Search of human proteins with 223718702

Search of human proteins with 223718702

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223718702 aflatoxin B1 aldehyde reductase 3 isoform 1 [Homo
sapiens]
         (331 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223718702 aflatoxin B1 aldehyde reductase 3 isoform 1 [Homo s...   682   0.0  
gi|41152114 aldo-keto reductase family 7, member A3 [Homo sapiens]    633   0.0  
gi|41327764 aldo-keto reductase family 7, member A2 [Homo sapiens]    613   e-176
gi|223718708 aflatoxin B1 aldehyde reductase 3 isoform 2 [Homo s...   344   7e-95
gi|4504825 potassium voltage-gated channel, shaker-related subfa...    86   5e-17
gi|27436969 potassium voltage-gated channel, shaker-related subf...    86   5e-17
gi|27436964 potassium voltage-gated channel, shaker-related subf...    84   2e-16
gi|27436962 potassium voltage-gated channel, shaker-related subf...    84   2e-16
gi|27436966 potassium voltage-gated channel, shaker-related subf...    84   2e-16
gi|27436971 potassium voltage-gated channel, shaker-related subf...    78   1e-14
gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens]      57   2e-08
gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens]     55   1e-07
gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens]     54   3e-07
gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens]      54   3e-07
gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens]     51   2e-06
gi|207028673 hypothetical protein LOC100134257 [Homo sapiens]          45   9e-05
gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]     37   0.032
gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]      37   0.032
gi|148529025 pleckstrin homology domain containing, family G (wi...    35   0.093
gi|71999153 hypothetical protein LOC23334 [Homo sapiens]               30   3.0  

>gi|223718702 aflatoxin B1 aldehyde reductase 3 isoform 1 [Homo
           sapiens]
          Length = 331

 Score =  682 bits (1759), Expect = 0.0
 Identities = 331/331 (100%), Positives = 331/331 (100%)

Query: 1   MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGG 60
           MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGG
Sbjct: 1   MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGG 60

Query: 61  LGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAP 120
           LGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCP VDLFYLHAPDHSAP
Sbjct: 61  LGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAP 120

Query: 121 VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVE 180
           VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVE
Sbjct: 121 VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVE 180

Query: 181 TELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYRNHFWKEH 240
           TELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYRNHFWKEH
Sbjct: 181 TELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYRNHFWKEH 240

Query: 241 HFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA 300
           HFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA
Sbjct: 241 HFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA 300

Query: 301 AAEEGPLEPAVVDAFNQAWHLFAHECPNYFI 331
           AAEEGPLEPAVVDAFNQAWHLFAHECPNYFI
Sbjct: 301 AAEEGPLEPAVVDAFNQAWHLFAHECPNYFI 331


>gi|41152114 aldo-keto reductase family 7, member A3 [Homo sapiens]
          Length = 331

 Score =  633 bits (1633), Expect = 0.0
 Identities = 305/330 (92%), Positives = 314/330 (95%)

Query: 1   MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGG 60
           MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAF+YS+GQSETILGG
Sbjct: 1   MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGG 60

Query: 61  LGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAP 120
           LGLR+G SDCRVKI TKA P  GNSLKPDS+R QLETSLKRLQCP VDLFYLH PDHS P
Sbjct: 61  LGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTP 120

Query: 121 VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVE 180
           VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMY+A TRQVE
Sbjct: 121 VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVE 180

Query: 181 TELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYRNHFWKEH 240
           TELFPCLRHFGLRFYA+NPLAGGLLTGKYKYEDK+GKQPVGRFFG  WAE+YRN +WKEH
Sbjct: 181 TELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEH 240

Query: 241 HFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA 300
           HFEGIALVEKALQAAYGASAPSMTSA LRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA
Sbjct: 241 HFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA 300

Query: 301 AAEEGPLEPAVVDAFNQAWHLFAHECPNYF 330
           AAEEGPLEPAVVDAFNQAWHL  HECPNYF
Sbjct: 301 AAEEGPLEPAVVDAFNQAWHLVTHECPNYF 330


