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Search of human proteins with 21956645
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21956645 myotrophin [Homo sapiens]
(118 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21956645 myotrophin [Homo sapiens] 243 3e-65
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 73 5e-14
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 73 5e-14
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 73 5e-14
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 70 5e-13
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 67 2e-12
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 67 3e-12
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 67 4e-12
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 66 5e-12
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 66 7e-12
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 65 1e-11
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 65 1e-11
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 65 1e-11
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 65 1e-11
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 65 1e-11
gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapi... 65 1e-11
gi|10863929 ribonuclease L [Homo sapiens] 63 4e-11
gi|156142184 ankyrin repeat domain 39 [Homo sapiens] 63 4e-11
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 63 6e-11
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 63 6e-11
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 63 6e-11
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 63 6e-11
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 62 1e-10
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 62 1e-10
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 62 1e-10
gi|34304383 Usher syndrome 1G protein [Homo sapiens] 61 2e-10
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 60 3e-10
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 60 5e-10
gi|4506499 regulatory factor X-associated ankyrin-containing pro... 59 6e-10
gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo sa... 59 8e-10
>gi|21956645 myotrophin [Homo sapiens]
Length = 118
Score = 243 bits (619), Expect = 3e-65
Identities = 118/118 (100%), Positives = 118/118 (100%)
Query: 1 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGAD 60
MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGAD
Sbjct: 1 MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGAD 60
Query: 61 INAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
INAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ
Sbjct: 61 INAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 72.8 bits (177), Expect = 5e-14
Identities = 40/114 (35%), Positives = 63/114 (55%), Gaps = 4/114 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G + V++ + +G V+ + G LH A+ GQ E+++ L+ +GA+INA ++
Sbjct: 50 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
TPL A E H+ VK LL GA+++ DG T A + NQA+ LL+
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 163
Score = 60.5 bits (145), Expect = 3e-10
Identities = 37/95 (38%), Positives = 52/95 (54%), Gaps = 4/95 (4%)
Query: 28 VNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLL 87
VNRT E G PLH AA G + + LL +GA ++ ++ ITPL A G+ + VKLL
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Query: 88 LSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
L +G K DGLT A + +Q ++ LL+
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 299
Score = 58.5 bits (140), Expect = 1e-09
Identities = 34/81 (41%), Positives = 43/81 (53%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
KG + T + G PLH AA Q++I LL GA+ N K +TPL A EGH
Sbjct: 597 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 656
Query: 84 VKLLLSKGADKTVKGPDGLTA 104
V LLL KGA+ + GLT+
Sbjct: 657 VTLLLDKGANIHMSTKSGLTS 677
Score = 53.5 bits (127), Expect = 3e-08
Identities = 35/96 (36%), Positives = 49/96 (51%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G+ + VK + +G ++ G PLH AA G +++E LL +GA + A K+
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
++PL A HV CVK LL A D LTA
Sbjct: 312 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
Score = 53.1 bits (126), Expect = 4e-08
Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 4/114 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + G D V + KG +++ + + G LH AA ++ + + L GAD +A K
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQA----IKALLQ 118
TPL+ A + G+V V LL +GA+ K +G T Q I LLQ
Sbjct: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 761
Score = 52.8 bits (125), Expect = 6e-08
Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 4/99 (4%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
+G V+ T G PLH A+ G +++ LL +G I+A + +TPL A GH
Sbjct: 234 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 293
Query: 84 VKLLLSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
V+LLL +GA + +GL+ A + + +K LLQ
Sbjct: 294 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 332
Score = 52.0 bits (123), Expect = 1e-07
Identities = 32/92 (34%), Positives = 47/92 (51%), Gaps = 1/92 (1%)
Query: 14 DLDEVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
D V D + K G D + + G PL A G ++++ FLL +GA++NA K+ TPL
Sbjct: 685 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 744
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
A +GH + +LL GA +G TA
Sbjct: 745 HQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776
Score = 51.6 bits (122), Expect = 1e-07
Identities = 31/106 (29%), Positives = 52/106 (49%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G + VK V +G ++N + G PL+ AA ++++++LL GA+ + + TPL
Sbjct: 87 GQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPL 146
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
A+ +GH V +LL V+ P A D ++ LLQ
Sbjct: 147 AVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Score = 47.4 bits (111), Expect = 2e-06
Identities = 28/81 (34%), Positives = 41/81 (50%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
K + N G PLH A +++++E L+ GA I A + +TP+ A + GH++
Sbjct: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
Query: 84 VKLLLSKGADKTVKGPDGLTA 104
V LLL GA V G TA
Sbjct: 426 VLLLLQNGASPDVTNIRGETA 446
Score = 45.1 bits (105), Expect = 1e-05
Identities = 31/86 (36%), Positives = 40/86 (46%), Gaps = 3/86 (3%)
Query: 35 GRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
G PLH +A GQ+++ LL GA + K TPL A G + KLLL + A
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
Query: 95 TVKGPDGLTAFEAT---DNQAIKALL 117
G +GLT DNQ + LL
Sbjct: 569 DSAGKNGLTPLHVAAHYDNQKVALLL 594
Score = 43.5 bits (101), Expect = 4e-05
Identities = 27/93 (29%), Positives = 43/93 (46%)
Query: 11 KNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHIT 70
+ G +D + G + + G PLH AA G L++ + LL + A ++ K+ +T
Sbjct: 518 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLT 577
Query: 71 PLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
PL A + + LLL KGA +G T
Sbjct: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYT 610
Score = 43.1 bits (100), Expect = 5e-05
Identities = 29/95 (30%), Positives = 43/95 (45%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G LD K + + + + G PLH AA ++ LL KGA +A K+
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
TPL A + + LL+ GA+ + G+T
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 643
Score = 42.7 bits (99), Expect = 6e-05
Identities = 28/95 (29%), Positives = 42/95 (44%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K + + G + N + G PLH A+ G +++ LL KGA+I+ K
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+T L A E V+ +L GAD+ G T
Sbjct: 675 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 709
Score = 42.4 bits (98), Expect = 8e-05
Identities = 28/95 (29%), Positives = 45/95 (47%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + G ++ V+ + G V+ + PLH A+ G+ EI++ LL A +A +
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 509
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
TPL + EG V +LL GA ++ G T
Sbjct: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFT 544
Score = 41.6 bits (96), Expect = 1e-04
Identities = 27/95 (28%), Positives = 45/95 (47%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A ++G V+ + +G + + G PLH AA +E ++ LL A ++ +
Sbjct: 285 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 344
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+T L A + GH KLLL K A+ + +G T
Sbjct: 345 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT 379
Score = 40.0 bits (92), Expect = 4e-04
Identities = 26/75 (34%), Positives = 36/75 (48%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G++ V + +G +VN + G PLH AA G I+ LL GA NA + T L
Sbjct: 718 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 777
Query: 73 LSAVYEGHVSCVKLL 87
A G++S V L
Sbjct: 778 AIAKRLGYISVVDTL 792
Score = 39.3 bits (90), Expect = 7e-04
Identities = 27/84 (32%), Positives = 36/84 (42%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K + ++ V G + E G P+H AA G L I+ LL GA + +
Sbjct: 384 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 443
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGA 92
T L A G V V+ LL GA
Sbjct: 444 ETALHMAARAGQVEVVRCLLRNGA 467
Score = 39.3 bits (90), Expect = 7e-04
Identities = 30/91 (32%), Positives = 41/91 (45%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G L+ V + G + T G LH AA GQ+E++ LL GA ++A + TPL
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 480
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
A G V+LLL A +G T
Sbjct: 481 HIASRLGKTEIVQLLLQHMAHPDAATTNGYT 511
Score = 37.7 bits (86), Expect = 0.002
Identities = 23/65 (35%), Positives = 32/65 (49%)
Query: 39 LHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKG 98
LH AA CG + + LL K A+ NA + TPL A + + ++LL+ GA
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
Query: 99 PDGLT 103
GLT
Sbjct: 408 ESGLT 412
Score = 33.5 bits (75), Expect = 0.037
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 42 AADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDG 101
AA G L+ + L G DIN +++ + L A EGHV V+ LL +G+ G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 102 LTAFE----ATDNQAIKALLQ 118
TA A + +K L++
Sbjct: 77 NTALHIASLAGQAEVVKVLVK 97
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 72.8 bits (177), Expect = 5e-14
Identities = 40/114 (35%), Positives = 63/114 (55%), Gaps = 4/114 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G + V++ + +G V+ + G LH A+ GQ E+++ L+ +GA+INA ++
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
TPL A E H+ VK LL GA+++ DG T A + NQA+ LL+
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 184
Score = 60.5 bits (145), Expect = 3e-10
Identities = 37/95 (38%), Positives = 52/95 (54%), Gaps = 4/95 (4%)
Query: 28 VNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLL 87
VNRT E G PLH AA G + + LL +GA ++ ++ ITPL A G+ + VKLL
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 88 LSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
L +G K DGLT A + +Q ++ LL+
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Score = 58.5 bits (140), Expect = 1e-09
Identities = 34/81 (41%), Positives = 43/81 (53%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
KG + T + G PLH AA Q++I LL GA+ N K +TPL A EGH
Sbjct: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
Query: 84 VKLLLSKGADKTVKGPDGLTA 104
V LLL KGA+ + GLT+
Sbjct: 678 VTLLLDKGANIHMSTKSGLTS 698
Score = 53.5 bits (127), Expect = 3e-08
Identities = 35/96 (36%), Positives = 49/96 (51%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G+ + VK + +G ++ G PLH AA G +++E LL +GA + A K+
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
++PL A HV CVK LL A D LTA
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 368
Score = 53.1 bits (126), Expect = 4e-08
Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 4/114 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + G D V + KG +++ + + G LH AA ++ + + L GAD +A K
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQA----IKALLQ 118
TPL+ A + G+V V LL +GA+ K +G T Q I LLQ
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
Score = 52.8 bits (125), Expect = 6e-08
Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 4/99 (4%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
+G V+ T G PLH A+ G +++ LL +G I+A + +TPL A GH
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 314
Query: 84 VKLLLSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
V+LLL +GA + +GL+ A + + +K LLQ
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353
Score = 52.0 bits (123), Expect = 1e-07
Identities = 32/92 (34%), Positives = 47/92 (51%), Gaps = 1/92 (1%)
Query: 14 DLDEVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
D V D + K G D + + G PL A G ++++ FLL +GA++NA K+ TPL
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
A +GH + +LL GA +G TA
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Score = 51.6 bits (122), Expect = 1e-07
Identities = 31/106 (29%), Positives = 52/106 (49%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G + VK V +G ++N + G PL+ AA ++++++LL GA+ + + TPL
Sbjct: 108 GQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPL 167
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
A+ +GH V +LL V+ P A D ++ LLQ
Sbjct: 168 AVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Score = 47.4 bits (111), Expect = 2e-06
Identities = 28/81 (34%), Positives = 41/81 (50%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
K + N G PLH A +++++E L+ GA I A + +TP+ A + GH++
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
Query: 84 VKLLLSKGADKTVKGPDGLTA 104
V LLL GA V G TA
Sbjct: 447 VLLLLQNGASPDVTNIRGETA 467
Score = 45.1 bits (105), Expect = 1e-05
Identities = 31/86 (36%), Positives = 40/86 (46%), Gaps = 3/86 (3%)
Query: 35 GRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
G PLH +A GQ+++ LL GA + K TPL A G + KLLL + A
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 95 TVKGPDGLTAFEAT---DNQAIKALL 117
G +GLT DNQ + LL
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLL 615
Score = 43.5 bits (101), Expect = 4e-05
Identities = 27/93 (29%), Positives = 43/93 (46%)
Query: 11 KNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHIT 70
+ G +D + G + + G PLH AA G L++ + LL + A ++ K+ +T
