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Search of human proteins with 223278356
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223278356 glutamate receptor, ionotropic,
N-methyl-D-aspartate 3A [Homo sapiens]
(1115 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 2270 0.0
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 951 0.0
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 303 6e-82
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 299 1e-80
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 299 1e-80
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 299 1e-80
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 277 5e-74
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 276 6e-74
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 252 2e-66
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 252 2e-66
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 252 2e-66
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 162 2e-39
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 162 2e-39
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 159 2e-38
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 158 2e-38
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 158 2e-38
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 157 5e-38
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 157 7e-38
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 155 3e-37
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 154 6e-37
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 153 8e-37
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 153 8e-37
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 149 1e-35
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 149 1e-35
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 149 2e-35
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 147 7e-35
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 146 1e-34
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 145 2e-34
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 135 2e-31
gi|68989256 ras inhibitor RIN1 [Homo sapiens] 44 0.001
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
[Homo sapiens]
Length = 1115
Score = 2270 bits (5883), Expect = 0.0
Identities = 1115/1115 (100%), Positives = 1115/1115 (100%)
Query: 1 MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTT 60
MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTT
Sbjct: 1 MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTT 60
Query: 61 APRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAE 120
APRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAE
Sbjct: 61 APRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAE 120
Query: 121 ALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSF 180
ALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSF
Sbjct: 121 ALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSF 180
Query: 181 LQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQL 240
LQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQL
Sbjct: 181 LQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQL 240
Query: 241 SLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITAN 300
SLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITAN
Sbjct: 241 SLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITAN 300
Query: 301 LPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQ 360
LPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQ
Sbjct: 301 LPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQ 360
Query: 361 NVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCM 420
NVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCM
Sbjct: 361 NVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCM 420
Query: 421 EVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTR 480
EVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTR
Sbjct: 421 EVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTR 480
Query: 481 LGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAG 540
LGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAG
Sbjct: 481 LGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAG 540
Query: 541 QLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIV 600
QLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIV
Sbjct: 541 QLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIV 600
Query: 601 GDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTR 660
GDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTR
Sbjct: 601 GDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTR 660
Query: 661 DTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSAL 720
DTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSAL
Sbjct: 661 DTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSAL 720
Query: 721 NICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGI 780
NICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGI
Sbjct: 721 NICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGI 780
Query: 781 HDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLD 840
HDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLD
Sbjct: 781 HDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLD 840
Query: 841 AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFM 900
AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFM
Sbjct: 841 AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFM 900
Query: 901 DMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLL 960
DMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLL
Sbjct: 901 DMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLL 960
Query: 961 PRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLS 1020
PRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLS
Sbjct: 961 PRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLS 1020
Query: 1021 HDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELS 1080
HDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELS
Sbjct: 1021 HDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELS 1080
Query: 1081 ELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES 1115
ELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES
Sbjct: 1081 ELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES 1115
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 951 bits (2457), Expect = 0.0
Identities = 509/1047 (48%), Positives = 681/1047 (65%), Gaps = 83/1047 (7%)
Query: 95 ARWLGSTLH-GRGPPGSR--------KPGEGARAEALWPRDALLFAVDNLNRVEGLL--- 142
A WLG L G G G + G R AL PR L A L
Sbjct: 6 ALWLGLALALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARAALAPR 65
Query: 143 -PYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQ 201
P+NLSLE+V+A +P + DP S + +C +V GV+ALLAFP+
Sbjct: 66 LPHNLSLELVVA-----------------APPARDPASLTRGLCQALVPPGVAALLAFPE 108
Query: 202 SQGEMMELDLVSLVLHIPVISIVRHE--FPRESQNPLHLQLSLENSLSSDADVTVSILTM 259
++ E+++L ++ PV+S++R E P + NP HLQL + L + DV V++L
Sbjct: 109 ARPELLQLHFLAAATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQA 168
Query: 260 NNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESI- 318
+ W + L LC+ + + L + + +++++ L + L +
Sbjct: 169 HAWEDVGLALCRTQ-DPGGLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVG 227
Query: 319 -KNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAH 377
+ P V+ GCD+ RR+ E +PP W+LG + L T GLP GL+A
Sbjct: 228 GEAPVPAAVLLGCDIARARRVLE------AVPPGPHWLLGTPLPPKALPTAGLPPGLLAL 281
Query: 378 GKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTS-GQYLSRF 436
G+ + E + D ++LVARA+ +A +QP+ AL+P+ +NC +++ S G++L+RF
Sbjct: 282 GEVARPPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARF 341
Query: 437 LANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYG-- 494
LANT+F+G +G + V GS+ V +F +W+L+ DP G P W +GSW+ G++ ++ G
Sbjct: 342 LANTSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGA 401
Query: 495 -----------IWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLC 543
+WP+ LRVVTL+EHPFVF R+ D++G CPAGQLC
Sbjct: 402 SARPPPPQGAQVWPK----------------LRVVTLLEHPFVFARDPDEDGQCPAGQLC 445
Query: 544 LDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDG 603
LDP TNDS+TLD+LF++L +N + P +KCCYGYCIDLLE++AED FDF+LY+VGDG
Sbjct: 446 LDPGTNDSATLDALFAAL--ANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDG 503
Query: 604 KYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTA 663
