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Search of human proteins with 221219026
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221219026 pleckstrin homology-like domain, family B, member
1 isoform b [Homo sapiens]
(1319 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221219026 pleckstrin homology-like domain, family B, member 1... 2598 0.0
gi|221219024 pleckstrin homology-like domain, family B, member 1... 2568 0.0
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 2568 0.0
gi|197313728 pleckstrin homology-like domain, family B, member 2... 657 0.0
gi|21955172 pleckstrin homology-like domain, family B, member 2 ... 657 0.0
gi|197313732 pleckstrin homology-like domain, family B, member 2... 637 0.0
gi|197313730 pleckstrin homology-like domain, family B, member 2... 637 0.0
gi|157266264 pleckstrin homology-like domain, family B, member 3... 250 7e-66
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens] 100 2e-20
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 80 2e-14
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 80 2e-14
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 77 1e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 76 2e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 76 2e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 76 2e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 76 2e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 76 2e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 76 2e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 76 2e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 76 2e-13
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens] 76 2e-13
gi|148746195 trichohyalin [Homo sapiens] 76 2e-13
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 73 2e-12
gi|21735548 centrosomal protein 2 [Homo sapiens] 72 3e-12
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 72 4e-12
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 72 4e-12
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 72 4e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 72 5e-12
gi|163965366 nascent polypeptide-associated complex alpha subuni... 72 5e-12
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 71 8e-12
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 2598 bits (6735), Expect = 0.0
Identities = 1319/1319 (100%), Positives = 1319/1319 (100%)
Query: 1 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE 60
MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
Sbjct: 1 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE 60
Query: 61 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC 120
EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
Sbjct: 61 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC 120
Query: 121 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP 180
MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
Sbjct: 121 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP 180
Query: 181 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG 240
SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
Sbjct: 181 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG 240
Query: 241 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ 300
AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
Sbjct: 241 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ 300
Query: 301 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA 360
SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
Sbjct: 301 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA 360
Query: 361 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP 420
ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
Sbjct: 361 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP 420
Query: 421 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP 480
SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
Sbjct: 421 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP 480
Query: 481 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP 540
KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
Sbjct: 481 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP 540
Query: 541 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER 600
AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
Sbjct: 541 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER 600
Query: 601 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA 660
LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
Sbjct: 601 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA 660
Query: 661 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER 720
SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
Sbjct: 661 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER 720
Query: 721 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL 780
AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
Sbjct: 721 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL 780
Query: 781 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS 840
VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
Sbjct: 781 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS 840
Query: 841 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG 900
IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
Sbjct: 841 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG 900
Query: 901 RPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS 960
RPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
Sbjct: 901 RPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS 960
Query: 961 ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW 1020
ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
Sbjct: 961 ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW 1020
Query: 1021 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG 1080
DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
Sbjct: 1021 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG 1080
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR 1140
GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
Sbjct: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR 1140
Query: 1141 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD 1200
EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
Sbjct: 1141 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD 1200
Query: 1201 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI 1260
TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
Sbjct: 1201 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI 1260
Query: 1261 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN 1319
EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
Sbjct: 1261 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN 1319
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 2568 bits (6655), Expect = 0.0
Identities = 1319/1377 (95%), Positives = 1319/1377 (95%), Gaps = 58/1377 (4%)
Query: 1 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE 60
MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
Sbjct: 1 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE 60
Query: 61 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC 120
EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
Sbjct: 61 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC 120
Query: 121 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP 180
MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
Sbjct: 121 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP 180
Query: 181 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG 240
SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
Sbjct: 181 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG 240
Query: 241 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ 300
AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
Sbjct: 241 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ 300
Query: 301 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA 360
SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
Sbjct: 301 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA 360
Query: 361 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP 420
ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
Sbjct: 361 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP 420
Query: 421 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP 480
SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
Sbjct: 421 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP 480
Query: 481 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP 540
KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
Sbjct: 481 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP 540
Query: 541 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER 600
AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
Sbjct: 541 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER 600
Query: 601 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA 660
LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
Sbjct: 601 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA 660
Query: 661 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER 720
SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
Sbjct: 661 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER 720
Query: 721 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL 780
AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
Sbjct: 721 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL 780
Query: 781 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS 840
VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
Sbjct: 781 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS 840
Query: 841 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG 900
IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
Sbjct: 841 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG 900
Query: 901 RPFPKTTSTLKE-----------------------------------------------V 913
RPFPKTTSTLKE V
Sbjct: 901 RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV 960
Query: 914 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR 973
YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
Sbjct: 961 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR 1020
Query: 974 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP 1033
NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
Sbjct: 1021 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP 1080
Query: 1034 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA 1093
SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
Sbjct: 1081 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA 1140
Query: 1094 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR 1153
SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
Sbjct: 1141 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR 1200
Query: 1154 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR 1213
RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
Sbjct: 1201 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR 1260
Query: 1214 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK 1273
GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
Sbjct: 1261 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK 1320
Query: 1274 -----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN 1319
SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
Sbjct: 1321 KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN 1377
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 2568 bits (6655), Expect = 0.0
Identities = 1319/1377 (95%), Positives = 1319/1377 (95%), Gaps = 58/1377 (4%)
Query: 1 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE 60
MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
Sbjct: 1 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE 60
Query: 61 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC 120
EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
Sbjct: 61 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC 120
Query: 121 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP 180
MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
Sbjct: 121 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP 180
Query: 181 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG 240
SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
Sbjct: 181 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG 240
Query: 241 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ 300
AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
Sbjct: 241 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ 300
Query: 301 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA 360
SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
Sbjct: 301 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA 360
Query: 361 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP 420
ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
Sbjct: 361 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP 420
Query: 421 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP 480
SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
Sbjct: 421 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP 480
Query: 481 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP 540
KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
Sbjct: 481 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP 540
Query: 541 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER 600
AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
Sbjct: 541 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER 600
Query: 601 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA 660
LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
Sbjct: 601 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA 660
Query: 661 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER 720
SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
Sbjct: 661 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER 720
Query: 721 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL 780
AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
Sbjct: 721 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL 780
Query: 781 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS 840
VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
Sbjct: 781 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS 840
Query: 841 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG 900
IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
Sbjct: 841 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG 900
Query: 901 RPFPKTTSTLKE-----------------------------------------------V 913
RPFPKTTSTLKE V
Sbjct: 901 RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV 960
Query: 914 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR 973
YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
Sbjct: 961 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR 1020
Query: 974 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP 1033
NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
Sbjct: 1021 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP 1080
Query: 1034 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA 1093
SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
Sbjct: 1081 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA 1140
Query: 1094 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR 1153
SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
Sbjct: 1141 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR 1200
Query: 1154 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR 1213
RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
Sbjct: 1201 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR 1260
Query: 1214 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK 1273
GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
Sbjct: 1261 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK 1320
Query: 1274 -----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN 1319
SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
Sbjct: 1321 KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN 1377
>gi|197313728 pleckstrin homology-like domain, family B, member 2
isoform b [Homo sapiens]
Length = 1237
Score = 657 bits (1695), Expect = 0.0
Identities = 390/838 (46%), Positives = 513/838 (61%), Gaps = 124/838 (14%)
Query: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 434 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 492
Query: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
G ++ I + L L+ P LA
Sbjct: 493 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 552
Query: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
S T R + E SD SST S++ + E +
Sbjct: 553 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 612
Query: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL GE+++E L KE++
Sbjct: 613 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 672
Query: 772 AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
+D L K+ LE I E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LL
Sbjct: 673 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 732
Query: 832 RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891
R AE R+I RKE+++ L QA I QA +E + ++KN + +LQ+EKE L LE
Sbjct: 733 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 792
Query: 892 RRYHSLTGGRPFPKTTSTLKEVYRSKMD-----GEATSPLPRTR---------------- 930
++Y SL+GG+ FP +TLKE Y S + G +T+ P T+
Sbjct: 793 KKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 852
Query: 931 ---------------------------SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL 963
S LP +SS S S AT+GRS +PK+ L
Sbjct: 853 LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 912
Query: 964 T--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW 1020
N GS LP +LAA +D E++R L + Q + E R+ +E + A+E+
Sbjct: 913 LGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYL 970
Query: 1021 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG 1080
++ H +P HS + A+DTLSL+SSDSMETSIS
Sbjct: 971 NSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS-- 1001
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR 1140
ACSPDN+SSAS ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRR
Sbjct: 1002 ---ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRR 1058
Query: 1141 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD 1200
E +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +D
Sbjct: 1059 EILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNID 1118
Query: 1201 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI 1260
TC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAI
Sbjct: 1119 TCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAI 1178
Query: 1261 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1318
EEVYYDHL++A KSPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1179 EEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1236
>gi|21955172 pleckstrin homology-like domain, family B, member 2
isoform c [Homo sapiens]
Length = 1210
Score = 657 bits (1695), Expect = 0.0
Identities = 390/838 (46%), Positives = 513/838 (61%), Gaps = 124/838 (14%)
Query: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
Query: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
G ++ I + L L+ P LA
Sbjct: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
Query: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
S T R + E SD SST S++ + E +
Sbjct: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
Query: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL GE+++E L KE++
Sbjct: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
Query: 772 AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
+D L K+ LE I E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LL
Sbjct: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
Query: 832 RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891
R AE R+I RKE+++ L QA I QA +E + ++KN + +LQ+EKE L LE
Sbjct: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 765
Query: 892 RRYHSLTGGRPFPKTTSTLKEVYRSKMD-----GEATSPLPRTR---------------- 930
++Y SL+GG+ FP +TLKE Y S + G +T+ P T+
Sbjct: 766 KKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 825
Query: 931 ---------------------------SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL 963
S LP +SS S S AT+GRS +PK+ L
Sbjct: 826 LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 885
Query: 964 T--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW 1020
N GS LP +LAA +D E++R L + Q + E R+ +E + A+E+
Sbjct: 886 LGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYL 943
Query: 1021 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG 1080
++ H +P HS + A+DTLSL+SSDSMETSIS
Sbjct: 944 NSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS-- 974
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR 1140
ACSPDN+SSAS ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRR
Sbjct: 975 ---ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRR 1031
Query: 1141 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD 1200
E +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +D
Sbjct: 1032 EILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNID 1091
Query: 1201 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI 1260
TC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAI
Sbjct: 1092 TCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAI 1151
Query: 1261 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1318
EEVYYDHL++A KSPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1152 EEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1209
>gi|197313732 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 637 bits (1644), Expect = 0.0
Identities = 391/881 (44%), Positives = 513/881 (58%), Gaps = 167/881 (18%)
Query: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
Query: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
G ++ I + L L+ P LA
Sbjct: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
Query: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
S T R + E SD SST S++ + E +
Sbjct: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
Query: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL GE+++E L KE++
Sbjct: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
Query: 772 AVDQLQEKLVALETGIQKERDKE------------------------------------- 794
+D L K+ LE I E+ KE
Sbjct: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705
Query: 795 ------AEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848
A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LLR AE R+I RKE++
Sbjct: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
Query: 849 AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908
+ L QA I QA +E + ++KN + +LQ+EKE L LE++Y SL+GG+ FP +
Sbjct: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825
Query: 909 TLKEVYRSKMD-----GEATSPLPRTR--------------------------------- 930
TLKE Y S + G +T+ P T+
Sbjct: 826 TLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER 885
Query: 931 ----------SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLAA 977
S LP +SS S S AT+GRS +PK+ L N GS LP +LAA
Sbjct: 886 KKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAA 945
Query: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFP 1037
+D E++R L + Q + E R+ +E + A+E+ ++ H +P
Sbjct: 946 MAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------YP 992
Query: 1038 PLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD 1097
HS + A+DTLSL+SSDSMETSIS ACSPDN+SSAS +
Sbjct: 993 D---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTSN 1031
Query: 1098 MGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQL 1157
+ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+L
Sbjct: 1032 IARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKL 1091
Query: 1158 VEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLV 1217
+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L+
Sbjct: 1092 IEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLI 1151
Query: 1218 KMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNP 1277
KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A KSPNP
Sbjct: 1152 KMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNP 1211
Query: 1278 ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1318
LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1212 LLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252
>gi|197313730 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 637 bits (1644), Expect = 0.0
Identities = 391/881 (44%), Positives = 513/881 (58%), Gaps = 167/881 (18%)
Query: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
Query: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
G ++ I + L L+ P LA
Sbjct: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
Query: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
S T R + E SD SST S++ + E +
Sbjct: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
Query: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL GE+++E L KE++
Sbjct: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
Query: 772 AVDQLQEKLVALETGIQKERDKE------------------------------------- 794
+D L K+ LE I E+ KE
Sbjct: 646 ILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQ 705
Query: 795 ------AEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERL 848
A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LLR AE R+I RKE++
Sbjct: 706 QQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI 765
Query: 849 AILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTS 908
+ L QA I QA +E + ++KN + +LQ+EKE L LE++Y SL+GG+ FP +
Sbjct: 766 SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPN 825
Query: 909 TLKEVYRSKMD-----GEATSPLPRTR--------------------------------- 930
TLKE Y S + G +T+ P T+
Sbjct: 826 TLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEER 885
Query: 931 ----------SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT--QNGTGS-LPRNLAA 977
S LP +SS S S AT+GRS +PK+ L N GS LP +LAA
Sbjct: 886 KKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAA 945
Query: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFP 1037
+D E++R L + Q + E R+ +E + A+E+ ++ H +P
Sbjct: 946 MAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFH-----------YP 992
Query: 1038 PLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD 1097
HS + A+DTLSL+SSDSMETSIS ACSPDN+SSAS +
Sbjct: 993 D---HSYK-------------DQAFDTLSLDSSDSMETSIS-----ACSPDNISSASTSN 1031
Query: 1098 MGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQL 1157
+ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRRE +E+RLQ E+++RQ+L
Sbjct: 1032 IARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKL 1091
Query: 1158 VEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLV 1217
+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +DTC HV ++ K CRG+L+
Sbjct: 1092 IEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLI 1151
Query: 1218 KMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNP 1277
KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAIEEVYYDHL++A KSPNP
Sbjct: 1152 KMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNP 1211
Query: 1278 ALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1318
LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1212 LLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1252
>gi|157266264 pleckstrin homology-like domain, family B, member 3
[Homo sapiens]
Length = 640
Score = 250 bits (638), Expect = 7e-66
Identities = 215/686 (31%), Positives = 304/686 (44%), Gaps = 154/686 (22%)
Query: 680 ERSDEENLKEECSSTESTQQEHEDAPSTKL--------------QGEVLALEEERAQVLG 725
E+ EE E SSTES++ E P + +G L+ ++ + L
Sbjct: 51 EQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALT 110
Query: 726 HVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALET 785
V ++ RVKEL++Q +E E E+E ALL+GE ER ++E++ + +L E+ A E
Sbjct: 111 RVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASE- 169
Query: 786 GIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRK 845
Q R+ R +E+R L+ + R + E LR ++
Sbjct: 170 --------------------------QRGRQQREQEQRRLSQE---RDRLEGLRQRLRKA 200
Query: 846 ERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPK 905
+ GQ+ +Q + ERL LQ +Q+ +E+L V +R Y L
Sbjct: 201 Q---------GQLDSQPEDQRERL-------LQGVQEMREQLDVAQRAYEDLE------- 237
Query: 906 TTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQ 965
+++ R E R P P Q S+A R + +
Sbjct: 238 ----FQQLERESRQEE------EDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLE 287
Query: 966 NGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELK---------------- 1009
SL +AA + + K++ ALQ + ++R RL EL
Sbjct: 288 EQLKSLGEQMAAESRGLSRKKEEALQ-----ALSQERSRLLELNCLQGTPGGDFSEPNPA 342
Query: 1010 -------QKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHL------PAGRERGE 1056
QK + DA+ +A P F +H S+ + R+RGE
Sbjct: 343 LTKLLFTQKTDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLPRKRGE 400
Query: 1057 EGEHAYDT--LSLESSDSMETSI--STGGNSACSP--DNMSSASGLDMGKIE----EMEK 1106
G LS ++S+E S G+S P ++ G G I ME+
Sbjct: 401 RGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMER 460
Query: 1107 MLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMRE 1166
+L++A AE+ RL+++RE R + S +
Sbjct: 461 LLQQAMAERERLLKAREG------------------TRRGTEGSSGPAVPAI-------- 494
Query: 1167 KQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSW 1226
P T P DL+ H+E GH + C HV +S CRG LVKMGG+IK+W
Sbjct: 495 -----TAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMGGRIKTW 549
Query: 1227 KKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTH 1286
+KRWF FDR R L+YY DK ETKLKGVIYFQAIEEVYYDHLR A KSPNP LTFCVKT+
Sbjct: 550 RKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLTFCVKTY 609
Query: 1287 DRLYYMVAPSAEAMRIWMDVIVTGAE 1312
+RL+YMVAPS EAMRIWMDVIVT A+
Sbjct: 610 ERLFYMVAPSPEAMRIWMDVIVTAAD 635
Score = 37.4 bits (85), Expect = 0.096
Identities = 35/139 (25%), Positives = 58/139 (41%), Gaps = 16/139 (11%)
Query: 1051 GRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD------------- 1097
G E+ E E + S ESS + +A P + SS G+
Sbjct: 49 GAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEA 108
Query: 1098 MGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEER---RRREQVERRLQSESARR 1154
+ ++ ME+ +KE ++ L E E+ L R L ER RR E+ R L + A
Sbjct: 109 LTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAAS 168
Query: 1155 QQLVEKEVKMREKQFSQAR 1173
+Q ++ + +++ SQ R
Sbjct: 169 EQRGRQQREQEQRRLSQER 187
Score = 37.0 bits (84), Expect = 0.13
Identities = 48/182 (26%), Positives = 74/182 (40%), Gaps = 28/182 (15%)
Query: 594 RRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRP 653
+R RQ+R +EQ ER RLE + R G+L S E L G +
Sbjct: 170 QRGRQQREQEQRRLSQERDRLEGL--------RQRLRKAQGQLDSQPEDQRERLLQGVQE 221
Query: 654 SRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEV 713
R E+ VA QR +E +E E +E E P K+Q
Sbjct: 222 MR----------EQLDVA-QRAYEDLEFQQLE--RESRQEEEDRDSPGPQVPDPKVQELQ 268
Query: 714 LALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEME-RALLQGEREAERALLQKEQKA 772
++ + R L H R++ LE+QL+ + E R L + + EA +AL Q+ +
Sbjct: 269 ASMAQHRRGALQH------RIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRL 322
Query: 773 VD 774
++
Sbjct: 323 LE 324
>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
Length = 1317
Score = 99.8 bits (247), Expect = 2e-20
Identities = 52/140 (37%), Positives = 84/140 (60%), Gaps = 5/140 (3%)
Query: 14 QTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIG----SA 69
+TQ ++++ L L + G G+ + ++ PHL+ + LST I L L+EG+T +G S
Sbjct: 428 ETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDAST 487
Query: 70 ARDISLQGPGLAPEHCYIENLRGTLTLYPC-GNACTIDGLPVRQPTRLTQGCMLCLGQST 128
+DI L G L EHC EN+ GT+TL P G+ C+++G+ + + T L QG ++ LG++
Sbjct: 488 EQDIVLHGLDLESEHCIFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTN 547
Query: 129 FLRFNHPAEAKWMKSMIPAG 148
RFNHP EA ++ +G
Sbjct: 548 MFRFNHPKEAAKLREKRKSG 567
Score = 46.6 bits (109), Expect = 2e-04
Identities = 97/475 (20%), Positives = 196/475 (41%), Gaps = 69/475 (14%)
Query: 578 SITEISDNEDDL---------LEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRAD 628
S+T++S + ++L LE+ R+QR+E + + +L + E + AE R
Sbjct: 575 SMTDLSKSRENLSAVMLYNPGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQ 634
Query: 629 GGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLK 688
E+ + + T + L R+ L S + + L E+ +EE L+
Sbjct: 635 Q-----EVETQRKETEIVQLQIRKQEESLKRRSFHIENK----LKDLLAEKEKFEEERLR 685
Query: 689 EECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREA 748
E QQE E + + L ++EE R+KEL + +
Sbjct: 686 E--------QQEIELQKKRQEEETFLRVQEELQ-----------RLKELNNNEKAEKFQI 726
Query: 749 EMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALET----ETKL 804
E LQ E++ + A L+ E+K +++ +++ V L ++++ ++ E ++ E +
Sbjct: 727 FQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQW 786
Query: 805 FEDLEFQQLE--RESRVEEERELAG---QGLLRSKAELLRSIAKRKERLAILDSQAGQIR 859
E+ E + LE RES + + AG G KA+L KR++ + +++ + ++
Sbjct: 787 VEE-EKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQ 845
Query: 860 AQAVQESERLARDKNASLQLLQKEKEKLT-VLERRYHSLTGGRPFPKTTSTLKEV-YRSK 917
+ + + E +++ L+ L+ E +K + +LE+ S+T P+ +K V YR +
Sbjct: 846 QKDILKKE--VQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQ 903
Query: 918 MDGEATSPLPRTR----------------SGPLPSSSGSSSSSSQL--SVATLGRSPSPK 959
L + GPL + ++ L + +
Sbjct: 904 YKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANA 963
Query: 960 SALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAA 1014
+ L T N+A + + K + L+ + +Q E R LA L+++ +A
Sbjct: 964 NQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSA 1018
Score = 43.1 bits (100), Expect = 0.002
Identities = 52/232 (22%), Positives = 103/232 (44%), Gaps = 16/232 (6%)
Query: 578 SITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELP 637
S+T++++ D + + + + +E++++ L + L T+L E RA + G L
Sbjct: 881 SVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLE---EKQRAFEILDRGPL- 936
Query: 638 SIGEATAALALAGRRPSRGLAGASGRSSEEPGV-ATQRLWESMERSDEENLKEECSSTES 696
S+ + LA +++ + AT ++ R +E+ K+E ES
Sbjct: 937 SLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILES 996
Query: 697 TQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQ 756
+++ +A LA E R L L + ++E Q+L S E++ LQ
Sbjct: 997 REKQQREALE-----RALARLERRHSALQRHSTLGMEIEEQRQKLA-SLNSGSREQSGLQ 1050
Query: 757 GEREAERALLQKEQK----AVDQLQEKLVALETGIQKERDKEAEALETETKL 804
EAE+ L+K+Q+ + QL++K+ ++ G+QK+ E + L
Sbjct: 1051 ASLEAEQEALEKDQERLEYEIQQLKQKIYEVD-GVQKDHHGTLEGKVASSSL 1101
Score = 31.2 bits (69), Expect = 6.9
Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 9/75 (12%)
Query: 1101 IEEMEKMLKEAHAEKNRL---MESREREMEL----RRQALEEERRRREQVERRLQSESAR 1153
IEEME+ K AE R+ +E++ +E E+ R+ E +RR +E +L+ A
Sbjct: 616 IEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAE 675
Query: 1154 RQQLVEKEVKMREKQ 1168
+++ +E ++RE+Q
Sbjct: 676 KEKF--EEERLREQQ 688
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 79.7 bits (195), Expect = 2e-14
Identities = 152/688 (22%), Positives = 269/688 (39%), Gaps = 112/688 (16%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEA 633
E + +I NE ++ H + +E+L E+E R ++ +LE + + A
Sbjct: 932 EEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR-QKLQLEKVT------AEAKIKKME 984
Query: 634 GELPSIGEATAALALAGRRPSRGLAGASGRSSEEP----GVATQRLWESMERSD-EENLK 688
E+ + + + + +A S + +EE +A R + + SD EE LK
Sbjct: 985 EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044
Query: 689 EECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQ------ 742
+E E T+QE E A KL GE L+++ A++ +++LK+++ + E++LQ
Sbjct: 1045 KE----EKTRQELEKA-KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARG 1099
Query: 743 -----------ESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKER 791
+ RE + + A LQ + E+E+A K +K L E+L AL+T ++
Sbjct: 1100 DDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159
Query: 792 DKEA-----------------EALETETK---------------LFEDLEFQQLERESRV 819
D A +ALE ETK E+L +QLE+ R
Sbjct: 1160 DTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELS-EQLEQAKRF 1218
Query: 820 EEERELAGQGLLRSKAELLRSI-------AKRKERLAILDSQAGQIRAQAVQESERLARD 872
+ E QGL EL + A+ + + LD+Q ++ A+ V E +RL +
Sbjct: 1219 KANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK-VSEGDRLRVE 1277
Query: 873 KNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMD--GEATSPLPRTR 930
LQ E + ++ L G F K ++L+ + + E T
Sbjct: 1278 LAEKASKLQNELDNVSTLLEEAEK--KGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 931 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIET----KR 986
S +S Q R K L Q+ + + L IE+ K+
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 987 QLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDAL--------HGAAPFPAGPSGFPP 1038
+L + E++ + +K Q + D L A+ F
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 1039 LM--HHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGN--------SACSPD 1088
L+ SI R+R E +T +L + ++E ++ A D
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515
Query: 1089 NMSSASGLDMGK-IEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRL 1147
MSS D+GK + E+EK R +E + EM + + LE+E + E + RL
Sbjct: 1516 LMSSKD--DVGKNVHELEK--------SKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Query: 1148 QSESARRQQLVEKEVKMREKQFSQARPL 1175
+ + E++++ R++Q + + L
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRL 1593
Score = 67.4 bits (163), Expect = 9e-11
Identities = 139/628 (22%), Positives = 256/628 (40%), Gaps = 88/628 (14%)
Query: 583 SDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLC-AEYSRADGGPEAGELPSIGE 641
+DN++ E Q+ + E + ++L+ Q E + + R + +A +L + E
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN--E 1288
Query: 642 ATAALALAGRRPSRGLAGASGRSSEEPGVA-TQRLWESMER------SDEENLKEECSST 694
L +G+ A +S E + TQ L + R S L+EE +S
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSL 1348
Query: 695 ESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERAL 754
+ Q+E E+A L+ +VLAL+ + A V+ ++ LE+ ++ ++AE AL
Sbjct: 1349 QEQQEEEEEARKN-LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE---AL 1404
Query: 755 LQGEREAERALL-QKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQL 813
Q R E+AL K +K ++LQ++L L + +R + A LE + K F+ L ++
Sbjct: 1405 SQ--RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR-QVASNLEKKQKKFDQLLAEEK 1461
Query: 814 ERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDK 873
+R EER+ R++AE A+ KE A+ ++A + +A +E ER +
Sbjct: 1462 SISARYAEERD-------RAEAE-----AREKETKALSLARALEEALEAKEEFERQNKQL 1509
Query: 874 NASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGP 933
A ++ L K+ + + H L + + E R++++ E L T
Sbjct: 1510 RADMEDLMSSKDDVG---KNVHELEKSK---RALEQQVEEMRTQLE-ELEDELQATEDAK 1562
Query: 934 LPSSSGSSSSSSQLS--VATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQ 991
L + +Q + T K LL + R L A L+D +R LA+
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ-----VRELEAELEDERKQRALAVA 1617
Query: 992 QKGQ--------------------QVIEEQRRRLAELK--QKAAAEAQCQWDALHGAAPF 1029
K + +VI++ R+ A++K Q+ EA+ D + +
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE 1677
Query: 1030 PAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDN 1089
+ L + E D L+ E ++S G SA +
Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS------ASGKSALLDEK 1731
Query: 1090 MSSASGLDMGKIEEMEKMLKEAHAEKNRL----------MESREREMELRRQALEEERRR 1139
+ +I ++E+ L+E + L +++ E+ R A ++
Sbjct: 1732 RRLEA-----RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA 1786
Query: 1140 REQVERRLQSESARRQQLVEKEVKMREK 1167
R+Q+ER+ + A+ Q+L E VK + K
Sbjct: 1787 RQQLERQNKELKAKLQEL-EGAVKSKFK 1813
Score = 57.0 bits (136), Expect = 1e-07
Identities = 58/229 (25%), Positives = 108/229 (47%), Gaps = 36/229 (15%)
Query: 687 LKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESA- 745
L+EE +S+E ++ H + +L E+ ++ +L +L+ R+ +LE++L+E
Sbjct: 1692 LQEELASSERARR-HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS 1750
Query: 746 ---------REAEMERALLQGEREAERALLQKEQKAVDQLQE-------KLVALETGIQK 789
R+ ++ L E AER+ QK A QL+ KL LE ++
Sbjct: 1751 NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810
Query: 790 ERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAEL----------LR 839
+ ALE + E +QLE+E++ ER A + + R++ +L R
Sbjct: 1811 KFKATISALEAKIGQLE----EQLEQEAK---ERAAANKLVRRTEKKLKEIFMQVEDERR 1863
Query: 840 SIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLT 888
