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Search of human proteins with 221307580
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens]
(400 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens] 795 0.0
gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens] 788 0.0
gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens] 778 0.0
gi|197304744 RUN domain containing 3B isoform b [Homo sapiens] 405 e-113
gi|19923090 RUN domain containing 3B isoform a [Homo sapiens] 394 e-110
gi|197304746 RUN domain containing 3B isoform c [Homo sapiens] 368 e-102
gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo sa... 113 3e-25
gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo sapi... 113 3e-25
gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo sap... 113 3e-25
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 108 1e-23
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 105 6e-23
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 105 6e-23
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 102 6e-22
gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo sa... 69 6e-12
gi|116292170 RUN domain containing 2A [Homo sapiens] 49 1e-05
gi|221139728 pleckstrin homology domain containing, family M (wi... 47 4e-05
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 43 6e-04
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 41 0.002
gi|48762942 huntingtin interacting protein-1-related [Homo sapiens] 39 0.011
gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] 39 0.011
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 38 0.014
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 37 0.041
gi|32698688 citron [Homo sapiens] 36 0.054
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 36 0.070
gi|21735548 centrosomal protein 2 [Homo sapiens] 35 0.092
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 35 0.12
gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo s... 35 0.12
gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo s... 35 0.12
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 35 0.12
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 35 0.16
>gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens]
Length = 400
Score = 795 bits (2052), Expect = 0.0
Identities = 400/400 (100%), Positives = 400/400 (100%)
Query: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN
Sbjct: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
Query: 61 FAAILEQILSHRFKGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKG 120
FAAILEQILSHRFKGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKG
Sbjct: 61 FAAILEQILSHRFKGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKG 120
Query: 121 RAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFC 180
RAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFC
Sbjct: 121 RAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFC 180
Query: 181 LKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDED 240
LKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDED
Sbjct: 181 LKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDED 240
Query: 241 SWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKR 300
SWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKR
Sbjct: 241 SWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKR 300
Query: 301 ELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRH 360
ELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRH
Sbjct: 301 ELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRH 360
Query: 361 SFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGSSEPN 400
SFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGSSEPN
Sbjct: 361 SFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGSSEPN 400
>gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens]
Length = 405
Score = 788 bits (2036), Expect = 0.0
Identities = 400/405 (98%), Positives = 400/405 (98%), Gaps = 5/405 (1%)
Query: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN
Sbjct: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
Query: 61 FAAILEQILSHRFK-----GPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 115
FAAILEQILSHRFK GPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST
Sbjct: 61 FAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 120
Query: 116 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 175
ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI
Sbjct: 121 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 180
Query: 176 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL 235
DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL
Sbjct: 181 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL 240
Query: 236 VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN 295
VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN
Sbjct: 241 VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN 300
Query: 296 QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK 355
QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK
Sbjct: 301 QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK 360
Query: 356 LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGSSEPN 400
LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGSSEPN
Sbjct: 361 LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGSSEPN 405
>gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens]
Length = 446
Score = 778 bits (2010), Expect = 0.0
Identities = 395/400 (98%), Positives = 395/400 (98%), Gaps = 5/400 (1%)
Query: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN
Sbjct: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
Query: 61 FAAILEQILSHRFK-----GPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 115
FAAILEQILSHRFK GPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST
Sbjct: 61 FAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 120
Query: 116 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 175
ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI
Sbjct: 121 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 180
Query: 176 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL 235
DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL
Sbjct: 181 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL 240
Query: 236 VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN 295
VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN
Sbjct: 241 VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN 300
Query: 296 QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK 355
QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK
Sbjct: 301 QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK 360
Query: 356 LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIG 395
LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIG
Sbjct: 361 LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIG 400
>gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
Length = 456
Score = 405 bits (1040), Expect = e-113
Identities = 215/388 (55%), Positives = 281/388 (72%), Gaps = 17/388 (4%)
Query: 13 GLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHR 72
G K S+RN AVER+NLITVCRFSVKTL+++ E IDDSS EF NFAAILEQILSHR
Sbjct: 18 GGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHR 77
Query: 73 FKGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKR 132
KG V+WF + R FWDYIR+AC KV NC+ SIENMEN+S++RAKGRAWIRVALMEK
Sbjct: 78 LKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKH 137
Query: 133 MSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPV 192
+SEYI+TALRD +TTRRFY+ GAI+L +EA +L GML+GL+AIDFSFCLKGE LDG P
Sbjct: 138 LSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPA 197
Query: 193 VIDYTPYLKFTQSYDYL-TDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQ 251
VIDYTPYLK+ QS D + +DEEE + SS SE ++PE+ P + DE+SW++K +++Q
Sbjct: 198 VIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQ 257
Query: 252 KFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQE 311
K+++ QKGYLEEL+RLRE+QL + ++N+ L ++E++ ++ EK +LE +I+ELQ+
Sbjct: 258 KYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQD 317
Query: 312 QLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRH-------SFMS 364
QLT L +D + +ELT L NQWPS G L+ A ++ LYR+H S+ S
Sbjct: 318 QLTVLKNND----LRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYEKSYQS 373
Query: 365 TEPLSAEASLSSDS-----QRLGEGTRD 387
+ LSAE SLS S + G+G +D
Sbjct: 374 LDQLSAEVSLSQTSLDPGQSQEGDGKQD 401
>gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]
Length = 473
