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Search of human proteins with 222144293
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222144293 karyopherin alpha 1 [Homo sapiens]
(538 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222144293 karyopherin alpha 1 [Homo sapiens] 1067 0.0
gi|6912478 karyopherin alpha 6 [Homo sapiens] 868 0.0
gi|39812229 karyopherin alpha 5 [Homo sapiens] 865 0.0
gi|4504901 karyopherin alpha 4 [Homo sapiens] 462 e-130
gi|34485722 karyopherin alpha 3 [Homo sapiens] 462 e-130
gi|4504897 karyopherin alpha 2 [Homo sapiens] 439 e-123
gi|224589129 karyopherin 7 [Homo sapiens] 379 e-105
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 78 2e-14
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 78 2e-14
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [... 57 4e-08
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [... 57 4e-08
gi|189409124 armadillo repeat containing 3 [Homo sapiens] 51 2e-06
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens] 50 7e-06
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 47 4e-05
gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6 [... 46 1e-04
gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens] 42 0.002
gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens] 42 0.002
gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens] 42 0.002
gi|211059433 coiled-coil domain containing 79 [Homo sapiens] 37 0.035
gi|53829376 plakophilin 4 isoform b [Homo sapiens] 36 0.078
gi|53829374 plakophilin 4 isoform a [Homo sapiens] 36 0.078
gi|4504811 junction plakoglobin [Homo sapiens] 36 0.078
gi|12056468 junction plakoglobin [Homo sapiens] 36 0.078
gi|24308089 chromodomain helicase DNA binding protein 5 [Homo sa... 36 0.078
gi|31657114 armadillo repeat containing 4 [Homo sapiens] 35 0.17
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 34 0.30
gi|148746195 trichohyalin [Homo sapiens] 34 0.30
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin... 34 0.30
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [... 34 0.39
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [... 34 0.39
>gi|222144293 karyopherin alpha 1 [Homo sapiens]
Length = 538
Score = 1067 bits (2759), Expect = 0.0
Identities = 538/538 (100%), Positives = 538/538 (100%)
Query: 1 MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEE 60
MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEE
Sbjct: 1 MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEE 60
Query: 61 VMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDE 120
VMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDE
Sbjct: 61 VMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDE 120
Query: 121 VISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSS 180
VISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSS
Sbjct: 121 VISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSS 180
Query: 181 EFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLC 240
EFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLC
Sbjct: 181 EFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLC 240
Query: 241 RGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRR 300
RGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRR
Sbjct: 241 RGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRR 300
Query: 301 LVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACW 360
LVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACW
Sbjct: 301 LVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACW 360
Query: 361 TISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLV 420
TISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLV
Sbjct: 361 TISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLV 420
Query: 421 ELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDK 480
ELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDK
Sbjct: 421 ELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDK 480
Query: 481 IEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL 538
IEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL
Sbjct: 481 IEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL 538
>gi|6912478 karyopherin alpha 6 [Homo sapiens]
Length = 536
Score = 868 bits (2242), Expect = 0.0
Identities = 437/538 (81%), Positives = 480/538 (89%), Gaps = 5/538 (0%)
Query: 1 MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEE 60
M +PGK+N+R+KSYKN +LNP+EMRRRREEEG+QLRKQKRE+QLFKRRNV E EE
Sbjct: 4 MASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNV---ELINEEA 60
Query: 61 VMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDE 120
M D ++ +S+ VIT +M+EM+FS + QL+ TQKFRKLLSKEP+PPIDE
Sbjct: 61 AMFDSLLMDSYVSST--TGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDE 118
Query: 121 VISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSS 180
VI+TP VV RFVEFLKR ENCTLQFE+AW LTNIASG S QT+IVI+AGAVPIFIELL+S
Sbjct: 119 VINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNS 178
Query: 181 EFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLC 240
+FEDVQEQAVWALGNIAGDS++CRDYVL+C+IL PLL L +K RLTMTRNAVWALSNLC
Sbjct: 179 DFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLC 238
Query: 241 RGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRR 300
RGK+PPPEFAKVSPCL VLS LLF SD+D+LADACWALSYLSDGPN+KIQAVID+GVCRR
Sbjct: 239 RGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRR 298
Query: 301 LVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACW 360
LVELLMHNDYKV SPALRAVGNIVTGDDIQTQVILNCSAL LLHLLSSPKESI+KEACW
Sbjct: 299 LVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACW 358
Query: 361 TISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLV 420
TISNITAGNRAQIQ VIDANIFP LI ILQ AEFRTRKEAAWAITNATSGG+ EQI+YLV
Sbjct: 359 TISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLV 418
Query: 421 ELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDK 480
LGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQE KR+G+G+NPYC LIEEAYGLDK
Sbjct: 419 SLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDK 478
Query: 481 IEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL 538
IEFLQSHENQEIYQKAFDLIEHYFG ED+DSS+APQVD QQQ+IFQQ EAPMEGFQL
Sbjct: 479 IEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL 536
>gi|39812229 karyopherin alpha 5 [Homo sapiens]
Length = 539
Score = 865 bits (2234), Expect = 0.0
Identities = 432/539 (80%), Positives = 476/539 (88%), Gaps = 4/539 (0%)
Query: 1 MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEE 60
M +PGK+N+R+KSYKNK+LNP EMRRRREEEG+QLRKQKREEQLFKRRNV + E
Sbjct: 4 MASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRND---E 60
Query: 61 VMSDGGFHEAQISNMEMAPGG-VITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPID 119
M + + IS+ P V+T+DM++MIFS + +QQL+ATQKFRKLLSKEPNPPID
Sbjct: 61 SMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPID 120
Query: 120 EVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLS 179
+VI PGVV RFV+FL+R ENCTLQFE+AW LTNIASG L T++VI+ GAVPIFI+LL+
Sbjct: 121 QVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLN 180
Query: 180 SEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNL 239