>gi|41327764 aldo-keto reductase family 7, member A2 [Homo sapiens]
          Length = 359

 Score =  613 bits (1581), Expect = e-176
 Identities = 295/334 (88%), Positives = 306/334 (91%), Gaps = 5/334 (1%)

Query: 2   SRQLSRARP-----ATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSET 56
           +R L+ +RP     A+VLG MEMGRRMDAP SAA  RAFLERGHTE+DTAF+YSDGQSET
Sbjct: 25  ARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSET 84

Query: 57  ILGGLGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPD 116
           ILGGLGL +G  DCRVKIATKANPW G SLKPDSVRSQLETSLKRLQCP VDLFYLHAPD
Sbjct: 85  ILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPD 144

Query: 117 HSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATT 176
           H  PVEETL AC +LHQEGKFVELGLSNYA+WEVAEICTLCKSNGWILPTVYQGMY+ATT
Sbjct: 145 HGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATT 204

Query: 177 RQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYRNHF 236
           RQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFG  WAE YRN F
Sbjct: 205 RQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRF 264

Query: 237 WKEHHFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLE 296
           WKEHHFE IALVEKALQAAYGASAPS+TSAALRWMYHHSQLQGAHGDAVILGMSSLEQLE
Sbjct: 265 WKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLE 324

Query: 297 QNLAAAEEGPLEPAVVDAFNQAWHLFAHECPNYF 330
           QNLAA EEGPLEPAVVDAFNQAWHL AHECPNYF
Sbjct: 325 QNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYF 358


>gi|223718708 aflatoxin B1 aldehyde reductase 3 isoform 2 [Homo
           sapiens]
          Length = 249

 Score =  344 bits (882), Expect = 7e-95
 Identities = 171/177 (96%), Positives = 172/177 (97%)

Query: 1   MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGG 60
           MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGG
Sbjct: 1   MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGG 60

Query: 61  LGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAP 120
           LGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCP VDLFYLHAPDHSAP
Sbjct: 61  LGLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAP 120

Query: 121 VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTR 177
           VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQ +  A  R
Sbjct: 121 VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQLLEGAPLR 177


>gi|4504825 potassium voltage-gated channel, shaker-related
           subfamily, beta member 2 isoform 1 [Homo sapiens]
          Length = 367

 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 80/295 (27%), Positives = 134/295 (45%), Gaps = 23/295 (7%)

Query: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKAN 79
           G+  D      +T A+ + G    DTA +Y+ G++E +LG +  + G     + I TK  
Sbjct: 62  GQITDEMAEQLMTLAY-DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 120

Query: 80  PWIGNS-----LKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQE 134
            W G +     L    +   L+ SL+RLQ   VD+ + + PD + P+EET+RA   +  +
Sbjct: 121 -WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQ 179

Query: 135 GKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ-VETELFPCLRHFGLR 193
           G  +  G S +++ E+ E  ++ +      P   Q  Y    R+ VE +L       G+ 
Sbjct: 180 GMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVG 239

Query: 194 FYAYNPLAGGLLTGKYKYEDKDGKQPVGR--FFGTQWAEIYRNHFWKEHHFEGIALVEKA 251
              ++PLA G+++GKY      G  P  R    G QW    ++    E      A + K 
Sbjct: 240 AMTWSPLACGIVSGKY----DSGIPPYSRASLKGYQW---LKDKILSEEGRRQQAKL-KE 291

Query: 252 LQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306
           LQA       ++   A+ W      L+     +V+LG S+ +QL +N+ A +  P
Sbjct: 292 LQAIAERLGCTLPQLAIAWC-----LRNEGVSSVLLGASNADQLMENIGAIQVLP 341


>gi|27436969 potassium voltage-gated channel, shaker-related
           subfamily, beta member 2 isoform 2 [Homo sapiens]
          Length = 353

 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 80/295 (27%), Positives = 134/295 (45%), Gaps = 23/295 (7%)

