Search of human proteins with 219555661

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|219555661 intraflagellar transport 81-like isoform 1 [Homo
sapiens]
         (676 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|219555661 intraflagellar transport 81-like isoform 1 [Homo sa...  1308   0.0  
gi|32526901 intraflagellar transport 81-like isoform 1 [Homo sap...  1308   0.0  
gi|34147403 intraflagellar transport 81-like isoform 2 [Homo sap...   764   0.0  
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                  103   4e-22
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    91   3e-18
gi|71061468 centromere protein E [Homo sapiens]                        90   6e-18
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         89   1e-17
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              89   2e-17
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    88   2e-17
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    88   2e-17
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    87   5e-17
gi|148746195 trichohyalin [Homo sapiens]                               87   7e-17
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    86   1e-16
gi|237858621 polyamine modulated factor 1 binding protein 1 isof...    83   7e-16
gi|237858619 polyamine modulated factor 1 binding protein 1 isof...    83   7e-16
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             83   9e-16
gi|109255234 centrosomal protein 290kDa [Homo sapiens]                 82   1e-15
gi|34577114 cytomatrix protein p110 [Homo sapiens]                     82   2e-15
gi|58530840 desmoplakin isoform I [Homo sapiens]                       82   2e-15
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    81   3e-15
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    81   3e-15
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    81   4e-15
gi|41872583 Rho-associated, coiled-coil containing protein kinas...    81   4e-15
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    81   4e-15
gi|221219020 NYD-SP11 protein [Homo sapiens]                           80   6e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     80   8e-15
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    80   8e-15
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    80   8e-15
gi|38044112 restin isoform b [Homo sapiens]                            79   1e-14
gi|4506751 restin isoform a [Homo sapiens]                             79   1e-14

>gi|219555661 intraflagellar transport 81-like isoform 1 [Homo
           sapiens]
          Length = 676

 Score = 1308 bits (3384), Expect = 0.0
 Identities = 676/676 (100%), Positives = 676/676 (100%)

Query: 1   MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60
           MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ
Sbjct: 1   MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60

Query: 61  TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120
           TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR
Sbjct: 61  TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120

Query: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
           FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180

Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
           EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL
Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240

Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
           QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS
Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300

Query: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
           EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE
Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360

Query: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE 420
           ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE
Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE 420

Query: 421 LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG 480
           LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG
Sbjct: 421 LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG 480

Query: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540
           RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE
Sbjct: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540

Query: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600
           SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI
Sbjct: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600

Query: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT 660
           REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT
Sbjct: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT 660

Query: 661 SIGQVIQEGGEDRLIL 676
           SIGQVIQEGGEDRLIL
Sbjct: 661 SIGQVIQEGGEDRLIL 676


>gi|32526901 intraflagellar transport 81-like isoform 1 [Homo
           sapiens]
          Length = 676

 Score = 1308 bits (3384), Expect = 0.0
 Identities = 676/676 (100%), Positives = 676/676 (100%)

Query: 1   MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60
           MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ
Sbjct: 1   MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60

Query: 61  TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120
           TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR
Sbjct: 61  TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120

Query: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
           FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180

Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
           EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL
Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240

Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
           QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS
Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300

Query: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
           EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE
Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360

Query: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE 420
           ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE
Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE 420

Query: 421 LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG 480
           LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG
Sbjct: 421 LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG 480

Query: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540
           RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE
Sbjct: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540

Query: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600
           SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI
Sbjct: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600

Query: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT 660
           REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT
Sbjct: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT 660

Query: 661 SIGQVIQEGGEDRLIL 676
           SIGQVIQEGGEDRLIL
Sbjct: 661 SIGQVIQEGGEDRLIL 676


>gi|34147403 intraflagellar transport 81-like isoform 2 [Homo
           sapiens]
          Length = 431

 Score =  764 bits (1974), Expect = 0.0
 Identities = 396/396 (100%), Positives = 396/396 (100%)

Query: 1   MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60
           MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ
Sbjct: 1   MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60

Query: 61  TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120
           TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR
Sbjct: 61  TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120

Query: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
           FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180

Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
           EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL
Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240

Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
           QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS
Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300

Query: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
           EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE
Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360

Query: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE 396
           ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE
Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE 396



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 48/224 (21%), Positives = 101/224 (45%), Gaps = 38/224 (16%)

Query: 407 KSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTME---EKKGISGYSYTQE 463
           K   +  +  I  E+ +EF L   T     +++E + +  +T+    E+  ISG+S T E
Sbjct: 113 KKRAYLARFLIKLEVPSEF-LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFS-TAE 170

Query: 464 ELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQ 523
             + +SA++ E D++  R      E +KK     ++    +  + ++LR  +++ + L Q
Sbjct: 171 IRKDISAMEEEKDQLIKRV-----EHLKKRVE-TAQNHQWMLKIARQLRVEKEREEYLAQ 224

Query: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATD 583
           +  E+K+Q       L+    +++ +++ +R+     +             E  ++R  +
Sbjct: 225 QKQEQKNQLFHAVQRLQ----RVQNQLKSMRQAAADAKP------------ESLMKRLEE 268

Query: 584 EMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRE 627
           E+K  +          + E++ K   E EN  K+L   QKV+ E
Sbjct: 269 EIKFNL--------YMVTEKFPK---ELENKKKELHFLQKVVSE 301


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score =  103 bits (258), Expect = 4e-22
 Identities = 120/559 (21%), Positives = 258/559 (46%), Gaps = 64/559 (11%)

Query: 141  NKQYEELMEAFKTLHKEY-EQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETA 199
            N ++E++  AF+   K + EQ K       E+ K I  +E    QL K+ +  K++ +T 
Sbjct: 742  NTEHEKICLAFEKAKKIHLEQHK-------EMEKQIERLEA---QLEKKDQQFKEQEKTM 791

Query: 200  QNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKP 259
               Q  + I +Q  +E   +  L + K E K +     + L+ +QNQ+    +     + 
Sbjct: 792  SMLQQDI-ICKQHHLES-LDRLLTESKGEMKKENMKKDEALKALQNQVSE--ETIKVRQL 847

Query: 260  ESLMKRLEEEIKFNLYMVT---EKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKI 316
            +S ++  +EE+  +L  +    EKF K+L+ K +E++ LQK +        +  E    +
Sbjct: 848  DSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVIL 907