Sbjct: 539 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLT 598
Query: 71 PLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
PL A + + LLL KGA +G T
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYT 631
Score = 43.1 bits (100), Expect = 5e-05
Identities = 29/95 (30%), Positives = 43/95 (45%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G LD K + + + + G PLH AA ++ LL KGA +A K+
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
TPL A + + LL+ GA+ + G+T
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
Score = 42.7 bits (99), Expect = 6e-05
Identities = 28/95 (29%), Positives = 42/95 (44%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K + + G + N + G PLH A+ G +++ LL KGA+I+ K
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+T L A E V+ +L GAD+ G T
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Score = 42.4 bits (98), Expect = 8e-05
Identities = 28/95 (29%), Positives = 45/95 (47%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + G ++ V+ + G V+ + PLH A+ G+ EI++ LL A +A +
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
TPL + EG V +LL GA ++ G T
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFT 565
Score = 41.6 bits (96), Expect = 1e-04
Identities = 27/95 (28%), Positives = 45/95 (47%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A ++G V+ + +G + + G PLH AA +E ++ LL A ++ +
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+T L A + GH KLLL K A+ + +G T
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT 400
Score = 40.0 bits (92), Expect = 4e-04
Identities = 26/75 (34%), Positives = 36/75 (48%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G++ V + +G +VN + G PLH AA G I+ LL GA NA + T L
Sbjct: 739 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Query: 73 LSAVYEGHVSCVKLL 87
A G++S V L
Sbjct: 799 AIAKRLGYISVVDTL 813
Score = 39.3 bits (90), Expect = 7e-04
Identities = 27/84 (32%), Positives = 36/84 (42%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K + ++ V G + E G P+H AA G L I+ LL GA + +
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGA 92
T L A G V V+ LL GA
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGA 488
Score = 39.3 bits (90), Expect = 7e-04
Identities = 30/91 (32%), Positives = 41/91 (45%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G L+ V + G + T G LH AA GQ+E++ LL GA ++A + TPL
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
A G V+LLL A +G T
Sbjct: 502 HIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532
Score = 37.7 bits (86), Expect = 0.002
Identities = 23/65 (35%), Positives = 32/65 (49%)
Query: 39 LHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKG 98
LH AA CG + + LL K A+ NA + TPL A + + ++LL+ GA
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
Query: 99 PDGLT 103
GLT
Sbjct: 429 ESGLT 433
Score = 33.5 bits (75), Expect = 0.037
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 42 AADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDG 101
AA G L+ + L G DIN +++ + L A EGHV V+ LL +G+ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 102 LTAFE----ATDNQAIKALLQ 118
TA A + +K L++
Sbjct: 98 NTALHIASLAGQAEVVKVLVK 118
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 72.8 bits (177), Expect = 5e-14
Identities = 40/114 (35%), Positives = 63/114 (55%), Gaps = 4/114 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G + V++ + +G V+ + G LH A+ GQ E+++ L+ +GA+INA ++
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
TPL A E H+ VK LL GA+++ DG T A + NQA+ LL+
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 184
Score = 60.5 bits (145), Expect = 3e-10
Identities = 37/95 (38%), Positives = 52/95 (54%), Gaps = 4/95 (4%)
Query: 28 VNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLL 87
VNRT E G PLH AA G + + LL +GA ++ ++ ITPL A G+ + VKLL
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 88 LSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
L +G K DGLT A + +Q ++ LL+
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Score = 58.5 bits (140), Expect = 1e-09
Identities = 34/81 (41%), Positives = 43/81 (53%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
KG + T + G PLH AA Q++I LL GA+ N K +TPL A EGH
Sbjct: 618 KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
Query: 84 VKLLLSKGADKTVKGPDGLTA 104
V LLL KGA+ + GLT+
Sbjct: 678 VTLLLDKGANIHMSTKSGLTS 698
Score = 53.5 bits (127), Expect = 3e-08
Identities = 35/96 (36%), Positives = 49/96 (51%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G+ + VK + +G ++ G PLH AA G +++E LL +GA + A K+
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
++PL A HV CVK LL A D LTA
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 368
Score = 53.1 bits (126), Expect = 4e-08
Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 4/114 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + G D V + KG +++ + + G LH AA ++ + + L GAD +A K
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQA----IKALLQ 118
TPL+ A + G+V V LL +GA+ K +G T Q I LLQ
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
Score = 52.8 bits (125), Expect = 6e-08
Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 4/99 (4%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
+G V+ T G PLH A+ G +++ LL +G I+A + +TPL A GH
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 314
Query: 84 VKLLLSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
V+LLL +GA + +GL+ A + + +K LLQ
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353
Score = 52.0 bits (123), Expect = 1e-07
Identities = 32/92 (34%), Positives = 47/92 (51%), Gaps = 1/92 (1%)
Query: 14 DLDEVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
D V D + K G D + + G PL A G ++++ FLL +GA++NA K+ TPL
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
A +GH + +LL GA +G TA
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Score = 51.6 bits (122), Expect = 1e-07
Identities = 31/106 (29%), Positives = 52/106 (49%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G + VK V +G ++N + G PL+ AA ++++++LL GA+ + + TPL
Sbjct: 108 GQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPL 167
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
A+ +GH V +LL V+ P A D ++ LLQ
Sbjct: 168 AVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Score = 47.4 bits (111), Expect = 2e-06
Identities = 28/81 (34%), Positives = 41/81 (50%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
K + N G PLH A +++++E L+ GA I A + +TP+ A + GH++
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
Query: 84 VKLLLSKGADKTVKGPDGLTA 104
V LLL GA V G TA
Sbjct: 447 VLLLLQNGASPDVTNIRGETA 467
Score = 45.1 bits (105), Expect = 1e-05
Identities = 31/86 (36%), Positives = 40/86 (46%), Gaps = 3/86 (3%)
Query: 35 GRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
G PLH +A GQ+++ LL GA + K TPL A G + KLLL + A
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 95 TVKGPDGLTAFEAT---DNQAIKALL 117
G +GLT DNQ + LL
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLL 615
Score = 43.5 bits (101), Expect = 4e-05
Identities = 27/93 (29%), Positives = 43/93 (46%)
Query: 11 KNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHIT 70
+ G +D + G + + G PLH AA G L++ + LL + A ++ K+ +T
Sbjct: 539 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLT 598
Query: 71 PLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
PL A + + LLL KGA +G T
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYT 631
Score = 43.1 bits (100), Expect = 5e-05
Identities = 29/95 (30%), Positives = 43/95 (45%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G LD K + + + + G PLH AA ++ LL KGA +A K+
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
TPL A + + LL+ GA+ + G+T
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
Score = 42.7 bits (99), Expect = 6e-05
Identities = 28/95 (29%), Positives = 42/95 (44%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K + + G + N + G PLH A+ G +++ LL KGA+I+ K
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+T L A E V+ +L GAD+ G T
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Score = 42.4 bits (98), Expect = 8e-05
Identities = 28/95 (29%), Positives = 45/95 (47%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + G ++ V+ + G V+ + PLH A+ G+ EI++ LL A +A +
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
TPL + EG V +LL GA ++ G T
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFT 565
Score = 41.6 bits (96), Expect = 1e-04
Identities = 27/95 (28%), Positives = 45/95 (47%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A ++G V+ + +G + + G PLH AA +E ++ LL A ++ +
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+T L A + GH KLLL K A+ + +G T
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT 400
Score = 40.0 bits (92), Expect = 4e-04
Identities = 26/75 (34%), Positives = 36/75 (48%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G++ V + +G +VN + G PLH AA G I+ LL GA NA + T L
Sbjct: 739 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Query: 73 LSAVYEGHVSCVKLL 87
A G++S V L
Sbjct: 799 AIAKRLGYISVVDTL 813
Score = 39.3 bits (90), Expect = 7e-04
Identities = 27/84 (32%), Positives = 36/84 (42%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K + ++ V G + E G P+H AA G L I+ LL GA + +
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGA 92
T L A G V V+ LL GA
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGA 488
Score = 39.3 bits (90), Expect = 7e-04
Identities = 30/91 (32%), Positives = 41/91 (45%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G L+ V + G + T G LH AA GQ+E++ LL GA ++A + TPL
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
A G V+LLL A +G T
Sbjct: 502 HIASRLGKTEIVQLLLQHMAHPDAATTNGYT 532
Score = 37.7 bits (86), Expect = 0.002
Identities = 23/65 (35%), Positives = 32/65 (49%)
Query: 39 LHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKG 98
LH AA CG + + LL K A+ NA + TPL A + + ++LL+ GA
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
Query: 99 PDGLT 103
GLT
Sbjct: 429 ESGLT 433
Score = 33.5 bits (75), Expect = 0.037
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 42 AADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDG 101
AA G L+ + L G DIN +++ + L A EGHV V+ LL +G+ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 102 LTAFE----ATDNQAIKALLQ 118
TA A + +K L++
Sbjct: 98 NTALHIASLAGQAEVVKVLVK 118
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 69.7 bits (169), Expect = 5e-13
Identities = 44/107 (41%), Positives = 57/107 (53%), Gaps = 1/107 (0%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A+ NGD DEV+ + K EDVN R PLH AA G EI+E L+L GA +NA D
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFE-ATDNQAIK 114
+TPL AV V++LL AD + + T A N+A+K
Sbjct: 75 LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVK 121
Score = 58.9 bits (141), Expect = 8e-10
Identities = 34/92 (36%), Positives = 52/92 (56%)
Query: 27 DVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKL 86
+VN + GR LH+AA G E+++ LL +GA+INA DK + A Y GH+ VKL
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
Query: 87 LLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
L+S GA+ T K T A + + ++++
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVK 223
Score = 55.5 bits (132), Expect = 9e-09
Identities = 28/82 (34%), Positives = 48/82 (58%)
Query: 12 NGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
+G + VK +++G ++N + R+ +H+AA G +E+++ L+ GA++ DK TP
Sbjct: 150 SGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTP 209
Query: 72 LLSAVYEGHVSCVKLLLSKGAD 93
L +A G +S VK LL G D
Sbjct: 210 LHAAASSGMISVVKYLLDLGVD 231
Score = 54.7 bits (130), Expect = 2e-08
Identities = 33/96 (34%), Positives = 47/96 (48%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67
WA G ++ VK V+ G +V + PLH AA G + ++++LL G D+N P+ +
Sbjct: 179 WAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAY 238
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
TPL A Y G V L+ GA K G T
Sbjct: 239 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274
Score = 50.4 bits (119), Expect = 3e-07
Identities = 34/101 (33%), Positives = 48/101 (47%), Gaps = 1/101 (0%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A +G + VK + G D+N G PLH A GQ ++ L+ GA +N ++
Sbjct: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKG 272
Query: 69 ITPLLSAVYEGH-VSCVKLLLSKGADKTVKGPDGLTAFEAT 108
TPL A H C++LL+ GAD +K DG T T
Sbjct: 273 FTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMT 313
Score = 50.4 bits (119), Expect = 3e-07
Identities = 28/81 (34%), Positives = 41/81 (50%)
Query: 22 VAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHV 81
V G DVN + G+ PLH A G+ + ++ GA I+ DK+ TPL A GH
Sbjct: 293 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352
Query: 82 SCVKLLLSKGADKTVKGPDGL 102
+ L++ GAD +G G+
Sbjct: 353 LLINTLITSGADTAKRGIHGM 373
Score = 48.5 bits (114), Expect = 1e-06
Identities = 38/108 (35%), Positives = 48/108 (44%), Gaps = 18/108 (16%)
Query: 18 VKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINA---PDKHHITPLLS 74
VKDY+ K R P+H AA G E L L+ NA D + TPL+
Sbjct: 611 VKDYILK-----------RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLML 659
Query: 75 AVYEGHVSCVKLLLSKGADKTVKGPDGLTAFE----ATDNQAIKALLQ 118
+V GH CV LL+KGA+ K G TA + + ALLQ
Sbjct: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQ 707
Score = 47.8 bits (112), Expect = 2e-06
Identities = 26/68 (38%), Positives = 37/68 (54%), Gaps = 4/68 (5%)
Query: 35 GRKPLHYAADCGQLEILEFLLLKGADINA----PDKHHITPLLSAVYEGHVSCVKLLLSK 90
GR P+H +A CG + +L LL A ++A D H T L A Y GH +CV+LLL +
Sbjct: 719 GRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ 778
Query: 91 GADKTVKG 98
+ +G
Sbjct: 779 EVFQKTEG 786
Score = 47.4 bits (111), Expect = 2e-06
Identities = 37/115 (32%), Positives = 52/115 (45%), Gaps = 5/115 (4%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A +G D + ++ G D++ + GR LH AA G LE L LL GAD N DK
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT-----AFEATDNQAIKALLQ 118
+PL A + C+ L+ GA G T A TD + ++ LL+
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLR 493
Score = 45.8 bits (107), Expect = 7e-06
Identities = 25/65 (38%), Positives = 35/65 (53%)
Query: 28 VNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLL 87
VN T GR PLH AA +E L+ LL A +N+ D TPL+ A G + V++L
