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Search of human proteins with 11496279
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11496279 male germ cell-associated kinase [Homo sapiens]
(623 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11496279 male germ cell-associated kinase [Homo sapiens] 1274 0.0
gi|27477122 intestinal cell kinase [Homo sapiens] 666 0.0
gi|7662388 intestinal cell kinase [Homo sapiens] 666 0.0
gi|7657498 MAPK/MAK/MRK overlapping kinase [Homo sapiens] 226 5e-59
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 222 9e-58
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 220 3e-57
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 220 3e-57
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 219 5e-57
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 216 5e-56
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 203 4e-52
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 203 4e-52
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 203 4e-52
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens] 201 2e-51
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 197 2e-50
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 197 2e-50
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 196 5e-50
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 196 5e-50
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 193 5e-49
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens] 191 1e-48
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 191 2e-48
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 189 5e-48
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 189 5e-48
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 189 9e-48
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 189 9e-48
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 189 9e-48
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 189 9e-48
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 189 9e-48
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 189 9e-48
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 187 3e-47
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 185 9e-47
>gi|11496279 male germ cell-associated kinase [Homo sapiens]
Length = 623
Score = 1274 bits (3296), Expect = 0.0
Identities = 623/623 (100%), Positives = 623/623 (100%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA
Sbjct: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
Query: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG
Sbjct: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
Query: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSP 180
FFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSP
Sbjct: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSP 180
Query: 181 IDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQ 240
IDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQ
Sbjct: 181 IDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQ 240
Query: 241 CVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESK 300
CVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESK
Sbjct: 241 CVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESK 300
Query: 301 QSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPK 360
QSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPK
Sbjct: 301 QSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPK 360
Query: 361 QQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHS 420
QQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHS
Sbjct: 361 QQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHS 420
Query: 421 KKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTSLKSDSELSTAPTSKQYY 480
KKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTSLKSDSELSTAPTSKQYY
Sbjct: 421 KKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTSLKSDSELSTAPTSKQYY 480
Query: 481 LKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPKSLGPVGAELAFKRSNAGNLGSYAT 540
LKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPKSLGPVGAELAFKRSNAGNLGSYAT
Sbjct: 481 LKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPKSLGPVGAELAFKRSNAGNLGSYAT 540
Query: 541 YNQSGYIPSFLKKEVQSAGQRIHLAPLNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIV 600
YNQSGYIPSFLKKEVQSAGQRIHLAPLNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIV
Sbjct: 541 YNQSGYIPSFLKKEVQSAGQRIHLAPLNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIV 600
Query: 601 NRAQPIPSVHGRTDWVAKYGGHR 623
NRAQPIPSVHGRTDWVAKYGGHR
Sbjct: 601 NRAQPIPSVHGRTDWVAKYGGHR 623
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 666 bits (1719), Expect = 0.0
Identities = 362/644 (56%), Positives = 441/644 (68%), Gaps = 33/644 (5%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
MNRYTT+RQLGDGTYGSVL+G+S ESGEL+AIK+MKRKFYSW+ECMNLREVKSLKKLNHA
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA 60
Query: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