+ KE++ +++ Q++ Q ++E+E A NAS + LQ+E + T
Sbjct: 1864 HADQYKEQMEKANARMKQLKRQ-LEEAEEEATRANASRRKLQRELDDAT 1911
Score = 47.4 bits (111), Expect = 9e-05
Identities = 60/230 (26%), Positives = 110/230 (47%), Gaps = 25/230 (10%)
Query: 707 TKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGERE--AERA 764
T+ + E+ A +EE +V +++ ++E+E++ Q+ E + LQ E E AE
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 765 LLQKEQKAVDQ-LQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEER 823
++ A Q L+E L LE+ +++E ++ + L+ E K + Q LE + +E
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERN-QILQNEKKKMQ-AHIQDLEEQL---DEE 962
Query: 824 ELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQ-IRAQAVQE------SERLARDKNAS 876
E A Q L K I K +E + +L+ Q + I+ + + E S +LA ++ +
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022
Query: 877 LQLLQ---KEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEAT 923
L + K++ ++ LE R + KT L++ R K+DGE T
Sbjct: 1023 KNLAKIRNKQEVMISDLEERL------KKEEKTRQELEKAKR-KLDGETT 1065
Score = 39.3 bits (90), Expect = 0.025
Identities = 47/222 (21%), Positives = 94/222 (42%), Gaps = 33/222 (14%)
Query: 670 VATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQ 729
+A +R + + L+ + ++ QE E A +K + + ALE
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE------------ 1820
Query: 730 LKVRVKELEQQLQESARE-AEMERALLQGEREAERALLQ--KEQKAVDQLQEKLVALETG 786
++ +LE+QL++ A+E A + + + E++ + +Q E++ DQ +E++
Sbjct: 1821 --AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR 1878
Query: 787 IQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKE 846
+++ + + EA E T+ SR + +REL + L R ++ K
Sbjct: 1879 MKQLKRQLEEAEEEATR----------ANASRRKLQREL--DDATEANEGLSREVSTLKN 1926
Query: 847 RLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLT 888
RL + G I + + R + ASL+L + E T
Sbjct: 1927 RL----RRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKT 1964
Score = 35.4 bits (80), Expect = 0.36
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 20/109 (18%)
Query: 1099 GKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR------------EQVERR 1146
G++EEME+ ++ EKN L E + E EL +A EE R R +E R
Sbjct: 873 GELEEMERKHQQLLEEKNILAEQLQAETELFAEA--EEMRARLAAKKQELEEILHDLESR 930
Query: 1147 LQSESARRQQLVEKEVKMR------EKQFSQARPLTRYLPIRKEDFDLK 1189
++ E R Q L ++ KM+ E+Q + + L + K + K
Sbjct: 931 VEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAK 979
Score = 34.3 bits (77), Expect = 0.81
Identities = 21/81 (25%), Positives = 45/81 (55%), Gaps = 9/81 (11%)
Query: 1100 KIEEMEKMLK------EAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR 1153
K +E+E++L E E+N+++++ +++M+ Q LEE+ E ++LQ E
Sbjct: 916 KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVT 975
Query: 1154 RQ---QLVEKEVKMREKQFSQ 1171
+ + +E+E+ + E Q S+
Sbjct: 976 AEAKIKKMEEEILLLEDQNSK 996
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 79.7 bits (195), Expect = 2e-14
Identities = 150/694 (21%), Positives = 268/694 (38%), Gaps = 105/694 (15%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEA 633
E++ I+E+ L+E H+R+R +E E ER R+ LE L E +A+
Sbjct: 731 EQQRCISELKAETRSLVEQHKRER----KELEEERAGRKGLEARLQQLGEAHQAETEVLR 786
Query: 634 GELPSIGEATAALALAGRRPSRGLAG-ASGRSSEEPGVATQRLWESMERSDEENLKEECS 692
EL EA AA A + + A+ R E + + +M + LKEEC
Sbjct: 787 REL---AEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843
Query: 693 STESTQQE----------HEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQL- 741
QE H + ++ Q E+ L A+ L V++ +VR ++L L
Sbjct: 844 KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903
Query: 742 ----------QESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKER 791
+E AR + R + + A R L+++ +A D+ E L E
Sbjct: 904 TLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL---------EE 954
Query: 792 DKEAEALETETKLFEDLEFQQLERES-RVEEERELAGQGLLRSKAELLRSIAKRKERLAI 850
+ + T+ L Q +ERE+ ++ E E L+ S+ + +++ +A
Sbjct: 955 QQGRQFCSTQAAL------QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVAR 1008
Query: 851 LDSQAGQIRAQ-AVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTST 909
L + G+ +A A++++ R + L ++ E T+ E H+LT + +
Sbjct: 1009 LTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK 1068
Query: 910 LKEVYRSKM-DGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGT 968
L+ + +++ + E + L +S S GR+ T
Sbjct: 1069 LRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRT----------EPT 1118
Query: 969 GSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAP 1028
G L A + +E Q + QQ + R E ++ + AE + L G
Sbjct: 1119 GPKLEALRAEVSKLEQ------QCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172
Query: 1029 FPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPD 1088
A G S L A R + ++ A D + ++ G A
Sbjct: 1173 EKAQELGHSQSALASAQRELAAFRTKVQDHSKA--------EDEWKAQVARGRQEA---- 1220
Query: 1089 NMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREME-LRRQALEEERRRREQVERRL 1147
KN L+ S E E+ L RQ LE+E +E ++R +
Sbjct: 1221 ------------------------ERKNSLISSLEEEVSILNRQVLEKEGESKE-LKRLV 1255
Query: 1148 QSESARRQQLVEK-EVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVV 1206
+ES + Q+L E+ + E + AR R +R+E L+ E + L
Sbjct: 1256 MAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASEN-LRQE 1314
Query: 1207 LSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTL 1240
L+S+ R ++G ++K+W++++F ++ TL
Sbjct: 1315 LTSQAERA--EELGQELKAWQEKFFQKEQALSTL 1346
Score = 67.8 bits (164), Expect = 7e-11
Identities = 135/619 (21%), Positives = 246/619 (39%), Gaps = 44/619 (7%)
Query: 573 RERKNSITEISDNEDDLLEYHRRQRQER-LREQEMERLERQRLETILNLCAEYSRADGGP 631
RE + E+ L+E +Q++ER +E+E+ RL ++R +L E + A
Sbjct: 972 REAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKA-ARAEL 1030
Query: 632 EAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEEC 691
E ++ E A + L G+ E +A R E+ + + E L++
Sbjct: 1031 EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE---LAKLRGLEAAQIKELEELRQTV 1087
Query: 692 SSTES--TQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAE 749
+ ++E E A + Q E E L E L+ V +LEQQ Q+ +A+
Sbjct: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL---EALRAEVSKLEQQCQKQQEQAD 1144
Query: 750 -MERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDL 808
+ER+L EAERA + A++ LQ +L + + A A + E F
Sbjct: 1145 SLERSL-----EAERASRAERDSALETLQGQLEEKAQELGHSQSALASA-QRELAAFR-- 1196
Query: 809 EFQQLERESRVEEE-RELAGQGLLRSKAELLRS-IAKRKERLAILDSQAGQIRAQAVQES 866
+++ S+ E+E + +G R +AE S I+ +E ++IL+ Q + ES
Sbjct: 1197 --TKVQDHSKAEDEWKAQVARG--RQEAERKNSLISSLEEEVSILNRQV----LEKEGES 1248
Query: 867 ERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPL 926
+ L R A + QK +E+L +L+ S R ++++ +EV + + E
Sbjct: 1249 KELKRLVMAESEKSQKLEERLRLLQAETAS-NSARAAERSSALREEVQSLREEAEKQRVA 1307
Query: 927 PRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKR 986
L S + + Q A + + AL T + + A + ++ +
Sbjct: 1308 SENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHT---STQALVSELLPAK 1364
Query: 987 QLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILH 1046
L Q + +Q E+R R EL+Q A + + L PL
Sbjct: 1365 HLCQQLQAEQAAAEKRHR-EELEQSKQAAGGLRAELLRAQREL----GELIPLRQKVAEQ 1419
Query: 1047 HLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGK---IEE 1103
A + R E+ +A L+ + + + G + LD + ++E
Sbjct: 1420 ERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQE 1479
Query: 1104 MEKMLKEAH---AEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEK 1160
+ + +A AE R +S RE+E+ E + + + +R Q E + VE+
Sbjct: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
Query: 1161 EVKMREKQFSQARPLTRYL 1179
+ +Q Q L++ L
Sbjct: 1540 LEVFQREQTKQVEELSKKL 1558
Score = 63.2 bits (152), Expect = 2e-09
Identities = 144/674 (21%), Positives = 251/674 (37%), Gaps = 131/674 (19%)
Query: 539 SPAYSLGSLTGASPCQSPCVQRKLSS-----GDLRVPVTRERK------NSITEISDNED 587
SPA +G + Q ++++L+ +L + + RK I + D
Sbjct: 200 SPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRID 259
Query: 588 DLLEYHRRQRQERLREQEMERLERQ------RLETILNLCAEYSRADGGPEAGELPSIGE 641
L + +Q L +E+E L + RL L C + + + ++ + E
Sbjct: 260 RLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDL-KTEKSQMDRKINQLSE 318
Query: 642 ATAALALAGRRPS---RGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQ 698
L+ R + + L A +EE ATQ W + E+ L + +
Sbjct: 319 ENGDLSFKLREFASHLQQLQDALNELTEEHSKATQE-WLEKQAQLEKELSAALQDKKCLE 377
Query: 699 QEHEDAPSTKLQGEVLALEE-----------ERAQVLGHVEQLKVRVKEL------EQQL 741
+++E LQG++ LEE E+ +VLG V QL+ +E QL
Sbjct: 378 EKNEI-----LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQL 432
Query: 742 QESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETE 801
Q E ER + + AER ++E +++L +L T +Q ++A E
Sbjct: 433 QARVEMLETERGQQEAKLLAERGHFEEE-------KQQLSSLITDLQSSISNLSQAKE-- 483
Query: 802 TKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLR-SIAKRKERLAILDSQAGQIR- 859
+LE+ S+ R A L S+ L +I ++ + LA L QA + +
Sbjct: 484 ----------ELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA 533
Query: 860 --AQAVQESERLARD-----KNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE 912
AQ +Q+ E+ ++ + S L QKE++ V E++ + T + +E
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 913 VYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLP 972
+ D + L + + ++ QL VA R + S Q L
Sbjct: 594 ASLRERD----AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649
Query: 973 RNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAG 1032
R + +ET RQ Q + Q + E +L +QKA + + +
Sbjct: 650 RKVEELQACVETARQ--EQHEAQAQVAELELQLRSEQQKATEKERVAQE----------- 696
Query: 1033 PSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSS 1092
+ L A +E + + + + ++D++E
Sbjct: 697 --------KDQLQEQLQALKESLKVTKGSLEEEKRRAADALE------------------ 730
Query: 1093 ASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESA 1152
E ++ + E AE L+E +RE R+ LEEER R+ +E RLQ
Sbjct: 731 ----------EQQRCISELKAETRSLVEQHKRE----RKELEEERAGRKGLEARLQQLGE 776
Query: 1153 RRQQLVEKEVKMRE 1166
Q E EV RE
Sbjct: 777 AHQ--AETEVLRRE 788
Score = 60.1 bits (144), Expect = 1e-08
Identities = 138/659 (20%), Positives = 251/659 (38%), Gaps = 169/659 (25%)
Query: 588 DLLEYHRRQRQERL---------REQEMERLERQRLETILNLCA------EYSRADGGPE 632
++LE R Q++ +L +Q++ L +I NL + S+A G
Sbjct: 437 EMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARL 496
Query: 633 AGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSD--------- 683
++ S+ L ++ + LAG ++ E+ Q L + + S
Sbjct: 497 TAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQL 556
Query: 684 -------EENLKEECSSTESTQQEHEDAPSTKLQG-------------EVLALEEERAQV 723
E+ LKE E+T+Q+H +T + ++ ALE+E+A
Sbjct: 557 SSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAK 616
Query: 724 LGHVEQLKVRVKELEQQLQESAREAEMERALL-----------------QGEREAERALL 766
L ++Q E Q S +A+ E+A L Q E +A+ A L
Sbjct: 617 LEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAEL 676
Query: 767 Q-----KEQKAV---------DQLQEKLVALET-------GIQKERDKEAEALETETKLF 805
+ ++QKA DQLQE+L AL+ +++E+ + A+ALE + +
Sbjct: 677 ELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI 736
Query: 806 EDLEFQ-----QLERESRVEEERELAGQGLLRSKAELLRSIAKRKE---RLAILDSQAGQ 857
+L+ + + + R E E E AG+ L ++ + L + + R + ++ A Q
Sbjct: 737 SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796
Query: 858 IRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSK 917
A++ E E+L ++ A + + +++ E +Y G F + TLKE
Sbjct: 797 HTAES--ECEQLVKEVAAWRERYEDSQQE----EAQY-----GAMFQEQLMTLKEECE-- 843
Query: 918 MDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAA 977
+A L + S S+L ++ QN L NLA
Sbjct: 844 ---KARQELQEAK-----EKVAGIESHSELQISR------------QQNELAELHANLAR 883
Query: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFP 1037
LQ ++ K + + Q++ ++ L+ L++K AA ++
Sbjct: 884 ALQQVQEK-----EVRAQKLADD----LSTLQEKMAATSK-------------------- 914
Query: 1038 PLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD 1097
+ R+ GE+ E A L E + + + P+ + G
Sbjct: 915 -----EVARLETLVRKAGEQQETASRELVKEPARAGDR----------QPEWLEEQQGRQ 959
Query: 1098 MGKIE-EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQ 1155
+ ++ M +EA N L R ME + Q +EER ++E+ RL E R Q
Sbjct: 960 FCSTQAALQAMEREAEQMGNELERLRAALMESQGQQ-QEERGQQEREVARLTQERGRAQ 1017
Score = 39.3 bits (90), Expect = 0.025
Identities = 66/284 (23%), Positives = 122/284 (42%), Gaps = 31/284 (10%)
Query: 673 QRLWESMERSDEENLKEECSSTESTQQEHE--------DAPSTKLQGEVLALEEERAQVL 724
QR E ++ + + E E T+Q E D S Q ++ A++ + +
Sbjct: 1524 QRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQ 1583
Query: 725 GHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALE 784
++L+ ++ EL+ QL S +E E LQ E+ +K+Q +LQE+L +LE
Sbjct: 1584 QEAQRLQAQLNELQAQL--SQKEQAAEHYKLQMEKAKTHYDAKKQQN--QELQEQLRSLE 1639
Query: 785 TGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKR 844
++ ++ AEA +L +L+ L+ + + R L Q +RS L +A
Sbjct: 1640 QLQKENKELRAEA----ERLGHELQQAGLKTKEAEQTCRHLTAQ--VRS---LEAQVAHA 1690
Query: 845 KERLAILDSQAGQIRAQAVQESERLARDK----NASLQLLQKEKEKLTVLERRYHSLTGG 900
++L D Q+ A++ E A+ + SL L +E L++ + + G
Sbjct: 1691 DQQLR--DLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDG 1748
Query: 901 RPFP-KTTSTLKEVYRSKMDGEAT---SPLPRTRSGPLPSSSGS 940
P + S + + K++ + +P+P PL SS S
Sbjct: 1749 TSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDS 1792
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 77.0 bits (188), Expect = 1e-13
Identities = 138/683 (20%), Positives = 263/683 (38%), Gaps = 130/683 (19%)
Query: 574 ERKNSITEISDNEDDLLEYHRR--QRQERLREQEMERLERQRLETILNLCAEYSRADGGP 631
E K + T DD + R +R+ER +++ E LERQ+ E+
Sbjct: 78 EAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK---------EFD------ 122
Query: 632 EAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWE---------SMERS 682
P+I +A+ L+L RR A EE + Q +E S +++
Sbjct: 123 -----PTITDAS--LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKN 175
Query: 683 DEENLKEECSSTESTQQEHEDAP-----------------STKLQGEVLALEEERAQVLG 725
D + +E + ++E E+ P +T+ Q E + + + Q+
Sbjct: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISS 235
Query: 726 HV-------EQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQE 778
EQ + E+ +E AE ERA L+ E E ER ++++K D+ +
Sbjct: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAE-ERERIKAEQDKKIADE-RA 293
Query: 779 KLVALETGIQKERDK-EAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAEL 837
++ A E +ER++ EAE E + + E + E R++EE + A + R K E
Sbjct: 294 RIEAEEKAAAQERERREAE----ERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349
Query: 838 LRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSL 897
R+ A+ ++R+ + +A + R +A E E A+ +E+++ LE + H++
Sbjct: 350 KRA-AEERQRIKEEEKRAAEERQRARAEEEEKAK---------VEEQKRNKQLEEKKHAM 399
Query: 898 TGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPS 957
+ T E K++G+ + + +L A L +
Sbjct: 400 -------QETKIKGEKVEQKIEGKWVNE--------------KKAQEDKLQTAVLKKQGE 438
Query: 958 PKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQ 1017
K ++ KR+ + K EE + + ++ E +
Sbjct: 439 EKGT-------------------KVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVK 479
Query: 1018 CQWDALHGAAPFPAGPSGFPPLMHHSILH-----HLPAGRERGEEGEHAYDTLSLESSDS 1072
D G + F M H + H P GR + E A +E+
Sbjct: 480 SFMDRKKGFTEVKSQNGEF---MTHKLKHTENTFSRPGGRASVDTKE-AEGAPQVEAGKR 535
Query: 1073 METSISTGGNSACSP----DNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMEL 1128
+E G + + L++ ++++ + ++ E+ + + E + +L
Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595
Query: 1129 RRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDL 1188
R + EE+RR +E++ERR + +RQ++ E + +K F P L I + L
Sbjct: 596 REE--EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFL 653
Query: 1189 KTHIESSGHGVDTCLHVVLSSKV 1211
++ S GV + + SK+
Sbjct: 654 NKSVQKSS-GVKSTHQAAIVSKI 675
Score = 55.8 bits (133), Expect = 3e-07
Identities = 72/336 (21%), Positives = 139/336 (41%), Gaps = 29/336 (8%)
Query: 562 LSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLC 621
++ L +P R + ++ ++NE E RQER +E E + + +
Sbjct: 125 ITDASLSLPSRRMQNDT----AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDA 180
Query: 622 AEYSRADGGPEAGELP-----SIGEATAALALAGRRPSRG-----LAGASGR-SSEEPGV 670
E + D E E SIGE + + + ++ +G+ SSEEP
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
Query: 671 ATQRLW--------ESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
+R E ME D+E + E + E+ ++E A K + A E +
Sbjct: 241 EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEK 300
Query: 723 VLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREA--ERALLQKEQKAVDQLQEKL 780
E+ + +E E+ +E R AE + + + E+ A ER +++E+K + ++++
Sbjct: 301 AAAQ-ERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRI 359
Query: 781 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGL---LRSKAEL 837
E +ER + E + K+ E +QLE + +E ++ G+ + + K
Sbjct: 360 KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
Query: 838 LRSIAKRKERLAILDSQAGQIRAQAVQESERLARDK 873
+ + K + A+L Q + + + E+L DK
Sbjct: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK 455
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/628 (22%), Positives = 252/628 (40%), Gaps = 82/628 (13%)
Query: 600 RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAG 659
R R +E E +RQ E L + E+ + A A A R R L
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV-ELASRVKAEAEAAREKQRAL-- 1535
Query: 660 ASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEE 719
++ EE + + + +++ E ++ + E+ Q+ E +LQ + + E+
Sbjct: 1536 ---QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE----AELQSKRASFAEK 1588
Query: 720 RAQVLGHVEQLKVRVKELEQQLQESARE-AEMERALLQGEREAERALLQKEQKAVDQLQE 778
AQ+ +++ V V +L ++ + A++ AE ERA + ERE ER L+ + +LQ
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 779 KLVALETGI-QKERDKEAEALETETKLFEDLEFQQLER----ESRVEEERELA---GQGL 830
+ VA + + Q E +K+ E E E + E Q + + E +E++R+LA Q
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 831 LRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVL 890
L ++ EL+R A+ + Q Q R +E RL R+ A+ Q Q+ + +L +
Sbjct: 1709 LAAEQELIRLRAETE--------QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 891 ERRYHSLTGGRPFPKTTS-TLKEVYRSKMDGEATSPLPRTRSGP-LPSSSGSSSSSSQLS 948
L + + S + E + +++ EA L + + + QL+
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 949 VATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE---QRRRL 1005
R + +L + T +I K + A ++ +++ E+ QRRRL
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1880
Query: 1006 AELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTL 1065
E + A+ + + L A+ ++ R + EE + L
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASDSELE-------RQKGLVEDTLRQRRQVEE-----EIL 1928
Query: 1066 SLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE-EMEKMLKEAHAEKN-RLMESRE 1123
+L++S + GK E E+E ++AE R E E
Sbjct: 1929 ALKASFEKAAA----------------------GKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 1124 REMELRRQALEEERRRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQARPL-- 1175
E +RQ EE RRR + E R+Q E+AR+++ +EV+ + + +AR L
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 1176 ------TRYLPIRKEDFDLKTHIESSGH 1197
R L + +E + E H
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAH 2054
Score = 70.5 bits (171), Expect = 1e-11
Identities = 132/612 (21%), Positives = 241/612 (39%), Gaps = 88/612 (14%)
Query: 591 EYHRRQRQE---RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALA 647
E +RQ QE RLR Q + +R+R + + A+ A E +A L
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQRALQALEELR 1542
Query: 648 LAGRRPSRGLAGASGRSSEEPGVA---TQRLWESMERSDEENLKEECSSTE-STQQEHED 703
L R L A + + VA QR E+ +S + E+ + E S Q+EH
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Query: 704 APSTKLQGEVLALEEERAQ-------------VLGHVEQLKVRVKELEQQLQESAREAEM 750
+ + E A ++ A+ L E L++R++ E Q+S +AE
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Query: 751 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF 810
E+ + EREA R KA +Q + E ++K+R + AE + +L + E
Sbjct: 1663 EKQKEEAEREARR-----RGKAEEQAVRQRELAEQELEKQR-QLAEG-TAQQRLAAEQEL 1715
Query: 811 QQLERES-RVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERL 869
+L E+ + E++R+L + L R + E + KR+E L+++ ++RA+
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE----LEAELAKVRAEMEVLLASK 1771
Query: 870 ARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRT 929
AR + S +K K++L R+ L + + +E R + E + R
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFREL--AEEAARLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 930 RSGPLPSSSGSSSSSSQLSVATLGRSPSPKS----ALLTQNGTGSLPRNLAATLQDIETK 985
+ + + +A +G + K+ AL + R LA + E
Sbjct: 1830 EAERVLAE----------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA----EDEAF 1875
Query: 986 RQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL 1045
++ L+++ Q + RLA+L++ + +E + Q +
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------------------- 1916
Query: 1046 HHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE--- 1102
L R+ EE + ++ E + G + + D + S ++
Sbjct: 1917 --LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Query: 1103 ---EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVE------RRLQSESAR 1153
E E+ +EA + + + E R+ ALEE R + +VE R + ESAR
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034
Query: 1154 RQQLVEKEVKMR 1165
+ QL ++ + R
Sbjct: 2035 QLQLAQEAAQKR 2046
Score = 70.1 bits (170), Expect = 1e-11
Identities = 133/640 (20%), Positives = 256/640 (40%), Gaps = 103/640 (16%)
Query: 591 EYHRRQRQERLR-----EQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
E RR+ +ER++ E+E R + LE + L A+ A E E S + A
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 646 LALAGRR-PSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDA 704
A +R + A A +E Q L +++++ ++ L + E+ ++ E+A
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKE-----QELQQTLQQ-EQSVLDQLRGEAEAARRAAEEA 2093
Query: 705 PSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAR-EAEMERALLQGEREAER 763
++Q E E AQ VE+ + + E+Q Q A+ +A E+ + E+EA R
Sbjct: 2094 EEARVQAE-----REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 764 ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEER 823
Q EQ A+ Q Q A + ++K + + L + ++ ++L +L+ E + ++
Sbjct: 2149 RA-QAEQAALRQKQ----AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-TDHQK 2202
Query: 824 ELAGQGLLRSKAELLRSIAKRKE------RLAILDSQAGQIRAQAVQESERLA-RDKNAS 876
L + L R KAE + +R + + + + +++A+ E+ L RDK+ +
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 877 LQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPS 936
+ LQ+E EK+ +E R + + + L + L
Sbjct: 2263 QRFLQEEAEKMK-------------------QVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 937 SSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETK--RQLALQQKG 994
+ + + + + K+ L + A LQ+ + + +QLA + +G
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 995 -QQVIEEQRRRLAE-------LKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL- 1045
Q+ +E +R+R E LK + A ++ Q A A F +H + L
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 1046 -------------------HHLPAGRERGEEGEHAYDTLSLES------SDSMETSISTG 1080
H RE E E + L E+ S+ M+T
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----- 2478
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAH---AEKNRLMESREREMELRRQALEEER 1137
+ L + E + +L+ EK +L + + E+ +Q EE++
Sbjct: 2479 ---VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535
Query: 1138 RRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQ 1171
R+++Q+E+ Q E+ RRQ E+ V+ ++++ Q
Sbjct: 2536 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Score = 69.3 bits (168), Expect = 2e-11
Identities = 144/623 (23%), Positives = 242/623 (38%), Gaps = 84/623 (13%)
Query: 584 DNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEAT 643
+ E+ L E R + +ERL E E LE+QR L ++A EA EL +
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAA-LEKQRQ---LAEAHAQAKAQAEREAKEL----QQR 1396
Query: 644 AALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHED 703
+ R + A RS +E Q+L +S E + ++ ++ S + E+
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 704 APSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGERE--- 760
+LQ E A E +R G ++ L+ R +E E Q +++ EAE R +Q E +
Sbjct: 1454 IRVVRLQLE--ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 761 -----------AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE-------ALETET 802
AE +++Q+A+ L+E + E ++ R E E ALET
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571
Query: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQA 862
+ E E Q +R S E+ +L + L+ + + + + ER A ++A + R +A
Sbjct: 1572 RSAE-AELQS-KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 863 VQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEA 922
+E ER N +L+L + +E V +++ SL + +E R G+A
Sbjct: 1628 ERELERWQLKANEALRLRLQAEE---VAQQK--SLAQAEAEKQKEEAEREARRR---GKA 1679
Query: 923 TSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL---TQNGTGSLPRNLAATL 979
R R + QL+ T + + + L+ + G R L
Sbjct: 1680 EEQAVRQRE----LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735
Query: 980 QDIETKRQLALQQKGQQVIEEQRRRLAE----LKQKAAAEAQCQWDALHGAAPFPAGPSG 1035
+ A QK Q++ E + AE L KA AE + + + A
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795
Query: 1036 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG 1095
F RE EE L+ E+ + + + + +
Sbjct: 1796 F---------------RELAEEAAR-LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 1096 LDMGKI----EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRL---- 1147
+G+ E E LKE AE RL E E RR+ E+ + + +E RL
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 1148 ---QSESARRQQLVEKEVKMREK 1167
SE R++ LVE ++ R +
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQ 1922
Score = 66.2 bits (160), Expect = 2e-10
Identities = 159/722 (22%), Positives = 273/722 (37%), Gaps = 135/722 (18%)
Query: 595 RQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPS 654
R++Q L+ E RL+ + E L AE RA A E + +A L +R S
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQ-AEVERARQVQVALET---AQRSAEAELQSKRAS 1584
Query: 655 RGLAGAS-GRSSEEPGVATQRLWESMER-----SDEENLKEECS-STESTQQEHEDAPST 707
A RS +E VA +L E ER ++ E +EE E Q + +A
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 708 KLQGEVLALEEERAQV---------------LGHVEQLKVRVKELEQQLQESARE----- 747
+LQ E +A ++ AQ G E+ VR +EL +Q E R+
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 748 ------AEMERALL-----QGER-----EAERALLQKEQKAVDQLQEKLVALETGIQKER 791
AE E L QGE+ E E A LQ+E A Q +++L A ++ E
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 792 D------------------KEAEALETETKLFEDLEFQQLERESRVEE---ERELAGQGL 830
+ K + LE E F +L + + EE +R+LA +
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824
Query: 831 LRSKAELLRSIA------------KRKERLAILDSQAGQIRAQAVQESERLARDK----- 873
R +AE R +A K + +A+ + +A R + + E E R +
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 874 -----NASLQLLQKEKEKLTVLERRY----HSLTGGRPFPKTTSTLKEVYRSKMDGEATS 924
+ +L Q K + LER+ +L R + LK + G+A
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 925 PLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIET 984
L R + S ++L A R + + + + ++LAA ++
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAE-EEAAR 2002
Query: 985 KRQLALQQ--KGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLM-- 1040
+R+ AL++ + + +EE RR +Q++A + Q +A F
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Query: 1041 ---------HHSILHHL----PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP 1087
S+L L A R EE E A E++ S + S
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR-QVEEAERLKQSA 2121
Query: 1088 DNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESR----------EREMELRRQALEEER 1137
+ + A E K+ KEA E R ++ + EME ++ E+
Sbjct: 2122 EEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 1138 RRREQVERRLQS------ESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTH 1191
R++ QVE+ L + E+ ++ L+++E++ + + ++A + + +E F ++
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA--ARQRSQVEEELFSVRVQ 2236
Query: 1192 IE 1193
+E
Sbjct: 2237 ME 2238
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/403 (22%), Positives = 163/403 (40%), Gaps = 73/403 (18%)
Query: 554 QSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQR 613
Q V+++L++ L++ T +KN + E RQR + E R++ +
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 614 LETILNLCAEYSRA------DGGP-----EAGELPSIGEATAALALAGRRPSRGLAGASG 662
L + +RA D EA ++ + E A L++A + +R A
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
+++ +A + L E M+ E + + Q+E + +LQ + +E+ AQ
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED----KEQMAQ 2355
Query: 723 VLGHVEQLKVRVKELEQQ--LQESA-------REAEMERALLQGEREAERALLQKEQKAV 773
L Q R E E+Q L+ SA R AEM RA + E +A+R +K
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----RKQA 2410
Query: 774 DQLQEKLVALETGIQK---------------------------ERDKEAEALETETKLFE 806
+++ EKL E Q+ E ++E E L+ E KL +
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470
Query: 807 --DLEFQQLERESRVEEERELAGQGLLRSKAELL---RSIAKRKERLAILDSQAGQIRAQ 861
E Q +++E ++E + L Q L K LL R I + K +L Q+
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERFIEQEKAKLE-------QLFQD 2522
Query: 862 AVQESERLARDKNASLQLLQKEKEKLTV----LERRYHSLTGG 900
V ++++L ++ Q +++E+++L RR H G
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Score = 53.9 bits (128), Expect = 1e-06
Identities = 80/317 (25%), Positives = 133/317 (41%), Gaps = 57/317 (17%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEA 633
ER + + SD+E +RQ+ L E + R RQ E IL L A + +A G
Sbjct: 1893 ERLAQLRKASDSE--------LERQKGLVEDTL-RQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 634 GELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSS 693
EL GR S + E A QR + E
Sbjct: 1944 LELE-----------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEE------------- 1979
Query: 694 TESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERA 753
E ++E E+ L E A + +A L VE+LK +V+E ++L+E A
Sbjct: 1980 -ERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEA-RRLRERA-------- 2028
Query: 754 LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQ-- 811
E+E+ R L ++ A +LQ + A +Q++ + + L+ E + + L +
Sbjct: 2029 ----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 812 ------QLERESRVEEERELAGQGLLRSKAELLRSIAKRK-ERLAILDSQAGQIRAQAVQ 864
+ E+RV+ ERE A +AE L+ A+ + + A + A ++R +A Q
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 865 ESERLARDKNASLQLLQ 881
E+ R A+ + A+L+ Q
Sbjct: 2145 EAARRAQAEQAALRQKQ 2161
Score = 49.7 bits (117), Expect = 2e-05
Identities = 100/481 (20%), Positives = 195/481 (40%), Gaps = 76/481 (15%)
Query: 718 EERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQ-KAVDQL 776
+E+ Q + + VR EQ QE A E+ER GE+ E K+ A+
Sbjct: 1230 QEQIQAMPLADSQAVR----EQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1282
Query: 777 QEKLVALETGIQK-----ERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
+ +LV + ++ ++ K E+ + + DL E + + + + L
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 832 RSKAE---LLRSIAKRKERLAILDS------QAGQIRAQAVQESERLARDKNASLQ--LL 880
R + E + A+ +ERLA +++ Q + AQA ++ER A++ +Q ++
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 881 QKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGS 940
++E+ + +++ R + L++ +++ +A RS
Sbjct: 1403 RREEAAVDAQQQK-------RSIQEELQQLRQSSEAEIQAKARQAEAAERS--------R 1447
Query: 941 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQ----KGQQ 996
++ V L + + + G + L A ++ E +++ A ++ + Q
Sbjct: 1448 LRIEEEIRVVRLQLEATERQ----RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 997 VIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGE 1056
E QR+R AE++ + +A+ + A L L R + E
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAREKQRA-----------------LQALEELRLQAE 1546
Query: 1057 EGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKN 1116
E E +E + ++ ++ T SA + AS + K ++E+ L+E H
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQLERSLQEEHVAVA 1604
Query: 1117 RLMESREREMELRRQALEEERRRREQVER-----RLQSESARRQQLVEKEVKMREKQFSQ 1171
+L E ER R Q E R RE+ ER +L++ A R +L +EV ++K +Q
Sbjct: 1605 QLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV-AQQKSLAQ 1659
Query: 1172 A 1172
A
Sbjct: 1660 A 1660
Score = 35.8 bits (81), Expect = 0.28
Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVE 1159
++EE E++ ++ AE+ + E +E +RQ E + + Q ER E+ QQ ++
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER----EAKELQQRMQ 1398
Query: 1160 KEVKMREKQFSQARPLTR 1177
+EV RE+ A+ R
Sbjct: 1399 EEVVRREEAAVDAQQQKR 1416
Score = 32.7 bits (73), Expect = 2.4
Identities = 72/333 (21%), Positives = 131/333 (39%), Gaps = 50/333 (15%)
Query: 568 RVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRA 627
R + + K ++ + + + ++ + +E + E E E+ + Q+ +L L +E
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-- 2476
Query: 628 DGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENL 687
+ + + + T AL + L R E+ ++L++ E + + L
Sbjct: 2477 ----QTVQQEQLLQETQALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQD-EVAKAQQL 2530
Query: 688 KEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESARE 747
+EE QQ + + Q V ++EE R + H + VR K+ E Q E R
Sbjct: 2531 REE-------QQRQQQQMEQERQRLVASMEEARRR--QHEAEEGVRRKQEELQQLEQQRR 2581
Query: 748 AEMERALLQGEREAER-ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFE 806
+ E + +R E+ LL+++ +A E++ A + K +AL+
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA---- 2637
Query: 807 DLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQES 866
E E E + GL R + A+R + IL ++ Q AQ
Sbjct: 2638 ------------AEAEPEHSFDGLRRKVS------AQRLQEAGILSAEELQRLAQGHTTV 2679
Query: 867 ERLAR--DKNASLQ--------LLQKEKEKLTV 889
+ LAR D LQ LL+ EKL+V
Sbjct: 2680 DELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2712
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/628 (22%), Positives = 252/628 (40%), Gaps = 82/628 (13%)
Query: 600 RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAG 659
R R +E E +RQ E L + E+ + A A A R R L
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV-ELASRVKAEAEAAREKQRAL-- 1539
Query: 660 ASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEE 719
++ EE + + + +++ E ++ + E+ Q+ E +LQ + + E+
Sbjct: 1540 ---QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE----AELQSKRASFAEK 1592
Query: 720 RAQVLGHVEQLKVRVKELEQQLQESARE-AEMERALLQGEREAERALLQKEQKAVDQLQE 778
AQ+ +++ V V +L ++ + A++ AE ERA + ERE ER L+ + +LQ
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652
Query: 779 KLVALETGI-QKERDKEAEALETETKLFEDLEFQQLER----ESRVEEERELA---GQGL 830
+ VA + + Q E +K+ E E E + E Q + + E +E++R+LA Q
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 831 LRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVL 890
L ++ EL+R A+ + Q Q R +E RL R+ A+ Q Q+ + +L +
Sbjct: 1713 LAAEQELIRLRAETE--------QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1764
Query: 891 ERRYHSLTGGRPFPKTTS-TLKEVYRSKMDGEATSPLPRTRSGP-LPSSSGSSSSSSQLS 948
L + + S + E + +++ EA L + + + QL+
Sbjct: 1765 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1824
Query: 949 VATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE---QRRRL 1005
R + +L + T +I K + A ++ +++ E+ QRRRL
Sbjct: 1825 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1884
Query: 1006 AELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTL 1065
E + A+ + + L A+ ++ R + EE + L
Sbjct: 1885 EEQAAQHKADIEERLAQLRKASDSELE-------RQKGLVEDTLRQRRQVEE-----EIL 1932
Query: 1066 SLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE-EMEKMLKEAHAEKN-RLMESRE 1123
+L++S + GK E E+E ++AE R E E
Sbjct: 1933 ALKASFEKAAA----------------------GKAELELELGRIRSNAEDTLRSKEQAE 1970
Query: 1124 REMELRRQALEEERRRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQARPL-- 1175
E +RQ EE RRR + E R+Q E+AR+++ +EV+ + + +AR L
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030
Query: 1176 ------TRYLPIRKEDFDLKTHIESSGH 1197
R L + +E + E H
Sbjct: 2031 RAEQESARQLQLAQEAAQKRLQAEEKAH 2058
Score = 70.5 bits (171), Expect = 1e-11
Identities = 132/612 (21%), Positives = 241/612 (39%), Gaps = 88/612 (14%)
Query: 591 EYHRRQRQE---RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALA 647
E +RQ QE RLR Q + +R+R + + A+ A E +A L
Sbjct: 1490 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQRALQALEELR 1546
Query: 648 LAGRRPSRGLAGASGRSSEEPGVA---TQRLWESMERSDEENLKEECSSTE-STQQEHED 703
L R L A + + VA QR E+ +S + E+ + E S Q+EH
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1606
Query: 704 APSTKLQGEVLALEEERAQ-------------VLGHVEQLKVRVKELEQQLQESAREAEM 750
+ + E A ++ A+ L E L++R++ E Q+S +AE
Sbjct: 1607 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666
Query: 751 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF 810
E+ + EREA R KA +Q + E ++K+R + AE + +L + E
Sbjct: 1667 EKQKEEAEREARR-----RGKAEEQAVRQRELAEQELEKQR-QLAEG-TAQQRLAAEQEL 1719
Query: 811 QQLERES-RVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERL 869
+L E+ + E++R+L + L R + E + KR+E L+++ ++RA+
Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE----LEAELAKVRAEMEVLLASK 1775
Query: 870 ARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRT 929
AR + S +K K++L R+ L + + +E R + E + R
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFREL--AEEAARLRALAEEAKRQRQLAEEDAARQRA 1833
Query: 930 RSGPLPSSSGSSSSSSQLSVATLGRSPSPKS----ALLTQNGTGSLPRNLAATLQDIETK 985
+ + + +A +G + K+ AL + R LA + E
Sbjct: 1834 EAERVLAE----------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA----EDEAF 1879
Query: 986 RQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL 1045
++ L+++ Q + RLA+L++ + +E + Q +
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------------------- 1920
Query: 1046 HHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE--- 1102
L R+ EE + ++ E + G + + D + S ++
Sbjct: 1921 --LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1978
Query: 1103 ---EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVE------RRLQSESAR 1153
E E+ +EA + + + E R+ ALEE R + +VE R + ESAR
Sbjct: 1979 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2038
Query: 1154 RQQLVEKEVKMR 1165
+ QL ++ + R
Sbjct: 2039 QLQLAQEAAQKR 2050
Score = 70.1 bits (170), Expect = 1e-11
Identities = 133/640 (20%), Positives = 256/640 (40%), Gaps = 103/640 (16%)
Query: 591 EYHRRQRQERLR-----EQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
E RR+ +ER++ E+E R + LE + L A+ A E E S + A
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043
Query: 646 LALAGRR-PSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDA 704
A +R + A A +E Q L +++++ ++ L + E+ ++ E+A
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKE-----QELQQTLQQ-EQSVLDQLRGEAEAARRAAEEA 2097
Query: 705 PSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAR-EAEMERALLQGEREAER 763
++Q E E AQ VE+ + + E+Q Q A+ +A E+ + E+EA R
Sbjct: 2098 EEARVQAE-----REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 764 ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEER 823
Q EQ A+ Q Q A + ++K + + L + ++ ++L +L+ E + ++
Sbjct: 2153 RA-QAEQAALRQKQ----AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-TDHQK 2206
Query: 824 ELAGQGLLRSKAELLRSIAKRKE------RLAILDSQAGQIRAQAVQESERLA-RDKNAS 876
L + L R KAE + +R + + + + +++A+ E+ L RDK+ +
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2266
Query: 877 LQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPS 936
+ LQ+E EK+ +E R + + + L + L
Sbjct: 2267 QRFLQEEAEKMK-------------------QVAEEAARLSVAAQEAARLRQLAEEDLAQ 2307
Query: 937 SSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETK--RQLALQQKG 994
+ + + + + K+ L + A LQ+ + + +QLA + +G
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367
Query: 995 -QQVIEEQRRRLAE-------LKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL- 1045
Q+ +E +R+R E LK + A ++ Q A A F +H + L
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2427
Query: 1046 -------------------HHLPAGRERGEEGEHAYDTLSLES------SDSMETSISTG 1080
H RE E E + L E+ S+ M+T
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----- 2482
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAH---AEKNRLMESREREMELRRQALEEER 1137
+ L + E + +L+ EK +L + + E+ +Q EE++
Sbjct: 2483 ---VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2539
Query: 1138 RRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQ 1171
R+++Q+E+ Q E+ RRQ E+ V+ ++++ Q
Sbjct: 2540 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2579
Score = 69.3 bits (168), Expect = 2e-11
Identities = 144/623 (23%), Positives = 242/623 (38%), Gaps = 84/623 (13%)
Query: 584 DNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEAT 643
+ E+ L E R + +ERL E E LE+QR L ++A EA EL +
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAA-LEKQRQ---LAEAHAQAKAQAEREAKEL----QQR 1400
Query: 644 AALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHED 703
+ R + A RS +E Q+L +S E + ++ ++ S + E+
