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Search of human proteins with 223278403
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
(1211 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 2432 0.0
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 200 6e-51
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 192 1e-48
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 189 1e-47
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 189 1e-47
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 184 3e-46
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 184 3e-46
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 172 2e-42
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 172 2e-42
gi|33356148 formin-like 1 [Homo sapiens] 161 4e-39
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 155 2e-37
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 155 2e-37
gi|145309324 FH2 domain containing 1 [Homo sapiens] 153 1e-36
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 144 5e-34
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 144 5e-34
gi|52485606 formin-like 2 [Homo sapiens] 135 3e-31
gi|157168329 formin 1 [Homo sapiens] 131 3e-30
gi|160707881 formin 2 [Homo sapiens] 124 5e-28
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 91 5e-18
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 86 3e-16
gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo ... 68 6e-11
gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo... 68 6e-11
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 64 7e-10
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 64 9e-10
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 63 2e-09
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo... 61 7e-09
gi|150418009 transforming, acidic coiled-coil containing protein... 61 7e-09
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 60 1e-08
gi|126090663 zinc finger homeodomain 4 [Homo sapiens] 60 2e-08
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 59 4e-08
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 2432 bits (6303), Expect = 0.0
Identities = 1211/1211 (100%), Positives = 1211/1211 (100%)
Query: 1 MATTATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGL 60
MATTATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGL
Sbjct: 1 MATTATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGL 60
Query: 61 SRERLVRLARRCPRVPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGLALGRELLRL 120
SRERLVRLARRCPRVPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGLALGRELLRL
Sbjct: 61 SRERLVRLARRCPRVPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGLALGRELLRL 120
Query: 121 AGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVWTLTL 180
AGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVWTLTL
Sbjct: 121 AGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVWTLTL 180
Query: 181 ALPREACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPE 240
ALPREACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPE
Sbjct: 181 ALPREACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPE 240
Query: 241 RLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVW 300
RLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVW
Sbjct: 241 RLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVW 300
Query: 301 IESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFA 360
IESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFA
Sbjct: 301 IESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFA 360
Query: 361 SDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFF 420
SDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFF
Sbjct: 361 SDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFF 420
Query: 421 QHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPE 480
QHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPE
Sbjct: 421 QHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPE 480
Query: 481 LDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDG 540
LDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDG
Sbjct: 481 LDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDG 540
Query: 541 TSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSW 600
TSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSW
Sbjct: 541 TSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSW 600
Query: 601 PSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTR 660
PSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTR
Sbjct: 601 PSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTR 660
Query: 661 PPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFV 720
PPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFV
Sbjct: 661 PPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFV 720
Query: 721 TNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGP 780
TNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGP
Sbjct: 721 TNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGP 780
Query: 781 AQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVEN 840
AQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVEN
Sbjct: 781 AQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVEN 840
Query: 841 SEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKA 900
SEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKA
Sbjct: 841 SEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKA 900
Query: 901 YNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRL 960
YNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRL
Sbjct: 901 YNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRL 960
Query: 961 SEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL 1020
SEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL
Sbjct: 961 SEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL 1020
Query: 1021 EFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLG 1080
EFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLG
Sbjct: 1021 EFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLG 1080
Query: 1081 FAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ 1140
FAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ
Sbjct: 1081 FAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ 1140
Query: 1141 PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGL 1200
PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGL
Sbjct: 1141 PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGL 1200
Query: 1201 RSSGMVSPLAW 1211
RSSGMVSPLAW
Sbjct: 1201 RSSGMVSPLAW 1211
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 200 bits (509), Expect = 6e-51
Identities = 156/514 (30%), Positives = 239/514 (46%), Gaps = 79/514 (15%)
Query: 724 RSSASDCISSSEEGSSLTYSSISDHIPPPP-----LS--------PPPPPPLPFHDAKPS 770
R ++ ++ E S+ SS PPPP LS PPPPPPLPF P
Sbjct: 501 RGQVAELVAQLSELSTGPVSS-----PPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPP- 554
Query: 771 SRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLG----------- 819
P PPP PP PP P APP L GL
Sbjct: 555 -----------------------PPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDV 591
Query: 820 ----HRRSETSHMSVKRLRWEQV--ENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGT 873
R + SH +K W ++ E GT+W ++ +D ++ D+ D E F
Sbjct: 592 PLRKKRVPQPSH-PLKSFNWVKLNEERVPGTVWNEI-DDMQVFRILDLE---DFEKMFSA 646
Query: 874 -QKPAKPVPGPEPF----RKKEVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRR 928
Q+ K + E RK + + ++ ++A N ILL+ LKLS E+RQ ++ M+ +
Sbjct: 647 YQRHQKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQE 706
Query: 929 -LEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQA 987
L L QLL F P+ + + + R++ D+F+ +M + Y+ RL++L F+
Sbjct: 707 DLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKK 766
Query: 988 TLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINF 1047
QE+ E + +E + AS EL S++L ++LE +LA+GN++N GQ GF++
Sbjct: 767 KFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQ--RGGAYGFRVAS 824
Query: 1048 LTELNSTK-TVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTSDLADL 1106
L ++ TK ++D + LH L L +HFP++L +L +P AAKVN L ++ +L
Sbjct: 825 LNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNL 884
Query: 1107 HGTISEIQ----DACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQREAMEELGKALA 1162
+ ++ Q PS DKF VMS F+ + + L+ EA ++ KAL
Sbjct: 885 RRGLRAVEVLEYQRRQVREPS--DKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALM 942
Query: 1163 FFGEDSKATTSEAFFGIFAEFMSKFERALSDLQA 1196
FGE + FFGIF F+ F A DL+A
Sbjct: 943 HFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEA 976
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 192 bits (489), Expect = 1e-48
Identities = 137/470 (29%), Positives = 226/470 (48%), Gaps = 55/470 (11%)
Query: 749 IPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPP--PPPPPLPPP 806
+P L PPPPPPLP P P+PP PPPPP PPP
Sbjct: 544 VPGSLLPPPPPPPLPGGMLPPPPP---------------------PLPPGGPPPPPGPPP 582
Query: 807 VPCA--PPMLSRGLGHRRSETSHMS--VKRLRWEQVENS--EGTIWGQLGEDSDYDKLSD 860
+ PP GL ++ + +K W ++ + EGT+W ++ +D+ K+ D
Sbjct: 583 LGAIMPPPGAPMGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEI-DDTKVFKILD 641
Query: 861 MVKYLDLELHFGT--------------QKPAKPVPGPEPFRKK-EVVEILSHKKAYNTSI 905
+ DLE F QK A + + K + + ++ ++A N +I
Sbjct: 642 LE---DLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNI 698
Query: 906 LLAHLKLSPAELRQVLMSMEPRRLEPAH-LAQLLLFAPDADEEQRYQAFREAPGRLSEPD 964
LL+ LKLS E+++ +++M+ + P L QLL F P+ + + + R+++ D
Sbjct: 699 LLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKAD 758
Query: 965 QFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVL 1024
+F+ +M + Y+ RL+SL+F+ E+ E++ +E +R S E+ S L ++LE VL
Sbjct: 759 RFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVL 818
Query: 1025 AMGNYLNDGQPKTNKTTGFKINFLTELNSTK-TVDGKSTFLHILAKSLSQHFPELLGFAQ 1083
A GNY+N GQ GFKI+ L ++ TK ++D T LH L + +P +L +
Sbjct: 819 AFGNYMNKGQ--RGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNE 876
Query: 1084 DLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQ---SISPSSEDKFAMVMSSFLETAQ 1140
+L +P AAKVN L +++ L + ++ + S P DKF V+S F+ A
Sbjct: 877 ELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVAS 936
Query: 1141 PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERA 1190
+ ++ L EA + KA+ FGE++ + FFGIF +F+ A
Sbjct: 937 FSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEA 986
Score = 34.7 bits (78), Expect = 0.57
Identities = 34/117 (29%), Positives = 46/117 (39%), Gaps = 23/117 (19%)
Query: 545 ETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSE- 603
ET K + A+L ++L+ ++ + + P GPSP GP +PS
Sbjct: 497 ETTEHKQVKQQVADLTAQLH-----ELSRRAVCASIPGGPSPGAPGGP-------FPSSV 544
Query: 604 --RLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDP 658
LLP P PL GG+ P P P P PGP P+ PP P
Sbjct: 545 PGSLLPPPPPPPL-PGGMLPPPPPPLPP-------GGPPPPPGPPPLGAIMPPPGAP 593
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 189 bits (481), Expect = 1e-47
Identities = 147/481 (30%), Positives = 227/481 (47%), Gaps = 46/481 (9%)
Query: 744 SISDHIPPPPLSPP-----PPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPP 798
S S IP PP +PP PPPP P A P + P PL + +PPP
Sbjct: 543 SSSSGIPGPPAAPPLPGVGPPPPPP---APPLPGGA-----PLPPPPPPLPGMMG-IPPP 593
Query: 799 PPPPL-------PPPVPCAPPM------LSRGLGHRRSETSHMSVKRLRWEQVEN---SE 842
PPPPL PPP+ PP L G+ ++ +S+KR+ W ++E SE
Sbjct: 594 PPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSE 653
Query: 843 GTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQ----KPAKPVP----GPEPFRKKEVVEI 894