NV+KLKEVIRENDHLYFIFEYMKENLYQL+K+RNKLFPES IRNIMYQILQGLAFIHKHG
Sbjct: 61 NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120
Query: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSP 180
FFHRD+KPENLLCMGPELVKIADFGLARE+RS+PPYTDYVSTRWYRAPEVLLRS+ YSSP
Sbjct: 121 FFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSP 180
Query: 181 IDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQ 240
IDVWAVG IMAE+Y LRPLFPG SE+D IFKICQVLGTPKK+DWPEGYQL+S+MNFR+PQ
Sbjct: 181 IDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQ 240
Query: 241 CVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESK 300
CVP NLKTLIPNAS+EA+QL+ +ML WDPKKRPTASQAL++PYFQVG LG ++ +L+
Sbjct: 241 CVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDS 300
Query: 301 QSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNL------- 353
+ K + P + KP+P Q +P + S + Q QPP +L
Sbjct: 301 EKPQKGILEKAGPPPYI----KPVPPA--QPPAKPHTRISSRQHQASQPPLHLTYPYKAE 354
Query: 354 -SVQQPPKQQSQEKPPQTLFPSIVKNMP-TKPNGTLSHKSG------RRRWG--QTIFKS 403
S P ++KP LFPS+ P +K L HK+G RRRWG K
Sbjct: 355 VSRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKD 414
Query: 404 GDSWEELEDYDFGASHSKKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTS 463
D W +L+D DF S S+ K+++ D+ R + + G S P TS
Sbjct: 415 SDDWADLDDLDFSPSLSRIDLKN--KKRQSDDTLCRFESVLDLKPSEPVGTGNSAPTQTS 472
Query: 464 LKSDSELSTAPTSKQYYLKQSRYLPGVNPKKVSLIASGKE-INPHTWSNQ-LFPKSLGPV 521
+ + +KQ+YLK SRYLPG++ + L GKE I P+ WS+ L KS G +
Sbjct: 473 YQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLSGKSSGTM 532
Query: 522 GAELAFKRSNAGNLGSYATYNQSGYIPSFLKKEVQSAGQRIHLAPLNATASEYTWNTKTG 581
+ K ++ G+ + ++ Y+PSFLKKE+ SA QR+HLAP+ + Y+ + K
Sbjct: 533 --SVISKVNSVGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHLAPIPDPSPGYS-SLKAM 589
Query: 582 RGQFSGRTYNPT--AKNLNIVNRAQPIPSVHGRTDWVAKYGGHR 623
R GR + T ++ R VHGRTDW +KY R
Sbjct: 590 R-PHPGRPFFHTQPRSTPGLIPRPPAAQPVHGRTDWASKYASRR 632
>gi|7662388 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 666 bits (1719), Expect = 0.0
Identities = 362/644 (56%), Positives = 441/644 (68%), Gaps = 33/644 (5%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
MNRYTT+RQLGDGTYGSVL+G+S ESGEL+AIK+MKRKFYSW+ECMNLREVKSLKKLNHA
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA 60
Query: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
NV+KLKEVIRENDHLYFIFEYMKENLYQL+K+RNKLFPES IRNIMYQILQGLAFIHKHG
Sbjct: 61 NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120
Query: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSP 180
FFHRD+KPENLLCMGPELVKIADFGLARE+RS+PPYTDYVSTRWYRAPEVLLRS+ YSSP
Sbjct: 121 FFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSP 180
Query: 181 IDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQ 240
IDVWAVG IMAE+Y LRPLFPG SE+D IFKICQVLGTPKK+DWPEGYQL+S+MNFR+PQ
Sbjct: 181 IDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQ 240
Query: 241 CVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESK 300
CVP NLKTLIPNAS+EA+QL+ +ML WDPKKRPTASQAL++PYFQVG LG ++ +L+
Sbjct: 241 CVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDS 300
Query: 301 QSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNL------- 353
+ K + P + KP+P Q +P + S + Q QPP +L
Sbjct: 301 EKPQKGILEKAGPPPYI----KPVPPA--QPPAKPHTRISSRQHQASQPPLHLTYPYKAE 354
Query: 354 -SVQQPPKQQSQEKPPQTLFPSIVKNMP-TKPNGTLSHKSG------RRRWG--QTIFKS 403
S P ++KP LFPS+ P +K L HK+G RRRWG K
Sbjct: 355 VSRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKD 414
Query: 404 GDSWEELEDYDFGASHSKKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTS 463
D W +L+D DF S S+ K+++ D+ R + + G S P TS
Sbjct: 415 SDDWADLDDLDFSPSLSRIDLKN--KKRQSDDTLCRFESVLDLKPSEPVGTGNSAPTQTS 472
Query: 464 LKSDSELSTAPTSKQYYLKQSRYLPGVNPKKVSLIASGKE-INPHTWSNQ-LFPKSLGPV 521
+ + +KQ+YLK SRYLPG++ + L GKE I P+ WS+ L KS G +
Sbjct: 473 YQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLSGKSSGTM 532
Query: 522 GAELAFKRSNAGNLGSYATYNQSGYIPSFLKKEVQSAGQRIHLAPLNATASEYTWNTKTG 581
+ K ++ G+ + ++ Y+PSFLKKE+ SA QR+HLAP+ + Y+ + K
Sbjct: 533 --SVISKVNSVGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHLAPIPDPSPGYS-SLKAM 589
Query: 582 RGQFSGRTYNPT--AKNLNIVNRAQPIPSVHGRTDWVAKYGGHR 623
R GR + T ++ R VHGRTDW +KY R
Sbjct: 590 R-PHPGRPFFHTQPRSTPGLIPRPPAAQPVHGRTDWASKYASRR 632
>gi|7657498 MAPK/MAK/MRK overlapping kinase [Homo sapiens]
Length = 419
Score = 226 bits (576), Expect = 5e-59
Identities = 116/288 (40%), Positives = 183/288 (63%), Gaps = 5/288 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-H 59
M Y + ++G+GT+ V+ +S G A K+MK++F S ++ NLRE+++L++LN H
Sbjct: 1 MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPH 60
Query: 60 ANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
N++ L EV+ R++ L I E M N+Y+L++ R E I + MYQ+ + L IH
Sbjct: 61 PNILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIH 120
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVY 177
++G FHRD+KPEN+L + +++K+ DFG R + S+ PYT+Y+STRWYRAPE LL Y
Sbjct: 121 RNGIFHRDVKPENIL-IKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFY 179
