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Search of human proteins with 221219020
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221219020 NYD-SP11 protein [Homo sapiens]
(2873 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221219020 NYD-SP11 protein [Homo sapiens] 5705 0.0
gi|148746195 trichohyalin [Homo sapiens] 264 1e-69
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 244 1e-63
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 215 6e-55
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 200 1e-50
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 193 2e-48
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 189 4e-47
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 189 4e-47
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 189 4e-47
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 189 4e-47
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 189 4e-47
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 189 4e-47
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 189 4e-47
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 189 4e-47
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 183 2e-45
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 176 2e-43
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 174 9e-43
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 174 9e-43
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 174 9e-43
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 174 9e-43
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 171 7e-42
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 167 1e-40
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 167 1e-40
gi|71061468 centromere protein E [Homo sapiens] 166 3e-40
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 165 5e-40
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 162 4e-39
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 149 3e-35
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 148 7e-35
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 148 7e-35
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 147 1e-34
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 5705 bits (14801), Expect = 0.0
Identities = 2873/2873 (100%), Positives = 2873/2873 (100%)
Query: 1 MSSPRLIPLWKDLKLLLNDTINKSKQPSEDPKNCLIVLSDRSQAVAWMKSKTEDMVEKRT 60
MSSPRLIPLWKDLKLLLNDTINKSKQPSEDPKNCLIVLSDRSQAVAWMKSKTEDMVEKRT
Sbjct: 1 MSSPRLIPLWKDLKLLLNDTINKSKQPSEDPKNCLIVLSDRSQAVAWMKSKTEDMVEKRT 60
Query: 61 FSMTERLPPIQSMVHAGSFHILVVYCGDLILRLFGDHFRAFKPLGKVPCRFNISCLCYDP 120
FSMTERLPPIQSMVHAGSFHILVVYCGDLILRLFGDHFRAFKPLGKVPCRFNISCLCYDP
Sbjct: 61 FSMTERLPPIQSMVHAGSFHILVVYCGDLILRLFGDHFRAFKPLGKVPCRFNISCLCYDP 120
Query: 121 EMKMLLSGILGAVVTWVIELGGTGLQIAHMVSMPGDELVQDIVLNGPSGSLLALCETVVR 180
EMKMLLSGILGAVVTWVIELGGTGLQIAHMVSMPGDELVQDIVLNGPSGSLLALCETVVR
Sbjct: 121 EMKMLLSGILGAVVTWVIELGGTGLQIAHMVSMPGDELVQDIVLNGPSGSLLALCETVVR 180
Query: 181 VLMHQGKGQLGEVKRFTSTSSGSSITCCFTCFDQGFLYAGNQAGEIQVWSLQQGHPLHSF 240
VLMHQGKGQLGEVKRFTSTSSGSSITCCFTCFDQGFLYAGNQAGEIQVWSLQQGHPLHSF
Sbjct: 181 VLMHQGKGQLGEVKRFTSTSSGSSITCCFTCFDQGFLYAGNQAGEIQVWSLQQGHPLHSF 240
Query: 241 QAHQSGVICIRSRPEAHTLLTAGSDSLIKEWNLTSGSLLRRLELGEELYRLQFIDSITFF 300
QAHQSGVICIRSRPEAHTLLTAGSDSLIKEWNLTSGSLLRRLELGEELYRLQFIDSITFF
Sbjct: 241 QAHQSGVICIRSRPEAHTLLTAGSDSLIKEWNLTSGSLLRRLELGEELYRLQFIDSITFF 300
Query: 301 CQTAHSFSLHRLPCFYSLFNVCGSAPQQLRRVCCGNNWFRILCTTEDGLLRFVSPVTGDL 360
CQTAHSFSLHRLPCFYSLFNVCGSAPQQLRRVCCGNNWFRILCTTEDGLLRFVSPVTGDL
Sbjct: 301 CQTAHSFSLHRLPCFYSLFNVCGSAPQQLRRVCCGNNWFRILCTTEDGLLRFVSPVTGDL 360
Query: 361 LVITWPFSILDQAVDWAYDPGKEELFVATGSSEVLVFDTTRCPCPAKYLLGTSPNSQDFV 420
LVITWPFSILDQAVDWAYDPGKEELFVATGSSEVLVFDTTRCPCPAKYLLGTSPNSQDFV
Sbjct: 361 LVITWPFSILDQAVDWAYDPGKEELFVATGSSEVLVFDTTRCPCPAKYLLGTSPNSQDFV 420
Query: 421 QCLAYGHFNLGRGLEGLIFSGHQSGVIRVLSQHSCARLEKFMHFGAVLALSTLSGGIFGG 480
QCLAYGHFNLGRGLEGLIFSGHQSGVIRVLSQHSCARLEKFMHFGAVLALSTLSGGIFGG
Sbjct: 421 QCLAYGHFNLGRGLEGLIFSGHQSGVIRVLSQHSCARLEKFMHFGAVLALSTLSGGIFGG 480
Query: 481 QGNSLLCSYGMDDYVHLSEAVLDGVKVQLRPLASILSSCHLTHLILLPKSVGAITETNCL 540
QGNSLLCSYGMDDYVHLSEAVLDGVKVQLRPLASILSSCHLTHLILLPKSVGAITETNCL
Sbjct: 481 QGNSLLCSYGMDDYVHLSEAVLDGVKVQLRPLASILSSCHLTHLILLPKSVGAITETNCL 540
Query: 541 RLWKFHDFLSSGSQNGLKFIETLPLHLCAITSFDVCLSLSLFVTGSADGSVRIWDFHGRL 600
RLWKFHDFLSSGSQNGLKFIETLPLHLCAITSFDVCLSLSLFVTGSADGSVRIWDFHGRL
Sbjct: 541 RLWKFHDFLSSGSQNGLKFIETLPLHLCAITSFDVCLSLSLFVTGSADGSVRIWDFHGRL 600
Query: 601 IGILDSSLHFGPVCFANDRGDLLVTFNQSLYLVSCLKLLPPALLTRLSFMSISDEVLEVP 660
IGILDSSLHFGPVCFANDRGDLLVTFNQSLYLVSCLKLLPPALLTRLSFMSISDEVLEVP
Sbjct: 601 IGILDSSLHFGPVCFANDRGDLLVTFNQSLYLVSCLKLLPPALLTRLSFMSISDEVLEVP 660
Query: 661 KPFIPSFFFSFETMFVPKYIYPGQAQQKLVGLEKLVNNRAIAFDHSVPHVIEEDEEGSPV 720
KPFIPSFFFSFETMFVPKYIYPGQAQQKLVGLEKLVNNRAIAFDHSVPHVIEEDEEGSPV
Sbjct: 661 KPFIPSFFFSFETMFVPKYIYPGQAQQKLVGLEKLVNNRAIAFDHSVPHVIEEDEEGSPV 720
Query: 721 LLRSSMHYSLQDMEDWMQVSKRYQCHYVLPPQLQLTSWDGLNPYQILRYYFGHGREWLFA 780
LLRSSMHYSLQDMEDWMQVSKRYQCHYVLPPQLQLTSWDGLNPYQILRYYFGHGREWLFA
Sbjct: 721 LLRSSMHYSLQDMEDWMQVSKRYQCHYVLPPQLQLTSWDGLNPYQILRYYFGHGREWLFA 780
Query: 781 PDCYIPNSVIRARLWPEGTPIYLQCNLHAPQRELEWDRSQEFFFWHSRVRAISNTEYPKN 840
PDCYIPNSVIRARLWPEGTPIYLQCNLHAPQRELEWDRSQEFFFWHSRVRAISNTEYPKN
Sbjct: 781 PDCYIPNSVIRARLWPEGTPIYLQCNLHAPQRELEWDRSQEFFFWHSRVRAISNTEYPKN 840
Query: 841 KEEDEHFLEMRLSKDVTYSVLTDGANRSWLGRKMSEITINSMIETMLNIMVHASLLKYQC 900
KEEDEHFLEMRLSKDVTYSVLTDGANRSWLGRKMSEITINSMIETMLNIMVHASLLKYQC
Sbjct: 841 KEEDEHFLEMRLSKDVTYSVLTDGANRSWLGRKMSEITINSMIETMLNIMVHASLLKYQC 900
Query: 901 CVGALGQIFASYQVSPALRSETARRLLNDTTNSNPLIRELAWEGLKRLGMITHLFAMPLA 960
CVGALGQIFASYQVSPALRSETARRLLNDTTNSNPLIRELAWEGLKRLGMITHLFAMPLA
Sbjct: 901 CVGALGQIFASYQVSPALRSETARRLLNDTTNSNPLIRELAWEGLKRLGMITHLFAMPLA 960
Query: 961 QGLMDKDERVRIKTLSLMAEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRA 1020
QGLMDKDERVRIKTLSLMAEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRA
Sbjct: 961 QGLMDKDERVRIKTLSLMAEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRA 1020
Query: 1021 TDLQILSTQVEQRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSK 1080
TDLQILSTQVEQRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSK
Sbjct: 1021 TDLQILSTQVEQRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSK 1080
Query: 1081 GQRRGQAGVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQW 1140
GQRRGQAGVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQW
Sbjct: 1081 GQRRGQAGVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQW 1140
Query: 1141 SSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAK 1200
SSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAK
Sbjct: 1141 SSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAK 1200
Query: 1201 VINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTK 1260
VINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTK
Sbjct: 1201 VINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTK 1260
Query: 1261 MSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQ 1320
MSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQ
Sbjct: 1261 MSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQ 1320
Query: 1321 EGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGN 1380
EGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGN
Sbjct: 1321 EGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGN 1380
Query: 1381 VTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEK 1440
VTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEK
Sbjct: 1381 VTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEK 1440
Query: 1441 VVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG 1500
VVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG
Sbjct: 1441 VVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG 1500
Query: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQ 1560
EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQ
Sbjct: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQ 1560
Query: 1561 VTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAY 1620
VTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAY
Sbjct: 1561 VTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAY 1620
Query: 1621 VKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
VKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA
Sbjct: 1621 VKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
Query: 1681 KKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEG 1740
KKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEG
Sbjct: 1681 KKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEG 1740
Query: 1741 KLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGR 1800
KLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGR
Sbjct: 1741 KLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGR 1800
Query: 1801 KREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENL 1860
KREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENL
Sbjct: 1801 KREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENL 1860
Query: 1861 LYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVE 1920
LYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVE
Sbjct: 1861 LYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVE 1920
Query: 1921 DSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEG 1980
DSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEG
Sbjct: 1921 DSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEG 1980
Query: 1981 KETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR 2040
KETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR
Sbjct: 1981 KETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR 2040
Query: 2041 GQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKM 2100
GQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKM
Sbjct: 2041 GQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKM 2100
Query: 2101 KRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM 2160
KRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM
Sbjct: 2101 KRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM 2160
Query: 2161 TEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEV 2220
TEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEV
Sbjct: 2161 TEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEV 2220
Query: 2221 ESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQV 2280
ESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQV
Sbjct: 2221 ESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQV 2280
Query: 2281 EKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDRE 2340
EKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDRE
Sbjct: 2281 EKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDRE 2340
Query: 2341 KEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
KEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEM
Sbjct: 2341 KEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
Query: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKEREVMGKYEPIPPHVLGTVLESQAQ 2460
KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKEREVMGKYEPIPPHVLGTVLESQAQ
Sbjct: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKEREVMGKYEPIPPHVLGTVLESQAQ 2460
Query: 2461 DLKTPFMSHILRRTVEAEELQHKPLGAWWKWFLQHPPLMGQTEVQLPLSQIPAKEQHADV 2520
DLKTPFMSHILRRTVEAEELQHKPLGAWWKWFLQHPPLMGQTEVQLPLSQIPAKEQHADV
Sbjct: 2461 DLKTPFMSHILRRTVEAEELQHKPLGAWWKWFLQHPPLMGQTEVQLPLSQIPAKEQHADV 2520
Query: 2521 SLSDVEWIRHVLERMEAGEQLSRDGFHRLCQLLKDLASKGNLEWLHLAKHEAIVYRHRQA 2580
SLSDVEWIRHVLERMEAGEQLSRDGFHRLCQLLKDLASKGNLEWLHLAKHEAIVYRHRQA
Sbjct: 2521 SLSDVEWIRHVLERMEAGEQLSRDGFHRLCQLLKDLASKGNLEWLHLAKHEAIVYRHRQA 2580
Query: 2581 LESQDTRISSRQSMSPKYLKVIPPIKAKEKESWPKPLAVPTQKSPLATKRIPDPRAKNWH 2640
LESQDTRISSRQSMSPKYLKVIPPIKAKEKESWPKPLAVPTQKSPLATKRIPDPRAKNWH
Sbjct: 2581 LESQDTRISSRQSMSPKYLKVIPPIKAKEKESWPKPLAVPTQKSPLATKRIPDPRAKNWH 2640
Query: 2641 LLGEPYRSERAQQISIAHKEMEMQYFYPATRDIFPSAHASVEKQTLALMFQKDFWDFKDK 2700
LLGEPYRSERAQQISIAHKEMEMQYFYPATRDIFPSAHASVEKQTLALMFQKDFWDFKDK
Sbjct: 2641 LLGEPYRSERAQQISIAHKEMEMQYFYPATRDIFPSAHASVEKQTLALMFQKDFWDFKDK 2700
Query: 2701 RRFPKLPKLEKKTQPISKKKEELPLWETFVALYHVLRMLQQRYPKDSTAWMEQFYQLMDL 2760
RRFPKLPKLEKKTQPISKKKEELPLWETFVALYHVLRMLQQRYPKDSTAWMEQFYQLMDL
Sbjct: 2701 RRFPKLPKLEKKTQPISKKKEELPLWETFVALYHVLRMLQQRYPKDSTAWMEQFYQLMDL 2760
Query: 2761 YQLKSPRIQKLLQELLMREEPQPQEIIYEEALKATELVPGERLFCCLFCGSSHTPRSPQE 2820
YQLKSPRIQKLLQELLMREEPQPQEIIYEEALKATELVPGERLFCCLFCGSSHTPRSPQE
Sbjct: 2761 YQLKSPRIQKLLQELLMREEPQPQEIIYEEALKATELVPGERLFCCLFCGSSHTPRSPQE 2820
Query: 2821 FQGAVPLPWQNCVRTILPVGIARYGILELAWKSLPEADLHLTKALTHTVAPTL 2873
FQGAVPLPWQNCVRTILPVGIARYGILELAWKSLPEADLHLTKALTHTVAPTL
Sbjct: 2821 FQGAVPLPWQNCVRTILPVGIARYGILELAWKSLPEADLHLTKALTHTVAPTL 2873
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 264 bits (674), Expect = 1e-69
Identities = 347/1509 (22%), Positives = 684/1509 (45%), Gaps = 211/1509 (13%)
Query: 991 QLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLN----ENLTLSHRDEK 1046
QL ++Q+ RE Q + EE + Q L + E+R + E T H E+
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 1047 PAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKTKER 1106
L E + E E + + RR Q ++ Q+ R ++ +ER
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE--ERREQRLKR--QEEEER 527
Query: 1107 DSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIA 1166
+++ +E L ++ ++ EE Q +L ++ + + + K
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ---RLKREQEERRDQLLKREEE 584
Query: 1167 LTLKRLQKIRDKR-DKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRG 1225
+RL++ +++R +++ +++++ +++ +E ++ EE +Q + + + + R
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644
Query: 1226 ASGISGRRSTAGDGSSWRDDLCRL-MALRISGSQTKMSENLNAELVTFAQEMLVDRHPSW 1284
++ ++ RL L+ + + + L E A+E + R P W
Sbjct: 645 QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704
Query: 1285 ELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIR----EDMIQGVTQEVIRHK 1340
+ +Q ++SKV P K QEG R E+ + E+ +
Sbjct: 705 Q-WQLESEADARQSKVYSR--------PRK-----QEGQRRRQEQEEKRRRRESELQWQE 750
Query: 1341 EVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPG------NVTMGKEISKKEEKK 1394
E ++Q +++ RD + + ++G++ + P +E ++E++
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF 810
Query: 1395 TFQKSPKQGRKAVQKERK--VGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIE 1452
++ K+ R+ ++ER+ + ++ E + R+ +++++E EE ++++ + +
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE----EEDGLQEDQERRRSQ 866
Query: 1453 RTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEW--EKRLLQEEEKLHQAGEKLSPEEEML 1510
Q W+ +E ++ T + A +E+ E++LLQEEE E+L EE
Sbjct: 867 EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE------EELQREER-- 918
Query: 1511 QEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQE 1570
+K+ + E+ +Q E +EQ ++EE++ EE R +E+E+Q ++++ Q+
Sbjct: 919 --EKRRRQEQERQYRE-------EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Query: 1571 EHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREM 1630
E + EK+R QE K +EEE+L QEE QL +EER + R
Sbjct: 970 EEQLLG-----EEPEKRRRQEREKKYREEEELQQEEEQLLREER-----------EKRRR 1013
Query: 1631 AQAEGKFAQKEETLAQRGEKLSQEAEKLA-QKRKKLAKKWEKVAREEEKLAKKGGKLAEV 1689
+ E ++ +K+E + + L +E EK Q+R++ ++ E++ +EEE+L G+ E
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL---GEERET 1070
Query: 1690 KNILAQKVEELPQREQNLDWQEKELAQELEELE--WDMEELSWKEEELNQEEGKLVEEKK 1747
+ Q++E ++E+ L +E++L +E E + E +EEEL QEE +L+ E++
Sbjct: 1071 RR--RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 1748 KLAEEEEALAWQREKLSEEETKLAQEEELLIQEK--EKLAQHKEKMPEEEERLGRKREQL 1805
+ +E E+ EE ++ QEEE L++E+ ++ Q E+ EEE L ++ EQL
Sbjct: 1129 EKRRRQEL-----ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183
Query: 1806 I-EKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNK 1864
+ E++ K Q+RER EEL + K + + E EK ++N +Y K
Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243
Query: 1865 ERLTHSKKQLVQVKNKLGMFNKILAQV-------------------------EEKLTQEK 1899
R +QL + + + L + EE+L +E+
Sbjct: 1244 GRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE 1303
Query: 1900 ETVIKKKEKLAETEKKLVQVE----------DSLAKKQEKLAQEKMKLALEKA------- 1942
+ K++++ ++ EK+L++ E D +++E+L QE+ + L +
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363
Query: 1943 ------MVQGKKRLRGELDIAKEEKALNL----EMKRLAEEKMRLVEGKETLSKGETPET 1992
QG+K L E + ++E+ + R E + +L + ++ + E +
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423
Query: 1993 SRQ---RKMTQVEQELF----ERKLSLEEKILLHEDRILAMEESEIAKGK----LEFTRG 2041
SRQ RK + EQ++ ERK EE+ L E EE ++ + + L
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 2042 QRIFVQGQRKLAKASR-KLIKKRESLSKEPAKLNKILKALQKLTRDER--KLTQEEIKMT 2098
R F++ +++L + R + +++E S+EP + K L+ Q+L R +R K QEE ++
Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQELRSQEPER--KFLEEEQQLHRQQRQRKFLQEEQQLR 1541
Query: 2099 KMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEE 2158
+ +R ++RR ++ + ++ + +L++ E+ RK R K+RR +E
Sbjct: 1542 RQERG---QQRRQDRDRKFREEEQLRQEREEQQLSRQERD--RKFRLEEQKVRRQ-EQER 1595
Query: 2159 KMTEEESKLARKHSEVILDDEEEGGIEEEEVI------PFLKRRWRKRKEAKRGDKPKEK 2212
K E+E +L R+ + L E + E+E + L R+ R RK + + + +
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 2213 FSSQVDEVESEEHFSEEMESLLDELEKQE--------SLSSEEEEEREEEEER----EEE 2260
Q + + F EE E LL E E+Q+ EE++ R +E ER EE+
Sbjct: 1656 EREQQLRHDRDRKFREE-EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714
Query: 2261 EVREEEEERK--EEE----EGEEKQVEKEE-------EEKKKKKKEKKKEEVQEKEEVFE 2307
++R +E ERK EEE E E++Q+ ++E EE+ + ++E+++ QE++ F
Sbjct: 1715 QLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFR 1774
Query: 2308 EKEEIMSEEETESLSDEE-----EEEESCSLEEE------VDREKEILKKEKQFKLQEQR 2356
E+E++ E E + L +E EEE E E R+ + +E+Q +L+EQ
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834
Query: 2357 RKSLRGRER 2365
++ + R+R
Sbjct: 1835 QRLRQERDR 1843
Score = 258 bits (660), Expect = 5e-68
Identities = 247/1082 (22%), Positives = 533/1082 (49%), Gaps = 132/1082 (12%)
Query: 1334 QEVIRHKEVMP-----REEEQAQKKAR-DMLGLEETQVILKKGKKVIFLEPGNVTMGKEI 1387
+E +R +E++ REE+Q Q++ R D + EE + +K + V+
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL------------- 253
Query: 1388 SKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGK 1447
+KEE+K ++ P++ R+ ++E ++ K++R+ + ER E+ ++ E+++ +++ +
Sbjct: 254 -RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312
Query: 1448 LVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEE 1507
ER ++ ++ + +Q + + +EE ++ L+ E++ + ++L E+
Sbjct: 313 ----ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368
Query: 1508 EMLQEDKKLKWEEWKQVWENMLSSKS--------------KEQQYKDEEEVTLEEEVSRE 1553
E + +++L+ E+ + + + + +EQQ + E+++ E+++ RE
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 1554 GEEKEQQVTEEQ--------RHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEE----- 1600
EE+ + EQ R +E W + + R E++R +++ K QEEE
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 1601 -KLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLA 1659
KL +EER+ QE R+ ++ ++ E + K ++EE L QR Q +
Sbjct: 489 LKLEEEERREQQERREQ-----QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE 543
Query: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
++R++L K+ E+ E+E+ ++ + E + K EE ++++ QE+ L Q L+
Sbjct: 544 ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603
Query: 1720 ELEWD-MEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLI 1778
E + +E+ +E+ L +EE + E +++L + EE ++++L E+ + ++
Sbjct: 604 REEVERLEQEERREQRLKREEPE-EERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 1779 QEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKR-----ERWINSME-ELTKNKMI 1832
+E+E+L Q ++ EEE R+ ++L E++ + A++R +W +E E +
Sbjct: 663 EEEERLEQRLKREHEEE----RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 1833 LYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVE 1892
+Y + + ++ +++EK +R+ L + +E H ++Q + + Q E
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW----QWQAE 774
Query: 1893 EKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRG 1952
EK + ++ + + L E ++ ++ E+ ++Q L +E+ K E+ Q ++R +
Sbjct: 775 EKSERGRQR-LSARPPLREQRERQLRAEERQQREQRFLPEEEEK---EQRRRQRREREK- 829
Query: 1953 ELDIAKEEKALNLEMK--RLAEEKMRLVEGKETLSKGETPETSRQRKMT-QVEQELFERK 2009
EL +EE+ L + +L EE+ L E +E + + E R +K Q+E+E R+
Sbjct: 830 ELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE---RRRSQEQRRDQKWRWQLEEERKRRR 886
Query: 2010 LSLEEKILLHED-----RILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRE 2064
+L K L E ++L EE E+ + + E R Q Q + + +L ++ E
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE-----QERQYREEEQLQQEEE 941
Query: 2065 SLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWD 2124
L +E + + + ++ R ++KL Q+E ++ + E+R E+ K +E +
Sbjct: 942 QLLREEREKRR-RQERERQYRKDKKLQQKEEQLLGEE-----PEKRRRQEREKKYREEEE 995
Query: 2125 FSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGI 2184
++ +L ++E++ R+Q + R K++++ +EE +L R+ E
Sbjct: 996 LQQEEEQLLREEREKRRRQ-----EWERQYRKKDELQQEEEQLLREERE----------- 1039
Query: 2185 EEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLS 2244
KRR ++R+ R + E+ + +++ EE + + L + K+E L
Sbjct: 1040 ---------KRRLQERERQYREE---EELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087
Query: 2245 SEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEE 2304
EEE+ EE E+ + RE + +EE + EE+Q+ +EE EK+++++ ++ + +E+EE
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER--QYREEEE 1145
Query: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRE 2364
V +E+E+++ EE + +E E EEE+ +E+E L +E+Q K +++R + R E
Sbjct: 1146 VQQEEEQLLREEPEKRR--RQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203
Query: 2365 RV 2366
+
Sbjct: 1204 EL 1205
Score = 256 bits (653), Expect = 3e-67
Identities = 326/1460 (22%), Positives = 657/1460 (45%), Gaps = 150/1460 (10%)
Query: 986 RTSLLQLTQKQETFREMQQQMIG---EEPLDHLLGMRATDLQI-LSTQVEQRLNENLTLS 1041
R LL+ +++ +E ++Q + EE D LL Q L + E+RL + L
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK-- 603
Query: 1042 HRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLK 1101
R+E + LK + P ++ + +RR Q ++ ++ + LK
Sbjct: 604 -REEVERLEQEERREQRLKR--EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 1102 KTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDS-QEKDI 1160
+ +E + + + E+ E A E E+A + +L + D+ Q K
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY 720
Query: 1161 SKDHIALTLKRLQKIRDKRDKKATA---QKLKKKHKKKGKEAKVINEETTPPVMEQPVTK 1217
S+ +R Q+ +KR ++ + Q+ ++ H+++ +E + + E+
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 1218 KVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQE-- 1275
+ ++ R R + R+ R + Q + + + F +E
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQ--RFLPEEEEKEQRRRQRREREKELQFLEEEE 838
Query: 1276 MLVDRHPSWELFQEICPLL----KKESKVLLEDLDWDVVPPEK----------KPIFIQE 1321
L R + +L +E L ++ S+ D W E+ KP ++
Sbjct: 839 QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ 898
Query: 1322 GAIREDMIQGVTQEVIRH-KEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGN 1380
+ ++Q +E+ R +E R+E++ Q + + L EE Q++ ++ +K
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR------- 951
Query: 1381 VTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMS-EEVEEMATLEE 1439
++E ++ ++K K +K +E+ +G+ + ++ER+ E EE+ EE
Sbjct: 952 -------RRQERERQYRKDKKLQQK---EEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 1440 KVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQA 1499
+++++E + R W+ + DE +Q + + +EE EKR LQE E+ ++
Sbjct: 1002 QLLREEREK---RRRQEWERQYRKKDELQQ------EEEQLLREEREKRRLQERERQYRE 1052
Query: 1500 GEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
E+L EEE L +++ E ++ E + +E+ ++EE++ EE R +E+E+
Sbjct: 1053 EEELQQEEEQLLGEER----ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEE--RKLA 1617
Q EE+ QEE + R R EK+R QE + +EEE++ QEE QL +EE ++
Sbjct: 1109 QCREEEELQQEEEQLLREER-----EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163
Query: 1618 QAYVKITQDDREMAQAEGKFAQKE-ETLAQRGEKLSQEAEKLA-QKRKKLAK-------- 1667
Q + +++ E+ Q E + ++E E Q E+ +E E+L QKRK+ +
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 1668 KWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEE 1727
KW+ +E + +N +++E+ R++ + L E +E + + E
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 1728 LSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQH 1787
W Q+ + E+++L EE+ A +R++ S+EE +L +EE +EK + +
Sbjct: 1284 RRW------QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER---EEKRRRQET 1334
Query: 1788 KEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLA 1847
K EEE+ L + EQ + ++ + + RE + E+ +K L +E++
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ---------GRKFLEEEQRLRR 1385
Query: 1848 QEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKE 1907
QE+E+ ++E L +ER ++QL Q +++ K + ++ QE++ +++E
Sbjct: 1386 QERERKFLKEEQQLRCQER----EQQLRQDRDR-----KFREEEQQLSRQERDRKFREEE 1436
Query: 1908 KLA---ETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALN 1964
+ E E+K ++ E L +++ + +E+ +L E+ Q ++ R + +E++
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 1965 LEMKR-LAEEKMRLVEGKETLSKGETP--ETSRQRKMTQVEQELFERKLSLEEKI----L 2017
E R E+++R E + + E RQRK Q EQ+L ++ + +
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Query: 2018 LHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKIL 2077
E+ L E E + E R R+ Q R+ + RK ++ + L ++ +
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRR-QEQERKFMEDEQQLRRQEGQQQLRQ 1615
Query: 2078 KALQKLTRDERKLTQ-EEIKMTKMKR-ALFVKE----RRLSIEQSKLDIKEWDFSEKRSE 2131
+ +K DE+ L + EE ++ + +R F++E RR EQ ++ F E+
Sbjct: 1616 ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQL 1675
Query: 2132 LTKDEKKLARKQ------RKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIE 2185
L + E++ R+Q R+ ++RR +E K +EE +L R+ E +EE+ +
Sbjct: 1676 LQEGEEQQLRRQERDRKFREEEQQLRRQ-ERERKFLQEEQQLRRQELERKFREEEQ--LR 1732
Query: 2186 EEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSS 2245
+E L+R+ R RK + E+ Q+ E + F EE
Sbjct: 1733 QETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE---------------E 1777
Query: 2246 EEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEV 2305
+ +EREE++ R +E R+ EE + +E EE+Q+ ++ + K + +E++ + ++++ +
Sbjct: 1778 QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL 1837
Query: 2306 FEEKE-EIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRE 2364
+E++ + +EE+ + EE+ EEE R +E +K ++ ++ Q+++ R R+
Sbjct: 1838 RQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQ 1897
Query: 2365 RVLSILRGVPHGKGRAIRLG 2384
V I G GR + G
Sbjct: 1898 -VGEIKSQEGKGHGRLLEPG 1916
Score = 240 bits (613), Expect = 1e-62
Identities = 245/1053 (23%), Positives = 505/1053 (47%), Gaps = 74/1053 (7%)
Query: 1346 EEEQAQKKARDML----GLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPK 1401
EE++A+ ++ L EE Q + + + EPG K ++E+++ + +
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQK---RQEQERELAEGEE 153
Query: 1402 QGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWK 1461
Q K + E++ + + E +R +E EE EE++ +G E P + +
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET--EEFPDEEQLR 211
Query: 1462 KAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEK--LSPEEEMLQEDKKLKWE 1519
+ E ++ + R+ + + E + R+ QEEE+ + L EEE LQE++ +
Sbjct: 212 RR--ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 1520 EWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHR 1579
E ++ E + + +E + + +EE ++ + RE + + +Q EE+R QEE +
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ-EEERREQQEERR-----E 323
Query: 1580 KRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQ 1639
++ R E++ + E++L +E+E+ +++ + QEE + Q + +++R Q +
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 1640 KEETLAQRGEKLSQEAEKLAQ---KRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQK 1696
+ E +R ++L +E + + +R++ ++ +++ RE++ ++ + E K+ ++
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR 443
Query: 1697 VEELP-QREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKK------- 1748
+ L ++E+ DW ++E E E E ++L +EE +E +EE+++
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Query: 1749 ---LAEEEEALAWQREKLSEEETKLAQE---EELLIQEKEKLAQHKEKMPEEEERLGRKR 1802
L E+E QR K EEE +L Q E+ L +E+E+ + K EE+ +R
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563
Query: 1803 EQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLY 1862
EQ ++++ + ++R++ + EE + ++ Q++ L Q K E+ + +R+E L
Sbjct: 564 EQRLKREQE--ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621
Query: 1863 NKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS 1922
+E ++QL++ + + + Q+ + + +E +K++E+ E++L + +
Sbjct: 622 REEPEEERRQQLLKSEEQE---ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678
Query: 1923 LAKKQEKLAQEKMKLALEKAMVQGKK---RLRGELDIAKEEKALNLEMKRLAEEKMRLVE 1979
++QE LA+E+ + A E+ + K +L E D A++ K + K+ + + + E
Sbjct: 679 ERREQE-LAEEEQEQARERIKSRIPKWQWQLESEAD-ARQSKVYSRPRKQEGQRRRQEQE 736
Query: 1980 GKETLSKGETPETSRQRKMTQVEQELFERKLS----LEEKILLHEDRILAMEESEIAKGK 2035
K + E +R Q ++E R + EEK R+ A + + +
Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA--RPPLREQR 794
Query: 2036 LEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDER--KLTQE 2093
R + + QR L + K ++R+ +E K + L+ ++L R ER +L +E
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE--KELQFLEEEEQLQRRERAQQLQEE 852
Query: 2094 EIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRM 2153
E + + + ERR S EQ + W E+R Q +L + + +
Sbjct: 853 EDGLQEDQ------ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906
Query: 2154 INKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKF 2213
+EE++ EE + R+ + EEE +EEE + +R R+R+E +R + +K
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEE-REEEEEREEEEVREEEEERKEE 2272
+ +++ EE + + ++E L EEE+ REE E+R +E E + +K+E
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE-WERQYRKKDE 1025
Query: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCS 2332
+ EE+Q+ +EE EK++ +QE+E + E+EE+ EEE + L +E E
Sbjct: 1026 LQQEEEQLLREEREKRR---------LQERERQYREEEELQQEEE-QLLGEERETRRRQE 1075
Query: 2333 LEEEVDREKEILKKEKQFKLQEQRRKSLRGRER 2365
LE + +E+E+ ++E+Q +E ++ + RER
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Score = 207 bits (526), Expect = 2e-52
Identities = 204/929 (21%), Positives = 455/929 (48%), Gaps = 111/929 (11%)
Query: 1492 EEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVS 1551
+EEK + K S ++ QE+ + ++E + E + ++++ + E E+ EE S
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 1552 REGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQ 1611
EK++++ + R ++E W + + R E++RA+EE Q + E +
Sbjct: 156 ----EKQERLEQRDRQRRDEELWRQRQEWQER-EERRAEEE----QLQSCKGHETEEFPD 206
Query: 1612 EERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAE-KLAQKRKKLAKKWE 1670
EE+ + +++ + RE +K++ +R +++ QE E K +KR+ + +K E
Sbjct: 207 EEQLRRRELLELRRKGRE---------EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE 257
Query: 1671 KVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSW 1730
+ +EEE ++ +L E + +++ +L ++E + QE+E Q+ E +
Sbjct: 258 EKLQEEEPQRQR--ELQEEE----EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311
Query: 1731 KEEELNQEEGKLVEEKKKLAEE--EEALAWQREKLSEEETKLAQEEELLIQE--KEKLAQ 1786
+E QEE + +E+++ EE E+ L ++E+ E++ + QEEE Q+ +E+ +
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Query: 1787 HKEKMPEEEERLGR----KREQLIEKKMKLAQ----KRERWINSMEELTKNKMILYQKKN 1838
+E+ E++L R +REQ + ++ +L + +RE+ + ++L + + + +++
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Query: 1839 LAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQE 1898
E+K+ + +E+ +R++ +ER K++ +++ + L + +E+ +E
Sbjct: 432 ERHEQKHEQERREQRLKREQ-----EERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 1899 KETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAK 1958
+ ++++E+ + E++ E L ++QE+ ++++K E+ +Q +RLR E + +
Sbjct: 487 RWLKLEEEERREQQERR----EQQLRREQEERREQRLKRQEEEERLQ--QRLRSEQQLRR 540
Query: 1959 EEKALNLEMKRLAEEKMRLVEGKETLSKGETPETS----------RQRKMTQVEQELFER 2008
E++ ++ + EEK E +E K E E RQ+++ + ++E E+
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 2009 KLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV---QGQRKLAKASRKLIKKRES 2065
+L EE L ++ E + + + E R Q++ Q +R+ + R+ ++RE
Sbjct: 601 RLKREEVERLEQEE---RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 2066 LSK---EPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKE 2122
K E +L + LK + R E++L +EE + + E+ K I +
Sbjct: 658 RLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR--------------ERIKSRIPK 703
Query: 2123 WDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVI------- 2175
W + + SE + K+ + RK + RR +EEK ES+L + E
Sbjct: 704 WQW-QLESEADARQSKVYSRPRKQEGQRRRQ-EQEEKRRRRESELQWQEEERAHRQQQEE 761
Query: 2176 -----------LDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEE 2224
+++ E G + P L+ + ++ A+ + +++F + +E E
Sbjct: 762 EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821
Query: 2225 HFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEE 2284
E E L LE++E L + ER ++ + EE+ ++E++E R+ +E+ +++ +
Sbjct: 822 RQRREREKELQFLEEEEQL---QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 2285 EEKKKKK------KEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVD 2338
EE++K++ K +E++++++++ +E+EE + EE E +E+E + EE++
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE-EEQLQ 937
Query: 2339 REKEILKKEKQFKLQEQRRKSLRGRERVL 2367
+E+E L +E++ K + Q R+ +++ L
Sbjct: 938 QEEEQLLREEREKRRRQERERQYRKDKKL 966
Score = 175 bits (443), Expect = 7e-43
Identities = 181/808 (22%), Positives = 398/808 (49%), Gaps = 89/808 (11%)
Query: 1580 KRARAEKKRAQ-EERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFA 1638
KRAR + K + ++R+ +++ + +RQL +E + + K + +RE+A+ E + +
Sbjct: 99 KRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ--KRQEQERELAEGEEQ-S 155
Query: 1639 QKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEV--------K 1690
+K+E L QR + + E+L ++R++ ++ E+ A EE+ + KG + E +
Sbjct: 156 EKQERLEQRDRQ--RRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 1691 NILAQKVEELPQREQNLDWQEKELAQELEELEWDMEE--LSWKEEELNQEEGKLVEEKKK 1748
+L + + +++Q ++ + QE EE EW E L +EE+L +EE + +++
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP---QRQRE 270
Query: 1749 LAEEEEALA-WQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIE 1807
L EEEE L +R++L E + Q+++ L +E++ + +E+ E++E +REQ E
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE---RREQQ-E 326
Query: 1808 KKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL 1867
++ + ++RE+ + +E + + + ++ +E++ +E+ +R+E L +++L
Sbjct: 327 RREQQEERREQQLRREQEERREQQL---RREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 1868 THSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQ 1927
+ Q++ + + + + E++L +E++ ++E+ E++L + ++ + +
Sbjct: 384 RREQ----QLRREQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQEE-ERHE 435
Query: 1928 EKLAQEKMKLALEKAMVQGKKRLRGELDIAK-EEKALNLEMKRLAEEKMRLVEGKETLSK 1986
+K QE+ + L++ + + L+ E + + E++ ++KR EE+ R E L +
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR--ERWLKLEE 493
Query: 1987 GETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046
E E ++R+ Q+ +E ER+ E R+ EE E + +L +
Sbjct: 494 EERRE-QQERREQQLRREQEERR----------EQRLKRQEEEERLQQRLRSEQ------ 536
Query: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFV 2106
Q +R+ + +L+K+ E E + + LK Q+ RD+ +EE + ++KR
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE--- 593
Query: 2107 KERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESK 2166
+E RL + +++ + E+R + K E+ ++++L + EE+ + +
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQL-------LKSEEQEERRQQQ 646
Query: 2167 LARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHF 2226
L R+ E E ++ EE L++R ++ E +R +E+ ++ ++ ++ E
Sbjct: 647 LRREQQE-----RREQRLKREEEEERLEQRLKREHEEER----REQELAEEEQEQARERI 697
Query: 2227 SEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEE 2286
+ +LE + + R ++E + +EE+ R+ E E ++ +EEE
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE-----LQWQEEE 752
Query: 2287 KKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDE----EEEEESCSLEEEVDREKE 2342
+ ++++ EE Q ++ ++ + E SE + LS E+ E EE RE+
Sbjct: 753 RAHRQQQ---EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQR 809
Query: 2343 ILKKEKQFKLQEQRRKSLRGRERVLSIL 2370
L +E++ +EQRR+ R RE+ L L
Sbjct: 810 FLPEEEE---KEQRRRQRREREKELQFL 834
Score = 125 bits (313), Expect = 8e-28
Identities = 121/530 (22%), Positives = 258/530 (48%), Gaps = 63/530 (11%)
Query: 1846 LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKK 1905
L +EK KE+LL ++ + ++ F Q+EE+ Q ++
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRR-----------FEPRDRQLEEEPGQ------RR 137
Query: 1906 KEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNL 1965
++K E E++L + E+ ++KQE+L Q + E+ Q ++ E A+EE+ +
Sbjct: 138 RQKRQEQERELAEGEEQ-SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSC 196
Query: 1966 EMKRLAE----EKMRLVEGKETLSKG-ETPETSRQRKMTQVEQELFERKLSLEEKILLHE 2020
+ E E++R E E KG E + R+ + +V QE E++ E +L E
Sbjct: 197 KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKE 256
Query: 2021 DRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKAL 2080
+ L EE + QR + + +L K R+ +++ ++ + + + L
Sbjct: 257 EEKLQEEEPQ----------RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 2081 QKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLA 2140
++ +ER+ QEE + + +R + R + + + E+R + + E++
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQ--------EERREQQLRREQEEE 358
Query: 2141 RKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKR 2200
R++++L + + E+ E +L R+ L E++ E++ L+R + R
Sbjct: 359 RREQQLRREQEE--ERREQQLRREQQLRREQQ---LRREQQLRREQQ-----LRREQQLR 408
Query: 2201 KEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEE-----EREEEE 2255
+E + + + + Q+ + EE ++ E + +++ L E+EE +REEE
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHE----QERREQRLKREQEERRDWLKREEET 464
Query: 2256 EREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE 2315
ER E+E R+++ +R +EEE E+ ++ EEEE++++++ ++++ +E+EE ++ + +
Sbjct: 465 ERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE--RREQRLKRQ 522
Query: 2316 EETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRER 2365
EE E L E+ E+E +R +++LK+E++ +L+++RR+ RE+
Sbjct: 523 EEEERLQQRLRSEQQLRREQE-ERREQLLKREEEKRLEQERREQRLKREQ 571
Score = 82.0 bits (201), Expect = 8e-15
Identities = 62/276 (22%), Positives = 142/276 (51%), Gaps = 26/276 (9%)
Query: 2114 EQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSE 2173
++++ D KE ++R E +D+++ + R+L + + + +K E+E +LA +
Sbjct: 99 KRARCDGKESLLQDRRQE--EDQRRFEPRDRQLEEEPGQ--RRRQKRQEQERELAEGEEQ 154
Query: 2174 VILDDEEEGGIEEEEVIPFLKRRWRKRKE-AKRGDKPKEKFSSQVDEVESEEHFSEEME- 2231
E++ +E+ + + WR+R+E +R ++ E+ Q + E F +E +
Sbjct: 155 ----SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 2232 ---SLLDELEKQESLSSEEEEEREEEEEREEEE---------VREEEEERKEEEEGEEKQ 2279
LL+ K ++ ER++ +EEEE +R+EEE+ +EEE +++
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE 270
Query: 2280 VEKEEEEKKKKKKE----KKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEE 2335
+++EEE+ +K +++ +++EE Q+++ + E++ +EE EE E+ E+
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 2336 EVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILR 2371
+ +R ++ L++E++ + ++Q R+ R + R
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 244 bits (622), Expect = 1e-63
Identities = 178/736 (24%), Positives = 391/736 (53%), Gaps = 99/736 (13%)
Query: 1367 LKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKE--- 1423
L K + + LE T+ E KK+ + +K P + + + V ++KR++ +
Sbjct: 202 LTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFL 261
Query: 1424 ---------ERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGET 1474
+ +M + EE+ E+K+ KQE K+ W+ ++ ++ ++ +
Sbjct: 262 LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM--------WRQEERLREQEGKMREQE 313
Query: 1475 RKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSK 1534
K W+ EKRL ++E++L + ++L ++E+ +++++++ E+ +++WE +
Sbjct: 314 EKMWRQ-----EKRLREQEKELREQEKELREQKELREQEEQMQ-EQEEKMWE-------Q 360
Query: 1535 EQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQE--- 1591
E++ +++EE +E +EK+ + E++ QEE W + R R + E+ R QE
Sbjct: 361 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 420
Query: 1592 -------ERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETL 1644
E K QE+EK +++ + QEE ++ + K+ +++ M + E K ++EE +
Sbjct: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 480
Query: 1645 AQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKV----EEL 1700
++ EK Q+ ++L ++++KL ++ EK+ +EEK+ ++ K+ + + + Q+ +E
Sbjct: 481 WEQEEKEWQQ-QRLPEQKEKLWEQ-EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 538
Query: 1701 PQREQNLDWQEKELAQELEELEWDMEE-----------LSWKEEELNQEEGKLVEEKKKL 1749
+ +++ W+++E ++ E+ WD EE +W +EE +EE ++ E +KK+
Sbjct: 539 MREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM 598
Query: 1750 AEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKK 1809
EEEE + Q EK+ E+E K+ ++EE + +++EK+ + +EKM E+EE++ + E++ E++
Sbjct: 599 REEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQ 658
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEK-EKLAQRKENLLYNKERLT 1868
QK + W +++ + Q+K QE+K QEK EK Q +E +++E++
Sbjct: 659 RLPEQKEKLW--------EHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
Query: 1869 HSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQE 1928
+ + + E+K+ +E+E + +++EK+ E E+K+ + E+ + +++E
Sbjct: 711 EEES---------------MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
Query: 1929 KLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMK-RLAEEKMR----LVEGKET 1983
K+ +++ K+ ++ + + K++L + ++EK E K R EEKMR + G+E
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815
Query: 1984 LSKGETPET--------SRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGK 2035
+G+ + ++ KM E++++ ++ +EEK+ E+++ E+ E +G+
Sbjct: 816 KMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKM--REQEEKMRGQ 873
Query: 2036 LEFTRGQRIFVQGQRK 2051
E R Q ++GQ +
Sbjct: 874 EEKMREQEEKMRGQEE 889
Score = 231 bits (590), Expect = 6e-60
Identities = 189/733 (25%), Positives = 401/733 (54%), Gaps = 83/733 (11%)
Query: 1604 QEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRK 1663
QE+ LA+ E+ Q VK + R++ +A+ Q + Q E++ ++ E+L ++ K
Sbjct: 231 QEKLPLAESEKSEIQLNVKELK--RKLERAKFLLPQVQTNTLQ--EEMWRQEEELREQEK 286
Query: 1664 KLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEW 1723
K+ K+ EK+ R+EE+L ++ GK+ E + + ++ + L ++E+ L QEKEL +E +EL
Sbjct: 287 KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL-REQKELRE 345
Query: 1724 DMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEK 1783
E++ +EE++ ++E K+ E+++K+ +EE L Q +++ E+E K+ +EE + ++ E+
Sbjct: 346 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 405
Query: 1784 LAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEK 1843
L + +E+M E+E+ + + EKKM+ +K+ R + E++ + + I ++K + +E+
Sbjct: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR--DQEEKMQEEERIREREKKMREEE 463
Query: 1844 KNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVI 1903
+ + +++EK+ +++EN ++ +E +++L + K KL K+ Q EEK+ +++E +
Sbjct: 464 ETMREQEEKMQKQEEN-MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ-EEKIWEQEEKIR 521
Query: 1904 KKKEKLAETEK-----KLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAK 1958
++E + +K K+ + ED + +++EK+ ++ K+ ++ ++ K + + + +
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581
Query: 1959 EEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILL 2018
EEK E R E+KMR E +E + + E ++ KM + E++++E+ EEK+
Sbjct: 582 EEKMREEERMREREKKMR--EEEEMMREQEEKMQEQEEKMQEQEEKMWEQ----EEKMQE 635
Query: 2019 HEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILK 2078
E+++ EE + Q + ++L +++E L + ++ ++
Sbjct: 636 QEEKMWEQEEK----------------MWEQEEKMWEQQRLPEQKEKLWE-----HEKMQ 674
Query: 2079 ALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKK 2138
+K+ E K+ ++E KM K + EQ K K WD E ++E+
Sbjct: 675 EQEKMQEQEEKIWEQE-KMEKKTQ-----------EQEK---KTWD-----QEKMREEES 714
Query: 2139 LARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWR 2198
+ +++K+ + M +EEKM E+E K+ + E + ++EE E+EE
Sbjct: 715 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEE--MWEQEEKMWEQEE---------- 762
Query: 2199 KRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEER- 2257
K E +R + KEK ++++ +E E+ E + D+ +E + +EE+ R +EE+
Sbjct: 763 KMWEQQRLPEQKEKLWEH-EKMQEQEKIWEQEEKMRDQ---EEKMRGQEEKMRGQEEKMR 818
Query: 2258 -EEEEVREEEEERKEEEE---GEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIM 2313
+EE++ +EE+ +EE G+E+++ +E EK ++K + ++E+++E+EE +EE M
Sbjct: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQE-EKMEEKMQGQEEKMREQEEKMRGQEEKM 877
Query: 2314 SEEETESLSDEEE 2326
E+E + EE+
Sbjct: 878 REQEEKMRGQEEK 890
Score = 224 bits (572), Expect = 7e-58
Identities = 186/773 (24%), Positives = 403/773 (52%), Gaps = 86/773 (11%)
Query: 1635 GKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNI-- 1692
G+ + ++ R +K + E+L ++R L+ + + E+L KK +L E +
Sbjct: 179 GELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAE 238
Query: 1693 ------------LAQKVEE----LPQREQNL----DWQEKELAQELEELEWDMEELSWKE 1732
L +K+E LPQ + N W+++E +E E+ EE W++
Sbjct: 239 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 298
Query: 1733 EE-LNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEK------EKLA 1785
EE L ++EGK+ E+++K+ +E+ L Q ++L E+E +L +++EL QE+ EK+
Sbjct: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMW 358
Query: 1786 QHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKN 1845
+ +EKM E+EE++ R+ E+L E++ ++ ++ ++ + E + + L +K+ +E++
Sbjct: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 418
Query: 1846 LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKK 1905
+ ++ EK+ R+E + +E+ T +++ +Q + ++ K + + EE + +++E + K+
Sbjct: 419 MWEQVEKM--REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476
Query: 1906 KEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNL 1965
+E + E E+K Q + +K++ QEKM+ EK Q +K I +E+
Sbjct: 477 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK-------IRDQEEMWGQ 529
Query: 1966 EMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILA 2025
E K +EKMR + E ++ KM EQ++++++ +E+K E +
Sbjct: 530 EKKMWRQEKMR---------EQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
Query: 2026 MEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTR 2085
EE ++ + ++ + +K+ ++ E + ++ K+ + +K+
Sbjct: 581 QEEK----------------MREEERMREREKKMREEEEMMREQEEKMQE---QEEKMQE 621
Query: 2086 DERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRK 2145
E K+ ++E KM + + ++ +E ++ ++ K+ W+ + L + ++KL ++
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM----WE----QQRLPEQKEKLWEHEKM 673
Query: 2146 LANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKR 2205
+ +M +EEK+ E+E K+ +K E ++ + EEE + +++ R+ +E R
Sbjct: 674 --QEQEKMQEQEEKIWEQE-KMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730
Query: 2206 GDKPKEKFSSQVDEV-ESEEHFSEEMESLLDELEK---QESLSSEEEEEREEEEEREEEE 2261
+ +EK Q +++ E EE E+ E + ++ EK Q+ L ++E+ E E+ +E+E+
Sbjct: 731 --EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Query: 2262 VREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESL 2321
+ E+EE+ +++EE Q EK +++K + +++K QE E+++ ++E++ +EE +
Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQE-EKMWGQEEKMWGQEE-KMW 846
Query: 2322 SDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVP 2374
EE+ EE +EE RE+E + ++ K++EQ K +RG+E + + P
Sbjct: 847 GQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEK-MRGQEEKIYCVGSPP 898
Score = 223 bits (568), Expect = 2e-57
Identities = 171/707 (24%), Positives = 385/707 (54%), Gaps = 51/707 (7%)
Query: 1483 EEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEE 1542
EE +K+ + +EKL A + S E ++ ++ K K E K + + ++ +E+ ++ EE
Sbjct: 221 EELKKKNAELQEKLPLAESEKS-EIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE 279
Query: 1543 EVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL 1602
E+ +E+ R+ EEK + +E+R ++E K K R EK+ ++E++L +E+EK
Sbjct: 280 ELREQEKKIRKQEEKMWR--QEERLREQEGKMREQEEKMWRQEKRLREQEKEL-REQEKE 336
Query: 1603 AQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKR 1662
+E+++L ++E +M + E K ++EE + ++ EK+ ++ E+L ++
Sbjct: 337 LREQKELREQE--------------EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE 382
Query: 1663 KKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELE 1722
K++ ++ +K+ +EE++ ++ +L E +E REQ W++ E +E ++++
Sbjct: 383 KQMREQEQKMRDQEERMWEQDERLRE---------KEERMREQEKMWEQVEKMREEKKMQ 433
Query: 1723 WDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEE------L 1776
+ E+ + +EE QEE ++ E +KK+ EEEE + Q EK+ ++E + ++EE
Sbjct: 434 -EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 492
Query: 1777 LIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQK 1836
L ++KEKL + +EKM E+EE++ + E++ +++ Q+++ W +++M ++
Sbjct: 493 LPEQKEKLWE-QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
Query: 1837 KNLAQEKKNLAQEK--EKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEK 1894
K QE+K QE+ EK Q +E +++E ++++ + + K+ +++ + EEK
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 1895 LTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGEL 1954
+ +++E + +++EK+ E E+K+ + E+ + +++EK+ +++ K+ ++ + + K++L
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671
Query: 1955 DIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVE-QELFERKLSLE 2013
+ ++EK E K +EKM E ++ + +T Q KM + E E+K+ E
Sbjct: 672 KMQEQEKMQEQEEKIWEQEKM------EKKTQEQEKKTWDQEKMREEESMREREKKMREE 725
Query: 2014 EKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESL--SKEPA 2071
E+++ ++ + +E ++ + + E + + + K+ + R L +++E L ++
Sbjct: 726 EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR-LPEQKEKLWEHEKMQ 784
Query: 2072 KLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKL---DIKEWDFSEK 2128
+ KI + +K+ E K+ +E KM + + +E ++ ++ K+ + K W EK
Sbjct: 785 EQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEK 844
Query: 2129 R-SELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEV 2174
+ K E+K+ ++ K+ + +M +EEKM E+E K+ + ++
Sbjct: 845 MWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 219 bits (559), Expect = 2e-56
Identities = 158/638 (24%), Positives = 358/638 (56%), Gaps = 58/638 (9%)
Query: 1334 QEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEK 1393
QE + +E RE+E+ +K + + +E ++ ++GK + M ++ + E+
Sbjct: 271 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGK----MREQEEKMWRQEKRLREQ 326
Query: 1394 KTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIER 1453
+K ++ K +++++++ + + +M ++E M E+ E+M EEK+ +QE +L E+
Sbjct: 327 ---EKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 383
Query: 1454 TPSWQDWK------KAWDEWKQVHGET---RKSWKAWKE----EWEKRLLQEEEKLHQAG 1500
Q+ K + W++ +++ + R+ K W++ EK++ ++E+K
Sbjct: 384 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE 443
Query: 1501 EKLSPEEEMLQEDKKLKWEE---------WKQVWENMLSSKSKE---QQYKDEEEVTLEE 1548
EK+ EE + + +KK++ EE ++ ENM + KE Q+ +++E E+
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503
Query: 1549 EVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQ 1608
E +E EEK + E++ I+++ + +K R EK R QE++ QEE+ QE++
Sbjct: 504 EKMQEQEEK---IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
Query: 1609 LAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKK 1668
QEER K TQ+ + + + ++EE + +R +K+ +E E + ++ +K+ ++
Sbjct: 561 WDQEER-----MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615
Query: 1669 WEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEEL 1728
EK+ +EEK+ ++ K+ E + + ++ E++ ++E+ + W+++ L ++ E+L W+ E++
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM-WEQQRLPEQKEKL-WEHEKM 673
Query: 1729 SWKEEELNQEEGKLVEEKK--KLAEEEEALAWQREKLSEEET------KLAQEEELLIQE 1780
++E++ ++E K+ E++K K +E+E W +EK+ EEE+ K+ +EEE++ ++
Sbjct: 674 Q-EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ 732
Query: 1781 KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLA 1840
+EK+ + +EKM E+EE + + E++ E++ K+ +++R E+L +++ + Q+K
Sbjct: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM-WEQQRLPEQKEKLWEHEKMQEQEKIWE 791
Query: 1841 QEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL-GMFNKILAQVEEKLTQEK 1899
QE+K + ++EK+ ++E + +E++ ++++ + K+ G K+ Q E+ QE+
Sbjct: 792 QEEK-MRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEE 850
Query: 1900 ETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKL 1937
K +EK+ E+K+ + E+ + ++EK+ +++ K+
Sbjct: 851 ----KMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKM 884
Score = 202 bits (514), Expect = 4e-51
Identities = 164/600 (27%), Positives = 317/600 (52%), Gaps = 64/600 (10%)
Query: 1294 LKKESKVLLEDLDW----DVVPPEKKPIFIQEGAIREDMIQGVTQEV-IRHKEVMPREEE 1348
L+++ K L E + + + +++ ++ QE +RE + QE + +E RE+E
Sbjct: 330 LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389
Query: 1349 QAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQ 1408
Q + + + E+ + + +K +++ E M +++ K E+K Q+ K+ R +
Sbjct: 390 QKMRDQEERMW-EQDERLREKEERMREQEK----MWEQVEKMREEKKMQEQEKKTRDQEE 444
Query: 1409 KERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWK 1468
K ++ +I+ + E+ M EE E M EEK+ KQE + W++ EW+
Sbjct: 445 KMQEEERIR----EREKKMREEEETMREQEEKMQKQEENM-----------WEQEEKEWQ 489
Query: 1469 QVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENM 1528
Q +K K W++E ++ ++EEK+ + EK+ +EEM W + K++W
Sbjct: 490 QQRLPEQKE-KLWEQE---KMQEQEEKIWEQEEKIRDQEEM--------WGQEKKMWRQE 537
Query: 1529 LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQ--RHIQEEHKWARIHRKRARAEK 1586
+ ++Q ++ EE++ +E+ + EE+ ++ T+EQ + +E K R R R EK
Sbjct: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER-EK 596
Query: 1587 KRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEE---- 1642
K +EE + ++EEK+ ++E ++ ++E K+ + K+ + + +M + E K ++EE
Sbjct: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656
Query: 1643 --TLAQRGEKL-----SQEAEKLAQKRKKL--AKKWEKVAREEEKLAKKGGKLAEVKNIL 1693
L ++ EKL QE EK+ ++ +K+ +K EK +E+EK K+ E +++
Sbjct: 657 QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR 716
Query: 1694 AQ----KVEELPQREQNLDWQE-KELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKK 1748
+ + EE REQ QE +E QE EE W+ EE W++EE E+ +L E+K+K
Sbjct: 717 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEK 776
Query: 1749 LAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEK 1808
L E E+ ++EK+ E+E K+ +EE + ++EK+ +EKM +EE++ + E++ +
Sbjct: 777 LWEHEK--MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQ 834
Query: 1809 KMKL-AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL 1867
+ K+ Q+ + W EE + KM ++K QE+K QE EK+ +++E + +E++
Sbjct: 835 EEKMWGQEEKMW--GQEEKMEEKMQGQEEKMREQEEKMRGQE-EKMREQEEKMRGQEEKI 891
Score = 142 bits (359), Expect = 4e-33
Identities = 130/563 (23%), Positives = 295/563 (52%), Gaps = 54/563 (9%)
Query: 1914 KKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKK-RLRGELDIAKEEKA-LNLEMKRLA 1971
KK + + L K+++ L+ E + + ++ K L+ +L +A+ EK+ + L +K L
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKEL- 251
Query: 1972 EEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSL---EEKILLHEDRILAMEE 2028
K +L K L + +T + Q +M + E+EL E++ + EEK+ E+R L +E
Sbjct: 252 --KRKLERAKFLLPQVQT--NTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER-LREQE 306
Query: 2029 SEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDER 2088
++ + + + R ++ + +++L + ++L +++E +E ++ + +K+ E
Sbjct: 307 GKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQE----EQMQEQEEKMWEQEE 362
Query: 2089 KLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKE---WDFSEK---RSELTKDEKKL--- 2139
K+ ++E KM + + L+ +E+++ ++ K+ +E W+ E+ + E ++++K+
Sbjct: 363 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 422
Query: 2140 ---ARKQRKLANKMRRMINKEEKMTEEE-----SKLARKHSEVILDDEEEGGIEEEEVIP 2191
R+++K+ + ++ ++EEKM EEE K R+ E + + EE+ +EE +
Sbjct: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 482
Query: 2192 FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEER 2251
++ W++++ ++ KEK Q E EE E+ E + D+ +E E++ R
Sbjct: 483 QEEKEWQQQRLPEQ----KEKLWEQEKMQEQEEKIWEQEEKIRDQ---EEMWGQEKKMWR 535
Query: 2252 EEEEEREEEEVREEEEERKEEEE---GEEKQVEKEEEEKKKK-----KKEKKKEEVQEKE 2303
+E+ +E+++ E+EE+ +++E+ +E+++EK+ +E++KK +K +++E ++E+E
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRERE 595
Query: 2304 EVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGR 2363
+ E+EE+M E+E + +E+EE +EE E+E +E++ K+ EQ K
Sbjct: 596 KKMREEEEMMREQEEKM----QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 651
Query: 2364 ERVLSILRGVPHGKGRAIRLGVL--KSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKAT 2421
E++ R +P K + + + +++ E ++ +++ +W+ +K
Sbjct: 652 EKMWEQQR-LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
Query: 2422 VVEIPRKFLGTMDKEREVMGKYE 2444
E R+ M +E E+M + E
Sbjct: 711 EEESMREREKKMREEEEMMREQE 733
Score = 90.9 bits (224), Expect = 2e-17
Identities = 117/621 (18%), Positives = 285/621 (45%), Gaps = 75/621 (12%)
Query: 994 QKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENLTLSHRDEKPAFSLDV 1053
++Q+ RE ++QM +E + + + + E+RL E E+ +
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 1054 SM---PSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKK--HSQKWLRGLKKTKERDS 1108
M L+ + E+ ++ + +++ Q KK ++ ++ ++ +ER+
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREK 457
Query: 1109 KQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQ-EKDISKDHIAL 1167
K E + E E ++ +E +++ Q +L + + E++ ++
Sbjct: 458 KMREEEETMREQEE-----KMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
Query: 1168 TLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGAS 1227
++ +KIRD+ + +K+ ++ K + +E ++ +E EQ + + +
Sbjct: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM----- 567
Query: 1228 GISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEMLVDRHPSWELF 1287
+++ + +W + R+ + KM E +EM+ ++ +
Sbjct: 568 ---EKKTQEQEKKTWDQEEKMREEERMREREKKMREE---------EEMMREQEEKMQEQ 615
Query: 1288 QEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREE 1347
+E + ++E K+ ++ + + +++ ++ QE + E +E + ++ +P ++
Sbjct: 616 EE--KMQEQEEKMWEQE---EKMQEQEEKMWEQEEKMWEQ------EEKMWEQQRLPEQK 664
Query: 1348 EQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAV 1407
E+ + + ++E + + ++ +K+ E M K+ ++E+K Q+ ++
Sbjct: 665 EKLWEHEK----MQEQEKMQEQEEKIWEQE----KMEKKTQEQEKKTWDQEKMREEESMR 716
Query: 1408 QKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEW 1467
++E+K+ + + M ++E M E+ E+M EE++ +QE K+ W+ +K W++
Sbjct: 717 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM--------WEQEEKMWEQ- 767
Query: 1468 KQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKL-SPEEEMLQEDKKLKWEEWKQVWE 1526
+++ + K W+ K + ++++ ++EEK+ EK+ EE+M +++K++ +E +++W
Sbjct: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQE-EKMW- 825
Query: 1527 NMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEK 1586
+E+ + EE++ +EE EEK EE+ QEE + R + EK
Sbjct: 826 -----GQEEKMWGQEEKMWGQEEKMWGQEEK----MEEKMQGQEE-------KMREQEEK 869
Query: 1587 KRAQEERKLAQEEEKLAQEER 1607
R QEE+ QEE+ QEE+
Sbjct: 870 MRGQEEKMREQEEKMRGQEEK 890
Score = 43.1 bits (100), Expect = 0.004
Identities = 70/391 (17%), Positives = 163/391 (41%), Gaps = 53/391 (13%)
Query: 1070 EESEVAIKPSKGQRRGQAGVKK--HSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAA 1127
+E ++ + + +++ Q KK ++ +R ++ +ER+ K E + E E +
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615
Query: 1128 PIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQK 1187
+M+E W + + + + QE+ + + + + Q++ ++++K +K
Sbjct: 616 EEKMQEQEE-KMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ--QRLPEQKEKLWEHEK 672
Query: 1188 LKKKHKKKGKEAKVINEETTPP-VMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDL 1246
++++ K + +E K+ +E EQ + + R + R + +++
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE----EEEM 728
Query: 1247 CRLMALRISGSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLD 1306
R ++ + KM E +EM WE +E K+
Sbjct: 729 MREQEEKMQEQEEKMQEQ--------EEEMWEQEEKMWE----------QEEKM------ 764
Query: 1307 WDV--VPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQ 1364
W+ +P +K+ ++ E ++ I +++ +E M +EE+ + + M G EE
Sbjct: 765 WEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKM 824
Query: 1365 VILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEE 1424
G++ +++ +EEK Q+ G++ +E+ G+ + +M ++E
Sbjct: 825 W----GQE------------EKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQ-EEKMREQE 867
Query: 1425 RDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455
M + E+M EEK+ QE K+ + P
Sbjct: 868 EKMRGQEEKMREQEEKMRGQEEKIYCVGSPP 898
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 215 bits (547), Expect = 6e-55
Identities = 169/707 (23%), Positives = 386/707 (54%), Gaps = 58/707 (8%)
Query: 1338 RHKEVMPREEEQAQKKARDMLGLEETQV---ILKKGKKVIFLEPGNVTMGKEISKK-EEK 1393
+H+E + RE E AQ +L ++T++ + E GN+ K+++ +
Sbjct: 78 QHQEALRREIE-AQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLAGRLHHS 136
Query: 1394 KTFQKSPKQGRKAVQK-ERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEG----KL 1448
F ++ AV +K + E+TKE +S E+ E++ K+ KL
Sbjct: 137 WHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL 196
Query: 1449 VMIERTPSW-----QDWKKAWDEWK----QVHGETRKSWKAWKEEWEKRLLQEEEKLHQA 1499
+ E S ++ K+ + K QV T + + W++E E R ++E+K+ +
Sbjct: 197 RLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQE-EMWRQEEELR--EQEKKIRKQ 253
Query: 1500 GEKLSPEEEMLQEDK-KLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKE 1558
EK+ +EE L+E + K++ +E K ++++ E+E L E+ E+K+
Sbjct: 254 EEKMWRQEERLREQEGKMREQEEKM---------RRQEKRLREQEKELREQEKELREQKK 304
Query: 1559 QQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQ 1618
+ EEQ QEE W + E+K ++E K+ ++EE+L ++E+Q+ ++E+K+
Sbjct: 305 LREQEEQMQEQEEKMWEQ--------EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD 356
Query: 1619 AYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEK 1678
++ + D + + E + ++E+ Q E+ QE E++ ++ KK+ ++ E + +EEK
Sbjct: 357 QEERMWEQDERLREKEERMREQEKMWEQ--EEKMQEEERIREREKKMREEEETMREQEEK 414
Query: 1679 LAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQE 1738
+ K+ + E + Q+ + LP++++ L W E+E QE EE W+ EE +EE+ +
Sbjct: 415 MQKQEENMWEQEEKEWQQ-QRLPEQKEKL-W-EQEKMQEQEEKIWEQEEKIRDQEEMWGQ 471
Query: 1739 EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERL 1798
E K+ + +K+ E+E+ + Q EK+ ++E K+ +EE + ++ E+L + +E+M E++++
Sbjct: 472 EKKMWRQ-EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERM-REQKKM 529
Query: 1799 GRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKE 1858
++ E++ E+K Q+++ W + E++ + + + ++K + +E++ + +++EK+ +++E
Sbjct: 530 WQQEEKMREEKKTQEQEKKTW-DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE 588
Query: 1859 NLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEE--KLTQEKETVIKKKEKLAETEKKL 1916
+ +E++ ++++ + + K+ + + + EE K+ +++E + +++EK+ E E+K+
Sbjct: 589 KMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKM 648
Query: 1917 VQVEDSLAKKQEKLAQEKMKL-ALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKM 1975
+ E+ + +++EK+ +++ K+ E+ M + +++++G+ + +E++ E R EEKM
Sbjct: 649 WEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQE----EKMRGQEEKM 704
Query: 1976 RLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDR 2022
G+E G+ + Q +M + E+ + ++K ++E++ HE+R
Sbjct: 705 ---WGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEER 748
Score = 204 bits (520), Expect = 8e-52
Identities = 185/757 (24%), Positives = 395/757 (52%), Gaps = 84/757 (11%)
Query: 1585 EKKRAQEERKLAQEEEKLAQEE--RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEE 1642
++K+A + + A E AQ+ R L ++ +L A + +QD + +G + ++
Sbjct: 71 DEKKASHQHQEALRREIEAQDHTIRILTCQKTELETA-LYYSQDAARKFE-DGNLGESKD 128
Query: 1643 TLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAE--VKNILAQKVEEL 1700
LA R A +L + ++ +K R E+L K+ L+ +N + EEL
Sbjct: 129 -LAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITN--EEL 185
Query: 1701 PQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQR 1760
+++N + QEK E E+ E +L+ KE + E K + + + +E + Q