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Query: 88 LSKGA 92
+S +
Sbjct: 876 VSSAS 880
Score = 44.7 bits (104), Expect = 2e-05
Identities = 29/84 (34%), Positives = 39/84 (46%)
Query: 18 VKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVY 77
+ + G D + G PLH AA G + LL G DI+ PD T L +A
Sbjct: 355 INTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAA 414
Query: 78 EGHVSCVKLLLSKGADKTVKGPDG 101
G++ C+ LLL+ GAD K G
Sbjct: 415 GGNLECLNLLLNTGADFNKKDKFG 438
Score = 44.7 bits (104), Expect = 2e-05
Identities = 24/60 (40%), Positives = 35/60 (58%)
Query: 38 PLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVK 97
PLH AA G + LE L+ D++ + TPL A ++GHV CV +L+++GA VK
Sbjct: 553 PLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVK 612
Score = 40.4 bits (93), Expect = 3e-04
Identities = 27/96 (28%), Positives = 38/96 (39%)
Query: 12 NGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
+G + + G ++ + G PLH AA G ++ L+ GAD H + P
Sbjct: 316 HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFP 375
Query: 72 LLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEA 107
L A G C + LLS G D G T A
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHA 411
Score = 40.0 bits (92), Expect = 4e-04
Identities = 29/85 (34%), Positives = 39/85 (45%), Gaps = 1/85 (1%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEI-LEFLLLKGADINAPDKH 67
A NG V + + G VN+ E G PLH+AA + LE L+ GAD+N K
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGA 92
TPL G S + ++ GA
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGA 330
Score = 38.9 bits (89), Expect = 9e-04
Identities = 27/86 (31%), Positives = 39/86 (45%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M ++ NG D V + KG +V+ + GR LH A G E ++ LL GA D
Sbjct: 658 MLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDS 717
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGA 92
TP+ + GH+ + LL A
Sbjct: 718 RGRTPIHLSAACGHIGVLGALLQSAA 743
Score = 38.5 bits (88), Expect = 0.001
Identities = 24/69 (34%), Positives = 33/69 (47%)
Query: 35 GRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
G+ PL + G + + LL KGA+++A DK T L GH CV LL GA
Sbjct: 653 GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKC 712
Query: 95 TVKGPDGLT 103
++ G T
Sbjct: 713 LLRDSRGRT 721
Score = 37.7 bits (86), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 1/92 (1%)
Query: 22 VAKGEDVNRTLEGGRKPLHYAADCG-QLEILEFLLLKGADINAPDKHHITPLLSAVYEGH 80
V G VN E G PLHYAA + LE+LL A+ DK + + GH
Sbjct: 458 VGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH 517
Query: 81 VSCVKLLLSKGADKTVKGPDGLTAFEATDNQA 112
C++L+ S+ + G +DN+A
Sbjct: 518 RLCLQLIASETPLDVLMETSGTDMLSDSDNRA 549
Score = 35.4 bits (80), Expect = 0.010
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 28 VNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVS-CVKL 86
+N T + PLH AA G +++ LL KGA + A D++ TP L+ V+ C+ L
Sbjct: 919 INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLAL 978
Query: 87 LLSKGADKTVKGPDGLTAFEA 107
+L+ + P F A
Sbjct: 979 ILATMMPVSSSSPLSSLTFNA 999
Score = 27.3 bits (59), Expect = 2.6
Identities = 20/84 (23%), Positives = 37/84 (44%), Gaps = 12/84 (14%)
Query: 35 GRKPLHYAADCGQLEILEFLLLK----------GADI--NAPDKHHITPLLSAVYEGHVS 82
G +HY+A G L+ + + G D+ ++ ++ I+PL A Y GH
Sbjct: 505 GYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ 564
Query: 83 CVKLLLSKGADKTVKGPDGLTAFE 106
+++L+ D V+ G T +
Sbjct: 565 ALEVLVQSLLDLDVRNSSGRTPLD 588
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 67.4 bits (163), Expect = 2e-12
Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 1/102 (0%)
Query: 17 EVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSA 75
EV +Y+ + G DVN +GG PLH AA G +++ L+ A +NA DK TPL A
Sbjct: 693 EVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEA 752
Query: 76 VYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
+G LLL+ GAD T+K +G T + + ALL
Sbjct: 753 AQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 66.6 bits (161), Expect = 4e-12
Identities = 40/105 (38%), Positives = 55/105 (52%), Gaps = 1/105 (0%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G D V+ + G +V +GG PLH A G E++ LL GAD NA D + TPL
Sbjct: 69 GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
A +G + +LL GA+ T++ DG TA + D A KA+L
Sbjct: 129 HEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA-KAVL 172
Score = 65.5 bits (158), Expect = 9e-12
Identities = 39/96 (40%), Positives = 54/96 (56%), Gaps = 3/96 (3%)
Query: 4 KEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRK--PLHYAADCGQLEILEFLLLKGADI 61
+E A +NGD++ VK V E VN GRK PLH+AA G+ +++E+LL GA++
Sbjct: 26 RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84
Query: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVK 97
A D + PL +A GH V LLL GAD +
Sbjct: 85 QARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR 120
Score = 59.7 bits (143), Expect = 5e-10
Identities = 33/91 (36%), Positives = 52/91 (57%), Gaps = 1/91 (1%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRK-PLHYAADCGQLEILEFLLLKGADI 61
D++ + A K GD++ VK R +EG + PLH+AA ++ ++E+LL GAD+
Sbjct: 493 DRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Query: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSKGA 92
+A DK + PL +A GH +LL+ GA
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGA 583
Score = 59.7 bits (143), Expect = 5e-10
Identities = 34/82 (41%), Positives = 41/82 (50%)
Query: 25 GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCV 84
G DV+ +GG PLH A G E+ E L+ GA +N D TPL A +G
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEIC 608
Query: 85 KLLLSKGADKTVKGPDGLTAFE 106
KLLL GAD T K DG T +
Sbjct: 609 KLLLQHGADPTKKNRDGNTPLD 630
Score = 53.1 bits (126), Expect = 4e-08
Identities = 33/93 (35%), Positives = 43/93 (46%)
Query: 25 GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCV 84
G DV+ +G PLH A G E+ E L+ GA +NA D TPL A + V
Sbjct: 234 GADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVC 293
Query: 85 KLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
LLLS GAD T+ +A + +K L
Sbjct: 294 SLLLSYGADPTLLNCHNKSAIDLAPTPQLKERL 326
Score = 51.2 bits (121), Expect = 2e-07
Identities = 31/95 (32%), Positives = 49/95 (51%), Gaps = 1/95 (1%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
KG ++N + PLH A++ +++E ++ A +NA D T L A Y GH+
Sbjct: 389 KGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQT 448
Query: 84 VKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
+LLLS G D + G TA + N+ ++ LLQ
Sbjct: 449 CRLLLSYGCDPNIISLQGFTALQ-MGNENVQQLLQ 482
Score = 49.7 bits (117), Expect = 5e-07
Identities = 28/68 (41%), Positives = 40/68 (58%), Gaps = 2/68 (2%)
Query: 27 DVNRTLEGGRK--PLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCV 84
+VN GRK PLH AA +++I++ LL GAD++A DK + PL +A GH
Sbjct: 201 NVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVT 260
Query: 85 KLLLSKGA 92
+LL+ GA
Sbjct: 261 ELLVKHGA 268
Score = 30.0 bits (66), Expect = 0.41
Identities = 20/64 (31%), Positives = 28/64 (43%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A G +D + VN T + PLH AA G+ ++ LL GAD ++
Sbjct: 719 AASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEG 778
Query: 69 ITPL 72
TPL
Sbjct: 779 QTPL 782
Score = 28.9 bits (63), Expect = 0.91
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 1/48 (2%)
Query: 16 DEVKDYVAKGEDVNRTLEG-GRKPLHYAADCGQLEILEFLLLKGADIN 62
++V + V K E L+ G+ LH AA CG L+ LL G D N
Sbjct: 413 NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPN 460
Score = 26.2 bits (56), Expect = 5.9
Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 4/95 (4%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLL-LKGADINAPDKH 67
AL+ G+ + V+ + +G + + E R+ L AA G +E ++ L ++ + +
Sbjct: 469 ALQMGN-ENVQQLLQEGISLGNS-EADRQLLE-AAKAGDVETVKKLCTVQSVNCRDIEGR 525
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGL 102
TPL A VS V+ LL GAD K GL
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGL 560
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 67.0 bits (162), Expect = 3e-12
Identities = 40/102 (39%), Positives = 54/102 (52%), Gaps = 1/102 (0%)
Query: 17 EVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSA 75
EV +Y+ + G DVN +GG PLH AA G ++I L+ +NA DK TPL A
Sbjct: 851 EVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEA 910
Query: 76 VYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
+G LLL+ GAD T+K +G T + I+ALL
Sbjct: 911 AQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALL 952
Score = 66.6 bits (161), Expect = 4e-12
Identities = 39/105 (37%), Positives = 56/105 (53%), Gaps = 1/105 (0%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G D V+ + G +V+ +GG PLH A G E++ LL +GAD NA D + TPL
Sbjct: 227 GRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPL 286
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
A +G + +LL GAD ++ DG +A + D A KA+L
Sbjct: 287 HEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSA-KAVL 330
Score = 62.8 bits (151), Expect = 6e-11
Identities = 38/96 (39%), Positives = 55/96 (57%), Gaps = 3/96 (3%)
Query: 4 KEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRK--PLHYAADCGQLEILEFLLLKGADI 61
+E + A +NGD+ VK V +VN GRK PLH+AA G+ +++E LL GA++
Sbjct: 184 RELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
Query: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVK 97
+A D + PL +A GH V LLL +GAD +
Sbjct: 243 HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR 278
Score = 60.8 bits (146), Expect = 2e-10
Identities = 38/96 (39%), Positives = 55/96 (57%), Gaps = 3/96 (3%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVN-RTLEGGRK-PLHYAADCGQLEILEFLLLKGAD 60
D + A K GDL+ VK + ++VN R LEG PLH+AA ++ ++E+LL GAD
Sbjct: 651 DYRLLEASKAGDLETVKQ-LCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD 709
Query: 61 INAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTV 96
++A DK + PL +A GH +LL+ GA V
Sbjct: 710 VHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV 745
Score = 60.8 bits (146), Expect = 2e-10
Identities = 34/82 (41%), Positives = 41/82 (50%)
Query: 25 GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCV 84
G DV+ +GG PLH A G E+ E L+ GA +N D TPL A +G
Sbjct: 707 GADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEIC 766
Query: 85 KLLLSKGADKTVKGPDGLTAFE 106
KLLL GAD T K DG T +
Sbjct: 767 KLLLKHGADPTKKNRDGNTPLD 788
Score = 58.2 bits (139), Expect = 1e-09
Identities = 35/93 (37%), Positives = 45/93 (48%)
Query: 25 GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCV 84
G DV+ +GG PLH A G E+ E LL GA +NA D TPL A + V
Sbjct: 392 GADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVC 451
Query: 85 KLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
LLLS GAD T+ G +A + ++ L
Sbjct: 452 SLLLSHGADPTLVNCHGKSAVDMAPTPELRERL 484
Score = 52.4 bits (124), Expect = 8e-08
Identities = 33/94 (35%), Positives = 50/94 (53%), Gaps = 1/94 (1%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
KG +VN + PLH AA+ +++E L GA +NA D T L A GH+
Sbjct: 547 KGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQT 606
Query: 84 VKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
+LLLS G+D ++ G TA + N+A++ +L
Sbjct: 607 CRLLLSYGSDPSIISLQGFTAAQ-MGNEAVQQIL 639
Score = 50.1 bits (118), Expect = 4e-07
Identities = 29/68 (42%), Positives = 39/68 (57%), Gaps = 2/68 (2%)
Query: 27 DVNRTLEGGRK--PLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCV 84
+VN GRK PLH AA ++ I++ LL GAD++A DK + PL +A GH
Sbjct: 359 NVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVT 418
Query: 85 KLLLSKGA 92
+LLL GA
Sbjct: 419 ELLLKHGA 426
Score = 33.9 bits (76), Expect = 0.028
Identities = 19/56 (33%), Positives = 28/56 (50%)
Query: 49 EILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
++ E LL KGA++N +K +TPL A H +++L GA G TA
Sbjct: 539 QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTA 594
Score = 29.3 bits (64), Expect = 0.70
Identities = 23/63 (36%), Positives = 29/63 (46%), Gaps = 3/63 (4%)
Query: 42 AADCGQLEILEFLLLKGADINAPDKH--HITPLLSAVYEGHVSCVKLLLSKGADKTVKGP 99
A+ G LE ++ L ++N D H TPL A VS V+ LL GAD K
Sbjct: 657 ASKAGDLETVK-QLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDK 715
Query: 100 DGL 102
GL
Sbjct: 716 GGL 718
Score = 28.9 bits (63), Expect = 0.91
Identities = 30/94 (31%), Positives = 36/94 (38%), Gaps = 1/94 (1%)
Query: 10 LKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLK-GADINAPDKHH 68
++N D D T E + L AA G E L LL + +A D
Sbjct: 310 IRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRK 369
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGL 102
TPL A V V+LLL GAD K GL
Sbjct: 370 STPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 66.6 bits (161), Expect = 4e-12
Identities = 39/105 (37%), Positives = 56/105 (53%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
GD+ V+ + G D N G PLH A + G L+++E LL A +N + +PL
Sbjct: 439 GDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPL 498
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
A GHV VKLLLS GA + GL + TD++++K+LL
Sbjct: 499 HDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 66.2 bits (160), Expect = 5e-12
Identities = 36/114 (31%), Positives = 61/114 (53%), Gaps = 4/114 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G ++ V + + + +V+ + G LH A+ GQ E+++ L+ GA++NA ++
Sbjct: 81 ASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNG 140
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
TPL A E H+ VK LL GA +++ DG T A + +Q + LL+
Sbjct: 141 FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE 194
Score = 55.8 bits (133), Expect = 7e-09
Identities = 37/106 (34%), Positives = 50/106 (47%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G + VK V G +VN + G PL+ AA LE+++FLL GA + + TPL
Sbjct: 118 GQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL 177
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
A+ +GH V LLL V+ P A D +A LLQ
Sbjct: 178 AVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
Score = 54.3 bits (129), Expect = 2e-08
Identities = 36/108 (33%), Positives = 46/108 (42%), Gaps = 3/108 (2%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G D V+ + +G N G PLH +A G ++ FLL GA ++ K TPL
Sbjct: 510 GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEAT---DNQAIKALL 117
A G + LLL K A G GLT DNQ + LL
