Guide to the Human Genome
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Search of human proteins with 221136914

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
         (686 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1389   0.0  
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]   1331   0.0  
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea...  1326   0.0  
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea...  1323   0.0  
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1294   0.0  
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1293   0.0  
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do...  1286   0.0  
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat...   984   0.0  
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]               815   0.0  
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]               573   e-163
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]              566   e-161
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]           465   e-131
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]         457   e-128
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,...   347   2e-95
gi|239755288 PREDICTED: cyclin Y-like 2 [Homo sapiens]                169   6e-42
gi|239749780 PREDICTED: cyclin Y-like 2 [Homo sapiens]                169   6e-42
gi|239744040 PREDICTED: cyclin Y-like 2 [Homo sapiens]                169   6e-42
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma...   141   2e-33
gi|187608516 centaurin, beta 2 [Homo sapiens]                         127   3e-29
gi|7661880 centaurin beta1 [Homo sapiens]                             126   8e-29
gi|46094081 development and differentiation enhancing factor 1 [...   124   4e-28
gi|206725422 G protein-coupled receptor kinase interacting ArfGA...   117   5e-26
gi|206725420 G protein-coupled receptor kinase interacting ArfGA...   117   5e-26
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP...   117   5e-26
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP...   117   5e-26
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP...   117   5e-26
gi|206725415 G protein-coupled receptor kinase interacting ArfGA...   117   5e-26
gi|146231998 G protein-coupled receptor kinase interactor 1 isof...   115   2e-25
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo...   115   2e-25
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai...   114   4e-25

>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 5 [Homo sapiens]
          Length = 686

 Score = 1389 bits (3594), Expect = 0.0
 Identities = 686/686 (100%), Positives = 686/686 (100%)

Query: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120
           DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120

Query: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180

Query: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240

Query: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360
           KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540
           DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA
Sbjct: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540

Query: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600
           NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL
Sbjct: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600

Query: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 661 LTYARQASSQECINVLLQYGCPDECV 686


>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
          Length = 686

 Score = 1331 bits (3444), Expect = 0.0
 Identities = 660/686 (96%), Positives = 668/686 (97%)

Query: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC VHPSVSLEFDQQQGSVCPSESE YEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120
           DLHMHH+RD+EMPEALEF+LSANPE+STIFQRNSQT+ALEFNPSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120

Query: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVS  RFSQQYS CSTIFLDDSTA QHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180

Query: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DR+LSIPDEQLHSFAVSTVHI K RNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240

Query: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGS PDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360
           KKKYVTLCSNG+LTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PISSSKS
Sbjct: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540
           D ETQNPKWASLNLGVLMCIECSGIHRSLG  LSRVRSLELDDWPVELRKVMSSI NDLA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540

Query: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600
           NSIWEGSSQGQTKPS KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ LLRATADEDL
Sbjct: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600

Query: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGS EEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 661 LTYARQASSQECINVLLQYGCPDECV 686


>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
           and PH domain 9 [Homo sapiens]
          Length = 684

 Score = 1326 bits (3431), Expect = 0.0
 Identities = 661/686 (96%), Positives = 667/686 (97%), Gaps = 2/686 (0%)

Query: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC VHPSVSLEFDQQQGSVCPSESEIYEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120
           DLHMH +RD+EMPEALEF+LSANPEASTIFQRNSQTDALEFN SANPEASTIFQRNSQTD
Sbjct: 61  DLHMHQVRDREMPEALEFNLSANPEASTIFQRNSQTDALEFNSSANPEASTIFQRNSQTD 120

Query: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTA QHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180

Query: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DRSLSIPDEQLHSFAVSTVHI K RNGGGSLNNYSSSIP TPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTP 240

Query: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGS PDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360
           KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSP ISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPGISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSC+SSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540
           D ETQNPKWASLNLGVLMCIECSGIHRS GTRLSRVRSLELDDWPVELRKVMSSIGN+LA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELA 540

Query: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600
           NSIWEGSSQGQTKPS+KSTREEKE WIRSKYEEKLFLAPLPCTELSLGQ LLRAT DEDL
Sbjct: 541 NSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDL 600

Query: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL QLL   GVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTA 658

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 659 LTYARQASSQECINVLLQYGCPDECV 684


>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
           and PH domain 10 [Homo sapiens]
          Length = 684

 Score = 1323 bits (3424), Expect = 0.0
 Identities = 660/686 (96%), Positives = 666/686 (97%), Gaps = 2/686 (0%)