Score = 394 bits (1012), Expect = e-110
Identities = 215/405 (53%), Positives = 281/405 (69%), Gaps = 34/405 (8%)
Query: 13 GLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHR 72
G K S+RN AVER+NLITVCRFSVKTL+++ E IDDSS EF NFAAILEQILSHR
Sbjct: 18 GGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHR 77
Query: 73 FK-----------------GPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 115
K G V+WF + R FWDYIR+AC KV NC+ SIENMEN+S+
Sbjct: 78 LKEISQSCRWLAHLQIPLQGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSS 137
Query: 116 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 175
+RAKGRAWIRVALMEK +SEYI+TALRD +TTRRFY+ GAI+L +EA +L GML+GL+AI
Sbjct: 138 SRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAI 197
Query: 176 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYL-TDEEERHSAESSTSEDNSPEHPYLP 234
DFSFCLKGE LDG P VIDYTPYLK+ QS D + +DEEE + SS SE ++PE+ P
Sbjct: 198 DFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPP 257
Query: 235 LVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQ 294
+ DE+SW++K +++QK+++ QKGYLEEL+RLRE+QL + ++N+ L ++E++
Sbjct: 258 FLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLA 317
Query: 295 NQREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNS 354
++ EK +LE +I+ELQ+QLT L +D + +ELT L NQWPS G L+ A ++
Sbjct: 318 HKLEKEQLEYIIVELQDQLTVLKNND----LRSRQELTAHLTNQWPSPGALDVNAVALDT 373
Query: 355 KLYRRH-------SFMSTEPLSAEASLSSDS-----QRLGEGTRD 387
LYR+H S+ S + LSAE SLS S + G+G +D
Sbjct: 374 LLYRKHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQD 418
>gi|197304746 RUN domain containing 3B isoform c [Homo sapiens]
Length = 407
Score = 368 bits (944), Expect = e-102
Identities = 183/302 (60%), Positives = 237/302 (78%), Gaps = 1/302 (0%)
Query: 13 GLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHR 72
G K S+RN AVER+NLITVCRFSVKTL+++ E IDDSS EF NFAAILEQILSHR
Sbjct: 18 GGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHR 77
Query: 73 FKGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKR 132
KG V+WF + R FWDYIR+AC KV NC+ SIENMEN+S++RAKGRAWIRVALMEK
Sbjct: 78 LKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKH 137
Query: 133 MSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPV 192
+SEYI+TALRD +TTRRFY+ GAI+L +EA +L GML+GL+AIDFSFCLKGE LDG P
Sbjct: 138 LSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPA 197
Query: 193 VIDYTPYLKFTQSYDYL-TDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQ 251
VIDYTPYLK+ QS D + +DEEE + SS SE ++PE+ P + DE+SW++K +++Q
Sbjct: 198 VIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQ 257
Query: 252 KFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQE 311
K+++ QKGYLEEL+RLRE+QL + ++N+ L ++E++ ++ EK +LE +I+ELQ+
Sbjct: 258 KYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQD 317
Query: 312 QL 313
QL
Sbjct: 318 QL 319
>gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 113 bits (283), Expect = 3e-25
Identities = 83/307 (27%), Positives = 139/307 (45%), Gaps = 57/307 (18%)
Query: 15 SSKKASSRNVAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHR 72
S K + +A ER NL+ + + S+K L+E +D F ++E L H
Sbjct: 116 SGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHG 175
Query: 73 FKGPVSWFSSDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALME 130
K ++ + + FW + L VP +S++++ + T +GRAW+R+ALM+
Sbjct: 176 LKAKKTFLGQN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQ 233
Query: 131 KRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKT 190
K++SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD +
Sbjct: 234 KKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQV 293
Query: 191 PVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKME 250
VID++ YLK D SK + +
Sbjct: 294 G-VIDFSMYLK--------------------------------------DGNSSKGTEGD 314
Query: 251 QKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVI 306
+ + QK Y+EEL R + + +L+A+ L+ EE A N R I
Sbjct: 315 GQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------I 366
Query: 307 LELQEQL 313
+ LQE++
Sbjct: 367 ITLQEEM 373
>gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo
sapiens]
Length = 469
Score = 113 bits (282), Expect = 3e-25
Identities = 81/298 (27%), Positives = 136/298 (45%), Gaps = 57/298 (19%)