Query: 317  NEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIIS----RKKEAKAEELQEAKEKLASL 372
                 +  Q+++++ +RN  +E   +   +Q S +     +++E+ AE+L++ +EK  S 
Sbjct: 908  QHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESA 967

Query: 373  EREASVKRNQTREFDGTE---VLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQ 429
              EA +KR +  E  GT     ++ D++K  ++K+  +    K+      E KA    L 
Sbjct: 968  AHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD----GENKAMH--LS 1021

Query: 430  RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQ--EELERVSALKSEVDEMKG------R 481
            + + +L Q    ++++   ++E + +   + T+  E L++   L++E+    G      R
Sbjct: 1022 QLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLR 1081

Query: 482  TLDDMSEMVKKLYSLVSEKKSALASVIKELR----QLRQKYQELTQ----------ECDE 527
             L ++ ++++K    + EK + +  +  ELR    ++  K QEL +          E  +
Sbjct: 1082 QLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQ 1141

Query: 528  KKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEM-- 585
            + +Q       +  +R ++EQ++ +L     + E      N  I++L  +L+ A +++  
Sbjct: 1142 RAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLRE 1201

Query: 586  KAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645
            K +I    +++   +++       E E   ++++E + V++E       Q K   DL Q 
Sbjct: 1202 KEFIMLQNEQEISQLKK-------EIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQE 1254

Query: 646  MECKKQCFLKQQSQTSIGQ 664
            +   ++    Q S T + +
Sbjct: 1255 LRLTRE--QVQNSHTELAE 1271



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 146/703 (20%), Positives = 277/703 (39%), Gaps = 134/703 (19%)

Query: 35  LQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLL----GILKYKP-------SGNATDM 83
           LQ L + L+ + P +  D     P ++ K +L +     G+L Y P       SG++TD 
Sbjct: 154 LQSLGEELSSVSPSENSDYAPN-PSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDF 212

Query: 84  STFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQ 143
               +  +  S   +   +  L ++ N+L+++                      A    Q
Sbjct: 213 QKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQN---------------------ACLVTQ 251

Query: 144 YEELMEAFKTLHKEYEQ--LKISGFSTAE--------IRKDISAMEEE---KDQLIKRVE 190
              LM  F+++H E  Q   K+S   +A+        + + I  +E E   +D++++  E
Sbjct: 252 NHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAE 311

Query: 191 H-----LKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN 245
           +      K  +E  Q+ Q   +   +L+V+   +    ++ + Q+N+  +  + L +   
Sbjct: 312 NKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQ 371

Query: 246 QLKSMRQAAADAKPESLMK-RLEEEIKFNLYMVTEKFPKELENK----KKELHF----LQ 296
           Q K           E L K + EEEI        EK  K L+ +    K EL      L+
Sbjct: 372 QYKK-------KVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLR 424

Query: 297 KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKE 356
           ++  E   G   L  +  K +E+  ++ +  +  +     +E K  + R + S+++  +E
Sbjct: 425 QLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRE 484

Query: 357 AKA-------------EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK 403
            K              +E++ ++ +L SLE+  S    +   F     L   +   + NK
Sbjct: 485 LKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNK 544

Query: 404 LRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHEN-----IQQQLQTMEEKKGISGY 458
                   +    +I+EL+ +  +    E  +++ H N     + Q L T  +       
Sbjct: 545 EDRCIGCCEANKLVISELRIKLAI---KEAEIQKLHANLTANQLSQSLITCND------- 594

Query: 459 SYTQEELERVSALKSEVDEMKGRTL-----DDMSEMVKKLYSLVSEKKSALASVIKELR- 512
               +E  ++S+L++E  ++ G  +     D     + K Y    +++  L + I+ELR 
Sbjct: 595 ---SQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY---EKERQRLVTGIEELRT 648

Query: 513 ---QLRQKYQELTQECDEKKSQYDSCAAGL---ESNRSKLEQEVRRLREECLQ-----EE 561
              Q+  +  +L      + SQ+      L    SN SKLE E+ +   + L      EE
Sbjct: 649 KLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEE 708

Query: 562 SRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREK 621
               Y++   KN E++              +  EK + IR   T    E E +     + 
Sbjct: 709 KIVAYSSIAAKNAELE-------------QELMEKNEKIRSLETNINTEHEKICLAFEKA 755

Query: 622 QKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQ 664
           +K+  E H    KQ +    LE  +E K Q F +Q+   S+ Q
Sbjct: 756 KKIHLEQHKEMEKQIER---LEAQLEKKDQQFKEQEKTMSMLQ 795



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 106/541 (19%), Positives = 236/541 (43%), Gaps = 49/541 (9%)

Query: 133  QDETVADTNKQYEELMEAFKTLHKEYEQLKIS----GFSTAEIRKDISAMEEEKDQLIKR 188
            Q+E +    ++ E      ++L K   QL +     GF +   +  +S+   ++D+ I  
Sbjct: 492  QNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGC 551

Query: 189  VEHLKK-----RVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL--- 240
             E  K      R++ A     + K+   L   +  +  +     ++ ++L          
Sbjct: 552  CEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKL 611

Query: 241  --QRVQNQLKSMRQAAADAKPESLMKRLE---EEIKFNLYMVTEKFPKELENKKKELHFL 295
               +V   +K   Q   + + E   +RL    EE++  L  +      E EN   +++  
Sbjct: 612  GGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQI------EAENSDLKVNMA 665

Query: 296  QKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355
             +  S+  +   +LLE  S  +++ +E+ +   + +   + +E K+  Y    S I+ K 
Sbjct: 666  HRT-SQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAY----SSIAAKN 720

Query: 356  EAKAEELQEAKEKLASLEREASVKRNQ-TREFDGTEVLKGDEFKRYVNKLRSKSTVFKKK 414
                +EL E  EK+ SLE   + +  +    F+  + +  ++ K    ++       +KK
Sbjct: 721  AELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKK 780

Query: 415  HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474
             Q   E +    +LQ+ + + KQ H     +L T  E KG       +++ E + AL+++
Sbjct: 781  DQQFKEQEKTMSMLQQ-DIICKQHHLESLDRLLT--ESKGEMKKENMKKD-EALKALQNQ 836