KYGA ++G WTGLVGDLL G AHMAVTSFSIN+ARSQV+DFTSPFFSTSLGI+VR RDTA
Sbjct: 504 KYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTA 563
Query: 664 APIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNIC 723
+PIGAFMWPLHW+ WLG+F ALH+TA+FLT+YEW+SP+GLTP+GRNRS VFS+SSALN+C
Sbjct: 564 SPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLC 623
Query: 724 YALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDP 783
YA+LF RTV+ K PKC TGR LMNLWAIFC+ LS+YTANLAAVMVG+K +EELSGIHDP
Sbjct: 624 YAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDP 683
Query: 784 KLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFI 843
KLHHP+QGFRFGTV ESSAE Y+++SFP+MH +MRR++ P TP GV L +DP KL+AFI
Sbjct: 684 KLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFI 743
Query: 844 MDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDML 903
MDK+LLDYEVSIDADCKLLTVGKPFAIEGYGIGLP NSPLT+N+SE IS+YKS GF+D+L
Sbjct: 744 MDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLL 803
Query: 904 HDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRI 963
HDKWY++VPCGKR FAVTETLQM I HF+GLFVLLC+G G ++L+++GEH +RL LPRI
Sbjct: 804 HDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRI 863
Query: 964 KNKSKLQYWLHTSQRLHRAINTSFIE-------EKQQHFKTKRVEKRSNVGPRQLTVWNT 1016
+ S+LQYWLHTSQ++HRA+NT E E + +++ P W
Sbjct: 864 RKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKR 923
Query: 1017 SNLSHDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVM 1076
+ + D R+ F E + + D RE P + G+ + +
Sbjct: 924 ARRAVDKERRVRFLLEPA---VVVAPEADAEAEAAPREGPVWLCSYGRPPAARPTGAPQP 980
Query: 1077 QELSELEKQIQVIRQELQLAVSRKTEL 1103
EL ELE++I+V R+ L+ A+ R+ +L
Sbjct: 981 GELQELERRIEVARERLRQALVRRGQL 1007
Score = 38.1 bits (87), Expect = 0.047
Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 2/42 (4%)
Query: 27 GVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRA 68
G S+ HPQPC +L R+G +VR+GA L P RA +RA
Sbjct: 16 GPGSAGGHPQPCGVLARLGGSVRLGA--LLPRAPLARARARA 55
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor [Homo
sapiens]
Length = 1484
Score = 303 bits (776), Expect = 6e-82
Identities = 248/885 (28%), Positives = 416/885 (47%), Gaps = 81/885 (9%)
Query: 175 SDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMME--LDLVSLVLHIPVISIVRHE---FP 229
+DP S + +C + + + ++ + E + LD +S P++ I
Sbjct: 76 TDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMA 135
Query: 230 RESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDW--NITDFLLLTQNNS 287
+ ++ + Q S+ A V ++I+ +WY FS++ + + + T NS
Sbjct: 136 DKDESSMFFQFG--PSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENS 193
Query: 288 --KFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQF 345
+ L ++ + +L D S +Q QL+ +++ +++ C E IFE+
Sbjct: 194 FVGWELEEVLLLDMSL---DDGDSKIQNQLKKLQSP---IILLYCTKEEATYIFEVANSV 247
Query: 346 GVMPPELRWVL-----GDSQNVEELRTEGLPLGLIAHGKTTQSV-FEHYVQDAMELVARA 399
G+ W++ GD+ V P GLI+ V+D + ++ A
Sbjct: 248 GLTGYGYTWIVPSLVAGDTDTVPA----EFPTGLISVSYDEWDYGLPARVRDGIAIITTA 303
Query: 400 VATATMIQPELALIPSTMN-CMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVS 458
A+ + E + IP + C + L+R+L N TF G + S G +
Sbjct: 304 ---ASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQM-H 359
Query: 459 SENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVV 518
+ + N + W R+G W+ + M Y +WP +T Q HL +V
Sbjct: 360 PKLVIILLNKERK------WERVGKWKDKSLQMKYYVWPRMCP--ETEEQEDD--HLSIV 409
Query: 519 TLIEHPFVFTREVDD-EGLCPAGQL-CLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCC 576
TL E PFV VD G C + C + ++ T D P KKCC
Sbjct: 410 TLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKT------------DEEPGYIKKCC 457
Query: 577 YGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINT 636
G+CID+L+KI++ + F +DLY+V +GK+G NG W G++G+++ A+MAV S +IN
Sbjct: 458 KGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINE 517
Query: 637 ARSQVIDFTSPFFSTSLGILV-RTRDTAAPIGAFMWPLHWTMWLGIFVALHI-TAVFLTL 694
RS+V+DF+ PF T + ++V R+ T +P AF+ P +W+ +FV L I +AV + +
Sbjct: 518 ERSEVVDFSVPFIETGISVMVSRSNGTVSP-SAFLEPFSADVWVMMFVMLLIVSAVAVFV 576
Query: 695 YEWKSPFG----LTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWA 750
+E+ SP G L F+ A+ + + L+F +V ++ PK T + ++++WA
Sbjct: 577 FEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 636
Query: 751 IFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHP---SQGFRFGTVRESSAEDYVR 807
F + L++YTANLAA M+ E+ +++SG+ D K P S FRFGTV S E +R
Sbjct: 637 FFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIR 696
Query: 808 QSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTV--G 865
++ EMH YM ++N D + LK KLDAFI D A+L+Y D CKL+T+ G
Sbjct: 697 NNYAEMHAYMGKFNQRGVDDALLSLKTG--KLDAFIYDAAVLNYMAGRDEGCKLVTIGSG 754
Query: 866 KPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQ 925
K FA GYGI + +S + I Q G M+ L W + +++ ++ Q
Sbjct: 755 KVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSS--Q 812
Query: 926 MGIKHFSGLFVLLCIGFGLSILTTIGEHIVY----RLLLPRIKNKSKLQYWLHTSQRLHR 981
+ I + +G+F +L LS++T I EH+ Y + K + + + S+ ++
Sbjct: 813 LDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSI--SRGIYS 870
Query: 982 AINTSFIEEKQQHFKTKRV---EKRSNVGPRQLTVWNTSNLSHDN 1023
I+ IEE+Q + SN+ T N +NLS N
Sbjct: 871 CIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVN 915
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 299 bits (765), Expect = 1e-80
Identities = 241/873 (27%), Positives = 421/873 (48%), Gaps = 62/873 (7%)
Query: 175 SDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMME--LDLVSLVLHIPVISIVRH-EFPRE 231
+DP S + VC + + L+ + E + LD +S +P++ I
Sbjct: 77 TDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMA 136
Query: 232 SQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLL--LCQEDWNITDFLLLTQNNSKF 289
++P S+ A V + I+ +W+ FSL+ + F+ T +NS F
Sbjct: 137 DKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNS-F 195
Query: 290 HLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMP 349
+ N+ S +D + Q+QL+ I +S V++ C + I G+
Sbjct: 196 VGWDMQNVITLDTSFEDAKT--QVQLKKIHSS---VILLYCSKDEAVLILSEARSLGLTG 250
Query: 350 PELRWVLGD--SQNVEELRTEGLPLGLIAHGKTTQSV-FEHYVQDAMELVARAVATATMI 406
+ W++ S N E + E P GLI+ E V+D + ++ A ++M+
Sbjct: 251 YDFFWIVPSLVSGNTELIPKE-FPSGLISVSYDDWDYSLEARVRDGIGILT--TAASSML 307
Query: 407 QPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIW 466
+ + + +C L F+ N T+ G S +G + +
Sbjct: 308 EKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQV---HPRLVVI 364
Query: 467 NLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQ-HPSKLHLRVVTLIEHPF 525
L D W ++G W+ + + + +WP R+K+ P HL +VTL E PF
Sbjct: 365 VLNKDRE----WEKVGKWENHTLSLRHAVWP----RYKSFSDCEPDDNHLSIVTLEEAPF 416
Query: 526 VFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLE 585
V ++D P + C+ ++ +S+N+ + +K KCC G+CID+L+
Sbjct: 417 VIVEDID-----PLTETCV----RNTVPCRKFVKINNSTNEGMNVK--KCCKGFCIDILK 465
Query: 586 KIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFT 645
K++ + F +DLY+V +GK+G N W G++G+++ A MAV S +IN RS+V+DF+
Sbjct: 466 KLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFS 525
Query: 646 SPFFSTSLGILV-RTRDTAAPIGAFMWPLHWTMWLGIFVALHI-TAVFLTLYEWKSPFGL 703
PF T + ++V R+ T +P AF+ P ++W+ +FV L I +A+ + ++E+ SP G
Sbjct: 526 VPFVETGISVMVSRSNGTVSP-SAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGY 584
Query: 704 T---PKGR-NRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLST 759
KG+ F+ A+ + + L+F +V ++ PK T + ++++WA F + L++
Sbjct: 585 NRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLAS 644
Query: 760 YTANLAAVMVGEKIYEELSGIHDPKLHHP---SQGFRFGTVRESSAEDYVRQSFPEMHEY 816
YTANLAA M+ E+ ++++G+ D K P S FRFGTV S E +R ++P MH+Y
Sbjct: 645 YTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQY 704
Query: 817 MRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKP--FAIEGYG 874
M ++N D + LK KLDAFI D A+L+Y+ D CKL+T+G FA GYG
Sbjct: 705 MTKFNQKGVEDALVSLKTG--KLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYG 762
Query: 875 IGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGL 934
I L SP I + Q+ G M+ L W + +++ ++ Q+ I + +G+
Sbjct: 763 IALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSS--QLDIDNMAGV 820
Query: 935 FVLLCIGFGLSILTTIGEHIVY---RLLLPRI-KNKSKLQYWLHTSQRLHRAINTSFIEE 990
F +L LS++T I EH+ Y R + ++ L + + S+ ++ I+ IEE
Sbjct: 821 FYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSI--SRGIYSCIHGVHIEE 878
Query: 991 KQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDN 1023