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457
Query: 704 APSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGERE--- 760
+LQ E A E +R G ++ L+ R +E E Q +++ EAE R +Q E +
Sbjct: 1458 IRVVRLQLE--ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1515
Query: 761 -----------AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE-------ALETET 802
AE +++Q+A+ L+E + E ++ R E E ALET
Sbjct: 1516 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1575
Query: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQA 862
+ E E Q +R S E+ +L + L+ + + + + ER A ++A + R +A
Sbjct: 1576 RSAE-AELQS-KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1631
Query: 863 VQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEA 922
+E ER N +L+L + +E V +++ SL + +E R G+A
Sbjct: 1632 ERELERWQLKANEALRLRLQAEE---VAQQK--SLAQAEAEKQKEEAEREARRR---GKA 1683
Query: 923 TSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL---TQNGTGSLPRNLAATL 979
R R + QL+ T + + + L+ + G R L
Sbjct: 1684 EEQAVRQRE----LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1739
Query: 980 QDIETKRQLALQQKGQQVIEEQRRRLAE----LKQKAAAEAQCQWDALHGAAPFPAGPSG 1035
+ A QK Q++ E + AE L KA AE + + + A
Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1799
Query: 1036 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG 1095
F RE EE L+ E+ + + + + +
Sbjct: 1800 F---------------RELAEEAAR-LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Query: 1096 LDMGKI----EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRL---- 1147
+G+ E E LKE AE RL E E RR+ E+ + + +E RL
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903
Query: 1148 ---QSESARRQQLVEKEVKMREK 1167
SE R++ LVE ++ R +
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQ 1926
Score = 66.2 bits (160), Expect = 2e-10
Identities = 159/722 (22%), Positives = 273/722 (37%), Gaps = 135/722 (18%)
Query: 595 RQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPS 654
R++Q L+ E RL+ + E L AE RA A E + +A L +R S
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQ-AEVERARQVQVALET---AQRSAEAELQSKRAS 1588
Query: 655 RGLAGAS-GRSSEEPGVATQRLWESMER-----SDEENLKEECS-STESTQQEHEDAPST 707
A RS +E VA +L E ER ++ E +EE E Q + +A
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1648
Query: 708 KLQGEVLALEEERAQV---------------LGHVEQLKVRVKELEQQLQESARE----- 747
+LQ E +A ++ AQ G E+ VR +EL +Q E R+
Sbjct: 1649 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 748 ------AEMERALL-----QGER-----EAERALLQKEQKAVDQLQEKLVALETGIQKER 791
AE E L QGE+ E E A LQ+E A Q +++L A ++ E
Sbjct: 1709 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1768
Query: 792 D------------------KEAEALETETKLFEDLEFQQLERESRVEE---ERELAGQGL 830
+ K + LE E F +L + + EE +R+LA +
Sbjct: 1769 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1828
Query: 831 LRSKAELLRSIA------------KRKERLAILDSQAGQIRAQAVQESERLARDK----- 873
R +AE R +A K + +A+ + +A R + + E E R +
Sbjct: 1829 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Query: 874 -----NASLQLLQKEKEKLTVLERRY----HSLTGGRPFPKTTSTLKEVYRSKMDGEATS 924
+ +L Q K + LER+ +L R + LK + G+A
Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1948
Query: 925 PLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIET 984
L R + S ++L A R + + + + ++LAA ++
Sbjct: 1949 ELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAE-EEAAR 2006
Query: 985 KRQLALQQ--KGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLM-- 1040
+R+ AL++ + + +EE RR +Q++A + Q +A F
Sbjct: 2007 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066
Query: 1041 ---------HHSILHHL----PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP 1087
S+L L A R EE E A E++ S + S
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR-QVEEAERLKQSA 2125
Query: 1088 DNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESR----------EREMELRRQALEEER 1137
+ + A E K+ KEA E R ++ + EME ++ E+
Sbjct: 2126 EEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 1138 RRREQVERRLQS------ESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTH 1191
R++ QVE+ L + E+ ++ L+++E++ + + ++A + + +E F ++
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA--ARQRSQVEEELFSVRVQ 2240
Query: 1192 IE 1193
+E
Sbjct: 2241 ME 2242
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/403 (22%), Positives = 163/403 (40%), Gaps = 73/403 (18%)
Query: 554 QSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQR 613
Q V+++L++ L++ T +KN + E RQR + E R++ +
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Query: 614 LETILNLCAEYSRA------DGGP-----EAGELPSIGEATAALALAGRRPSRGLAGASG 662
L + +RA D EA ++ + E A L++A + +R A
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
+++ +A + L E M+ E + + Q+E + +LQ + +E+ AQ
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED----KEQMAQ 2359
Query: 723 VLGHVEQLKVRVKELEQQ--LQESA-------REAEMERALLQGEREAERALLQKEQKAV 773
L Q R E E+Q L+ SA R AEM RA + E +A+R +K
Sbjct: 2360 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----RKQA 2414
Query: 774 DQLQEKLVALETGIQK---------------------------ERDKEAEALETETKLFE 806
+++ EKL E Q+ E ++E E L+ E KL +
Sbjct: 2415 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2474
Query: 807 --DLEFQQLERESRVEEERELAGQGLLRSKAELL---RSIAKRKERLAILDSQAGQIRAQ 861
E Q +++E ++E + L Q L K LL R I + K +L Q+
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERFIEQEKAKLE-------QLFQD 2526
Query: 862 AVQESERLARDKNASLQLLQKEKEKLTV----LERRYHSLTGG 900
V ++++L ++ Q +++E+++L RR H G
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569
Score = 53.9 bits (128), Expect = 1e-06
Identities = 80/317 (25%), Positives = 133/317 (41%), Gaps = 57/317 (17%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEA 633
ER + + SD+E +RQ+ L E + R RQ E IL L A + +A G
Sbjct: 1897 ERLAQLRKASDSE--------LERQKGLVEDTL-RQRRQVEEEILALKASFEKAAAGKAE 1947
Query: 634 GELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSS 693
EL GR S + E A QR + E
Sbjct: 1948 LELE-----------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEE------------- 1983
Query: 694 TESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERA 753
E ++E E+ L E A + +A L VE+LK +V+E ++L+E A
Sbjct: 1984 -ERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEA-RRLRERA-------- 2032
Query: 754 LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQ-- 811
E+E+ R L ++ A +LQ + A +Q++ + + L+ E + + L +
Sbjct: 2033 ----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2088
Query: 812 ------QLERESRVEEERELAGQGLLRSKAELLRSIAKRK-ERLAILDSQAGQIRAQAVQ 864
+ E+RV+ ERE A +AE L+ A+ + + A + A ++R +A Q
Sbjct: 2089 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148
Query: 865 ESERLARDKNASLQLLQ 881
E+ R A+ + A+L+ Q
Sbjct: 2149 EAARRAQAEQAALRQKQ 2165
Score = 49.7 bits (117), Expect = 2e-05
Identities = 100/481 (20%), Positives = 195/481 (40%), Gaps = 76/481 (15%)
Query: 718 EERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQ-KAVDQL 776
+E+ Q + + VR EQ QE A E+ER GE+ E K+ A+
Sbjct: 1234 QEQIQAMPLADSQAVR----EQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1286
Query: 777 QEKLVALETGIQK-----ERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
+ +LV + ++ ++ K E+ + + DL E + + + + L
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346
Query: 832 RSKAE---LLRSIAKRKERLAILDS------QAGQIRAQAVQESERLARDKNASLQ--LL 880
R + E + A+ +ERLA +++ Q + AQA ++ER A++ +Q ++
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 881 QKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGS 940
++E+ + +++ R + L++ +++ +A RS
Sbjct: 1407 RREEAAVDAQQQK-------RSIQEELQQLRQSSEAEIQAKARQAEAAERS--------R 1451
Query: 941 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQ----KGQQ 996
++ V L + + + G + L A ++ E +++ A ++ + Q
Sbjct: 1452 LRIEEEIRVVRLQLEATERQ----RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1507
Query: 997 VIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGE 1056
E QR+R AE++ + +A+ + A L L R + E
Sbjct: 1508 QDESQRKRQAEVELASRVKAEAEAAREKQRA-----------------LQALEELRLQAE 1550
Query: 1057 EGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKN 1116
E E +E + ++ ++ T SA + AS + K ++E+ L+E H
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQLERSLQEEHVAVA 1608
Query: 1117 RLMESREREMELRRQALEEERRRREQVER-----RLQSESARRQQLVEKEVKMREKQFSQ 1171
+L E ER R Q E R RE+ ER +L++ A R +L +EV ++K +Q
Sbjct: 1609 QLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV-AQQKSLAQ 1663
Query: 1172 A 1172
A
Sbjct: 1664 A 1664
Score = 35.8 bits (81), Expect = 0.28
Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVE 1159
++EE E++ ++ AE+ + E +E +RQ E + + Q ER E+ QQ ++
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER----EAKELQQRMQ 1402
Query: 1160 KEVKMREKQFSQARPLTR 1177
+EV RE+ A+ R
Sbjct: 1403 EEVVRREEAAVDAQQQKR 1420
Score = 32.7 bits (73), Expect = 2.4
Identities = 72/333 (21%), Positives = 131/333 (39%), Gaps = 50/333 (15%)
Query: 568 RVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRA 627
R + + K ++ + + + ++ + +E + E E E+ + Q+ +L L +E
Sbjct: 2423 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-- 2480
Query: 628 DGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENL 687
+ + + + T AL + L R E+ ++L++ E + + L
Sbjct: 2481 ----QTVQQEQLLQETQALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQD-EVAKAQQL 2534
Query: 688 KEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESARE 747
+EE QQ + + Q V ++EE R + H + VR K+ E Q E R
Sbjct: 2535 REE-------QQRQQQQMEQERQRLVASMEEARRR--QHEAEEGVRRKQEELQQLEQQRR 2585
Query: 748 AEMERALLQGEREAER-ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFE 806
+ E + +R E+ LL+++ +A E++ A + K +AL+
Sbjct: 2586 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA---- 2641
Query: 807 DLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQES 866
E E E + GL R + A+R + IL ++ Q AQ
Sbjct: 2642 ------------AEAEPEHSFDGLRRKVS------AQRLQEAGILSAEELQRLAQGHTTV 2683
Query: 867 ERLAR--DKNASLQ--------LLQKEKEKLTV 889
+ LAR D LQ LL+ EKL+V
Sbjct: 2684 DELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2716
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/628 (22%), Positives = 252/628 (40%), Gaps = 82/628 (13%)
Query: 600 RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAG 659
R R +E E +RQ E L + E+ + A A A R R L
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV-ELASRVKAEAEAAREKQRAL-- 1535
Query: 660 ASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEE 719
++ EE + + + +++ E ++ + E+ Q+ E +LQ + + E+
Sbjct: 1536 ---QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE----AELQSKRASFAEK 1588
Query: 720 RAQVLGHVEQLKVRVKELEQQLQESARE-AEMERALLQGEREAERALLQKEQKAVDQLQE 778
AQ+ +++ V V +L ++ + A++ AE ERA + ERE ER L+ + +LQ
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 779 KLVALETGI-QKERDKEAEALETETKLFEDLEFQQLER----ESRVEEERELA---GQGL 830
+ VA + + Q E +K+ E E E + E Q + + E +E++R+LA Q
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 831 LRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVL 890
L ++ EL+R A+ + Q Q R +E RL R+ A+ Q Q+ + +L +
Sbjct: 1709 LAAEQELIRLRAETE--------QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 891 ERRYHSLTGGRPFPKTTS-TLKEVYRSKMDGEATSPLPRTRSGP-LPSSSGSSSSSSQLS 948
L + + S + E + +++ EA L + + + QL+
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 949 VATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE---QRRRL 1005
R + +L + T +I K + A ++ +++ E+ QRRRL
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1880
Query: 1006 AELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTL 1065
E + A+ + + L A+ ++ R + EE + L
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASDSELE-------RQKGLVEDTLRQRRQVEE-----EIL 1928
Query: 1066 SLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE-EMEKMLKEAHAEKN-RLMESRE 1123
+L++S + GK E E+E ++AE R E E
Sbjct: 1929 ALKASFEKAAA----------------------GKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 1124 REMELRRQALEEERRRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQARPL-- 1175
E +RQ EE RRR + E R+Q E+AR+++ +EV+ + + +AR L
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 1176 ------TRYLPIRKEDFDLKTHIESSGH 1197
R L + +E + E H
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAH 2054
Score = 70.5 bits (171), Expect = 1e-11
Identities = 132/612 (21%), Positives = 241/612 (39%), Gaps = 88/612 (14%)
Query: 591 EYHRRQRQE---RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALA 647
E +RQ QE RLR Q + +R+R + + A+ A E +A L
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQRALQALEELR 1542
Query: 648 LAGRRPSRGLAGASGRSSEEPGVA---TQRLWESMERSDEENLKEECSSTE-STQQEHED 703
L R L A + + VA QR E+ +S + E+ + E S Q+EH
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Query: 704 APSTKLQGEVLALEEERAQ-------------VLGHVEQLKVRVKELEQQLQESAREAEM 750
+ + E A ++ A+ L E L++R++ E Q+S +AE
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Query: 751 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF 810
E+ + EREA R KA +Q + E ++K+R + AE + +L + E
Sbjct: 1663 EKQKEEAEREARR-----RGKAEEQAVRQRELAEQELEKQR-QLAEG-TAQQRLAAEQEL 1715
Query: 811 QQLERES-RVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERL 869
+L E+ + E++R+L + L R + E + KR+E L+++ ++RA+
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE----LEAELAKVRAEMEVLLASK 1771
Query: 870 ARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRT 929
AR + S +K K++L R+ L + + +E R + E + R
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFREL--AEEAARLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 930 RSGPLPSSSGSSSSSSQLSVATLGRSPSPKS----ALLTQNGTGSLPRNLAATLQDIETK 985
+ + + +A +G + K+ AL + R LA + E
Sbjct: 1830 EAERVLAE----------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA----EDEAF 1875
Query: 986 RQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL 1045
++ L+++ Q + RLA+L++ + +E + Q +
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------------------- 1916
Query: 1046 HHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE--- 1102
L R+ EE + ++ E + G + + D + S ++
Sbjct: 1917 --LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Query: 1103 ---EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVE------RRLQSESAR 1153
E E+ +EA + + + E R+ ALEE R + +VE R + ESAR
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034
Query: 1154 RQQLVEKEVKMR 1165
+ QL ++ + R
Sbjct: 2035 QLQLAQEAAQKR 2046
Score = 70.1 bits (170), Expect = 1e-11
Identities = 133/640 (20%), Positives = 256/640 (40%), Gaps = 103/640 (16%)
Query: 591 EYHRRQRQERLR-----EQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
E RR+ +ER++ E+E R + LE + L A+ A E E S + A
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 646 LALAGRR-PSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDA 704
A +R + A A +E Q L +++++ ++ L + E+ ++ E+A
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKE-----QELQQTLQQ-EQSVLDQLRGEAEAARRAAEEA 2093
Query: 705 PSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAR-EAEMERALLQGEREAER 763
++Q E E AQ VE+ + + E+Q Q A+ +A E+ + E+EA R
Sbjct: 2094 EEARVQAE-----REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 764 ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEER 823
Q EQ A+ Q Q A + ++K + + L + ++ ++L +L+ E + ++
Sbjct: 2149 RA-QAEQAALRQKQ----AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-TDHQK 2202
Query: 824 ELAGQGLLRSKAELLRSIAKRKE------RLAILDSQAGQIRAQAVQESERLA-RDKNAS 876
L + L R KAE + +R + + + + +++A+ E+ L RDK+ +
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 877 LQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPS 936
+ LQ+E EK+ +E R + + + L + L
Sbjct: 2263 QRFLQEEAEKMK-------------------QVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 937 SSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETK--RQLALQQKG 994
+ + + + + K+ L + A LQ+ + + +QLA + +G
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 995 -QQVIEEQRRRLAE-------LKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL- 1045
Q+ +E +R+R E LK + A ++ Q A A F +H + L
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 1046 -------------------HHLPAGRERGEEGEHAYDTLSLES------SDSMETSISTG 1080
H RE E E + L E+ S+ M+T
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----- 2478
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAH---AEKNRLMESREREMELRRQALEEER 1137
+ L + E + +L+ EK +L + + E+ +Q EE++
Sbjct: 2479 ---VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535
Query: 1138 RRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQ 1171
R+++Q+E+ Q E+ RRQ E+ V+ ++++ Q
Sbjct: 2536 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Score = 69.3 bits (168), Expect = 2e-11
Identities = 144/623 (23%), Positives = 242/623 (38%), Gaps = 84/623 (13%)
Query: 584 DNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEAT 643
+ E+ L E R + +ERL E E LE+QR L ++A EA EL +
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAA-LEKQRQ---LAEAHAQAKAQAEREAKEL----QQR 1396
Query: 644 AALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHED 703
+ R + A RS +E Q+L +S E + ++ ++ S + E+
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 704 APSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGERE--- 760
+LQ E A E +R G ++ L+ R +E E Q +++ EAE R +Q E +
Sbjct: 1454 IRVVRLQLE--ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 761 -----------AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE-------ALETET 802
AE +++Q+A+ L+E + E ++ R E E ALET
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571
Query: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQA 862
+ E E Q +R S E+ +L + L+ + + + + ER A ++A + R +A
Sbjct: 1572 RSAE-AELQS-KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 863 VQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEA 922
+E ER N +L+L + +E V +++ SL + +E R G+A
Sbjct: 1628 ERELERWQLKANEALRLRLQAEE---VAQQK--SLAQAEAEKQKEEAEREARRR---GKA 1679
Query: 923 TSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL---TQNGTGSLPRNLAATL 979
R R + QL+ T + + + L+ + G R L
Sbjct: 1680 EEQAVRQRE----LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735
Query: 980 QDIETKRQLALQQKGQQVIEEQRRRLAE----LKQKAAAEAQCQWDALHGAAPFPAGPSG 1035
+ A QK Q++ E + AE L KA AE + + + A
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795
Query: 1036 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG 1095
F RE EE L+ E+ + + + + +
Sbjct: 1796 F---------------RELAEEAAR-LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 1096 LDMGKI----EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRL---- 1147
+G+ E E LKE AE RL E E RR+ E+ + + +E RL
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 1148 ---QSESARRQQLVEKEVKMREK 1167
SE R++ LVE ++ R +
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQ 1922
Score = 66.2 bits (160), Expect = 2e-10
Identities = 159/722 (22%), Positives = 273/722 (37%), Gaps = 135/722 (18%)
Query: 595 RQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPS 654
R++Q L+ E RL+ + E L AE RA A E + +A L +R S
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQ-AEVERARQVQVALET---AQRSAEAELQSKRAS 1584
Query: 655 RGLAGAS-GRSSEEPGVATQRLWESMER-----SDEENLKEECS-STESTQQEHEDAPST 707
A RS +E VA +L E ER ++ E +EE E Q + +A
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 708 KLQGEVLALEEERAQV---------------LGHVEQLKVRVKELEQQLQESARE----- 747
+LQ E +A ++ AQ G E+ VR +EL +Q E R+
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 748 ------AEMERALL-----QGER-----EAERALLQKEQKAVDQLQEKLVALETGIQKER 791
AE E L QGE+ E E A LQ+E A Q +++L A ++ E
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 792 D------------------KEAEALETETKLFEDLEFQQLERESRVEE---ERELAGQGL 830
+ K + LE E F +L + + EE +R+LA +
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824
Query: 831 LRSKAELLRSIA------------KRKERLAILDSQAGQIRAQAVQESERLARDK----- 873
R +AE R +A K + +A+ + +A R + + E E R +
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 874 -----NASLQLLQKEKEKLTVLERRY----HSLTGGRPFPKTTSTLKEVYRSKMDGEATS 924
+ +L Q K + LER+ +L R + LK + G+A
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 925 PLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIET 984
L R + S ++L A R + + + + ++LAA ++
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAE-EEAAR 2002
Query: 985 KRQLALQQ--KGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLM-- 1040
+R+ AL++ + + +EE RR +Q++A + Q +A F
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Query: 1041 ---------HHSILHHL----PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP 1087
S+L L A R EE E A E++ S + S
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR-QVEEAERLKQSA 2121
Query: 1088 DNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESR----------EREMELRRQALEEER 1137
+ + A E K+ KEA E R ++ + EME ++ E+
Sbjct: 2122 EEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 1138 RRREQVERRLQS------ESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTH 1191
R++ QVE+ L + E+ ++ L+++E++ + + ++A + + +E F ++
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA--ARQRSQVEEELFSVRVQ 2236
Query: 1192 IE 1193
+E
Sbjct: 2237 ME 2238
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/403 (22%), Positives = 163/403 (40%), Gaps = 73/403 (18%)
Query: 554 QSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQR 613
Q V+++L++ L++ T +KN + E RQR + E R++ +
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 614 LETILNLCAEYSRA------DGGP-----EAGELPSIGEATAALALAGRRPSRGLAGASG 662
L + +RA D EA ++ + E A L++A + +R A
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
+++ +A + L E M+ E + + Q+E + +LQ + +E+ AQ
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED----KEQMAQ 2355
Query: 723 VLGHVEQLKVRVKELEQQ--LQESA-------REAEMERALLQGEREAERALLQKEQKAV 773
L Q R E E+Q L+ SA R AEM RA + E +A+R +K
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----RKQA 2410
Query: 774 DQLQEKLVALETGIQK---------------------------ERDKEAEALETETKLFE 806
+++ EKL E Q+ E ++E E L+ E KL +
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470
Query: 807 --DLEFQQLERESRVEEERELAGQGLLRSKAELL---RSIAKRKERLAILDSQAGQIRAQ 861
E Q +++E ++E + L Q L K LL R I + K +L Q+
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERFIEQEKAKLE-------QLFQD 2522
Query: 862 AVQESERLARDKNASLQLLQKEKEKLTV----LERRYHSLTGG 900
V ++++L ++ Q +++E+++L RR H G
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Score = 53.9 bits (128), Expect = 1e-06
Identities = 80/317 (25%), Positives = 133/317 (41%), Gaps = 57/317 (17%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEA 633
ER + + SD+E +RQ+ L E + R RQ E IL L A + +A G
Sbjct: 1893 ERLAQLRKASDSE--------LERQKGLVEDTL-RQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 634 GELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSS 693
EL GR S + E A QR + E
Sbjct: 1944 LELE-----------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEE------------- 1979
Query: 694 TESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERA 753
E ++E E+ L E A + +A L VE+LK +V+E ++L+E A
Sbjct: 1980 -ERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEA-RRLRERA-------- 2028
Query: 754 LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQ-- 811
E+E+ R L ++ A +LQ + A +Q++ + + L+ E + + L +
Sbjct: 2029 ----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 812 ------QLERESRVEEERELAGQGLLRSKAELLRSIAKRK-ERLAILDSQAGQIRAQAVQ 864
+ E+RV+ ERE A +AE L+ A+ + + A + A ++R +A Q
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 865 ESERLARDKNASLQLLQ 881
E+ R A+ + A+L+ Q
Sbjct: 2145 EAARRAQAEQAALRQKQ 2161
Score = 49.7 bits (117), Expect = 2e-05
Identities = 100/481 (20%), Positives = 195/481 (40%), Gaps = 76/481 (15%)
Query: 718 EERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQ-KAVDQL 776
+E+ Q + + VR EQ QE A E+ER GE+ E K+ A+
Sbjct: 1230 QEQIQAMPLADSQAVR----EQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1282
Query: 777 QEKLVALETGIQK-----ERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
+ +LV + ++ ++ K E+ + + DL E + + + + L
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 832 RSKAE---LLRSIAKRKERLAILDS------QAGQIRAQAVQESERLARDKNASLQ--LL 880
R + E + A+ +ERLA +++ Q + AQA ++ER A++ +Q ++
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 881 QKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGS 940
++E+ + +++ R + L++ +++ +A RS
Sbjct: 1403 RREEAAVDAQQQK-------RSIQEELQQLRQSSEAEIQAKARQAEAAERS--------R 1447
Query: 941 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQ----KGQQ 996
++ V L + + + G + L A ++ E +++ A ++ + Q
Sbjct: 1448 LRIEEEIRVVRLQLEATERQ----RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 997 VIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGE 1056
E QR+R AE++ + +A+ + A L L R + E
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAREKQRA-----------------LQALEELRLQAE 1546
Query: 1057 EGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKN 1116
E E +E + ++ ++ T SA + AS + K ++E+ L+E H
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQLERSLQEEHVAVA 1604
Query: 1117 RLMESREREMELRRQALEEERRRREQVER-----RLQSESARRQQLVEKEVKMREKQFSQ 1171
+L E ER R Q E R RE+ ER +L++ A R +L +EV ++K +Q
Sbjct: 1605 QLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV-AQQKSLAQ 1659
Query: 1172 A 1172
A
Sbjct: 1660 A 1660
Score = 35.8 bits (81), Expect = 0.28
Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVE 1159
++EE E++ ++ AE+ + E +E +RQ E + + Q ER E+ QQ ++
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER----EAKELQQRMQ 1398
Query: 1160 KEVKMREKQFSQARPLTR 1177
+EV RE+ A+ R
Sbjct: 1399 EEVVRREEAAVDAQQQKR 1416
Score = 32.7 bits (73), Expect = 2.4
Identities = 72/333 (21%), Positives = 131/333 (39%), Gaps = 50/333 (15%)
Query: 568 RVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRA 627
R + + K ++ + + + ++ + +E + E E E+ + Q+ +L L +E
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-- 2476
Query: 628 DGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENL 687
+ + + + T AL + L R E+ ++L++ E + + L
Sbjct: 2477 ----QTVQQEQLLQETQALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQD-EVAKAQQL 2530
Query: 688 KEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESARE 747
+EE QQ + + Q V ++EE R + H + VR K+ E Q E R
Sbjct: 2531 REE-------QQRQQQQMEQERQRLVASMEEARRR--QHEAEEGVRRKQEELQQLEQQRR 2581
Query: 748 AEMERALLQGEREAER-ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFE 806
+ E + +R E+ LL+++ +A E++ A + K +AL+
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA---- 2637
Query: 807 DLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQES 866
E E E + GL R + A+R + IL ++ Q AQ
Sbjct: 2638 ------------AEAEPEHSFDGLRRKVS------AQRLQEAGILSAEELQRLAQGHTTV 2679
Query: 867 ERLAR--DKNASLQ--------LLQKEKEKLTV 889
+ LAR D LQ LL+ EKL+V
Sbjct: 2680 DELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2712
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/628 (22%), Positives = 252/628 (40%), Gaps = 82/628 (13%)
Query: 600 RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAG 659
R R +E E +RQ E L + E+ + A A A R R L
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV-ELASRVKAEAEAAREKQRAL-- 1503
Query: 660 ASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEE 719
++ EE + + + +++ E ++ + E+ Q+ E +LQ + + E+
Sbjct: 1504 ---QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE----AELQSKRASFAEK 1556
Query: 720 RAQVLGHVEQLKVRVKELEQQLQESARE-AEMERALLQGEREAERALLQKEQKAVDQLQE 778
AQ+ +++ V V +L ++ + A++ AE ERA + ERE ER L+ + +LQ
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616
Query: 779 KLVALETGI-QKERDKEAEALETETKLFEDLEFQQLER----ESRVEEERELA---GQGL 830
+ VA + + Q E +K+ E E E + E Q + + E +E++R+LA Q
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676
Query: 831 LRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVL 890
L ++ EL+R A+ + Q Q R +E RL R+ A+ Q Q+ + +L +
Sbjct: 1677 LAAEQELIRLRAETE--------QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1728
Query: 891 ERRYHSLTGGRPFPKTTS-TLKEVYRSKMDGEATSPLPRTRSGP-LPSSSGSSSSSSQLS 948
L + + S + E + +++ EA L + + + QL+
Sbjct: 1729 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1788
Query: 949 VATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE---QRRRL 1005
R + +L + T +I K + A ++ +++ E+ QRRRL
Sbjct: 1789 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1848
Query: 1006 AELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTL 1065
E + A+ + + L A+ ++ R + EE + L
Sbjct: 1849 EEQAAQHKADIEERLAQLRKASDSELE-------RQKGLVEDTLRQRRQVEE-----EIL 1896
Query: 1066 SLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE-EMEKMLKEAHAEKN-RLMESRE 1123
+L++S + GK E E+E ++AE R E E
Sbjct: 1897 ALKASFEKAAA----------------------GKAELELELGRIRSNAEDTLRSKEQAE 1934
Query: 1124 REMELRRQALEEERRRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQARPL-- 1175
E +RQ EE RRR + E R+Q E+AR+++ +EV+ + + +AR L
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994
Query: 1176 ------TRYLPIRKEDFDLKTHIESSGH 1197
R L + +E + E H
Sbjct: 1995 RAEQESARQLQLAQEAAQKRLQAEEKAH 2022
Score = 70.5 bits (171), Expect = 1e-11
Identities = 132/612 (21%), Positives = 241/612 (39%), Gaps = 88/612 (14%)
Query: 591 EYHRRQRQE---RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALA 647
E +RQ QE RLR Q + +R+R + + A+ A E +A L
Sbjct: 1454 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQRALQALEELR 1510
Query: 648 LAGRRPSRGLAGASGRSSEEPGVA---TQRLWESMERSDEENLKEECSSTE-STQQEHED 703
L R L A + + VA QR E+ +S + E+ + E S Q+EH
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1570
Query: 704 APSTKLQGEVLALEEERAQ-------------VLGHVEQLKVRVKELEQQLQESAREAEM 750
+ + E A ++ A+ L E L++R++ E Q+S +AE
Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630
Query: 751 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF 810
E+ + EREA R KA +Q + E ++K+R + AE + +L + E
Sbjct: 1631 EKQKEEAEREARR-----RGKAEEQAVRQRELAEQELEKQR-QLAEG-TAQQRLAAEQEL 1683
Query: 811 QQLERES-RVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERL 869
+L E+ + E++R+L + L R + E + KR+E L+++ ++RA+
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE----LEAELAKVRAEMEVLLASK 1739
Query: 870 ARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRT 929
AR + S +K K++L R+ L + + +E R + E + R
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFREL--AEEAARLRALAEEAKRQRQLAEEDAARQRA 1797
Query: 930 RSGPLPSSSGSSSSSSQLSVATLGRSPSPKS----ALLTQNGTGSLPRNLAATLQDIETK 985
+ + + +A +G + K+ AL + R LA + E
Sbjct: 1798 EAERVLAE----------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA----EDEAF 1843
Query: 986 RQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL 1045
++ L+++ Q + RLA+L++ + +E + Q +
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------------------- 1884
Query: 1046 HHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE--- 1102
L R+ EE + ++ E + G + + D + S ++
Sbjct: 1885 --LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1942
Query: 1103 ---EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVE------RRLQSESAR 1153
E E+ +EA + + + E R+ ALEE R + +VE R + ESAR
Sbjct: 1943 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2002
Query: 1154 RQQLVEKEVKMR 1165
+ QL ++ + R
Sbjct: 2003 QLQLAQEAAQKR 2014
Score = 70.1 bits (170), Expect = 1e-11
Identities = 133/640 (20%), Positives = 256/640 (40%), Gaps = 103/640 (16%)
Query: 591 EYHRRQRQERLR-----EQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
E RR+ +ER++ E+E R + LE + L A+ A E E S + A
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007
Query: 646 LALAGRR-PSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDA 704
A +R + A A +E Q L +++++ ++ L + E+ ++ E+A
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKE-----QELQQTLQQ-EQSVLDQLRGEAEAARRAAEEA 2061
Query: 705 PSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAR-EAEMERALLQGEREAER 763
++Q E E AQ VE+ + + E+Q Q A+ +A E+ + E+EA R
Sbjct: 2062 EEARVQAE-----REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 764 ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEER 823
Q EQ A+ Q Q A + ++K + + L + ++ ++L +L+ E + ++
Sbjct: 2117 RA-QAEQAALRQKQ----AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-TDHQK 2170
Query: 824 ELAGQGLLRSKAELLRSIAKRKE------RLAILDSQAGQIRAQAVQESERLA-RDKNAS 876
L + L R KAE + +R + + + + +++A+ E+ L RDK+ +
Sbjct: 2171 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2230
Query: 877 LQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPS 936
+ LQ+E EK+ +E R + + + L + L
Sbjct: 2231 QRFLQEEAEKMK-------------------QVAEEAARLSVAAQEAARLRQLAEEDLAQ 2271
Query: 937 SSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETK--RQLALQQKG 994
+ + + + + K+ L + A LQ+ + + +QLA + +G
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2331
Query: 995 -QQVIEEQRRRLAE-------LKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL- 1045
Q+ +E +R+R E LK + A ++ Q A A F +H + L
Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2391
Query: 1046 -------------------HHLPAGRERGEEGEHAYDTLSLES------SDSMETSISTG 1080
H RE E E + L E+ S+ M+T
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----- 2446
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAH---AEKNRLMESREREMELRRQALEEER 1137
+ L + E + +L+ EK +L + + E+ +Q EE++
Sbjct: 2447 ---VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2503
Query: 1138 RRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQ 1171
R+++Q+E+ Q E+ RRQ E+ V+ ++++ Q
Sbjct: 2504 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2543
Score = 69.3 bits (168), Expect = 2e-11
Identities = 144/623 (23%), Positives = 242/623 (38%), Gaps = 84/623 (13%)
Query: 584 DNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEAT 643
+ E+ L E R + +ERL E E LE+QR L ++A EA EL +
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAA-LEKQRQ---LAEAHAQAKAQAEREAKEL----QQR 1364
Query: 644 AALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHED 703
+ R + A RS +E Q+L +S E + ++ ++ S + E+
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421
Query: 704 APSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGERE--- 760
+LQ E A E +R G ++ L+ R +E E Q +++ EAE R +Q E +
Sbjct: 1422 IRVVRLQLE--ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1479
Query: 761 -----------AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE-------ALETET 802
AE +++Q+A+ L+E + E ++ R E E ALET
Sbjct: 1480 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1539
Query: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQA 862
+ E E Q +R S E+ +L + L+ + + + + ER A ++A + R +A
Sbjct: 1540 RSAE-AELQS-KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1595
Query: 863 VQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEA 922
+E ER N +L+L + +E V +++ SL + +E R G+A
Sbjct: 1596 ERELERWQLKANEALRLRLQAEE---VAQQK--SLAQAEAEKQKEEAEREARRR---GKA 1647
Query: 923 TSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL---TQNGTGSLPRNLAATL 979
R R + QL+ T + + + L+ + G R L
Sbjct: 1648 EEQAVRQRE----LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1703
Query: 980 QDIETKRQLALQQKGQQVIEEQRRRLAE----LKQKAAAEAQCQWDALHGAAPFPAGPSG 1035
+ A QK Q++ E + AE L KA AE + + + A
Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1763
Query: 1036 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG 1095
F RE EE L+ E+ + + + + +
Sbjct: 1764 F---------------RELAEEAAR-LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Query: 1096 LDMGKI----EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRL---- 1147
+G+ E E LKE AE RL E E RR+ E+ + + +E RL
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867
Query: 1148 ---QSESARRQQLVEKEVKMREK 1167
SE R++ LVE ++ R +
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQ 1890
Score = 66.2 bits (160), Expect = 2e-10
Identities = 159/722 (22%), Positives = 273/722 (37%), Gaps = 135/722 (18%)
Query: 595 RQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPS 654
R++Q L+ E RL+ + E L AE RA A E + +A L +R S
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQ-AEVERARQVQVALET---AQRSAEAELQSKRAS 1552
Query: 655 RGLAGAS-GRSSEEPGVATQRLWESMER-----SDEENLKEECS-STESTQQEHEDAPST 707
A RS +E VA +L E ER ++ E +EE E Q + +A
Sbjct: 1553 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1612
Query: 708 KLQGEVLALEEERAQV---------------LGHVEQLKVRVKELEQQLQESARE----- 747
+LQ E +A ++ AQ G E+ VR +EL +Q E R+
Sbjct: 1613 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672
Query: 748 ------AEMERALL-----QGER-----EAERALLQKEQKAVDQLQEKLVALETGIQKER 791
AE E L QGE+ E E A LQ+E A Q +++L A ++ E
Sbjct: 1673 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1732
Query: 792 D------------------KEAEALETETKLFEDLEFQQLERESRVEE---ERELAGQGL 830
+ K + LE E F +L + + EE +R+LA +
Sbjct: 1733 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1792
Query: 831 LRSKAELLRSIA------------KRKERLAILDSQAGQIRAQAVQESERLARDK----- 873
R +AE R +A K + +A+ + +A R + + E E R +
Sbjct: 1793 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Query: 874 -----NASLQLLQKEKEKLTVLERRY----HSLTGGRPFPKTTSTLKEVYRSKMDGEATS 924
+ +L Q K + LER+ +L R + LK + G+A
Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1912
Query: 925 PLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIET 984
L R + S ++L A R + + + + ++LAA ++
Sbjct: 1913 ELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAE-EEAAR 1970
Query: 985 KRQLALQQ--KGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLM-- 1040
+R+ AL++ + + +EE RR +Q++A + Q +A F
Sbjct: 1971 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2030
Query: 1041 ---------HHSILHHL----PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP 1087
S+L L A R EE E A E++ S + S
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR-QVEEAERLKQSA 2089
Query: 1088 DNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESR----------EREMELRRQALEEER 1137
+ + A E K+ KEA E R ++ + EME ++ E+
Sbjct: 2090 EEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 1138 RRREQVERRLQS------ESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTH 1191
R++ QVE+ L + E+ ++ L+++E++ + + ++A + + +E F ++
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA--ARQRSQVEEELFSVRVQ 2204
Query: 1192 IE 1193
+E
Sbjct: 2205 ME 2206
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/403 (22%), Positives = 163/403 (40%), Gaps = 73/403 (18%)
Query: 554 QSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQR 613
Q V+++L++ L++ T +KN + E RQR + E R++ +
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Query: 614 LETILNLCAEYSRA------DGGP-----EAGELPSIGEATAALALAGRRPSRGLAGASG 662
L + +RA D EA ++ + E A L++A + +R A
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
+++ +A + L E M+ E + + Q+E + +LQ + +E+ AQ
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED----KEQMAQ 2323
Query: 723 VLGHVEQLKVRVKELEQQ--LQESA-------REAEMERALLQGEREAERALLQKEQKAV 773
L Q R E E+Q L+ SA R AEM RA + E +A+R +K
Sbjct: 2324 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----RKQA 2378
Query: 774 DQLQEKLVALETGIQK---------------------------ERDKEAEALETETKLFE 806
+++ EKL E Q+ E ++E E L+ E KL +
Sbjct: 2379 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2438
Query: 807 --DLEFQQLERESRVEEERELAGQGLLRSKAELL---RSIAKRKERLAILDSQAGQIRAQ 861
E Q +++E ++E + L Q L K LL R I + K +L Q+
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERFIEQEKAKLE-------QLFQD 2490
Query: 862 AVQESERLARDKNASLQLLQKEKEKLTV----LERRYHSLTGG 900
V ++++L ++ Q +++E+++L RR H G
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533
Score = 53.9 bits (128), Expect = 1e-06
Identities = 80/317 (25%), Positives = 133/317 (41%), Gaps = 57/317 (17%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEA 633
ER + + SD+E +RQ+ L E + R RQ E IL L A + +A G
Sbjct: 1861 ERLAQLRKASDSE--------LERQKGLVEDTL-RQRRQVEEEILALKASFEKAAAGKAE 1911
Query: 634 GELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSS 693
EL GR S + E A QR + E
Sbjct: 1912 LELE-----------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEE------------- 1947
Query: 694 TESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERA 753
E ++E E+ L E A + +A L VE+LK +V+E ++L+E A
Sbjct: 1948 -ERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEA-RRLRERA-------- 1996
Query: 754 LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQ-- 811
E+E+ R L ++ A +LQ + A +Q++ + + L+ E + + L +
Sbjct: 1997 ----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2052
Query: 812 ------QLERESRVEEERELAGQGLLRSKAELLRSIAKRK-ERLAILDSQAGQIRAQAVQ 864
+ E+RV+ ERE A +AE L+ A+ + + A + A ++R +A Q
Sbjct: 2053 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112
Query: 865 ESERLARDKNASLQLLQ 881
E+ R A+ + A+L+ Q
Sbjct: 2113 EAARRAQAEQAALRQKQ 2129
Score = 49.7 bits (117), Expect = 2e-05
Identities = 100/481 (20%), Positives = 195/481 (40%), Gaps = 76/481 (15%)
Query: 718 EERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQ-KAVDQL 776