Sbjct: 186 --KKKNAELQEKLRLAESEKSEI---QLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQE 240
Query: 1761 EKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWI 1820
E+L E+E K+ ++EE + +++E+L + + KM E+EE++ R+ ++L E++ +L ++ +
Sbjct: 241 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEK--- 297
Query: 1821 NSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNK 1880
EL + K + Q++ + ++++ + +++EK+ +++E + +ERL +KQ+ + + K
Sbjct: 298 ----ELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 353
Query: 1881 LGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE 1940
+ + + + +E+L +EKE ++++EK+ E E+K+ Q E+ + ++++K+ +E E
Sbjct: 354 MRDQEERMWEQDERL-REKEERMREQEKMWEQEEKM-QEEERIREREKKMREE------E 405
Query: 1941 KAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQ 2000
+ M + +++++ + + E++ + +RL E+K +L E ++ + E ++ Q
Sbjct: 406 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 465
Query: 2001 VEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLI 2060
E E+K+ +EK+ ED++ EE + + + + +R++ Q +R
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDER---------- 515
Query: 2061 KKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDI 2120
L+ ++ R+++K+ Q+E KM +E + + EQ K
Sbjct: 516 ----------------LREKEERMREQKKMWQQEEKM---------REEKKTQEQEK--- 547
Query: 2121 KEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEE 2180
K WD EK ++E+++ +++K+ + M +EEKM E+E K+ R+ E + + EE
Sbjct: 548 KTWDQEEK----MREEERMREREKKMREEEEMMREQEEKMQEQEEKM-REQEEKMWEQEE 602
Query: 2181 EGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEK- 2239
+ +EE++ ++ W + +E K ++ + + + E EE E+ E + ++ EK
Sbjct: 603 KMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKM 662
Query: 2240 ---QESLSSEEEEEREEEE--EREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEK 2294
+E + +EE+ RE+EE + +EE++RE+EE+ + + EEK +EE+ +++K
Sbjct: 663 REQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQ---EEKMWGQEEKMWGQEEKMW 719
Query: 2295 KKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESC 2331
+EE++EKEE +++E M E E EE E C
Sbjct: 720 GQEEMREKEERIRDQKEKMQERLPE---HEERCSEPC 753
Score = 192 bits (487), Expect = 5e-48
Identities = 130/520 (25%), Positives = 296/520 (56%), Gaps = 38/520 (7%)
Query: 1325 REDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEET----QVILKKGKKVIFLEPGN 1380
+E+ ++ +++ + +E M R+EE+ +++ M EE + L++ +K + +
Sbjct: 239 QEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE 298
Query: 1381 VTMGKEISKKEEKKTFQKSP--KQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLE 1438
+ K++ ++EE+ Q+ +Q K ++E K+ + + + ++E+ M E+ ++M E
Sbjct: 299 LREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 358
Query: 1439 EKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQ 1498
E++ +Q+ +L E+ ++ +K W++ +++ E R E EK++ +EEE + +
Sbjct: 359 ERMWEQDERLR--EKEERMREQEKMWEQEEKMQEEERI------REREKKMREEEETMRE 410
Query: 1499 AGEKLSPEEEMLQEDKKLKW------EEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSR 1552
EK+ +EE + E ++ +W E+ +++WE + +E+ ++ EE++ +EE+
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW- 469
Query: 1553 EGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEE-----EKLAQEER 1607
G+EK+ E+ R QE+ W + + R + +K QEER Q+E E+ +E++
Sbjct: 470 -GQEKKMWRQEKMRE-QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQK 527
Query: 1608 QLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAK 1667
++ Q+E K+ + K TQ+ + + + ++EE + +R +K+ +E E + ++ +K+ +
Sbjct: 528 KMWQQEEKMREE--KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE 585
Query: 1668 KWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEE 1727
+ EK+ +EEK+ ++ K+ E Q+ + Q E+ + +E++ QE EE+ W+ EE
Sbjct: 586 QEEKMREQEEKMWEQEEKMQE------QEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEE 639
Query: 1728 -LSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQ 1786
+ +EE++ ++E K+ E+++K+ E+EE + Q EK+ E+E K+ +EE + +++EK+
Sbjct: 640 KMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRG 699
Query: 1787 HKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL 1826
+EKM +EE++ + E++ ++ ++ +K ER + E++
Sbjct: 700 QEEKMWGQEEKMWGQEEKMWGQE-EMREKEERIRDQKEKM 738
Score = 190 bits (482), Expect = 2e-47
Identities = 164/664 (24%), Positives = 348/664 (52%), Gaps = 96/664 (14%)
Query: 1712 KELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEA------------LAWQ 1759
+EL +E + L ++ + EEL ++ +L +EK +LAE E++ L
Sbjct: 162 EELTKERDALSLELYRNTITNEELKKKNAEL-QEKLRLAESEKSEIQLNVKELKRKLERA 220
Query: 1760 REKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW 1819
+ L + +T QEE + +++E+L + ++K+ ++EE++ R+ E+L E++ K+ ++ E+
Sbjct: 221 KFLLPQVQTNTLQEE--MWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM 278
Query: 1820 INSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKN 1879
+ L + + L +++ +E+K L +++E++ +++E + +E++ ++++ + +
Sbjct: 279 RRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE 338
Query: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLAL 1939
+L K + + E+K+ ++E + ++ E+L E E+++ ++QEK+ +++ K+
Sbjct: 339 RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM--------REQEKMWEQEEKMQE 390
Query: 1940 EKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMT 1999
E+ + + +K++R E + +E+ EEKM+ E E + + E E +QR
Sbjct: 391 EERIREREKKMREEEETMREQ-----------EEKMQKQE--ENMWEQEEKEWQQQRLPE 437
Query: 2000 QVEQELFERKLS-LEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRK 2058
Q E+ + K+ EEKI E++I EE + GQ K K
Sbjct: 438 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEE-----------------MWGQEKKMWRQEK 480
Query: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKL 2118
+ ++ + + ++ +K+ E+K+ +E +M + L KE R+ EQ K+
Sbjct: 481 MREQEDQMWEQE----------EKMRDQEQKMWDQEERMWEQDERLREKEERMR-EQKKM 529
Query: 2119 DIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDD 2178
W EK E EKK +++K ++ +M +EE+M E E K+ R+ E++ +
Sbjct: 530 ----WQQEEKMRE----EKKTQEQEKKTWDQEEKM-REEERMREREKKM-REEEEMMREQ 579
Query: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEV-ESEEHFSEEMESLLDEL 2237
EE+ +EE++ ++ W + +EK Q +++ E EE E+ E D++
Sbjct: 580 EEKMQEQEEKMREQEEKMWEQ----------EEKMQEQEEKMWEQEEKMWEQEEE--DKM 627
Query: 2238 EKQESLSSEEEEEREEEEER--EEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKK 2295
++QE + E+EE+ +E+EE+ E+EE E+EE+ E+E E+ Q ++E+ ++++K + +
Sbjct: 628 QEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE-EKMQGQEEKMREQEEKMQGQ 686
Query: 2296 KEEVQEKEEVFEEKEEIMSEEETESLSDEEE---EEESCSLEEEVDREKEILKKEKQFKL 2352
+E+++E+EE +EE M +E + EE+ +EE EE + +KE K +++
Sbjct: 687 EEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKE--KMQERLPE 744
Query: 2353 QEQR 2356
E+R
Sbjct: 745 HEER 748
Score = 186 bits (472), Expect = 3e-46
Identities = 170/579 (29%), Positives = 317/579 (54%), Gaps = 60/579 (10%)
Query: 1814 QKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQ 1873
+K +R+I EELTK + L +L + + E+ K +K L K RL S+K
Sbjct: 155 KKADRYI---EELTKERDAL----SLELYRNTITNEELK---KKNAELQEKLRLAESEKS 204
Query: 1874 LVQV-----KNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQE 1928
+Q+ K KL +L QV+ QE+ + +++E+L E EKK+ + E+ + +++E
Sbjct: 205 EIQLNVKELKRKLERAKFLLPQVQTNTLQEE--MWRQEEELREQEKKIRKQEEKMWRQEE 262
Query: 1929 KLAQEKMKLA-LEKAMVQGKKRLRG-ELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSK 1986
+L +++ K+ E+ M + +KRLR E ++ ++EK L E K+L E++ ++ E +E + +
Sbjct: 263 RLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELR-EQKKLREQEEQMQEQEEKMWE 321
Query: 1987 GETPETSRQRKMTQVEQELFERKLSL---EEKILLHEDRILAMEESEIAKGKLEFTRGQR 2043
E ++ KM + E+ L+E++ + E+K+ E+R+ E+ E + K E R Q
Sbjct: 322 QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERM--WEQDERLREKEERMREQE 379
Query: 2044 IFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRA 2103
+ + K+ + R I++RE +E + + + +K+ + E + ++E K + +R
Sbjct: 380 KMWEQEEKMQEEER--IREREKKMREEEETMR--EQEEKMQKQEENMWEQEEKEWQQQRL 435
Query: 2104 LFVKERRLSIEQSKLDIKE---WDFSEK---RSELTKDEKKLARKQRKLANKMRRMINKE 2157
KE+ EQ K+ +E W+ EK + E+ EKK+ R Q K+ + +M +E
Sbjct: 436 PEQKEKLW--EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR-QEKMREQEDQMWEQE 492
Query: 2158 EKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWR---KRKEAKRGDKPKEKFS 2214
EKM ++E K+ + + DE E+EE + K+ W+ K +E K+ + ++K
Sbjct: 493 EKMRDQEQKMWDQEERMWEQDERLR--EKEERMREQKKMWQQEEKMREEKKTQEQEKKTW 550
Query: 2215 SQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEE-REEEEVREEEEERKEEE 2273
Q +++ EE E + + +E +E + +EE+ +E+EE+ RE+EE E+EE+ +E+
Sbjct: 551 DQEEKMREEERMREREKKMREE---EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQ 607
Query: 2274 -----EGEEKQVEKEEEEKKKKKKE---KKKEEVQEKEEVFEEKEEIMSEEETESLSDEE 2325
E EEK E+EEE+K ++++E +++E++QE+EE E+EE M E+E +
Sbjct: 608 EEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKM----R 663
Query: 2326 EEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRE 2364
E+EE +EE RE+E + ++ K++EQ K +RG+E
Sbjct: 664 EQEEKMQGQEEKMREQEEKMQGQEEKMREQEEK-MRGQE 701
Score = 132 bits (333), Expect = 4e-30
Identities = 143/657 (21%), Positives = 310/657 (47%), Gaps = 107/657 (16%)
Query: 1739 EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERL 1798
+ KL E KKK + + W + T +++ E PE+E++
Sbjct: 19 QNKLAEAKKKFTDYRQ---WNIAGVGTRATDTKKKKINNGTNPETTTSEGCHSPEDEKKA 75
Query: 1799 GRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQ--EKKNLAQEKEKLAQR 1856
+ ++ + ++++ R + + T+ + LY ++ A+ E NL + K+ LA R
Sbjct: 76 SHQHQEALRREIEAQDHTIRILTCQK--TELETALYYSQDAARKFEDGNLGESKD-LAGR 132
Query: 1857 KENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKL 1916
+ H +L + + + ++K + E+LT+E++ + + + T ++L
Sbjct: 133 LHHSW-------HFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEEL 185
Query: 1917 VQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMR 1976
KK+ QEK++LA E+ + L +K L K +
Sbjct: 186 --------KKKNAELQEKLRLA------------------ESEKSEIQLNVKEL---KRK 216
Query: 1977 LVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKL 2036
L K L + +T + Q +M + E+EL E+ E+KI E+++ EE
Sbjct: 217 LERAKFLLPQVQT--NTLQEEMWRQEEELREQ----EKKIRKQEEKMWRQEER------- 263
Query: 2037 EFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIK 2096
R Q ++ Q + + K ++++E K L+ +K R+++KL ++E +
Sbjct: 264 --LREQEGKMREQEEKMRRQEKRLREQE----------KELREQEKELREQKKLREQEEQ 311
Query: 2097 MTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINK 2156
M + + ++ +E ++ ++ K+ +E E+ ++ + E+K+ ++ ++ + R+ K
Sbjct: 312 MQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK 371
Query: 2157 EEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPK-EKFSS 2215
EE+M E+E E+E ++EEE I +++ R+ +E R + K +K
Sbjct: 372 EERMREQEKMW-----------EQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE 420
Query: 2216 QVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEE-REEEEVREEEEERKEEE- 2273
+ E E +E + + ++L +QE + +EE+ E+EE+ R++EE+ +E++ +E
Sbjct: 421 NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 480
Query: 2274 --EGEEKQVEKEEEEKKKKKK---------------EKKKEEVQEKEEVFEEKEEIMSEE 2316
E E++ E+EE+ + +++K +K+E ++E++++++++E++ E+
Sbjct: 481 MREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK 540
Query: 2317 ETESLS----DEEE---EEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERV 2366
+T+ D+EE EEE E+ RE+E + +E++ K+QEQ K E++
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKM 597
Score = 131 bits (330), Expect = 8e-30
Identities = 101/445 (22%), Positives = 224/445 (50%), Gaps = 70/445 (15%)
Query: 1325 REDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMG 1384
+E+ +Q +++ +E M RE+E+ + + L +E Q+ ++ +K+ E
Sbjct: 308 QEEQMQEQEEKMWEQEEKM-REQEEKMWRQEERLWEQEKQM-REQEQKMRDQEERMWEQD 365
Query: 1385 KEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQ 1444
+ + +KEE+ Q+ + + +Q+E ++ + +++M +EE M E+ E+M EE + +Q
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 425
Query: 1445 EGKLVMIERTPS-----WQDWK------KAWDEWKQVH------GETRKSWKA------- 1480
E K +R P W+ K K W++ +++ G+ +K W+
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 485
Query: 1481 ---WKEE----------W--EKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLK-----WEE 1520
W++E W E+R+ +++E+L + E++ +++M Q+++K++ E+
Sbjct: 486 DQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQ 545
Query: 1521 WKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRK 1580
K+ W+ + +E+ + E+++ EEE+ RE EEK Q+ E+ R QEE W + +
Sbjct: 546 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMRE-QEEKMWEQEEKM 604
Query: 1581 RARAEKKRAQEER----------------------KLAQEEEKLAQEERQLAQEERKLAQ 1618
+ + EK QEE+ K+ ++EEK+ ++E ++ ++E K+ +
Sbjct: 605 QEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMRE 664
Query: 1619 AYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEK 1678
K+ + +M + E K +EE + ++ EK+ + EK+ + +K+ + EK+ +EE
Sbjct: 665 QEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE- 723
Query: 1679 LAKKGGKLAEVKNILAQKVEELPQR 1703
+ +K ++ + K + +++ E +R
Sbjct: 724 MREKEERIRDQKEKMQERLPEHEER 748
Score = 116 bits (291), Expect = 3e-25
Identities = 113/554 (20%), Positives = 250/554 (45%), Gaps = 88/554 (15%)
Query: 1071 ESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIE 1130
E E ++ + + R Q + +K LR KK +E++ + E + E E E
Sbjct: 273 EQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMR----E 328
Query: 1131 MEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKK 1190
EE W + + K + QE+ + +D ++ +++R+K ++ +K+ +
Sbjct: 329 QEE----KMWRQEERLWEQEKQMREQEQKM-RDQEERMWEQDERLREKEERMREQEKMWE 383
Query: 1191 KHKK-------KGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWR 1243
+ +K + +E K+ EE T E+ + K+ + + W
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQ-------------------EENMWE 424
Query: 1244 DDLCRLMALRISGSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLE 1303
+ R+ + K+ E ++M WE +E K+ +
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQ---------EKMQEQEEKIWE----------QEEKIRDQ 465
Query: 1304 DLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEET 1363
+ W ++K ++ QE ++ +E +R +E ++E+ + + L +E
Sbjct: 466 EEMWG----QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEE 521
Query: 1364 QVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKE 1423
++ + +K ++ + + K+ ++++EKKT+ + K +++E ++ + +++M +E
Sbjct: 522 RM---REQKKMWQQEEKMREEKK-TQEQEKKTWDQEEK-----MREEERMREREKKMREE 572
Query: 1424 ERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKE 1483
E M E+ E+M EEK+ +QE +K W++ +++ + K W+ ++
Sbjct: 573 EEMMREQEEKMQEQEEKMREQE---------------EKMWEQEEKMQEQEEKMWEQEEK 617
Query: 1484 EWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEE 1543
WE+ +EE+K+ + E + +EE +QE ++ WE+ +++ E + +E++ + +EE
Sbjct: 618 MWEQ---EEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEE 674
Query: 1544 VTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQE---EE 1600
E+E +G+E++ + EE+ QEE W + + + EK QEE + +E ++
Sbjct: 675 KMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQ 734
Query: 1601 KLAQEERQLAQEER 1614
K +ER EER
Sbjct: 735 KEKMQERLPEHEER 748
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 200 bits (509), Expect = 1e-50
Identities = 125/483 (25%), Positives = 278/483 (57%), Gaps = 24/483 (4%)
Query: 1334 QEVIRHKEVMPR-EEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEE 1392
Q + E+ R ++Q +K R ++E + +++ ++ I + + +E +++E
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQE 341
Query: 1393 KKTFQKSPKQGRKAV---QKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLV 1449
+ ++K K R+ +KE K+ + + M ++E M + E M EEK+ + E K+
Sbjct: 342 EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 401
Query: 1450 MIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEM 1509
E+ ++ ++ ++ ++ + K W++E +++ ++EEK+ + +K+ +EE
Sbjct: 402 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE--EKIREQEEKIREQEKKMWRQEEK 459
Query: 1510 LQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQ 1569
+ E +K++ EE +Q +E+ ++ EE++ +EE+ R+ E+ +Q EE+ Q
Sbjct: 460 IHEQEKIREEEKRQ---------EQEEMWRQEEKIHEQEEIWRQKEKMHEQ--EEKIRKQ 508
Query: 1570 EEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYV----KITQ 1625
EE W + + R + EK R QEE K+ ++EEK+ ++E +EE+ Q + K +
Sbjct: 509 EEKVWRQEEKIREQEEKIREQEE-KMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQE 567
Query: 1626 DDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGK 1685
+ +M + E K ++EE + ++ EK+ ++ EK ++ +K+ K+ EK+ +EEK+ ++ K
Sbjct: 568 QEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEK 627
Query: 1686 LAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEE-LNQEEGKLVE 1744
+ E + + ++ E ++E+ + QE+++ ++ E+++ + EE W++EE + ++E K+ E
Sbjct: 628 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ-EQEETMWRQEEKIREQEKKIRE 686
Query: 1745 EKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQ 1804
+++K+ E+EE + Q EK+ E+E K+ ++EE + +++EK+ + +EKM E+E RL ++ E+
Sbjct: 687 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Query: 1805 LIE 1807
+ E
Sbjct: 747 MQE 749
Score = 196 bits (497), Expect = 4e-49
Identities = 130/542 (23%), Positives = 299/542 (55%), Gaps = 31/542 (5%)
Query: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE-EEVTLEEEVSREGEEKEQ 1559
E+L + LQE +L E ++ N+ K K ++ K + L+ E G+E +
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 276
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARA-----------EKKRAQEERKLAQEEEKLAQEERQ 1608
+ Q ++E W R+++++ E+K ++E K+ ++EEK+ ++E +
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 336
Query: 1609 LAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKK 1668
+ ++E + + K+ + + M + E K ++EE + ++ EK+ ++ E + +K +K+ +
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL 396
Query: 1669 WEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEEL 1728
EK+ E+EK+ ++ K E + I + +E Q ++ W+++E +E EE + E+
Sbjct: 397 EEKM-HEQEKIREQEEKRQEEEKI---REQEKRQEQEAKMWRQEEKIREQEEKIREQEKK 452
Query: 1729 SWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEE------TKLAQEEELLIQEKE 1782
W++EE E+ K+ EE+K+ +E+E + Q EK+ E+E K+ ++EE + +++E
Sbjct: 453 MWRQEEKIHEQEKIREEEKR--QEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Query: 1783 KLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQE 1842
K+ + +EK+ E+EE++ + E++ ++ K+ ++ E W E++ + + I ++K QE
Sbjct: 511 KVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW-REEEKMHEQEKIWEEEKRQEQE 569
Query: 1843 KKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETV 1902
K QE EK+ +++E + +E++ +++ + + K+ + + + EEK+ +++E +
Sbjct: 570 DKMWRQE-EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKI 628
Query: 1903 IKKKEKLAETEKKLVQVEDSLAKKQEKLA--QEKMKLALEKAMVQGKKRLRGELDIAKEE 1960
+++EK+ E E+ + E+ + +++EK+ +EKM+ E Q +K E I ++E
Sbjct: 629 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE 688
Query: 1961 KALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSL---EEKIL 2017
+ + + + + E++ ++ E +E + + E ++ KM + E++++E+++ L EEK+
Sbjct: 689 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Query: 2018 LH 2019
H
Sbjct: 749 EH 750
Score = 190 bits (482), Expect = 2e-47
Identities = 143/613 (23%), Positives = 317/613 (51%), Gaps = 44/613 (7%)
Query: 1262 SENLNAELVTFAQEMLVDRHPSWELFQEICPLL------KKESKVLLEDLDWDVVPPEKK 1315
S++ +L A++++ H SW+ E+ L KK++ +E+L +
Sbjct: 149 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKE------- 201
Query: 1316 PIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQA--QKKARDMLGLEETQVILKKGKKV 1373
++ E +T E ++ K +E+ Q +K+ L ++E + L++ K +
Sbjct: 202 ----RDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL 257
Query: 1374 I---FLEPGNVTMGKEISKKEEKKTFQKSPKQ--GRKAVQKERKVGKIKREMTKEERDMS 1428
+ L+ +GKE+ K Q + R Q+E K+ + + ++ + E +
Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ 317
Query: 1429 EEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEK- 1487
E+ E++ EEK+ +QE K+ E W+ +K + + + + K + + WEK
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEM-MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 376
Query: 1488 -RLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQ-----YKDE 1541
++ ++EE + + EK+ EE + E +K++ +E K+ E + + K Q+ ++ E
Sbjct: 377 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 436
Query: 1542 EEVTLEEEVSREGEEK---EQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-----R 1593
E++ +EE RE E+K +++ EQ I+EE K + EK QEE
Sbjct: 437 EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKE 496
Query: 1594 KLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
K+ ++EEK+ ++E ++ ++E K+ + KI + + +M + E K ++EE + + Q
Sbjct: 497 KMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ 556
Query: 1654 EA----EKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDW 1709
E EK ++ K+ ++ EK+ +EEK+ ++ K+ E + ++ E++ ++E+ +
Sbjct: 557 EKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIRE 616
Query: 1710 QEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETK 1769
QE+++ ++ E++ E++ +EE ++E K+ E+++K+ E+EE + Q E + +E K
Sbjct: 617 QEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEK 676
Query: 1770 LAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKN 1829
+ ++E+ + +++EK+ + +E M E+EE++ + E++ E++ K+ ++ E+ E++ +
Sbjct: 677 IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 736
Query: 1830 KMILYQKKNLAQE 1842
++ L Q++ QE
Sbjct: 737 EVRLRQQEEKMQE 749
Score = 183 bits (465), Expect = 2e-45
Identities = 148/666 (22%), Positives = 339/666 (50%), Gaps = 97/666 (14%)
Query: 1693 LAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEE 1752
L Q + + +++ D +EL +E + L ++ + +EEL ++ KL +EK +L E
Sbjct: 177 LEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL-QEKLQLVES 235
Query: 1753 EEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKL 1812
E++ E +L +E E+ KL ++++ E + LG++ + + K
Sbjct: 236 EKS-----------EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284
Query: 1813 AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK 1872
++ E W + N QE+K QE EK+ + +E + +E++ ++
Sbjct: 285 VEENELW---------------NRLNQQQEEKMWRQE-EKIQEWEEKIQEQEEKIREQEE 328
Query: 1873 QLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQ 1932
++ + + K+ +++ + EEK+ +++E + +K+EK+ E+ + + E+ + +++E + +
Sbjct: 329 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 388
Query: 1933 EKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPET 1992
++ K+ + + ++++R + + +EE+ + + KR E++ ++ +E + + E
Sbjct: 389 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQEEKIR 447
Query: 1993 SRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKL 2052
+++KM + E+++ E++ EE+ ++ + EE + Q ++
Sbjct: 448 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK----------------IHEQEEI 491
Query: 2053 AKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLS 2112
+ K+ ++ E KI K +K+ R E K+ ++E K+ + + ++ +E ++
Sbjct: 492 WRQKEKMHEQEE----------KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI- 540
Query: 2113 IEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHS 2172
++ E+ ++E+K+ +++ I +EEK E+E K+ R+
Sbjct: 541 --------------REQEEMWREEEKMHEQEK---------IWEEEKRQEQEDKMWRQE- 576
Query: 2173 EVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMES 2232
E I + EE+ +EE++ R++ ++ + +EK Q +++ +E +E E
Sbjct: 577 EKIREQEEKVWRQEEKI----------REQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 2233 LLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEK-EEEEKKKKK 2291
+ E E++ E +E+EE+ +EE++ E+EE+ +E+EE +Q EK E+EKK ++
Sbjct: 627 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIRE 686
Query: 2292 KEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEE---EEEESCSLEEEVDREKEILKKEK 2348
+E E+++E+EE+ +E+EE M E+E + EE E+EE +EE E+E+ +++
Sbjct: 687 QE---EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 743
Query: 2349 QFKLQE 2354
+ K+QE
Sbjct: 744 EEKMQE 749
Score = 172 bits (437), Expect = 3e-42
Identities = 179/688 (26%), Positives = 343/688 (49%), Gaps = 111/688 (16%)
Query: 1701 PQREQNLDWQEKE-LAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQ 1759
P+ EQ Q +E L +ELE + L+ ++ EL K+L E L +
Sbjct: 107 PEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 166
Query: 1760 REKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKR-------EQLIEKKMKL 1812
+ +L Q + +K+K ++ E++ +E + L + E+L EK KL
Sbjct: 167 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 226
Query: 1813 AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK 1872
+K + + E+ N L +K E+ L +++L ++L KE + S K
Sbjct: 227 QEKLQLVESEKSEIQLNVKELKRKL----ERAKLLLPQQQLQAEADHL--GKELQSVSAK 280
Query: 1873 QLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQ 1932
QV+ ++N++ Q EEK+ +++E K+ E E+K+ + E+ + +++EK+ +
Sbjct: 281 LQAQVEEN-ELWNRLNQQQEEKMWRQEE-------KIQEWEEKIQEQEEKIREQEEKIRE 332
Query: 1933 EKMKLALEKAMVQGKKRLRGELDIAKEEKALNLE-MKRLAEEKMRLVEGKETLSKGETPE 1991
+ + K R + E+ KEEK E M EEKMR
Sbjct: 333 Q-----------EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR--------------- 366
Query: 1992 TSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRK 2051
RQ +M ++E R+ EE + E++I +EE + K+ +++
Sbjct: 367 --RQEEMMWEKEEKMRRQ---EEMMWEKEEKIRELEEKMHEQEKIR-----------EQE 410
Query: 2052 LAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRL 2111
+ + I+++E ++ AK+ R E K+ ++E K+ + ++ ++ +E ++
Sbjct: 411 EKRQEEEKIREQEKRQEQEAKM----------WRQEEKIREQEEKIREQEKKMWRQEEKI 460
Query: 2112 SIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKH 2171
EQ K I+E + +++ E+ + E+K+ +Q ++ + +M +EEK+ ++E K+ R+
Sbjct: 461 H-EQEK--IREEEKRQEQEEMWRQEEKI-HEQEEIWRQKEKMHEQEEKIRKQEEKVWRQE 516
Query: 2172 SEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEME 2231
++ E+E I E+E ++ WR+ +EK Q +E+ EE E E
Sbjct: 517 EKI---REQEEKIREQE-----EKMWRQ----------EEKIREQ-EEMWREEEKMHEQE 557
Query: 2232 SLLDELEKQES---LSSEEEEEREEEEE--REEEEVREEEEERKEEEEGEEKQVEK--EE 2284
+ +E ++QE + +EE+ RE+EE+ R+EE++RE+EE+R+E+EE KQ EK E+
Sbjct: 558 KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617
Query: 2285 EEKKKKKKEK---KKEEVQEKEEVFEEKEEIMSEEETESLSDEE---EEEESCSLEEEVD 2338
EEK ++++EK ++E+++E+EE+ +E+EE M E+E + EE E+EE+ +EE
Sbjct: 618 EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677
Query: 2339 REKEILKKEKQFKLQEQRRKSLRGRERV 2366
RE+E +E++ K++EQ E++
Sbjct: 678 REQEKKIREQEEKIREQEEMMQEQEEKM 705
Score = 101 bits (251), Expect = 1e-20
Identities = 130/609 (21%), Positives = 267/609 (43%), Gaps = 90/609 (14%)
Query: 967 DERVRIKTLSLMAEIG-IHSRTSLLQLTQKQ-----ETFREMQQQMIGEEPLDHLLGMRA 1020
DE ++ K L ++ + S S +QL K+ E + + Q + DHL
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL----G 271
Query: 1021 TDLQILSTQVEQRLNENLT---LSHRDEKPAFSLDVSMPS-ELKSSLKPPTVSEESEVAI 1076
+LQ +S +++ ++ EN L+ + E+ + + + E K + + E+ E
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 1077 KPSKGQRRGQAGVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASV 1136
+ + RR + + + +K R + E++ K E + E E E
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE--------EKMRRQE 383
Query: 1137 YSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKG 1196
W + +L + + QEK IR++ +K+ +K++++ K++
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEK----------------IREQEEKRQEEEKIREQEKRQE 427
Query: 1197 KEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISG 1256
+EAK+ +E E+ + ++ K R I +
Sbjct: 428 QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ------------------------ 463
Query: 1257 SQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKP 1316
+ + E + + QE + H E++++ + ++E K+ ++ + V +++
Sbjct: 464 EKIREEEKRQEQEEMWRQEEKI--HEQEEIWRQKEKMHEQEEKIRKQE---EKVWRQEEK 518
Query: 1317 IFIQEGAIREDMIQGVTQ-EVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIF 1375
I QE IRE + Q E IR +E M REEE+ + E + I ++ K+
Sbjct: 519 IREQEEKIREQEEKMWRQEEKIREQEEMWREEEK----------MHEQEKIWEEEKR--- 565
Query: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMA 1435
+ M ++ K E++ +K +Q K ++E K + + +M K+E + E+ E++
Sbjct: 566 -QEQEDKMWRQEEKIREQE--EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ 622
Query: 1436 TLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETR---KSWKAWKEEWEKRLLQE 1492
EEK+ +QE K+ E Q+ K E K E + + W++ E+++ ++
Sbjct: 623 EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQ--EEKIREQ 680
Query: 1493 EEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVS- 1551
E+K+ + EK+ +EEM+QE ++ WE+ +++ E + +E++ + +EE E+EV
Sbjct: 681 EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 740
Query: 1552 REGEEKEQQ 1560
R+ EEK Q+
Sbjct: 741 RQQEEKMQE 749
Score = 50.1 bits (118), Expect = 3e-05
Identities = 62/279 (22%), Positives = 132/279 (47%), Gaps = 41/279 (14%)
Query: 2098 TKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKE 2157
T+++ AL+ + + +L+ + D + + K +L + +A + ++
Sbjct: 140 TELQMALYYSQHAVK----QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYI 195
Query: 2158 EKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQV 2217
E++T+E L+ + + DEE K K AK +K +
Sbjct: 196 EELTKERDALSLELYRNTITDEE-----------------LKEKNAKLQEK--------L 230
Query: 2218 DEVESEE-HFSEEMESLLDELEKQESLSSEEEEEREEEE-EREEEEVREEEEERKEEEEG 2275
VESE+ ++ L +LE+ + L +++ + E + +E + V + + + EE E
Sbjct: 231 QLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL 290
Query: 2276 ----EEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEE---EEE 2328
++Q EK ++++K ++ +E++QE+EE E+EE + E+E + EE E+E
Sbjct: 291 WNRLNQQQEEKMW--RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 2329 ESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVL 2367
E +EE+ EKE K +Q ++ ++ + +R +E ++
Sbjct: 349 EKMRRQEEMMWEKE-EKMRRQEEMMWEKEEKMRRQEEMM 386
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 193 bits (490), Expect = 2e-48
Identities = 113/449 (25%), Positives = 262/449 (58%), Gaps = 25/449 (5%)
Query: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE-EEVTLEEEVSREGEEKEQ 1559
E+L + LQE +L E ++ N+ K K ++ K + L+ E G+E +
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 337
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQA 1619
+ Q ++E W R+++++ E+K ++E K+ + EEK+ ++E ++ ++E K+ +
Sbjct: 338 VSAKLQAQVEENELWNRLNQQQ---EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 394
Query: 1620 YVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKL 1679
K+ + + M + E K ++EE + ++ EK+ ++ E + +K +K+ + EK+ E+EK+
Sbjct: 395 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM-HEQEKI 453
Query: 1680 AKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEE 1739
++ K E + I Q E Q ++ W+++E +E EE + EE W++EE E+
Sbjct: 454 REQEEKRQEEEKIREQ---EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQ 510
Query: 1740 GKLVEEKKKLAEEE-----------EALAWQREKLSEEETKLAQEEELLIQEKEKLAQHK 1788
K+ EE+K+ +EE E + Q+EK+ E+E K+ ++EE + +++EK+ +
Sbjct: 511 EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQE 570
Query: 1789 EKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQ 1848
EK+ E+EE++ R+ E++ E++ K+ ++ E+ I EE+T+ Q++ + ++++ + +
Sbjct: 571 EKIREQEEKVWRQEEKIREQEEKIREQEEK-IREQEEMTQE-----QEEKMGEQEEKMCE 624
Query: 1849 EKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEK 1908
++EK+ +++E + +E++ +K++ + + K+ +++ + EEK+ +++E + +++EK
Sbjct: 625 QEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 684
Query: 1909 LAETEKKLVQVEDSLAKKQEKLAQEKMKL 1937
+ E E+K+ + E+ + +++ +L Q++ K+
Sbjct: 685 MQEQEEKMRRQEEKMWEQEVRLRQQEEKM 713
Score = 187 bits (474), Expect = 2e-46
Identities = 132/550 (24%), Positives = 297/550 (54%), Gaps = 60/550 (10%)
Query: 1387 ISKKEEKKTFQKSPKQGRKAVQ-KERKVGKIKREMTKEERDMSEEVEEMAT----LEEKV 1441
IS+ + F +Q AV +++K + E+TKE +S E+ L+EK
Sbjct: 225 ISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 284
Query: 1442 VKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEK-RLLQEEEKLHQAG 1500
K + KL ++E S E + + K K + E+ +LL +++L
Sbjct: 285 AKLQEKLQLVESEKS----------------EIQLNVKELKRKLERAKLLLPQQQLQAEA 328
Query: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQ 1560
+ L E + + + + EE ++W N L+ + +E+ ++ EE++ EE +E EEK ++
Sbjct: 329 DHLGKELQSVSAKLQAQVEE-NELW-NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 386
Query: 1561 VTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAY 1620
E+ R ++E K R E+K ++E + ++EEK+ ++E + ++E K+ +
Sbjct: 387 QEEKIR--EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 1621 VKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
K+ + ++ Q E + Q+EE + ++ ++ QEA K+ ++ +K+ ++ EK+ +EEK+
Sbjct: 445 EKMHEQEKIREQEEKR--QEEEKIREQEKRQEQEA-KMWRQEEKIREQEEKIREQEEKMW 501
Query: 1681 KKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEG 1740
++ K+ E + I EE ++EQ W+++E +E EE+ E++ +EE++ ++E
Sbjct: 502 RQEEKIHEQEKIR----EEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEE 557
Query: 1741 KLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGR 1800
K+ +++K+ ++EE + Q EK+ +E K+ ++EE + +++EK+ + +E E+EE++G
Sbjct: 558 KMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGE 617
Query: 1801 KREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENL 1860
+ E++ E++ K+ ++ E+ + Q++ + +++K + +++EK+ +++E +
Sbjct: 618 QEEKMCEQEEKMQEQEEK-------------MRRQEEKIREQEKKIREQEEKIREQEEMM 664
Query: 1861 LYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVE 1920
+E++ +++ + + EEK+ +++E + +++EK+ E E +L Q E
Sbjct: 665 QEQEEKMWEQEEK--------------MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQE 710
Query: 1921 DSLAKKQEKL 1930
+ + + QE L
Sbjct: 711 EKMQEHQEHL 720
Score = 184 bits (468), Expect = 8e-46
Identities = 129/483 (26%), Positives = 264/483 (54%), Gaps = 31/483 (6%)
Query: 1351 QKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKE 1410
QKK D +EE L K + + LE T+ E K++ K +K + + +
Sbjct: 248 QKKKADRY-IEE----LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ 302
Query: 1411 RKVGKIKREMTKEERDMSEEV--EEMATLEEKVVKQEGKL-VMIERTPSWQDWKKAWDE- 1466
V ++KR++ + + + ++ E L +++ KL +E W + +E
Sbjct: 303 LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 362
Query: 1467 -WKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVW 1525
W+Q E + W+ +E E+++ ++EEK+ + EK+ +EEM+ E ++ + + +W
Sbjct: 363 MWRQE--EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 420
Query: 1526 ENMLSSK-------SKEQQYKDEEEVTLEEEVSREGEEKEQQVT----EEQRHIQEEHKW 1574
E + KE++ ++ EE E+E RE EEK Q+ +E+R QE W
Sbjct: 421 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 480
Query: 1575 ARIHRKRARAEKKRAQEERKLAQEE-----EKLAQEERQLAQEERKLAQAYVKITQDDRE 1629
+ + R + EK R QEE+ QEE EK+ +EE++ QEE + ++ + E
Sbjct: 481 RQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR---EQEE 537
Query: 1630 MAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEV 1689
+ + + K ++EE + ++ EK+ ++ EK+ + +K+ ++ EKV R+EEK+ ++ K+ E
Sbjct: 538 IWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQ 597
Query: 1690 KNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKL 1749
+ + ++ E ++E+ + QE+++ ++ E+++ E++ +EE++ ++E K+ E+++K+
Sbjct: 598 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKI 657
Query: 1750 AEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKK 1809
E+EE + Q EK+ E+E K+ ++EE + +++EK+ + +EKM E+E RL ++ E++ E +
Sbjct: 658 REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 717
Query: 1810 MKL 1812
L
Sbjct: 718 EHL 720
Score = 162 bits (409), Expect = 6e-39
Identities = 128/498 (25%), Positives = 266/498 (53%), Gaps = 64/498 (12%)
Query: 1294 LKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKK 1353
LK+++ L E L +V EK I + ++ + +++ R K ++P+++ QA+
Sbjct: 280 LKEKNAKLQEKLQ--LVESEKSEIQLN--------VKELKRKLERAKLLLPQQQLQAEA- 328
Query: 1354 ARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISK---KEEK--KTFQKSPKQGRKAVQ 1408
D LG E V K +V E N ++ K +EEK + +K +Q K +
Sbjct: 329 --DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 386
Query: 1409 KERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWK 1468
+E K+ + + +M ++E M E+ E+M EE + ++E K+ E W+ +K + +
Sbjct: 387 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM-MWEKEEKIRELEE 445
Query: 1469 QVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENM 1528
++H + + +E+ EKR QEEEK+ + ++ E +M ++++K++ +E K
Sbjct: 446 KMHEQEKI-----REQEEKR--QEEEKIREQEKRQEQEAKMWRQEEKIREQEEK------ 492
Query: 1529 LSSKSKEQQYKDEEEVTLEEEVSRE--GEEKEQQVTEEQRHIQEEHKWARIHRKRARAEK 1586
+ +E+ ++ EE++ +E++ E +E+E+ +E++ ++E W + + + EK
Sbjct: 493 -IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEK 551
Query: 1587 KRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQ 1646
R QEE K+ ++EEK+ +E ++ ++E K+ + KI + + ++ + E K ++EE +
Sbjct: 552 IRKQEE-KMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQE 610
Query: 1647 RGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQN 1706
+ EK+ ++ EK+ ++ +K+ ++ EK+ R+EEK+ ++ K+ E
Sbjct: 611 QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE------------------ 652
Query: 1707 LDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEE 1766
++E +E EE+ + EE W++EE K+ E+++K+ E+EE + Q EK+ E+
Sbjct: 653 ----QEEKIREQEEMMQEQEEKMWEQEE------KMCEQEEKMQEQEEKMRRQEEKMWEQ 702
Query: 1767 ETKLAQEEELLIQEKEKL 1784
E +L Q+EE + + +E L
Sbjct: 703 EVRLRQQEEKMQEHQEHL 720
Score = 154 bits (390), Expect = 9e-37
Identities = 128/569 (22%), Positives = 301/569 (52%), Gaps = 52/569 (9%)
Query: 1792 PEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKE 1851
PE+E++ + ++ + ++++ R + + T+ +M LY ++ K L E
Sbjct: 168 PEDEQKASHQHQEALRRELEAQVHTIRILTCQK--TELQMALYYSQHAV---KQLEGEAR 222
Query: 1852 KLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQE--KETVIKK--KE 1907
L R + L + + K K + + L + + L+ E + T+ + KE
Sbjct: 223 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 282
Query: 1908 KLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELD-IAKEEKALNLE 1966
K A+ ++KL VE ++ Q + + K KL K ++ +++L+ E D + KE ++++ +
Sbjct: 283 KNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP-QQQLQAEADHLGKELQSVSAK 341
Query: 1967 MKRLAEE-----------KMRLVEGKETLSKGETPETSRQRKMTQVEQELFER--KLSLE 2013
++ EE + ++ +E + + E ++ K+ + E+++ E+ K+ +
Sbjct: 342 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 401
Query: 2014 EKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKL-----IKKRESLSK 2068
E+++ ++ + +E + + + + R + + + + K+ + K+ I+++E +
Sbjct: 402 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 461
Query: 2069 EPAKLNKILKALQ---KLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDF 2125
E K+ + K + K+ R E K+ ++E K+ + + ++ +E ++ EQ K I+E +
Sbjct: 462 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIH-EQEK--IREEEK 518
Query: 2126 SEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIE 2185
+++ E+ + E+K+ R+Q ++ + ++ +EEK+ ++E K+ R+ + + D+EE E
Sbjct: 519 RQEQEEMWRQEEKI-REQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEK--MHDQEEKIRE 575
Query: 2186 EEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSS 2245
+EE + WR+ ++ + + +EK Q +++ +E ++E E + E E++
Sbjct: 576 QEEKV------WRQEEKIR---EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQE 626
Query: 2246 EEEEEREEEEEREEEEVREEEEERKEEEEG--EEKQVEKEEEEKKKKKKEK---KKEEVQ 2300
E+ +E+EE+ R+EE++RE+E++ +E+EE E++++ +E+EEK +++EK ++E++Q
Sbjct: 627 EKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 686
Query: 2301 EKEEVFEEKEEIMSEEETESLSDEEEEEE 2329
E+EE +EE M E+E EE+ +E
Sbjct: 687 EQEEKMRRQEEKMWEQEVRLRQQEEKMQE 715
Score = 148 bits (373), Expect = 9e-35
Identities = 128/484 (26%), Positives = 248/484 (51%), Gaps = 51/484 (10%)
Query: 1934 KMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKR--LAEEKMRLVEGK--ETLSKGET 1989
+++ AL Q KK R ++ KE AL+LE+ R + +E+++ K E L E+
Sbjct: 237 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 296
Query: 1990 PETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME-ESEIAKGKLEFTRGQ---RIF 2045
++ Q + +++++L KL L ++ L E L E +S AK + + + R+
Sbjct: 297 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 356
Query: 2046 VQGQRKLAKASRKLIKKRESLSKEPAKLN----KILKALQKLTRDERKLTQEEIKMTKMK 2101
Q + K+ + K+ + E + ++ K+ KI + +K+ R E + ++E KM + +
Sbjct: 357 QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 416
Query: 2102 RALFVKERRLSIEQSKLDIKEWDFSE-----------KRSELTKDEKKLARKQRKLANKM 2150
++ KE ++ ++ + KE E + E + E++ R+Q K +
Sbjct: 417 EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE 476
Query: 2151 RRMINKEEKMTEEESKLARKHSEVILDDE---EEGGIEEEEVIPFLKRRWRKRKEAKRGD 2207
+M +EEK+ E+E K+ + ++ +E E+ I EEE + WR+ ++ + +
Sbjct: 477 AKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE 536
Query: 2208 ---KPKEKFSSQVDEVES--------EEHFSEEMESLLDELEK----QESLSSEEEEERE 2252
+ KEK Q +++ EE ++ E + ++ EK +E + +EE+ RE
Sbjct: 537 EIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIRE 596
Query: 2253 EEEE-REEEEVREEEEER-KEEEEGEEKQVEK--EEEEKKKKKKEKKKEE---VQEKEEV 2305
+EE+ RE+EE+ +E+EE+ E+EE +Q EK E+EEK ++++EK +E+ ++E+EE
Sbjct: 597 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEK 656
Query: 2306 FEEKEEIMSEEETESLSDEE---EEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRG 2362
E+EE+M E+E + EE E+EE +EE R +E E++ +L++Q K
Sbjct: 657 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 716
Query: 2363 RERV 2366
+E +
Sbjct: 717 QEHL 720
Score = 143 bits (361), Expect = 2e-33
Identities = 143/577 (24%), Positives = 286/577 (49%), Gaps = 85/577 (14%)
Query: 1712 KELAQELEELEWDMEELSWK-EEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKL 1770
K+L E +L + + SWK EL Q + +KKK E L +R+ LS E +
Sbjct: 215 KQLEGEARDLISRLHD-SWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 273
Query: 1771 AQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSME---ELT 1827
+E L KEK A+ +EK+ QL+E ++K E +N E +L
Sbjct: 274 TITDEEL---KEKNAKLQEKL------------QLVE-----SEKSEIQLNVKELKRKLE 313
Query: 1828 KNKMILYQKKNLAQEKKNLAQEKEKL-----AQRKENLLYNKERLTHSKKQLVQVKNKLG 1882
+ K++L Q++ L E +L +E + + AQ +EN L+N+ +K Q +
Sbjct: 314 RAKLLLPQQQ-LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK--- 369
Query: 1883 MFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKA 1942
+ + EEK+ +++E + +++EK+ E E+K+ + E+ + +K+EK+ +++ ++ EK
Sbjct: 370 -----IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE-EMMWEK- 422
Query: 1943 MVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQR---KMT 1999
+ K R + E+ KEEK LE K +EK+R E K + + RQ KM
Sbjct: 423 --EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 480
Query: 2000 QVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKL 2059
+ E+++ E+ EEKI E+++ EE + Q K+ + ++
Sbjct: 481 RQEEKIREQ----EEKIREQEEKMWRQEEK----------------IHEQEKIREEEKR- 519
Query: 2060 IKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD 2119
+++E + ++ K+ + +++ R + K+ ++E K+ K + ++ +E ++ ++ K+
Sbjct: 520 -QEQEEMWRQEEKIRE----QEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR 574
Query: 2120 IKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE 2179
+E + ++ + E+K+ ++ K+ + +EEKM E+E K+ + E + + E
Sbjct: 575 EQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMC-EQEEKMQEQE 633
Query: 2180 EEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEK 2239
E+ +EE++ R++ K+ + +EK Q + ++ +E E E + E+
Sbjct: 634 EKMRRQEEKI----------REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM--CEQ 681
Query: 2240 QESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGE 2276
+E + +EE+ R +EE+ E+EVR ++E K +E E
Sbjct: 682 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 112 bits (280), Expect = 5e-24
Identities = 117/549 (21%), Positives = 257/549 (46%), Gaps = 79/549 (14%)
Query: 1090 KKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKL 1149
KK + +++ L TKERD+ + + DE E++E + KL
Sbjct: 249 KKKADRYIEEL--TKERDALSLELYRNTITDE--------ELKEKNA-----------KL 287
Query: 1150 SKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPP 1209
+ + E + K I L +K L++ ++ Q+L+ + GKE + ++ +
Sbjct: 288 QEKLQLVESE--KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 345
Query: 1210 VMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAEL 1269
V E + ++ Q + WR + +I + K+ E E
Sbjct: 346 VEENELWNRLNQQQ--------------EEKMWRQEE------KIQEWEEKIQEQ--EEK 383
Query: 1270 VTFAQEMLVDRHPSWELFQEICPLLKKESKVLL-EDLDWDV---VPPEKKPIFIQEGAIR 1325
+ +E + ++ +E+ + +KE K+ E++ W+ + +++ ++ +E IR
Sbjct: 384 IREQEEKIREQEEKMRRQEEM--MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441
Query: 1326 EDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGK 1385
E + QE IR +E E+ Q ++K R+ +E + + + ++ I + + +
Sbjct: 442 ELEEKMHEQEKIREQE----EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 497
Query: 1386 EISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQE 1445
E ++E+K ++ + + Q++ ++ + + E +E+ ++ + E++ EEK+ KQE
Sbjct: 498 EKMWRQEEKIHEQEKIREEEKRQEQEEMWR-QEEKIREQEEIWRQKEKIHEQEEKIRKQE 556
Query: 1446 GKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSP 1505
K+ W+ +K D+ +++ + K W+ E+++ ++EEK+ + EK+
Sbjct: 557 EKM--------WRQEEKMHDQEEKIREQEEKVWRQ-----EEKIREQEEKIREQEEKIRE 603
Query: 1506 EEEMLQE-DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEE 1564
+EEM QE ++K+ +E K + + +E+ + EE++ +E+ RE EEK ++ EE
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE-QEE 662
Query: 1565 QRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKIT 1624
QEE W + E+K ++E K+ ++EEK+ ++E ++ ++E +L Q K+
Sbjct: 663 MMQEQEEKMWEQ--------EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714
Query: 1625 QDDREMAQA 1633
+ + A
Sbjct: 715 EHQEHLEAA 723
Score = 50.4 bits (119), Expect = 2e-05
Identities = 44/187 (23%), Positives = 94/187 (50%), Gaps = 22/187 (11%)
Query: 2202 EAKRGDKPKEKFSSQVDEVESE--------EHFSEEMESLLDELEKQESLSSEEE---EE 2250
+ K+ D+ E+ + + D + E E E+ L ++L+ ES SE + +E
Sbjct: 248 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 307
Query: 2251 REEEEEREEEEVREEEEERKEEEEGEEKQ-------VEKEEEEKKKKKKEKKKEEVQEKE 2303
+ + ER + + +++ + + + G+E Q + EE E + ++++E++ +E
Sbjct: 308 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE 367
Query: 2304 EVFEEKEEIMSEEETESLSDEE---EEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSL 2360
E +E EE + E+E + EE E+EE +EE+ EKE K +Q ++ ++ + +
Sbjct: 368 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE-KMRRQEEMMWEKEEKM 426
Query: 2361 RGRERVL 2367
R +E ++
Sbjct: 427 RRQEEMM 433
Score = 38.1 bits (87), Expect = 0.13
Identities = 53/255 (20%), Positives = 124/255 (48%), Gaps = 25/255 (9%)
Query: 2134 KDEKKLARK-QRKLANKMRRMINKEEKMT--EEESKLARKHSEVILDDEEEGGIEEEEVI 2190
+DE+K + + Q L ++ ++ +T + E ++A +S+ + E E ++I
Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEG---EARDLI 225
Query: 2191 PFLKRRWRKRKEAKRG----DKPKEKFSSQVDEVESE-EHFSEEM--ESLLDELEKQESL 2243
L W+ E ++ K+K ++E+ E + S E+ ++ DE E +E
Sbjct: 226 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE-ELKEKN 284
Query: 2244 SSEEEEEREEEEEREEEEVREEEEERKEEEEG---EEKQVEKEEEEKKKKKKE---KKKE 2297
+ +E+ + E E+ E ++ +E +RK E ++Q++ E + K+ + K +
Sbjct: 285 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 344
Query: 2298 EVQEKE---EVFEEKEEIM--SEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKL 2352
+V+E E + +++EE M EE+ + ++ +E+E E+E ++ K +Q ++
Sbjct: 345 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 404
Query: 2353 QEQRRKSLRGRERVL 2367
++ + +R +E ++
Sbjct: 405 MWEKEEKMRRQEEMM 419
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 189 bits (479), Expect = 4e-47
Identities = 268/1295 (20%), Positives = 575/1295 (44%), Gaps = 145/1295 (11%)
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETT 1207
+L++ ++E++ + A K+ Q KA A++ K+ +++ +E V EE
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 1208 PPVMEQPVTKKVKIQGRGASG-----ISGRRSTAGDGSSWR-DDLCRLMALRISGSQTKM 1261
+Q + + ++Q S R++ A + S R ++ R++ L++ ++ +
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468
Query: 1262 --SENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFI 1319
+E L A+E + + E + + ++ ES+ +V +
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKAEA 1525
Query: 1320 QEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDM-LGLEETQVILK---KGKKVIF 1375
+ ++ +Q + + ++ +E R + ++AR + + LE Q + + K+ F
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMA 1435
E T E S +EE + ++ + Q++ + + + E +E + E
Sbjct: 1586 AEK---TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 1436 TL--EEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
L + + V Q+ L E A + ++ E R+ KA ++ +R L E+
Sbjct: 1643 RLRLQAEEVAQQKSLAQAE----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 1494 EKLHQ-------AGEKLSPEEEMLQ-EDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVT 1545
E Q A ++L+ E+E+++ + + E+ +Q+ E L+ +E ++
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-------RKLAQE 1598
LE E+++ E E + + R +E + ++R AE R +E R LA+E
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1812
Query: 1599 ---EEKLAQEE--RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
+ +LA+E+ RQ A+ ER LA+ I + R +AE +KE E+L +
Sbjct: 1813 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA----ENERLRR 1868
Query: 1654 EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE 1713
AE A +R++L E+ A+ + + ++ LA+++ ++E ++ Q ++
Sbjct: 1869 LAEDEAFQRRRLE---EQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQ 1922
Query: 1714 LAQELEELEWDMEELSWKEEELNQEEGKL---VEEKKKLAEEEEALAWQREKLSEEETKL 1770
+ +E+ L+ E+ + + EL E G++ E+ + E+ E A ++ +L+ EE +
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982
Query: 1771 AQEEELLIQE----KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL 1826
+E E +Q+ +E+ A+ ++ EE ERL K E+ + + Q+ R + +E
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 1827 TKNKMILYQKKNL--AQEKKN-----LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKN 1879
+ ++ +K + Q+K+ L QE+ L Q + + +++ VQ +
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKK-QEKLAQEKMKLA 1938
+ + + + E +E + + A EK + E A++ Q + A + K A
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 1939 LEKAMVQGKK----RLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSR 1994
+ M + KK LR + + +E L L+++ +K L E + L K E E +R
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAAR 2221
Query: 1995 QRKMTQVEQELFERKLSLEEK--------------ILLHEDRILAMEESEIAKGKLEFTR 2040
QR +QVE+ELF ++ +EE IL +D + E K K
Sbjct: 2222 QR--SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 2041 GQRIFVQGQ-----RKLAKA--------SRKLIKKRESLSKEPAKLNKILKALQ------ 2081
R+ V Q R+LA+ + K++K++ +E +L + LQ
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2339
Query: 2082 -----KLTRDERKLTQEEIKMTK-MKRALFVKERR---LSIEQSKLDIKEWDFSEKRSEL 2132
+L D+ ++ Q+ + T+ +R L + +R +S E +L ++ + S ++
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 2133 TKDEKKLARKQRKLANKMRRM-INKEEKMT---------EEESKLARKHSEVILD-DEEE 2181
+D ++ ++ ++ K+ R + +EK+T ++ A + E I + + E+
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 2182 GGIEEEEVIPFLK----RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL--- 2234
+++E + LK + ++ + + ++ F S+ D + E F E+ ++ L
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 2235 --DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
DE+ K + L E++ ++++ E+ + V EE R+ + E EE K+EE ++ +++
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Query: 2293 EKKKEE-VQEKEEVFEEKEEIMSEEETESLSDEEE 2326
+++EE + E+ + E+ +++ E+ +L+ EE
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 172 bits (436), Expect = 4e-42
Identities = 265/1216 (21%), Positives = 541/1216 (44%), Gaps = 180/1216 (14%)
Query: 1295 KKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEV-MPREEEQAQKK 1353
++E+K L + + +VV E+ + Q+ ++ IQ Q++ + E + + QA+
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443
Query: 1354 ARDMLGLEETQVILKKGKKVIFLEPGNV----------TMGKEISKKEEKKTFQKSPKQG 1403
R L +EE +++ + + G E K++ ++ ++ +Q
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 1404 RKAVQKERKVG-------KIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPS 1456
+ Q++R+ K + E +E++ + +EE+ L+ + ++ + +ER
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR-LQAEEAERRLRQAEVERARQ 1562
Query: 1457 WQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEE----KLHQAGEKLSPEE---EM 1509
Q + + +++++ A K +R LQEE +L + E+ + ++ E
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 1510 LQEDKKLKWEEW----------KQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
+E+ + + E W + E + KS Q ++++ E E R G+ +EQ
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 1560 ---------QVTEEQRHIQEEHKWARIHRK----RARAEKKRAQEERKLAQEEEKLAQEE 1606
Q E+QR + E R+ + R RAE ++ +++R+L +EE LA+ +
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE--LARLQ 1740
Query: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA 1666
R+ A +K + ++ + EM A+ EE EK Q E A + ++LA
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800
Query: 1667 KKWEKV------AREEEKLAKKGG--KLAEVKNILAQKV--------------------- 1697
++ ++ A+ + +LA++ + AE + +LA+K+
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860
Query: 1698 ---EELPQREQNLDWQEKELAQELEELEWDMEE-----LSWKEEELNQEEGKLVEE--KK 1747
E L + ++ +Q + L ++ + + D+EE + EL +++G LVE+ ++
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG-LVEDTLRQ 1919
Query: 1748 KLAEEEEALAWQ---------REKLSEEETKLAQEEELLIQEKEKL---AQHKEKMPEEE 1795
+ EEE LA + + +L E ++ E ++ KE+ A + ++ EE
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 1796 ERLGRKREQLIEKKMKLAQKRERWIN-SMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
ER R+ E+ ++K + ++ R ++EE+ + K + + + L + + + + +LA
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
Q E H+ V+ K + L Q + L Q + + E E+
Sbjct: 2040 QEAAQKRLQAEEKAHA----FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 1915 KLVQVEDSLAKKQ------EKLAQEKMKLALEKAMVQ-GKKRLRGELDIAKEEKALNLEM 1967
VQ E A+ + E+L Q + A +A Q ++LR E A++E A +
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE---AEQEAARRAQA 2152
Query: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME 2027
++ A + + + + K +T RQ+ QVEQEL +L LEE H+ +L
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRLQLEETD--HQKNLL--- 2205
Query: 2028 ESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDE 2087
+ E+ + K E T R Q + +L ++ E LSK A++ +AL +D
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQM----EELSKLKARIEAENRALILRDKDN 2261
Query: 2088 -RKLTQEEIKMTKMKRALFVKERRLSI---EQSKL-DIKEWDFSEKRS------------ 2130
++ QEE + KMK+ + + RLS+ E ++L + E D +++R+
Sbjct: 2262 TQRFLQEEAE--KMKQ-VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 2131 --ELT--KDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE 2186
E T K E +L ++Q++LA + R + ++++ ++ + + L+ E + +E
Sbjct: 2319 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 2187 EEVIPFLKRRWRKRKEAK-RGDKPKEKFSSQVDEVESEEHFSE----EMESLLDELEKQE 2241
LK R + A+ R ++ ++F Q +E+ + H +E E +L+ LE Q
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ- 2437
Query: 2242 SLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
++ + + ER E + E E E KE+ + E K ++ + EE + ++E+ +E Q
Sbjct: 2438 ------RQQSDHDAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 2302 KEEVF-EEKEEIMS-----EEETESLSD--EEEEEESCSLEEEVDREKEILKKEKQ---F 2350
++ F EK+ ++ E+E L ++E ++ L EE R+++ +++E+Q
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 2351 KLQEQRRKSLRGRERV 2366
++E RR+ E V
Sbjct: 2551 SMEEARRRQHEAEEGV 2566
Score = 154 bits (390), Expect = 9e-37
Identities = 227/999 (22%), Positives = 433/999 (43%), Gaps = 130/999 (13%)
Query: 1504 SPEEEMLQE--DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE--KEQ 1559
S E ++QE D + + E + + S+ + +EEE E++ + E E + +
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL--AQEERQLAQEERKLA 1617
E+QR + E H A+ +R E ++ +E + +EE + Q++R + +E ++L
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 1618 QAYVKITQDDREMAQAEGKF------------AQKEETLAQRG------EKLSQEAEKLA 1659
Q+ Q A+A + Q E T QRG + L AE+
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486
Query: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
++++ ++ E++ R+ + +++ + AEV+ K E RE ++ Q LE
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQR-KRQAEVELASRVKAEAEAARE------KQRALQALE 1539
Query: 1720 ELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQ 1779
EL EE + + E + V+ + A+ Q ++ S E K AQ E L +
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQE 1598
Query: 1780 EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW---INSMEELTKNKMILYQK 1836
E +AQ + EE ER +++ + + + ++ ERW N L + Q+
Sbjct: 1599 EHVAVAQ----LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 1837 KNLAQ-EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL--GMFNKILAQVEE 1893
K+LAQ E + +E E+ A+R+ R +Q ++ + +L G + LA +E
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 1894 --KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE-KAMVQGKKRL 1950
+L E E ++++ L E +L + + +K+++L E K+ E + ++ K R
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 1951 RGELDIAKEEKALNLE-----MKRLAEEKMRL-VEGKETLSKGETPETSRQRKMTQVEQE 2004
E E+ LE + LAEE RL +E + + E R+ + E+
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 2005 LFERKLSLEEKILLHEDRILAMEESEIAKGKL------EFTRGQRIFVQGQRKLAKASRK 2058
L E+ ++ E L + +A++E E +L E + +R+ Q + A +
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEI---KMTKMKRALFVKERRLSIEQ 2115
L + R++ E + K L + T +R+ +EEI K + K A E L + +
Sbjct: 1895 LAQLRKASDSELER----QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 2116 SKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM-----TEEESKLARK 2170
+ + ++ S++++EL + AR+++ A + RR EE++ EEE+ RK
Sbjct: 1951 IRSNAEDTLRSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 2171 HSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK----------------RGDKPKEKFS 2214
L++ E + EE RR R+R E + + ++ F+
Sbjct: 2006 ---AALEEVERLKAKVEEA-----RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 2215 SQVDEVESEEHFSEEMESLLDELEKQESL---SSEEEEEREEEEEREEEEVREEEEERKE 2271
Q E E ++ +E +S+LD+L + ++EE EE + ERE + R + EE +
Sbjct: 2058 VQQKEQELQQTLQQE-QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 2272 EEEGEEKQVE-------------KEEEEKKKKKKEKKKEEVQEK--------------EE 2304
++ E+Q + KE E++ ++ + ++ +++K E+
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK-EILKKEKQFKLQEQRRKSLRGR 2363
+K ++ E T L EE + + L+EE+ R K E + +Q E+ S+R +
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
LS L+ + RA+ L + + L A +MK+
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Score = 122 bits (305), Expect = 7e-27
Identities = 196/962 (20%), Positives = 399/962 (41%), Gaps = 153/962 (15%)
Query: 1536 QQYKDEEEVTLEEEVSREGEEKEQ------QVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589
QQ E +V +E R + E+ Q QR +++ + R +R+ A
Sbjct: 1164 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1223
Query: 1590 QEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE 1649
Q+ R+ ++ + + + Q +E+ + QA + E + + GE
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALL--------------------EEIERHGE 1263
Query: 1650 KLSQEAEKLAQKRKKLAKKWE------KVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
K+ +E ++ A++ K +E K E K K+ + Q+ +L
Sbjct: 1264 KV-EECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 1704 EQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQRE-- 1761
L + + + E MEE EE L +++ EE+++LAE E AL QR+
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEE----EERLAEQQR--AEERERLAEVEAALEKQRQLA 1376
Query: 1762 -------KLSEEETKLAQ---EEELLIQEKEKL--AQHKEKMPEEEERLGRKREQLIEKK 1809
+E E K Q +EE++ +E+ + Q K + EE ++L + E I+ K
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
+ A+ ER +EE + +++ Q + +++ E + L R E K +
Sbjct: 1437 ARQAEAAERSRLRIEE--EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 1870 SKKQL-VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS--LAKK 1926
++L QV+++ + ++ ++ E E +K+ L E+ +Q E++ ++
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 1927 QEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSK 1986
E ++++ALE A + L+ + + EK LE + L EE + + + +E +
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSK-RASFAEKTAQLE-RSLQEEHVAVAQLREEAER 1612
Query: 1987 GETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046
+ +R + E+EL +L E + L ++ +A+ + E + +
Sbjct: 1613 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--E 1670
Query: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKI--------LKALQKLTR---------DERK 2089
+ R+ KA + +++RE +E K ++ L A Q+L R +R+
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 2090 LTQEEI-KMTKMKRALFVKERRLSIEQSK--------LDIKEWDFSEKRSELTKDEKKL- 2139
L +EE+ ++ + A K + L E +K L K E RS K +++L
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790
Query: 2140 --ARKQRKLANKMRRM------INKEEKMTEEESKLARKHSEVILDD------------- 2178
A + R+LA + R+ ++ ++ EE++ R +E +L +
Sbjct: 1791 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850
Query: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELE 2238
E E ++E+E R R+ E + + + + + + + EE ++ ++ ELE
Sbjct: 1851 EAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 2239 KQESLSSEEEEEREEEEE--------------------------REEEEVREEEEERKEE 2272
+Q+ L + +R + EE R E +E+ E
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967
Query: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE--------EETESLSDE 2324
E ++Q+ EEE ++++ +E+ ++ + +EE +++ + E EE L +
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2027
Query: 2325 EEEEESCSL---EEEVDREKEILKKEKQFKLQEQR---RKSLRGRERVLSILRGVPHGKG 2378
E+E + L +E + + +K F +Q++ +++L+ + VL LRG
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 2379 RA 2380
RA
Sbjct: 2088 RA 2089
Score = 54.7 bits (130), Expect = 1e-06
Identities = 115/578 (19%), Positives = 227/578 (39%), Gaps = 88/578 (15%)
Query: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
+L +KE + +++AE +K +VE L K +L+ E K+ LR E
Sbjct: 1008 RLPLDKEPARECAQRIAEQQKAQAEVE-GLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1066
Query: 1954 LDIA-------KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
L++ + A+ LE + +R +G E + + + + + EL
Sbjct: 1067 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1126
Query: 2007 ERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRG-QRIFVQGQRKLAKASRKLIKKRES 2065
K SL++ R A + + RG Q + + Q++ + ++ + RE
Sbjct: 1127 ATKASLKKL------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180
Query: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD-IKEWD 2124
++ Q L R + L Q +++ ++++ R+L + D + W
Sbjct: 1181 VA-------------QLLERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWL 1223
Query: 2125 FSEKRSE-----LTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE 2179
+R + + + + R+Q + + I + + EE + A+++ I D E
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283
Query: 2180 EEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQV---DEVESEEHFSEEMESLLDE 2236
+ + ++ P A KPK + S+ + V+ H+SE L
Sbjct: 1284 LQLVTYKAQLEPV----------ASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTT 1328
Query: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
L Q E R EEEER E++ EE++ E E +K+++ +
Sbjct: 1329 LTSQYIKFISETLRRMEEEER-----------LAEQQRAEERERLAEVEAALEKQRQLAE 1377
Query: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEE----EEEESCSLEEEVDR-----EKEILKKE 2347
Q K + E +E+ + E + EE +++ S++EE+ + E EI K
Sbjct: 1378 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1437
Query: 2348 KQFKLQEQRRKSLRGRERVLSI-------LRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
+Q + E+ R + RV+ + RG G+ +A+R ++ +K A E
Sbjct: 1438 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK--RQAQEE 1495
Query: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKERE 2438
E+ V ++ + K+ VE+ + + RE
Sbjct: 1496 AERLRRQVQDES---QRKRQAEVELASRVKAEAEAARE 1530
Score = 38.5 bits (88), Expect = 0.097
Identities = 117/632 (18%), Positives = 251/632 (39%), Gaps = 128/632 (20%)
Query: 979 AEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENL 1038
AE+ H + + L QK + +E+ + E DH + +LQ L + + +
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 1039 TLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLR 1098
+ E+ FS+ V M E S LK +E + ++ K ++Q++L
Sbjct: 2225 QV----EEELFSVRVQM--EELSKLKARIEAENRALILRD-----------KDNTQRFL- 2266
Query: 1099 GLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEK 1158
+ + KQ++ E L + A ++ E + Q + + ++K
Sbjct: 2267 ---QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------- 2313
Query: 1159 DISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKK 1218
+++Q +++ KA A+ L+++ + ++A+ + E+ ++ + ++
Sbjct: 2314 -----------EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQ 2356
Query: 1219 VKIQGRG-ASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEML 1277