Query: 24 VAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKGPVSWFS 81
+A ER NL+ + + S+K L+E +D F ++E L H K ++
Sbjct: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
Query: 82 SDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITT 139
+ + FW + L VP +S++++ + T +GRAW+R+ALM+K++SEY+
Sbjct: 125 QN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKA 182
Query: 140 ALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPY 199
+ FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD + VID++ Y
Sbjct: 183 LINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVG-VIDFSMY 241
Query: 200 LKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQ 259
LK D SK + + + + Q
Sbjct: 242 LK--------------------------------------DGNSSKGTEGDGQITAILDQ 263
Query: 260 KGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVILELQEQL 313
K Y+EEL R + + +L+A+ L+ EE A N R I+ LQE++
Sbjct: 264 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------IITLQEEM 313
>gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 620
Score = 113 bits (282), Expect = 3e-25
Identities = 81/298 (27%), Positives = 136/298 (45%), Gaps = 57/298 (19%)
Query: 24 VAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKGPVSWFS 81
+A ER NL+ + + S+K L+E +D F ++E L H K ++
Sbjct: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
Query: 82 SDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITT 139
+ + FW + L VP +S++++ + T +GRAW+R+ALM+K++SEY+
Sbjct: 125 QN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKA 182
Query: 140 ALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPY 199
+ FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD + VID++ Y
Sbjct: 183 LINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVG-VIDFSMY 241
Query: 200 LKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQ 259
LK D SK + + + + Q
Sbjct: 242 LK--------------------------------------DGNSSKGTEGDGQITAILDQ 263
Query: 260 KGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVILELQEQL 313
K Y+EEL R + + +L+A+ L+ EE A N R I+ LQE++
Sbjct: 264 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------IITLQEEM 313
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 108 bits (269), Expect = 1e-23
Identities = 83/323 (25%), Positives = 146/323 (45%), Gaps = 58/323 (17%)
Query: 15 SSKKASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHR 72
+++ AS + ER NL+ + + S+K LL+ + +D F ++E L H
Sbjct: 100 TARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHG 159
Query: 73 FKGPVSWFSSDGQRGFWDYIRLACSKVP--NNCVSSIENMENISTARAKGRAWIRVALME 130
K S+ + + F+ + L P ++ +S+ N+ + TA +GRAW+ +ALM+
Sbjct: 160 LKVKKSFIGQN--KSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQ 217
Query: 131 KRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKT 190
K++++Y+ + + FY+ A+M+ +E ++ G+L+GL+ +D + CLKGE LD +
Sbjct: 218 KKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQV 277
Query: 191 PVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKME 250
VID++ YLK Q D EH + V D
Sbjct: 278 G-VIDFSLYLKDVQDL------------------DGGKEHERITDVLD------------ 306
Query: 251 QKFRIVYAQKGYLEELVRL-------RESQLKDLEAENRRLQLQLEEAA------AQNQR 297
QK Y+EEL R ++++ LE N +LQ +L A + Q+
Sbjct: 307 --------QKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQ 358
Query: 298 EKRELEGVILELQEQLTGLIPSD 320
+ RE +I E E+ + D
Sbjct: 359 QLREQNELIRERSEKSVEITKQD 381
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 105 bits (263), Expect = 6e-23
Identities = 81/311 (26%), Positives = 140/311 (45%), Gaps = 58/311 (18%)
Query: 27 ERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKGPVSWFSSDG 84
ER NL+ + + S+K LL+ + +D F ++E L H K S+ +
Sbjct: 4 ERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQN- 62
Query: 85 QRGFWDYIRLACSKVP--NNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALR 142
+ F+ + L P ++ +S+ N+ + TA +GRAW+ +ALM+K++++Y+ +
Sbjct: 63 -KSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLID 121
Query: 143 DTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKF 202
+ FY+ A+M+ +E ++ G+L+GL+ +D + CLKGE LD + VID++ YLK
Sbjct: 122 NKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVG-VIDFSLYLKD 180
Query: 203 TQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGY 262
Q D EH + V D QK Y
Sbjct: 181 VQDL------------------DGGKEHERITDVLD--------------------QKNY 202