+E+ Q + + VR EQ QE A E+ER GE+ E K+ A+
Sbjct: 1198 QEQIQAMPLADSQAVR----EQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1250
Query: 777 QEKLVALETGIQK-----ERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
+ +LV + ++ ++ K E+ + + DL E + + + + L
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1310
Query: 832 RSKAE---LLRSIAKRKERLAILDS------QAGQIRAQAVQESERLARDKNASLQ--LL 880
R + E + A+ +ERLA +++ Q + AQA ++ER A++ +Q ++
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 881 QKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGS 940
++E+ + +++ R + L++ +++ +A RS
Sbjct: 1371 RREEAAVDAQQQK-------RSIQEELQQLRQSSEAEIQAKARQAEAAERS--------R 1415
Query: 941 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQ----KGQQ 996
++ V L + + + G + L A ++ E +++ A ++ + Q
Sbjct: 1416 LRIEEEIRVVRLQLEATERQ----RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1471
Query: 997 VIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGE 1056
E QR+R AE++ + +A+ + A L L R + E
Sbjct: 1472 QDESQRKRQAEVELASRVKAEAEAAREKQRA-----------------LQALEELRLQAE 1514
Query: 1057 EGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKN 1116
E E +E + ++ ++ T SA + AS + K ++E+ L+E H
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQLERSLQEEHVAVA 1572
Query: 1117 RLMESREREMELRRQALEEERRRREQVER-----RLQSESARRQQLVEKEVKMREKQFSQ 1171
+L E ER R Q E R RE+ ER +L++ A R +L +EV ++K +Q
Sbjct: 1573 QLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV-AQQKSLAQ 1627
Query: 1172 A 1172
A
Sbjct: 1628 A 1628
Score = 35.8 bits (81), Expect = 0.28
Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVE 1159
++EE E++ ++ AE+ + E +E +RQ E + + Q ER E+ QQ ++
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER----EAKELQQRMQ 1366
Query: 1160 KEVKMREKQFSQARPLTR 1177
+EV RE+ A+ R
Sbjct: 1367 EEVVRREEAAVDAQQQKR 1384
Score = 32.7 bits (73), Expect = 2.4
Identities = 72/333 (21%), Positives = 131/333 (39%), Gaps = 50/333 (15%)
Query: 568 RVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRA 627
R + + K ++ + + + ++ + +E + E E E+ + Q+ +L L +E
Sbjct: 2387 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-- 2444
Query: 628 DGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENL 687
+ + + + T AL + L R E+ ++L++ E + + L
Sbjct: 2445 ----QTVQQEQLLQETQALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQD-EVAKAQQL 2498
Query: 688 KEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESARE 747
+EE QQ + + Q V ++EE R + H + VR K+ E Q E R
Sbjct: 2499 REE-------QQRQQQQMEQERQRLVASMEEARRR--QHEAEEGVRRKQEELQQLEQQRR 2549
Query: 748 AEMERALLQGEREAER-ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFE 806
+ E + +R E+ LL+++ +A E++ A + K +AL+
Sbjct: 2550 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA---- 2605
Query: 807 DLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQES 866
E E E + GL R + A+R + IL ++ Q AQ
Sbjct: 2606 ------------AEAEPEHSFDGLRRKVS------AQRLQEAGILSAEELQRLAQGHTTV 2647
Query: 867 ERLAR--DKNASLQ--------LLQKEKEKLTV 889
+ LAR D LQ LL+ EKL+V
Sbjct: 2648 DELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2680
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/628 (22%), Positives = 252/628 (40%), Gaps = 82/628 (13%)
Query: 600 RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAG 659
R R +E E +RQ E L + E+ + A A A R R L
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV-ELASRVKAEAEAAREKQRAL-- 1672
Query: 660 ASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEE 719
++ EE + + + +++ E ++ + E+ Q+ E +LQ + + E+
Sbjct: 1673 ---QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE----AELQSKRASFAEK 1725
Query: 720 RAQVLGHVEQLKVRVKELEQQLQESARE-AEMERALLQGEREAERALLQKEQKAVDQLQE 778
AQ+ +++ V V +L ++ + A++ AE ERA + ERE ER L+ + +LQ
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785
Query: 779 KLVALETGI-QKERDKEAEALETETKLFEDLEFQQLER----ESRVEEERELA---GQGL 830
+ VA + + Q E +K+ E E E + E Q + + E +E++R+LA Q
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845
Query: 831 LRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVL 890
L ++ EL+R A+ + Q Q R +E RL R+ A+ Q Q+ + +L +
Sbjct: 1846 LAAEQELIRLRAETE--------QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1897
Query: 891 ERRYHSLTGGRPFPKTTS-TLKEVYRSKMDGEATSPLPRTRSGP-LPSSSGSSSSSSQLS 948
L + + S + E + +++ EA L + + + QL+
Sbjct: 1898 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1957
Query: 949 VATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE---QRRRL 1005
R + +L + T +I K + A ++ +++ E+ QRRRL
Sbjct: 1958 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 2017
Query: 1006 AELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTL 1065
E + A+ + + L A+ ++ R + EE + L
Sbjct: 2018 EEQAAQHKADIEERLAQLRKASDSELE-------RQKGLVEDTLRQRRQVEE-----EIL 2065
Query: 1066 SLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE-EMEKMLKEAHAEKN-RLMESRE 1123
+L++S + GK E E+E ++AE R E E
Sbjct: 2066 ALKASFEKAAA----------------------GKAELELELGRIRSNAEDTLRSKEQAE 2103
Query: 1124 REMELRRQALEEERRRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQARPL-- 1175
E +RQ EE RRR + E R+Q E+AR+++ +EV+ + + +AR L
Sbjct: 2104 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163
Query: 1176 ------TRYLPIRKEDFDLKTHIESSGH 1197
R L + +E + E H
Sbjct: 2164 RAEQESARQLQLAQEAAQKRLQAEEKAH 2191
Score = 70.5 bits (171), Expect = 1e-11
Identities = 132/612 (21%), Positives = 241/612 (39%), Gaps = 88/612 (14%)
Query: 591 EYHRRQRQE---RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALA 647
E +RQ QE RLR Q + +R+R + + A+ A E +A L
Sbjct: 1623 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQRALQALEELR 1679
Query: 648 LAGRRPSRGLAGASGRSSEEPGVA---TQRLWESMERSDEENLKEECSSTE-STQQEHED 703
L R L A + + VA QR E+ +S + E+ + E S Q+EH
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1739
Query: 704 APSTKLQGEVLALEEERAQ-------------VLGHVEQLKVRVKELEQQLQESAREAEM 750
+ + E A ++ A+ L E L++R++ E Q+S +AE
Sbjct: 1740 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799
Query: 751 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF 810
E+ + EREA R KA +Q + E ++K+R + AE + +L + E
Sbjct: 1800 EKQKEEAEREARR-----RGKAEEQAVRQRELAEQELEKQR-QLAEG-TAQQRLAAEQEL 1852
Query: 811 QQLERES-RVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERL 869
+L E+ + E++R+L + L R + E + KR+E L+++ ++RA+
Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE----LEAELAKVRAEMEVLLASK 1908
Query: 870 ARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRT 929
AR + S +K K++L R+ L + + +E R + E + R
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFREL--AEEAARLRALAEEAKRQRQLAEEDAARQRA 1966
Query: 930 RSGPLPSSSGSSSSSSQLSVATLGRSPSPKS----ALLTQNGTGSLPRNLAATLQDIETK 985
+ + + +A +G + K+ AL + R LA + E
Sbjct: 1967 EAERVLAE----------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA----EDEAF 2012
Query: 986 RQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL 1045
++ L+++ Q + RLA+L++ + +E + Q +
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------------------- 2053
Query: 1046 HHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE--- 1102
L R+ EE + ++ E + G + + D + S ++
Sbjct: 2054 --LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2111
Query: 1103 ---EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVE------RRLQSESAR 1153
E E+ +EA + + + E R+ ALEE R + +VE R + ESAR
Sbjct: 2112 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2171
Query: 1154 RQQLVEKEVKMR 1165
+ QL ++ + R
Sbjct: 2172 QLQLAQEAAQKR 2183
Score = 70.1 bits (170), Expect = 1e-11
Identities = 133/640 (20%), Positives = 256/640 (40%), Gaps = 103/640 (16%)
Query: 591 EYHRRQRQERLR-----EQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
E RR+ +ER++ E+E R + LE + L A+ A E E S + A
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176
Query: 646 LALAGRR-PSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDA 704
A +R + A A +E Q L +++++ ++ L + E+ ++ E+A
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKE-----QELQQTLQQ-EQSVLDQLRGEAEAARRAAEEA 2230
Query: 705 PSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAR-EAEMERALLQGEREAER 763
++Q E E AQ VE+ + + E+Q Q A+ +A E+ + E+EA R
Sbjct: 2231 EEARVQAE-----REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 764 ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEER 823
Q EQ A+ Q Q A + ++K + + L + ++ ++L +L+ E + ++
Sbjct: 2286 RA-QAEQAALRQKQ----AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-TDHQK 2339
Query: 824 ELAGQGLLRSKAELLRSIAKRKE------RLAILDSQAGQIRAQAVQESERLA-RDKNAS 876
L + L R KAE + +R + + + + +++A+ E+ L RDK+ +
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2399
Query: 877 LQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPS 936
+ LQ+E EK+ +E R + + + L + L
Sbjct: 2400 QRFLQEEAEKMK-------------------QVAEEAARLSVAAQEAARLRQLAEEDLAQ 2440
Query: 937 SSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETK--RQLALQQKG 994
+ + + + + K+ L + A LQ+ + + +QLA + +G
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2500
Query: 995 -QQVIEEQRRRLAE-------LKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL- 1045
Q+ +E +R+R E LK + A ++ Q A A F +H + L
Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2560
Query: 1046 -------------------HHLPAGRERGEEGEHAYDTLSLES------SDSMETSISTG 1080
H RE E E + L E+ S+ M+T
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----- 2615
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAH---AEKNRLMESREREMELRRQALEEER 1137
+ L + E + +L+ EK +L + + E+ +Q EE++
Sbjct: 2616 ---VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2672
Query: 1138 RRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQ 1171
R+++Q+E+ Q E+ RRQ E+ V+ ++++ Q
Sbjct: 2673 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2712
Score = 69.3 bits (168), Expect = 2e-11
Identities = 144/623 (23%), Positives = 242/623 (38%), Gaps = 84/623 (13%)
Query: 584 DNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEAT 643
+ E+ L E R + +ERL E E LE+QR L ++A EA EL +
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAA-LEKQRQ---LAEAHAQAKAQAEREAKEL----QQR 1533
Query: 644 AALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHED 703
+ R + A RS +E Q+L +S E + ++ ++ S + E+
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590
Query: 704 APSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGERE--- 760
+LQ E A E +R G ++ L+ R +E E Q +++ EAE R +Q E +
Sbjct: 1591 IRVVRLQLE--ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1648
Query: 761 -----------AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE-------ALETET 802
AE +++Q+A+ L+E + E ++ R E E ALET
Sbjct: 1649 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1708
Query: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQA 862
+ E E Q +R S E+ +L + L+ + + + + ER A ++A + R +A
Sbjct: 1709 RSAE-AELQS-KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1764
Query: 863 VQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEA 922
+E ER N +L+L + +E V +++ SL + +E R G+A
Sbjct: 1765 ERELERWQLKANEALRLRLQAEE---VAQQK--SLAQAEAEKQKEEAEREARRR---GKA 1816
Query: 923 TSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL---TQNGTGSLPRNLAATL 979
R R + QL+ T + + + L+ + G R L
Sbjct: 1817 EEQAVRQRE----LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1872
Query: 980 QDIETKRQLALQQKGQQVIEEQRRRLAE----LKQKAAAEAQCQWDALHGAAPFPAGPSG 1035
+ A QK Q++ E + AE L KA AE + + + A
Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1932
Query: 1036 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG 1095
F RE EE L+ E+ + + + + +
Sbjct: 1933 F---------------RELAEEAAR-LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Query: 1096 LDMGKI----EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRL---- 1147
+G+ E E LKE AE RL E E RR+ E+ + + +E RL
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036
Query: 1148 ---QSESARRQQLVEKEVKMREK 1167
SE R++ LVE ++ R +
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQ 2059
Score = 66.2 bits (160), Expect = 2e-10
Identities = 159/722 (22%), Positives = 273/722 (37%), Gaps = 135/722 (18%)
Query: 595 RQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPS 654
R++Q L+ E RL+ + E L AE RA A E + +A L +R S
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQ-AEVERARQVQVALET---AQRSAEAELQSKRAS 1721
Query: 655 RGLAGAS-GRSSEEPGVATQRLWESMER-----SDEENLKEECS-STESTQQEHEDAPST 707
A RS +E VA +L E ER ++ E +EE E Q + +A
Sbjct: 1722 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1781
Query: 708 KLQGEVLALEEERAQV---------------LGHVEQLKVRVKELEQQLQESARE----- 747
+LQ E +A ++ AQ G E+ VR +EL +Q E R+
Sbjct: 1782 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841
Query: 748 ------AEMERALL-----QGER-----EAERALLQKEQKAVDQLQEKLVALETGIQKER 791
AE E L QGE+ E E A LQ+E A Q +++L A ++ E
Sbjct: 1842 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1901
Query: 792 D------------------KEAEALETETKLFEDLEFQQLERESRVEE---ERELAGQGL 830
+ K + LE E F +L + + EE +R+LA +
Sbjct: 1902 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1961
Query: 831 LRSKAELLRSIA------------KRKERLAILDSQAGQIRAQAVQESERLARDK----- 873
R +AE R +A K + +A+ + +A R + + E E R +
Sbjct: 1962 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Query: 874 -----NASLQLLQKEKEKLTVLERRY----HSLTGGRPFPKTTSTLKEVYRSKMDGEATS 924
+ +L Q K + LER+ +L R + LK + G+A
Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 2081
Query: 925 PLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIET 984
L R + S ++L A R + + + + ++LAA ++
Sbjct: 2082 ELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAE-EEAAR 2139
Query: 985 KRQLALQQ--KGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLM-- 1040
+R+ AL++ + + +EE RR +Q++A + Q +A F
Sbjct: 2140 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199
Query: 1041 ---------HHSILHHL----PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP 1087
S+L L A R EE E A E++ S + S
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR-QVEEAERLKQSA 2258
Query: 1088 DNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESR----------EREMELRRQALEEER 1137
+ + A E K+ KEA E R ++ + EME ++ E+
Sbjct: 2259 EEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 1138 RRREQVERRLQS------ESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTH 1191
R++ QVE+ L + E+ ++ L+++E++ + + ++A + + +E F ++
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA--ARQRSQVEEELFSVRVQ 2373
Query: 1192 IE 1193
+E
Sbjct: 2374 ME 2375
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/403 (22%), Positives = 163/403 (40%), Gaps = 73/403 (18%)
Query: 554 QSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQR 613
Q V+++L++ L++ T +KN + E RQR + E R++ +
Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Query: 614 LETILNLCAEYSRA------DGGP-----EAGELPSIGEATAALALAGRRPSRGLAGASG 662
L + +RA D EA ++ + E A L++A + +R A
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
+++ +A + L E M+ E + + Q+E + +LQ + +E+ AQ
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED----KEQMAQ 2492
Query: 723 VLGHVEQLKVRVKELEQQ--LQESA-------REAEMERALLQGEREAERALLQKEQKAV 773
L Q R E E+Q L+ SA R AEM RA + E +A+R +K
Sbjct: 2493 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----RKQA 2547
Query: 774 DQLQEKLVALETGIQK---------------------------ERDKEAEALETETKLFE 806
+++ EKL E Q+ E ++E E L+ E KL +
Sbjct: 2548 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2607
Query: 807 --DLEFQQLERESRVEEERELAGQGLLRSKAELL---RSIAKRKERLAILDSQAGQIRAQ 861
E Q +++E ++E + L Q L K LL R I + K +L Q+
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERFIEQEKAKLE-------QLFQD 2659
Query: 862 AVQESERLARDKNASLQLLQKEKEKLTV----LERRYHSLTGG 900
V ++++L ++ Q +++E+++L RR H G
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702
Score = 53.9 bits (128), Expect = 1e-06
Identities = 80/317 (25%), Positives = 133/317 (41%), Gaps = 57/317 (17%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEA 633
ER + + SD+E +RQ+ L E + R RQ E IL L A + +A G
Sbjct: 2030 ERLAQLRKASDSE--------LERQKGLVEDTL-RQRRQVEEEILALKASFEKAAAGKAE 2080
Query: 634 GELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSS 693
EL GR S + E A QR + E
Sbjct: 2081 LELE-----------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEE------------- 2116
Query: 694 TESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERA 753
E ++E E+ L E A + +A L VE+LK +V+E ++L+E A
Sbjct: 2117 -ERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEA-RRLRERA-------- 2165
Query: 754 LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQ-- 811
E+E+ R L ++ A +LQ + A +Q++ + + L+ E + + L +
Sbjct: 2166 ----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221
Query: 812 ------QLERESRVEEERELAGQGLLRSKAELLRSIAKRK-ERLAILDSQAGQIRAQAVQ 864
+ E+RV+ ERE A +AE L+ A+ + + A + A ++R +A Q
Sbjct: 2222 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281
Query: 865 ESERLARDKNASLQLLQ 881
E+ R A+ + A+L+ Q
Sbjct: 2282 EAARRAQAEQAALRQKQ 2298
Score = 49.7 bits (117), Expect = 2e-05
Identities = 100/481 (20%), Positives = 195/481 (40%), Gaps = 76/481 (15%)
Query: 718 EERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQ-KAVDQL 776
+E+ Q + + VR EQ QE A E+ER GE+ E K+ A+
Sbjct: 1367 QEQIQAMPLADSQAVR----EQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1419
Query: 777 QEKLVALETGIQK-----ERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
+ +LV + ++ ++ K E+ + + DL E + + + + L
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1479
Query: 832 RSKAE---LLRSIAKRKERLAILDS------QAGQIRAQAVQESERLARDKNASLQ--LL 880
R + E + A+ +ERLA +++ Q + AQA ++ER A++ +Q ++
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 881 QKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGS 940
++E+ + +++ R + L++ +++ +A RS
Sbjct: 1540 RREEAAVDAQQQK-------RSIQEELQQLRQSSEAEIQAKARQAEAAERS--------R 1584
Query: 941 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQ----KGQQ 996
++ V L + + + G + L A ++ E +++ A ++ + Q
Sbjct: 1585 LRIEEEIRVVRLQLEATERQ----RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1640
Query: 997 VIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGE 1056
E QR+R AE++ + +A+ + A L L R + E
Sbjct: 1641 QDESQRKRQAEVELASRVKAEAEAAREKQRA-----------------LQALEELRLQAE 1683
Query: 1057 EGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKN 1116
E E +E + ++ ++ T SA + AS + K ++E+ L+E H
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQLERSLQEEHVAVA 1741
Query: 1117 RLMESREREMELRRQALEEERRRREQVER-----RLQSESARRQQLVEKEVKMREKQFSQ 1171
+L E ER R Q E R RE+ ER +L++ A R +L +EV ++K +Q
Sbjct: 1742 QLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV-AQQKSLAQ 1796
Query: 1172 A 1172
A
Sbjct: 1797 A 1797
Score = 35.8 bits (81), Expect = 0.28
Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVE 1159
++EE E++ ++ AE+ + E +E +RQ E + + Q ER E+ QQ ++
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER----EAKELQQRMQ 1535
Query: 1160 KEVKMREKQFSQARPLTR 1177
+EV RE+ A+ R
Sbjct: 1536 EEVVRREEAAVDAQQQKR 1553
Score = 32.7 bits (73), Expect = 2.4
Identities = 72/333 (21%), Positives = 131/333 (39%), Gaps = 50/333 (15%)
Query: 568 RVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRA 627
R + + K ++ + + + ++ + +E + E E E+ + Q+ +L L +E
Sbjct: 2556 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-- 2613
Query: 628 DGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENL 687
+ + + + T AL + L R E+ ++L++ E + + L
Sbjct: 2614 ----QTVQQEQLLQETQALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQD-EVAKAQQL 2667
Query: 688 KEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESARE 747
+EE QQ + + Q V ++EE R + H + VR K+ E Q E R
Sbjct: 2668 REE-------QQRQQQQMEQERQRLVASMEEARRR--QHEAEEGVRRKQEELQQLEQQRR 2718
Query: 748 AEMERALLQGEREAER-ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFE 806
+ E + +R E+ LL+++ +A E++ A + K +AL+
Sbjct: 2719 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA---- 2774
Query: 807 DLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQES 866
E E E + GL R + A+R + IL ++ Q AQ
Sbjct: 2775 ------------AEAEPEHSFDGLRRKVS------AQRLQEAGILSAEELQRLAQGHTTV 2816
Query: 867 ERLAR--DKNASLQ--------LLQKEKEKLTV 889
+ LAR D LQ LL+ EKL+V
Sbjct: 2817 DELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2849
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/628 (22%), Positives = 252/628 (40%), Gaps = 82/628 (13%)
Query: 600 RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAG 659
R R +E E +RQ E L + E+ + A A A R R L
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV-ELASRVKAEAEAAREKQRAL-- 1513
Query: 660 ASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEE 719
++ EE + + + +++ E ++ + E+ Q+ E +LQ + + E+
Sbjct: 1514 ---QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE----AELQSKRASFAEK 1566
Query: 720 RAQVLGHVEQLKVRVKELEQQLQESARE-AEMERALLQGEREAERALLQKEQKAVDQLQE 778
AQ+ +++ V V +L ++ + A++ AE ERA + ERE ER L+ + +LQ
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626
Query: 779 KLVALETGI-QKERDKEAEALETETKLFEDLEFQQLER----ESRVEEERELA---GQGL 830
+ VA + + Q E +K+ E E E + E Q + + E +E++R+LA Q
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686
Query: 831 LRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVL 890
L ++ EL+R A+ + Q Q R +E RL R+ A+ Q Q+ + +L +
Sbjct: 1687 LAAEQELIRLRAETE--------QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1738
Query: 891 ERRYHSLTGGRPFPKTTS-TLKEVYRSKMDGEATSPLPRTRSGP-LPSSSGSSSSSSQLS 948
L + + S + E + +++ EA L + + + QL+
Sbjct: 1739 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1798
Query: 949 VATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE---QRRRL 1005
R + +L + T +I K + A ++ +++ E+ QRRRL
Sbjct: 1799 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1858
Query: 1006 AELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTL 1065
E + A+ + + L A+ ++ R + EE + L
Sbjct: 1859 EEQAAQHKADIEERLAQLRKASDSELE-------RQKGLVEDTLRQRRQVEE-----EIL 1906
Query: 1066 SLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE-EMEKMLKEAHAEKN-RLMESRE 1123
+L++S + GK E E+E ++AE R E E
Sbjct: 1907 ALKASFEKAAA----------------------GKAELELELGRIRSNAEDTLRSKEQAE 1944
Query: 1124 REMELRRQALEEERRRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQARPL-- 1175
E +RQ EE RRR + E R+Q E+AR+++ +EV+ + + +AR L
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004
Query: 1176 ------TRYLPIRKEDFDLKTHIESSGH 1197
R L + +E + E H
Sbjct: 2005 RAEQESARQLQLAQEAAQKRLQAEEKAH 2032
Score = 70.5 bits (171), Expect = 1e-11
Identities = 132/612 (21%), Positives = 241/612 (39%), Gaps = 88/612 (14%)
Query: 591 EYHRRQRQE---RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALA 647
E +RQ QE RLR Q + +R+R + + A+ A E +A L
Sbjct: 1464 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQRALQALEELR 1520
Query: 648 LAGRRPSRGLAGASGRSSEEPGVA---TQRLWESMERSDEENLKEECSSTE-STQQEHED 703
L R L A + + VA QR E+ +S + E+ + E S Q+EH
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1580
Query: 704 APSTKLQGEVLALEEERAQ-------------VLGHVEQLKVRVKELEQQLQESAREAEM 750
+ + E A ++ A+ L E L++R++ E Q+S +AE
Sbjct: 1581 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640
Query: 751 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF 810
E+ + EREA R KA +Q + E ++K+R + AE + +L + E
Sbjct: 1641 EKQKEEAEREARR-----RGKAEEQAVRQRELAEQELEKQR-QLAEG-TAQQRLAAEQEL 1693
Query: 811 QQLERES-RVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERL 869
+L E+ + E++R+L + L R + E + KR+E L+++ ++RA+
Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE----LEAELAKVRAEMEVLLASK 1749
Query: 870 ARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRT 929
AR + S +K K++L R+ L + + +E R + E + R
Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFREL--AEEAARLRALAEEAKRQRQLAEEDAARQRA 1807
Query: 930 RSGPLPSSSGSSSSSSQLSVATLGRSPSPKS----ALLTQNGTGSLPRNLAATLQDIETK 985
+ + + +A +G + K+ AL + R LA + E
Sbjct: 1808 EAERVLAE----------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA----EDEAF 1853
Query: 986 RQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL 1045
++ L+++ Q + RLA+L++ + +E + Q +
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------------------- 1894
Query: 1046 HHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE--- 1102
L R+ EE + ++ E + G + + D + S ++
Sbjct: 1895 --LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1952
Query: 1103 ---EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVE------RRLQSESAR 1153
E E+ +EA + + + E R+ ALEE R + +VE R + ESAR
Sbjct: 1953 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2012
Query: 1154 RQQLVEKEVKMR 1165
+ QL ++ + R
Sbjct: 2013 QLQLAQEAAQKR 2024
Score = 70.1 bits (170), Expect = 1e-11
Identities = 133/640 (20%), Positives = 256/640 (40%), Gaps = 103/640 (16%)
Query: 591 EYHRRQRQERLR-----EQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
E RR+ +ER++ E+E R + LE + L A+ A E E S + A
Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2017
Query: 646 LALAGRR-PSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDA 704
A +R + A A +E Q L +++++ ++ L + E+ ++ E+A
Sbjct: 2018 QEAAQKRLQAEEKAHAFAVQQKE-----QELQQTLQQ-EQSVLDQLRGEAEAARRAAEEA 2071
Query: 705 PSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAR-EAEMERALLQGEREAER 763
++Q E E AQ VE+ + + E+Q Q A+ +A E+ + E+EA R
Sbjct: 2072 EEARVQAE-----REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 764 ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEER 823
Q EQ A+ Q Q A + ++K + + L + ++ ++L +L+ E + ++
Sbjct: 2127 RA-QAEQAALRQKQ----AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-TDHQK 2180
Query: 824 ELAGQGLLRSKAELLRSIAKRKE------RLAILDSQAGQIRAQAVQESERLA-RDKNAS 876
L + L R KAE + +R + + + + +++A+ E+ L RDK+ +
Sbjct: 2181 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2240
Query: 877 LQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPS 936
+ LQ+E EK+ +E R + + + L + L
Sbjct: 2241 QRFLQEEAEKMK-------------------QVAEEAARLSVAAQEAARLRQLAEEDLAQ 2281
Query: 937 SSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETK--RQLALQQKG 994
+ + + + + K+ L + A LQ+ + + +QLA + +G
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341
Query: 995 -QQVIEEQRRRLAE-------LKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL- 1045
Q+ +E +R+R E LK + A ++ Q A A F +H + L
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2401
Query: 1046 -------------------HHLPAGRERGEEGEHAYDTLSLES------SDSMETSISTG 1080
H RE E E + L E+ S+ M+T
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----- 2456
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAH---AEKNRLMESREREMELRRQALEEER 1137
+ L + E + +L+ EK +L + + E+ +Q EE++
Sbjct: 2457 ---VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2513
Query: 1138 RRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQ 1171
R+++Q+E+ Q E+ RRQ E+ V+ ++++ Q
Sbjct: 2514 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2553
Score = 69.3 bits (168), Expect = 2e-11
Identities = 144/623 (23%), Positives = 242/623 (38%), Gaps = 84/623 (13%)
Query: 584 DNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEAT 643
+ E+ L E R + +ERL E E LE+QR L ++A EA EL +
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAA-LEKQRQ---LAEAHAQAKAQAEREAKEL----QQR 1374
Query: 644 AALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHED 703
+ R + A RS +E Q+L +S E + ++ ++ S + E+
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431
Query: 704 APSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGERE--- 760
+LQ E A E +R G ++ L+ R +E E Q +++ EAE R +Q E +
Sbjct: 1432 IRVVRLQLE--ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1489
Query: 761 -----------AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE-------ALETET 802
AE +++Q+A+ L+E + E ++ R E E ALET
Sbjct: 1490 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1549
Query: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQA 862
+ E E Q +R S E+ +L + L+ + + + + ER A ++A + R +A
Sbjct: 1550 RSAE-AELQS-KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1605
Query: 863 VQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEA 922
+E ER N +L+L + +E V +++ SL + +E R G+A
Sbjct: 1606 ERELERWQLKANEALRLRLQAEE---VAQQK--SLAQAEAEKQKEEAEREARRR---GKA 1657
Query: 923 TSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL---TQNGTGSLPRNLAATL 979
R R + QL+ T + + + L+ + G R L
Sbjct: 1658 EEQAVRQRE----LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1713
Query: 980 QDIETKRQLALQQKGQQVIEEQRRRLAE----LKQKAAAEAQCQWDALHGAAPFPAGPSG 1035
+ A QK Q++ E + AE L KA AE + + + A
Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1773
Query: 1036 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG 1095
F RE EE L+ E+ + + + + +
Sbjct: 1774 F---------------RELAEEAAR-LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Query: 1096 LDMGKI----EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRL---- 1147
+G+ E E LKE AE RL E E RR+ E+ + + +E RL
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877
Query: 1148 ---QSESARRQQLVEKEVKMREK 1167
SE R++ LVE ++ R +
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQ 1900
Score = 66.2 bits (160), Expect = 2e-10
Identities = 159/722 (22%), Positives = 273/722 (37%), Gaps = 135/722 (18%)
Query: 595 RQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPS 654
R++Q L+ E RL+ + E L AE RA A E + +A L +R S
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQ-AEVERARQVQVALET---AQRSAEAELQSKRAS 1562
Query: 655 RGLAGAS-GRSSEEPGVATQRLWESMER-----SDEENLKEECS-STESTQQEHEDAPST 707
A RS +E VA +L E ER ++ E +EE E Q + +A
Sbjct: 1563 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1622
Query: 708 KLQGEVLALEEERAQV---------------LGHVEQLKVRVKELEQQLQESARE----- 747
+LQ E +A ++ AQ G E+ VR +EL +Q E R+
Sbjct: 1623 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682
Query: 748 ------AEMERALL-----QGER-----EAERALLQKEQKAVDQLQEKLVALETGIQKER 791
AE E L QGE+ E E A LQ+E A Q +++L A ++ E
Sbjct: 1683 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1742
Query: 792 D------------------KEAEALETETKLFEDLEFQQLERESRVEE---ERELAGQGL 830
+ K + LE E F +L + + EE +R+LA +
Sbjct: 1743 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1802
Query: 831 LRSKAELLRSIA------------KRKERLAILDSQAGQIRAQAVQESERLARDK----- 873
R +AE R +A K + +A+ + +A R + + E E R +
Sbjct: 1803 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862
Query: 874 -----NASLQLLQKEKEKLTVLERRY----HSLTGGRPFPKTTSTLKEVYRSKMDGEATS 924
+ +L Q K + LER+ +L R + LK + G+A
Sbjct: 1863 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1922
Query: 925 PLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIET 984
L R + S ++L A R + + + + ++LAA ++
Sbjct: 1923 ELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAE-EEAAR 1980
Query: 985 KRQLALQQ--KGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLM-- 1040
+R+ AL++ + + +EE RR +Q++A + Q +A F
Sbjct: 1981 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
Query: 1041 ---------HHSILHHL----PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP 1087
S+L L A R EE E A E++ S + S
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR-QVEEAERLKQSA 2099
Query: 1088 DNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESR----------EREMELRRQALEEER 1137
+ + A E K+ KEA E R ++ + EME ++ E+
Sbjct: 2100 EEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Query: 1138 RRREQVERRLQS------ESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTH 1191
R++ QVE+ L + E+ ++ L+++E++ + + ++A + + +E F ++
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA--ARQRSQVEEELFSVRVQ 2214
Query: 1192 IE 1193
+E
Sbjct: 2215 ME 2216
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/403 (22%), Positives = 163/403 (40%), Gaps = 73/403 (18%)
Query: 554 QSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQR 613
Q V+++L++ L++ T +KN + E RQR + E R++ +
Sbjct: 2158 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
Query: 614 LETILNLCAEYSRA------DGGP-----EAGELPSIGEATAALALAGRRPSRGLAGASG 662
L + +RA D EA ++ + E A L++A + +R A
Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
+++ +A + L E M+ E + + Q+E + +LQ + +E+ AQ
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED----KEQMAQ 2333
Query: 723 VLGHVEQLKVRVKELEQQ--LQESA-------REAEMERALLQGEREAERALLQKEQKAV 773
L Q R E E+Q L+ SA R AEM RA + E +A+R +K
Sbjct: 2334 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----RKQA 2388
Query: 774 DQLQEKLVALETGIQK---------------------------ERDKEAEALETETKLFE 806
+++ EKL E Q+ E ++E E L+ E KL +
Sbjct: 2389 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2448
Query: 807 --DLEFQQLERESRVEEERELAGQGLLRSKAELL---RSIAKRKERLAILDSQAGQIRAQ 861
E Q +++E ++E + L Q L K LL R I + K +L Q+
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERFIEQEKAKLE-------QLFQD 2500
Query: 862 AVQESERLARDKNASLQLLQKEKEKLTV----LERRYHSLTGG 900
V ++++L ++ Q +++E+++L RR H G
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543
Score = 53.9 bits (128), Expect = 1e-06
Identities = 80/317 (25%), Positives = 133/317 (41%), Gaps = 57/317 (17%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEA 633
ER + + SD+E +RQ+ L E + R RQ E IL L A + +A G
Sbjct: 1871 ERLAQLRKASDSE--------LERQKGLVEDTL-RQRRQVEEEILALKASFEKAAAGKAE 1921
Query: 634 GELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSS 693
EL GR S + E A QR + E
Sbjct: 1922 LELE-----------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEE------------- 1957
Query: 694 TESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERA 753
E ++E E+ L E A + +A L VE+LK +V+E ++L+E A
Sbjct: 1958 -ERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEA-RRLRERA-------- 2006
Query: 754 LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQ-- 811
E+E+ R L ++ A +LQ + A +Q++ + + L+ E + + L +
Sbjct: 2007 ----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062
Query: 812 ------QLERESRVEEERELAGQGLLRSKAELLRSIAKRK-ERLAILDSQAGQIRAQAVQ 864
+ E+RV+ ERE A +AE L+ A+ + + A + A ++R +A Q
Sbjct: 2063 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122
Query: 865 ESERLARDKNASLQLLQ 881
E+ R A+ + A+L+ Q
Sbjct: 2123 EAARRAQAEQAALRQKQ 2139
Score = 49.7 bits (117), Expect = 2e-05
Identities = 100/481 (20%), Positives = 195/481 (40%), Gaps = 76/481 (15%)
Query: 718 EERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQ-KAVDQL 776
+E+ Q + + VR EQ QE A E+ER GE+ E K+ A+
Sbjct: 1208 QEQIQAMPLADSQAVR----EQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1260
Query: 777 QEKLVALETGIQK-----ERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
+ +LV + ++ ++ K E+ + + DL E + + + + L
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320
Query: 832 RSKAE---LLRSIAKRKERLAILDS------QAGQIRAQAVQESERLARDKNASLQ--LL 880
R + E + A+ +ERLA +++ Q + AQA ++ER A++ +Q ++
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 881 QKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGS 940
++E+ + +++ R + L++ +++ +A RS
Sbjct: 1381 RREEAAVDAQQQK-------RSIQEELQQLRQSSEAEIQAKARQAEAAERS--------R 1425
Query: 941 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQ----KGQQ 996
++ V L + + + G + L A ++ E +++ A ++ + Q
Sbjct: 1426 LRIEEEIRVVRLQLEATERQ----RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1481
Query: 997 VIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGE 1056
E QR+R AE++ + +A+ + A L L R + E
Sbjct: 1482 QDESQRKRQAEVELASRVKAEAEAAREKQRA-----------------LQALEELRLQAE 1524
Query: 1057 EGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKN 1116
E E +E + ++ ++ T SA + AS + K ++E+ L+E H
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQLERSLQEEHVAVA 1582
Query: 1117 RLMESREREMELRRQALEEERRRREQVER-----RLQSESARRQQLVEKEVKMREKQFSQ 1171
+L E ER R Q E R RE+ ER +L++ A R +L +EV ++K +Q
Sbjct: 1583 QLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV-AQQKSLAQ 1637
Query: 1172 A 1172
A
Sbjct: 1638 A 1638
Score = 35.8 bits (81), Expect = 0.28
Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVE 1159
++EE E++ ++ AE+ + E +E +RQ E + + Q ER E+ QQ ++
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER----EAKELQQRMQ 1376
Query: 1160 KEVKMREKQFSQARPLTR 1177
+EV RE+ A+ R
Sbjct: 1377 EEVVRREEAAVDAQQQKR 1394
Score = 32.7 bits (73), Expect = 2.4
Identities = 72/333 (21%), Positives = 131/333 (39%), Gaps = 50/333 (15%)
Query: 568 RVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRA 627
R + + K ++ + + + ++ + +E + E E E+ + Q+ +L L +E
Sbjct: 2397 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-- 2454
Query: 628 DGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENL 687
+ + + + T AL + L R E+ ++L++ E + + L
Sbjct: 2455 ----QTVQQEQLLQETQALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQD-EVAKAQQL 2508
Query: 688 KEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESARE 747
+EE QQ + + Q V ++EE R + H + VR K+ E Q E R
Sbjct: 2509 REE-------QQRQQQQMEQERQRLVASMEEARRR--QHEAEEGVRRKQEELQQLEQQRR 2559
Query: 748 AEMERALLQGEREAER-ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFE 806
+ E + +R E+ LL+++ +A E++ A + K +AL+
Sbjct: 2560 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA---- 2615
Query: 807 DLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQES 866
E E E + GL R + A+R + IL ++ Q AQ
Sbjct: 2616 ------------AEAEPEHSFDGLRRKVS------AQRLQEAGILSAEELQRLAQGHTTV 2657
Query: 867 ERLAR--DKNASLQ--------LLQKEKEKLTV 889
+ LAR D LQ LL+ EKL+V
Sbjct: 2658 DELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2690
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/628 (22%), Positives = 252/628 (40%), Gaps = 82/628 (13%)
Query: 600 RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAG 659
R R +E E +RQ E L + E+ + A A A R R L
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV-ELASRVKAEAEAAREKQRAL-- 1521
Query: 660 ASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEE 719
++ EE + + + +++ E ++ + E+ Q+ E +LQ + + E+
Sbjct: 1522 ---QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE----AELQSKRASFAEK 1574
Query: 720 RAQVLGHVEQLKVRVKELEQQLQESARE-AEMERALLQGEREAERALLQKEQKAVDQLQE 778
AQ+ +++ V V +L ++ + A++ AE ERA + ERE ER L+ + +LQ
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634
Query: 779 KLVALETGI-QKERDKEAEALETETKLFEDLEFQQLER----ESRVEEERELA---GQGL 830
+ VA + + Q E +K+ E E E + E Q + + E +E++R+LA Q
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694
Query: 831 LRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVL 890
L ++ EL+R A+ + Q Q R +E RL R+ A+ Q Q+ + +L +
Sbjct: 1695 LAAEQELIRLRAETE--------QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1746
Query: 891 ERRYHSLTGGRPFPKTTS-TLKEVYRSKMDGEATSPLPRTRSGP-LPSSSGSSSSSSQLS 948
L + + S + E + +++ EA L + + + QL+
Sbjct: 1747 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1806
Query: 949 VATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE---QRRRL 1005
R + +L + T +I K + A ++ +++ E+ QRRRL
Sbjct: 1807 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1866
Query: 1006 AELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTL 1065
E + A+ + + L A+ ++ R + EE + L
Sbjct: 1867 EEQAAQHKADIEERLAQLRKASDSELE-------RQKGLVEDTLRQRRQVEE-----EIL 1914
Query: 1066 SLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE-EMEKMLKEAHAEKN-RLMESRE 1123
+L++S + GK E E+E ++AE R E E
Sbjct: 1915 ALKASFEKAAA----------------------GKAELELELGRIRSNAEDTLRSKEQAE 1952
Query: 1124 REMELRRQALEEERRRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQARPL-- 1175
E +RQ EE RRR + E R+Q E+AR+++ +EV+ + + +AR L
Sbjct: 1953 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012
Query: 1176 ------TRYLPIRKEDFDLKTHIESSGH 1197
R L + +E + E H
Sbjct: 2013 RAEQESARQLQLAQEAAQKRLQAEEKAH 2040
Score = 70.5 bits (171), Expect = 1e-11
Identities = 132/612 (21%), Positives = 241/612 (39%), Gaps = 88/612 (14%)
Query: 591 EYHRRQRQE---RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALA 647
E +RQ QE RLR Q + +R+R + + A+ A E +A L
Sbjct: 1472 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQRALQALEELR 1528
Query: 648 LAGRRPSRGLAGASGRSSEEPGVA---TQRLWESMERSDEENLKEECSSTE-STQQEHED 703
L R L A + + VA QR E+ +S + E+ + E S Q+EH
Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1588
Query: 704 APSTKLQGEVLALEEERAQ-------------VLGHVEQLKVRVKELEQQLQESAREAEM 750
+ + E A ++ A+ L E L++R++ E Q+S +AE
Sbjct: 1589 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648
Query: 751 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF 810
E+ + EREA R KA +Q + E ++K+R + AE + +L + E
Sbjct: 1649 EKQKEEAEREARR-----RGKAEEQAVRQRELAEQELEKQR-QLAEG-TAQQRLAAEQEL 1701
Query: 811 QQLERES-RVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERL 869
+L E+ + E++R+L + L R + E + KR+E L+++ ++RA+
Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE----LEAELAKVRAEMEVLLASK 1757
Query: 870 ARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRT 929