SE EDVQEQAVWALGNIAGD+ CRD+VL+C ILPPLL+L + NRLT TRNAVWALSNL
Sbjct: 181 SEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNL 240
Query: 240 CRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCR 299
CRGK+PPP F+KVSPCLNVLS LLF SD DVLAD CWALSYLSDGPNDKIQAVID+GVCR
Sbjct: 241 CRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCR 300
Query: 300 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEAC 359
RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSAL LLHLLSSPKESI+KEAC
Sbjct: 301 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC 360
Query: 360 WTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYL 419
WT+SNITAGNRAQIQ VIDANIFP LI ILQ AEFRTRKEAAWAITNATSGG+ EQI+YL
Sbjct: 361 WTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL 420
Query: 420 VELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLD 479
V LGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQE+K+NG GINPYCALIEEAYGLD
Sbjct: 421 VALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLD 480
Query: 480 KIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL 538
KIEFLQSHENQEIYQKAFDLIEHYFG E++D SI PQVD NQQQ+IFQQ EAPM+GFQL
Sbjct: 481 KIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL 539
>gi|4504901 karyopherin alpha 4 [Homo sapiens]
Length = 521
Score = 462 bits (1190), Expect = e-130
Identities = 251/533 (47%), Positives = 341/533 (63%), Gaps = 22/533 (4%)
Query: 7 ENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGG 66
+N RLK++KNK + + MRR+R E ++LRK KR+E L KRRNV E+ E+ DG
Sbjct: 8 DNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVP--HEDICEDSDIDGD 65
Query: 67 FHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPG 126
+ Q +++E +++ S + QLSA Q RKLLS + NPPID++I + G
Sbjct: 66 YR-VQNTSLEA---------IVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKS-G 114
Query: 127 VVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQ 186
++ V L+R +N +LQFE+AW LTNIASG S QT+ V+Q+ AVP+F+ LL S ++V
Sbjct: 115 ILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVC 174
Query: 187 EQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPP 246
EQAVWALGNI GD CRDYV+ ++ PLL S +T RN W + NLCR K PP
Sbjct: 175 EQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPP 234
Query: 247 PEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLM 306
P + L L L+ +D ++L D WALSYL+D N++IQ VID+G+ LV LL
Sbjct: 235 PPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLS 294
Query: 307 HNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNIT 366
H + KV + ALRAVGNIVTG D QTQV+LNC AL LL+ PKE I KEA W +SNIT
Sbjct: 295 HQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNIT 354
Query: 367 AGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIK 426
AGN+ Q+Q VIDAN+ P +I +L +F T+KEAAWAI+N T G +Q+ YL++ I
Sbjct: 355 AGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIP 414
Query: 427 PLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQS 486
P C+LLTV D+++VQV L+GL NIL++ E EA+ G LIEE GL+KIE LQ+
Sbjct: 415 PFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGN-------LIEECGGLEKIEQLQN 467
Query: 487 HENQEIYQKAFDLIEHYFGTE--DEDSSIAPQVDLNQQQYIFQQCEAPMEGFQ 537
HEN++IY+ A+++I+ +F ++ DED S+ P+ P EGFQ
Sbjct: 468 HENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQ 520
>gi|34485722 karyopherin alpha 3 [Homo sapiens]
Length = 521
Score = 462 bits (1189), Expect = e-130
Identities = 249/515 (48%), Positives = 333/515 (64%), Gaps = 22/515 (4%)
Query: 4 PGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMS 63
P EN R+KS+KNK + + MRR R E ++LRK KR+E L K+RNV E + +V +
Sbjct: 5 PSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDA 64
Query: 64 DGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVIS 123
D +AQ +E +++ S +P QLSA Q RKLLS + NPPID++I
Sbjct: 65 D---FKAQNVTLEA---------ILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIK 112
Query: 124 TPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFE 183
+ G++ V+ L+R +N +LQFE+AW LTNIASG S QT+ V+Q+ AVP+F+ LL S +
Sbjct: 113 S-GILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQ 171
Query: 184 DVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGK 243
+V EQAVWALGNI GD CRDYV+ ++ PLL S +T RN W + NLCR K
Sbjct: 172 NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNK 231
Query: 244 SPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVE 303
PPP V L L L++ +D ++L D WALSYL+DG N++IQ VID+GV LV
Sbjct: 232 DPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVP 291
Query: 304 LLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTIS 363
LL H + KV + ALRAVGNIVTG D QTQV+LNC L +LLS PKE I KEA W +S
Sbjct: 292 LLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLS 351
Query: 364 NITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELG 423
NITAGN+ Q+Q VIDA + P +I L +F T+KEAAWAI+N T G +Q++YLV+
Sbjct: 352 NITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQN 411
Query: 424 CIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEF 483
I P C+LL+V DS++VQV L+GL+NIL + EA + +IEE GL+KIE
Sbjct: 412 VIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEA-------STIAEIIEECGGLEKIEV 464
Query: 484 LQSHENQEIYQKAFDLIEHYFGTE--DEDSSIAPQ 516
LQ HEN++IY+ AF++I+ YF + DED + P+
Sbjct: 465 LQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPE 499
>gi|4504897 karyopherin alpha 2 [Homo sapiens]
Length = 529
Score = 439 bits (1130), Expect = e-123
Identities = 241/523 (46%), Positives = 333/523 (63%), Gaps = 22/523 (4%)
Query: 10 RLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHE 69
RL +KNK + EMRRRR E ++LRK K+++Q+ KRRNV++ ++ + +
Sbjct: 13 RLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENR---- 68
Query: 70 AQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVA 129
+N V D+++ I S + E QL ATQ RKLLS+E PPID +I G++
Sbjct: 69 ---NNQGTVNWSV--DDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRA-GLIP 122
Query: 130 RFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQA 189
+FV FL R + +QFESAW LTNIASG S QT+ V+ GA+P FI LL+S + EQA
Sbjct: 123 KFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQA 182
Query: 190 VWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMT----RNAVWALSNLCRGKSP 245
VWALGNIAGD ++ RD V+ + PLL L + + ++ RN W LSNLCR K+P
Sbjct: 183 VWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNP 242
Query: 246 PPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELL 305
P V L L LL D +VLAD CWA+SYL+DGPN++I V+ GV +LV+LL
Sbjct: 243 APPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLL 302
Query: 306 MHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNI 365
++ +V+PALRA+GNIVTG D QTQV+++ AL LL++PK +I+KEA WT+SNI
Sbjct: 303 GASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNI 362
Query: 366 TAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCI 425
TAG + QIQ V++ + P L+S+L A+F+T+KEA WA+TN TSGG+ EQI YLV G I
Sbjct: 363 TAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGII 422
Query: 426 KPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQ 485
+PL +LLT D+KI+ V L+ + NI + E+ + I +IEE GLDKIE LQ
Sbjct: 423 EPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSI-----MIEECGGLDKIEALQ 477