Query: 178 SSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFR 237
+ +D+W+ G + E+ L+PLFPG +E+D+I KI V+GTP + + ++ + +MNF
Sbjct: 180 TYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTK-FKQSRAMNFD 238
Query: 238 FPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
FP + L N S + + L+ M+ +DP +R A QAL+HPYFQ
Sbjct: 239 FPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQ 286
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 222 bits (565), Expect = 9e-58
Identities = 115/290 (39%), Positives = 180/290 (62%), Gaps = 9/290 (3%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMN---LREVKSLKKL 57
M YT + ++G+GTYG V G+ +G++VA+K+++ + S +E + +RE+ LK+L
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAIREISLLKEL 58
Query: 58 NHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKD--RNKLFPESVIRNIMYQILQGLAF 115
H N++ L++V+ ++ LY IFE++ +L + + + S++++ +YQILQG+ F
Sbjct: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118
Query: 116 IHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRS 174
H HRD+KP+NLL +K+ADFGLAR YT V T WYR+PEVLL S
Sbjct: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178
Query: 175 SVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSM 234
+ YS+P+D+W++G+I AEL +PLF G SE+D++F+I + LGTP WPE L
Sbjct: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238
Query: 235 NFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF 284
N FP+ P +L + + N + L+++ML +DP KR + AL HPYF
Sbjct: 239 N-TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 220 bits (561), Expect = 3e-57
Identities = 114/290 (39%), Positives = 179/290 (61%), Gaps = 9/290 (3%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMN---LREVKSLKKL 57
M YT + ++G+GTYG V G+ +G++VA+K+++ + S +E + +RE+ LK+L
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAIREISLLKEL 58
Query: 58 NHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKD--RNKLFPESVIRNIMYQILQGLAF 115
H N++ L++V+ ++ LY IFE++ +L + + + S++++ +YQILQG+ F
Sbjct: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118
Query: 116 IHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRS 174
H HRD+KP+NLL +K+ADFGLAR YT T WYR+PEVLL S
Sbjct: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGS 178
Query: 175 SVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSM 234
+ YS+P+D+W++G+I AEL +PLF G SE+D++F+I + LGTP WPE L
Sbjct: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238
Query: 235 NFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF 284
N FP+ P +L + + N + L+++ML +DP KR + AL HPYF
Sbjct: 239 N-TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 220 bits (561), Expect = 3e-57
Identities = 120/305 (39%), Positives = 179/305 (58%), Gaps = 6/305 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
M Y + +LG+GTY +V G+S + LVA+K ++ + C +REV LK L HA
Sbjct: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 248
Query: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
N++ L +++ + L +FEY+ ++L Q M D + ++ +YQIL+GLA+ H+
Sbjct: 249 NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRK 308
Query: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQP--PYTDYVSTRWYRAPEVLLRSSVYS 178
HRD+KP+NLL +K+ADFGLAR +S P Y++ V T WYR P+VLL SS YS
Sbjct: 309 VLHRDLKPQNLLINEKGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
Query: 179 SPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRF 238
+ ID+W VG I E+ RPLFPG++ DE+ I ++LGTP + WP N+ F
Sbjct: 368 TQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNF 427
Query: 239 PQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLE 298
P+ P L P +E I+L+T+ L ++ KKR +A +A+KH YF + LGP + L
Sbjct: 428 PKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF---RSLGPRIHALP 484
Query: 299 SKQSL 303
S+
Sbjct: 485 ESVSI 489
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 219 bits (559), Expect = 5e-57
Identities = 112/290 (38%), Positives = 177/290 (61%), Gaps = 10/290 (3%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKF-YSWDECMNLREVKSLKKLNH 59
M+ + + ++G+GTYG V K+ E+G+LVA+K+++ +RE+ LK+L H
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 60 ANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDR-NKLFPESVIRNIMYQILQGLAFIHK 118
N+++L +V+ LY +FE++ ++L + M P +I++ ++Q+LQG++F H
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120
Query: 119 HGFFHRDMKPENLLCMGPELVKIADFGLARE----LRSQPPYTDYVSTRWYRAPEVLLRS 174
H HRD+KP+NLL +K+ADFGLAR LR+ YT V T WYRAPE+LL S
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRT---YTHEVVTLWYRAPEILLGS 177
Query: 175 SVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSM 234
Y++ +D+W++G I AE+ + LFPG SE+D++F+I ++LGTP + WP QL
Sbjct: 178 KFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYK 237
Query: 235 NFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF 284
FP+ L+ ++PN E L+ ++L +DP +R TA AL HPYF
Sbjct: 238 G-SFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 216 bits (550), Expect = 5e-56
Identities = 113/289 (39%), Positives = 176/289 (60%), Gaps = 6/289 (2%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWD-ECMNLREVKSLKKLNH 59