Sbjct: 570 HVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Score = 52.0 bits (123), Expect = 1e-07
Identities = 30/80 (37%), Positives = 40/80 (50%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
+G + + G PLH AA Q++I LL GAD NA + I + A EGHV
Sbjct: 620 QGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDM 679
Query: 84 VKLLLSKGADKTVKGPDGLT 103
V LLL + A+ + GLT
Sbjct: 680 VSLLLGRNANVNLSNKSGLT 699
Score = 50.8 bits (120), Expect = 2e-07
Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 4/114 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + G +D V + + +VN + + G PLH AA ++ + E L+ +GA ++A K
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQA----IKALLQ 118
TPL + G++ V LL A K +G T Q I LLQ
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 784
Score = 50.4 bits (119), Expect = 3e-07
Identities = 30/95 (31%), Positives = 45/95 (47%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A ++G + V+ V G V + + PLH +A G+ +I++ LL +GA NA
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
TPL + EGH LL GA ++ G T
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFT 567
Score = 49.7 bits (117), Expect = 5e-07
Identities = 28/71 (39%), Positives = 39/71 (54%)
Query: 33 EGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGA 92
+ G PLH AA G + + LL + A ++ ++ ITPL A G+ + VKLLL +GA
Sbjct: 233 KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA 292
Query: 93 DKTVKGPDGLT 103
K DGLT
Sbjct: 293 KIDAKTRDGLT 303
Score = 49.7 bits (117), Expect = 5e-07
Identities = 31/96 (32%), Positives = 48/96 (50%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G+ + VK + +G ++ G PLH A G +++E LL + A I + K+
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 334
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
++PL A H++CV+LLL D LTA
Sbjct: 335 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTA 370
Score = 49.7 bits (117), Expect = 5e-07
Identities = 28/83 (33%), Positives = 40/83 (48%)
Query: 22 VAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHV 81
V +G V+ + G PLH G ++I+ FLL A +NA K+ TPL A +GH
Sbjct: 717 VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHT 776
Query: 82 SCVKLLLSKGADKTVKGPDGLTA 104
+ +LL A +G TA
Sbjct: 777 HIINVLLQNNASPNELTVNGNTA 799
Score = 47.0 bits (110), Expect = 3e-06
Identities = 29/92 (31%), Positives = 42/92 (45%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G K + K + N G PLH A +++++E LL GA I A + +TP+
Sbjct: 378 GHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPI 437
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
A + GHV+ V L+ GA G TA
Sbjct: 438 HVAAFMGHVNIVSQLMHHGASPNTTNVRGETA 469
Score = 47.0 bits (110), Expect = 3e-06
Identities = 27/95 (28%), Positives = 46/95 (48%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K +D + G D N G +H AA G ++++ LL + A++N +K
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+TPL A E V+ ++L+++GA + G T
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYT 732
Score = 46.6 bits (109), Expect = 4e-06
Identities = 30/93 (32%), Positives = 43/93 (46%)
Query: 11 KNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHIT 70
+ G D + G ++ T + G PLH AA G+LE+ LL K A +A K +T
Sbjct: 541 REGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLT 600
Query: 71 PLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
PL A + + LLL +GA +G T
Sbjct: 601 PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
Score = 45.8 bits (107), Expect = 7e-06
Identities = 29/91 (31%), Positives = 40/91 (43%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
G ++ V + G N T G LH AA GQ E++ +L+ GA + A K TPL
Sbjct: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL 503
Query: 73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+ G V+ LL +GA G T
Sbjct: 504 HISARLGKADIVQQLLQQGASPNAATTSGYT 534
Score = 43.1 bits (100), Expect = 5e-05
Identities = 25/76 (32%), Positives = 39/76 (51%)
Query: 28 VNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLL 87
V+ T PLH A+ G +++ LL +GA I+A + +TPL GH V++L
Sbjct: 261 VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320
Query: 88 LSKGADKTVKGPDGLT 103
L + A K +GL+
Sbjct: 321 LDRAAPILSKTKNGLS 336
Score = 40.0 bits (92), Expect = 4e-04
Identities = 24/65 (36%), Positives = 33/65 (50%)
Query: 39 LHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKG 98
LH AA CG ++ + LL K A+ NA + TPL A + + ++LLL GA
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430
Query: 99 PDGLT 103
GLT
Sbjct: 431 ESGLT 435
Score = 39.7 bits (91), Expect = 5e-04
Identities = 26/95 (27%), Positives = 38/95 (40%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K + ++ + G + E G P+H AA G + I+ L+ GA N +
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
T L A G V+ L+ GA K D T
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT 501
Score = 38.1 bits (87), Expect = 0.001
Identities = 21/71 (29%), Positives = 32/71 (45%)
Query: 33 EGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGA 92
+ G PLH A L ++ LL ++ ++T L A + GH K+LL K A
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 93 DKTVKGPDGLT 103
+ K +G T
Sbjct: 392 NPNAKALNGFT 402
Score = 31.2 bits (69), Expect = 0.18
Identities = 22/63 (34%), Positives = 29/63 (46%)
Query: 42 AADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDG 101
AA G LE + G DIN +++ + L A EGHV V LL + A+ G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 102 LTA 104
TA
Sbjct: 108 NTA 110
Score = 26.9 bits (58), Expect = 3.5
Identities = 16/54 (29%), Positives = 25/54 (46%)
Query: 39 LHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGA 92
LH AA + LL + + K TPL A + G+++ LLL++ A
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAA 259
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 65.9 bits (159), Expect = 7e-12
Identities = 40/116 (34%), Positives = 63/116 (54%), Gaps = 4/116 (3%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
MWA G D V+ ++ G + + T P+ +AA G +I+ LL GA +N DK
Sbjct: 109 MWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDK 168
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAF----EATDNQAIKALLQ 118
+ TPL+ A +GH+ CVK LL+ GAD +G + +TA + Q++K +L+
Sbjct: 169 YGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
Score = 62.0 bits (149), Expect = 1e-10
Identities = 37/96 (38%), Positives = 52/96 (54%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A+K G VK+ + + +VN T + G L A+ G EI++ LL G +N PD+
Sbjct: 210 AVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSG 269
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
T L+ AV GHV V+ LL K AD ++G D TA
Sbjct: 270 DTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTA 305
Score = 53.9 bits (128), Expect = 3e-08
Identities = 34/91 (37%), Positives = 51/91 (56%)
Query: 14 DLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLL 73
++ +K + K +DV+ E G+ PL AA+ G LEI++ L+ GA+ N D + T L+
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 74 SAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
SA EGHV V+ LL G + + G TA
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTA 107
Score = 45.4 bits (106), Expect = 9e-06
Identities = 28/86 (32%), Positives = 41/86 (47%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67
WA++ G+ V+D + D + G PL A +E++E LL KGA ++A DK
Sbjct: 308 WAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKK 367
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGAD 93
TPL A+ +LLL D
Sbjct: 368 GDTPLHIAIRGRSRKLAELLLRNPKD 393
Score = 42.0 bits (97), Expect = 1e-04
Identities = 27/95 (28%), Positives = 44/95 (46%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A K G + V++ + G ++ GG L +A G+ +++E LL GA+ + +
Sbjct: 78 ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+ P++ A GH V LLL GA G T
Sbjct: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTT 172
Score = 39.7 bits (91), Expect = 5e-04
Identities = 32/97 (32%), Positives = 46/97 (47%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A K G + V+D + G VN G L A G +EI+ LL K ADI+ +
Sbjct: 241 MIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQ 300
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+ T L AV +G+ + V+ +L D + DG T
Sbjct: 301 DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGET 337
Score = 37.4 bits (85), Expect = 0.003
Identities = 23/90 (25%), Positives = 44/90 (48%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D + A++ G ++ V+ + K D++ + + L++A + G ++ +L D
Sbjct: 270 DTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTE 329
Query: 63 APDKHHITPLLSAVYEGHVSCVKLLLSKGA 92
K TPL+ A ++ V+LLL KGA
Sbjct: 330 ICTKDGETPLIKATKMRNIEVVELLLDKGA 359
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 65.1 bits (157), Expect = 1e-11
Identities = 41/110 (37%), Positives = 59/110 (53%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A G L+ + + G V+RT G PL AA G +I+ LL +G D+N DK
Sbjct: 1078 AAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQG 1137
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
TPL+ A EGH+S V+ LLSKGA + +GL+A + +A++Q
Sbjct: 1138 RTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQ 1187
Score = 55.5 bits (132), Expect = 9e-09
Identities = 38/102 (37%), Positives = 56/102 (54%), Gaps = 5/102 (4%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + G V+ + +G DVN + + GR PL AA G L +EFLL KGA +++ DK
Sbjct: 1111 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1170
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGA-----DKTVKGPDGLTAF 105
++ L A +GH + V+ L+ +GA DK + P L AF
Sbjct: 1171 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAF 1212
Score = 46.6 bits (109), Expect = 4e-06
Identities = 25/69 (36%), Positives = 36/69 (52%)
Query: 35 GRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
G L AA G+LE+ E LL GA ++ ++ + PL A +GH V+LLL +G D
Sbjct: 1071 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 1130
Query: 95 TVKGPDGLT 103
+ G T
Sbjct: 1131 NLSDKQGRT 1139
Score = 45.1 bits (105), Expect = 1e-05
Identities = 31/85 (36%), Positives = 43/85 (50%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67
WA G V+ V +G +++T + GR PL AA G E + +L+ KGA I D
Sbjct: 1176 WACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHS 1235
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGA 92
+ PL A+ + S V LL KGA
Sbjct: 1236 GMRPLDRAIGCRNTSVVVALLRKGA 1260
Score = 40.8 bits (94), Expect = 2e-04
Identities = 27/86 (31%), Positives = 44/86 (51%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A G L V+ ++KG ++ + G L +A G ++++L+ +GA I+ DK
Sbjct: 1142 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1201
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGA 92
+ TPL A + G V L+ KGA
Sbjct: 1202 NGRTPLDLAAFYGDAETVLYLVEKGA 1227
Score = 32.0 bits (71), Expect = 0.11
Identities = 19/65 (29%), Positives = 32/65 (49%)
Query: 25 GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCV 84
G ++ T E G L YAA G ++++ L KG ++ DK L+ + GH +
Sbjct: 950 GACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDIL 1009
Query: 85 KLLLS 89
+ LL+
Sbjct: 1010 QYLLT 1014
Score = 29.3 bits (64), Expect = 0.70
Identities = 16/49 (32%), Positives = 22/49 (44%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADI 61
GD + V V KG + G +PL A C ++ LL KGA +
Sbjct: 1214 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
Score = 28.5 bits (62), Expect = 1.2
Identities = 16/46 (34%), Positives = 24/46 (52%)
Query: 46 GQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKG 91
G E++ LL GA ++ ++ +T L A GH+ V LL KG
Sbjct: 938 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKG 983
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 65.1 bits (157), Expect = 1e-11
Identities = 41/110 (37%), Positives = 59/110 (53%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A G L+ + + G V+RT G PL AA G +I+ LL +G D+N DK
Sbjct: 1086 AAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQG 1145
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
TPL+ A EGH+S V+ LLSKGA + +GL+A + +A++Q
Sbjct: 1146 RTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQ 1195
Score = 55.5 bits (132), Expect = 9e-09
Identities = 38/102 (37%), Positives = 56/102 (54%), Gaps = 5/102 (4%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + G V+ + +G DVN + + GR PL AA G L +EFLL KGA +++ DK
Sbjct: 1119 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1178
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGA-----DKTVKGPDGLTAF 105
++ L A +GH + V+ L+ +GA DK + P L AF
Sbjct: 1179 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAF 1220
Score = 46.6 bits (109), Expect = 4e-06
Identities = 25/69 (36%), Positives = 36/69 (52%)
Query: 35 GRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
G L AA G+LE+ E LL GA ++ ++ + PL A +GH V+LLL +G D
Sbjct: 1079 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 1138
Query: 95 TVKGPDGLT 103
+ G T
Sbjct: 1139 NLSDKQGRT 1147
Score = 45.1 bits (105), Expect = 1e-05
Identities = 31/85 (36%), Positives = 43/85 (50%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67
WA G V+ V +G +++T + GR PL AA G E + +L+ KGA I D
Sbjct: 1184 WACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHS 1243
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGA 92
+ PL A+ + S V LL KGA
Sbjct: 1244 GMRPLDRAIGCRNTSVVVALLRKGA 1268
Score = 40.8 bits (94), Expect = 2e-04
Identities = 27/86 (31%), Positives = 44/86 (51%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A G L V+ ++KG ++ + G L +A G ++++L+ +GA I+ DK
Sbjct: 1150 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1209
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGA 92
+ TPL A + G V L+ KGA
Sbjct: 1210 NGRTPLDLAAFYGDAETVLYLVEKGA 1235
Score = 32.0 bits (71), Expect = 0.11
Identities = 19/65 (29%), Positives = 32/65 (49%)
Query: 25 GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCV 84
G ++ T E G L YAA G ++++ L KG ++ DK L+ + GH +
Sbjct: 958 GACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDIL 1017
Query: 85 KLLLS 89
+ LL+
Sbjct: 1018 QYLLT 1022
Score = 29.3 bits (64), Expect = 0.70
Identities = 16/49 (32%), Positives = 22/49 (44%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADI 61
GD + V V KG + G +PL A C ++ LL KGA +
Sbjct: 1222 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
Score = 28.5 bits (62), Expect = 1.2
Identities = 16/46 (34%), Positives = 24/46 (52%)