AR + S +K K++L R+ L + + +E R + E + R
Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFREL--AEEAARLRALAEEAKRQRQLAEEDAARQRA 1815
Query: 930 RSGPLPSSSGSSSSSSQLSVATLGRSPSPKS----ALLTQNGTGSLPRNLAATLQDIETK 985
+ + + +A +G + K+ AL + R LA + E
Sbjct: 1816 EAERVLAE----------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA----EDEAF 1861
Query: 986 RQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL 1045
++ L+++ Q + RLA+L++ + +E + Q +
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------------------- 1902
Query: 1046 HHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE--- 1102
L R+ EE + ++ E + G + + D + S ++
Sbjct: 1903 --LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1960
Query: 1103 ---EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVE------RRLQSESAR 1153
E E+ +EA + + + E R+ ALEE R + +VE R + ESAR
Sbjct: 1961 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2020
Query: 1154 RQQLVEKEVKMR 1165
+ QL ++ + R
Sbjct: 2021 QLQLAQEAAQKR 2032
Score = 70.1 bits (170), Expect = 1e-11
Identities = 133/640 (20%), Positives = 256/640 (40%), Gaps = 103/640 (16%)
Query: 591 EYHRRQRQERLR-----EQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
E RR+ +ER++ E+E R + LE + L A+ A E E S + A
Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2025
Query: 646 LALAGRR-PSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDA 704
A +R + A A +E Q L +++++ ++ L + E+ ++ E+A
Sbjct: 2026 QEAAQKRLQAEEKAHAFAVQQKE-----QELQQTLQQ-EQSVLDQLRGEAEAARRAAEEA 2079
Query: 705 PSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAR-EAEMERALLQGEREAER 763
++Q E E AQ VE+ + + E+Q Q A+ +A E+ + E+EA R
Sbjct: 2080 EEARVQAE-----REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 764 ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEER 823
Q EQ A+ Q Q A + ++K + + L + ++ ++L +L+ E + ++
Sbjct: 2135 RA-QAEQAALRQKQ----AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-TDHQK 2188
Query: 824 ELAGQGLLRSKAELLRSIAKRKE------RLAILDSQAGQIRAQAVQESERLA-RDKNAS 876
L + L R KAE + +R + + + + +++A+ E+ L RDK+ +
Sbjct: 2189 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2248
Query: 877 LQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPS 936
+ LQ+E EK+ +E R + + + L + L
Sbjct: 2249 QRFLQEEAEKMK-------------------QVAEEAARLSVAAQEAARLRQLAEEDLAQ 2289
Query: 937 SSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETK--RQLALQQKG 994
+ + + + + K+ L + A LQ+ + + +QLA + +G
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2349
Query: 995 -QQVIEEQRRRLAE-------LKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL- 1045
Q+ +E +R+R E LK + A ++ Q A A F +H + L
Sbjct: 2350 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2409
Query: 1046 -------------------HHLPAGRERGEEGEHAYDTLSLES------SDSMETSISTG 1080
H RE E E + L E+ S+ M+T
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----- 2464
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAH---AEKNRLMESREREMELRRQALEEER 1137
+ L + E + +L+ EK +L + + E+ +Q EE++
Sbjct: 2465 ---VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2521
Query: 1138 RRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQ 1171
R+++Q+E+ Q E+ RRQ E+ V+ ++++ Q
Sbjct: 2522 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2561
Score = 69.3 bits (168), Expect = 2e-11
Identities = 144/623 (23%), Positives = 242/623 (38%), Gaps = 84/623 (13%)
Query: 584 DNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEAT 643
+ E+ L E R + +ERL E E LE+QR L ++A EA EL +
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAA-LEKQRQ---LAEAHAQAKAQAEREAKEL----QQR 1382
Query: 644 AALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHED 703
+ R + A RS +E Q+L +S E + ++ ++ S + E+
Sbjct: 1383 MQEEVVRREEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439
Query: 704 APSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGERE--- 760
+LQ E A E +R G ++ L+ R +E E Q +++ EAE R +Q E +
Sbjct: 1440 IRVVRLQLE--ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1497
Query: 761 -----------AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE-------ALETET 802
AE +++Q+A+ L+E + E ++ R E E ALET
Sbjct: 1498 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1557
Query: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQA 862
+ E E Q +R S E+ +L + L+ + + + + ER A ++A + R +A
Sbjct: 1558 RSAE-AELQS-KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1613
Query: 863 VQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEA 922
+E ER N +L+L + +E V +++ SL + +E R G+A
Sbjct: 1614 ERELERWQLKANEALRLRLQAEE---VAQQK--SLAQAEAEKQKEEAEREARRR---GKA 1665
Query: 923 TSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL---TQNGTGSLPRNLAATL 979
R R + QL+ T + + + L+ + G R L
Sbjct: 1666 EEQAVRQRE----LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1721
Query: 980 QDIETKRQLALQQKGQQVIEEQRRRLAE----LKQKAAAEAQCQWDALHGAAPFPAGPSG 1035
+ A QK Q++ E + AE L KA AE + + + A
Sbjct: 1722 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1781
Query: 1036 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG 1095
F RE EE L+ E+ + + + + +
Sbjct: 1782 F---------------RELAEEAAR-LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825
Query: 1096 LDMGKI----EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRL---- 1147
+G+ E E LKE AE RL E E RR+ E+ + + +E RL
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885
Query: 1148 ---QSESARRQQLVEKEVKMREK 1167
SE R++ LVE ++ R +
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQ 1908
Score = 66.2 bits (160), Expect = 2e-10
Identities = 159/722 (22%), Positives = 273/722 (37%), Gaps = 135/722 (18%)
Query: 595 RQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPS 654
R++Q L+ E RL+ + E L AE RA A E + +A L +R S
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQ-AEVERARQVQVALET---AQRSAEAELQSKRAS 1570
Query: 655 RGLAGAS-GRSSEEPGVATQRLWESMER-----SDEENLKEECS-STESTQQEHEDAPST 707
A RS +E VA +L E ER ++ E +EE E Q + +A
Sbjct: 1571 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1630
Query: 708 KLQGEVLALEEERAQV---------------LGHVEQLKVRVKELEQQLQESARE----- 747
+LQ E +A ++ AQ G E+ VR +EL +Q E R+
Sbjct: 1631 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690
Query: 748 ------AEMERALL-----QGER-----EAERALLQKEQKAVDQLQEKLVALETGIQKER 791
AE E L QGE+ E E A LQ+E A Q +++L A ++ E
Sbjct: 1691 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1750
Query: 792 D------------------KEAEALETETKLFEDLEFQQLERESRVEE---ERELAGQGL 830
+ K + LE E F +L + + EE +R+LA +
Sbjct: 1751 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1810
Query: 831 LRSKAELLRSIA------------KRKERLAILDSQAGQIRAQAVQESERLARDK----- 873
R +AE R +A K + +A+ + +A R + + E E R +
Sbjct: 1811 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870
Query: 874 -----NASLQLLQKEKEKLTVLERRY----HSLTGGRPFPKTTSTLKEVYRSKMDGEATS 924
+ +L Q K + LER+ +L R + LK + G+A
Sbjct: 1871 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1930
Query: 925 PLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIET 984
L R + S ++L A R + + + + ++LAA ++
Sbjct: 1931 ELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAE-EEAAR 1988
Query: 985 KRQLALQQ--KGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLM-- 1040
+R+ AL++ + + +EE RR +Q++A + Q +A F
Sbjct: 1989 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2048
Query: 1041 ---------HHSILHHL----PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP 1087
S+L L A R EE E A E++ S + S
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR-QVEEAERLKQSA 2107
Query: 1088 DNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESR----------EREMELRRQALEEER 1137
+ + A E K+ KEA E R ++ + EME ++ E+
Sbjct: 2108 EEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164
Query: 1138 RRREQVERRLQS------ESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTH 1191
R++ QVE+ L + E+ ++ L+++E++ + + ++A + + +E F ++
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA--ARQRSQVEEELFSVRVQ 2222
Query: 1192 IE 1193
+E
Sbjct: 2223 ME 2224
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/403 (22%), Positives = 163/403 (40%), Gaps = 73/403 (18%)
Query: 554 QSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQR 613
Q V+++L++ L++ T +KN + E RQR + E R++ +
Sbjct: 2166 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225
Query: 614 LETILNLCAEYSRA------DGGP-----EAGELPSIGEATAALALAGRRPSRGLAGASG 662
L + +RA D EA ++ + E A L++A + +R A
Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
+++ +A + L E M+ E + + Q+E + +LQ + +E+ AQ
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED----KEQMAQ 2341
Query: 723 VLGHVEQLKVRVKELEQQ--LQESA-------REAEMERALLQGEREAERALLQKEQKAV 773
L Q R E E+Q L+ SA R AEM RA + E +A+R +K
Sbjct: 2342 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----RKQA 2396
Query: 774 DQLQEKLVALETGIQK---------------------------ERDKEAEALETETKLFE 806
+++ EKL E Q+ E ++E E L+ E KL +
Sbjct: 2397 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2456
Query: 807 --DLEFQQLERESRVEEERELAGQGLLRSKAELL---RSIAKRKERLAILDSQAGQIRAQ 861
E Q +++E ++E + L Q L K LL R I + K +L Q+
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERFIEQEKAKLE-------QLFQD 2508
Query: 862 AVQESERLARDKNASLQLLQKEKEKLTV----LERRYHSLTGG 900
V ++++L ++ Q +++E+++L RR H G
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2551
Score = 53.9 bits (128), Expect = 1e-06
Identities = 80/317 (25%), Positives = 133/317 (41%), Gaps = 57/317 (17%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEA 633
ER + + SD+E +RQ+ L E + R RQ E IL L A + +A G
Sbjct: 1879 ERLAQLRKASDSE--------LERQKGLVEDTL-RQRRQVEEEILALKASFEKAAAGKAE 1929
Query: 634 GELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSS 693
EL GR S + E A QR + E
Sbjct: 1930 LELE-----------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEE------------- 1965
Query: 694 TESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERA 753
E ++E E+ L E A + +A L VE+LK +V+E ++L+E A
Sbjct: 1966 -ERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEA-RRLRERA-------- 2014
Query: 754 LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQ-- 811
E+E+ R L ++ A +LQ + A +Q++ + + L+ E + + L +
Sbjct: 2015 ----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2070
Query: 812 ------QLERESRVEEERELAGQGLLRSKAELLRSIAKRK-ERLAILDSQAGQIRAQAVQ 864
+ E+RV+ ERE A +AE L+ A+ + + A + A ++R +A Q
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130
Query: 865 ESERLARDKNASLQLLQ 881
E+ R A+ + A+L+ Q
Sbjct: 2131 EAARRAQAEQAALRQKQ 2147
Score = 49.7 bits (117), Expect = 2e-05
Identities = 100/481 (20%), Positives = 195/481 (40%), Gaps = 76/481 (15%)
Query: 718 EERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQ-KAVDQL 776
+E+ Q + + VR EQ QE A E+ER GE+ E K+ A+
Sbjct: 1216 QEQIQAMPLADSQAVR----EQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1268
Query: 777 QEKLVALETGIQK-----ERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
+ +LV + ++ ++ K E+ + + DL E + + + + L
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1328
Query: 832 RSKAE---LLRSIAKRKERLAILDS------QAGQIRAQAVQESERLARDKNASLQ--LL 880
R + E + A+ +ERLA +++ Q + AQA ++ER A++ +Q ++
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 881 QKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGS 940
++E+ + +++ R + L++ +++ +A RS
Sbjct: 1389 RREEAAVDAQQQK-------RSIQEELQQLRQSSEAEIQAKARQAEAAERS--------R 1433
Query: 941 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQ----KGQQ 996
++ V L + + + G + L A ++ E +++ A ++ + Q
Sbjct: 1434 LRIEEEIRVVRLQLEATERQ----RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1489
Query: 997 VIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGE 1056
E QR+R AE++ + +A+ + A L L R + E
Sbjct: 1490 QDESQRKRQAEVELASRVKAEAEAAREKQRA-----------------LQALEELRLQAE 1532
Query: 1057 EGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKN 1116
E E +E + ++ ++ T SA + AS + K ++E+ L+E H
Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQLERSLQEEHVAVA 1590
Query: 1117 RLMESREREMELRRQALEEERRRREQVER-----RLQSESARRQQLVEKEVKMREKQFSQ 1171
+L E ER R Q E R RE+ ER +L++ A R +L +EV ++K +Q
Sbjct: 1591 QLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV-AQQKSLAQ 1645
Query: 1172 A 1172
A
Sbjct: 1646 A 1646
Score = 35.8 bits (81), Expect = 0.28
Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVE 1159
++EE E++ ++ AE+ + E +E +RQ E + + Q ER E+ QQ ++
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER----EAKELQQRMQ 1384
Query: 1160 KEVKMREKQFSQARPLTR 1177
+EV RE+ A+ R
Sbjct: 1385 EEVVRREEAAVDAQQQKR 1402
Score = 32.7 bits (73), Expect = 2.4
Identities = 72/333 (21%), Positives = 131/333 (39%), Gaps = 50/333 (15%)
Query: 568 RVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRA 627
R + + K ++ + + + ++ + +E + E E E+ + Q+ +L L +E
Sbjct: 2405 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-- 2462
Query: 628 DGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENL 687
+ + + + T AL + L R E+ ++L++ E + + L
Sbjct: 2463 ----QTVQQEQLLQETQALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQD-EVAKAQQL 2516
Query: 688 KEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESARE 747
+EE QQ + + Q V ++EE R + H + VR K+ E Q E R
Sbjct: 2517 REE-------QQRQQQQMEQERQRLVASMEEARRR--QHEAEEGVRRKQEELQQLEQQRR 2567
Query: 748 AEMERALLQGEREAER-ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFE 806
+ E + +R E+ LL+++ +A E++ A + K +AL+
Sbjct: 2568 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA---- 2623
Query: 807 DLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQES 866
E E E + GL R + A+R + IL ++ Q AQ
Sbjct: 2624 ------------AEAEPEHSFDGLRRKVS------AQRLQEAGILSAEELQRLAQGHTTV 2665
Query: 867 ERLAR--DKNASLQ--------LLQKEKEKLTV 889
+ LAR D LQ LL+ EKL+V
Sbjct: 2666 DELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2698
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/628 (22%), Positives = 252/628 (40%), Gaps = 82/628 (13%)
Query: 600 RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAG 659
R R +E E +RQ E L + E+ + A A A R R L
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV-ELASRVKAEAEAAREKQRAL-- 1562
Query: 660 ASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEE 719
++ EE + + + +++ E ++ + E+ Q+ E +LQ + + E+
Sbjct: 1563 ---QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE----AELQSKRASFAEK 1615
Query: 720 RAQVLGHVEQLKVRVKELEQQLQESARE-AEMERALLQGEREAERALLQKEQKAVDQLQE 778
AQ+ +++ V V +L ++ + A++ AE ERA + ERE ER L+ + +LQ
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675
Query: 779 KLVALETGI-QKERDKEAEALETETKLFEDLEFQQLER----ESRVEEERELA---GQGL 830
+ VA + + Q E +K+ E E E + E Q + + E +E++R+LA Q
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 831 LRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVL 890
L ++ EL+R A+ + Q Q R +E RL R+ A+ Q Q+ + +L +
Sbjct: 1736 LAAEQELIRLRAETE--------QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1787
Query: 891 ERRYHSLTGGRPFPKTTS-TLKEVYRSKMDGEATSPLPRTRSGP-LPSSSGSSSSSSQLS 948
L + + S + E + +++ EA L + + + QL+
Sbjct: 1788 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1847
Query: 949 VATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEE---QRRRL 1005
R + +L + T +I K + A ++ +++ E+ QRRRL
Sbjct: 1848 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1907
Query: 1006 AELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTL 1065
E + A+ + + L A+ ++ R + EE + L
Sbjct: 1908 EEQAAQHKADIEERLAQLRKASDSELE-------RQKGLVEDTLRQRRQVEE-----EIL 1955
Query: 1066 SLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE-EMEKMLKEAHAEKN-RLMESRE 1123
+L++S + GK E E+E ++AE R E E
Sbjct: 1956 ALKASFEKAAA----------------------GKAELELELGRIRSNAEDTLRSKEQAE 1993
Query: 1124 REMELRRQALEEERRRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQARPL-- 1175
E +RQ EE RRR + E R+Q E+AR+++ +EV+ + + +AR L
Sbjct: 1994 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053
Query: 1176 ------TRYLPIRKEDFDLKTHIESSGH 1197
R L + +E + E H
Sbjct: 2054 RAEQESARQLQLAQEAAQKRLQAEEKAH 2081
Score = 70.5 bits (171), Expect = 1e-11
Identities = 132/612 (21%), Positives = 241/612 (39%), Gaps = 88/612 (14%)
Query: 591 EYHRRQRQE---RLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALA 647
E +RQ QE RLR Q + +R+R + + A+ A E +A L
Sbjct: 1513 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQRALQALEELR 1569
Query: 648 LAGRRPSRGLAGASGRSSEEPGVA---TQRLWESMERSDEENLKEECSSTE-STQQEHED 703
L R L A + + VA QR E+ +S + E+ + E S Q+EH
Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1629
Query: 704 APSTKLQGEVLALEEERAQ-------------VLGHVEQLKVRVKELEQQLQESAREAEM 750
+ + E A ++ A+ L E L++R++ E Q+S +AE
Sbjct: 1630 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689
Query: 751 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF 810
E+ + EREA R KA +Q + E ++K+R + AE + +L + E
Sbjct: 1690 EKQKEEAEREARR-----RGKAEEQAVRQRELAEQELEKQR-QLAEG-TAQQRLAAEQEL 1742
Query: 811 QQLERES-RVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERL 869
+L E+ + E++R+L + L R + E + KR+E L+++ ++RA+
Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE----LEAELAKVRAEMEVLLASK 1798
Query: 870 ARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRT 929
AR + S +K K++L R+ L + + +E R + E + R
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFREL--AEEAARLRALAEEAKRQRQLAEEDAARQRA 1856
Query: 930 RSGPLPSSSGSSSSSSQLSVATLGRSPSPKS----ALLTQNGTGSLPRNLAATLQDIETK 985
+ + + +A +G + K+ AL + R LA + E
Sbjct: 1857 EAERVLAE----------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA----EDEAF 1902
Query: 986 RQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL 1045
++ L+++ Q + RLA+L++ + +E + Q +
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------------------- 1943
Query: 1046 HHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIE--- 1102
L R+ EE + ++ E + G + + D + S ++
Sbjct: 1944 --LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2001
Query: 1103 ---EMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVE------RRLQSESAR 1153
E E+ +EA + + + E R+ ALEE R + +VE R + ESAR
Sbjct: 2002 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2061
Query: 1154 RQQLVEKEVKMR 1165
+ QL ++ + R
Sbjct: 2062 QLQLAQEAAQKR 2073
Score = 70.1 bits (170), Expect = 1e-11
Identities = 133/640 (20%), Positives = 256/640 (40%), Gaps = 103/640 (16%)
Query: 591 EYHRRQRQERLR-----EQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
E RR+ +ER++ E+E R + LE + L A+ A E E S + A
Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2066
Query: 646 LALAGRR-PSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDA 704
A +R + A A +E Q L +++++ ++ L + E+ ++ E+A
Sbjct: 2067 QEAAQKRLQAEEKAHAFAVQQKE-----QELQQTLQQ-EQSVLDQLRGEAEAARRAAEEA 2120
Query: 705 PSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAR-EAEMERALLQGEREAER 763
++Q E E AQ VE+ + + E+Q Q A+ +A E+ + E+EA R
Sbjct: 2121 EEARVQAE-----REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 764 ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEER 823
Q EQ A+ Q Q A + ++K + + L + ++ ++L +L+ E + ++
Sbjct: 2176 RA-QAEQAALRQKQ----AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-TDHQK 2229
Query: 824 ELAGQGLLRSKAELLRSIAKRKE------RLAILDSQAGQIRAQAVQESERLA-RDKNAS 876
L + L R KAE + +R + + + + +++A+ E+ L RDK+ +
Sbjct: 2230 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2289
Query: 877 LQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPS 936
+ LQ+E EK+ +E R + + + L + L
Sbjct: 2290 QRFLQEEAEKMK-------------------QVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330
Query: 937 SSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETK--RQLALQQKG 994
+ + + + + K+ L + A LQ+ + + +QLA + +G
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390
Query: 995 -QQVIEEQRRRLAE-------LKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL- 1045
Q+ +E +R+R E LK + A ++ Q A A F +H + L
Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2450
Query: 1046 -------------------HHLPAGRERGEEGEHAYDTLSLES------SDSMETSISTG 1080
H RE E E + L E+ S+ M+T
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQT----- 2505
Query: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAH---AEKNRLMESREREMELRRQALEEER 1137
+ L + E + +L+ EK +L + + E+ +Q EE++
Sbjct: 2506 ---VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2562
Query: 1138 RRREQVERRLQ------SESARRQQLVEKEVKMREKQFSQ 1171
R+++Q+E+ Q E+ RRQ E+ V+ ++++ Q
Sbjct: 2563 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2602
Score = 69.3 bits (168), Expect = 2e-11
Identities = 144/623 (23%), Positives = 242/623 (38%), Gaps = 84/623 (13%)
Query: 584 DNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEAT 643
+ E+ L E R + +ERL E E LE+QR L ++A EA EL +
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAA-LEKQRQ---LAEAHAQAKAQAEREAKEL----QQR 1423
Query: 644 AALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHED 703
+ R + A RS +E Q+L +S E + ++ ++ S + E+
Sbjct: 1424 MQEEVVRREEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480
Query: 704 APSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGERE--- 760
+LQ E A E +R G ++ L+ R +E E Q +++ EAE R +Q E +
Sbjct: 1481 IRVVRLQLE--ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1538
Query: 761 -----------AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE-------ALETET 802
AE +++Q+A+ L+E + E ++ R E E ALET
Sbjct: 1539 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1598
Query: 803 KLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQA 862
+ E E Q +R S E+ +L + L+ + + + + ER A ++A + R +A
Sbjct: 1599 RSAE-AELQS-KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1654
Query: 863 VQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEA 922
+E ER N +L+L + +E V +++ SL + +E R G+A
Sbjct: 1655 ERELERWQLKANEALRLRLQAEE---VAQQK--SLAQAEAEKQKEEAEREARRR---GKA 1706
Query: 923 TSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL---TQNGTGSLPRNLAATL 979
R R + QL+ T + + + L+ + G R L
Sbjct: 1707 EEQAVRQRE----LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762
Query: 980 QDIETKRQLALQQKGQQVIEEQRRRLAE----LKQKAAAEAQCQWDALHGAAPFPAGPSG 1035
+ A QK Q++ E + AE L KA AE + + + A
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1822
Query: 1036 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG 1095
F RE EE L+ E+ + + + + +
Sbjct: 1823 F---------------RELAEEAAR-LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866
Query: 1096 LDMGKI----EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRL---- 1147
+G+ E E LKE AE RL E E RR+ E+ + + +E RL
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926
Query: 1148 ---QSESARRQQLVEKEVKMREK 1167
SE R++ LVE ++ R +
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQ 1949
Score = 66.2 bits (160), Expect = 2e-10
Identities = 159/722 (22%), Positives = 273/722 (37%), Gaps = 135/722 (18%)
Query: 595 RQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPS 654
R++Q L+ E RL+ + E L AE RA A E + +A L +R S
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQ-AEVERARQVQVALET---AQRSAEAELQSKRAS 1611
Query: 655 RGLAGAS-GRSSEEPGVATQRLWESMER-----SDEENLKEECS-STESTQQEHEDAPST 707
A RS +E VA +L E ER ++ E +EE E Q + +A
Sbjct: 1612 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1671
Query: 708 KLQGEVLALEEERAQV---------------LGHVEQLKVRVKELEQQLQESARE----- 747
+LQ E +A ++ AQ G E+ VR +EL +Q E R+
Sbjct: 1672 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731
Query: 748 ------AEMERALL-----QGER-----EAERALLQKEQKAVDQLQEKLVALETGIQKER 791
AE E L QGE+ E E A LQ+E A Q +++L A ++ E
Sbjct: 1732 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1791
Query: 792 D------------------KEAEALETETKLFEDLEFQQLERESRVEE---ERELAGQGL 830
+ K + LE E F +L + + EE +R+LA +
Sbjct: 1792 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1851
Query: 831 LRSKAELLRSIA------------KRKERLAILDSQAGQIRAQAVQESERLARDK----- 873
R +AE R +A K + +A+ + +A R + + E E R +
Sbjct: 1852 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911
Query: 874 -----NASLQLLQKEKEKLTVLERRY----HSLTGGRPFPKTTSTLKEVYRSKMDGEATS 924
+ +L Q K + LER+ +L R + LK + G+A
Sbjct: 1912 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1971
Query: 925 PLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIET 984
L R + S ++L A R + + + + ++LAA ++
Sbjct: 1972 ELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAE-EEAAR 2029
Query: 985 KRQLALQQ--KGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLM-- 1040
+R+ AL++ + + +EE RR +Q++A + Q +A F
Sbjct: 2030 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089
Query: 1041 ---------HHSILHHL----PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP 1087
S+L L A R EE E A E++ S + S
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR-QVEEAERLKQSA 2148
Query: 1088 DNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESR----------EREMELRRQALEEER 1137
+ + A E K+ KEA E R ++ + EME ++ E+
Sbjct: 2149 EEQAQARAQAQAAAE---KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205
Query: 1138 RRREQVERRLQS------ESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTH 1191
R++ QVE+ L + E+ ++ L+++E++ + + ++A + + +E F ++
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA--ARQRSQVEEELFSVRVQ 2263
Query: 1192 IE 1193
+E
Sbjct: 2264 ME 2265
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/403 (22%), Positives = 163/403 (40%), Gaps = 73/403 (18%)
Query: 554 QSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQR 613
Q V+++L++ L++ T +KN + E RQR + E R++ +
Sbjct: 2207 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266
Query: 614 LETILNLCAEYSRA------DGGP-----EAGELPSIGEATAALALAGRRPSRGLAGASG 662
L + +RA D EA ++ + E A L++A + +R A
Sbjct: 2267 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2326
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
+++ +A + L E M+ E + + Q+E + +LQ + +E+ AQ
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED----KEQMAQ 2382
Query: 723 VLGHVEQLKVRVKELEQQ--LQESA-------REAEMERALLQGEREAERALLQKEQKAV 773
L Q R E E+Q L+ SA R AEM RA + E +A+R +K
Sbjct: 2383 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----RKQA 2437
Query: 774 DQLQEKLVALETGIQK---------------------------ERDKEAEALETETKLFE 806
+++ EKL E Q+ E ++E E L+ E KL +
Sbjct: 2438 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2497
Query: 807 --DLEFQQLERESRVEEERELAGQGLLRSKAELL---RSIAKRKERLAILDSQAGQIRAQ 861
E Q +++E ++E + L Q L K LL R I + K +L Q+
Sbjct: 2498 LKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERFIEQEKAKLE-------QLFQD 2549
Query: 862 AVQESERLARDKNASLQLLQKEKEKLTV----LERRYHSLTGG 900
V ++++L ++ Q +++E+++L RR H G
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2592
Score = 53.9 bits (128), Expect = 1e-06
Identities = 80/317 (25%), Positives = 133/317 (41%), Gaps = 57/317 (17%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEA 633
ER + + SD+E +RQ+ L E + R RQ E IL L A + +A G
Sbjct: 1920 ERLAQLRKASDSE--------LERQKGLVEDTL-RQRRQVEEEILALKASFEKAAAGKAE 1970
Query: 634 GELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSS 693
EL GR S + E A QR + E
Sbjct: 1971 LELE-----------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEE------------- 2006
Query: 694 TESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERA 753
E ++E E+ L E A + +A L VE+LK +V+E ++L+E A
Sbjct: 2007 -ERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEA-RRLRERA-------- 2055
Query: 754 LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQ-- 811
E+E+ R L ++ A +LQ + A +Q++ + + L+ E + + L +
Sbjct: 2056 ----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111
Query: 812 ------QLERESRVEEERELAGQGLLRSKAELLRSIAKRK-ERLAILDSQAGQIRAQAVQ 864
+ E+RV+ ERE A +AE L+ A+ + + A + A ++R +A Q
Sbjct: 2112 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171
Query: 865 ESERLARDKNASLQLLQ 881
E+ R A+ + A+L+ Q
Sbjct: 2172 EAARRAQAEQAALRQKQ 2188
Score = 49.7 bits (117), Expect = 2e-05
Identities = 100/481 (20%), Positives = 195/481 (40%), Gaps = 76/481 (15%)
Query: 718 EERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQ-KAVDQL 776
+E+ Q + + VR EQ QE A E+ER GE+ E K+ A+
Sbjct: 1257 QEQIQAMPLADSQAVR----EQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1309
Query: 777 QEKLVALETGIQK-----ERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
+ +LV + ++ ++ K E+ + + DL E + + + + L
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369
Query: 832 RSKAE---LLRSIAKRKERLAILDS------QAGQIRAQAVQESERLARDKNASLQ--LL 880
R + E + A+ +ERLA +++ Q + AQA ++ER A++ +Q ++
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 881 QKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGS 940
++E+ + +++ R + L++ +++ +A RS
Sbjct: 1430 RREEAAVDAQQQK-------RSIQEELQQLRQSSEAEIQAKARQAEAAERS--------R 1474
Query: 941 SSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQ----KGQQ 996
++ V L + + + G + L A ++ E +++ A ++ + Q
Sbjct: 1475 LRIEEEIRVVRLQLEATERQ----RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1530
Query: 997 VIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGE 1056
E QR+R AE++ + +A+ + A L L R + E
Sbjct: 1531 QDESQRKRQAEVELASRVKAEAEAAREKQRA-----------------LQALEELRLQAE 1573
Query: 1057 EGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKN 1116
E E +E + ++ ++ T SA + AS + K ++E+ L+E H
Sbjct: 1574 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQLERSLQEEHVAVA 1631
Query: 1117 RLMESREREMELRRQALEEERRRREQVER-----RLQSESARRQQLVEKEVKMREKQFSQ 1171
+L E ER R Q E R RE+ ER +L++ A R +L +EV ++K +Q
Sbjct: 1632 QLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV-AQQKSLAQ 1686
Query: 1172 A 1172
A
Sbjct: 1687 A 1687
Score = 35.8 bits (81), Expect = 0.28
Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVE 1159
++EE E++ ++ AE+ + E +E +RQ E + + Q ER E+ QQ ++
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER----EAKELQQRMQ 1425
Query: 1160 KEVKMREKQFSQARPLTR 1177
+EV RE+ A+ R
Sbjct: 1426 EEVVRREEAAVDAQQQKR 1443
Score = 32.7 bits (73), Expect = 2.4
Identities = 72/333 (21%), Positives = 131/333 (39%), Gaps = 50/333 (15%)
Query: 568 RVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRA 627
R + + K ++ + + + ++ + +E + E E E+ + Q+ +L L +E
Sbjct: 2446 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-- 2503
Query: 628 DGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENL 687
+ + + + T AL + L R E+ ++L++ E + + L
Sbjct: 2504 ----QTVQQEQLLQETQALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQD-EVAKAQQL 2557
Query: 688 KEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESARE 747
+EE QQ + + Q V ++EE R + H + VR K+ E Q E R
Sbjct: 2558 REE-------QQRQQQQMEQERQRLVASMEEARRR--QHEAEEGVRRKQEELQQLEQQRR 2608
Query: 748 AEMERALLQGEREAER-ALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFE 806
+ E + +R E+ LL+++ +A E++ A + K +AL+
Sbjct: 2609 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA---- 2664
Query: 807 DLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQES 866
E E E + GL R + A+R + IL ++ Q AQ
Sbjct: 2665 ------------AEAEPEHSFDGLRRKVS------AQRLQEAGILSAEELQRLAQGHTTV 2706
Query: 867 ERLAR--DKNASLQ--------LLQKEKEKLTV 889
+ LAR D LQ LL+ EKL+V
Sbjct: 2707 DELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2739
>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
Length = 1970
Score = 75.9 bits (185), Expect = 2e-13
Identities = 109/420 (25%), Positives = 155/420 (36%), Gaps = 46/420 (10%)
Query: 145 IPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSL 204
IP+ G A P YSP E G +TPQ+ + P++ S+S S +
Sbjct: 1582 IPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTS-PSYSPTSPSYSPTSPNYSPTS 1640
Query: 205 VLEEPGAAGKKPAAT--SPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPA 262
P + P + SP SP + PTSP SY TSP++SP +SP+
Sbjct: 1641 PSYSPTSPSYSPTSPSYSPTSPSYS--------PTSPSYSPTSPSYSPTSPSYSP-TSPS 1691
Query: 263 SSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARS-ESPRLSRKGGHER 321
S + S+SP+ P+ P P +S + P S S + S SP S +
Sbjct: 1692 YSPTSPSYSPTSPSYSPTSPSYSP--TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYS 1749
Query: 322 PPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTS---I 378
P SP SP+ + + + T SP P + + Y + PTS
Sbjct: 1750 PTSP---NYTPTSPSYSPTSPSYSPT-SPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYS 1805
Query: 379 PGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTL 438
P SP++ P P PS P S TSP ++S T
Sbjct: 1806 PSSPRYTPQSPT----------YTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTP 1855
Query: 439 QPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPR--PRRWA 496
P+ + + + P SP+ S PT T P SP+ P
Sbjct: 1856 TSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPT 1915
Query: 497 AHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSP 556
SP+ +S T T SP+ G + +P +S SP YSL SP SP
Sbjct: 1916 YSPTSPK-YSPT-----SPTYSPTSPKGSTYSPTSPGYS-PTSPTYSL-----TSPAISP 1963
Score = 62.4 bits (150), Expect = 3e-09
Identities = 85/297 (28%), Positives = 109/297 (36%), Gaps = 36/297 (12%)
Query: 209 PGAAGKKPAATSPLSPMANGGRYLLSP-PTSPGAMSVGSSYENT-----SPAFSPLS--- 259
PGAAG P+A S S + G SP P SPG+ S Y + SP++SP S
Sbjct: 1541 PGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAY 1600
Query: 260 SPASSGSCASHSPSGQEPGPSVPPLVPARS--SSYHLALQPPQSRPSGARS-ESPRLSRK 316
P S G SPS PS P P+ S S + P S S + S SP S
Sbjct: 1601 EPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPT 1660
Query: 317 GGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPT 376
P SP SP+ + + + T SP P + + Y + PT
Sbjct: 1661 SPSYSPTSPSYS---PTSPSYSPTSPSYSPT-SPSYSPTSPSYSPTSPSYSPTSPSYSPT 1716
Query: 377 S---IPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGL 433
S P SP + P P + T P+ P S TSPS ++S
Sbjct: 1717 SPSYSPTSPSYSPTSP---SYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYS--- 1770
Query: 434 ATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESP 490
T P SP P SPS S + S PT + P R +SP
Sbjct: 1771 PTSPNYTPTSPNYS-----------PTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSP 1816
Score = 52.8 bits (125), Expect = 2e-06
Identities = 90/349 (25%), Positives = 125/349 (35%), Gaps = 37/349 (10%)
Query: 213 GKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSP 272
G P+ +SP +P + SVGS + FSP ++ +SG +SP
Sbjct: 1504 GSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPGYSP 1563
Query: 273 SGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGLLT 332
+ P P P P SS Y PS + SP S P SPG G
Sbjct: 1564 A-WSPTPGSPG-SPGPSSPY---------IPSPGGAMSPSYSPTSPAYEPRSPG--GYTP 1610
Query: 333 DSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTS---IPGSPKFQPPVP 389
SP+ + + + T SP P + + Y + PTS P SP + P P
Sbjct: 1611 QSPSYSPTSPSYSPT-SPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSP 1669
Query: 390 APRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRR 449
+ + PS P S TSPS ++S T P SP
Sbjct: 1670 SYSPTSPSYSPTSPS---YSPTSPSYSPTSPSYSPTSPSYS---PTSPSYSPTSPSYS-- 1721
Query: 450 GLDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTL 509
+ P SPS S + S PT P SP ++ + +S T
Sbjct: 1722 --PTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSP------SYSPTSPSYSPTS 1773
Query: 510 GARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGS--LTGASPCQSP 556
+ + SPT S +P S+S SP+YS S T SP +P
Sbjct: 1774 PNYTPTSPNYSPT-SPSYSPTSPSYS-PTSPSYSPSSPRYTPQSPTYTP 1820
Score = 32.0 bits (71), Expect = 4.0
Identities = 49/179 (27%), Positives = 66/179 (36%), Gaps = 38/179 (21%)
Query: 154 PPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVS-------------SIEKDLQEI 200
P YSP + S S + +TPQ+ T PS+ + S S S E
Sbjct: 1795 PSYSPT-SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEY 1853
Query: 201 MDSLVLEEPGAAGKKPAAT--SPLSPMANGGRYLLSP-------------PTSPGAMSVG 245
+ P + P + SP SP + SP PTSP
Sbjct: 1854 TPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTS 1913
Query: 246 SSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHL---ALQPPQS 301
+Y TSP +SP +SP S + SP G P+ P P S +Y L A+ P S
Sbjct: 1914 PTYSPTSPKYSP-TSPTYSPT----SPKGSTYSPTSPGYSPT-SPTYSLTSPAISPDDS 1966
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 75.9 bits (185), Expect = 2e-13
Identities = 84/327 (25%), Positives = 146/327 (44%), Gaps = 30/327 (9%)
Query: 573 RERKNSITEISDNEDDLLEYHRRQRQE----RLREQEMERLERQRLETILNLCAEYSRAD 628
+ER+ + E + + LE RQR++ R R++ ER ER+ E L C
Sbjct: 144 QERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK------ 197
Query: 629 GGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQ-----RLWESMERSD 683
G E E P + L RR R R ++ + R E++ R +
Sbjct: 198 -GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKE 256
Query: 684 EENLKEECSSTESTQQEHEDAPSTKLQGEVLALE----EERAQVLGHVEQLKVRVKELEQ 739
EE L+EE + QE E+ KL+ + L E E++ Q L +QL+ + +E +
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQ-LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 740 QLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALE 799
+ QE RE + ER Q ER ++ ++E++ QL+ + Q R++E E E
Sbjct: 316 EQQEERRE-QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 800 TETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIR 859
+ + QQL RE ++ E++L + LR + +L R R+E+ + Q+R
Sbjct: 375 QQLR-----REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL---RREQQLR 426
Query: 860 AQAVQESERLARDKNASLQLLQKEKEK 886
+ +E ++ Q L++E+E+
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEE 453
Score = 65.9 bits (159), Expect = 3e-10
Identities = 113/530 (21%), Positives = 205/530 (38%), Gaps = 50/530 (9%)
Query: 666 EEPGVATQRLWESMER--SDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ- 722
EEPG ++ + ER ++ E E+ E ++ D + + E EE RA+
Sbjct: 131 EEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE 190
Query: 723 -----VLGH-VEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQL 776
GH E+ + ++L E R+ E+ + ER+ +R ++E+K +
Sbjct: 191 EQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ-DRVFQEEEEKEWRKR 249
Query: 777 QEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAE 836
+ L E +Q+E + L+ E + LE Q+L RE + EE+++ Q L R +
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ---QRLRREQQL 306
Query: 837 LLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASL-QLLQKEKEKLTVLERRYH 895
+ +R+E+ Q + Q + ++L R++ Q L++E+E+ ERR
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE----ERREQ 362
Query: 896 SLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRS 955
L + + L+ + + + + R L L R
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422
Query: 956 PSPKSALLTQNGTGSLPR-NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAA 1014
+ + + L+ + +R+ L+++ + EQ RR +LK+
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE 482
Query: 1015 EAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSME 1074
E + +W L ER E+ E L E + E
Sbjct: 483 ERRERWLKLE--------------------------EEERREQQERREQQLRREQEERRE 516
Query: 1075 TSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLK---EAHAEKNRLMESREREMELRR- 1130
+ + S L + E E++LK E E+ R + +RE E RR
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD 576
Query: 1131 QALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLP 1180
Q L+ E RR+Q +R Q E Q+L +EV+ E++ + + L R P
Sbjct: 577 QLLKREEERRQQRLKREQEERL-EQRLKREEVERLEQEERREQRLKREEP 625
Score = 65.9 bits (159), Expect = 3e-10
Identities = 68/314 (21%), Positives = 135/314 (42%), Gaps = 12/314 (3%)
Query: 575 RKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAG 634
R+ + E+ + + RR+RQ+R+ ++E E+ R+R ET+L E + +
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR-ETVLRKEEEKLQEEEPQRQR 269
Query: 635 ELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSST 694
EL E L R R EE R + + R EE +E+
Sbjct: 270 ELQEEEEQLRKLERQELRRER--------QEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 695 ESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERAL 754
Q+ E + Q EE R Q L ++ + R ++L ++ +E RE ++ R
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 755 LQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERD--KEAEALETETKLFEDLEFQQ 812
Q RE + Q+ ++ +E+ + E +++E+ +E + + + + + +Q
Sbjct: 382 -QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 813 LERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARD 872
RE R++ E+E L R + +RK++L + + R ++E ER +
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Query: 873 KNASLQLLQKEKEK 886
+ QL ++++E+
Sbjct: 501 ERREQQLRREQEER 514
Score = 65.5 bits (158), Expect = 3e-10
Identities = 138/658 (20%), Positives = 243/658 (36%), Gaps = 77/658 (11%)
Query: 559 QRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETIL 618
QR LR ER+ E + ++ + R+ Q+ REQE R ++ R E
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 619 NLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWES 678
+ R + E E E RR + L E+ Q+L
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ-LRREQQLRREQQLRREQQLRRE 416