K++ +SN+ + N S++S+ N
Sbjct: 879 KKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMN 911
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 299 bits (765), Expect = 1e-80
Identities = 241/873 (27%), Positives = 421/873 (48%), Gaps = 62/873 (7%)
Query: 175 SDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMME--LDLVSLVLHIPVISIVRH-EFPRE 231
+DP S + VC + + L+ + E + LD +S +P++ I
Sbjct: 77 TDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMA 136
Query: 232 SQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLL--LCQEDWNITDFLLLTQNNSKF 289
++P S+ A V + I+ +W+ FSL+ + F+ T +NS F
Sbjct: 137 DKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNS-F 195
Query: 290 HLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMP 349
+ N+ S +D + Q+QL+ I +S V++ C + I G+
Sbjct: 196 VGWDMQNVITLDTSFEDAKT--QVQLKKIHSS---VILLYCSKDEAVLILSEARSLGLTG 250
Query: 350 PELRWVLGD--SQNVEELRTEGLPLGLIAHGKTTQSV-FEHYVQDAMELVARAVATATMI 406
+ W++ S N E + E P GLI+ E V+D + ++ A ++M+
Sbjct: 251 YDFFWIVPSLVSGNTELIPKE-FPSGLISVSYDDWDYSLEARVRDGIGILT--TAASSML 307
Query: 407 QPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIW 466
+ + + +C L F+ N T+ G S +G + +
Sbjct: 308 EKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQV---HPRLVVI 364
Query: 467 NLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQ-HPSKLHLRVVTLIEHPF 525
L D W ++G W+ + + + +WP R+K+ P HL +VTL E PF
Sbjct: 365 VLNKDRE----WEKVGKWENHTLSLRHAVWP----RYKSFSDCEPDDNHLSIVTLEEAPF 416
Query: 526 VFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLE 585
V ++D P + C+ ++ +S+N+ + +K KCC G+CID+L+
Sbjct: 417 VIVEDID-----PLTETCV----RNTVPCRKFVKINNSTNEGMNVK--KCCKGFCIDILK 465
Query: 586 KIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFT 645
K++ + F +DLY+V +GK+G N W G++G+++ A MAV S +IN RS+V+DF+
Sbjct: 466 KLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFS 525
Query: 646 SPFFSTSLGILV-RTRDTAAPIGAFMWPLHWTMWLGIFVALHI-TAVFLTLYEWKSPFGL 703
PF T + ++V R+ T +P AF+ P ++W+ +FV L I +A+ + ++E+ SP G
Sbjct: 526 VPFVETGISVMVSRSNGTVSP-SAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGY 584
Query: 704 T---PKGR-NRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLST 759
KG+ F+ A+ + + L+F +V ++ PK T + ++++WA F + L++
Sbjct: 585 NRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLAS 644
Query: 760 YTANLAAVMVGEKIYEELSGIHDPKLHHP---SQGFRFGTVRESSAEDYVRQSFPEMHEY 816
YTANLAA M+ E+ ++++G+ D K P S FRFGTV S E +R ++P MH+Y
Sbjct: 645 YTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQY 704
Query: 817 MRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKP--FAIEGYG 874
M ++N D + LK KLDAFI D A+L+Y+ D CKL+T+G FA GYG
Sbjct: 705 MTKFNQKGVEDALVSLKTG--KLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYG 762
Query: 875 IGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGL 934
I L SP I + Q+ G M+ L W + +++ ++ Q+ I + +G+
Sbjct: 763 IALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSS--QLDIDNMAGV 820
Query: 935 FVLLCIGFGLSILTTIGEHIVY---RLLLPRI-KNKSKLQYWLHTSQRLHRAINTSFIEE 990
F +L LS++T I EH+ Y R + ++ L + + S+ ++ I+ IEE
Sbjct: 821 FYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSI--SRGIYSCIHGVHIEE 878
Query: 991 KQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDN 1023
K++ +SN+ + N S++S+ N
Sbjct: 879 KKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMN 911
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 299 bits (765), Expect = 1e-80
Identities = 241/873 (27%), Positives = 421/873 (48%), Gaps = 62/873 (7%)
Query: 175 SDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMME--LDLVSLVLHIPVISIVRH-EFPRE 231
+DP S + VC + + L+ + E + LD +S +P++ I
Sbjct: 77 TDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMA 136
Query: 232 SQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLL--LCQEDWNITDFLLLTQNNSKF 289
++P S+ A V + I+ +W+ FSL+ + F+ T +NS F
Sbjct: 137 DKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNS-F 195
Query: 290 HLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMP 349
+ N+ S +D + Q+QL+ I +S V++ C + I G+
Sbjct: 196 VGWDMQNVITLDTSFEDAKT--QVQLKKIHSS---VILLYCSKDEAVLILSEARSLGLTG 250
Query: 350 PELRWVLGD--SQNVEELRTEGLPLGLIAHGKTTQSV-FEHYVQDAMELVARAVATATMI 406
+ W++ S N E + E P GLI+ E V+D + ++ A ++M+
Sbjct: 251 YDFFWIVPSLVSGNTELIPKE-FPSGLISVSYDDWDYSLEARVRDGIGILT--TAASSML 307
Query: 407 QPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIW 466
+ + + +C L F+ N T+ G S +G + +
Sbjct: 308 EKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQV---HPRLVVI 364
Query: 467 NLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQ-HPSKLHLRVVTLIEHPF 525
L D W ++G W+ + + + +WP R+K+ P HL +VTL E PF
Sbjct: 365 VLNKDRE----WEKVGKWENHTLSLRHAVWP----RYKSFSDCEPDDNHLSIVTLEEAPF 416
Query: 526 VFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLE 585
V ++D P + C+ ++ +S+N+ + +K KCC G+CID+L+
Sbjct: 417 VIVEDID-----PLTETCV----RNTVPCRKFVKINNSTNEGMNVK--KCCKGFCIDILK 465
Query: 586 KIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFT 645
K++ + F +DLY+V +GK+G N W G++G+++ A MAV S +IN RS+V+DF+
Sbjct: 466 KLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFS 525
Query: 646 SPFFSTSLGILV-RTRDTAAPIGAFMWPLHWTMWLGIFVALHI-TAVFLTLYEWKSPFGL 703
PF T + ++V R+ T +P AF+ P ++W+ +FV L I +A+ + ++E+ SP G
Sbjct: 526 VPFVETGISVMVSRSNGTVSP-SAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGY 584
Query: 704 T---PKGR-NRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLST 759
KG+ F+ A+ + + L+F +V ++ PK T + ++++WA F + L++
Sbjct: 585 NRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLAS 644
Query: 760 YTANLAAVMVGEKIYEELSGIHDPKLHHP---SQGFRFGTVRESSAEDYVRQSFPEMHEY 816
YTANLAA M+ E+ ++++G+ D K P S FRFGTV S E +R ++P MH+Y
Sbjct: 645 YTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQY 704
Query: 817 MRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKP--FAIEGYG 874
M ++N D + LK KLDAFI D A+L+Y+ D CKL+T+G FA GYG
Sbjct: 705 MTKFNQKGVEDALVSLKTG--KLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYG 762
Query: 875 IGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGL 934
I L SP I + Q+ G M+ L W + +++ ++ Q+ I + +G+
Sbjct: 763 IALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSS--QLDIDNMAGV 820
Query: 935 FVLLCIGFGLSILTTIGEHIVY---RLLLPRI-KNKSKLQYWLHTSQRLHRAINTSFIEE 990
F +L LS++T I EH+ Y R + ++ L + + S+ ++ I+ IEE
Sbjct: 821 FYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSI--SRGIYSCIHGVHIEE 878
Query: 991 KQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDN 1023
K++ +SN+ + N S++S+ N
Sbjct: 879 KKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMN 911
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 277 bits (708), Expect = 5e-74
Identities = 229/839 (27%), Positives = 388/839 (46%), Gaps = 77/839 (9%)
Query: 174 SSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMME--LDLVSLVLHIPVISIVRHEF--- 228
+++P S L +C + V ++ E + LD +S H+P++SI
Sbjct: 71 TTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVL 130
Query: 229 -PRESQNP-LHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFL-----L 281
P+E + L L +SLE L V +L +W F+++ + FL +
Sbjct: 131 TPKEPGSAFLQLGVSLEQQLQ----VLFKVLEEYDWSAFAVITSLHPGHAL-FLEGVRAV 185
Query: 282 LTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEI 341
++ + L ++ + + L QL++ P V + C E +F
Sbjct: 186 ADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDA-----PVFVAY-CSREEAEVLFAE 239
Query: 342 TTQFGVMPPELRWVLGD-SQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAV 400
Q G++ P W++ + + + P+GLI+ T+S Q + VA
Sbjct: 240 AAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLIS--VVTESWRLSLRQKVRDGVAILA 297
Query: 401 ATATMIQPELALIPSTMNCMEVETTNLTSG-QYLSRFLANTTFRGLS-----GSIRVKGS 454
A + +P+ V ++ + R L N T+ G G V+ +
Sbjct: 298 LGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPT 357
Query: 455 TIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHP-SKL 513
+V + N +W + +G W+ G + M Y +WP R+ Q
Sbjct: 358 MVVIALNRHRLWEM------------VGRWEHGVLYMKYPVWP----RYSASLQPVVDSR 401
Query: 514 HLRVVTLIEHPFVFTREVDD-EGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKF 572
HL V TL E PFV D G C + +N + SS D P
Sbjct: 402 HLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHT----------FSSGDVAPYT- 450
Query: 573 KKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSF 632
K CC G+CID+L+K+A + F +DLY+V +GK+G G W G++G++ A MA+ S
Sbjct: 451 KLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSL 510