Query: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC VHPSVSLEFDQQQGSVCPSESEIYEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120
           DLHMH +RD+EMPEALEF+LSANPEASTIFQRNSQTDALEFN SANPEASTIFQRNSQTD
Sbjct: 61  DLHMHQVRDREMPEALEFNLSANPEASTIFQRNSQTDALEFNSSANPEASTIFQRNSQTD 120

Query: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTA QHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180

Query: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DRSLSIPDEQLHSFAVSTVHI K RNGGGSLNNYSSSIP TPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTP 240

Query: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCK SMRWSNLFTSEKGS PDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKLSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300

Query: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360
           KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSP ISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPGISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSC+SSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480

Query: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540
           D ETQNPKWASLNLGVLMCIECSGIHRS GTRLSRVRSLELDDWPVELRKVMSSIGN+LA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELA 540

Query: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600
           NSIWEGSSQGQTKPS+KSTREEKE WIRSKYEEKLFLAPLPCTELSLGQ LLRAT DEDL
Sbjct: 541 NSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDL 600

Query: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL QLL   GVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTA 658

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 659 LTYARQASSQECINVLLQYGCPDECV 684


>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 4 [Homo sapiens]
          Length = 663

 Score = 1294 bits (3349), Expect = 0.0
 Identities = 646/686 (94%), Positives = 652/686 (95%), Gaps = 23/686 (3%)

Query: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC VHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120
           DLHMHH+RD+EMPEALEF                       NPSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHVRDREMPEALEF-----------------------NPSANPEASTIFQRNSQTD 97

Query: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVST RFSQQYS CSTIFLDDSTA QHYLTMTIISVTLEIPHHITQRDA
Sbjct: 98  VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157

Query: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DRSLSIPDEQLHSFAVSTVHI K RNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217

Query: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGS PDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277

Query: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360
           KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PIS+SKS
Sbjct: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKS 337

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS+AMALQSIQNMRGNAHCV
Sbjct: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCV 457

Query: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540
           D ETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA
Sbjct: 458 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517

Query: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600
           NSIWEGSSQGQTKPS KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ LLRATADEDL
Sbjct: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 577

Query: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPD+CV
Sbjct: 638 LTYARQASSQECINVLLQYGCPDKCV 663


>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 8 [Homo sapiens]
          Length = 663

 Score = 1293 bits (3347), Expect = 0.0
 Identities = 647/686 (94%), Positives = 650/686 (94%), Gaps = 23/686 (3%)

Query: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC VHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120
           DLHMHH+RD+EMPEALEF                       NPSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHVRDREMPEALEF-----------------------NPSANPEASTIFQRNSQTD 97

Query: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVST RFSQQYS CSTIFLDDSTA QHYLTMTIISVTLEIPHHITQRDA
Sbjct: 98  VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157

Query: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DRSLSIPDEQLHSFAVSTVHI K RNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217

Query: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGS PDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277

Query: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360
           KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PISSSKS
Sbjct: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 337

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 457

Query: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540
           D ETQNPKWASLNLGVLMCIECSGIH SLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA
Sbjct: 458 DCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517

Query: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600
           NSIWEGSSQGQTKPS KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ LL ATADEDL
Sbjct: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDL 577

Query: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 638 LTYARQASSQECINVLLQYGCPDECV 663


>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 7 [Homo sapiens]
          Length = 663

 Score = 1286 bits (3327), Expect = 0.0
 Identities = 643/686 (93%), Positives = 649/686 (94%), Gaps = 23/686 (3%)

Query: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTC VHPSVSLEFDQQQGSVCPSESEIYEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1   MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60

Query: 61  DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120
           DLHMHH+RD+EMPEALEF                       NPSANPEASTIFQRNSQTD
Sbjct: 61  DLHMHHVRDREMPEALEF-----------------------NPSANPEASTIFQRNSQTD 97

Query: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180
           VVEIRRSNCTNHVST  FSQQYS CSTIFLDDSTA QHYLTMTIISVTLEIPHHITQRDA
Sbjct: 98  VVEIRRSNCTNHVSTVHFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157

Query: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 158 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217

Query: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
           TPVCKRSMRWSNLFTSEKGS PDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277

Query: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360
           KKKYVTLCSNGVLTYYSSLGDYMK IHKKEIDL+TSTIKVPGKWPSLAT AC PISSSKS
Sbjct: 278 KKKYVTLCSNGVLTYYSSLGDYMKYIHKKEIDLQTSTIKVPGKWPSLATLACTPISSSKS 337

Query: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
           +GLSKDMDTGLGDSICFSPSISSTT PKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 338 DGLSKDMDTGLGDSICFSPSISSTTIPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397