Query: 486 SHENQEIYQKAFDLIEHYFGT-EDEDSSIAPQVDLNQQQYIFQ 527
+HEN+ +Y+ + LIE YF E+ED ++ P+ + Y FQ
Sbjct: 478 NHENESVYKASLSLIEKYFSVEEEEDQNVVPET--TSEGYTFQ 518
>gi|224589129 karyopherin 7 [Homo sapiens]
Length = 516
Score = 379 bits (972), Expect = e-105
Identities = 220/523 (42%), Positives = 308/523 (58%), Gaps = 19/523 (3%)
Query: 10 RLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHE 69
R + +K + + R++R L+LRK K++EQ KRRN+ + +T E + G
Sbjct: 10 RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKG---- 65
Query: 70 AQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVA 129
+ ++I+ + S P ATQ RK+LS+E NPP+ VI G++
Sbjct: 66 --------VAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEA-GLIP 116
Query: 130 RFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQA 189
R VEFLK LQFE+AW LTNIASG S QTR V++ GA+ IELLSS V EQA
Sbjct: 117 RMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQA 176
Query: 190 VWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEF 249
VWALGNIAGD RD V+ N +P LL L S +T RN W LSNLCR K+P P
Sbjct: 177 VWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCD 236
Query: 250 AKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHND 309
V L L LL D++VL+DACWALSYL+DG N +I V++ GV RLV L+ ++
Sbjct: 237 TAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSE 296
Query: 310 YKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGN 369
V++P+LR VGNIVTG D QTQ+ ++ L L LL K SI+KEA W +SN+ AG
Sbjct: 297 LNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGP 356
Query: 370 RAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLC 429
IQ ++ ++ P L+++L+ EF+ +KEA W + N +G + +Q+ LV G ++PL
Sbjct: 357 CHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLV 416
Query: 430 DLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHEN 489
+LLT D KIV + L+ + IL+ E+ +++ C LIEE G+D+IE LQ HEN
Sbjct: 417 NLLTAPDVKIVLIILDVISCILQAAEKRSEKEN-----LCLLIEELGGIDRIEALQLHEN 471
Query: 490 QEIYQKAFDLIEHYFG-TEDEDSSIAPQVDLNQQQYIFQQCEA 531
++I Q A ++IE +FG EDE ++ QV ++I +C A
Sbjct: 472 RQIGQSALNIIEKHFGEEEDESQTLLSQVIDQDYEFIDYECLA 514
>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
Length = 509
Score = 78.2 bits (191), Expect = 2e-14
Identities = 61/239 (25%), Positives = 110/239 (46%), Gaps = 5/239 (2%)
Query: 168 AGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLT 227
AG + + LL +Q+ A ALG +A + + V+ C+ILP L+ ++QNR
Sbjct: 40 AGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRF- 98
Query: 228 MTRNAVWALSNLCRGKSPPPEFAKVSPC--LNVLSWLLFVSDTDVLADACWALSYLSDGP 285
+ A + L + GK P + C L+ L L D V A WAL Y++
Sbjct: 99 YKKAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHN 156
Query: 286 NDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLH 345
+ QAV+DAG LV + + + A A+ +I Q +++ A+ L
Sbjct: 157 AELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQ 216
Query: 346 LLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAI 404
++ +P +K + +S ++ + + V++A IFP +++ L+ + +K A+ I
Sbjct: 217 MILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLI 275
Score = 62.0 bits (149), Expect = 1e-09
Identities = 51/198 (25%), Positives = 89/198 (44%), Gaps = 7/198 (3%)
Query: 256 LNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDY---KV 312
+++L LL + A AL L++ +D +AV+ + +LV L + K
Sbjct: 43 MSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKA 102
Query: 313 VSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQ 372
+ LRAVG Q I++C AL +L+ L +K+ A W + I N
Sbjct: 103 AAFVLRAVGK---HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAEL 159
Query: 373 IQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLL 432
Q V+DA P L+ +Q E ++ AA A+++ S E + +V+ G + L ++
Sbjct: 160 SQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK-HSPELAQTVVDAGAVAHLAQMI 218
Query: 433 TVMDSKIVQVALNGLENI 450
D+K+ L+ L +
Sbjct: 219 LNPDAKLKHQILSALSQV 236
Score = 57.4 bits (137), Expect = 3e-08
Identities = 53/248 (21%), Positives = 101/248 (40%), Gaps = 2/248 (0%)
Query: 147 SAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDY 206
+AW L IA N+ ++ V+ AGAVP+ + + ++ A AL +IA S
Sbjct: 145 AAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
Query: 207 VLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVS 266
V+D + L Q+ + + + ALS + + E + V+ L
Sbjct: 205 VVDAGAVAHLAQMILNPDA-KLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDK 263
Query: 267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVT- 325
D V +A + ++ + Q V++AG +++ + P + +G +
Sbjct: 264 DEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAH 323
Query: 326 GDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPAL 385
+++ VI++ Q + L P++ IK A W + I + V N P L
Sbjct: 324 SENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVL 383
Query: 386 ISILQTAE 393
+S+ + E
Sbjct: 384 LSLYMSTE 391
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/301 (19%), Positives = 119/301 (39%), Gaps = 2/301 (0%)
Query: 97 EQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIAS 156
+ Q + TQ + + P E + GV++ + L T+Q +A L +A+
Sbjct: 12 QYQKARTQFVQMVAELATRPQNIETLQNAGVMS-LLRTLLLDVVPTIQQTAALALGRLAN 70
Query: 157 GNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPL 216
N V++ +P + L+ + ++ A + L + S ++DC L L
Sbjct: 71 YNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTL 130
Query: 217 LQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACW 276
+ + + A WAL + R + + + + +L + + + A
Sbjct: 131 VICLEDFDP-GVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAAS 189
Query: 277 ALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILN 336
ALS ++ + Q V+DAG L +++++ D K+ L A+ + ++++
Sbjct: 190 ALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVE 249
Query: 337 CSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRT 396
+L L E +KK A I I Q V++A A+I + + + T
Sbjct: 250 AEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNT 309
Query: 397 R 397
R
Sbjct: 310 R 310
Score = 47.4 bits (111), Expect = 3e-05
Identities = 34/164 (20%), Positives = 74/164 (45%), Gaps = 1/164 (0%)
Query: 289 IQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLS 348
I+ + +AGV L LL+ + A A+G + +D + ++ C L L++ L+
Sbjct: 34 IETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLA 93
Query: 349 SPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNAT 408
KK A + + + + Q ++D L+ L+ + ++ AAWA+
Sbjct: 94 EQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWAL-RYI 152
Query: 409 SGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILR 452
+ +AE + +V+ G + L + + + ++A + L +I +
Sbjct: 153 ARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK 196
>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
Length = 458
Score = 78.2 bits (191), Expect = 2e-14
Identities = 61/239 (25%), Positives = 110/239 (46%), Gaps = 5/239 (2%)
Query: 168 AGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLT 227
AG + + LL +Q+ A ALG +A + + V+ C+ILP L+ ++QNR
Sbjct: 40 AGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRF- 98
Query: 228 MTRNAVWALSNLCRGKSPPPEFAKVSPC--LNVLSWLLFVSDTDVLADACWALSYLSDGP 285
+ A + L + GK P + C L+ L L D V A WAL Y++
Sbjct: 99 YKKAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHN 156