M + + ++G+GTYG V ++ +GE+VA+K+++ + +RE+ LK+LNH
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 60 ANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKL--FPESVIRNIMYQILQGLAFIH 117
N++KL +VI + LY +FE++ ++L + M D + L P +I++ ++Q+LQGLAF H
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFM-DASALTGIPLPLIKSYLFQLLQGLAFCH 119
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQP-PYTDYVSTRWYRAPEVLLRSSV 176
H HRD+KP+NLL +K+ADFGLAR YT V T WYRAPE+LL
Sbjct: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
YS+ +D+W++G I AE+ R LFPG SE+D++F+I + LGTP + WP G
Sbjct: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP-GVTSMPDYKP 238
Query: 237 RFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
FP+ + ++P + L+++ML++DP KR +A AL HP+FQ
Sbjct: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 203 bits (516), Expect = 4e-52
Identities = 113/305 (37%), Positives = 172/305 (56%), Gaps = 6/305 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
+ Y + +LG+GTY +V G+S + LVA+K ++ + C +REV LK L HA
Sbjct: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHA 230
Query: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
N++ L ++I + L +FEY+ +L Q + L ++ M+Q+L+GLA+ H
Sbjct: 231 NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRK 290
Query: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQP--PYTDYVSTRWYRAPEVLLRSSVYS 178
HRD+KP+NLL +K+ADFGLAR +S P Y++ V T WYR P+VLL S+ YS
Sbjct: 291 ILHRDLKPQNLLINERGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 349
Query: 179 SPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRF 238
+PID+W VG I E+ RPLFPG++ +E+ I ++LGTP + WP + + F
Sbjct: 350 TPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSF 409
Query: 239 PQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLE 298
P +P L P + I L++ +L ++ K R +A AL H YF + LG + LE
Sbjct: 410 PCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF---RSLGERVHQLE 466
Query: 299 SKQSL 303
S+
Sbjct: 467 DTASI 471
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 203 bits (516), Expect = 4e-52
Identities = 113/305 (37%), Positives = 172/305 (56%), Gaps = 6/305 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
+ Y + +LG+GTY +V G+S + LVA+K ++ + C +REV LK L HA
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHA 200
Query: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
N++ L ++I + L +FEY+ +L Q + L ++ M+Q+L+GLA+ H
Sbjct: 201 NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRK 260
Query: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQP--PYTDYVSTRWYRAPEVLLRSSVYS 178
HRD+KP+NLL +K+ADFGLAR +S P Y++ V T WYR P+VLL S+ YS
Sbjct: 261 ILHRDLKPQNLLINERGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 319
Query: 179 SPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRF 238
+PID+W VG I E+ RPLFPG++ +E+ I ++LGTP + WP + + F
Sbjct: 320 TPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSF 379
Query: 239 PQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLE 298
P +P L P + I L++ +L ++ K R +A AL H YF + LG + LE
Sbjct: 380 PCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF---RSLGERVHQLE 436
Query: 299 SKQSL 303
S+
Sbjct: 437 DTASI 441
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 203 bits (516), Expect = 4e-52
Identities = 113/305 (37%), Positives = 172/305 (56%), Gaps = 6/305 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
+ Y + +LG+GTY +V G+S + LVA+K ++ + C +REV LK L HA
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHA 200
Query: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
N++ L ++I + L +FEY+ +L Q + L ++ M+Q+L+GLA+ H
Sbjct: 201 NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRK 260
Query: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQP--PYTDYVSTRWYRAPEVLLRSSVYS 178
HRD+KP+NLL +K+ADFGLAR +S P Y++ V T WYR P+VLL S+ YS
Sbjct: 261 ILHRDLKPQNLLINERGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 319
Query: 179 SPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRF 238
+PID+W VG I E+ RPLFPG++ +E+ I ++LGTP + WP + + F
Sbjct: 320 TPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSF 379
Query: 239 PQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLE 298
P +P L P + I L++ +L ++ K R +A AL H YF + LG + LE
Sbjct: 380 PCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF---RSLGERVHQLE 436
Query: 299 SKQSL 303
S+
Sbjct: 437 DTASI 441
>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
Length = 358
Score = 201 bits (511), Expect = 2e-51
Identities = 109/290 (37%), Positives = 172/290 (59%), Gaps = 7/290 (2%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKR-MKRKFYSWDECMNLREVKSLKKLNH 59
M +Y + ++G+G+YG V ++ ++G++VAIK+ ++ + + + LRE++ LK+L H
Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61
Query: 60 ANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKH 119
N++ L EV R L+ +FEY + + + PE ++++I +Q LQ + F HKH
Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKH 121
Query: 120 GFFHRDMKPENLLCMGPELVKIADFGLARELRSQPP-YTDYVSTRWYRAPEVLLRSSVYS 178