Query: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
           WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 457

Query: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540
           D ETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA
Sbjct: 458 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517

Query: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600
           NSIWEGSSQG+TKP+ KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ LLRATADEDL
Sbjct: 518 NSIWEGSSQGRTKPTEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 577

Query: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
           QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637

Query: 661 LTYARQASSQECINVLLQYGCPDECV 686
           LTYARQASSQECINVLLQYGCPDECV
Sbjct: 638 LTYARQASSQECINVLLQYGCPDECV 663


>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
           protein 11 [Homo sapiens]
          Length = 550

 Score =  984 bits (2543), Expect = 0.0
 Identities = 497/550 (90%), Positives = 508/550 (92%), Gaps = 25/550 (4%)

Query: 162 MTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPST 221
           MTIISVTLEI HHIT+RDADRSL+I DEQL+SFA STVHITK RNGGGSLNNYSSSIP T
Sbjct: 1   MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60

Query: 222 PSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRA 281
           PSTSQED  FSVPPTANTPTP+CK+SM WSNLFTSEKGS PDK RKA E+HADTIGSGRA
Sbjct: 61  PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120

Query: 282 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 341
           IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP
Sbjct: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180

Query: 342 GKWPSLATSACAPISSSKSNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPP 392
           GKWPSLATSACAPISSSKSNGLSKDM         D GLGDSICFSPSISSTTSPKLN P
Sbjct: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240

Query: 393 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 436
           PSPHANKKKHLKKKSTNN                FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300

Query: 437 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLGV 496
           AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGN+HCVD ETQNPKWASLNLGV
Sbjct: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360

Query: 497 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSV 556
           LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPS+
Sbjct: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420

Query: 557 KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSREEVN 616
           +STREEKERWIRSKYE KLFLAPLPCTELSLGQHLLRATADEDL+TAILLLAHGSREEVN
Sbjct: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480

Query: 617 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 676
           ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540

Query: 677 LQYGCPDECV 686
           LQYGCPDECV
Sbjct: 541 LQYGCPDECV 550


>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
          Length = 804

 Score =  815 bits (2106), Expect = 0.0
 Identities = 415/532 (78%), Positives = 456/532 (85%), Gaps = 32/532 (6%)

Query: 185 SIPDEQLHSFA----VSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           S+P+   HS      VS VHI++  NGGGSL++YSSS+PSTPSTSQ++ +  VPPTANTP
Sbjct: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304

Query: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 299
           TPV K+S R SNLFTS KGS PDKE+K  E+ AD+IGSGRAIPIKQGMLLKRSGK L K 
Sbjct: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364

Query: 300 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSK 359
           WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL  +T+KVPGK P  ATSACAPISS K
Sbjct: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424

Query: 360 SNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNN 410
           +NGLSKDM         DTGLGDS+C SPSISSTTSPKL+PPPSPHAN+KKH +KKST+N
Sbjct: 425 TNGLSKDMSSLHISPNSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSN 484

Query: 411 F------------------MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESS 452
           F                  +IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESS
Sbjct: 485 FKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESS 544

Query: 453 KSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTR 512
           K+KS+LTSQSEAMALQSI+NMRGN+HCVD ETQNP WASLNLG LMCIECSGIHR+LGT 
Sbjct: 545 KNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTH 604

Query: 513 LSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERWIRSKYE 572
           LSRVRSL+LDDWPVEL KVMSSIGN+LANS+WE SSQG+TKPSV STREEKERWIR+KYE
Sbjct: 605 LSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYE 664

Query: 573 EKLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLAC 632
           +KLFLAPLPCTELSLGQHLLRATADEDL+TAILLLAHGSR+EVNETCGEGDG TALHLAC
Sbjct: 665 QKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLAC 724

Query: 633 RKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
           RKGNVVLAQLLIWYGVDV ARDAHGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 725 RKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 776


>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
          Length = 857

 Score =  573 bits (1478), Expect = e-163
 Identities = 289/369 (78%), Positives = 315/369 (85%), Gaps = 28/369 (7%)

Query: 334 RTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMDTGLGDSICFSPSISSTTSPKLNPPP 393
           R+ ++    +W      A + ISS          DTGLGDS+C SPSISSTTSPKL+PPP
Sbjct: 471 RSYSVSSADQWSEATVIANSAISS----------DTGLGDSVCSSPSISSTTSPKLDPPP 520

Query: 394 SPHANKKKHLKKKSTNNF------------------MIVSATGQTWHFEATTYEERDAWV 435
           SPHAN+KKH +KKST+NF                  +IVS TGQTWHFEATTYEERDAWV
Sbjct: 521 SPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWV 580