Query: 46 GQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKG 91
G E++ LL GA ++ ++ +T L A GH+ V LL KG
Sbjct: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKG 991
>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 65.1 bits (157), Expect = 1e-11
Identities = 37/110 (33%), Positives = 58/110 (52%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A++ G+L VK + G DVN G PLH A++ G ++I+ LL GA +N +
Sbjct: 1162 AVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDG 1221
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
I PL AV H+ ++LL GA+ K +A + D++ +K LL+
Sbjct: 1222 ILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLR 1271
Score = 61.6 bits (148), Expect = 1e-10
Identities = 39/110 (35%), Positives = 52/110 (47%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + D D V + KG +VN+ G LH A+ G LL GAD+N +
Sbjct: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
ITPL AV GH +LLL GAD + DG A + + +K LL+
Sbjct: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLE 605
Score = 46.6 bits (109), Expect = 4e-06
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
K +N+ G LH A G L +++ L+ GAD+N D TPL A EG +
Sbjct: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
Query: 84 VKLLLSKGADKTVKGPDG-LTAFEATDNQAIKA 115
+ LL GA + DG L +A N +KA
Sbjct: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
Score = 30.0 bits (66), Expect = 0.41
Identities = 22/87 (25%), Positives = 36/87 (41%)
Query: 12 NGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
+G +++K +NR G ++ AA +++ + KG ++N P T
Sbjct: 466 SGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTA 525
Query: 72 LLSAVYEGHVSCVKLLLSKGADKTVKG 98
L A G LL GAD +KG
Sbjct: 526 LHEASVGGFYRTASELLKGGADVNIKG 552
>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 65.1 bits (157), Expect = 1e-11
Identities = 37/110 (33%), Positives = 58/110 (52%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A++ G+L VK + G DVN G PLH A++ G ++I+ LL GA +N +
Sbjct: 1162 AVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDG 1221
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
I PL AV H+ ++LL GA+ K +A + D++ +K LL+
Sbjct: 1222 ILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLR 1271
Score = 61.6 bits (148), Expect = 1e-10
Identities = 39/110 (35%), Positives = 52/110 (47%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + D D V + KG +VN+ G LH A+ G LL GAD+N +
Sbjct: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
ITPL AV GH +LLL GAD + DG A + + +K LL+
Sbjct: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLE 605
Score = 46.6 bits (109), Expect = 4e-06
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
K +N+ G LH A G L +++ L+ GAD+N D TPL A EG +
Sbjct: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
Query: 84 VKLLLSKGADKTVKGPDG-LTAFEATDNQAIKA 115
+ LL GA + DG L +A N +KA
Sbjct: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
Score = 30.0 bits (66), Expect = 0.41
Identities = 22/87 (25%), Positives = 36/87 (41%)
Query: 12 NGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
+G +++K +NR G ++ AA +++ + KG ++N P T
Sbjct: 466 SGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTA 525
Query: 72 LLSAVYEGHVSCVKLLLSKGADKTVKG 98
L A G LL GAD +KG
Sbjct: 526 LHEASVGGFYRTASELLKGGADVNIKG 552
>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 65.1 bits (157), Expect = 1e-11
Identities = 37/110 (33%), Positives = 58/110 (52%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A++ G+L VK + G DVN G PLH A++ G ++I+ LL GA +N +
Sbjct: 1162 AVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDG 1221
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
I PL AV H+ ++LL GA+ K +A + D++ +K LL+
Sbjct: 1222 ILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEADDEKMKELLR 1271
Score = 61.6 bits (148), Expect = 1e-10
Identities = 39/110 (35%), Positives = 52/110 (47%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + D D V + KG +VN+ G LH A+ G LL GAD+N +
Sbjct: 496 AALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQ 555
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
ITPL AV GH +LLL GAD + DG A + + +K LL+
Sbjct: 556 ITPLHDAVMNGHYKVAELLLLNGADPLFRNDDGKCALDEAKDLCMKRLLE 605
Score = 46.6 bits (109), Expect = 4e-06
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Query: 24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC 83
K +N+ G LH A G L +++ L+ GAD+N D TPL A EG +
Sbjct: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDI 1203
Query: 84 VKLLLSKGADKTVKGPDG-LTAFEATDNQAIKA 115
+ LL GA + DG L +A N +KA
Sbjct: 1204 IVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
Score = 30.0 bits (66), Expect = 0.41
Identities = 22/87 (25%), Positives = 36/87 (41%)
Query: 12 NGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
+G +++K +NR G ++ AA +++ + KG ++N P T
Sbjct: 466 SGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTA 525
Query: 72 LLSAVYEGHVSCVKLLLSKGADKTVKG 98
L A G LL GAD +KG
Sbjct: 526 LHEASVGGFYRTASELLKGGADVNIKG 552
>gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo
sapiens]
Length = 313
Score = 64.7 bits (156), Expect = 1e-11
Identities = 36/100 (36%), Positives = 52/100 (52%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
MWA +G + V+ + G D +G L A G +I++ LL G D+N D
Sbjct: 187 MWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDW 246
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFE 106
+ TPLL AV+ HV CVK+LL GAD T++ G + +
Sbjct: 247 NGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMD 286
Score = 34.7 bits (78), Expect = 0.017
Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 24 KGEDVNRT-LEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVS 82
+G +V+ T L +H A G++ L + + IN D+ TPL+ A G ++
Sbjct: 137 RGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIA 196
Query: 83 CVKLLLSKGADKTVKG 98
V+ LL GAD + G
Sbjct: 197 VVEFLLQNGADPQLLG 212
>gi|10863929 ribonuclease L [Homo sapiens]
Length = 741
Score = 63.2 bits (152), Expect = 4e-11
Identities = 45/110 (40%), Positives = 59/110 (53%), Gaps = 2/110 (1%)
Query: 9 ALKNGDLDEVKDYVAKGEDVN-RTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67
A++N D+D V+ + G +VN + EGG PLH A + +I+E LL GAD K+
Sbjct: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAF-EATDNQAIKAL 116
TP + A G V +KL LSKGAD G TAF EA +KAL
Sbjct: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKAL 141
Score = 44.3 bits (103), Expect = 2e-05
Identities = 33/83 (39%), Positives = 44/83 (53%), Gaps = 5/83 (6%)
Query: 26 EDVNRTLEGGRKPLHYAADCGQLEILEFLLLK-GADINAPDKHHITPLLSAVYEGHVSCV 84
ED R +GG L AA+ G +E+L+ LL + GAD+NA D L+ A+ S V
Sbjct: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218
Query: 85 K----LLLSKGADKTVKGPDGLT 103
+ LLL GAD V+G G T
Sbjct: 219 EAITHLLLDHGADVNVRGERGKT 241
Score = 43.5 bits (101), Expect = 4e-05
Identities = 25/82 (30%), Positives = 40/82 (48%)
Query: 16 DEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSA 75
D V+ + G D + G P AA G +++L+ L KGAD+N D + T + A
Sbjct: 73 DIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEA 132
Query: 76 VYEGHVSCVKLLLSKGADKTVK 97
G V +K L +GA+ ++
Sbjct: 133 AVYGKVKALKFLYKRGANVNLR 154
Score = 41.6 bits (96), Expect = 1e-04
Identities = 32/99 (32%), Positives = 50/99 (50%), Gaps = 11/99 (11%)
Query: 6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD 65
F+ A G + +K +++KG DVN G AA G+++ L+FL +GA++N
Sbjct: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155
Query: 66 KHH----------ITPLLSAVYEGHVSCVKLLLSK-GAD 93
K T L+ A +GHV +K+LL + GAD
Sbjct: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGAD 194
Score = 36.6 bits (83), Expect = 0.004
Identities = 30/89 (33%), Positives = 47/89 (52%), Gaps = 5/89 (5%)
Query: 7 MWALKNGDLDEVKDYVAK-GEDVNRTLEGGRKPLHYA---ADCGQLEILEFLLLK-GADI 61
M A + G ++ +K + + G DVN GR L +A +D +E + LLL GAD+
Sbjct: 173 MDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADV 232
Query: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSK 90
N + TPL+ AV + H+ V+ LL +
Sbjct: 233 NVRGERGKTPLILAVEKKHLGLVQRLLEQ 261
>gi|156142184 ankyrin repeat domain 39 [Homo sapiens]
Length = 183
Score = 63.2 bits (152), Expect = 4e-11
Identities = 37/96 (38%), Positives = 49/96 (51%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A NGDL VK + K ED ++ G LHYA+ G + +FLL GA +A
Sbjct: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
T L A Y GH +LLLS G++ V DG+T+
Sbjct: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTS 133
Score = 39.7 bits (91), Expect = 5e-04
Identities = 25/81 (30%), Positives = 34/81 (41%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67
+A +NG + + G + GG LH A+ CG EI LL G++ D
Sbjct: 70 YASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDD 129
Query: 68 HITPLLSAVYEGHVSCVKLLL 88
+T L A GH LLL
Sbjct: 130 GMTSLHKAAERGHGDICSLLL 150
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 62.8 bits (151), Expect = 6e-11
Identities = 35/113 (30%), Positives = 59/113 (52%)
Query: 6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD 65
F+ A +GD DEV + +G D+N G LH A +++++FL+ GA+IN PD
Sbjct: 44 FLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPD 103
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
PL +A G++ + L+ +GA +G T + + +A++ LLQ
Sbjct: 104 NEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156
Score = 45.4 bits (106), Expect = 9e-06
Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 27 DVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKL 86
DV GG LH AA G E+L+ L+ G D+N D TPL +A + G ++
Sbjct: 192 DVRHAKSGGTA-LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRI 250
Query: 87 LLSKGADKTVKGPDGLTAFEATDNQAI 113
L+ D + G TAF+ D +
Sbjct: 251 LVDNLCDMEMVNKVGQTAFDVADEDIL 277
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 62.8 bits (151), Expect = 6e-11
Identities = 35/113 (30%), Positives = 59/113 (52%)
Query: 6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD 65
F+ A +GD DEV + +G D+N G LH A +++++FL+ GA+IN PD
Sbjct: 44 FLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPD 103
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
PL +A G++ + L+ +GA +G T + + +A++ LLQ
Sbjct: 104 NEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156
Score = 45.4 bits (106), Expect = 9e-06
Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 27 DVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKL 86
DV GG LH AA G E+L+ L+ G D+N D TPL +A + G ++
Sbjct: 192 DVRHAKSGGTA-LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRI 250
Query: 87 LLSKGADKTVKGPDGLTAFEATDNQAI 113
L+ D + G TAF+ D +
Sbjct: 251 LVDNLCDMEMVNKVGQTAFDVADEDIL 277
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 62.8 bits (151), Expect = 6e-11
Identities = 40/104 (38%), Positives = 56/104 (53%), Gaps = 5/104 (4%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D +A +NG D + G D+ EGGR PL AA G L ++FL+ KGA++N
Sbjct: 569 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN 628
Query: 63 ---APDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
A + H + L A GH++ V+LLL+ GAD T + DG T
Sbjct: 629 RATANNDHTVVSLACA--GGHLAVVELLLAHGADPTHRLKDGST 670
Score = 59.3 bits (142), Expect = 6e-10
Identities = 33/92 (35%), Positives = 49/92 (53%)
Query: 2 CDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADI 61
C M A + G L+ VK +A G +V+ T G L YA + G ++ + LL GAD+
Sbjct: 535 CSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Query: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSKGAD 93
+ TPL+ A GH+ V+ L+SKGA+
Sbjct: 595 EHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626
Score = 51.2 bits (121), Expect = 2e-07
Identities = 34/98 (34%), Positives = 50/98 (51%), Gaps = 1/98 (1%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINA-PDK 66
+A G +D VK + +G ++ E G PL AA G +E+ LL GA IN ++
Sbjct: 311 YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE 370
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
+ L A Y+GH+ V+ LL GAD+ K + TA
Sbjct: 371 FKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTA 408
Score = 50.4 bits (119), Expect = 3e-07
Identities = 33/97 (34%), Positives = 50/97 (51%), Gaps = 1/97 (1%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADI-NAPDKH 67
A +GD++ V+ + +G VN E G L A G E+ + LL A++ + +K
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
ITPL++A G++ VKLLL AD + G TA
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 308
Score = 50.1 bits (118), Expect = 4e-07
Identities = 32/86 (37%), Positives = 45/86 (52%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A G LD VK + DVN G L YA G ++I++ LL +GA+I ++
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGA 92
+ TPL+ A GHV ++LL GA
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGA 362
Score = 50.1 bits (118), Expect = 4e-07
Identities = 23/69 (33%), Positives = 42/69 (60%)
Query: 22 VAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHV 81
+ +G ++ + G PL A++ G ++++ L+ GAD++A D ITPL+SA +GHV
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371
Query: 82 SCVKLLLSK 90
V+ L+ +
Sbjct: 1372 KVVQYLVKE 1380
Score = 49.3 bits (116), Expect = 6e-07
Identities = 28/87 (32%), Positives = 45/87 (51%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A +G ++ + + G VN + PL AA G +E+ L+ +GA++ +
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGAD 93
TPL+ A EGH V LLL++GA+
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGAN 496
Score = 48.1 bits (113), Expect = 1e-06
Identities = 33/85 (38%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Query: 12 NGDLDEVKDYV-AKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINA--PDKHH 68
+G EV D + A+G + PL AA G + I++ LL GA+IN+ K
Sbjct: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGAD 93
I+PL+ A GHV VKLLL G+D
Sbjct: 1191 ISPLMLAAMNGHVPAVKLLLDMGSD 1215
Score = 47.0 bits (110), Expect = 3e-06
Identities = 30/88 (34%), Positives = 45/88 (51%), Gaps = 1/88 (1%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKP-LHYAADCGQLEILEFLLLKGADINAPD 65
M A NG + VK + G D+N +E R L A G+ E++ LL + A++
Sbjct: 1195 MLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA 1254
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGAD 93
K +TPL+ A G+ ++LL KGAD
Sbjct: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGAD 1282
Score = 46.6 bits (109), Expect = 4e-06
Identities = 40/117 (34%), Positives = 55/117 (47%), Gaps = 8/117 (6%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQL-EILEFLLLKGADINAPD 65