Query: 286 NDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLH 345
+ QAV+DAG LV + + + A A+ +I Q +++ A+ L
Sbjct: 157 AELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQ 216
Query: 346 LLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAI 404
++ +P +K + +S ++ + + V++A IFP +++ L+ + +K A+ I
Sbjct: 217 MILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLI 275
Score = 62.0 bits (149), Expect = 1e-09
Identities = 51/198 (25%), Positives = 89/198 (44%), Gaps = 7/198 (3%)
Query: 256 LNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDY---KV 312
+++L LL + A AL L++ +D +AV+ + +LV L + K
Sbjct: 43 MSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKA 102
Query: 313 VSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQ 372
+ LRAVG Q I++C AL +L+ L +K+ A W + I N
Sbjct: 103 AAFVLRAVGK---HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAEL 159
Query: 373 IQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLL 432
Q V+DA P L+ +Q E ++ AA A+++ S E + +V+ G + L ++
Sbjct: 160 SQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK-HSPELAQTVVDAGAVAHLAQMI 218
Query: 433 TVMDSKIVQVALNGLENI 450
D+K+ L+ L +
Sbjct: 219 LNPDAKLKHQILSALSQV 236
Score = 57.4 bits (137), Expect = 3e-08
Identities = 53/248 (21%), Positives = 101/248 (40%), Gaps = 2/248 (0%)
Query: 147 SAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDY 206
+AW L IA N+ ++ V+ AGAVP+ + + ++ A AL +IA S
Sbjct: 145 AAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
Query: 207 VLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVS 266
V+D + L Q+ + + + ALS + + E + V+ L
Sbjct: 205 VVDAGAVAHLAQMILNPDA-KLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDK 263
Query: 267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVT- 325
D V +A + ++ + Q V++AG +++ + P + +G +
Sbjct: 264 DEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAH 323
Query: 326 GDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPAL 385
+++ VI++ Q + L P++ IK A W + I + V N P L
Sbjct: 324 SENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVL 383
Query: 386 ISILQTAE 393
+S+ + E
Sbjct: 384 LSLYMSTE 391
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/301 (19%), Positives = 119/301 (39%), Gaps = 2/301 (0%)
Query: 97 EQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIAS 156
+ Q + TQ + + P E + GV++ + L T+Q +A L +A+
Sbjct: 12 QYQKARTQFVQMVAELATRPQNIETLQNAGVMS-LLRTLLLDVVPTIQQTAALALGRLAN 70
Query: 157 GNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPL 216
N V++ +P + L+ + ++ A + L + S ++DC L L
Sbjct: 71 YNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTL 130
Query: 217 LQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACW 276
+ + + A WAL + R + + + + +L + + + A
Sbjct: 131 VICLEDFDP-GVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAAS 189
Query: 277 ALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILN 336
ALS ++ + Q V+DAG L +++++ D K+ L A+ + ++++
Sbjct: 190 ALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVE 249
Query: 337 CSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRT 396
+L L E +KK A I I Q V++A A+I + + + T
Sbjct: 250 AEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNT 309
Query: 397 R 397
R
Sbjct: 310 R 310
Score = 47.4 bits (111), Expect = 3e-05
Identities = 34/164 (20%), Positives = 74/164 (45%), Gaps = 1/164 (0%)
Query: 289 IQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLS 348
I+ + +AGV L LL+ + A A+G + +D + ++ C L L++ L+
Sbjct: 34 IETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLA 93
Query: 349 SPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNAT 408
KK A + + + + Q ++D L+ L+ + ++ AAWA+
Sbjct: 94 EQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWAL-RYI 152
Query: 409 SGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILR 452
+ +AE + +V+ G + L + + + ++A + L +I +
Sbjct: 153 ARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK 196
>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
[Homo sapiens]
Length = 558
Score = 57.0 bits (136), Expect = 4e-08
Identities = 62/288 (21%), Positives = 122/288 (42%), Gaps = 21/288 (7%)
Query: 115 NPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIF 174
N E I G++ F L + +C + + ++ +A ++ V AG +
Sbjct: 38 NTETSEKIQASGILQLFASLLTPQSSCKAKVAN--IIAEVAKNEFMRIPCV-DAGLISPL 94
Query: 175 IELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQ-NRLTMTRNAV 233
++LL+S+ ++V Q ALGNI DS + +++ ++P L++L +T +
Sbjct: 95 VQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCL 154
Query: 234 WALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVI 293
A NL +S +FA + ++ + D L+ L++ K+Q ++
Sbjct: 155 VAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQ-LV 213
Query: 294 DAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSL---------- 343
+AG+ L+E++ KV S + + TG D+ ++L ++Q L
Sbjct: 214 EAGLVECLLEIVQQ---KVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQ 270
Query: 344 --LHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISIL 389
L + S ++ I+N A N A ++D I L+ +L
Sbjct: 271 RVLSWIPSNNHQLQLAGALAIANF-ARNDANCIHMVDNGIVEKLMDLL 317
>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
[Homo sapiens]
Length = 559
Score = 57.0 bits (136), Expect = 4e-08
Identities = 62/288 (21%), Positives = 122/288 (42%), Gaps = 21/288 (7%)
Query: 115 NPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIF 174
N E I G++ F L + +C + + ++ +A ++ V AG +
Sbjct: 39 NTETSEKIQASGILQLFASLLTPQSSCKAKVAN--IIAEVAKNEFMRIPCV-DAGLISPL 95
Query: 175 IELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQ-NRLTMTRNAV 233
++LL+S+ ++V Q ALGNI DS + +++ ++P L++L +T +
Sbjct: 96 VQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCL 155
Query: 234 WALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVI 293
A NL +S +FA + ++ + D L+ L++ K+Q ++
Sbjct: 156 VAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQ-LV 214
Query: 294 DAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSL---------- 343
+AG+ L+E++ KV S + + TG D+ ++L ++Q L
Sbjct: 215 EAGLVECLLEIVQQ---KVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQ 271
Query: 344 --LHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISIL 389
L + S ++ I+N A N A ++D I L+ +L
Sbjct: 272 RVLSWIPSNNHQLQLAGALAIANF-ARNDANCIHMVDNGIVEKLMDLL 318
>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
Length = 872
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/311 (21%), Positives = 128/311 (41%), Gaps = 15/311 (4%)
Query: 167 QAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRL 226
+ A+P ++LL SE+ +Q A+ LG IA D R + D L L+++ +
Sbjct: 189 ELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKE-SRTMLRDNQGLDHLIKILETKELN 247
Query: 227 TMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPN 286
+ A+ ++N + + +LS+ + D+ +A A++ + P
Sbjct: 248 DLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPE 307
Query: 287 DKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHL 346
++ + + V + LV LL + A +A+ + ++ ++ N + L+ L
Sbjct: 308 NR-KLFHEQEVEKCLVALLGSENDGTKIAASQAISAMC--ENSGSKDFFNNQGIPQLIQL 364
Query: 347 LSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITN 406
L S E +++ A ++N+T N A +A+ LI++L + AA +TN