Query: 633 SINTARSQVIDFTSPFFSTSLGILV-RTRDTAAPIGAFMWPLHWTMWLGIFV-ALHITAV 690
+IN RS+++DF+ PF T + ++V R+ T +P AF+ P +W+ +FV L + A+
Sbjct: 511 TINEERSEIVDFSVPFVETGISVMVARSNGTVSP-SAFLEPYSPAVWVMMFVMCLTVVAI 569
Query: 691 FLTLYEWKSPF----GLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLM 746
+ ++E+ SP LT ++ F+ ++ + +AL+F +V I+ P+ T + ++
Sbjct: 570 TVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMV 629
Query: 747 NLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQ---GFRFGTVRESSAE 803
+WA F + L++YTANLAA M+ E+ + +SG+ D K P FRFGTV S E
Sbjct: 630 LVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTE 689
Query: 804 DYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLT 863
+R ++ +MH +M ++N + D + LK KLDAFI D A+L+Y D CKL+T
Sbjct: 690 RNIRSNYRDMHTHMVKFNQRSVEDALTSLKMG--KLDAFIYDAAVLNYMAGKDEGCKLVT 747
Query: 864 V--GKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVT 921
+ GK FA GYGI + +S I + Q+ G L W + +++ ++
Sbjct: 748 IGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMS 807
Query: 922 ETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLH 980
L I + +G+F +L + GL++L EH+VY L + N S+L + L S+ ++
Sbjct: 808 SKLD--IDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIY 864
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 276 bits (707), Expect = 6e-74
Identities = 176/540 (32%), Positives = 276/540 (51%), Gaps = 39/540 (7%)
Query: 430 GQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKI 489
G+ L R+ N T+ S G + S + +L D W +GSW+ +
Sbjct: 357 GESLHRYFMNITWDNRDYSFNEDGFLVNPS---LVVISLTRDRT----WEVVGSWEQQTL 409
Query: 490 VMDYGIWPEQAQRHKTHFQHP--SKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPM 547
+ Y +W + F P HL V TL E PFV D P C+
Sbjct: 410 RLKYPLWSRYGR-----FLQPVDDTQHLTVATLEERPFVIVEPAD-----PISGTCI--- 456
Query: 548 TNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGA 607
DS S + HS P K+CC G+CID+L+++A + F +DLY+V +GK+G
Sbjct: 457 -RDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGK 515
Query: 608 WKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILV-RTRDTAAPI 666
+G W G++G++ A MA+ S +IN RS+++DF+ PF T + ++V R+ T +P
Sbjct: 516 KIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSP- 574
Query: 667 GAFMWPLHWTMWLGIFV-ALHITAVFLTLYEWKSPFG----LTPKGRNRSKVFSFSSALN 721
AF+ P +W+ +FV L + AV + ++E+ SP G L R F+ ++
Sbjct: 575 SAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIW 634
Query: 722 ICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIH 781
+ +AL+F +V ++ P+ T + ++ +WA F + L++YTANLAA M+ E+ + +SG+
Sbjct: 635 LLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLS 694
Query: 782 DPKLHHPSQGF---RFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEK 838
D K P + + +FGTV S E +R ++P+MH YM RYN P + + LK K
Sbjct: 695 DRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLK--AGK 752
Query: 839 LDAFIMDKALLDYEVSIDADCKLLTV--GKPFAIEGYGIGLPPNSPLTANISELISQYKS 896
LDAFI D A+L+Y D CKL+T+ GK FA GYGI L S I + Q+
Sbjct: 753 LDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLG 812
Query: 897 HGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVY 956
++ML W + C V + ++ I + +G+F +L + GLS+L EH+VY
Sbjct: 813 DDEIEMLERLWLSGI-CHNDKIEVMSS-KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVY 870
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 252 bits (643), Expect = 2e-66
Identities = 191/668 (28%), Positives = 332/668 (49%), Gaps = 71/668 (10%)
Query: 302 PSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGD--- 358
P T+++ + L K V++ + ++ + W++G+
Sbjct: 199 PGTKNVTALLM----EAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREI 254
Query: 359 SQNVEELRTEGLPLGL-IAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTM 417
S N +G+ LGL + +GK + ++ DA+ +VA+AV +++ E P
Sbjct: 255 SGNALRYAPDGI-LGLQLINGKNESA----HISDAVGVVAQAVHE--LLEKENITDPPR- 306
Query: 418 NCMEVETTNL-TSGQYLSRFLANTTFR-GLSGSIRVKGSTIVSSENNFFIWNLQHDPMGK 475
C V TN+ +G R L ++ + G++G + N + I NLQ+ +
Sbjct: 307 GC--VGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFAN-YSIMNLQNRKL-- 361
Query: 476 PMWTRLGSWQGGKIVMDYG--IWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDD 533
++G + G ++ + IWP +Q ++L ++VT+ + PFV+ +
Sbjct: 362 ---VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRL--KIVTIHQEPFVYVKPTLS 416
Query: 534 EGLC---------PAGQ-LCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDL 583
+G C P + +C P ND+S S TVP +CCYG+CIDL
Sbjct: 417 DGTCKEEFTVNGDPVKKVICTGP--NDTSP--------GSPRHTVP----QCCYGFCIDL 462
Query: 584 LEKIAEDMNFDFDLYIVGDGKYGAWKNGH------WTGLVGDLLRGTAHMAVTSFSINTA 637
L K+A MNF +++++V DGK+G + + W G++G+LL G A M V +IN
Sbjct: 463 LIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNE 522
Query: 638 RSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEW 697
R+Q I+F+ PF L ILV+ + + +FM P T+WL + +++H+ AV L L +
Sbjct: 523 RAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDR 582
Query: 698 KSPFG--LTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMF 755
SPFG + SSA+ + +L + P+ ++ R L +WA F M
Sbjct: 583 FSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
Query: 756 CLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ--SFPEM 813
+++YTANLAA +V ++ E ++GI+DP+L +PS F + TV++SS + Y R+ M
Sbjct: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTM 702
Query: 814 HEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGY 873
+ +M ++N + + ++ ++++ KL AFI D A+L++E S C L+T G+ F G+
Sbjct: 703 YRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEAS--QKCDLVTTGELFFRSGF 758
Query: 874 GIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSG 933
GIG+ +SP N+S I + +GFM+ L W R C RS A + ++ +G
Sbjct: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNA---PATLTFENMAG 815
Query: 934 LFVLLCIG 941
+F+L+ G
Sbjct: 816 VFMLVAGG 823
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 252 bits (643), Expect = 2e-66
Identities = 191/668 (28%), Positives = 332/668 (49%), Gaps = 71/668 (10%)
Query: 302 PSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGD--- 358
P T+++ + L K V++ + ++ + W++G+
Sbjct: 199 PGTKNVTALLM----EAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREI 254
Query: 359 SQNVEELRTEGLPLGL-IAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTM 417
S N +G+ LGL + +GK + ++ DA+ +VA+AV +++ E P
Sbjct: 255 SGNALRYAPDGI-LGLQLINGKNESA----HISDAVGVVAQAVHE--LLEKENITDPPR- 306
Query: 418 NCMEVETTNL-TSGQYLSRFLANTTFR-GLSGSIRVKGSTIVSSENNFFIWNLQHDPMGK 475
C V TN+ +G R L ++ + G++G + N + I NLQ+ +
Sbjct: 307 GC--VGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFAN-YSIMNLQNRKL-- 361
Query: 476 PMWTRLGSWQGGKIVMDYG--IWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDD 533
++G + G ++ + IWP +Q ++L ++VT+ + PFV+ +
Sbjct: 362 ---VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRL--KIVTIHQEPFVYVKPTLS 416
Query: 534 EGLC---------PAGQ-LCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDL 583
+G C P + +C P ND+S S TVP +CCYG+CIDL
Sbjct: 417 DGTCKEEFTVNGDPVKKVICTGP--NDTSP--------GSPRHTVP----QCCYGFCIDL 462
Query: 584 LEKIAEDMNFDFDLYIVGDGKYGAWKNGH------WTGLVGDLLRGTAHMAVTSFSINTA 637
L K+A MNF +++++V DGK+G + + W G++G+LL G A M V +IN
Sbjct: 463 LIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNE 522
Query: 638 RSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEW 697
R+Q I+F+ PF L ILV+ + + +FM P T+WL + +++H+ AV L L +
Sbjct: 523 RAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDR 582
Query: 698 KSPFG--LTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMF 755
SPFG + SSA+ + +L + P+ ++ R L +WA F M
Sbjct: 583 FSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
Query: 756 CLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ--SFPEM 813
+++YTANLAA +V ++ E ++GI+DP+L +PS F + TV++SS + Y R+ M
Sbjct: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTM 702
Query: 814 HEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGY 873
+ +M ++N + + ++ ++++ KL AFI D A+L++E S C L+T G+ F G+
Sbjct: 703 YRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEAS--QKCDLVTTGELFFRSGF 758
Query: 874 GIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSG 933
GIG+ +SP N+S I + +GFM+ L W R C RS A + ++ +G
Sbjct: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNA---PATLTFENMAG 815
Query: 934 LFVLLCIG 941
+F+L+ G
Sbjct: 816 VFMLVAGG 823
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 252 bits (643), Expect = 2e-66
Identities = 191/668 (28%), Positives = 332/668 (49%), Gaps = 71/668 (10%)
