A+ +E + A + +D +EL A+RE + Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673 Query: 518 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 577 EL+ Q EE RRL R R +++ R+ E +LQ S+ E AQL Sbjct: 1674 ALEELRLQAEEAERRL-RQAEVERARQVQVALETAQRSAEAELQ---SKRASFAEKTAQL 1729 Query: 578 RTVYAGEHAEAIASREQ 594 EH RE+ Sbjct: 1730 ERSLQEEHVAVAQLREE 1746 Score = 61.6 bits (148), Expect = 2e-09 Identities = 160/718 (22%), Positives = 285/718 (39%), Gaps = 134/718 (18%) Query: 6 DGTREDNHKLHKRWLRHQAFMAELAQNKEWLE----KIEREGQQLMQEKPELAASVRKKL 61 +GT + + +R +A + Q ++ LE +++RE Q++ EL A Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA------ 1892 Query: 62 GEIRQCWAELESTTQAKARQLFE----ASKADQLVQS----FAELDKKLLHMESQLQDVD 113 E+ + AE+E +KAR E + K+ Q +++ F EL ++ + + ++ Sbjct: 1893 -ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951 Query: 114 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERL 173 LA ++ ++ ++ E + E +GE A E A KE + A ERL Sbjct: 1952 RQRQLAEEDAARQRAEA-ERVLAEKLAAIGE--ATRLKTEAEIALKE-----KEAENERL 2003 Query: 174 VRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKN 233 RL E +RR L H+ D+++ LA Q R + ER GL V+ +++ Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKA--DIEERLA--QLRKASDSELERQKGL--VEDTLRQR 2057 Query: 234 QGLRREI--------QAHGPRLEEVLE----RAGALASLRSPE-------------AEAV 268 + + EI +A + E LE R+ A +LRS E AE Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117 Query: 269 RR---GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 325 RR E++Q + A EAA +R+ L+ +VE+ V E E ++ Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALE---EVERLKAKVEEARRLRERAE-----QES 2169 Query: 326 GKDEQSTLQLLKKHLQLEQ-----GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQ 380 + Q + +K LQ E+ V+ E+ + Q +Q +++L+ ++E R + Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229 Query: 381 VDRLYV-----------------ALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 423 + V LK+ EE+ A Q + R+ +E E A + Sbjct: 2230 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---AARR 2286 Query: 424 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGH-------- 475 A L Q + EK +FA +T + + + +L E H Sbjct: 2287 AQAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345 Query: 476 ---------TAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL--------HKFFSD 518 AA ++ ++ L ++ EL +A++ A +R L +F + Sbjct: 2346 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2405 Query: 519 ARELQGQIEEKRRRL-------PRLTTPPE-----PRPSASSM-QRTLRAFEHDLQLLV- 564 E Q+ E+ RL RL E R A M + ++A + +L Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2465 Query: 565 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR 622 +++ Q Q+ AQ + E E +A + E QG++ L A +L +S+ A+ L+ Sbjct: 2466 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523 Score = 58.9 bits (141), Expect = 1e-08 Identities = 130/625 (20%), Positives = 238/625 (38%), Gaps = 123/625 (19%) Query: 18 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 76 +W+RH E + E+IE Q ++ K EL A K + + LE Q Sbjct: 430 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 488 Query: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136 A ++ + + + +L +L E QL+ S+ ++L+ ++ V Sbjct: 489 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 536 Query: 137 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196 + E G + E+L + LQ RLL A K + Q Sbjct: 537 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 571 Query: 197 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 254 A +++ +L + L N +Q ++ +H + Q RR + H ER Sbjct: 572 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 617 Query: 255 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 313 L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+ Sbjct: 618 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 669 Query: 314 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 373 E + + + G D S L H L Q +E + RA +E D Q Sbjct: 670 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 718 Query: 374 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 