Query: 436 QAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLG 495
           QAI+SQILASLQSCESSK+KS+LTSQSEAMALQSI+NMRGN+HCVD ETQNP WASLNLG
Sbjct: 581 QAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLG 640

Query: 496 VLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPS 555
            LMCIECSGIHR+LGT LSRVRSL+LDDWPVEL KVMSSIGN+LANS+WE SSQG+TKPS
Sbjct: 641 ALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPS 700

Query: 556 VKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSREEV 615
           V STREEKERWIR+KYE+KLFLAPLPCTELSLGQHLLRATADEDL+TAILLLAHGSR+EV
Sbjct: 701 VDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEV 760

Query: 616 NETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINV 675
           NETCGEGDG TALHLACRKGNVVLAQLLIWYGVDV ARDAHGNTAL YARQASSQECI+V
Sbjct: 761 NETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDV 820

Query: 676 LLQYGCPDE 684
           LLQYGCPDE
Sbjct: 821 LLQYGCPDE 829



 Score =  258 bits (659), Expect = 1e-68
 Identities = 137/207 (66%), Positives = 160/207 (77%), Gaps = 10/207 (4%)

Query: 185 SIPDEQLHSFA----VSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
           S+P+   HS      VS VHI++  NGGGSL++YSSS+PSTPSTSQ++ +  VPPTANTP
Sbjct: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304

Query: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 299
           TPV K+S R SNLFTS KGS PDKE+K  E+ AD+IGSGRAIPIKQGMLLKRSGK L K 
Sbjct: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364

Query: 300 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSK 359
           WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL  +T+KVPGK P  ATSACAPISS K
Sbjct: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424

Query: 360 SNGLSKDMDTGLGDSICFSPSISSTTS 386
           +NGLSKDM      S+  SP+  + TS
Sbjct: 425 TNGLSKDM-----SSLHISPNSGNVTS 446


>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
          Length = 911

 Score =  566 bits (1459), Expect = e-161
 Identities = 304/582 (52%), Positives = 387/582 (66%), Gaps = 82/582 (14%)

Query: 185 SIPDEQLHSF----AVSTVHITKNRNGGGS-LNNYSSSIPSTPSTSQEDPQFSVPPTANT 239
           S+P+   HS     ++  VHI +  NGGGS  ++YSSS+PSTPS SQ + +      ++T
Sbjct: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360

Query: 240 PTPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 298
           PTP+ K+S R SN+FTS KG+  D+E+KA E   D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420

Query: 299 TWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAP---- 354
            WKKKYVTLC NG+LTY+ SL DYM+NIH KEIDL  +T+KVPGK    AT A AP    
Sbjct: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480

Query: 355 ----ISSSKSN--------------GLSKDMDTGLGDSICFSP----------SISS--- 383
               +S  +SN                S   +  L  S    P          S+SS   
Sbjct: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540

Query: 384 -----------------------TTSPKLNPPPSPHANKKKHLKKKSTNN---------- 410
                                  ++SPKL+PPPSPH+N+KKH +KKST            
Sbjct: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600

Query: 411 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS 462
                   F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+
Sbjct: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660

Query: 463 EAMALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD 522
            A+A+Q+++ +RGN+ C+D +  NP WASLNLG LMCIECSGIHR LG  LSRVRSL+LD
Sbjct: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720

Query: 523 DWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPC 582
           DWP EL  VM+++GN LANS+WEG+  G +KP   + REEKERWIR+KYE+KLFLAPLP 
Sbjct: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780

Query: 583 TELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQL 642
           +++ LGQ LLRA  ++DL+  ++LLAHGS+EEVNET G+GDG TALHL+    NVV  QL
Sbjct: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840

Query: 643 LIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
           LIWYGVDV +RDA G T L YAR+A SQEC ++L+Q+GCP E
Sbjct: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGE 882


>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
          Length = 836

 Score =  465 bits (1197), Expect = e-131
 Identities = 264/557 (47%), Positives = 344/557 (61%), Gaps = 63/557 (11%)

Query: 185 SIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 242
           S+P    HS A + V      + GG  ++YSSS+PS+P+    + +      A   TP  
Sbjct: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302

Query: 243 VCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
           + + + R ++LF + +GS  D E+++ ++  +T GSGRAIPIKQ  LLKRSG  L K WK
Sbjct: 303 LHRAAKRRTSLFANRRGS--DSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360

Query: 302 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSN 361
           KKYVTL SNG L Y+ S+ DY+ + H KE+DL  +T+KVPGK P  A SA  P  S+  N
Sbjct: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418