Query: 302 PSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGD--- 358
P T+++ + L K V++ + ++ + W++G+
Sbjct: 199 PGTKNVTALLM----EAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREI 254
Query: 359 SQNVEELRTEGLPLGL-IAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTM 417
S N +G+ LGL + +GK + ++ DA+ +VA+AV +++ E P
Sbjct: 255 SGNALRYAPDGI-LGLQLINGKNESA----HISDAVGVVAQAVHE--LLEKENITDPPR- 306
Query: 418 NCMEVETTNL-TSGQYLSRFLANTTFR-GLSGSIRVKGSTIVSSENNFFIWNLQHDPMGK 475
C V TN+ +G R L ++ + G++G + N + I NLQ+ +
Sbjct: 307 GC--VGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFAN-YSIMNLQNRKL-- 361
Query: 476 PMWTRLGSWQGGKIVMDYG--IWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDD 533
++G + G ++ + IWP +Q ++L ++VT+ + PFV+ +
Sbjct: 362 ---VQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRL--KIVTIHQEPFVYVKPTLS 416
Query: 534 EGLC---------PAGQ-LCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDL 583
+G C P + +C P ND+S S TVP +CCYG+CIDL
Sbjct: 417 DGTCKEEFTVNGDPVKKVICTGP--NDTSP--------GSPRHTVP----QCCYGFCIDL 462
Query: 584 LEKIAEDMNFDFDLYIVGDGKYGAWKNGH------WTGLVGDLLRGTAHMAVTSFSINTA 637
L K+A MNF +++++V DGK+G + + W G++G+LL G A M V +IN
Sbjct: 463 LIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNE 522
Query: 638 RSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEW 697
R+Q I+F+ PF L ILV+ + + +FM P T+WL + +++H+ AV L L +
Sbjct: 523 RAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDR 582
Query: 698 KSPFG--LTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMF 755
SPFG + SSA+ + +L + P+ ++ R L +WA F M
Sbjct: 583 FSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
Query: 756 CLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ--SFPEM 813
+++YTANLAA +V ++ E ++GI+DP+L +PS F + TV++SS + Y R+ M
Sbjct: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTM 702
Query: 814 HEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGY 873
+ +M ++N + + ++ ++++ KL AFI D A+L++E S C L+T G+ F G+
Sbjct: 703 YRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEAS--QKCDLVTTGELFFRSGF 758
Query: 874 GIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSG 933
GIG+ +SP N+S I + +GFM+ L W R C RS A + ++ +G
Sbjct: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNA---PATLTFENMAG 815
Query: 934 LFVLLCIG 941
+F+L+ G
Sbjct: 816 VFMLVAGG 823
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 162 bits (410), Expect = 2e-39
Identities = 160/661 (24%), Positives = 282/661 (42%), Gaps = 91/661 (13%)
Query: 324 TVVMFGCDMESIRRIFEITTQFGVMP---PELRWVLGDSQNVEELRTEGLP-LGLIAHGK 379
T+ +F D+E R T F ++ P + ++ + ++E L+ P GL+
Sbjct: 259 TLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSII-EKWSMERLQAPPRPETGLLDGMM 317
Query: 380 TTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLAN 439
TT++ + DA+ +VA A A+ L S++ C + L G +
Sbjct: 318 TTEAALMY---DAVYMVAIASHRASQ------LTVSSLQCHRHKPWRL--GPRFMNLIKE 366
Query: 440 TTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKP----------MWTRLGSWQGGKI 489
+ GL+G I + + + + I +L+ + K +W ++G W
Sbjct: 367 ARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNS- 425
Query: 490 VMDYGIWPEQAQRHKTHFQHPSKLH--LRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPM 547
G+ + + K+ S + L V T++E P+V R+ D
Sbjct: 426 ----GLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDK-------------- 467
Query: 548 TNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGA 607
P+ GYC+DLL++++ + F +D+ +V DGKYGA
Sbjct: 468 ---------------------PLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGA 506
Query: 608 WKN-GHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP- 665
+ G W G+V +L+ A +AV +I R +VIDF+ PF + + IL R + P
Sbjct: 507 QNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPG 566
Query: 666 IGAFMWPLHWTMW-------LGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSS 718
+ +F+ PL +W LG+ L + A F T YEW +P P F+ +
Sbjct: 567 VFSFLNPLSPDIWMYVLLACLGVSCVLFVIARF-TPYEWYNPHPCNPDSDVVENNFTLLN 625
Query: 719 ALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELS 778
+ L + + PK + R + +W F + +S+YTANLAA + E++ +
Sbjct: 626 SFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPID 684
Query: 779 GIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEK 838
D +G VR+ S + ++S ++ Y + + ++ ++N E
Sbjct: 685 SADDLA---KQTKIEYGAVRDGSTMTFFKKS--KISTYEKMWAFMSSRQQTALVRNSDEG 739
Query: 839 LDAFI-MDKALLDYEVSID----ADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQ 893
+ + D ALL SI+ +C L +G +GYG+G P SP I+ I Q
Sbjct: 740 IQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQ 799
Query: 894 YKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEH 953
+ G + M+ +KW+R C + E +G+++ G+F++L G LS+ IGE
Sbjct: 800 LQEEGKLHMMKEKWWRGNGCPEED--NKEASALGVENIGGIFIVLAAGLVLSVFVAIGEF 857
Query: 954 I 954
I
Sbjct: 858 I 858
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 162 bits (409), Expect = 2e-39
Identities = 112/391 (28%), Positives = 189/391 (48%), Gaps = 23/391 (5%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKN-GHWTGLVGDLLRGTAHMAVTSFSINT 636
GYC+DLL++++ + F +D+ +V DGKYGA + G W G+V +L+ A +AV +I
Sbjct: 462 GYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITY 521
Query: 637 ARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW-------LGIFVALHIT 688
R +VIDF+ PF + + IL R + P + +F+ PL +W LG+ L +
Sbjct: 522 VREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVI 581
Query: 689 AVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNL 748
A F T YEW +P P F+ ++ L + + PK + R + +
Sbjct: 582 ARF-TPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGI 639
Query: 749 WAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ 808
W F + +S+YTANLAA + E++ + D +G VR+ S + ++
Sbjct: 640 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA---KQTKIEYGAVRDGSTMTFFKK 696
Query: 809 SFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFI-MDKALLDYEVSID----ADCKLLT 863
S ++ Y + + ++ ++N E + + D ALL SI+ +C L
Sbjct: 697 S--KISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQ 754
Query: 864 VGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTET 923
+G +GYG+G P SP I+ I Q + G + M+ +KW+R C + E
Sbjct: 755 IGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEED--NKEA 812
Query: 924 LQMGIKHFSGLFVLLCIGFGLSILTTIGEHI 954
+G+++ G+F++L G LS+ IGE I
Sbjct: 813 SALGVENIGGIFIVLAAGLVLSVFVAIGEFI 843
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 159 bits (401), Expect = 2e-38
Identities = 121/466 (25%), Positives = 215/466 (46%), Gaps = 43/466 (9%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLVGDLLRGTAHMAVTSFSIN 635
GYCIDLL +++ + F +++ +V DGKYGA NG W G+V +L+ A +AV +I
Sbjct: 461 GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAIT 520
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVA-LHITAVFLT 693
R +VIDF+ PF + + IL R + P + +F+ PL +W+ I +A L ++ V
Sbjct: 521 YVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFV 580
Query: 694 L-----YEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNL 748
+ YEW +P P F+ ++ L + + PK + R + +
Sbjct: 581 IARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGI 639
Query: 749 WAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ 808
W F + +S+YTANLAA + E++ + D +G V + + + ++
Sbjct: 640 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA---KQTKIEYGAVEDGATMTFFKK 696
Query: 809 S----FPEMHEYM--RRYN--VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCK 860
S + +M +M RR + V + +G++ + AF+M+ +++ +C
Sbjct: 697 SKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY---AFLMESTTIEFVT--QRNCN 751
Query: 861 LLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAV 920
L +G +GYG+G P SP I+ I Q + G + M+ +KW+R C +
Sbjct: 752 LTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEE--S 809
Query: 921 TETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLH 980
E +G+++ G+F++L G LS+ +GE + KSK +Q
Sbjct: 810 KEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY----------KSK-----KNAQLEK 854
Query: 981 RAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRK 1026
R+ ++ +EE + K +R K P + N+ N R+
Sbjct: 855 RSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR 900
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 158 bits (400), Expect = 2e-38
Identities = 114/397 (28%), Positives = 196/397 (49%), Gaps = 28/397 (7%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGH--WTGLVGDLLRGTAHMAVTSFSIN 635
GYC+DL +IA+ F + L IVGDGKYGA W G+VG+L+ G A +A+ +I