Query: 475  VDE--MKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQY 532
            V E  +K R LD   E+ K+   LV        +  K  +QL++K +E+   C +K+ + 
Sbjct: 837  VSEETIKVRQLDSALEICKE--ELVLHLNQLEGNKEKFEKQLKKKSEEV--YCLQKELKI 892

Query: 533  DSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSD 592
             + +    S ++ + Q   + +++ LQ+E+     N  +++ + +L +   +++  +   
Sbjct: 893  KNHSLQETSEQNVILQHTLQQQQQMLQQET---IRNGELEDTQTKLEKQVSKLEQELQKQ 949

Query: 593  QQEKRKAIR--EQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKK 650
            ++   + +R  E+  ++ A + +L     ++QKVI  +      + +M +  E+L + +K
Sbjct: 950  RESSAEKLRKMEEKCESAAHEADL-----KRQKVIELTGTARQVKIEMDQYKEELSKMEK 1004

Query: 651  Q 651
            +
Sbjct: 1005 E 1005



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 100/524 (19%), Positives = 223/524 (42%), Gaps = 92/524 (17%)

Query: 133  QDETVADTNKQYEELME--AFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVE 190
            Q E+ A+  ++ EE  E  A +   K  + ++++G +  +++ ++   +EE  ++ K + 
Sbjct: 949  QRESSAEKLRKMEEKCESAAHEADLKRQKVIELTG-TARQVKIEMDQYKEELSKMEKEIM 1007

Query: 191  HLKKRVETAQNHQWMLK-IARQLRVEKERE----EYLAQQKQEQKNQLFHAVQRLQRVQN 245
            HLK+  E    H   L  I  Q + E E++    + L + +   + +L  A+Q+ + ++ 
Sbjct: 1008 HLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLET 1067

Query: 246  QLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMG 305
            +L++     A  + +S +++L+E     L  V +K    LE K   +  L   + E  M 
Sbjct: 1068 ELQN-----AHGELKSTLRQLQE-----LRDVLQKAQLSLEEKYTTIKDLTAELRECKME 1117

Query: 306  HSD----LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEE 361
              D    LLE++  + E N E+                     +Q+A+ ++       E 
Sbjct: 1118 IEDKKQELLEMDQALKERNWEL---------------------KQRAAQVTHLDMTIREH 1156

Query: 362  LQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAEL 421
              E ++K+  LE        + +E +       D+ +    +LR K  +  +  Q I++L
Sbjct: 1157 RGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQL 1216

Query: 422  KAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGR 481
            K E   ++RT++ +K+    +++Q Q          Y  TQ + E +             
Sbjct: 1217 KKE---IERTQQRMKEMESVMKEQEQ----------YIATQYK-EAI------------- 1249

Query: 482  TLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECD-------EKKSQYDS 534
               D+ + ++     V    + LA    +  Q +++ + L+ E +       EK +  + 
Sbjct: 1250 ---DLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNH 1306

Query: 535  CAAGLESNR-------SKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKA 587
             A  L +++       ++++ E+++L  E    +  YH      +    + + + D  K+
Sbjct: 1307 LAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKS 1366

Query: 588  YIS--SDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESH 629
             +   ++Q EK K   E+     +   NL ++++++ +VI  ++
Sbjct: 1367 SVQQLNEQLEKAKLELEEAQDTVS---NLHQQVQDRNEVIEAAN 1407



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 59/261 (22%), Positives = 123/261 (47%), Gaps = 20/261 (7%)

Query: 115  RAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKD 174
            R  + + +IKLE   E  + E + + NKQ E L +    L    EQL+   F   +  ++
Sbjct: 1157 RGEMEQKIIKLEGTLEKSELE-LKECNKQIESLNDK---LQNAKEQLREKEFIMLQNEQE 1212

Query: 175  ISAMEEEKD---QLIKRVEHLKKRVET--AQNHQWMLKIARQLRVEKEREEYLAQQKQEQ 229
            IS +++E +   Q +K +E + K  E   A  ++  + + ++LR+ +E+ +    +  E 
Sbjct: 1213 ISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEA 1272

Query: 230  KNQLFHAVQRLQRVQNQLKSMRQAA--ADAKPESLMKRL------EEEIKFNLYMVTEKF 281
            ++Q   A + ++R+ ++L+ M+Q +   DA    L + L      E  ++  +    +K 
Sbjct: 1273 RHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKL 1332

Query: 282  PKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKL 341
              E+E+ K+  H   +++S         +  +S+ + +  ++N+ +EK  +  E  +  +
Sbjct: 1333 SAEVESLKEAYH--MEMISHQENHAKWKISADSQKSSVQ-QLNEQLEKAKLELEEAQDTV 1389

Query: 342  SLYRQQASIISRKKEAKAEEL 362
            S   QQ    +   EA  E L
Sbjct: 1390 SNLHQQVQDRNEVIEAANEAL 1410



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 67/375 (17%), Positives = 155/375 (41%), Gaps = 50/375 (13%)

Query: 300 SEPAMGHSDLLELESKINEINTEINQLIEKKMMRNE-PIEGKLSLYRQQASIISRKKEAK 358
           S P + +    E   KI+  +T+  +    KM  +  P++ ++   R++ + + ++    
Sbjct: 189 SHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACL 248

Query: 359 AEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQII 418
             +      K  S+  E +  R +    +  +              +  ++V   + QII
Sbjct: 249 VTQNHSLMTKFESIHFELTQSRAKVSMLESAQ--------------QQAASVPILEEQII 294

Query: 419 ---AELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEV 475
              AE+ A+  +L+  E  L+Q  + + ++ Q+++E K         EE  ++       
Sbjct: 295 NLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESK---------EECIKLKV----- 340

Query: 476 DEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSC 535
                    D+ E  K+      ++  AL +      +L + +Q+  ++  EK  +  + 
Sbjct: 341 ---------DLLEQTKQGKRAERQRNEALYNA----EELSKAFQQYKKKVAEKLEKVQAE 387

Query: 536 AAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMK--AYISSDQ 593
              LE N +  E+E +RL+E C   +S        ++ L+ +     ++++  A  +S+ 
Sbjct: 388 EEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEV 447

Query: 594 QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCF 653
             +    R+   K  +E EN  + LR+K  ++ E+    ++ A      E+L  C+++  
Sbjct: 448 MAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVA---AQNERLDLCQQEIE 504