Sbjct: 365 LKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTN 424
Query: 407 ATSGGSAEQIKYLVE-----LGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRN 461
E ++ ++ I PL TV+ SK AL + + RN
Sbjct: 425 M---AMQEPLRLNIQNHDIMHAIISPLRSANTVVQSK---AALAVTATACDVEARTELRN 478
Query: 462 GTGINPYCALI 472
G+ P L+
Sbjct: 479 SGGLEPLVELL 489
Score = 45.1 bits (105), Expect = 2e-04
Identities = 56/252 (22%), Positives = 113/252 (44%), Gaps = 20/252 (7%)
Query: 267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTG 326
+ ++LA AC A+ + + +++ G L +LL H D V A G + +
Sbjct: 38 EEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASN 97
Query: 327 DDIQTQVILNCSALQSLLHLLSSPKESIKKE-ACWTISNITAGNRAQIQTVIDANIFPAL 385
+D++ +++ + S++ L+ +E + E A ++N++A +++Q + P L
Sbjct: 98 NDVK-KLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEP-L 155
Query: 386 ISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALN 445
I +L + + +K + I N L EL I P+ DLL I +AL
Sbjct: 156 IRLLSSPDPDVKKNSMECIYNLVQDFQCR--AKLQELNAIPPILDLLKSEYPVIQLLALK 213
Query: 446 GLENILRLGEQEAKRNGTGINPYCALIEEAYGLDK-IEFLQSHENQEIYQKAFDLIEHYF 504
L I ++E++ ++ + GLD I+ L++ E +++ +A +I +
Sbjct: 214 TLGVI--ANDKESR----------TMLRDNQGLDHLIKILETKELNDLHIEALAVIANCL 261
Query: 505 GTEDEDSSIAPQ 516
ED D+ + Q
Sbjct: 262 --EDMDTMVQIQ 271
Score = 34.7 bits (78), Expect = 0.23
Identities = 24/77 (31%), Positives = 40/77 (51%), Gaps = 5/77 (6%)
Query: 137 RKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNI 196
R N +Q ++A +T A +T + G P+ +ELL S+ ++V++ A WA+
Sbjct: 449 RSANTVVQSKAALAVTATACDVEARTELRNSGGLEPL-VELLRSKNDEVRKHASWAVMVC 507
Query: 197 AGD----STMCRDYVLD 209
AGD + +CR LD
Sbjct: 508 AGDELTANELCRLGALD 524
Score = 34.3 bits (77), Expect = 0.30
Identities = 42/173 (24%), Positives = 79/173 (45%), Gaps = 4/173 (2%)
Query: 171 VPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTR 230
+P I+LL S+ E+V+E A AL N+ + + + + + PL+ L S + R
Sbjct: 358 IPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSK-RDGAIA 416
Query: 231 NAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQ 290
NA L+N+ + P + ++ + L ++T V + A A++ + + +
Sbjct: 417 NAATVLTNMAM-QEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEARTE 475
Query: 291 AVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSL 343
+ ++G LVELL + +V A AV + GD++ + AL L
Sbjct: 476 -LRNSGGLEPLVELLRSKNDEVRKHASWAV-MVCAGDELTANELCRLGALDIL 526
>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
Length = 493
Score = 49.7 bits (117), Expect = 7e-06
Identities = 86/395 (21%), Positives = 145/395 (36%), Gaps = 47/395 (11%)
Query: 22 DEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQISN-MEMAPG 80
+E+RRRR E LRK +RE+QL +R + E E E ++ + A
Sbjct: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQR 76
Query: 81 GVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKEN 140
G + + S Q TQ+ I G + V L +
Sbjct: 77 GTEEKEREGALVSLRRGLQHPETQQ--------------TFIRLEGSMRTLVGLLTSNQ- 121
Query: 141 CTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDS 200
LQ E+A L + S + T A + LSS D E ++ LGN+ +S
Sbjct: 122 ALLQLEAARCLHEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVES 180
Query: 201 TMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLS 260
R +L I+P L + + + +ALS L + + P + +
Sbjct: 181 EAVRRQLLPQGIVPALAACIQSPH-VAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQ 239
Query: 261 WLLFV------SDTDVLADACWALSYL--SDGPNDKIQAVIDAGVCRRLVELLMHNDYKV 312
+L + + V + W L Y+ S N +I G L LL+ V
Sbjct: 240 HMLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSN---PLLIGHGALSTLGLLLLDLAGAV 296
Query: 313 -----------VSPALRAVGNIVT-------GDDIQTQVILNCSALQSLLHLLSSPKESI 354
P LR + N++T G +Q + +AL LL + S+
Sbjct: 297 QKTEDAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSL 356
Query: 355 KKEACWTISNITAGNRAQIQTVIDANIFPALISIL 389
E W ++N+TA + + +++ ++ L+ +L
Sbjct: 357 LPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLL 391
Score = 37.0 bits (84), Expect = 0.046
Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 8/128 (6%)
Query: 157 GNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPL 216
G +Q R A+ I ++ + + + +W L N+ +S +L +++ PL
Sbjct: 328 GGQMQLRDERVVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPL 387
Query: 217 LQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAK---VSPCLNVLSWLLFVSDTDVLAD 273
LQL N + +V L+ LC P + + P L L L SDT+V+
Sbjct: 388 LQLLPVSNVV-----SVMVLTVLCNVAEKGPAYCQRLWPGPLLPALLHTLAFSDTEVVGQ 442
Query: 274 ACWALSYL 281
+ L L
Sbjct: 443 SLELLHLL 450
>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
Length = 1363
Score = 47.0 bits (110), Expect = 4e-05
Identities = 54/280 (19%), Positives = 122/280 (43%), Gaps = 18/280 (6%)
Query: 115 NPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIF 174
N I + I+ G + V K K+ ++Q + A + ++AS N+L + ++
Sbjct: 825 NKEIQDAIAMEGAIPPLVALFKGKQ-ISVQMKGAMAVESLASHNALIQKAFLEKSLTKYL 883
Query: 175 IELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLD-------CNIL---PPLLQLFSKQN 224
++LL + DV+EQ AL +AG + + Y+ + N+L +Q +
Sbjct: 884 LKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEA 943
Query: 225 RLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDG 284
+ +++++ + +C G P + ++ ++ +S + C +++ S+
Sbjct: 944 VIALSKDSRMHQNQICEGNGIAPLVRLLR--ISTIAEGTLLSVIRAVGSICIGVAHTSNP 1001
Query: 285 PNDKIQAVIDAGVCRRLVELLM-HNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQ-- 341
+ Q V+D L++LL H + ++ IV G+D+ + + +
Sbjct: 1002 VSQ--QFVVDENAFPVLIQLLRNHPSPNIKVEVAFSLACIVLGNDVLQKDLHENEGFEYA 1059
Query: 342 SLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANI 381
+L+LL S ++ I A + ++ NR Q ++++ I
Sbjct: 1060 DVLYLLHSTEKDICLRAGYALTLFAFNNRFQQYLILESGI 1099
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/164 (21%), Positives = 77/164 (46%), Gaps = 5/164 (3%)
Query: 297 VCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKK 356
V + LVE+L YK A+ ++ I +D + IL+ + +L++LL S K ++
Sbjct: 630 VWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQC 689
Query: 357 EACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQI 416
+ +SNI+ +++ + +++A P+LI++L E A + + E
Sbjct: 690 KTVGLLSNIST-HKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI---AQCENK 745
Query: 417 KYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKR 460
+ + I L +LL + ++ +N + +L +G + +R
Sbjct: 746 DVIAKYNGIPSLINLLNLNIENVLVNVMNCI-RVLCIGNENNQR 788
Score = 37.4 bits (85), Expect = 0.035
Identities = 57/263 (21%), Positives = 104/263 (39%), Gaps = 51/263 (19%)
Query: 157 GNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPL 216
GN R V + +P I LSS+ + ++ + A+ + D+ +D + +PPL
Sbjct: 782 GNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPL 841
Query: 217 LQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVL---AD 273
+ LF K ++++ A+ +L + + L LL DV A
Sbjct: 842 VALF-KGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAV 900
Query: 274 ACWALS--------YLSD------------GPNDKIQAVIDAGVCRRLVELLMHNDY--- 310
A WAL+ Y+++ P+ K+Q V V + MH +
Sbjct: 901 ALWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICE 960
Query: 311 -KVVSP-----------------ALRAVGNIV-----TGDDIQTQVILNCSALQSLLHLL 347
++P +RAVG+I T + + Q +++ +A L+ LL