Query: 263 LEELVRL-------RESQLKDLEAENRRLQLQLEEAA------AQNQREKRELEGVILEL 309
+EEL R ++++ LE N +LQ +L A + Q++ RE +I E
Sbjct: 203 VEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRER 262
Query: 310 QEQLTGLIPSD 320
E+ + D
Sbjct: 263 SEKSVEITKQD 273
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 105 bits (263), Expect = 6e-23
Identities = 81/311 (26%), Positives = 140/311 (45%), Gaps = 58/311 (18%)
Query: 27 ERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKGPVSWFSSDG 84
ER NL+ + + S+K LL+ + +D F ++E L H K S+ +
Sbjct: 4 ERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQN- 62
Query: 85 QRGFWDYIRLACSKVP--NNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALR 142
+ F+ + L P ++ +S+ N+ + TA +GRAW+ +ALM+K++++Y+ +
Sbjct: 63 -KSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLID 121
Query: 143 DTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKF 202
+ FY+ A+M+ +E ++ G+L+GL+ +D + CLKGE LD + VID++ YLK
Sbjct: 122 NKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVG-VIDFSLYLKD 180
Query: 203 TQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGY 262
Q D EH + V D QK Y
Sbjct: 181 VQDL------------------DGGKEHERITDVLD--------------------QKNY 202
Query: 263 LEELVRL-------RESQLKDLEAENRRLQLQLEEAA------AQNQREKRELEGVILEL 309
+EEL R ++++ LE N +LQ +L A + Q++ RE +I E
Sbjct: 203 VEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRER 262
Query: 310 QEQLTGLIPSD 320
E+ + D
Sbjct: 263 SEKSVEITKQD 273
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 102 bits (254), Expect = 6e-22
Identities = 72/271 (26%), Positives = 134/271 (49%), Gaps = 17/271 (6%)
Query: 19 ASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKGP 76
A+ AVER NL+ + + S+K L+E + +D F ++E L H K
Sbjct: 37 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVR 96
Query: 77 VSWFSSDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRMS 134
S+ S + + W + L P +S+ ++ + T + RAW+R+ALM+K+M+
Sbjct: 97 KSFLSYN--KTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMA 154
Query: 135 EYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVI 194
+Y+ + FY+ A+M+ +E ++ G+L+GL+ ID + C+KGE LD + VI
Sbjct: 155 DYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVG-VI 213
Query: 195 DYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFR 254
D++ YLK + + + ++E + + N E L + S +S+ +E+
Sbjct: 214 DFSMYLK---NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEK--- 267
Query: 255 IVYAQKGYLEELVRLRESQLKDLEAENRRLQ 285
+ +EEL + + +K L+ EN +L+
Sbjct: 268 ---SNTKLIEELAIAKNNIIK-LQEENHQLR 294
>gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo
sapiens]
Length = 403
Score = 69.3 bits (168), Expect = 6e-12
Identities = 64/269 (23%), Positives = 115/269 (42%), Gaps = 47/269 (17%)
Query: 19 ASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKGP 76
A+ AVER NL+ + + S+K L+E + +D F ++E L H K
Sbjct: 2 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVR 61
Query: 77 VSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEY 136
S+ S + + W + L P +E
Sbjct: 62 KSFLSYN--KTIWGPLELVEKLYPE--------------------------------AEE 87
Query: 137 ITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDY 196
I ++RD FY+ A+M+ +E ++ G+L+GL+ ID + C+KGE LD + VID+
Sbjct: 88 IGASVRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVG-VIDF 146
Query: 197 TPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIV 256
+ YLK + + + ++E + + N E L + S +S+ +E+
Sbjct: 147 SMYLK---NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEK----- 198
Query: 257 YAQKGYLEELVRLRESQLKDLEAENRRLQ 285
+ +EEL + + +K L+ EN +L+
Sbjct: 199 -SNTKLIEELAIAKNNIIK-LQEENHQLR 225
>gi|116292170 RUN domain containing 2A [Homo sapiens]
Length = 375
Score = 48.5 bits (114), Expect = 1e-05
Identities = 48/178 (26%), Positives = 83/178 (46%), Gaps = 17/178 (9%)
Query: 88 FWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTT 147
FW Y++ +K + + ++ +I++ +GRAW+R AL E + Y+ L D
Sbjct: 86 FWYYVKEVLNK---HELQRFYSLRHIASDVGRGRAWLRCALNEHSLERYLHMLLADRCRL 142
Query: 148 RRFYDSGAIMLRDE-ATILTGMLIGLSAIDFSFCLKGEVLDGKT---PVVID-------- 195
FY+ + ++ +E +++L M GL++I F+ + + L+G++ P V D
Sbjct: 143 STFYEDWSFVMDEERSSMLPTMAAGLNSILFAINIDNKDLNGQSKFAPTVSDLLKESTQN 202
Query: 196 YTPYLK-FTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQK 252