Query: 679 MERSDEENLKEECSSTESTQQEHEDAPSTKLQGEV------LALEEE--------RAQVL 724
+ E+ L+ E Q+ ++ +L+ E L EEE R Q L
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 725 GHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALE 784
++ + R + L+ + +E + E L+ E+E R K Q+ ++LQ++L + E
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS-E 535
Query: 785 TGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKR 844
+++E+++ E L K E+ +Q RE R++ E+E LL+ + E +R
Sbjct: 536 QQLRREQEERREQL---LKREEEKRLEQERREQRLKREQEERRDQLLKREEE------RR 586
Query: 845 KERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFP 904
++RL + + R + +E ERL +++ +L ++E E+ ERR L
Sbjct: 587 QQRLKREQEERLEQRLKR-EEVERLEQEERREQRLKREEPEE----ERRQQLLKSEEQEE 641
Query: 905 KTTSTLK---------EVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRS 955
+ L+ + R + + L R + Q R
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI 701
Query: 956 PS-----PKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQ 1010
P A Q+ S PR + E + + ++ Q EE+R + ++
Sbjct: 702 PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE 761
Query: 1011 KAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESS 1070
+ + QW A + S PPL RER L E
Sbjct: 762 EQRRDFTWQWQAEEKSERGRQRLSARPPLREQ---------RER---------QLRAEER 803
Query: 1071 DSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHA-----EKNRLMESRE-- 1123
E ++ +EE E++ + A E++ L E +E
Sbjct: 804 QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR 863
Query: 1124 REMELRRQ-----ALEEERRRREQ---VERRLQSESARRQQLVEKEVKMREKQFSQAR 1173
R E RR LEEER+RR + LQ + + QQL+++E + +++ + R
Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR 921
Score = 64.3 bits (155), Expect = 7e-10
Identities = 129/624 (20%), Positives = 233/624 (37%), Gaps = 83/624 (13%)
Query: 573 RERKNSITEISDNEDDLLEYHRRQRQERLREQEM-ERLERQRLETILNLCAEYSRADGGP 631
+ER+ + + E+ L + +R+ +E REQE+ E + Q E I + ++
Sbjct: 652 QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQ------ 705
Query: 632 EAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEEC 691
+L S +A + + R G + + ++ W+ ER+ + +EE
Sbjct: 706 --WQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Query: 692 -----------SSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQ 740
+E +Q P + Q E EER Q EQ + +E ++Q
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR----EQRFLPEEEEKEQ 819
Query: 741 LQESAREAEMERALLQGEREAERA-LLQKEQKAVDQLQEKLVALETGIQKERDKEAEALE 799
+ RE E E L+ E + +R Q+ Q+ D LQE + Q+ K LE
Sbjct: 820 RRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE 879
Query: 800 TETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIR 859
E K + + + ++ +E++L L + EL R +++ R Q Q R
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQL----LQEEEEELQREEREKRRR----QEQERQYR 931
Query: 860 A--QAVQESERLARDKNASLQLLQKEKE--KLTVLERRYHSLTGGRPFPKTTSTLKEVYR 915
Q QE E+L R++ + ++E++ K L+++ L G P + ++ YR
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 916 SK--MDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR 973
+ + E L R + R K L +
Sbjct: 992 EEEELQQEEEQLLREERE--------------KRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 974 NLAATLQDIET--KRQLALQQKGQQVIEEQR--RRLAELKQKAAAEAQCQWDALHGAAPF 1029
LQ+ E + + LQQ+ +Q++ E+R RR EL+++ E + Q +
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE-------- 1089
Query: 1030 PAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDN 1089
+L P R R E + L+ + +
Sbjct: 1090 -----------EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Query: 1090 MSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQS 1149
+ ++++ E+ L EK R E + E EEE+ RE+ E+R Q
Sbjct: 1139 QYR----EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQE 1194
Query: 1150 ESARRQQLVEKEVKMREKQFSQAR 1173
R +Q E+E R+K+ + R
Sbjct: 1195 ---RERQYREEEELQRQKRKQRYR 1215
Score = 63.5 bits (153), Expect = 1e-09
Identities = 131/640 (20%), Positives = 238/640 (37%), Gaps = 97/640 (15%)
Query: 574 ERKNSITEISDNEDDLLEYHRRQRQER-----LREQEMERLERQRLETILNLCAEYSRAD 628
ER+ + + + E+ + RR++QER RE+E ERLE++ E A+
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 629 GGPEAG-------------ELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRL 675
E +L S +A + + R G + + ++
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747
Query: 676 WESMERSDEENLKEEC-----------SSTESTQQEHEDAPSTKLQGEVLALEEERAQVL 724
W+ ER+ + +EE +E +Q P + Q E EER Q
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ-- 805
Query: 725 GHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAE-RALLQKEQKAVDQLQEKLVAL 783
EQ + +E ++Q + RE E E L+ E + + R Q+ Q+ D LQE
Sbjct: 806 --REQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR 863
Query: 784 ETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAK 843
+ Q+ K LE E K + + + ++ +E++L L + EL R +
Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL----LQEEEEELQREERE 919
Query: 844 RKERLAILDSQAGQIR--AQAVQESERLARDKNASLQLLQKEKE--KLTVLERRYHSLTG 899
++ R Q Q R Q QE E+L R++ + ++E++ K L+++ L G
Sbjct: 920 KRRR----QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 900 GRPFPKTTSTLKEVYR--SKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPS 957
P + ++ YR ++ E L R + R
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREER--------------EKRRRQEWERQYR 1021
Query: 958 PKSALLTQNGTGSLPRNLAATLQDIET--KRQLALQQKGQQVIEEQR--RRLAELKQKAA 1013
K L + LQ+ E + + LQQ+ +Q++ E+R RR EL+++
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 1014 AEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSM 1073
E + Q + +L P R R E + L+ +
Sbjct: 1082 KEEELQQE-------------------EEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 1074 ETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQAL 1133
+ ++ + E+ +++ + R + R EL RQ
Sbjct: 1123 -----------LLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR 1171
Query: 1134 EEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQAR 1173
EEE ++E+ E+ L+ E +R+Q E++ + E+ Q R
Sbjct: 1172 EEEELQQEE-EQLLREEQEKRRQERERQYREEEELQRQKR 1210
Score = 63.5 bits (153), Expect = 1e-09
Identities = 145/652 (22%), Positives = 244/652 (37%), Gaps = 96/652 (14%)
Query: 581 EISDNEDDLL-EYHRRQRQERLRE-QEMERLERQRLETILNLCAEYSRAD---------- 628
E+ E+ LL E ++RQER R+ +E E L+RQ+ + E R+D
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR--DEDQRSDLKWQWEPEKE 1232
Query: 629 ----------GGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWES 678
G E + + ++ L R+ + L G E +R W+
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQ----LRDRQSQQDLQHLLGEQQERDREQERRRWQQ 1288
Query: 679 MERS--DEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKE 736
+R +EE L+ E +Q+ K Q E L EER + E + + +E
Sbjct: 1289 RDRHFPEEEQLERE-------EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR-KFRE 1340
Query: 737 LEQQLQESA----REAEMERALLQGE---REAERALLQKEQKAVDQLQEKLVALETGIQK 789
EQ LQE R E +R + E +E R L++EQ+ Q +E+ E +
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400
Query: 790 ERDKEAEALETETKLFEDLEFQQLERESRV----EEERELAGQGLLRSKAELLRSIAKRK 845
+++E + + + F + E QQL R+ R EEE+++ Q R E + + + +
Sbjct: 1401 CQEREQQLRQDRDRKFREEE-QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459
Query: 846 ERLAILDSQAGQIRAQAVQESERLARDKN--ASLQLLQKEKEKLTVLERRYHSLTGGRPF 903
R + Q Q R + Q+ R RD+ Q L++++ E+ S R F
Sbjct: 1460 HRKFREEEQLLQEREE--QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517
Query: 904 PKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVAT------LGRSPS 957
+ L R + + L R G + + L R
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Query: 958 PKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQ 1017
+ L + R + +E ++QL Q+ QQ+ +E+ R+ E +Q +
Sbjct: 1578 DRKFRLEEQKV----RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 1018 CQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSI 1077
Q LH P L +ER ++ H D E E +
Sbjct: 1634 QQ---LHRQERDRKFLEEEPQLRR----------QEREQQLRHDRDRKFREE----EQLL 1676
Query: 1078 STGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALE--- 1134
G K E E+ L+ E+ L E E +LRRQ LE
Sbjct: 1677 QEGEEQQLRRQERDR-------KFREEEQQLRRQERERKFLQE----EQQLRRQELERKF 1725
Query: 1135 -EERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKED 1185
EE + R++ E+ R ++++E+E E++ Q R R R+E+
Sbjct: 1726 REEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE 1777
Score = 62.4 bits (150), Expect = 3e-09
Identities = 139/653 (21%), Positives = 238/653 (36%), Gaps = 60/653 (9%)
Query: 567 LRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSR 626
LR ER E E L +R RE+E ER E++R + L E R
Sbjct: 425 LRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER 484
Query: 627 ADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEEN 686
+ + E + R R EE + + E R ++E
Sbjct: 485 RERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE 544
Query: 687 LKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVR--VKELEQQLQES 744
+E+ E ++ ++ +L+ E EE R Q+L E+ + + +E E++L++
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQ---EERRDQLLKREEERRQQRLKREQEERLEQR 601
Query: 745 AREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALET-ETK 803
+ E+ER L Q ER +R L++E+ ++ Q+ L + E ++++ E E E +
Sbjct: 602 LKREEVER-LEQEERREQR--LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 804 LFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRK--ERLAILDSQAGQIRAQ 861
L + E ++LE+ + E E E Q L + E R K + + L+S+A +++
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 862 AV------------QESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTST 909
QE E R + + LQ ++E+ R+ R F
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA-----HRQQQEEEQRRDFTWQWQA 773
Query: 910 LKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTG 969
++ R + A PL R L + L K Q
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLP------EEEEKEQRRRQR--- 824
Query: 970 SLPRNLAATLQDIETKRQLALQQKGQQVIEEQ--------RRRLAELKQKAAAEAQCQWD 1021
R LQ +E + QL +++ QQ+ EE+ RRR E ++ Q + +
Sbjct: 825 ---REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881
Query: 1022 ALHGAAPFPAGPSGFPPLM--------HHSILHHLPAGRERGEEGEHAYDTLSLESSDSM 1073
A P+ L L + R +E E Y E
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR--EEEQLQQE 939
Query: 1074 ETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQAL 1133
E + D K+++ E+ L EK R E ++ E
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDK-KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 1134 EEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDF 1186
EEE+ RE+ E+R + E RQ + E++ E+Q + R L R+ +
Sbjct: 999 EEEQLLREEREKRRRQE-WERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Score = 58.2 bits (139), Expect = 5e-08
Identities = 122/617 (19%), Positives = 222/617 (35%), Gaps = 73/617 (11%)
Query: 568 RVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLE-RQRLETILNLCAEYSR 626
R+ R + E + D LL+ +RQ+RL+ ++ ERLE R + E + L E R
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616
Query: 627 ADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEEN 686
L P +S E+ Q+L + E+
Sbjct: 617 EQ------------------RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 687 LKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAR 746
LK E Q+ + + + E+ E+E+A+ E++K R+ + + QL ES
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQAR-----ERIKSRIPKWQWQL-ESEA 712
Query: 747 EAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFE 806
+A + R Q+ Q+ + +EK E+ +Q + ++ A + E +
Sbjct: 713 DARQSKVY-------SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765
Query: 807 DLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQES 866
D +Q E + L+ + LR + E +R++R Q + ++
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR-----EQRFLPEEEEKEQR 820
Query: 867 ERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPL 926
R R++ LQ L+ E+E+L E R L + + + D + L
Sbjct: 821 RRQRREREKELQFLE-EEEQLQRRE-RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 927 PRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKR 986
R + + QL K L Q L R + E +R
Sbjct: 879 EEERKRRRHTLYAKPALQEQLR----------KEQQLLQEEEEELQREEREKRRRQEQER 928
Query: 987 QLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILH 1046
Q +++ QQ E+ R E +++ E Q + D +L
Sbjct: 929 QYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK-------------EEQLLG 975
Query: 1047 HLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEK 1106
P R R E + + L+ + + ++++ E+
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD----ELQQEEE 1031
Query: 1107 MLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMRE 1166
L EK RL +ERE RQ EEE ++E+ + + RR+Q +E++ + E
Sbjct: 1032 QLLREEREKRRL---QERE----RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 1167 KQFSQARPLTRYLPIRK 1183
+ + L R P ++
Sbjct: 1085 ELQQEEEQLLREEPEKR 1101
Score = 57.4 bits (137), Expect = 9e-08
Identities = 134/650 (20%), Positives = 241/650 (37%), Gaps = 95/650 (14%)
Query: 573 RERK-NSITEISDNEDDLL----EYHRRQRQER-------LREQEMERLERQRLETILNL 620
RE+K E+ E+ LL E RRQ ER L+++E + L +R + L
Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE 1045
Query: 621 CAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESME 680
R + + E +GE R + L + E Q L E E
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERET------RRRQELERQYRKEEELQQEEEQLLREEPE 1099
Query: 681 RSDEENLKEECSSTESTQQEHE----DAPSTKLQGEVLALEEERAQVLGHVEQL------ 730
+ + + +C E QQE E + + + E+ E +V EQL
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159
Query: 731 KVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL---------- 780
K R +ELE+Q +E + E LL+ E+E R +++ + ++LQ +
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ 1219
Query: 781 ---VALETGIQKE---RDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSK 834
+ + +KE RD + E + F LE QL ++ + L G+ R +
Sbjct: 1220 RSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR 1279
Query: 835 AELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRY 894
+ R +R + Q+ + +E++R R QLL++E+E E+R
Sbjct: 1280 EQERRRWQQRDRHF----PEEEQLEREEQKEAKRRDRKSQEEKQLLREERE-----EKRR 1330
Query: 895 HSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGR 954
T R F + L+E PL R +L GR
Sbjct: 1331 RQET-DRKFREEEQLLQE--------REEQPLRR-------QERDRKFREEELRHQEQGR 1374
Query: 955 SPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAA- 1013
+ L R + ++ ++QL Q++ QQ+ +++ R+ E +Q+ +
Sbjct: 1375 KFLEEEQRL---------RRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425
Query: 1014 -------AEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAY--DT 1064
E + Q F H +ER E+ H D
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 1065 LSLESSDSM-----ETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLM 1119
LE + + + P+ + + + K L+E + R
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE-EQQLRRQE 1544
Query: 1120 ESREREMELRRQALEEERRRREQVERRL-QSESARRQQLVEKEVKMREKQ 1168
++R + R+ EEE+ R+E+ E++L + E R+ +L E++V+ +E++
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE 1594
Score = 51.2 bits (121), Expect = 6e-06
Identities = 108/477 (22%), Positives = 180/477 (37%), Gaps = 58/477 (12%)
Query: 573 RERKNSITEISDN----EDDLLEYHRRQRQERLREQEMERLERQR--LETILNLCAEYSR 626
+ER+ + + D E+ L R R+ R EQ++ R ER+R LE L E R
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461
Query: 627 ADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEEN 686
+ E + + L + R EE + Q + +
Sbjct: 1462 -----KFREEEQLLQEREEQQLHRQERDRKFL------EEEQQLRRQERDRKFREQELRS 1510
Query: 687 LKEECSSTESTQQEHEDAPSTK-LQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESA 745
+ E E QQ H K LQ E +ER Q K R E+QL++
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE---EEQLRQER 1567
Query: 746 REAEMERALLQGEREAERALLQKEQKAVDQLQEK-------LVALETGIQKERDKEAEAL 798
E ++ R +E +R +EQK Q QE+ + + G Q+ R +
Sbjct: 1568 EEQQLSR------QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621
Query: 799 ETETKLFEDLEFQQLERESR----VEEERELAGQGLLRSKAELLRSIAKRK---ERLAIL 851
+ +L ++ E QQL R+ R +EEE +L Q + + LR RK E +
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ----EREQQLRHDRDRKFREEEQLLQ 1677
Query: 852 DSQAGQIRAQ----AVQESERLARDKNASLQLLQKEKE-KLTVLERRYHSLTGGRPFPKT 906
+ + Q+R Q +E E+ R + + LQ+E++ + LER++ R +
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ 1737
Query: 907 TSTLK-EVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQ 965
+ E YR ++ E P + QL R + L +Q
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQL------RQEREEQQLRSQ 1791
Query: 966 NGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDA 1022
R Q+ E ++ Q+ G+ EE++ +L E +Q+ E Q+ A
Sbjct: 1792 ESDRKF-REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRA 1847
Score = 49.7 bits (117), Expect = 2e-05
Identities = 84/348 (24%), Positives = 156/348 (44%), Gaps = 41/348 (11%)
Query: 559 QRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERL--REQEMERLERQRLET 616
+RK + ++ R RK E E + + HR++R + EQ++ R ER R
Sbjct: 1445 ERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFR 1504
Query: 617 ILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLW 676
L ++ E +L +R + L +E G Q+
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHR-----------QQRQRKFLQEEQQLRRQERG---QQRR 1550
Query: 677 ESMERS--DEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRV 734
+ +R +EE L++E + ++QE + +L+ + + +E+ + + +QL R
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSRQERDR--KFRLEEQKVRRQEQERKFMEDEQQL--RR 1606
Query: 735 KELEQQL-QESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDK 793
+E +QQL QE R+ + LLQ ERE ++ Q+ + + + +L E Q D+
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQ-EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR 1665
Query: 794 EAEALETETKLFEDLEFQQLERESR----VEEERELAGQ----GLLRSKAELLRSIAKRK 845
+ + E E +L ++ E QQL R+ R EEE++L Q L+ + +L R +RK
Sbjct: 1666 DRKFRE-EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERK 1724
Query: 846 ---ERLAILDSQAGQIRAQ----AVQESERLARDKNASLQLLQKEKEK 886
E +++ Q+R Q + E E+L R + QL ++E+++
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQL-RPEREEQQLRRQERDR 1771
Score = 49.7 bits (117), Expect = 2e-05
Identities = 81/318 (25%), Positives = 132/318 (41%), Gaps = 32/318 (10%)
Query: 559 QRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETIL 618
Q + G ++ R+RK E E + + HR++R + E+E +L RQ E L
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE-PQLRRQEREQQL 1661
Query: 619 NLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGV---ATQRL 675
+ R E +L GE R R R E Q
Sbjct: 1662 ----RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717
Query: 676 WESMERS--DEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVR 733
+ +ER +EE L++E TE Q ++ L+ E L E E Q+ K R
Sbjct: 1718 RQELERKFREEEQLRQE---TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFR 1774
Query: 734 VKEL------EQQL--QESAREAEMERALLQGEREAERALLQKEQK-AVDQLQEKLVALE 784
+E EQQL QES R+ E L Q E + Q++ K ++ Q +L E
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834
Query: 785 TGIQKERDK-----EAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLR 839
+++ERD+ E A + +++ E +Q+ E++ R E ER+L + + R + E
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE--- 1891
Query: 840 SIAKRKERLAILDSQAGQ 857
+R ++ + SQ G+
Sbjct: 1892 --EQRHRQVGEIKSQEGK 1907
Score = 48.9 bits (115), Expect = 3e-05
Identities = 32/84 (38%), Positives = 46/84 (54%), Gaps = 2/84 (2%)
Query: 1103 EMEKMLKEAHAEKNRLMESREREMELRRQALE-EERRRREQVERRLQSESARRQQL-VEK 1160
+ E+ +E E+ E RE++ E R Q L E+ RREQ RR Q E R QQL E+
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368
Query: 1161 EVKMREKQFSQARPLTRYLPIRKE 1184
E + RE+Q + + L R +R+E
Sbjct: 369 EEERREQQLRREQQLRREQQLRRE 392
Score = 48.1 bits (113), Expect = 5e-05
Identities = 108/538 (20%), Positives = 201/538 (37%), Gaps = 77/538 (14%)
Query: 684 EENLKEECSSTESTQQEH-EDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQ 742
+E + C ES Q+ ++ + + LEEE Q + + + +E E++L
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQ------RRRQKRQEQERELA 149
Query: 743 ESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQ------------KE 790
E ++E + L Q +R+ L ++++ + +E+ A E +Q +E
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR-AEEEQLQSCKGHETEEFPDEE 208
Query: 791 RDKEAEALETETKLFEDLEFQQLERESRV---EEERELAG-QGLLRSKAELLRSIAKRKE 846
+ + E LE K E+ + Q+ ER+ RV EEE+E + +LR + E L+ +++
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 847 RLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKT 906
R L + Q+R QE L R++ Q Q+ + + + ++ + +
Sbjct: 269 RE--LQEEEEQLRKLERQE---LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323
Query: 907 TSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQN 966
+E + + + R L QL R + Q
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQL------RREQEEERREQQL 377
Query: 967 GTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGA 1026
R ++ + +R+ L+++ Q E+Q RR +L+++ + + +
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE----- 432
Query: 1027 APFPAGPSGFPPLMHHSILHHLPAGRER-GEEGEHAYDTLSLESSDSMETSISTGGNSAC 1085
H H +R E E D L E
Sbjct: 433 --------------RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478
Query: 1086 SPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRER-EMELRRQALEE--------- 1135
+ L K+EE E+ ++ E+ E ER E L+RQ EE
Sbjct: 479 DQEEERRERWL---KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 1136 ERRRREQVERRLQ---------SESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKE 1184
++ RREQ ERR Q E RR+Q +++E + R Q + R +++E
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE 593
Score = 45.8 bits (107), Expect = 3e-04
Identities = 30/105 (28%), Positives = 56/105 (53%), Gaps = 15/105 (14%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMES----REREMELRRQ------ALEEERRRREQVERRLQS 1149
K E E++L+E ++ R E RE E +LRRQ EE++ RR+++ER+ +
Sbjct: 1668 KFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE 1727
Query: 1150 ESARRQQLVEKEVKMREK-----QFSQARPLTRYLPIRKEDFDLK 1189
E RQ+ +++++ +E+ + Q RP +R+++ D K
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Score = 43.5 bits (101), Expect = 0.001
Identities = 78/351 (22%), Positives = 147/351 (41%), Gaps = 47/351 (13%)
Query: 566 DLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERL-ERQRLETILNLCAEY 624
DL+ E++N++ DN+ Y + + E+ R+ E +L +RQ + + +L E
Sbjct: 1222 DLKWQWEPEKENAVR---DNK----VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 625 SRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSD- 683
D E R + +S EE + + E R +
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 684 EENLKEECSSTESTQQEHEDAP------STKLQGEVLALEEERAQVLGHVEQLK------ 731
+ +EE E QE E+ P K + E L +E+ + L ++L+
Sbjct: 1335 DRKFREE----EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERER 1390
Query: 732 --------VRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQE-KLVA 782
+R +E EQQL++ E +E +R ++EQ+ Q +E K +
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450
Query: 783 LETGIQKERDKEAEALETETKLFEDLEFQQL---ERESRV-EEERELAGQGLLRS-KAEL 837
E +++ER ++ E +L ++ E QQL ER+ + EEE++L Q R + +
Sbjct: 1451 EEQQLRQERHRK---FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE 1507
Query: 838 LRSIAKRKERLAILDSQ---AGQIRAQAVQESERLARDKNASLQLLQKEKE 885
LRS + ER + + Q Q + + +QE ++L R + + ++++
Sbjct: 1508 LRS--QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Score = 43.5 bits (101), Expect = 0.001
Identities = 62/275 (22%), Positives = 108/275 (39%), Gaps = 18/275 (6%)
Query: 554 QSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQR 613
+ P ++R+ LR R+ + + + E+ L R R+ R EQ++ R ER+R
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707
Query: 614 LETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQ 673
L + R + + E + + T L + R + E +
Sbjct: 1708 --KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLR 1765
Query: 674 RLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVR 733
R + +EE L++E E Q +++ + E L E E Q+ K R
Sbjct: 1766 RQERDRKFREEEQLRQE---REEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR 1822
Query: 734 VKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDK 793
+E + QL+E + ER +R +EQ A QEK E + +E ++
Sbjct: 1823 WEEEQLQLEEQEQRLRQER---------DRQYRAEEQFAT---QEKSRREEQELWQEEEQ 1870
Query: 794 EAEALETETKLFEDLEFQQLERESRVEEERELAGQ 828
+ E E KL E+ +Q + E R + E+ Q
Sbjct: 1871 KRRQ-ERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
Score = 40.8 bits (94), Expect = 0.009
Identities = 63/308 (20%), Positives = 128/308 (41%), Gaps = 20/308 (6%)
Query: 584 DNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEAT 643
+ E+ L R R+ RL EQ++ R E++R + + R +G + +
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQER--KFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Query: 644 AALALAGRRPSRGLAGASGRS--SEEPGVATQRLWESMERSDEENLKEECSSTES--TQQ 699
L R + R EEP + Q + + + +EE + QQ
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ 1683
Query: 700 EHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAR-EAEMERALLQGE 758
K + E L + + E+ ++R +ELE++ +E + E E+ L+
Sbjct: 1684 LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLR-R 1742
Query: 759 REAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESR 818
+E R +L++EQ ++ +++L ++ERD++ E +L ++ E QQL +
Sbjct: 1743 QERYRKILEEEQLRPEREEQQL------RRQERDRK---FREEEQLRQEREEQQLRSQ-- 1791
Query: 819 VEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQ 878
E +R+ + LR + E + ++++ + + Q+ Q + + R A Q
Sbjct: 1792 -ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850
Query: 879 LLQKEKEK 886
+EK +
Sbjct: 1851 FATQEKSR 1858
Score = 37.7 bits (86), Expect = 0.073
Identities = 42/194 (21%), Positives = 85/194 (43%), Gaps = 22/194 (11%)
Query: 722 QVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLV 781
Q G E+ + R E LQ+ +E + R + + E ++ QK +Q +E
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 782 ALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEER----------------EL 825
E ++ER ++ + + +L+ + Q E R EEE+ +L
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 826 AGQGLL----RSKAELLRSIAKRKERLAILDSQAGQIRAQAV--QESERLARDKNASLQL 879
+ LL + + E + +R++R+ + + + + V +E E+L ++ +
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE 270
Query: 880 LQKEKEKLTVLERR 893
LQ+E+E+L LER+
Sbjct: 271 LQEEEEQLRKLERQ 284
Score = 37.7 bits (86), Expect = 0.073
Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 10/97 (10%)
Query: 1102 EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKE 1161
EE + L+E ++ RL + R+R+ Q +E+ RRE+ E + E RRQ E+E
Sbjct: 1824 EEEQLQLEE---QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQ---ERE 1877
Query: 1162 VKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHG 1198
K+RE+ + + + ++ ++K+ E GHG
Sbjct: 1878 RKLREEHIRRQQKEEQR---HRQVGEIKSQ-EGKGHG 1910
Score = 37.4 bits (85), Expect = 0.096
Identities = 27/88 (30%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 1102 EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKE 1161
E K+L+E R E + R E R+ EEE+ R+E+ E++L+S+ + R+ E++
Sbjct: 1744 ERYRKILEEEQLRPER-EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQ 1802
Query: 1162 VKMREKQFSQARPLTRYLPIRKEDFDLK 1189
++ +E++ Q RP R R E+ L+
Sbjct: 1803 LR-QEREEQQLRPQQRDGKYRWEEEQLQ 1829
Score = 36.6 bits (83), Expect = 0.16
Identities = 28/80 (35%), Positives = 45/80 (56%), Gaps = 16/80 (20%)
Query: 1100 KIEEMEKMLKEAHAEKNRLME-------SREREMELRRQALEEERRRREQVERRLQSESA 1152
++EE E+ L++ + R E SR E EL ++ EE++RR+E+ ER+L+ E
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE--EEQKRRQER-ERKLREEHI 1885
Query: 1153 RRQQLVEK------EVKMRE 1166
RRQQ E+ E+K +E
Sbjct: 1886 RRQQKEEQRHRQVGEIKSQE 1905
Score = 34.7 bits (78), Expect = 0.62
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 1/97 (1%)
Query: 1102 EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKE 1161
E E+ L+ + RE+++ +Q E++ RREQ RR Q +Q E+E
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430
Query: 1162 VKMREKQFSQARPLTRYLPIRKEDFD-LKTHIESSGH 1197
+ E++ Q R R ++E D LK E+ H
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERH 467
Score = 34.7 bits (78), Expect = 0.62
Identities = 21/93 (22%), Positives = 45/93 (48%), Gaps = 3/93 (3%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMES---REREMELRRQALEEERRRREQVERRLQSESARRQQ 1156
++E + +E E+ +L+ + R E RQ EEE ++E+ + + RR+Q
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 1157 LVEKEVKMREKQFSQARPLTRYLPIRKEDFDLK 1189
+E++ + E+ + L R P ++ +L+
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Score = 34.3 bits (77), Expect = 0.81
Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 2/70 (2%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMES--REREMELRRQALEEERRRREQVERRLQSESARRQQL 1157
KI E E++ E ++ R E + RE E RQ EE++ R ++ +R+ + E RQ+
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807
Query: 1158 VEKEVKMREK 1167
E++++ +++
Sbjct: 1808 EEQQLRPQQR 1817
Score = 33.9 bits (76), Expect = 1.1
Identities = 26/104 (25%), Positives = 53/104 (50%), Gaps = 7/104 (6%)
Query: 1101 IEEMEKMLKEAHAEKNRLMESRE-REMELRRQALEEERRRREQVER--RLQSESARRQQ- 1156
++E +++ ++ ++ R R+ RE E RQ EE++ R++ +R RL+ + RRQ+
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 1157 ---LVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGH 1197
+E E ++R ++ Q R R+++ L+ E H
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637
Score = 32.7 bits (73), Expect = 2.4
Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 10/101 (9%)
Query: 1105 EKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKM 1164
+++ +E E+ RE E E R Q L EE + EQ R++S + Q +E E
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQ--EQARERIKSRIPKWQWQLESEADA 714
Query: 1165 RE--------KQFSQARPLTRYLPIRKEDFDLKTHIESSGH 1197
R+ KQ Q R + R+ + +L+ E H
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAH 755
Score = 32.0 bits (71), Expect = 4.0
Identities = 24/99 (24%), Positives = 52/99 (52%), Gaps = 8/99 (8%)
Query: 1101 IEEMEKMLKEAHAEKNRLMESREREMELR----RQALEEERRRRE--QVERRLQSESARR 1154
+EE +++ ++ K R E R +E E + Q L ++R+R+ Q E++L+ + +
Sbjct: 1488 LEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547
Query: 1155 QQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIE 1193
Q+ +++ K RE++ Q R + +++ D K +E
Sbjct: 1548 QRRQDRDRKFREEE--QLRQEREEQQLSRQERDRKFRLE 1584
Score = 31.6 bits (70), Expect = 5.3
Identities = 22/82 (26%), Positives = 43/82 (52%), Gaps = 10/82 (12%)
Query: 1090 MSSASGLDMGK---IEEMEKMLKEAHAEKN-RLMESREREMELRRQALEEERRRREQVER 1145
+ A+GLD K + E +L++ E++ R E R+R++E EE +RR Q +
Sbjct: 89 LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLE------EEPGQRRRQKRQ 142
Query: 1146 RLQSESARRQQLVEKEVKMREK 1167
+ E A ++ EK+ ++ ++
Sbjct: 143 EQERELAEGEEQSEKQERLEQR 164
Score = 31.2 bits (69), Expect = 6.9
Identities = 21/70 (30%), Positives = 40/70 (57%), Gaps = 3/70 (4%)
Query: 1122 REREM-ELRRQALEE-ERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYL 1179
R RE+ ELRR+ EE +++RRE+ +R Q E + + E ++ E++ + P R
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP-QRQR 269
Query: 1180 PIRKEDFDLK 1189
+++E+ L+
Sbjct: 270 ELQEEEEQLR 279
Score = 31.2 bits (69), Expect = 6.9
Identities = 20/80 (25%), Positives = 41/80 (51%), Gaps = 8/80 (10%)
Query: 1102 EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSE--------SAR 1153
+E ++ +E + E + R E R+ EEE+ R+E+ E++L+ +
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEE 1826
Query: 1154 RQQLVEKEVKMREKQFSQAR 1173
+ QL E+E ++R+++ Q R
Sbjct: 1827 QLQLEEQEQRLRQERDRQYR 1846
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 73.2 bits (178), Expect = 2e-12
Identities = 119/437 (27%), Positives = 151/437 (34%), Gaps = 73/437 (16%)
Query: 146 PAGGRAPGPPYSPVPAESESLVNGNHTPQ---TATRGPSACASHSSLVSSIEKDLQEIMD 202
PA P PP + P +S S + + T + A R PSA S +
Sbjct: 183 PAPSARPRPP-TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS 241
Query: 203 SLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPA 262
S P A G A P P G + L P +P ++ +PA PLSS
Sbjct: 242 SPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR-------KDAAPALGPLSS-- 292
Query: 263 SSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERP 322
A+ SPS P PS PP + S PP + PS A + + + H
Sbjct: 293 --SPLATPSPSAP-PSPSAPPSLQTLPS-------PPATPPSQATTSLGSPTLQATHSFL 342
Query: 323 PSPGLRGLLT---DSPAATVLAEARR-------------ATESPRLGGQLPVVAISLS-- 364
PSP L L T +P A L + AT SP+ L V +
Sbjct: 343 PSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS 402
Query: 365 ---EYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSPS 421
P S P S P SP PP AP + PPSP PP S + +P
Sbjct: 403 PPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP---SATPP 459
Query: 422 RQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELP-------PLSPSLSRRALSPLPT 474
Q + L P P L L ++ P P SPS S +SPL T
Sbjct: 460 PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSAS-LPMSPLAT 518
Query: 475 RTTPDPKLNR----EVAESP-------RPRRWAAHGASPE------DFSLTLGARGRRTR 517
P + +V SP PRR G +L G +R
Sbjct: 519 PPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR 578
Query: 518 SPSPTL-GESLAPHKGS 533
SPS TL G LA H S
Sbjct: 579 SPSSTLSGPDLAGHSSS 595
Score = 67.8 bits (164), Expect = 7e-11
Identities = 126/453 (27%), Positives = 169/453 (37%), Gaps = 71/453 (15%)
Query: 143 SMIPAGGRAPGPPYSP-VPAESESLVNGNHTPQ----TATRGPSACASHSSL----VSSI 193
S P +P P SP P ++L + TP T+ P+ A+HS L +S +
Sbjct: 291 SSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPL 350
Query: 194 EKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSP 253
+ +L L P A P A+ PLSP+A P +P A++V SP
Sbjct: 351 ATPPPQAPPALALP-PLQAPPSPPASPPLSPLATPS------PQAPNALAVHLLQAPFSP 403
Query: 254 A--------FSPLSSPASSGSCASHS---PSGQEPGPSVPPLVPARSSSYHLALQPPQSR 302
FSP +SP S S S PS P VPP PA A PPQ+
Sbjct: 404 PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 463
Query: 303 PSGARSESPRLSRKGGHERPPS---PGLRGLLTDSPAATVLAEARRATESPRLGGQLPVV 359
P A P K + PP+ P L+ L SP A+ +A SP + +
Sbjct: 464 PPLAAP--PLQLAKPPPQAPPALATPPLQAL--PSPPASFPGQA---PFSPSASLPMSPL 516
Query: 360 AISLSEYP---ASGALSQPTSIPGSPKFQ----PPVPAPRNKIG----TLQDRPPSPFRE 408
A + P A+ L P S P SP Q PP P P + TL P P
Sbjct: 517 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP--- 573
Query: 409 PPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRE-----LPPLSPS 463
PP S SPS L G + ++ T P E RG DS E PP P
Sbjct: 574 PPPSR-----SPSSTLSGPDLAGHSSSATSTPEE-----LRGYDSGPEGGAAASPP--PD 621
Query: 464 LSRRALSPLPTRTTPDPKLN-REVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPT 522
A P P P L R +P P A S + G + +P+P
Sbjct: 622 AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 681
Query: 523 LGESLAPHKGSFSGRLSPAYSLGSLTGASPCQS 555
+ P G+ G+ + G+ + SP Q+
Sbjct: 682 ALDP-GPSPGTSGGKAAAGAGAGA-SSRSPKQA 712
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 72.4 bits (176), Expect = 3e-12
Identities = 161/707 (22%), Positives = 275/707 (38%), Gaps = 109/707 (15%)
Query: 558 VQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQR--QERLREQEMERLERQRLE 615
+QR+LS ++NS+ E +L+E H Q RLR E++R+E Q
Sbjct: 1290 LQRQLSQNQEEKSKWEGKQNSL------ESELMELHETMASLQSRLRRAELQRMEAQGER 1343
Query: 616 TILNLCAEYSRADGGP-EAGELPSIGEATAALALA-GRRPSRGLAGASGRSSEEPGVATQ 673
+L E A +A + + +A+AA L R +R E Q
Sbjct: 1344 ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQ 1403
Query: 674 RLWESMERSDEEN--LKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLK 731
L E E + L+E + T E E+ T L+G++ LE++R +E L
Sbjct: 1404 ALQEQGELKVAQGKALQENLALLTQTLAEREEEVET-LRGQIQELEKQREMQKAALELLS 1462
Query: 732 VRVKELEQQL---QESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQ 788
+ +K+ Q++ QE +E E R++L+ A+ ++EQK Q +E++ LE +
Sbjct: 1463 LDLKKRNQEVDLQQEQIQELEKCRSVLE---HLPMAVQEREQKLTVQ-REQIRELEKDRE 1518
Query: 789 KER----------DKEAEALETETKLFEDLEFQQLERES---RVEEE-----------RE 824
+R +K+ + +E++ +DL+ Q + E +EE +E
Sbjct: 1519 TQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKE 1578
Query: 825 LAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIR---------AQAVQESERLARDKNA 875
L GQ + A L +ER L +Q+ QI A+ +QE ++ + +
Sbjct: 1579 LEGQRETQRVA-LTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
Query: 876 SLQLLQKEKEKLTV-LERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPL 934
++ LQ++KE LT LERR L K + E R++ L + +
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELM----LQKERIQVLEDQRTRQTKILEEDLEQIK---- 1689
Query: 935 PSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKG 994
LS+ GR + + L+ + + A K L ++K
Sbjct: 1690 ------------LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKE 1737
Query: 995 QQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRER 1054
+ +E L ELK + + Q LH S I+ +E
Sbjct: 1738 VECQQEHIHELQELKDQLEQQLQ----GLHRKV---GETSLLLSQREQEIVVLQQQLQEA 1790
Query: 1055 GEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD----------MGKIEEM 1104
E+GE +L + ++ A G + G +E+
Sbjct: 1791 REQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA 1850
Query: 1105 EKMLKEAHAE-KNRLMESREREMEL-----RRQALEE-------ERRRREQVERRLQSES 1151
LKE H E ++ ++R E EL R QALEE E R +E+ LQ +
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQC 1910
Query: 1152 ARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFD-LKTHIESSGH 1197
A + Q E E + + + QA+ + L R ++ + L+ +SS H
Sbjct: 1911 AEQAQEHEVETRALQDSWLQAQAV---LKERDQELEALRAESQSSRH 1954
Score = 63.9 bits (154), Expect = 1e-09
Identities = 125/551 (22%), Positives = 211/551 (38%), Gaps = 64/551 (11%)
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
+ + E G ++ +S + L + E+ QQE + A QG+ ++E+
Sbjct: 1788 QEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA-----QGQEERVKEKADA 1842
Query: 723 VLGHVEQLKVRVKELEQQLQ---ESAREAEMERAL--------------LQGE-REAERA 764
+ G +EQ + +KE +LQ E AR E E A+ L+ E RE E+A
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKA 1902
Query: 765 LLQKEQKAVDQLQEKLV---ALE------TGIQKERDKEAEALETETKLFEDLEFQQLER 815
LL +Q+ +Q QE V AL+ + KERD+E EAL E++ E R
Sbjct: 1903 LLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARAR 1962
Query: 816 ESRVEEERELAGQGL------LRSKAELLRSIAKRKERL-AILDSQAGQIR----AQAVQ 864
++E A L L +AEL RS+ L A LD+ R A +Q
Sbjct: 1963 AEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQ 2022
Query: 865 ESE------RLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKM 918
E E R D Q L + E+L + R L +L + + M
Sbjct: 2023 EGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL---------EKSLAQRVQENM 2073
Query: 919 DGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAAT 978
E + L + R S QL++A + +N +LP + +
Sbjct: 2074 IQEKQN-LGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTS 2132
Query: 979 LQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPP 1038
+ ++ + +L+ + Q+ +E R A L+Q A E + + A A +
Sbjct: 2133 PMEEQSLKLDSLEPRLQRELE---RLQAALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189
Query: 1039 LMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDM 1098
L ++ ER E + D L L + + + G ++ + G+ +
Sbjct: 2190 LQEVAMFLQASV-LERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQL 2248
Query: 1099 GKIEEMEKMLKEAHAEKNRLMESRER-EMELRRQALEEERRRREQVERRLQSESARRQQL 1157
G++ +E EK + E + + R ++ R +R V+ R E R++
Sbjct: 2249 GEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERR 2308
Query: 1158 VEKEVKMREKQ 1168
K MR Q
Sbjct: 2309 KLKREAMRAAQ 2319
Score = 63.2 bits (152), Expect = 2e-09
Identities = 64/224 (28%), Positives = 108/224 (48%), Gaps = 24/224 (10%)
Query: 676 WESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVK 735
WE ++ + L++ ++ + D LQGEV +L +ER + E+L+ +++
Sbjct: 426 WEEEGKALRQRLQKLTGERDTLAGQTVD-----LQGEVDSLSKERELLQKAREELRQQLE 480
Query: 736 ELEQQLQESAR---EAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERD 792
LEQ+ R E +++ QG++E ++ L + ++LQE L+ LE
Sbjct: 481 VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEA------- 533
Query: 793 KEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILD 852
K++E+L L E LE LE E +E+ E+ + A +SIA+ L
Sbjct: 534 KQSESLSELITLREALESSHLEGELLRQEQTEVTA-----ALARAEQSIAELSSSENTLK 588
Query: 853 SQAGQIRAQAVQES---ERLARDK-NASLQLLQKEKEKLTVLER 892
++ +RA AV+ S E LA DK + QLLQ E+E +V R
Sbjct: 589 TEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSR 632
Score = 61.2 bits (147), Expect = 6e-09
Identities = 117/571 (20%), Positives = 231/571 (40%), Gaps = 99/571 (17%)
Query: 673 QRLWESME-----RSDEENLKEECSSTESTQ-QEHEDAPSTKLQGEVLALEEERAQVLGH 726
Q LW++ + R + L+E + TE+ + Q H + LQ ++ +EE+++ G
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQD--LQRQLSQNQEEKSKWEGK 1307
Query: 727 VEQLKVRVKELEQ---QLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLV-- 781
L+ + EL + LQ R AE++R QGERE +A + V+ LQ +V
Sbjct: 1308 QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEA 1367
Query: 782 ---ALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEEREL---AGQGLLRSKA 835
A GI +E + + KL + + ER ++E+ EL G+ L + A
Sbjct: 1368 RAQASAAGILEE---DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLA 1424
Query: 836 ELLRSIAKRKERLAILDSQAGQIRAQAVQES---ERLARDKNASLQLLQKEKEKLTVLER 892