Query: 362 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 387
           GL KDM T  +G+ +         SPS SS   P                          
Sbjct: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478

Query: 388 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 427
                    PPPSP   K++  K              ++    F+IVS+TGQTWHFEA +
Sbjct: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538

Query: 428 YEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNP 487
           +EERDAWVQAI+SQILASLQ CESSK K +  SQSEA+A+Q+I+N +GN+ CVD    NP
Sbjct: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598

Query: 488 KWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS 547
            WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP EL  V+++IGND AN +WE  
Sbjct: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658

Query: 548 SQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLL 607
           ++G+ KPS  S+REE+E WIR+KYE+ LFLAPL  +E  LG+ L  A   +D+ T +LLL
Sbjct: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718

Query: 608 AHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQA 667
           AH     ++ +  +    + LHLA    +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778

Query: 668 SSQECINVLLQYGCPDE 684
            SQ C ++LLQ+GCP E
Sbjct: 779 GSQLCADILLQHGCPGE 795


>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
          Length = 1192

 Score =  457 bits (1176), Expect = e-128
 Identities = 264/577 (45%), Positives = 344/577 (59%), Gaps = 83/577 (14%)

Query: 185  SIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 242
            S+P    HS A + V      + GG  ++YSSS+PS+P+    + +      A   TP  
Sbjct: 581  SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638

Query: 243  VCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
            + + + R ++LF + +GS  D E+++ ++  +T GSGRAIPIKQ  LLKRSG  L K WK
Sbjct: 639  LHRAAKRRTSLFANRRGS--DSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696

Query: 302  KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSN 361
            KKYVTL SNG L Y+ S+ DY+ + H KE+DL  +T+KVPGK P  A SA  P  S+  N
Sbjct: 697  KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754

Query: 362  GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 387
            GL KDM T  +G+ +         SPS SS   P                          
Sbjct: 755  GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814

Query: 388  ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 410
                     PPPSP   K++  K  + +                                
Sbjct: 815  GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874

Query: 411  ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMAL 467
               F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ CESSK K +  SQSEA+A+
Sbjct: 875  NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934

Query: 468  QSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVE 527
            Q+I+N +GN+ CVD    NP WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP E
Sbjct: 935  QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994

Query: 528  LRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSL 587
            L  V+++IGND AN +WE  ++G+ KPS  S+REE+E WIR+KYE+ LFLAPL  +E  L
Sbjct: 995  LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054

Query: 588  GQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 647
            G+ L  A   +D+ T +LLLAH     ++ +  +    + LHLA    +VV+ QLL+WYG
Sbjct: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114

Query: 648  VDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
             DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 1151


>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
           member 1 [Homo sapiens]
          Length = 284

 Score =  347 bits (890), Expect = 2e-95
 Identities = 170/173 (98%), Positives = 171/173 (98%)

Query: 514 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERWIRSKYEE 573
           SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPS KSTREEKERWIRSKYEE
Sbjct: 112 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE 171

Query: 574 KLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR 633
           KLFLAPLPCT+LSLGQ LLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR
Sbjct: 172 KLFLAPLPCTDLSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR 231

Query: 634 KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV 686
           KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV
Sbjct: 232 KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV 284



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 18/18 (100%), Positives = 18/18 (100%)

Query: 178 RDADRSLSIPDEQLHSFA 195
           RDADRSLSIPDEQLHSFA
Sbjct: 94  RDADRSLSIPDEQLHSFA 111


>gi|239755288 PREDICTED: cyclin Y-like 2 [Homo sapiens]
          Length = 362

 Score =  169 bits (429), Expect = 6e-42
 Identities = 105/200 (52%), Positives = 121/200 (60%), Gaps = 28/200 (14%)

Query: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCCV P  S    Q QG VC  ESEIYEA AGD +AG P+AAAV+P EVT   GE
Sbjct: 1   MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60

Query: 61  DLHMHHIRDQEMPE--ALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQ 118
            LHMHHI ++EMPE   LE + S +P+ASTIF R SQTD                     
Sbjct: 61  GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTD--------------------- 99

Query: 119 TDVVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISV--TLEIPHHIT 176
              V+ ++      VSTE F+QQYSSCSTIFLDDS ASQ +LTMT+ S      I  +  
Sbjct: 100 ---VQEKKKKQLCKVSTEHFTQQYSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQA 156