HRD+KPEN+L ++K+ DFG AR L YTDYV+TRWYR+PE+L+ + Y
Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYG 181
Query: 179 SPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLG--TPKKSDWPEGYQLASSMNF 236
P+DVWA+G + AEL PL+PG S+VD+++ I + LG P+ Q S +
Sbjct: 182 PPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKI 241
Query: 237 RFPQCV-PINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
P+ + P+ LK PN S A+ L+ L+ DP +R T Q L HPYF+
Sbjct: 242 PDPEDMEPLELK--FPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFE 289
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 197 bits (501), Expect = 2e-50
Identities = 102/286 (35%), Positives = 167/286 (58%), Gaps = 3/286 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
+ Y + +LG+GTY +V GKS + LVA+K ++ + C +REV LK L HA
Sbjct: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 227
Query: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
N++ L ++I L +FEY+ ++L Q + D + ++ ++Q+L+GLA+ H+
Sbjct: 228 NIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQK 287
Query: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQP--PYTDYVSTRWYRAPEVLLRSSVYS 178
HRD+KP+NLL +K+ADFGLAR +S P Y++ V T WYR P++LL S+ YS
Sbjct: 288 VLHRDLKPQNLLINERGELKLADFGLAR-AKSIPTKTYSNEVVTLWYRPPDILLGSTDYS 346
Query: 179 SPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRF 238
+ ID+W VG I E+ RPLFPG++ +++ I ++LGTP + WP + +
Sbjct: 347 TQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNY 406
Query: 239 PQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF 284
P+ L + P ++ L+T++L ++ + R +A A+KHP+F
Sbjct: 407 PKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 197 bits (501), Expect = 2e-50
Identities = 102/286 (35%), Positives = 167/286 (58%), Gaps = 3/286 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
+ Y + +LG+GTY +V GKS + LVA+K ++ + C +REV LK L HA
Sbjct: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 221
Query: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
N++ L ++I L +FEY+ ++L Q + D + ++ ++Q+L+GLA+ H+
Sbjct: 222 NIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQK 281
Query: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQP--PYTDYVSTRWYRAPEVLLRSSVYS 178
HRD+KP+NLL +K+ADFGLAR +S P Y++ V T WYR P++LL S+ YS
Sbjct: 282 VLHRDLKPQNLLINERGELKLADFGLAR-AKSIPTKTYSNEVVTLWYRPPDILLGSTDYS 340
Query: 179 SPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRF 238
+ ID+W VG I E+ RPLFPG++ +++ I ++LGTP + WP + +
Sbjct: 341 TQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNY 400
Query: 239 PQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF 284
P+ L + P ++ L+T++L ++ + R +A A+KHP+F
Sbjct: 401 PKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 446
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 196 bits (498), Expect = 5e-50
Identities = 110/318 (34%), Positives = 179/318 (56%), Gaps = 6/318 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWD-ECMNLREVKSLKKLNH 59
MN++ + +G+G YG VL + E+ E+VAIK+ K + + + LRE+K L+ L
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
Query: 60 ANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKH 119
N+++LKE R LY +FEY+++N+ +L+++ P +++ +YQ+++ + + HK+
Sbjct: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
Query: 120 GFFHRDMKPENLLCMGPELVKIADFGLARELR--SQPPYTDYVSTRWYRAPEVLLRSSVY 177
HRD+KPENLL +++K+ DFG AR L + YT+YV+TRWYR+PE+LL + Y
Sbjct: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
Query: 178 SSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFR 237
+D+W+VG I+ EL +PLFPG SE+D++F I +VLG Y R
Sbjct: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
Query: 238 FPQC-VPINLKTLIPNASNEA-IQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSN 295
FP P +L+ N + LM +L DP R Q L HP FQ ++L S +
Sbjct: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
Query: 296 HLESKQSLNKQLQPLESK 313
++ + + L ++
Sbjct: 309 RSAKRKPYHVESSTLSNR 326
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 196 bits (498), Expect = 5e-50
Identities = 110/318 (34%), Positives = 179/318 (56%), Gaps = 6/318 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWD-ECMNLREVKSLKKLNH 59
MN++ + +G+G YG VL + E+ E+VAIK+ K + + + LRE+K L+ L
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
Query: 60 ANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKH 119
N+++LKE R LY +FEY+++N+ +L+++ P +++ +YQ+++ + + HK+
Sbjct: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
Query: 120 GFFHRDMKPENLLCMGPELVKIADFGLARELR--SQPPYTDYVSTRWYRAPEVLLRSSVY 177
HRD+KPENLL +++K+ DFG AR L + YT+YV+TRWYR+PE+LL + Y
Sbjct: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
Query: 178 SSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFR 237
+D+W+VG I+ EL +PLFPG SE+D++F I +VLG Y R
Sbjct: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
Query: 238 FPQC-VPINLKTLIPNASNEA-IQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSN 295
FP P +L+ N + LM +L DP R Q L HP FQ ++L S +
Sbjct: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
Query: 296 HLESKQSLNKQLQPLESK 313
++ + + L ++