Sbjct: 397 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTIT 456
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW-------LGIFVALHI 687
R +VIDF+ PF S + I+++ + P + +F+ PL + +W +G+ V L +
Sbjct: 457 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 516
Query: 688 TAVFLTLYEWKS-PFGLTPKGRNRSKVFSFSSALNICYAL-LFGRTVAIKPPKCWTGRFL 745
+ F + YEW + F + ++ F ++ ++L F R P+ +GR +
Sbjct: 517 VSRF-SPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIV 575
Query: 746 MNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDY 805
+W F + +S+YTANLAA + E++ + D +GT+ S +++
Sbjct: 576 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS---KQTEIAYGTLDSGSTKEF 632
Query: 806 VRQS----FPEMHEYMRRYN----VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDA 857
R+S F +M YMR V T +GV ++ K A++++ + +Y +
Sbjct: 633 FRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY-AYLLESTMNEY-IEQRK 690
Query: 858 DCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK-WYRVVPCG-K 915
C + VG +GYGI P S L ++ + + G +D L +K WY CG K
Sbjct: 691 PCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAK 750
Query: 916 RSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGE 952
S + +T + + + +G+F +L G GL++L + E
Sbjct: 751 DSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE 787
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 158 bits (400), Expect = 2e-38
Identities = 114/397 (28%), Positives = 196/397 (49%), Gaps = 28/397 (7%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGH--WTGLVGDLLRGTAHMAVTSFSIN 635
GYC+DL +IA+ F + L IVGDGKYGA W G+VG+L+ G A +A+ +I
Sbjct: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTIT 503
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW-------LGIFVALHI 687
R +VIDF+ PF S + I+++ + P + +F+ PL + +W +G+ V L +
Sbjct: 504 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 563
Query: 688 TAVFLTLYEWKS-PFGLTPKGRNRSKVFSFSSALNICYAL-LFGRTVAIKPPKCWTGRFL 745
+ F + YEW + F + ++ F ++ ++L F R P+ +GR +
Sbjct: 564 VSRF-SPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIV 622
Query: 746 MNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDY 805
+W F + +S+YTANLAA + E++ + D +GT+ S +++
Sbjct: 623 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS---KQTEIAYGTLDSGSTKEF 679
Query: 806 VRQS----FPEMHEYMRRYN----VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDA 857
R+S F +M YMR V T +GV ++ K A++++ + +Y +
Sbjct: 680 FRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY-AYLLESTMNEY-IEQRK 737
Query: 858 DCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK-WYRVVPCG-K 915
C + VG +GYGI P S L ++ + + G +D L +K WY CG K
Sbjct: 738 PCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAK 797
Query: 916 RSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGE 952
S + +T + + + +G+F +L G GL++L + E
Sbjct: 798 DSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE 834
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 157 bits (397), Expect = 5e-38
Identities = 110/413 (26%), Positives = 199/413 (48%), Gaps = 30/413 (7%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLVGDLLRGTAHMAVTSFSIN 635
GYCIDLL +++ + F +++ +V DGKYGA NG W G+V +L+ A +AV +I
Sbjct: 461 GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAIT 520
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVA-LHITAVFLT 693
R +VIDF+ PF + + IL R + P + +F+ PL +W+ I +A L ++ V
Sbjct: 521 YVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFV 580
Query: 694 L-----YEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNL 748
+ YEW +P P F+ ++ L + + PK + R + +
Sbjct: 581 IARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGI 639
Query: 749 WAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ 808
W F + +S+YTANLAA + E++ + D +G V + + + ++
Sbjct: 640 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA---KQTKIEYGAVEDGATMTFFKK 696
Query: 809 S----FPEMHEYM--RRYN--VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCK 860
S + +M +M RR + V + +G++ + AF+M+ +++ +C
Sbjct: 697 SKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY---AFLMESTTIEFVT--QRNCN 751
Query: 861 LLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAV 920
L +G +GYG+G P SP I+ I Q + G + M+ +KW+R C +
Sbjct: 752 LTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEE--S 809
Query: 921 TETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWL 973
E +G+++ G+F++L G LS+ +GE + +++ +S + WL
Sbjct: 810 KEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKESSI--WL 860
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 157 bits (396), Expect = 7e-38
Identities = 120/432 (27%), Positives = 208/432 (48%), Gaps = 34/432 (7%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLVGDLLRGTAHMAVTSFSIN 635
GYC++L +IA+ + + + L IV DGKYGA W G+VG+L+ G A +AV +I
Sbjct: 437 GYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTIT 496
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW-------LGIFVALHI 687
R +VIDF+ PF S + I+++ + P + +F+ PL + +W +G+ V L +
Sbjct: 497 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 556
Query: 688 TAVFLTLYEWKS---PFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRF 744
+ F + YEW S G ++S F ++L + I P+ +GR
Sbjct: 557 VSRF-SPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDIS-PRSLSGRI 614
Query: 745 LMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAED 804
+ +W F + +S+YTANLAA + E++ + D +GT+ S ++
Sbjct: 615 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGTLEAGSTKE 671
Query: 805 YVRQS----FPEMHEYMRRYN----VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSID 856
+ R+S F +M YM+ V T +G+ ++ K A++++ + +Y +
Sbjct: 672 FFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKY-AYLLESTMNEY-IEQR 729
Query: 857 ADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK-WYRVVPCG- 914
C + VG +GYGI P S L ++ + + G +D L K WY CG
Sbjct: 730 KPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGS 789
Query: 915 KRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLH 974
K S + +T + + + +G+F +L G GL++L + E Y+ R ++K + L
Sbjct: 790 KDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIE-FCYK---SRSESKRMKGFCLI 845
Query: 975 TSQRLHRAINTS 986
Q ++ AI TS
Sbjct: 846 PQQSINEAIRTS 857
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 155 bits (391), Expect = 3e-37
Identities = 113/397 (28%), Positives = 193/397 (48%), Gaps = 28/397 (7%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGH--WTGLVGDLLRGTAHMAVTSFSIN 635
GYC+DL +IA+ F + L IVGDGKYGA W G+VG+L+ G A +A+ +I
Sbjct: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTIT 503
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW-------LGIFVALHI 687
R +VIDF+ PF S + I+++ + P + +F+ PL + +W +G+ V L +
Sbjct: 504 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 563
Query: 688 TAVFLTLYEWKS-PFGLTPKGRNRSKVFSFSSALNICYAL-LFGRTVAIKPPKCWTGRFL 745
+ F + YEW + F + ++ F ++ ++L F R P+ +GR +
Sbjct: 564 VSRF-SPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIV 622
Query: 746 MNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDY 805
+W F + +S+YTANLAA + E++ + D +GT+ S +++
Sbjct: 623 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS---KQTEIAYGTLDSGSTKEF 679
Query: 806 VRQS----FPEMHEYMRRYN----VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDA 857
R+S F +M YMR V T +GV ++ K A++++ + +Y +
Sbjct: 680 FRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY-AYLLESTMNEY-IEQRK 737
Query: 858 DCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK-WYRVVPCGKR 916
C + VG +GYGI P S L ++ + + G +D L +K WY CG
Sbjct: 738 PCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG 797
Query: 917 SFAVTE-TLQMGIKHFSGLFVLLCIGFGLSILTTIGE 952
E T + + + +G+F +L G GL++L + E
Sbjct: 798 GGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE 834
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 154 bits (388), Expect = 6e-37
Identities = 112/398 (28%), Positives = 191/398 (47%), Gaps = 28/398 (7%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAW--KNGHWTGLVGDLLRGTAHMAVTSFSIN 635
GYC+DL +IA+ + + L IVGDGKYGA + W G+VG+L+ G A +AV +I
Sbjct: 453 GYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTIT 512
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVALHITAVFLTL 694
R +VIDF+ PF S + I+++ + P + +F+ PL + +W+ I A +V L L
Sbjct: 513 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 572
Query: 695 YEWKSPFGLTPKGRNRSKVFSFS-----SALNICYALLFGRTVAIK-----PPKCWTGRF 744
SP+ + N S + I +L F ++ P+ +GR