Query: 654 LKQQSQTSIGQVIQE 668
             +    S+ ++I +
Sbjct: 505 SSRVELRSLEKIISQ 519


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 121/603 (20%), Positives = 270/603 (44%), Gaps = 72/603 (11%)

Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAE 170
           ELK++   A+FL+  +V +  LQ+E      +Q EEL E  K + K+ E++         
Sbjct: 250 ELKRKLERAKFLLP-QVQTNTLQEEMW----RQEEELREQEKKIRKQEEKM---WRQEER 301

Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKER----EEYLAQQK 226
           +R+    M E+++++ ++ + L+++ +  +  +  L+  ++LR ++E+    EE + +Q+
Sbjct: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361

Query: 227 Q---EQKNQLFHAVQRLQRVQNQLKSMRQAAADAKP-----ESLMKRLEEEIKFNLYMVT 278
           +   EQ+ +++   +RL   + Q++   Q   D +      +  ++  EE ++    M  
Sbjct: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 421

Query: 279 EKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPI- 337
           +      E K +E     +   E       + E E K+ E    + +  EK   + E + 
Sbjct: 422 QVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 481

Query: 338 EGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLE-----------------REASVKR 380
           E +   ++QQ     ++K  + E++QE +EK+   E                 R+  ++ 
Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 541

Query: 381 NQTREFDGTEVLKGDEFKRY--VNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQR 438
            + + ++  E ++  E K +    ++  K+   +KK     E   E   ++  E+ +++ 
Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601

Query: 439 HENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD---MSEMVKKLYS 495
            E +++Q + M+E++        QE+ E++   + ++ E + +  +    M E  +K++ 
Sbjct: 602 EEMMREQEEKMQEQE-----EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656

Query: 496 L--VSEKKSALASVIKELRQLRQKYQE---LTQECDEKKSQYDSCAAGLESNRSKLEQEV 550
              + E+K  L    K   Q + + QE     QE  EKK+Q        E  +   +QE 
Sbjct: 657 QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQ--------EQEKKTWDQEK 708

Query: 551 RRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAE 610
            R  E   + E +      M++  E +++   ++M        QE+ + + EQ  K   +
Sbjct: 709 MREEESMREREKKMREEEEMMREQEEKMQEQEEKM--------QEQEEEMWEQEEKMWEQ 760

Query: 611 QENLGKKLR-EKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEG 669
           +E + ++ R  +QK     H    +Q K+W   E++ + +++  ++ Q +   GQ  +  
Sbjct: 761 EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEK--MRGQEEKMRGQEEKMR 818

Query: 670 GED 672
           G++
Sbjct: 819 GQE 821



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 103/501 (20%), Positives = 225/501 (44%), Gaps = 56/501 (11%)

Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE---REEYLAQQ 225
           AE+++ +   E EK ++   V+ LK+++E A   +++L   +   +++E   +EE L +Q
Sbjct: 228 AELQEKLPLAESEKSEIQLNVKELKRKLERA---KFLLPQVQTNTLQEEMWRQEEELREQ 284

Query: 226 KQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKEL 285
           +++ + Q     ++ +R++ Q   MR+   + K     KRL E+             KEL
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMRE--QEEKMWRQEKRLREQ------------EKEL 330

Query: 286 ENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYR 345
             ++KEL   QK + E       + E E K+ E   ++ +  EK   + E +  +    R
Sbjct: 331 REQEKELR-EQKELREQ---EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386

Query: 346 QQASIIS-------------RKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVL 392
           +Q   +              R+KE +  E ++  E++  +  E  ++  + +  D  E +
Sbjct: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446

Query: 393 KGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEK 452
           + +E      ++R +    +++ + + E + +   +Q+ EE + ++ E   QQ +  E+K
Sbjct: 447 QEEE------RIREREKKMREEEETMREQEEK---MQKQEENMWEQEEKEWQQQRLPEQK 497

Query: 453 KGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLY--SLVSEKKSALASVIKE 510
           + +      QE+ E++        E K R  ++M    KK++    + E++  +    ++
Sbjct: 498 EKLWEQEKMQEQEEKIWE-----QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552

Query: 511 LRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCM 570
           +R   QK  +  +E  EKK+Q        +  + + E+ +R   ++  +EE         
Sbjct: 553 MRDQEQKMWD-QEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611

Query: 571 IKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLR-EKQKVIRESH 629
           ++  E +++   ++M        QE+ + + EQ  K   ++E + ++ R  +QK     H
Sbjct: 612 MQEQEEKMQEQEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670

Query: 630 GPNMKQAKMWRDLEQLMECKK 650
               +Q KM    E++ E +K
Sbjct: 671 EKMQEQEKMQEQEEKIWEQEK 691



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 94/432 (21%), Positives = 191/432 (44%), Gaps = 63/432 (14%)

Query: 234 FHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELH 293
           +H    LQR  + + S R   AD   E L K   + +   LY  T    +EL+ K  EL 
Sbjct: 175 WHFAGELQRALSAV-STRHKKADRYIEELTKE-RDALSLELYRNTIT-NEELKKKNAELQ 231

Query: 294 FLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISR 353
                          L   ES+ +EI   + +L ++K+ R      K  L + Q + +  
Sbjct: 232 -------------EKLPLAESEKSEIQLNVKEL-KRKLER-----AKFLLPQVQTNTLQE 272

Query: 354 KKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKK 413
           +   + EEL+E ++K+   E +   +  + RE +G    + ++  R   +LR +    ++
Sbjct: 273 EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELRE 332

Query: 414 KHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKS 473
           + + + E K     L+  EE ++++ E + +Q + M E++      + QEE  R+   + 
Sbjct: 333 QEKELREQKE----LREQEEQMQEQEEKMWEQEEKMREQEE---KMWRQEE--RLWEQEK 383

Query: 474 EVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYD 533
           ++ E + +  D    M         E+   L    + +R+  + ++++ +  +EKK Q  
Sbjct: 384 QMREQEQKMRDQEERMW--------EQDERLREKEERMREQEKMWEQVEKMREEKKMQ-- 433

Query: 534 SCAAGLESNRSKLEQEVR-RLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSD 592
                        EQE + R +EE +QEE R       ++  E  +R   ++M+    + 
Sbjct: 434 -------------EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 480

Query: 593 QQEKRKAIREQ----YTKNTAEQENL---GKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645
            +++ K  ++Q      +   EQE +    +K+ E+++ IR+      ++ KMWR  E++
Sbjct: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ-EKM 539