+ + +G + R + S+ + L +L +S +Q + E+ AQ
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMSRAQARAEED--------AQRF- 2406
Query: 1278 VDRHPSWELFQEI--CPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQE 1335
R + E+ +++ L +E L++ L+ I Q+ + ++ E
Sbjct: 2407 --RKQAEEIGEKLHRTELATQEKVTLVQTLE----------IQRQQSDHDAERLREAIAE 2454
Query: 1336 VIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKT 1395
+ R KE + +E + Q K+ +M +++ Q++ + T + S EK +
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-------------TQALQQSFLSEKDS 2501
Query: 1396 FQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455
+Q+ER I++E K E+ +EV + L E+ +Q+
Sbjct: 2502 L----------LQRER---FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---------- 2538
Query: 1456 SWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKK 1515
Q + R+ A EE +R + EE + + E+L E+ ++ ++
Sbjct: 2539 -------------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2585
Query: 1516 LKWEEWKQVWENM-LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTE-EQRHIQEEHK 1573
L EE +++ E + L + EEVT + + + + + + EH
Sbjct: 2586 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645
Query: 1574 WARIHRKRARAEKKRAQEERKLAQEE-EKLAQ 1604
+ + RK +R QE L+ EE ++LAQ
Sbjct: 2646 FDGLRRK---VSAQRLQEAGILSAEELQRLAQ 2674
Score = 35.0 bits (79), Expect = 1.1
Identities = 95/488 (19%), Positives = 188/488 (38%), Gaps = 76/488 (15%)
Query: 1407 VQKERKVGKIKREMTKEERDMS-------EEVEEMATLEEKVVKQEGKLV-MIERTPSWQ 1458
V ++ + + + + ERD+ E+V+ E+ ++ L + R P Q
Sbjct: 210 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 269
Query: 1459 DWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG--EKLSPEEEMLQEDKKL 1516
D +A E + W+ ++E LL + + H A E+ P E+ ++
Sbjct: 270 DGVRA--------NELQLRWQEYREL--VLLLLQWMRHHTAAFEERRFPSSF---EEIEI 316
Query: 1517 KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWAR 1576
W ++ + E L +K ++ +LE V + + +V + E +W +
Sbjct: 317 LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAV----QAGQLKVPPGYHPLDVEKEWGK 372
Query: 1577 IHRKRARAEKK-RAQEER---------KLAQE----EEKLAQEERQLAQEERKLAQAYV- 1621
+H EK+ R++ ER KL E EE+L Q + L + R LA V
Sbjct: 373 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 432
Query: 1622 -KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
+ + +R++ +A+ + + + E++ ++ +L ++ + R E L
Sbjct: 433 QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI-RTEYNLR 491
Query: 1681 KKGGKLA---EVKNILAQKVEELPQREQN--------LDWQEKELAQELEELEWDMEELS 1729
K G A +V + Q V+ P+ E + L W E E ++ EW + +L
Sbjct: 492 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE-ENQHRVDGAEWGV-DLP 549
Query: 1730 WKEEELNQEEG--KLVEEKKKLAEEEEALAWQRE------------KLSEEETKLAQEEE 1775
E +L G + +EE + E + Q +L + KL +
Sbjct: 550 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 609
Query: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLI-----EKKMKLAQKRERWINSMEELTKNK 1830
++ E L +E L K E+ + ++ + K+E + M EL +
Sbjct: 610 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 669
Query: 1831 MILYQKKN 1838
+ + +N
Sbjct: 670 KKIKELQN 677
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 189 bits (479), Expect = 4e-47
Identities = 268/1295 (20%), Positives = 575/1295 (44%), Gaps = 145/1295 (11%)
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETT 1207
+L++ ++E++ + A K+ Q KA A++ K+ +++ +E V EE
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412
Query: 1208 PPVMEQPVTKKVKIQGRGASG-----ISGRRSTAGDGSSWR-DDLCRLMALRISGSQTKM 1261
+Q + + ++Q S R++ A + S R ++ R++ L++ ++ +
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472
Query: 1262 --SENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFI 1319
+E L A+E + + E + + ++ ES+ +V +
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKAEA 1529
Query: 1320 QEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDM-LGLEETQVILK---KGKKVIF 1375
+ ++ +Q + + ++ +E R + ++AR + + LE Q + + K+ F
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589
Query: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMA 1435
E T E S +EE + ++ + Q++ + + + E +E + E
Sbjct: 1590 AEK---TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646
Query: 1436 TL--EEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
L + + V Q+ L E A + ++ E R+ KA ++ +R L E+
Sbjct: 1647 RLRLQAEEVAQQKSLAQAE----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Query: 1494 EKLHQ-------AGEKLSPEEEMLQ-EDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVT 1545
E Q A ++L+ E+E+++ + + E+ +Q+ E L+ +E ++
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756
Query: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-------RKLAQE 1598
LE E+++ E E + + R +E + ++R AE R +E R LA+E
Sbjct: 1757 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1816
Query: 1599 ---EEKLAQEE--RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
+ +LA+E+ RQ A+ ER LA+ I + R +AE +KE E+L +
Sbjct: 1817 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA----ENERLRR 1872
Query: 1654 EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE 1713
AE A +R++L E+ A+ + + ++ LA+++ ++E ++ Q ++
Sbjct: 1873 LAEDEAFQRRRLE---EQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQ 1926
Query: 1714 LAQELEELEWDMEELSWKEEELNQEEGKL---VEEKKKLAEEEEALAWQREKLSEEETKL 1770
+ +E+ L+ E+ + + EL E G++ E+ + E+ E A ++ +L+ EE +
Sbjct: 1927 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1986
Query: 1771 AQEEELLIQE----KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL 1826
+E E +Q+ +E+ A+ ++ EE ERL K E+ + + Q+ R + +E
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046
Query: 1827 TKNKMILYQKKNL--AQEKKN-----LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKN 1879
+ ++ +K + Q+K+ L QE+ L Q + + +++ VQ +
Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2106
Query: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKK-QEKLAQEKMKLA 1938
+ + + + E +E + + A EK + E A++ Q + A + K A
Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2166
Query: 1939 LEKAMVQGKK----RLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSR 1994
+ M + KK LR + + +E L L+++ +K L E + L K E E +R
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAAR 2225
Query: 1995 QRKMTQVEQELFERKLSLEEK--------------ILLHEDRILAMEESEIAKGKLEFTR 2040
QR +QVE+ELF ++ +EE IL +D + E K K
Sbjct: 2226 QR--SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283
Query: 2041 GQRIFVQGQ-----RKLAKA--------SRKLIKKRESLSKEPAKLNKILKALQ------ 2081
R+ V Q R+LA+ + K++K++ +E +L + LQ
Sbjct: 2284 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2343
Query: 2082 -----KLTRDERKLTQEEIKMTK-MKRALFVKERR---LSIEQSKLDIKEWDFSEKRSEL 2132
+L D+ ++ Q+ + T+ +R L + +R +S E +L ++ + S ++
Sbjct: 2344 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2403
Query: 2133 TKDEKKLARKQRKLANKMRRM-INKEEKMT---------EEESKLARKHSEVILD-DEEE 2181
+D ++ ++ ++ K+ R + +EK+T ++ A + E I + + E+
Sbjct: 2404 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2463
Query: 2182 GGIEEEEVIPFLK----RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL--- 2234
+++E + LK + ++ + + ++ F S+ D + E F E+ ++ L
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2523
Query: 2235 --DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
DE+ K + L E++ ++++ E+ + V EE R+ + E EE K+EE ++ +++
Sbjct: 2524 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2583
Query: 2293 EKKKEE-VQEKEEVFEEKEEIMSEEETESLSDEEE 2326
+++EE + E+ + E+ +++ E+ +L+ EE
Sbjct: 2584 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2618
Score = 172 bits (436), Expect = 4e-42
Identities = 265/1216 (21%), Positives = 541/1216 (44%), Gaps = 180/1216 (14%)
Query: 1295 KKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEV-MPREEEQAQKK 1353
++E+K L + + +VV E+ + Q+ ++ IQ Q++ + E + + QA+
Sbjct: 1391 EREAKELQQRMQEEVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAEIQAKARQAEAA 1447
Query: 1354 ARDMLGLEETQVILKKGKKVIFLEPGNV----------TMGKEISKKEEKKTFQKSPKQG 1403
R L +EE +++ + + G E K++ ++ ++ +Q
Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1507
Query: 1404 RKAVQKERKVG-------KIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPS 1456
+ Q++R+ K + E +E++ + +EE+ L+ + ++ + +ER
Sbjct: 1508 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR-LQAEEAERRLRQAEVERARQ 1566
Query: 1457 WQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEE----KLHQAGEKLSPEE---EM 1509
Q + + +++++ A K +R LQEE +L + E+ + ++ E
Sbjct: 1567 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1626
Query: 1510 LQEDKKLKWEEW----------KQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
+E+ + + E W + E + KS Q ++++ E E R G+ +EQ
Sbjct: 1627 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1686
Query: 1560 ---------QVTEEQRHIQEEHKWARIHRK----RARAEKKRAQEERKLAQEEEKLAQEE 1606
Q E+QR + E R+ + R RAE ++ +++R+L +EE LA+ +
Sbjct: 1687 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE--LARLQ 1744
Query: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA 1666
R+ A +K + ++ + EM A+ EE EK Q E A + ++LA
Sbjct: 1745 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1804
Query: 1667 KKWEKV------AREEEKLAKKGG--KLAEVKNILAQKV--------------------- 1697
++ ++ A+ + +LA++ + AE + +LA+K+
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1864
Query: 1698 ---EELPQREQNLDWQEKELAQELEELEWDMEE-----LSWKEEELNQEEGKLVEE--KK 1747
E L + ++ +Q + L ++ + + D+EE + EL +++G LVE+ ++
Sbjct: 1865 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG-LVEDTLRQ 1923
Query: 1748 KLAEEEEALAWQ---------REKLSEEETKLAQEEELLIQEKEKL---AQHKEKMPEEE 1795
+ EEE LA + + +L E ++ E ++ KE+ A + ++ EE
Sbjct: 1924 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1983
Query: 1796 ERLGRKREQLIEKKMKLAQKRERWIN-SMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
ER R+ E+ ++K + ++ R ++EE+ + K + + + L + + + + +LA
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043
Query: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
Q E H+ V+ K + L Q + L Q + + E E+
Sbjct: 2044 QEAAQKRLQAEEKAHA----FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099
Query: 1915 KLVQVEDSLAKKQ------EKLAQEKMKLALEKAMVQ-GKKRLRGELDIAKEEKALNLEM 1967
VQ E A+ + E+L Q + A +A Q ++LR E A++E A +
Sbjct: 2100 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE---AEQEAARRAQA 2156
Query: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME 2027
++ A + + + + K +T RQ+ QVEQEL +L LEE H+ +L
Sbjct: 2157 EQAALRQKQAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRLQLEETD--HQKNLL--- 2209
Query: 2028 ESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDE 2087
+ E+ + K E T R Q + +L ++ E LSK A++ +AL +D
Sbjct: 2210 DEELQRLKAEATEAARQRSQVEEELFSVRVQM----EELSKLKARIEAENRALILRDKDN 2265
Query: 2088 -RKLTQEEIKMTKMKRALFVKERRLSI---EQSKL-DIKEWDFSEKRS------------ 2130
++ QEE + KMK+ + + RLS+ E ++L + E D +++R+
Sbjct: 2266 TQRFLQEEAE--KMKQ-VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2322
Query: 2131 --ELT--KDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE 2186
E T K E +L ++Q++LA + R + ++++ ++ + + L+ E + +E
Sbjct: 2323 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382
Query: 2187 EEVIPFLKRRWRKRKEAK-RGDKPKEKFSSQVDEVESEEHFSE----EMESLLDELEKQE 2241
LK R + A+ R ++ ++F Q +E+ + H +E E +L+ LE Q
Sbjct: 2383 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ- 2441
Query: 2242 SLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
++ + + ER E + E E E KE+ + E K ++ + EE + ++E+ +E Q
Sbjct: 2442 ------RQQSDHDAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494
Query: 2302 KEEVF-EEKEEIMS-----EEETESLSD--EEEEEESCSLEEEVDREKEILKKEKQ---F 2350
++ F EK+ ++ E+E L ++E ++ L EE R+++ +++E+Q
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554
Query: 2351 KLQEQRRKSLRGRERV 2366
++E RR+ E V
Sbjct: 2555 SMEEARRRQHEAEEGV 2570
Score = 154 bits (390), Expect = 9e-37
Identities = 227/999 (22%), Positives = 433/999 (43%), Gaps = 130/999 (13%)
Query: 1504 SPEEEMLQE--DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE--KEQ 1559
S E ++QE D + + E + + S+ + +EEE E++ + E E + +
Sbjct: 1311 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1370
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL--AQEERQLAQEERKLA 1617
E+QR + E H A+ +R E ++ +E + +EE + Q++R + +E ++L
Sbjct: 1371 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1430
Query: 1618 QAYVKITQDDREMAQAEGKF------------AQKEETLAQRG------EKLSQEAEKLA 1659
Q+ Q A+A + Q E T QRG + L AE+
Sbjct: 1431 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1490
Query: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
++++ ++ E++ R+ + +++ + AEV+ K E RE ++ Q LE
Sbjct: 1491 AQKRQAQEEAERLRRQVQDESQR-KRQAEVELASRVKAEAEAARE------KQRALQALE 1543
Query: 1720 ELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQ 1779
EL EE + + E + V+ + A+ Q ++ S E K AQ E L +
Sbjct: 1544 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQE 1602
Query: 1780 EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW---INSMEELTKNKMILYQK 1836
E +AQ + EE ER +++ + + + ++ ERW N L + Q+
Sbjct: 1603 EHVAVAQ----LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 1837 KNLAQ-EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL--GMFNKILAQVEE 1893
K+LAQ E + +E E+ A+R+ R +Q ++ + +L G + LA +E
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Query: 1894 --KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE-KAMVQGKKRL 1950
+L E E ++++ L E +L + + +K+++L E K+ E + ++ K R
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1778
Query: 1951 RGELDIAKEEKALNLE-----MKRLAEEKMRL-VEGKETLSKGETPETSRQRKMTQVEQE 2004
E E+ LE + LAEE RL +E + + E R+ + E+
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 2005 LFERKLSLEEKILLHEDRILAMEESEIAKGKL------EFTRGQRIFVQGQRKLAKASRK 2058
L E+ ++ E L + +A++E E +L E + +R+ Q + A +
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898
Query: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEI---KMTKMKRALFVKERRLSIEQ 2115
L + R++ E + K L + T +R+ +EEI K + K A E L + +
Sbjct: 1899 LAQLRKASDSELER----QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954
Query: 2116 SKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM-----TEEESKLARK 2170
+ + ++ S++++EL + AR+++ A + RR EE++ EEE+ RK
Sbjct: 1955 IRSNAEDTLRSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2009
Query: 2171 HSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK----------------RGDKPKEKFS 2214
L++ E + EE RR R+R E + + ++ F+
Sbjct: 2010 ---AALEEVERLKAKVEEA-----RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061
Query: 2215 SQVDEVESEEHFSEEMESLLDELEKQESL---SSEEEEEREEEEEREEEEVREEEEERKE 2271
Q E E ++ +E +S+LD+L + ++EE EE + ERE + R + EE +
Sbjct: 2062 VQQKEQELQQTLQQE-QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2120
Query: 2272 EEEGEEKQVE-------------KEEEEKKKKKKEKKKEEVQEK--------------EE 2304
++ E+Q + KE E++ ++ + ++ +++K E+
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK-EILKKEKQFKLQEQRRKSLRGR 2363
+K ++ E T L EE + + L+EE+ R K E + +Q E+ S+R +
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
LS L+ + RA+ L + + L A +MK+
Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2279
Score = 122 bits (305), Expect = 7e-27
Identities = 196/962 (20%), Positives = 399/962 (41%), Gaps = 153/962 (15%)
Query: 1536 QQYKDEEEVTLEEEVSREGEEKEQ------QVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589
QQ E +V +E R + E+ Q QR +++ + R +R+ A
Sbjct: 1168 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1227
Query: 1590 QEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE 1649
Q+ R+ ++ + + + Q +E+ + QA + E + + GE
Sbjct: 1228 QDARRRQEQIQAMPLADSQAVREQLRQEQALL--------------------EEIERHGE 1267
Query: 1650 KLSQEAEKLAQKRKKLAKKWE------KVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
K+ +E ++ A++ K +E K E K K+ + Q+ +L
Sbjct: 1268 KV-EECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1326
Query: 1704 EQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQRE-- 1761
L + + + E MEE EE L +++ EE+++LAE E AL QR+
Sbjct: 1327 YSELTTLTSQYIKFISETLRRMEE----EERLAEQQR--AEERERLAEVEAALEKQRQLA 1380
Query: 1762 -------KLSEEETKLAQ---EEELLIQEKEKL--AQHKEKMPEEEERLGRKREQLIEKK 1809
+E E K Q +EE++ +E+ + Q K + EE ++L + E I+ K
Sbjct: 1381 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1440
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
+ A+ ER +EE + +++ Q + +++ E + L R E K +
Sbjct: 1441 ARQAEAAERSRLRIEE--EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1498
Query: 1870 SKKQL-VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS--LAKK 1926
++L QV+++ + ++ ++ E E +K+ L E+ +Q E++ ++
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1558
Query: 1927 QEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSK 1986
E ++++ALE A + L+ + + EK LE + L EE + + + +E +
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSK-RASFAEKTAQLE-RSLQEEHVAVAQLREEAER 1616
Query: 1987 GETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046
+ +R + E+EL +L E + L ++ +A+ + E + +
Sbjct: 1617 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--E 1674
Query: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKI--------LKALQKLTR---------DERK 2089
+ R+ KA + +++RE +E K ++ L A Q+L R +R+
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734
Query: 2090 LTQEEI-KMTKMKRALFVKERRLSIEQSK--------LDIKEWDFSEKRSELTKDEKKL- 2139
L +EE+ ++ + A K + L E +K L K E RS K +++L
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1794
Query: 2140 --ARKQRKLANKMRRM------INKEEKMTEEESKLARKHSEVILDD------------- 2178
A + R+LA + R+ ++ ++ EE++ R +E +L +
Sbjct: 1795 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1854
Query: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELE 2238
E E ++E+E R R+ E + + + + + + + EE ++ ++ ELE
Sbjct: 1855 EAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1911
Query: 2239 KQESLSSEEEEEREEEEE--------------------------REEEEVREEEEERKEE 2272
+Q+ L + +R + EE R E +E+ E
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1971
Query: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE--------EETESLSDE 2324
E ++Q+ EEE ++++ +E+ ++ + +EE +++ + E EE L +
Sbjct: 1972 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2031
Query: 2325 EEEEESCSL---EEEVDREKEILKKEKQFKLQEQR---RKSLRGRERVLSILRGVPHGKG 2378
E+E + L +E + + +K F +Q++ +++L+ + VL LRG
Sbjct: 2032 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2091
Query: 2379 RA 2380
RA
Sbjct: 2092 RA 2093
Score = 54.7 bits (130), Expect = 1e-06
Identities = 115/578 (19%), Positives = 227/578 (39%), Gaps = 88/578 (15%)
Query: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
+L +KE + +++AE +K +VE L K +L+ E K+ LR E
Sbjct: 1012 RLPLDKEPARECAQRIAEQQKAQAEVE-GLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1070
Query: 1954 LDIA-------KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
L++ + A+ LE + +R +G E + + + + + EL
Sbjct: 1071 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1130
Query: 2007 ERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRG-QRIFVQGQRKLAKASRKLIKKRES 2065
K SL++ R A + + RG Q + + Q++ + ++ + RE
Sbjct: 1131 ATKASLKKL------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1184
Query: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD-IKEWD 2124
++ Q L R + L Q +++ ++++ R+L + D + W
Sbjct: 1185 VA-------------QLLERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWL 1227
Query: 2125 FSEKRSE-----LTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE 2179
+R + + + + R+Q + + I + + EE + A+++ I D E
Sbjct: 1228 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1287
Query: 2180 EEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQV---DEVESEEHFSEEMESLLDE 2236
+ + ++ P A KPK + S+ + V+ H+SE L
Sbjct: 1288 LQLVTYKAQLEPV----------ASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTT 1332
Query: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
L Q E R EEEER E++ EE++ E E +K+++ +
Sbjct: 1333 LTSQYIKFISETLRRMEEEER-----------LAEQQRAEERERLAEVEAALEKQRQLAE 1381
Query: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEE----EEEESCSLEEEVDR-----EKEILKKE 2347
Q K + E +E+ + E + EE +++ S++EE+ + E EI K
Sbjct: 1382 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1441
Query: 2348 KQFKLQEQRRKSLRGRERVLSI-------LRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
+Q + E+ R + RV+ + RG G+ +A+R ++ +K A E
Sbjct: 1442 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK--RQAQEE 1499
Query: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKERE 2438
E+ V ++ + K+ VE+ + + RE
Sbjct: 1500 AERLRRQVQDES---QRKRQAEVELASRVKAEAEAARE 1534
Score = 38.5 bits (88), Expect = 0.097
Identities = 117/632 (18%), Positives = 251/632 (39%), Gaps = 128/632 (20%)
Query: 979 AEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENL 1038
AE+ H + + L QK + +E+ + E DH + +LQ L + + +
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228
Query: 1039 TLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLR 1098
+ E+ FS+ V M E S LK +E + ++ K ++Q++L
Sbjct: 2229 QV----EEELFSVRVQM--EELSKLKARIEAENRALILRD-----------KDNTQRFL- 2270
Query: 1099 GLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEK 1158
+ + KQ++ E L + A ++ E + Q + + ++K
Sbjct: 2271 ---QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------- 2317
Query: 1159 DISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKK 1218
+++Q +++ KA A+ L+++ + ++A+ + E+ ++ + ++
Sbjct: 2318 -----------EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQ 2360
Query: 1219 VKIQGRG-ASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEML 1277
+ + +G + R + S+ + L +L +S +Q + E+ AQ
Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMSRAQARAEED--------AQRF- 2410
Query: 1278 VDRHPSWELFQEI--CPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQE 1335
R + E+ +++ L +E L++ L+ I Q+ + ++ E
Sbjct: 2411 --RKQAEEIGEKLHRTELATQEKVTLVQTLE----------IQRQQSDHDAERLREAIAE 2458
Query: 1336 VIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKT 1395
+ R KE + +E + Q K+ +M +++ Q++ + T + S EK +
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-------------TQALQQSFLSEKDS 2505
Query: 1396 FQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455
+Q+ER I++E K E+ +EV + L E+ +Q+
Sbjct: 2506 L----------LQRER---FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---------- 2542
Query: 1456 SWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKK 1515
Q + R+ A EE +R + EE + + E+L E+ ++ ++
Sbjct: 2543 -------------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2589
Query: 1516 LKWEEWKQVWENM-LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTE-EQRHIQEEHK 1573
L EE +++ E + L + EEVT + + + + + + EH
Sbjct: 2590 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2649
Query: 1574 WARIHRKRARAEKKRAQEERKLAQEE-EKLAQ 1604
+ + RK +R QE L+ EE ++LAQ
Sbjct: 2650 FDGLRRK---VSAQRLQEAGILSAEELQRLAQ 2678
Score = 35.0 bits (79), Expect = 1.1
Identities = 95/488 (19%), Positives = 188/488 (38%), Gaps = 76/488 (15%)
Query: 1407 VQKERKVGKIKREMTKEERDMS-------EEVEEMATLEEKVVKQEGKLV-MIERTPSWQ 1458
V ++ + + + + ERD+ E+V+ E+ ++ L + R P Q
Sbjct: 214 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 273
Query: 1459 DWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG--EKLSPEEEMLQEDKKL 1516
D +A E + W+ ++E LL + + H A E+ P E+ ++
Sbjct: 274 DGVRA--------NELQLRWQEYREL--VLLLLQWMRHHTAAFEERRFPSSF---EEIEI 320
Query: 1517 KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWAR 1576
W ++ + E L +K ++ +LE V + + +V + E +W +
Sbjct: 321 LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAV----QAGQLKVPPGYHPLDVEKEWGK 376
Query: 1577 IHRKRARAEKK-RAQEER---------KLAQE----EEKLAQEERQLAQEERKLAQAYV- 1621
+H EK+ R++ ER KL E EE+L Q + L + R LA V
Sbjct: 377 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 436
Query: 1622 -KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
+ + +R++ +A+ + + + E++ ++ +L ++ + R E L
Sbjct: 437 QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI-RTEYNLR 495
Query: 1681 KKGGKLA---EVKNILAQKVEELPQREQN--------LDWQEKELAQELEELEWDMEELS 1729
K G A +V + Q V+ P+ E + L W E E ++ EW + +L
Sbjct: 496 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE-ENQHRVDGAEWGV-DLP 553
Query: 1730 WKEEELNQEEG--KLVEEKKKLAEEEEALAWQRE------------KLSEEETKLAQEEE 1775
E +L G + +EE + E + Q +L + KL +
Sbjct: 554 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 613
Query: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLI-----EKKMKLAQKRERWINSMEELTKNK 1830
++ E L +E L K E+ + ++ + K+E + M EL +
Sbjct: 614 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 673
Query: 1831 MILYQKKN 1838
+ + +N
Sbjct: 674 KKIKELQN 681
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 189 bits (479), Expect = 4e-47
Identities = 268/1295 (20%), Positives = 575/1295 (44%), Gaps = 145/1295 (11%)
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETT 1207
+L++ ++E++ + A K+ Q KA A++ K+ +++ +E V EE
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 1208 PPVMEQPVTKKVKIQGRGASG-----ISGRRSTAGDGSSWR-DDLCRLMALRISGSQTKM 1261
+Q + + ++Q S R++ A + S R ++ R++ L++ ++ +
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468
Query: 1262 --SENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFI 1319
+E L A+E + + E + + ++ ES+ +V +
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKAEA 1525
Query: 1320 QEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDM-LGLEETQVILK---KGKKVIF 1375
+ ++ +Q + + ++ +E R + ++AR + + LE Q + + K+ F
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMA 1435
E T E S +EE + ++ + Q++ + + + E +E + E
Sbjct: 1586 AEK---TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 1436 TL--EEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
L + + V Q+ L E A + ++ E R+ KA ++ +R L E+
Sbjct: 1643 RLRLQAEEVAQQKSLAQAE----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 1494 EKLHQ-------AGEKLSPEEEMLQ-EDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVT 1545
E Q A ++L+ E+E+++ + + E+ +Q+ E L+ +E ++
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-------RKLAQE 1598
LE E+++ E E + + R +E + ++R AE R +E R LA+E
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1812
Query: 1599 ---EEKLAQEE--RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
+ +LA+E+ RQ A+ ER LA+ I + R +AE +KE E+L +
Sbjct: 1813 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA----ENERLRR 1868
Query: 1654 EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE 1713
AE A +R++L E+ A+ + + ++ LA+++ ++E ++ Q ++
Sbjct: 1869 LAEDEAFQRRRLE---EQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQ 1922
Query: 1714 LAQELEELEWDMEELSWKEEELNQEEGKL---VEEKKKLAEEEEALAWQREKLSEEETKL 1770
+ +E+ L+ E+ + + EL E G++ E+ + E+ E A ++ +L+ EE +
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982
Query: 1771 AQEEELLIQE----KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL 1826
+E E +Q+ +E+ A+ ++ EE ERL K E+ + + Q+ R + +E
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 1827 TKNKMILYQKKNL--AQEKKN-----LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKN 1879
+ ++ +K + Q+K+ L QE+ L Q + + +++ VQ +
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKK-QEKLAQEKMKLA 1938
+ + + + E +E + + A EK + E A++ Q + A + K A
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 1939 LEKAMVQGKK----RLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSR 1994
+ M + KK LR + + +E L L+++ +K L E + L K E E +R
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAAR 2221
Query: 1995 QRKMTQVEQELFERKLSLEEK--------------ILLHEDRILAMEESEIAKGKLEFTR 2040
QR +QVE+ELF ++ +EE IL +D + E K K
Sbjct: 2222 QR--SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 2041 GQRIFVQGQ-----RKLAKA--------SRKLIKKRESLSKEPAKLNKILKALQ------ 2081
R+ V Q R+LA+ + K++K++ +E +L + LQ
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2339
Query: 2082 -----KLTRDERKLTQEEIKMTK-MKRALFVKERR---LSIEQSKLDIKEWDFSEKRSEL 2132
+L D+ ++ Q+ + T+ +R L + +R +S E +L ++ + S ++
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 2133 TKDEKKLARKQRKLANKMRRM-INKEEKMT---------EEESKLARKHSEVILD-DEEE 2181
+D ++ ++ ++ K+ R + +EK+T ++ A + E I + + E+
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 2182 GGIEEEEVIPFLK----RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL--- 2234
+++E + LK + ++ + + ++ F S+ D + E F E+ ++ L
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 2235 --DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
DE+ K + L E++ ++++ E+ + V EE R+ + E EE K+EE ++ +++
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Query: 2293 EKKKEE-VQEKEEVFEEKEEIMSEEETESLSDEEE 2326
+++EE + E+ + E+ +++ E+ +L+ EE
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 172 bits (436), Expect = 4e-42
Identities = 265/1216 (21%), Positives = 541/1216 (44%), Gaps = 180/1216 (14%)
Query: 1295 KKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEV-MPREEEQAQKK 1353
++E+K L + + +VV E+ + Q+ ++ IQ Q++ + E + + QA+
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443
Query: 1354 ARDMLGLEETQVILKKGKKVIFLEPGNV----------TMGKEISKKEEKKTFQKSPKQG 1403
R L +EE +++ + + G E K++ ++ ++ +Q
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 1404 RKAVQKERKVG-------KIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPS 1456
+ Q++R+ K + E +E++ + +EE+ L+ + ++ + +ER
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR-LQAEEAERRLRQAEVERARQ 1562
Query: 1457 WQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEE----KLHQAGEKLSPEE---EM 1509
Q + + +++++ A K +R LQEE +L + E+ + ++ E
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 1510 LQEDKKLKWEEW----------KQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
+E+ + + E W + E + KS Q ++++ E E R G+ +EQ
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 1560 ---------QVTEEQRHIQEEHKWARIHRK----RARAEKKRAQEERKLAQEEEKLAQEE 1606
Q E+QR + E R+ + R RAE ++ +++R+L +EE LA+ +
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE--LARLQ 1740
Query: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA 1666
R+ A +K + ++ + EM A+ EE EK Q E A + ++LA
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800
Query: 1667 KKWEKV------AREEEKLAKKGG--KLAEVKNILAQKV--------------------- 1697
++ ++ A+ + +LA++ + AE + +LA+K+
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860
Query: 1698 ---EELPQREQNLDWQEKELAQELEELEWDMEE-----LSWKEEELNQEEGKLVEE--KK 1747
E L + ++ +Q + L ++ + + D+EE + EL +++G LVE+ ++
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG-LVEDTLRQ 1919
Query: 1748 KLAEEEEALAWQ---------REKLSEEETKLAQEEELLIQEKEKL---AQHKEKMPEEE 1795
+ EEE LA + + +L E ++ E ++ KE+ A + ++ EE
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 1796 ERLGRKREQLIEKKMKLAQKRERWIN-SMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
ER R+ E+ ++K + ++ R ++EE+ + K + + + L + + + + +LA
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
Q E H+ V+ K + L Q + L Q + + E E+
Sbjct: 2040 QEAAQKRLQAEEKAHA----FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 1915 KLVQVEDSLAKKQ------EKLAQEKMKLALEKAMVQ-GKKRLRGELDIAKEEKALNLEM 1967
VQ E A+ + E+L Q + A +A Q ++LR E A++E A +
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE---AEQEAARRAQA 2152
Query: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME 2027
++ A + + + + K +T RQ+ QVEQEL +L LEE H+ +L
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRLQLEETD--HQKNLL--- 2205
Query: 2028 ESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDE 2087
+ E+ + K E T R Q + +L ++ E LSK A++ +AL +D
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQM----EELSKLKARIEAENRALILRDKDN 2261
Query: 2088 -RKLTQEEIKMTKMKRALFVKERRLSI---EQSKL-DIKEWDFSEKRS------------ 2130
++ QEE + KMK+ + + RLS+ E ++L + E D +++R+
Sbjct: 2262 TQRFLQEEAE--KMKQ-VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 2131 --ELT--KDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE 2186
E T K E +L ++Q++LA + R + ++++ ++ + + L+ E + +E
Sbjct: 2319 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 2187 EEVIPFLKRRWRKRKEAK-RGDKPKEKFSSQVDEVESEEHFSE----EMESLLDELEKQE 2241
LK R + A+ R ++ ++F Q +E+ + H +E E +L+ LE Q
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ- 2437
Query: 2242 SLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
++ + + ER E + E E E KE+ + E K ++ + EE + ++E+ +E Q
Sbjct: 2438 ------RQQSDHDAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 2302 KEEVF-EEKEEIMS-----EEETESLSD--EEEEEESCSLEEEVDREKEILKKEKQ---F 2350
++ F EK+ ++ E+E L ++E ++ L EE R+++ +++E+Q
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 2351 KLQEQRRKSLRGRERV 2366
++E RR+ E V
Sbjct: 2551 SMEEARRRQHEAEEGV 2566
Score = 154 bits (390), Expect = 9e-37
Identities = 227/999 (22%), Positives = 433/999 (43%), Gaps = 130/999 (13%)
Query: 1504 SPEEEMLQE--DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE--KEQ 1559
S E ++QE D + + E + + S+ + +EEE E++ + E E + +
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL--AQEERQLAQEERKLA 1617
E+QR + E H A+ +R E ++ +E + +EE + Q++R + +E ++L
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 1618 QAYVKITQDDREMAQAEGKF------------AQKEETLAQRG------EKLSQEAEKLA 1659
Q+ Q A+A + Q E T QRG + L AE+
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486
Query: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
++++ ++ E++ R+ + +++ + AEV+ K E RE ++ Q LE
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQR-KRQAEVELASRVKAEAEAARE------KQRALQALE 1539
Query: 1720 ELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQ 1779
EL EE + + E + V+ + A+ Q ++ S E K AQ E L +
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQE 1598
Query: 1780 EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW---INSMEELTKNKMILYQK 1836
E +AQ + EE ER +++ + + + ++ ERW N L + Q+
Sbjct: 1599 EHVAVAQ----LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 1837 KNLAQ-EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL--GMFNKILAQVEE 1893
K+LAQ E + +E E+ A+R+ R +Q ++ + +L G + LA +E
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 1894 --KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE-KAMVQGKKRL 1950
+L E E ++++ L E +L + + +K+++L E K+ E + ++ K R
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 1951 RGELDIAKEEKALNLE-----MKRLAEEKMRL-VEGKETLSKGETPETSRQRKMTQVEQE 2004
E E+ LE + LAEE RL +E + + E R+ + E+
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 2005 LFERKLSLEEKILLHEDRILAMEESEIAKGKL------EFTRGQRIFVQGQRKLAKASRK 2058
L E+ ++ E L + +A++E E +L E + +R+ Q + A +
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEI---KMTKMKRALFVKERRLSIEQ 2115
L + R++ E + K L + T +R+ +EEI K + K A E L + +
Sbjct: 1895 LAQLRKASDSELER----QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 2116 SKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM-----TEEESKLARK 2170
+ + ++ S++++EL + AR+++ A + RR EE++ EEE+ RK
Sbjct: 1951 IRSNAEDTLRSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 2171 HSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK----------------RGDKPKEKFS 2214
L++ E + EE RR R+R E + + ++ F+
Sbjct: 2006 ---AALEEVERLKAKVEEA-----RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 2215 SQVDEVESEEHFSEEMESLLDELEKQESL---SSEEEEEREEEEEREEEEVREEEEERKE 2271
Q E E ++ +E +S+LD+L + ++EE EE + ERE + R + EE +
Sbjct: 2058 VQQKEQELQQTLQQE-QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 2272 EEEGEEKQVE-------------KEEEEKKKKKKEKKKEEVQEK--------------EE 2304
++ E+Q + KE E++ ++ + ++ +++K E+
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK-EILKKEKQFKLQEQRRKSLRGR 2363
+K ++ E T L EE + + L+EE+ R K E + +Q E+ S+R +
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
LS L+ + RA+ L + + L A +MK+
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Score = 122 bits (305), Expect = 7e-27
Identities = 196/962 (20%), Positives = 399/962 (41%), Gaps = 153/962 (15%)
Query: 1536 QQYKDEEEVTLEEEVSREGEEKEQ------QVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589
QQ E +V +E R + E+ Q QR +++ + R +R+ A
Sbjct: 1164 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1223
Query: 1590 QEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE 1649
Q+ R+ ++ + + + Q +E+ + QA + E + + GE
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALL--------------------EEIERHGE 1263
Query: 1650 KLSQEAEKLAQKRKKLAKKWE------KVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
K+ +E ++ A++ K +E K E K K+ + Q+ +L
Sbjct: 1264 KV-EECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 1704 EQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQRE-- 1761
L + + + E MEE EE L +++ EE+++LAE E AL QR+
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEE----EERLAEQQR--AEERERLAEVEAALEKQRQLA 1376
Query: 1762 -------KLSEEETKLAQ---EEELLIQEKEKL--AQHKEKMPEEEERLGRKREQLIEKK 1809
+E E K Q +EE++ +E+ + Q K + EE ++L + E I+ K
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
+ A+ ER +EE + +++ Q + +++ E + L R E K +
Sbjct: 1437 ARQAEAAERSRLRIEE--EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 1870 SKKQL-VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS--LAKK 1926
++L QV+++ + ++ ++ E E +K+ L E+ +Q E++ ++
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 1927 QEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSK 1986
E ++++ALE A + L+ + + EK LE + L EE + + + +E +
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSK-RASFAEKTAQLE-RSLQEEHVAVAQLREEAER 1612
Query: 1987 GETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046
+ +R + E+EL +L E + L ++ +A+ + E + +
Sbjct: 1613 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--E 1670
Query: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKI--------LKALQKLTR---------DERK 2089
+ R+ KA + +++RE +E K ++ L A Q+L R +R+
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 2090 LTQEEI-KMTKMKRALFVKERRLSIEQSK--------LDIKEWDFSEKRSELTKDEKKL- 2139
L +EE+ ++ + A K + L E +K L K E RS K +++L
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790
Query: 2140 --ARKQRKLANKMRRM------INKEEKMTEEESKLARKHSEVILDD------------- 2178
A + R+LA + R+ ++ ++ EE++ R +E +L +
Sbjct: 1791 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850
Query: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELE 2238
E E ++E+E R R+ E + + + + + + + EE ++ ++ ELE
Sbjct: 1851 EAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 2239 KQESLSSEEEEEREEEEE--------------------------REEEEVREEEEERKEE 2272
+Q+ L + +R + EE R E +E+ E
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967
Query: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE--------EETESLSDE 2324
E ++Q+ EEE ++++ +E+ ++ + +EE +++ + E EE L +
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2027
Query: 2325 EEEEESCSL---EEEVDREKEILKKEKQFKLQEQR---RKSLRGRERVLSILRGVPHGKG 2378
E+E + L +E + + +K F +Q++ +++L+ + VL LRG
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 2379 RA 2380
RA
Sbjct: 2088 RA 2089
Score = 54.7 bits (130), Expect = 1e-06
Identities = 115/578 (19%), Positives = 227/578 (39%), Gaps = 88/578 (15%)
Query: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
+L +KE + +++AE +K +VE L K +L+ E K+ LR E
Sbjct: 1008 RLPLDKEPARECAQRIAEQQKAQAEVE-GLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1066
Query: 1954 LDIA-------KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
L++ + A+ LE + +R +G E + + + + + EL
Sbjct: 1067 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1126
Query: 2007 ERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRG-QRIFVQGQRKLAKASRKLIKKRES 2065
K SL++ R A + + RG Q + + Q++ + ++ + RE
Sbjct: 1127 ATKASLKKL------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180
Query: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD-IKEWD 2124
++ Q L R + L Q +++ ++++ R+L + D + W
Sbjct: 1181 VA-------------QLLERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWL 1223
Query: 2125 FSEKRSE-----LTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE 2179
+R + + + + R+Q + + I + + EE + A+++ I D E
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283
Query: 2180 EEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQV---DEVESEEHFSEEMESLLDE 2236
+ + ++ P A KPK + S+ + V+ H+SE L
Sbjct: 1284 LQLVTYKAQLEPV----------ASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTT 1328
Query: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
L Q E R EEEER E++ EE++ E E +K+++ +
Sbjct: 1329 LTSQYIKFISETLRRMEEEER-----------LAEQQRAEERERLAEVEAALEKQRQLAE 1377
Query: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEE----EEEESCSLEEEVDR-----EKEILKKE 2347
Q K + E +E+ + E + EE +++ S++EE+ + E EI K
Sbjct: 1378 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1437
Query: 2348 KQFKLQEQRRKSLRGRERVLSI-------LRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
+Q + E+ R + RV+ + RG G+ +A+R ++ +K A E
Sbjct: 1438 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK--RQAQEE 1495
Query: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKERE 2438
E+ V ++ + K+ VE+ + + RE
Sbjct: 1496 AERLRRQVQDES---QRKRQAEVELASRVKAEAEAARE 1530
Score = 38.5 bits (88), Expect = 0.097
Identities = 117/632 (18%), Positives = 251/632 (39%), Gaps = 128/632 (20%)
Query: 979 AEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENL 1038
AE+ H + + L QK + +E+ + E DH + +LQ L + + +
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 1039 TLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLR 1098
+ E+ FS+ V M E S LK +E + ++ K ++Q++L
Sbjct: 2225 QV----EEELFSVRVQM--EELSKLKARIEAENRALILRD-----------KDNTQRFL- 2266
Query: 1099 GLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEK 1158
+ + KQ++ E L + A ++ E + Q + + ++K
Sbjct: 2267 ---QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------- 2313
Query: 1159 DISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKK 1218
+++Q +++ KA A+ L+++ + ++A+ + E+ ++ + ++
Sbjct: 2314 -----------EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQ 2356
Query: 1219 VKIQGRG-ASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEML 1277
+ + +G + R + S+ + L +L +S +Q + E+ AQ
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMSRAQARAEED--------AQRF- 2406
Query: 1278 VDRHPSWELFQEI--CPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQE 1335
R + E+ +++ L +E L++ L+ I Q+ + ++ E
Sbjct: 2407 --RKQAEEIGEKLHRTELATQEKVTLVQTLE----------IQRQQSDHDAERLREAIAE 2454
Query: 1336 VIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKT 1395
+ R KE + +E + Q K+ +M +++ Q++ + T + S EK +
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-------------TQALQQSFLSEKDS 2501
Query: 1396 FQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455
+Q+ER I++E K E+ +EV + L E+ +Q+
Sbjct: 2502 L----------LQRER---FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---------- 2538
Query: 1456 SWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKK 1515
Q + R+ A EE +R + EE + + E+L E+ ++ ++
Sbjct: 2539 -------------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2585
Query: 1516 LKWEEWKQVWENM-LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTE-EQRHIQEEHK 1573
L EE +++ E + L + EEVT + + + + + + EH
Sbjct: 2586 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645
Query: 1574 WARIHRKRARAEKKRAQEERKLAQEE-EKLAQ 1604
+ + RK +R QE L+ EE ++LAQ
Sbjct: 2646 FDGLRRK---VSAQRLQEAGILSAEELQRLAQ 2674
Score = 35.0 bits (79), Expect = 1.1
Identities = 95/488 (19%), Positives = 188/488 (38%), Gaps = 76/488 (15%)
Query: 1407 VQKERKVGKIKREMTKEERDMS-------EEVEEMATLEEKVVKQEGKLV-MIERTPSWQ 1458
V ++ + + + + ERD+ E+V+ E+ ++ L + R P Q
Sbjct: 210 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 269
Query: 1459 DWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG--EKLSPEEEMLQEDKKL 1516
D +A E + W+ ++E LL + + H A E+ P E+ ++
Sbjct: 270 DGVRA--------NELQLRWQEYREL--VLLLLQWMRHHTAAFEERRFPSSF---EEIEI 316
Query: 1517 KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWAR 1576
W ++ + E L +K ++ +LE V + + +V + E +W +
Sbjct: 317 LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAV----QAGQLKVPPGYHPLDVEKEWGK 372
Query: 1577 IHRKRARAEKK-RAQEER---------KLAQE----EEKLAQEERQLAQEERKLAQAYV- 1621
+H EK+ R++ ER KL E EE+L Q + L + R LA V
Sbjct: 373 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 432
Query: 1622 -KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
+ + +R++ +A+ + + + E++ ++ +L ++ + R E L
Sbjct: 433 QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI-RTEYNLR 491
Query: 1681 KKGGKLA---EVKNILAQKVEELPQREQN--------LDWQEKELAQELEELEWDMEELS 1729
K G A +V + Q V+ P+ E + L W E E ++ EW + +L
Sbjct: 492 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE-ENQHRVDGAEWGV-DLP 549
Query: 1730 WKEEELNQEEG--KLVEEKKKLAEEEEALAWQRE------------KLSEEETKLAQEEE 1775
E +L G + +EE + E + Q +L + KL +
Sbjct: 550 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 609
Query: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLI-----EKKMKLAQKRERWINSMEELTKNK 1830
++ E L +E L K E+ + ++ + K+E + M EL +
Sbjct: 610 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 669
Query: 1831 MILYQKKN 1838
+ + +N
Sbjct: 670 KKIKELQN 677
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 189 bits (479), Expect = 4e-47
Identities = 268/1295 (20%), Positives = 575/1295 (44%), Gaps = 145/1295 (11%)
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETT 1207
+L++ ++E++ + A K+ Q KA A++ K+ +++ +E V EE
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376
Query: 1208 PPVMEQPVTKKVKIQGRGASG-----ISGRRSTAGDGSSWR-DDLCRLMALRISGSQTKM 1261
+Q + + ++Q S R++ A + S R ++ R++ L++ ++ +
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436
Query: 1262 --SENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFI 1319
+E L A+E + + E + + ++ ES+ +V +
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKAEA 1493
Query: 1320 QEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDM-LGLEETQVILK---KGKKVIF 1375
+ ++ +Q + + ++ +E R + ++AR + + LE Q + + K+ F
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553
Query: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMA 1435
E T E S +EE + ++ + Q++ + + + E +E + E
Sbjct: 1554 AEK---TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610
Query: 1436 TL--EEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
L + + V Q+ L E A + ++ E R+ KA ++ +R L E+
Sbjct: 1611 RLRLQAEEVAQQKSLAQAE----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660
Query: 1494 EKLHQ-------AGEKLSPEEEMLQ-EDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVT 1545
E Q A ++L+ E+E+++ + + E+ +Q+ E L+ +E ++
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720
Query: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-------RKLAQE 1598
LE E+++ E E + + R +E + ++R AE R +E R LA+E
Sbjct: 1721 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1780
Query: 1599 ---EEKLAQEE--RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
+ +LA+E+ RQ A+ ER LA+ I + R +AE +KE E+L +
Sbjct: 1781 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA----ENERLRR 1836
Query: 1654 EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE 1713
AE A +R++L E+ A+ + + ++ LA+++ ++E ++ Q ++
Sbjct: 1837 LAEDEAFQRRRLE---EQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQ 1890
Query: 1714 LAQELEELEWDMEELSWKEEELNQEEGKL---VEEKKKLAEEEEALAWQREKLSEEETKL 1770
+ +E+ L+ E+ + + EL E G++ E+ + E+ E A ++ +L+ EE +
Sbjct: 1891 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1950
Query: 1771 AQEEELLIQE----KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL 1826
+E E +Q+ +E+ A+ ++ EE ERL K E+ + + Q+ R + +E
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010
Query: 1827 TKNKMILYQKKNL--AQEKKN-----LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKN 1879
+ ++ +K + Q+K+ L QE+ L Q + + +++ VQ +
Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2070
Query: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKK-QEKLAQEKMKLA 1938
+ + + + E +E + + A EK + E A++ Q + A + K A
Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2130
Query: 1939 LEKAMVQGKK----RLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSR 1994
+ M + KK LR + + +E L L+++ +K L E + L K E E +R
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAAR 2189
Query: 1995 QRKMTQVEQELFERKLSLEEK--------------ILLHEDRILAMEESEIAKGKLEFTR 2040
QR +QVE+ELF ++ +EE IL +D + E K K
Sbjct: 2190 QR--SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247
Query: 2041 GQRIFVQGQ-----RKLAKA--------SRKLIKKRESLSKEPAKLNKILKALQ------ 2081
R+ V Q R+LA+ + K++K++ +E +L + LQ
Sbjct: 2248 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2307
Query: 2082 -----KLTRDERKLTQEEIKMTK-MKRALFVKERR---LSIEQSKLDIKEWDFSEKRSEL 2132
+L D+ ++ Q+ + T+ +R L + +R +S E +L ++ + S ++
Sbjct: 2308 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2367
Query: 2133 TKDEKKLARKQRKLANKMRRM-INKEEKMT---------EEESKLARKHSEVILD-DEEE 2181
+D ++ ++ ++ K+ R + +EK+T ++ A + E I + + E+
Sbjct: 2368 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2427
Query: 2182 GGIEEEEVIPFLK----RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL--- 2234
+++E + LK + ++ + + ++ F S+ D + E F E+ ++ L
Sbjct: 2428 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2487
Query: 2235 --DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
DE+ K + L E++ ++++ E+ + V EE R+ + E EE K+EE ++ +++
Sbjct: 2488 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2547
Query: 2293 EKKKEE-VQEKEEVFEEKEEIMSEEETESLSDEEE 2326
+++EE + E+ + E+ +++ E+ +L+ EE
Sbjct: 2548 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2582
Score = 172 bits (436), Expect = 4e-42
Identities = 265/1216 (21%), Positives = 541/1216 (44%), Gaps = 180/1216 (14%)
Query: 1295 KKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEV-MPREEEQAQKK 1353
++E+K L + + +VV E+ + Q+ ++ IQ Q++ + E + + QA+
Sbjct: 1355 EREAKELQQRMQEEVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAEIQAKARQAEAA 1411
Query: 1354 ARDMLGLEETQVILKKGKKVIFLEPGNV----------TMGKEISKKEEKKTFQKSPKQG 1403
R L +EE +++ + + G E K++ ++ ++ +Q
Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1471
Query: 1404 RKAVQKERKVG-------KIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPS 1456
+ Q++R+ K + E +E++ + +EE+ L+ + ++ + +ER
Sbjct: 1472 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR-LQAEEAERRLRQAEVERARQ 1530
Query: 1457 WQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEE----KLHQAGEKLSPEE---EM 1509
Q + + +++++ A K +R LQEE +L + E+ + ++ E
Sbjct: 1531 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1590
Query: 1510 LQEDKKLKWEEW----------KQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
+E+ + + E W + E + KS Q ++++ E E R G+ +EQ
Sbjct: 1591 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1650
Query: 1560 ---------QVTEEQRHIQEEHKWARIHRK----RARAEKKRAQEERKLAQEEEKLAQEE 1606
Q E+QR + E R+ + R RAE ++ +++R+L +EE LA+ +
Sbjct: 1651 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE--LARLQ 1708
Query: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA 1666
R+ A +K + ++ + EM A+ EE EK Q E A + ++LA
Sbjct: 1709 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1768
Query: 1667 KKWEKV------AREEEKLAKKGG--KLAEVKNILAQKV--------------------- 1697
++ ++ A+ + +LA++ + AE + +LA+K+
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1828
Query: 1698 ---EELPQREQNLDWQEKELAQELEELEWDMEE-----LSWKEEELNQEEGKLVEE--KK 1747
E L + ++ +Q + L ++ + + D+EE + EL +++G LVE+ ++
Sbjct: 1829 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG-LVEDTLRQ 1887
Query: 1748 KLAEEEEALAWQ---------REKLSEEETKLAQEEELLIQEKEKL---AQHKEKMPEEE 1795
+ EEE LA + + +L E ++ E ++ KE+ A + ++ EE
Sbjct: 1888 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1947
Query: 1796 ERLGRKREQLIEKKMKLAQKRERWIN-SMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
ER R+ E+ ++K + ++ R ++EE+ + K + + + L + + + + +LA
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007
Query: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
Q E H+ V+ K + L Q + L Q + + E E+
Sbjct: 2008 QEAAQKRLQAEEKAHA----FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063
Query: 1915 KLVQVEDSLAKKQ------EKLAQEKMKLALEKAMVQ-GKKRLRGELDIAKEEKALNLEM 1967
VQ E A+ + E+L Q + A +A Q ++LR E A++E A +
Sbjct: 2064 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE---AEQEAARRAQA 2120
Query: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME 2027
++ A + + + + K +T RQ+ QVEQEL +L LEE H+ +L
Sbjct: 2121 EQAALRQKQAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRLQLEETD--HQKNLL--- 2173
Query: 2028 ESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDE 2087
+ E+ + K E T R Q + +L ++ E LSK A++ +AL +D
Sbjct: 2174 DEELQRLKAEATEAARQRSQVEEELFSVRVQM----EELSKLKARIEAENRALILRDKDN 2229
Query: 2088 -RKLTQEEIKMTKMKRALFVKERRLSI---EQSKL-DIKEWDFSEKRS------------ 2130
++ QEE + KMK+ + + RLS+ E ++L + E D +++R+
Sbjct: 2230 TQRFLQEEAE--KMKQ-VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2286
Query: 2131 --ELT--KDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE 2186
E T K E +L ++Q++LA + R + ++++ ++ + + L+ E + +E
Sbjct: 2287 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346
Query: 2187 EEVIPFLKRRWRKRKEAK-RGDKPKEKFSSQVDEVESEEHFSE----EMESLLDELEKQE 2241
LK R + A+ R ++ ++F Q +E+ + H +E E +L+ LE Q
Sbjct: 2347 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ- 2405
Query: 2242 SLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
++ + + ER E + E E E KE+ + E K ++ + EE + ++E+ +E Q
Sbjct: 2406 ------RQQSDHDAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458
Query: 2302 KEEVF-EEKEEIMS-----EEETESLSD--EEEEEESCSLEEEVDREKEILKKEKQ---F 2350
++ F EK+ ++ E+E L ++E ++ L EE R+++ +++E+Q
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518
Query: 2351 KLQEQRRKSLRGRERV 2366
++E RR+ E V
Sbjct: 2519 SMEEARRRQHEAEEGV 2534
Score = 154 bits (390), Expect = 9e-37
Identities = 227/999 (22%), Positives = 433/999 (43%), Gaps = 130/999 (13%)
Query: 1504 SPEEEMLQE--DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE--KEQ 1559
S E ++QE D + + E + + S+ + +EEE E++ + E E + +
Sbjct: 1275 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1334
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL--AQEERQLAQEERKLA 1617
E+QR + E H A+ +R E ++ +E + +EE + Q++R + +E ++L
Sbjct: 1335 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1394
Query: 1618 QAYVKITQDDREMAQAEGKF------------AQKEETLAQRG------EKLSQEAEKLA 1659
Q+ Q A+A + Q E T QRG + L AE+
Sbjct: 1395 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1454
Query: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
++++ ++ E++ R+ + +++ + AEV+ K E RE ++ Q LE
Sbjct: 1455 AQKRQAQEEAERLRRQVQDESQR-KRQAEVELASRVKAEAEAARE------KQRALQALE 1507
Query: 1720 ELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQ 1779
EL EE + + E + V+ + A+ Q ++ S E K AQ E L +
Sbjct: 1508 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQE 1566
Query: 1780 EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW---INSMEELTKNKMILYQK 1836
E +AQ + EE ER +++ + + + ++ ERW N L + Q+
Sbjct: 1567 EHVAVAQ----LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 1837 KNLAQ-EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL--GMFNKILAQVEE 1893
K+LAQ E + +E E+ A+R+ R +Q ++ + +L G + LA +E
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Query: 1894 --KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE-KAMVQGKKRL 1950
+L E E ++++ L E +L + + +K+++L E K+ E + ++ K R
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1742
Query: 1951 RGELDIAKEEKALNLE-----MKRLAEEKMRL-VEGKETLSKGETPETSRQRKMTQVEQE 2004
E E+ LE + LAEE RL +E + + E R+ + E+
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802
Query: 2005 LFERKLSLEEKILLHEDRILAMEESEIAKGKL------EFTRGQRIFVQGQRKLAKASRK 2058
L E+ ++ E L + +A++E E +L E + +R+ Q + A +
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862
Query: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEI---KMTKMKRALFVKERRLSIEQ 2115
L + R++ E + K L + T +R+ +EEI K + K A E L + +
Sbjct: 1863 LAQLRKASDSELER----QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918
Query: 2116 SKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM-----TEEESKLARK 2170
+ + ++ S++++EL + AR+++ A + RR EE++ EEE+ RK
Sbjct: 1919 IRSNAEDTLRSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1973
Query: 2171 HSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK----------------RGDKPKEKFS 2214
L++ E + EE RR R+R E + + ++ F+
Sbjct: 1974 ---AALEEVERLKAKVEEA-----RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025
Query: 2215 SQVDEVESEEHFSEEMESLLDELEKQESL---SSEEEEEREEEEEREEEEVREEEEERKE 2271
Q E E ++ +E +S+LD+L + ++EE EE + ERE + R + EE +
Sbjct: 2026 VQQKEQELQQTLQQE-QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2084
Query: 2272 EEEGEEKQVE-------------KEEEEKKKKKKEKKKEEVQEK--------------EE 2304
++ E+Q + KE E++ ++ + ++ +++K E+
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK-EILKKEKQFKLQEQRRKSLRGR 2363
+K ++ E T L EE + + L+EE+ R K E + +Q E+ S+R +
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
LS L+ + RA+ L + + L A +MK+
Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2243
Score = 122 bits (305), Expect = 7e-27
Identities = 196/962 (20%), Positives = 399/962 (41%), Gaps = 153/962 (15%)
Query: 1536 QQYKDEEEVTLEEEVSREGEEKEQ------QVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589
QQ E +V +E R + E+ Q QR +++ + R +R+ A
Sbjct: 1132 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1191
Query: 1590 QEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE 1649
Q+ R+ ++ + + + Q +E+ + QA + E + + GE
Sbjct: 1192 QDARRRQEQIQAMPLADSQAVREQLRQEQALL--------------------EEIERHGE 1231
Query: 1650 KLSQEAEKLAQKRKKLAKKWE------KVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
K+ +E ++ A++ K +E K E K K+ + Q+ +L
Sbjct: 1232 KV-EECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1290
Query: 1704 EQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQRE-- 1761
L + + + E MEE EE L +++ EE+++LAE E AL QR+
Sbjct: 1291 YSELTTLTSQYIKFISETLRRMEE----EERLAEQQR--AEERERLAEVEAALEKQRQLA 1344
Query: 1762 -------KLSEEETKLAQ---EEELLIQEKEKL--AQHKEKMPEEEERLGRKREQLIEKK 1809
+E E K Q +EE++ +E+ + Q K + EE ++L + E I+ K
Sbjct: 1345 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1404
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
+ A+ ER +EE + +++ Q + +++ E + L R E K +
Sbjct: 1405 ARQAEAAERSRLRIEE--EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1462
Query: 1870 SKKQL-VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS--LAKK 1926
++L QV+++ + ++ ++ E E +K+ L E+ +Q E++ ++
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1522
Query: 1927 QEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSK 1986
E ++++ALE A + L+ + + EK LE + L EE + + + +E +
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSK-RASFAEKTAQLE-RSLQEEHVAVAQLREEAER 1580
Query: 1987 GETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046
+ +R + E+EL +L E + L ++ +A+ + E + +
Sbjct: 1581 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--E 1638
Query: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKI--------LKALQKLTR---------DERK 2089
+ R+ KA + +++RE +E K ++ L A Q+L R +R+
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698
Query: 2090 LTQEEI-KMTKMKRALFVKERRLSIEQSK--------LDIKEWDFSEKRSELTKDEKKL- 2139
L +EE+ ++ + A K + L E +K L K E RS K +++L
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1758
Query: 2140 --ARKQRKLANKMRRM------INKEEKMTEEESKLARKHSEVILDD------------- 2178
A + R+LA + R+ ++ ++ EE++ R +E +L +
Sbjct: 1759 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1818
Query: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELE 2238
E E ++E+E R R+ E + + + + + + + EE ++ ++ ELE
Sbjct: 1819 EAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1875
Query: 2239 KQESLSSEEEEEREEEEE--------------------------REEEEVREEEEERKEE 2272
+Q+ L + +R + EE R E +E+ E
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1935
Query: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE--------EETESLSDE 2324
E ++Q+ EEE ++++ +E+ ++ + +EE +++ + E EE L +
Sbjct: 1936 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 1995
Query: 2325 EEEEESCSL---EEEVDREKEILKKEKQFKLQEQR---RKSLRGRERVLSILRGVPHGKG 2378
E+E + L +E + + +K F +Q++ +++L+ + VL LRG
Sbjct: 1996 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2055
Query: 2379 RA 2380
RA
Sbjct: 2056 RA 2057
Score = 54.7 bits (130), Expect = 1e-06
Identities = 115/578 (19%), Positives = 227/578 (39%), Gaps = 88/578 (15%)
Query: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
+L +KE + +++AE +K +VE L K +L+ E K+ LR E
Sbjct: 976 RLPLDKEPARECAQRIAEQQKAQAEVE-GLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1034
Query: 1954 LDIA-------KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
L++ + A+ LE + +R +G E + + + + + EL
Sbjct: 1035 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1094
Query: 2007 ERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRG-QRIFVQGQRKLAKASRKLIKKRES 2065
K SL++ R A + + RG Q + + Q++ + ++ + RE
Sbjct: 1095 ATKASLKKL------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1148
Query: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD-IKEWD 2124
++ Q L R + L Q +++ ++++ R+L + D + W
Sbjct: 1149 VA-------------QLLERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWL 1191
Query: 2125 FSEKRSE-----LTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE 2179
+R + + + + R+Q + + I + + EE + A+++ I D E
Sbjct: 1192 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1251
Query: 2180 EEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQV---DEVESEEHFSEEMESLLDE 2236
+ + ++ P A KPK + S+ + V+ H+SE L
Sbjct: 1252 LQLVTYKAQLEPV----------ASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTT 1296
Query: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
L Q E R EEEER E++ EE++ E E +K+++ +
Sbjct: 1297 LTSQYIKFISETLRRMEEEER-----------LAEQQRAEERERLAEVEAALEKQRQLAE 1345
Query: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEE----EEEESCSLEEEVDR-----EKEILKKE 2347
Q K + E +E+ + E + EE +++ S++EE+ + E EI K
Sbjct: 1346 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1405
Query: 2348 KQFKLQEQRRKSLRGRERVLSI-------LRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
+Q + E+ R + RV+ + RG G+ +A+R ++ +K A E
Sbjct: 1406 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK--RQAQEE 1463
Query: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKERE 2438
E+ V ++ + K+ VE+ + + RE
Sbjct: 1464 AERLRRQVQDES---QRKRQAEVELASRVKAEAEAARE 1498
Score = 38.5 bits (88), Expect = 0.097
Identities = 117/632 (18%), Positives = 251/632 (39%), Gaps = 128/632 (20%)
Query: 979 AEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENL 1038
AE+ H + + L QK + +E+ + E DH + +LQ L + + +
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192
Query: 1039 TLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLR 1098
+ E+ FS+ V M E S LK +E + ++ K ++Q++L
Sbjct: 2193 QV----EEELFSVRVQM--EELSKLKARIEAENRALILRD-----------KDNTQRFL- 2234
Query: 1099 GLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEK 1158
+ + KQ++ E L + A ++ E + Q + + ++K
Sbjct: 2235 ---QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------- 2281
Query: 1159 DISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKK 1218
+++Q +++ KA A+ L+++ + ++A+ + E+ ++ + ++
Sbjct: 2282 -----------EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQ 2324
Query: 1219 VKIQGRG-ASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEML 1277
+ + +G + R + S+ + L +L +S +Q + E+ AQ
Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMSRAQARAEED--------AQRF- 2374
Query: 1278 VDRHPSWELFQEI--CPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQE 1335
R + E+ +++ L +E L++ L+ I Q+ + ++ E
Sbjct: 2375 --RKQAEEIGEKLHRTELATQEKVTLVQTLE----------IQRQQSDHDAERLREAIAE 2422
Query: 1336 VIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKT 1395
+ R KE + +E + Q K+ +M +++ Q++ + T + S EK +
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-------------TQALQQSFLSEKDS 2469
Query: 1396 FQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455
+Q+ER I++E K E+ +EV + L E+ +Q+
Sbjct: 2470 L----------LQRER---FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---------- 2506
Query: 1456 SWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKK 1515
Q + R+ A EE +R + EE + + E+L E+ ++ ++