425 +S ++D Y L + R +LE L+ ++ W+ EKE Sbjct: 719 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 773 Query: 426 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 481 E+G D+ +++ +E +S E + +++ + D L+ H A T+ Sbjct: 774 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 830 Query: 482 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 541 ++ L W+ +L+L L + +FFSD RE +GQ+++ + L Sbjct: 831 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 882 Query: 542 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 598 R + T+ E LQ + QL E Y G H +A R + V+Q Sbjct: 883 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 933 Query: 599 --------GWKELLSACEDARLHVS 615 G LL+ C+ ++ V+ Sbjct: 934 RHPAHPMRGRLPLLAVCDYKQVEVT 958 Score = 52.4 bits (124), Expect = 1e-06 Identities = 107/433 (24%), Positives = 179/433 (41%), Gaps = 65/433 (15%) Query: 28 ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK 87 +LAQ + EK+ +E Q +QE L A E+ Q EL Q +AR+L E Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAE-----AELLQQQKEL---AQEQARRLQE--D 2486 Query: 88 ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQA 147 +Q+ Q AE E+Q G T+ ++ ++ M ++ E V E+ + Sbjct: 2487 KEQMAQQLAE--------ETQ-------GFQRTLEAERQRQLEMSAEAERLKLRVAEM-S 2530 Query: 148 QTAALPLEPASK-----ELVGE---RQNAVGERLVRLLEPLQERR--------RLLLASK 191 + A E A + E +GE R + V L++ L+ +R RL A Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2590 Query: 192 ELHQVAHDLDDELAWVQ---ERLPLAMQTERGNGLQAVQQHI--KKNQGLRRE--IQAHG 244 EL + L E +Q E + Q + QA+QQ +K+ L+RE I+ Sbjct: 2591 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2650 Query: 245 PRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 304 +LE++ + A A E + ++ +EQ + E A RRQ +A V + Sbjct: 2651 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH--EAEEGVRRKQE 2708 Query: 305 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 364 ++ ++E +QE L+ E++ EQ LQLL++ Q + + EE A + L Sbjct: 2709 ELQQLEQQRRQQEELLAEENQRLREQ--LQLLEE--QHRAALAHSEEVTASQVAATKTLP 2764 Query: 365 E----MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSEL----- 415 + P +E R V+ + L E ++ E+ L Q V EL Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2824 Query: 416 -EHWIAEKEVVAG 427 H++ + +AG Sbjct: 2825 VRHYLQGRSSIAG 2837 Score = 35.8 bits (81), Expect = 0.13 Identities = 69/272 (25%), Positives = 113/272 (41%), Gaps = 53/272 (19%) Query: 23 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 82 Q F E+A+ ++ E+ +R+ QQ+ QE+ L AS+ E R+ E E + K +L Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME----EARRRQHEAEEGVRRKQEEL 2710 Query: 83 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 142 QL Q + ++ L +L++ +LQ +E Q Sbjct: 2711 ------QQLEQQRRQQEELLAEENQRLRE---------------QLQLLEEQHRAALAHS 2749 Query: 143 GELQA-QTAALPLEPASKE-LVGERQNAVGERLVRLLEPLQERRRL----LLASKELHQV 196 E+ A Q AA P ++ L G A E L +RL +L+++EL ++ Sbjct: 2750 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2809 Query: 197 A--HDLDDELA-------WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 247 A H DELA ++Q R +A G L+A + + L+R++ + G L Sbjct: 2810 AQGHTTVDELARREDVRHYLQGRSSIA-----GLLLKATNEKLSVYAALQRQLLSPGTAL 2864 Query: 248 EEVLERAGALASLRSPEA-------EAVRRGL 272 +LE A L P EAV+ G+ Sbjct: 2865 -ILLEAQAASGFLLDPVRNRRLTVNEAVKEGV 2895 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.128 0.364 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,630,196 Number of Sequences: 37866 Number of extensions: 1089547 Number of successful extensions: 8541 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 89 Number of HSP's successfully gapped in prelim test: 549 Number of HSP's that attempted gapping in prelim test: 5822 Number of HSP's gapped (non-prelim): 1995 length of query: 678 length of database: 18,247,518 effective HSP length: 109 effective length of query: 569 effective length of database: 14,120,124 effective search space: 8034350556 effective search space used: 8034350556 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.