Sbjct: 961 GNGIAPLVRLLRISTIAEGTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLL 1020
Query: 348 -SSPKESIKKEACWTISNITAGN 369
+ P +IK E ++++ I GN
Sbjct: 1021 RNHPSPNIKVEVAFSLACIVLGN 1043
>gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6
[Homo sapiens]
Length = 516
Score = 45.8 bits (107), Expect = 1e-04
Identities = 30/109 (27%), Positives = 52/109 (47%), Gaps = 3/109 (2%)
Query: 115 NPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIF 174
N E I G++ F L + +C + + ++ +A ++ V AG +
Sbjct: 39 NTETSEKIQASGILQLFASLLTPQSSCKAKVAN--IIAEVAKNEFMRIPCV-DAGLISPL 95
Query: 175 IELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQ 223
++LL+S+ ++V Q ALGNI DS ++ NI L++LF KQ
Sbjct: 96 VQLLNSKDQEVLLQTGRALGNICYDSQSSKEQFASTNIAEELVKLFKKQ 144
Score = 39.7 bits (91), Expect = 0.007
Identities = 26/98 (26%), Positives = 46/98 (46%)
Query: 293 IDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKE 352
+DAG+ LV+LL D +V+ RA+GNI + + + + L+ L E
Sbjct: 87 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSQSSKEQFASTNIAEELVKLFKKQIE 146
Query: 353 SIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQ 390
K+E + + A N A +++A + L+ I+Q
Sbjct: 147 HDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQ 184
>gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens]
Length = 385
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/279 (22%), Positives = 107/279 (38%), Gaps = 54/279 (19%)
Query: 151 LTNIASGNSLQTRIVIQAGAVPIFIELLSSEFE--DVQEQAVWALGNIAGDSTMCRDYVL 208
+ N GN+ Q +I GAVP + LL E +++ + LG++A + +L
Sbjct: 29 MKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLL 88
Query: 209 DCNILPPLLQ-LFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSD 267
DC+I+P LLQ L S P+ + CL L +F S
Sbjct: 89 DCHIIPALLQGLLS-------------------------PDLKFIEACLRCLR-TIFTSP 122
Query: 268 TDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGD 327
P + + DA V L+ LL + Y + + G
Sbjct: 123 VT---------------PEELLYT--DATVIPHLMALLSRSRY-TQEYICQIFSHCCKGP 164
Query: 328 DIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALIS 387
D QT ++ N A+Q++ HLL+S ++ +A S + N T+++ + L+
Sbjct: 165 DHQT-ILFNHGAVQNIAHLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLP 223
Query: 388 ILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIK 426
+ + K +T SA+ + Y+ G I+
Sbjct: 224 QIFVKMLQRDKPIEMQLT------SAKCLTYMCRAGAIR 256
>gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens]
Length = 385
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/279 (22%), Positives = 107/279 (38%), Gaps = 54/279 (19%)
Query: 151 LTNIASGNSLQTRIVIQAGAVPIFIELLSSEFE--DVQEQAVWALGNIAGDSTMCRDYVL 208
+ N GN+ Q +I GAVP + LL E +++ + LG++A + +L
Sbjct: 29 MKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLL 88
Query: 209 DCNILPPLLQ-LFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSD 267
DC+I+P LLQ L S P+ + CL L +F S
Sbjct: 89 DCHIIPALLQGLLS-------------------------PDLKFIEACLRCLR-TIFTSP 122
Query: 268 TDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGD 327
P + + DA V L+ LL + Y + + G
Sbjct: 123 VT---------------PEELLYT--DATVIPHLMALLSRSRY-TQEYICQIFSHCCKGP 164
Query: 328 DIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALIS 387
D QT ++ N A+Q++ HLL+S ++ +A S + N T+++ + L+
Sbjct: 165 DHQT-ILFNHGAVQNIAHLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLP 223
Query: 388 ILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIK 426
+ + K +T SA+ + Y+ G I+
Sbjct: 224 QIFVKMLQRDKPIEMQLT------SAKCLTYMCRAGAIR 256
>gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]
Length = 659
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/279 (22%), Positives = 107/279 (38%), Gaps = 54/279 (19%)
Query: 151 LTNIASGNSLQTRIVIQAGAVPIFIELLSSEFE--DVQEQAVWALGNIAGDSTMCRDYVL 208
+ N GN+ Q +I GAVP + LL E +++ + LG++A + +L
Sbjct: 29 MKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLL 88
Query: 209 DCNILPPLLQ-LFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSD 267
DC+I+P LLQ L S P+ + CL L +F S
Sbjct: 89 DCHIIPALLQGLLS-------------------------PDLKFIEACLRCLR-TIFTSP 122
Query: 268 TDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGD 327
P + + DA V L+ LL + Y + + G
Sbjct: 123 VT---------------PEELLYT--DATVIPHLMALLSRSRY-TQEYICQIFSHCCKGP 164
Query: 328 DIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALIS 387
D QT ++ N A+Q++ HLL+S ++ +A S + N T+++ + L+
Sbjct: 165 DHQT-ILFNHGAVQNIAHLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLP 223
Query: 388 ILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIK 426
+ + K +T SA+ + Y+ G I+
Sbjct: 224 QIFVKMLQRDKPIEMQLT------SAKCLTYMCRAGAIR 256
Score = 30.0 bits (66), Expect = 5.6
Identities = 44/217 (20%), Positives = 91/217 (41%), Gaps = 20/217 (9%)
Query: 150 VLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLD 209
+L N+ S ++++GAV + L SE ++ +WAL N+A + + +
Sbjct: 435 MLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQA----EQKIK 490
Query: 210 CNILPPLL--QLFS--KQNRLTMTRNAVWALSNLCRGKSPPPEFAKV-----SPCLNVLS 260
+IL L QLF + L + + L NL S P K+ + ++
Sbjct: 491 ADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLL---STRPHIDKIMSTHGKQIMQAVT 547
Query: 261 WLL-FVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRA 319
+L + +V L+ ++DG K + + + +++ + H+ K+ A+
Sbjct: 548 LILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFC 607
Query: 320 VGNIVTGDD---IQTQVILNCSALQSLLHLLSSPKES 353
+ N++ ++ + Q L + +LH LS +S
Sbjct: 608 ISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDS 644
>gi|211059433 coiled-coil domain containing 79 [Homo sapiens]
Length = 727
Score = 37.4 bits (85), Expect = 0.035
Identities = 33/134 (24%), Positives = 61/134 (45%), Gaps = 4/134 (2%)
Query: 132 VEFLK-RKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELL--SSEFEDVQEQ 188
+E LK + +N Q E+ + +I NS + + G + +F++ L SSE V+E
Sbjct: 20 LECLKYQMDNAFSQKEALVTIHSICQQNSNASVYFREIGGL-MFVKNLAKSSEHSMVKEA 78
Query: 189 AVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPE 248
A++ LG IA + C+ + + L S + + + R +V+ + L
Sbjct: 79 ALYTLGAIAEKNVYCQQTLCTSELFEDLTWFLSNDSNINLKRMSVYVILVLVSNNRTGQT 138
Query: 249 FAKVSPCLNVLSWL 262
+ + C+ VLS L
Sbjct: 139 LVRETGCITVLSRL 152
>gi|53829376 plakophilin 4 isoform b [Homo sapiens]
Length = 1149
Score = 36.2 bits (82), Expect = 0.078
Identities = 37/128 (28%), Positives = 53/128 (41%), Gaps = 6/128 (4%)
Query: 246 PPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELL 305
P EFA P L + +L V A+A L +L G N V G + LV+LL
Sbjct: 520 PREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLL 579
Query: 306 MHNDYKVVSPALRAVGNIVTGDDIQTQVIL--NCSALQSLLHLLSSPKESIKKE----AC 359
H +V A A+ N+V G I N + +LL LL ++ +E
Sbjct: 580 DHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVL 639
Query: 360 WTISNITA 367
W +S+ A
Sbjct: 640 WNLSSCDA 647
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/94 (29%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Query: 110 LSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGN----SLQTRIV 165
LSK P E++ P VV ++ L N SA L N+++GN + V
Sbjct: 811 LSKSPKGV--EMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAV 868
Query: 166 IQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGD 199