Query: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKAN 79
           G+  D      +T A+ + G    DTA +Y+ G++E +LG +  + G     + I TK  
Sbjct: 48  GQITDEMAEQLMTLAY-DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 106

Query: 80  PWIGNS-----LKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQE 134
            W G +     L    +   L+ SL+RLQ   VD+ + + PD + P+EET+RA   +  +
Sbjct: 107 -WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQ 165

Query: 135 GKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ-VETELFPCLRHFGLR 193
           G  +  G S +++ E+ E  ++ +      P   Q  Y    R+ VE +L       G+ 
Sbjct: 166 GMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVG 225

Query: 194 FYAYNPLAGGLLTGKYKYEDKDGKQPVGR--FFGTQWAEIYRNHFWKEHHFEGIALVEKA 251
              ++PLA G+++GKY      G  P  R    G QW    ++    E      A + K 
Sbjct: 226 AMTWSPLACGIVSGKY----DSGIPPYSRASLKGYQW---LKDKILSEEGRRQQAKL-KE 277

Query: 252 LQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306
           LQA       ++   A+ W      L+     +V+LG S+ +QL +N+ A +  P
Sbjct: 278 LQAIAERLGCTLPQLAIAWC-----LRNEGVSSVLLGASNADQLMENIGAIQVLP 327


>gi|27436964 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 3 [Homo sapiens]
          Length = 401

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 78/296 (26%), Positives = 138/296 (46%), Gaps = 25/296 (8%)

Query: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKAN 79
           G+  D      +T A+ E G    DTA +Y+ G++E ILG +  + G     + I TK  
Sbjct: 96  GQISDEVAERLMTIAY-ESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLY 154

Query: 80  PWIGNS-----LKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQE 134
            W G +     L    +   L+ SL+RLQ   VD+ + + PD + P+EE +RA   +  +
Sbjct: 155 -WGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQ 213

Query: 135 GKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ-VETELFPCLRHFGLR 193
           G  +  G S ++A E+ E  ++ +    I P   Q  Y    R+ VE +L       G+ 
Sbjct: 214 GMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVG 273

Query: 194 FYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAE---IYRNHFWKEHHFEGIALVEK 250
              ++PLA G+++GKY     +  +   + +  QW +   +      +++  + ++ + +
Sbjct: 274 AMTWSPLACGIISGKYGNGVPESSRASLKCY--QWLKERIVSEEGRKQQNKLKDLSPIAE 331

Query: 251 ALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306
            L    G + P +   A+ W      L+     +V+LG S+ EQL +NL A +  P
Sbjct: 332 RL----GCTLPQL---AVAWC-----LRNEGVSSVLLGSSTPEQLIENLGAIQVLP 375


>gi|27436962 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 2 [Homo sapiens]
          Length = 408

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 78/296 (26%), Positives = 138/296 (46%), Gaps = 25/296 (8%)

Query: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKAN 79
           G+  D      +T A+ E G    DTA +Y+ G++E ILG +  + G     + I TK  
Sbjct: 103 GQISDEVAERLMTIAY-ESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLY 161

Query: 80  PWIGNS-----LKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQE 134
            W G +     L    +   L+ SL+RLQ   VD+ + + PD + P+EE +RA   +  +
Sbjct: 162 -WGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQ 220

Query: 135 GKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ-VETELFPCLRHFGLR 193
           G  +  G S ++A E+ E  ++ +    I P   Q  Y    R+ VE +L       G+ 
Sbjct: 221 GMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVG 280

Query: 194 FYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAE---IYRNHFWKEHHFEGIALVEK 250
              ++PLA G+++GKY     +  +   + +  QW +   +      +++  + ++ + +
Sbjct: 281 AMTWSPLACGIISGKYGNGVPESSRASLKCY--QWLKERIVSEEGRKQQNKLKDLSPIAE 338

Query: 251 ALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306
            L    G + P +   A+ W      L+     +V+LG S+ EQL +NL A +  P
Sbjct: 339 RL----GCTLPQL---AVAWC-----LRNEGVSSVLLGSSTPEQLIENLGAIQVLP 382