Query: 646 MECKKQCFLKQQ 657
            E + Q + +++
Sbjct: 540 REQEDQMWEQEE 551



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 58/247 (23%), Positives = 110/247 (44%), Gaps = 48/247 (19%)

Query: 426 GLLQRTEELLKQRHENIQQQLQTM-EEKKGISGYSY----TQEELERVSALKSEVDEMKG 480
           G LQR    +  RH+   + ++ + +E+  +S   Y    T EEL++ +A          
Sbjct: 179 GELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNA---------- 228

Query: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540
                  E+ +KL  L   +KS +   +KEL++  ++ + L  +      Q +      E
Sbjct: 229 -------ELQEKL-PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ--E 278

Query: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600
               + E+++R+  E+  ++E R       ++  E ++ R    ++        E+ K +
Sbjct: 279 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLR--------EQEKEL 330

Query: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQ--------AKMWRDLEQLMECKKQC 652
           REQ  K   EQ    K+LRE+++ ++E      +Q         KMWR  E+L E +KQ 
Sbjct: 331 REQ-EKELREQ----KELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ- 384

Query: 653 FLKQQSQ 659
            +++Q Q
Sbjct: 385 -MREQEQ 390



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 46/187 (24%), Positives = 88/187 (47%), Gaps = 29/187 (15%)

Query: 485 DMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRS 544
           D++  +   +    E + AL++V    ++  +  +ELT+E D         A  LE  R+
Sbjct: 166 DLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERD---------ALSLELYRN 216

Query: 545 KLEQEVRRLREECLQE-----ESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE---- 595
            +  E  + +   LQE     ES        +K L+ +L RA   +    ++  QE    
Sbjct: 217 TITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWR 276

Query: 596 KRKAIREQYTKNTAEQENLGK---KLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQC 652
           + + +REQ  K   ++E + +   +LRE++  +RE      ++ KMWR  ++L E +K+ 
Sbjct: 277 QEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE------QEEKMWRQEKRLREQEKE- 329

Query: 653 FLKQQSQ 659
            L++Q +
Sbjct: 330 -LREQEK 335


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 123/567 (21%), Positives = 258/567 (45%), Gaps = 80/567 (14%)

Query: 146  ELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHL-KKRVETAQNHQW 204
            E++   K L + ++++K       ++++    ++ E DQL + ++ +  K +ET +    
Sbjct: 1422 EMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE--- 1478

Query: 205  MLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMK 264
             LK+A      KE+EE +     E +  L      +  +Q QL+++     D     + +
Sbjct: 1479 -LKVAHCCL--KEQEETI----NELRVNLSEKETEISTIQKQLEAIN----DKLQNKIQE 1527

Query: 265  RLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEIN 324
              E+E +FN+  ++E   K  E K+ + H   K  +  ++  S +LEL +++ E   EI 
Sbjct: 1528 IYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI-ESKMLELTNRLQESQEEIQ 1586

Query: 325  QLI-EKKMMRNEPIEGKLSLYRQQAS-----IISRKKEAKAEELQ--------EAKEKLA 370
             +I EK+ M+   ++  L + R Q       I+++ KE++ +E Q        E +EK+ 
Sbjct: 1587 IMIKEKEEMKR--VQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC 1644

Query: 371  SLE--------REASVKRNQTREFDGTEVLKGD-EFKRYVNKLRS-----KSTVFKKKHQ 416
             +E        ++ +++  +T     T++L  + E  R V K R      + T+  ++ Q
Sbjct: 1645 EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQ 1704

Query: 417  IIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGI-----SGYSYTQEELERVS-A 470
            +   L+         +E LK  H ++++  +T+++ +GI     +  S  Q++LE  + A
Sbjct: 1705 LKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDA 1764

Query: 471  LKSEVDEMKGRT------LDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQE 524
            LK++  +++         L +  E + KL  +VSEK   L+++ K+L     K QE  QE
Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824

Query: 525  CDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDE 584
                + Q  +    +   + K+  E+ +L+++   +            NL  +L    +E
Sbjct: 1825 LKANEHQLITLKKDVNETQKKV-SEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEE 1883

Query: 585  MKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQ 644
            MK+ +                    E++NL +++ E  K+ R+    ++++ K  RDLE 
Sbjct: 1884 MKSVMK-------------------ERDNL-RRVEETLKLERDQLKESLQETKA-RDLEI 1922

Query: 645  LMECKKQCFLKQQSQTSIGQVIQEGGE 671
              E K    L ++ + ++ ++ ++  E
Sbjct: 1923 QQELKTARMLSKEHKETVDKLREKISE 1949



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 125/594 (21%), Positives = 255/594 (42%), Gaps = 100/594 (16%)

Query: 145  EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQW 204
            E +     +L  +Y+ L +        ++++    +EK+ L    E L+++ +  Q  Q 
Sbjct: 494  ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDL-DEFEALERKTKKDQEMQL 552

Query: 205  MLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMK 264
            + +I+    + K  E Y     Q+ +N+L   V+ L+  ++Q+K +++     K    ++
Sbjct: 553  IHEISNLKNLVKHAEVY----NQDLENELSSKVELLREKEDQIKKLQEYIDSQK----LE 604

Query: 265  RLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV----SEPAMGHSDLLELESKINEIN 320
             ++ ++ ++L  + +  PK++   K+ L   + V      E A   S+ LEL+ K+ E+ 
Sbjct: 605  NIKMDLSYSLESIED--PKQM---KQTLFDAETVALDAKRESAFLRSENLELKEKMKELA 659

Query: 321  TEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEA--------------- 365
            T   Q+           E  + LY+ Q     + +    +ELQ A               
Sbjct: 660  TTYKQM-----------ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV 708

Query: 366  -KEKLASLEREASV---KRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAEL 421
             K+ L +LE E  +   ++   +E +  E L+ +     +++L+S  +  ++  + I + 
Sbjct: 709  PKDLLCNLELEGKITDLQKELNKEVEENEALREEVI--LLSELKSLPSEVERLRKEIQDK 766

Query: 422  KAEFGLLQRTEELLKQRHENIQQQLQTMEEKKG---------ISGYSYTQEELERVSALK 472
              E  ++   ++ L     + + ++Q + E+ G          S Y  T +E +    L 
Sbjct: 767  SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH 826