+ +PI +ELL + + V AL N+A D
Sbjct: 869 RKEKGLPILVELLRMDNDRVVSSVATALRNMALD 902
Score = 31.2 bits (69), Expect = 2.5
Identities = 19/92 (20%), Positives = 40/92 (43%), Gaps = 2/92 (2%)
Query: 301 LVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACW 360
++ +L H V + A + ++ GD+ + ++ L+ LL ++K AC
Sbjct: 533 VIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACG 592
Query: 361 TISNITAGNRAQIQTVIDANI--FPALISILQ 390
+ N+ G + N+ PAL+ +L+
Sbjct: 593 ALRNLVFGKSTDENKIAMKNVGGIPALLRLLR 624
>gi|53829374 plakophilin 4 isoform a [Homo sapiens]
Length = 1192
Score = 36.2 bits (82), Expect = 0.078
Identities = 37/128 (28%), Positives = 53/128 (41%), Gaps = 6/128 (4%)
Query: 246 PPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELL 305
P EFA P L + +L V A+A L +L G N V G + LV+LL
Sbjct: 520 PREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLL 579
Query: 306 MHNDYKVVSPALRAVGNIVTGDDIQTQVIL--NCSALQSLLHLLSSPKESIKKE----AC 359
H +V A A+ N+V G I N + +LL LL ++ +E
Sbjct: 580 DHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVL 639
Query: 360 WTISNITA 367
W +S+ A
Sbjct: 640 WNLSSCDA 647
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/94 (29%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Query: 110 LSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGN----SLQTRIV 165
LSK P E++ P VV ++ L N SA L N+++GN + V
Sbjct: 811 LSKSPKGV--EMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAV 868
Query: 166 IQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGD 199
+ +PI +ELL + + V AL N+A D
Sbjct: 869 RKEKGLPILVELLRMDNDRVVSSVATALRNMALD 902
Score = 31.2 bits (69), Expect = 2.5
Identities = 19/92 (20%), Positives = 40/92 (43%), Gaps = 2/92 (2%)
Query: 301 LVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACW 360
++ +L H V + A + ++ GD+ + ++ L+ LL ++K AC
Sbjct: 533 VIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACG 592
Query: 361 TISNITAGNRAQIQTVIDANI--FPALISILQ 390
+ N+ G + N+ PAL+ +L+
Sbjct: 593 ALRNLVFGKSTDENKIAMKNVGGIPALLRLLR 624
>gi|4504811 junction plakoglobin [Homo sapiens]
Length = 745
Score = 36.2 bits (82), Expect = 0.078
Identities = 68/328 (20%), Positives = 128/328 (39%), Gaps = 49/328 (14%)
Query: 86 DMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQF 145
++ +++ + P A +L KE + ++ +P +VA V ++ +
Sbjct: 146 ELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRA--LMGSPQLVAAVVRTMQNTSDLDTAR 203
Query: 146 ESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRD 205
+ +L N+ S + + ++G +P + +LSS E V A+ L N+ +
Sbjct: 204 CTTSILHNL-SHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKM 262
Query: 206 YVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFV 265
V + L ++ L +K N P A + CL +L++
Sbjct: 263 AVRLADGLQKMVPLLNKNN---------------------PKFLAITTDCLQLLAYGNQE 301
Query: 266 SDTDVLADA-----------------CWA----LSYLSDGPNDKIQAVIDAGVCRRLVEL 304
S +LA+ W L LS P++K A+++AG + L +
Sbjct: 302 SKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK-PAIVEAGGMQALGKH 360
Query: 305 LMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISN 364
L N ++V L + N+ D+ T+ S L+ L++ LS ++ A T+SN
Sbjct: 361 LTSNSPRLVQNCLWTLRNL---SDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417
Query: 365 ITAGNRAQIQTVIDANIFPALISILQTA 392
+T N V + ALI + A
Sbjct: 418 LTCNNSKNKTLVTQNSGVEALIHAILRA 445
Score = 32.3 bits (72), Expect = 1.1
Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 165 VIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQN 224
+ + +P+F++LL S E++Q A L +A D D + PL++L +N
Sbjct: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKE-AADAIDAEGASAPLMELLHSRN 638
Query: 225 RLTMTRNAVWALSNLCRGKSP 245
T T A L + K+P
Sbjct: 639 EGTATYAAA-VLFRISEDKNP 658
>gi|12056468 junction plakoglobin [Homo sapiens]
Length = 745
Score = 36.2 bits (82), Expect = 0.078
Identities = 68/328 (20%), Positives = 128/328 (39%), Gaps = 49/328 (14%)
Query: 86 DMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQF 145
++ +++ + P A +L KE + ++ +P +VA V ++ +
Sbjct: 146 ELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRA--LMGSPQLVAAVVRTMQNTSDLDTAR 203
Query: 146 ESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRD 205
+ +L N+ S + + ++G +P + +LSS E V A+ L N+ +
Sbjct: 204 CTTSILHNL-SHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKM 262
Query: 206 YVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFV 265
V + L ++ L +K N P A + CL +L++
Sbjct: 263 AVRLADGLQKMVPLLNKNN---------------------PKFLAITTDCLQLLAYGNQE 301
Query: 266 SDTDVLADA-----------------CWA----LSYLSDGPNDKIQAVIDAGVCRRLVEL 304
S +LA+ W L LS P++K A+++AG + L +
Sbjct: 302 SKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK-PAIVEAGGMQALGKH 360
Query: 305 LMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISN 364
L N ++V L + N+ D+ T+ S L+ L++ LS ++ A T+SN
Sbjct: 361 LTSNSPRLVQNCLWTLRNL---SDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417
Query: 365 ITAGNRAQIQTVIDANIFPALISILQTA 392
+T N V + ALI + A
Sbjct: 418 LTCNNSKNKTLVTQNSGVEALIHAILRA 445
Score = 32.3 bits (72), Expect = 1.1
Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 165 VIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQN 224
+ + +P+F++LL S E++Q A L +A D D + PL++L +N
Sbjct: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKE-AADAIDAEGASAPLMELLHSRN 638
Query: 225 RLTMTRNAVWALSNLCRGKSP 245
T T A L + K+P
Sbjct: 639 EGTATYAAA-VLFRISEDKNP 658
>gi|24308089 chromodomain helicase DNA binding protein 5 [Homo
sapiens]
Length = 1954
Score = 36.2 bits (82), Expect = 0.078
Identities = 32/138 (23%), Positives = 64/138 (46%), Gaps = 13/138 (9%)
Query: 5 GKENFRLKSYKNKSLNPDEMRRRREEEGLQL---RKQKREEQLFKRRNVATAEEETEEEV 61
GK + S S N +++ + E EG +K+K++ + K + +++ +E+
Sbjct: 63 GKRKKKEGSNDELSENEEDLEEKSESEGSDYSPNKKKKKKLKDKKEKKAKRKKKDEDEDD 122
Query: 62 MSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLL-----SKEPNP 116
DG E + S MA G+ D ++ +FS+ L+ + F + L K P
Sbjct: 123 NDDGCLKEPKSSGQLMAEWGL---DDVDYLFSEEDYHTLTNYKAFSQFLRPLIAKKNPKI 179
Query: 117 PIDEVISTPGVVARFVEF 134
P+ ++++ G A++ EF
Sbjct: 180 PMSKMMTVLG--AKWREF 195
>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
Length = 1044
Score = 35.0 bits (79), Expect = 0.17
Identities = 29/107 (27%), Positives = 53/107 (49%), Gaps = 2/107 (1%)
Query: 291 AVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSP 350
A+ D G L+ LL ++ K +L+ + I I+ Q I++ L ++++L SP
Sbjct: 489 AIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIR-QNIVDLGGLPIMVNILDSP 547
Query: 351 KESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTR 397
+S+K A TI+N+ RA+ + V L+++L A T+
Sbjct: 548 HKSLKCLAAETIANVAKFKRAR-RVVRQHGGITKLVALLDCAHDSTK 593
Score = 29.6 bits (65), Expect = 7.3
Identities = 45/200 (22%), Positives = 75/200 (37%), Gaps = 52/200 (26%)
Query: 169 GAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTM 228
G + + + LL S+ ++V A+ NIA D V+ + + PLL + N +
Sbjct: 881 GGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLA--VITDHGVVPLLSKLANTNNNKL 938
Query: 229 TRNAVWALSNLC---RGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGP 285
+ A+S C R + E V+P + L +DT+V AL LS+
Sbjct: 939 RHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLK----SNDTNVHRATAQALYQLSE-- 992