Query: 177 QRDADRSLSIPDEQLHSFAV 196
           +RDA RSL I DEQLH   V
Sbjct: 157 KRDAHRSLGIFDEQLHPLTV 176


>gi|239749780 PREDICTED: cyclin Y-like 2 [Homo sapiens]
          Length = 362

 Score =  169 bits (429), Expect = 6e-42
 Identities = 105/200 (52%), Positives = 121/200 (60%), Gaps = 28/200 (14%)

Query: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCCV P  S    Q QG VC  ESEIYEA AGD +AG P+AAAV+P EVT   GE
Sbjct: 1   MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60

Query: 61  DLHMHHIRDQEMPE--ALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQ 118
            LHMHHI ++EMPE   LE + S +P+ASTIF R SQTD                     
Sbjct: 61  GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTD--------------------- 99

Query: 119 TDVVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISV--TLEIPHHIT 176
              V+ ++      VSTE F+QQYSSCSTIFLDDS ASQ +LTMT+ S      I  +  
Sbjct: 100 ---VQEKKKKQLCKVSTEHFTQQYSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQA 156

Query: 177 QRDADRSLSIPDEQLHSFAV 196
           +RDA RSL I DEQLH   V
Sbjct: 157 KRDAHRSLGIFDEQLHPLTV 176


>gi|239744040 PREDICTED: cyclin Y-like 2 [Homo sapiens]
          Length = 362

 Score =  169 bits (429), Expect = 6e-42
 Identities = 105/200 (52%), Positives = 121/200 (60%), Gaps = 28/200 (14%)

Query: 1   MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
           MGNILTCCV P  S    Q QG VC  ESEIYEA AGD +AG P+AAAV+P EVT   GE
Sbjct: 1   MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60

Query: 61  DLHMHHIRDQEMPE--ALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQ 118
            LHMHHI ++EMPE   LE + S +P+ASTIF R SQTD                     
Sbjct: 61  GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTD--------------------- 99

Query: 119 TDVVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISV--TLEIPHHIT 176
              V+ ++      VSTE F+QQYSSCSTIFLDDS ASQ +LTMT+ S      I  +  
Sbjct: 100 ---VQEKKKKQLCKVSTEHFTQQYSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQA 156

Query: 177 QRDADRSLSIPDEQLHSFAV 196
           +RDA RSL I DEQLH   V
Sbjct: 157 KRDAHRSLGIFDEQLHPLTV 176


>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
           3 [Homo sapiens]
          Length = 834

 Score =  141 bits (355), Expect = 2e-33
 Identities = 80/192 (41%), Positives = 113/192 (58%), Gaps = 22/192 (11%)

Query: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCES-------SKSKSQLT 459
           F ++S T ++   +A + + R AWVQA+Q+ I ++ +    SC S       S S S + 
Sbjct: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390

Query: 460 SQSEAM--------ALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGT 511
           S ++           LQ +Q++ GN+ C D    +P+WAS+NLGVL+CIECSGIHRSLG 
Sbjct: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450

Query: 512 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQ--GQTKPSVKSTREEKERWIRS 569
             S+VRSL LD W  EL K+M  +GN   N I+E   +  G  KP+  S+R++KE WI+ 
Sbjct: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510

Query: 570 KYEEKLFLAPLP 581
           KY EK FL   P
Sbjct: 511 KYVEKKFLRKAP 522



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)

Query: 584 ELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLL 643
           EL  G    RA    DL      LAHG+  EVN    E +G T L  A   G++++ + L
Sbjct: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722

Query: 644 IWYGVDVMARDAHGNTALTYA 664
           +  G DV  RD+ G   L +A
Sbjct: 723 LQNGADVNQRDSRGRAPLHHA 743


>gi|187608516 centaurin, beta 2 [Homo sapiens]
          Length = 778

 Score =  127 bits (320), Expect = 3e-29
 Identities = 75/186 (40%), Positives = 109/186 (58%), Gaps = 21/186 (11%)

Query: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 461
           F +VS T ++   +A + + R AW++A+Q+ I  + +           +SS S   L S 
Sbjct: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388

Query: 462 SEAM--------ALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRL 513
           +E+         ALQ +Q + GNA C D    +P+WAS+NLG+ +CIECSGIHRSLG   
Sbjct: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448

Query: 514 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSVKSTREEKERWIRSKY 571
           S+VRSL LD W  EL K+M  +GND+ N ++E +    G  KP     R+EKE +IR+KY
Sbjct: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQ-PGQRQEKEAYIRAKY 507

Query: 572 EEKLFL 577
            E+ F+
Sbjct: 508 VERKFV 513



 Score = 36.6 bits (83), Expect = 0.079
 Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 2/85 (2%)

Query: 580 LPCTELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL 639
           L    L+ G  L RA+ +++L      LAHG+  +VN    E +  T L  A   G++V 
Sbjct: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656