T LK TQ L E SA S + P LP+V+ S +K K +K
Sbjct: 203 VTSLLKESTQGVSSLFREITASSAVSILIKPEQETDP-LPVVSRNVSADAKCKKERKK 259
>gi|221139728 pleckstrin homology domain containing, family M (with
RUN domain) member 2 [Homo sapiens]
Length = 1019
Score = 46.6 bits (109), Expect = 4e-05
Identities = 42/179 (23%), Positives = 73/179 (40%), Gaps = 15/179 (8%)
Query: 38 SVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKGPVSWFSSDGQRGFWDYIRLACS 97
SVK L + A +D N +L+++ H + + D G+W L
Sbjct: 17 SVKKLQSYFAA--CEDEIPAIRNHDKVLQRLCEH-LDHALLYGLQDLSSGYWV---LVVH 70
Query: 98 KVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIM 157
+ IE +++++T + RAW+ +AL E + Y+ + ++Y A++
Sbjct: 71 FTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALV 130
Query: 158 L-RDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEER 215
D T+ ++ GL I F LD P +D PY+ YL D E+R
Sbjct: 131 CSHDHLTLFLTLVSGLEFIRFE-------LDLDAP-YLDLAPYMPDYYKPQYLLDFEDR 181
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 42.7 bits (99), Expect = 6e-04
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 2/75 (2%)
Query: 107 IENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIM-LRDEATIL 165
I+NM I T + RAWIR++L +K +S+++ L + T++ Y A + +E
Sbjct: 853 IQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQF 912
Query: 166 TGMLIGLSAIDFSFC 180
L+ L+A+D+ FC
Sbjct: 913 LYHLLSLNAVDY-FC 926
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/75 (30%), Positives = 40/75 (53%), Gaps = 2/75 (2%)
Query: 107 IENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIM-LRDEATIL 165
I+N+ I T K RAW+R+++ +K +S ++ L D T++ Y A + DE
Sbjct: 871 IQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQF 930
Query: 166 TGMLIGLSAIDFSFC 180
L+ +A+D+ FC
Sbjct: 931 LYHLLSFNAVDY-FC 944
>gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]
Length = 1068
Score = 38.5 bits (88), Expect = 0.011
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 264 EELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHAP 323
EE+ R++E +E R +L+LEE + Q ++ KRELE EL L ++
Sbjct: 483 EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE--- 539
Query: 324 LAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQR 380
Q EL++ L L+GA + L S + EA+LS + QR
Sbjct: 540 --QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVR----ETEAALSREQQR 590
Score = 30.4 bits (67), Expect = 3.0
Identities = 18/69 (26%), Positives = 34/69 (49%)
Query: 248 KMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVIL 307
++ + + A+K L VR RE+ L ++ R + L ++ +E+ EL+G +
Sbjct: 544 ELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA 603
Query: 308 ELQEQLTGL 316
E + Q GL
Sbjct: 604 ERESQEQGL 612
>gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]
Length = 1048
Score = 38.5 bits (88), Expect = 0.011
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 264 EELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHAP 323
EE+ R++E +E R +L+LEE + Q ++ KRELE EL L ++
Sbjct: 463 EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE--- 519
Query: 324 LAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQR 380
Q EL++ L L+GA + L S + EA+LS + QR
Sbjct: 520 --QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVR----ETEAALSREQQR 570
Score = 30.4 bits (67), Expect = 3.0
Identities = 18/69 (26%), Positives = 34/69 (49%)
Query: 248 KMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVIL 307
++ + + A+K L VR RE+ L ++ R + L ++ +E+ EL+G +
Sbjct: 524 ELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA 583
Query: 308 ELQEQLTGL 316
E + Q GL
Sbjct: 584 ERESQEQGL 592
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 38.1 bits (87), Expect = 0.014
Identities = 28/87 (32%), Positives = 43/87 (49%), Gaps = 2/87 (2%)
Query: 264 EELVR-LRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHA 322
E+L R + E Q DLE E +L+++E A++++E E + I L E+ + SD A
Sbjct: 925 EQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASL-EETNRTLTSDVA 983
Query: 323 PLAQGSKELTTPLVNQWPSLGTLNGAE 349
LA +EL L + L L E
Sbjct: 984 NLANEKEELNNKLKDVQEQLSRLKDEE 1010
Score = 32.0 bits (71), Expect = 1.0
Identities = 14/47 (29%), Positives = 30/47 (63%)
Query: 267 VRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQL 313
+++ E QLK +++ LE+ A+ ++E+++ +G + ELQ+QL