W ++ ED K + + L L+F TQ K A+ + GP + KE+ I
Sbjct: 654 NCFWLRVKED----KFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKEL-RI 708
Query: 895 LSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFR 954
L K A N SI L ++ ++R V++ + L A + L+ P+ +
Sbjct: 709 LDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELK 768
Query: 955 EAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSR 1014
L EP+QF + M SV + RL S+ F+ T +E I+ S+ + A ELK S
Sbjct: 769 NEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSE 828
Query: 1015 KLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQH 1074
++LE VL +GNY+N G + ++ GFKINFL ++ TK+ D K+T LH +A +
Sbjct: 829 SFNRLLELVLLVGNYMNSGS-RNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEK 887
Query: 1075 FPELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSI--SPSSEDKFAMVM 1132
+ ++L F ++L V A+KV+ + L S+LA + I ++ + + + DKF M
Sbjct: 888 YRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKM 947
Query: 1133 SSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALS 1192
+SF +TA+ L + M+ +F DSK + E FFG F + F A+
Sbjct: 948 TSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVR 1007
Query: 1193 D 1193
+
Sbjct: 1008 E 1008
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 189 bits (481), Expect = 1e-47
Identities = 147/481 (30%), Positives = 227/481 (47%), Gaps = 46/481 (9%)
Query: 744 SISDHIPPPPLSPP-----PPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPP 798
S S IP PP +PP PPPP P A P + P PL + +PPP
Sbjct: 543 SSSSGIPGPPAAPPLPGVGPPPPPP---APPLPGGA-----PLPPPPPPLPGMMG-IPPP 593
Query: 799 PPPPL-------PPPVPCAPPM------LSRGLGHRRSETSHMSVKRLRWEQVEN---SE 842
PPPPL PPP+ PP L G+ ++ +S+KR+ W ++E SE
Sbjct: 594 PPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSE 653
Query: 843 GTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQ----KPAKPVP----GPEPFRKKEVVEI 894
W ++ ED K + + L L+F TQ K A+ + GP + KE+ I
Sbjct: 654 NCFWLRVKED----KFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKEL-RI 708
Query: 895 LSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFR 954
L K A N SI L ++ ++R V++ + L A + L+ P+ +
Sbjct: 709 LDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELK 768
Query: 955 EAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSR 1014
L EP+QF + M SV + RL S+ F+ T +E I+ S+ + A ELK S
Sbjct: 769 NEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSE 828
Query: 1015 KLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQH 1074
++LE VL +GNY+N G + ++ GFKINFL ++ TK+ D K+T LH +A +
Sbjct: 829 SFNRLLELVLLVGNYMNSGS-RNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEK 887
Query: 1075 FPELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSI--SPSSEDKFAMVM 1132
+ ++L F ++L V A+KV+ + L S+LA + I ++ + + + DKF M
Sbjct: 888 YRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKM 947
Query: 1133 SSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALS 1192
+SF +TA+ L + M+ +F DSK + E FFG F + F A+
Sbjct: 948 TSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVR 1007
Query: 1193 D 1193
+
Sbjct: 1008 E 1008
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 184 bits (468), Expect = 3e-46
Identities = 132/461 (28%), Positives = 226/461 (49%), Gaps = 49/461 (10%)
Query: 749 IPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPL----- 803
+PPPP PPPPPPLP G R P S PVPPPPP
Sbjct: 324 VPPPP-PPPPPPPLP------------GMRMP----------FSGPVPPPPPLGFLGGQN 360
Query: 804 PPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQV---ENSEGTIWGQLGEDSDYDKLSD 860
PP+P P GL ++ +S++RL W ++ E +E W ++ E+ Y+ +
Sbjct: 361 SPPLPILP----FGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENK-YENVDL 415
Query: 861 MVKYLDLELHFGTQKPAK----PVPGPEPFRKK-EVVEILSHKKAYNTSILLAHLKLSPA 915
+ K LE F Q+ + + + +KK + ++ L K A N SI L+ ++
Sbjct: 416 LCK---LENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYE 472
Query: 916 ELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPE 975
E+R +++ ++ RL + + L+ PD ++ F+ L EP+QFV+ M +V
Sbjct: 473 EIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKR 532
Query: 976 YKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQP 1035
+ RL ++ F+ +E+ I+ + + A E+K S+ +K+LE VL MGNY+N G
Sbjct: 533 LRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGS- 591
Query: 1036 KTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVN 1095
+ +T GF ++ L +L TK+ D K+T LH L + + +P++L F DL + A+KV+
Sbjct: 592 RNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVS 651
Query: 1096 QRALTSDLADLHGTISEIQDACQSISPSSE--DKFAMVMSSFLETAQPALRALDGLQREA 1153
L +L + + +++ ++ P + DKF MS F+ +A+ L L E
Sbjct: 652 VETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKL-HEN 710
Query: 1154 MEELGKA-LAFFGEDSKATTSEAFFGIFAEFMSKFERALSD 1193
ME+L ++ + ++ D K + E F F + F +A+ +
Sbjct: 711 MEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKE 751
Score = 32.0 bits (71), Expect = 3.7
Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 15/103 (14%)
Query: 606 LPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRR 665
LP+ C PL PS +++L P P P G + P PP P P P R
Sbjct: 291 LPADCNIPL------PPSKEGGTGHSALPP---PPPLPSGGGVPPPPPPPPPPPLPGMR- 340
Query: 666 KLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYE 708
FS PV L L Q P + I+ L P+ +++
Sbjct: 341 --MPFSGPVPPPPP---LGFLGGQNSPPLPILPFGLKPKKEFK 378
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 184 bits (468), Expect = 3e-46
Identities = 132/461 (28%), Positives = 226/461 (49%), Gaps = 49/461 (10%)
Query: 749 IPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPL----- 803
+PPPP PPPPPPLP G R P S PVPPPPP
Sbjct: 587 VPPPP-PPPPPPPLP------------GMRMP----------FSGPVPPPPPLGFLGGQN 623
Query: 804 PPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQV---ENSEGTIWGQLGEDSDYDKLSD 860
PP+P P GL ++ +S++RL W ++ E +E W ++ E+ Y+ +
Sbjct: 624 SPPLPILP----FGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENK-YENVDL 678
Query: 861 MVKYLDLELHFGTQKPAK----PVPGPEPFRKK-EVVEILSHKKAYNTSILLAHLKLSPA 915
+ K LE F Q+ + + + +KK + ++ L K A N SI L+ ++
Sbjct: 679 LCK---LENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYE 735
Query: 916 ELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPE 975
E+R +++ ++ RL + + L+ PD ++ F+ L EP+QFV+ M +V
Sbjct: 736 EIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKR 795
Query: 976 YKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQP 1035
+ RL ++ F+ +E+ I+ + + A E+K S+ +K+LE VL MGNY+N G
Sbjct: 796 LRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGS- 854
Query: 1036 KTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVN 1095
+ +T GF ++ L +L TK+ D K+T LH L + + +P++L F DL + A+KV+
Sbjct: 855 RNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVS 914
Query: 1096 QRALTSDLADLHGTISEIQDACQSISPSSE--DKFAMVMSSFLETAQPALRALDGLQREA 1153
L +L + + +++ ++ P + DKF MS F+ +A+ L L E
Sbjct: 915 VETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKL-HEN 973
Query: 1154 MEELGKA-LAFFGEDSKATTSEAFFGIFAEFMSKFERALSD 1193
ME+L ++ + ++ D K + E F F + F +A+ +
Sbjct: 974 MEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKE 1014
Score = 32.0 bits (71), Expect = 3.7
Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 15/103 (14%)
Query: 606 LPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRR 665
LP+ C PL PS +++L P P P G + P PP P P P R
Sbjct: 554 LPADCNIPL------PPSKEGGTGHSALPP---PPPLPSGGGVPPPPPPPPPPPLPGMR- 603
Query: 666 KLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYE 708
FS PV L L Q P + I+ L P+ +++
Sbjct: 604 --MPFSGPVPPPPP---LGFLGGQNSPPLPILPFGLKPKKEFK 641
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 172 bits (435), Expect = 2e-42
Identities = 136/472 (28%), Positives = 220/472 (46%), Gaps = 47/472 (9%)
Query: 750 PPPPLS-----PPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPP-L 803
PPPPL PPPPPPLP P G G +PPPPP +
Sbjct: 694 PPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPG---------------IPPPPPGMGM 738
Query: 804 PPPVPC-----APPMLSRGLGHRRSETSHMSVKRLRWEQV---ENSEGTIWGQLGEDSDY 855
PPP P A P+L GL ++ + ++R W ++ + S+ W ++ ED
Sbjct: 739 PPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKED--- 795
Query: 856 DKLSDMVKYLDLELHFGTQ----KPAKPVPGPEP---FRKKEVVE--ILSHKKAYNTSIL 906
+ + + L L F Q K K G E +KK+V E +L K A N SI
Sbjct: 796 -RFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIF 854
Query: 907 LAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQF 966
L ++ E++ V++ + L + + L+ P+ ++ + ++ L+E +QF
Sbjct: 855 LGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQF 914
Query: 967 VLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAM 1026
+ M +VP + RL ++ F+ E+ E I+ + + A EL+ S + +LE L +
Sbjct: 915 GVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLV 974
Query: 1027 GNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLP 1086
GNY+N G + GF I+FL +L TK+ D K T LH LA+ +P++L F +L
Sbjct: 975 GNYMNAGS-RNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 1033
Query: 1087 TVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSE--DKFAMVMSSFLETAQPALR 1144
V A++V+ L +L + IS+++ Q+ +++ DKF M+SF++ AQ
Sbjct: 1034 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1093
Query: 1145 ALDGLQREAMEELGKALA-FFGEDSKATTSEAFFGIFAEFMSKFERALSDLQ 1195
L + ME L K L +F D K + E FF F + F +A+ + Q
Sbjct: 1094 KL-RMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQ 1144
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/63 (42%), Positives = 27/63 (42%), Gaps = 5/63 (7%)
Query: 750 PPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPC 809
PPPP PPPPPPLP S S G P LS PPPPPLP V
Sbjct: 600 PPPPPPPPPPPPLPGGVCISSPPSLPGGTA-----ISPPPPLSGDATIPPPPPLPEGVGI 654
Query: 810 APP 812
P
Sbjct: 655 PSP 657
Score = 43.1 bits (100), Expect = 0.002
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 16/90 (17%)
Query: 733 SSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLS 792
+ +E +SL+ ++I+ +PP S P PP P P S P A T
Sbjct: 549 AKKEMASLSAAAIT--VPPSVPSRAPVPPAP-----PLPGDSGTIIPPPPAPGDSTT--- 598
Query: 793 HPVPPPPPPPLPPPVP-----CAPPMLSRG 817
P PPPPPPP PPP+P +PP L G
Sbjct: 599 -PPPPPPPPPPPPPLPGGVCISSPPSLPGG 627
Score = 33.9 bits (76), Expect = 0.96
Identities = 48/167 (28%), Positives = 58/167 (34%), Gaps = 49/167 (29%)
Query: 520 PSECPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRA 579
PS P P P +PG+ GT +P P P G T
Sbjct: 568 PSRAPVPPAPPLPGD----SGTIIPPPPAP-------------------GDSTTPPPPPP 604
Query: 580 SPPGPSP----AVTTGPRTLSG---VSWP----SERLLPSPCYHPLCSG-GLASPSS--- 624
PP P P + P +L G +S P + +P P PL G G+ SPSS
Sbjct: 605 PPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPP--PPLPEGVGIPSPSSLPG 662
Query: 625 -SESHPYASLDSSRA----PSPQPGPGPICPDSPPSPD----PTRPP 662
+ P L S P P PG I P PP P P PP
Sbjct: 663 GTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 709
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 172 bits (435), Expect = 2e-42
Identities = 136/472 (28%), Positives = 220/472 (46%), Gaps = 47/472 (9%)
Query: 750 PPPPLS-----PPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPP-L 803
PPPPL PPPPPPLP P G G +PPPPP +
Sbjct: 703 PPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPG---------------IPPPPPGMGM 747
Query: 804 PPPVPC-----APPMLSRGLGHRRSETSHMSVKRLRWEQV---ENSEGTIWGQLGEDSDY 855
PPP P A P+L GL ++ + ++R W ++ + S+ W ++ ED
Sbjct: 748 PPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKED--- 804
Query: 856 DKLSDMVKYLDLELHFGTQ----KPAKPVPGPEP---FRKKEVVE--ILSHKKAYNTSIL 906
+ + + L L F Q K K G E +KK+V E +L K A N SI
Sbjct: 805 -RFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIF 863