L +++A+R+E + L Q ++ Q + E L+ D Q + ++E++ LE+
Sbjct: 1425 LLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEK 1484
Query: 893 -----RYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQL 947
+ + K T +++ + D E T+ L Q+
Sbjct: 1485 CRSVLEHLPMAVQEREQKLTVQREQIRELEKDRE-------TQRNVLEHQLLELEKKDQM 1537
Query: 948 SVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAE 1007
+ G+ K L+T L L +E +++L + +GQ+ E QR L
Sbjct: 1538 IESQRGQVQDLKKQLVTLE---CLALELEENHHKMECQQKLIKELEGQR--ETQRVALTH 1592
Query: 1008 LK---QKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSIL--------HHLPAGRERGE 1056
L ++ + E Q Q +H H ++L + + RE+ E
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLE------------SHSTVLARELQERDQEVKSQREQIE 1640
Query: 1057 EGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAE-- 1114
E + + L+ + + + D + + + +E+++ L+E E
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT 1700
Query: 1115 -KNRLMESR-------------------------EREMELRRQALEEERRRREQVERRLQ 1148
+ +LM+ R E+E+E +++ + E + ++Q+E++LQ
Sbjct: 1701 TQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQ 1760
Query: 1149 ------SESARRQQLVEKEVKMREKQFSQAR 1173
E++ E+E+ + ++Q +AR
Sbjct: 1761 GLHRKVGETSLLLSQREQEIVVLQQQLQEAR 1791
Score = 61.2 bits (147), Expect = 6e-09
Identities = 146/646 (22%), Positives = 243/646 (37%), Gaps = 124/646 (19%)
Query: 555 SPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLE-YHRRQRQERLREQEMERLERQR 613
S + R+L D V RE+ I E+ ++ L + RR ++ L+++ ++ LE QR
Sbjct: 1618 STVLARELQERDQEVKSQREQ---IEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQR 1674
Query: 614 LET--ILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVA 671
IL E + EL + + A G+ PS+ G+
Sbjct: 1675 TRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSL---------- 1724
Query: 672 TQRLWESMERSDEENLKE-ECSSTESTQ-QEHEDAPSTKLQGEVLALEEERAQVLGHVEQ 729
E M+ + KE EC + QE +D +LQG L + + + Q
Sbjct: 1725 -----EHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQG----LHRKVGETSLLLSQ 1775
Query: 730 LKVRVKELEQQLQESAREAEMERALLQGE-REAERALLQKEQKAVDQLQEKLVALETGIQ 788
+ + L+QQLQE+ + E++ LQ + EA+RAL Q++Q+ QE+ A Q
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG---Q 1832
Query: 789 KERDKE-AEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKER 847
+ER KE A+AL+ E ER +++ +E A L +A R
Sbjct: 1833 EERVKEKADALQ---GALEQAHMTLKERHGELQDHKEQA--------RRLEEELAVEGRR 1881
Query: 848 LAILDSQAGQIRAQA-VQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKT 906
+ L+ G +RA++ QE LA + + Q + E E + + + +
Sbjct: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQD----------SWLQA 1931
Query: 907 TSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQN 966
+ LKE R L + S SS A R
Sbjct: 1932 QAVLKE-----------------RDQELEALRAESQSSRHQEEAARAR------------ 1962
Query: 967 GTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDA---- 1022
A LQ+ K ALQ K Q ++E+ L+ + + A Q DA
Sbjct: 1963 ---------AEALQEALGKAHAALQGKEQHLLEQ--AELSRSLEASTATLQASLDACQAH 2011
Query: 1023 ---LHGAAPFPAGPSGFPPLMHHSILHHL-PAGRERGEEGEHAYDTLSLESSDSMETSIS 1078
L A G L + + L A +R EE H E +E S++
Sbjct: 2012 SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRH-----QQEREQLLEKSLA 2066
Query: 1079 TGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAH----AEKNRLMESREREMELRRQAL- 1133
+ + + +I + + ++E ++ ++E RE + +AL
Sbjct: 2067 QRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALP 2126
Query: 1134 --------EEERRRREQVERRLQSESARRQ----QLVEKEVKMREK 1167
EE+ + + +E RLQ E R Q Q +E++ REK
Sbjct: 2127 HSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREK 2172
Score = 55.8 bits (133), Expect = 3e-07
Identities = 85/382 (22%), Positives = 160/382 (41%), Gaps = 64/382 (16%)
Query: 558 VQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLRE-QEMERLERQRLET 616
+Q+KLS +++ + T++ + L + +RQ + R QE E L R++
Sbjct: 692 IQKKLSES------RHQQEAATTQL----EQLHQEAKRQEEVLARAVQEKEALVREKAAL 741
Query: 617 ILNLCA-EYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRL 675
+ L A E R D + L S E + ++ + + G+ + TQ
Sbjct: 742 EVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQA- 800
Query: 676 WESMERSDEENLKEECSSTESTQQEHEDAPSTKL----QGEVLALEEERAQVLGHVEQLK 731
+ + + + LK E + S ++ DA + +L Q ALE+++A V QL+
Sbjct: 801 -KEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLR 859
Query: 732 VR------------VKELEQ------QLQESAREAEMERALLQGEREAERALLQKE--QK 771
+ K LE +L+ +E + E +Q +RE ER + Q
Sbjct: 860 EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
Query: 772 AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRV--------EEER 823
++ +E++ LET +Q +++ A+A + +L +D++ Q+L+ + E +R
Sbjct: 920 QLETEKERVSLLETLLQTQKEL-ADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQR 978
Query: 824 ELA----------------GQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESE 867
EL LL+ K +L + + K +L D + Q VQE
Sbjct: 979 ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVE-QEVQEKL 1037
Query: 868 RLARDKNASLQLLQKEKEKLTV 889
R ++ N + L++EK LT+
Sbjct: 1038 RETQEYNRIQKELEREKASLTL 1059
Score = 55.5 bits (132), Expect = 3e-07
Identities = 139/612 (22%), Positives = 244/612 (39%), Gaps = 115/612 (18%)
Query: 596 QRQERLREQEMERLERQRL-ETILNLCAEYSRADGGPEAGELPSIGEATAALALAG---R 651
Q++E+ E + ER+RL E ++ L A+ S + EL ++ EA + L G R
Sbjct: 506 QKEEQQEELHLAVRERERLQEMLMGLEAKQSES-----LSELITLREALESSHLEGELLR 560
Query: 652 RPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQG 711
+ + A R+ E +A E+ +++ +L+ S E L
Sbjct: 561 QEQTEVTAALARA--EQSIAELSSSENTLKTEVADLRAAAVKL-SALNEALALDKVGLNQ 617
Query: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
++L LEEE V +E ++ LQ EAE R L + A LQK ++
Sbjct: 618 QLLQLEEENQSVCSRMEA----AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEE 673
Query: 772 AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
A +LQ L RD + E E + KL ESR ++E
Sbjct: 674 AGAELQADL----------RDIQEEKEEIQKKL----------SESRHQQE-------AA 706
Query: 832 RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNA---SLQLLQKEKEKLT 888
++ E L AKR+E ++ A+AVQE E L R+K A LQ ++++++ L
Sbjct: 707 TTQLEQLHQEAKRQE----------EVLARAVQEKEALVREKAALEVRLQAVERDRQDLA 756
Query: 889 VLERRYHSLTGGRPFPKTTSTLKEVYRSKM-DGEATSPLPRTRSGPLPSSSGSSSSSSQL 947
L G S+ KE+ S + + + + + G L + +Q
Sbjct: 757 ------EQLQG-------LSSAKELLESSLFEAQQQNSVIEVTKGQL---EVQIQTVTQA 800
Query: 948 SVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLA-LQQKGQQVIEEQR---- 1002
G K L T+ R+ AA RQLA +Q+G+ +E+Q+
Sbjct: 801 KEVIQGEVRCLKLELDTERSQAEQERDAAA--------RQLAQAEQEGKTALEQQKAAHE 852
Query: 1003 RRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPL-----MHHSILHHLPAGRERGE- 1056
+ + +L++K E + W A + L + + + A RE
Sbjct: 853 KEVNQLREK--WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT 910
Query: 1057 EGEHAYDTLSLESSDS----METSISTGGNSACSPDNM--------------SSASGLDM 1098
+ E A + LE+ +ET + T A + + +G+
Sbjct: 911 QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQ 970
Query: 1099 GKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLV 1158
+++E ++ LKEA + + + + E Q + +++ E ++ +L ++ Q+LV
Sbjct: 971 TQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD-DSQRLV 1029
Query: 1159 EKEV--KMREKQ 1168
E+EV K+RE Q
Sbjct: 1030 EQEVQEKLRETQ 1041
Score = 55.5 bits (132), Expect = 3e-07
Identities = 141/693 (20%), Positives = 280/693 (40%), Gaps = 97/693 (13%)
Query: 560 RKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLRE--QEMERLERQRLETI 617
R+L+ + E++ + E N+ L E ++R +E + +E LER+++E
Sbjct: 831 RQLAQAEQEGKTALEQQKAAHEKEVNQ--LREKWEKERSWHQQELAKALESLEREKMELE 888
Query: 618 LNLCAEYSRADG--GPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRL 675
+ L + + + E A + L + L ++ +E A+Q+L
Sbjct: 889 MRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQL 948
Query: 676 WESMERSDEENLKEECSS------TESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQ 729
+ + LKE+ ++ + Q+E ++A + + + ++ AL+EE + +L
Sbjct: 949 ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEA-ARQHRDDLAALQEESSSLLQDKMD 1007
Query: 730 LKVRVKEL--------------EQQLQESAREAEMERALLQGEREAERA-----LLQKEQ 770
L+ +V++L EQ++QE RE + E +Q E E E+A L++KEQ
Sbjct: 1008 LQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ-EYNRIQKELEREKASLTLSLMEKEQ 1066
Query: 771 KAV-----DQL-QEKLVALET------GIQKE------------RDKEAEALETETKLFE 806
+ + D + Q++L AL G QKE ++KEA+ L E +L E
Sbjct: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE 1126
Query: 807 DLEF-----QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKE---------RLAILD 852
+LE QQL +E + Q LRS L ++A ++ +LA L
Sbjct: 1127 ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLY 1186
Query: 853 SQAGQIRAQAVQESERLA--RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTL 910
S Q + L+ D S+ L+ ++ L +R LT S L
Sbjct: 1187 SALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLT-ALSAEAVASAL 1245
Query: 911 KEVYRSKMDGEATSPLPRTRSGPLPSS-SGSSSSSSQLSV------ATLGRSPSPKSALL 963
++++ + T + R + L + + + SQ+ L ++ KS
Sbjct: 1246 HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWE 1305
Query: 964 -TQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDA 1022
QN S L T+ ++++ L++ Q +E Q R EL Q A Q +
Sbjct: 1306 GKQNSLESELMELHETMASLQSR----LRRAELQRMEAQGER--ELLQAAKENLTAQVEH 1359
Query: 1023 LHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD---------TLSLESSDSM 1073
L A + ++ + A + + EE E + L + ++
Sbjct: 1360 LQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKAL 1419
Query: 1074 ETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQAL 1133
+ +++ + + + ++E+ +M K A + ++ R +E++L+++ +
Sbjct: 1420 QENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQI 1479
Query: 1134 EEERRRREQVERRLQSESARRQQLVEKEVKMRE 1166
+E + R +E + R Q+L + ++RE
Sbjct: 1480 QELEKCRSVLEHLPMAVQEREQKLTVQREQIRE 1512
Score = 42.0 bits (97), Expect = 0.004
Identities = 48/196 (24%), Positives = 83/196 (42%), Gaps = 17/196 (8%)
Query: 723 VLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVA 782
+L ++L+ E Q+L + + ++E+A LQ ALL + QK + ++ + A
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKA 308
Query: 783 LETGIQKERDKEAEALETETKLF-----EDLEFQQLER---ESRVEEERELAGQGLLRSK 834
L ++ E +E E L E L QQ+ + + VEE +A +
Sbjct: 309 LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENS 368
Query: 835 AELLRSIAKR-----KERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKE----KE 885
EL SI + ++ L R QAVQ+ + ++ LLQ++ +E
Sbjct: 369 LELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEE 428
Query: 886 KLTVLERRYHSLTGGR 901
+ L +R LTG R
Sbjct: 429 EGKALRQRLQKLTGER 444
Score = 31.2 bits (69), Expect = 6.9
Identities = 39/210 (18%), Positives = 79/210 (37%), Gaps = 32/210 (15%)
Query: 602 REQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGAS 661
R+ E +RL+ + T L E + G EL S GE L
Sbjct: 2204 RDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG-------------- 2249
Query: 662 GRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERA 721
E GV + + ME+ + EH +L+ + L+
Sbjct: 2250 ----EVSGVEAEPSPDGMEKQSWRQ-----------RLEHLQQAVARLEIDRSRLQRHNV 2294
Query: 722 QVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAE---RALLQKEQKAVDQLQE 778
Q+ +EQ++ ++L+++ +A+ +E + + R + K V +LQ+
Sbjct: 2295 QLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQK 2354
Query: 779 KLVALETGIQKERDKEAEALETETKLFEDL 808
++V L+ + ER ++ + + + +L
Sbjct: 2355 EVVLLQAQLTLERKQKQDYITRSAQTSREL 2384
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 72.0 bits (175), Expect = 4e-12
Identities = 100/408 (24%), Positives = 174/408 (42%), Gaps = 61/408 (14%)
Query: 587 DDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAAL 646
D+ E RRQ ++LR+ E+ER E ++ T+ + + ++ S G+
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE- 1667
Query: 647 ALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLK-----------EECSSTE 695
A+ R + R EE + + ++ S R E+ LK E +S
Sbjct: 1668 AVKQLRKMQAQMKELWREVEETRTSREEIF-SQNRESEKRLKGLEAEVLRLQEELAASDR 1726
Query: 696 STQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM----- 750
+ +Q +D ++ EV +A +L QL+ R+ +LE++L+E +E+
Sbjct: 1727 ARRQAQQD--RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRY 1784
Query: 751 ERALLQ-----GEREAERALLQKEQKAVDQLQEKLVAL-------ETGIQKERDKEAEAL 798
+ LLQ E AER+ K + QL+ ++ L + G + AL
Sbjct: 1785 RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAAL 1844
Query: 799 ETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDS----- 853
E++ E +QLE+E+R ER L+G+ + R++ L + + +E + D
Sbjct: 1845 ESKLAQAE----EQLEQETR---ERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQL 1897
Query: 854 QAGQIRA----QAVQESERLARDKNASLQLLQKEKEKLT-VLERRYHSLTGGR------P 902
+ G +R + ++E+E A A + LQ+E E +T E +T R P
Sbjct: 1898 EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGP 1957
Query: 903 FPKTTSTLKEVYRSK----MDGEATSPLPRTRSGPLPSSSGSSSSSSQ 946
TT T+++V+R + D EA P SGP P GS + Q
Sbjct: 1958 LTFTTRTVRQVFRLEEGVASDEEAEEAQP--GSGPSPEPEGSPPAHPQ 2003
Score = 69.7 bits (169), Expect = 2e-11
Identities = 137/661 (20%), Positives = 262/661 (39%), Gaps = 97/661 (14%)
Query: 599 ERLREQEMERLERQRLET-------------ILNLCAEYSRADGGPEAGELPSIGEATAA 645
ER R + E+L+R + E + L E S + + E A
Sbjct: 1297 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1356
Query: 646 LALAGR-RPSRGLAGASGRSSEEPGVATQRLWESMERSDEE------NLKEECSSTESTQ 698
LAL R R A EE A +R ++ + + +EE + E+ +
Sbjct: 1357 LALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE 1416
Query: 699 QEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGE 758
+ A E AL + A+ V++L+ + L+Q+L ++ + E +R L+
Sbjct: 1417 EARRRAAR-----EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLV--- 1468
Query: 759 REAERALLQKEQKAVDQL--QEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERE 816
+ L+K+Q+ DQL +EK L ++ER EAE E E + + E+E
Sbjct: 1469 -----STLEKKQRKFDQLLAEEKAAVLRAVEERER-AEAEGREREARALSLTRALEEEQE 1522
Query: 817 SRVEEERELAG-----QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLAR 871
+R E ER+ + LL SK ++ +S+ + + + + A +RAQ + + L
Sbjct: 1523 AREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1582
Query: 872 DKNASLQL--------LQKEK----------EKLTVLERRYHSLTGGRPFPKTTSTLKEV 913
++A L+L Q E+ E+ L ++ R + TL
Sbjct: 1583 AEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVA 1642
Query: 914 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQL-----SVATLGR----SPSPKSALLT 964
R K++GE L ++ + G + QL + L R + + + + +
Sbjct: 1643 ARKKLEGE----LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS 1698
Query: 965 QNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAE------LKQKAAAEAQC 1018
QN S R + + + +LA + ++ ++ R +A+ L + A E +
Sbjct: 1699 QN-RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1757
Query: 1019 QWDALHGAAPFPAGPSGFPP-----------LMHHSILHHLPAGRERGEEGEHAYDTLSL 1067
Q + G L S+ L A R + E L
Sbjct: 1758 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1817
Query: 1068 ESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEK---NRLMESRER 1124
+ + + + A + M+ A+ L+ K+ + E+ L++ E+ +L+ E+
Sbjct: 1818 QIQE-LRGRLGEEDAGARARHKMTIAA-LE-SKLAQAEEQLEQETRERILSGKLVRRAEK 1874
Query: 1125 EMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKE 1184
++ +EEERR +Q+ +L+ + R +QL +++++ E++ S+A+ R L E
Sbjct: 1875 RLKEVVLQVEEERRVADQLRDQLEKGNLRVKQL-KRQLEEAEEEASRAQAGRRRLQRELE 1933
Query: 1185 D 1185
D
Sbjct: 1934 D 1934
Score = 67.8 bits (164), Expect = 7e-11
Identities = 146/621 (23%), Positives = 245/621 (39%), Gaps = 88/621 (14%)
Query: 602 REQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGAS 661
R+ E+ + Q L+ + L + +R + G G + + E A LA R + A A
Sbjct: 874 RQDEVLQARAQELQKVQELQQQSAR-EVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 932
Query: 662 ---GRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEE 718
GR + + E R EE EECS T+++ +L+ + A E
Sbjct: 933 ETRGRLAARKQELELVVSELEARVGEE---EECSRQMQTEKKRLQQHIQELEAHLEAEEG 989
Query: 719 ERAQVLGHVEQLKVRVKELEQQL---QESAREAEMERALLQ---GEREAERALLQKEQKA 772
R ++ + ++K+ E+ L ++ + ER LL+ E ++ A +++ K+
Sbjct: 990 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1049
Query: 773 VDQLQEKLVA----LETGIQKERDKEAEALETETKL---FEDLEFQQLERESRVEEEREL 825
+++L+ K A +E ++KE E + + +L +L+ Q +E++ R EE R
Sbjct: 1050 LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ 1109
Query: 826 AGQGLLRSKAELLRSIAKRKERLAILDS----QAGQIRAQAVQESERLARDKNASLQLLQ 881
G+ +A L R+ + R +L S QA AQ ESER+AR K
Sbjct: 1110 LGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK-------- 1161
Query: 882 KEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSS 941
EK++ + E +L G ++ ++ RSK + E T L +T +
Sbjct: 1162 AEKQRRDLGEE-LEALRGELEDTLDSTNAQQELRSKREQEVTE-LKKTLEEETRIHEAAV 1219
Query: 942 SSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQ 1001
Q LG G R LA + E + +L+ Q +Q E++
Sbjct: 1220 QELRQRHGQALGELAEQLEQARRGKGAWEKTR-LALEAEVSELRAELSSLQTARQEGEQR 1278
Query: 1002 RRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHA 1061
RRRL + Q + G A R R E E
Sbjct: 1279 RRRL-----------ELQLQEVQGRAG--------------------DGERARAEAAE-- 1305
Query: 1062 YDTLSLESSDSMETSISTGGNSACSPD-NMSSASGLDMGKIEEMEKMLKEAHAEKNRLME 1120
L+ + + ++S N A S +S ++ + +++L+E K L
Sbjct: 1306 ----KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL-G 1360
Query: 1121 SREREMELR----RQALEEERRRREQVERRLQ------SESARRQQ----LVEKEVKMRE 1166
SR R ME R+ LEEE RE+ R LQ SE RRQ+ +E + R
Sbjct: 1361 SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARR 1420
Query: 1167 KQFSQARPLTRYLPIRKEDFD 1187
+ +A LT+ L + E D
Sbjct: 1421 RAAREAEALTQRLAEKTETVD 1441
Score = 60.5 bits (145), Expect = 1e-08
Identities = 108/488 (22%), Positives = 209/488 (42%), Gaps = 71/488 (14%)
Query: 588 DLLEYHRRQRQERLREQEME-RLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAAL 646
D LE RR+ Q+ L + M+ +RQ + T+ ++ + +A L ++ E A
Sbjct: 1441 DRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAE 1500
Query: 647 ALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQE-HE--- 702
A R +R L+ R+ EE A + L E R+ L+ SS + + HE
Sbjct: 1501 AEGREREARALSLT--RALEEEQEAREEL-ERQNRALRAELEALLSSKDDVGKSVHELER 1557
Query: 703 ------------DAPSTKLQGEVLALEEERAQVLGHVEQLKVRVK-----------ELEQ 739
A T+L+ E+ A E+ + ++ V+ LK + + E +
Sbjct: 1558 ACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRR 1617
Query: 740 QLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALE 799
QL + R+AE+ER + +R A +K + +++L+ ++ + G ++E K+ ++
Sbjct: 1618 QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG-KEEAVKQLRKMQ 1676
Query: 800 TETK-LFEDLEFQQLERE----SRVEEERELAG--QGLLRSKAELLRSIAKRKERLAILD 852
+ K L+ ++E + RE E E+ L G +LR + EL S R++ D
Sbjct: 1677 AQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRD 1736
Query: 853 SQA-----GQIRAQAVQESERLARDKNASL-QLLQKEKEKLTVLERRY-------HSLTG 899
A G + A+ E +R + L + L++E+ +L RY SLT
Sbjct: 1737 EMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTT 1796
Query: 900 GRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPK 959
++ S E R +++ + + G L + + ++++A L +
Sbjct: 1797 ELSAERSFSAKAESGRQQLERQI-----QELRGRLGEEDAGARARHKMTIAALESKLAQA 1851
Query: 960 SALLTQNG-----TGSLPRNLAATLQD----IETKRQLALQ-----QKGQQVIEEQRRRL 1005
L Q +G L R L++ +E +R++A Q +KG +++ +R+L
Sbjct: 1852 EEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQL 1911
Query: 1006 AELKQKAA 1013
E +++A+
Sbjct: 1912 EEAEEEAS 1919
Score = 57.0 bits (136), Expect = 1e-07
Identities = 111/507 (21%), Positives = 202/507 (39%), Gaps = 52/507 (10%)
Query: 684 EENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQE 743
E+ L++E E +QE E +L GE L+E+ + E+L+ ++ E++LQ
Sbjct: 1065 EDRLRKE----EKGRQELEKL-KRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQA 1119
Query: 744 SAREAEMERA----LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERD--KEAEA 797
+ AE E LL+ REA+ AL + A + L+ + VA ++ RD +E EA
Sbjct: 1120 ALARAEDEGGARAQLLKSLREAQAALAE----AQEDLESERVARTKAEKQRRDLGEELEA 1175
Query: 798 LETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQ 857
L E L + L+ ++E R + E+E+ K L + + L + GQ
Sbjct: 1176 LRGE--LEDTLDSTNAQQELRSKREQEVT-----ELKKTLEEETRIHEAAVQELRQRHGQ 1228
Query: 858 IRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSK 917
+ ++ E+ R K A + + +++ L SL R + E+ +
Sbjct: 1229 ALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQE 1288
Query: 918 MDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAA 977
+ G A R R+ + + +S A L + S L + + + A
Sbjct: 1289 VQGRAGDG-ERARAEAAEKLQRAQAELENVSGA-LNEAESKTIRLSKELSSTEAQLHDAQ 1346
Query: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAE---------AQCQWDALHGAAP 1028
L ET+ +LAL + + + E +L+++AAA AQ Q
Sbjct: 1347 ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQE 1406
Query: 1029 FPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPD 1088
AG L AG E + L+ ++ ET
Sbjct: 1407 EEAGA--------------LEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1452
Query: 1089 NMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQ 1148
+ A+ +D+ + ++ L++ + ++L+ + E+ LR EER R E R +
Sbjct: 1453 ELDDAT-MDLEQQRQLVSTLEKKQRKFDQLL-AEEKAAVLRAV---EERERAEAEGRERE 1507
Query: 1149 SESARRQQLVEKEVKMREKQFSQARPL 1175
+ + + +E+E + RE+ Q R L
Sbjct: 1508 ARALSLTRALEEEQEAREELERQNRAL 1534
Score = 53.5 bits (127), Expect = 1e-06
Identities = 145/666 (21%), Positives = 258/666 (38%), Gaps = 72/666 (10%)
Query: 550 ASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERL 609
+S Q V+++ + +LR + R+ + ++ ED+ R Q + LRE +
Sbjct: 1089 SSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE--GGARAQLLKSLREAQAALA 1146
Query: 610 ERQR---LETILNLCAEYSRADGGPEA----GELPSIGEATAALALAGRRPSRGLAGASG 662
E Q E + AE R D G E GEL ++T A + + +
Sbjct: 1147 EAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKK 1206
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
EE + + E +R + L E E ++ T+L ALE E ++
Sbjct: 1207 TLEEETRIHEAAVQELRQRHGQA-LGELAEQLEQARRGKGAWEKTRL-----ALEAEVSE 1260
Query: 723 VLGHVEQLKV-------RVKELEQQLQE-SAREAEMERALLQGEREAERAL--LQKEQKA 772
+ + L+ R + LE QLQE R + ERA + + +RA L+ A
Sbjct: 1261 LRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGA 1320
Query: 773 VDQLQEKLVAL-----ETGIQKERDKEAEALETETKLFEDLEFQQLERES-----RVEEE 822
+++ + K + L T Q +E ET KL + +E E+ ++EEE
Sbjct: 1321 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1380
Query: 823 ---RELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLAR---DKNAS 876
RE AG+ L ++A+L +++E L++ + R +A +E+E L + +K +
Sbjct: 1381 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEA-GEEARRRAAREAEALTQRLAEKTET 1439
Query: 877 LQLLQKEKEKL-TVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLP 935
+ L++ + +L L+ L R T + + + E + L
Sbjct: 1440 VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1499
Query: 936 SSSGSSSSSSQLSVA-TLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK- 993
+ G + LS+ L + L QN + +D K L++
Sbjct: 1500 EAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1559
Query: 994 --GQQVIEEQRRRLAELKQK--AAAEAQCQWDALHGAAPFP-----AGPSGFPPLMHHSI 1044
+Q + R ++ EL+ + AA +A+ + + A G +
Sbjct: 1560 RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQL 1619
Query: 1045 LHHL-PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD--MGKI 1101
L A ER EE + TL++ + +E G S+ G + + ++
Sbjct: 1620 AKQLRDAEVERDEERKQR--TLAVAARKKLE-----GELEELKAQMASAGQGKEEAVKQL 1672
Query: 1102 EEMEKMLKEAHAEKNRLMESRE------REMELRRQALEEERRRREQVERRLQSESARRQ 1155
+M+ +KE E SRE RE E R + LE E R + E S+ ARRQ
Sbjct: 1673 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQ--EELAASDRARRQ 1730
Query: 1156 QLVEKE 1161
+++
Sbjct: 1731 AQQDRD 1736
Score = 42.7 bits (99), Expect = 0.002
Identities = 140/666 (21%), Positives = 246/666 (36%), Gaps = 84/666 (12%)
Query: 586 EDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
ED L E+ + +E + + + +L + TI ++ + + G + E
Sbjct: 1030 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE---------- 1079
Query: 646 LALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAP 705
+ R L G S E+ QR + E + KEE + E E
Sbjct: 1080 ------KLKRRLDGESSELQEQMVEQQQR---AEELRAQLGRKEEELQAALARAEDEGGA 1130
Query: 706 STKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQ---GEREAE 762
+L + + A+ +E +V + E+Q ++ E E R L+ A+
Sbjct: 1131 RAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1190
Query: 763 RALLQKEQKAVDQ----LQEKLVALETGIQKERDKEAEALETETKLFEDL-------EFQ 811
+ L K ++ V + L+E+ E +Q+ R + +AL + E E
Sbjct: 1191 QELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1250
Query: 812 QLERESRVEEER-ELAGQGLLRSKAELLRSIAKRKERLAILDSQAG---QIRAQAVQESE 867
+L E+ V E R EL+ R + E R + + +L + +AG + RA+A ++ +
Sbjct: 1251 RLALEAEVSELRAELSSLQTARQEGEQRR--RRLELQLQEVQGRAGDGERARAEAAEKLQ 1308
Query: 868 RLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSK---------M 918
R + L + + K L + S L+E R+K M
Sbjct: 1309 RAQAELENVSGALNEAESKTIRLSKELSSTEA--QLHDAQELLQEETRAKLALGSRVRAM 1366
Query: 919 DGEATSPLPR-TRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAA 977
+ EA + +G ++Q ++ R ++ L G R AA
Sbjct: 1367 EAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE---AGEEARRRAA 1423
Query: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFP 1037
+ T+R LA + + +E RRRL + A + + Q + + F
Sbjct: 1424 REAEALTQR-LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLV---STLEKKQRKFD 1479
Query: 1038 PLMHHSILHHLPA--GRERGE------EGEHAYDTLSLESSDSMETSISTGGNSACSPDN 1089
L+ L A RER E E T +LE + + +
Sbjct: 1480 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1539
Query: 1090 MSSASGLDMGK-IEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRRE------- 1141
+S D+GK + E+E+ + A N L ++ E+E A E+ + R E
Sbjct: 1540 ALLSSKDDVGKSVHELERACRVAEQAANDL-RAQVTELEDELTAAEDAKLRLEVTVQALK 1598
Query: 1142 -QVERRLQ-----SESARRQ---QLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHI 1192
Q ER LQ E RRQ QL + EV+ E++ + + + E +LK +
Sbjct: 1599 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1658
Query: 1193 ESSGHG 1198
S+G G
Sbjct: 1659 ASAGQG 1664
Score = 41.2 bits (95), Expect = 0.007
Identities = 64/235 (27%), Positives = 105/235 (44%), Gaps = 20/235 (8%)
Query: 558 VQRKLSSGD-LRVPVTRERKNSITEISD---NEDDLLEYHRRQRQERLREQEMERLERQR 613
+Q +L++ D R ++R E+++ ++ +LE +RQ + RL + E E E Q
Sbjct: 1717 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE-EKRQLEGRLGQLEEELEEEQS 1775
Query: 614 LETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRP-SRGLAGASGRSSEEPGVAT 672
+LN EL S + +A A +GR+ R + GR EE A
Sbjct: 1776 NSELLNDRYRKLLLQVESLTTEL-SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGAR 1834
Query: 673 QR------LWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERA---QV 723
R ES EE L++E + + A +L+ VL +EEER Q+
Sbjct: 1835 ARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK-RLKEVVLQVEEERRVADQL 1893
Query: 724 LGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQE 778
+E+ +RVK+L++QL+E+ EA +A G R +R L + A +E
Sbjct: 1894 RDQLEKGNLRVKQLKRQLEEAEEEASRAQA---GRRRLQRELEDVTESAESMNRE 1945
Score = 32.0 bits (71), Expect = 4.0
Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 1111 AHAEKNR-LMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEK-----EVKM 1164
A AE+ R + +R++E+EL LE E+ R++Q+E R QQ +++ E +
Sbjct: 929 AEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE 988
Query: 1165 REKQFSQARPLTRYLPIRKEDFDL 1188
+Q Q +T ++K + DL
Sbjct: 989 GARQKLQLEKVTTEAKMKKFEEDL 1012
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 72.0 bits (175), Expect = 4e-12
Identities = 100/408 (24%), Positives = 174/408 (42%), Gaps = 61/408 (14%)
Query: 587 DDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAAL 646
D+ E RRQ ++LR+ E+ER E ++ T+ + + ++ S G+
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE- 1659
Query: 647 ALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLK-----------EECSSTE 695
A+ R + R EE + + ++ S R E+ LK E +S
Sbjct: 1660 AVKQLRKMQAQMKELWREVEETRTSREEIF-SQNRESEKRLKGLEAEVLRLQEELAASDR 1718
Query: 696 STQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM----- 750
+ +Q +D ++ EV +A +L QL+ R+ +LE++L+E +E+
Sbjct: 1719 ARRQAQQD--RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRY 1776
Query: 751 ERALLQ-----GEREAERALLQKEQKAVDQLQEKLVAL-------ETGIQKERDKEAEAL 798
+ LLQ E AER+ K + QL+ ++ L + G + AL
Sbjct: 1777 RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAAL 1836
Query: 799 ETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDS----- 853
E++ E +QLE+E+R ER L+G+ + R++ L + + +E + D
Sbjct: 1837 ESKLAQAE----EQLEQETR---ERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQL 1889
Query: 854 QAGQIRA----QAVQESERLARDKNASLQLLQKEKEKLT-VLERRYHSLTGGR------P 902
+ G +R + ++E+E A A + LQ+E E +T E +T R P
Sbjct: 1890 EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGP 1949
Query: 903 FPKTTSTLKEVYRSK----MDGEATSPLPRTRSGPLPSSSGSSSSSSQ 946
TT T+++V+R + D EA P SGP P GS + Q
Sbjct: 1950 LTFTTRTVRQVFRLEEGVASDEEAEEAQP--GSGPSPEPEGSPPAHPQ 1995
Score = 69.7 bits (169), Expect = 2e-11
Identities = 137/661 (20%), Positives = 262/661 (39%), Gaps = 97/661 (14%)
Query: 599 ERLREQEMERLERQRLET-------------ILNLCAEYSRADGGPEAGELPSIGEATAA 645
ER R + E+L+R + E + L E S + + E A
Sbjct: 1289 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1348
Query: 646 LALAGR-RPSRGLAGASGRSSEEPGVATQRLWESMERSDEE------NLKEECSSTESTQ 698
LAL R R A EE A +R ++ + + +EE + E+ +
Sbjct: 1349 LALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE 1408
Query: 699 QEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGE 758
+ A E AL + A+ V++L+ + L+Q+L ++ + E +R L+
Sbjct: 1409 EARRRAAR-----EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLV--- 1460
Query: 759 REAERALLQKEQKAVDQL--QEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERE 816
+ L+K+Q+ DQL +EK L ++ER EAE E E + + E+E
Sbjct: 1461 -----STLEKKQRKFDQLLAEEKAAVLRAVEERER-AEAEGREREARALSLTRALEEEQE 1514
Query: 817 SRVEEERELAG-----QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLAR 871
+R E ER+ + LL SK ++ +S+ + + + + A +RAQ + + L
Sbjct: 1515 AREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1574
Query: 872 DKNASLQL--------LQKEK----------EKLTVLERRYHSLTGGRPFPKTTSTLKEV 913
++A L+L Q E+ E+ L ++ R + TL
Sbjct: 1575 AEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVA 1634
Query: 914 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQL-----SVATLGR----SPSPKSALLT 964
R K++GE L ++ + G + QL + L R + + + + +
Sbjct: 1635 ARKKLEGE----LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS 1690
Query: 965 QNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAE------LKQKAAAEAQC 1018
QN S R + + + +LA + ++ ++ R +A+ L + A E +
Sbjct: 1691 QN-RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1749
Query: 1019 QWDALHGAAPFPAGPSGFPP-----------LMHHSILHHLPAGRERGEEGEHAYDTLSL 1067
Q + G L S+ L A R + E L
Sbjct: 1750 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1809
Query: 1068 ESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEK---NRLMESRER 1124
+ + + + A + M+ A+ L+ K+ + E+ L++ E+ +L+ E+
Sbjct: 1810 QIQE-LRGRLGEEDAGARARHKMTIAA-LE-SKLAQAEEQLEQETRERILSGKLVRRAEK 1866
Query: 1125 EMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKE 1184
++ +EEERR +Q+ +L+ + R +QL +++++ E++ S+A+ R L E
Sbjct: 1867 RLKEVVLQVEEERRVADQLRDQLEKGNLRVKQL-KRQLEEAEEEASRAQAGRRRLQRELE 1925
Query: 1185 D 1185
D
Sbjct: 1926 D 1926
Score = 67.8 bits (164), Expect = 7e-11
Identities = 146/621 (23%), Positives = 245/621 (39%), Gaps = 88/621 (14%)
Query: 602 REQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGAS 661
R+ E+ + Q L+ + L + +R + G G + + E A LA R + A A
Sbjct: 866 RQDEVLQARAQELQKVQELQQQSAR-EVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 924
Query: 662 ---GRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEE 718
GR + + E R EE EECS T+++ +L+ + A E
Sbjct: 925 ETRGRLAARKQELELVVSELEARVGEE---EECSRQMQTEKKRLQQHIQELEAHLEAEEG 981
Query: 719 ERAQVLGHVEQLKVRVKELEQQL---QESAREAEMERALLQ---GEREAERALLQKEQKA 772
R ++ + ++K+ E+ L ++ + ER LL+ E ++ A +++ K+
Sbjct: 982 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1041
Query: 773 VDQLQEKLVA----LETGIQKERDKEAEALETETKL---FEDLEFQQLERESRVEEEREL 825
+++L+ K A +E ++KE E + + +L +L+ Q +E++ R EE R
Sbjct: 1042 LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ 1101
Query: 826 AGQGLLRSKAELLRSIAKRKERLAILDS----QAGQIRAQAVQESERLARDKNASLQLLQ 881
G+ +A L R+ + R +L S QA AQ ESER+AR K
Sbjct: 1102 LGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK-------- 1153
Query: 882 KEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSS 941
EK++ + E +L G ++ ++ RSK + E T L +T +
Sbjct: 1154 AEKQRRDLGEE-LEALRGELEDTLDSTNAQQELRSKREQEVTE-LKKTLEEETRIHEAAV 1211
Query: 942 SSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQ 1001
Q LG G R LA + E + +L+ Q +Q E++
Sbjct: 1212 QELRQRHGQALGELAEQLEQARRGKGAWEKTR-LALEAEVSELRAELSSLQTARQEGEQR 1270
Query: 1002 RRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHA 1061
RRRL + Q + G A R R E E
Sbjct: 1271 RRRL-----------ELQLQEVQGRAG--------------------DGERARAEAAE-- 1297
Query: 1062 YDTLSLESSDSMETSISTGGNSACSPD-NMSSASGLDMGKIEEMEKMLKEAHAEKNRLME 1120
L+ + + ++S N A S +S ++ + +++L+E K L
Sbjct: 1298 ----KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL-G 1352
Query: 1121 SREREMELR----RQALEEERRRREQVERRLQ------SESARRQQ----LVEKEVKMRE 1166
SR R ME R+ LEEE RE+ R LQ SE RRQ+ +E + R
Sbjct: 1353 SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARR 1412
Query: 1167 KQFSQARPLTRYLPIRKEDFD 1187
+ +A LT+ L + E D
Sbjct: 1413 RAAREAEALTQRLAEKTETVD 1433
Score = 60.5 bits (145), Expect = 1e-08
Identities = 108/488 (22%), Positives = 209/488 (42%), Gaps = 71/488 (14%)
Query: 588 DLLEYHRRQRQERLREQEME-RLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAAL 646
D LE RR+ Q+ L + M+ +RQ + T+ ++ + +A L ++ E A
Sbjct: 1433 DRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAE 1492
Query: 647 ALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQE-HE--- 702
A R +R L+ R+ EE A + L E R+ L+ SS + + HE
Sbjct: 1493 AEGREREARALSLT--RALEEEQEAREEL-ERQNRALRAELEALLSSKDDVGKSVHELER 1549
Query: 703 ------------DAPSTKLQGEVLALEEERAQVLGHVEQLKVRVK-----------ELEQ 739
A T+L+ E+ A E+ + ++ V+ LK + + E +
Sbjct: 1550 ACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRR 1609
Query: 740 QLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALE 799
QL + R+AE+ER + +R A +K + +++L+ ++ + G ++E K+ ++
Sbjct: 1610 QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG-KEEAVKQLRKMQ 1668
Query: 800 TETK-LFEDLEFQQLERE----SRVEEERELAG--QGLLRSKAELLRSIAKRKERLAILD 852
+ K L+ ++E + RE E E+ L G +LR + EL S R++ D
Sbjct: 1669 AQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRD 1728
Query: 853 SQA-----GQIRAQAVQESERLARDKNASL-QLLQKEKEKLTVLERRY-------HSLTG 899
A G + A+ E +R + L + L++E+ +L RY SLT
Sbjct: 1729 EMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTT 1788
Query: 900 GRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPK 959
++ S E R +++ + + G L + + ++++A L +
Sbjct: 1789 ELSAERSFSAKAESGRQQLERQI-----QELRGRLGEEDAGARARHKMTIAALESKLAQA 1843
Query: 960 SALLTQNG-----TGSLPRNLAATLQD----IETKRQLALQ-----QKGQQVIEEQRRRL 1005
L Q +G L R L++ +E +R++A Q +KG +++ +R+L
Sbjct: 1844 EEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQL 1903
Query: 1006 AELKQKAA 1013
E +++A+
Sbjct: 1904 EEAEEEAS 1911
Score = 57.0 bits (136), Expect = 1e-07
Identities = 111/507 (21%), Positives = 202/507 (39%), Gaps = 52/507 (10%)
Query: 684 EENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQE 743
E+ L++E E +QE E +L GE L+E+ + E+L+ ++ E++LQ
Sbjct: 1057 EDRLRKE----EKGRQELEKL-KRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQA 1111
Query: 744 SAREAEMERA----LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERD--KEAEA 797
+ AE E LL+ REA+ AL + A + L+ + VA ++ RD +E EA
Sbjct: 1112 ALARAEDEGGARAQLLKSLREAQAALAE----AQEDLESERVARTKAEKQRRDLGEELEA 1167
Query: 798 LETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQ 857
L E L + L+ ++E R + E+E+ K L + + L + GQ
Sbjct: 1168 LRGE--LEDTLDSTNAQQELRSKREQEVT-----ELKKTLEEETRIHEAAVQELRQRHGQ 1220
Query: 858 IRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSK 917
+ ++ E+ R K A + + +++ L SL R + E+ +
Sbjct: 1221 ALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQE 1280
Query: 918 MDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAA 977
+ G A R R+ + + +S A L + S L + + + A
Sbjct: 1281 VQGRAGDG-ERARAEAAEKLQRAQAELENVSGA-LNEAESKTIRLSKELSSTEAQLHDAQ 1338
Query: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAE---------AQCQWDALHGAAP 1028
L ET+ +LAL + + + E +L+++AAA AQ Q
Sbjct: 1339 ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQE 1398
Query: 1029 FPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPD 1088
AG L AG E + L+ ++ ET
Sbjct: 1399 EEAGA--------------LEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1444
Query: 1089 NMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQ 1148
+ A+ +D+ + ++ L++ + ++L+ + E+ LR EER R E R +
Sbjct: 1445 ELDDAT-MDLEQQRQLVSTLEKKQRKFDQLL-AEEKAAVLRAV---EERERAEAEGRERE 1499
Query: 1149 SESARRQQLVEKEVKMREKQFSQARPL 1175
+ + + +E+E + RE+ Q R L
Sbjct: 1500 ARALSLTRALEEEQEAREELERQNRAL 1526
Score = 53.5 bits (127), Expect = 1e-06
Identities = 145/666 (21%), Positives = 258/666 (38%), Gaps = 72/666 (10%)
Query: 550 ASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERL 609
+S Q V+++ + +LR + R+ + ++ ED+ R Q + LRE +
Sbjct: 1081 SSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE--GGARAQLLKSLREAQAALA 1138
Query: 610 ERQR---LETILNLCAEYSRADGGPEA----GELPSIGEATAALALAGRRPSRGLAGASG 662
E Q E + AE R D G E GEL ++T A + + +
Sbjct: 1139 EAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKK 1198
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
EE + + E +R + L E E ++ T+L ALE E ++
Sbjct: 1199 TLEEETRIHEAAVQELRQRHGQA-LGELAEQLEQARRGKGAWEKTRL-----ALEAEVSE 1252
Query: 723 VLGHVEQLKV-------RVKELEQQLQE-SAREAEMERALLQGEREAERAL--LQKEQKA 772
+ + L+ R + LE QLQE R + ERA + + +RA L+ A
Sbjct: 1253 LRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGA 1312
Query: 773 VDQLQEKLVAL-----ETGIQKERDKEAEALETETKLFEDLEFQQLERES-----RVEEE 822
+++ + K + L T Q +E ET KL + +E E+ ++EEE
Sbjct: 1313 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1372
Query: 823 ---RELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLAR---DKNAS 876
RE AG+ L ++A+L +++E L++ + R +A +E+E L + +K +
Sbjct: 1373 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEA-GEEARRRAAREAEALTQRLAEKTET 1431
Query: 877 LQLLQKEKEKL-TVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLP 935
+ L++ + +L L+ L R T + + + E + L
Sbjct: 1432 VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1491
Query: 936 SSSGSSSSSSQLSVA-TLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK- 993
+ G + LS+ L + L QN + +D K L++
Sbjct: 1492 EAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1551
Query: 994 --GQQVIEEQRRRLAELKQK--AAAEAQCQWDALHGAAPFP-----AGPSGFPPLMHHSI 1044
+Q + R ++ EL+ + AA +A+ + + A G +
Sbjct: 1552 RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQL 1611
Query: 1045 LHHL-PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD--MGKI 1101
L A ER EE + TL++ + +E G S+ G + + ++
Sbjct: 1612 AKQLRDAEVERDEERKQR--TLAVAARKKLE-----GELEELKAQMASAGQGKEEAVKQL 1664
Query: 1102 EEMEKMLKEAHAEKNRLMESRE------REMELRRQALEEERRRREQVERRLQSESARRQ 1155
+M+ +KE E SRE RE E R + LE E R + E S+ ARRQ
Sbjct: 1665 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQ--EELAASDRARRQ 1722
Query: 1156 QLVEKE 1161
+++
Sbjct: 1723 AQQDRD 1728
Score = 42.7 bits (99), Expect = 0.002
Identities = 140/666 (21%), Positives = 246/666 (36%), Gaps = 84/666 (12%)
Query: 586 EDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
ED L E+ + +E + + + +L + TI ++ + + G + E
Sbjct: 1022 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE---------- 1071
Query: 646 LALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAP 705
+ R L G S E+ QR + E + KEE + E E
Sbjct: 1072 ------KLKRRLDGESSELQEQMVEQQQR---AEELRAQLGRKEEELQAALARAEDEGGA 1122
Query: 706 STKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQ---GEREAE 762
+L + + A+ +E +V + E+Q ++ E E R L+ A+
Sbjct: 1123 RAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1182
Query: 763 RALLQKEQKAVDQ----LQEKLVALETGIQKERDKEAEALETETKLFEDL-------EFQ 811
+ L K ++ V + L+E+ E +Q+ R + +AL + E E
Sbjct: 1183 QELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1242
Query: 812 QLERESRVEEER-ELAGQGLLRSKAELLRSIAKRKERLAILDSQAG---QIRAQAVQESE 867
+L E+ V E R EL+ R + E R + + +L + +AG + RA+A ++ +
Sbjct: 1243 RLALEAEVSELRAELSSLQTARQEGEQRR--RRLELQLQEVQGRAGDGERARAEAAEKLQ 1300
Query: 868 RLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSK---------M 918
R + L + + K L + S L+E R+K M
Sbjct: 1301 RAQAELENVSGALNEAESKTIRLSKELSSTEA--QLHDAQELLQEETRAKLALGSRVRAM 1358
Query: 919 DGEATSPLPR-TRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAA 977
+ EA + +G ++Q ++ R ++ L G R AA
Sbjct: 1359 EAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE---AGEEARRRAA 1415