Sbjct: 309 RSAKRKPYHVESSTLSNR 326
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 193 bits (490), Expect = 5e-49
Identities = 101/288 (35%), Positives = 171/288 (59%), Gaps = 4/288 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMK-RKFYSWDECMNLREVKSLKKL-N 58
M++Y + ++G+G +G V K E+GE+VA+K++ R+ LRE+K+L+++ +
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 59 HANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHK 118
+ V++LK V FE+M +L ++++ + ++ +++ + +L+G+AF H
Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120
Query: 119 HGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPP--YTDYVSTRWYRAPEVLLRSSV 176
+ HRD+KP NLL +KIADFGLAR YT V+TRWYRAPE+L +
Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ 180
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
Y +D+W+VG IM EL PLFPG ++++++ + ++LGTP WPE +L
Sbjct: 181 YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 240
Query: 237 RFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF 284
F + VP+ L+ ++P+ S +A+ L+ + L + P +R AS+AL H YF
Sbjct: 241 SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 288
>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
Length = 493
Score = 191 bits (486), Expect = 1e-48
Identities = 117/343 (34%), Positives = 185/343 (53%), Gaps = 36/343 (10%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDEC-----MNLREVKSLK 55
M +Y + +G+G+YG V+ ++ ++G +VAIK KF D+ + +RE+K LK
Sbjct: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIK----KFLESDDDKMVKKIAMREIKLLK 56
Query: 56 KLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPES----VIRNIMYQILQ 111
+L H N++ L EV ++ Y +FE++ + D +LFP V++ ++QI+
Sbjct: 57 QLRHENLVNLLEVCKKKKRWYLVFEFVDHTIL----DDLELFPNGLDYQVVQKYLFQIIN 112
Query: 112 GLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPP-YTDYVSTRWYRAPEV 170
G+ F H H HRD+KPEN+L +VK+ DFG AR L + YTDYV+TRWYRAPE+
Sbjct: 113 GIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPEL 172
Query: 171 LLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGT--PKKSDWPEGY 228
L+ Y +DVWA+G ++ E++M PLFPG S++D+++ I LG P+ +
Sbjct: 173 LVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKN 232
Query: 229 QLASSMNFRFPQCVPIN-LKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVG 287
+ + + R P+ L+ P S I L + L+ DP KRP ++ L H +FQ+
Sbjct: 233 PVFAGV--RLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMD 290
Query: 288 QVLGPSSNHLE------------SKQSLNKQLQPLESKPSLVE 318
S L+ SK+S N++ + E SLVE
Sbjct: 291 GFAERFSQELQLKVQKDARNVSLSKKSQNRKKEK-EKDDSLVE 332
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 191 bits (484), Expect = 2e-48
Identities = 106/289 (36%), Positives = 170/289 (58%), Gaps = 4/289 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKR-KFYSWDECMNLREVKSLKKLNH 59
+ + + ++G+GTYG V + ++ E+VA+K+++ K +LRE+ L +L H
Sbjct: 36 VKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRH 95
Query: 60 ANVIKLKEVIREN--DHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
N+++LKEV+ N + ++ + Y +++L L+++ F E+ ++ I+ Q+L+GL ++H
Sbjct: 96 PNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLH 155
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSV 176
++ HRD+K NLL VK ADFGLAR P T V T WYRAPE+LL ++
Sbjct: 156 RNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTT 215
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
++ ID+WAVG I+AEL RPL PGTSE+ +I I Q+LGTP ++ WP +L +
Sbjct: 216 QTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQY 275
Query: 237 RFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
+ NLK P S ++L+ + +DPKKR TA L+ YF+
Sbjct: 276 SLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFK 324
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 189 bits (481), Expect = 5e-48
Identities = 102/290 (35%), Positives = 164/290 (56%), Gaps = 5/290 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMK-RKFYSWDECMNLREVKSLKKLNH 59
+ + + ++ +GTYG V K ++ E+VA+KR+K K +LRE+ ++ K H
Sbjct: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
Query: 60 ANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
N++ ++E++ D +Y + Y++ +L LM+ + F ++ +M Q+L+G+ +H
Sbjct: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 529
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSV 176
+ HRD+K NLL ++K+ DFGLARE S YT V T+WYRAPE+LL +
Sbjct: 530 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKE 589
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
YS+ +D+W+VG I EL +PLFPG SE+D+I K+ + LGTP + WP +L
Sbjct: 590 YSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKM 649
Query: 237 RFPQCVPINL-KTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
F + NL K S++ LM + L + P +R +A LKH YF+
Sbjct: 650 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 699
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 189 bits (481), Expect = 5e-48
Identities = 102/290 (35%), Positives = 164/290 (56%), Gaps = 5/290 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMK-RKFYSWDECMNLREVKSLKKLNH 59
+ + + ++ +GTYG V K ++ E+VA+KR+K K +LRE+ ++ K H