Query: 473  SEVDEMKGRTLDDMSEMVKKLYSLVSEKK---SALASVIKELRQLRQKYQELTQECDEKK 529
             + ++     L++   M +++ +L  E +   S+L ++  EL    Q+ QE T+E  E+ 
Sbjct: 827  MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL 886

Query: 530  SQYDSCAAGLESNRSKLE-----------------QEVRRLREE-----CLQE------- 560
            ++ +     LE+  S L+                 +EV+ L +E      LQE       
Sbjct: 887  NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD 946

Query: 561  --ESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKL 618
              +S  H T  M  + + QLR A + +K +  +    K K I E+ ++N   +EN G+  
Sbjct: 947  QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSK-ISEEVSRNLHMEENTGETK 1005

Query: 619  RE-KQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGE 671
             E +QK++    G + KQ    ++ + L    K   + +Q Q  I  +IQE  E
Sbjct: 1006 DEFQQKMV----GIDKKQDLEAKNTQTLTADVKDNEIIEQ-QRKIFSLIQEKNE 1054



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 116/548 (21%), Positives = 237/548 (43%), Gaps = 68/548 (12%)

Query: 145  EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKR---VEHLK-KRVETAQ 200
            E+L E  + L ++ +QL       +E++K I+ +E  K++L  +   +EH++ +R+E AQ
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQ 1186

Query: 201  ----NHQWMLKIARQLRVEKEREEYLA------------------QQKQEQKNQLFHAVQ 238
                N++ +  I ++ +V KE ++                     Q K+E K    H  +
Sbjct: 1187 KLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKE 1246

Query: 239  RLQRVQNQLKSMRQAAADA-KPESLMK---RLEEEIKFNLYMVTEKFP--KELENKKKEL 292
              + +    +S+ +  A     + L K   +L+EEI   L+   E  P  KE+   ++ +
Sbjct: 1247 HQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPV-LHEEQELLPNVKEVSETQETM 1305

Query: 293  HFLQKVVSEPAMGHS--------DLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLY 344
            + L+ +  +     S        + L L  K  E   EI  L  K+    + I+  L + 
Sbjct: 1306 NELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLT-KERDNLKTIKEALEVK 1364

Query: 345  RQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKL 404
              Q     R+  AK +E Q  +E+  +++ + +       E +  +  K     R   ++
Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKP-KDSALLRIEIEM 1423

Query: 405  RSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEE 464
               S   ++ H  +  +  E   LQR +E+L+   + +++ +     K+ ++ +  T+EE
Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI-----KEIVAKHLETEEE 1478

Query: 465  LERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQE 524
            L+                L +  E + +L   +SEK++ ++++ K+L  +  K Q   QE
Sbjct: 1479 LKVAHCC-----------LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE 1527

Query: 525  CDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDE 584
              EK+ Q++       S   +   E+++ +E    ++S        +  L  +L+ + +E
Sbjct: 1528 IYEKEEQFNIKQI---SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEE 1584

Query: 585  MKAYISSDQQEKR-----KAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMW 639
            ++  I   ++ KR     +  R+Q  +NT E     K+ +EK+    +    N  Q KM 
Sbjct: 1585 IQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC 1644

Query: 640  RDLEQLME 647
             ++E L E
Sbjct: 1645 -EIEHLKE 1651



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 117/578 (20%), Positives = 250/578 (43%), Gaps = 88/578 (15%)

Query: 136  TVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKR 195
            T     K  ++  + FKTLH ++EQ                 + EE +++ + + +L K 
Sbjct: 807  TTQSNYKSTDQEFQNFKTLHMDFEQ-------------KYKMVLEENERMNQEIVNLSKE 853

Query: 196  VETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAA 255
             +         K    L   K    Y  Q+ QE+  ++   +  +++++ QL++      
Sbjct: 854  AQ---------KFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR----- 899

Query: 256  DAKPESLMKRLEEEIKFNLYMVTEKFPKELE------NKKKELHFLQKVVS-EPAMGHSD 308
                +S ++ +E E      ++TEK  + LE       +K +L  LQ+ +  E     SD
Sbjct: 900  ----DSTLQTVERE----KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSD 951

Query: 309  LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEK 368
            + +  +   +   ++   +E      E I    S   ++ S     +E   E   E ++K
Sbjct: 952  IHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQK 1011

Query: 369  LASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL 428
            +  ++++  ++   T+    T  +K +E    + + R   ++ ++K+++   L++   ++
Sbjct: 1012 MVGIDKKQDLEAKNTQTL--TADVKDNEI---IEQQRKIFSLIQEKNELQQMLES---VI 1063

Query: 429  QRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEEL---ERVSALKSEVDEMKGRTLDD 485
               E+L     ENI+  ++  EE + +      Q+E+   E+  A+K E +    RT D 
Sbjct: 1064 AEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE--LSRTCDR 1121

Query: 486  MSEMVKKL---YSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESN 542
            ++E+ +KL      + EK+  L +V +E+ ++++K  E+    +E K++ +     +E+ 
Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNK-ELTLEHMETE 1180

Query: 543  RSKLEQEVRRLREE---------CLQE-----ESRYHYTNCMIKNLEVQLRRATDEMK-- 586
            R +L Q++    EE          L+E     E+   +    I+ +E    +  +E+K  
Sbjct: 1181 RLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240

Query: 587  -AYISSDQQ---EKRKAIREQYTK--NTAEQENLGKKLREKQKVIRESHG--PNMKQAKM 638
              ++   Q+   E R+++ E+  +  NT + E    KL+E+  V+ E     PN+K+   
Sbjct: 1241 HIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300

Query: 639  WRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDRLIL 676
             ++    +E      L +QS T     +     +RL L
Sbjct: 1301 TQETMNELE-----LLTEQSTTKDSTTLARIEMERLRL 1333



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 109/561 (19%), Positives = 230/561 (40%), Gaps = 78/561 (13%)

Query: 135  ETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKK 194
            E V    ++ ++L +  ++L  E +QLK      ++I   ++   + ++QL   +E LK+
Sbjct: 922  EEVKTLTQEKDDLKQLQESLQIERDQLK------SDIHDTVNMNIDTQEQLRNALESLKQ 975