Query: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFP 1037
+ T+R LA + + +E RRRL + A + + Q + + F
Sbjct: 1416 REAEALTQR-LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLV---STLEKKQRKFD 1471
Query: 1038 PLMHHSILHHLPA--GRERGE------EGEHAYDTLSLESSDSMETSISTGGNSACSPDN 1089
L+ L A RER E E T +LE + + +
Sbjct: 1472 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1531
Query: 1090 MSSASGLDMGK-IEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRRE------- 1141
+S D+GK + E+E+ + A N L ++ E+E A E+ + R E
Sbjct: 1532 ALLSSKDDVGKSVHELERACRVAEQAANDL-RAQVTELEDELTAAEDAKLRLEVTVQALK 1590
Query: 1142 -QVERRLQ-----SESARRQ---QLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHI 1192
Q ER LQ E RRQ QL + EV+ E++ + + + E +LK +
Sbjct: 1591 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1650
Query: 1193 ESSGHG 1198
S+G G
Sbjct: 1651 ASAGQG 1656
Score = 41.2 bits (95), Expect = 0.007
Identities = 64/235 (27%), Positives = 105/235 (44%), Gaps = 20/235 (8%)
Query: 558 VQRKLSSGD-LRVPVTRERKNSITEISD---NEDDLLEYHRRQRQERLREQEMERLERQR 613
+Q +L++ D R ++R E+++ ++ +LE +RQ + RL + E E E Q
Sbjct: 1709 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE-EKRQLEGRLGQLEEELEEEQS 1767
Query: 614 LETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRP-SRGLAGASGRSSEEPGVAT 672
+LN EL S + +A A +GR+ R + GR EE A
Sbjct: 1768 NSELLNDRYRKLLLQVESLTTEL-SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGAR 1826
Query: 673 QR------LWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERA---QV 723
R ES EE L++E + + A +L+ VL +EEER Q+
Sbjct: 1827 ARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK-RLKEVVLQVEEERRVADQL 1885
Query: 724 LGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQE 778
+E+ +RVK+L++QL+E+ EA +A G R +R L + A +E
Sbjct: 1886 RDQLEKGNLRVKQLKRQLEEAEEEASRAQA---GRRRLQRELEDVTESAESMNRE 1937
Score = 32.0 bits (71), Expect = 4.0
Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 1111 AHAEKNR-LMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEK-----EVKM 1164
A AE+ R + +R++E+EL LE E+ R++Q+E R QQ +++ E +
Sbjct: 921 AEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE 980
Query: 1165 REKQFSQARPLTRYLPIRKEDFDL 1188
+Q Q +T ++K + DL
Sbjct: 981 GARQKLQLEKVTTEAKMKKFEEDL 1004
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 72.0 bits (175), Expect = 4e-12
Identities = 100/408 (24%), Positives = 174/408 (42%), Gaps = 61/408 (14%)
Query: 587 DDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAAL 646
D+ E RRQ ++LR+ E+ER E ++ T+ + + ++ S G+
Sbjct: 1642 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE- 1700
Query: 647 ALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLK-----------EECSSTE 695
A+ R + R EE + + ++ S R E+ LK E +S
Sbjct: 1701 AVKQLRKMQAQMKELWREVEETRTSREEIF-SQNRESEKRLKGLEAEVLRLQEELAASDR 1759
Query: 696 STQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM----- 750
+ +Q +D ++ EV +A +L QL+ R+ +LE++L+E +E+
Sbjct: 1760 ARRQAQQD--RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRY 1817
Query: 751 ERALLQ-----GEREAERALLQKEQKAVDQLQEKLVAL-------ETGIQKERDKEAEAL 798
+ LLQ E AER+ K + QL+ ++ L + G + AL
Sbjct: 1818 RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAAL 1877
Query: 799 ETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDS----- 853
E++ E +QLE+E+R ER L+G+ + R++ L + + +E + D
Sbjct: 1878 ESKLAQAE----EQLEQETR---ERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQL 1930
Query: 854 QAGQIRA----QAVQESERLARDKNASLQLLQKEKEKLT-VLERRYHSLTGGR------P 902
+ G +R + ++E+E A A + LQ+E E +T E +T R P
Sbjct: 1931 EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGP 1990
Query: 903 FPKTTSTLKEVYRSK----MDGEATSPLPRTRSGPLPSSSGSSSSSSQ 946
TT T+++V+R + D EA P SGP P GS + Q
Sbjct: 1991 LTFTTRTVRQVFRLEEGVASDEEAEEAQP--GSGPSPEPEGSPPAHPQ 2036
Score = 69.7 bits (169), Expect = 2e-11
Identities = 137/661 (20%), Positives = 262/661 (39%), Gaps = 97/661 (14%)
Query: 599 ERLREQEMERLERQRLET-------------ILNLCAEYSRADGGPEAGELPSIGEATAA 645
ER R + E+L+R + E + L E S + + E A
Sbjct: 1330 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1389
Query: 646 LALAGR-RPSRGLAGASGRSSEEPGVATQRLWESMERSDEE------NLKEECSSTESTQ 698
LAL R R A EE A +R ++ + + +EE + E+ +
Sbjct: 1390 LALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE 1449
Query: 699 QEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGE 758
+ A E AL + A+ V++L+ + L+Q+L ++ + E +R L+
Sbjct: 1450 EARRRAAR-----EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLV--- 1501
Query: 759 REAERALLQKEQKAVDQL--QEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERE 816
+ L+K+Q+ DQL +EK L ++ER EAE E E + + E+E
Sbjct: 1502 -----STLEKKQRKFDQLLAEEKAAVLRAVEERER-AEAEGREREARALSLTRALEEEQE 1555
Query: 817 SRVEEERELAG-----QGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLAR 871
+R E ER+ + LL SK ++ +S+ + + + + A +RAQ + + L
Sbjct: 1556 AREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1615
Query: 872 DKNASLQL--------LQKEK----------EKLTVLERRYHSLTGGRPFPKTTSTLKEV 913
++A L+L Q E+ E+ L ++ R + TL
Sbjct: 1616 AEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVA 1675
Query: 914 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQL-----SVATLGR----SPSPKSALLT 964
R K++GE L ++ + G + QL + L R + + + + +
Sbjct: 1676 ARKKLEGE----LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS 1731
Query: 965 QNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAE------LKQKAAAEAQC 1018
QN S R + + + +LA + ++ ++ R +A+ L + A E +
Sbjct: 1732 QN-RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1790
Query: 1019 QWDALHGAAPFPAGPSGFPP-----------LMHHSILHHLPAGRERGEEGEHAYDTLSL 1067
Q + G L S+ L A R + E L
Sbjct: 1791 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1850
Query: 1068 ESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEK---NRLMESRER 1124
+ + + + A + M+ A+ L+ K+ + E+ L++ E+ +L+ E+
Sbjct: 1851 QIQE-LRGRLGEEDAGARARHKMTIAA-LE-SKLAQAEEQLEQETRERILSGKLVRRAEK 1907
Query: 1125 EMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKE 1184
++ +EEERR +Q+ +L+ + R +QL +++++ E++ S+A+ R L E
Sbjct: 1908 RLKEVVLQVEEERRVADQLRDQLEKGNLRVKQL-KRQLEEAEEEASRAQAGRRRLQRELE 1966
Query: 1185 D 1185
D
Sbjct: 1967 D 1967
Score = 67.8 bits (164), Expect = 7e-11
Identities = 146/621 (23%), Positives = 245/621 (39%), Gaps = 88/621 (14%)
Query: 602 REQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGAS 661
R+ E+ + Q L+ + L + +R + G G + + E A LA R + A A
Sbjct: 907 RQDEVLQARAQELQKVQELQQQSAR-EVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 965
Query: 662 ---GRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEE 718
GR + + E R EE EECS T+++ +L+ + A E
Sbjct: 966 ETRGRLAARKQELELVVSELEARVGEE---EECSRQMQTEKKRLQQHIQELEAHLEAEEG 1022
Query: 719 ERAQVLGHVEQLKVRVKELEQQL---QESAREAEMERALLQ---GEREAERALLQKEQKA 772
R ++ + ++K+ E+ L ++ + ER LL+ E ++ A +++ K+
Sbjct: 1023 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1082
Query: 773 VDQLQEKLVA----LETGIQKERDKEAEALETETKL---FEDLEFQQLERESRVEEEREL 825
+++L+ K A +E ++KE E + + +L +L+ Q +E++ R EE R
Sbjct: 1083 LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ 1142
Query: 826 AGQGLLRSKAELLRSIAKRKERLAILDS----QAGQIRAQAVQESERLARDKNASLQLLQ 881
G+ +A L R+ + R +L S QA AQ ESER+AR K
Sbjct: 1143 LGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK-------- 1194
Query: 882 KEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSS 941
EK++ + E +L G ++ ++ RSK + E T L +T +
Sbjct: 1195 AEKQRRDLGEE-LEALRGELEDTLDSTNAQQELRSKREQEVTE-LKKTLEEETRIHEAAV 1252
Query: 942 SSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQ 1001
Q LG G R LA + E + +L+ Q +Q E++
Sbjct: 1253 QELRQRHGQALGELAEQLEQARRGKGAWEKTR-LALEAEVSELRAELSSLQTARQEGEQR 1311
Query: 1002 RRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHA 1061
RRRL + Q + G A R R E E
Sbjct: 1312 RRRL-----------ELQLQEVQGRAG--------------------DGERARAEAAE-- 1338
Query: 1062 YDTLSLESSDSMETSISTGGNSACSPD-NMSSASGLDMGKIEEMEKMLKEAHAEKNRLME 1120
L+ + + ++S N A S +S ++ + +++L+E K L
Sbjct: 1339 ----KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL-G 1393
Query: 1121 SREREMELR----RQALEEERRRREQVERRLQ------SESARRQQ----LVEKEVKMRE 1166
SR R ME R+ LEEE RE+ R LQ SE RRQ+ +E + R
Sbjct: 1394 SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARR 1453
Query: 1167 KQFSQARPLTRYLPIRKEDFD 1187
+ +A LT+ L + E D
Sbjct: 1454 RAAREAEALTQRLAEKTETVD 1474
Score = 60.5 bits (145), Expect = 1e-08
Identities = 108/488 (22%), Positives = 209/488 (42%), Gaps = 71/488 (14%)
Query: 588 DLLEYHRRQRQERLREQEME-RLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAAL 646
D LE RR+ Q+ L + M+ +RQ + T+ ++ + +A L ++ E A
Sbjct: 1474 DRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAE 1533
Query: 647 ALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQE-HE--- 702
A R +R L+ R+ EE A + L E R+ L+ SS + + HE
Sbjct: 1534 AEGREREARALSLT--RALEEEQEAREEL-ERQNRALRAELEALLSSKDDVGKSVHELER 1590
Query: 703 ------------DAPSTKLQGEVLALEEERAQVLGHVEQLKVRVK-----------ELEQ 739
A T+L+ E+ A E+ + ++ V+ LK + + E +
Sbjct: 1591 ACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRR 1650
Query: 740 QLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALE 799
QL + R+AE+ER + +R A +K + +++L+ ++ + G ++E K+ ++
Sbjct: 1651 QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG-KEEAVKQLRKMQ 1709
Query: 800 TETK-LFEDLEFQQLERE----SRVEEERELAG--QGLLRSKAELLRSIAKRKERLAILD 852
+ K L+ ++E + RE E E+ L G +LR + EL S R++ D
Sbjct: 1710 AQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRD 1769
Query: 853 SQA-----GQIRAQAVQESERLARDKNASL-QLLQKEKEKLTVLERRY-------HSLTG 899
A G + A+ E +R + L + L++E+ +L RY SLT
Sbjct: 1770 EMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTT 1829
Query: 900 GRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPK 959
++ S E R +++ + + G L + + ++++A L +
Sbjct: 1830 ELSAERSFSAKAESGRQQLERQI-----QELRGRLGEEDAGARARHKMTIAALESKLAQA 1884
Query: 960 SALLTQNG-----TGSLPRNLAATLQD----IETKRQLALQ-----QKGQQVIEEQRRRL 1005
L Q +G L R L++ +E +R++A Q +KG +++ +R+L
Sbjct: 1885 EEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQL 1944
Query: 1006 AELKQKAA 1013
E +++A+
Sbjct: 1945 EEAEEEAS 1952
Score = 57.0 bits (136), Expect = 1e-07
Identities = 111/507 (21%), Positives = 202/507 (39%), Gaps = 52/507 (10%)
Query: 684 EENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQE 743
E+ L++E E +QE E +L GE L+E+ + E+L+ ++ E++LQ
Sbjct: 1098 EDRLRKE----EKGRQELEKL-KRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQA 1152
Query: 744 SAREAEMERA----LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERD--KEAEA 797
+ AE E LL+ REA+ AL + A + L+ + VA ++ RD +E EA
Sbjct: 1153 ALARAEDEGGARAQLLKSLREAQAALAE----AQEDLESERVARTKAEKQRRDLGEELEA 1208
Query: 798 LETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQ 857
L E L + L+ ++E R + E+E+ K L + + L + GQ
Sbjct: 1209 LRGE--LEDTLDSTNAQQELRSKREQEVT-----ELKKTLEEETRIHEAAVQELRQRHGQ 1261
Query: 858 IRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSK 917
+ ++ E+ R K A + + +++ L SL R + E+ +
Sbjct: 1262 ALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQE 1321
Query: 918 MDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAA 977
+ G A R R+ + + +S A L + S L + + + A
Sbjct: 1322 VQGRAGDG-ERARAEAAEKLQRAQAELENVSGA-LNEAESKTIRLSKELSSTEAQLHDAQ 1379
Query: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAE---------AQCQWDALHGAAP 1028
L ET+ +LAL + + + E +L+++AAA AQ Q
Sbjct: 1380 ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQE 1439
Query: 1029 FPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPD 1088
AG L AG E + L+ ++ ET
Sbjct: 1440 EEAGA--------------LEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1485
Query: 1089 NMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQ 1148
+ A+ +D+ + ++ L++ + ++L+ + E+ LR EER R E R +
Sbjct: 1486 ELDDAT-MDLEQQRQLVSTLEKKQRKFDQLL-AEEKAAVLRAV---EERERAEAEGRERE 1540
Query: 1149 SESARRQQLVEKEVKMREKQFSQARPL 1175
+ + + +E+E + RE+ Q R L
Sbjct: 1541 ARALSLTRALEEEQEAREELERQNRAL 1567
Score = 53.5 bits (127), Expect = 1e-06
Identities = 145/666 (21%), Positives = 258/666 (38%), Gaps = 72/666 (10%)
Query: 550 ASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERL 609
+S Q V+++ + +LR + R+ + ++ ED+ R Q + LRE +
Sbjct: 1122 SSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE--GGARAQLLKSLREAQAALA 1179
Query: 610 ERQR---LETILNLCAEYSRADGGPEA----GELPSIGEATAALALAGRRPSRGLAGASG 662
E Q E + AE R D G E GEL ++T A + + +
Sbjct: 1180 EAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKK 1239
Query: 663 RSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQ 722
EE + + E +R + L E E ++ T+L ALE E ++
Sbjct: 1240 TLEEETRIHEAAVQELRQRHGQA-LGELAEQLEQARRGKGAWEKTRL-----ALEAEVSE 1293
Query: 723 VLGHVEQLKV-------RVKELEQQLQE-SAREAEMERALLQGEREAERAL--LQKEQKA 772
+ + L+ R + LE QLQE R + ERA + + +RA L+ A
Sbjct: 1294 LRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGA 1353
Query: 773 VDQLQEKLVAL-----ETGIQKERDKEAEALETETKLFEDLEFQQLERES-----RVEEE 822
+++ + K + L T Q +E ET KL + +E E+ ++EEE
Sbjct: 1354 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1413
Query: 823 ---RELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLAR---DKNAS 876
RE AG+ L ++A+L +++E L++ + R +A +E+E L + +K +
Sbjct: 1414 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEA-GEEARRRAAREAEALTQRLAEKTET 1472
Query: 877 LQLLQKEKEKL-TVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLP 935
+ L++ + +L L+ L R T + + + E + L
Sbjct: 1473 VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1532
Query: 936 SSSGSSSSSSQLSVA-TLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK- 993
+ G + LS+ L + L QN + +D K L++
Sbjct: 1533 EAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1592
Query: 994 --GQQVIEEQRRRLAELKQK--AAAEAQCQWDALHGAAPFP-----AGPSGFPPLMHHSI 1044
+Q + R ++ EL+ + AA +A+ + + A G +
Sbjct: 1593 RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQL 1652
Query: 1045 LHHL-PAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLD--MGKI 1101
L A ER EE + TL++ + +E G S+ G + + ++
Sbjct: 1653 AKQLRDAEVERDEERKQR--TLAVAARKKLE-----GELEELKAQMASAGQGKEEAVKQL 1705
Query: 1102 EEMEKMLKEAHAEKNRLMESRE------REMELRRQALEEERRRREQVERRLQSESARRQ 1155
+M+ +KE E SRE RE E R + LE E R + E S+ ARRQ
Sbjct: 1706 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQ--EELAASDRARRQ 1763
Query: 1156 QLVEKE 1161
+++
Sbjct: 1764 AQQDRD 1769
Score = 42.7 bits (99), Expect = 0.002
Identities = 140/666 (21%), Positives = 246/666 (36%), Gaps = 84/666 (12%)
Query: 586 EDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAA 645
ED L E+ + +E + + + +L + TI ++ + + G + E
Sbjct: 1063 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE---------- 1112
Query: 646 LALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAP 705
+ R L G S E+ QR + E + KEE + E E
Sbjct: 1113 ------KLKRRLDGESSELQEQMVEQQQR---AEELRAQLGRKEEELQAALARAEDEGGA 1163
Query: 706 STKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQ---GEREAE 762
+L + + A+ +E +V + E+Q ++ E E R L+ A+
Sbjct: 1164 RAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1223
Query: 763 RALLQKEQKAVDQ----LQEKLVALETGIQKERDKEAEALETETKLFEDL-------EFQ 811
+ L K ++ V + L+E+ E +Q+ R + +AL + E E
Sbjct: 1224 QELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1283
Query: 812 QLERESRVEEER-ELAGQGLLRSKAELLRSIAKRKERLAILDSQAG---QIRAQAVQESE 867
+L E+ V E R EL+ R + E R + + +L + +AG + RA+A ++ +
Sbjct: 1284 RLALEAEVSELRAELSSLQTARQEGEQRR--RRLELQLQEVQGRAGDGERARAEAAEKLQ 1341
Query: 868 RLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSK---------M 918
R + L + + K L + S L+E R+K M
Sbjct: 1342 RAQAELENVSGALNEAESKTIRLSKELSSTEA--QLHDAQELLQEETRAKLALGSRVRAM 1399
Query: 919 DGEATSPLPR-TRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAA 977
+ EA + +G ++Q ++ R ++ L G R AA
Sbjct: 1400 EAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE---AGEEARRRAA 1456
Query: 978 TLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFP 1037
+ T+R LA + + +E RRRL + A + + Q + + F
Sbjct: 1457 REAEALTQR-LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLV---STLEKKQRKFD 1512
Query: 1038 PLMHHSILHHLPA--GRERGE------EGEHAYDTLSLESSDSMETSISTGGNSACSPDN 1089
L+ L A RER E E T +LE + + +
Sbjct: 1513 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1572
Query: 1090 MSSASGLDMGK-IEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRRE------- 1141
+S D+GK + E+E+ + A N L ++ E+E A E+ + R E
Sbjct: 1573 ALLSSKDDVGKSVHELERACRVAEQAANDL-RAQVTELEDELTAAEDAKLRLEVTVQALK 1631
Query: 1142 -QVERRLQ-----SESARRQ---QLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHI 1192
Q ER LQ E RRQ QL + EV+ E++ + + + E +LK +
Sbjct: 1632 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1691
Query: 1193 ESSGHG 1198
S+G G
Sbjct: 1692 ASAGQG 1697
Score = 41.2 bits (95), Expect = 0.007
Identities = 64/235 (27%), Positives = 105/235 (44%), Gaps = 20/235 (8%)
Query: 558 VQRKLSSGD-LRVPVTRERKNSITEISD---NEDDLLEYHRRQRQERLREQEMERLERQR 613
+Q +L++ D R ++R E+++ ++ +LE +RQ + RL + E E E Q
Sbjct: 1750 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE-EKRQLEGRLGQLEEELEEEQS 1808
Query: 614 LETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRP-SRGLAGASGRSSEEPGVAT 672
+LN EL S + +A A +GR+ R + GR EE A
Sbjct: 1809 NSELLNDRYRKLLLQVESLTTEL-SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGAR 1867
Query: 673 QR------LWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERA---QV 723
R ES EE L++E + + A +L+ VL +EEER Q+
Sbjct: 1868 ARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK-RLKEVVLQVEEERRVADQL 1926
Query: 724 LGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQE 778
+E+ +RVK+L++QL+E+ EA +A G R +R L + A +E
Sbjct: 1927 RDQLEKGNLRVKQLKRQLEEAEEEASRAQA---GRRRLQRELEDVTESAESMNRE 1978
Score = 32.0 bits (71), Expect = 4.0
Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 6/84 (7%)
Query: 1111 AHAEKNR-LMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEK-----EVKM 1164
A AE+ R + +R++E+EL LE E+ R++Q+E R QQ +++ E +
Sbjct: 962 AEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE 1021
Query: 1165 REKQFSQARPLTRYLPIRKEDFDL 1188
+Q Q +T ++K + DL
Sbjct: 1022 GARQKLQLEKVTTEAKMKKFEEDL 1045
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 71.6 bits (174), Expect = 5e-12
Identities = 125/555 (22%), Positives = 241/555 (43%), Gaps = 83/555 (14%)
Query: 670 VATQRLWESM--ERSDE-ENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGH 726
V Q L ++M ER E E LK+EC +S Q +A ++L+ E+ +E A +
Sbjct: 231 VQVQTLMDNMTLERERESEKLKDECKKLQS-QYASSEATISQLRSELAKGPQEVAVYVQE 289
Query: 727 VEQLKVRVKELEQQ---LQESAREAEMERALLQGEREAE-------RALLQKEQKAVDQL 776
+++LK V EL Q+ L E+ + E + L+ + E +A L ++ QL
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 777 QEKLVALETGIQKERDKEAEALETETKLFEDL-----EFQQLERE-SRVEEERELAGQGL 830
Q +L A ET + + + +E E KL E+L ++Q L+ E +++++RE Q
Sbjct: 350 QSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHG 409
Query: 831 LRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERL------ARDKNASLQLLQKE- 883
L+ ++E+ + +K E L G+++ Q SE+L D L L+++
Sbjct: 410 LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQL 469
Query: 884 KEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS 943
KEK+T H L + + L++ +K+ EA + L + + G
Sbjct: 470 KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKL-REAQNDLEQ-----VLRQIGDKDQ 523
Query: 944 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQ--DIETKRQLALQQKGQQVIEEQ 1001
Q A L +S S L + +L A +Q + ET LQ+K + E+
Sbjct: 524 KIQNLEALLQKSKENISLLEKER------EDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577
Query: 1002 RRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHA 1061
+ +LK ++ + Q Q + LH HL A ++R
Sbjct: 578 TQLTEKLKNQSESHKQAQ-ENLHDQVQEQKA--------------HLRAAQDR------- 615
Query: 1062 YDTLSLESS-DSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLME 1120
LSLE+S + + + ++ ++ S LD+ +I+ ++L A A K
Sbjct: 616 --VLSLETSVNELNSQLN---------ESKEKVSQLDI-QIKAKTELLLSAEAAKTAQRA 663
Query: 1121 SREREMELRRQALEEERRRREQVERRLQSESARRQQLVE--KEVKMREKQFSQARPLTRY 1178
+ ++ + AL+++++ ++ +L +A+ Q E +++ K++ + +Y
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE-----KY 718
Query: 1179 LPIRKEDFDLKTHIE 1193
L + ++ +L+ I+
Sbjct: 719 LSLEQKTEELEGQIK 733
Score = 60.1 bits (144), Expect = 1e-08
Identities = 110/562 (19%), Positives = 228/562 (40%), Gaps = 77/562 (13%)
Query: 672 TQRLWESMERSD--EENLKEECSSTESTQQEHEDAPST--KLQGEVLALEEERAQVLGHV 727
T +L + E E +LKE S +Q+ E+ KL+ + L ++ + Q L +
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753
Query: 728 EQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGI 787
+Q + +LE + E +++ EME+ ++ + R LQK+ +A++ +++KL E
Sbjct: 754 QQQRQLNTDLELRATELSKQLEMEKEIV----SSTRLDLQKKSEALESIKQKLTKQEEEK 809
Query: 788 QKERDKEAEALETETKL-FEDL---------EFQQLERE--------SRVEEERELAGQG 829
Q + ++ E L ETK+ E+L E Q+++ E S V+++
Sbjct: 810 QILK-QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 868
Query: 830 LLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKE---- 885
L SK+E + K K + L+ +++ Q + E +++ + L+KEKE
Sbjct: 869 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ 928
Query: 886 -----------------KLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGE------- 921
L E+ L G K +S K+ + GE
Sbjct: 929 LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ 988
Query: 922 ATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQD 981
T + + ++ ++ ++SV S ++ Q+ L AT QD
Sbjct: 989 KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD 1048
Query: 982 IET-KRQLALQQK----GQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGF 1036
+++ + +L+L Q+ + I Q + + ELK A+A + D+
Sbjct: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK---TAKATLEQDSAKKEQQLQERCKAL 1105
Query: 1037 PPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGL 1096
+ L E+ + E +E + T N + S
Sbjct: 1106 QDIQKEKSLKEKELVNEKSKLAE-------IEEIKCRQEKEITKLNEELKSHKLESIK-- 1156
Query: 1097 DMGKIEEMEKMLKEAHAEKNRLMESRER--EMELRRQALEEERRRREQVERR---LQSES 1151
++ +++ +++L + E +S + E E R Q + +++ ++E+ E + ++ E+
Sbjct: 1157 EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEA 1216
Query: 1152 ARRQQLVEKEVKMREKQFSQAR 1173
++ EKEV M++ + ++A+
Sbjct: 1217 KLHSEIKEKEVGMKKHEENEAK 1238
Score = 52.8 bits (125), Expect = 2e-06
Identities = 103/500 (20%), Positives = 213/500 (42%), Gaps = 69/500 (13%)
Query: 546 SLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSIT--------EISDNEDDL--LEYHRR 595
S A Q +Q L + + ++ N IT ++ D ++ LE H +
Sbjct: 653 SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 596 QRQERLR--EQEMERLERQRLETILNLCAEYSRADGGPEAG--ELPSIGEATAALALAGR 651
+ +E+ EQ+ E LE Q I L A+ E +L + L L
Sbjct: 713 EYKEKYLSLEQKTEELEGQ----IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRAT 768
Query: 652 RPSRGL------AGASGRSSEEPGVATQRLWESMERSDEEN--LKEECSS-TESTQQEHE 702
S+ L ++ ++ A + + + + + +EE LK++ + ++ T+ +HE
Sbjct: 769 ELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHE 828
Query: 703 DAPSTKLQGEVLALEE---ERAQVLGHVEQLKVRVKELEQQLQESAREAEMER-----AL 754
+ + ++Q V L++ E+ ++ + +K ++ ++ L+ S E E E A+
Sbjct: 829 EL-NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 755 LQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLE 814
L E+ + Q + + + L+E+ L+ ++KE++ + + E L Q
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQK-ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946
Query: 815 RESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESE---RLAR 871
+ +EE++L G + EL +S ++K+++ L G+++ +Q++E +L +
Sbjct: 947 LKQNEKEEQQLQG-----NINELKQSSEQKKKQIEALQ---GELKIAVLQKTELENKLQQ 998
Query: 872 DKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTRS 931
+ Q L EKEK++VL+ Y K+ T K++ S S
Sbjct: 999 QLTQAAQELAAEKEKISVLQNNYE---------KSQETFKQL---------QSDFYGRES 1040
Query: 932 GPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQ 991
L + S +LS+A S ++ + QN + ATL+ K++ LQ
Sbjct: 1041 ELLATRQDLKSVEEKLSLAQEDLI-SNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
Query: 992 QKGQQVIEEQRRRLAELKQK 1011
++ + + + Q+ + LK+K
Sbjct: 1100 ERCKALQDIQKEK--SLKEK 1117
Score = 52.4 bits (124), Expect = 3e-06
Identities = 75/335 (22%), Positives = 143/335 (42%), Gaps = 28/335 (8%)
Query: 685 ENLKEECSSTESTQQEHEDAPST--KLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQ 742
+ L E Q +E + T +LQ + E E ++ ++ ++ ++ L
Sbjct: 1005 QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLI 1064
Query: 743 ESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERD-KEAEALETE 801
+ + + L+Q + A+ L Q K QLQE+ AL+ IQKE+ KE E + +
Sbjct: 1065 SNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ-DIQKEKSLKEKELVNEK 1123
Query: 802 TKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQ 861
+KL E E + R E+E + L K E ++ I K+ +L Q +++ +
Sbjct: 1124 SKLAEIEEI-----KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGK 1178
Query: 862 AVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEV---YRSKM 918
A + ++K L + K++ L++ + K S +KE +
Sbjct: 1179 ADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEA-----KLHSEIKEKEVGMKKHE 1233
Query: 919 DGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAAT 978
+ EA + T + SSQ V+ L + T + G + L AT
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ--------TDDLRGEI-AVLEAT 1284
Query: 979 LQDIETKRQLALQQ--KGQQVIEEQRRRLAELKQK 1011
+Q+ + +R+ L++ KG+ IE+ + ++ EL++K
Sbjct: 1285 VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK 1319
Score = 45.8 bits (107), Expect = 3e-04
Identities = 107/528 (20%), Positives = 206/528 (39%), Gaps = 53/528 (10%)
Query: 684 EENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQE 743
+ +LKEE +E ++E E K QG L+++ A+ G V ++ LEQQL+E
Sbjct: 96 QASLKEEKWYSEELKKELE-----KYQG----LQQQEAKPDGLVTDSSAELQSLEQQLEE 146
Query: 744 SAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETK 803
+ E ++ E + A L E + ++ +L +++ + E L E
Sbjct: 147 AQTE-NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEAT 205
Query: 804 LFEDLEFQQLER---ESRVEEERELAGQGLLRSK--AELLRSIAKRKERLAILDSQAGQI 858
+ +DL+ + L+R E ++EL L E R K K+ L SQ
Sbjct: 206 VIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASS 265
Query: 859 RAQAVQESERLAR---DKNASLQLLQKEKEKLTVLERRYHSLTGG-----RPFPKTTSTL 910
A Q LA+ + +Q LQK K + L ++ +LT + + K
Sbjct: 266 EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325
Query: 911 KEVYRSKMDGEATSPLPRTRSGPLPSS-SGSSSSSSQLSVATLGRSPSPKSALLTQNGTG 969
E SK + +AT L S S S +S ++ V + + + +
Sbjct: 326 NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE 385
Query: 970 SLPRNLAATLQDIETKRQ------LALQQKGQQV---IEEQRRRLAE----LKQKAAAEA 1016
+ ++L A + ++ +R+ L LQ + Q+ + E R+L E LK++ +
Sbjct: 386 TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS 445
Query: 1017 QCQWDALHGAAPFPAGPSGFPPLMHHSIL------HHLPAGRERGEEGEHAYDTLSL--- 1067
+ D A S + + H L +++ +E + + +
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505
Query: 1068 ESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHA-------EKNRLME 1120
E+ + +E + G+ N+ + I +EK ++ +A E L +
Sbjct: 506 EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
Query: 1121 SREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQ 1168
+E+ L+ Q + + + Q E Q++ Q+ E++ +R Q
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQ 613
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 71.6 bits (174), Expect = 5e-12
Identities = 90/358 (25%), Positives = 127/358 (35%), Gaps = 39/358 (10%)
Query: 146 PAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLV 205
P+ AP PP + P+ L H T + + L + K +
Sbjct: 1097 PSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATP 1156
Query: 206 LEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSY-ENTSPAFSPLSSPASS 264
G P +P +P A +PP+ G ++ S T+PA +P P+
Sbjct: 1157 PSPKGGLATPPPKGAPTTPAA-------TPPSPKGGLATPSPKGAPTTPAATP---PSPK 1206
Query: 265 GSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPS 324
G A+ SP G P+ P P LA P+ P+ + P S KGG PP
Sbjct: 1207 GGLATPSPKGAPTTPAATPPSPKGG----LATPSPKGAPTTPAATPP--SPKGGPATPPP 1260
Query: 325 PGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVAISLSEY------PASGALSQPTSI 378
G PAAT + P G P V S P GA + P +
Sbjct: 1261 KGA----PTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAAT 1316
Query: 379 PGSPKFQPPVPAPRNKIGTLQDRPPSPFREP------PGSERVLTTSPSRQLVGRTFSDG 432
P SPK P P P+ PPSP P P S+ TT S++ G T
Sbjct: 1317 PPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKE--GPTPPAA 1374
Query: 433 LATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESP 490
+ P +P +RG +P + A+ PL + P + RE A +P
Sbjct: 1375 TPSHKGGPAMTPPSPKRG----PAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATP 1428
Score = 61.6 bits (148), Expect = 5e-09
Identities = 115/458 (25%), Positives = 162/458 (35%), Gaps = 84/458 (18%)
Query: 145 IPAGGRAPGPPYSPVPAESESLVNGNHTPQTA--TRGPSACA---SHSSLVSSIEKDLQE 199
IP +P P + P ++ + +HT A P C S +S +S + L
Sbjct: 730 IPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTY 789
Query: 200 IMDS------LVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSY--ENT 251
+ DS V + K + P +P+ N LS P SP V +S+ EN+
Sbjct: 790 LADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGN-----LSSPVSP----VEASFLPENS 840
Query: 252 SPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPA----------RSSSYHLALQ---- 297
SPA++ S SP G +V PL P S +L
Sbjct: 841 LSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGP 900
Query: 298 ----PPQSRPSGARSESPRLSRKGGHER--PPSPGLRGLLTDSPAATVLAEARRATESPR 351
P Q+ S SP+ +R + P SP +G T A + AT SP+
Sbjct: 901 ATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPK 960
Query: 352 LGGQLPVVAI-SLSEYPAS----GALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPF 406
P S PA+ GA + P + P SPK P P+P+ P P
Sbjct: 961 WAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKG-------APTPPA 1013
Query: 407 REPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSR 466
PP SP F G +T P SP +G + LP +P+
Sbjct: 1014 VTPP--------SPKGSPAATPFPKGASTPPAATPPSP----KGSPAATPLPKGAPT--- 1058
Query: 467 RALSPLPTRTTPDPK---LNREVAESPRPRRWAAHGASPEDFSLTLGARGR----RTRSP 519
P T P PK + +P P AA SP+ T +G P
Sbjct: 1059 -----TPAATLPSPKGGPATPSLKGAPTPP--AATPPSPKGGPATPSPKGAPMPPAATPP 1111
Query: 520 SPTLGESLAPHKGS-FSGRLSPAYSLGSLTGASPCQSP 556
SP G + PHKG+ + +P G L P +P
Sbjct: 1112 SPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAP 1149
Score = 58.5 bits (140), Expect = 4e-08
Identities = 80/338 (23%), Positives = 113/338 (33%), Gaps = 51/338 (15%)
Query: 209 PGAAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSP-------LSSP 261
P P A +P SP +P + G + S T PA +P ++ P
Sbjct: 1328 PPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPP 1387
Query: 262 ASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLA-----------LQPPQSRPSGARSES 310
+ A SP G P+V PL P ++ + + L PP P +
Sbjct: 1388 SPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAP 1447
Query: 311 PRLSRKGGHERPPSPG---LRGLLTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYP 367
+ KGG P S G L + SP + + SP+ P
Sbjct: 1448 ATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPA--------- 1498
Query: 368 ASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGR 427
GA + P IP SPK P P+ R P +P + T +P L+
Sbjct: 1499 PMGAPTLPAVIPSSPKEVPATPSSRRD-------PIAPTATLLSKKTPATLAPKEALIPP 1551
Query: 428 TFSDGLATRTLQPPESPRLGRRGLDSMRELPP-LSPSLSRRALSPL-----PTRTTPDPK 481
+ +T P PP ++PS + A SP P T+P PK
Sbjct: 1552 AMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPK 1611
Query: 482 LNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSP 519
E+P P A SPE T +G T P
Sbjct: 1612 ------EAPTPP--AVTPPSPEKGPATPAPKGTPTSPP 1641
Score = 43.9 bits (102), Expect = 0.001
Identities = 67/271 (24%), Positives = 95/271 (35%), Gaps = 42/271 (15%)
Query: 146 PAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLV 205
PA G P SP P SL + +P + T A +S +K + + LV
Sbjct: 1628 PATPAPKGTPTSP-PVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLV 1686
Query: 206 LEEPGAAGKKPAATSPL--SPMANGGRYLLSPPTSPGAMSV-GSSYENTSPAFSPL---- 258
P + P T+P P SPP P + GS ++ A +PL
Sbjct: 1687 APAPEST---PIITAPTRKGPQTKKSS-ATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQ 1742
Query: 259 --SSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRK 316
SS + G ASHSP G P P ++++ L P+S A
Sbjct: 1743 KDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSA---------- 1792
Query: 317 GGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPT 376
PSP + L SP T+ + + SP L + P ++ ++ L P
Sbjct: 1793 -----APSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPE 1847
Query: 377 SIPGSPKFQP-------------PVPAPRNK 394
I G FQ PVP P K
Sbjct: 1848 PISGGVPFQSVLVNMPTPKSAGIPVPTPSAK 1878
Score = 38.5 bits (88), Expect = 0.043
Identities = 148/664 (22%), Positives = 240/664 (36%), Gaps = 142/664 (21%)
Query: 127 STFLRFNHPAEAKWMKSMIPAGGRAPGPPYSP-VPAESESLVNGNHTPQTATRGPSACAS 185
+T L PA +++IP P P +P +P E+ AT +S
Sbjct: 1531 ATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEA---------PATPSSKEASS 1581
Query: 186 HSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVG 245
++ S K + L+ PA TSP SP +P
Sbjct: 1582 PPAVTPSTYKGAPSPKELLI---------PPAVTSP------------SPKEAP------ 1614
Query: 246 SSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSG 305
T PA +P P+ A+ +P G P+ PP+ P SS + P S
Sbjct: 1615 -----TPPAVTP---PSPEKGPATPAPKGT---PTSPPVTP---SSLKDSPTSPASVTCK 1660
Query: 306 ARSESPRLSRKGGHERPPSPGLRGLLTDSPAAT--VLAEARRATESPRLGGQLPVVAISL 363
+ P+ S+ ++ P+ L+ +P +T + A R+ ++ + P +
Sbjct: 1661 MGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDP 1720
Query: 364 SEYPAS-GALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSPSR 422
S S G LS T P P +P ++ T + + S P G + S
Sbjct: 1721 SAKNGSKGPLS--TVAPA-----PLLPVQKDSSKTAKGKDAS--HSPKGPLAPPESKAST 1771
Query: 423 QLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDPKL 482
L F + L PES + S PP+S L A SP+PT P
Sbjct: 1772 PLTAAAFE-----KVLPKPESASV------SAAPSPPVSLPL---APSPVPTL----PPK 1813
Query: 483 NREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSPAY 542
+ + SP G SPS + LAP + L P
Sbjct: 1814 QQFLPSSP----------------------GLVLESPS----KPLAP---ADEDELLPLI 1844
Query: 543 SLGSLTGASPCQSPCVQR--------KLSSGDLRVPVTRERKNSITEISDNEDDLLEYHR 594
++G P QS V + + + PVT+ K S TE SD+++ + E
Sbjct: 1845 PPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTE-SDSDESVPE--- 1900
Query: 595 RQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPS 654
L EQ+ + Q+ + L AE + +A + S +A A++ G R
Sbjct: 1901 ------LEEQDSTQATTQQAQ--LAAAAEIDE-EPVSKAKQSRSEKKARKAMSKLGLRQV 1951
Query: 655 RGLAGASGRSSEE-PGVATQRLWESMERSDEENLKEECSSTESTQQ-EHEDAPSTKLQGE 712
G+ + R S+ V T+ SD + E + +QQ + A K+QGE
Sbjct: 1952 TGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGE 2011
Query: 713 VLALEEERAQV--------LGHVEQLKVRVKELEQQL-QESAREAEMERALLQGEREAER 763
++ +E Q V++ V VK++E + Q + A+ RAL +
Sbjct: 2012 AVSNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVN 2071
Query: 764 ALLQ 767
A+++
Sbjct: 2072 AIME 2075
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 70.9 bits (172), Expect = 8e-12
Identities = 83/333 (24%), Positives = 148/333 (44%), Gaps = 29/333 (8%)
Query: 641 EATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE--------CS 692
E TAA+ +A R A G++S + +R + +R KEE
Sbjct: 302 EWTAAIQMAIRLQ------AEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQE 355
Query: 693 STESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMER 752
E QE E + Q E L EEE E+ + + +EL+Q L+ REAE R
Sbjct: 356 EKERKLQELELLQEAQRQAERLLQEEE--------ERRRSQHRELQQALEGQLREAEQAR 407
Query: 753 ALLQGE---REAERALLQKEQKAVDQLQEKL-VALETGIQKERDKEAEALETETKLFEDL 808
A +Q E +E E A ++ K ++++Q++L AL+ ++ RD+E+ + +T+L E+
Sbjct: 408 ASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRI-AQTRLLEE- 465
Query: 809 EFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESER 868
E ++L++ +++EE+E + + K EL + +A++ L Q ++R + E
Sbjct: 466 EEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADED 525
Query: 869 LARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPR 928
+ + Q K + R H + G P T+S+ + +S
Sbjct: 526 VEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKRL 585
Query: 929 TRSGPLPSSSGSSSSSSQLSVATLG-RSPSPKS 960
TR G + + S +S+ Q G +P+P S
Sbjct: 586 TRWGSQGNRTPSPNSNEQQKSLNGGDEAPAPAS 618
Score = 39.7 bits (91), Expect = 0.019
Identities = 52/241 (21%), Positives = 100/241 (41%), Gaps = 33/241 (13%)
Query: 566 DLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYS 625
DL+ +R+ + E++LL + Q ++ + QE+E L+ + + L E
Sbjct: 324 DLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEE 383
Query: 626 RADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEE 685
R R R L A E A + ME +EE
Sbjct: 384 RR-----------------------RSQHRELQQALEGQLREAEQARASMQAEMELKEEE 420
Query: 686 --NLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQ- 742
++ E QQ ++A LQ EV A +E + + L+ ++L+Q +Q
Sbjct: 421 AARQRQRIKELEEMQQRLQEA----LQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQL 476
Query: 743 ESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETET 802
+ +E +ERA Q E+E + + ++ +++ Q Q++L + Q+ D++ EA + +
Sbjct: 477 KEEQERYIERA--QQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQR-ADEDVEAAQRKL 533
Query: 803 K 803
+
Sbjct: 534 R 534
Score = 37.4 bits (85), Expect = 0.096
Identities = 26/91 (28%), Positives = 43/91 (47%), Gaps = 7/91 (7%)
Query: 1101 IEEMEKMLKEAHAEKNRLMESREREMELRRQAL-------EEERRRREQVERRLQSESAR 1153
++E E+ + H E + +E + RE E R ++ EEE R+ Q + L+ R
Sbjct: 378 LQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQR 437
Query: 1154 RQQLVEKEVKMREKQFSQARPLTRYLPIRKE 1184
Q+ ++ EVK R + S TR L +E
Sbjct: 438 LQEALQLEVKARRDEESVRIAQTRLLEEEEE 468
Score = 35.8 bits (81), Expect = 0.28
Identities = 31/98 (31%), Positives = 41/98 (41%), Gaps = 13/98 (13%)
Query: 1213 RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLK-GVIYFQA--IEEVYYDHLR 1269
+GYL K G ++W +RWF +L+ + Y E K K G+I A EV D
Sbjct: 220 QGYLWKRGHLRRNWAERWF---QLQPSCLCYFGSEECKEKRGIIPLDAHCCVEVLPDR-- 274
Query: 1270 SAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1307
FCVKT +R Y M A + W I
Sbjct: 275 -----DGKRCMFCVKTANRTYEMSASDTRQRQEWTAAI 307
Score = 35.4 bits (80), Expect = 0.36
Identities = 26/86 (30%), Positives = 45/86 (52%), Gaps = 11/86 (12%)
Query: 1100 KIEEMEKMLKEAHAEKNRLMESREREMELR----RQALEEERRRRE------QVERRLQS 1149
K++E+E +L+EA + RL++ E + +QALE + R E Q E L+
Sbjct: 360 KLQELE-LLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKE 418
Query: 1150 ESARRQQLVEKEVKMREKQFSQARPL 1175
E A RQ+ KE++ +++ +A L
Sbjct: 419 EEAARQRQRIKELEEMQQRLQEALQL 444
Score = 35.0 bits (79), Expect = 0.48
Identities = 40/194 (20%), Positives = 80/194 (41%), Gaps = 18/194 (9%)
Query: 979 LQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPP 1038
LQ++E ++ Q + EE+RRR + + A E Q L A A
Sbjct: 361 LQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQ-----LREAEQARASMQAEME 415
Query: 1039 LMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDM 1098
L +E E + + L LE + +++ A +
Sbjct: 416 LKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRD------------EESVRIAQTRLL 463
Query: 1099 GKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLV 1158
+ EE K L + E+ R +E ++E E +Q + ++ R +Q +++L+ E + +Q
Sbjct: 464 EEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLE-EVRQNRQRA 522
Query: 1159 EKEVKMREKQFSQA 1172
+++V+ +++ QA
Sbjct: 523 DEDVEAAQRKLRQA 536
Score = 32.0 bits (71), Expect = 4.0
Identities = 28/78 (35%), Positives = 35/78 (44%), Gaps = 14/78 (17%)
Query: 1102 EEMEKMLKEAHAEKNRLMESREREMELRRQA----LEEERRRREQVERRLQ--------- 1148
EE L++ EK R ++ E E +RQA EEE RRR Q R LQ
Sbjct: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQ-HRELQQALEGQLRE 402
Query: 1149 SESARRQQLVEKEVKMRE 1166
+E AR E E+K E
Sbjct: 403 AEQARASMQAEMELKEEE 420
Score = 30.8 bits (68), Expect = 9.0
Identities = 15/67 (22%), Positives = 39/67 (58%), Gaps = 1/67 (1%)
Query: 1102 EEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKE 1161
+++++ +E ++ R ++E E+ +Q EE+ R+ +++E LQ + ++L+++E
Sbjct: 323 KDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELE-LLQEAQRQAERLLQEE 381
Query: 1162 VKMREKQ 1168
+ R Q
Sbjct: 382 EERRRSQ 388
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,305,612
Number of Sequences: 37866
Number of extensions: 3350523
Number of successful extensions: 37529
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 439
Number of HSP's successfully gapped in prelim test: 2173
Number of HSP's that attempted gapping in prelim test: 18214
Number of HSP's gapped (non-prelim): 14760
length of query: 1319
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1205
effective length of database: 13,930,794
effective search space: 16786606770
effective search space used: 16786606770
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.