Sbjct: 820 LKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQL 866
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 36.6 bits (83), Expect = 0.041
Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 24/137 (17%)
Query: 180 CLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTD- 238
CLK LD +P +Y L + +DEEER + E + P+ P L+ +
Sbjct: 535 CLK---LDETSPRGEEYQDKLAAEEGTS--SDEEER--TKVLLKEGSDPQPPLGSLLKEK 587
Query: 239 -------EDSWYSKWHKMEQKFR-----IVYAQKGYLEELVRLRESQLKDLEAENRRLQL 286
E+ W S+ K++ + + Y E+L L+ QL DLE E +LQ
Sbjct: 588 TSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALK--QLSDLERE--KLQR 643
Query: 287 QLEEAAAQNQREKRELE 303
+L+E QN K +LE
Sbjct: 644 ELQETTQQNHAMKAQLE 660
Score = 33.5 bits (75), Expect = 0.35
Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 219 ESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDL- 277
+ T ++ S E Y+ +ED K E+K + LE+LV+ ++K +
Sbjct: 388 DMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVR 447
Query: 278 ---EAENRRLQ----LQLEEAAAQNQREKRELE 303
EAE ++LQ QLEE ++++E ++LE
Sbjct: 448 SSVEAERKKLQREVEAQLEEVRKKSEKEIKQLE 480
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 36.2 bits (82), Expect = 0.054
Identities = 38/125 (30%), Positives = 59/125 (47%), Gaps = 12/125 (9%)
Query: 254 RIVYAQKGYLEELVRLR---ESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQ 310
R + AQ+ + EL + + E+Q LEA+NR+L+ QLE+ + Q+ +K L LEL+
Sbjct: 800 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRL----LELE 855
Query: 311 EQLTGLI---PSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEP 367
+L + L + EL L + L L A A S+L R + E
Sbjct: 856 TRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQL--RQAKTELEE 913
Query: 368 LSAEA 372
+AEA
Sbjct: 914 TTAEA 918
Score = 33.1 bits (74), Expect = 0.46
Identities = 25/111 (22%), Positives = 49/111 (44%)
Query: 202 FTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKG 261
++++ L E S S ++ +S E L + K HKMEQ+ ++ +
Sbjct: 421 YSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVS 480
Query: 262 YLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQ 312
+E ++ +E +LK E + L+ L + KR LE +E+ ++
Sbjct: 481 EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQE 531
Score = 29.6 bits (65), Expect = 5.0
Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 15/81 (18%)
Query: 250 EQKFRIVYAQKGYLEELVRLRESQLK-----DLEAENRRLQLQ--LEEAAAQNQREKREL 302
+QKF + Q G LE R E QL+ D +NR L+L+ L E + +++ +K EL
Sbjct: 814 QQKFYLE-TQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLEL 872
Query: 303 EGVILELQ-------EQLTGL 316
+ + ELQ QLT L
Sbjct: 873 KRQLTELQLSLQERESQLTAL 893
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 35.8 bits (81), Expect = 0.070
Identities = 39/142 (27%), Positives = 64/142 (45%), Gaps = 19/142 (13%)
Query: 260 KGYLEELV-RLRESQLKDLE--AENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGL 316
+G EEL+ RL+E+Q ++ ++ R L QLEEA A +RELE + L Q+T L
Sbjct: 516 QGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAA----QRELEAQVSSLSRQVTQL 571
Query: 317 IPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAE---------GASNSKLYRRHSFMSTEP 367
L + S+ T ++ +G G A +L + HS +
Sbjct: 572 QGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGK 631
Query: 368 LSAEASLSSDSQRLGEGTRDEE 389
A L +++RL +R++E
Sbjct: 632 EEALCQLQEENRRL---SREQE 650
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 35.4 bits (80), Expect = 0.092
Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 5/88 (5%)
Query: 234 PLVT--DEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEE- 290
PL+T ++ S HK+ Q + L + V+ E +L D EAE ++ +L++
Sbjct: 1231 PLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDL 1290
Query: 291 --AAAQNQREKRELEGVILELQEQLTGL 316
+QNQ EK + EG L+ +L L
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMEL 1318
Score = 32.3 bits (72), Expect = 0.78
Identities = 21/72 (29%), Positives = 42/72 (58%), Gaps = 7/72 (9%)
Query: 248 KMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEE-AAAQNQREKR------ 300
+++++ + V +Q+ +EEL R +E +DLE ++ L LQ E ++QR ++
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE 1683
Query: 301 ELEGVILELQEQ 312
+LE + L L+E+
Sbjct: 1684 DLEQIKLSLRER 1695
Score = 29.6 bits (65), Expect = 5.0