Sbjct: 573 VSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRI 632
Query: 745 LMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAED 804
+ +W F + +S+YTANLAA + E++ + D +GT+ S ++
Sbjct: 633 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGTLDSGSTKE 689
Query: 805 YVRQSFPEMHEYMRRYNVPATP--------DGVEYLKNDPEKLDAFIMDKALLDYEVSID 856
+ R+S ++E M Y A P DGV ++ K AF+++ + +Y +
Sbjct: 690 FFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKF-AFLLESTMNEY-IEQR 747
Query: 857 ADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK-WYRVVPCG- 914
C + VG +GYG+ P S L ++ + + G +D L +K WY CG
Sbjct: 748 KPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGA 807
Query: 915 KRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGE 952
K S + +T + + + +G+F +L G GL+++ + E
Sbjct: 808 KDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 845
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 153 bits (387), Expect = 8e-37
Identities = 111/394 (28%), Positives = 190/394 (48%), Gaps = 23/394 (5%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKN-GHWTGLVGDLLRGTAHMAVTSFSINT 636
GYCIDLL+++A + F +++ +V DGKYGA + G W G+V +L+ A +AV +I
Sbjct: 464 GYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITH 523
Query: 637 ARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVA-LHITAVFLTL 694
R + IDF+ PF + + IL R + P + +F+ PL +W+ + +A L ++ V +
Sbjct: 524 VREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVI 583
Query: 695 -----YEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLW 749
YEW P F+ ++ L + + PK + R + +W
Sbjct: 584 ARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELM-PKALSTRIIGGIW 642
Query: 750 AIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQS 809
F + +S+YTANLAA + E++ + D +G V++ + + ++S
Sbjct: 643 WFFTLIIISSYTANLAAFLTVERMESPIDSADDLA---KQTKIEYGAVKDGATMTFFKKS 699
Query: 810 FPEMHEYMRRYNVPATPDGVEYLKNDPEKLD-AFIMDKALLDYEVSID----ADCKLLTV 864
E M + + + P + +KN+ E + A D ALL +I+ +C L +
Sbjct: 700 KISTFEKMWAF-MSSKPSAL--VKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQI 756
Query: 865 GKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETL 924
G +GYGIG P SP I+ I Q + + ++ +KW+R C + E
Sbjct: 757 GGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEE--NKEAS 814
Query: 925 QMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRL 958
+GI+ G+F++L G LS+L +GE VY+L
Sbjct: 815 ALGIQKIGGIFIVLAAGLVLSVLVAVGE-FVYKL 847
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 153 bits (387), Expect = 8e-37
Identities = 118/432 (27%), Positives = 207/432 (47%), Gaps = 34/432 (7%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLVGDLLRGTAHMAVTSFSIN 635
GYC++L +IA+ + + + L IV DGKYGA W G+VG+L+ G A +AV +I
Sbjct: 437 GYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTIT 496
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW-------LGIFVALHI 687
R +VIDF+ PF S + I+++ + P + +F+ PL + +W +G+ V L +
Sbjct: 497 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 556
Query: 688 TAVFLTLYEWKS---PFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRF 744
+ F + YEW S G ++S F ++L + I P+ +GR
Sbjct: 557 VSRF-SPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDIS-PRSLSGRI 614
Query: 745 LMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAED 804
+ +W F + +S+YTANLAA + E++ + D +GT+ S ++
Sbjct: 615 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGTLEAGSTKE 671
Query: 805 YVRQS----FPEMHEYMRRYN----VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSID 856
+ R+S F +M YM+ V T +G+ ++ K A++++ + +Y +
Sbjct: 672 FFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKY-AYLLESTMNEY-IEQR 729
Query: 857 ADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK-WYRVVPCGK 915
C + VG +GYGI P S L ++ + + G +D L +K WY CG
Sbjct: 730 KPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 789
Query: 916 -RSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLH 974
+ +T + + + +G+F +L G GL++L + E Y+ R ++K + L
Sbjct: 790 GGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIE-FCYK---SRSESKRMKGFCLI 845
Query: 975 TSQRLHRAINTS 986
Q ++ AI TS
Sbjct: 846 PQQSINEAIRTS 857
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 149 bits (377), Expect = 1e-35
Identities = 110/398 (27%), Positives = 189/398 (47%), Gaps = 28/398 (7%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAW--KNGHWTGLVGDLLRGTAHMAVTSFSIN 635
GYC+DL +IA+ + + L IVGDGKYGA + W G+VG+L+ G A +AV +I
Sbjct: 453 GYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTIT 512
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVALHITAVFLTL 694
R +VIDF+ PF S + I+++ + P + +F+ PL + +W+ I A +V L L
Sbjct: 513 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 572
Query: 695 YEWKSPFGLTPKGRNRSKVFSFS-----SALNICYALLFGRTVAIK-----PPKCWTGRF 744
SP+ + N S + I +L F ++ P+ +GR
Sbjct: 573 VSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRI 632
Query: 745 LMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAED 804
+ +W F + +S+YTANLAA + E++ + D +GT+ S ++
Sbjct: 633 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGTLDSGSTKE 689
Query: 805 YVRQSFPEMHEYMRRYNVPATP--------DGVEYLKNDPEKLDAFIMDKALLDYEVSID 856
+ R+S ++E M Y A P DGV ++ K AF+++ + +Y +
Sbjct: 690 FFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKF-AFLLESTMNEY-IEQR 747
Query: 857 ADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK-WYRVVPCGK 915
C + VG +GYG+ P S L ++ + + G +D L +K WY CG
Sbjct: 748 KPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 807
Query: 916 -RSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGE 952
+ +T + + + +G+F +L G GL+++ + E
Sbjct: 808 GGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 845
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 149 bits (376), Expect = 1e-35
Identities = 114/447 (25%), Positives = 207/447 (46%), Gaps = 37/447 (8%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGA-WKNGHWTGLVGDLLRGTAHMAVTSFSINT 636
G+ ID+L+ ++ + F++++Y+ D KYG+ ++G W GLVG+L+ A + +++ +I
Sbjct: 469 GFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITP 528
Query: 637 ARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYE 696
R V+DFT+ + S+G+L+R + + A + P ++W I + + + + L
Sbjct: 529 DRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLN 588
Query: 697 WKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFC 756
W +P L + +++ + + G P R +M W +F +
Sbjct: 589 WLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEV----PYTTLATRMMMGAWWLFALIV 644
Query: 757 LSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQS------- 809
+S+YTANLAA + +I + + D +GTV +S+ ++VR
Sbjct: 645 ISSYTANLAAFLTITRIESSIQSLQDLS---KQTEIPYGTVLDSAVYEHVRMKGLNPFER 701
Query: 810 ---FPEMHEYMRR-----YNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKL 861
+ +M + R NV + G++ +K AF+ D A+L+Y D DC
Sbjct: 702 DSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNY---AFVWDAAVLEYVAINDPDCSF 758
Query: 862 LTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWY-RVVPCGKRSFAV 920
T+G A GYGI L SP S+ I + + +G MD+L KW+ + C ++
Sbjct: 759 YTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCD--LYSS 816
Query: 921 TETLQMG----IKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTS 976
+T Q G IK F+G+F +L G LS + E + R+ +K +
Sbjct: 817 VDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKE--IDL 874
Query: 977 QRLHRAINTSFIEEKQQH--FKTKRVE 1001
+ LHR +N+ ++ H F T ++
Sbjct: 875 EHLHRRVNSLCTDDDSPHKQFSTSSID 901
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 149 bits (375), Expect = 2e-35
Identities = 109/397 (27%), Positives = 193/397 (48%), Gaps = 28/397 (7%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGH--WTGLVGDLLRGTAHMAVTSFSIN 635
GYC+DL +IA+ + + + IV DGKYGA W G+VG+L+ G A +A+ +I
Sbjct: 445 GYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTIT 504
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW-------LGIFVALHI 687
R +VIDF+ PF S + I+++ + P + +F+ PL + +W +G+ V L +
Sbjct: 505 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 564
Query: 688 TAVFLTLYEWKSPFGLTPK-GRNRSKVFSFSSALNICYAL-LFGRTVAIKPPKCWTGRFL 745
+ F + YEW + K G + F ++ ++L F + P+ +GR +
Sbjct: 565 VSRF-SPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIV 623
Query: 746 MNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDY 805
+W F + +S+YTANLAA + E++ + D +GT+ S +++
Sbjct: 624 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGTLDSGSTKEF 680
Query: 806 VRQSFPEMHEYMRRYNVPATP--------DGVEYLKNDPEKLDAFIMDKALLDYEVSIDA 857