Query: 640 AQLLIWYGVDVMARDAHGNTALTYA 664
            + L+  G +V  RD  G   L +A
Sbjct: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681


>gi|7661880 centaurin beta1 [Homo sapiens]
          Length = 740

 Score =  126 bits (316), Expect = 8e-29
 Identities = 123/428 (28%), Positives = 173/428 (40%), Gaps = 94/428 (21%)

Query: 284 IKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGK 343
           + +G L KR+    KTW +++ T+ SN  L Y     D +  +     DLR  T+K+   
Sbjct: 267 VMEGHLFKRASNAFKTWSRRWFTIQSN-QLVYQKKYKDPVTVVVD---DLRLCTVKL--- 319

Query: 344 WPSLATSAC-APISSSKSNGLSKDMD--TGLGDSICFSPSISSTTSPKLNPPPSPHANKK 400
            P      C   +S+SKS  L  D +    L  S   S   S+ +  +L+  P       
Sbjct: 320 CPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGS 379

Query: 401 KHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTS 460
            HL                                 AI S   A+L S   ++ +     
Sbjct: 380 GHL---------------------------------AIGS--AATLGSGGMARGRE---P 401

Query: 461 QSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLE 520
                 +  +Q++ GNA C D     P+WAS+NLGV +CI+CSGIHRSLG   S+VRSL 
Sbjct: 402 GGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLT 461

Query: 521 LDDWPVELRKVMSSIGNDLANSIWEGSSQGQT--KPSVKSTREEKERWIRSKYEEKLFLA 578
           LD W  EL K+M  +GN + N I+E   +     KP    +R+EKE WI +KY EK FL 
Sbjct: 462 LDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLT 521

Query: 579 PLP-----------------------------------------CTELSLGQHLLRATA- 596
            LP                                            L  G  L RA+  
Sbjct: 522 KLPEIRGRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLGSLHPGALLFRASGH 581

Query: 597 DEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAH 656
              L T    LAHG+  +VN   G  D  T L  A    +++  + L+  G +V   D+ 
Sbjct: 582 PPSLPTMADALAHGA--DVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSA 639

Query: 657 GNTALTYA 664
           G   L +A
Sbjct: 640 GRGPLHHA 647



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 27/86 (31%), Positives = 43/86 (50%), Gaps = 4/86 (4%)

Query: 591 LLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDV 650
           L++ATA   L     LL +G+     ++ G G     LH A   G+  LA L +  G D+
Sbjct: 611 LIQATAANSLLACEFLLQNGANVNQADSAGRGP----LHHATILGHTGLACLFLKRGADL 666

Query: 651 MARDAHGNTALTYARQASSQECINVL 676
            ARD+ G   LT A + ++ + + +L
Sbjct: 667 GARDSEGRDPLTIAMETANADIVTLL 692


>gi|46094081 development and differentiation enhancing factor 1
           [Homo sapiens]
          Length = 1129

 Score =  124 bits (310), Expect = 4e-28
 Identities = 91/293 (31%), Positives = 142/293 (48%), Gaps = 20/293 (6%)

Query: 395 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCES 451
           P+A  KK     S N         +T+HF+A   ++  AW+  +   + + L      E 
Sbjct: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427

Query: 452 SKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGT 511
           S  ++ L   ++A+ ++ +Q + GN  C D  +  P W S NLG+L CIECSGIHR +G 
Sbjct: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486

Query: 512 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQT-KPSVKSTREEKERWIRSK 570
            +SR++SLELD        +  ++GN+  N I E +    + KP+  S    ++ +I +K
Sbjct: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546

Query: 571 YEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSR--EEVNETCGEGDGCTAL 628
           Y +  F      T  +    LL A    DL   I + A G    E + E  G+  G TAL
Sbjct: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605

Query: 629 HLACR---KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
           HLA R   + ++ L   L+    ++  + A GNT L Y    S  EC+ +LL+
Sbjct: 606 HLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658


>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 5 [Homo sapiens]
          Length = 729

 Score =  117 bits (292), Expect = 5e-26
 Identities = 72/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)

Query: 471 QNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 530
           + +R +  C D    +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIGNDLANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC 582
           ++ ++ N+ ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122

Query: 583 ------TELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636
                 T   L + L  +    +L+T + LL+ G++           G T LH+A + G 
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179

Query: 637 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
           ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 6 [Homo sapiens]
          Length = 681

 Score =  117 bits (292), Expect = 5e-26
 Identities = 72/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)