Query: 195  RVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN-QLKSMRQA 253
              ET         +  ++  E  R  ++ +   E K++    +  + + Q+ + K+ +  
Sbjct: 976  HQETINT------LKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL 1029

Query: 254  AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELE 313
             AD K   ++++              K    ++ K +    L+ V++E     +DL E  
Sbjct: 1030 TADVKDNEIIEQ------------QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENI 1077

Query: 314  SKINEINTEINQLIEKKMMRNEPI----------EGKLSLYRQQASIISRKKEAKAEELQ 363
                E   E+  L ++   + E +          EG+LS    + + +  K + K+++LQ
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137

Query: 364  EAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKA 423
            E +++L +++ E S  + +  E +  +    +E K     L    T   +  Q + E   
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLK----NELKNKELTLEHMETERLELAQKLNENYE 1193

Query: 424  EFGLLQRTEELLKQRHENIQQQ---------------LQTMEEKKGISGYSYTQEELERV 468
            E   + +  ++LK+  ++ + +               LQT EE K    + + +E  E +
Sbjct: 1194 EVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELK--IAHIHLKEHQETI 1251

Query: 469  SALKSEVDEMKGRTLD--DMSEMVKKLYS--LVSEKKSALASVIKELRQLRQKYQELTQE 524
              L+  V E   + ++  D+ +   KL     V  ++  L   +KE+ + ++   EL   
Sbjct: 1252 DELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELL 1311

Query: 525  CDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEV---QLRRA 581
             ++  ++  +  A +E  R +L ++ +  +EE             + + LEV   QL+  
Sbjct: 1312 TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH 1371

Query: 582  TDEMKAYISSDQQEKRKAIR-----EQYTKNTAEQENLGKK----------LREKQKVIR 626
              E  A I   Q ++ +++       + TK  +E E    K          +    K ++
Sbjct: 1372 IRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQ 1431

Query: 627  ESHGPNMKQAKMWRDLEQLME 647
            ESH      AK   DL++L E
Sbjct: 1432 ESHDEMKSVAKEKDDLQRLQE 1452



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 150/726 (20%), Positives = 317/726 (43%), Gaps = 116/726 (15%)

Query: 27   DSLEPMQ-LLQVLSDVLAEIDPKQLVDIREEMPEQTA------KRMLSLLGILKYKPSGN 79
            D L+ +Q +LQ  SD L E + K++V    E  E+        K     +  L+   S  
Sbjct: 1445 DDLQRLQEVLQSESDQLKE-NIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEK 1503

Query: 80   ATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKR---AYLARFLIKLEVPSEFLQDET 136
             T++ST ++ L       I   L   +Q   E +++     ++    K+    +F +   
Sbjct: 1504 ETEISTIQKQL-----EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRK 1558

Query: 137  VADTNKQYEE--LMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKK 194
              D+  Q  E  ++E    L +  E+++I      E+++   A++ E+DQL +  + +  
Sbjct: 1559 AKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA 1618

Query: 195  RVETAQN--HQWMLKIARQLRVEKERE-EYLAQQKQEQKNQLFHA----VQRLQRVQNQL 247
            +++ +Q   +Q++   A     EK  E E+L +Q + QK  L +     ++  Q +   L
Sbjct: 1619 KMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENL 1678

Query: 248  KSMRQAAADAKP----ESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPA 303
            + MR    +       E  +K   +++K NL    E   ++LE K++EL    K+V    
Sbjct: 1679 EEMRSVTKERDDLRSVEETLKVERDQLKENL---RETITRDLE-KQEEL----KIVHMHL 1730

Query: 304  MGHSDLLE-LESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEEL 362
              H + ++ L   ++E   EI+ + +     N+ ++ +    +++  I     + + E +
Sbjct: 1731 KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790

Query: 363  Q-------EAKEKLASLEREASVKRNQTREFDGTEVLKGDE-----FKRYVNKLRSKSTV 410
                    E  +KL++++++  ++ +  +  +  + LK +E      K+ VN+ + K + 
Sbjct: 1791 DKLRGIVSEKTDKLSNMQKD--LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVS- 1847

Query: 411  FKKKHQIIAELKAEFGLLQRTE----ELLKQRHENIQQQLQTMEEKKGISGYSYTQEELE 466
              +  Q+  ++K +   L + E     L ++ HEN+++    M+E+  +     T + LE
Sbjct: 1848 --EMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK-LE 1904

Query: 467  RVSALKSEVDEMKGRTLDDMSEM-------------VKKLYSLVSEKKSALASVIKEL-- 511
            R   LK  + E K R L+   E+             V KL   +SEK   ++ + K+L  
Sbjct: 1905 R-DQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDK 1963

Query: 512  --RQLRQKYQELTQ--------------------ECDEKKSQYDSCAAGLESNRSKLEQE 549
               +L++K QEL +                    E ++ K Q+++    ++S R    Q 
Sbjct: 1964 SKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQL 2023

Query: 550  VRRLREECLQEESRYHYTNCMIKNLEVQLRRATDE----MKAYISSDQQEKRKAIREQYT 605
             ++L E  L+E          ++ ++  L+   D+    ++  I+ D+Q  +  ++ +  
Sbjct: 2024 TKKLHES-LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ--VKPEKR 2080

Query: 606  KNTAEQENLGKKLREKQKVIRE---------SHGPNMKQAKMWRDLEQLMECKKQCFLKQ 656
              +  Q++L + LREK   I+E          H   + +  +  DLE+ +E +K+  ++ 
Sbjct: 2081 LLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSL--DLEKEIEFQKELSMRV 2138

Query: 657  QSQTSI 662
            ++  S+
Sbjct: 2139 KANLSL 2144



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 136/636 (21%), Positives = 267/636 (41%), Gaps = 128/636 (20%)

Query: 144  YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAME-----EEKDQLIKRVEHLKKRVET 198
            Y+ L+  ++ L  E E++++      ++  +  A+E     +++ QLI  + +LK  V+ 
Sbjct: 507  YDNLVLDYEQLRTEKEEMELKLKEKNDL-DEFEALERKTKKDQEMQLIHEISNLKNLVKH 565

Query: 199  AQNHQWMLKIARQLRVE---------KEREEYLAQQKQEQ-KNQLFHAVQRLQ---RVQN 245
            A+ +   L+     +VE         K+ +EY+  QK E  K  L ++++ ++   +++ 
Sbjct: 566  AEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQ 625