R+S ++E M Y A P +GV ++ K AF+++ + +Y +
Sbjct: 681 FRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKF-AFLLESTMNEY-IEQRK 738
Query: 858 DCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK-WYRVVPCG-K 915
C + VG +GYG+ P S L ++ + + G +D L +K WY CG K
Sbjct: 739 PCDTMKVGGNLDSKGYGVATPKGSSLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPK 798
Query: 916 RSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGE 952
S + +T + + + +G+F +L G GL++L + E
Sbjct: 799 DSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIE 835
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 147 bits (370), Expect = 7e-35
Identities = 109/397 (27%), Positives = 194/397 (48%), Gaps = 34/397 (8%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK-NGHWTGLVGDLLRGTAHMAVTSFSINT 636
G+C+D+L+++AE + F++ + +VGDG YG + NG WTG+VG+L+ A +AV +I
Sbjct: 446 GFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITA 505
Query: 637 ARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVA-LHITAVF--- 691
R +VIDF+ PF + + IL R P +F+ P +WL + +A L ++ V
Sbjct: 506 EREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLV 565
Query: 692 --LTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYA----LLFGRTVAIKPPKCWTGRFL 745
LT YEW SP +GR V +S ++ + + G T+A P+ + R +
Sbjct: 566 ARLTPYEWYSPHPCA-QGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIA---PRALSTRCV 621
Query: 746 MNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDY 805
+W F + +S+YTANLAA + +++ + + D +GT+ S+ +
Sbjct: 622 SGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA---DQTAIEYGTIHGGSSMTF 678
Query: 806 VRQSFPEMHEYMRRYN--------VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDA 857
+ S + ++ M Y V +T +G+ + N AF+++ + +Y
Sbjct: 679 FQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNY---AFLLESTMNEY--YRQR 733
Query: 858 DCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRS 917
+C L +G +GYGIG+P S I Q + + +++L KW+ C K
Sbjct: 734 NCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEE 793
Query: 918 FAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHI 954
+ L G+++ G+FV+L G ++I + E +
Sbjct: 794 DHRAKGL--GMENIGGIFVVLICGLIVAIFMAMLEFL 828
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 146 bits (368), Expect = 1e-34
Identities = 109/396 (27%), Positives = 191/396 (48%), Gaps = 32/396 (8%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK-NGHWTGLVGDLLRGTAHMAVTSFSINT 636
G+C+D+L ++AE + F + L +V DG YGA + NG WTG+VG+L+ A +AV +F+I
Sbjct: 445 GFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITA 504
Query: 637 ARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVA-LHITAVF--- 691
R +VIDF+ PF + + IL R P +F+ P +WL + +A L ++ V
Sbjct: 505 EREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLA 564
Query: 692 --LTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFG---RTVAIKPPKCWTGRFLM 746
L+ YEW +P P R R + L G + + P+ + R +
Sbjct: 565 ARLSPYEWYNPH---PCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVS 621
Query: 747 NLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYV 806
+W F + +S+YTANLAA + +++ + D +GT+ S +
Sbjct: 622 GVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLA---DQTNIEYGTIHAGSTMTFF 678
Query: 807 R----QSFPEMHEYMRRYN----VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDAD 858
+ Q++ M YM+ V +T +G+ + N AF+++ + +Y + +
Sbjct: 679 QNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY---AFLLESTMNEYHRRL--N 733
Query: 859 CKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSF 918
C L +G +GYGIG+P SP I+ I Q + + +++L KW+ C K
Sbjct: 734 CNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEED 793
Query: 919 AVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHI 954
+ L G+++ G+F++L G +++ + E I
Sbjct: 794 HRAKGL--GMENIGGIFIVLICGLIIAVFVAVMEFI 827
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 145 bits (367), Expect = 2e-34
Identities = 107/397 (26%), Positives = 191/397 (48%), Gaps = 28/397 (7%)
Query: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGH--WTGLVGDLLRGTAHMAVTSFSIN 635
GYC+DL +IA+ + + + IV DGKYGA W G+VG+L+ G A +A+ +I
Sbjct: 445 GYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTIT 504
Query: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW-------LGIFVALHI 687
R +VIDF+ PF S + I+++ + P + +F+ PL + +W +G+ V L +
Sbjct: 505 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 564
Query: 688 TAVFLTLYEWKSPFGLTPK-GRNRSKVFSFSSALNICYAL-LFGRTVAIKPPKCWTGRFL 745
+ F + YEW + K G + F ++ ++L F + P+ +GR +
Sbjct: 565 VSRF-SPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIV 623
Query: 746 MNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDY 805
+W F + +S+YTANLAA + E++ + D +GT+ S +++
Sbjct: 624 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGTLDSGSTKEF 680
Query: 806 VRQSFPEMHEYMRRYNVPATP--------DGVEYLKNDPEKLDAFIMDKALLDYEVSIDA 857
R+S ++E M Y A P +GV ++ K AF+++ + +Y +
Sbjct: 681 FRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKF-AFLLESTMNEY-IEQRK 738
Query: 858 DCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK-WYRVVPCGK- 915
C + VG +GYG+ P S L ++ + + G +D L +K WY CG
Sbjct: 739 PCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG 798
Query: 916 RSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGE 952
+ +T + + + +G+F +L G GL++L + E
Sbjct: 799 GGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIE 835
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 135 bits (341), Expect = 2e-31
Identities = 129/552 (23%), Positives = 231/552 (41%), Gaps = 70/552 (12%)
Query: 415 STMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMG 474
+++NC+ T G+ + + GL+G + + + + + G
Sbjct: 347 ASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFG 406
Query: 475 KPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDE 534
K M +L +W K + G E+ + L L+VVT++E PFV E
Sbjct: 407 KDM-RKLATWDSEKGLN--GSLQERPMGSRLQ-----GLTLKVVTVLEEPFVMVAENI-- 456
Query: 535 GLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFD 594
GQ P ++K G+ ID+L+ +A+ + F
Sbjct: 457 ----LGQ---------------------------PKRYK----GFSIDVLDALAKALGFK 481
Query: 595 FDLYIVGDGKYG-AWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSL 653
+++Y DG+YG N W G++G+L+ A +A+++ +I R V+DF+ + S+
Sbjct: 482 YEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSV 541
Query: 654 GILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNR-SK 712
GIL++ + I + P + +W I A+ + V + + + R S
Sbjct: 542 GILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSA 601
Query: 713 VFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEK 772
+ SA+ I Y F + R +M W +F + S+YTANLAA + +
Sbjct: 602 SATLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR 660
Query: 773 IYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVR----------QSFPEMHEYMRRY-- 820
+ + D +GTVR+S+ +Y R +F E+ + +
Sbjct: 661 MDNPIRTFQDLS---KQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGG 717
Query: 821 --NVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLP 878
N ++P E ++ + AF+ D A+++Y D DC + +G + +GYGI L
Sbjct: 718 ADNCVSSPS--EGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQ 775
Query: 879 PNSPLTANISELISQYKSHGFMDMLHDKWY-RVVPCGKRSFAVTETLQMGIK--HFSGLF 935
SP S+ I + + G +D+L KW+ + C S A + +K F+G+F
Sbjct: 776 HGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVF 835
Query: 936 VLLCIGFGLSIL 947
+L IG L+ L
Sbjct: 836 CILAIGLLLACL 847
>gi|68989256 ras inhibitor RIN1 [Homo sapiens]
Length = 783
Score = 43.5 bits (101), Expect = 0.001
Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 7/79 (8%)
Query: 18 PPPCALVLAGVPSSSSHPQPCQILKR---IGHAVRVGAVHLQPWTTAPRAASRAPDDSRA 74
PPP ++ VPS + PCQ+L+R +G+ V G+ P P + + D
Sbjct: 264 PPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLP----PMPSLQEVDCGSP 319
Query: 75 GAQRDEPEPGTRRSPAPSP 93
+ +E PG+R SPA SP
Sbjct: 320 SSSEEEGVPGSRGSPATSP 338
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,230,397
Number of Sequences: 37866
Number of extensions: 2129084
Number of successful extensions: 8149
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 92
Number of HSP's that attempted gapping in prelim test: 7753
Number of HSP's gapped (non-prelim): 354
length of query: 1115
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1002
effective length of database: 13,968,660
effective search space: 13996597320
effective search space used: 13996597320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.