M A + G + V +A+G ++N E ++ A CG E+ +FL+ GADI
Sbjct: 476 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC 535
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGAD---KTVKGPDGLT-AFEATDNQAIKALLQ 118
TPL+ A EGH+ VK LL+ GA+ T G LT A E LLQ
Sbjct: 536 S---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Score = 44.7 bits (104), Expect = 2e-05
Identities = 31/92 (33%), Positives = 44/92 (47%), Gaps = 4/92 (4%)
Query: 13 GDLDEVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
G EV D++ K G D+ G PL A+ G LE++++LL GA+++A T
Sbjct: 515 GGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTA 571
Query: 72 LLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
L A GH +LL GAD + G T
Sbjct: 572 LTYACENGHTDVADVLLQAGADLEHESEGGRT 603
Score = 43.9 bits (102), Expect = 3e-05
Identities = 29/95 (30%), Positives = 40/95 (42%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A G LD V+ + G D + L A G +E+ LL GA +N P
Sbjct: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 438
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+PL A GHV LL+ +GA+ +G T
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Score = 42.7 bits (99), Expect = 6e-05
Identities = 31/93 (33%), Positives = 44/93 (47%), Gaps = 1/93 (1%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D A G + V +A+ + + G PL AA G + ++E LL KG DI
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 63 AP-DKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
A ++ TPL A G V LLL++GA+K
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANK 1148
Score = 42.4 bits (98), Expect = 8e-05
Identities = 30/86 (34%), Positives = 39/86 (45%), Gaps = 2/86 (2%)
Query: 27 DVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAP--DKHHITPLLSAVYEGHVSCV 84
+V + G PL AA G E+ LL KGAD+NAP T L A +GH
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
Query: 85 KLLLSKGADKTVKGPDGLTAFEATDN 110
+LL+ +GA V+ G T N
Sbjct: 1309 ELLIHRGAHIDVRNKKGNTPLWLASN 1334
Score = 42.4 bits (98), Expect = 8e-05
Identities = 36/113 (31%), Positives = 50/113 (44%), Gaps = 13/113 (11%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKP--LHYAADCGQLEILEFLLLKGADINAP 64
M A G + + + KG DVN + L AAD G + E L+ +GA I+
Sbjct: 1262 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVR 1321
Query: 65 DKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
+K TPL A GH V+LL+ GAD +A DN+ I L+
Sbjct: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGAD-----------VDAADNRKITPLM 1363
Score = 41.6 bits (96), Expect = 1e-04
Identities = 26/82 (31%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRK-PLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
G + V+ + KG D+ E + PL A G+ E+++ LL +GA+ + TP
Sbjct: 1099 GHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTP 1158
Query: 72 LLSAVYEGHVSCVKLLLSKGAD 93
L A G+V+ +K+LL+ GA+
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAE 1180
Score = 40.4 bits (93), Expect = 3e-04
Identities = 25/65 (38%), Positives = 37/65 (56%)
Query: 29 NRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLL 88
+R +G PL A+ G L+I++ LLL AD+N+ T L A G V VK+LL
Sbjct: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 89 SKGAD 93
++GA+
Sbjct: 326 NEGAN 330
Score = 39.3 bits (90), Expect = 7e-04
Identities = 29/83 (34%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNR-TLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD 65
M A + G L V+ ++KG +VNR T + A G L ++E LL GAD
Sbjct: 606 MKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRL 665
Query: 66 KHHITPLLSAVYEGHVSCVKLLL 88
K T L+ A GH + V LL
Sbjct: 666 KDGSTMLIEAAKGGHTNVVSYLL 688
Score = 38.9 bits (89), Expect = 9e-04
Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 3/98 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEG--GRKPLHYAADCGQLEILEFLLLKGADINAP-D 65
A G ++ +K + G ++N G PL AA G + ++ LL G+DINA +
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE 1221
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+ T L A ++G V LLL + A+ + GLT
Sbjct: 1222 TNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLT 1259
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 62.8 bits (151), Expect = 6e-11
Identities = 40/104 (38%), Positives = 56/104 (53%), Gaps = 5/104 (4%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D +A +NG D + G D+ EGGR PL AA G L ++FL+ KGA++N
Sbjct: 569 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN 628
Query: 63 ---APDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
A + H + L A GH++ V+LLL+ GAD T + DG T
Sbjct: 629 RATANNDHTVVSLACA--GGHLAVVELLLAHGADPTHRLKDGST 670
Score = 59.3 bits (142), Expect = 6e-10
Identities = 33/92 (35%), Positives = 49/92 (53%)
Query: 2 CDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADI 61
C M A + G L+ VK +A G +V+ T G L YA + G ++ + LL GAD+
Sbjct: 535 CSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Query: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSKGAD 93
+ TPL+ A GH+ V+ L+SKGA+
Sbjct: 595 EHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626
Score = 51.2 bits (121), Expect = 2e-07
Identities = 34/98 (34%), Positives = 50/98 (51%), Gaps = 1/98 (1%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINA-PDK 66
+A G +D VK + +G ++ E G PL AA G +E+ LL GA IN ++
Sbjct: 311 YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE 370
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
+ L A Y+GH+ V+ LL GAD+ K + TA
Sbjct: 371 FKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTA 408
Score = 50.4 bits (119), Expect = 3e-07
Identities = 33/97 (34%), Positives = 50/97 (51%), Gaps = 1/97 (1%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADI-NAPDKH 67
A +GD++ V+ + +G VN E G L A G E+ + LL A++ + +K
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
ITPL++A G++ VKLLL AD + G TA
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 308
Score = 50.1 bits (118), Expect = 4e-07
Identities = 32/86 (37%), Positives = 45/86 (52%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A G LD VK + DVN G L YA G ++I++ LL +GA+I ++
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGA 92
+ TPL+ A GHV ++LL GA
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGA 362
Score = 50.1 bits (118), Expect = 4e-07
Identities = 23/69 (33%), Positives = 42/69 (60%)
Query: 22 VAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHV 81
+ +G ++ + G PL A++ G ++++ L+ GAD++A D ITPL+SA +GHV
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371
Query: 82 SCVKLLLSK 90
V+ L+ +
Sbjct: 1372 KVVQYLVKE 1380
Score = 49.3 bits (116), Expect = 6e-07
Identities = 28/87 (32%), Positives = 45/87 (51%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A +G ++ + + G VN + PL AA G +E+ L+ +GA++ +
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGAD 93
TPL+ A EGH V LLL++GA+
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGAN 496
Score = 48.1 bits (113), Expect = 1e-06
Identities = 33/85 (38%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Query: 12 NGDLDEVKDYV-AKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINA--PDKHH 68
+G EV D + A+G + PL AA G + I++ LL GA+IN+ K
Sbjct: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGAD 93
I+PL+ A GHV VKLLL G+D
Sbjct: 1191 ISPLMLAAMNGHVPAVKLLLDMGSD 1215
Score = 47.0 bits (110), Expect = 3e-06
Identities = 30/88 (34%), Positives = 45/88 (51%), Gaps = 1/88 (1%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKP-LHYAADCGQLEILEFLLLKGADINAPD 65
M A NG + VK + G D+N +E R L A G+ E++ LL + A++
Sbjct: 1195 MLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA 1254
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGAD 93
K +TPL+ A G+ ++LL KGAD
Sbjct: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGAD 1282
Score = 46.6 bits (109), Expect = 4e-06
Identities = 40/117 (34%), Positives = 55/117 (47%), Gaps = 8/117 (6%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQL-EILEFLLLKGADINAPD 65
M A + G + V +A+G ++N E ++ A CG E+ +FL+ GADI
Sbjct: 476 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC 535
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGAD---KTVKGPDGLT-AFEATDNQAIKALLQ 118
TPL+ A EGH+ VK LL+ GA+ T G LT A E LLQ
Sbjct: 536 S---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Score = 44.7 bits (104), Expect = 2e-05
Identities = 31/92 (33%), Positives = 44/92 (47%), Gaps = 4/92 (4%)
Query: 13 GDLDEVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
G EV D++ K G D+ G PL A+ G LE++++LL GA+++A T
Sbjct: 515 GGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTA 571
Query: 72 LLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
L A GH +LL GAD + G T
Sbjct: 572 LTYACENGHTDVADVLLQAGADLEHESEGGRT 603
Score = 43.9 bits (102), Expect = 3e-05
Identities = 29/95 (30%), Positives = 40/95 (42%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A G LD V+ + G D + L A G +E+ LL GA +N P
Sbjct: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 438
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+PL A GHV LL+ +GA+ +G T
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Score = 42.7 bits (99), Expect = 6e-05
Identities = 31/93 (33%), Positives = 44/93 (47%), Gaps = 1/93 (1%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D A G + V +A+ + + G PL AA G + ++E LL KG DI
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 63 AP-DKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
A ++ TPL A G V LLL++GA+K
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANK 1148
Score = 42.4 bits (98), Expect = 8e-05
Identities = 30/86 (34%), Positives = 39/86 (45%), Gaps = 2/86 (2%)
Query: 27 DVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAP--DKHHITPLLSAVYEGHVSCV 84
+V + G PL AA G E+ LL KGAD+NAP T L A +GH
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
Query: 85 KLLLSKGADKTVKGPDGLTAFEATDN 110
+LL+ +GA V+ G T N
Sbjct: 1309 ELLIHRGAHIDVRNKKGNTPLWLASN 1334
Score = 42.4 bits (98), Expect = 8e-05
Identities = 36/113 (31%), Positives = 50/113 (44%), Gaps = 13/113 (11%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKP--LHYAADCGQLEILEFLLLKGADINAP 64
M A G + + + KG DVN + L AAD G + E L+ +GA I+
Sbjct: 1262 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVR 1321
Query: 65 DKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
+K TPL A GH V+LL+ GAD +A DN+ I L+
Sbjct: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGAD-----------VDAADNRKITPLM 1363
Score = 41.6 bits (96), Expect = 1e-04
Identities = 26/82 (31%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Query: 13 GDLDEVKDYVAKGEDVNRTLEGGRK-PLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
G + V+ + KG D+ E + PL A G+ E+++ LL +GA+ + TP
Sbjct: 1099 GHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTP 1158
Query: 72 LLSAVYEGHVSCVKLLLSKGAD 93
L A G+V+ +K+LL+ GA+
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAE 1180
Score = 40.4 bits (93), Expect = 3e-04
Identities = 25/65 (38%), Positives = 37/65 (56%)
Query: 29 NRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLL 88
+R +G PL A+ G L+I++ LLL AD+N+ T L A G V VK+LL
Sbjct: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 89 SKGAD 93
++GA+
Sbjct: 326 NEGAN 330
Score = 39.3 bits (90), Expect = 7e-04
Identities = 29/83 (34%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNR-TLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD 65
M A + G L V+ ++KG +VNR T + A G L ++E LL GAD
Sbjct: 606 MKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRL 665
Query: 66 KHHITPLLSAVYEGHVSCVKLLL 88
K T L+ A GH + V LL
Sbjct: 666 KDGSTMLIEAAKGGHTNVVSYLL 688
Score = 38.9 bits (89), Expect = 9e-04
Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 3/98 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEG--GRKPLHYAADCGQLEILEFLLLKGADINAP-D 65
A G ++ +K + G ++N G PL AA G + ++ LL G+DINA +
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE 1221
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+ T L A ++G V LLL + A+ + GLT
Sbjct: 1222 TNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLT 1259
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 62.0 bits (149), Expect = 1e-10
Identities = 38/102 (37%), Positives = 56/102 (54%), Gaps = 1/102 (0%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D +A +NG D + G D+ EGGR PL AA G + ++FL+ KGA++N
Sbjct: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Query: 63 APDKHHITPLLS-AVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
++ +LS A GH++ V+LLL+ GAD T + DG T
Sbjct: 658 RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
Score = 60.5 bits (145), Expect = 3e-10
Identities = 34/92 (36%), Positives = 49/92 (53%)
Query: 2 CDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADI 61
C M A + G L+ VK +A G +V+ T G L YA + G ++ + LL GAD+
Sbjct: 564 CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623
Query: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSKGAD 93
+ TPL+ A GHV V+ L+SKGA+
Sbjct: 624 EHESEGGRTPLMKAARAGHVCTVQFLISKGAN 655
Score = 54.7 bits (130), Expect = 2e-08
Identities = 35/97 (36%), Positives = 48/97 (49%), Gaps = 1/97 (1%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD-KH 67
A GD++ V+ + +G VN E G L A G E+ + LL A++ K
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
ITPL++A GHV VKLLL+ AD + G TA
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337
Score = 52.8 bits (125), Expect = 6e-08
Identities = 24/69 (34%), Positives = 43/69 (62%)
Query: 22 VAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHV 81
+ +G ++ + G PL AA+ G L++++ L+ GAD++A D ITPL++A +GHV
Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHV 1399
Query: 82 SCVKLLLSK 90
V+ L+ +
Sbjct: 1400 KVVRYLVKE 1408
Score = 50.8 bits (120), Expect = 2e-07
Identities = 33/98 (33%), Positives = 47/98 (47%), Gaps = 1/98 (1%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINA-PDK 66
+A G +D VK + G + E G PL A G +E+ LL GA IN ++
Sbjct: 340 YACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
+ L A Y+GH+ V+ LL GAD+ K + TA
Sbjct: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTA 437
Score = 49.3 bits (116), Expect = 6e-07
Identities = 31/86 (36%), Positives = 43/86 (50%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A G + VK +A DVN G L YA G +++++ LL GA I ++
Sbjct: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGA 92