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479
Query: 60 ANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
N++ ++E++ D +Y + Y++ +L LM+ + F ++ +M Q+L+G+ +H
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSV 176
+ HRD+K NLL ++K+ DFGLARE S YT V T+WYRAPE+LL +
Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKE 599
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
YS+ +D+W+VG I EL +PLFPG SE+D+I K+ + LGTP + WP +L
Sbjct: 600 YSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKM 659
Query: 237 RFPQCVPINL-KTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
F + NL K S++ LM + L + P +R +A LKH YF+
Sbjct: 660 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 189 bits (479), Expect = 9e-48
Identities = 102/290 (35%), Positives = 164/290 (56%), Gaps = 5/290 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMK-RKFYSWDECMNLREVKSLKKLNH 59
+ + + ++ +GTYG V K ++ E+VA+KR+K K +LRE+ ++ K H
Sbjct: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
Query: 60 ANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
N++ ++E++ D +Y + Y++ +L LM+ + F ++ +M Q+L+G+ +H
Sbjct: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 530
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSV 176
+ HRD+K NLL ++K+ DFGLARE S YT V T WYRAPE+LL +
Sbjct: 531 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 590
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
YS+ +D+W+VG I EL +PLFPG SE+D+I K+ + LGTP + WP +L +
Sbjct: 591 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 650
Query: 237 RFPQCVPINL-KTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
F + NL K S++ LM + L + P +R +A LKH YF+
Sbjct: 651 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 700
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 189 bits (479), Expect = 9e-48
Identities = 102/290 (35%), Positives = 164/290 (56%), Gaps = 5/290 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMK-RKFYSWDECMNLREVKSLKKLNH 59
+ + + ++ +GTYG V K ++ E+VA+KR+K K +LRE+ ++ K H
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479
Query: 60 ANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
N++ ++E++ D +Y + Y++ +L LM+ + F ++ +M Q+L+G+ +H
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSV 176
+ HRD+K NLL ++K+ DFGLARE S YT V T WYRAPE+LL +
Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 599
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
YS+ +D+W+VG I EL +PLFPG SE+D+I K+ + LGTP + WP +L +
Sbjct: 600 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 659
Query: 237 RFPQCVPINL-KTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
F + NL K S++ LM + L + P +R +A LKH YF+
Sbjct: 660 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 189 bits (479), Expect = 9e-48
Identities = 102/290 (35%), Positives = 164/290 (56%), Gaps = 5/290 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMK-RKFYSWDECMNLREVKSLKKLNH 59
+ + + ++ +GTYG V K ++ E+VA+KR+K K +LRE+ ++ K H
Sbjct: 388 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 447
Query: 60 ANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
N++ ++E++ D +Y + Y++ +L LM+ + F ++ +M Q+L+G+ +H
Sbjct: 448 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 507
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSV 176
+ HRD+K NLL ++K+ DFGLARE S YT V T WYRAPE+LL +
Sbjct: 508 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 567
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
YS+ +D+W+VG I EL +PLFPG SE+D+I K+ + LGTP + WP +L +
Sbjct: 568 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 627
Query: 237 RFPQCVPINL-KTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
F + NL K S++ LM + L + P +R +A LKH YF+
Sbjct: 628 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 677
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 189 bits (479), Expect = 9e-48
Identities = 102/290 (35%), Positives = 164/290 (56%), Gaps = 5/290 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMK-RKFYSWDECMNLREVKSLKKLNH 59
+ + + ++ +GTYG V K ++ E+VA+KR+K K +LRE+ ++ K H
Sbjct: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
Query: 60 ANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
N++ ++E++ D +Y + Y++ +L LM+ + F ++ +M Q+L+G+ +H
Sbjct: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 496
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSV 176
+ HRD+K NLL ++K+ DFGLARE S YT V T WYRAPE+LL +
Sbjct: 497 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 556
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
YS+ +D+W+VG I EL +PLFPG SE+D+I K+ + LGTP + WP +L +
Sbjct: 557 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 616
Query: 237 RFPQCVPINL-KTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
F + NL K S++ LM + L + P +R +A LKH YF+
Sbjct: 617 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 666
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 189 bits (479), Expect = 9e-48
Identities = 102/290 (35%), Positives = 164/290 (56%), Gaps = 5/290 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMK-RKFYSWDECMNLREVKSLKKLNH 59