Query: 907 LAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQF 966
L ++ E++ V++ + L + + L+ P+ ++ + ++ L+E +QF
Sbjct: 864 LGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQF 923
Query: 967 VLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAM 1026
+ M +VP + RL ++ F+ E+ E I+ + + A EL+ S + +LE L +
Sbjct: 924 GVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLV 983
Query: 1027 GNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLP 1086
GNY+N G + GF I+FL +L TK+ D K T LH LA+ +P++L F +L
Sbjct: 984 GNYMNAGS-RNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 1042
Query: 1087 TVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSE--DKFAMVMSSFLETAQPALR 1144
V A++V+ L +L + IS+++ Q+ +++ DKF M+SF++ AQ
Sbjct: 1043 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1102
Query: 1145 ALDGLQREAMEELGKALA-FFGEDSKATTSEAFFGIFAEFMSKFERALSDLQ 1195
L + ME L K L +F D K + E FF F + F +A+ + Q
Sbjct: 1103 KL-RMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQ 1153
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/63 (42%), Positives = 27/63 (42%), Gaps = 5/63 (7%)
Query: 750 PPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPC 809
PPPP PPPPPPLP S S G P LS PPPPPLP V
Sbjct: 609 PPPPPPPPPPPPLPGGVCISSPPSLPGGTA-----ISPPPPLSGDATIPPPPPLPEGVGI 663
Query: 810 APP 812
P
Sbjct: 664 PSP 666
Score = 43.1 bits (100), Expect = 0.002
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 16/90 (17%)
Query: 733 SSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLS 792
+ +E +SL+ ++I+ +PP S P PP P P S P A T
Sbjct: 558 AKKEMASLSAAAIT--VPPSVPSRAPVPPAP-----PLPGDSGTIIPPPPAPGDSTT--- 607
Query: 793 HPVPPPPPPPLPPPVP-----CAPPMLSRG 817
P PPPPPPP PPP+P +PP L G
Sbjct: 608 -PPPPPPPPPPPPPLPGGVCISSPPSLPGG 636
Score = 33.9 bits (76), Expect = 0.96
Identities = 48/167 (28%), Positives = 58/167 (34%), Gaps = 49/167 (29%)
Query: 520 PSECPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRA 579
PS P P P +PG+ GT +P P P G T
Sbjct: 577 PSRAPVPPAPPLPGD----SGTIIPPPPAP-------------------GDSTTPPPPPP 613
Query: 580 SPPGPSP----AVTTGPRTLSG---VSWP----SERLLPSPCYHPLCSG-GLASPSS--- 624
PP P P + P +L G +S P + +P P PL G G+ SPSS
Sbjct: 614 PPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPP--PPLPEGVGIPSPSSLPG 671
Query: 625 -SESHPYASLDSSRA----PSPQPGPGPICPDSPPSPD----PTRPP 662
+ P L S P P PG I P PP P P PP
Sbjct: 672 GTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 718
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 161 bits (407), Expect = 4e-39
Identities = 127/465 (27%), Positives = 203/465 (43%), Gaps = 38/465 (8%)
Query: 752 PPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAP 811
PP +PP PPLP P + G P P PVPPPPPPP PP P P
Sbjct: 558 PPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPP--PPPPGGP 615
Query: 812 PMLSRGLGHRRSET-----------SHMSVKRLRWEQVENSE--GTIWGQLGEDSDYDKL 858
P LG R SE + + L W ++ S+ GT++ +L ++ +L
Sbjct: 616 P---DALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQEL 672
Query: 859 SDMVKYLDLELHFGTQKPA-----KPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLS 913
DM D E F T+ + + ++ +A N +I L L
Sbjct: 673 -DMS---DFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLG 728
Query: 914 PAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQ---RYQAFREAPGRLSEPDQFVLQM 970
+ Q + + + + L L L+ F P E R++ + LSE D+F+L
Sbjct: 729 AERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCF 788
Query: 971 LSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYL 1030
+P R+ +L F + + + L + AS+ +K+S KL +ILE VLA GNY+
Sbjct: 789 SRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYM 848
Query: 1031 NDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPL 1090
N K GF++ L L K+ D K T LH L K +++ +P+L GF DL +
Sbjct: 849 NSS--KRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDK 906
Query: 1091 AAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQ 1150
A V+ ++ +D+ L + + Q +D MV+ FL P + L
Sbjct: 907 AGSVSLDSVLADVRSLQRGL----ELTQREFVRQDD--CMVLKEFLRANSPTMDKLLADS 960
Query: 1151 REAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQ 1195
+ A E + +FGE+ K T+ FF +F+ F+ +++A +++
Sbjct: 961 KTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVE 1005
Score = 36.2 bits (82), Expect = 0.19
Identities = 29/92 (31%), Positives = 33/92 (35%), Gaps = 7/92 (7%)
Query: 572 GTVSKSRASPPGPSP-AVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPY 630
G+ S A P+P A P L G+ P E +P P P S E P
Sbjct: 524 GSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAP------PLPGSPEPPPA 577
Query: 631 ASLDSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
L P P P P P D P P P PP
Sbjct: 578 PPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPP 609
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 155 bits (393), Expect = 2e-37
Identities = 139/512 (27%), Positives = 219/512 (42%), Gaps = 78/512 (15%)
Query: 750 PPPPL---------SPPPPPPLPFHDAKPSSRSSDGSRGPAQ-ALAKPLTQLSHPVP--- 796
PPPPL PPPPPPLP AK + P A+A P L P+P
Sbjct: 425 PPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSC 484
Query: 797 ---------------PPPPPPL---------PPPVP-----CAPPM-----------LSR 816
PPPPPPL PPP P C+PP+ +
Sbjct: 485 EFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDH 544
Query: 817 GLG------HRRSETSHMSVKRLRWEQ----VENSEGTIWGQLGEDSDYDKLSDMVKYLD 866
GLG HRR + +K+L W++ V ++W L D + + ++
Sbjct: 545 GLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSP-DAEAVEPDFSSIE 603
Query: 867 LELHFGTQKPAKP-VPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSME 925
F KP +P + P ++ + + L KK+ N +I L K S E+ ++ + +
Sbjct: 604 RLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGD 663
Query: 926 PRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHF 985
+ + L QLL P+ E + +AF E +L+ D F L +L++P Y+ R+ +
Sbjct: 664 TTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLL 723
Query: 986 QATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKI 1045
+ +R + + A L SR+L + +L +GN+LN G T GFKI
Sbjct: 724 CEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGS-HTGDADGFKI 782
Query: 1046 NFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTSDLAD 1105
+ L +L TK+ + T LH + + + P+LL +DL AA +N + S+ +
Sbjct: 783 STLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEAS- 841
Query: 1106 LHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ---PALRALDGLQREAMEELGKALA 1162
+ ++ + + +S S A V + E Q A RALD L EA+E+ + LA
Sbjct: 842 --SNLKKLLETERKVSAS----VAEVQEQYTERLQASISAFRALDEL-FEAIEQKQRELA 894
Query: 1163 -FFGEDSKATTSEAFFGIFAEFMSKFERALSD 1193
+ ED++ + E F F F RAL +
Sbjct: 895 DYLCEDAQQLSLEDTFSTMKAFRDLFLRALKE 926
Score = 35.8 bits (81), Expect = 0.25
Identities = 18/39 (46%), Positives = 21/39 (53%), Gaps = 7/39 (17%)
Query: 786 KPLTQLSHPVPPPPPPPL-------PPPVPCAPPMLSRG 817
+ L Q + PPPPPPPL PPP P PP+ S G
Sbjct: 412 RALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG 450
Score = 33.5 bits (75), Expect = 1.3
Identities = 33/137 (24%), Positives = 49/137 (35%), Gaps = 20/137 (14%)
Query: 542 SLPETPNPKMMSAVYAELESRLNSSFKGKMG---TVSKSRASPPGPSPAVTTGP------ 592
S+ P P + + +++ L+ S +G T K P+ A P
Sbjct: 343 SVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQS 402
Query: 593 RTLSGVSWP-----SERLLPSPCYHPLCSGGLASPSSSESHP------YASLDSSRAPSP 641
++ VS P P P PL G A P P +L ++ P P
Sbjct: 403 ESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPP 462
Query: 642 QPGPGPICPDSPPSPDP 658
PG G + P +PP P P
Sbjct: 463 LPGLGAMAPPAPPLPPP 479
Score = 33.5 bits (75), Expect = 1.3
Identities = 49/193 (25%), Positives = 58/193 (30%), Gaps = 67/193 (34%)
Query: 478 EPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQA 537
+P EP Q S L+ S + + LE S P P P PL+PG
Sbjct: 387 QPAAAAACEPVDHAQSESILKVS-------QPRALEQQASTPP---PPPPPPLLPGS--- 433
Query: 538 GDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSG 597
P P P + +V G + A PP P P + G
Sbjct: 434 --SAEPPPPPPPPPLPSV----------------GAKALPTAPPPPPLPGL--------G 467
Query: 598 VSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPP--- 654
P LP P P S E P P P P PG CP PP
Sbjct: 468 AMAPPAPPLPPPL-----------PGSCEFLP---------PPPPPLPGLGCPPPPPPLL 507
Query: 655 -----SPDPTRPP 662
P P PP
Sbjct: 508 PGMGWGPPPPPPP 520
Score = 31.2 bits (69), Expect = 6.3
Identities = 25/83 (30%), Positives = 30/83 (36%), Gaps = 6/83 (7%)
Query: 580 SPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAP 639
S G SP TT P+ P+ P H L S P A L+ +
Sbjct: 367 SQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESIL-----KVSQPRA-LEQQAST 420
Query: 640 SPQPGPGPICPDSPPSPDPTRPP 662
P P P P+ P S P P PP
Sbjct: 421 PPPPPPPPLLPGSSAEPPPPPPP 443
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 155 bits (393), Expect = 2e-37
Identities = 139/512 (27%), Positives = 219/512 (42%), Gaps = 78/512 (15%)
Query: 750 PPPPL---------SPPPPPPLPFHDAKPSSRSSDGSRGPAQ-ALAKPLTQLSHPVP--- 796
PPPPL PPPPPPLP AK + P A+A P L P+P
Sbjct: 425 PPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSC 484
Query: 797 ---------------PPPPPPL---------PPPVP-----CAPPM-----------LSR 816
PPPPPPL PPP P C+PP+ +
Sbjct: 485 EFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDH 544
Query: 817 GLG------HRRSETSHMSVKRLRWEQ----VENSEGTIWGQLGEDSDYDKLSDMVKYLD 866
GLG HRR + +K+L W++ V ++W L D + + ++
Sbjct: 545 GLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSP-DAEAVEPDFSSIE 603
Query: 867 LELHFGTQKPAKP-VPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSME 925
F KP +P + P ++ + + L KK+ N +I L K S E+ ++ + +
Sbjct: 604 RLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGD 663
Query: 926 PRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHF 985
+ + L QLL P+ E + +AF E +L+ D F L +L++P Y+ R+ +
Sbjct: 664 TTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLL 723
Query: 986 QATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKI 1045
+ +R + + A L SR+L + +L +GN+LN G T GFKI
Sbjct: 724 CEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGS-HTGDADGFKI 782
Query: 1046 NFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTSDLAD 1105
+ L +L TK+ + T LH + + + P+LL +DL AA +N + S+ +
Sbjct: 783 STLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEAS- 841
Query: 1106 LHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ---PALRALDGLQREAMEELGKALA 1162
+ ++ + + +S S A V + E Q A RALD L EA+E+ + LA
Sbjct: 842 --SNLKKLLETERKVSAS----VAEVQEQYTERLQASISAFRALDEL-FEAIEQKQRELA 894
Query: 1163 -FFGEDSKATTSEAFFGIFAEFMSKFERALSD 1193
+ ED++ + E F F F RAL +
Sbjct: 895 DYLCEDAQQLSLEDTFSTMKAFRDLFLRALKE 926
Score = 35.8 bits (81), Expect = 0.25
Identities = 18/39 (46%), Positives = 21/39 (53%), Gaps = 7/39 (17%)
Query: 786 KPLTQLSHPVPPPPPPPL-------PPPVPCAPPMLSRG 817
+ L Q + PPPPPPPL PPP P PP+ S G
Sbjct: 412 RALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG 450
Score = 33.5 bits (75), Expect = 1.3
Identities = 33/137 (24%), Positives = 49/137 (35%), Gaps = 20/137 (14%)
Query: 542 SLPETPNPKMMSAVYAELESRLNSSFKGKMG---TVSKSRASPPGPSPAVTTGP------ 592
S+ P P + + +++ L+ S +G T K P+ A P
Sbjct: 343 SVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQS 402
Query: 593 RTLSGVSWP-----SERLLPSPCYHPLCSGGLASPSSSESHP------YASLDSSRAPSP 641
++ VS P P P PL G A P P +L ++ P P
Sbjct: 403 ESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPP 462
Query: 642 QPGPGPICPDSPPSPDP 658
PG G + P +PP P P
Sbjct: 463 LPGLGAMAPPAPPLPPP 479
Score = 33.5 bits (75), Expect = 1.3
Identities = 49/193 (25%), Positives = 58/193 (30%), Gaps = 67/193 (34%)
Query: 478 EPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQA 537
+P EP Q S L+ S + + LE S P P P PL+PG