Sbjct: 2507 -------------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2553
Query: 1516 LKWEEWKQVWENM-LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTE-EQRHIQEEHK 1573
L EE +++ E + L + EEVT + + + + + + EH
Sbjct: 2554 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2613
Query: 1574 WARIHRKRARAEKKRAQEERKLAQEE-EKLAQ 1604
+ + RK +R QE L+ EE ++LAQ
Sbjct: 2614 FDGLRRK---VSAQRLQEAGILSAEELQRLAQ 2642
Score = 35.0 bits (79), Expect = 1.1
Identities = 95/488 (19%), Positives = 188/488 (38%), Gaps = 76/488 (15%)
Query: 1407 VQKERKVGKIKREMTKEERDMS-------EEVEEMATLEEKVVKQEGKLV-MIERTPSWQ 1458
V ++ + + + + ERD+ E+V+ E+ ++ L + R P Q
Sbjct: 178 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 237
Query: 1459 DWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG--EKLSPEEEMLQEDKKL 1516
D +A E + W+ ++E LL + + H A E+ P E+ ++
Sbjct: 238 DGVRA--------NELQLRWQEYREL--VLLLLQWMRHHTAAFEERRFPSSF---EEIEI 284
Query: 1517 KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWAR 1576
W ++ + E L +K ++ +LE V + + +V + E +W +
Sbjct: 285 LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAV----QAGQLKVPPGYHPLDVEKEWGK 340
Query: 1577 IHRKRARAEKK-RAQEER---------KLAQE----EEKLAQEERQLAQEERKLAQAYV- 1621
+H EK+ R++ ER KL E EE+L Q + L + R LA V
Sbjct: 341 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 400
Query: 1622 -KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
+ + +R++ +A+ + + + E++ ++ +L ++ + R E L
Sbjct: 401 QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI-RTEYNLR 459
Query: 1681 KKGGKLA---EVKNILAQKVEELPQREQN--------LDWQEKELAQELEELEWDMEELS 1729
K G A +V + Q V+ P+ E + L W E E ++ EW + +L
Sbjct: 460 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE-ENQHRVDGAEWGV-DLP 517
Query: 1730 WKEEELNQEEG--KLVEEKKKLAEEEEALAWQRE------------KLSEEETKLAQEEE 1775
E +L G + +EE + E + Q +L + KL +
Sbjct: 518 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 577
Query: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLI-----EKKMKLAQKRERWINSMEELTKNK 1830
++ E L +E L K E+ + ++ + K+E + M EL +
Sbjct: 578 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 637
Query: 1831 MILYQKKN 1838
+ + +N
Sbjct: 638 KKIKELQN 645
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 189 bits (479), Expect = 4e-47
Identities = 268/1295 (20%), Positives = 575/1295 (44%), Gaps = 145/1295 (11%)
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETT 1207
+L++ ++E++ + A K+ Q KA A++ K+ +++ +E V EE
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545
Query: 1208 PPVMEQPVTKKVKIQGRGASG-----ISGRRSTAGDGSSWR-DDLCRLMALRISGSQTKM 1261
+Q + + ++Q S R++ A + S R ++ R++ L++ ++ +
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1605
Query: 1262 --SENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFI 1319
+E L A+E + + E + + ++ ES+ +V +
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKAEA 1662
Query: 1320 QEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDM-LGLEETQVILK---KGKKVIF 1375
+ ++ +Q + + ++ +E R + ++AR + + LE Q + + K+ F
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722
Query: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMA 1435
E T E S +EE + ++ + Q++ + + + E +E + E
Sbjct: 1723 AEK---TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779
Query: 1436 TL--EEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
L + + V Q+ L E A + ++ E R+ KA ++ +R L E+
Sbjct: 1780 RLRLQAEEVAQQKSLAQAE----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829
Query: 1494 EKLHQ-------AGEKLSPEEEMLQ-EDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVT 1545
E Q A ++L+ E+E+++ + + E+ +Q+ E L+ +E ++
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889
Query: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-------RKLAQE 1598
LE E+++ E E + + R +E + ++R AE R +E R LA+E
Sbjct: 1890 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1949
Query: 1599 ---EEKLAQEE--RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
+ +LA+E+ RQ A+ ER LA+ I + R +AE +KE E+L +
Sbjct: 1950 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA----ENERLRR 2005
Query: 1654 EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE 1713
AE A +R++L E+ A+ + + ++ LA+++ ++E ++ Q ++
Sbjct: 2006 LAEDEAFQRRRLE---EQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQ 2059
Query: 1714 LAQELEELEWDMEELSWKEEELNQEEGKL---VEEKKKLAEEEEALAWQREKLSEEETKL 1770
+ +E+ L+ E+ + + EL E G++ E+ + E+ E A ++ +L+ EE +
Sbjct: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119
Query: 1771 AQEEELLIQE----KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL 1826
+E E +Q+ +E+ A+ ++ EE ERL K E+ + + Q+ R + +E
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179
Query: 1827 TKNKMILYQKKNL--AQEKKN-----LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKN 1879
+ ++ +K + Q+K+ L QE+ L Q + + +++ VQ +
Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2239
Query: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKK-QEKLAQEKMKLA 1938
+ + + + E +E + + A EK + E A++ Q + A + K A
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299
Query: 1939 LEKAMVQGKK----RLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSR 1994
+ M + KK LR + + +E L L+++ +K L E + L K E E +R
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAAR 2358
Query: 1995 QRKMTQVEQELFERKLSLEEK--------------ILLHEDRILAMEESEIAKGKLEFTR 2040
QR +QVE+ELF ++ +EE IL +D + E K K
Sbjct: 2359 QR--SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416
Query: 2041 GQRIFVQGQ-----RKLAKA--------SRKLIKKRESLSKEPAKLNKILKALQ------ 2081
R+ V Q R+LA+ + K++K++ +E +L + LQ
Sbjct: 2417 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2476
Query: 2082 -----KLTRDERKLTQEEIKMTK-MKRALFVKERR---LSIEQSKLDIKEWDFSEKRSEL 2132
+L D+ ++ Q+ + T+ +R L + +R +S E +L ++ + S ++
Sbjct: 2477 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2536
Query: 2133 TKDEKKLARKQRKLANKMRRM-INKEEKMT---------EEESKLARKHSEVILD-DEEE 2181
+D ++ ++ ++ K+ R + +EK+T ++ A + E I + + E+
Sbjct: 2537 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2596
Query: 2182 GGIEEEEVIPFLK----RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL--- 2234
+++E + LK + ++ + + ++ F S+ D + E F E+ ++ L
Sbjct: 2597 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2656
Query: 2235 --DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
DE+ K + L E++ ++++ E+ + V EE R+ + E EE K+EE ++ +++
Sbjct: 2657 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2716
Query: 2293 EKKKEE-VQEKEEVFEEKEEIMSEEETESLSDEEE 2326
+++EE + E+ + E+ +++ E+ +L+ EE
Sbjct: 2717 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2751
Score = 172 bits (436), Expect = 4e-42
Identities = 265/1216 (21%), Positives = 541/1216 (44%), Gaps = 180/1216 (14%)
Query: 1295 KKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEV-MPREEEQAQKK 1353
++E+K L + + +VV E+ + Q+ ++ IQ Q++ + E + + QA+
Sbjct: 1524 EREAKELQQRMQEEVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAEIQAKARQAEAA 1580
Query: 1354 ARDMLGLEETQVILKKGKKVIFLEPGNV----------TMGKEISKKEEKKTFQKSPKQG 1403
R L +EE +++ + + G E K++ ++ ++ +Q
Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1640
Query: 1404 RKAVQKERKVG-------KIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPS 1456
+ Q++R+ K + E +E++ + +EE+ L+ + ++ + +ER
Sbjct: 1641 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR-LQAEEAERRLRQAEVERARQ 1699
Query: 1457 WQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEE----KLHQAGEKLSPEE---EM 1509
Q + + +++++ A K +R LQEE +L + E+ + ++ E
Sbjct: 1700 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1759
Query: 1510 LQEDKKLKWEEW----------KQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
+E+ + + E W + E + KS Q ++++ E E R G+ +EQ
Sbjct: 1760 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1819
Query: 1560 ---------QVTEEQRHIQEEHKWARIHRK----RARAEKKRAQEERKLAQEEEKLAQEE 1606
Q E+QR + E R+ + R RAE ++ +++R+L +EE LA+ +
Sbjct: 1820 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE--LARLQ 1877
Query: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA 1666
R+ A +K + ++ + EM A+ EE EK Q E A + ++LA
Sbjct: 1878 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1937
Query: 1667 KKWEKV------AREEEKLAKKGG--KLAEVKNILAQKV--------------------- 1697
++ ++ A+ + +LA++ + AE + +LA+K+
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1997
Query: 1698 ---EELPQREQNLDWQEKELAQELEELEWDMEE-----LSWKEEELNQEEGKLVEE--KK 1747
E L + ++ +Q + L ++ + + D+EE + EL +++G LVE+ ++
Sbjct: 1998 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG-LVEDTLRQ 2056
Query: 1748 KLAEEEEALAWQ---------REKLSEEETKLAQEEELLIQEKEKL---AQHKEKMPEEE 1795
+ EEE LA + + +L E ++ E ++ KE+ A + ++ EE
Sbjct: 2057 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2116
Query: 1796 ERLGRKREQLIEKKMKLAQKRERWIN-SMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
ER R+ E+ ++K + ++ R ++EE+ + K + + + L + + + + +LA
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176
Query: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
Q E H+ V+ K + L Q + L Q + + E E+
Sbjct: 2177 QEAAQKRLQAEEKAHA----FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232
Query: 1915 KLVQVEDSLAKKQ------EKLAQEKMKLALEKAMVQ-GKKRLRGELDIAKEEKALNLEM 1967
VQ E A+ + E+L Q + A +A Q ++LR E A++E A +
Sbjct: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE---AEQEAARRAQA 2289
Query: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME 2027
++ A + + + + K +T RQ+ QVEQEL +L LEE H+ +L
Sbjct: 2290 EQAALRQKQAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRLQLEETD--HQKNLL--- 2342
Query: 2028 ESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDE 2087
+ E+ + K E T R Q + +L ++ E LSK A++ +AL +D
Sbjct: 2343 DEELQRLKAEATEAARQRSQVEEELFSVRVQM----EELSKLKARIEAENRALILRDKDN 2398
Query: 2088 -RKLTQEEIKMTKMKRALFVKERRLSI---EQSKL-DIKEWDFSEKRS------------ 2130
++ QEE + KMK+ + + RLS+ E ++L + E D +++R+
Sbjct: 2399 TQRFLQEEAE--KMKQ-VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2455
Query: 2131 --ELT--KDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE 2186
E T K E +L ++Q++LA + R + ++++ ++ + + L+ E + +E
Sbjct: 2456 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Query: 2187 EEVIPFLKRRWRKRKEAK-RGDKPKEKFSSQVDEVESEEHFSE----EMESLLDELEKQE 2241
LK R + A+ R ++ ++F Q +E+ + H +E E +L+ LE Q
Sbjct: 2516 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ- 2574
Query: 2242 SLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
++ + + ER E + E E E KE+ + E K ++ + EE + ++E+ +E Q
Sbjct: 2575 ------RQQSDHDAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627
Query: 2302 KEEVF-EEKEEIMS-----EEETESLSD--EEEEEESCSLEEEVDREKEILKKEKQ---F 2350
++ F EK+ ++ E+E L ++E ++ L EE R+++ +++E+Q
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687
Query: 2351 KLQEQRRKSLRGRERV 2366
++E RR+ E V
Sbjct: 2688 SMEEARRRQHEAEEGV 2703
Score = 154 bits (390), Expect = 9e-37
Identities = 227/999 (22%), Positives = 433/999 (43%), Gaps = 130/999 (13%)
Query: 1504 SPEEEMLQE--DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE--KEQ 1559
S E ++QE D + + E + + S+ + +EEE E++ + E E + +
Sbjct: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL--AQEERQLAQEERKLA 1617
E+QR + E H A+ +R E ++ +E + +EE + Q++R + +E ++L
Sbjct: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1563
Query: 1618 QAYVKITQDDREMAQAEGKF------------AQKEETLAQRG------EKLSQEAEKLA 1659
Q+ Q A+A + Q E T QRG + L AE+
Sbjct: 1564 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1623
Query: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
++++ ++ E++ R+ + +++ + AEV+ K E RE ++ Q LE
Sbjct: 1624 AQKRQAQEEAERLRRQVQDESQR-KRQAEVELASRVKAEAEAARE------KQRALQALE 1676
Query: 1720 ELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQ 1779
EL EE + + E + V+ + A+ Q ++ S E K AQ E L +
Sbjct: 1677 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQE 1735
Query: 1780 EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW---INSMEELTKNKMILYQK 1836
E +AQ + EE ER +++ + + + ++ ERW N L + Q+
Sbjct: 1736 EHVAVAQ----LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 1837 KNLAQ-EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL--GMFNKILAQVEE 1893
K+LAQ E + +E E+ A+R+ R +Q ++ + +L G + LA +E
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Query: 1894 --KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE-KAMVQGKKRL 1950
+L E E ++++ L E +L + + +K+++L E K+ E + ++ K R
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1911
Query: 1951 RGELDIAKEEKALNLE-----MKRLAEEKMRL-VEGKETLSKGETPETSRQRKMTQVEQE 2004
E E+ LE + LAEE RL +E + + E R+ + E+
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971
Query: 2005 LFERKLSLEEKILLHEDRILAMEESEIAKGKL------EFTRGQRIFVQGQRKLAKASRK 2058
L E+ ++ E L + +A++E E +L E + +R+ Q + A +
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031
Query: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEI---KMTKMKRALFVKERRLSIEQ 2115
L + R++ E + K L + T +R+ +EEI K + K A E L + +
Sbjct: 2032 LAQLRKASDSELER----QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087
Query: 2116 SKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM-----TEEESKLARK 2170
+ + ++ S++++EL + AR+++ A + RR EE++ EEE+ RK
Sbjct: 2088 IRSNAEDTLRSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2142
Query: 2171 HSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK----------------RGDKPKEKFS 2214
L++ E + EE RR R+R E + + ++ F+
Sbjct: 2143 ---AALEEVERLKAKVEEA-----RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194
Query: 2215 SQVDEVESEEHFSEEMESLLDELEKQESL---SSEEEEEREEEEEREEEEVREEEEERKE 2271
Q E E ++ +E +S+LD+L + ++EE EE + ERE + R + EE +
Sbjct: 2195 VQQKEQELQQTLQQE-QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2253
Query: 2272 EEEGEEKQVE-------------KEEEEKKKKKKEKKKEEVQEK--------------EE 2304
++ E+Q + KE E++ ++ + ++ +++K E+
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK-EILKKEKQFKLQEQRRKSLRGR 2363
+K ++ E T L EE + + L+EE+ R K E + +Q E+ S+R +
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
LS L+ + RA+ L + + L A +MK+
Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2412
Score = 122 bits (305), Expect = 7e-27
Identities = 196/962 (20%), Positives = 399/962 (41%), Gaps = 153/962 (15%)
Query: 1536 QQYKDEEEVTLEEEVSREGEEKEQ------QVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589
QQ E +V +E R + E+ Q QR +++ + R +R+ A
Sbjct: 1301 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1360
Query: 1590 QEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE 1649
Q+ R+ ++ + + + Q +E+ + QA + E + + GE
Sbjct: 1361 QDARRRQEQIQAMPLADSQAVREQLRQEQALL--------------------EEIERHGE 1400
Query: 1650 KLSQEAEKLAQKRKKLAKKWE------KVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
K+ +E ++ A++ K +E K E K K+ + Q+ +L
Sbjct: 1401 KV-EECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459
Query: 1704 EQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQRE-- 1761
L + + + E MEE EE L +++ EE+++LAE E AL QR+
Sbjct: 1460 YSELTTLTSQYIKFISETLRRMEE----EERLAEQQR--AEERERLAEVEAALEKQRQLA 1513
Query: 1762 -------KLSEEETKLAQ---EEELLIQEKEKL--AQHKEKMPEEEERLGRKREQLIEKK 1809
+E E K Q +EE++ +E+ + Q K + EE ++L + E I+ K
Sbjct: 1514 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1573
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
+ A+ ER +EE + +++ Q + +++ E + L R E K +
Sbjct: 1574 ARQAEAAERSRLRIEE--EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1631
Query: 1870 SKKQL-VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS--LAKK 1926
++L QV+++ + ++ ++ E E +K+ L E+ +Q E++ ++
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1691
Query: 1927 QEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSK 1986
E ++++ALE A + L+ + + EK LE + L EE + + + +E +
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSK-RASFAEKTAQLE-RSLQEEHVAVAQLREEAER 1749
Query: 1987 GETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046
+ +R + E+EL +L E + L ++ +A+ + E + +
Sbjct: 1750 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--E 1807
Query: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKI--------LKALQKLTR---------DERK 2089
+ R+ KA + +++RE +E K ++ L A Q+L R +R+
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867
Query: 2090 LTQEEI-KMTKMKRALFVKERRLSIEQSK--------LDIKEWDFSEKRSELTKDEKKL- 2139
L +EE+ ++ + A K + L E +K L K E RS K +++L
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1927
Query: 2140 --ARKQRKLANKMRRM------INKEEKMTEEESKLARKHSEVILDD------------- 2178
A + R+LA + R+ ++ ++ EE++ R +E +L +
Sbjct: 1928 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1987
Query: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELE 2238
E E ++E+E R R+ E + + + + + + + EE ++ ++ ELE
Sbjct: 1988 EAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 2044
Query: 2239 KQESLSSEEEEEREEEEE--------------------------REEEEVREEEEERKEE 2272
+Q+ L + +R + EE R E +E+ E
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 2104
Query: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE--------EETESLSDE 2324
E ++Q+ EEE ++++ +E+ ++ + +EE +++ + E EE L +
Sbjct: 2105 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2164
Query: 2325 EEEEESCSL---EEEVDREKEILKKEKQFKLQEQR---RKSLRGRERVLSILRGVPHGKG 2378
E+E + L +E + + +K F +Q++ +++L+ + VL LRG
Sbjct: 2165 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2224
Query: 2379 RA 2380
RA
Sbjct: 2225 RA 2226
Score = 54.7 bits (130), Expect = 1e-06
Identities = 115/578 (19%), Positives = 227/578 (39%), Gaps = 88/578 (15%)
Query: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
+L +KE + +++AE +K +VE L K +L+ E K+ LR E
Sbjct: 1145 RLPLDKEPARECAQRIAEQQKAQAEVE-GLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1203
Query: 1954 LDIA-------KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
L++ + A+ LE + +R +G E + + + + + EL
Sbjct: 1204 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1263
Query: 2007 ERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRG-QRIFVQGQRKLAKASRKLIKKRES 2065
K SL++ R A + + RG Q + + Q++ + ++ + RE
Sbjct: 1264 ATKASLKKL------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1317
Query: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD-IKEWD 2124
++ Q L R + L Q +++ ++++ R+L + D + W
Sbjct: 1318 VA-------------QLLERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWL 1360
Query: 2125 FSEKRSE-----LTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE 2179
+R + + + + R+Q + + I + + EE + A+++ I D E
Sbjct: 1361 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1420
Query: 2180 EEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQV---DEVESEEHFSEEMESLLDE 2236
+ + ++ P A KPK + S+ + V+ H+SE L
Sbjct: 1421 LQLVTYKAQLEPV----------ASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTT 1465
Query: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
L Q E R EEEER E++ EE++ E E +K+++ +
Sbjct: 1466 LTSQYIKFISETLRRMEEEER-----------LAEQQRAEERERLAEVEAALEKQRQLAE 1514
Query: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEE----EEEESCSLEEEVDR-----EKEILKKE 2347
Q K + E +E+ + E + EE +++ S++EE+ + E EI K
Sbjct: 1515 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1574
Query: 2348 KQFKLQEQRRKSLRGRERVLSI-------LRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
+Q + E+ R + RV+ + RG G+ +A+R ++ +K A E
Sbjct: 1575 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK--RQAQEE 1632
Query: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKERE 2438
E+ V ++ + K+ VE+ + + RE
Sbjct: 1633 AERLRRQVQDES---QRKRQAEVELASRVKAEAEAARE 1667
Score = 38.5 bits (88), Expect = 0.097
Identities = 117/632 (18%), Positives = 251/632 (39%), Gaps = 128/632 (20%)
Query: 979 AEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENL 1038
AE+ H + + L QK + +E+ + E DH + +LQ L + + +
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361
Query: 1039 TLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLR 1098
+ E+ FS+ V M E S LK +E + ++ K ++Q++L
Sbjct: 2362 QV----EEELFSVRVQM--EELSKLKARIEAENRALILRD-----------KDNTQRFL- 2403
Query: 1099 GLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEK 1158
+ + KQ++ E L + A ++ E + Q + + ++K
Sbjct: 2404 ---QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------- 2450
Query: 1159 DISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKK 1218
+++Q +++ KA A+ L+++ + ++A+ + E+ ++ + ++
Sbjct: 2451 -----------EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQ 2493
Query: 1219 VKIQGRG-ASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEML 1277
+ + +G + R + S+ + L +L +S +Q + E+ AQ
Sbjct: 2494 LAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMSRAQARAEED--------AQRF- 2543
Query: 1278 VDRHPSWELFQEI--CPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQE 1335
R + E+ +++ L +E L++ L+ I Q+ + ++ E
Sbjct: 2544 --RKQAEEIGEKLHRTELATQEKVTLVQTLE----------IQRQQSDHDAERLREAIAE 2591
Query: 1336 VIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKT 1395
+ R KE + +E + Q K+ +M +++ Q++ + T + S EK +
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-------------TQALQQSFLSEKDS 2638
Query: 1396 FQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455
+Q+ER I++E K E+ +EV + L E+ +Q+
Sbjct: 2639 L----------LQRER---FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---------- 2675
Query: 1456 SWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKK 1515
Q + R+ A EE +R + EE + + E+L E+ ++ ++
Sbjct: 2676 -------------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2722
Query: 1516 LKWEEWKQVWENM-LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTE-EQRHIQEEHK 1573
L EE +++ E + L + EEVT + + + + + + EH
Sbjct: 2723 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2782
Query: 1574 WARIHRKRARAEKKRAQEERKLAQEE-EKLAQ 1604
+ + RK +R QE L+ EE ++LAQ
Sbjct: 2783 FDGLRRK---VSAQRLQEAGILSAEELQRLAQ 2811
Score = 35.0 bits (79), Expect = 1.1
Identities = 95/488 (19%), Positives = 188/488 (38%), Gaps = 76/488 (15%)
Query: 1407 VQKERKVGKIKREMTKEERDMS-------EEVEEMATLEEKVVKQEGKLV-MIERTPSWQ 1458
V ++ + + + + ERD+ E+V+ E+ ++ L + R P Q
Sbjct: 347 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 406
Query: 1459 DWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG--EKLSPEEEMLQEDKKL 1516
D +A E + W+ ++E LL + + H A E+ P E+ ++
Sbjct: 407 DGVRA--------NELQLRWQEYREL--VLLLLQWMRHHTAAFEERRFPSSF---EEIEI 453
Query: 1517 KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWAR 1576
W ++ + E L +K ++ +LE V + + +V + E +W +
Sbjct: 454 LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAV----QAGQLKVPPGYHPLDVEKEWGK 509
Query: 1577 IHRKRARAEKK-RAQEER---------KLAQE----EEKLAQEERQLAQEERKLAQAYV- 1621
+H EK+ R++ ER KL E EE+L Q + L + R LA V
Sbjct: 510 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 569
Query: 1622 -KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
+ + +R++ +A+ + + + E++ ++ +L ++ + R E L
Sbjct: 570 QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI-RTEYNLR 628
Query: 1681 KKGGKLA---EVKNILAQKVEELPQREQN--------LDWQEKELAQELEELEWDMEELS 1729
K G A +V + Q V+ P+ E + L W E E ++ EW + +L
Sbjct: 629 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE-ENQHRVDGAEWGV-DLP 686
Query: 1730 WKEEELNQEEG--KLVEEKKKLAEEEEALAWQRE------------KLSEEETKLAQEEE 1775
E +L G + +EE + E + Q +L + KL +
Sbjct: 687 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 746
Query: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLI-----EKKMKLAQKRERWINSMEELTKNK 1830
++ E L +E L K E+ + ++ + K+E + M EL +
Sbjct: 747 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 806
Query: 1831 MILYQKKN 1838
+ + +N
Sbjct: 807 KKIKELQN 814
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 189 bits (479), Expect = 4e-47
Identities = 268/1295 (20%), Positives = 575/1295 (44%), Gaps = 145/1295 (11%)
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETT 1207
+L++ ++E++ + A K+ Q KA A++ K+ +++ +E V EE
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386
Query: 1208 PPVMEQPVTKKVKIQGRGASG-----ISGRRSTAGDGSSWR-DDLCRLMALRISGSQTKM 1261
+Q + + ++Q S R++ A + S R ++ R++ L++ ++ +
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446
Query: 1262 --SENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFI 1319
+E L A+E + + E + + ++ ES+ +V +
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKAEA 1503
Query: 1320 QEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDM-LGLEETQVILK---KGKKVIF 1375
+ ++ +Q + + ++ +E R + ++AR + + LE Q + + K+ F
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1563
Query: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMA 1435
E T E S +EE + ++ + Q++ + + + E +E + E
Sbjct: 1564 AEK---TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
Query: 1436 TL--EEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
L + + V Q+ L E A + ++ E R+ KA ++ +R L E+
Sbjct: 1621 RLRLQAEEVAQQKSLAQAE----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670
Query: 1494 EKLHQ-------AGEKLSPEEEMLQ-EDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVT 1545
E Q A ++L+ E+E+++ + + E+ +Q+ E L+ +E ++
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730
Query: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-------RKLAQE 1598
LE E+++ E E + + R +E + ++R AE R +E R LA+E
Sbjct: 1731 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1790
Query: 1599 ---EEKLAQEE--RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
+ +LA+E+ RQ A+ ER LA+ I + R +AE +KE E+L +
Sbjct: 1791 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA----ENERLRR 1846
Query: 1654 EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE 1713
AE A +R++L E+ A+ + + ++ LA+++ ++E ++ Q ++
Sbjct: 1847 LAEDEAFQRRRLE---EQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQ 1900
Query: 1714 LAQELEELEWDMEELSWKEEELNQEEGKL---VEEKKKLAEEEEALAWQREKLSEEETKL 1770
+ +E+ L+ E+ + + EL E G++ E+ + E+ E A ++ +L+ EE +
Sbjct: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960
Query: 1771 AQEEELLIQE----KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL 1826
+E E +Q+ +E+ A+ ++ EE ERL K E+ + + Q+ R + +E
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
Query: 1827 TKNKMILYQKKNL--AQEKKN-----LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKN 1879
+ ++ +K + Q+K+ L QE+ L Q + + +++ VQ +
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2080
Query: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKK-QEKLAQEKMKLA 1938
+ + + + E +E + + A EK + E A++ Q + A + K A
Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140
Query: 1939 LEKAMVQGKK----RLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSR 1994
+ M + KK LR + + +E L L+++ +K L E + L K E E +R
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAAR 2199
Query: 1995 QRKMTQVEQELFERKLSLEEK--------------ILLHEDRILAMEESEIAKGKLEFTR 2040
QR +QVE+ELF ++ +EE IL +D + E K K
Sbjct: 2200 QR--SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257
Query: 2041 GQRIFVQGQ-----RKLAKA--------SRKLIKKRESLSKEPAKLNKILKALQ------ 2081
R+ V Q R+LA+ + K++K++ +E +L + LQ
Sbjct: 2258 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2317
Query: 2082 -----KLTRDERKLTQEEIKMTK-MKRALFVKERR---LSIEQSKLDIKEWDFSEKRSEL 2132
+L D+ ++ Q+ + T+ +R L + +R +S E +L ++ + S ++
Sbjct: 2318 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2377
Query: 2133 TKDEKKLARKQRKLANKMRRM-INKEEKMT---------EEESKLARKHSEVILD-DEEE 2181
+D ++ ++ ++ K+ R + +EK+T ++ A + E I + + E+
Sbjct: 2378 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2437
Query: 2182 GGIEEEEVIPFLK----RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL--- 2234
+++E + LK + ++ + + ++ F S+ D + E F E+ ++ L
Sbjct: 2438 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2497
Query: 2235 --DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
DE+ K + L E++ ++++ E+ + V EE R+ + E EE K+EE ++ +++
Sbjct: 2498 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2557
Query: 2293 EKKKEE-VQEKEEVFEEKEEIMSEEETESLSDEEE 2326
+++EE + E+ + E+ +++ E+ +L+ EE
Sbjct: 2558 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2592
Score = 172 bits (436), Expect = 4e-42
Identities = 265/1216 (21%), Positives = 541/1216 (44%), Gaps = 180/1216 (14%)
Query: 1295 KKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEV-MPREEEQAQKK 1353
++E+K L + + +VV E+ + Q+ ++ IQ Q++ + E + + QA+
Sbjct: 1365 EREAKELQQRMQEEVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAEIQAKARQAEAA 1421
Query: 1354 ARDMLGLEETQVILKKGKKVIFLEPGNV----------TMGKEISKKEEKKTFQKSPKQG 1403
R L +EE +++ + + G E K++ ++ ++ +Q
Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1481
Query: 1404 RKAVQKERKVG-------KIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPS 1456
+ Q++R+ K + E +E++ + +EE+ L+ + ++ + +ER
Sbjct: 1482 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR-LQAEEAERRLRQAEVERARQ 1540
Query: 1457 WQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEE----KLHQAGEKLSPEE---EM 1509
Q + + +++++ A K +R LQEE +L + E+ + ++ E
Sbjct: 1541 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1600
Query: 1510 LQEDKKLKWEEW----------KQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
+E+ + + E W + E + KS Q ++++ E E R G+ +EQ
Sbjct: 1601 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1660
Query: 1560 ---------QVTEEQRHIQEEHKWARIHRK----RARAEKKRAQEERKLAQEEEKLAQEE 1606
Q E+QR + E R+ + R RAE ++ +++R+L +EE LA+ +
Sbjct: 1661 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE--LARLQ 1718
Query: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA 1666
R+ A +K + ++ + EM A+ EE EK Q E A + ++LA
Sbjct: 1719 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1778
Query: 1667 KKWEKV------AREEEKLAKKGG--KLAEVKNILAQKV--------------------- 1697
++ ++ A+ + +LA++ + AE + +LA+K+
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1838
Query: 1698 ---EELPQREQNLDWQEKELAQELEELEWDMEE-----LSWKEEELNQEEGKLVEE--KK 1747
E L + ++ +Q + L ++ + + D+EE + EL +++G LVE+ ++
Sbjct: 1839 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG-LVEDTLRQ 1897
Query: 1748 KLAEEEEALAWQ---------REKLSEEETKLAQEEELLIQEKEKL---AQHKEKMPEEE 1795
+ EEE LA + + +L E ++ E ++ KE+ A + ++ EE
Sbjct: 1898 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1957
Query: 1796 ERLGRKREQLIEKKMKLAQKRERWIN-SMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
ER R+ E+ ++K + ++ R ++EE+ + K + + + L + + + + +LA
Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2017
Query: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
Q E H+ V+ K + L Q + L Q + + E E+
Sbjct: 2018 QEAAQKRLQAEEKAHA----FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
Query: 1915 KLVQVEDSLAKKQ------EKLAQEKMKLALEKAMVQ-GKKRLRGELDIAKEEKALNLEM 1967
VQ E A+ + E+L Q + A +A Q ++LR E A++E A +
Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE---AEQEAARRAQA 2130
Query: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME 2027
++ A + + + + K +T RQ+ QVEQEL +L LEE H+ +L
Sbjct: 2131 EQAALRQKQAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRLQLEETD--HQKNLL--- 2183
Query: 2028 ESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDE 2087
+ E+ + K E T R Q + +L ++ E LSK A++ +AL +D
Sbjct: 2184 DEELQRLKAEATEAARQRSQVEEELFSVRVQM----EELSKLKARIEAENRALILRDKDN 2239
Query: 2088 -RKLTQEEIKMTKMKRALFVKERRLSI---EQSKL-DIKEWDFSEKRS------------ 2130
++ QEE + KMK+ + + RLS+ E ++L + E D +++R+
Sbjct: 2240 TQRFLQEEAE--KMKQ-VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2296
Query: 2131 --ELT--KDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE 2186
E T K E +L ++Q++LA + R + ++++ ++ + + L+ E + +E
Sbjct: 2297 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356
Query: 2187 EEVIPFLKRRWRKRKEAK-RGDKPKEKFSSQVDEVESEEHFSE----EMESLLDELEKQE 2241
LK R + A+ R ++ ++F Q +E+ + H +E E +L+ LE Q
Sbjct: 2357 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ- 2415
Query: 2242 SLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
++ + + ER E + E E E KE+ + E K ++ + EE + ++E+ +E Q
Sbjct: 2416 ------RQQSDHDAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468
Query: 2302 KEEVF-EEKEEIMS-----EEETESLSD--EEEEEESCSLEEEVDREKEILKKEKQ---F 2350
++ F EK+ ++ E+E L ++E ++ L EE R+++ +++E+Q
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528
Query: 2351 KLQEQRRKSLRGRERV 2366
++E RR+ E V
Sbjct: 2529 SMEEARRRQHEAEEGV 2544
Score = 154 bits (390), Expect = 9e-37
Identities = 227/999 (22%), Positives = 433/999 (43%), Gaps = 130/999 (13%)
Query: 1504 SPEEEMLQE--DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE--KEQ 1559
S E ++QE D + + E + + S+ + +EEE E++ + E E + +
Sbjct: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL--AQEERQLAQEERKLA 1617
E+QR + E H A+ +R E ++ +E + +EE + Q++R + +E ++L
Sbjct: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1404
Query: 1618 QAYVKITQDDREMAQAEGKF------------AQKEETLAQRG------EKLSQEAEKLA 1659
Q+ Q A+A + Q E T QRG + L AE+
Sbjct: 1405 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1464
Query: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
++++ ++ E++ R+ + +++ + AEV+ K E RE ++ Q LE
Sbjct: 1465 AQKRQAQEEAERLRRQVQDESQR-KRQAEVELASRVKAEAEAARE------KQRALQALE 1517
Query: 1720 ELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQ 1779
EL EE + + E + V+ + A+ Q ++ S E K AQ E L +
Sbjct: 1518 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQE 1576
Query: 1780 EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW---INSMEELTKNKMILYQK 1836
E +AQ + EE ER +++ + + + ++ ERW N L + Q+
Sbjct: 1577 EHVAVAQ----LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 1837 KNLAQ-EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL--GMFNKILAQVEE 1893
K+LAQ E + +E E+ A+R+ R +Q ++ + +L G + LA +E
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Query: 1894 --KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE-KAMVQGKKRL 1950
+L E E ++++ L E +L + + +K+++L E K+ E + ++ K R
Sbjct: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1752
Query: 1951 RGELDIAKEEKALNLE-----MKRLAEEKMRL-VEGKETLSKGETPETSRQRKMTQVEQE 2004
E E+ LE + LAEE RL +E + + E R+ + E+
Sbjct: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812
Query: 2005 LFERKLSLEEKILLHEDRILAMEESEIAKGKL------EFTRGQRIFVQGQRKLAKASRK 2058
L E+ ++ E L + +A++E E +L E + +R+ Q + A +
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872
Query: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEI---KMTKMKRALFVKERRLSIEQ 2115
L + R++ E + K L + T +R+ +EEI K + K A E L + +
Sbjct: 1873 LAQLRKASDSELER----QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928
Query: 2116 SKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM-----TEEESKLARK 2170
+ + ++ S++++EL + AR+++ A + RR EE++ EEE+ RK
Sbjct: 1929 IRSNAEDTLRSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1983
Query: 2171 HSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK----------------RGDKPKEKFS 2214
L++ E + EE RR R+R E + + ++ F+
Sbjct: 1984 ---AALEEVERLKAKVEEA-----RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035
Query: 2215 SQVDEVESEEHFSEEMESLLDELEKQESL---SSEEEEEREEEEEREEEEVREEEEERKE 2271
Q E E ++ +E +S+LD+L + ++EE EE + ERE + R + EE +
Sbjct: 2036 VQQKEQELQQTLQQE-QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2094
Query: 2272 EEEGEEKQVE-------------KEEEEKKKKKKEKKKEEVQEK--------------EE 2304
++ E+Q + KE E++ ++ + ++ +++K E+
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK-EILKKEKQFKLQEQRRKSLRGR 2363
+K ++ E T L EE + + L+EE+ R K E + +Q E+ S+R +
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
LS L+ + RA+ L + + L A +MK+
Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2253
Score = 122 bits (305), Expect = 7e-27
Identities = 196/962 (20%), Positives = 399/962 (41%), Gaps = 153/962 (15%)
Query: 1536 QQYKDEEEVTLEEEVSREGEEKEQ------QVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589
QQ E +V +E R + E+ Q QR +++ + R +R+ A
Sbjct: 1142 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1201
Query: 1590 QEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE 1649
Q+ R+ ++ + + + Q +E+ + QA + E + + GE
Sbjct: 1202 QDARRRQEQIQAMPLADSQAVREQLRQEQALL--------------------EEIERHGE 1241
Query: 1650 KLSQEAEKLAQKRKKLAKKWE------KVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
K+ +E ++ A++ K +E K E K K+ + Q+ +L
Sbjct: 1242 KV-EECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300
Query: 1704 EQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQRE-- 1761
L + + + E MEE EE L +++ EE+++LAE E AL QR+
Sbjct: 1301 YSELTTLTSQYIKFISETLRRMEE----EERLAEQQR--AEERERLAEVEAALEKQRQLA 1354
Query: 1762 -------KLSEEETKLAQ---EEELLIQEKEKL--AQHKEKMPEEEERLGRKREQLIEKK 1809
+E E K Q +EE++ +E+ + Q K + EE ++L + E I+ K
Sbjct: 1355 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1414
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
+ A+ ER +EE + +++ Q + +++ E + L R E K +
Sbjct: 1415 ARQAEAAERSRLRIEE--EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1472
Query: 1870 SKKQL-VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS--LAKK 1926
++L QV+++ + ++ ++ E E +K+ L E+ +Q E++ ++
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1532
Query: 1927 QEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSK 1986
E ++++ALE A + L+ + + EK LE + L EE + + + +E +
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSK-RASFAEKTAQLE-RSLQEEHVAVAQLREEAER 1590
Query: 1987 GETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046
+ +R + E+EL +L E + L ++ +A+ + E + +
Sbjct: 1591 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--E 1648
Query: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKI--------LKALQKLTR---------DERK 2089
+ R+ KA + +++RE +E K ++ L A Q+L R +R+
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708
Query: 2090 LTQEEI-KMTKMKRALFVKERRLSIEQSK--------LDIKEWDFSEKRSELTKDEKKL- 2139
L +EE+ ++ + A K + L E +K L K E RS K +++L
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1768
Query: 2140 --ARKQRKLANKMRRM------INKEEKMTEEESKLARKHSEVILDD------------- 2178
A + R+LA + R+ ++ ++ EE++ R +E +L +
Sbjct: 1769 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1828
Query: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELE 2238
E E ++E+E R R+ E + + + + + + + EE ++ ++ ELE
Sbjct: 1829 EAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1885
Query: 2239 KQESLSSEEEEEREEEEE--------------------------REEEEVREEEEERKEE 2272
+Q+ L + +R + EE R E +E+ E
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1945
Query: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE--------EETESLSDE 2324
E ++Q+ EEE ++++ +E+ ++ + +EE +++ + E EE L +
Sbjct: 1946 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2005
Query: 2325 EEEEESCSL---EEEVDREKEILKKEKQFKLQEQR---RKSLRGRERVLSILRGVPHGKG 2378
E+E + L +E + + +K F +Q++ +++L+ + VL LRG
Sbjct: 2006 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2065
Query: 2379 RA 2380
RA
Sbjct: 2066 RA 2067
Score = 54.7 bits (130), Expect = 1e-06
Identities = 115/578 (19%), Positives = 227/578 (39%), Gaps = 88/578 (15%)
Query: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
+L +KE + +++AE +K +VE L K +L+ E K+ LR E
Sbjct: 986 RLPLDKEPARECAQRIAEQQKAQAEVE-GLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1044
Query: 1954 LDIA-------KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
L++ + A+ LE + +R +G E + + + + + EL
Sbjct: 1045 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1104
Query: 2007 ERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRG-QRIFVQGQRKLAKASRKLIKKRES 2065
K SL++ R A + + RG Q + + Q++ + ++ + RE
Sbjct: 1105 ATKASLKKL------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1158
Query: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD-IKEWD 2124
++ Q L R + L Q +++ ++++ R+L + D + W
Sbjct: 1159 VA-------------QLLERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWL 1201
Query: 2125 FSEKRSE-----LTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE 2179
+R + + + + R+Q + + I + + EE + A+++ I D E
Sbjct: 1202 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1261
Query: 2180 EEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQV---DEVESEEHFSEEMESLLDE 2236
+ + ++ P A KPK + S+ + V+ H+SE L
Sbjct: 1262 LQLVTYKAQLEPV----------ASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTT 1306
Query: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
L Q E R EEEER E++ EE++ E E +K+++ +
Sbjct: 1307 LTSQYIKFISETLRRMEEEER-----------LAEQQRAEERERLAEVEAALEKQRQLAE 1355
Query: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEE----EEEESCSLEEEVDR-----EKEILKKE 2347
Q K + E +E+ + E + EE +++ S++EE+ + E EI K
Sbjct: 1356 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1415
Query: 2348 KQFKLQEQRRKSLRGRERVLSI-------LRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
+Q + E+ R + RV+ + RG G+ +A+R ++ +K A E
Sbjct: 1416 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK--RQAQEE 1473
Query: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKERE 2438
E+ V ++ + K+ VE+ + + RE
Sbjct: 1474 AERLRRQVQDES---QRKRQAEVELASRVKAEAEAARE 1508
Score = 38.5 bits (88), Expect = 0.097
Identities = 117/632 (18%), Positives = 251/632 (39%), Gaps = 128/632 (20%)
Query: 979 AEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENL 1038
AE+ H + + L QK + +E+ + E DH + +LQ L + + +
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202
Query: 1039 TLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLR 1098
+ E+ FS+ V M E S LK +E + ++ K ++Q++L
Sbjct: 2203 QV----EEELFSVRVQM--EELSKLKARIEAENRALILRD-----------KDNTQRFL- 2244
Query: 1099 GLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEK 1158
+ + KQ++ E L + A ++ E + Q + + ++K
Sbjct: 2245 ---QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------- 2291
Query: 1159 DISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKK 1218
+++Q +++ KA A+ L+++ + ++A+ + E+ ++ + ++
Sbjct: 2292 -----------EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQ 2334
Query: 1219 VKIQGRG-ASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEML 1277
+ + +G + R + S+ + L +L +S +Q + E+ AQ
Sbjct: 2335 LAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMSRAQARAEED--------AQRF- 2384
Query: 1278 VDRHPSWELFQEI--CPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQE 1335
R + E+ +++ L +E L++ L+ I Q+ + ++ E
Sbjct: 2385 --RKQAEEIGEKLHRTELATQEKVTLVQTLE----------IQRQQSDHDAERLREAIAE 2432
Query: 1336 VIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKT 1395
+ R KE + +E + Q K+ +M +++ Q++ + T + S EK +
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-------------TQALQQSFLSEKDS 2479
Query: 1396 FQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455
+Q+ER I++E K E+ +EV + L E+ +Q+
Sbjct: 2480 L----------LQRER---FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---------- 2516
Query: 1456 SWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKK 1515
Q + R+ A EE +R + EE + + E+L E+ ++ ++
Sbjct: 2517 -------------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2563
Query: 1516 LKWEEWKQVWENM-LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTE-EQRHIQEEHK 1573
L EE +++ E + L + EEVT + + + + + + EH
Sbjct: 2564 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2623
Query: 1574 WARIHRKRARAEKKRAQEERKLAQEE-EKLAQ 1604
+ + RK +R QE L+ EE ++LAQ
Sbjct: 2624 FDGLRRK---VSAQRLQEAGILSAEELQRLAQ 2652
Score = 35.0 bits (79), Expect = 1.1
Identities = 95/488 (19%), Positives = 188/488 (38%), Gaps = 76/488 (15%)
Query: 1407 VQKERKVGKIKREMTKEERDMS-------EEVEEMATLEEKVVKQEGKLV-MIERTPSWQ 1458
V ++ + + + + ERD+ E+V+ E+ ++ L + R P Q
Sbjct: 188 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 247
Query: 1459 DWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG--EKLSPEEEMLQEDKKL 1516
D +A E + W+ ++E LL + + H A E+ P E+ ++
Sbjct: 248 DGVRA--------NELQLRWQEYREL--VLLLLQWMRHHTAAFEERRFPSSF---EEIEI 294
Query: 1517 KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWAR 1576
W ++ + E L +K ++ +LE V + + +V + E +W +
Sbjct: 295 LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAV----QAGQLKVPPGYHPLDVEKEWGK 350
Query: 1577 IHRKRARAEKK-RAQEER---------KLAQE----EEKLAQEERQLAQEERKLAQAYV- 1621
+H EK+ R++ ER KL E EE+L Q + L + R LA V
Sbjct: 351 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 410
Query: 1622 -KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
+ + +R++ +A+ + + + E++ ++ +L ++ + R E L
Sbjct: 411 QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI-RTEYNLR 469
Query: 1681 KKGGKLA---EVKNILAQKVEELPQREQN--------LDWQEKELAQELEELEWDMEELS 1729
K G A +V + Q V+ P+ E + L W E E ++ EW + +L
Sbjct: 470 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE-ENQHRVDGAEWGV-DLP 527
Query: 1730 WKEEELNQEEG--KLVEEKKKLAEEEEALAWQRE------------KLSEEETKLAQEEE 1775
E +L G + +EE + E + Q +L + KL +
Sbjct: 528 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 587
Query: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLI-----EKKMKLAQKRERWINSMEELTKNK 1830
++ E L +E L K E+ + ++ + K+E + M EL +
Sbjct: 588 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 647
Query: 1831 MILYQKKN 1838
+ + +N
Sbjct: 648 KKIKELQN 655
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 189 bits (479), Expect = 4e-47
Identities = 268/1295 (20%), Positives = 575/1295 (44%), Gaps = 145/1295 (11%)
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETT 1207
+L++ ++E++ + A K+ Q KA A++ K+ +++ +E V EE
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394
Query: 1208 PPVMEQPVTKKVKIQGRGASG-----ISGRRSTAGDGSSWR-DDLCRLMALRISGSQTKM 1261
+Q + + ++Q S R++ A + S R ++ R++ L++ ++ +
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1454
Query: 1262 --SENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFI 1319
+E L A+E + + E + + ++ ES+ +V +
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKAEA 1511
Query: 1320 QEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDM-LGLEETQVILK---KGKKVIF 1375
+ ++ +Q + + ++ +E R + ++AR + + LE Q + + K+ F
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1571
Query: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMA 1435
E T E S +EE + ++ + Q++ + + + E +E + E
Sbjct: 1572 AEK---TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1628
Query: 1436 TL--EEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
L + + V Q+ L E A + ++ E R+ KA ++ +R L E+
Sbjct: 1629 RLRLQAEEVAQQKSLAQAE----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678
Query: 1494 EKLHQ-------AGEKLSPEEEMLQ-EDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVT 1545
E Q A ++L+ E+E+++ + + E+ +Q+ E L+ +E ++
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738
Query: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-------RKLAQE 1598
LE E+++ E E + + R +E + ++R AE R +E R LA+E
Sbjct: 1739 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1798
Query: 1599 ---EEKLAQEE--RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
+ +LA+E+ RQ A+ ER LA+ I + R +AE +KE E+L +
Sbjct: 1799 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA----ENERLRR 1854
Query: 1654 EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE 1713
AE A +R++L E+ A+ + + ++ LA+++ ++E ++ Q ++
Sbjct: 1855 LAEDEAFQRRRLE---EQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQ 1908
Query: 1714 LAQELEELEWDMEELSWKEEELNQEEGKL---VEEKKKLAEEEEALAWQREKLSEEETKL 1770
+ +E+ L+ E+ + + EL E G++ E+ + E+ E A ++ +L+ EE +
Sbjct: 1909 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1968
Query: 1771 AQEEELLIQE----KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL 1826
+E E +Q+ +E+ A+ ++ EE ERL K E+ + + Q+ R + +E
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028
Query: 1827 TKNKMILYQKKNL--AQEKKN-----LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKN 1879
+ ++ +K + Q+K+ L QE+ L Q + + +++ VQ +
Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2088
Query: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKK-QEKLAQEKMKLA 1938
+ + + + E +E + + A EK + E A++ Q + A + K A
Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2148
Query: 1939 LEKAMVQGKK----RLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSR 1994
+ M + KK LR + + +E L L+++ +K L E + L K E E +R
Sbjct: 2149 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAAR 2207
Query: 1995 QRKMTQVEQELFERKLSLEEK--------------ILLHEDRILAMEESEIAKGKLEFTR 2040
QR +QVE+ELF ++ +EE IL +D + E K K
Sbjct: 2208 QR--SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265
Query: 2041 GQRIFVQGQ-----RKLAKA--------SRKLIKKRESLSKEPAKLNKILKALQ------ 2081
R+ V Q R+LA+ + K++K++ +E +L + LQ
Sbjct: 2266 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2325
Query: 2082 -----KLTRDERKLTQEEIKMTK-MKRALFVKERR---LSIEQSKLDIKEWDFSEKRSEL 2132
+L D+ ++ Q+ + T+ +R L + +R +S E +L ++ + S ++
Sbjct: 2326 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2385
Query: 2133 TKDEKKLARKQRKLANKMRRM-INKEEKMT---------EEESKLARKHSEVILD-DEEE 2181
+D ++ ++ ++ K+ R + +EK+T ++ A + E I + + E+
Sbjct: 2386 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2445
Query: 2182 GGIEEEEVIPFLK----RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL--- 2234
+++E + LK + ++ + + ++ F S+ D + E F E+ ++ L
Sbjct: 2446 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2505
Query: 2235 --DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
DE+ K + L E++ ++++ E+ + V EE R+ + E EE K+EE ++ +++
Sbjct: 2506 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2565
Query: 2293 EKKKEE-VQEKEEVFEEKEEIMSEEETESLSDEEE 2326
+++EE + E+ + E+ +++ E+ +L+ EE
Sbjct: 2566 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2600
Score = 172 bits (436), Expect = 4e-42
Identities = 265/1216 (21%), Positives = 541/1216 (44%), Gaps = 180/1216 (14%)
Query: 1295 KKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEV-MPREEEQAQKK 1353
++E+K L + + +VV E+ + Q+ ++ IQ Q++ + E + + QA+
Sbjct: 1373 EREAKELQQRMQEEVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAEIQAKARQAEAA 1429
Query: 1354 ARDMLGLEETQVILKKGKKVIFLEPGNV----------TMGKEISKKEEKKTFQKSPKQG 1403
R L +EE +++ + + G E K++ ++ ++ +Q
Sbjct: 1430 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1489
Query: 1404 RKAVQKERKVG-------KIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPS 1456
+ Q++R+ K + E +E++ + +EE+ L+ + ++ + +ER
Sbjct: 1490 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR-LQAEEAERRLRQAEVERARQ 1548
Query: 1457 WQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEE----KLHQAGEKLSPEE---EM 1509
Q + + +++++ A K +R LQEE +L + E+ + ++ E
Sbjct: 1549 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1608
Query: 1510 LQEDKKLKWEEW----------KQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
+E+ + + E W + E + KS Q ++++ E E R G+ +EQ
Sbjct: 1609 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1668
Query: 1560 ---------QVTEEQRHIQEEHKWARIHRK----RARAEKKRAQEERKLAQEEEKLAQEE 1606
Q E+QR + E R+ + R RAE ++ +++R+L +EE LA+ +
Sbjct: 1669 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE--LARLQ 1726
Query: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA 1666
R+ A +K + ++ + EM A+ EE EK Q E A + ++LA
Sbjct: 1727 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1786
Query: 1667 KKWEKV------AREEEKLAKKGG--KLAEVKNILAQKV--------------------- 1697
++ ++ A+ + +LA++ + AE + +LA+K+
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1846
Query: 1698 ---EELPQREQNLDWQEKELAQELEELEWDMEE-----LSWKEEELNQEEGKLVEE--KK 1747
E L + ++ +Q + L ++ + + D+EE + EL +++G LVE+ ++
Sbjct: 1847 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG-LVEDTLRQ 1905
Query: 1748 KLAEEEEALAWQ---------REKLSEEETKLAQEEELLIQEKEKL---AQHKEKMPEEE 1795
+ EEE LA + + +L E ++ E ++ KE+ A + ++ EE
Sbjct: 1906 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1965
Query: 1796 ERLGRKREQLIEKKMKLAQKRERWIN-SMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
ER R+ E+ ++K + ++ R ++EE+ + K + + + L + + + + +LA
Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2025
Query: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
Q E H+ V+ K + L Q + L Q + + E E+
Sbjct: 2026 QEAAQKRLQAEEKAHA----FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081
Query: 1915 KLVQVEDSLAKKQ------EKLAQEKMKLALEKAMVQ-GKKRLRGELDIAKEEKALNLEM 1967
VQ E A+ + E+L Q + A +A Q ++LR E A++E A +
Sbjct: 2082 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE---AEQEAARRAQA 2138
Query: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME 2027
++ A + + + + K +T RQ+ QVEQEL +L LEE H+ +L
Sbjct: 2139 EQAALRQKQAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRLQLEETD--HQKNLL--- 2191
Query: 2028 ESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDE 2087
+ E+ + K E T R Q + +L ++ E LSK A++ +AL +D
Sbjct: 2192 DEELQRLKAEATEAARQRSQVEEELFSVRVQM----EELSKLKARIEAENRALILRDKDN 2247
Query: 2088 -RKLTQEEIKMTKMKRALFVKERRLSI---EQSKL-DIKEWDFSEKRS------------ 2130
++ QEE + KMK+ + + RLS+ E ++L + E D +++R+
Sbjct: 2248 TQRFLQEEAE--KMKQ-VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2304
Query: 2131 --ELT--KDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE 2186
E T K E +L ++Q++LA + R + ++++ ++ + + L+ E + +E
Sbjct: 2305 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364
Query: 2187 EEVIPFLKRRWRKRKEAK-RGDKPKEKFSSQVDEVESEEHFSE----EMESLLDELEKQE 2241
LK R + A+ R ++ ++F Q +E+ + H +E E +L+ LE Q
Sbjct: 2365 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ- 2423
Query: 2242 SLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
++ + + ER E + E E E KE+ + E K ++ + EE + ++E+ +E Q
Sbjct: 2424 ------RQQSDHDAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476
Query: 2302 KEEVF-EEKEEIMS-----EEETESLSD--EEEEEESCSLEEEVDREKEILKKEKQ---F 2350
++ F EK+ ++ E+E L ++E ++ L EE R+++ +++E+Q
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536
Query: 2351 KLQEQRRKSLRGRERV 2366
++E RR+ E V
Sbjct: 2537 SMEEARRRQHEAEEGV 2552
Score = 154 bits (390), Expect = 9e-37
Identities = 227/999 (22%), Positives = 433/999 (43%), Gaps = 130/999 (13%)
Query: 1504 SPEEEMLQE--DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE--KEQ 1559
S E ++QE D + + E + + S+ + +EEE E++ + E E + +
Sbjct: 1293 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1352
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL--AQEERQLAQEERKLA 1617
E+QR + E H A+ +R E ++ +E + +EE + Q++R + +E ++L
Sbjct: 1353 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1412
Query: 1618 QAYVKITQDDREMAQAEGKF------------AQKEETLAQRG------EKLSQEAEKLA 1659
Q+ Q A+A + Q E T QRG + L AE+
Sbjct: 1413 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1472
Query: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
++++ ++ E++ R+ + +++ + AEV+ K E RE ++ Q LE
Sbjct: 1473 AQKRQAQEEAERLRRQVQDESQR-KRQAEVELASRVKAEAEAARE------KQRALQALE 1525
Query: 1720 ELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQ 1779
EL EE + + E + V+ + A+ Q ++ S E K AQ E L +
Sbjct: 1526 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQE 1584
Query: 1780 EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW---INSMEELTKNKMILYQK 1836
E +AQ + EE ER +++ + + + ++ ERW N L + Q+
Sbjct: 1585 EHVAVAQ----LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1640
Query: 1837 KNLAQ-EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL--GMFNKILAQVEE 1893
K+LAQ E + +E E+ A+R+ R +Q ++ + +L G + LA +E
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700
Query: 1894 --KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE-KAMVQGKKRL 1950
+L E E ++++ L E +L + + +K+++L E K+ E + ++ K R
Sbjct: 1701 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1760
Query: 1951 RGELDIAKEEKALNLE-----MKRLAEEKMRL-VEGKETLSKGETPETSRQRKMTQVEQE 2004
E E+ LE + LAEE RL +E + + E R+ + E+
Sbjct: 1761 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1820
Query: 2005 LFERKLSLEEKILLHEDRILAMEESEIAKGKL------EFTRGQRIFVQGQRKLAKASRK 2058
L E+ ++ E L + +A++E E +L E + +R+ Q + A +
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880
Query: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEI---KMTKMKRALFVKERRLSIEQ 2115
L + R++ E + K L + T +R+ +EEI K + K A E L + +
Sbjct: 1881 LAQLRKASDSELER----QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936
Query: 2116 SKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM-----TEEESKLARK 2170
+ + ++ S++++EL + AR+++ A + RR EE++ EEE+ RK
Sbjct: 1937 IRSNAEDTLRSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1991
Query: 2171 HSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK----------------RGDKPKEKFS 2214
L++ E + EE RR R+R E + + ++ F+
Sbjct: 1992 ---AALEEVERLKAKVEEA-----RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043
Query: 2215 SQVDEVESEEHFSEEMESLLDELEKQESL---SSEEEEEREEEEEREEEEVREEEEERKE 2271
Q E E ++ +E +S+LD+L + ++EE EE + ERE + R + EE +
Sbjct: 2044 VQQKEQELQQTLQQE-QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2102
Query: 2272 EEEGEEKQVE-------------KEEEEKKKKKKEKKKEEVQEK--------------EE 2304
++ E+Q + KE E++ ++ + ++ +++K E+
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK-EILKKEKQFKLQEQRRKSLRGR 2363
+K ++ E T L EE + + L+EE+ R K E + +Q E+ S+R +
Sbjct: 2163 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
LS L+ + RA+ L + + L A +MK+
Sbjct: 2223 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2261
Score = 122 bits (305), Expect = 7e-27
Identities = 196/962 (20%), Positives = 399/962 (41%), Gaps = 153/962 (15%)
Query: 1536 QQYKDEEEVTLEEEVSREGEEKEQ------QVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589
QQ E +V +E R + E+ Q QR +++ + R +R+ A
Sbjct: 1150 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1209
Query: 1590 QEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE 1649
Q+ R+ ++ + + + Q +E+ + QA + E + + GE
Sbjct: 1210 QDARRRQEQIQAMPLADSQAVREQLRQEQALL--------------------EEIERHGE 1249
Query: 1650 KLSQEAEKLAQKRKKLAKKWE------KVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
K+ +E ++ A++ K +E K E K K+ + Q+ +L
Sbjct: 1250 KV-EECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1308
Query: 1704 EQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQRE-- 1761
L + + + E MEE EE L +++ EE+++LAE E AL QR+
Sbjct: 1309 YSELTTLTSQYIKFISETLRRMEE----EERLAEQQR--AEERERLAEVEAALEKQRQLA 1362
Query: 1762 -------KLSEEETKLAQ---EEELLIQEKEKL--AQHKEKMPEEEERLGRKREQLIEKK 1809
+E E K Q +EE++ +E+ + Q K + EE ++L + E I+ K
Sbjct: 1363 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1422
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
+ A+ ER +EE + +++ Q + +++ E + L R E K +
Sbjct: 1423 ARQAEAAERSRLRIEE--EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1480
Query: 1870 SKKQL-VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS--LAKK 1926
++L QV+++ + ++ ++ E E +K+ L E+ +Q E++ ++
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1540
Query: 1927 QEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSK 1986
E ++++ALE A + L+ + + EK LE + L EE + + + +E +
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSK-RASFAEKTAQLE-RSLQEEHVAVAQLREEAER 1598
Query: 1987 GETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046
+ +R + E+EL +L E + L ++ +A+ + E + +
Sbjct: 1599 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--E 1656
Query: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKI--------LKALQKLTR---------DERK 2089
+ R+ KA + +++RE +E K ++ L A Q+L R +R+
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1716
Query: 2090 LTQEEI-KMTKMKRALFVKERRLSIEQSK--------LDIKEWDFSEKRSELTKDEKKL- 2139
L +EE+ ++ + A K + L E +K L K E RS K +++L
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1776
Query: 2140 --ARKQRKLANKMRRM------INKEEKMTEEESKLARKHSEVILDD------------- 2178
A + R+LA + R+ ++ ++ EE++ R +E +L +
Sbjct: 1777 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1836
Query: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELE 2238
E E ++E+E R R+ E + + + + + + + EE ++ ++ ELE
Sbjct: 1837 EAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1893
Query: 2239 KQESLSSEEEEEREEEEE--------------------------REEEEVREEEEERKEE 2272
+Q+ L + +R + EE R E +E+ E
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1953
Query: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE--------EETESLSDE 2324
E ++Q+ EEE ++++ +E+ ++ + +EE +++ + E EE L +
Sbjct: 1954 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2013
Query: 2325 EEEEESCSL---EEEVDREKEILKKEKQFKLQEQR---RKSLRGRERVLSILRGVPHGKG 2378
E+E + L +E + + +K F +Q++ +++L+ + VL LRG
Sbjct: 2014 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2073
Query: 2379 RA 2380
RA
Sbjct: 2074 RA 2075
Score = 54.7 bits (130), Expect = 1e-06
Identities = 115/578 (19%), Positives = 227/578 (39%), Gaps = 88/578 (15%)
Query: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
+L +KE + +++AE +K +VE L K +L+ E K+ LR E
Sbjct: 994 RLPLDKEPARECAQRIAEQQKAQAEVE-GLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1052
Query: 1954 LDIA-------KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
L++ + A+ LE + +R +G E + + + + + EL
Sbjct: 1053 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1112
Query: 2007 ERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRG-QRIFVQGQRKLAKASRKLIKKRES 2065
K SL++ R A + + RG Q + + Q++ + ++ + RE
Sbjct: 1113 ATKASLKKL------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1166
Query: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD-IKEWD 2124
++ Q L R + L Q +++ ++++ R+L + D + W
Sbjct: 1167 VA-------------QLLERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWL 1209
Query: 2125 FSEKRSE-----LTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE 2179
+R + + + + R+Q + + I + + EE + A+++ I D E
Sbjct: 1210 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1269
Query: 2180 EEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQV---DEVESEEHFSEEMESLLDE 2236
+ + ++ P A KPK + S+ + V+ H+SE L
Sbjct: 1270 LQLVTYKAQLEPV----------ASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTT 1314
Query: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
L Q E R EEEER E++ EE++ E E +K+++ +
Sbjct: 1315 LTSQYIKFISETLRRMEEEER-----------LAEQQRAEERERLAEVEAALEKQRQLAE 1363
Query: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEE----EEEESCSLEEEVDR-----EKEILKKE 2347
Q K + E +E+ + E + EE +++ S++EE+ + E EI K
Sbjct: 1364 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1423
Query: 2348 KQFKLQEQRRKSLRGRERVLSI-------LRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
+Q + E+ R + RV+ + RG G+ +A+R ++ +K A E
Sbjct: 1424 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK--RQAQEE 1481
Query: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKERE 2438
E+ V ++ + K+ VE+ + + RE
Sbjct: 1482 AERLRRQVQDES---QRKRQAEVELASRVKAEAEAARE 1516
Score = 38.5 bits (88), Expect = 0.097
Identities = 117/632 (18%), Positives = 251/632 (39%), Gaps = 128/632 (20%)
Query: 979 AEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENL 1038
AE+ H + + L QK + +E+ + E DH + +LQ L + + +
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210
Query: 1039 TLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLR 1098
+ E+ FS+ V M E S LK +E + ++ K ++Q++L
Sbjct: 2211 QV----EEELFSVRVQM--EELSKLKARIEAENRALILRD-----------KDNTQRFL- 2252
Query: 1099 GLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEK 1158
+ + KQ++ E L + A ++ E + Q + + ++K
Sbjct: 2253 ---QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------- 2299
Query: 1159 DISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKK 1218
+++Q +++ KA A+ L+++ + ++A+ + E+ ++ + ++
Sbjct: 2300 -----------EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQ 2342
Query: 1219 VKIQGRG-ASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEML 1277
+ + +G + R + S+ + L +L +S +Q + E+ AQ
Sbjct: 2343 LAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMSRAQARAEED--------AQRF- 2392
Query: 1278 VDRHPSWELFQEI--CPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQE 1335
R + E+ +++ L +E L++ L+ I Q+ + ++ E
Sbjct: 2393 --RKQAEEIGEKLHRTELATQEKVTLVQTLE----------IQRQQSDHDAERLREAIAE 2440
Query: 1336 VIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKT 1395
+ R KE + +E + Q K+ +M +++ Q++ + T + S EK +
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-------------TQALQQSFLSEKDS 2487
Query: 1396 FQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455