>gi|27436966 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 1 [Homo sapiens]
          Length = 419

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 78/296 (26%), Positives = 138/296 (46%), Gaps = 25/296 (8%)

Query: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKAN 79
           G+  D      +T A+ E G    DTA +Y+ G++E ILG +  + G     + I TK  
Sbjct: 114 GQISDEVAERLMTIAY-ESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLY 172

Query: 80  PWIGNS-----LKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQE 134
            W G +     L    +   L+ SL+RLQ   VD+ + + PD + P+EE +RA   +  +
Sbjct: 173 -WGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQ 231

Query: 135 GKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ-VETELFPCLRHFGLR 193
           G  +  G S ++A E+ E  ++ +    I P   Q  Y    R+ VE +L       G+ 
Sbjct: 232 GMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVG 291

Query: 194 FYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAE---IYRNHFWKEHHFEGIALVEK 250
              ++PLA G+++GKY     +  +   + +  QW +   +      +++  + ++ + +
Sbjct: 292 AMTWSPLACGIISGKYGNGVPESSRASLKCY--QWLKERIVSEEGRKQQNKLKDLSPIAE 349

Query: 251 ALQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306
            L    G + P +   A+ W      L+     +V+LG S+ EQL +NL A +  P
Sbjct: 350 RL----GCTLPQL---AVAWC-----LRNEGVSSVLLGSSTPEQLIENLGAIQVLP 393


>gi|27436971 potassium voltage-gated channel, shaker-related
           subfamily, beta member 3 [Homo sapiens]
          Length = 404

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 79/292 (27%), Positives = 124/292 (42%), Gaps = 22/292 (7%)

Query: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGL----GLRMGSSDCRVKIA 75
           G ++   T+  V     E G    DTA +Y+ G++E  LG +    G R  S     KI 
Sbjct: 102 GSQISDETAEDVLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVITTKIF 161

Query: 76  TKANPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQEG 135
                     L    +   L  SL+RLQ   VD+ + +  D + P+EE +RA   +  +G
Sbjct: 162 WGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFANRSDPNCPMEEIVRAMTYVINQG 221

Query: 136 KFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ-VETELFPCLRHFGLRF 194
             +  G S + A E+ E  ++ +    I P   Q  +    R+ VE +L       G+  
Sbjct: 222 LALYWGTSRWGAAEIMEAYSMARQFNLIPPVCEQAEHHLFQREKVEMQLPELYHKIGVGS 281

Query: 195 YAYNPLAGGLLTGKYKYEDKDGKQP---VGRFFGTQWAEIYRNHFWKEHHFEGIALVEKA 251
             + PLA GL+T KY     DG+ P        G QW    ++    E   +  A V   
Sbjct: 282 VTWYPLACGLITSKY-----DGRVPDTCRASIKGYQW---LKDKVQSEDGKKQQAKVMDL 333

Query: 252 LQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAE 303
           L  A+     ++   A+ W      L+     +V+LG+SS EQL ++L A +
Sbjct: 334 LPVAHQLGC-TVAQLAIAWC-----LRSEGVSSVLLGVSSAEQLIEHLGALQ 379


>gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens]
          Length = 323

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 50/146 (34%), Positives = 69/146 (47%), Gaps = 17/146 (11%)

Query: 24  DAPTSAAV--TRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVK---IATKA 78
           + P S A+  T+  +E G   ID+A LY++ +      GL +R   +D  VK   I   +
Sbjct: 28  EVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQV----GLAIRSKIADGSVKREDIFYTS 83

Query: 79  NPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQEGKFV 138
             W  NS +P+ VR  LE SLK LQ   VDL+ +H P    P EE +       + GK +
Sbjct: 84  KLWC-NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVI----PKDENGKIL 138

Query: 139 ELGLSNYAAWEVAEICT---LCKSNG 161
              +   A WE  E C    L KS G
Sbjct: 139 FDTVDLCATWEAVEKCKDAGLAKSIG 164


>gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens]
          Length = 323