Sbjct: 387 QPAAAAACEPVDHAQSESILKVS-------QPRALEQQASTPP---PPPPPPLLPGS--- 433
Query: 538 GDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSG 597
P P P + +V G + A PP P P + G
Sbjct: 434 --SAEPPPPPPPPPLPSV----------------GAKALPTAPPPPPLPGL--------G 467
Query: 598 VSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPP--- 654
P LP P P S E P P P P PG CP PP
Sbjct: 468 AMAPPAPPLPPPL-----------PGSCEFLP---------PPPPPLPGLGCPPPPPPLL 507
Query: 655 -----SPDPTRPP 662
P P PP
Sbjct: 508 PGMGWGPPPPPPP 520
Score = 31.2 bits (69), Expect = 6.3
Identities = 25/83 (30%), Positives = 30/83 (36%), Gaps = 6/83 (7%)
Query: 580 SPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAP 639
S G SP TT P+ P+ P H L S P A L+ +
Sbjct: 367 SQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESIL-----KVSQPRA-LEQQAST 420
Query: 640 SPQPGPGPICPDSPPSPDPTRPP 662
P P P P+ P S P P PP
Sbjct: 421 PPPPPPPPLLPGSSAEPPPPPPP 443
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 153 bits (386), Expect = 1e-36
Identities = 131/478 (27%), Positives = 201/478 (42%), Gaps = 40/478 (8%)
Query: 731 ISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQ 790
+S E G+ T PPP PPPPPP P PS P + ++
Sbjct: 10 VSDKENGNIATAPGFMIGQTPPPAPPPPPPPPP-----PS---------PPCSCSREECP 55
Query: 791 LSHPVPPPPP----PPLPPPVPCAPPMLS-RGLGH--RRSETSHMSVKRLRWEQVENSEG 843
S P PPPPP PP+PPP P PP G H ++ K + EQV
Sbjct: 56 SSPPPPPPPPLPGEPPIPPPPPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTN 115
Query: 844 TIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPE-------PFRK-KEVVEIL 895
IW + ++ +E FG Q+ P FR+ +E + IL
Sbjct: 116 -IWTLAARQEHHYQIDTKT----IEELFGQQEDTTKSSLPRRGRTLNSSFREAREEITIL 170
Query: 896 SHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFRE 955
K++ N I L K SP + + + + L + L F P+++E ++ +AF
Sbjct: 171 DAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSG 230
Query: 956 APGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRK 1015
+LS D F+ ++ VP Y R+ ++ + + + LR A EL + +
Sbjct: 231 DVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEE 290
Query: 1016 LAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHF 1075
L IL VL GN +N G N GFK++ L +L TK LH +A+ +
Sbjct: 291 LHSILHLVLQAGNIMNAGGYAGN-AVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKD 349
Query: 1076 PELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSF 1135
LL F++ L V A++ +L + A+LH + ++I E M F
Sbjct: 350 TILLNFSEKLHHVQKTARL---SLENTEAELHLLFVRTKSLKENIQRDGE--LCQQMEDF 404
Query: 1136 LETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSD 1193
L+ A LR L+ ++E +E + FF ED K + F IF +F +KF +A+ D
Sbjct: 405 LQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKD 462
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 144 bits (363), Expect = 5e-34
Identities = 129/476 (27%), Positives = 205/476 (43%), Gaps = 80/476 (16%)
Query: 750 PPP----PLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPP 805
PPP PL PPP PPLP PPPPPLP
Sbjct: 459 PPPEEVLPLPPPPAPPLP----------------------------------PPPPPLPD 484
Query: 806 PVPCAPPM--------LSRGLGHRRSETSHMSVKRL---RWEQVENSE--GTIWGQLG-- 850
P APP+ L+ GL R + + RL W ++ ++ GT++ +L
Sbjct: 485 KCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDE 544
Query: 851 ---EDSDYDKLSDMVKYLD----LELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNT 903
ED D DK ++ K L+L K A+ + V +L +A N
Sbjct: 545 KILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQ--------KAASKVTLLEANRAKNL 596
Query: 904 SILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQ---RYQAFREAPGRL 960
+I L S E+ + + + + + L + L+ F P E + +Y+ R+ L
Sbjct: 597 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL 656
Query: 961 SEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL 1020
+ D+F+L V R+ + F Q+ + + L + AS +K+S+KL ++L
Sbjct: 657 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML 716
Query: 1021 EFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLG 1080
E +LA+GNY+N K GFK+ L L TK+ D K T LH +A ++ + +P+L
Sbjct: 717 EIILALGNYMNSS--KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLAN 774
Query: 1081 FAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ 1140
F +L V AA V+ + D+ +L + I+ C SI +S V+ +FL T +
Sbjct: 775 FWHELHFVEKAAAVSLENVLLDVKELGRGMELIRREC-SIHDNS------VLRNFLSTNE 827
Query: 1141 PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQA 1196
L L + A E + +FGE K T FF +F F+ ++ A + +A
Sbjct: 828 GKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEA 883
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 144 bits (363), Expect = 5e-34
Identities = 129/476 (27%), Positives = 205/476 (43%), Gaps = 80/476 (16%)
Query: 750 PPP----PLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPP 805
PPP PL PPP PPLP PPPPPLP
Sbjct: 510 PPPEEVLPLPPPPAPPLP----------------------------------PPPPPLPD 535
Query: 806 PVPCAPPM--------LSRGLGHRRSETSHMSVKRL---RWEQVENSE--GTIWGQLG-- 850
P APP+ L+ GL R + + RL W ++ ++ GT++ +L
Sbjct: 536 KCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDE 595
Query: 851 ---EDSDYDKLSDMVKYLD----LELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNT 903
ED D DK ++ K L+L K A+ + V +L +A N
Sbjct: 596 KILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQ--------KAASKVTLLEANRAKNL 647
Query: 904 SILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQ---RYQAFREAPGRL 960
+I L S E+ + + + + + L + L+ F P E + +Y+ R+ L
Sbjct: 648 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL 707
Query: 961 SEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL 1020
+ D+F+L V R+ + F Q+ + + L + AS +K+S+KL ++L
Sbjct: 708 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML 767
Query: 1021 EFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLG 1080
E +LA+GNY+N K GFK+ L L TK+ D K T LH +A ++ + +P+L
Sbjct: 768 EIILALGNYMNSS--KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLAN 825
Query: 1081 FAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ 1140
F +L V AA V+ + D+ +L + I+ C SI +S V+ +FL T +
Sbjct: 826 FWHELHFVEKAAAVSLENVLLDVKELGRGMELIRREC-SIHDNS------VLRNFLSTNE 878
Query: 1141 PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQA 1196
L L + A E + +FGE K T FF +F F+ ++ A + +A
Sbjct: 879 GKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEA 934
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 135 bits (339), Expect = 3e-31
Identities = 114/473 (24%), Positives = 204/473 (43%), Gaps = 53/473 (11%)
Query: 756 PPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLP----------- 804
PPPPPPLP P + + P P P PPPPPPPLP
Sbjct: 527 PPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPP 586
Query: 805 --PPVPCAPPM---------LSRGLGHRRSETSHMSVKRL---RWEQVENSE--GTIWGQ 848
PP+P APP+ + GL + + + R+ W ++ ++ GT++ +
Sbjct: 587 LAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNE 646
Query: 849 LG-----EDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPE---PFRKKEVVEILSHKKA 900
+ ED + D+ ++ K Q PA + + P + V +L +A
Sbjct: 647 IDDERILEDLNVDEFEEIFKTK-------AQGPAIDLSSSKQKIPQKGSNKVTLLEANRA 699
Query: 901 YNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQ---RYQAFREAP 957
N +I L + E+ + + + + L + L+ F P +E + Y+ R+
Sbjct: 700 KNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPL 759
Query: 958 GRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLA 1017
LS+ D+F++Q + ++ + F E + + L + AS+ +K+S+KL
Sbjct: 760 ENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLK 819
Query: 1018 KILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPE 1077
KILE +LA+GNY+N K GFK+ L L TK+ D K T LH ++ + + + +
Sbjct: 820 KILEIILALGNYMNSS--KRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQ 877
Query: 1078 LLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLE 1137
+ F +L V AA V+ + D+ +L + + ++ ++ F+
Sbjct: 878 VSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNT------LLKEFIL 931
Query: 1138 TAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERA 1190
+ L+ L + A + + +FGE+ K T FF +F F+ +++A
Sbjct: 932 NNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQA 984
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 131 bits (330), Expect = 3e-30
Identities = 117/511 (22%), Positives = 205/511 (40%), Gaps = 86/511 (16%)
Query: 749 IPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPP-- 806
+PPPP S PPPPPLP S GS PA + P PPPPPPPLPPP
Sbjct: 645 LPPPPASIPPPPPLP---------SGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSS 695
Query: 807 ---------------------------------VPCAPPMLSRGLGHRRSETSHMS---- 829
P PP L GLG S+
Sbjct: 696 AGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCPRKPAIEP 755
Query: 830 ---VKRLRWEQVE------NSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPV 880
+K L W +++ N+ T+W L E + D ++ L TQ+ KP+
Sbjct: 756 SCPMKPLYWTRIQISDRSQNATPTLWDSLEEPD----IRDPSEFEYLFSKDTTQQKKKPL 811
Query: 881 PGPEPFRKK----EVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQ 936
E + KK +++++L K++ IL++ L L +++Q + +++ ++ LA
Sbjct: 812 S--ETYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDLETLAA 869
Query: 937 LLLFAPDADEEQRYQAFREAPGR-----LSEPDQFVLQMLSVPEYKTRLRSLHFQATLQE 991
L DE + + + E L +P+QF+ ++ +P + R + + F++ E
Sbjct: 870 LYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSE 929
Query: 992 KTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTEL 1051
+ +E + +AS +L + + + IL +LA GNY+N G + G+ + L +L
Sbjct: 930 GITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKL 989
Query: 1052 NSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVP------LAAKVNQRALTSDL-- 1103
K+ D + + K +++ + G + + +P LA++V L DL
Sbjct: 990 KDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVKFEDLIKDLRK 1049
Query: 1104 --ADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQREAMEELGKAL 1161
L + ++ C+ F + F + A+ + + A + +
Sbjct: 1050 LKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKMEESHLENAQKSFETTV 1109
Query: 1162 AFFG----EDSKATTSEAFFGIFAEFMSKFE 1188
+FG K T F ++ EF S F+
Sbjct: 1110 RYFGMKPKSGEKEITPSYVFMVWYEFCSDFK 1140
Score = 39.7 bits (91), Expect = 0.018
Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 6/100 (6%)
Query: 563 LNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASP 622
++++ + G S + + P P ++ P SG+ L P+P P+ +G P
Sbjct: 627 IHAALQPMEGMASNQQKALPPPPASIPPPPPLPSGLG----SLSPAPPMPPVSAGPPLPP 682
Query: 623 SSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
P SS P P P P P+ P+SP P+P PP
Sbjct: 683 PPPPPPPLPP-PSSAGPPPPPPPPPL-PNSPAPPNPGGPP 720
Score = 38.1 bits (87), Expect = 0.051
Identities = 31/109 (28%), Positives = 42/109 (38%), Gaps = 20/109 (18%)
Query: 561 SRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYH-----PLC 615
+R N K+ S S+ SPP + + + G++ ++ LP P PL
Sbjct: 600 TRSNQLVPKKLNISSLSQLSPPNDHKDIHAALQPMEGMASNQQKALPPPPASIPPPPPLP 659
Query: 616 SG-GLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPS 663
SG G SP+ P P GP P PP P P PPS
Sbjct: 660 SGLGSLSPAP--------------PMPPVSAGPPLPPPPPPPPPLPPPS 694
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 124 bits (311), Expect = 5e-28
Identities = 130/499 (26%), Positives = 209/499 (41%), Gaps = 68/499 (13%)
Query: 749 IPPPPLSP----PPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPP----- 799
IPPPP P PPPPPLP P PA A PL +PPPP
Sbjct: 1184 IPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPA--PPLPPPGTGIPPPPLLPVS 1241
Query: 800 -PP--------PLPPPVPCA---PPMLSR--GLGHRRSETSHMS-------VKRLRWEQV 838
PP LP P C PP+ S GLG + + S +K L W ++
Sbjct: 1242 GPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRI 1301
Query: 839 E------NSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGP-EPFRKKEV 891