+ + + ++ +GTYG V K ++ E+VA+KR+K K +LRE+ ++ K H
Sbjct: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225
Query: 60 ANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
N++ ++E++ D +Y + Y++ +L LM+ + F ++ +M Q+L+G+ +H
Sbjct: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 285
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSV 176
+ HRD+K NLL ++K+ DFGLARE S YT V T WYRAPE+LL +
Sbjct: 286 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 345
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
YS+ +D+W+VG I EL +PLFPG SE+D+I K+ + LGTP + WP +L +
Sbjct: 346 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 405
Query: 237 RFPQCVPINL-KTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
F + NL K S++ LM + L + P +R +A LKH YF+
Sbjct: 406 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 455
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 189 bits (479), Expect = 9e-48
Identities = 102/290 (35%), Positives = 164/290 (56%), Gaps = 5/290 (1%)
Query: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMK-RKFYSWDECMNLREVKSLKKLNH 59
+ + + ++ +GTYG V K ++ E+VA+KR+K K +LRE+ ++ K H
Sbjct: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481
Query: 60 ANVIKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIH 117
N++ ++E++ D +Y + Y++ +L LM+ + F ++ +M Q+L+G+ +H
Sbjct: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 541
Query: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSV 176
+ HRD+K NLL ++K+ DFGLARE S YT V T WYRAPE+LL +
Sbjct: 542 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 601
Query: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
YS+ +D+W+VG I EL +PLFPG SE+D+I K+ + LGTP + WP +L +
Sbjct: 602 YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM 661
Query: 237 RFPQCVPINL-KTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
F + NL K S++ LM + L + P +R +A LKH YF+
Sbjct: 662 TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 711
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 187 bits (474), Expect = 3e-47
Identities = 105/288 (36%), Positives = 169/288 (58%), Gaps = 9/288 (3%)
Query: 3 RYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSW-DECMN---LREVKSLKKLN 58
RY + LG+G + +V + + ++VAIK++K S + +N LRE+K L++L+
Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70
Query: 59 HANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHK 118
H N+I L + ++ +F++M+ +L ++KD + + S I+ M LQGL ++H+
Sbjct: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130
Query: 119 HGFFHRDMKPENLLCMGPELVKIADFGLARELRS-QPPYTDYVSTRWYRAPEVLLRSSVY 177
H HRD+KP NLL ++K+ADFGLA+ S YT V TRWYRAPE+L + +Y
Sbjct: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190
Query: 178 SSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFR 237
+D+WAVG I+AEL + P PG S++D++ +I + LGTP + WP+ L + F+
Sbjct: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250
Query: 238 -FPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF 284
FP I L + A ++ + L+ + ++P R TA+QALK YF
Sbjct: 251 SFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 185 bits (470), Expect = 9e-47
Identities = 117/334 (35%), Positives = 175/334 (52%), Gaps = 29/334 (8%)
Query: 3 RYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMN-LREVKSLKKLNHAN 61
RYT + +G+G YG V N + VAIK++ F C LRE+K L + H N
Sbjct: 24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHEN 82
Query: 62 VIKLKEVIR-----ENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFI 116
+I + ++IR + +Y + + M+ +LY+L+K ++ I +YQIL+GL +I
Sbjct: 83 IIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYI 140
Query: 117 HKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYT----DYVSTRWYRAPEVLL 172
H HRD+KP NLL +KI DFGLAR +T +YV+TRWYRAPE++L
Sbjct: 141 HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML 200
Query: 173 RSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQL-A 231
S Y+ ID+W+VG I+AE+ RP+FPG +D++ I +LG+P + D L A
Sbjct: 201 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKA 260
Query: 232 SSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLG 291
+ P + L PNA ++A+ L+ +ML ++P KR QAL HPY + Q
Sbjct: 261 RNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLE--QYYD 318
Query: 292 PSSNHLESKQSLNKQLQPLESKPSLVEVEPKPLP 325
PS +P+ P ++E LP
Sbjct: 319 PSD-------------EPIAEAPFKFDMELDDLP 339
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,397,653
Number of Sequences: 37866
Number of extensions: 1344635
Number of successful extensions: 8136
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 743
Number of HSP's successfully gapped in prelim test: 256
Number of HSP's that attempted gapping in prelim test: 4707
Number of HSP's gapped (non-prelim): 1936
length of query: 623
length of database: 18,247,518
effective HSP length: 108
effective length of query: 515
effective length of database: 14,157,990
effective search space: 7291364850
effective search space used: 7291364850
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.