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 47/137 (34%), Positives = 65/137 (47%), Gaps = 15/137 (10%)

Query: 31  VTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVK---IATKANPWIGNSLK 87
           VT+  +E G   ID+A+LY++ +      GL +R   +D  VK   I   +  W     +
Sbjct: 37  VTKLAIEAGFRHIDSAYLYNNEEQV----GLAIRSKIADGSVKREDIFYTSKLWC-TFFQ 91

Query: 88  PDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAA 147
           P  V+  LE+SLK+LQ   VDL+ LH P    P E  L       + GK +   +   A 
Sbjct: 92  PQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPL----PKDENGKVIFDTVDLSAT 147

Query: 148 WEVAEICT---LCKSNG 161
           WEV E C    L KS G
Sbjct: 148 WEVMEKCKDAGLAKSIG 164


>gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens]
          Length = 323

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 48/146 (32%), Positives = 68/146 (46%), Gaps = 17/146 (11%)

Query: 24  DAPTSAAV--TRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVK---IATKA 78
           + P S A+   +  +E G   ID+A +Y++ +      GL +R   +D  VK   I   +
Sbjct: 28  EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQV----GLAIRSKIADGSVKREDIFYTS 83

Query: 79  NPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQEGKFV 138
             W  NS +P+ VR  LE SLK LQ   VDL+ +H P    P EE +       + GK +
Sbjct: 84  KLW-SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVI----PKDENGKIL 138

Query: 139 ELGLSNYAAWEVAEICT---LCKSNG 161
              +   A WE  E C    L KS G
Sbjct: 139 FDTVDLCATWEAMEKCKDAGLAKSIG 164


>gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens]
          Length = 323

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 48/146 (32%), Positives = 68/146 (46%), Gaps = 17/146 (11%)

Query: 24  DAPTSAAV--TRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVK---IATKA 78
           + P S A+   +  +E G   ID+A +Y++ +      GL +R   +D  VK   I   +
Sbjct: 28  EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQV----GLAIRSKIADGSVKREDIFYTS 83

Query: 79  NPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQEGKFV 138
             W  NS +P+ VR  LE SLK LQ   VDL+ +H P    P EE +       + GK +
Sbjct: 84  KLW-SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVI----PKDENGKIL 138

Query: 139 ELGLSNYAAWEVAEICT---LCKSNG 161
              +   A WE  E C    L KS G
Sbjct: 139 FDTVDLCATWEAMEKCKDAGLAKSIG 164


>gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens]
          Length = 323

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 47/146 (32%), Positives = 66/146 (45%), Gaps = 17/146 (11%)

Query: 24  DAPTSAA--VTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVK---IATKA 78
           + P S A  VT+  +E G   ID+A LY++ +      GL +R   +D  VK   I   +
Sbjct: 28  EVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQV----GLAIRSKIADGSVKREDIFYTS 83

Query: 79  NPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQEGKFV 138
             W     +P+ VR  LE SLK+ Q   VDL+ +H+P    P EE         + GK +
Sbjct: 84  KLW-STFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEE----LSPTDENGKVI 138

Query: 139 ELGLSNYAAWEVAEICT---LCKSNG 161
              +     WE  E C    L KS G
Sbjct: 139 FDIVDLCTTWEAMEKCKDAGLAKSIG 164


>gi|207028673 hypothetical protein LOC100134257 [Homo sapiens]
          Length = 139

 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 34/97 (35%), Positives = 50/97 (51%), Gaps = 10/97 (10%)

Query: 24  DAPTSAAV--TRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVK---IATKA 78
           + P S A+   +  +E G   ID+A +Y++ +      GL +R   +D  VK   I   +
Sbjct: 28  EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQV----GLAIRSKIADGSVKREDIFYTS 83

Query: 79  NPWIGNSLKPDSVRSQLETSLKRLQCPUVDLFYLHAP 115
             W  NS +P+ VR  LE SLK LQ   VDL+ +H P
Sbjct: 84  KLW-SNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119


>gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]
          Length = 325

 Score = 36.6 bits (83), Expect = 0.032
 Identities = 46/192 (23%), Positives = 76/192 (39%), Gaps = 30/192 (15%)

Query: 30  AVTRAFLERGHTEIDTAFLYSDGQS--ETILGGLGLRMGSSDCRVKIATKANPWIGNSLK 87
           A  +  L  G+  ID A +Y +     E +   +G   G +  R ++   +  W      
Sbjct: 31  AAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVG--PGKAVPREELFVTSKLW-NTKHH 87

Query: 88  PDSVRSQLETSLKRLQCPUVDLFYLHAP------DHSAP-------------VEETLRAC 128
           P+ V   L  +L  LQ   +DL+ +H P      D+  P              +ET +A 
Sbjct: 88  PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKAL 147

Query: 129 HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLR 188
             L  +G    LGLSN+ + ++ +I ++      + P V Q          + EL    +
Sbjct: 148 EALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQ--VECHPYLAQNELIAHCQ 201

Query: 189 HFGLRFYAYNPL 200
             GL   AY+PL
Sbjct: 202 ARGLEVTAYSPL 213


>gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]
          Length = 325

 Score = 36.6 bits (83), Expect = 0.032
 Identities = 46/192 (23%), Positives = 76/192 (39%), Gaps = 30/192 (15%)

Query: 30  AVTRAFLERGHTEIDTAFLYSDGQS--ETILGGLGLRMGSSDCRVKIATKANPWIGNSLK 87
           A  +  L  G+  ID A +Y +     E +   +G   G +  R ++   +  W      
Sbjct: 31  AAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVG--PGKAVPREELFVTSKLW-NTKHH 87

Query: 88  PDSVRSQLETSLKRLQCPUVDLFYLHAP------DHSAP-------------VEETLRAC 128
           P+ V   L  +L  LQ   +DL+ +H P      D+  P              +ET +A 
Sbjct: 88  PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKAL 147

Query: 129 HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLR 188
             L  +G    LGLSN+ + ++ +I ++      + P V Q          + EL    +
Sbjct: 148 EALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQ--VECHPYLAQNELIAHCQ 201

Query: 189 HFGLRFYAYNPL 200
             GL   AY+PL
Sbjct: 202 ARGLEVTAYSPL 213


>gi|148529025 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4B [Homo sapiens]
          Length = 1271

 Score = 35.0 bits (79), Expect = 0.093
 Identities = 29/100 (29%), Positives = 47/100 (47%), Gaps = 5/100 (5%)

Query: 10   PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEI-DTAFLYSDGQSETILGGLGLRMGSS 68
            P +++   E   R     S++   A  +R H+ I D++   S  QS +ILG LGL + SS
Sbjct: 1158 PDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSSSILGSLGLLVSSS 1217

Query: 69   DCRVKIATKA-NPW---IGNSLKPDSVRSQLETSLKRLQC 104
                 + + A +PW   I   ++ D    +LET  +   C
Sbjct: 1218 PAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAVC 1257


>gi|71999153 hypothetical protein LOC23334 [Homo sapiens]
          Length = 2533

 Score = 30.0 bits (66), Expect = 3.0
 Identities = 21/51 (41%), Positives = 25/51 (49%), Gaps = 3/51 (5%)

Query: 283 DAVILG-MSSLEQLEQNLAAAEEGPL--EPAVVDAFNQAWHLFAHECPNYF 330
           DA  +G M S E L Q   + E GPL  EP V D  +Q      HE P +F
Sbjct: 101 DAACIGSMLSFEYLIQLCQSKEWGPLPPEPRVSDGLDQGGDTCVHEIPFHF 151


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,523,841
Number of Sequences: 37866
Number of extensions: 519822
Number of successful extensions: 1174
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1134
Number of HSP's gapped (non-prelim): 21
length of query: 331
length of database: 18,247,518
effective HSP length: 103
effective length of query: 228
effective length of database: 14,347,320
effective search space: 3271188960
effective search space used: 3271188960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.