+ +S IW ++ E S D ++ +L ++ KP+ + K+V
Sbjct: 1302 QLHSKRDSSTSLIWEKIEEPS-----IDCHEFEELFSKTAVKERKKPISDTISKTKAKQV 1356
Query: 892 VEILSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQ 951
V++LS+K++ IL++ L L +++ +++++ ++ L L +DE ++ +
Sbjct: 1357 VKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIE 1416
Query: 952 AF------REAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQ 1005
+E L +P+QF+ ++ +P + R+ + FQ+T E IR LE L++
Sbjct: 1417 KHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQK 1476
Query: 1006 ASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLH 1065
LKN + ++L VLA GNY+N G + GF ++ L +L K+ D + L
Sbjct: 1477 LCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLS 1536
Query: 1066 ILAKSLSQHFPELLGFAQDLPTVP------LAAKVNQRALTSDL----ADLHGTISEIQD 1115
+ ++F E G Q L +P A+++ DL DL E
Sbjct: 1537 YIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGK 1596
Query: 1116 ACQSISPSSEDKFAMVMSSFLETAQPALRALDGLQREAMEELGKALAFF------GEDSK 1169
Q S F M F+ A+ A + E + + A+F GE K
Sbjct: 1597 VYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGE--K 1654
Query: 1170 ATTSEAFFGIFAEFMSKFE 1188
+ AFF I+ EF S F+
Sbjct: 1655 EVSPNAFFSIWHEFSSDFK 1673
Score = 44.7 bits (104), Expect = 5e-04
Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 13/110 (11%)
Query: 713 HDDQGSFVTNERSSASDCISSSEEGSS---LTYSSISDHIPPPPLSPPPPPPLPFHDAKP 769
H F T+ S S +S S L + S +P + PPPPPPLP
Sbjct: 831 HSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPT 890
Query: 770 SSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLP-PPVPCAPPMLSRGL 818
P+ A+ +P + PPPPPPLP +P PP+ G+
Sbjct: 891 L---------PSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGI 931
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/89 (35%), Positives = 37/89 (41%), Gaps = 19/89 (21%)
Query: 749 IPPPPLSP----PPPPPLPFHDAKPSSRSSDGSRGPAQAL-------AKPLTQLSHPVPP 797
IPPPP P PPPPPLP P P L PL ++ P PP
Sbjct: 1096 IPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPP 1155
Query: 798 -------PPPPPLP-PPVPCAPPMLSRGL 818
PPPPPLP +P PP+ G+
Sbjct: 1156 PLPGAGIPPPPPLPGAGIPPPPPLPGVGI 1184
Score = 44.3 bits (103), Expect = 7e-04
Identities = 31/82 (37%), Positives = 34/82 (41%), Gaps = 16/82 (19%)
Query: 749 IPPPPLSP----PPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPP------- 797
IPPPP P PPPPPLP P P PL P PP
Sbjct: 1019 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP----PPPLPGAGIPPPPPLPGAGI 1074
Query: 798 PPPPPLP-PPVPCAPPMLSRGL 818
PPPPPLP +P PP+ G+
Sbjct: 1075 PPPPPLPGAGIPPPPPLPGAGI 1096
Score = 43.5 bits (101), Expect = 0.001
Identities = 31/82 (37%), Positives = 34/82 (41%), Gaps = 16/82 (19%)
Query: 749 IPPPPLSP----PPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPP------- 797
IPPPP P PPPPPLP P P PL P PP
Sbjct: 1085 IPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPP----PPPLPGAGIPPPPPLPGAGI 1140
Query: 798 PPPPPLP-PPVPCAPPMLSRGL 818
PPPPPLP +P PP+ G+
Sbjct: 1141 PPPPPLPRVGIPPPPPLPGAGI 1162
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/89 (35%), Positives = 36/89 (40%), Gaps = 19/89 (21%)
Query: 749 IPPPPLSP----PPPPPLPFHDAKPSSRSSDGSRGPAQALAK-------PLTQLSHPVPP 797
IPPPP P PPPPPLP P P L + PL P PP
Sbjct: 1107 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPP 1166
Query: 798 P-------PPPPLP-PPVPCAPPMLSRGL 818
P PPPPLP +P PP+ G+
Sbjct: 1167 PLPGAGIPPPPPLPGVGIPPPPPLPGVGI 1195
Score = 42.0 bits (97), Expect = 0.004
Identities = 31/82 (37%), Positives = 34/82 (41%), Gaps = 16/82 (19%)
Query: 749 IPPPPLSP----PPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPP--- 801
IPPPP P PPPPPLP P P PL P PPP P
Sbjct: 975 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP----PLPGAGIPPPPPLPGAGI 1030
Query: 802 PLPPPVPCA-----PPMLSRGL 818
P PPP+P A PP+ G+
Sbjct: 1031 PPPPPLPGAGIPPPPPLPGAGI 1052
Score = 42.0 bits (97), Expect = 0.004
Identities = 31/81 (38%), Positives = 31/81 (38%), Gaps = 14/81 (17%)
Query: 749 IPPPPLSP----PPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPP------ 798
IPPPP P PPPPPLP P P PL P PPP
Sbjct: 1041 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP----PLPGAGIPPPPPLPGAGI 1096
Query: 799 PPPPLPPPVPCAPPMLSRGLG 819
PPPP P V PP G G
Sbjct: 1097 PPPPPLPGVGIPPPPPLPGAG 1117
Score = 41.6 bits (96), Expect = 0.005
Identities = 34/93 (36%), Positives = 38/93 (40%), Gaps = 27/93 (29%)
Query: 749 IPPPPLSP---------------PPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSH 793
IPPPP P PPPPPLP A P G+ P L PL
Sbjct: 920 IPPPPPLPGAGILPLPPLPGAGIPPPPPLP-GAAIPPPPPLPGAGIP---LPPPLPGAGI 975
Query: 794 PVPP-------PPPPPLP-PPVPCAPPMLSRGL 818
P PP PPPPPLP +P PP+ G+
Sbjct: 976 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1008
Score = 41.2 bits (95), Expect = 0.006
Identities = 29/89 (32%), Positives = 36/89 (40%), Gaps = 19/89 (21%)
Query: 749 IPPPPLSP----PPPPPLP-----FHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPP 799
IPPPP P PPPPPLP P + P + P +PPPP
Sbjct: 942 IPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1001
Query: 800 PPP---LPPP-------VPCAPPMLSRGL 818
P P +PPP +P PP+ G+
Sbjct: 1002 PLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1030
Score = 40.0 bits (92), Expect = 0.013
Identities = 31/84 (36%), Positives = 35/84 (41%), Gaps = 23/84 (27%)
Query: 751 PPPLS-----PPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPP---- 801
PPPL PPPPPPLP P P + PL L PPPPP
Sbjct: 899 PPPLQGTEMLPPPPPPLPGAGIPPPPPL------PGAGIL-PLPPLPGAGIPPPPPLPGA 951
Query: 802 --PLPPPVPCA-----PPMLSRGL 818
P PPP+P A PP+ G+
Sbjct: 952 AIPPPPPLPGAGIPLPPPLPGAGI 975
Score = 33.5 bits (75), Expect = 1.3
Identities = 28/93 (30%), Positives = 34/93 (36%), Gaps = 13/93 (13%)
Query: 581 PPGPSPAVTTGPRTLSGVSWP-----SERLLPSPCYHPLCSGGLASPSSSESH---PYAS 632
PP P P +T + + P +E L P P PL G+ P P
Sbjct: 879 PPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPP--PPLPGAGIPPPPPLPGAGILPLPP 936
Query: 633 LDSSRAPSPQPGPGPICPDSPPSPD---PTRPP 662
L + P P P PG P PP P P PP
Sbjct: 937 LPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPP 969
Score = 33.1 bits (74), Expect = 1.6
Identities = 29/89 (32%), Positives = 32/89 (35%), Gaps = 7/89 (7%)
Query: 581 PPGPSP-AVTTGPRTLSGVSWPSERLLPS---PCYHPLCSGGLASPS---SSESHPYASL 633
PP P P A P L G P LP P PL G+ P + P L
Sbjct: 944 PPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1003
Query: 634 DSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
+ P P P PG P PP P PP
Sbjct: 1004 PGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1032
Score = 32.7 bits (73), Expect = 2.1
Identities = 25/80 (31%), Positives = 31/80 (38%), Gaps = 8/80 (10%)
Query: 745 ISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPP--- 801
+ H P +S PPPPP A + GS+ P + T H V
Sbjct: 798 LDSHQPTQSISQPPPPPSLLWSA---GQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCN 854
Query: 802 -PLPPPVPCAPPMLSR-GLG 819
P PPP+PC S GLG
Sbjct: 855 IPSPPPLPCTESSSSMPGLG 874
Score = 32.3 bits (72), Expect = 2.8
Identities = 29/89 (32%), Positives = 32/89 (35%), Gaps = 7/89 (7%)
Query: 581 PPGPSP-AVTTGPRTLSGVSWPSERLLPS---PCYHPLCSGGLASPS---SSESHPYASL 633
PP P P A P L G P LP P PL G+ P + P L
Sbjct: 977 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1036
Query: 634 DSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
+ P P P PG P PP P PP
Sbjct: 1037 PGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1065
Score = 32.3 bits (72), Expect = 2.8
Identities = 29/89 (32%), Positives = 32/89 (35%), Gaps = 7/89 (7%)
Query: 581 PPGPSP-AVTTGPRTLSGVSWPSERLLPS---PCYHPLCSGGLASPS---SSESHPYASL 633
PP P P A P L G P LP P PL G+ P + P L
Sbjct: 988 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1047
Query: 634 DSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
+ P P P PG P PP P PP
Sbjct: 1048 PGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1076
Score = 32.3 bits (72), Expect = 2.8
Identities = 29/89 (32%), Positives = 32/89 (35%), Gaps = 7/89 (7%)
Query: 581 PPGPSP-AVTTGPRTLSGVSWPSERLLPS---PCYHPLCSGGLASPS---SSESHPYASL 633
PP P P A P L G P LP P PL G+ P + P L
Sbjct: 999 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1058
Query: 634 DSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
+ P P P PG P PP P PP
Sbjct: 1059 PGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1087
Score = 32.3 bits (72), Expect = 2.8
Identities = 29/89 (32%), Positives = 32/89 (35%), Gaps = 7/89 (7%)
Query: 581 PPGPSP-AVTTGPRTLSGVSWPSERLLPS---PCYHPLCSGGLASPS---SSESHPYASL 633
PP P P A P L G P LP P PL G+ P + P L
Sbjct: 1010 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1069
Query: 634 DSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
+ P P P PG P PP P PP
Sbjct: 1070 PGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1098
Score = 32.3 bits (72), Expect = 2.8
Identities = 29/89 (32%), Positives = 31/89 (34%), Gaps = 7/89 (7%)
Query: 581 PPGPSPAV-TTGPRTLSGVSWPSERLLPS---PCYHPLCSGGLASPSSSES---HPYASL 633
PP P P V P L G P LP P PL G+ P P L
Sbjct: 1098 PPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPL 1157
Query: 634 DSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
+ P P P PG P PP P PP
Sbjct: 1158 PGAGIPPPPPLPGAGIPPPPPLPGVGIPP 1186
Score = 32.0 bits (71), Expect = 3.7
Identities = 29/89 (32%), Positives = 31/89 (34%), Gaps = 7/89 (7%)
Query: 581 PPGPSP-AVTTGPRTLSGVSWPSERLLPS---PCYHPLCSGGLASPSSSES---HPYASL 633
PP P P A P L G P LP P PL G+ P P L
Sbjct: 1054 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPL 1113
Query: 634 DSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
+ P P P PG P PP P PP
Sbjct: 1114 PGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1142
Score = 31.6 bits (70), Expect = 4.8
Identities = 28/89 (31%), Positives = 31/89 (34%), Gaps = 7/89 (7%)
Query: 581 PPGPSPAVTTG-PRTLSGVSWPSERLLPS---PCYHPLCSGGLASPS---SSESHPYASL 633
PP P P P L G P LP P PL G+ P + P L
Sbjct: 955 PPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1014
Query: 634 DSSRAPSPQPGPGPICPDSPPSPDPTRPP 662
+ P P P PG P PP P PP
Sbjct: 1015 PGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1043
Score = 30.8 bits (68), Expect = 8.2
Identities = 26/85 (30%), Positives = 30/85 (35%), Gaps = 12/85 (14%)
Query: 581 PPGPSPAVTTGPRTLSGVSWPSERLLPS---PCYHPLCSGGLASPSSSESHPYASLDSSR 637
PP P + P L G + P LP P PL G+ P L +
Sbjct: 935 PPLPGAGIPPPP-PLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPP--------LPGAG 985
Query: 638 APSPQPGPGPICPDSPPSPDPTRPP 662
P P P PG P PP P PP
Sbjct: 986 IPPPPPLPGAGIPPPPPLPGAGIPP 1010
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 91.3 bits (225), Expect = 5e-18
Identities = 108/479 (22%), Positives = 189/479 (39%), Gaps = 81/479 (16%)
Query: 756 PPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPL-----PPPVPC- 809
PPPPPP F +PPPPPPPL PPPVP
Sbjct: 846 PPPPPPPTFLG----------------------------LPPPPPPPLLDSIPPPPVPGN 877
Query: 810 ----APPMLS--RGLGHRR------SETSHMSVKRLRWEQVENSEGT----------IWG 847
PP+ + +GLG + + T RL W +V + +W
Sbjct: 878 LLVPPPPVFNAPQGLGWSQVPRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWS 937
Query: 848 QLGEDS-DYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSIL 906
+L D +L + + EL + A K++ + +L K++ +I
Sbjct: 938 KLEPIKVDTSRLEHLFESKSKELSVSKKTAADG--------KRQEIIVLDSKRSNAINIG 989
Query: 907 LAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGR--LSEPD 964
L L P ++ +++ + L + ++L P +E+Q+ Q + A L +
Sbjct: 990 LTVLP-PPRTIKIAILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAE 1048
Query: 965 QFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVL 1024
QF+L + S+ E RL F+ + +E+ L L++ +L+N++ L IL +L