Query: 471 QNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 530
           + +R +  C D    +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIGNDLANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC 582
           ++ ++ N+ ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122

Query: 583 ------TELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636
                 T   L + L  +    +L+T + LL+ G++           G T LH+A + G 
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179

Query: 637 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
           ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 3 [Homo sapiens]
          Length = 679

 Score =  117 bits (292), Expect = 5e-26
 Identities = 72/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)

Query: 471 QNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 530
           + +R +  C D    +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIGNDLANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC 582
           ++ ++ N+ ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122

Query: 583 ------TELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636
                 T   L + L  +    +L+T + LL+ G++           G T LH+A + G 
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179

Query: 637 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
           ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 1 [Homo sapiens]
          Length = 759

 Score =  117 bits (292), Expect = 5e-26
 Identities = 72/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)

Query: 471 QNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 530
           + +R +  C D    +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIGNDLANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC 582
           ++ ++ N+ ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122

Query: 583 ------TELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636
                 T   L + L  +    +L+T + LL+ G++           G T LH+A + G 
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179

Query: 637 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
           ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 2 [Homo sapiens]
          Length = 631

 Score =  117 bits (292), Expect = 5e-26
 Identities = 72/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)

Query: 471 QNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 530
           + +R +  C D    +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIGNDLANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC 582
           ++ ++ N+ ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122

Query: 583 ------TELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636
                 T   L + L  +    +L+T + LL+ G++           G T LH+A + G 
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179

Query: 637 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
           ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 4 [Homo sapiens]
          Length = 471

 Score =  117 bits (292), Expect = 5e-26
 Identities = 72/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)

Query: 471 QNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 530
           + +R +  C D    +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62

Query: 531 VMSSIGNDLANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC 582
           ++ ++ N+ ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC
Sbjct: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122

Query: 583 ------TELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636
                 T   L + L  +    +L+T + LL+ G++           G T LH+A + G 
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179

Query: 637 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
           ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221


>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
           1 [Homo sapiens]
          Length = 770

 Score =  115 bits (287), Expect = 2e-25
 Identities = 71/214 (33%), Positives = 110/214 (51%), Gaps = 17/214 (7%)

Query: 479 CVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 538
           C D    +P WAS++ GVL+C EC  +HRSLG  +S V+ L    WP  L +++ ++ ++
Sbjct: 11  CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70

Query: 539 LANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC------TE 584
            ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC      T 
Sbjct: 71  GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130

Query: 585 LSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 644
             L + L  +    +L+T + LL+ G++           G T LH+A + G  + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187

Query: 645 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
            YG D  + D +G T + YARQA   E    L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221


>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
           2 [Homo sapiens]
          Length = 761

 Score =  115 bits (287), Expect = 2e-25
 Identities = 71/214 (33%), Positives = 110/214 (51%), Gaps = 17/214 (7%)

Query: 479 CVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 538
           C D    +P WAS++ GVL+C EC  +HRSLG  +S V+ L    WP  L +++ ++ ++
Sbjct: 11  CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70

Query: 539 LANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC------TE 584
            ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC      T 
Sbjct: 71  GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130

Query: 585 LSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 644
             L + L  +    +L+T + LL+ G++           G T LH+A + G  + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187

Query: 645 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
            YG D  + D +G T + YARQA   E    L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221


>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
           isoform b [Homo sapiens]
          Length = 894

 Score =  114 bits (284), Expect = 4e-25
 Identities = 88/279 (31%), Positives = 133/279 (47%), Gaps = 24/279 (8%)

Query: 419 QTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEA-----------MAL 467
           +T+HF+A    E +AWV  +Q+    +L S    +  +   S   A           + +
Sbjct: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420

Query: 468 QSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD-DWPV 526
             +++  GN+ C D    +P W S NLGVL CI+CSG+HR LG R SR++SL LD   P 
Sbjct: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480

Query: 527 ELRKVMSSIGNDLANSIWEGS--SQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTE 584
           EL   + ++GN   N + E    S G  KPS +S    +  +I +KY E  F     CT 
Sbjct: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537

Query: 585 LSLGQHLLRATADEDLQTAILLLAHGS--REEVNETCGEGDGCTALHLACRKGN---VVL 639
               Q L  A  + DL + +   A+G    + +     +      LHLA +  N   + L
Sbjct: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595

Query: 640 AQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
              +I  G  + A+ A GNTAL YA   +  +C+ +LL+
Sbjct: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.126    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,894,951
Number of Sequences: 37866
Number of extensions: 1228312
Number of successful extensions: 5724
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 339
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 4128
Number of HSP's gapped (non-prelim): 1496
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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