Identities = 20/64 (31%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 249 MEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILE 308
+EQ + + G L++ ++L E RR+Q LEE + E RE E +L
Sbjct: 1847 LEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQA-LEEVLGDLRAESREQEKALLA 1905
Query: 309 LQEQ 312
LQ+Q
Sbjct: 1906 LQQQ 1909
Score = 29.3 bits (64), Expect = 6.6
Identities = 28/129 (21%), Positives = 52/129 (40%), Gaps = 11/129 (8%)
Query: 201 KFTQSYDYLTDEEERHSAE-SSTSEDNSPEHPYLPLVT--------DEDSWYSKWHKMEQ 251
K Q+ D L D+ ++ + T + S H L + ++ W K + +E
Sbjct: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLES 1313
Query: 252 KFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQE 311
+ ++ L+ RLR ++L+ +EA+ R LQ + Q E + V Q
Sbjct: 1314 ELMELHETMASLQS--RLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
Query: 312 QLTGLIPSD 320
G++ D
Sbjct: 1372 SAAGILEED 1380
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 35.0 bits (79), Expect = 0.12
Identities = 45/189 (23%), Positives = 76/189 (40%), Gaps = 9/189 (4%)
Query: 201 KFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQK 260
K+ +S L E + A S ++E ++ Y + +++ + ++++ + Q
Sbjct: 1459 KYEESQSEL--ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 261 GYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSD 320
G + + E K LEAE LQ LEEA A + E EG IL Q + +
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE----EGKILRAQLEFNQIKAEI 1572
Query: 321 HAPLAQGSKELTTPLVNQW---PSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSD 377
LA+ +E+ N SL T AE S ++ R M + E LS
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632
Query: 378 SQRLGEGTR 386
++ E +
Sbjct: 1633 NRMAAEAQK 1641
>gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo
sapiens]
Length = 638
Score = 35.0 bits (79), Expect = 0.12
Identities = 28/106 (26%), Positives = 52/106 (49%), Gaps = 10/106 (9%)
Query: 213 EERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRES 272
E++ + +E +S + L L+ D+D + ++ Q+ + AQ EL + ES
Sbjct: 269 EQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASELSKSMES 325
Query: 273 -------QLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQE 311
QL+ EAEN RL +Q++ + K E+E ++ +L+E
Sbjct: 326 MRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 371
>gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo
sapiens]
Length = 805
Score = 35.0 bits (79), Expect = 0.12
Identities = 28/106 (26%), Positives = 52/106 (49%), Gaps = 10/106 (9%)
Query: 213 EERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRES 272
E++ + +E +S + L L+ D+D + ++ Q+ + AQ EL + ES
Sbjct: 264 EQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASELSKSMES 320
Query: 273 -------QLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQE 311
QL+ EAEN RL +Q++ + K E+E ++ +L+E
Sbjct: 321 MRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 366
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 35.0 bits (79), Expect = 0.12
Identities = 22/54 (40%), Positives = 32/54 (59%), Gaps = 4/54 (7%)
Query: 263 LEELVRLRESQLKDLEAENRRLQLQL----EEAAAQNQREKRELEGVILELQEQ 312
L+ L R +E+ ++LEAE +LQ QL EE A+ + EK EL I LQ++
Sbjct: 995 LQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE 1048
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 34.7 bits (78), Expect = 0.16
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 8/107 (7%)
Query: 211 DEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKF----RIVYAQKGYLEEL 266
D E A+ +S+ P LP ED ++E+K ++ + Y +
Sbjct: 3317 DRERELHAQLQSSDGTGQSRPPLP---SEDLLKELQKQLEEKHSRIVELLNETEKYKLDS 3373
Query: 267 VRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQL 313
++ R+ KD + + LQ + +EA + Q++ EL+ + +LQ QL
Sbjct: 3374 LQTRQQMEKDRQVHRKTLQTE-QEANTEGQKKMHELQSKVEDLQRQL 3419
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,954,719
Number of Sequences: 37866
Number of extensions: 606761
Number of successful extensions: 3799
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 3049
Number of HSP's gapped (non-prelim): 888
length of query: 400
length of database: 18,247,518
effective HSP length: 104
effective length of query: 296
effective length of database: 14,309,454
effective search space: 4235598384
effective search space used: 4235598384
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.