Sbjct: 1049 QFLLTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLL 1108
Query: 1025 AMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQD 1084
A+GN+LN K F++++L ++ K K + LH + + ++FP+ +
Sbjct: 1109 AIGNFLNGTNAK-----AFELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSE 1163
Query: 1085 LPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISP-SSEDKFAMVMSSFLETAQPAL 1143
+ + +AKV+ L +L + D ++I+ + MS FL+ +
Sbjct: 1164 IGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERI 1223
Query: 1144 RALDGLQREAMEELGKALAFFGEDSKA---TTSEAFFGIFAEFMSKF----ERALSDLQ 1195
L + R + L F G A F I +EF ++ ER L Q
Sbjct: 1224 IILKIVHRRIINRFHSFLLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQ 1282
Score = 30.8 bits (68), Expect = 8.2
Identities = 22/64 (34%), Positives = 32/64 (50%), Gaps = 3/64 (4%)
Query: 111 LALGRELLRLAGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQR 170
LA RE R +R + RE R K FSR + +Q A+E+ + L+Q AAE+
Sbjct: 455 LAAERERRRQEREERLQRIEREERNK---FSRDYLDKREEQRQAREERYKYLEQLAAEEH 511
Query: 171 VDDL 174
+L
Sbjct: 512 EKEL 515
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 85.5 bits (210), Expect = 3e-16
Identities = 131/577 (22%), Positives = 217/577 (37%), Gaps = 92/577 (15%)
Query: 622 PSSSES-HPYASLDSSRAPSPQPGPGPICPDSP--------------PSPDPTRPPSRRK 666
PSS E SL+ P+ P PGP P SP P+ P PPS +
Sbjct: 356 PSSEEGKRSRRSLEGGGCPARAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQ 415
Query: 667 ----LFTFSHPVRSRDTD--------RFLD-VLSEQLGPRVTIVD---DFLTPENDYEEM 710
LF S DT RFL+ V + + +V + + L E
Sbjct: 416 ASVNLFPTISVAPSADTSSERSIYKARFLENVAAAETEKQVALAQGRAETLAGAMPNEAG 475
Query: 711 SFHDDQGSFVTNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPP----------- 759
D + + + E + A+ S L P PL P P
Sbjct: 476 GHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTR 535
Query: 760 -PPLPFHDAKPSSRSSD-------------GSRGPAQALAKPLTQLSHPVPP-PPPPPLP 804
P L D S D G PA + PL P PP PPPPP+
Sbjct: 536 APRLSIGDLDFSDLGEDEDQDMLNVESVEAGKDIPAPSPPLPLLSGVPPPPPLPPPPPIK 595
Query: 805 PPVPCAPPM-LSRGLGHRRSETSHMSVKR----LRWEQVENSEG------------TIWG 847
P P PP+ L+ L H ++S + KR L W +++ + G T+W
Sbjct: 596 GPFPPPPPLPLAAPLPHSVPDSSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWA 655
Query: 848 QLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSILL 907
L D +S L+ H + + +P + + + + K N +I +
Sbjct: 656 SL------DPVSVDTARLE---HLFESRAKEVLPSKKAGEGRRTMTTVLDPKRSN-AINI 705
Query: 908 AHLKLSPAE-LRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGR--LSEPD 964
L P ++ L++ + + + +LL P +E Q+ + + A L +
Sbjct: 706 GLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAE 765
Query: 965 QFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVL 1024
F++ + S+ RL+ F+ EI L L+ +L + IL +L
Sbjct: 766 NFLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLL 825
Query: 1025 AMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQD 1084
A+GN+LN Q ++GF++++L +++ K + + LH L + Q PE +
Sbjct: 826 AVGNFLNGSQ-----SSGFELSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSE 880
Query: 1085 LPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSIS 1121
+P + AKV+ LT +L L +++ +S++
Sbjct: 881 IPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLA 917
>gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo
sapiens]
Length = 1376
Score = 67.8 bits (164), Expect = 6e-11
Identities = 36/95 (37%), Positives = 56/95 (58%), Gaps = 1/95 (1%)
Query: 270 LAGPGGAR-RTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAALKSGDRILFLNGLD 328
L GP R R+V V +G +GFTL G P + V+ GSPAD L++GD+IL +N ++
Sbjct: 12 LPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEIN 71
Query: 329 MRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDS 363
++ SH+ VV ++ + +V+ EG+ F S S
Sbjct: 72 VKKASHEDVVKLIGKCSGVLHMVIAEGVGRFESCS 106
Score = 47.8 bits (112), Expect = 6e-05
Identities = 26/59 (44%), Positives = 33/59 (55%)
Query: 17 FGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRERLVRLARRCPRV 75
+GF L G PC + V +GS A GLR GDQIL V + V S E +V+L +C V
Sbjct: 32 YGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGV 90
>gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo
sapiens]
Length = 1447
Score = 67.8 bits (164), Expect = 6e-11
Identities = 36/95 (37%), Positives = 56/95 (58%), Gaps = 1/95 (1%)
Query: 270 LAGPGGAR-RTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAALKSGDRILFLNGLD 328
L GP R R+V V +G +GFTL G P + V+ GSPAD L++GD+IL +N ++
Sbjct: 12 LPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEIN 71
Query: 329 MRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDS 363
++ SH+ VV ++ + +V+ EG+ F S S
Sbjct: 72 VKKASHEDVVKLIGKCSGVLHMVIAEGVGRFESCS 106
Score = 47.8 bits (112), Expect = 6e-05
Identities = 26/59 (44%), Positives = 33/59 (55%)
Query: 17 FGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRERLVRLARRCPRV 75
+GF L G PC + V +GS A GLR GDQIL V + V S E +V+L +C V
Sbjct: 32 YGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGV 90
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 64.3 bits (155), Expect = 7e-10
Identities = 58/209 (27%), Positives = 89/209 (42%), Gaps = 43/209 (20%)
Query: 155 KEQVFAALKQFAAEQRVDDLVWTLTLALPREACGPLLDNLRIFIPKKHRARFDEVVSQGL 214
+EQ L + A + V DLV TL + L LL LR+ IP+ + FD+ ++GL
Sbjct: 55 REQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGL 114
Query: 215 LGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPG 274
A+ P R+P P A GPG
Sbjct: 115 Y------------------------------LPATTPYRQPAWGGPDSA--------GPG 136
Query: 275 GARR-TVRVYKGNKSFGFTLRG---HGP-VWIESVLPGSPADNAALKSGDRILFLNGLDM 329
R ++R K ++ GF++RG HG +++ V PGS A+ L+ GD+IL +N +
Sbjct: 137 EVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSL 196
Query: 330 RNCSHDKVVSMLQGSGAMPTLVVEEGLVP 358
+H + V L+GS + V G +P
Sbjct: 197 ARVTHAEAVKALKGSKKLVLSVYSAGRIP 225
Score = 60.1 bits (144), Expect = 1e-08
Identities = 98/430 (22%), Positives = 155/430 (36%), Gaps = 74/430 (17%)
Query: 274 GGARRTVRVYKGN-KSFGFTLRGHGP----VWIESVLPGSPADNAALKSGDRILFLNGLD 328
GG + V + G+ +S G T+RG ++I V PGS A+ + LK GD+IL +NG
Sbjct: 274 GGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRS 333
Query: 329 MRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFAS--------------------------- 361
N HD+ V +L+ S + V + G +P A
Sbjct: 334 FLNILHDEAVRLLKSSRHLILTVKDVGRLPHARTTVDETKWIASSRIRETMANSAGFLGD 393
Query: 362 -DSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFF 420
++ ++ P Q L + RV +Q HLL E + L+ +
Sbjct: 394 LTTEGINKPGFYKGPAGSQVTLSSLGNQTRV---LLEEQARHLLNEQEHATMAYYLDEYR 450
Query: 421 QHR-NIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEP 479
+++ L++ ++ +L+T AK + LL+ + + + F + + E E
Sbjct: 451 GGSVSVEALVMALFKLLNTHAK-------FSLLSEVRGTISPQDLERF-DHLVLRREIE- 501
Query: 480 ELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGD 539
+ P P S+ + S S S G +S + GE G+
Sbjct: 502 SMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSSARNTLDLEE----TGEAVQGN 557
Query: 540 GTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVS 599
+LP+ + S S+ SSFK P P P L
Sbjct: 558 INALPDVSVDDVRST------SQGLSSFK-----------PLPRPPPLAQGNDLPLGQPR 600
Query: 600 WPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSP--PSPD 657
L P P CSG + S + S P + AP+P P SP S
Sbjct: 601 KLGREDLQPPSSMPSCSGTVFSAPQNRSPP-----AGTAPTPGTSSAQDLPSSPIYASVS 655
Query: 658 PTRPPSRRKL 667
P P S+R L
Sbjct: 656 PANPSSKRPL 665
Score = 35.4 bits (80), Expect = 0.33
Identities = 53/203 (26%), Positives = 77/203 (37%), Gaps = 32/203 (15%)
Query: 28 FVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRERLVRLARRCPRVPPSLGVLPAPDG 87
++ V GS A GL+ GDQILEV G + + + VRL + + +L D
Sbjct: 305 YITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHL-----ILTVKD- 358
Query: 88 GPGPGSGPAAPTTV-----LRAPRCGRGLALGRELLRLAGRKRPDAVHRERRRKAQEFSR 142
G P A TTV + + R +A L G + +++ K S+
Sbjct: 359 ---VGRLPHARTTVDETKWIASSRIRETMANSAGFL---GDLTTEGINKPGFYKGPAGSQ 412
Query: 143 KVDEILGDQPTA----------KEQVFAALKQFAAEQR-----VDDLVWTLTLALPREAC 187
LG+Q EQ A + + E R V+ LV L L A
Sbjct: 413 VTLSSLGNQTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAK 472
Query: 188 GPLLDNLRIFIPKKHRARFDEVV 210
LL +R I + RFD +V
Sbjct: 473 FSLLSEVRGTISPQDLERFDHLV 495
Score = 32.0 bits (71), Expect = 3.7
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 394 RTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLT 453
R Q L LL+ ER L ++ RN+ L+ + +LD+P K+ L + ++
Sbjct: 40 RQLHQALTALLSEAEREQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIP 99
Query: 454 YEEQELCQEKIACFLGYTAMTAEPEPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLE 513
+Q L + A L A T +P + P+ +R S+ RR+ +GL
Sbjct: 100 RSDQLLFDQYTAEGLYLPATTPYRQP-----AWGGPDSAGPGEVRLVSL-RRAKAHEGLG 153
Query: 514 AGLSCGPSECPEMPLPLI-PGERQAGDGTSLPE---TPNPKMMSAV-YAELESRLNSSFK 568
+ G + + L+ PG +G + + N K ++ V +AE L S K
Sbjct: 154 FSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKK 213
Query: 569 GKMGTVSKSR 578
+ S R
Sbjct: 214 LVLSVYSAGR 223
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 63.9 bits (154), Expect = 9e-10
Identities = 102/381 (26%), Positives = 141/381 (37%), Gaps = 80/381 (20%)
Query: 485 SEPTP-EPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEM-PLPLIPGERQAGDGTS 542
S PTP P P +M RRS R+ G E GL P P P P G R++ S
Sbjct: 165 SGPTPGTPSP-------AMARRS-RAAGTEVGL---PRPAPSARPRPPTEGPRKSVSSAS 213
Query: 543 LPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPS 602
T P + L + + + +SP P+ PR + S P
Sbjct: 214 EHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPK 273
Query: 603 ERLLPS--------------PCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPG---- 644
+ L + P PL S LA+PS P A+L S +AP P
Sbjct: 274 PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS-----PSAALQS-QAPPTLPATPHS 327
Query: 645 ---------PGPICPDSPPSPD--------PTRPPSRRKLFTFSHPVRSRDTDRFLDVLS 687
P P+ P SP +P P PPS+ S +++ T FL S
Sbjct: 328 SSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQA--THSFLP--S 383
Query: 688 EQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASDCISSSEEGSSLTYSSISD 747
L P T P ++ Q AS +S S ++++
Sbjct: 384 PPLSPLAT------PPPQAPPALALPPLQAP----PSPPASPPLSPLATPSPQAPNALAV 433
Query: 748 HIPPPPLSPPPPPPLPFHDAKPSSRS-SDGSRGPAQA---LAKPLTQL--SHPVPPP--- 798
H+ P SPPP PP+ + P+S S + P+QA LA P Q+ S P PP
Sbjct: 434 HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 493
Query: 799 ---PPPPLPPPVPCAPPMLSR 816
PPP PPP+ P L++
Sbjct: 494 SATPPPQAPPPLAAPPLQLAK 514
Score = 53.5 bits (127), Expect = 1e-06
Identities = 97/391 (24%), Positives = 130/391 (33%), Gaps = 68/391 (17%)
Query: 474 TAEPEPELDLESE-PTPEPQPRSSLRASSMCRRSLRSQGLE--AGLSCGPSECP-EMPLP 529
T P + SE T EP P + R S+ GL+ A S S P P
Sbjct: 202 TEGPRKSVSSASEHSTTEPSPAARRRPSA-------GGGLQRPASRSLSSSATPLSSPAR 254
Query: 530 LIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVT 589
P R + P P PK + A+ + +G +S S + P PS A+
Sbjct: 255 SGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQ 314
Query: 590 T-GPRTL----------------------SGVSWPSERLLPSPCYHP--LCSGGLASPSS 624
+ P TL S + PS + LPSP P + L SP+
Sbjct: 315 SQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTL 374
Query: 625 SESH---PYASLDSSRAPSPQPGPGPICP--DSPPSPDPTRPPSRRKLFTFSHPVRSRDT 679
+H P L P PQ P P +PPSP P PP L + P
Sbjct: 375 QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-PASPP----LSPLATPSPQAPN 429
Query: 680 DRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASDCISS------ 733
+ +L P P + + F V+ + S S
Sbjct: 430 ALAVHLLQAPFSP----------PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL 479