+Q+ER I++E K E+ +EV + L E+ +Q+
Sbjct: 2488 L----------LQRER---FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---------- 2524
Query: 1456 SWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKK 1515
Q + R+ A EE +R + EE + + E+L E+ ++ ++
Sbjct: 2525 -------------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2571
Query: 1516 LKWEEWKQVWENM-LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTE-EQRHIQEEHK 1573
L EE +++ E + L + EEVT + + + + + + EH
Sbjct: 2572 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2631
Query: 1574 WARIHRKRARAEKKRAQEERKLAQEE-EKLAQ 1604
+ + RK +R QE L+ EE ++LAQ
Sbjct: 2632 FDGLRRK---VSAQRLQEAGILSAEELQRLAQ 2660
Score = 35.0 bits (79), Expect = 1.1
Identities = 95/488 (19%), Positives = 188/488 (38%), Gaps = 76/488 (15%)
Query: 1407 VQKERKVGKIKREMTKEERDMS-------EEVEEMATLEEKVVKQEGKLV-MIERTPSWQ 1458
V ++ + + + + ERD+ E+V+ E+ ++ L + R P Q
Sbjct: 196 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 255
Query: 1459 DWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG--EKLSPEEEMLQEDKKL 1516
D +A E + W+ ++E LL + + H A E+ P E+ ++
Sbjct: 256 DGVRA--------NELQLRWQEYREL--VLLLLQWMRHHTAAFEERRFPSSF---EEIEI 302
Query: 1517 KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWAR 1576
W ++ + E L +K ++ +LE V + + +V + E +W +
Sbjct: 303 LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAV----QAGQLKVPPGYHPLDVEKEWGK 358
Query: 1577 IHRKRARAEKK-RAQEER---------KLAQE----EEKLAQEERQLAQEERKLAQAYV- 1621
+H EK+ R++ ER KL E EE+L Q + L + R LA V
Sbjct: 359 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 418
Query: 1622 -KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
+ + +R++ +A+ + + + E++ ++ +L ++ + R E L
Sbjct: 419 QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI-RTEYNLR 477
Query: 1681 KKGGKLA---EVKNILAQKVEELPQREQN--------LDWQEKELAQELEELEWDMEELS 1729
K G A +V + Q V+ P+ E + L W E E ++ EW + +L
Sbjct: 478 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE-ENQHRVDGAEWGV-DLP 535
Query: 1730 WKEEELNQEEG--KLVEEKKKLAEEEEALAWQRE------------KLSEEETKLAQEEE 1775
E +L G + +EE + E + Q +L + KL +
Sbjct: 536 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 595
Query: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLI-----EKKMKLAQKRERWINSMEELTKNK 1830
++ E L +E L K E+ + ++ + K+E + M EL +
Sbjct: 596 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 655
Query: 1831 MILYQKKN 1838
+ + +N
Sbjct: 656 KKIKELQN 663
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 189 bits (479), Expect = 4e-47
Identities = 268/1295 (20%), Positives = 575/1295 (44%), Gaps = 145/1295 (11%)
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETT 1207
+L++ ++E++ + A K+ Q KA A++ K+ +++ +E V EE
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435
Query: 1208 PPVMEQPVTKKVKIQGRGASG-----ISGRRSTAGDGSSWR-DDLCRLMALRISGSQTKM 1261
+Q + + ++Q S R++ A + S R ++ R++ L++ ++ +
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1495
Query: 1262 --SENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFI 1319
+E L A+E + + E + + ++ ES+ +V +
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKAEA 1552
Query: 1320 QEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDM-LGLEETQVILK---KGKKVIF 1375
+ ++ +Q + + ++ +E R + ++AR + + LE Q + + K+ F
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1612
Query: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMA 1435
E T E S +EE + ++ + Q++ + + + E +E + E
Sbjct: 1613 AEK---TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669
Query: 1436 TL--EEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
L + + V Q+ L E A + ++ E R+ KA ++ +R L E+
Sbjct: 1670 RLRLQAEEVAQQKSLAQAE----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719
Query: 1494 EKLHQ-------AGEKLSPEEEMLQ-EDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVT 1545
E Q A ++L+ E+E+++ + + E+ +Q+ E L+ +E ++
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779
Query: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-------RKLAQE 1598
LE E+++ E E + + R +E + ++R AE R +E R LA+E
Sbjct: 1780 LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1839
Query: 1599 ---EEKLAQEE--RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
+ +LA+E+ RQ A+ ER LA+ I + R +AE +KE E+L +
Sbjct: 1840 AKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA----ENERLRR 1895
Query: 1654 EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE 1713
AE A +R++L E+ A+ + + ++ LA+++ ++E ++ Q ++
Sbjct: 1896 LAEDEAFQRRRLE---EQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQ 1949
Query: 1714 LAQELEELEWDMEELSWKEEELNQEEGKL---VEEKKKLAEEEEALAWQREKLSEEETKL 1770
+ +E+ L+ E+ + + EL E G++ E+ + E+ E A ++ +L+ EE +
Sbjct: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009
Query: 1771 AQEEELLIQE----KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL 1826
+E E +Q+ +E+ A+ ++ EE ERL K E+ + + Q+ R + +E
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
Query: 1827 TKNKMILYQKKNL--AQEKKN-----LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKN 1879
+ ++ +K + Q+K+ L QE+ L Q + + +++ VQ +
Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2129
Query: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKK-QEKLAQEKMKLA 1938
+ + + + E +E + + A EK + E A++ Q + A + K A
Sbjct: 2130 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189
Query: 1939 LEKAMVQGKK----RLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSR 1994
+ M + KK LR + + +E L L+++ +K L E + L K E E +R
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL-KAEATEAAR 2248
Query: 1995 QRKMTQVEQELFERKLSLEEK--------------ILLHEDRILAMEESEIAKGKLEFTR 2040
QR +QVE+ELF ++ +EE IL +D + E K K
Sbjct: 2249 QR--SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306
Query: 2041 GQRIFVQGQ-----RKLAKA--------SRKLIKKRESLSKEPAKLNKILKALQ------ 2081
R+ V Q R+LA+ + K++K++ +E +L + LQ
Sbjct: 2307 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2366
Query: 2082 -----KLTRDERKLTQEEIKMTK-MKRALFVKERR---LSIEQSKLDIKEWDFSEKRSEL 2132
+L D+ ++ Q+ + T+ +R L + +R +S E +L ++ + S ++
Sbjct: 2367 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2426
Query: 2133 TKDEKKLARKQRKLANKMRRM-INKEEKMT---------EEESKLARKHSEVILD-DEEE 2181
+D ++ ++ ++ K+ R + +EK+T ++ A + E I + + E+
Sbjct: 2427 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2486
Query: 2182 GGIEEEEVIPFLK----RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL--- 2234
+++E + LK + ++ + + ++ F S+ D + E F E+ ++ L
Sbjct: 2487 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2546
Query: 2235 --DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
DE+ K + L E++ ++++ E+ + V EE R+ + E EE K+EE ++ +++
Sbjct: 2547 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2606
Query: 2293 EKKKEE-VQEKEEVFEEKEEIMSEEETESLSDEEE 2326
+++EE + E+ + E+ +++ E+ +L+ EE
Sbjct: 2607 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2641
Score = 172 bits (436), Expect = 4e-42
Identities = 265/1216 (21%), Positives = 541/1216 (44%), Gaps = 180/1216 (14%)
Query: 1295 KKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEV-MPREEEQAQKK 1353
++E+K L + + +VV E+ + Q+ ++ IQ Q++ + E + + QA+
Sbjct: 1414 EREAKELQQRMQEEVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAEIQAKARQAEAA 1470
Query: 1354 ARDMLGLEETQVILKKGKKVIFLEPGNV----------TMGKEISKKEEKKTFQKSPKQG 1403
R L +EE +++ + + G E K++ ++ ++ +Q
Sbjct: 1471 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1530
Query: 1404 RKAVQKERKVG-------KIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPS 1456
+ Q++R+ K + E +E++ + +EE+ L+ + ++ + +ER
Sbjct: 1531 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR-LQAEEAERRLRQAEVERARQ 1589
Query: 1457 WQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEE----KLHQAGEKLSPEE---EM 1509
Q + + +++++ A K +R LQEE +L + E+ + ++ E
Sbjct: 1590 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1649
Query: 1510 LQEDKKLKWEEW----------KQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
+E+ + + E W + E + KS Q ++++ E E R G+ +EQ
Sbjct: 1650 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1709
Query: 1560 ---------QVTEEQRHIQEEHKWARIHRK----RARAEKKRAQEERKLAQEEEKLAQEE 1606
Q E+QR + E R+ + R RAE ++ +++R+L +EE LA+ +
Sbjct: 1710 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE--LARLQ 1767
Query: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA 1666
R+ A +K + ++ + EM A+ EE EK Q E A + ++LA
Sbjct: 1768 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1827
Query: 1667 KKWEKV------AREEEKLAKKGG--KLAEVKNILAQKV--------------------- 1697
++ ++ A+ + +LA++ + AE + +LA+K+
Sbjct: 1828 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1887
Query: 1698 ---EELPQREQNLDWQEKELAQELEELEWDMEE-----LSWKEEELNQEEGKLVEE--KK 1747
E L + ++ +Q + L ++ + + D+EE + EL +++G LVE+ ++
Sbjct: 1888 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG-LVEDTLRQ 1946
Query: 1748 KLAEEEEALAWQ---------REKLSEEETKLAQEEELLIQEKEKL---AQHKEKMPEEE 1795
+ EEE LA + + +L E ++ E ++ KE+ A + ++ EE
Sbjct: 1947 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2006
Query: 1796 ERLGRKREQLIEKKMKLAQKRERWIN-SMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
ER R+ E+ ++K + ++ R ++EE+ + K + + + L + + + + +LA
Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2066
Query: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
Q E H+ V+ K + L Q + L Q + + E E+
Sbjct: 2067 QEAAQKRLQAEEKAHA----FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
Query: 1915 KLVQVEDSLAKKQ------EKLAQEKMKLALEKAMVQ-GKKRLRGELDIAKEEKALNLEM 1967
VQ E A+ + E+L Q + A +A Q ++LR E A++E A +
Sbjct: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE---AEQEAARRAQA 2179
Query: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME 2027
++ A + + + + K +T RQ+ QVEQEL +L LEE H+ +L
Sbjct: 2180 EQAALRQKQAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRLQLEETD--HQKNLL--- 2232
Query: 2028 ESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDE 2087
+ E+ + K E T R Q + +L ++ E LSK A++ +AL +D
Sbjct: 2233 DEELQRLKAEATEAARQRSQVEEELFSVRVQM----EELSKLKARIEAENRALILRDKDN 2288
Query: 2088 -RKLTQEEIKMTKMKRALFVKERRLSI---EQSKL-DIKEWDFSEKRS------------ 2130
++ QEE + KMK+ + + RLS+ E ++L + E D +++R+
Sbjct: 2289 TQRFLQEEAE--KMKQ-VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2345
Query: 2131 --ELT--KDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE 2186
E T K E +L ++Q++LA + R + ++++ ++ + + L+ E + +E
Sbjct: 2346 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405
Query: 2187 EEVIPFLKRRWRKRKEAK-RGDKPKEKFSSQVDEVESEEHFSE----EMESLLDELEKQE 2241
LK R + A+ R ++ ++F Q +E+ + H +E E +L+ LE Q
Sbjct: 2406 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ- 2464
Query: 2242 SLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
++ + + ER E + E E E KE+ + E K ++ + EE + ++E+ +E Q
Sbjct: 2465 ------RQQSDHDAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 2302 KEEVF-EEKEEIMS-----EEETESLSD--EEEEEESCSLEEEVDREKEILKKEKQ---F 2350
++ F EK+ ++ E+E L ++E ++ L EE R+++ +++E+Q
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577
Query: 2351 KLQEQRRKSLRGRERV 2366
++E RR+ E V
Sbjct: 2578 SMEEARRRQHEAEEGV 2593
Score = 154 bits (390), Expect = 9e-37
Identities = 227/999 (22%), Positives = 433/999 (43%), Gaps = 130/999 (13%)
Query: 1504 SPEEEMLQE--DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE--KEQ 1559
S E ++QE D + + E + + S+ + +EEE E++ + E E + +
Sbjct: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL--AQEERQLAQEERKLA 1617
E+QR + E H A+ +R E ++ +E + +EE + Q++R + +E ++L
Sbjct: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1453
Query: 1618 QAYVKITQDDREMAQAEGKF------------AQKEETLAQRG------EKLSQEAEKLA 1659
Q+ Q A+A + Q E T QRG + L AE+
Sbjct: 1454 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1513
Query: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
++++ ++ E++ R+ + +++ + AEV+ K E RE ++ Q LE
Sbjct: 1514 AQKRQAQEEAERLRRQVQDESQR-KRQAEVELASRVKAEAEAARE------KQRALQALE 1566
Query: 1720 ELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQ 1779
EL EE + + E + V+ + A+ Q ++ S E K AQ E L +
Sbjct: 1567 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQE 1625
Query: 1780 EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW---INSMEELTKNKMILYQK 1836
E +AQ + EE ER +++ + + + ++ ERW N L + Q+
Sbjct: 1626 EHVAVAQ----LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 1837 KNLAQ-EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL--GMFNKILAQVEE 1893
K+LAQ E + +E E+ A+R+ R +Q ++ + +L G + LA +E
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
Query: 1894 --KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE-KAMVQGKKRL 1950
+L E E ++++ L E +L + + +K+++L E K+ E + ++ K R
Sbjct: 1742 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1801
Query: 1951 RGELDIAKEEKALNLE-----MKRLAEEKMRL-VEGKETLSKGETPETSRQRKMTQVEQE 2004
E E+ LE + LAEE RL +E + + E R+ + E+
Sbjct: 1802 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861
Query: 2005 LFERKLSLEEKILLHEDRILAMEESEIAKGKL------EFTRGQRIFVQGQRKLAKASRK 2058
L E+ ++ E L + +A++E E +L E + +R+ Q + A +
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921
Query: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEI---KMTKMKRALFVKERRLSIEQ 2115
L + R++ E + K L + T +R+ +EEI K + K A E L + +
Sbjct: 1922 LAQLRKASDSELER----QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
Query: 2116 SKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM-----TEEESKLARK 2170
+ + ++ S++++EL + AR+++ A + RR EE++ EEE+ RK
Sbjct: 1978 IRSNAEDTLRSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2032
Query: 2171 HSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK----------------RGDKPKEKFS 2214
L++ E + EE RR R+R E + + ++ F+
Sbjct: 2033 ---AALEEVERLKAKVEEA-----RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084
Query: 2215 SQVDEVESEEHFSEEMESLLDELEKQESL---SSEEEEEREEEEEREEEEVREEEEERKE 2271
Q E E ++ +E +S+LD+L + ++EE EE + ERE + R + EE +
Sbjct: 2085 VQQKEQELQQTLQQE-QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2143
Query: 2272 EEEGEEKQVE-------------KEEEEKKKKKKEKKKEEVQEK--------------EE 2304
++ E+Q + KE E++ ++ + ++ +++K E+
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK-EILKKEKQFKLQEQRRKSLRGR 2363
+K ++ E T L EE + + L+EE+ R K E + +Q E+ S+R +
Sbjct: 2204 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263
Query: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
LS L+ + RA+ L + + L A +MK+
Sbjct: 2264 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2302
Score = 122 bits (305), Expect = 7e-27
Identities = 196/962 (20%), Positives = 399/962 (41%), Gaps = 153/962 (15%)
Query: 1536 QQYKDEEEVTLEEEVSREGEEKEQ------QVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589
QQ E +V +E R + E+ Q QR +++ + R +R+ A
Sbjct: 1191 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1250
Query: 1590 QEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE 1649
Q+ R+ ++ + + + Q +E+ + QA + E + + GE
Sbjct: 1251 QDARRRQEQIQAMPLADSQAVREQLRQEQALL--------------------EEIERHGE 1290
Query: 1650 KLSQEAEKLAQKRKKLAKKWE------KVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
K+ +E ++ A++ K +E K E K K+ + Q+ +L
Sbjct: 1291 KV-EECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349
Query: 1704 EQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQRE-- 1761
L + + + E MEE EE L +++ EE+++LAE E AL QR+
Sbjct: 1350 YSELTTLTSQYIKFISETLRRMEE----EERLAEQQR--AEERERLAEVEAALEKQRQLA 1403
Query: 1762 -------KLSEEETKLAQ---EEELLIQEKEKL--AQHKEKMPEEEERLGRKREQLIEKK 1809
+E E K Q +EE++ +E+ + Q K + EE ++L + E I+ K
Sbjct: 1404 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1463
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
+ A+ ER +EE + +++ Q + +++ E + L R E K +
Sbjct: 1464 ARQAEAAERSRLRIEE--EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1521
Query: 1870 SKKQL-VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS--LAKK 1926
++L QV+++ + ++ ++ E E +K+ L E+ +Q E++ ++
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1581
Query: 1927 QEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSK 1986
E ++++ALE A + L+ + + EK LE + L EE + + + +E +
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSK-RASFAEKTAQLE-RSLQEEHVAVAQLREEAER 1639
Query: 1987 GETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046
+ +R + E+EL +L E + L ++ +A+ + E + +
Sbjct: 1640 RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--E 1697
Query: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKI--------LKALQKLTR---------DERK 2089
+ R+ KA + +++RE +E K ++ L A Q+L R +R+
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757
Query: 2090 LTQEEI-KMTKMKRALFVKERRLSIEQSK--------LDIKEWDFSEKRSELTKDEKKL- 2139
L +EE+ ++ + A K + L E +K L K E RS K +++L
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1817
Query: 2140 --ARKQRKLANKMRRM------INKEEKMTEEESKLARKHSEVILDD------------- 2178
A + R+LA + R+ ++ ++ EE++ R +E +L +
Sbjct: 1818 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1877
Query: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELE 2238
E E ++E+E R R+ E + + + + + + + EE ++ ++ ELE
Sbjct: 1878 EAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1934
Query: 2239 KQESLSSEEEEEREEEEE--------------------------REEEEVREEEEERKEE 2272
+Q+ L + +R + EE R E +E+ E
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994
Query: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE--------EETESLSDE 2324
E ++Q+ EEE ++++ +E+ ++ + +EE +++ + E EE L +
Sbjct: 1995 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2054
Query: 2325 EEEEESCSL---EEEVDREKEILKKEKQFKLQEQR---RKSLRGRERVLSILRGVPHGKG 2378
E+E + L +E + + +K F +Q++ +++L+ + VL LRG
Sbjct: 2055 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114
Query: 2379 RA 2380
RA
Sbjct: 2115 RA 2116
Score = 54.7 bits (130), Expect = 1e-06
Identities = 115/578 (19%), Positives = 227/578 (39%), Gaps = 88/578 (15%)
Query: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
+L +KE + +++AE +K +VE L K +L+ E K+ LR E
Sbjct: 1035 RLPLDKEPARECAQRIAEQQKAQAEVE-GLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1093
Query: 1954 LDIA-------KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
L++ + A+ LE + +R +G E + + + + + EL
Sbjct: 1094 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1153
Query: 2007 ERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRG-QRIFVQGQRKLAKASRKLIKKRES 2065
K SL++ R A + + RG Q + + Q++ + ++ + RE
Sbjct: 1154 ATKASLKKL------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1207
Query: 2066 LSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD-IKEWD 2124
++ Q L R + L Q +++ ++++ R+L + D + W
Sbjct: 1208 VA-------------QLLERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWL 1250
Query: 2125 FSEKRSE-----LTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE 2179
+R + + + + R+Q + + I + + EE + A+++ I D E
Sbjct: 1251 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1310
Query: 2180 EEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQV---DEVESEEHFSEEMESLLDE 2236
+ + ++ P A KPK + S+ + V+ H+SE L
Sbjct: 1311 LQLVTYKAQLEPV----------ASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTT 1355
Query: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
L Q E R EEEER E++ EE++ E E +K+++ +
Sbjct: 1356 LTSQYIKFISETLRRMEEEER-----------LAEQQRAEERERLAEVEAALEKQRQLAE 1404
Query: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEE----EEEESCSLEEEVDR-----EKEILKKE 2347
Q K + E +E+ + E + EE +++ S++EE+ + E EI K
Sbjct: 1405 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1464
Query: 2348 KQFKLQEQRRKSLRGRERVLSI-------LRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
+Q + E+ R + RV+ + RG G+ +A+R ++ +K A E
Sbjct: 1465 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK--RQAQEE 1522
Query: 2401 KEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKERE 2438
E+ V ++ + K+ VE+ + + RE
Sbjct: 1523 AERLRRQVQDES---QRKRQAEVELASRVKAEAEAARE 1557
Score = 38.5 bits (88), Expect = 0.097
Identities = 117/632 (18%), Positives = 251/632 (39%), Gaps = 128/632 (20%)
Query: 979 AEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENL 1038
AE+ H + + L QK + +E+ + E DH + +LQ L + + +
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251
Query: 1039 TLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLR 1098
+ E+ FS+ V M E S LK +E + ++ K ++Q++L
Sbjct: 2252 QV----EEELFSVRVQM--EELSKLKARIEAENRALILRD-----------KDNTQRFL- 2293
Query: 1099 GLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEK 1158
+ + KQ++ E L + A ++ E + Q + + ++K
Sbjct: 2294 ---QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------- 2340
Query: 1159 DISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKK 1218
+++Q +++ KA A+ L+++ + ++A+ + E+ ++ + ++
Sbjct: 2341 -----------EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED------KEQMAQQ 2383
Query: 1219 VKIQGRG-ASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEML 1277
+ + +G + R + S+ + L +L +S +Q + E+ AQ
Sbjct: 2384 LAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMSRAQARAEED--------AQRF- 2433
Query: 1278 VDRHPSWELFQEI--CPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQE 1335
R + E+ +++ L +E L++ L+ I Q+ + ++ E
Sbjct: 2434 --RKQAEEIGEKLHRTELATQEKVTLVQTLE----------IQRQQSDHDAERLREAIAE 2481
Query: 1336 VIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKT 1395
+ R KE + +E + Q K+ +M +++ Q++ + T + S EK +
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-------------TQALQQSFLSEKDS 2528
Query: 1396 FQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455
+Q+ER I++E K E+ +EV + L E+ +Q+
Sbjct: 2529 L----------LQRER---FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---------- 2565
Query: 1456 SWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKK 1515
Q + R+ A EE +R + EE + + E+L E+ ++ ++
Sbjct: 2566 -------------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2612
Query: 1516 LKWEEWKQVWENM-LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTE-EQRHIQEEHK 1573
L EE +++ E + L + EEVT + + + + + + EH
Sbjct: 2613 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2672
Query: 1574 WARIHRKRARAEKKRAQEERKLAQEE-EKLAQ 1604
+ + RK +R QE L+ EE ++LAQ
Sbjct: 2673 FDGLRRK---VSAQRLQEAGILSAEELQRLAQ 2701
Score = 35.0 bits (79), Expect = 1.1
Identities = 95/488 (19%), Positives = 188/488 (38%), Gaps = 76/488 (15%)
Query: 1407 VQKERKVGKIKREMTKEERDMS-------EEVEEMATLEEKVVKQEGKLV-MIERTPSWQ 1458
V ++ + + + + ERD+ E+V+ E+ ++ L + R P Q
Sbjct: 237 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 296
Query: 1459 DWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG--EKLSPEEEMLQEDKKL 1516
D +A E + W+ ++E LL + + H A E+ P E+ ++
Sbjct: 297 DGVRA--------NELQLRWQEYREL--VLLLLQWMRHHTAAFEERRFPSSF---EEIEI 343
Query: 1517 KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWAR 1576
W ++ + E L +K ++ +LE V + + +V + E +W +
Sbjct: 344 LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAV----QAGQLKVPPGYHPLDVEKEWGK 399
Query: 1577 IHRKRARAEKK-RAQEER---------KLAQE----EEKLAQEERQLAQEERKLAQAYV- 1621
+H EK+ R++ ER KL E EE+L Q + L + R LA V
Sbjct: 400 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 459
Query: 1622 -KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
+ + +R++ +A+ + + + E++ ++ +L ++ + R E L
Sbjct: 460 QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI-RTEYNLR 518
Query: 1681 KKGGKLA---EVKNILAQKVEELPQREQN--------LDWQEKELAQELEELEWDMEELS 1729
K G A +V + Q V+ P+ E + L W E E ++ EW + +L
Sbjct: 519 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE-ENQHRVDGAEWGV-DLP 576
Query: 1730 WKEEELNQEEG--KLVEEKKKLAEEEEALAWQRE------------KLSEEETKLAQEEE 1775
E +L G + +EE + E + Q +L + KL +
Sbjct: 577 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 636
Query: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLI-----EKKMKLAQKRERWINSMEELTKNK 1830
++ E L +E L K E+ + ++ + K+E + M EL +
Sbjct: 637 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 696
Query: 1831 MILYQKKN 1838
+ + +N
Sbjct: 697 KKIKELQN 704
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 183 bits (464), Expect = 2e-45
Identities = 110/449 (24%), Positives = 259/449 (57%), Gaps = 20/449 (4%)
Query: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE-EEVTLEEEVSREGEEKEQ 1559
E+L + LQE +L E ++ N+ K K ++ K + L+ E G+E +
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 276
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQA 1619
+ Q ++E W R+++++ E+K ++E K+ + EEK+ ++E ++ ++E K+ +
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQ---EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 1620 YVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKL 1679
K+ + + M + E K ++EE + ++ EK+ + E + +K +K+ + EK+ E+EK+
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKM-HEQEKI 392
Query: 1680 AKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEE 1739
++ K E + I Q E Q ++ W+++E +E EE + E+ W++EE E+
Sbjct: 393 REQEEKRQEEEKIREQ---EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 449
Query: 1740 GKLVEEKKKLAEEE-----------EALAWQREKLSEEETKLAQEEELLIQEKEKLAQHK 1788
K+ EE+K+ +EE E + Q+EK+ E+E K+ ++EE + +++EK+ +
Sbjct: 450 EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQE-KIRKQEEKVWRQEEKMHDQE 508
Query: 1789 EKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQ 1848
EK+ E+EE++ R+ E++ E++ K+ ++ E+ E + + + + +++ QE++ + +
Sbjct: 509 EKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRR 568
Query: 1849 EKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEK 1908
++EK+ +++E + KE++ ++++ + + K+ +++ + EEK+ +++E + +++EK
Sbjct: 569 QEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 628
Query: 1909 LAETEKKLVQVEDSLAKKQEKLAQEKMKL 1937
+ E E+K+ + E+ + +++ +L Q++ K+
Sbjct: 629 MQEQEEKMRRQEEKMWEQEVRLRQQEEKM 657
Score = 174 bits (441), Expect = 1e-42
Identities = 127/500 (25%), Positives = 273/500 (54%), Gaps = 46/500 (9%)
Query: 1351 QKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKE 1410
QKK D +EE L K + + LE T+ E K++ K +K + + +
Sbjct: 187 QKKKADRY-IEE----LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ 241
Query: 1411 RKVGKIKREMTKEERDMSEEV--EEMATLEEKVVKQEGKL-VMIERTPSWQDWKKAWDEW 1467
V ++KR++ + + + ++ E L +++ KL +E W + +E
Sbjct: 242 LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE- 300
Query: 1468 KQVHGETRKSWKAWK--EEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVW 1525
K W+ + +EWE+++ ++EEK+ + EK+ +EE ++ +++ WE+ +++
Sbjct: 301 --------KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
Query: 1526 ENMLSSKSKEQQYKDEEEVTLE-EEVSREGEEK--EQQVTEEQRHIQEEHKWARIHRKRA 1582
KE++ + EE+ E EE RE EEK EQ+ EQ ++E + R KR
Sbjct: 353 RQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 412
Query: 1583 RAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDR-----EMAQAEGKF 1637
E K ++E K+ ++EEK+ ++E+++ ++E K+ + KI ++++ EM + E K
Sbjct: 413 EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE-KIREEEKRQEQEEMWRQEEKI 471
Query: 1638 AQKEETLAQRG-----EKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNI 1692
++EE Q+ EK+ ++ EK+ ++ +K+ + EK+ +EEK+ ++ K+ E +
Sbjct: 472 REQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEK 531
Query: 1693 LAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEE 1752
+ ++ E++ ++E+ + QE+++ ++ E+++ + E++ +EE++ ++E K+ E+K+K+ E+
Sbjct: 532 IREQEEKIREQEEMMQEQEEKMGEQEEKMQ-EQEKMRRQEEKIREQEEKIREQKEKIREQ 590
Query: 1753 EEALAWQREKLSEEETKLAQEEELLIQEKEKLA------QHKEKMPEEEERLGRKREQLI 1806
EE + Q EK+ E+E + ++EE + +++EK+ Q E+EE++ R+ E++
Sbjct: 591 EEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ------EQEEKMRRQEEKMW 644
Query: 1807 EKKMKLAQKRERWINSMEEL 1826
E++++L Q+ E+ E L
Sbjct: 645 EQEVRLRQQEEKMQEHQEHL 664
Score = 165 bits (417), Expect = 7e-40
Identities = 130/506 (25%), Positives = 261/506 (51%), Gaps = 75/506 (14%)
Query: 1294 LKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKK 1353
LK+++ L E L +V EK I + ++ + +++ R K ++P+++ QA+
Sbjct: 219 LKEKNAKLQEKLQ--LVESEKSEIQLN--------VKELKRKLERAKLLLPQQQLQAEA- 267
Query: 1354 ARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISK---KEEK--KTFQKSPKQGRKAVQ 1408
D LG E V K +V E N ++ K +EEK + +K +Q K +
Sbjct: 268 --DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325
Query: 1409 KERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWK 1468
+E K+ + + +M ++E M E+ E+M EE + ++E K+ +E W+ +K + +
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEM-MWEKEEKIRELEE 384
Query: 1469 QVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG------EKLSPEEEMLQEDKKLKWEEWK 1522
++H + + + K + E+++ ++E++ Q EK+ +EE ++E +K W + +
Sbjct: 385 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 444
Query: 1523 QVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE----KEQQVTEEQRHIQEEHKWARIH 1578
++ E +E++ +++EE+ +EE RE EE KE+ +E+ QEE W
Sbjct: 445 KIHEQ--EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVW---- 498
Query: 1579 RKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFA 1638
R E+K +E K+ ++EEK+ ++E ++ ++E K+ + KI + + M + E K
Sbjct: 499 ----RQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG 554
Query: 1639 QKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVE 1698
++EE + Q EK+ ++ EK+ ++ +K+ ++ EK+ +EEK+
Sbjct: 555 EQEEKM-QEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI------------------- 594
Query: 1699 ELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAW 1758
W+++E +E EE+ + EE W++EE K+ E+++K+ E+EE +
Sbjct: 595 ----------WEQEEKIREQEEMMQEQEEKMWEQEE------KMCEQEEKMQEQEEKMRR 638
Query: 1759 QREKLSEEETKLAQEEELLIQEKEKL 1784
Q EK+ E+E +L Q+EE + + +E L
Sbjct: 639 QEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 149 bits (375), Expect = 5e-35
Identities = 142/596 (23%), Positives = 286/596 (47%), Gaps = 80/596 (13%)
Query: 1792 PEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKE 1851
PE+E++ + ++ + ++++ R + + T+ +M LY ++ K L E
Sbjct: 107 PEDEQKASHQHQEALRRELEAQVHTIRILTCQK--TELQMALYYSQHAV---KQLEGEAR 161
Query: 1852 KLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQE--KETVIKK--KE 1907
L R + L + + K K + + L + + L+ E + T+ + KE
Sbjct: 162 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 221
Query: 1908 KLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELD-IAKEEKALNLE 1966
K A+ ++KL VE ++ Q + + K KL K ++ +++L+ E D + KE ++++ +
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP-QQQLQAEADHLGKELQSVSAK 280
Query: 1967 MKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAM 2026
++ EE E L++ + + RQ + Q +E + + EEKI E++I
Sbjct: 281 LQAQVEEN----ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ---EEKIREQEEKIREQ 333
Query: 2027 EESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRD 2086
EE K+ + + +K E K+ R
Sbjct: 334 EE----------------------KMRRQEEMMWEKEE-----------------KMRRQ 354
Query: 2087 ERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD----IKEWDFSEKRSELTKDEKKLARK 2142
E + ++E KM +++ ++ KE ++ + K+ I+E + + E ++++K +
Sbjct: 355 EEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 414
Query: 2143 QRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKE 2202
+ K+ + ++ +EEK+ E+E K+ R+ ++ E+ I EEE + WR+ ++
Sbjct: 415 EAKMWRQEEKIREQEEKIREQEKKMWRQEEKI----HEQEKIREEEKRQEQEEMWRQEEK 470
Query: 2203 AKRGD---KPKEKFSSQVDEVESEEHFSEEMESLLDELEK----QESLSSEEEEEREEEE 2255
+ + + KEK Q + EE + E + D+ EK +E + +EE+ RE+EE
Sbjct: 471 IREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEE 530
Query: 2256 E--REEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIM 2313
+ +EE++RE+EE +E+EE +Q EK +E++K +++E E+++E+EE E++E +
Sbjct: 531 KIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE---EKIREQEEKIREQKEKI 587
Query: 2314 SEEETESLSDEE---EEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERV 2366
E+E + EE E+EE +EE E+E E++ K+QEQ K R E++
Sbjct: 588 REQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 643
Score = 143 bits (360), Expect = 3e-33
Identities = 156/587 (26%), Positives = 292/587 (49%), Gaps = 90/587 (15%)
Query: 1712 KELAQELEELEWDMEELSWK-EEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKL 1770
K+L E +L + + SWK EL Q + +KKK E L +R+ LS E +
Sbjct: 154 KQLEGEARDLISRLHD-SWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 212
Query: 1771 AQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSME---ELT 1827
+E L KEK A+ +EK+ QL+E ++K E +N E +L
Sbjct: 213 TITDEEL---KEKNAKLQEKL------------QLVE-----SEKSEIQLNVKELKRKLE 252
Query: 1828 KNKMILYQKKNLAQEKKNLAQEKEKL-----AQRKENLLYNKERLTHSKKQLVQVKNKLG 1882
+ K++L Q++ L E +L +E + + AQ +EN L+N+ +K Q +
Sbjct: 253 RAKLLLPQQQ-LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK--- 308
Query: 1883 MFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLA-QEKMKLALEK 1941
+ + EEK+ +++E + +++EK+ E E+K+ + E+ + +K+EK+ QE+M E+
Sbjct: 309 -----IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363
Query: 1942 AMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQR---KM 1998
M +RL E+ KEEK LE K +EK+R E K + + RQ KM
Sbjct: 364 KM----RRLE-EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 418
Query: 1999 TQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRK 2058
+ E+++ E+ EEKI E ++ EE + K+ + Q Q ++ + K
Sbjct: 419 WRQEEKIREQ----EEKIREQEKKMWRQEEKIHEQEKIREEEKR----QEQEEMWRQEEK 470
Query: 2059 LIKKRESLSKEPAKLN---KILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQ 2115
I+++E + ++ K++ KI K +K+ R E K+ +E K+ + + ++ +E ++ ++
Sbjct: 471 -IREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQE 529
Query: 2116 SKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVI 2175
K+ +E E+ + + E+K+ ++ K+ + +M +EEK+ E+E K+ R+ E I
Sbjct: 530 EKIREQEEKIREQEEMMQEQEEKMGEQEEKM-QEQEKMRRQEEKIREQEEKI-REQKEKI 587
Query: 2176 LDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLD 2235
+ EE+ +EE++ R+++E + E EE E+ E +
Sbjct: 588 REQEEKIWEQEEKI--------REQEEMMQ---------------EQEEKMWEQEEKMC- 623
Query: 2236 ELEKQESLSSEEEEEREEEEEREEEEVR--EEEEERKEEEEGEEKQV 2280
E++E + +EE+ R +EE+ E+EVR ++EE+ +E +E E +
Sbjct: 624 --EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 139 bits (350), Expect = 4e-32
Identities = 150/641 (23%), Positives = 317/641 (49%), Gaps = 103/641 (16%)
Query: 1701 PQREQNLDWQEKE-LAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQ 1759
P+ EQ Q +E L +ELE + L+ ++ EL K+L E L +
Sbjct: 107 PEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 166
Query: 1760 REKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKR-------EQLIEKKMKL 1812
+ +L Q + +K+K ++ E++ +E + L + E+L EK KL
Sbjct: 167 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 226
Query: 1813 AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK 1872
+K + + E K+++ L N+ + K+ L + K L Q++ + H K
Sbjct: 227 QEKLQ-----LVESEKSEIQL----NVKELKRKLERAKLLLPQQQL-----QAEADHLGK 272
Query: 1873 QLVQVKNKLGMFNKILAQVEE-----KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQ 1927
+L V KL AQVEE +L Q++E EK+ E+K+ + E+ + +++
Sbjct: 273 ELQSVSAKLQ------AQVEENELWNRLNQQQE------EKMWRQEEKIQEWEEKIQEQE 320
Query: 1928 EKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKG 1987
EK+ +++ K+ ++ K R + E+ KEEK M+R +E+M + E +E + +
Sbjct: 321 EKIREQEEKIREQEE----KMRRQEEMMWEKEEK-----MRR--QEEM-MWEKEEKMRRL 368
Query: 1988 ETPETSRQRKMTQVEQELFER-KLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046
E ++ K+ ++E+++ E+ K+ +E+ E++I E+ + + K+ R +
Sbjct: 369 EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM--WRQEEKIR 426
Query: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFV 2106
+ + K+ + +K+ ++ E + ++ +K+ +E++ QEE+ + K
Sbjct: 427 EQEEKIREQEKKMWRQEEKIHEQ-----------EKIREEEKRQEQEEMWRQEEK----- 470
Query: 2107 KERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESK 2166
I+E + ++ E +++K+ +++ K+ + +M ++EEK+ E+E K
Sbjct: 471 -------------IREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEK 517
Query: 2167 LARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHF 2226
+ R+ ++ ++EE E+EE I R++ + + +EK Q ++++ +E
Sbjct: 518 MWRQEEKI--REQEEKIREQEEKI---------REQEEMMQEQEEKMGEQEEKMQEQEKM 566
Query: 2227 SEEMESLLDELEKQESLSSEEEEEREEEEE--REEEEVREEEEERKEEE----EGEEKQV 2280
+ E + E++E + ++E+ RE+EE+ +EE++RE+EE +E+E E EEK
Sbjct: 567 RRQEEKIR---EQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMC 623
Query: 2281 EKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESL 2321
E+EE+ +++++K +++EE ++EV ++E +E E L
Sbjct: 624 EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 138 bits (348), Expect = 7e-32
Identities = 102/453 (22%), Positives = 255/453 (56%), Gaps = 43/453 (9%)
Query: 1592 ERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKL 1651
+ +L ++ KL QE+ QL + E+ Q VK + E A K ++ L + L
Sbjct: 216 DEELKEKNAKL-QEKLQLVESEKSEIQLNVKELKRKLERA----KLLLPQQQLQAEADHL 270
Query: 1652 SQEAEKLAQKRKKLAKK---WEKV-AREEEKLAKKGGKLAEVKNILAQKVEELPQREQNL 1707
+E + ++ K + ++ W ++ ++EEK+ ++ K+ E + + ++ E++ ++E+ +
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 330
Query: 1708 DWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEE 1767
QE+++ ++ EE+ W+ EE ++EE+ E+ EEK + EE + W++E+
Sbjct: 331 REQEEKMRRQ-EEMMWEKEEKMRRQEEMMWEK----EEKMRRLEE---MMWEKEE----- 377
Query: 1768 TKLAQEEELL-----IQEKEKLAQHKEKMPEEEER------LGRKREQLIEKKMKLAQKR 1816
K+ + EE + I+E+E+ Q +EK+ E+E+R + R+ E++ E++ K+ ++
Sbjct: 378 -KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 436
Query: 1817 ERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQ 1876
++ E++ + + I ++K QE++ + +++EK+ +++E ++ ++ H ++++ +
Sbjct: 437 KKMWRQEEKIHEQEKIREEEKR--QEQEEMWRQEEKIREQEE--IWRQKEKMHEQEKIRK 492
Query: 1877 VKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMK 1936
+ K+ + + EEK+ +++E + +++EK+ E E+K+ + E+ + +++E + +++ K
Sbjct: 493 QEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEK 552
Query: 1937 LA-LEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQ 1995
+ E+ M + +K R E I ++E+ + + +++ E++ ++ E +E + + E ++
Sbjct: 553 MGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQE 612
Query: 1996 RKMTQVEQELFERKLSLEEKILLHEDRILAMEE 2028
KM + E+++ E+ EEK+ E+++ EE
Sbjct: 613 EKMWEQEEKMCEQ----EEKMQEQEEKMRRQEE 641
Score = 136 bits (342), Expect = 3e-31
Identities = 96/405 (23%), Positives = 221/405 (54%), Gaps = 46/405 (11%)
Query: 1313 EKKPIFIQEGAIRE--DMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKG 1370
+++ ++ QE I+E + IQ +E IR +E RE+E+ ++ +M+ +E ++
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQE-QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM----- 351
Query: 1371 KKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAV---QKERKVGKIKREMTKEERDM 1427
+++E+ ++K K R +KE K+ +++ +M ++E+
Sbjct: 352 ------------------RRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEK-- 391
Query: 1428 SEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEK 1487
E EE EEK+ +QE + + W+ +K ++ +++ + +K W+ ++ E+
Sbjct: 392 IREQEEKRQEEEKIREQEKR--QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 449
Query: 1488 RLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLE 1547
++EEEK Q E++ +EE ++E +++ W + +++ E K +E+ ++ EE++ +
Sbjct: 450 EKIREEEK-RQEQEEMWRQEEKIREQEEI-WRQKEKMHEQEKIRKQEEKVWRQEEKMHDQ 507
Query: 1548 EEVSREGEEK----EQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLA 1603
EE RE EEK E+++ E++ I+E+ + R E+ ++E K+ ++EEK+
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIR------EQEEMMQEQEEKMGEQEEKMQ 561
Query: 1604 QEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRK 1663
++E+ QEE K+ + KI + ++ + E K ++EE + ++ E + ++ EK+ ++ +
Sbjct: 562 EQEKMRRQEE-KIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE 620
Query: 1664 KLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLD 1708
K+ ++ EK+ +EEK+ ++ K+ E + L Q+ E++ + +++L+
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 136 bits (342), Expect = 3e-31
Identities = 91/354 (25%), Positives = 203/354 (57%), Gaps = 18/354 (5%)
Query: 1385 KEISKKEEK--KTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVV 1442
++I ++EEK + +K +Q K ++E + + + +M ++E M E+ E+M LEE +
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMW 373
Query: 1443 KQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEE---W--EKRLLQEEEKLH 1497
++E K+ +E Q+ + +E +Q + R+ K ++E W E+++ ++EEK+
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 1498 QAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD---EEEVTLEEEVSREG 1554
+ +K+ +EE + E +K++ EE +Q E M + K ++ ++ ++E E+E R+
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ 493
Query: 1555 EEK----EQQVTEEQRHI--QEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQ 1608
EEK E+++ +++ I QEE W + + R + EK R QEE+ +E+E++ QE+ +
Sbjct: 494 EEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEK--IREQEEMMQEQEE 551
Query: 1609 LAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKK 1668
E+ + Q K+ + + ++ + E K +++E + ++ EK+ ++ EK+ ++ + + ++
Sbjct: 552 KMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQ 611
Query: 1669 WEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELE 1722
EK+ +EEK+ ++ K+ E + + ++ E++ ++E L QE+++ + E LE
Sbjct: 612 EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 115 bits (287), Expect = 8e-25
Identities = 121/554 (21%), Positives = 259/554 (46%), Gaps = 84/554 (15%)
Query: 1090 KKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKL 1149
KK + +++ L TKERD+ + + DE E++E + KL
Sbjct: 188 KKKADRYIEEL--TKERDALSLELYRNTITDE--------ELKEKNA-----------KL 226
Query: 1150 SKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPP 1209
+ + E + K I L +K L++ ++ Q+L+ + GKE + ++ +
Sbjct: 227 QEKLQLVESE--KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284
Query: 1210 VMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAEL 1269
V E + ++ Q + W + + + +I + K+ E E
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKI-----QEWEEKI-QEQEEKIREQEEKIREQ--EEK 336
Query: 1270 VTFAQEMLVDRHPSWELFQEICPLLKKESKVL-LEDLDWDVVPPEKKPIFIQEGAIREDM 1328
+ +EM+ ++ +E+ + +KE K+ LE++ W+ E+K ++E ++
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEM--MWEKEEKMRRLEEMMWE---KEEKIRELEEKMHEQEK 391
Query: 1329 IQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEIS 1388
I+ QE R +E RE+E+ Q++ M EE I ++ +K+
Sbjct: 392 IR--EQEEKRQEEEKIREQEKRQEQEAKMWRQEEK--IREQEEKI--------------- 432
Query: 1389 KKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVE-----EMATLEEKVVK 1443
+++EKK +++ K + +E + + + EM ++E + E+ E E +EK+ K
Sbjct: 433 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRK 492
Query: 1444 QEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKL 1503
QE K+ W+ +K D+ +++ + K W+ E+++ ++EEK+ + EK+
Sbjct: 493 QEEKV--------WRQEEKMHDQEEKIREQEEKMWRQ-----EEKIREQEEKIREQEEKI 539
Query: 1504 SPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEK----EQ 1559
+EEM+QE ++ E+ +++ E + +E+ + EE++ ++E RE EEK E+
Sbjct: 540 REQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEE 599
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQA 1619
++ E++ +QE+ + K E+K ++E K+ ++EEK+ ++E ++ ++E +L Q
Sbjct: 600 KIREQEEMMQEQEE------KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 653
Query: 1620 YVKITQDDREMAQA 1633
K+ + + A
Sbjct: 654 EEKMQEHQEHLEAA 667
Score = 52.8 bits (125), Expect = 5e-06
Identities = 54/252 (21%), Positives = 123/252 (48%), Gaps = 34/252 (13%)
Query: 2202 EAKRGDKPKEKFSSQVDEVESE--------EHFSEEMESLLDELEKQESLSSEEE---EE 2250
+ K+ D+ E+ + + D + E E E+ L ++L+ ES SE + +E
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 246
Query: 2251 REEEEEREEEEVREEEEERKEEEEGEE---------KQVEKEE-----EEKKKKKKEKKK 2296
+ + ER + + +++ + + + G+E QVE+ E +++++K +++
Sbjct: 247 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE 306
Query: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEE----EEEESCSLEEEVDREKEIL--KKEKQF 2350
E++QE EE +E+EE + E+E + EE +EE EE++ R++E++ K+EK
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 2351 KLQE---QRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVP 2407
+L+E ++ + +R E + + + + ++ K+ A +++ +
Sbjct: 367 RLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 426
Query: 2408 VPEKQISWEDKK 2419
E++I ++KK
Sbjct: 427 EQEEKIREQEKK 438
Score = 38.1 bits (87), Expect = 0.13
Identities = 53/255 (20%), Positives = 124/255 (48%), Gaps = 25/255 (9%)
Query: 2134 KDEKKLARK-QRKLANKMRRMINKEEKMT--EEESKLARKHSEVILDDEEEGGIEEEEVI 2190
+DE+K + + Q L ++ ++ +T + E ++A +S+ + E E ++I
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEG---EARDLI 164
Query: 2191 PFLKRRWRKRKEAKRG----DKPKEKFSSQVDEVESE-EHFSEEM--ESLLDELEKQESL 2243
L W+ E ++ K+K ++E+ E + S E+ ++ DE E +E
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE-ELKEKN 223
Query: 2244 SSEEEEEREEEEEREEEEVREEEEERKEEEEG---EEKQVEKEEEEKKKKKKE---KKKE 2297
+ +E+ + E E+ E ++ +E +RK E ++Q++ E + K+ + K +
Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 283
Query: 2298 EVQEKE---EVFEEKEEIM--SEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKL 2352
+V+E E + +++EE M EE+ + ++ +E+E E+E ++ K +Q ++
Sbjct: 284 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343
Query: 2353 QEQRRKSLRGRERVL 2367
++ + +R +E ++
Sbjct: 344 MWEKEEKMRRQEEMM 358
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 176 bits (447), Expect = 2e-43
Identities = 313/1451 (21%), Positives = 626/1451 (43%), Gaps = 172/1451 (11%)
Query: 992 LTQKQETFREMQQQMIGE-EPLDHL-------LGMRATDLQILSTQVEQRLNENLTLSHR 1043
LT ++E +E + + E E + L L + D + L Q+EQ + + R
Sbjct: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR 371
Query: 1044 DEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKH---SQKWLRGL 1100
+ ++L+S +K T E E+ + K +R ++K +QK
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGE-ELREQKEKSERAAFEELEKALSTAQKTEEAR 430
Query: 1101 KKTKERDSKQMSTEPGLLEDESGT---EAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQE 1157
+K K +Q+ T E+E + E + ++ E V + SS + KL K E
Sbjct: 431 RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKK-SSEEQIAKLQK---LHE 486
Query: 1158 KDISKDHIALTLKRLQKIRDKRDK------KATAQKLKKKHKKKGKEAKVINE-ETTPPV 1210
K++++ LT K + R+ +++ K+ ++ LK +K+ +E+ + E E
Sbjct: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
Query: 1211 MEQPVTKKVKIQGRGASGISGR----RSTAGDGSSWRDDLCRLMALRISGSQTKMSENLN 1266
+ K++ + A R S+ + + +A+ + + K ++ +
Sbjct: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
Query: 1267 AELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIRE 1326
+ E+ +H L+ E +LK++ + +E L + EK+ + + I +
Sbjct: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR-EKCEQEKETLLKDKEIIFQ 665
Query: 1327 DMIQGVTQEVIRHKEVMPREEEQAQKKARDMLG----LEETQVILKKGKKVIFLEPGNVT 1382
I+ + ++ + +V E E + ++L LEE +LK + +
Sbjct: 666 AHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD-------QTDKMK 718
Query: 1383 MGKEISKKEEKKTFQKSP----KQGRKAVQKERKVGKIK---REMTKEERD--MSEEVEE 1433
E E+K Q+ K+ ++Q+ K K + E+ +ERD + E
Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAH 778
Query: 1434 MATLEEKVVKQEGKLVMIE-RTPSWQDWKKAWDEWKQVHGE--TRKSWKAWKEEWEKRLL 1490
+ LE + + EG+L + +Q ++ A E + + E + K E E+ LL
Sbjct: 779 VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILL 838
Query: 1491 QEEEKLHQA----------GEKLSPEEEMLQEDKKLKWEEWK-----QVWENMLSSKSKE 1535
++ +A K+ ++ M Q +K+ E K QV+E+ L +KE
Sbjct: 839 TKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE 898
Query: 1536 QQYKDEEEVTLEEEV--SREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEER 1593
Q+ + V E + REG++KE ++ ++ +E+ IH E K +E+
Sbjct: 899 QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS----IHILNEEYETKFKNQEK 954
Query: 1594 KLAQEEEKLAQEE----RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE 1649
K+ + ++K + + ++L +E KL + ++ E++Q E +F K +AQ
Sbjct: 955 KMEKVKQKAKEMQETLKKKLLDQEAKLKK---ELENTALELSQKEKQFNAKMLEMAQANS 1011
Query: 1650 K-LSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNI----LAQKVEELPQRE 1704
+S +L +K+ + +V R E L +V +I L Q+ EEL Q
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRE---------LNDVISIWEKKLNQQAEEL-QEI 1061
Query: 1705 QNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLS 1764
+ QEKE QE+ EL+ + ++EE+N+E L EE K L Q ++ S
Sbjct: 1062 HEIQLQEKE--QEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS 1119
Query: 1765 EEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSME 1824
LAQ+E L EKL K +E L +EQL+E KM LA++ +R ++ +
Sbjct: 1120 AHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL---QEQLVELKM-LAEEDKRKVSELT 1175
Query: 1825 ELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRK--ENLLYNKERLTHSKKQLVQVK-NKL 1881
K +Q + EK N + E + L +K E L + + L++ K N+L
Sbjct: 1176 SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL 1235
Query: 1882 -----GMFNKILAQV---EEKLTQEKETVIKKKEKLAETEKKLVQV-----------EDS 1922
N IL+++ + + T+ KE ++ K ++E E +L Q+ + +
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 1923 LAKKQEKLAQEKMKLALEKAMVQGKKRLRGE----LDIAKEEKALNLEMKRLAEEKMRLV 1978
+ +EK Q K A +++V K+ L+ E A E+++ ++K+ E + V
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAV 1355
Query: 1979 E-GKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLE 2037
KE L + + +S +++T + +L + +SL EK + ++ + + K E
Sbjct: 1356 TLMKEELKEKKVEISSLSKQLTDLNVQL-QNSISLSEK-----EAAISSLRKQYDEEKCE 1409
Query: 2038 FTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKM 2097
+ L+K +++ + S + ++ K KA + T+ + + + +I++
Sbjct: 1410 LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK--KAQSRFTQHQNTVKELQIQL 1467
Query: 2098 TKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMR----RM 2153
+ + K+ ++++ + +LD + F + E+ D+ K+ +K+ L +++ R+
Sbjct: 1468 ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARI 1527
Query: 2154 INKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKF 2213
+ E+ +T++ ++ +EV+ + ++ IE +E++ +K
Sbjct: 1528 MELEDHITQKTIEI-ESLNEVLKNYNQQKDIEHKELV--------------------QKL 1566
Query: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273
+ E +++ +E E + LE Q E E +++E E V+ +EEE K E
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 2274 EGEEKQVEKEEEEKKKKKKEK----KKE---EVQEKEEVFEEKEEIMSEEETESLSDEEE 2326
+ E + + E K+K ++K KK+ +++EKEE +++ E E L +E
Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL--QER 1684
Query: 2327 EEESCSLEEEV 2337
E E LEE++
Sbjct: 1685 EREVHILEEKL 1695
Score = 139 bits (351), Expect = 3e-32
Identities = 302/1605 (18%), Positives = 650/1605 (40%), Gaps = 266/1605 (16%)
Query: 985 SRTSLLQLTQKQETFREMQQQMIGEEPLD----HLLGMRATDLQILSTQVEQRLNENLTL 1040
S++ L+++Q++E QQ+ + E L+ +L L+ L + E L L
Sbjct: 518 SQSEYLKISQEKE-----QQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILEL 572
Query: 1041 SHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGL 1100
EK + + + +L L+ E+ + K + ++ + W L
Sbjct: 573 ESSLEK-SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKL 631
Query: 1101 KKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDI 1160
+ K+ Q TE L ++ E + ++ ++ + L K +D ++ ++
Sbjct: 632 QVLKQ----QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEK-LDVKQTEL 686
Query: 1161 SKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVK 1220
+ ++ L + K R K +++ + K + K+ EAK+ ++ + K+ +
Sbjct: 687 --ESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE 744
Query: 1221 IQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEMLVDR 1280
+ I D + + L + + Q + ENL A++ E L
Sbjct: 745 VS------IQRTEKALKDQINQLELLLKERDKHLKEHQAHV-ENLEADIKRSEGE-LQQA 796
Query: 1281 HPSWELFQEICPLLKKESKVL---LEDLDWDVVPPEKKPIFI-QEGAIREDMIQGVTQEV 1336
++FQ +++K L L ++ E + I + ++ A E + V E+
Sbjct: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
Query: 1337 IRHK-------EVMPREEEQAQKKARDMLGLEETQVI-----LKKGKKVIFLEPGNVTMG 1384
HK + + ++ + ++K + + + E+++ ++ K+++ + +
Sbjct: 857 DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQM 916
Query: 1385 KEISKKEEKKTFQK-SPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVK 1443
+E KKE + QK S K+ + E K K + K E+ + E TL++K++
Sbjct: 917 REGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLD 976
Query: 1444 QEGKL------VMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQE----- 1492
QE KL +E + + + E Q + + E +K ++
Sbjct: 977 QEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVH 1036
Query: 1493 -----------EEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD- 1540
E+KL+Q E+L E+ ++K+ + E KQ + +L KE+ K+
Sbjct: 1037 RRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQ--KILLFGCEKEEMNKEI 1094
Query: 1541 ---EEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQ 1597
+EE ++ E +E+ +Q + + ++ + H ++ + ++ +E Q
Sbjct: 1095 TWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQ 1154
Query: 1598 EEEKLAQEERQLAQEE-RKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAE 1656
E+ E + LA+E+ RK+++ K+ D E + + ++L + + + +E
Sbjct: 1155 EQ---LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
Query: 1657 KLAQKRKKLAKKWE------------------------------KVAREEEKLAKKGGKL 1686
+LA + KK E + + +E L K +
Sbjct: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
Query: 1687 AEVKNILAQKVEELPQREQNLDWQE-----KELAQELEELEWDMEELSWKEEELNQEEGK 1741
+E++ L Q EE Q N+ +Q+ +E +++ ++ D+E L ++E L +E G
Sbjct: 1272 SELEAQLRQLTEE--QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGN 1329
Query: 1742 -----------LVEEKKKLAEEEEALAWQREKLSEEETKLAQ------------EEELLI 1778
+ + KK+L+E A+ +E+L E++ +++ + + +
Sbjct: 1330 QQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL 1389
Query: 1779 QEKEKLAQHKEKMPEEE--------ERLGRKREQLIEKKMKLAQKRERWIN--------- 1821
EKE K +EE + L K + L ++K+ ++ + W N
Sbjct: 1390 SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
Query: 1822 ---------------------SMEELTKNKMILYQKKNLAQEKKN-------LAQEKEKL 1853
S E K++ I K+ L Q+ K + +K K+
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
Query: 1854 AQRKENLLYNKE----RLTHSKKQLVQVKNKLGMFNKILAQV-EEKLTQEKETVIK---- 1904
+++ NL + R+ + + Q ++ N++L ++K + KE V K
Sbjct: 1510 EKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHF 1569
Query: 1905 ------KKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKR-LRGELDIA 1957
K ++ E E+K++ +E+ + + +L +K +L V+ K+ L+ D
Sbjct: 1570 QELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRL 1629
Query: 1958 KEEKALNL-EMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKI 2016
+ E A L E+KR AE+K+ ++ K+ LS+ E E ++ EL + E ++
Sbjct: 1630 ESESAAKLAELKRKAEQKIAAIK-KQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREV 1688
Query: 2017 LLHEDRILAMEESEI--------AKGKLEFTRGQRIFVQG------QRKLAKASRKLIKK 2062
+ E+++ ++E S+ AK +T + QG + K++ R L +K
Sbjct: 1689 HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEK 1748
Query: 2063 RESLSKEPAKLNKILKA-----------LQKLTRDERKLTQEEIKMTKMKRALFVKERRL 2111
+ L + + + + + L KL E K +++ + ++ L K ++
Sbjct: 1749 EKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKY 1808
Query: 2112 SI--------EQSKLDIK-----EWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEE 2158
S+ E K +I+ E F + + L + E ++K+ ++ ++E
Sbjct: 1809 SLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKE 1868
Query: 2159 KMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVD 2218
E +L K+ ++ + +G + E++ +E + + K S ++
Sbjct: 1869 VHRVEMEELTSKYEKLQALQQMDGRNKPTELLE------ENTEEKSKSHLVQPKLLSNME 1922
Query: 2219 EVESEEHFS-----EEMESLLDELEK-QESLSSEEEEEREEEEEREEEEVREEEEERKEE 2272
++ F E + L E+ + Q+ L +E ++E E ++E +E EE+ K+E
Sbjct: 1923 AQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQE 1982
Query: 2273 EEGEE-------KQVEKEEEEKKKKKKEKK----KEEVQEKEEVFEEKEEIMSEEETESL 2321
+E E KQ+ +E + +K+++ KE + + +EV E E EE + L
Sbjct: 1983 QEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLL 2042
Query: 2322 -----SDEEEEEESCSLEEEVD-REKEILKK--EKQFKLQEQRRK 2358
D++ + + EE +D RE+E+ K + Q +L+E ++K
Sbjct: 2043 KKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK 2087
Score = 125 bits (315), Expect = 5e-28
Identities = 206/980 (21%), Positives = 421/980 (42%), Gaps = 128/980 (13%)
Query: 1482 KEEWEKRLLQEEEKLHQAGEKLSP---EEEMLQEDKKLKWEEWKQVWENML---SSKSKE 1535
KE+ +RL + E L K S +MLQ +KK Q + L + +E
Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195
Query: 1536 QQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKL 1595
Q + + L+EE EEK+Q ++ Q + + ++R R + L
Sbjct: 196 LQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVS-------LLKQRLRNGPMNVDVLKPL 248
Query: 1596 AQEE---EKLAQEERQLAQEERKLAQAYVKITQD--DREMAQAEGKFAQKEETLAQRGEK 1650
Q E E +EE + E + T + + + + E + +ET+ E+
Sbjct: 249 PQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQ 308
Query: 1651 ---LSQEAEKLAQKRKKLAKKWEKV----AREEEKLAKKGGKLAEVKNILAQK------- 1696
L+ E E L ++ + ++ EK+ E+ KL +L + KN++ Q
Sbjct: 309 CTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLIT---QLRDAKNLIEQLEQDKGMV 365
Query: 1697 -VEELPQREQNLDWQEKELAQ-------------ELEELEWDMEELSWKE-EELNQEEGK 1741
E Q + L+ +E+E+AQ EL E + E +++E E+ K
Sbjct: 366 IAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK 425
Query: 1742 LVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEE------- 1794
E ++KL E + EK SEEE Q+E L + K+++ +K EE
Sbjct: 426 TEEARRKLKAEMDEQIKTIEKTSEEERISLQQE--LSRVKQEVVDVMKKSSEEQIAKLQK 483
Query: 1795 --EERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEK 1852
E+ L RK ++L +K Q RER E + + +K K + +E+++
Sbjct: 484 LHEKELARKEQELTKK----LQTRER------EFQEQMKVALEKSQSEYLKISQEKEQQE 533
Query: 1853 LAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAET 1912
+E L K LT S+ +L ++ + + + ++E L + + + + LA
Sbjct: 534 SLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVH 593
Query: 1913 EKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLE--MKRL 1970
++ E + K+ + EK K LE Q +L + K++ +E ++
Sbjct: 594 ----LEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
Query: 1971 AEEKMRLVEGKETLSKGETPETSRQR------KMTQVEQELFERKLSLEEKILLHEDRIL 2024
+EK L++ KE + + E + + K T++E E L+ + L E+ +
Sbjct: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSV 709
Query: 2025 AMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRE-SLSKEPAKLNKILKALQKL 2083
++++ K +LE ++ + + +IK+ E S+ + L + L+ L
Sbjct: 710 LKDQTDKMKQELEAKMDEQ-----KNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELL 764
Query: 2084 TRD-ERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARK 2142
++ ++ L + + + ++ + E L +KLD+ + S + E++LA+
Sbjct: 765 LKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL 824
Query: 2143 QRKLANKMRRMINKEEKMTEEESKLARKHSEV---------ILDDEEEGGIEEEEVIPFL 2193
Q+KL + I +++ E E++ +E+ ++ E+ E E+ + L
Sbjct: 825 QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 2194 KRRWRKRKEAKRGDKPKEKFSSQVDEVES-----EEHFSEEMESLLDELEKQESLSSEEE 2248
+ + + E G+K +E+ + E E+ E +E+E L +L +E
Sbjct: 885 TQVYESKLE--DGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN 942
Query: 2249 EEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEE 2308
EE E + + +E+++ + +++ KE +E +K++ ++E K KK+ E E+ +KE+ F
Sbjct: 943 EEYETKFKNQEKKMEKVKQKAKEMQETLKKKL-LDQEAKLKKELENTALELSQKEKQFNA 1001
Query: 2309 KEEIMSEEETESLSD--------EEEEEESCS-------------LEEEVDREKEILKKE 2347
K M++ + +SD ++E+ ES + E++++++ E L++
Sbjct: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
Query: 2348 KQFKLQEQRRKSLRGRERVL 2367
+ +LQE+ ++ ++++L
Sbjct: 1062 HEIQLQEKEQEVAELKQKIL 1081
Score = 82.0 bits (201), Expect = 8e-15
Identities = 194/977 (19%), Positives = 410/977 (41%), Gaps = 145/977 (14%)
Query: 1858 ENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLV 1917
E+L+ N + L +K+QL+Q +L + L+ K ++ + ++ + EKK +
Sbjct: 125 EDLVGNSDSL--NKEQLIQ---RLRRMERSLSSYRGKYSE-----LVTAYQMLQREKKKL 174
Query: 1918 Q--VEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKA--LNLEMKRLAEE 1973
Q + S K ++A+ + +L +++ Q KK L+ E D + EEK +++ +++
Sbjct: 175 QGILSQSQDKSLRRIAELREELQMDQ---QAKKHLQEEFDASLEEKDQYISVLQTQVSLL 231
Query: 1974 KMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAK 2033
K RL G + + + Q+E + + EE+ +
Sbjct: 232 KQRLRNGPMNVDV--------LKPLPQLEPQA----------------EVFTKEENPESD 267
Query: 2034 GKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQE 2093
G+ G + K + ++ +K++E+L K + + K L E++ QE
Sbjct: 268 GEPVVEDGTSV------KTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQE 321
Query: 2094 EIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELT--KDEKKLARKQRK-----L 2146
++ ER +E+ IK+ +EK +T +D K L + + +
Sbjct: 322 QLD-----------ERLQELEK----IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVI 366
Query: 2147 ANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRG 2206
A R+M E EE ++L + ++ EE R +++ E
Sbjct: 367 AETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE-------------LREQKEKSERAAF 413
Query: 2207 DKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEER-EEEEEREEEEV--- 2262
++ ++ S+ E+ EM+ + +EK +SEEE ++E R ++EV
Sbjct: 414 EELEKALSTAQKTEEARRKLKAEMDEQIKTIEK----TSEEERISLQQELSRVKQEVVDV 469
Query: 2263 --REEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETES 2320
+ EE+ + ++ EK++ ++E+E KK + +++ E QE+ +V EK S+ E
Sbjct: 470 MKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER-EFQEQMKVALEK----SQSEYLK 524
Query: 2321 LSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVL--------SILRG 2372
+S E+E++ES +L EE++ +K+ + E + KL++ ++++ R R+L S+
Sbjct: 525 ISQEKEQQESLAL-EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQEN 583
Query: 2373 VPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQ--ISWEDKKATVVEIPRKFL 2430
K A+ L K+ K ++ +E K KT + + Q W +K + + +++
Sbjct: 584 KNQSKDLAVHLEAEKNKHNKEITVMVE-KHKTELESLKHQQDALWTEK---LQVLKQQYQ 639
Query: 2431 GTMDKEREVMGKYEPIPPHVLGTVLESQAQDLKTPFMSHILRRTVEAEELQ---HKPLGA 2487
M+K RE + + + ++ +++ + + + E E L + L A
Sbjct: 640 TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699
Query: 2488 WWKWFLQHPPLMGQTEVQLPLSQIPAKEQHADVSLSDVEWIRHVLERMEAGEQLSRDGFH 2547
K + L QT+ + EQ I+ ++ E+ +D +
Sbjct: 700 RHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQIN 759
Query: 2548 RLCQLLKDLASKGNLEWLHLAKHEAIVYRHRQALESQDTRISSRQSMSPKYLKVIPPIKA 2607
+L LLK+ H+ EA + R L+ ++ QS + +
Sbjct: 760 QLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
Query: 2608 KEKESWPKPLAVPTQKSPLATKRIPDPRAKNWHLLGE-----PYRSERAQQISIAHKEME 2662
+ + K L + T++ L TK++ + A+ + E + QQ+ + EME
Sbjct: 820 QLAQLQQKLLDLETERI-LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
Query: 2663 MQYFYPATRDIFPSAHASVEK---QTLALMFQKDFWDFKDKRRFPKLPKLEKKTQPISKK 2719
+ + ++ S K QT ++ +K+ + + R + ++E TQ +S K
Sbjct: 879 QK--VKSLTQVYESKLEDGNKEQEQTKQILVEKE--NMILQMREGQKKEIEILTQKLSAK 934
Query: 2720 KEELPLWETFVALYHVLRMLQQRYPKDSTAWMEQFYQLMDLYQLKSPRIQKLLQELLMRE 2779
++ + H+L + K+ ME+ Q K+ +Q+ L++ L+ +
Sbjct: 935 EDSI----------HILNEEYETKFKNQEKKMEKVKQ-------KAKEMQETLKKKLLDQ 977
Query: 2780 EPQPQEIIYEEALKATE 2796
E + ++ + AL+ ++
Sbjct: 978 EAKLKKELENTALELSQ 994
Score = 70.9 bits (172), Expect = 2e-11
Identities = 164/852 (19%), Positives = 359/852 (42%), Gaps = 93/852 (10%)
Query: 966 KDERVRIKTLSL-MAEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQ 1024
K+++V I +LS + ++ + + S+ L++K+ +++Q EE + L +Q
Sbjct: 1363 KEKKVEISSLSKQLTDLNVQLQNSI-SLSEKEAAISSLRKQY-DEEKCELL-----DQVQ 1415
Query: 1025 ILSTQVEQRLNENLT-LSHRDEKPAFSLDVSMPSELKSSLKPPTVSE-ESEVAIKPSKGQ 1082
LS +V+ E ++ L D+ + ++ + + TV E + ++ +K +
Sbjct: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
Query: 1083 RRG-QAGVKKHS----QKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVY 1137
+ Q + K K LK E D +M + LE E ++ A I E +
Sbjct: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
Query: 1138 SQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGK 1197
+ S+ ++ K+ + Q+KDI + L+ Q++ +++D + K
Sbjct: 1536 QKTIEIESLNEVLKNYN-QQKDIEHKELVQKLQHFQELGEEKDNRV-----------KEA 1583
Query: 1198 EAKVINEETTPPVMEQPV-TKKVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISG 1256
E K++ E M+ + TKK +++ S +S + + D L A +++
Sbjct: 1584 EEKILTLENQVYSMKAELETKKKELEHVNLSV----KSKEEELKALEDRLESESAAKLAE 1639
Query: 1257 SQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKP 1316
+ K + + A +++L E + KK ++ L +L+ + E++
Sbjct: 1640 LKRKAEQKIAA----IKKQLLSQMEEKEEQY-------KKGTESHLSELNTKLQEREREV 1688
Query: 1317 IFIQEGAIREDMIQGVTQEVIRHKEVMPR--EEEQAQKKARDMLGLEETQVILKKGKKVI 1374
++E + Q T V R + + E+E+A + EE +L++
Sbjct: 1689 HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR----- 1743
Query: 1375 FLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEM 1434