Query: 286 NDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLH 345
DA C + MH + A++ LL
Sbjct: 993 --------DADNC-----ITMHEN----------------------------GAVKLLLD 1011
Query: 346 LLSSPKESIKKEACWTISNI 365
++ SP + +++ A ISNI
Sbjct: 1012 MVGSPDQDLQEAAAGCISNI 1031
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 34.3 bits (77), Expect = 0.30
Identities = 18/61 (29%), Positives = 33/61 (54%)
Query: 6 KENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDG 65
KE + K K K+ ++ + + EEE + RK+K++++ +R EEE +EE +
Sbjct: 34 KEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEE 93
Query: 66 G 66
G
Sbjct: 94 G 94
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 34.3 bits (77), Expect = 0.30
Identities = 28/101 (27%), Positives = 43/101 (42%), Gaps = 10/101 (9%)
Query: 22 DEMRRRREEEGLQLRKQKREEQL--------FKRRNVATAEEETEEEVMSDGGFHEAQIS 73
D R+ REEE QLR+++ E+QL F+ +E E + M D Q
Sbjct: 1552 DRDRKFREEE--QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG 1609
Query: 74 NMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEP 114
++ E + + EQQL ++ RK L +EP
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEP 1650
Score = 33.5 bits (75), Expect = 0.50
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 17/103 (16%)
Query: 11 LKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEA 70
L+ + + L+ E R+ EE QLR+Q+RE+QL R+ E EE+++ +G E
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE---EEQLLQEG--EEQ 1682
Query: 71 QISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKE 113
Q+ E + F + EQQL ++ RK L +E
Sbjct: 1683 QLRRQER-----------DRKF-REEEQQLRRQERERKFLQEE 1713
Score = 32.0 bits (71), Expect = 1.5
Identities = 14/42 (33%), Positives = 26/42 (61%)
Query: 17 KSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETE 58
+ L E+RR R+EE Q ++ +RE+QL +++ E++ E
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Score = 32.0 bits (71), Expect = 1.5
Identities = 27/110 (24%), Positives = 51/110 (46%), Gaps = 16/110 (14%)
Query: 15 KNKSLNPDEMRRRREEEGL-------QLRKQKREEQLFKRRNVATAEEETEEEVMSDGGF 67
+ + L D R+ REEE L QLR+Q+R+ + F+ +E E + + +
Sbjct: 1657 REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK-FREEEQQLRRQERERKFLQE--- 1712
Query: 68 HEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPP 117
E Q+ E+ E + ++ ++QL +++RK+L +E P
Sbjct: 1713 -EQQLRRQELER----KFREEEQLRQETEQEQLRRQERYRKILEEEQLRP 1757
Score = 30.4 bits (67), Expect = 4.3
Identities = 18/70 (25%), Positives = 35/70 (50%), Gaps = 2/70 (2%)
Query: 4 PGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEE--TEEEV 61
PG+ + + + + L E + ++E Q +Q+R+E+L+++R EE EEE
Sbjct: 133 PGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQ 192
Query: 62 MSDGGFHEAQ 71
+ HE +
Sbjct: 193 LQSCKGHETE 202
Score = 30.4 bits (67), Expect = 4.3
Identities = 15/54 (27%), Positives = 30/54 (55%)
Query: 11 LKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSD 64
LKS + + ++RR ++E Q K++ EE+ ++R EEE E+ +++
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687
Score = 30.0 bits (66), Expect = 5.6
Identities = 16/35 (45%), Positives = 24/35 (68%), Gaps = 3/35 (8%)
Query: 26 RRREEEGLQLRKQKREEQLFKRRNVATAEEETEEE 60
R+ EEE Q R+QKR+EQ R +A EE++E++
Sbjct: 127 RQLEEEPGQRRRQKRQEQ---ERELAEGEEQSEKQ 158
Score = 30.0 bits (66), Expect = 5.6
Identities = 17/54 (31%), Positives = 28/54 (51%)
Query: 6 KENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEE 59
+E R + + + E R +REEE +L ++ + E +RR AEEE E+
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Score = 30.0 bits (66), Expect = 5.6
Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 17/114 (14%)
Query: 4 PGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMS 63
P + R + ++ + L E R+ EE +LR+Q+RE + K +E E+++
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER-EQQLRQ 1410
Query: 64 DGG----FHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKE 113
D E Q+S E + F + EQQ+ ++ RK L +E
Sbjct: 1411 DRDRKFREEEQQLSRQER-----------DRKF-REEEQQVRRQERERKFLEEE 1452
Score = 29.6 bits (65), Expect = 7.3
Identities = 21/64 (32%), Positives = 33/64 (51%), Gaps = 9/64 (14%)
Query: 6 KENFRLKSYKNKSLNPDEMRRRREEEGLQLRK----QKREEQLF-----KRRNVATAEEE 56
+E +L+ + + L + +RRR+E Q RK Q++EEQL KRR ++
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 57 TEEE 60
EEE
Sbjct: 991 REEE 994
Score = 29.3 bits (64), Expect = 9.5
Identities = 16/55 (29%), Positives = 27/55 (49%)
Query: 6 KENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEE 60
+E R + K + +R R E+ L+ +++R EQL KR E+E E+
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ 565
Score = 29.3 bits (64), Expect = 9.5
Identities = 19/67 (28%), Positives = 33/67 (49%), Gaps = 3/67 (4%)
Query: 6 KENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETE-EEVMSD 64
+E R + K L +++R REE+ QLR+Q+R+ + + + EE + SD
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPEREEQ--QLRRQERDRKFREEEQLRQEREEQQLRSQESD 1794
Query: 65 GGFHEAQ 71
F E +
Sbjct: 1795 RKFREEE 1801
>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
tract binding protein associated) [Homo sapiens]
Length = 707
Score = 34.3 bits (77), Expect = 0.30
Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 11/76 (14%)
Query: 8 NFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGF 67
N ++ K L +E RRRREE + +R+++ EEQ+ ++R EE S G+
Sbjct: 554 NQEMQKRKEMQLRQEEERRRREE-EMMIRQREMEEQMRRQR----------EESYSRMGY 602
Query: 68 HEAQISNMEMAPGGVI 83
+ + +M M GG +
Sbjct: 603 MDPRERDMRMGGGGAM 618
>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
[Homo sapiens]
Length = 607
Score = 33.9 bits (76), Expect = 0.39
Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 7/104 (6%)
Query: 293 IDAGVCRRLVELLMHNDYKVVSPALRAVGNIV-------TGDDIQTQVILNCSALQSLLH 345
+DAG+ LV+LL D +V+ RA+GNI + D + L+SL
Sbjct: 86 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 145
Query: 346 LLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISIL 389
+ E + C + N + N + +I+ + P L+ +L
Sbjct: 146 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLL 189
>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
[Homo sapiens]
Length = 607
Score = 33.9 bits (76), Expect = 0.39
Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 7/104 (6%)
Query: 293 IDAGVCRRLVELLMHNDYKVVSPALRAVGNIV-------TGDDIQTQVILNCSALQSLLH 345
+DAG+ LV+LL D +V+ RA+GNI + D + L+SL
Sbjct: 87 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 146
Query: 346 LLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISIL 389
+ E + C + N + N + +I+ + P L+ +L
Sbjct: 147 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLL 190
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,026,935
Number of Sequences: 37866
Number of extensions: 861977
Number of successful extensions: 4888
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 4056
Number of HSP's gapped (non-prelim): 670
length of query: 538
length of database: 18,247,518
effective HSP length: 107
effective length of query: 431
effective length of database: 14,195,856
effective search space: 6118413936
effective search space used: 6118413936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.