Query: 734 SEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDG-SRGPAQALAKPLTQLS 792
S +S PPP +PPP P AKP ++ + P QAL P
Sbjct: 480 QVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP 539
Query: 793 HPVPPPPPPPLP-----PPVPCAPPMLSRGL 818
P P LP P P APP+L+ L
Sbjct: 540 GQAPFSPSASLPMSPLATPPPQAPPVLAAPL 570
Score = 53.1 bits (126), Expect = 2e-06
Identities = 91/362 (25%), Positives = 133/362 (36%), Gaps = 41/362 (11%)
Query: 483 LESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDGTS 542
L S P P P ++L+ S +L + + L+C + PLPL P A S
Sbjct: 299 LSSSPLATPSPSAALQ--SQAPPTLPATPHSSSLTCQLAT----PLPLAPPSPSAPP--S 350
Query: 543 LPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPS 602
L P+P A S+ +S + S P SP T P+ ++ P
Sbjct: 351 LQTLPSPP------ATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 404
Query: 603 ERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAP-SPQPGPGPICPDSPPSPDPTRP 661
+ PSP P S LA+PS + A + +AP SP P P P SPP+ P P
Sbjct: 405 LQAPPSPPASPPLSP-LATPSPQAPNALA-VHLLQAPFSPPPSPPVQAPFSPPASPPVSP 462
Query: 662 ----PSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQG 717
PS+ + P++ + +S P P +
Sbjct: 463 SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP--PQAP 520
Query: 718 SFVTNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPP--------PPLPFHDAKP 769
+ A +S G + S S +P PL+ PPP P L + P
Sbjct: 521 PALATPPLQALPSPPASFPGQAPFSPSAS--LPMSPLATPPPQAPPVLAAPLLQVPPSPP 578
Query: 770 SSRSSDGSR-----GPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSE 824
+S + R GP +++ P L+ PPPPP P + P L+ GH S
Sbjct: 579 ASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLA---GHSSSA 635
Query: 825 TS 826
TS
Sbjct: 636 TS 637
Score = 42.7 bits (99), Expect = 0.002
Identities = 80/339 (23%), Positives = 115/339 (33%), Gaps = 61/339 (17%)
Query: 483 LESEPTPEPQPRSSLRA--SSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDG 540
L++ P+P P S A S +L L+A S PS P + P P
Sbjct: 405 LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS--PPVQAPFSPPASPPVSP 462
Query: 541 TSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSW 600
++ P + P ++A ++ +S +S S PP P + P L+
Sbjct: 463 SATPPSQAPPSLAAPPLQVPPSPPAS-----PPMSPSATPPPQAPPPLAAPPLQLAKPPP 517
Query: 601 PSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPI-------CPDSP 653
+ L +P L S + P + P ASL S +P P P+ P SP
Sbjct: 518 QAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP 577
Query: 654 PSPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFH 713
P+ + P R P DT GPR+T+ L P
Sbjct: 578 PASPTLQAPRR-------PPTPGPDT--------SVSGPRLTLA---LAP---------- 609
Query: 714 DDQGSFVTNERSSASDCISSSEEGSSLTYSSISDHI------PPPPLSPPPPPPLPFHDA 767
G RS +S G S + +S + + P + PPP
Sbjct: 610 ---GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAAC 666
Query: 768 KPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPP 806
P++ SRGP A PL P P P PP P
Sbjct: 667 HPAA----WSRGP----APPLAFRGAPGAPLPWPPATGP 697
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 62.8 bits (151), Expect = 2e-09
Identities = 96/351 (27%), Positives = 132/351 (37%), Gaps = 50/351 (14%)
Query: 485 SEPTP-EPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEM-PLPLIPGERQAGDGTS 542
S PTP P P +M RRS R+ G E GL P P P P G R++ S
Sbjct: 156 SGPTPGTPSP-------AMARRS-RAAGTEVGL---PRPAPSARPRPPTEGPRKSVSSAS 204
Query: 543 LPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPS 602
T P + L + + + +SP P+ PR + S P
Sbjct: 205 EHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPK 264
Query: 603 ERLLPSPCYHPLCSGGLASPSSSESHPYASLDSS--RAPSPQPGPGPICPDSP---PSPD 657
+ L + L + P + L SS PSP P P P S PSP
Sbjct: 265 PKGLQA-----LRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSP- 318
Query: 658 PTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQG 717
P PPS+ S +++ T FL S L P T P ++ Q
Sbjct: 319 PATPPSQATTSLGSPTLQA--THSFLP--SPPLSPLAT------PPPQAPPALALPPLQA 368
Query: 718 SFVTNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRS-SDG 776
AS +S S ++++ H+ P SPPP PP+ + P+S S
Sbjct: 369 P----PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS 424
Query: 777 SRGPAQA---LAKPLTQL--SHPVPPP------PPPPLPPPVPCAPPMLSR 816
+ P+QA LA P Q+ S P PP PPP PPP+ P L++
Sbjct: 425 ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAK 475
Score = 57.4 bits (137), Expect = 8e-08
Identities = 94/369 (25%), Positives = 125/369 (33%), Gaps = 54/369 (14%)
Query: 474 TAEPEPELDLESE-PTPEPQPRSSLRASSMCRRSLRSQGLE--AGLSCGPSECP-EMPLP 529
T P + SE T EP P + R S+ GL+ A S S P P
Sbjct: 193 TEGPRKSVSSASEHSTTEPSPAARRRPSA-------GGGLQRPASRSLSSSATPLSSPAR 245
Query: 530 LIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPS-PAV 588
P R + P P PK + A+ + +G +S S + P PS P
Sbjct: 246 SGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPS 305
Query: 589 TTGPRTLSGVSWPSERLLPSPCYHP--LCSGGLASPSSSESH---PYASLDSSRAPSPQP 643
+ P PS + LPSP P + L SP+ +H P L P PQ
Sbjct: 306 PSAP--------PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 357
Query: 644 GPGPICP--DSPPSPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFL 701
P P +PPSP P PP L + P + +L P
Sbjct: 358 PPALALPPLQAPPSP-PASPP----LSPLATPSPQAPNALAVHLLQAPFSP--------- 403
Query: 702 TPENDYEEMSFHDDQGSFVTNERSSASDCISS------SEEGSSLTYSSISDHIPPPPLS 755
P + + F V+ + S S S +S PPP +
Sbjct: 404 -PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA 462
Query: 756 PPPPPPLPFHDAKPSSRSSDG-SRGPAQALAKPLTQLSHPVPPPPPPPLP-----PPVPC 809
PPP P AKP ++ + P QAL P P P LP P P
Sbjct: 463 PPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 522
Query: 810 APPMLSRGL 818
APP+L+ L
Sbjct: 523 APPVLAAPL 531
Score = 45.8 bits (107), Expect = 2e-04
Identities = 85/356 (23%), Positives = 124/356 (34%), Gaps = 38/356 (10%)
Query: 489 PEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDGTSLPETPN 548
P+P+ +LR + + LS P P P P SL P+
Sbjct: 263 PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPP-----SLQTLPS 317
Query: 549 PKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPS 608
P A S+ +S + S P SP T P+ ++ P + PS
Sbjct: 318 PP------ATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPS 371
Query: 609 PCYHPLCSGGLASPSSSESHPYASLDSSRAP-SPQPGPGPICPDSPPSPDPTRP----PS 663
P P S LA+PS + A + +AP SP P P P SPP+ P P PS
Sbjct: 372 PPASPPLSP-LATPSPQAPNALA-VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPS 429
Query: 664 RRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVTNE 723
+ + P++ + +S P P + +
Sbjct: 430 QAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP--PQAPPALATP 487
Query: 724 RSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPP--------PPLPFHDAKPSSRSSD 775
A +S G + S S +P PL+ PPP P L + P+S +
Sbjct: 488 PLQALPSPPASFPGQAPFSPSAS--LPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 545
Query: 776 GSR-----GPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETS 826
R GP +++ P L+ PPPPP P + P L+ GH S TS
Sbjct: 546 APRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLA---GHSSSATS 598
Score = 42.7 bits (99), Expect = 0.002
Identities = 80/339 (23%), Positives = 115/339 (33%), Gaps = 61/339 (17%)
Query: 483 LESEPTPEPQPRSSLRA--SSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDG 540
L++ P+P P S A S +L L+A S PS P + P P
Sbjct: 366 LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS--PPVQAPFSPPASPPVSP 423
Query: 541 TSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSW 600
++ P + P ++A ++ +S +S S PP P + P L+
Sbjct: 424 SATPPSQAPPSLAAPPLQVPPSPPAS-----PPMSPSATPPPQAPPPLAAPPLQLAKPPP 478
Query: 601 PSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPI-------CPDSP 653
+ L +P L S + P + P ASL S +P P P+ P SP
Sbjct: 479 QAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP 538
Query: 654 PSPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFH 713
P+ + P R P DT GPR+T+ L P
Sbjct: 539 PASPTLQAPRR-------PPTPGPDT--------SVSGPRLTLA---LAP---------- 570
Query: 714 DDQGSFVTNERSSASDCISSSEEGSSLTYSSISDHI------PPPPLSPPPPPPLPFHDA 767
G RS +S G S + +S + + P + PPP
Sbjct: 571 ---GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAAC 627
Query: 768 KPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPP 806
P++ SRGP A PL P P P PP P
Sbjct: 628 HPAA----WSRGP----APPLAFRGAPGAPLPWPPATGP 658
>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
sapiens]
Length = 483
Score = 60.8 bits (146), Expect = 7e-09
Identities = 33/72 (45%), Positives = 38/72 (52%), Gaps = 16/72 (22%)
Query: 750 PPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPV-----------PPP 798
PPPP PPPPPPLP P SS + P + PLT+ + PV PPP
Sbjct: 174 PPPPTPPPPPPPLP-----PPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPP 228
Query: 799 PPPPLPPPVPCA 810
PPPP PPP+P A
Sbjct: 229 PPPPTPPPLPPA 240
Score = 53.9 bits (128), Expect = 9e-07
Identities = 60/236 (25%), Positives = 86/236 (36%), Gaps = 61/236 (25%)
Query: 639 PSPQPGPGPICPDSPP-SPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSE-QLGPR--- 693
P P P P P+ P PP P PPS + T + +R D +L++ Q G R
Sbjct: 2 PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61
Query: 694 VTIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASDC------------------ISSSE 735
VT ++D P+ + + + + GS T S+ ++ +
Sbjct: 62 VTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGK 121
Query: 736 EGSS---------LTYSSISDHIPPP------------------------PLSPPPPPPL 762
G L +IS + PP P PPP PP
Sbjct: 122 TGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPP 181
Query: 763 PFHDAKPSSRSSDGSRGPAQALAKPLTQ-----LSHPVPPPPPPPLPPPVPCAPPM 813
P P SS + P + PLT+ ++ PVP PPPP PPP P PP+
Sbjct: 182 PPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPL 237
Score = 42.7 bits (99), Expect = 0.002
Identities = 33/98 (33%), Positives = 41/98 (41%), Gaps = 26/98 (26%)
Query: 740 LTYSSISDHIPPPPLSPPPPPPLP---FHDAKPSSRSSDGSRGPAQA------LAKPLTQ 790
LT ++ PP P +PPPPPP P P+S SD + P A + PL
Sbjct: 207 LTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPL 266
Query: 791 L---------SHPV--------PPPPPPPLPPPVPCAP 811
L + P PP PPPPLPP C+P
Sbjct: 267 LPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSP 304
Score = 37.7 bits (86), Expect = 0.067
Identities = 51/199 (25%), Positives = 68/199 (34%), Gaps = 27/199 (13%)
Query: 469 GYTAMTAEPEPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPL 528
G + A P P P P P P AS + ++++ Q L P P +P
Sbjct: 210 GNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPP 269
Query: 529 PLIPG--ERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGP-- 584
PG A E P P YA R + G S S PP P
Sbjct: 270 CGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPK 329
Query: 585 SPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPG 644
SP+ P+ + LP+P P+ S P+ L R P G
Sbjct: 330 SPSFQAPPQKAGA------QALPAP------------PAPPGSQPF--LQKKRHGRPGAG 369
Query: 645 PGPICPDSPPSPDPTRPPS 663
G + P PP+P P R P+
Sbjct: 370 GGKLNP--PPAP-PARSPT 385
Score = 37.0 bits (84), Expect = 0.11
Identities = 26/76 (34%), Positives = 31/76 (40%), Gaps = 11/76 (14%)
Query: 748 HIPP--PPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPL-- 803
H+PP PPL PP P A+P+S + D PA P P P PPL
Sbjct: 256 HLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPG 315
Query: 804 -------PPPVPCAPP 812
PPP+P P
Sbjct: 316 VNSSSETPPPLPPKSP 331
Score = 33.5 bits (75), Expect = 1.3
Identities = 70/276 (25%), Positives = 83/276 (30%), Gaps = 55/276 (19%)
Query: 538 GDGTSLPETPNPKMMSAVYAELESRL-NSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLS 596
G P PN + + RL N+S + R + P P P P
Sbjct: 127 GSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPL 186
Query: 597 GVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSP 656
PS SP PL S P L P P P P P PP P