+ TPL+ A GHV +LLL GA
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGA 391
Score = 48.5 bits (114), Expect = 1e-06
Identities = 28/87 (32%), Positives = 43/87 (49%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A +G ++ + + G VN + PL AA G +E+ L+ +GA + +
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND 498
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGAD 93
TPL+ A EGH V LLL +GA+
Sbjct: 499 EGYTPLMEAAREGHEEMVALLLGQGAN 525
Score = 48.1 bits (113), Expect = 1e-06
Identities = 32/93 (34%), Positives = 46/93 (49%), Gaps = 2/93 (2%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D A G + V+ +A+G + PL AA G + I++ LL GA+IN
Sbjct: 1151 DTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1210
Query: 63 AP--DKHHITPLLSAVYEGHVSCVKLLLSKGAD 93
+ K I+PL+ A GH + VKLLL G+D
Sbjct: 1211 SRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSD 1243
Score = 47.0 bits (110), Expect = 3e-06
Identities = 40/117 (34%), Positives = 55/117 (47%), Gaps = 8/117 (6%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQ-LEILEFLLLKGADINAPD 65
M A + G + V + +G ++N E ++ A CG LE+ +FL+ GADI
Sbjct: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGAD---KTVKGPDGLT-AFEATDNQAIKALLQ 118
TPL+ A EGH+ VK LL+ GA+ T G LT A E LLQ
Sbjct: 565 S---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
Score = 45.8 bits (107), Expect = 7e-06
Identities = 30/88 (34%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKP-LHYAADCGQLEILEFLLLKGADINAPD 65
M A NG VK + G D+N +E R L A G+ E++ LL + A++
Sbjct: 1223 MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1282
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGAD 93
K +TPL+ A G+ ++LL KGAD
Sbjct: 1283 KTGLTPLMEAASGGYAEVGRVLLDKGAD 1310
Score = 44.7 bits (104), Expect = 2e-05
Identities = 31/93 (33%), Positives = 46/93 (49%), Gaps = 1/93 (1%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D A G + V+ + +G + + G PL AA G + ++E LL GADI
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143
Query: 63 AP-DKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
A ++ TPL A G V+LLL++GA+K
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANK 1176
Score = 43.9 bits (102), Expect = 3e-05
Identities = 32/92 (34%), Positives = 44/92 (47%), Gaps = 4/92 (4%)
Query: 13 GDLDEVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
G EV D++ K G D+ G PL AA G LE++++LL GA+++A T
Sbjct: 544 GGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Query: 72 LLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
L A GH +LL GAD + G T
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRT 632
Score = 43.5 bits (101), Expect = 4e-05
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKP--LHYAADCGQLEILEFLLLKGADINAP 64
M A G + + + KG DVN + L AAD G + E L+ +GA I+
Sbjct: 1290 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1349
Query: 65 DKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
+K TPL A GH+ V+LL+ GAD +A DN+ I L+
Sbjct: 1350 NKKGNTPLWLAANGGHLDVVQLLVQAGAD-----------VDAADNRKITPLM 1391
Score = 42.4 bits (98), Expect = 8e-05
Identities = 29/79 (36%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 27 DVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAP--DKHHITPLLSAVYEGHVSCV 84
+V + G PL AA G E+ LL KGAD+NAP T L A +GH
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
Query: 85 KLLLSKGADKTVKGPDGLT 103
+LL+ +GA V+ G T
Sbjct: 1337 ELLIGRGAHIDVRNKKGNT 1355
Score = 42.0 bits (97), Expect = 1e-04
Identities = 25/64 (39%), Positives = 36/64 (56%)
Query: 29 NRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLL 88
+R ++G PL AA+ G ++I++ LL AD+NA T L A G+V VK+LL
Sbjct: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
Query: 89 SKGA 92
GA
Sbjct: 355 ESGA 358
Score = 42.0 bits (97), Expect = 1e-04
Identities = 28/95 (29%), Positives = 39/95 (41%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A G L+ V+ + G D + L A G +E+ LL GA +N P
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+PL A GHV LL+ +GA +G T
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYT 502
Score = 41.2 bits (95), Expect = 2e-04
Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 15 LDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLS 74
LD D A+ E T PL A G+ E++E LL +GA+ + TPL
Sbjct: 1136 LDNGADIEAQSERTKDT------PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 1189
Query: 75 AVYEGHVSCVKLLLSKGAD 93
A G+V+ +K+LL+ GA+
Sbjct: 1190 AASGGYVNIIKILLNAGAE 1208
Score = 39.3 bits (90), Expect = 7e-04
Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGG-RKPLHYAADCGQLEILEFLLLKGADINAPD 65
M A + G + V+ ++KG +VNRT L A G L ++E LL GAD
Sbjct: 635 MKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRL 694
Query: 66 KHHITPLLSAVYEGHVSCVKLLL 88
K T L+ A GH S V LL
Sbjct: 695 KDGSTMLIEAAKGGHTSVVCYLL 717
Score = 38.1 bits (87), Expect = 0.001
Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 3/98 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEG--GRKPLHYAADCGQLEILEFLLLKGADINAP-D 65
A G ++ +K + G ++N G PL AA G ++ LL G+DINA +
Sbjct: 1190 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 1249
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+ T L A ++G V LLL + A+ + GLT
Sbjct: 1250 TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLT 1287
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 62.0 bits (149), Expect = 1e-10
Identities = 38/102 (37%), Positives = 56/102 (54%), Gaps = 1/102 (0%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D +A +NG D + G D+ EGGR PL AA G + ++FL+ KGA++N
Sbjct: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Query: 63 APDKHHITPLLS-AVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
++ +LS A GH++ V+LLL+ GAD T + DG T
Sbjct: 658 RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
Score = 60.5 bits (145), Expect = 3e-10
Identities = 34/92 (36%), Positives = 49/92 (53%)
Query: 2 CDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADI 61
C M A + G L+ VK +A G +V+ T G L YA + G ++ + LL GAD+
Sbjct: 564 CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623
Query: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSKGAD 93
+ TPL+ A GHV V+ L+SKGA+
Sbjct: 624 EHESEGGRTPLMKAARAGHVCTVQFLISKGAN 655
Score = 54.7 bits (130), Expect = 2e-08
Identities = 35/97 (36%), Positives = 48/97 (49%), Gaps = 1/97 (1%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD-KH 67
A GD++ V+ + +G VN E G L A G E+ + LL A++ K
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
ITPL++A GHV VKLLL+ AD + G TA
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337
Score = 52.8 bits (125), Expect = 6e-08
Identities = 24/69 (34%), Positives = 43/69 (62%)
Query: 22 VAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHV 81
+ +G ++ + G PL AA+ G L++++ L+ GAD++A D ITPL++A +GHV
Sbjct: 1089 IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHV 1148
Query: 82 SCVKLLLSK 90
V+ L+ +
Sbjct: 1149 KVVRYLVKE 1157
Score = 50.8 bits (120), Expect = 2e-07
Identities = 33/98 (33%), Positives = 47/98 (47%), Gaps = 1/98 (1%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINA-PDK 66
+A G +D VK + G + E G PL A G +E+ LL GA IN ++
Sbjct: 340 YACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
+ L A Y+GH+ V+ LL GAD+ K + TA
Sbjct: 400 FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTA 437
Score = 49.3 bits (116), Expect = 6e-07
Identities = 31/86 (36%), Positives = 43/86 (50%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A G + VK +A DVN G L YA G +++++ LL GA I ++
Sbjct: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGA 92
+ TPL+ A GHV +LLL GA
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGA 391
Score = 48.5 bits (114), Expect = 1e-06
Identities = 28/87 (32%), Positives = 43/87 (49%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A +G ++ + + G VN + PL AA G +E+ L+ +GA + +
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND 498
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGAD 93
TPL+ A EGH V LLL +GA+
Sbjct: 499 EGYTPLMEAAREGHEEMVALLLGQGAN 525
Score = 48.1 bits (113), Expect = 1e-06
Identities = 32/93 (34%), Positives = 46/93 (49%), Gaps = 2/93 (2%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D A G + V+ +A+G + PL AA G + I++ LL GA+IN
Sbjct: 900 DTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 959
Query: 63 AP--DKHHITPLLSAVYEGHVSCVKLLLSKGAD 93
+ K I+PL+ A GH + VKLLL G+D
Sbjct: 960 SRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSD 992
Score = 47.0 bits (110), Expect = 3e-06
Identities = 40/117 (34%), Positives = 55/117 (47%), Gaps = 8/117 (6%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQ-LEILEFLLLKGADINAPD 65
M A + G + V + +G ++N E ++ A CG LE+ +FL+ GADI
Sbjct: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGAD---KTVKGPDGLT-AFEATDNQAIKALLQ 118
TPL+ A EGH+ VK LL+ GA+ T G LT A E LLQ
Sbjct: 565 S---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
Score = 45.8 bits (107), Expect = 7e-06
Identities = 30/88 (34%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKP-LHYAADCGQLEILEFLLLKGADINAPD 65
M A NG VK + G D+N +E R L A G+ E++ LL + A++
Sbjct: 972 MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGAD 93
K +TPL+ A G+ ++LL KGAD
Sbjct: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGAD 1059
Score = 44.7 bits (104), Expect = 2e-05
Identities = 31/93 (33%), Positives = 46/93 (49%), Gaps = 1/93 (1%)
Query: 3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN 62
D A G + V+ + +G + + G PL AA G + ++E LL GADI
Sbjct: 833 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 892
Query: 63 AP-DKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
A ++ TPL A G V+LLL++GA+K
Sbjct: 893 AQSERTKDTPLSLACSGGRQEVVELLLARGANK 925
Score = 43.9 bits (102), Expect = 3e-05
Identities = 32/92 (34%), Positives = 44/92 (47%), Gaps = 4/92 (4%)
Query: 13 GDLDEVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
G EV D++ K G D+ G PL AA G LE++++LL GA+++A T
Sbjct: 544 GGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Query: 72 LLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
L A GH +LL GAD + G T
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRT 632
Score = 43.5 bits (101), Expect = 4e-05
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKP--LHYAADCGQLEILEFLLLKGADINAP 64
M A G + + + KG DVN + L AAD G + E L+ +GA I+
Sbjct: 1039 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1098
Query: 65 DKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
+K TPL A GH+ V+LL+ GAD +A DN+ I L+
Sbjct: 1099 NKKGNTPLWLAANGGHLDVVQLLVQAGAD-----------VDAADNRKITPLM 1140
Score = 42.4 bits (98), Expect = 8e-05
Identities = 29/79 (36%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 27 DVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAP--DKHHITPLLSAVYEGHVSCV 84
+V + G PL AA G E+ LL KGAD+NAP T L A +GH
Sbjct: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
Query: 85 KLLLSKGADKTVKGPDGLT 103
+LL+ +GA V+ G T
Sbjct: 1086 ELLIGRGAHIDVRNKKGNT 1104
Score = 42.0 bits (97), Expect = 1e-04
Identities = 25/64 (39%), Positives = 36/64 (56%)
Query: 29 NRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLL 88
+R ++G PL AA+ G ++I++ LL AD+NA T L A G+V VK+LL
Sbjct: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
Query: 89 SKGA 92
GA
Sbjct: 355 ESGA 358
Score = 42.0 bits (97), Expect = 1e-04
Identities = 28/95 (29%), Positives = 39/95 (41%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A G L+ V+ + G D + L A G +E+ LL GA +N P
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+PL A GHV LL+ +GA +G T
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYT 502
Score = 41.2 bits (95), Expect = 2e-04
Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 15 LDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLS 74
LD D A+ E T PL A G+ E++E LL +GA+ + TPL
Sbjct: 885 LDNGADIEAQSERTKDT------PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
Query: 75 AVYEGHVSCVKLLLSKGAD 93
A G+V+ +K+LL+ GA+
Sbjct: 939 AASGGYVNIIKILLNAGAE 957
Score = 39.3 bits (90), Expect = 7e-04
Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGG-RKPLHYAADCGQLEILEFLLLKGADINAPD 65
M A + G + V+ ++KG +VNRT L A G L ++E LL GAD
Sbjct: 635 MKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRL 694
Query: 66 KHHITPLLSAVYEGHVSCVKLLL 88
K T L+ A GH S V LL
Sbjct: 695 KDGSTMLIEAAKGGHTSVVCYLL 717
Score = 38.1 bits (87), Expect = 0.001
Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 3/98 (3%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEG--GRKPLHYAADCGQLEILEFLLLKGADINAP-D 65
A G ++ +K + G ++N G PL AA G ++ LL G+DINA +
Sbjct: 939 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 998
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+ T L A ++G V LLL + A+ + GLT
Sbjct: 999 TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLT 1036
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 61.6 bits (148), Expect = 1e-10
Identities = 36/80 (45%), Positives = 46/80 (57%)
Query: 28 VNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLL 87
VN + GGR LH+AA G +E++ LL KGA+INA DK L A Y GH+ V LL
Sbjct: 108 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Query: 88 LSKGADKTVKGPDGLTAFEA 107
++ GA+ T K G T A
Sbjct: 168 INHGAEVTCKDKKGYTPLHA 187
Score = 57.8 bits (138), Expect = 2e-09
Identities = 36/94 (38%), Positives = 48/94 (51%), Gaps = 1/94 (1%)
Query: 22 VAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHV 81
+ K EDVN R PLH AA G EI+E L+L GA +NA D +TPL AV
Sbjct: 3 IHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSE 62
Query: 82 SCVKLLLSKGADKTVKGPDGLTAFE-ATDNQAIK 114
V++L+ AD + + T A N+A+K
Sbjct: 63 EAVQVLIKHSADVNARDKNWQTPLHVAAANKAVK 96
Score = 57.0 bits (136), Expect = 3e-09
Identities = 30/85 (35%), Positives = 49/85 (57%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A NG ++ V +AKG ++N + R+ LH+AA G L+++ L+ GA++ DK
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGAD 93
TPL +A G ++ VK LL+ G +
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVE 206
Score = 52.4 bits (124), Expect = 8e-08
Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 1/101 (0%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A NG ++ VK + G +++ G LH A GQ ++ L+ GA++N P+ +
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247
Query: 69 ITPLLSAVYEGH-VSCVKLLLSKGADKTVKGPDGLTAFEAT 108
TPL A H C++LL++ GAD ++ DG + T