N+T +++ ++ ++ + Q + ++ K++ K+ D S
Sbjct: 1744 -----NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ 1798
Query: 1435 ATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQE-- 1492
LEEK K + ++ +A + V + +K+ + EK L +
Sbjct: 1799 EELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ------EKELTCQIL 1852
Query: 1493 EEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEE--EVTLEEEV 1550
E+K+ + L ++E+ +++ EE +E + + + + + K E E EE+
Sbjct: 1853 EQKIKELDSCLVRQKEV----HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKS 1908
Query: 1551 SREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLA 1610
+ + E +H E K A R++ + K+ + ++ L ++ QE L
Sbjct: 1909 KSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILK 1968
Query: 1611 QEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWE 1670
+E + + +K Q+D E+ + ++ + + +L+Q+ ++L K+ K +
Sbjct: 1969 KEYDQEREEKIKQEQEDLELKHN----STLKQLMREFNTQLAQKEQELEMTIKETINKAQ 2024
Query: 1671 KVAREEEKLAKKGGKLAEVKNILAQKVEELPQR----EQNLDWQEKELAQELEELEWDME 1726
+V E E L + ++ +A+K ++L + E+ LD +E+E+ ++ +L+ +E
Sbjct: 2025 EV--EAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLE 2082
Query: 1727 ELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQ 1786
EL K ++ KL E+EE + E +T+LAQ+ L+ K K +
Sbjct: 2083 ELQKKYQQ------KL--------EQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
Query: 1787 HKEKMPEEEERL 1798
+E++ E+RL
Sbjct: 2129 FREQIHNLEDRL 2140
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 174 bits (442), Expect = 9e-43
Identities = 234/1047 (22%), Positives = 463/1047 (44%), Gaps = 127/1047 (12%)
Query: 1483 EEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD-- 1540
+E +++ E ++L Q +L+ E+ +LQE + + E + + E + +K+Q+ ++
Sbjct: 865 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 924
Query: 1541 -EEEVTLEEEVSR------EGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEER 1593
E E LEEE R E ++ QQ+ + + ++EE R++ + EK A+ +
Sbjct: 925 HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKI 980
Query: 1594 KLAQEEEKLAQEERQLAQEERKLAQAYVKITQ----DDREMAQAEGKFAQKEETLAQRGE 1649
K ++E + ++ +ERKL + + ++ E A+ K K E++ E
Sbjct: 981 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Query: 1650 KLSQEAEKLAQKRKKLAKKWEKVARE-EEKLAKKGGKLAEVKNILAQKVEELPQREQNLD 1708
++ EK Q+ +KL +K E A + E++A ++AE+K LA+K EEL LD
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 1709 ---WQEKELAQELEELEWDMEELSWKEEELNQE---EGKLVEEKKKLAEEEEALAWQREK 1762
Q+ +++ ELE + +L +E+L+ E K ++K+ L EE EAL + +
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDL---QEDLDSERAARNKAEKQKRDLGEELEAL---KTE 1154
Query: 1763 LSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINS 1822
L + A ++EL + ++++ K+ + EE Q+ E + K AQ E
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETR---SHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 1823 MEELTKNKMIL-YQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL 1881
+E+ + K L K+ L +E +LA E L Q K+ + + K++L + Q+ ++++K
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQSKC 1268
Query: 1882 GMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE- 1940
+ A++ +K+ + + V L E E K +++ +A +L Q+ +L E
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQELLQEE 1327
Query: 1941 ---KAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRK 1997
K V K R + +E +L ++ E K L TL+ + + +
Sbjct: 1328 TRQKLNVSTKLR-----QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 1998 MTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQR--------IFVQGQ 2049
+ L E K +++I E+ EE A KLE T+ + + + Q
Sbjct: 1383 FASTVEALEEGKKRFQKEI---ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 2050 RKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRAL---FV 2106
R+L K +K + L E ++ K + R E + ++E K + RAL
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISS--KYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 2107 KERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESK 2166
+ L L + D + ++ K+ +L + +R L +M M + E++ +E
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE--- 1554
Query: 2167 LARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK--RGDKPKEKFSSQVDEVESE- 2223
L E+ + E + LK ++ + +A+ + ++ + + Q+ E E+E
Sbjct: 1555 ---------LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 2224 ----------EHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273
+++E L +LE Q + + EE ++ + + ++++ + E ++
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 2274 EG-EEKQVEKEEEEKKKKKKEKKKEEVQE--------KEEVFEEKEEIMSEEETESLS-- 2322
+E +E EKK K E ++QE +++ EKEE ++EE SLS
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE-LAEELASSLSGR 1724
Query: 2323 -----------------DEEEEEESCSLEEEVDREKEILKKEKQF-------KLQEQRRK 2358
+EE EEE ++E DR ++ ++ +Q + Q+ +
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 2359 SLRGR-ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWED 2417
S R + ER LR H A++ KS + L + +++E+ EKQ + +
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVK-SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 2418 KKATVVEIPRKFLGTMDKEREVMGKYE 2444
K ++ ++ L ++ ER++ +Y+
Sbjct: 1844 LKQKDKKL-KEILLQVEDERKMAEQYK 1869
Score = 164 bits (414), Expect = 2e-39
Identities = 248/1129 (21%), Positives = 488/1129 (43%), Gaps = 144/1129 (12%)
Query: 1345 REEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKE---EKKTFQKSPK 1401
R+EE+ Q K ++ +E Q + K + + +T K + +++ E + + ++ +
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 1402 QGRKAVQKERKVGKIKREMT---KEERDMSEEVE--------EMATLEEKVVKQEG--KL 1448
+ K++++ +I EM +EE D ++++ +M LEE++ ++E +
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 1449 VMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEK------RLLQEEEKLHQAGEK 1502
+ +E+ + KK DE + + K K K E+ L +EEEK +
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028
Query: 1503 LSPEEEMLQE-DKKLKWEEWKQVWENMLSSKS---------------------KEQQYKD 1540
+ E M+ E + +LK EE + L K K Q K
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1088
Query: 1541 EEEVT-----LEEEVSREGEEKEQQVTEEQRHI---QEEHKWARIHRKRARAEKKRAQEE 1592
EEE+ L++E++++ ++ + E + HI QE+ R R +A +K+ EE
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147
Query: 1593 RKLAQEEEKLAQEERQLAQEERKLAQAYVKITQD--DREMAQAEGKFAQKEETLAQRGEK 1650
+ + E + + QE R + V + + D E E + + + AQ E+
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 1651 LSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQ 1710
L+++ E+ + + L K ++ L K+ LA +L Q +E+ +++ L+ Q
Sbjct: 1208 LTEQLEQFKRAKANLDKN-------KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 1711 EKELAQELEELEWDMEELSWKEEEL-----------NQEEGKLVEEKKKLAEEEEALAWQ 1759
+EL + + E EL+ K +L N+ EGK ++ K +A L
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 1760 REKLSEE-------ETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKL 1812
+E L EE TKL Q EE +++L + E E + QL + K KL
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 1813 AQKRERWINSMEELTKNKMILYQK-KNLAQEKKNLAQEKEKLAQRKENLLYNKERLT--- 1868
+ + +++E L + K ++ +NL Q+ + A +KL + K L + L
Sbjct: 1381 ----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436
Query: 1869 HSKKQLVQ-VKNKLGMFNKILAQ---VEEKLTQEKETV-IKKKEKLAETEKKLVQVEDSL 1923
+++QLV ++ K F+++LA+ + K E++ + +EK + +E++L
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496
Query: 1924 AKKQEKLAQEKMKLALEKAMVQGKKRLRGEL-DIAKEEKALNLEMKRLAEEKMRLVEGKE 1982
K+E KM A + +V K + + ++ K ++AL +M+ E K +L E ++
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---EMKTQLEELED 1553
Query: 1983 TLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQ 2042
L E + + M ++ + FER L ++ + R L + E + +LE R Q
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLHEY-ETELEDERKQ 1611
Query: 2043 RIFVQGQRKLAKASRK--------LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEE 2094
R +K + K IK RE K+ KL +K Q+ D R +++E
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA-SRDE 1670
Query: 2095 IKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMI 2154
I T + K + Q + D+ + + K+++L K+E LA ++ +
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE---------LAEELASSL 1721
Query: 2155 NKEEKMTEEESKLARKHSEVILDDEEEGGIEE----------EEVIPFLKRRWRKRKEAK 2204
+ + +E+ +L + +++ + EEE G E ++ +R A+
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 2205 RGDKPKEKFSSQVDEVESEEHFSE-----EMESLLDELEKQESLSSE--EEEEREEEEER 2257
+ + +++ Q E+ S+ H E + +S + LE + + E E+E RE ++
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE--KQA 1839
Query: 2258 EEEEVREEEEERKE---EEEGEEKQVE--KEEEEKKKKKKEKKKEEVQEKEEVFEEKEEI 2312
+ +++++++ KE + E E K E KE+ EK + ++ K +++E E EE + I
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE---EESQRI 1896
Query: 2313 MSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLR 2361
+ +E E + ++ EV+ K L++ + RR R
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGR 1945
Score = 147 bits (370), Expect = 2e-34
Identities = 194/869 (22%), Positives = 386/869 (44%), Gaps = 74/869 (8%)
Query: 1577 IHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGK 1636
I R A K R + +L + + L Q RQ +EE + + ++ T++ ++ A+ E K
Sbjct: 819 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ--EEEMQAKEDELQKTKERQQKAENELK 876
Query: 1637 FAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQK 1696
L Q+ +L++E L ++ + + + + +LA K +L E+ + + +
Sbjct: 877 ------ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 930
Query: 1697 VEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEAL 1756
+EE R Q L + K++AQ++ +LE +EE ++L E+ + KKL +E +
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 1757 AWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKR 1816
Q KLS+E L EE + LA+ +EK + +L K E +I + +K
Sbjct: 991 DDQNNKLSKERKLL---EERISDLTTNLAEEEEK-AKNLTKLKNKHESMISELEVRLKKE 1046
Query: 1817 ERWINSMEELTKNKMILYQ-----KKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSK 1871
E+ S +EL K K L + +A + +A+ K +LA+++E L RL
Sbjct: 1047 EK---SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 1872 KQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKK-------EKLAETEKKLVQVEDSLA 1924
Q K+ ++ ++E L E+ K + E+L + +L DS A
Sbjct: 1104 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 1925 KKQEKLAQEKMKL-ALEKAMVQGKKRLRGELDIAKEEKA-----LNLEMKRLAEEKMRLV 1978
+QE A+ + ++ L+KA+ + + ++ +++ A L ++++ K L
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 1979 EGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKIL---------------LHEDRI 2023
+ K+TL K R + Q +QE+ +K LE ++ L++
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 2024 LAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKL 2083
E E G L G+ I + + +A S +L +E L +E + + L++L
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKL--AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Query: 2084 TRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQ 2143
+ L + + + K+ L L+I+ S K DF+ L + +K+ ++
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401
Query: 2144 RKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEA 2203
L + +K+ + +++L ++ ++++D + + +++ L+++ RK +
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-----NQRQLVSNLEKKQRKFDQL 1456
Query: 2204 KRGDKP-KEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEE- 2261
+K K++ + D E+E +E ++L +E+L ++EE ER + + E E
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAR-EKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 2262 -VREEEEERKEEEEGEE-KQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE---- 2315
V +++ K E E+ K+ + + E+ K + E+ ++E+Q E+ E M
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 2316 -EETESLSDEEEEEESCSLEEEV-DREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGV 2373
E DE+ EE+ L+ ++ + E E+ + KQ L +K L G + L L+
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE-LQAD 1634
Query: 2374 PHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
KGR + +K+L +MK+
Sbjct: 1635 SAIKGR-------EEAIKQLRKLQAQMKD 1656
Score = 33.1 bits (74), Expect = 4.1
Identities = 42/232 (18%), Positives = 96/232 (41%), Gaps = 16/232 (6%)
Query: 972 IKTLSLMAEIGIHSRTSLL-QLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQV 1030
+K L L A+ I R + QL + Q ++ Q+++ + A + + + +
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1685
Query: 1031 E---QRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQA 1087
E +L E+L + R K A + EL SSL ++ + ++ Q +
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 1088 GVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVI 1147
++ + + + + + ++Q+S +E TE + + E++ + +
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLS-------NELATERSTAQKNESARQQLERQNKELR 1798
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDK-----RDKKATAQKLKKKHKK 1194
+++ K K IA ++ ++ ++ R+K+A + LK+K KK
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 174 bits (442), Expect = 9e-43
Identities = 234/1047 (22%), Positives = 463/1047 (44%), Gaps = 127/1047 (12%)
Query: 1483 EEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD-- 1540
+E +++ E ++L Q +L+ E+ +LQE + + E + + E + +K+Q+ ++
Sbjct: 872 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 931
Query: 1541 -EEEVTLEEEVSR------EGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEER 1593
E E LEEE R E ++ QQ+ + + ++EE R++ + EK A+ +
Sbjct: 932 HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKI 987
Query: 1594 KLAQEEEKLAQEERQLAQEERKLAQAYVKITQ----DDREMAQAEGKFAQKEETLAQRGE 1649
K ++E + ++ +ERKL + + ++ E A+ K K E++ E
Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Query: 1650 KLSQEAEKLAQKRKKLAKKWEKVARE-EEKLAKKGGKLAEVKNILAQKVEELPQREQNLD 1708
++ EK Q+ +KL +K E A + E++A ++AE+K LA+K EEL LD
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 1709 ---WQEKELAQELEELEWDMEELSWKEEELNQE---EGKLVEEKKKLAEEEEALAWQREK 1762
Q+ +++ ELE + +L +E+L+ E K ++K+ L EE EAL + +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDL---QEDLDSERAARNKAEKQKRDLGEELEAL---KTE 1161
Query: 1763 LSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINS 1822
L + A ++EL + ++++ K+ + EE Q+ E + K AQ E
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETR---SHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 1823 MEELTKNKMIL-YQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL 1881
+E+ + K L K+ L +E +LA E L Q K+ + + K++L + Q+ ++++K
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQSKC 1275
Query: 1882 GMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE- 1940
+ A++ +K+ + + V L E E K +++ +A +L Q+ +L E
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQELLQEE 1334
Query: 1941 ---KAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRK 1997
K V K R + +E +L ++ E K L TL+ + + +
Sbjct: 1335 TRQKLNVSTKLR-----QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 1998 MTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQR--------IFVQGQ 2049
+ L E K +++I E+ EE A KLE T+ + + + Q
Sbjct: 1390 FASTVEALEEGKKRFQKEI---ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 2050 RKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRAL---FV 2106
R+L K +K + L E ++ K + R E + ++E K + RAL
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISS--KYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 2107 KERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESK 2166
+ L L + D + ++ K+ +L + +R L +M M + E++ +E
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE--- 1561
Query: 2167 LARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK--RGDKPKEKFSSQVDEVESE- 2223
L E+ + E + LK ++ + +A+ + ++ + + Q+ E E+E
Sbjct: 1562 ---------LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 2224 ----------EHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273
+++E L +LE Q + + EE ++ + + ++++ + E ++
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 2274 EG-EEKQVEKEEEEKKKKKKEKKKEEVQE--------KEEVFEEKEEIMSEEETESLS-- 2322
+E +E EKK K E ++QE +++ EKEE ++EE SLS
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE-LAEELASSLSGR 1731
Query: 2323 -----------------DEEEEEESCSLEEEVDREKEILKKEKQF-------KLQEQRRK 2358
+EE EEE ++E DR ++ ++ +Q + Q+ +
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 2359 SLRGR-ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWED 2417
S R + ER LR H A++ KS + L + +++E+ EKQ + +
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVK-SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 2418 KKATVVEIPRKFLGTMDKEREVMGKYE 2444
K ++ ++ L ++ ER++ +Y+
Sbjct: 1851 LKQKDKKL-KEILLQVEDERKMAEQYK 1876
Score = 164 bits (414), Expect = 2e-39
Identities = 248/1129 (21%), Positives = 488/1129 (43%), Gaps = 144/1129 (12%)
Query: 1345 REEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKE---EKKTFQKSPK 1401
R+EE+ Q K ++ +E Q + K + + +T K + +++ E + + ++ +
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 1402 QGRKAVQKERKVGKIKREMT---KEERDMSEEVE--------EMATLEEKVVKQEG--KL 1448
+ K++++ +I EM +EE D ++++ +M LEE++ ++E +
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 1449 VMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEK------RLLQEEEKLHQAGEK 1502
+ +E+ + KK DE + + K K K E+ L +EEEK +
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035
Query: 1503 LSPEEEMLQE-DKKLKWEEWKQVWENMLSSKS---------------------KEQQYKD 1540
+ E M+ E + +LK EE + L K K Q K
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1095
Query: 1541 EEEVT-----LEEEVSREGEEKEQQVTEEQRHI---QEEHKWARIHRKRARAEKKRAQEE 1592
EEE+ L++E++++ ++ + E + HI QE+ R R +A +K+ EE
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154
Query: 1593 RKLAQEEEKLAQEERQLAQEERKLAQAYVKITQD--DREMAQAEGKFAQKEETLAQRGEK 1650
+ + E + + QE R + V + + D E E + + + AQ E+
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 1651 LSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQ 1710
L+++ E+ + + L K ++ L K+ LA +L Q +E+ +++ L+ Q
Sbjct: 1215 LTEQLEQFKRAKANLDKN-------KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 1711 EKELAQELEELEWDMEELSWKEEEL-----------NQEEGKLVEEKKKLAEEEEALAWQ 1759
+EL + + E EL+ K +L N+ EGK ++ K +A L
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 1760 REKLSEE-------ETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKL 1812
+E L EE TKL Q EE +++L + E E + QL + K KL
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 1813 AQKRERWINSMEELTKNKMILYQK-KNLAQEKKNLAQEKEKLAQRKENLLYNKERLT--- 1868
+ + +++E L + K ++ +NL Q+ + A +KL + K L + L
Sbjct: 1388 ----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443
Query: 1869 HSKKQLVQ-VKNKLGMFNKILAQ---VEEKLTQEKETV-IKKKEKLAETEKKLVQVEDSL 1923
+++QLV ++ K F+++LA+ + K E++ + +EK + +E++L
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503
Query: 1924 AKKQEKLAQEKMKLALEKAMVQGKKRLRGEL-DIAKEEKALNLEMKRLAEEKMRLVEGKE 1982
K+E KM A + +V K + + ++ K ++AL +M+ E K +L E ++
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---EMKTQLEELED 1560
Query: 1983 TLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQ 2042
L E + + M ++ + FER L ++ + R L + E + +LE R Q
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLHEY-ETELEDERKQ 1618
Query: 2043 RIFVQGQRKLAKASRK--------LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEE 2094
R +K + K IK RE K+ KL +K Q+ D R +++E
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA-SRDE 1677
Query: 2095 IKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMI 2154
I T + K + Q + D+ + + K+++L K+E LA ++ +
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE---------LAEELASSL 1728
Query: 2155 NKEEKMTEEESKLARKHSEVILDDEEEGGIEE----------EEVIPFLKRRWRKRKEAK 2204
+ + +E+ +L + +++ + EEE G E ++ +R A+
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 2205 RGDKPKEKFSSQVDEVESEEHFSE-----EMESLLDELEKQESLSSE--EEEEREEEEER 2257
+ + +++ Q E+ S+ H E + +S + LE + + E E+E RE ++
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE--KQA 1846
Query: 2258 EEEEVREEEEERKE---EEEGEEKQVE--KEEEEKKKKKKEKKKEEVQEKEEVFEEKEEI 2312
+ +++++++ KE + E E K E KE+ EK + ++ K +++E E EE + I
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE---EESQRI 1903
Query: 2313 MSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLR 2361
+ +E E + ++ EV+ K L++ + RR R
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGR 1952
Score = 147 bits (370), Expect = 2e-34
Identities = 194/869 (22%), Positives = 386/869 (44%), Gaps = 74/869 (8%)
Query: 1577 IHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGK 1636
I R A K R + +L + + L Q RQ +EE + + ++ T++ ++ A+ E K
Sbjct: 826 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ--EEEMQAKEDELQKTKERQQKAENELK 883
Query: 1637 FAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQK 1696
L Q+ +L++E L ++ + + + + +LA K +L E+ + + +
Sbjct: 884 ------ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 937
Query: 1697 VEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEAL 1756
+EE R Q L + K++AQ++ +LE +EE ++L E+ + KKL +E +
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 1757 AWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKR 1816
Q KLS+E L EE + LA+ +EK + +L K E +I + +K
Sbjct: 998 DDQNNKLSKERKLL---EERISDLTTNLAEEEEK-AKNLTKLKNKHESMISELEVRLKKE 1053
Query: 1817 ERWINSMEELTKNKMILYQ-----KKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSK 1871
E+ S +EL K K L + +A + +A+ K +LA+++E L RL
Sbjct: 1054 EK---SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 1872 KQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKK-------EKLAETEKKLVQVEDSLA 1924
Q K+ ++ ++E L E+ K + E+L + +L DS A
Sbjct: 1111 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 1925 KKQEKLAQEKMKL-ALEKAMVQGKKRLRGELDIAKEEKA-----LNLEMKRLAEEKMRLV 1978
+QE A+ + ++ L+KA+ + + ++ +++ A L ++++ K L
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 1979 EGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKIL---------------LHEDRI 2023
+ K+TL K R + Q +QE+ +K LE ++ L++
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 2024 LAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKL 2083
E E G L G+ I + + +A S +L +E L +E + + L++L
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKL--AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 2084 TRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQ 2143
+ L + + + K+ L L+I+ S K DF+ L + +K+ ++
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408
Query: 2144 RKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEA 2203
L + +K+ + +++L ++ ++++D + + +++ L+++ RK +
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-----NQRQLVSNLEKKQRKFDQL 1463
Query: 2204 KRGDKP-KEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEE- 2261
+K K++ + D E+E +E ++L +E+L ++EE ER + + E E
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAR-EKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 2262 -VREEEEERKEEEEGEE-KQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE---- 2315
V +++ K E E+ K+ + + E+ K + E+ ++E+Q E+ E M
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 2316 -EETESLSDEEEEEESCSLEEEV-DREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGV 2373
E DE+ EE+ L+ ++ + E E+ + KQ L +K L G + L L+
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE-LQAD 1641
Query: 2374 PHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
KGR + +K+L +MK+
Sbjct: 1642 SAIKGR-------EEAIKQLRKLQAQMKD 1663
Score = 33.1 bits (74), Expect = 4.1
Identities = 42/232 (18%), Positives = 96/232 (41%), Gaps = 16/232 (6%)
Query: 972 IKTLSLMAEIGIHSRTSLL-QLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQV 1030
+K L L A+ I R + QL + Q ++ Q+++ + A + + + +
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1692
Query: 1031 E---QRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQA 1087
E +L E+L + R K A + EL SSL ++ + ++ Q +
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 1088 GVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVI 1147
++ + + + + + ++Q+S +E TE + + E++ + +
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLS-------NELATERSTAQKNESARQQLERQNKELR 1805
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDK-----RDKKATAQKLKKKHKK 1194
+++ K K IA ++ ++ ++ R+K+A + LK+K KK
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 174 bits (442), Expect = 9e-43
Identities = 234/1047 (22%), Positives = 463/1047 (44%), Gaps = 127/1047 (12%)
Query: 1483 EEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD-- 1540
+E +++ E ++L Q +L+ E+ +LQE + + E + + E + +K+Q+ ++
Sbjct: 872 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 931
Query: 1541 -EEEVTLEEEVSR------EGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEER 1593
E E LEEE R E ++ QQ+ + + ++EE R++ + EK A+ +
Sbjct: 932 HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKI 987
Query: 1594 KLAQEEEKLAQEERQLAQEERKLAQAYVKITQ----DDREMAQAEGKFAQKEETLAQRGE 1649
K ++E + ++ +ERKL + + ++ E A+ K K E++ E
Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Query: 1650 KLSQEAEKLAQKRKKLAKKWEKVARE-EEKLAKKGGKLAEVKNILAQKVEELPQREQNLD 1708
++ EK Q+ +KL +K E A + E++A ++AE+K LA+K EEL LD
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 1709 ---WQEKELAQELEELEWDMEELSWKEEELNQE---EGKLVEEKKKLAEEEEALAWQREK 1762
Q+ +++ ELE + +L +E+L+ E K ++K+ L EE EAL + +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDL---QEDLDSERAARNKAEKQKRDLGEELEAL---KTE 1161
Query: 1763 LSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINS 1822
L + A ++EL + ++++ K+ + EE Q+ E + K AQ E
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETR---SHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 1823 MEELTKNKMIL-YQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL 1881
+E+ + K L K+ L +E +LA E L Q K+ + + K++L + Q+ ++++K
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQSKC 1275
Query: 1882 GMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE- 1940
+ A++ +K+ + + V L E E K +++ +A +L Q+ +L E
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQELLQEE 1334
Query: 1941 ---KAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRK 1997
K V K R + +E +L ++ E K L TL+ + + +
Sbjct: 1335 TRQKLNVSTKLR-----QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 1998 MTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQR--------IFVQGQ 2049
+ L E K +++I E+ EE A KLE T+ + + + Q
Sbjct: 1390 FASTVEALEEGKKRFQKEI---ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 2050 RKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRAL---FV 2106
R+L K +K + L E ++ K + R E + ++E K + RAL
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISS--KYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 2107 KERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESK 2166
+ L L + D + ++ K+ +L + +R L +M M + E++ +E
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE--- 1561
Query: 2167 LARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK--RGDKPKEKFSSQVDEVESE- 2223
L E+ + E + LK ++ + +A+ + ++ + + Q+ E E+E
Sbjct: 1562 ---------LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 2224 ----------EHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273
+++E L +LE Q + + EE ++ + + ++++ + E ++
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 2274 EG-EEKQVEKEEEEKKKKKKEKKKEEVQE--------KEEVFEEKEEIMSEEETESLS-- 2322
+E +E EKK K E ++QE +++ EKEE ++EE SLS
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE-LAEELASSLSGR 1731
Query: 2323 -----------------DEEEEEESCSLEEEVDREKEILKKEKQF-------KLQEQRRK 2358
+EE EEE ++E DR ++ ++ +Q + Q+ +
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 2359 SLRGR-ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWED 2417
S R + ER LR H A++ KS + L + +++E+ EKQ + +
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVK-SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 2418 KKATVVEIPRKFLGTMDKEREVMGKYE 2444
K ++ ++ L ++ ER++ +Y+
Sbjct: 1851 LKQKDKKL-KEILLQVEDERKMAEQYK 1876
Score = 167 bits (423), Expect = 1e-40
Identities = 245/1108 (22%), Positives = 491/1108 (44%), Gaps = 134/1108 (12%)
Query: 1345 REEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKE---EKKTFQKSPK 1401
R+EE+ Q K ++ +E Q + K + + +T K + +++ E + + ++ +
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 1402 QGRKAVQKERKVGKIKREMT---KEERDMSEEVE--------EMATLEEKVVKQEG--KL 1448
+ K++++ +I EM +EE D ++++ +M LEE++ ++E +
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 1449 VMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEK------RLLQEEEKLHQAGEK 1502
+ +E+ + KK DE + + K K K E+ L +EEEK +
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035
Query: 1503 LSPEEEMLQE-DKKLKWEEWKQVWENMLSSKS---------------------KEQQYKD 1540
+ E M+ E + +LK EE + L K K Q K
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1095
Query: 1541 EEEVT-----LEEEVSREGEEKEQQVTEEQRHI---QEEHKWARIHRKRARAEKKRAQEE 1592
EEE+ L++E++++ ++ + E + HI QE+ R R +A +K+ EE
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154
Query: 1593 RKLAQEEEKLAQEERQLAQEERKLAQAYVKITQD--DREMAQAEGKFAQKEETLAQRGEK 1650
+ + E + + QE R + V + + D E E + + + AQ E+
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 1651 LSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQ 1710
L+++ E+ + + L K ++ L K+ LA +L Q +E+ +++ L+ Q
Sbjct: 1215 LTEQLEQFKRAKANLDKN-------KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 1711 EKELAQELEELEWDMEELSWKEEEL-----------NQEEGKLVEEKKKLAEEEEALAWQ 1759
+EL + + E EL+ K +L N+ EGK ++ K +A L
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 1760 REKLSEE-------ETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKL 1812
+E L EE TKL Q EE +++L + E E + QL + K KL
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 1813 AQKRERWINSMEELTKNKMILYQK-KNLAQEKKNLAQEKEKLAQRKENLLYNKERLT--- 1868
+ + +++E L + K ++ +NL Q+ + A +KL + K L + L
Sbjct: 1388 ----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443
Query: 1869 HSKKQLVQ-VKNKLGMFNKILAQ---VEEKLTQEKETV-IKKKEKLAETEKKLVQVEDSL 1923
+++QLV ++ K F+++LA+ + K E++ + +EK + +E++L
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503
Query: 1924 AKKQEKLAQEKMKLALEKAMVQGKKRLRGEL-DIAKEEKALNLEMKRLAEEKMRLVEGKE 1982
K+E KM A + +V K + + ++ K ++AL +M+ E K +L E ++
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---EMKTQLEELED 1560
Query: 1983 TLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQ 2042
L E + + M ++ + FER L ++ + R L + E + +LE R Q
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLHEY-ETELEDERKQ 1618
Query: 2043 RIFVQGQRKLAKASRK--------LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEE 2094
R +K + K IK RE K+ KL +K Q+ D R +++E
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA-SRDE 1677
Query: 2095 IKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMI 2154
I T + K + Q + D+ + + K+++L K+E LA ++ +
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE---------LAEELASSL 1728
Query: 2155 NKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFS 2214
+ + +E+ +L + +++ + EEE G E + R+ ++ E + E+ +
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQG--NMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 2215 SQVDEVESE--EHFSEEMESLLDELE-----KQESLSSEEEEEREEEEEREEEEVREEEE 2267
+Q +E + E ++E+ S L E+E K +S + E + + EE+ E+E RE++
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846
Query: 2268 ERK--EEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEI-MSEEETESLSD- 2323
K ++++ + K++ + E+++K ++ K++ + V + K ++ +EEE++ ++
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 2324 ----EEEEEESCSLEEEVDREKEILKKE 2347
+ E +E+ E + RE LK +
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 147 bits (370), Expect = 2e-34
Identities = 194/869 (22%), Positives = 386/869 (44%), Gaps = 74/869 (8%)
Query: 1577 IHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGK 1636
I R A K R + +L + + L Q RQ +EE + + ++ T++ ++ A+ E K
Sbjct: 826 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ--EEEMQAKEDELQKTKERQQKAENELK 883
Query: 1637 FAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQK 1696
L Q+ +L++E L ++ + + + + +LA K +L E+ + + +
Sbjct: 884 ------ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 937
Query: 1697 VEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEAL 1756
+EE R Q L + K++AQ++ +LE +EE ++L E+ + KKL +E +
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 1757 AWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKR 1816
Q KLS+E L EE + LA+ +EK + +L K E +I + +K
Sbjct: 998 DDQNNKLSKERKLL---EERISDLTTNLAEEEEK-AKNLTKLKNKHESMISELEVRLKKE 1053
Query: 1817 ERWINSMEELTKNKMILYQ-----KKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSK 1871
E+ S +EL K K L + +A + +A+ K +LA+++E L RL
Sbjct: 1054 EK---SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 1872 KQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKK-------EKLAETEKKLVQVEDSLA 1924
Q K+ ++ ++E L E+ K + E+L + +L DS A
Sbjct: 1111 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 1925 KKQEKLAQEKMKL-ALEKAMVQGKKRLRGELDIAKEEKA-----LNLEMKRLAEEKMRLV 1978
+QE A+ + ++ L+KA+ + + ++ +++ A L ++++ K L
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 1979 EGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKIL---------------LHEDRI 2023
+ K+TL K R + Q +QE+ +K LE ++ L++
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 2024 LAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKL 2083
E E G L G+ I + + +A S +L +E L +E + + L++L
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKL--AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 2084 TRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQ 2143
+ L + + + K+ L L+I+ S K DF+ L + +K+ ++
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408
Query: 2144 RKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEA 2203
L + +K+ + +++L ++ ++++D + + +++ L+++ RK +
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-----NQRQLVSNLEKKQRKFDQL 1463
Query: 2204 KRGDKP-KEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEE- 2261
+K K++ + D E+E +E ++L +E+L ++EE ER + + E E
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAR-EKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 2262 -VREEEEERKEEEEGEE-KQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE---- 2315
V +++ K E E+ K+ + + E+ K + E+ ++E+Q E+ E M
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 2316 -EETESLSDEEEEEESCSLEEEV-DREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGV 2373
E DE+ EE+ L+ ++ + E E+ + KQ L +K L G + L L+
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE-LQAD 1641
Query: 2374 PHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
KGR + +K+L +MK+
Sbjct: 1642 SAIKGR-------EEAIKQLRKLQAQMKD 1663
Score = 33.1 bits (74), Expect = 4.1
Identities = 42/232 (18%), Positives = 96/232 (41%), Gaps = 16/232 (6%)
Query: 972 IKTLSLMAEIGIHSRTSLL-QLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQV 1030
+K L L A+ I R + QL + Q ++ Q+++ + A + + + +
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1692
Query: 1031 E---QRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQA 1087
E +L E+L + R K A + EL SSL ++ + ++ Q +
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 1088 GVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVI 1147
++ + + + + + ++Q+S +E TE + + E++ + +
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLS-------NELATERSTAQKNESARQQLERQNKELR 1805
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDK-----RDKKATAQKLKKKHKK 1194
+++ K K IA ++ ++ ++ R+K+A + LK+K KK
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 174 bits (442), Expect = 9e-43
Identities = 234/1047 (22%), Positives = 463/1047 (44%), Gaps = 127/1047 (12%)
Query: 1483 EEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD-- 1540
+E +++ E ++L Q +L+ E+ +LQE + + E + + E + +K+Q+ ++
Sbjct: 865 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 924
Query: 1541 -EEEVTLEEEVSR------EGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEER 1593
E E LEEE R E ++ QQ+ + + ++EE R++ + EK A+ +
Sbjct: 925 HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKI 980
Query: 1594 KLAQEEEKLAQEERQLAQEERKLAQAYVKITQ----DDREMAQAEGKFAQKEETLAQRGE 1649
K ++E + ++ +ERKL + + ++ E A+ K K E++ E
Sbjct: 981 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Query: 1650 KLSQEAEKLAQKRKKLAKKWEKVARE-EEKLAKKGGKLAEVKNILAQKVEELPQREQNLD 1708
++ EK Q+ +KL +K E A + E++A ++AE+K LA+K EEL LD
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 1709 ---WQEKELAQELEELEWDMEELSWKEEELNQE---EGKLVEEKKKLAEEEEALAWQREK 1762
Q+ +++ ELE + +L +E+L+ E K ++K+ L EE EAL + +
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDL---QEDLDSERAARNKAEKQKRDLGEELEAL---KTE 1154
Query: 1763 LSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINS 1822
L + A ++EL + ++++ K+ + EE Q+ E + K AQ E
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETR---SHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 1823 MEELTKNKMIL-YQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL 1881
+E+ + K L K+ L +E +LA E L Q K+ + + K++L + Q+ ++++K
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQSKC 1268
Query: 1882 GMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE- 1940
+ A++ +K+ + + V L E E K +++ +A +L Q+ +L E
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQELLQEE 1327
Query: 1941 ---KAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRK 1997
K V K R + +E +L ++ E K L TL+ + + +
Sbjct: 1328 TRQKLNVSTKLR-----QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 1998 MTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQR--------IFVQGQ 2049
+ L E K +++I E+ EE A KLE T+ + + + Q
Sbjct: 1383 FASTVEALEEGKKRFQKEI---ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 2050 RKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRAL---FV 2106
R+L K +K + L E ++ K + R E + ++E K + RAL
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISS--KYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 2107 KERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESK 2166
+ L L + D + ++ K+ +L + +R L +M M + E++ +E
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE--- 1554
Query: 2167 LARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK--RGDKPKEKFSSQVDEVESE- 2223
L E+ + E + LK ++ + +A+ + ++ + + Q+ E E+E
Sbjct: 1555 ---------LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 2224 ----------EHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273
+++E L +LE Q + + EE ++ + + ++++ + E ++
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 2274 EG-EEKQVEKEEEEKKKKKKEKKKEEVQE--------KEEVFEEKEEIMSEEETESLS-- 2322
+E +E EKK K E ++QE +++ EKEE ++EE SLS
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE-LAEELASSLSGR 1724
Query: 2323 -----------------DEEEEEESCSLEEEVDREKEILKKEKQF-------KLQEQRRK 2358
+EE EEE ++E DR ++ ++ +Q + Q+ +
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 2359 SLRGR-ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWED 2417
S R + ER LR H A++ KS + L + +++E+ EKQ + +
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVK-SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 2418 KKATVVEIPRKFLGTMDKEREVMGKYE 2444
K ++ ++ L ++ ER++ +Y+
Sbjct: 1844 LKQKDKKL-KEILLQVEDERKMAEQYK 1869
Score = 167 bits (423), Expect = 1e-40
Identities = 245/1108 (22%), Positives = 491/1108 (44%), Gaps = 134/1108 (12%)
Query: 1345 REEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKE---EKKTFQKSPK 1401
R+EE+ Q K ++ +E Q + K + + +T K + +++ E + + ++ +
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 1402 QGRKAVQKERKVGKIKREMT---KEERDMSEEVE--------EMATLEEKVVKQEG--KL 1448
+ K++++ +I EM +EE D ++++ +M LEE++ ++E +
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 1449 VMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEK------RLLQEEEKLHQAGEK 1502
+ +E+ + KK DE + + K K K E+ L +EEEK +
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028
Query: 1503 LSPEEEMLQE-DKKLKWEEWKQVWENMLSSKS---------------------KEQQYKD 1540
+ E M+ E + +LK EE + L K K Q K
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1088
Query: 1541 EEEVT-----LEEEVSREGEEKEQQVTEEQRHI---QEEHKWARIHRKRARAEKKRAQEE 1592
EEE+ L++E++++ ++ + E + HI QE+ R R +A +K+ EE
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147
Query: 1593 RKLAQEEEKLAQEERQLAQEERKLAQAYVKITQD--DREMAQAEGKFAQKEETLAQRGEK 1650
+ + E + + QE R + V + + D E E + + + AQ E+
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 1651 LSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQ 1710
L+++ E+ + + L K ++ L K+ LA +L Q +E+ +++ L+ Q
Sbjct: 1208 LTEQLEQFKRAKANLDKN-------KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 1711 EKELAQELEELEWDMEELSWKEEEL-----------NQEEGKLVEEKKKLAEEEEALAWQ 1759
+EL + + E EL+ K +L N+ EGK ++ K +A L
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 1760 REKLSEE-------ETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKL 1812
+E L EE TKL Q EE +++L + E E + QL + K KL
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 1813 AQKRERWINSMEELTKNKMILYQK-KNLAQEKKNLAQEKEKLAQRKENLLYNKERLT--- 1868
+ + +++E L + K ++ +NL Q+ + A +KL + K L + L
Sbjct: 1381 ----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436
Query: 1869 HSKKQLVQ-VKNKLGMFNKILAQ---VEEKLTQEKETV-IKKKEKLAETEKKLVQVEDSL 1923
+++QLV ++ K F+++LA+ + K E++ + +EK + +E++L
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496
Query: 1924 AKKQEKLAQEKMKLALEKAMVQGKKRLRGEL-DIAKEEKALNLEMKRLAEEKMRLVEGKE 1982
K+E KM A + +V K + + ++ K ++AL +M+ E K +L E ++
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---EMKTQLEELED 1553
Query: 1983 TLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQ 2042
L E + + M ++ + FER L ++ + R L + E + +LE R Q
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLHEY-ETELEDERKQ 1611
Query: 2043 RIFVQGQRKLAKASRK--------LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEE 2094
R +K + K IK RE K+ KL +K Q+ D R +++E
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA-SRDE 1670
Query: 2095 IKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMI 2154
I T + K + Q + D+ + + K+++L K+E LA ++ +
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE---------LAEELASSL 1721
Query: 2155 NKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFS 2214
+ + +E+ +L + +++ + EEE G E + R+ ++ E + E+ +
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQG--NMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 2215 SQVDEVESE--EHFSEEMESLLDELE-----KQESLSSEEEEEREEEEEREEEEVREEEE 2267
+Q +E + E ++E+ S L E+E K +S + E + + EE+ E+E RE++
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839
Query: 2268 ERK--EEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEI-MSEEETESLSD- 2323
K ++++ + K++ + E+++K ++ K++ + V + K ++ +EEE++ ++
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 2324 ----EEEEEESCSLEEEVDREKEILKKE 2347
+ E +E+ E + RE LK +
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 147 bits (370), Expect = 2e-34
Identities = 194/869 (22%), Positives = 386/869 (44%), Gaps = 74/869 (8%)
Query: 1577 IHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGK 1636
I R A K R + +L + + L Q RQ +EE + + ++ T++ ++ A+ E K
Sbjct: 819 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ--EEEMQAKEDELQKTKERQQKAENELK 876
Query: 1637 FAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQK 1696
L Q+ +L++E L ++ + + + + +LA K +L E+ + + +
Sbjct: 877 ------ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 930
Query: 1697 VEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEAL 1756
+EE R Q L + K++AQ++ +LE +EE ++L E+ + KKL +E +
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 1757 AWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKR 1816
Q KLS+E L EE + LA+ +EK + +L K E +I + +K
Sbjct: 991 DDQNNKLSKERKLL---EERISDLTTNLAEEEEK-AKNLTKLKNKHESMISELEVRLKKE 1046
Query: 1817 ERWINSMEELTKNKMILYQ-----KKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSK 1871
E+ S +EL K K L + +A + +A+ K +LA+++E L RL
Sbjct: 1047 EK---SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 1872 KQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKK-------EKLAETEKKLVQVEDSLA 1924
Q K+ ++ ++E L E+ K + E+L + +L DS A
Sbjct: 1104 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 1925 KKQEKLAQEKMKL-ALEKAMVQGKKRLRGELDIAKEEKA-----LNLEMKRLAEEKMRLV 1978
+QE A+ + ++ L+KA+ + + ++ +++ A L ++++ K L
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 1979 EGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKIL---------------LHEDRI 2023
+ K+TL K R + Q +QE+ +K LE ++ L++
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 2024 LAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKL 2083
E E G L G+ I + + +A S +L +E L +E + + L++L
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKL--AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Query: 2084 TRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQ 2143
+ L + + + K+ L L+I+ S K DF+ L + +K+ ++
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401
Query: 2144 RKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEA 2203
L + +K+ + +++L ++ ++++D + + +++ L+++ RK +
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-----NQRQLVSNLEKKQRKFDQL 1456
Query: 2204 KRGDKP-KEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEE- 2261
+K K++ + D E+E +E ++L +E+L ++EE ER + + E E
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAR-EKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 2262 -VREEEEERKEEEEGEE-KQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE---- 2315
V +++ K E E+ K+ + + E+ K + E+ ++E+Q E+ E M
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 2316 -EETESLSDEEEEEESCSLEEEV-DREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGV 2373
E DE+ EE+ L+ ++ + E E+ + KQ L +K L G + L L+
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE-LQAD 1634
Query: 2374 PHGKGRAIRLGVLKSPLKKLMSTALEMKE 2402
KGR + +K+L +MK+
Sbjct: 1635 SAIKGR-------EEAIKQLRKLQAQMKD 1656
Score = 33.1 bits (74), Expect = 4.1
Identities = 42/232 (18%), Positives = 96/232 (41%), Gaps = 16/232 (6%)
Query: 972 IKTLSLMAEIGIHSRTSLL-QLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQV 1030
+K L L A+ I R + QL + Q ++ Q+++ + A + + + +
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1685
Query: 1031 E---QRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQA 1087
E +L E+L + R K A + EL SSL ++ + ++ Q +
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 1088 GVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVI 1147
++ + + + + + ++Q+S +E TE + + E++ + +
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLS-------NELATERSTAQKNESARQQLERQNKELR 1798
Query: 1148 KLSKDVDSQEKDISKDHIALTLKRLQKIRDK-----RDKKATAQKLKKKHKK 1194
+++ K K IA ++ ++ ++ R+K+A + LK+K KK
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sapiens]
Length = 570
Score = 171 bits (434), Expect = 7e-42
Identities = 125/490 (25%), Positives = 266/490 (54%), Gaps = 44/490 (8%)
Query: 1338 RHKEVMPREEEQAQKKARDMLGLEET--QVILKKGKKVIFLEPGNVTMGKEISKKEEKKT 1395
+H+E + RE E AQ + +L ++T Q+ L + + G IS+ +
Sbjct: 104 QHQEALRRELE-AQVQTIRILTCQKTELQMALYYSQHAVKQLEGEAR--DLISRLHDSWK 160
Query: 1396 FQKSPKQGRKAVQ-KERKVGKIKREMTKEERDMSEEVEEMAT----LEEKVVKQEGKLVM 1450
F +Q AV +++K + E+TKE +S E+ L+EK K + KL +
Sbjct: 161 FAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQL 220
Query: 1451 IERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEK-RLLQEEEKLHQAGEKLSPEEEM 1509
+E S E + + K K + E+ +LL +++L + L E +
Sbjct: 221 VESEKS----------------EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 264
Query: 1510 LQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQ 1569
+ + + EE ++W N L+ + +E+ ++ EE++ EE +E EEK ++ E+ R Q
Sbjct: 265 VSAKLQAQVEE-NELW-NRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRR-Q 321
Query: 1570 EEHKWARIHRKRARAE------------KKRAQEERKLAQEEEKLAQEERQLAQEERKLA 1617
EE W + + R + E +++ E+ K+ ++EEK +EE+ QE+R+
Sbjct: 322 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 381
Query: 1618 QAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEE 1677
+A K+ + + ++ + E K ++EE + ++ EK+ ++ EK+ ++ +++ ++ EK+ R+EE
Sbjct: 382 EA--KMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439
Query: 1678 KLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQ 1737
K+ ++ K+ E + + ++ E + ++E+ + QE ++ ++ +++ E++ +EE++ +
Sbjct: 440 KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499
Query: 1738 EEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEER 1797
+E K+ E+++K+ E+EE + Q EK+ E+E K+ ++EE + +++EK+ + +EKM E+E R
Sbjct: 500 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVR 559
Query: 1798 LGRKREQLIE 1807
L ++ E++ E
Sbjct: 560 LRQQEEKMQE 569
Score = 161 bits (408), Expect = 8e-39
Identities = 108/435 (24%), Positives = 248/435 (57%), Gaps = 48/435 (11%)
Query: 1520 EWKQVWENMLSSKSKEQQYKDE---EEVTLEEEVSR------EGEEKEQQVTEEQRHIQE 1570
E +Q + + K K +Y +E E L E+ R E +EK ++ E+ + ++
Sbjct: 164 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 223
Query: 1571 EHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREM 1630
E +++ K E KR E KL +++L E L +E + ++ A ++ ++ E+
Sbjct: 224 EKSEIQLNVK----ELKRKLERAKLLLPQQQLQAEADHLGKELQSVS-AKLQAQVEENEL 278
Query: 1631 AQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVK 1690
+ Q+EE + ++ EK+ + EK+ ++ +K+ ++ EK+ R+EE + +K
Sbjct: 279 WNRLNQ--QQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEK-------- 328
Query: 1691 NILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLA 1750
EE +R++ + W+++E +ELEE + E++ ++EE QEE K+ E++K+
Sbjct: 329 -------EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR-EQEEKRQEEEKIREQEKR-- 378
Query: 1751 EEEEALAW-QREKLSEEETKLAQEEELLIQEKEKLAQHKEKM-------PEEEERLGRKR 1802
+E+EA W Q EK+ E+E K+ ++EE++ +++EK+ + +EKM E+EE++ R+
Sbjct: 379 QEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQE 438
Query: 1803 EQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLY 1862
E++ E++ K+ ++ E+ I EE M+ Q++ + +++ + +++ K+ +++E +
Sbjct: 439 EKIREQEKKIREQEEK-IREQEE-----MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRR 492
Query: 1863 NKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS 1922
+E++ +K++ + + K+ +++ + EEK+ +++E + +++EK+ E E+K+ + E+
Sbjct: 493 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 552
Query: 1923 LAKKQEKLAQEKMKL 1937
+ +++ +L Q++ K+
Sbjct: 553 MREQEVRLRQQEEKM 567
Score = 155 bits (392), Expect = 5e-37
Identities = 115/492 (23%), Positives = 257/492 (52%), Gaps = 52/492 (10%)
Query: 1422 KEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRK----- 1476
++E+ S + +E E + Q +++ ++T + KQ+ GE R
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 1477 --SWK------------AWKEEWEKRLLQEEEKLHQA-----------GEKLSPEEEMLQ 1511
SWK A +++ R ++E K A E+L + LQ
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 215
Query: 1512 EDKKLKWEEWKQVWENMLSSKSKEQQYKDE-EEVTLEEEVSREGEEKEQQVTEEQRHIQE 1570
E +L E ++ N+ K K ++ K + L+ E G+E + + Q ++E
Sbjct: 216 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 275
Query: 1571 EHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREM 1630
W R+++ Q+E K+ ++EEK+ + E ++ ++E K+ + K+ + + M
Sbjct: 276 NELWNRLNQ----------QQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMM 325
Query: 1631 AQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVK 1690
+ E K ++EE + ++ EK+ + EK+ +++K+ ++ EK R+EE+ ++ K E +
Sbjct: 326 WEKEEKMRRQEEMMWEKEEKIRELEEKM-HEQEKIREQEEK--RQEEEKIREQEKRQEQE 382
Query: 1691 NILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWK-EEELNQEEGKLVEEKKKL 1749
+ ++ E++ ++E+ + QE E+ QE EE + EE W+ EEE+ ++E K+ +++K+
Sbjct: 383 AKMWRQEEKIREQEEKIREQE-EMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKI 441
Query: 1750 AEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKK 1809
E+E+ + Q EK+ E+E + ++EE + +++ K+ + + KM E+EE++ R+ E++ E++
Sbjct: 442 REQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQE 501
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
K+ ++ E+ I EE M+ Q++ + ++++ + +++EK+ +++E + +E++
Sbjct: 502 KKIREQEEK-IREQEE-----MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMRE 555
Query: 1870 SKKQLVQVKNKL 1881
+ +L Q + K+
Sbjct: 556 QEVRLRQQEEKM 567
Score = 143 bits (361), Expect = 2e-33
Identities = 115/435 (26%), Positives = 235/435 (54%), Gaps = 43/435 (9%)
Query: 1934 KMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKR--LAEEKMRLVEGK--ETLSKGET 1989
+++ AL Q KK R ++ KE AL+LE+ R + +E+++ K E L E+
Sbjct: 164 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 223
Query: 1990 PETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME-ESEIAKGKLEFTRGQ---RIF 2045
++ Q + +++++L KL L ++ L E L E +S AK + + + R+
Sbjct: 224 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 283
Query: 2046 VQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALF 2105
Q + K+ + K+ ++ E + ++ KI + +K+ R E + ++E KM + + ++
Sbjct: 284 QQQEEKMWRQEEKIQEREEKIQEQE---EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 340
Query: 2106 VKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEES 2165
KE ++ + K+ +E + E + E++ R+Q K + +M +EEK+ E+E
Sbjct: 341 EKEEKIRELEEKMHEQE---KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 397
Query: 2166 KLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEH 2225
K+ R+ E++ + EE+ G +EE++ W + +E + + +EK Q +++ +E
Sbjct: 398 KI-REQEEMMQEQEEKMGEQEEKM-------WEQEEEMQ---EQEEKMRRQEEKIREQEK 446
Query: 2226 FSEEMESLLDELEKQESLSSEEEEEREEEEER---EEEEVREEEEERKEEEEGEEKQVEK 2282
E E +++ +QE + E+EE+ E+E + +E +++E+EE+ + +EE +
Sbjct: 447 KIREQE---EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE------KI 497
Query: 2283 EEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEE---EEEESCSLEEEVDR 2339
E+EKK +++E E+++E+EE+ +E+EE M E+E + EE E+EE +EE R
Sbjct: 498 REQEKKIREQE---EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMR 554
Query: 2340 EKEILKKEKQFKLQE 2354
E+E+ ++++ K+QE
Sbjct: 555 EQEVRLRQQEEKMQE 569
Score = 142 bits (358), Expect = 5e-33
Identities = 101/423 (23%), Positives = 229/423 (54%), Gaps = 28/423 (6%)
Query: 1595 LAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQE 1654
+A +++K + +L +E L+ + T D E+ + K +K + + ++
Sbjct: 172 VATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLN 231
Query: 1655 AEKLAQK--RKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEK 1712
++L +K R KL +++ E + L K+ L V L +VEE
Sbjct: 232 VKELKRKLERAKLLLPQQQLQAEADHLGKE---LQSVSAKLQAQVEE------------N 276
Query: 1713 ELAQELEELEWDMEELSWKEEELNQE-EGKLVEEKKKLAEEEEALAWQREKLSEEETKLA 1771
EL L + + EE W++EE QE E K+ E+++K+ E+EE + Q E + E+E K+
Sbjct: 277 ELWNRLNQQQ---EEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMR 333
Query: 1772 QEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKM 1831
++EE++ +++EK+ + +EKM E+E+ R++E+ +++ K+ ++ +R + + +
Sbjct: 334 RQEEMMWEKEEKIRELEEKMHEQEKI--REQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 391
Query: 1832 ILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQV 1891
I Q++ + ++++ + +++EK+ +++E + +E + ++++ + + K+ K + +
Sbjct: 392 IREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQ 451
Query: 1892 EEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLR 1951
EEK+ +++E + +++EK+ E E K+ + E AK QE+ +EKM+ EK Q KK
Sbjct: 452 EEKIREQEEMMQEQEEKMGEQEGKMCEQE---AKMQEQ--EEKMRRQEEKIREQEKKIRE 506
Query: 1952 GELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLS 2011
E I ++E+ + + +++ E++ ++ E +E + + E ++ KM + E L +++
Sbjct: 507 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Query: 2012 LEE 2014
++E
Sbjct: 567 MQE 569
Score = 138 bits (347), Expect = 9e-32
Identities = 127/484 (26%), Positives = 236/484 (48%), Gaps = 55/484 (11%)
Query: 1911 ETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQ--------GKKRLRGEL-------- 1954
+ +K Q +++L ++ E Q L +K +Q K+L GE
Sbjct: 97 DEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 156
Query: 1955 DIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEE 2014
D K L + +A +K + E L+K + + T ++EL E+ L+E
Sbjct: 157 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 216
Query: 2015 KILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLN 2074
K+ L E E+SEI E +RKL +A KL+ ++ L E L
Sbjct: 217 KLQLVES-----EKSEIQLNVKEL----------KRKLERA--KLLLPQQQLQAEADHLG 259
Query: 2075 KILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTK 2134
K L+++ KL + + R +E ++ ++ K+ +E E+ ++ +
Sbjct: 260 KELQSVSA------KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIRE 313
Query: 2135 DEKKLARKQRKLANKMRRMINKEEKMTEEESKLA----RKHSEVILDDEEEGGIEEEEVI 2190
E+K+ R++ + K +M +EE M E+E K+ + H + + ++EE EEE++
Sbjct: 314 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI- 372
Query: 2191 PFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEE 2250
++ R+ +EAK + +EK Q +++ +E +E E + E E++ EE +E
Sbjct: 373 --REQEKRQEQEAKMW-RQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQE 429
Query: 2251 REEEEEREEEEVREEEEERKEEEE--GEEKQVEKEEEEKKKKKKEKKKEE---VQEKEEV 2305
+EE+ R+EE++RE+E++ +E+EE E++++ +E+EEK +++ K E+ +QE+EE
Sbjct: 430 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEK 489
Query: 2306 FEEKEEIMSEEETESLSDEE---EEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRG 2362
+EE + E+E + EE E+EE +EE E+E E++ K+QEQ K R
Sbjct: 490 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 549
Query: 2363 RERV 2366
E++
Sbjct: 550 EEKM 553
Score = 130 bits (328), Expect = 1e-29
Identities = 88/382 (23%), Positives = 216/382 (56%), Gaps = 25/382 (6%)
Query: 1585 EKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETL 1644
++K A+ + KL E + ++ + + + +RKL +A + + Q + QAE KE L
Sbjct: 208 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ---QQLQAEADHLGKE--L 262
Query: 1645 AQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQRE 1704
KL + E+ + ++ EK+ R+EEK+ ++ K+ E + + ++ E++ +R+
Sbjct: 263 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKM-RRQ 321
Query: 1705 QNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLS 1764
+ + W+++E + EE+ W+ KEE++ + E K+ E++K+ E+EE
Sbjct: 322 EEMMWEKEEKMRRQEEMMWE------KEEKIRELEEKM-HEQEKIREQEEK--------R 366
Query: 1765 EEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRER-WINSM 1823
+EE K+ ++E+ QE K+ + +EK+ E+EE++ + E + E++ K+ ++ E+ W
Sbjct: 367 QEEEKIREQEKRQEQE-AKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEE 425
Query: 1824 EELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGM 1883
E + + + Q++ + +++K + +++EK+ +++E + +E++ + ++ + + K+
Sbjct: 426 EMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQE 485
Query: 1884 FNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLA--QEKMKLALEK 1941
+ + + EEK+ ++++ + +++EK+ E E+ + + E+ + +++EK+ +EKM+ EK
Sbjct: 486 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 545
Query: 1942 AMVQGKKRLRGELDIAKEEKAL 1963
Q +K E+ + ++E+ +
Sbjct: 546 MRRQEEKMREQEVRLRQQEEKM 567
Score = 124 bits (312), Expect = 1e-27
Identities = 108/484 (22%), Positives = 240/484 (49%), Gaps = 21/484 (4%)
Query: 1701 PQREQNLDWQEKE-LAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQ 1759
P+ EQ Q +E L +ELE + L+ ++ EL K+L E L +
Sbjct: 95 PEDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 154
Query: 1760 REKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKR-------EQLIEKKMKL 1812
+ +L Q + +K+K ++ E++ +E + L + E+L EK KL
Sbjct: 155 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 214
Query: 1813 AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK 1872
+K + + E+ N L +K E+ L +++L ++L KE + S K
Sbjct: 215 QEKLQLVESEKSEIQLNVKELKRKL----ERAKLLLPQQQLQAEADHL--GKELQSVSAK 268
Query: 1873 QLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQ 1932
QV+ ++N++ Q EEK+ +++E + +++EK+ E E+K+ + E+ + +++E + +
Sbjct: 269 LQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWE 327
Query: 1933 EKMKLALEKAMVQGKKRLRGELD--IAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETP 1990
++ K+ ++ M+ K+ EL+ + ++EK E KR EEK+R E ++
Sbjct: 328 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 387
Query: 1991 ETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQR 2050
+ + R+ + +E E EEK+ E+++ EE E+ + + + R + + ++
Sbjct: 388 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEE-EMQEQEEKMRRQEEKIREQEK 446
Query: 2051 KLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERR 2110
K+ + K+ ++ E + ++ K+ + K+ E K+ ++E KM + + + +E++
Sbjct: 447 KIREQEEKIREQEEMMQEQEEKMG---EQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKK 503
Query: 2111 LSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARK 2170
+ ++ K+ +E E+ ++ + E+K+ ++ K+ + +M +EEKM E+E +L ++
Sbjct: 504 IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQ 563
Query: 2171 HSEV 2174
++
Sbjct: 564 EEKM 567
Score = 111 bits (278), Expect = 9e-24
Identities = 93/411 (22%), Positives = 204/411 (49%), Gaps = 41/411 (9%)
Query: 1981 KETLSKGETPETSR---------QRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEI 2031
K+ ++ G PET+ ++K + QE R+L + + + RIL +++E+
Sbjct: 75 KKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVQTI----RILTCQKTEL 130
Query: 2032 AKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLT 2091
L +++ ++L +R LI + K +L + L A+ + +
Sbjct: 131 QMA-LYYSQ------HAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYI 183
Query: 2092 QEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMR 2151
+E +TK + AL ++ R +I +L K EK + ++ ++ ++L K+
Sbjct: 184 EE---LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 240
Query: 2152 R--MINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKR--KEAKRGD 2207
R ++ ++++ E L ++ V + + +EE E+ L ++ ++ ++ ++
Sbjct: 241 RAKLLLPQQQLQAEADHLGKELQSV--SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ 298
Query: 2208 KPKEKFSSQVDEVESEEHFSEEMESLL----DELEKQESLSSEEEEEREEEEEREEEEVR 2263
+ +EK Q +++ +E E ++ +++ +QE + E+EE+ E EE+ E+ +
Sbjct: 299 EREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 358
Query: 2264 EEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK-----EEVQEKEEVFEEKEEIMSEEET 2318
E+E K +EE + ++ EK +E++ K ++++K E+++E+EE+ +E+EE M E+E
Sbjct: 359 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEE 418
Query: 2319 ESLSDEE---EEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERV 2366
+ EE E+EE +EE RE+E +E++ K++EQ E++
Sbjct: 419 KMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 469
Score = 83.6 bits (205), Expect = 3e-15
Identities = 65/235 (27%), Positives = 134/235 (57%), Gaps = 16/235 (6%)
Query: 2137 KKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRR 2196
++L +++ L+ ++ R +E++ E+ +KL K +++ ++ E + +E LKR+
Sbjct: 184 EELTKERDALSLELYRNTITDEELKEKNAKLQEK-LQLVESEKSEIQLNVKE----LKRK 238
Query: 2197 WRKRKEAKRGDKPKEKFSSQVDEVESE-EHFSEEMESLLDELEKQESLSSEEEEE--REE 2253
+ K P+++ ++ D + E + S ++++ ++E E L+ ++EE+ R+E
Sbjct: 239 LERAKLLL----PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE 294
Query: 2254 EEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQ-EKEEVFEEKEEI 2312
E+ +E EE +E+EE+ E+E EK +EE +K++K +++EE+ EKEE E EE
Sbjct: 295 EKIQEREEKIQEQEEKIREQE--EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 352
Query: 2313 MSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVL 2367
M E+E +E+ +EE E+E +E+E ++ K++EQ K +R +E ++
Sbjct: 353 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK-IREQEEMM 406
Score = 50.4 bits (119), Expect = 2e-05
Identities = 40/179 (22%), Positives = 87/179 (48%), Gaps = 47/179 (26%)
Query: 1334 QEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEK 1393
+E IR +E RE+E+ ++ +M+ +E ++ ++GK M ++ +K +E+
Sbjct: 438 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGK-----------MCEQEAKMQEQ 486
Query: 1394 KTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIER 1453
+ +K +Q K ++E+K+ + + ++ ++E M E+ E+M EEK+ +QE K+
Sbjct: 487 E--EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM----- 539
Query: 1454 TPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQE 1512
+E E+++ ++EEK+ + +L +EE +QE
Sbjct: 540 -----------------------------QEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 46.2 bits (108), Expect = 5e-04
Identities = 63/354 (17%), Positives = 148/354 (41%), Gaps = 72/354 (20%)
Query: 1090 KKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKL 1149
++ +K R +K +ER+ K E + E E E W + +
Sbjct: 284 QQQEEKMWRQEEKIQEREEKIQEQEEKIREQE--------EKMRRQEEMMWEKEEKMRRQ 335
Query: 1150 SKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPP 1209
+ + +E+ I + + + +KIR++ +K+ +K++++ K++ +EAK+ +E
Sbjct: 336 EEMMWEKEEKIRE--LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 393