Sbjct: 187 PPPLPSS----SPIKTPLVS------------PPGPLTKGNLPVVAP-PVPCAPPPPPPP 229
Query: 657 DPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQ 716
P PP P S +D+ + QL P L P +
Sbjct: 230 PPPTPPPL--------PPASVLSDK---AVKPQLAPL------HLPPIPPPLPLLPPCGY 272
Query: 717 GSFVTNERSSASDCISSSEEGSSL-TYSSISDH--IPPPPL-----SPPPPPPLPFHDAK 768
S A D L Y+S S +P PPL S PPPLP K
Sbjct: 273 PGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLP---PK 329
Query: 769 PSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLP 804
S + + AQAL P PP PP P
Sbjct: 330 SPSFQAPPQKAGAQAL---------PAPPAPPGSQP 356
Score = 32.7 bits (73), Expect = 2.1
Identities = 54/205 (26%), Positives = 70/205 (34%), Gaps = 47/205 (22%)
Query: 472 AMTAEPEPELDLESEPTPEPQP---RSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPL 528
A TA P P + PTP P P L +SS + L S L+ G P+
Sbjct: 162 ARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSP--PGPLTKGNLPVVAPPV 219
Query: 529 PLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAV 588
P P P TP P ++V ++ + K ++ + PP P
Sbjct: 220 PCAPPPPPPPP----PPTPPPLPPASVLSD------KAVKPQLAPLHLPPIPPPLP---- 265
Query: 589 TTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESH---------PYASLDSSRAP 639
LLP PC +P ASP+ PYAS S RA
Sbjct: 266 ----------------LLP-PCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASC-SPRAS 307
Query: 640 SPQPG-PGPICPDSPPSPDPTRPPS 663
P P PG P P P + PS
Sbjct: 308 LPAPPLPGVNSSSETPPPLPPKSPS 332
>gi|150418009 transforming, acidic coiled-coil containing protein 2
isoform a [Homo sapiens]
Length = 2948
Score = 60.8 bits (146), Expect = 7e-09
Identities = 97/394 (24%), Positives = 143/394 (36%), Gaps = 79/394 (20%)
Query: 474 TAEPEPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPG 533
T P P+ ++ + P +P + R + + LE + G P P
Sbjct: 1631 TCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPP------ 1684
Query: 534 ERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPR 593
G+ P P +A AE + L+++ +++A G P T R
Sbjct: 1685 ---TGEVADTPLEPGKVAGAAGEAEGDITLSTA---------ETQACASGDLPEAGT-TR 1731
Query: 594 TLSGVSWPSERLLPSPCYHPLCS-------GGLASPSSSESHPYASLDSSRAPSPQP-GP 645
T S V+ + +LP C P CS G A S + P + + P P G
Sbjct: 1732 TFSVVA--GDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGD 1789
Query: 646 GPICPDSPPSPDPTRPPSRRKLF---------------TFSHPVRSRDTDRFLDVLS--E 688
G +C SPP PD T P + L + V +D R +D ++ E
Sbjct: 1790 GKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDE 1849
Query: 689 QLGPRVT----IVDDFLTP--ENDYEE-----MSFHDDQGSFVTNERSSASDCISSSEEG 737
G T + DD + P D E S+H D V+ + + S +++ G
Sbjct: 1850 TRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAG 1909
Query: 738 SSLTYSSISDHIPPPPL---------SPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPL 788
S ++HI P +P P P AK SRSSD A +
Sbjct: 1910 LP---PSAAEHIVSPSAPAGDRVEASTPSCPDP-----AKDLSRSSDSEE--AFETPEST 1959
Query: 789 TQLSHPVPPPPPPP--LP-PPVPCAPPMLSRGLG 819
T + P PPPPPP +P P V PP G G
Sbjct: 1960 TPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCG 1993
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 60.1 bits (144), Expect = 1e-08
Identities = 87/362 (24%), Positives = 122/362 (33%), Gaps = 83/362 (22%)
Query: 460 CQEKIACFLGYTAMTAEPE--PELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLS 517
C+ ++ C L + P P L + Q SL SS C +L ++
Sbjct: 575 CRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEAL--------VT 626
Query: 518 CGPSECPEMPLPLIPGERQAGDGTSLP--ETPNPKMMSAVYAELESRLNSSFKGKMGTVS 575
C P +P PL P +P E P+P +
Sbjct: 627 CAALTHPRVP-PLQPMGPTCPTPAPVPPPEAPSPFRAPPFH------------------- 666
Query: 576 KSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDS 635
PPGP P+V + P S PS +PS P G P ++ +H S+
Sbjct: 667 -----PPGPMPSVGSMP---SAGPMPSAGPMPSAGPVPSARPG---PPTTANHLGLSVPG 715
Query: 636 SRAPSPQPGPGPICPDSPPSPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVT 695
+ P+ PGP + + DP PS P T
Sbjct: 716 LVSVPPRLLPGPENHRAGSNEDPILAPSGT--------------------------PPPT 749
Query: 696 IVDDFLTPENDYEEMSFHDDQGSFVTNERSSASDCISSSEEGSSLTYSSISDHIPPPPLS 755
I D E + +FV ++ ASD S E S + + + +PP P
Sbjct: 750 IPPD--------ETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPP 801
Query: 756 PPP---PPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPP 812
PP PPP+ +S P + A P P PPPPPPP+P PV PP
Sbjct: 802 PPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPL---PPPPPPPPPVPGPVTLPPP 858
Query: 813 ML 814
L
Sbjct: 859 QL 860
Score = 43.1 bits (100), Expect = 0.002
Identities = 73/338 (21%), Positives = 100/338 (29%), Gaps = 69/338 (20%)
Query: 527 PLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPS- 585
P P IP + G P + A E+ +S + PP PS
Sbjct: 746 PPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSG 805
Query: 586 ----PAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSP 641
P TGP T S P P P G L P P P
Sbjct: 806 ATPPPIAPTGPPTAS----PPVPAKEEPEELPAAPGPLPPPP---------------PPP 846
Query: 642 QPGPGPICPDSPP-----SPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTI 696
P PGP+ P +P PP+ + T + S + + + E+
Sbjct: 847 PPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEE 906
Query: 697 VDDFLTPENDYEEM-------------SFHDDQGSFVTNERSSASDCISSSEEGSSLTYS 743
+DF E D EE F +++G E + EE L +
Sbjct: 907 EEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFG 966
Query: 744 S----ISDHIPPPPLSPP--PPPPLP--------------FHDAKPSSRSSDGSRGPAQA 783
+ + + PPPP PP PPP P +P + G+
Sbjct: 967 TAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTL 1026
Query: 784 LAKPLTQLSH-------PVPPPPPPPLPPPVPCAPPML 814
+ L P PPP L P APP L
Sbjct: 1027 APEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTL 1064
>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
Length = 3571
Score = 59.7 bits (143), Expect = 2e-08
Identities = 32/68 (47%), Positives = 34/68 (50%), Gaps = 6/68 (8%)
Query: 745 ISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLP 804
IS P P PPPPPPLP +PSS GP + T L P P PPPPP P
Sbjct: 1950 ISPSSPETPPPPPPPPPLPPAPPQPSSM------GPVKIPNTVSTPLQAPPPTPPPPPPP 2003
Query: 805 PPVPCAPP 812
PP P PP
Sbjct: 2004 PPPPPPPP 2011
Score = 57.8 bits (138), Expect = 6e-08
Identities = 34/73 (46%), Positives = 38/73 (52%), Gaps = 13/73 (17%)
Query: 743 SSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQ---ALAKPLTQLSHPVPPPP 799
S S PPPP PPP PP P +PS S GP + ++ PL Q P PPPP
Sbjct: 1951 SPSSPETPPPPPPPPPLPPAP---PQPS------SMGPVKIPNTVSTPL-QAPPPTPPPP 2000
Query: 800 PPPLPPPVPCAPP 812
PPP PPP P PP
Sbjct: 2001 PPPPPPPPPPPPP 2013
Score = 43.1 bits (100), Expect = 0.002
Identities = 25/77 (32%), Positives = 30/77 (38%), Gaps = 29/77 (37%)
Query: 738 SSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPP 797
SS+ I + + P +PPP PP P P PP
Sbjct: 1975 SSMGPVKIPNTVSTPLQAPPPTPPPP-----------------------------PPPPP 2005
Query: 798 PPPPPLPPPVPCAPPML 814
PPPPP PPP P APP +
Sbjct: 2006 PPPPPPPPPPPSAPPQV 2022
Score = 40.8 bits (94), Expect = 0.008
Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 5/86 (5%)
Query: 754 LSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPM 813
L+PP L F P+S +S + + A KPL Q P PPPPPPP P
Sbjct: 3083 LTPPGAGMLGF----PTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPP-PSSSLSGQQT 3137
Query: 814 LSRGLGHRRSETSHMSVKRLRWEQVE 839
+ + +T VK+++ E++E
Sbjct: 3138 EQQNKESEKKQTKPNKVKKIKEEELE 3163
Score = 36.2 bits (82), Expect = 0.19
Identities = 16/29 (55%), Positives = 19/29 (65%), Gaps = 2/29 (6%)
Query: 787 PLTQLSHPVPPPPPPPLPPPVPCAPPMLS 815
P++ S PPPPPP PPP+P APP S
Sbjct: 1949 PISPSSPETPPPPPP--PPPLPPAPPQPS 1975
Score = 33.5 bits (75), Expect = 1.3
Identities = 32/110 (29%), Positives = 41/110 (37%), Gaps = 24/110 (21%)
Query: 556 YAELE--SRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHP 613
YA LE +R K+ +S S P P P P L P+P P
Sbjct: 1930 YAALEKFARQYREAYDKLYPISPSSPETPPPPP--------------PPPPLPPAPP-QP 1974
Query: 614 LCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPS 663
G + P++ + +AP P P P P P PP P P PPS
Sbjct: 1975 SSMGPVKIPNTVST-------PLQAPPPTPPPPPPPPPPPPPPPPPPPPS 2017
Score = 33.5 bits (75), Expect = 1.3
Identities = 37/148 (25%), Positives = 54/148 (36%), Gaps = 15/148 (10%)
Query: 681 RFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSF----VTNERSSASDCISSSEE 736
R D+++ Q DD E+ E+ DQ + V+ + +A + + +
Sbjct: 2278 RIFDLITHQKKQCYKDEDDDAQDESQTEDSMDATDQVVYKHCTVSGQTDAAKNAAAPAAS 2337
Query: 737 GSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVP 796
S T + + P P P P P K S S S+G AL PL S P
Sbjct: 2338 SGSGTSTPLIPSPKPEPEKTSPKPEYPAEKPKQSDPSPP-SQGTKPAL--PLASTSSDPP 2394
Query: 797 --------PPPPPPLPPPVPCAPPMLSR 816
P P PP P + PP S+
Sbjct: 2395 QASTAQPQPQPQPPKQPQLIGRPPSASQ 2422
Score = 32.7 bits (73), Expect = 2.1
Identities = 29/89 (32%), Positives = 36/89 (40%), Gaps = 16/89 (17%)
Query: 582 PGPSPAVT---TGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRA 638
PG P + GP +L G S L P +G L P+S+ S P SL S A
Sbjct: 3057 PGLPPVLLPGMNGPSSLPGFPQNSNTLTPPG------AGMLGFPTSATSSPALSLSS--A 3108
Query: 639 PSPQPGPGPICPDSPPSPDPTRPPSRRKL 667
P+ P+ PP P P PP L
Sbjct: 3109 PTK-----PLLQTPPPPPPPPPPPPSSSL 3132
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
1 [Homo sapiens]
Length = 1522
Score = 58.5 bits (140), Expect = 4e-08
Identities = 73/278 (26%), Positives = 111/278 (39%), Gaps = 46/278 (16%)
Query: 274 GGARRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAALKSGDRILFLNGLDMRNCS 333
G +R V + K FGFT+ G V ++SV PG A A +K GDRI+ +NG + N S
Sbjct: 42 GLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSS 101
Query: 334 HDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDSPNPSSALTSLQWVAEILPSSIRVQG 393
H +VV +++ SGA L + S P+P+ A + ++P
Sbjct: 102 HLEVVKLIK-SGAYVALTLLGSSPSSMGISGLQQDPSPAGA----PRITSVIP------- 149
Query: 394 RTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLT 453
S L PP+R I P+ D ++ Q + +L
Sbjct: 150 ---SPPPPPPLPPPQR-------------------ITGPKPLQDPEVQKHATQILRNMLR 187
Query: 454 YEEQELCQEKIACFLGYTAMTAEPEPELDLESEPTPE-----PQPRSSLRASSMCRRSLR 508
EE+EL + I G T+ E L L+S+ + SL S M R S+
Sbjct: 188 QEEKEL--QDILPLYGDTSQRPS-EGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVL 244
Query: 509 SQGLEAGLSCGPSECPEMPLPLIPGERQAGDGTSLPET 546
S + GL P P + + R+ G ++P T
Sbjct: 245 S---DPGLD-SPRTSPVIMARVAQHHRRQGSDAAVPST 278
Score = 37.7 bits (86), Expect = 0.067
Identities = 26/86 (30%), Positives = 39/86 (45%), Gaps = 13/86 (15%)
Query: 17 FGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRERLVRLARRCPRV- 75
FGF + G V V G +A G++ GD+I++V G V S +V+L + V
Sbjct: 57 FGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVA 116
Query: 76 -------PPSLGVL-----PAPDGGP 89
P S+G+ P+P G P
Sbjct: 117 LTLLGSSPSSMGISGLQQDPSPAGAP 142
Score = 33.1 bits (74), Expect = 1.6
Identities = 19/42 (45%), Positives = 25/42 (59%), Gaps = 5/42 (11%)
Query: 767 AKPSSRSSDG-SRGPAQALAKPLTQLSHPVP-PPPPPPLPPP 806
+ PSS G + P+ A A +T + +P PPPPPPLPPP
Sbjct: 122 SSPSSMGISGLQQDPSPAGAPRITSV---IPSPPPPPPLPPP 160
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,134,626
Number of Sequences: 37866
Number of extensions: 3559061
Number of successful extensions: 64151
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 574
Number of HSP's successfully gapped in prelim test: 1216
Number of HSP's that attempted gapping in prelim test: 29148
Number of HSP's gapped (non-prelim): 20664
length of query: 1211
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1097
effective length of database: 13,930,794
effective search space: 15282081018
effective search space used: 15282081018
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.