Sbjct: 248 FTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288
Score = 47.0 bits (110), Expect = 3e-06
Identities = 31/96 (32%), Positives = 46/96 (47%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67
WA G LD V + G +V + G PLH AA GQ+ +++ LL G +I+ + +
Sbjct: 154 WAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVY 213
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
T L A Y G + V L+ GA+ +G T
Sbjct: 214 GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249
Score = 46.2 bits (108), Expect = 5e-06
Identities = 34/112 (30%), Positives = 52/112 (46%), Gaps = 3/112 (2%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A N D + ++ G +++ + GR LH AA G +E ++ L GAD + DK
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFE---ATDNQAIKALL 117
TPL A H C++ L++ GA+ G TA A+D K +L
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL 465
Score = 44.7 bits (104), Expect = 2e-05
Identities = 33/116 (28%), Positives = 54/116 (46%), Gaps = 14/116 (12%)
Query: 4 KEFMW------ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLK 57
K+ MW A+ + + V+ + DVN + + PLH AA ++ E ++
Sbjct: 45 KDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPL 104
Query: 58 GADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAI 113
+ +N D+ T L A GHV V LLL+KGA+ + AF+ D +A+
Sbjct: 105 LSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGAN--------INAFDKKDRRAL 152
Score = 44.3 bits (103), Expect = 2e-05
Identities = 26/72 (36%), Positives = 35/72 (48%)
Query: 22 VAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHV 81
V G DVN + G+ PLH A G+ + L+ G +I+ DK TPL A GH
Sbjct: 268 VNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHE 327
Query: 82 SCVKLLLSKGAD 93
+ L + GAD
Sbjct: 328 LLINTLRTSGAD 339
Score = 44.3 bits (103), Expect = 2e-05
Identities = 28/66 (42%), Positives = 34/66 (51%)
Query: 38 PLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVK 97
PLH AA + LL G +I+ PDK T L +A G+V C+KLL S GAD K
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 98 GPDGLT 103
G T
Sbjct: 410 DKCGRT 415
Score = 43.1 bits (100), Expect = 5e-05
Identities = 24/62 (38%), Positives = 34/62 (54%)
Query: 36 RKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKT 95
+ PLH AA G + LE LL D++ D+ T L A ++GH CV+ L++ GA
Sbjct: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIF 602
Query: 96 VK 97
VK
Sbjct: 603 VK 604
Score = 41.2 bits (95), Expect = 2e-04
Identities = 27/67 (40%), Positives = 33/67 (49%), Gaps = 1/67 (1%)
Query: 35 GRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLL-SKGAD 93
GR PL AA +E L+ LL A +NA D T L+ A G V +L+ S AD
Sbjct: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQAD 873
Query: 94 KTVKGPD 100
TVK D
Sbjct: 874 LTVKDKD 880
Score = 40.8 bits (94), Expect = 2e-04
Identities = 29/96 (30%), Positives = 42/96 (43%), Gaps = 1/96 (1%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEI-LEFLLLKGADINAPDKH 67
A NG V + + G +VN+ G PLH+AA + LE L+ GAD+N K
Sbjct: 221 ACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD 280
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+PL G + + L+ G + DG T
Sbjct: 281 GKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNT 316
Score = 39.7 bits (91), Expect = 5e-04
Identities = 26/96 (27%), Positives = 38/96 (39%)
Query: 12 NGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITP 71
+G + + G +++ + G PLH AA G ++ L GAD H + P
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
Query: 72 LLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEA 107
L A H C + LLS G + G T A
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHA 386
Score = 38.1 bits (87), Expect = 0.001
Identities = 24/59 (40%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 35 GRKPLHYAADCGQLEILEFLL---LKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSK 90
GR PLHYAA G L LL L D D TPL A Y G+ +C+++LL +
Sbjct: 711 GRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769
Score = 37.7 bits (86), Expect = 0.002
Identities = 41/146 (28%), Positives = 61/146 (41%), Gaps = 36/146 (24%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAA----------------DCGQLE-- 49
+A N ++ V G +VN T + GR LHYAA + +LE
Sbjct: 419 YAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERA 478
Query: 50 ----------ILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSK---GADKT- 95
LEFLL A+ + DK + A GH C++LLL + G +++
Sbjct: 479 RELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESD 538
Query: 96 ---VKGPDGLTAFEATDNQAIKALLQ 118
K P L A+ +QA++ LLQ
Sbjct: 539 SGATKSPLHLAAYNG-HHQALEVLLQ 563
Score = 37.4 bits (85), Expect = 0.003
Identities = 24/70 (34%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
Query: 28 VNRTLEGGRKPLHYAADCGQLEILEFLLLKG-ADINAPDKHHITPLLSAVYEGHVSCVKL 86
VN G+ L AA+ GQ ++ L+ AD+ DK TPL A +GH C L
Sbjct: 840 VNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALL 899
Query: 87 LLSKGADKTV 96
+L K D+++
Sbjct: 900 ILDKIQDESL 909
Score = 35.8 bits (81), Expect = 0.007
Identities = 21/69 (30%), Positives = 32/69 (46%)
Query: 35 GRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADK 94
G+ PL A G ++ + LL K A+++ D T L + GH CV++LL +
Sbjct: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSI 704
Query: 95 TVKGPDGLT 103
K G T
Sbjct: 705 LCKDSRGRT 713
Score = 34.3 bits (77), Expect = 0.022
Identities = 28/73 (38%), Positives = 35/73 (47%), Gaps = 5/73 (6%)
Query: 36 RKPLHYAADCGQLEILEFLLLKGAD----INAPDKHHITPLLSAVYEGHVSCVKLLLSKG 91
R PLH + G L LLL+ AD ++ D TPL+ AV GH+ V LLL K
Sbjct: 610 RTPLHASVINGHTLCLR-LLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
Query: 92 ADKTVKGPDGLTA 104
A+ G TA
Sbjct: 669 ANVDTVDILGCTA 681
Score = 33.9 bits (76), Expect = 0.028
Identities = 23/74 (31%), Positives = 34/74 (45%), Gaps = 2/74 (2%)
Query: 35 GRKPLHYAADCGQLEILEFLLLK-GADINAPDKHHI-TPLLSAVYEGHVSCVKLLLSKGA 92
G +HYAA G + LE LL + + D +PL A Y GH +++LL
Sbjct: 507 GYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLV 566
Query: 93 DKTVKGPDGLTAFE 106
D ++ G TA +
Sbjct: 567 DLDIRDEKGRTALD 580
Score = 32.3 bits (72), Expect = 0.082
Identities = 26/99 (26%), Positives = 42/99 (42%), Gaps = 3/99 (3%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAA--DCGQLEILEFLLLKGADINAPD 65
WA NG+ + + + + + + + PLH A D G L + + ++ D
Sbjct: 753 WACYNGN-ENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRD 811
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA 104
TPL +A + HV C++LLL A G TA
Sbjct: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTA 850
Score = 30.0 bits (66), Expect = 0.41
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 4/69 (5%)
Query: 54 LLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT----AFEATD 109
L+ K D+N D TPL A + G ++LL+ GA K LT A +
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 110 NQAIKALLQ 118
+A++ L++
Sbjct: 62 EEAVQVLIK 70
Score = 29.6 bits (65), Expect = 0.53
Identities = 24/82 (29%), Positives = 34/82 (41%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A+ G +D V + K +V+ G LH G E ++ LL + I D
Sbjct: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS 709
Query: 67 HHITPLLSAVYEGHVSCVKLLL 88
TPL A GH + + LL
Sbjct: 710 RGRTPLHYAAARGHATWLSELL 731
>gi|34304383 Usher syndrome 1G protein [Homo sapiens]
Length = 461
Score = 60.8 bits (146), Expect = 2e-10
Identities = 34/93 (36%), Positives = 52/93 (55%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
+WA +G+L+ ++ V++G D ++ G PLH AA G L L FL+ GA+I D
Sbjct: 37 LWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDN 96
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGP 99
+ TPL A +GH+ CV+ L S A ++ P
Sbjct: 97 DYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNP 129
Score = 44.3 bits (103), Expect = 2e-05
Identities = 29/85 (34%), Positives = 45/85 (52%), Gaps = 2/85 (2%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A ++G L+ +K+ K ++N E G P +AA G LE L ++ +G D + D
Sbjct: 8 AARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
Query: 69 ITPLLSAVYEGHVSCVKLLLSKGAD 93
TPL A GH+ C+ L+S GA+
Sbjct: 66 NTPLHLAASNGHLHCLSFLVSFGAN 90
>gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
Length = 871
Score = 60.5 bits (145), Expect = 3e-10
Identities = 38/100 (38%), Positives = 56/100 (56%), Gaps = 2/100 (2%)
Query: 9 ALKNGDLDEVKDYVAKGED-VNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK- 66
ALK G+ VK+ + VN G PL AA GQL +++ L+ + AD++ D
Sbjct: 299 ALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSV 358
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFE 106
H T L+ A Y G+ VK LL++GAD T++ +G TAF+
Sbjct: 359 HGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFD 398
Score = 45.1 bits (105), Expect = 1e-05
Identities = 24/61 (39%), Positives = 34/61 (55%)
Query: 33 EGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGA 92
E G L +AA G ++ FLL +GA +N+ + + + L+ A GHVS LLL GA
Sbjct: 76 EAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGA 135
Query: 93 D 93
D
Sbjct: 136 D 136
Score = 42.7 bits (99), Expect = 6e-05
Identities = 31/94 (32%), Positives = 42/94 (44%)
Query: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67
+A G V+ + +G VN G L AA G + + LL GAD+NA ++
Sbjct: 84 FAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRL 143
Query: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDG 101
+ L A GH+ VKLLL GA P G
Sbjct: 144 GASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG 177
Score = 37.4 bits (85), Expect = 0.003
Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 20/104 (19%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
M A + G + + G DVN G L A+ G L +++ LL GA + D
Sbjct: 116 MQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFV---DH 172
Query: 67 HH-----------------ITPLLSAVYEGHVSCVKLLLSKGAD 93
HH IT L++A+ GH + V+LL+ GAD
Sbjct: 173 HHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGAD 216
Score = 26.6 bits (57), Expect = 4.5
Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 6/78 (7%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEG-GRKPLHYAADCGQLEILEFLLLKGADINAPD 65
M A+++G V+ + G D N G PL AA G+L + + L+ KGA+ PD
Sbjct: 196 MAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN---PD 252
Query: 66 KHHITPLLSAVYEGHVSC 83
H++ L +E + C
Sbjct: 253 --HLSVLEKTAFEVALDC 268
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 59.7 bits (143), Expect = 5e-10
Identities = 39/113 (34%), Positives = 60/113 (53%), Gaps = 1/113 (0%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66
+WA + +D VK ++KG D+N LH+AA G ++I E LL D++A +
Sbjct: 878 IWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNI 937
Query: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFE-ATDNQAIKALLQ 118
H +PL A E CV L LS+ +D T+K +G T + A+ N + + LQ
Sbjct: 938 HGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQ 990
Score = 55.8 bits (133), Expect = 7e-09
Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 4 KEFMWALKNGDLDEVKDYVAKGEDVNRTLE--GGRKPLHYAADCGQLEILEFLLLKGADI 61
K+ ++ + G+L +V + G D N +E R PLH AA+ G ++I L+ GA+I
Sbjct: 740 KQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
Query: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
+ + TPL+ A H+ VK L+ GA K +G T
Sbjct: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGST 841
Score = 55.1 bits (131), Expect = 1e-08
Identities = 35/92 (38%), Positives = 49/92 (53%), Gaps = 1/92 (1%)
Query: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGA-DINAPD 65
M A +N L+ VK + G V+ G LH AA G E++++LL G D+N D
Sbjct: 811 MEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQD 870
Query: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVK 97
TP++ A HV VKLLLSKG+D ++
Sbjct: 871 DGGWTPMIWATEYKHVDLVKLLLSKGSDINIR 902
Score = 41.6 bits (96), Expect = 1e-04
Identities = 27/83 (32%), Positives = 41/83 (49%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A + G +D V G +++ E R PL AA+ LE +++L+ GA ++ D
Sbjct: 780 AAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEG 839
Query: 69 ITPLLSAVYEGHVSCVKLLLSKG 91
T L A +GH V+ LLS G
Sbjct: 840 STCLHLAAKKGHYEVVQYLLSNG 862
>gi|4506499 regulatory factor X-associated ankyrin-containing
protein isoform a [Homo sapiens]
Length = 260
Score = 59.3 bits (142), Expect = 6e-10
Identities = 42/128 (32%), Positives = 62/128 (48%), Gaps = 34/128 (26%)
Query: 13 GDLDEVKDYVAKGED-VNRTLEGGRKPLHYAADCGQLEILEFLLLKGA------------ 59
G+LD++K+++ KG++ VN+ E G PL +A+ G++E + FLL GA
Sbjct: 101 GELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESA 160
Query: 60 ---------------------DINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKG 98
DIN D + TPLL AV HV CV+ LL++GAD T +
Sbjct: 161 LSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA 220
Query: 99 PDGLTAFE 106
G T +
Sbjct: 221 DSGYTPMD 228
Score = 29.6 bits (65), Expect = 0.53
Identities = 22/72 (30%), Positives = 32/72 (44%)
Query: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68
A G D V + + D+N G PL YA ++ +E LL +GAD+
Sbjct: 164 ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 223
Query: 69 ITPLLSAVYEGH 80
TP+ AV G+
Sbjct: 224 YTPMDLAVALGY 235
>gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo
sapiens]
Length = 282
Score = 58.9 bits (141), Expect = 8e-10
Identities = 41/117 (35%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 3 DKEFMWALKNGDLDEV-KDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADI 61
DK + ++D + K +K DVN E GR LH+A D G E++ LL ADI
Sbjct: 159 DKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADI 218
Query: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ 118
N D T L A + V+LLL GAD T++ DG E T + + +LQ
Sbjct: 219 NCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVLQ 275
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.137 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,527,705
Number of Sequences: 37866
Number of extensions: 180176
Number of successful extensions: 2348
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 347
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 392
Number of HSP's gapped (non-prelim): 1657
length of query: 118
length of database: 18,247,518
effective HSP length: 88
effective length of query: 30
effective length of database: 14,915,310
effective search space: 447459300
effective search space used: 447459300
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 55 (25.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.