Query: 1210 VMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAEL 1269
E+ + ++ ++ + + KM E
Sbjct: 394 EQEEKIREQEEM--------------------------------MQEQEEKMGE------ 415
Query: 1270 VTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIR--ED 1327
WE +E + ++E K+ ++ + + ++K I QE IR E+
Sbjct: 416 ---------QEEKMWEQEEE---MQEQEEKMRRQE---EKIREQEKKIREQEEKIREQEE 460
Query: 1328 MIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEI 1387
M+Q +++ + M +E + Q++ M EE +++ +K I + + +E+
Sbjct: 461 MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEK---IREQEKKIREQEEKIREQEEM 517
Query: 1388 SKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKV 1441
+++E+K ++ Q K ++E K+ + + +M ++E M E+ + EEK+
Sbjct: 518 MQEQEEKMWE----QEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKM 567
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 167 bits (424), Expect = 1e-40
Identities = 264/1182 (22%), Positives = 510/1182 (43%), Gaps = 185/1182 (15%)
Query: 1385 KEISKKEEKKTFQKSPKQGRKAVQKERK------VGKIKR--EMTKEERDMSEEVEEMAT 1436
K +K++++ T K ++ A K R K+K +++++E +M + EE+
Sbjct: 797 KAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVK 856
Query: 1437 LEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKL 1496
+ EK + E +L +E S Q + +Q+ ET +A EE RL ++++L
Sbjct: 857 VREKQLAAENRLTEMETLQS-QLMAEKLQLQEQLQAETELCAEA--EELRARLTAKKQEL 913
Query: 1497 HQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE 1556
E + D + + EE ++ +++ + K K QQ E E LEEE S +
Sbjct: 914 -----------EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 1557 KEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEE-KLAQEERQLAQEERK 1615
+ ++VT E A+ K+ +EE+ + +++ KLA+E++ L E +
Sbjct: 963 QLEKVTTE-------------------AKLKKLEEEQIILEDQNCKLAKEKKLL---EDR 1000
Query: 1616 LAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVARE 1675
+A+ +T+++ E +++ K K E + E+ + EK Q+ +K +K E + +
Sbjct: 1001 IAEFTTNLTEEE-EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 1676 -EEKLAKKGGKLAEVKNILAQKVEELP---QREQNLDWQEKELAQELEELEWDMEELSWK 1731
+++A+ ++AE+K LA+K EEL R + Q+ +++ ELE + EL
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 1732 EEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKM 1791
E K ++K+ L EE EAL + +L + A ++EL + ++++ K+ +
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEAL---KTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 1792 PEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKE 1851
EE + Q+ E + K +Q E +E+ + K NL + K+ L E+
Sbjct: 1177 EEEAK---THEAQIQEMRQKHSQAVEELAEQLEQTKR------VKANLEKAKQTLENERG 1227
Query: 1852 KLAQRKENLLYNKERLTHSKK----QLVQVKNKLGMFNKILAQVEEKLTQ---EKETVI- 1903
+LA + LL K H +K QL +++ K ++ ++ +K+T+ E + V
Sbjct: 1228 ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG 1287
Query: 1904 ---KKKEKLAETEKKLVQVEDSLAKKQEKLAQE---KMKLALEKAMVQGKKRLRGELDIA 1957
+ K ++ K +E L QE L +E K+ L+ + V+ +K E
Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE 1347
Query: 1958 KEEKALNLE------------MKRLAEE-----------KMRLVEGKETLSKGETPETSR 1994
+EE NLE MK+ E+ K +L + E LS+ + +
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA 1407
Query: 1995 QRKM----TQVEQELFERKLSLE---------EKILLHEDRILAMEESEIAKGKLEFTRG 2041
K+ T+++QEL + + L+ EK D++LA E++ AK E R
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRA 1467
Query: 2042 QRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKA-LQKLTRDERKLTQEEIKMTKM 2100
+ + + K +R L + E E +LNK + ++ L + + + ++ K
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQ-KAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKS 1526
Query: 2101 KRAL--FVKERRLSIEQSKLDIKEWDFSEKRSEL------TKDEKKLARKQRKLANKMRR 2152
KRAL V+E + +E+ + +++ + ++ R E+ + E+ L + + K ++
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ 1586
Query: 2153 MINKEEKM---TEEESK------LARKHSEVILDDEE----EGGIEEEEVIPFLKRRWRK 2199
++ + +M E+E K ARK E+ L D E +E I L++ +
Sbjct: 1587 LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646
Query: 2200 RKEAKR----GDKPKEKFSSQVDEVESE-EHFSEEMESLLDELEKQESLSSEEEEEREE- 2253
K+ R +E+ +Q E E + + EM L +EL E + ++ER+E
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706
Query: 2254 ---------------EEEREEEEVREEEEERKEEEEGE--------------------EK 2278
EE+R E + EE EEE+G +
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL 1766
Query: 2279 QVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVD 2338
+E+ +K + +++ + + +E + +E E + + S++ E + LEE++D
Sbjct: 1767 NLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT--ALEAKIAQLEEQLD 1824
Query: 2339 REKEILKKEKQFKLQEQRRKSLRGRERVLSI---LRGVPHGKGRAIRLGVLKSPLKKLMS 2395
E KE+Q ++ RR + ++ +L + R K +A + LK+ +
Sbjct: 1825 NE----TKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLE 1880
Query: 2396 TALEMKEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKER 2437
A E ++ + Q ED T + R+ +K R
Sbjct: 1881 EAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 145 bits (367), Expect = 4e-34
Identities = 235/1136 (20%), Positives = 486/1136 (42%), Gaps = 129/1136 (11%)
Query: 1262 SENLNAELVTFAQEMLVDRHPSWELFQ---EICP----------LLKKESKVLLEDLDWD 1308
+EN E+ T +++ ++ E Q E+C K+E + + DL+
Sbjct: 864 AENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEAR 923
Query: 1309 VVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILK 1368
V E++ +Q A ++ M Q+ I+ E EEE A++K + L T+ LK
Sbjct: 924 VEEEEERCQHLQ--AEKKKM-----QQNIQELEEQLEEEESARQKLQ--LEKVTTEAKLK 974
Query: 1369 K-GKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDM 1427
K ++ I LE N + KE KK + + + +E + K ++ + M
Sbjct: 975 KLEEEQIILEDQNCKLAKE------KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028
Query: 1428 SEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEK 1487
++EE EEK ++ K R D D+ ++ + E +
Sbjct: 1029 ITDLEERLRREEKQRQELEKT----RRKLEGDSTDLSDQIAELQAQIA--------ELKM 1076
Query: 1488 RLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLE 1547
+L ++EE+L A ++ EEE Q++ LK + E Q + +E
Sbjct: 1077 QLAKKEEELQAALARV--EEEAAQKNMALK------------KIRELESQISELQEDLES 1122
Query: 1548 EEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAE--KKRAQEERKLAQE-EEKLAQ 1604
E SR EK+++ E+ + + A+ E KR QE L + EE+
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182
Query: 1605 EERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKK 1664
E Q+ + +K +QA ++ + + + + + ++TL +L+ E + L Q +
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 1665 LAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNL-------DWQEKELAQE 1717
K +KV + ++L K + V+ LA KV +L N+ D + +L ++
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 1718 LEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELL 1777
LE +++ +E N+++ L + K++ +E+ + RE+L EEE E+ +
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF---REQLEEEEEAKHNLEKQI 1359
Query: 1778 IQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKK 1837
++A K+KM E+ +G +E ++ +K ++ + + + + K+ Y K
Sbjct: 1360 ATLHAQVADMKKKM---EDSVG-----CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK- 1410
Query: 1838 NLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQ 1897
L + K +L Q ++LL + L H ++ ++ K F+++LA+ + +
Sbjct: 1411 --------LEKTKTRLQQELDDLLVD---LDHQRQSACNLEKKQKKFDQLLAEEKTISAK 1459
Query: 1898 EKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQ-----EKMKLALEKAMVQGKKRLRG 1952
E + + + E E K + + +L + E+ A+ ++ + +E M +
Sbjct: 1460 YAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS 1519
Query: 1953 ELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETP----ETSRQRKMTQVEQELFER 2008
++ K ++AL +++ E K +L E ++ L E E + Q Q E++L R
Sbjct: 1520 VHELEKSKRALEQQVE---EMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGR 1576
Query: 2009 KLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQR-IFVQGQRKLAKASRKLIKKRESLS 2067
EEK ++ ME +LE R QR + V ++KL + L +S +
Sbjct: 1577 DEQSEEKKKQLVRQVREME------AELEDERKQRSMAVAARKKLEMDLKDLEAHIDSAN 1630
Query: 2068 KEPAKLNKILKALQKLTRD------ERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIK 2121
K + K L+ LQ +D + + ++EEI + +K + Q + ++
Sbjct: 1631 KNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELA 1690
Query: 2122 EWDFSEKRSELTKDE--KKLARKQRK--LANKMRRMINKEEKMTEEESKLARKHSEVILD 2177
+ ++++++ +DE ++A K LA + +R + EEE + + ++E+I D
Sbjct: 1691 AAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIND 1750
Query: 2178 DEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDEL 2237
++ ++ +++ L +R A++ + +++ Q E++ + +EME +
Sbjct: 1751 RLKKANLQIDQINTDLNL---ERSHAQKNENARQQLERQNKELKVK---LQEMEGTVKSK 1804
Query: 2238 EK------QESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKK 2291
K + ++ EE+ E +ER+ + E+K ++ + E+ E+ K +
Sbjct: 1805 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ 1864
Query: 2292 KEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKE 2347
+K +++ + EE EE + E E++ + ++RE LK +
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 167 bits (423), Expect = 1e-40
Identities = 247/1138 (21%), Positives = 508/1138 (44%), Gaps = 169/1138 (14%)
Query: 1315 KPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDML---GLEETQVILKKGK 1371
K + +E ++RE Q+V R E + +E Q ++L G+E+ V+ K+
Sbjct: 176 KSKYDEERSLRE----AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELV 231
Query: 1372 KVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEV 1431
+V L N+T+ +E +E +K + K + E + +++ E+ K ++++ V
Sbjct: 232 QVQTLMD-NMTLERE---RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287
Query: 1432 EEMATLEEKV--VKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRL 1489
+E+ L+ V + Q+ + + QD+ K ++ H E S K+ + L
Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKL----EEKHNEESVS----KKNIQATL 339
Query: 1490 LQEEEKLHQAGEKLSPEEEMLQE---DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTL 1546
Q++ Q +LS E L + K E +++ E + ++K Q K E +
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFK--- 396
Query: 1547 EEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEE 1606
++ ++ EEKEQ + Q I + H K + ER+L + +L +E+
Sbjct: 397 --QLQQQREEKEQHGLQLQSEINQLHS-------------KLLETERQLGEAHGRL-KEQ 440
Query: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA 1666
RQL+ E K+ ++++A + K ++ EE L EK++ E Q K
Sbjct: 441 RQLSSE---------KLMDKEQQVADLQLKLSRLEEQLK---EKVTNSTELQHQLDKTKQ 488
Query: 1667 KKWEKVAREEEKLAKKGGKLAEVKNILAQKVEEL---PQREQNLDWQEKELAQELEELEW 1723
+ E+ A ++ AK L E +N L Q + ++ Q+ QNL+ ++ + + LE
Sbjct: 489 QHQEQQALQQSTTAK----LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK 544
Query: 1724 DMEELSWKEEELNQEEGKL--VEEKKKLAEEEEALAWQREKLSEEETKLAQEE--ELLIQ 1779
+ E+L K + E L ++EK +E+ ++ K E K AQE + + +
Sbjct: 545 EREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE 604
Query: 1780 EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNL 1839
+K L ++++ E + QL E K K++Q ++ K +++L +
Sbjct: 605 QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQL------DIQIKAKTELLLSAEAAK 658
Query: 1840 AQEKKNLAQEKEKLAQRKENLLYNKER-LTHSKKQLVQVKNKLGMFNKILAQVEEKLTQE 1898
++ +L + +N L +K++ L QL QV KL + +Q+E L +
Sbjct: 659 TAQRADLQNHLDTA----QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714
Query: 1899 KETVIKKKEKLAETEKKLVQVE-DSLAKK-------QEKLAQEKMKLALEKAMVQGKKRL 1950
KE + ++K E E ++ ++E DSL K Q+ Q ++ LE + K+L
Sbjct: 715 KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774
Query: 1951 RGE--------LDIAKEEKALNLEMKRLA---EEKMRLVEGKETLSKGETPETSRQRKMT 1999
E LD+ K+ +AL ++L EEK L + ETLS+ ET + +
Sbjct: 775 EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ-ET-KIQHEELNN 832
Query: 2000 QVEQELFE-RKLSLEEKILLHE-----DRILAMEESEIAKGKLEFTR----GQRIFVQGQ 2049
+++ + E +K+ +E++ L+ E D++ + +S + K EF + G+ + +
Sbjct: 833 RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS-LKNSKSEFEKENQKGKAAILDLE 891
Query: 2050 RKLAKASRKLIKKRESLSKEPAKLNK----------------------ILKALQKLTRDE 2087
+ + +L + E+ KE +L K +++A L ++E
Sbjct: 892 KTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNE 951
Query: 2088 RKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRS----ELTKDEKKLARKQ 2143
++ Q + + ++K++ K++++ Q +L I +E + +LT+ ++LA ++
Sbjct: 952 KEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEK 1011
Query: 2144 RKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEA 2203
K++ +E + +S + SE++ ++ +EE+ +
Sbjct: 1012 EKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA------------ 1059
Query: 2204 KRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEER-------EEEEE 2256
+E S +++ ++ +E+++ LE+ + ++ +ER ++E+
Sbjct: 1060 ------QEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS 1113
Query: 2257 REEEEVREEEEERKEEEE---GEEKQVEKEEEEKKKKKKEKKKEEVQEKEE---VFEEKE 2310
+E+E+ E+ + E EE +EK++ K EE K K E KE K+ + ++K
Sbjct: 1114 LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL 1173
Query: 2311 EIMSEEETESLSDEEEEEESCSLEEEVDREKEILKK---EKQFKLQEQRRKSLRGRER 2365
E+ + ++ + E+E+ L+++V +E+E LKK EK+ KL + ++ G ++
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKK 1231
Score = 105 bits (263), Expect = 5e-22
Identities = 211/1065 (19%), Positives = 440/1065 (41%), Gaps = 158/1065 (14%)
Query: 975 LSLMAEIG-IHSRT--SLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVE 1031
L L +EI +HS+ + QL + +E Q+Q+ E+ +D + DLQ+ +++E
Sbjct: 410 LQLQSEINQLHSKLLETERQLGEAHGRLKE-QRQLSSEKLMDK--EQQVADLQLKLSRLE 466
Query: 1032 QRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKK 1091
++L E +T S +EL+ L + + A++ S A +++
Sbjct: 467 EQLKEKVTNS---------------TELQHQLDKTKQQHQEQQALQQST-----TAKLRE 506
Query: 1092 HSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSK 1151
+ L++ ++D K + E L +S + +E E +Y++ + +
Sbjct: 507 AQNDLEQVLRQIGDKDQKIQNLEA--LLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 1152 DVDSQEKDISKDHIALT--LKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPP 1209
+ + + + LT LK + + + Q ++K + + +V++ ET+
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
Query: 1210 VMEQPVTKKVKIQGRGASGISGRR----STAGDGSSWRDDLCRLMALRISGSQTKMSENL 1265
+ + + + + I + S ++ R DL + + Q K E L
Sbjct: 625 ELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE-L 683
Query: 1266 NAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLL------EDLDWDVVPPEKKPIFI 1319
N ++ T ++ E ++ LK+ + L E+L+ + E + +
Sbjct: 684 N-KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
Query: 1320 QEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPG 1379
+ A +E +Q + Q+ + ++ R E +++ + + T++ L+K + +
Sbjct: 743 K--ASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL----- 795
Query: 1380 NVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEE 1439
++ ++++K+EE+K K Q + + +E K+ + +++ ++ T +
Sbjct: 796 -ESIKQKLTKQEEEKQILK---QDFETLSQETKI---------QHEELNNRIQTTVTELQ 842
Query: 1440 KVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQA 1499
KV K E + +M E + K D K E K ++ + +L E+ +
Sbjct: 843 KV-KMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE----NQKGKAAILDLEKTCKEL 897
Query: 1500 GEKLSPE-EEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKE 1558
+L + E L+E K+LK KS E++ + ++ LE +E + +
Sbjct: 898 KHQLQVQMENTLKEQKELK--------------KSLEKEKEASHQLKLELNSMQE-QLIQ 942
Query: 1559 QQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQ 1618
Q T +Q +E+ I+ + +E+K+ Q E + + + Q+ + +++L Q
Sbjct: 943 AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
Query: 1619 AYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEK 1678
A ++ + +++ + + + +ET Q +L R+ L EK++ +E
Sbjct: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 1679 LAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQE 1738
L ++ ++ + EQ+ +E++L + + L+ +E S KE+EL E
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 1739 EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERL 1798
+ KL E EE K QE+E + + E+L HK + +E L
Sbjct: 1123 KSKLAE--------------------IEEIKCRQEKE-ITKLNEELKSHKLESIKEITNL 1161
Query: 1799 GRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKE 1858
++ LI++K++L K + ++E+ +N+ IL K + +E+E+L
Sbjct: 1162 KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL---------KDQVKKEEEEL----- 1207
Query: 1859 NLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQ 1918
KK+ ++ + KL +EKE +KK E E E KL
Sbjct: 1208 ------------KKEFIEKEAKL-----------HSEIKEKEVGMKKHE---ENEAKLTM 1241
Query: 1919 VEDSLAK-----KQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEE 1973
+L + K+E + ++ LEK LRGE+ + + N + +R E
Sbjct: 1242 QITALNENLGTVKKEWQSSQRRVSELEKQ----TDDLRGEIAVLEATVQNNQDERRALLE 1297
Query: 1974 KMRLVEGKETLSKGETPETSRQRKM---TQVEQELFERKLSLEEK 2015
R ++G+ + K +T QRK+ T QEL SL+ K
Sbjct: 1298 --RCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
Score = 45.1 bits (105), Expect = 0.001
Identities = 119/599 (19%), Positives = 231/599 (38%), Gaps = 79/599 (13%)
Query: 995 KQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENLTLSHRDEKPAFSLDVS 1054
KQ+ Q+ I E L++ + T+LQ + + E + E T+ + K + SL S
Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872
Query: 1055 MPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKTKERDSKQMSTE 1114
K + K + E K K Q + Q QK L+ + ++ S Q+ E
Sbjct: 873 KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE 932
Query: 1115 PGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQK 1174
++++ ++ E Q + + +K S + ++ + + + + + + +
Sbjct: 933 LNSMQEQLIQAQNTLKQNEKE-EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTE 991
Query: 1175 IRDKRDKKAT--AQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGR 1232
+ +K ++ T AQ+L + +K V++ K + + S GR
Sbjct: 992 LENKLQQQLTQAAQELAAEKEKIS-------------VLQNNYEKSQETFKQLQSDFYGR 1038
Query: 1233 RS----TAGDGSSWRDDLCRLMALRIS-----GSQTKMSENLNAELVTFAQEMLVDRHPS 1283
S T D S + L IS G+Q K+ + L T Q D
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ----DSAKK 1094
Query: 1284 WELFQEICPLLK--KESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKE 1341
+ QE C L+ ++ K L E ++V + K I+E R++ KE
Sbjct: 1095 EQQLQERCKALQDIQKEKSLKEK---ELVNEKSKLAEIEEIKCRQE------------KE 1139
Query: 1342 VMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPK 1401
+ EE K + ++ K K + ++ GK S K + +++ +
Sbjct: 1140 ITKLNEELKSHKLESI-----KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQ 1194
Query: 1402 QGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWK 1461
+ V+KE + ++K+E ++E + E++E +K + E KL M
Sbjct: 1195 ILKDQVKKEEE--ELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM----------- 1241
Query: 1462 KAWDEWKQVHGETRKSWKAWK---EEWEKRL--LQEEEKLHQAGEKLSPEEEMLQEDKKL 1516
+ G +K W++ + E EK+ L+ E + +A + + +E ++ L
Sbjct: 1242 -QITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCL 1300
Query: 1517 KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWA 1575
K E + L +K E Q K + +E+ RE + + + T+ KWA
Sbjct: 1301 KGEGEIE----KLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQAL-----NRKWA 1350
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 166 bits (420), Expect = 3e-40
Identities = 278/1410 (19%), Positives = 598/1410 (42%), Gaps = 185/1410 (13%)
Query: 1128 PIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQK 1187
P+ +E Q++S+ +K + V+ ++S D L R + + K+ + + +
Sbjct: 310 PVSFDETLTALQFASTAKYMKNTPYVN----EVSTDEALLKRYRKEIMDLKKQLEEVSLE 365
Query: 1188 LKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDDLC 1247
+ + +K + A+++ E+ K+Q ++ R + + +L
Sbjct: 366 TRAQAMEKDQLAQLLEEKDLLQ----------KVQNEKIENLT-RMLVTSSSLTLQQELK 414
Query: 1248 RLMALRIS---GSQTKMSENLNAELVTFAQEMLVDRHP-SWELFQEICPLLKKESKVL-- 1301
R++ G KM + A+ + H S L +EI + ES V
Sbjct: 415 AKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSN 474
Query: 1302 ----LEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDM 1357
L +++W+ P K + + + ++ ++ E + E+E+ + K ++
Sbjct: 475 TLDTLSEIEWN---PATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEK 531
Query: 1358 LGLEETQVILKKGKK----------------VIFLEPGNVTMGKEISKKEEKKTFQKSPK 1401
L+E + + +K KK V E N + E+S K E ++
Sbjct: 532 NDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQI 591
Query: 1402 QGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVV-----KQEGKLVMIERTPS 1456
+ + +K+ IK +++ + + + TL + K+E + E
Sbjct: 592 KKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLEL 651
Query: 1457 WQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKL 1516
+ K+ +KQ+ + + +++ E +K + E++L A +++ ++ + K
Sbjct: 652 KEKMKELATTYKQMENDIQL-YQSQLEAKKKMQVDLEKELQSAFNEITKLTSLI-DGKVP 709
Query: 1517 KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWAR 1576
K E ++ KE + EE L EEV E K E+ + + K
Sbjct: 710 KDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEE 769
Query: 1577 IHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKIT-QDDREMAQAEG 1635
+H + +K ++ K ++ + L EE +++ Q+ K T Q+ +
Sbjct: 770 LHIITSEKDKLFSEVVHKESRVQGLL--EEIGKTKDDLATTQSNYKSTDQEFQNFKTLHM 827
Query: 1636 KFAQKEETLAQRGEKLSQEAEKLAQKRKK----LAKKWEKVAREEEKLAKKGGKLAEVKN 1691
F QK + + + E+++QE L+++ +K L +++ + ++L +K ++ E N
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLN 887
Query: 1692 ILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAE 1751
+ Q E+L R+ L E+E E+L+ +EE+ L +EK L +
Sbjct: 888 EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK-----------TLTQEKDDLKQ 936
Query: 1752 EEEALAWQREKLSEE-----------ETKLAQEEELLIQEKEKLAQHKEKMPEE------ 1794
+E+L +R++L + + +L E L Q +E + K K+ EE
Sbjct: 937 LQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLH 996
Query: 1795 -EERLGRKREQLIEKKMKLAQKRERWINSMEELT---KNKMILYQKKNLAQEKKNLAQEK 1850
EE G +++ +K + + +K++ + + LT K+ I+ Q++ + +L QEK
Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIF----SLIQEK 1052
Query: 1851 EKLAQRKENLLYNKERLTHSKKQLVQV----KNKLGMFNKILAQVEEKLTQEKETVIKKK 1906
+L Q E+++ KE+L K+ +++ + +L + L + +E + QEK IKK+
Sbjct: 1053 NELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE 1112
Query: 1907 EKLAETEKKLVQVEDSLAKKQEKLAQEKMKLA-LEKAMVQGKKRLRGELDIAKEEKALNL 1965
+L+ T +L +VE+ L +K ++L +++ +L +++ M + +K++ ++ E K L
Sbjct: 1113 GELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKEL 1172
Query: 1966 EMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILA 2025
++ + E++ L + K + E +++RK+ + Q+ FE + + +
Sbjct: 1173 TLEHMETERLELAQ-KLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGL 1231
Query: 2026 MEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTR 2085
+ E+ + Q + +R +++ + ++I ++ L K KL
Sbjct: 1232 QTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD-LEKSHTKL------------ 1278
Query: 2086 DERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRK 2145
QEEI + ++ L + +S Q ++ E + ++S TKD LAR + +
Sbjct: 1279 ------QEEIPVLHEEQELLPNVKEVSETQETMN--ELELLTEQST-TKDSTTLARIEME 1329
Query: 2146 LANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKR 2205
R +N++ + ++EE K K + + +E ++ +++ ++ K +E++
Sbjct: 1330 -----RLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQS 1384
Query: 2206 GDKP----KEKFSSQVDEVESEEHFSEEMESLLD-ELEK-------QESLSSEEEEEREE 2253
+ KEK + V E F + +LL E+E QES + +E+
Sbjct: 1385 KQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1444
Query: 2254 EEEREEEEVREEEEERKEEEEGE--EKQVEKEEEEKKKKKKEKKKEE-VQEKEEVFEEKE 2310
++ + +EV + E ++ +E E K +E EEE K K++EE + E EKE
Sbjct: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE 1504
Query: 2311 EIMS--EEETESLSDE--------EEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSL 2360
+S +++ E+++D+ E+EE ++ +++ +E + + KQFK
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNI-KQISEVQEKVNELKQFK--------- 1554
Query: 2361 RGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEK--------- 2411
H K + L ++S + +L + E +E+ + + EK
Sbjct: 1555 -------------EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA 1601
Query: 2412 -QISWEDKKATVVEIPRKFLGTMDKEREVM 2440
QI + K EI K + +KE + +
Sbjct: 1602 LQIERDQLKENTKEIVAKMKESQEKEYQFL 1631
Score = 161 bits (408), Expect = 8e-39
Identities = 365/1856 (19%), Positives = 786/1856 (42%), Gaps = 294/1856 (15%)
Query: 1008 GEEPLDHLLGM----RATDLQILSTQVEQRLNENLTLSHRDEKPAFSLDVSMPSELKSSL 1063
G+ P D L + + TDLQ ++ + + EN L R+E S S+PSE++ L
Sbjct: 706 GKVPKDLLCNLELEGKITDLQ---KELNKEVEENEAL--REEVILLSELKSLPSEVER-L 759
Query: 1064 KPPTVSEESEVAIKPSKGQRRGQAGVKKHS--QKWLRGLKKTKERDSKQMSTEPGLLEDE 1121
+ + E+ I S+ + V K S Q L + KTK+ + S ++
Sbjct: 760 RKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF 819
Query: 1122 SGTEAAPIEMEEAS---VYSQWSSSTSVIKLSKDVDSQEKDIS--KDHIALTLKRLQ-KI 1175
+ ++ E+ + + ++ LSK+ + + K ++ + LQ K
Sbjct: 820 QNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKT 879
Query: 1176 RDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRST 1235
R+ +++ ++LK++ + + + + E T +T+K++ ++ +
Sbjct: 880 REVQERLNEMEQLKEQLENRDSTLQTVEREKTL------ITEKLQQTLEEVKTLTQEK-- 931
Query: 1236 AGDGSSWRDDLCRLM-ALRISGSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLL 1294
DDL +L +L+I Q K + + QE L + S + QE L
Sbjct: 932 --------DDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL 983
Query: 1295 K-KESKVLLEDLDWDVVPPEKKPIFIQEGA---IREDMIQGVTQEV---IRHKEVMPREE 1347
K K S+ + +L + E K F Q+ ++D+ TQ + ++ E++ ++
Sbjct: 984 KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQR 1043
Query: 1348 E-----QAQKKARDMLGLEETQVILKKGKKVIFLEPGNVT---------MGKEISKKEEK 1393
+ Q + + + ML E+ + K+ K E +T +G E+ K++E
Sbjct: 1044 KIFSLIQEKNELQQML---ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI 1100
Query: 1394 KTFQKS---PKQGR------KAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQ 1444
+K+ K+G + + E K+ + +++ ++++ + EEM+ +++K+ +
Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Query: 1445 EG------------------KLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKE--- 1483
E +L + ++ + K+ + ++V E +KS++ ++
Sbjct: 1161 ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLR 1220
Query: 1484 ----EWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQV--WENMLSSKSKEQQ 1537
E E LQ +E+L A L +E + E ++ E+ Q+ +++ S +K Q+
Sbjct: 1221 GYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE 1280
Query: 1538 -----YKDEEEVTLEEEVSREGEE-KEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQE 1591
++++E + +EVS E E ++ EQ ++ ARI +R R +K +
Sbjct: 1281 EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQE- 1339
Query: 1592 ERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKL 1651
+QEE K +ER + K + +++ D + ETLA+ E
Sbjct: 1340 ----SQEEIKSLTKER----DNLKTIKEALEVKHDQLK--------EHIRETLAKIQESQ 1383
Query: 1652 SQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQE 1711
S++ + L K K + K+ E E+ K L ++ ++ L +R Q +
Sbjct: 1384 SKQEQSLNMKEKD--NETTKIVSEMEQFKPKDSALLRIEI----EMLGLSKRLQESHDEM 1437
Query: 1712 KELAQELEELEWDMEELSWKEEELNQEEGKLV------EEKKKLA-----EEEEALAWQR 1760
K +A+E ++L+ E L + ++L + ++V EE+ K+A E+EE + R
Sbjct: 1438 KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR 1497
Query: 1761 EKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKM----KLAQKR 1816
LSE+ET+++ ++ L +KL +++ E+EE+ K+ +++K+ + + R
Sbjct: 1498 VNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHR 1557
Query: 1817 ERWINSMEELTKNKMILYQKKNLAQEK-KNLAQEKEKLAQRKENLLYNKERLTHSKKQLV 1875
+ ++++ + + L + +QE+ + + +EKE++ + +E L +++L + K++V
Sbjct: 1558 KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV 1617
Query: 1876 QVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAK-KQEKLAQEK 1934
+ K +QEKE K + ET++K+ ++E + + +KL E
Sbjct: 1618 ---------------AKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662
Query: 1935 MK---LALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPE 1991
++ + L + + + + +R + KE L + L E+ +L KE L + T +
Sbjct: 1663 IETENIRLTQILHENLEEMRS---VTKERDDLRSVEETLKVERDQL---KENLRETITRD 1716
Query: 1992 TSRQRKMTQVEQELFERKLSLEEK--ILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQ 2049
+Q ++ V L E + ++++ I+ + ++ + ++ + + Q + +Q +
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN-DALKAQDLKIQEE 1775
Query: 2050 RKLAKASRK-----LIKKRESLSKEPAKLNKILKALQ----KLTRDERKLTQEEIKMTKM 2100
++A K + K R +S++ KL+ + K L+ KL ++L E ++ +
Sbjct: 1776 LRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITL 1835
Query: 2101 KRALFVKERRLS-IEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEK 2159
K+ + ++++S +EQ K IK D S S+L + LA+K + +M+ ++ + +
Sbjct: 1836 KKDVNETQKKVSEMEQLKKQIK--DQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1893
Query: 2160 M--TEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS-- 2215
+ EE KL R + L + + +E ++ + + ++ KE DK +EK S
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETV--DKLREKISEKT 1951
Query: 2216 -QVDEVESE-EHFSEEMESLLDELEKQE--SLSSEEEEEREEEEEREEEEVREEEE---- 2267
Q+ +++ + + +E++ + EL+K+E L +E+ ++ E E+++++ E
Sbjct: 1952 IQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNL 2011
Query: 2268 ------------ERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE-----KEEVFEEKE 2310
+K E EE ++ +E ++ ++ KE K E + +E + +++
Sbjct: 2012 SMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQ 2071
Query: 2311 EIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQF----------------KLQE 2354
+ E LSD ++ SL E+ R KE+LK+ + +++
Sbjct: 2072 NHQVKPEKRLLSDGQQHLTE-SLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEF 2130
Query: 2355 QRRKSLRGRERVLSILRGVPH-------GKGRAIRLGVLKSPLKKLMSTALEMKEKTPVP 2407
Q+ S+R + + H + ++ + LK ++S ++K
Sbjct: 2131 QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIK------ 2184
Query: 2408 VPEKQISWEDKKATVVEIPRKFLGTMDKEREVMGKYE------PIPPHVLGTVLESQAQD 2461
E++ ++ + F+ ++K++E++ K + +P L + +Q D
Sbjct: 2185 --------EEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMD 2236
Query: 2462 LKTPFMSHILRRTVEAEELQHKPLGAWWKWFLQHPPLMGQTEVQLPLSQIPAKEQHADVS 2521
L + IL+ E+E P + +TE Q LS Q +
Sbjct: 2237 L---HIEEILKDFSESE----------------FPSI--KTEFQQVLSNRKEMTQFLE-- 2273
Query: 2522 LSDVEWI--RHVLERMEAGEQLSRDGFHRLCQLLKDLASKGNLEWLHLAKHEAIVYRHRQ 2579
EW+ R +E+++ G Q D R+CQ+ ++ + +E+ + R
Sbjct: 2274 ----EWLNTRFDIEKLKNGIQKEND---RICQVNNFFNNR-----IIAIMNESTEFEERS 2321
Query: 2580 ALESQDTR--ISSRQSMSPKYLKVIPPIKAKEKESWPKPLAVPTQKSPLATKRIPDPRAK 2637
A S++ + S + + K K +K K+P T R +
Sbjct: 2322 ATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTE 2381
Query: 2638 NWHLLGEPYRSERAQQISIAHKEMEMQYFYPATRDIFPSAHASVEKQTLALMFQKD 2693
L + + K ++MQ T DI A V + L K+
Sbjct: 2382 KIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKE 2437
Score = 131 bits (329), Expect = 1e-29
Identities = 306/1611 (18%), Positives = 678/1611 (42%), Gaps = 229/1611 (14%)
Query: 966 KDERVRIKTLSLMAEIGIHSRTSLLQLTQKQ-------ETFREMQQQMIGEEPLDHLLGM 1018
K E +T +AE+ + QL +KQ E EMQ+++ E L + L
Sbjct: 1110 KKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKN 1169
Query: 1019 RATDLQILST---QVEQRLNENLT-------------------LSHRDEKPAFSLDVSMP 1056
+ L+ + T ++ Q+LNEN + RD + ++
Sbjct: 1170 KELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEAT 1229
Query: 1057 ----------------------SELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQ 1094
EL+ S+ T + ++ S + + + V Q
Sbjct: 1230 GLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQ 1289
Query: 1095 KWLRGLKKTKERDSKQMSTEPGLLEDES----GTEAAPIEMEEASVYSQWSSSTSVIK-L 1149
+ L +K+ E +++ E LL ++S T A IEME + ++ S IK L
Sbjct: 1290 ELLPNVKEVSE--TQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 1150 SKDVDS---------QEKDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAK 1200
+K+ D+ + D K+HI TL ++Q+ + K++ Q L K +K + K
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE-----QSLNMK-EKDNETTK 1401
Query: 1201 VINE-ETTPPVMEQPVTKKVKIQGRGASGISGRRSTAGDG----SSWRDDLCRLMALRIS 1255
+++E E P + +++I+ G+S R + D + +DDL RL + +
Sbjct: 1402 IVSEMEQFKP--KDSALLRIEIE---MLGLSKRLQESHDEMKSVAKEKDDLQRLQEV-LQ 1455
Query: 1256 GSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKK 1315
++ EN+ + +V +H E ++ KE + + +L ++ E +
Sbjct: 1456 SESDQLKENI---------KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506
Query: 1316 PIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIF 1375
IQ+ ++ + ++ Q K +++ EE I
Sbjct: 1507 ISTIQK------QLEAI--------------NDKLQNKIQEIYEKEEQFNI--------- 1537
Query: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMA 1435
K+IS+ +EK K K+ RKA K+ + I+ +M + + E EE+
Sbjct: 1538 ---------KQISEVQEKVNELKQFKEHRKA--KDSALQSIESKMLELTNRLQESQEEIQ 1586
Query: 1436 TL--EEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
+ E++ +K+ + + IER ++ K+ + K+ + + K + + E
Sbjct: 1587 IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEI 1646
Query: 1494 EKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSRE 1553
E L + E E ++ + + + E M S + + EE TL+ E +
Sbjct: 1647 EHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE-TLKVERDQL 1705
Query: 1554 GEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEE-EKLAQEERQLAQE 1612
E + +T + QEE K +H K ++ + R + E+ +++ ++ L
Sbjct: 1706 KENLRETITRDLEK-QEELKIVHMHLKE---HQETIDKLRGIVSEKTNEISNMQKDLEHS 1761
Query: 1613 ERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKV 1672
L +KI + E+ A +++ET+ + +S++ +KL+ +K L K+
Sbjct: 1762 NDALKAQDLKIQE---ELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL 1818
Query: 1673 AREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKE 1732
+ ++L +L +K + + +++ + EQ L Q K+ + L +LE + L+ K
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQ-LKKQIKDQSLTLSKLEIENLNLAQKL 1877
Query: 1733 EELNQEEGKLVEEKKKLAEEEEALAWQREKLSE--EETKLAQEEELLIQEKEKLA----- 1785
E +E +++E+ L EE L +R++L E +ETK +L IQ++ K A
Sbjct: 1878 HENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETK---ARDLEIQQELKTARMLSK 1934
Query: 1786 QHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKN 1845
+HKE + + E++ K Q+ + + L + ++ ++EL K ++ L + K
Sbjct: 1935 EHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHK 1994
Query: 1846 LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKK 1905
E E+L ++ E + + + QL + ++ +I+A+ ++L + KE++ +
Sbjct: 1995 KINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME 2054
Query: 1906 KEKLAETEKKLV--QVEDSLAKKQEKL---AQEKMKLALEKAMVQGKKRLRGELDIAKEE 1960
+++ T ++++ ++ K +++L Q+ + +L + + K+ L+ ++
Sbjct: 2055 RDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY 2114
Query: 1961 KALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF--ERKLSLE----- 2013
+ LN RL+ + + +E ++ LS S T+ ++LF ++ S+E
Sbjct: 2115 ECLN----RLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIM 2170
Query: 2014 ---EKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKE- 2069
+ +L + +I + I K +++F V+ Q++L + L + + S+E
Sbjct: 2171 KKLKYVLSYVTKIKEEQHESINKFEMDFIDE----VEKQKELLIKIQHLQQDCDVPSREL 2226
Query: 2070 -PAKLNKILKA-LQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSE 2127
KLN+ + ++++ +D + IK T+ ++ L ++ + L+ + +D +
Sbjct: 2227 RDLKLNQNMDLHIEEILKDFSESEFPSIK-TEFQQVLSNRKEMTQFLEEWLNTR-FDIEK 2284
Query: 2128 KRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEE 2187
++ + K+ ++ + N++ ++N+ + E + +++ E E
Sbjct: 2285 LKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISK---------------EWE 2329
Query: 2188 EVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDEL--EKQESLSS 2245
+ + LK + K + + K +QV+ ++++ + + S +L EK L +
Sbjct: 2330 QDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPT-TQDNKNPHVTSRATQLTTEKIRELEN 2388
Query: 2246 EEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE---- 2301
E +E +E + ++ ++E + + Q + E K +K ++ + +Q+
Sbjct: 2389 SLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVAL 2448
Query: 2302 -----KEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQR 2356
KEE+ + K +++ + + + +E E+E + + V+ +KE+++ L+E
Sbjct: 2449 GAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIR-----LLRENL 2503
Query: 2357 RKSLRGRERVLSILRGVPHGKGRAIRLG------------VLKSPLKKLMSTALEMKEKT 2404
R+S + ++ + P + + G +LKS +L ++K++
Sbjct: 2504 RRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQN 2563
Query: 2405 PVPVPEKQISWEDKKATVVEIPRKFLGTMDKE--REVMGKYEPIPPHVLGT 2453
+ +K + + E+ T+ +E ++V + P P V GT
Sbjct: 2564 EQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGT 2614
Score = 113 bits (283), Expect = 2e-24
Identities = 290/1472 (19%), Positives = 605/1472 (41%), Gaps = 212/1472 (14%)
Query: 992 LTQKQETFREMQQQMIGEEPLDHLLG-MRATDLQILSTQVEQRLNENLTLSHRDEKPAFS 1050
+T++++ +E+Q+ E DHL G +R + L T+ E ++ H++ +
Sbjct: 1198 ITKERKVLKELQKSF--ETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE-----T 1250
Query: 1051 LDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKTKERDSKQ 1110
+D EL+ S+ T + ++ S + + + V Q+ L +K+ E +++
Sbjct: 1251 ID-----ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE--TQE 1303
Query: 1111 MSTEPGLLEDESGTE----AAPIEMEEASVYSQWSSSTSVIK-LSKDVDSQEK------- 1158
E LL ++S T+ A IEME + ++ S IK L+K+ D+ +
Sbjct: 1304 TMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEV 1363
Query: 1159 --DISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVT 1216
D K+HI TL ++Q+ + K++ Q L K +K + K+++E MEQ
Sbjct: 1364 KHDQLKEHIRETLAKIQESQSKQE-----QSLNMK-EKDNETTKIVSE------MEQFKP 1411
Query: 1217 K-----KVKIQGRGASGISGRRSTAGDG----SSWRDDLCRLMALRISGSQTKMSENLNA 1267
K +++I+ G+S R + D + +DDL RL + S S ++ EN+
Sbjct: 1412 KDSALLRIEIE---MLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESD-QLKENIKE 1467
Query: 1268 ELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIR-E 1326
+V +H E ++ KE + + +L ++ E + IQ+
Sbjct: 1468 ---------IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN 1518
Query: 1327 DMIQGVTQEVIRHKEVMP-REEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGK 1385
D +Q QE+ +E ++ + Q+K ++ +E + K + +E + +
Sbjct: 1519 DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA--KDSALQSIESKMLELTN 1576
Query: 1386 EISKKEEKKTFQKSPKQGRKAVQKERKVGKIK-REMTKE---ERDMSEEVEEMATLEEKV 1441
+ + +E+ K+ K VQ+ ++ + + +E TKE + S+E E V
Sbjct: 1577 RLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAV 1636
Query: 1442 VKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWE--KRLLQEEEKLHQA 1499
+ + K+ IE + +K + + E + + E E + + +E + L
Sbjct: 1637 NETQEKMCEIEHLKEQFETQKL--NLENIETENIRLTQILHENLEEMRSVTKERDDLRSV 1694
Query: 1500 GEKLSPEEEMLQEDKKL-------KWEEWKQVWENMLSSKSKEQQYKD--EEEVTLEEEV 1550
E L E + L+E+ + K EE K V ++ + + + E+ +
Sbjct: 1695 EETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM 1754
Query: 1551 SREGEEKEQQVTEEQRHIQEEHKWARIHRKRAR----------AEK--KRAQEERKLAQE 1598
++ E + + IQEE + A +H K + +EK K + ++ L
Sbjct: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
Query: 1599 EEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQ-KEETLAQRGEKLSQEAEK 1657
KL ++ ++L E +L + + +++++ E Q K+++L KL E
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTL--SKLEIENLN 1872
Query: 1658 LAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQRE----------QNL 1707
LAQK + ++ + V +E + L + L ++ L + ++E R+ + L
Sbjct: 1873 LAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARML 1932
Query: 1708 DWQEKELAQEL-EELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEE 1766
+ KE +L E++ ++S +++L++ + +L ++ ++L ++E L +E ++
Sbjct: 1933 SKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMS 1992
Query: 1767 ETKLAQEEELLIQ-EKEKLAQHKEKMP------------EEEERLGRKREQLIEKKMKLA 1813
K+ + E+L Q E + L+ +M EE + ++R++L K L
Sbjct: 1993 HKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLK 2052
Query: 1814 QKRERWINSMEELT----KNKMILYQKKNLAQEKKNLAQE-KEKLAQRKENLLYNKE--- 1865
+R+++I ++ E+ +N + +K+ L+ +++L + +EK ++ KE L E
Sbjct: 2053 MERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDD 2112
Query: 1866 ------RLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLA----ETEKK 1915
RL+ ++ ++ + +L M K + T+ E + ++ + KK
Sbjct: 2113 HYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKK 2172
Query: 1916 LVQVEDSLAKKQEKLAQEKMKLALE--------KAMVQGKKRLRGELDIAKEEKA---LN 1964
L V + K +E+ + K ++ K ++ + L+ + D+ E LN
Sbjct: 2173 LKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLN 2232
Query: 1965 LEMKRLAEEKMRLVEGKETLS-KGETPET-SRQRKMTQVEQELFERKLSLEEK---ILLH 2019
M EE ++ E S K E + S +++MTQ +E + +E+ I
Sbjct: 2233 QNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKE 2292
Query: 2020 EDRILAMEES------EIAKGKLEFTRGQ----RIFVQGQRKLAKASRKLIKKRESLSKE 2069
DRI + I EF + + Q + L + + KL K ++L
Sbjct: 2293 NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTS 2352
Query: 2070 PAKLNKILKALQK-----LTRDERKLTQEEIK-----MTKMKRALFVKERRLSIEQSKLD 2119
A ++ Q +T +LT E+I+ + + K + KE ++ Q +L+
Sbjct: 2353 LASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELE 2412
Query: 2120 IKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEE-----SKLARKHSEV 2174
+ D K + K K ++ ++ + K +EE KL + E
Sbjct: 2413 VTN-DIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEK 2471
Query: 2175 ILDDEE--------EGGIE-EEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDE------ 2219
+ + +E + +E ++EVI L+ R+ ++A+ E Q
Sbjct: 2472 MKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCG 2531
Query: 2220 ------------VESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE 2267
+ EH E E + +L++Q +++ E + EV+ +E
Sbjct: 2532 GGSGIVQNTKALILKSEHIRLEKE--ISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKE 2589
Query: 2268 ERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEV 2299
+ E ++ E + K KK+++
Sbjct: 2590 RTLKREAHKQVTCENSPKSPKVTGTASKKKQI 2621
Score = 95.9 bits (237), Expect = 5e-19
Identities = 283/1358 (20%), Positives = 540/1358 (39%), Gaps = 234/1358 (17%)
Query: 1523 QVWENMLSSKSKEQQYKDEEEVTLEEEVSR---EGEEKEQQVTEEQRHIQEEHKWARIHR 1579
++ +N L +K + V+ +E ++ K + T + + + +R
Sbjct: 290 RILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYR 349
Query: 1580 KRARAEKKRAQE----ERKLAQEEEKLAQ--EERQLAQ--EERKLAQAYVKITQDDREMA 1631
K KK+ +E R A E+++LAQ EE+ L Q + K+ +
Sbjct: 350 KEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTL 409
Query: 1632 QAEGKFAQKEETLAQRGE----KLSQEAEK------LAQKRKKLAKKW-----EKVAREE 1676
Q E K +K G+ K S A++ + K KL+ E V E
Sbjct: 410 QQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSES 469
Query: 1677 EKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELN 1736
+ + L+E++ A K+ ++N++ + L + + L D E+L ++EE+
Sbjct: 470 DVFSNTLDTLSEIEWNPATKL----LNQENIESELNSLRADYDNLVLDYEQLRTEKEEME 525
Query: 1737 QEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELL--IQEKEKLAQHKEKMPEE 1794
+ ++EK L +E EAL E +TK QE +L+ I + L +H E ++
Sbjct: 526 LK----LKEKNDL-DEFEAL--------ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQD 572
Query: 1795 EERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
E + +L+ +K +K + +I+S ++L KM L ++ K Q K+ L
Sbjct: 573 LENELSSKVELLREKEDQIKKLQEYIDS-QKLENIKMDLSYSLESIEDPK---QMKQTLF 628
Query: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
+ L K + + +++K K+ Q+E + + + KK+ + EK
Sbjct: 629 DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK 688
Query: 1915 KLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKR---LA 1971
+L + + K + + K L ++GK I +K LN E++ L
Sbjct: 689 ELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK--------ITDLQKELNKEVEENEALR 740
Query: 1972 EEKMRLVEGKETLSKGETPETSRQRKMTQVEQE----LFERKLSLEEKILLHEDRILAME 2027
EE + L E K S E R RK Q + E + K L +++ E R+ +
Sbjct: 741 EEVILLSELKSLPS-----EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLL 795
Query: 2028 ESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKE-PAKLNKILKALQKLTRD 2086
E EI K K + Q + K++ + + ++L + K +L+ +++ ++
Sbjct: 796 E-EIGKTKDDLATTQSNY--------KSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQE 846
Query: 2087 ERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKL 2146
L++E K AL +++L K + EK E+ + ++ + + +L
Sbjct: 847 IVNLSKEAQKFDSSLGAL----------KTELSYKTQELQEKTREVQERLNEMEQLKEQL 896
Query: 2147 ANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRG 2206
N+ + E + T KL + EV +E+ +++ + ++R
Sbjct: 897 ENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIER----------- 945
Query: 2207 DKPKEKFSSQVD-EVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREE 2265
D+ K V+ ++++E +ESL E +L S+ EE EE E
Sbjct: 946 DQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEEN-TGET 1004
Query: 2266 EEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEV-----------QEKEEVFEEKEEIMS 2314
++E +++ G +K+ + E + + + K E+ QEK E+ + E +++
Sbjct: 1005 KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIA 1064
Query: 2315 EEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVP 2374
E+E +E E + +EE+ + LKK+++ QE
Sbjct: 1065 EKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQE-------------------- 1104
Query: 2375 HGKGRAIRL-GVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKATVVEIPRKFLGTM 2433
K AI+ G L +L ++KEK+ + EKQ ++ L
Sbjct: 1105 --KNHAIKKEGELSRTCDRLAEVEEKLKEKSQ-QLQEKQ--------------QQLLNVQ 1147
Query: 2434 DKEREVMGKYEPIPPHVLGTVLESQAQDLKTPFMSHILRRTVEAEELQHKPLGAWWKWFL 2493
++ E+ K I ++LK EL++K L L
Sbjct: 1148 EEMSEMQKKINEI-------------ENLKN--------------ELKNKELT------L 1174
Query: 2494 QHPPLMGQTEVQLPLSQIPAKEQHADVSLSDVEWIRHVLERMEAGEQLSRDGFHRLCQLL 2553
+H +TE +L L+Q E + +V E R VL+ ++ + RD + +
Sbjct: 1175 EHM----ETE-RLELAQ-KLNENYEEVKSITKE--RKVLKELQKSFETERDHLRGYIREI 1226
Query: 2554 K--DLASKGNLE--WLHLAKHEAIVYRHRQALESQDTRISSRQSMSPKYLKVIP--PIKA 2607
+ L +K L+ +HL +H+ + R+++ + +I + Q + + K+ P+
Sbjct: 1227 EATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLH 1286
Query: 2608 KEKESWPKPLAVPTQKSPLATKRIPDPRAKNWHLLGEPYRSERAQQISIAHKEMEM---- 2663
+E+E P V + + LL E +S ++A EME
Sbjct: 1287 EEQELLPNVKEVSETQETM----------NELELLTE--QSTTKDSTTLARIEMERLRLN 1334
Query: 2664 QYFYPATRDIFPSAHASVEKQTLALMFQKDFWDFK-DKRRFPKLPKLEKKTQPISKKKEE 2722
+ F + +I S+ K+ L K+ + K D+ + L K + SK+++
Sbjct: 1335 EKFQESQEEI-----KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQS 1389
Query: 2723 LPLWETFVALYHVLRMLQQRYPKDSTAWMEQFYQLMDLY--------QLKSPRIQK---- 2770
L + E ++ ++Q PKDS A + +++ L ++KS +K
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDS-ALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQ 1448
Query: 2771 LLQELLMREEPQPQEIIYEEALKATELVPGERL-FCCL 2807
LQE+L E Q +E I E K E ++ CCL
Sbjct: 1449 RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL 1486
Score = 52.8 bits (125), Expect = 5e-06
Identities = 172/932 (18%), Positives = 373/932 (40%), Gaps = 137/932 (14%)
Query: 959 LAQGLMDKDERVRIKTLSLMAEIGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGM 1018
+ + L ++ ++ + L + E+ R + + L ++QET +++ I E D L M
Sbjct: 1754 MQKDLEHSNDALKAQDLKIQEEL----RIAHMHLKEQQETIDKLRG--IVSEKTDKLSNM 1807
Query: 1019 RATDLQILSTQVEQRL-----NENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVS---- 1069
+ DL+ + ++++++ NE+ ++ + + VS +LK +K +++
Sbjct: 1808 QK-DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKL 1866
Query: 1070 ---------------EESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKTKERDSK-QMST 1113
EE + +K RR + +K + L++TK RD + Q
Sbjct: 1867 EIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQEL 1926
Query: 1114 EPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQ 1173
+ + + E E+ S + + + KD+D + ++ K L K LQ
Sbjct: 1927 KTARMLSKEHKETVDKLREKIS-----EKTIQISDIQKDLDKSKDELQKKIQELQKKELQ 1981
Query: 1174 KIRDKRDKKATAQKLKKKHK-KKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGR 1232
+R K D + +K+ + + KK EA+ ++ ++ Q +TKK+ +
Sbjct: 1982 LLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQ-LTKKLH------ESLEEI 2034
Query: 1233 RSTAGDGSSWRDDLCRLM------------ALRISGSQTKMSENLNAE--LVTFAQEMLV 1278
R A + RD+L R+ LR ++ + + + E L++ Q+ L
Sbjct: 2035 RIVAKE----RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLT 2090
Query: 1279 DRHPSWELFQEICPLLKKESKV-----LLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVT 1333
+ E I LLK+ S++ L L D+ EK+ F +E ++R +
Sbjct: 2091 ESLR--EKCSRIKELLKRYSEMDDHYECLNRLSLDL---EKEIEFQKELSMRVKANLSLP 2145
Query: 1334 QEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEK 1393
+H E + ++ E I+KK K V+ VT KE E+
Sbjct: 2146 YLQTKHIEKLFTANQRCSM---------EFHRIMKKLKYVL----SYVTKIKE----EQH 2188
Query: 1394 KTFQKSPKQGRKAVQKER----KVGKIKREM---TKEERDMS----------EEVEEMAT 1436
++ K V+K++ K+ ++++ ++E RD+ E +++ +
Sbjct: 2189 ESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSE 2248
Query: 1437 LEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKL 1496
E +K E + V+ R ++ + +EW + K ++E R+ Q
Sbjct: 2249 SEFPSIKTEFQQVLSNR----KEMTQFLEEWLNTRFDIEKLKNGIQKE-NDRICQVNNFF 2303
Query: 1497 HQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE 1556
+ + E +E +EW+Q +++ + E+ +K+ + + + S
Sbjct: 2304 NNRIIAIMNESTEFEERSATISKEWEQDLKSL--KEKNEKLFKNYQTL----KTSLASGA 2357
Query: 1557 KEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEE-KLAQEERQLAQEERK 1615
+ T++ ++ + ++ ++ R + E ++ A +E K+ + +++L
Sbjct: 2358 QVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDI 2417
Query: 1616 LAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVARE 1675
+A+ K+ + ++ + + + ++ +A + +E E L K K+ + K A+E
Sbjct: 2418 IAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKE 2477
Query: 1676 EEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSW----- 1730
EK E + + + + E +R Q Q+ + E + + + L+
Sbjct: 2478 FEKEISATKATVEYQKEVIRLLRENLRRSQQA--QDTSVISEHTDPQPSNKPLTCGGGSG 2535
Query: 1731 -----KEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLA 1785
K L E +L +E KL ++ E L Q+ +L L+ E + + K
Sbjct: 2536 IVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKRE 2595
Query: 1786 QHK----EKMPEEEERLG--RKREQLIEKKMK 1811
HK E P+ + G K++Q+ + K
Sbjct: 2596 AHKQVTCENSPKSPKVTGTASKKKQITPSQCK 2627
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 165 bits (418), Expect = 5e-40
Identities = 212/997 (21%), Positives = 463/997 (46%), Gaps = 132/997 (13%)
Query: 1419 EMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSW 1478
++T++E ++ + EE+ ++EK K EG+L +E ++ H + +
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGEL----------------EEMERKHQQLLE-- 887
Query: 1479 KAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQY 1538
EK +L E+ QA +L E E ++ K +E +++ + L S+ +E++
Sbjct: 888 -------EKNILAEQ---LQAETELFAEAEEMRARLAAKKQELEEILHD-LESRVEEEEE 936
Query: 1539 KDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQE 1598
+++ ++++ ++ E+Q+ EE+ Q+ ++ + A A+ K+ +EE L ++
Sbjct: 937 RNQILQNEKKKMQAHIQDLEEQLDEEEGARQK----LQLEKVTAEAKIKKMEEEILLLED 992
Query: 1599 EEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKL 1658
+ +E++L ++ ++A+ ++ +++ E A+ K K+E + E+ ++ EK
Sbjct: 993 QNSKFIKEKKLMED--RIAECSSQLAEEE-EKAKNLAKIRNKQEVMISDLEERLKKEEKT 1049
Query: 1659 AQKRKKLAKKWEKVARE-EEKLAKKGGKLAEVKNILAQKVEELP---QREQNLDWQEKEL 1714
Q+ +K +K + + ++++A+ ++ E+K LA+K EEL R + +
Sbjct: 1050 RQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNA 1109
Query: 1715 AQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEE 1774
+ + EL+ + EL E K ++K+ L+EE EAL + +L + A ++
Sbjct: 1110 LKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEAL---KTELEDTLDTTAAQQ 1166
Query: 1775 ELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKN-KMIL 1833
EL + ++++A+ K+ + EE + + ++ R+R ++EEL++ +
Sbjct: 1167 ELRTKREQEVAELKKALEEETK----------NHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 1834 YQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEE 1893
K NL + K+ L + ++LA + L K H +K K+ AQV+E
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRK-------------KLDAQVQE 1263
Query: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
+ E + + +LAE KL D+++ E+ ++ +K A + A ++ + + E
Sbjct: 1264 LHAKVSEG-DRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322
Query: 1954 LDIAKEEKALNL--EMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKL- 2010
L + + LNL +++L EEK L E +E + E + ++++ ++ +L + K
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQE---EEEEARKNLEKQVLALQSQLADTKKK 1379
Query: 2011 ---------SLEE--KILLHEDRILA--MEESEIAKGKLEFTRGQ--------RIFVQGQ 2049
SLEE K LL + L+ +EE +A KLE T+ + + + Q
Sbjct: 1380 VDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ 1439
Query: 2050 RKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKER 2109
R++A K KK + L E ++ + ++ R E + ++E K + RAL
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEEKSIS--ARYAEERDRAEAEAREKETKALSLARAL----- 1492
Query: 2110 RLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLAR 2169
+ L+ KE +F + +L D + L + + + + K ++ E++ + R
Sbjct: 1493 -----EEALEAKE-EFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRALEQQVEEMR 1545
Query: 2170 KHSEVILDD---EEEGGIEEEEVIPFLKRRWRKRKEAK--RGDKPKEKFSSQVDEVESEE 2224
E + D+ E+ + E + +K ++ + + + + ++ K QV E+E+E
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1605
Query: 2225 HFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEV----REEEEERKE-EEEGEEKQ 2279
+ +L +K+ + ++ E + E + +EV R+ + + K+ + E EE +
Sbjct: 1606 EDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEAR 1665
Query: 2280 VEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEE----------- 2328
++E + K+ EKK + ++ E+ + +EE+ S E +++E +E
Sbjct: 1666 ASRDEIFAQSKESEKKLKSLE--AEILQLQEELASSERARRHAEQERDELADEITNSASG 1723
Query: 2329 ESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRER 2365
+S L+E+ E I + E++ + ++ + L R R
Sbjct: 1724 KSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760
Score = 157 bits (396), Expect = 2e-37
Identities = 259/1159 (22%), Positives = 490/1159 (42%), Gaps = 130/1159 (11%)
Query: 1252 LRISGSQTKMSENLNAELVTFAQEMLVDRH-------PSWELFQEICPLL------KKES 1298
L++ QTK+ L E+ Q++L +++ ELF E + K+E
Sbjct: 862 LKVKEKQTKVEGELE-EMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQEL 920
Query: 1299 KVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDML 1358
+ +L DL+ V E+ R ++Q +++ H + + E+ ++ AR L
Sbjct: 921 EEILHDLESRVEEEEE----------RNQILQNEKKKMQAHIQDL-EEQLDEEEGARQKL 969
Query: 1359 GLEETQV---ILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGK 1415
LE+ I K ++++ LE N KE KK + + Q + +K + + K
Sbjct: 970 QLEKVTAEAKIKKMEEEILLLEDQNSKFIKE--KKLMEDRIAECSSQLAEEEEKAKNLAK 1027
Query: 1416 IKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETR 1475
I+ + D+ E +++ +++ K + KL D + E + E +
Sbjct: 1028 IRNKQEVMISDLEERLKKEEKTRQELEKAKRKL-----DGETTDLQDQIAELQAQIDELK 1082
Query: 1476 KSWKAWKEEWEKRLLQ-EEEKLHQAG-----EKLSPEEEMLQEDKKLKWEEWKQVWENML 1529
+EE + L + ++E LH+ +L + LQED + + + +
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 1530 SSKSKEQQYKDEEEVTLEEEVSREG--EEKEQQVTEEQRHIQEEHKWARIHRKRARAEKK 1587
+ + K E E TL+ +++ ++EQ+V E ++ ++EE K + R
Sbjct: 1143 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202
Query: 1588 RAQEERKLAQEEEK-----LAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKF--AQK 1640
A EE E+ K L + ++ L + ++LA VK+ Q + ++ + K AQ
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELA-CEVKVLQQVKAESEHKRKKLDAQV 1261
Query: 1641 EETLAQ--RGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVE 1698
+E A+ G++L E LA+K KL + + V+ E+ KKG K A+ L +++
Sbjct: 1262 QELHAKVSEGDRLRVE---LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318
Query: 1699 ELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAW 1758
+ + Q Q+ L+ + +LE + L ++EE +EE + EK+ LA + +
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE--EEEARKNLEKQVLALQSQLADT 1376
Query: 1759 QR---------EKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKK 1809
++ E L E + KL ++ E L Q E+ A +K+ + + RL +++L +
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRL---QQELDDLT 1433
Query: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869
+ L +R+ N ++ K +L ++K+++ E A+ KE + L
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS---LAR 1490
Query: 1870 SKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEK 1929
+ ++ ++ K + NK L E L K+ V K +L ++++ L Q + + + E+
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEE 1550
Query: 1930 L-----AQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETL 1984
L A E KL LE M K + +L E+ N E KRL +++R +E
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ---NEEKKRLLIKQVRELE----- 1602
Query: 1985 SKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRI 2044
E + +QR + ++K+ ++ K L + E+ K +L + Q
Sbjct: 1603 --AELEDERKQRALAVAS----KKKMEIDLKDLEAQIEAANKARDEVIK-QLRKLQAQMK 1655
Query: 2045 FVQGQRKLAKASRKLI--------KKRESLSKEPAKLNKILKALQKLTR----DERKLTQ 2092
Q + + A+ASR I KK +SL E +L + L + ++ R + +L
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Query: 2093 EEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKD----------------- 2135
E K AL ++RRL ++L+ +E + + EL D
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLE-EELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 2136 -EKKLARKQRKLANKMRRMINKE--EKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPF 2192
E+ A+K ++ R NKE K+ E E + K I E + G EE++
Sbjct: 1775 AERSAAQKSDNARQQLERQ-NKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQE 1833
Query: 2193 LKRRWRKRKEAKRGDKP-KEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEER 2251
K R K +R +K KE F DE + + E+ME + KQ EE EE
Sbjct: 1834 AKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM-KQLKRQLEEAEEE 1892
Query: 2252 EEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEE 2311
+++ E ++ E EG ++V + ++ + ++ E
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGAS 1952
Query: 2312 I-MSEEETESLSDEEEEEE 2329
+ +S+++TES + + E +
Sbjct: 1953 LELSDDDTESKTSDVNETQ 1971
Score = 156 bits (394), Expect = 3e-37
Identities = 196/813 (24%), Positives = 363/813 (44%), Gaps = 84/813 (10%)
Query: 1573 KWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQ 1632
+W R+ K + QEE A++EE L +E+Q T+ + E+ +
Sbjct: 833 QWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQ---------------TKVEGELEE 877
Query: 1633 AEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNI 1692
E K Q E E+L E E A+ + A+ LA K +L E+ +
Sbjct: 878 MERKHQQLLEEKNILAEQLQAETELFAEAEEMRAR-----------LAAKKQELEEILHD 926
Query: 1693 LAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEE 1752
L +VEE +R Q L ++K++ +++LE ++E ++L E+ + KK+ EE
Sbjct: 927 LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEE 986
Query: 1753 EEALAWQREKLSEE----ETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEK 1808
L Q K +E E ++A+ L +E+EK A++ K+ ++E + E+ ++K
Sbjct: 987 ILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK-AKNLAKIRNKQEVMISDLEERLKK 1045
Query: 1809 KMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLT 1868
+ K Q+ E+ ++ T + + +A+ + + + K +LA+++E L + L
Sbjct: 1046 EEKTRQELEKAKRKLDGETTD-----LQDQIAELQAQIDELKLQLAKKEEEL---QGALA 1097
Query: 1869 HSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQE 1928
+ + N L + ++ AQ+ E QE K AE +K+ L+++ E
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAE--LQEDFESEKASRNKAEKQKR------DLSEELE 1149
Query: 1929 KLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGE 1988
L E ++ L+ Q + R + E ++A+ +KAL E K E +++ + + + E
Sbjct: 1150 ALKTE-LEDTLDTTAAQQELRTKREQEVAELKKALEEETKN-HEAQIQDMRQRHATALEE 1207
Query: 1989 TPETSRQRKMTQVEQELFERKLSLEEKILLHEDRIL--AMEESEIAKGKLE--------- 2037
E Q K + E ++ L + K L E ++L ESE + KL+
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK 1267
Query: 2038 FTRGQRIFVQGQRKLAKASRKLIKKR---ESLSKEPAKLNKILKALQKLTRDERKLTQEE 2094
+ G R+ V+ K +K +L E K+ K K +L+ +D ++L QEE
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE 1327
Query: 2095 IKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMI 2154
T+ K L + R+L E++ L ++ + E R L EK++ Q +LA+ +++
Sbjct: 1328 ---TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL---EKQVLALQSQLADTKKKV- 1380
Query: 2155 NKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFS 2214
++ T E + A+K +++ D E EE+ + + K K + + D
Sbjct: 1381 -DDDLGTIESLEEAKK--KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD 1437
Query: 2215 SQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEE-------EVREEEE 2267
Q + E ++ + LL E EK S EE +R E E RE+E EE
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAE-EKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496
Query: 2268 ERKEEEEGEEKQVEKEEEEKKKKKKE--KKKEEVQEKEEVFEEKEEIMSEEETESLSDEE 2325
E KEE E + KQ+ + E+ K + K E+++ + E++ E M + E L DE
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEM-RTQLEELEDEL 1555
Query: 2326 EEEESCSLEEEVDREKEILKKEKQFKLQEQRRK 2358
+ E L EV+ + + E+ + ++++ +
Sbjct: 1556 QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588
Score = 156 bits (394), Expect = 3e-37
Identities = 245/1130 (21%), Positives = 485/1130 (42%), Gaps = 163/1130 (14%)
Query: 1325 REDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKK---GKKVIFLEPGNV 1381
+E+ +Q +E+++ KE + E + ++ R L E + IL + + +F E +
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 1382 TMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKV 1441
K+E ++ + + ++ + + K++M +D+ E+++E +K+
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL 969
Query: 1442 VKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGE 1501
+E+ + KK +E + + K K EK+L+ E+++ +
Sbjct: 970 --------QLEKVTAEAKIKKMEEEILLLEDQNSKFIK------EKKLM--EDRIAECSS 1013
Query: 1502 KLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQV 1561
+L+ EEE + K++ ++ E M+S EE + EE+ +E E+ ++++
Sbjct: 1014 QLAEEEEKAKNLAKIRNKQ-----EVMISDL--------EERLKKEEKTRQELEKAKRKL 1060
Query: 1562 TEEQRHIQEE--HKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQA 1619
E +Q++ A+I + + KK + + LA+ +++ + L + R+L QA
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL-KVVREL-QA 1118
Query: 1620 YVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKL 1679
+ Q+D E +A A+K++ LS+E E L + +L + A ++E
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQK------RDLSEELEAL---KTELEDTLDTTAAQQELR 1169
Query: 1680 AKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEE 1739
K+ ++AE+K L EE E + + A LEEL +E+ + L + +
Sbjct: 1170 TKREQEVAELKKALE---EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 1740 GKLVEEKKKLAEEEEALAWQREKLSEEETKL-AQEEELLIQEKE------KLAQHKEKMP 1792
L + K+LA E + L + + + KL AQ +EL + E +LA+ K+
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 1793 EEEERLGRKREQLIEKKMKLAQKR---ERWINSMEEL----TKNKMILYQK-KNLAQEKK 1844
E + + E+ +K +K A+ E + +EL T+ K+ L + + L +EK
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346
Query: 1845 NLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNK----LGMFNKILAQVEEKLTQEKE 1900
+L +++E+ + ++NL ++++ + QL K K LG L + ++KL ++ E
Sbjct: 1347 SLQEQQEEEEEARKNL---EKQVLALQSQLADTKKKVDDDLGTIES-LEEAKKKLLKDAE 1402
Query: 1901 TVIKKKE-------KLAETEKKLVQ--------------VEDSLAKKQEKLAQEKMKLAL 1939
+ ++ E KL +T+ +L Q V +L KKQ+K Q LA
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ---LLAE 1459
Query: 1940 EKAMVQ--GKKRLRGELDIA-KEEKALNL----------------EMKRLAEEKMRLVEG 1980
EK++ ++R R E + KE KAL+L + K+L + L+
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS 1519
Query: 1981 KETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR 2040
K+ + K +R + Q +E+ + LE+++ ED L +E + A K +F R
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM-KAQFER 1578
Query: 2041 G-----------QRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERK 2089
+R+ ++ R+L K+R K+ LK L+ K
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638
Query: 2090 LTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSE--LTKDEKKLARKQRKLA 2147
E IK + +A +K+ + +E+++ E K SE L E ++ + Q +LA
Sbjct: 1639 ARDEVIKQLRKLQAQ-MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELA 1697
Query: 2148 NKMRRMINKEEKMTEEESKLARKHS--EVILDDE----------EEGGIEEEEVIPFLKR 2195
+ R + E++ E ++ S +LD++ EE EE+ + L
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 2196 RWRK---------------RKEAKRGDKPKEKFSSQVDEV-----ESEEHFSEEMESLLD 2235
R+RK R A++ D +++ Q E+ E E + ++ +
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATIS 1817
Query: 2236 ELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKK 2295
LE + + EE+ +E +ER E+K +E + + E+ ++ K++ EK
Sbjct: 1818 ALEAK--IGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKA 1875
Query: 2296 KEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILK 2345
+++ + EE EE + + E +++ E + RE LK
Sbjct: 1876 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925
Score = 77.8 bits (190), Expect = 1e-13
Identities = 172/827 (20%), Positives = 342/827 (41%), Gaps = 122/827 (14%)
Query: 1954 LDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLE 2013
L + ++E+ L + +E++ V+ K+T +GE E R+ + E+ + +L E
Sbjct: 845 LQVTRQEEELQAK-----DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 2014 EKILLHEDRI---LAMEESEIAK------GKLEFTRGQRIFVQGQRKLAKASRKLIKKRE 2064
++ + + LA ++ E+ + ++E + +Q ++K +A + ++ E
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE--E 957
Query: 2065 SLSKEPAKLNKILKALQKLTRDER-KLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEW 2123
L +E K+ L+K+T + + K +EEI + + + + F+KE++L ++
Sbjct: 958 QLDEEEGARQKL--QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR-------- 1007
Query: 2124 DFSEKRSELTKDEKKLARKQRKLANKMRRMIN------KEEKMTEEESKLARKHSEVILD 2177
+E S+L ++E+K A+ K+ NK MI+ K+E+ T +E + A++ +
Sbjct: 1008 -IAECSSQLAEEEEK-AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1065
Query: 2178 DEEEGGIEEEEVIPFLKRRWRKRKEAKRG------DKPKEKFSS-------QVDEVESEE 2224
D ++ E + I LK + K++E +G D+ K ++ Q E +E
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125
Query: 2225 HFSEEMESLLDELEKQESLSSEEEEEREEEEE---------REEEEVREEE-EERKEEEE 2274
F E S ++ EKQ+ SEE E + E E +E RE+E E K+ E
Sbjct: 1126 DFESEKASR-NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 2275 GEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLE 2334
E K E + ++ +++ +E ++ E+ K + E+ + + + +E +C ++
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL---EKNKQGLETDNKELACEVK 1241
Query: 2335 --EEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKK 2392
++V E E +K+ ++QE K G + + A + L++ L
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVEL----------AEKASKLQNELDN 1291
Query: 2393 LMSTALEMKEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKEREVMGKYEPIPPHVLG 2452
+ST LE EK + + S E + E+ ++ R+ +
Sbjct: 1292 -VSTLLEEAEKKGIKFAKDAASLESQLQDTQEL------LQEETRQKLN----------- 1333
Query: 2453 TVLESQAQDLKTPFMSHILRRTVEAEELQHKPLGAWWKWFLQHPPLMGQT--EVQLPLSQ 2510
L S+ + L+ + L+ E EE K L K L + T +V L
Sbjct: 1334 --LSSRIRQLEEE--KNSLQEQQEEEEEARKNLE---KQVLALQSQLADTKKKVDDDLGT 1386
Query: 2511 IPAKEQHADVSLSDVEWIRHVLERMEAGEQLSRDGFHRLCQLLKDLA--------SKGNL 2562
I + E+ L D E + LE +RL Q L DL NL
Sbjct: 1387 IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNL 1446
Query: 2563 EWLH------LAKHEAIVYRHRQALESQDTRISSRQSMSPKYLKVI-PPIKAKEKESWPK 2615
E LA+ ++I R+ + + + +++ + + + ++AKE+
Sbjct: 1447 EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506
Query: 2616 PLAVPTQKSPLATKRIPDPRAKNWHLLGEPYRSERAQQISIAHKEMEMQYFYPATRDIFP 2675
+ +++K D KN H L + R+ Q + + E++ AT D
Sbjct: 1507 KQLRADMEDLMSSK---DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED--A 1561
Query: 2676 SAHASVEKQTLALMFQKDFWDFKDKRRFPKLPKLEKKTQPISKKKEE 2722
V Q + F++D +D++ K L K+ + + + E+
Sbjct: 1562 KLRLEVNMQAMKAQFERDL-QTRDEQNEEKKRLLIKQVRELEAELED 1607
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapiens]
Length = 436
Score = 162 bits (410), Expect = 4e-39
Identities = 85/407 (20%), Positives = 245/407 (60%), Gaps = 20/407 (4%)
Query: 1482 KEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE 1541
K E +K L +E ++ + ++ +E ++E + E+ QV E + +E Q +++
Sbjct: 40 KLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 99
Query: 1542 EEVTLEEE---VSREGEEKEQ--QVTEEQRHIQEEHKWARIHRKRARAEKKRAQE-ERKL 1595
E E+E +EG+ +EQ QV E++ ++E+ R + R ++ + +E E ++
Sbjct: 100 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 159
Query: 1596 AQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEA 1655
++E ++ ++E Q+ ++E ++ + ++ + + +M + EG+ ++EE + ++ E++ ++
Sbjct: 160 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQE 219
Query: 1656 EKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELA 1715
E++ ++ +++ K+ E++ +EE++ K+ ++ + + + ++ E++ ++E+ + QE+++
Sbjct: 220 EQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQML 279
Query: 1716 QELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEE 1775
++ E+ E +EE+ ++E ++ E+++++ E+EE + Q E++ E+E ++ ++EE
Sbjct: 280 KQKEQTE--------QEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEE 331
Query: 1776 LLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQ 1835
+ ++KE++ + KE+M ++EE++G + EQ+ +++ ++ ++ E+ E++ K Q
Sbjct: 332 QMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRK------Q 385
Query: 1836 KKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLG 1882
++ + ++++ + ++KE++ ++KE + +E++ K+Q+ + + +G
Sbjct: 386 EEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMG 432
Score = 154 bits (390), Expect = 9e-37
Identities = 81/444 (18%), Positives = 265/444 (59%), Gaps = 18/444 (4%)
Query: 1494 EKLHQAGEKLSPEEEMLQEDK---KLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEV 1550
E+L + +L E ++++ +K +L +E K+ E +E Q +++E E+E
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQE- 65
Query: 1551 SREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLA 1610
+ E+E QV E++ ++E+ R + R ++E ++ ++E ++ ++E Q+
Sbjct: 66 -GQVREQEGQVREQEGQVREQEGQVREQEGQVR------EQEGQVREQEGQVREQEGQVR 118
Query: 1611 QEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWE 1670
++E ++ + ++ + + ++ + EG+ ++E + ++ ++ ++ ++ ++ ++ ++
Sbjct: 119 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 178
Query: 1671 KVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSW 1730
+V +E ++ ++ G++ E + + ++ E++ ++E+ + QE+++ ++ E++ E++
Sbjct: 179 QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238
Query: 1731 KEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEK 1790
+EE++ ++E ++ ++++++ ++EE + Q E++ E+E ++ +++E QE E+ + +E+
Sbjct: 239 QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQE-EQTGEQEEQ 297
Query: 1791 MPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEK 1850
M E+EE++ + EQ+ E++ ++ ++ E+ E++ + QK+ + ++K+ + +++
Sbjct: 298 MREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE------QKEQMWEQKEQMWKQE 351
Query: 1851 EKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLA 1910
E++ +++E + +E++ ++Q+ + + ++ + + + EE++ ++KE + ++KE++
Sbjct: 352 EQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR 411
Query: 1911 ETEKKLVQVEDSLAKKQEKLAQEK 1934
E E+++ + ++ + K++E + ++K
Sbjct: 412 EQEEQMGEQKEQMRKQEEHMGEQK 435
Score = 148 bits (374), Expect = 7e-35
Identities = 68/435 (15%), Positives = 261/435 (60%), Gaps = 16/435 (3%)
Query: 1551 SREGEEKEQQVTEEQRHIQEEHKWARIH----RKRARAEKKRAQEERKLAQEEEKLAQEE 1606
+ E +EK ++ EE + ++ E ++H +++ +K +E ++ ++E ++ ++E
Sbjct: 6 NEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQE 65
Query: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA 1666
Q+ ++E ++ + ++ + + ++ + EG+ ++E + ++ ++ ++ ++ ++ ++
Sbjct: 66 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 125
Query: 1667 KKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDME 1726
++ +V +E ++ ++ G++ E + + ++ ++ ++E + QE ++ ++ ++
Sbjct: 126 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 185
Query: 1727 ELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQ 1786
++ +E ++ ++EG++ E+++++ E+EE + Q E++ E+E ++ ++EE + +++E++ +
Sbjct: 186 QVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQK 245
Query: 1787 HKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL-------TKNKMILYQKKNL 1839
+E++ ++EE++ ++ EQ+ E++ ++ ++ E+ + E+ + + + Q++ +
Sbjct: 246 QEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQM 305
Query: 1840 AQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEK 1899
++++ + +++E++ +++E + +E++ K+Q+ + K ++ + + + EE++ +++
Sbjct: 306 REQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQE 365
Query: 1900 ETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKE 1959
E V K++E++ + E+++ + E+ + K++E++ ++K ++ +K ++ ++ GE +
Sbjct: 366 EQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGE-----Q 420
Query: 1960 EKALNLEMKRLAEEK 1974
++ + + + + E+K
Sbjct: 421 KEQMRKQEEHMGEQK 435
Score = 126 bits (317), Expect = 3e-28
Identities = 103/486 (21%), Positives = 247/486 (50%), Gaps = 86/486 (17%)
Query: 1299 KVLLEDLDWDVVP-PEKKPIFIQEGAIREDMIQGVTQE-VIRHKEVMPREEEQAQKKARD 1356
K L L+ D +P P++ + QEG +RE Q QE +R +E RE+E ++
Sbjct: 35 KELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 94
Query: 1357 MLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKI 1416
+ +E QV ++G+ +E++ ++ Q R ++E +V +
Sbjct: 95 QVREQEGQVREQEGQV-----------------REQEGQVREQEGQVR---EQEGQVREQ 134
Query: 1417 KREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRK 1476
+ ++ ++E + E+ ++ E +V +QEG++ ++ G+ R+
Sbjct: 135 EGQVREQEGQVREQEGQVREQEGQVREQEGQV-------------------REQEGQVRE 175
Query: 1477 SWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQ 1536
+E+ + QE + Q G+ EE+M +++++++ K +EQ
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQ--------------KQEEQ 221
Query: 1537 QYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLA 1596
+ EE++ +EE + GE++EQ +E E+ + QEE+
Sbjct: 222 MGEQEEQMRKQEE--QMGEQEEQVQKQE--------------------EQVQKQEEQMRK 259
Query: 1597 QEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAE 1656
QEE+ QEE+ QEE+ L Q +E + E + ++EE + ++ E++ ++ E
Sbjct: 260 QEEQMREQEEQMREQEEQMLKQ---------KEQTEQEEQTGEQEEQMREQEEQMREQEE 310
Query: 1657 KLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQ 1716
++ ++ +++ ++ E++ ++EE++ ++ ++ E K + ++ E++ ++E+ + QE+++ +
Sbjct: 311 QMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRK 370
Query: 1717 ELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEEL 1776
+ E++ E++ +EE++ ++E ++ E+K+++ E++E + Q E++ E++ ++ ++EE
Sbjct: 371 QEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEH 430
Query: 1777 LIQEKE 1782
+ ++KE
Sbjct: 431 MGEQKE 436
Score = 121 bits (303), Expect = 1e-26
Identities = 92/449 (20%), Positives = 240/449 (53%), Gaps = 23/449 (5%)
Query: 1888 LAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGK 1947
+ ++ + +EK ++++ +L ETEK +Q+ + + + KL +K+ L E + + +
Sbjct: 1 MPRITNEELKEKNAELQEELQLVETEKSEIQLH--IKELKRKLETDKIPLPQEGQVREQE 58
Query: 1948 KRLRGELDIAKEEKALNLEMK---RLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQE 2004
++R + +E++ E + R E ++R EG+ +G+ E Q + + +
Sbjct: 59 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 118
Query: 2005 LFERKLSLEEKILLHEDRILAMEESEIAK--GKLEFTRGQRIFVQGQRKLAKASRKLIKK 2062
E ++ +E + ++ + +E ++ + G++ GQ V+ Q + +++
Sbjct: 119 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ---VREQEGQVREQEGQVRE 175
Query: 2063 RESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKE 2122
+E +E ++ + ++ E ++ ++E +M + + + +E ++ ++ ++ +E
Sbjct: 176 QEGQVREQE--GQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQE 233
Query: 2123 WDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEG 2182
E+ ++ K E+++ +++ ++ + +M +EE+M E+E ++ ++ + + EE+
Sbjct: 234 EQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQT--EQEEQT 291
Query: 2183 GIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQES 2242
G E+EE + + + R+++E R + +E+ Q +++ +E E + + E ++Q
Sbjct: 292 G-EQEEQMREQEEQMREQEEQMR--EQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMW 348
Query: 2243 LSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKE--KKKEEVQ 2300
E+ E+EE+ +++EE+VR++EE+ +++EE Q+ K+EE+ +K++++ ++KE++
Sbjct: 349 KQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE----QMRKQEEQMRKQEEQMGEQKEQMG 404
Query: 2301 EKEEVFEEKEEIMSEEETESLSDEEEEEE 2329
E++E E+EE M E++ + EE E
Sbjct: 405 EQKEQMREQEEQMGEQKEQMRKQEEHMGE 433
Score = 118 bits (295), Expect = 1e-25
Identities = 91/448 (20%), Positives = 237/448 (52%), Gaps = 32/448 (7%)
Query: 1906 KEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNL 1965
KEK AE +++L VE ++ Q + + K KL +K + + ++R + +E++
Sbjct: 10 KEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEG--- 66
Query: 1966 EMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILA 2025
R E ++R EG+ +G+ E Q + + + E ++ +E + ++ +
Sbjct: 67 -QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 125
Query: 2026 MEESEIAK--GKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKL 2083
+E ++ + G++ GQ V+ Q + ++++E +E ++ + ++
Sbjct: 126 EQEGQVREQEGQVREQEGQ---VREQEGQVREQEGQVREQEGQVREQE--GQVREQEGQV 180
Query: 2084 TRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQ 2143
E ++ ++E +M + + + +E ++ ++ ++ +E E+ ++ K E+++ ++
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQE 240
Query: 2144 RKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEA 2203
+ + K+E+ +++ + RK E + + EE+ +EE++ LK++ + +E
Sbjct: 241 EQ--------VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQM---LKQKEQTEQEE 289
Query: 2204 KRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVR 2263
+ G++ +E+ Q +++ +E E E + E E+Q E+ E++E+ ++E++
Sbjct: 290 QTGEQ-EEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMW 348
Query: 2264 EEEEERKEEEEGEEKQVEKEEEEKKKKKKE--KKKEEVQEKEEVFEEKEEIMSEEETESL 2321
++EE+ E+EE Q++K+EE+ +K++++ K++E+++++EE ++EE M E++ +
Sbjct: 349 KQEEQMGEQEE----QMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQM- 403
Query: 2322 SDEEEEEESCSLEEEVDREKEILKKEKQ 2349
E++E+ EE++ +KE ++K+++
Sbjct: 404 --GEQKEQMREQEEQMGEQKEQMRKQEE 429
Score = 107 bits (268), Expect = 1e-22
Identities = 79/475 (16%), Positives = 254/475 (53%), Gaps = 52/475 (10%)
Query: 1597 QEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAE 1656
+E+ QEE QL + E+ Q ++K + R++ + Q+ + Q G+ QE +
Sbjct: 10 KEKNAELQEELQLVETEKSEIQLHIKELK--RKLETDKIPLPQEGQVREQEGQVREQEGQ 67
Query: 1657 KLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQ 1716
+ ++ ++ ++ +V +E ++ ++ G++ E + + ++ ++ ++E + QE ++ +
Sbjct: 68 -VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 126
Query: 1717 ELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEEL 1776
+ ++ ++ +E ++ ++EG++ E++ ++ E+E + Q ++ E+E ++ ++E
Sbjct: 127 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 186
Query: 1777 LIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQK 1836
+ +++ ++ + + +M E+EE++G + EQ+ QK+E + EE + Q+
Sbjct: 187 VREQEGQMGEQEGQMGEQEEQMGEQEEQM--------QKQEEQMGEQEEQMRK-----QE 233
Query: 1837 KNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLT 1896
+ + ++++ + +++E++ +++E + +KQ Q++ + EE++
Sbjct: 234 EQMGEQEEQVQKQEEQVQKQEEQM----------RKQEEQMREQ-----------EEQMR 272
Query: 1897 QEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDI 1956
+++E ++K+KE+ E E++ + E+ + +++E++ ++ E+ M + ++++R
Sbjct: 273 EQEEQMLKQKEQ-TEQEEQTGEQEEQMREQEEQMREQ------EEQMREQEEQMR----- 320
Query: 1957 AKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQEL--FERKLSLEE 2014
++E+ + + +++ E+K ++ E KE + K E ++ +M + E+++ E ++ +E
Sbjct: 321 -EQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQE 379
Query: 2015 KILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKE 2069
+ + ++ + +E ++ + K + + + + ++ + ++ K+ E + ++
Sbjct: 380 EQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQ 434
Score = 103 bits (257), Expect = 2e-21
Identities = 94/465 (20%), Positives = 240/465 (51%), Gaps = 42/465 (9%)
Query: 1850 KEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKL 1909
KEK A+ +E L + + + + ++K KL L Q E +E+E ++++E
Sbjct: 10 KEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQ--EGQVREQEGQVREQEGQ 67
Query: 1910 AETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKR 1969
++ V+ ++ ++QE +E+ E + + + ++R + +E++ R
Sbjct: 68 VREQEGQVREQEGQVREQEGQVREQ-----EGQVREQEGQVREQEGQVREQEG----QVR 118
Query: 1970 LAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEES 2029
E ++R EG+ +G+ E Q + + + E ++ +E + ++ + +E
Sbjct: 119 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 178
Query: 2030 EIAK--GKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDE 2087
++ + G++ GQ +GQ + + ++ ++ E + K+ ++ + + ++K E
Sbjct: 179 QVREQEGQVREQEGQMGEQEGQ--MGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK---QE 233
Query: 2088 RKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLA 2147
++ ++E ++ K + + +E ++ ++ ++ +E E+ ++ K +K+ ++ +
Sbjct: 234 EQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLK-QKEQTEQEEQTG 292
Query: 2148 NKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGD 2207
+ +M +EE+M E+E ++ R+ E + + EE+ G +EE++ ++ W +
Sbjct: 293 EQEEQMREQEEQMREQEEQM-REQEEQMREQEEQMGKQEEQMWEQKEQMWEQ-------- 343
Query: 2208 KPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE 2267
KE+ Q +++ +E E+M+ +++ KQE E+ ++EE+ ++EE++R++EE
Sbjct: 344 --KEQMWKQEEQMGEQE---EQMQKQEEQVRKQE----EQMRKQEEQMRKQEEQMRKQEE 394
Query: 2268 ERKEEEE--GEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKE 2310
+ E++E GE+K+ +E+EE+ ++KE+ + +++E + E+KE
Sbjct: 395 QMGEQKEQMGEQKEQMREQEEQMGEQKEQMR---KQEEHMGEQKE 436
Score = 82.8 bits (203), Expect = 4e-15
Identities = 80/383 (20%), Positives = 190/383 (49%), Gaps = 43/383 (11%)
Query: 2080 LQKLTRDERKLT----QEEIKMTKMKRA---LFVKERRLSIEQSKLDI-KEWDFSEKRSE 2131
+ ++T +E K QEE+++ + +++ L +KE + +E K+ + +E E+ +
Sbjct: 1 MPRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQ 60
Query: 2132 LTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIP 2191
+ + E ++ ++ ++ + ++ +E ++ E+E ++ + +V E+EG + E+E
Sbjct: 61 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV---REQEGQVREQE--- 114
Query: 2192 FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEER 2251
+ R+++ R Q +V +E E E + E E Q + E+
Sbjct: 115 ---GQVREQEGQVR---------EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 162
Query: 2252 EEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEE 2311
E + +E +VRE+E + +E+E G+ ++ E + E++ + E++ E++ E+EE +++EE
Sbjct: 163 EGQVREQEGQVREQEGQVREQE-GQVREQEGQMGEQEGQMGEQE-EQMGEQEEQMQKQEE 220
Query: 2312 IMSEEETESLSDE----EEEEESCSLEEEVDREKEILKK------EKQFKLQEQRRKSLR 2361
M E+E + E E+EE+ EE+V +++E ++K E++ +++EQ + L+
Sbjct: 221 QMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLK 280
Query: 2362 GRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKAT 2421
+E+ + + + ++ +++ +M+E+ +++ WE K+
Sbjct: 281 QKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQM 340
Query: 2422 VVEIPRKFLGTMDKEREVMGKYE 2444
+ + M K+ E MG+ E
Sbjct: 341 WEQKEQ-----MWKQEEQMGEQE 358
Score = 33.1 bits (74), Expect = 4.1
Identities = 29/215 (13%), Positives = 88/215 (40%), Gaps = 22/215 (10%)
Query: 991 QLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQVEQRLNENLTLSHRDEKPAFS 1050
Q+ +++E E ++QM +E +G + +Q QV+++ + + E+
Sbjct: 214 QMQKQEEQMGEQEEQMRKQE---EQMGEQEEQVQKQEEQVQKQEEQ----MRKQEEQMRE 266
Query: 1051 LDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKTKERDSKQ 1110
+ M + + LK +E+ E + + R + +++ ++ ++ +E++ +
Sbjct: 267 QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQM 326
Query: 1111 MSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLK 1170
E + E + W + K + + QE+ + K + +
Sbjct: 327 GKQEEQMWEQKE---------------QMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQ 371
Query: 1171 RLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEE 1205
Q + + + ++++K+ ++ G++ + + E+
Sbjct: 372 EEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQ 406
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 149 bits (377), Expect = 3e-35
Identities = 263/1229 (21%), Positives = 503/1229 (40%), Gaps = 157/1229 (12%)
Query: 1295 KKESKVLLEDLDWDVVPPE--KKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQK 1352
KK S+ LL +D D + +F + G + G+ +E+ E + + + Q
Sbjct: 742 KKASEKLLASIDIDHTQYKFGHTKVFFKAGLL------GLLEEM--RDEKLAQIITRTQA 793
Query: 1353 KARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERK 1412
R L E Q +L++ ++ +F NV + K F K K K+ + E++
Sbjct: 794 VCRGFLMRVEYQKMLQR-REALFCIQYNVRAFMNVKHWPWMKLFFKI-KPLLKSAETEKE 851
Query: 1413 VGKIKREMTKEERDMSEEVEEMATLEEKVV-----KQEGKLVMIERTPSWQDWKKAWDEW 1467
+ +K E K + ++++ + LEEK+V K + +L + S D A +
Sbjct: 852 MATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD---AEERC 908
Query: 1468 KQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKL--------KWE 1519
+Q+ + KE E+ +EE +K E+E + K + K E
Sbjct: 909 EQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 968
Query: 1520 EWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHR 1579
+ K EN + + ++E DE L +E E +Q + + Q EE K + +
Sbjct: 969 KEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQA---EEDKVNILTK 1025
Query: 1580 KRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQ 1639
+ + E++ E L QE++ ER + E L A + + Q + K +
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEK 1085
Query: 1640 KEETLAQRGEKLSQEAE---KLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQK 1696
KE ++ K+ E +L +K K+L + E++ E E K + ++ L+++
Sbjct: 1086 KEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRE 1145
Query: 1697 VEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELN-QEEGKLVEEKKKLAEEEEA 1755
+EE+ +R + + ++ E + ++L EE Q E + +KK A+
Sbjct: 1146 LEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAE 1205
Query: 1756 LAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQK 1815
L Q + L + KL +E+ L E + L+ + E + + + L + L ++ +L K
Sbjct: 1206 LGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTK 1265
Query: 1816 RERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKE----KLAQRKENLLYNKERLTHSK 1871
E + +LT + L + A E EK+ +L++ K+ E L H
Sbjct: 1266 EEEQQRLINDLTAQRARLQTE---AGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQL 1322
Query: 1872 KQLVQVKNKLG-----------------------------MFNKILAQVEEKLTQEKETV 1902
++ + KN L +K ++V + T+ +
Sbjct: 1323 EEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1382
Query: 1903 IKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLA-LEKAMVQGKKRLRGE-----LDI 1956
I++ E+L E +KKL Q L + +E + K A LEK K+RL+ E LD+
Sbjct: 1383 IQRTEELEEAKKKLAQ---RLQEAEEHVEAVNAKCASLEKT----KQRLQNEVEDLMLDV 1435
Query: 1957 AKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKI 2016
+ A K+ L E K+ + + + Q++ + ELF+ K EE +
Sbjct: 1436 ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESL 1495
Query: 2017 -----LLHEDRILAMEESE----IAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLS 2067
L E++ L E S+ IA+G + ++I Q +++ + L + SL
Sbjct: 1496 DQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE 1555
Query: 2068 KEPAKLNKILKALQKLTRD-ERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFS 2126
E K+ +I L ++ + +RK+ +++ ++ ++KR R + QS LD +
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN---HTRVVETMQSTLD------A 1606
Query: 2127 EKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLAR------KHSEVILDDEE 2180
E RS D ++ +K N+M +N ++ E + R K +++ LDD
Sbjct: 1607 EIRSR--NDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDAL 1664
Query: 2181 EGGIEEEEVIPFLKRR-----------WRKRKEAKRGDKPKEKFSSQVDE---------- 2219
G + +E + ++RR W ++ +R K E+ E
Sbjct: 1665 RGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNT 1724
Query: 2220 --VESEEHFSEEMESLLDELEK--QESLSSEEEEERE-------EEEEREEEEVREEEEE 2268
+ +++ ++ L E+E+ QES ++EE+ ++ EE ++E++ E
Sbjct: 1725 SLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1784
Query: 2269 RKEEEEGEEKQVEKEEEEKKK------KKKEKKKEEVQEKEEVFEEKEEIMSEEETESLS 2322
K+ E K ++ +E ++ KK+ +K E + E E E+ + E + L
Sbjct: 1785 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLR 1844
Query: 2323 DEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERV-------LSILRGVPH 2375
E + + + E DR+ + ++ KLQ + + R E LS R + H
Sbjct: 1845 KHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQH 1904
Query: 2376 GKGRA-IRLGVLKSPLKKLMSTALEMKEK 2403
A R + +S + KL + E+ K
Sbjct: 1905 ELEEAEERADIAESQVNKLRVKSREVHTK 1933
Score = 147 bits (370), Expect = 2e-34
Identities = 243/1166 (20%), Positives = 493/1166 (42%), Gaps = 139/1166 (11%)
Query: 1276 MLVDRHPSWELFQEICPLLK-----KESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQ 1330
M V P +LF +I PLLK KE + E+ + K + A R+++ +
Sbjct: 825 MNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQ------KTKDELAKSEAKRKELEE 878
Query: 1331 GVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKK 1390
+ +++ K + + Q Q +A + EE L K K + + VT E ++
Sbjct: 879 KMVT-LLKEKNDL---QLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEE 934
Query: 1391 ------EEKKTFQKSPKQGRKAVQK-ERKVGKIKREMTKEERDMSEEVEEMATLEEKVVK 1443
+K+ + + +K + E + K+++E E + EEMA L+E + K
Sbjct: 935 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 994
Query: 1444 -QEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEE---KLHQA 1499
+ K + E D +A ++ + + + + ++ E L QE++ L +A
Sbjct: 995 LSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERA 1054
Query: 1500 GEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQY---KDEEEVTLEEEVSREGEE 1556
KL + ++ QE + E KQ + L K E K E+E +E ++ ++ +E
Sbjct: 1055 KRKLEGDLKLAQEST-MDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKE 1113
Query: 1557 KEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKL 1616
+ ++ E I+ E RA+AEK+R+ R+L + E+L +E
Sbjct: 1114 LQARIEELGEEIEAERA------SRAKAEKQRSDLSRELEEISERL--------EEAGGA 1159
Query: 1617 AQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREE 1676
A V++ + + A+ + EE Q ++ +K A +L ++ + + R +
Sbjct: 1160 TSAQVELNK--KREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVK 1217
Query: 1677 EKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELN 1736
+KL K+ +L + L+ E + + + NL+ + L ++ EL+ EE +L
Sbjct: 1218 QKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLT 1277
Query: 1737 QEEGKL---VEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKL--------- 1784
+ +L E + +E++AL Q + + T+ +E + ++E+ K
Sbjct: 1278 AQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQ 1337
Query: 1785 -AQH-----KEKMPEEEERLGRKREQLIEKKMKLAQKRERW----INSMEELTKNKMILY 1834
++H +E+ EE+E + L + ++AQ R ++ I EEL + K L
Sbjct: 1338 SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1397
Query: 1835 QKKNLAQEK--------KNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNK 1886
Q+ A+E +L + K++L E+L+ + ER S + K F+K
Sbjct: 1398 QRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER---SNAACAALDKKQRNFDK 1454
Query: 1887 ILAQVEEKLTQ---EKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLA----- 1938
+L++ ++K + E E K+ L+ K+ V + + E L +E L
Sbjct: 1455 VLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISD 1514
Query: 1939 LEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKM 1998
L + + +G K++ EL+ K K++ +EK + + L + E + K+
Sbjct: 1515 LTEQIAEGGKQIH-ELEKIK---------KQVEQEKCEI---QAALEEAEASLEHEEGKI 1561
Query: 1999 TQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRK 2058
+++ EL + K ++ KI ++ I ++ + + + + + + +
Sbjct: 1562 LRIQLELNQVKSEVDRKIAEKDEEI-----DQLKRNHTRVVETMQSTLDAEIRSRNDALR 1616
Query: 2059 LIKKRE-SLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK------------MKRALF 2105
+ KK E L++ +LN + + R+ R TQ +K T+ +K L
Sbjct: 1617 VKKKMEGDLNEMEIQLNHANRLAAESLRNYRN-TQGILKETQLHLDDALRGQEDLKEQLA 1675
Query: 2106 VKERRLSIEQSKLDIKEWDFSE--KRSELTKDEKKLARKQR--KLANKMRRMINKEEKMT 2161
+ ERR ++ Q++++ + W E +RS +++ L +R L + +IN ++K+
Sbjct: 1676 IVERRANLLQAEIE-ELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1734
Query: 2162 EEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVE 2221
+ S+L + EVI + ++ + +KE + + V+
Sbjct: 1735 NDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1794
Query: 2222 SEEHFSEEMESLL-----DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGE 2276
+H +E E L +++K E+ E E E E E++R E V+ RK E +
Sbjct: 1795 DLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVK---GLRKHERRVK 1851
Query: 2277 EKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLS-------DEEEEEE 2329
E + EE+ K + + +++Q K + ++ + E E+ +LS + EE EE
Sbjct: 1852 ELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEE 1911
Query: 2330 SCSLEEEVDREKEILKKEKQFKLQEQ 2355
+ E + + +E K+ +
Sbjct: 1912 RADIAESQVNKLRVKSREVHTKISAE 1937
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A member
6-like protein 6 [Homo sapiens]
Length = 655
Score = 148 bits (374), Expect = 7e-35
Identities = 89/383 (23%), Positives = 214/383 (55%), Gaps = 35/383 (9%)
Query: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSK-EQQYKDEEEVTLEEEVSREGEEKEQ 1559
E+L + LQE +L E ++ N+ K K E+ + L+ E R G+E +
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQS 273
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQA 1619
+ Q ++E W +++++ E+K ++E K+ ++EEK+ ++E ++ ++E K+ +
Sbjct: 274 VSAKLQAQVEENELWNLLNQQQ---EEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQ 330
Query: 1620 YVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKL 1679
K+ + + ++ + E K ++EE + ++ EK+ ++ EK+ ++ +K+ ++ EK+ +EE++
Sbjct: 331 EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEM 390
Query: 1680 AKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEE 1739
++ +K+ E ++ Q W++++ +E +E + EE W++EE
Sbjct: 391 WRQ-----------EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEE----- 434
Query: 1740 GKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLG 1799
K+ E EE + Q EKL E E K+ +EEE + +++EK+ + +EK+ E+EE+
Sbjct: 435 --------KIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTW 486
Query: 1800 RKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKEN 1859
R +E+L++++ K+ ++ E+ E++ + Q++ + ++++ + +++EK+ +++
Sbjct: 487 R-QEKLLKQEEKIWEQEEKMWRQEEKMWE------QEEKMQEQEEKMQRQEEKMREQEVR 539
Query: 1860 LLYNKERLTHSKKQLVQVKNKLG 1882
L +E++ + +L +++ +LG
Sbjct: 540 LWQQEEKMQEQEVRLQELEERLG 562
Score = 143 bits (361), Expect = 2e-33
Identities = 127/473 (26%), Positives = 242/473 (51%), Gaps = 47/473 (9%)
Query: 1909 LAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLR-GELDIAKEEKALNLEM 1967
++ +K +V+ S K+QEK+ ++ K +V K LR GE+ K + LE
Sbjct: 121 VSHVKKNSDEVKSSFKKRQEKMNEKNY--TFRKRVVIKKPWLRLGEVTAQKRPENSLLEE 178
Query: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME 2027
+ +R+ E L+K + + T ++EL E+ L+EK+ R++ E
Sbjct: 179 TLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKL-----RLVESE 233
Query: 2028 ESEIA------KGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSK------EPAKLNK 2075
+SEI K KLE R Q + Q Q L + +L K+ +S+S E +L
Sbjct: 234 KSEIQLNVKDLKRKLE--RAQLLLPQQQ--LQVEADRLGKELQSVSAKLQAQVEENELWN 289
Query: 2076 ILKALQ--KLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELT 2133
+L Q K+ R E K+ ++E KM + + + +E ++ ++ K+ +E E+ ++
Sbjct: 290 LLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMW 349
Query: 2134 KDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFL 2193
+ E+K+ ++ K+ + +M +EEK+ E++ K+ + E+ +E+ EE+
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQ---- 405
Query: 2194 KRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREE 2253
++ WR+ K+ + D EK Q +E+ +E E+E ++ + E E+ E EE
Sbjct: 406 EKMWRQEKKMREQD---EKIREQEEEMWRQEEKIRELEEMMQDQE-------EKLREVEE 455
Query: 2254 EEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIM 2313
+ + EEE+++E+EE+ + + EEK E+EE+ +++K K++E++ E+EE +EE M
Sbjct: 456 KMQEEEEKMQEQEEKIQRQ---EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Query: 2314 SEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERV 2366
E+E + +E+EE +EE RE+E+ +++ K+QEQ + ER+
Sbjct: 513 WEQEEKM----QEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 138 bits (347), Expect = 9e-32
Identities = 120/580 (20%), Positives = 285/580 (49%), Gaps = 40/580 (6%)
Query: 1420 MTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWK 1479
++ E+ D+ + ++ ++ V+ +G E++ + + + + + + R+ K
Sbjct: 25 LSDEDSDLDFHINKLE--QQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTK 82
Query: 1480 AWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWEN---MLSSKSKEQ 1536
W E+ + L+E E Q E L L +D+ ++ V +N + SS K Q
Sbjct: 83 RWDEDDD---LEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQ 139
Query: 1537 QYKDEEEVTLEEEVS------REGE-----EKEQQVTEEQRHIQEEHKWARIHRKRARAE 1585
+ +E+ T + V R GE E + EE H + K +
Sbjct: 140 EKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKER 199
Query: 1586 KKRAQEERKLAQEEEKLA------QEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQ 1639
+ E + +E+L QE+ +L + E+ Q VK + E AQ Q
Sbjct: 200 DAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQ 259
Query: 1640 KEETLAQRGEKLSQEAEKLAQKRKKLAKKW--------EKVAREEEKLAKKGGKLAEVKN 1691
+ + G++L + KL Q + + + W EK+ R+EEK+ ++ K+ E +
Sbjct: 260 LQVEADRLGKELQSVSAKL-QAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQEL 318
Query: 1692 ILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAE 1751
+ ++ E++ ++E+ + QE+++ ++ +++ E++ +EE++ ++E K+ +++K+ E
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 1752 EEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMK 1811
++E + Q E++ +E K+ ++EE + +EK+ + ++KM E++E++ + E++ ++ K
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEE---KRQEKMWRQEKKMREQDEKIREQEEEMWRQEEK 435
Query: 1812 LAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSK 1871
+ + E + E+L + + + +++ QE++ Q +E+ Q +E + +E+L +
Sbjct: 436 IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQE 495
Query: 1872 KQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQ---E 1928
+++ + + K+ + + + EEK+ +++E + +++EK+ E E +L Q E+ + +++ +
Sbjct: 496 EKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQ 555
Query: 1929 KLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMK 1968
+L + KL + ++ G R G + L +E+K
Sbjct: 556 ELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELK 595
Score = 132 bits (333), Expect = 4e-30
Identities = 123/568 (21%), Positives = 265/568 (46%), Gaps = 70/568 (12%)
Query: 1254 ISGSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWD----- 1308
+ S K E +N + TF + +++ + W E+ + E+ +L E L +D
Sbjct: 131 VKSSFKKRQEKMNEKNYTFRKRVVIKK--PWLRLGEVTAQKRPENSLLEETLHFDHAVRM 188
Query: 1309 -------VVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLG-L 1360
+ + + I ++ ++ E+ ++ E+ + Q +D+ L
Sbjct: 189 GTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKL 248
Query: 1361 EETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREM 1420
E Q++L + + + + +GKE+ K Q + + ++++ +M
Sbjct: 249 ERAQLLLPQQQLQVEAD----RLGKELQSVSAKLQAQVEENELWNLLNQQQE-----EKM 299
Query: 1421 TKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKA 1480
++E + E+ E+M E K+ +QE K+ W+ +K ++ +++ + K W+
Sbjct: 300 WRQEEKIQEQEEKMCEQELKIREQEEKM--------WRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 1481 WKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD 1540
E+++ ++EEK+ + EK+ +EE ++E + E+ +++W K +EQ+ K
Sbjct: 352 -----EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQ--EEKIREQEEKR 404
Query: 1541 EEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEE 1600
+E++ +E+ RE +EK ++ QEE W R E+K + E + +EE
Sbjct: 405 QEKMWRQEKKMREQDEKIRE--------QEEEMW--------RQEEKIRELEEMMQDQEE 448
Query: 1601 KLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQ 1660
KL + E ++ +EE K+ + KI + + ++ + E K ++E+ L Q EK+ ++ EK+ +
Sbjct: 449 KLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQE-EKIWEQEEKMWR 507
Query: 1661 KRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEE 1720
+ +K+ ++ EK+ +EEK+ ++ K+ E + L Q+ E++ QE+E+ L+E
Sbjct: 508 QEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKM---------QEQEV--RLQE 556
Query: 1721 LEWDMEELSWKEEEL---NQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELL 1777
LE + +L K E L +E G + E + + + L +++ +
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQY 616
Query: 1778 IQEKEKLAQHKEKMPEEEERLGRKREQL 1805
+ ++LA KE +P R R + L
Sbjct: 617 VAAYQQLASGKEALPSCSSRKLRAKRWL 644
Score = 115 bits (288), Expect = 6e-25
Identities = 125/566 (22%), Positives = 272/566 (48%), Gaps = 63/566 (11%)
Query: 1554 GEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEE 1613
G+ +E+ + +E K+ ++ A E ++ + ++ ++++ E+ + +E
Sbjct: 51 GKPREKSIADE--------KFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKES 102
Query: 1614 RKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVA 1673
K V T D E + G +K S E + +KR++ +
Sbjct: 103 LKR----VTFTLPDDEAIEDAG---------VSHVKKNSDEVKSSFKKRQEKMNEKNYTF 149
Query: 1674 REEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQE--------KELAQELEELEWDM 1725
R+ + K +L EV AQK E E+ L + ++L +E + ++
Sbjct: 150 RKRVVIKKPWLRLGEVT---AQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLEL 206
Query: 1726 EELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLA 1785
+ +EEL ++ +L +EK +L E E++ E +L ++ E+ +L
Sbjct: 207 YRNTITDEELKEKNAEL-QEKLRLVESEKS-----------EIQLNVKDLKRKLERAQLL 254
Query: 1786 QHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKN 1845
++++ E +RLG++ + + K ++ E W N + + + KM ++K QE+K
Sbjct: 255 LPQQQLQVEADRLGKELQSVSAKLQAQVEENELW-NLLNQQQEEKMWRQEEKIQEQEEKM 313
Query: 1846 LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKK 1905
QE K+ +++E + +E++ ++++ + ++K+ + + + EEK+ +++E + ++
Sbjct: 314 CEQEL-KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQ 372
Query: 1906 KEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNL 1965
+EK+ E ++K+ + E+ + +++EK+ +++ K EK Q KK + I ++E+
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEK-RQEKMWRQEKKMREQDEKIREQEE---- 427
Query: 1966 EMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILA 2025
EM R EEK+R +E E + E + KM + E+++ E+ EEKI E++I
Sbjct: 428 EMWR-QEEKIRELE--EMMQDQEEKLREVEEKMQEEEEKMQEQ----EEKIQRQEEKIQE 480
Query: 2026 MEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTR 2085
EE + KL + ++I+ Q + K+ + K+ ++ E + ++ K+ + +K+
Sbjct: 481 QEEKTWRQEKL-LKQEEKIWEQ-EEKMWRQEEKMWEQEEKMQEQEEKMQ---RQEEKMRE 535
Query: 2086 DERKLTQEEIKMTKMKRALFVKERRL 2111
E +L Q+E KM + + L E RL
Sbjct: 536 QEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 107 bits (268), Expect = 1e-22
Identities = 133/599 (22%), Positives = 286/599 (47%), Gaps = 95/599 (15%)
Query: 1926 KQEKLAQEK------MKLALEKAMVQGKKRLRGELDIAKEE--KALNLEMKRL------- 1970
+++ +A EK M+ LE +G KR + D+ + E K +KR+
Sbjct: 54 REKSIADEKFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDD 113
Query: 1971 -AEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEES 2029
A E + K+ + ++ RQ KM + +R + + + L E E+
Sbjct: 114 EAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPEN 173
Query: 2030 EIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERK 2089
+ + L F R + KL K+R++ S E + N I K E +
Sbjct: 174 SLLEETLHFDHAVR--------MGTYIEKLTKERDAPSLELYR-NTITDEELKEKNAELQ 224
Query: 2090 LTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLA-- 2147
++ K + L VK+ + +E+++L + + + L K+ + ++ K +
Sbjct: 225 EKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEE 284
Query: 2148 NKMRRMINK--EEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKR 2205
N++ ++N+ EEKM +E K+ + ++ E+E I E+E ++ WR+ ++
Sbjct: 285 NELWNLLNQQQEEKMWRQEEKIQEQEEKMC---EQELKIREQE-----EKMWRQEEKMH- 335
Query: 2206 GDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEE--------- 2256
+ +EK Q D++ +E E E +++ +QE +EE+ E++E
Sbjct: 336 --EQEEKIREQEDKMWRQEEKIREQE---EKIREQEEKMWRQEEKIREQDEKIQEQEEEM 390
Query: 2257 -REEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKE--KKKEEVQEKEEVFEEKEEIM 2313
R+EE++RE+EE+R+E+ +EK++ +++E+ +++++E +++E+++E EE+ +++EE +
Sbjct: 391 WRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKL 450
Query: 2314 SE------EETESLSDEEE-----EEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRG 2362
E EE E + ++EE EE+ EE+ R++++LK+E+ K+ EQ K R
Sbjct: 451 REVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEE--KIWEQEEKMWRQ 508
Query: 2363 RERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKATV 2422
E++ + ++ +K+ +M+E+ V + +++ ++++ +
Sbjct: 509 EEKMWE-------------QEEKMQEQEEKMQRQEEKMREQ-EVRLWQQEEKMQEQEVRL 554
Query: 2423 VEIPRKFLGTMDKEREVMGKYEPIPPHVLGTVLESQAQDLKTPFMSHILRRTVEAEELQ 2481
E+ + LG + ++ E++G G ES +Q L P ++ IL+ ++++E Q
Sbjct: 555 QELEER-LGKLGQKAELLG----------GAGRESGSQRL--PTLTPILQVELKSQEAQ 600
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A member
6-like protein 6 [Homo sapiens]
Length = 655
Score = 148 bits (374), Expect = 7e-35
Identities = 89/383 (23%), Positives = 214/383 (55%), Gaps = 35/383 (9%)
Query: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSK-EQQYKDEEEVTLEEEVSREGEEKEQ 1559
E+L + LQE +L E ++ N+ K K E+ + L+ E R G+E +
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQS 273
Query: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQA 1619
+ Q ++E W +++++ E+K ++E K+ ++EEK+ ++E ++ ++E K+ +
Sbjct: 274 VSAKLQAQVEENELWNLLNQQQ---EEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQ 330
Query: 1620 YVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKL 1679
K+ + + ++ + E K ++EE + ++ EK+ ++ EK+ ++ +K+ ++ EK+ +EE++
Sbjct: 331 EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEM 390
Query: 1680 AKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEE 1739
++ +K+ E ++ Q W++++ +E +E + EE W++EE
Sbjct: 391 WRQ-----------EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEE----- 434
Query: 1740 GKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLG 1799
K+ E EE + Q EKL E E K+ +EEE + +++EK+ + +EK+ E+EE+
Sbjct: 435 --------KIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTW 486
Query: 1800 RKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKEN 1859
R +E+L++++ K+ ++ E+ E++ + Q++ + ++++ + +++EK+ +++
Sbjct: 487 R-QEKLLKQEEKIWEQEEKMWRQEEKMWE------QEEKMQEQEEKMQRQEEKMREQEVR 539
Query: 1860 LLYNKERLTHSKKQLVQVKNKLG 1882
L +E++ + +L +++ +LG
Sbjct: 540 LWQQEEKMQEQEVRLQELEERLG 562
Score = 142 bits (359), Expect = 4e-33
Identities = 127/473 (26%), Positives = 242/473 (51%), Gaps = 47/473 (9%)
Query: 1909 LAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLR-GELDIAKEEKALNLEM 1967
++ +K +V+ S K+QEK+ ++ K +V K LR GE+ K + LE
Sbjct: 121 VSHVKKNSDEVKSSFKKRQEKMNEKNY--TFRKRVVIKKPWLRLGEVTAQKRPENSLLEE 178
Query: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAME 2027
+ +R+ E L+K + + T ++EL E+ L+EK+ R++ E
Sbjct: 179 TLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAELQEKL-----RLVESE 233
Query: 2028 ESEIA------KGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSK------EPAKLNK 2075
+SEI K KLE R Q + Q Q L + +L K+ +S+S E +L
Sbjct: 234 KSEIQLNVKDLKRKLE--RAQLLLPQQQ--LQVEADRLGKELQSVSAKLQAQVEENELWN 289
Query: 2076 ILKALQ--KLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELT 2133
+L Q K+ R E K+ ++E KM + + + +E ++ ++ K+ +E E+ ++
Sbjct: 290 LLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMW 349
Query: 2134 KDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFL 2193
+ E+K+ ++ K+ + +M +EEK+ E++ K+ + E+ +E+ EE+
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQ---- 405
Query: 2194 KRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREE 2253
++ WR+ K+ + D EK Q +E+ +E E+E ++ + E E+ E EE
Sbjct: 406 EKMWRQEKKMREQD---EKIREQEEEMWRQEEKIRELEEMMQDQE-------EKLREVEE 455
Query: 2254 EEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIM 2313
+ + EEE+++E+EE+ + + EEK E+EE+ +++K K++E++ E+EE +EE M
Sbjct: 456 KMQEEEEKMQEQEEKIQRQ---EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Query: 2314 SEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERV 2366
E+E + +E+EE +EE RE+E+ +++ K+QEQ + ER+
Sbjct: 513 WEQEEKM----QEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 138 bits (347), Expect = 9e-32
Identities = 120/580 (20%), Positives = 285/580 (49%), Gaps = 40/580 (6%)
Query: 1420 MTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWK 1479
++ E+ D+ + ++ ++ V+ +G E++ + + + + + + R+ K
Sbjct: 25 LSDEDSDLDFHINKLE--QQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTK 82
Query: 1480 AWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWEN---MLSSKSKEQ 1536
W E+ + L+E E Q E L L +D+ ++ V +N + SS K Q
Sbjct: 83 RWDEDDD---LEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQ 139
Query: 1537 QYKDEEEVTLEEEVS------REGE-----EKEQQVTEEQRHIQEEHKWARIHRKRARAE 1585
+ +E+ T + V R GE E + EE H + K +
Sbjct: 140 EKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKER 199
Query: 1586 KKRAQEERKLAQEEEKLA------QEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQ 1639
+ E + +E+L QE+ +L + E+ Q VK + E AQ Q
Sbjct: 200 DALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQ 259
Query: 1640 KEETLAQRGEKLSQEAEKLAQKRKKLAKKW--------EKVAREEEKLAKKGGKLAEVKN 1691
+ + G++L + KL Q + + + W EK+ R+EEK+ ++ K+ E +
Sbjct: 260 LQVEADRLGKELQSVSAKL-QAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQEL 318
Query: 1692 ILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAE 1751
+ ++ E++ ++E+ + QE+++ ++ +++ E++ +EE++ ++E K+ +++K+ E
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 1752 EEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMK 1811
++E + Q E++ +E K+ ++EE + +EK+ + ++KM E++E++ + E++ ++ K
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEE---KRQEKMWRQEKKMREQDEKIREQEEEMWRQEEK 435
Query: 1812 LAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSK 1871
+ + E + E+L + + + +++ QE++ Q +E+ Q +E + +E+L +
Sbjct: 436 IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQE 495
Query: 1872 KQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQ---E 1928
+++ + + K+ + + + EEK+ +++E + +++EK+ E E +L Q E+ + +++ +
Sbjct: 496 EKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQ 555
Query: 1929 KLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMK 1968
+L + KL + ++ G R G + L +E+K
Sbjct: 556 ELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELK 595
Score = 133 bits (334), Expect = 3e-30
Identities = 124/568 (21%), Positives = 268/568 (47%), Gaps = 70/568 (12%)
Query: 1254 ISGSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWD----- 1308
+ S K E +N + TF + +++ + W E+ + E+ +L E L +D
Sbjct: 131 VKSSFKKRQEKMNEKNYTFRKRVVIKK--PWLRLGEVTAQKRPENSLLEETLHFDHAVRM 188
Query: 1309 -----VVPPEKKPIFIQ--EGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLG-L 1360
+ E+ + ++ I ++ ++ E+ ++ E+ + Q +D+ L
Sbjct: 189 GTYIEKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKL 248
Query: 1361 EETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREM 1420
E Q++L + + + + +GKE+ K Q + + ++++ +M
Sbjct: 249 ERAQLLLPQQQLQVEAD----RLGKELQSVSAKLQAQVEENELWNLLNQQQE-----EKM 299
Query: 1421 TKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKA 1480
++E + E+ E+M E K+ +QE K+ W+ +K ++ +++ + K W+
Sbjct: 300 WRQEEKIQEQEEKMCEQELKIREQEEKM--------WRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 1481 WKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKD 1540
E+++ ++EEK+ + EK+ +EE ++E + E+ +++W K +EQ+ K
Sbjct: 352 -----EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQ--EEKIREQEEKR 404
Query: 1541 EEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEE 1600
+E++ +E+ RE +EK ++ QEE W R E+K + E + +EE
Sbjct: 405 QEKMWRQEKKMREQDEKIRE--------QEEEMW--------RQEEKIRELEEMMQDQEE 448
Query: 1601 KLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQ 1660
KL + E ++ +EE K+ + KI + + ++ + E K ++E+ L Q EK+ ++ EK+ +
Sbjct: 449 KLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQE-EKIWEQEEKMWR 507
Query: 1661 KRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEE 1720
+ +K+ ++ EK+ +EEK+ ++ K+ E + L Q+ E++ QE+E+ L+E
Sbjct: 508 QEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKM---------QEQEV--RLQE 556
Query: 1721 LEWDMEELSWKEEEL---NQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELL 1777
LE + +L K E L +E G + E + + + L +++ +
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQY 616
Query: 1778 IQEKEKLAQHKEKMPEEEERLGRKREQL 1805
+ ++LA KE +P R R + L
Sbjct: 617 VAAYQQLASGKEALPSCSSRKLRAKRWL 644
Score = 118 bits (295), Expect = 1e-25
Identities = 126/566 (22%), Positives = 273/566 (48%), Gaps = 63/566 (11%)
Query: 1554 GEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEE 1613
G+ +E+ + +E K+ ++ A E ++ + ++ ++++ E+ + +E
Sbjct: 51 GKPREKSIADE--------KFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKES 102
Query: 1614 RKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVA 1673
K V T D E + G +K S E + +KR++ +
Sbjct: 103 LKR----VTFTLPDDEAIEDAG---------VSHVKKNSDEVKSSFKKRQEKMNEKNYTF 149
Query: 1674 REEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQE--------KELAQELEELEWDM 1725
R+ + K +L EV AQK E E+ L + ++L +E + L ++
Sbjct: 150 RKRVVIKKPWLRLGEVT---AQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLEL 206
Query: 1726 EELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLA 1785
+ +EEL ++ +L +EK +L E E++ E +L ++ E+ +L
Sbjct: 207 YRNTITDEELKEKNAEL-QEKLRLVESEKS-----------EIQLNVKDLKRKLERAQLL 254
Query: 1786 QHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKN 1845
++++ E +RLG++ + + K ++ E W N + + + KM ++K QE+K
Sbjct: 255 LPQQQLQVEADRLGKELQSVSAKLQAQVEENELW-NLLNQQQEEKMWRQEEKIQEQEEKM 313
Query: 1846 LAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKK 1905
QE K+ +++E + +E++ ++++ + ++K+ + + + EEK+ +++E + ++
Sbjct: 314 CEQEL-KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQ 372
Query: 1906 KEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNL 1965
+EK+ E ++K+ + E+ + +++EK+ +++ K EK Q KK + I ++E+
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEK-RQEKMWRQEKKMREQDEKIREQEE---- 427
Query: 1966 EMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILA 2025
EM R EEK+R +E E + E + KM + E+++ E+ EEKI E++I
Sbjct: 428 EMWR-QEEKIRELE--EMMQDQEEKLREVEEKMQEEEEKMQEQ----EEKIQRQEEKIQE 480
Query: 2026 MEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTR 2085
EE + KL + ++I+ Q + K+ + K+ ++ E + ++ K+ + +K+
Sbjct: 481 QEEKTWRQEKL-LKQEEKIWEQ-EEKMWRQEEKMWEQEEKMQEQEEKMQ---RQEEKMRE 535
Query: 2086 DERKLTQEEIKMTKMKRALFVKERRL 2111
E +L Q+E KM + + L E RL
Sbjct: 536 QEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 110 bits (275), Expect = 2e-23
Identities = 134/599 (22%), Positives = 287/599 (47%), Gaps = 95/599 (15%)
Query: 1926 KQEKLAQEK------MKLALEKAMVQGKKRLRGELDIAKEE--KALNLEMKRL------- 1970
+++ +A EK M+ LE +G KR + D+ + E K +KR+
Sbjct: 54 REKSIADEKFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDD 113
Query: 1971 -AEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEES 2029
A E + K+ + ++ RQ KM + +R + + + L E E+
Sbjct: 114 EAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPEN 173
Query: 2030 EIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERK 2089
+ + L F R + KL K+R++LS E + N I K E +
Sbjct: 174 SLLEETLHFDHAVR--------MGTYIEKLTKERDALSLELYR-NTITDEELKEKNAELQ 224
Query: 2090 LTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLA-- 2147
++ K + L VK+ + +E+++L + + + L K+ + ++ K +
Sbjct: 225 EKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEE 284
Query: 2148 NKMRRMINK--EEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKR 2205
N++ ++N+ EEKM +E K+ + ++ E+E I E+E ++ WR+ ++
Sbjct: 285 NELWNLLNQQQEEKMWRQEEKIQEQEEKMC---EQELKIREQE-----EKMWRQEEKMH- 335
Query: 2206 GDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEE--------- 2256
+ +EK Q D++ +E E E +++ +QE +EE+ E++E
Sbjct: 336 --EQEEKIREQEDKMWRQEEKIREQE---EKIREQEEKMWRQEEKIREQDEKIQEQEEEM 390
Query: 2257 -REEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKE--KKKEEVQEKEEVFEEKEEIM 2313
R+EE++RE+EE+R+E+ +EK++ +++E+ +++++E +++E+++E EE+ +++EE +
Sbjct: 391 WRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKL 450
Query: 2314 SE------EETESLSDEEE-----EEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRG 2362
E EE E + ++EE EE+ EE+ R++++LK+E+ K+ EQ K R
Sbjct: 451 REVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEE--KIWEQEEKMWRQ 508
Query: 2363 RERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKATV 2422
E++ + ++ +K+ +M+E+ V + +++ ++++ +
Sbjct: 509 EEKMWE-------------QEEKMQEQEEKMQRQEEKMREQ-EVRLWQQEEKMQEQEVRL 554
Query: 2423 VEIPRKFLGTMDKEREVMGKYEPIPPHVLGTVLESQAQDLKTPFMSHILRRTVEAEELQ 2481
E+ + LG + ++ E++G G ES +Q L P ++ IL+ ++++E Q
Sbjct: 555 QELEER-LGKLGQKAELLG----------GAGRESGSQRL--PTLTPILQVELKSQEAQ 600
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 147 bits (371), Expect = 1e-34
Identities = 232/1113 (20%), Positives = 482/1113 (43%), Gaps = 150/1113 (13%)
Query: 1412 KVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVH 1471
K + ++EM + D EE+A E + + E K+V + + + D QV
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKN--------DLQLQVQ 896
Query: 1472 GETRKSWKAWK--EEWEKRLLQEEEKLHQAGEKLSPEEEMLQE---------DKKLKWEE 1520
ET A + E K + E K+ + E+L EEEM E DK +
Sbjct: 897 SETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKR 956
Query: 1521 WKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEH-------- 1572
E L+ KE+ + + L EE++ EE ++T+E++ +QE H
Sbjct: 957 DIDDLELTLTKVEKEKHATENKVKNLSEEMTAL-EENISKLTKEKKSLQEAHQQTLDDLQ 1015
Query: 1573 ----KWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDR 1628
K + + A+ E++ E L QE++ A ER + E L + I +
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEN 1075
Query: 1629 EMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKG---GK 1685
+ Q E K +KE L+Q K+ E Q +KK+ + ++ EE++ + K
Sbjct: 1076 DKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAK 1135
Query: 1686 LAEVKNILAQKVEELPQREQNLDW-------QEKELAQELEELEWDMEELSWKEE----- 1733
+ + ++ LA+++EE+ +R + K+ E +++ D+EE + + E
Sbjct: 1136 IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1195
Query: 1734 -----------------ELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEEL 1776
L + + KL +EK +L E + +A E LS+ ++ + +
Sbjct: 1196 LRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRT 1255
Query: 1777 LIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQK 1836
+ + ++ E+ + L ++ +L + +L+ + E + + +LTK+K L Q+
Sbjct: 1256 VEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQ 1315
Query: 1837 -KNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGM-FNKILAQVEEK 1894
+ L ++ + + K +A ++ ++ + L ++ + K +L +K ++V +
Sbjct: 1316 LEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQW 1375
Query: 1895 LTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLA-LEKAMVQGKKRLRGE 1953
T+ + I++ E+L E +KKL Q L + +E K A LEK K+RL+GE
Sbjct: 1376 RTKYETDAIQRTEELEEAKKKLAQ---RLQEAEENTETANSKCASLEKT----KQRLQGE 1428
Query: 1954 L-----DIAKEEKAL-NLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFE 2007
+ D+ + A L+ K+ +K+ L E K+ L + + + Q++ + ELF+
Sbjct: 1429 VEDLMRDLERSHTACATLDKKQRNFDKV-LAEWKQKLDESQAELEAAQKESRSLSTELFK 1487
Query: 2008 RKLSLEEKI-----LLHEDRILAMEESEIA-------KGKLEFTRGQRIFVQGQRKLAKA 2055
+ + EE + L E++ L E S++ K E + +++ Q + L A
Sbjct: 1488 MRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVA 1547
Query: 2056 SRKLIKKRESLSKEPAKLNKILKALQKLTRD-ERKLTQEEIKMTKMKRALFVKERRLSIE 2114
++ SL E +K+ ++ L ++ + +RK+ +++ ++ ++KR +R
Sbjct: 1548 LEEV---EGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRN---SQRAAEAL 1601
Query: 2115 QSKLDIK--------------EWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKM 2160
QS LD + E D +E +L +++A Q+ L ++ + + +
Sbjct: 1602 QSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHL 1661
Query: 2161 TE---------EESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKE 2211
+ E+ + + + ++L++ EE + E+ RR +++ D+ +
Sbjct: 1662 DDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTER--TRRLSEQELLDASDRVQL 1719
Query: 2212 KFSSQVDEVESEEHFSEEMESLLDELEK--QESLSSEEEEERE-------EEEEREEEEV 2262
S + +++ ++ E+E QES ++EE+ ++ EE ++E++
Sbjct: 1720 LHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1779
Query: 2263 REEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEE---TE 2319
E K+ E K ++ +E ++ + K+++Q+ E E E + E+ E
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAE 1839
Query: 2320 SLSDE---EEEEESCSLEEEVDREKEILKKEK-----QFKLQEQRRKSLRGRERV---LS 2368
+L E + + + + E D K IL+ + Q K++ +R++ E+ LS
Sbjct: 1840 ALKGAHKYERKVKEMTYQAEED-HKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLS 1898
Query: 2369 ILRGVPHG-KGRAIRLGVLKSPLKKLMSTALEM 2400
R V H + A R + +S + KL + + ++
Sbjct: 1899 RCRRVQHELEEAAERADIAESQVNKLRAKSRDV 1931
Score = 145 bits (365), Expect = 7e-34
Identities = 248/1151 (21%), Positives = 480/1151 (41%), Gaps = 129/1151 (11%)
Query: 1276 MLVDRHPSWELFQEICPLLK-----KESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQ 1330
M V P LF +I PLLK KE + ED + K + A R+++ +
Sbjct: 826 MNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDFE------RTKEELARSEARRKELEE 879
Query: 1331 GVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKK 1390
+ + ++ + Q Q + +++ EE L K K I LE + + + ++
Sbjct: 880 KMVSLLQEKNDL----QLQVQSETENLMDAEERCEGLIKSK--ILLEAKVKELTERLEEE 933
Query: 1391 EEKKTFQKSPKQG---------RKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKV 1441
EE + + K+ R E + K+++E E + EEM LEE +
Sbjct: 934 EEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENI 993
Query: 1442 VK--QEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEK---- 1495
K +E K + + D + D+ V+G + + K ++ + E+EK
Sbjct: 994 SKLTKEKKSLQEAHQQTLDDLQVEEDK---VNGLIKINAKLEQQTDDLEGSLEQEKKLRA 1050
Query: 1496 -LHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQ---QYKDEEEVTLEEEVS 1551
L +A KL + +M QE + E KQ E L K E Q K ++E +
Sbjct: 1051 DLERAKRKLEGDLKMSQESI-MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQ 1109
Query: 1552 REGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQ 1611
++ +E + ++ E + I+ EH RA+ EK+R+ R+L + E+L
Sbjct: 1110 KKIKELQARIEELEEEIEAEHTL------RAKIEKQRSDLARELEEISERL--------- 1154
Query: 1612 EERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEK 1671
E +I + + A+ + EE Q + +K A +L ++ +
Sbjct: 1155 -EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN 1213
Query: 1672 VAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWK 1731
+ R ++KL K+ +L + +A +E L + + N++ + + + E++ E+ +
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 1732 EEELNQEEGKL----------VEEKK----KLAEEEEALAWQREKLS---EEETKLAQEE 1774
+LN ++ +L VEEK+ +L + ++AL Q E+L EEETK
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAM 1333
Query: 1775 ELLIQ-EKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW----INSMEELTKN 1829
+Q + +E+ EE+E + L + ++AQ R ++ I EEL +
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 1830 KMILYQKKNLAQEKKNLAQEK----EKLAQRKENLLYNKER-LTHSKKQLVQVKNKLGMF 1884
K L Q+ A+E A K EK QR + + + R L S + K F
Sbjct: 1394 KKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNF 1453
Query: 1885 NKILAQVEEKLTQ---EKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEK 1941
+K+LA+ ++KL + E E K+ L+ K+ + + + E L +E L E
Sbjct: 1454 DKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEI 1513
Query: 1942 AMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQV 2001
+ + + G+ ++ + EK L + ++ ++ L E + +L E+ Q +++QV
Sbjct: 1514 SDLTEQIAETGK-NLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQV 1572
Query: 2002 EQELFERKLSLEEKI----------------LLHED--------RILAMEESEIAKGKLE 2037
+ EL + + +E+I +L + R+ E ++ + +++
Sbjct: 1573 KSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQ 1632
Query: 2038 FTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKM 2097
R + Q+ L +L K + + + N+ LK + L EE++
Sbjct: 1633 LGHSNRQMAETQKHLRTVQGQL-KDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEE 1691
Query: 2098 TKMKRALFVKERRLSIEQSKLDIKE--WDFSEKRSELTKDEKKL----ARKQRKLANKMR 2151
K+ + RRLS EQ LD + + + L +KKL A+ Q ++ N ++
Sbjct: 1692 MKVALEQTERTRRLS-EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQ 1750
Query: 2152 RMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE-----EEVIPFLKRRWRKRKE--AK 2204
N EEK + + A E+ + + +E E+ + L+ R + ++ K
Sbjct: 1751 ESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1810
Query: 2205 RGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVRE 2264
G K +K ++V E+E+E E + + L+ + +E + EE + +R
Sbjct: 1811 GGKKQIQKLENRVRELENE--LDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRL 1868
Query: 2265 EEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDE 2324
++ K + + + + + EE E++ + + VQ + E E+ +I +E + L +
Sbjct: 1869 QDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADI-AESQVNKLRAK 1927
Query: 2325 EEEEESCSLEE 2335
+ S +EE
Sbjct: 1928 SRDVGSQKMEE 1938
Score = 66.2 bits (160), Expect = 4e-10
Identities = 164/910 (18%), Positives = 373/910 (40%), Gaps = 109/910 (11%)
Query: 961 QGLMDKDERVRIKTLSLMAEIG---IHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLG 1017
Q + +K ++ + L A+I +HS ++ + Q E+++++ E L +
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIE 1137
Query: 1018 MRATDLQILSTQVEQRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIK 1077
+ +DL ++ +RL E + + + +++ L+ T+ E+ A
Sbjct: 1138 KQRSDLARELEEISERLEEASGATSAQIEMNKKREAEF-QKMRRDLEEATLQHEATAAT- 1195
Query: 1078 PSKGQRRGQAGVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVY 1137
R+ QA + + L++ K++ LE E I+ +++
Sbjct: 1196 ----LRKKQADSVAELGEQIDNLQRVKQK-----------LEKEKSELKMEIDDMASNIE 1240
Query: 1138 SQWSSSTSVIKLSKDVDSQEKDI-SKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKG 1196
+ S +++ + + V+ Q +I +KD ++ Q I D +KA Q + +
Sbjct: 1241 ALSKSKSNIERTCRTVEDQFSEIKAKDE-----QQTQLIHDLNMQKARLQTQNGELSHRV 1295
Query: 1197 KEAKVINEETTPPVMEQPVTKKV-KIQGRGASGISGRRSTAGDGSSWRDDLCRLMALRIS 1255
+E + + + T +Q +T+++ +++ + + + A S R D C L+ +
Sbjct: 1296 EEKESLISQLTK--SKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHD-CDLLREQYE 1352
Query: 1256 GSQTKMSE------NLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDV 1309
Q +E N+E+ + + D E +E KK+ L++ + +
Sbjct: 1353 EEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE----AKKKLAQRLQEAEENT 1408
Query: 1310 VPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKK 1369
K +++ + +QG ++++R E KK R+ +L +
Sbjct: 1409 ETANSKCASLEK---TKQRLQGEVEDLMRDLERSHTACATLDKKQRNF------DKVLAE 1459
Query: 1370 GKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSE 1429
K+ + + E ++KE + + K + ++ ++RE + ++S+
Sbjct: 1460 WKQKLDESQAEL----EAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISD 1515
Query: 1430 EVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWK-QVHGETRKSWKAW------K 1482
E++A + + + E ++E+ S D + A +E + + E K + K
Sbjct: 1516 LTEQIAETGKNLQEAEKTKKLVEQEKS--DLQVALEEVEGSLEHEESKILRVQLELSQVK 1573
Query: 1483 EEWEKRLLQEEEKLHQAGEKLSPEEEMLQE---------------DKKLKWE-------- 1519
E ++++++++E++ Q E LQ KK++ +
Sbjct: 1574 SELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQL 1633
Query: 1520 --EWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRH--IQEEHKWA 1575
+Q+ E ++ + Q KD ++ L++ + + KEQ E+R+ + EE +
Sbjct: 1634 GHSNRQMAETQKHLRTVQGQLKD-SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692
Query: 1576 RIHRKRARAEKKRAQEERKLAQEEEKLAQEER-QLAQEERKL----AQAYVKITQDDREM 1630
++ ++ ++ +++E A + +L + L ++KL AQ ++ +E
Sbjct: 1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES 1752
Query: 1631 AQAEGKFAQKEETLAQRGEKLSQE------AEKLAQKRKKLAKKWEKVAREEEKLAKKGG 1684
AE K + A E+L +E E++ + ++ K + E E+LA KGG
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812
Query: 1685 KLAEVKNILAQKVEELPQREQNLDWQEKELAQELE---ELEWDMEELSWKEEELNQEEGK 1741
K K L +V EL E LD ++K A+ L+ + E ++E++++ EE ++ +
Sbjct: 1813 KKQIQK--LENRVREL---ENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILR 1867
Query: 1742 LVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRK 1801
L + KL + ++ Q E+ E+ + E E+ A+ + + +L K
Sbjct: 1868 LQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAK 1927
Query: 1802 REQLIEKKMK 1811
+ +KM+
Sbjct: 1928 SRDVGSQKME 1937
Score = 43.9 bits (102), Expect = 0.002
Identities = 57/271 (21%), Positives = 119/271 (43%), Gaps = 39/271 (14%)
Query: 2228 EEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEE-E 2286
+EM ++ ++ E+ + + E R+E EE+ ++E+ + + + + E ++ EE E
Sbjct: 851 KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCE 910
Query: 2287 KKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCS-LEEEVDR-EKEIL 2344
K K + +V+E E EE+EE+ SE ++ + E+ CS L+ ++D E +
Sbjct: 911 GLIKSKILLEAKVKELTERLEEEEEMNSE----LVAKKRNLEDKCSSLKRDIDDLELTLT 966
Query: 2345 KKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKT 2404
K EK+ E + K+L + + L+ + KL ++E
Sbjct: 967 KVEKEKHATENKVKNL-------------------SEEMTALEENISKLTKEKKSLQEAH 1007
Query: 2405 PVPVPEKQISWEDKKATVVEIPRK-------FLGTMDKEREVMGKYEPIPPHVLGTVLES 2457
+ + Q+ EDK +++I K G++++E+++ E + G + S
Sbjct: 1008 QQTLDDLQVE-EDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMS 1066
Query: 2458 Q-----AQDLKTPFMSHILRRTVEAEELQHK 2483
Q ++ K + ++ E +LQ K
Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAK 1097
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 114,447,228
Number of Sequences: 37866
Number of extensions: 6073214
Number of successful extensions: 235886
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2017
Number of HSP's successfully gapped in prelim test: 1532
Number of HSP's that attempted gapping in prelim test: 31364
Number of HSP's gapped (non-prelim): 56302
length of query: 2873
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2753
effective length of database: 13,703,598
effective search space: 37726005294
effective search space used: 37726005294
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.