Query: 246  QLKSMRQAAADAKPESLMKR---LEEEIKFNLYMVTEK--------FPKELENKKKELHF 294
             L      A DAK ES   R   LE + K      T K        +  +LE KKK    
Sbjct: 626  TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD 685

Query: 295  LQKVVSEPAMGHSDL---------------LELESKINEINTEINQLIEK-KMMRNEPIE 338
            L+K +       + L               LELE KI ++  E+N+ +E+ + +R E I 
Sbjct: 686  LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL 745

Query: 339  -GKLSLYRQQASIISRKKEAKAEELQ---EAKEKLAS--LEREASVK------------- 379
              +L     +   + ++ + K+EEL      K+KL S  + +E+ V+             
Sbjct: 746  LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805

Query: 380  -------RNQTREFDGTEVLKGD----------EFKRYVNKLRSKSTVFKKKHQIIAELK 422
                   ++  +EF   + L  D          E +R   ++ + S   +K    +  LK
Sbjct: 806  ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK 865

Query: 423  AEFG-----LLQRTEEL---------LKQRHENIQQQLQTMEEKKGISGYSYTQEELERV 468
             E       L ++T E+         LK++ EN    LQT+E +K +      Q+ LE V
Sbjct: 866  TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLI-TEKLQQTLEEV 924

Query: 469  SALKSEVDEMK----------GRTLDDMSEMVKKLYSLVSEKKSALASVIKE---LRQLR 515
              L  E D++K           +   D+ + V        + ++AL S+ +    +  L+
Sbjct: 925  KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK 984

Query: 516  QKYQE-------LTQECDEKKSQYDSCAAGLESNRSKLEQEVRRL----REECLQEESRY 564
             K  E       + +   E K ++     G++  +    +  + L    ++  + E+ R 
Sbjct: 985  SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRK 1044

Query: 565  HYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKV 624
             ++    KN   Q+  +    K  + +D +E      E   +N  E   LG +L+++Q++
Sbjct: 1045 IFSLIQEKNELQQMLESVIAEKEQLKTDLKEN----IEMTIENQEELRLLGDELKKQQEI 1100

Query: 625  I-RESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659
            + +E +    K+ ++ R  ++L E +++  LK++SQ
Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEK--LKEKSQ 1134



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 90/450 (20%), Positives = 173/450 (38%), Gaps = 79/450 (17%)

Query: 126  EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185
            E PS   + + V    K+  + +E +     + E+LK             + +++E D++
Sbjct: 2250 EFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLK-------------NGIQKENDRI 2296

Query: 186  IKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN 245
             +       R+    N     +  R   + KE E+ L   K E+  +LF   Q L+    
Sbjct: 2297 CQVNNFFNNRIIAIMNESTEFE-ERSATISKEWEQDLKSLK-EKNEKLFKNYQTLKTSLA 2354

Query: 246  QLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELEN-----KKKELHFLQKVVS 300
                +     D K   +  R  +       + TEK  +ELEN     K+  +H   K++ 
Sbjct: 2355 SGAQVNPTTQDNKNPHVTSRATQ-------LTTEKI-RELENSLHEAKESAMHKESKIIK 2406

Query: 301  ---EPAMGHSDLLELESKINEINT-------EINQLIEKKMMRNEPIEGKLSLYRQQASI 350
               E  + +  + +L++K++E N         I  L +K  +  +P + ++   + +   
Sbjct: 2407 MQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVK 2466

Query: 351  ISRKKEAKAEELQ-EAKEKLASLEREASVKR------NQTREFDGTEVLKGDEFKRYVNK 403
            I  +K   A+E + E     A++E +  V R       ++++   T V+      +  NK
Sbjct: 2467 IDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNK 2526

Query: 404  -----------LRSKSTVFKKKHQIIAELKAEFGLL-QRTEELLKQRHENIQQQLQTMEE 451
                         +K+ + K +H     L+ E   L Q+ E+L+KQ++E +        E
Sbjct: 2527 PLTCGGGSGIVQNTKALILKSEH---IRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNE 2583

Query: 452  KKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKEL 511
             K     ++ +  L+R         E   +   + S    K+    S+KK    S  KE 
Sbjct: 2584 VK-----TWKERTLKR---------EAHKQVTCENSPKSPKVTGTASKKKQITPSQCKE- 2628

Query: 512  RQLRQKYQELTQECDEKKSQYDSCAAGLES 541
                +  Q+   +   K   +DS +  L S
Sbjct: 2629 ----RNLQDPVPKESPKSCFFDSRSKSLPS 2654


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 126/590 (21%), Positives = 255/590 (43%), Gaps = 76/590 (12%)

Query: 142  KQYEEL-MEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETA- 199
            KQ E L  E    L    +QL+++  +    +  ++  + EK +L ++VE L+  VETA 
Sbjct: 604  KQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETAR 663

Query: 200  -QNHQWMLKIAR---QLRVEKER---EEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ 252
             + H+   ++A    QLR E+++   +E +AQ+K + + QL    + L+  +  L+  ++
Sbjct: 664  QEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723

Query: 253  AAADAKPESLMKRLEEEIKFNLYMVTEKFP---KELENKKKELHFLQKVVSEPAMGHS-- 307
             AADA  E   +R   E+K     + E+     KELE ++     L+  + +    H   
Sbjct: 724  RAADALEEQ--QRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAE 781

Query: 308  ------DLLELESKINEINTEINQLIEKKMMRNEPIEGKL-------SLYRQQASIISRK 354
                  +L E  +  +   +E  QL+++     E  E          +++++Q   +  +
Sbjct: 782  TEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE 841

Query: 355  KEAKAEELQEAKEKLASLER----EASVKRNQTREFDGT----------EVLKGDEFKRY 400
             E   +ELQEAKEK+A +E     + S ++N+  E              + ++  +    
Sbjct: 842  CEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADD 901

Query: 401  VNKLRSKSTVFKKKHQIIAELKAEFGLLQRT--EELLKQRHENIQQQLQTMEEKKGISGY 458
            ++ L+ K     K+   +  L  + G  Q T   EL+K+      +Q + +EE++G   +
Sbjct: 902  LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG-RQF 960

Query: 459  SYTQEELE-----------RVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASV 507
              TQ  L+            +  L++ + E +G+  ++  +  +++  L  E+  A A +
Sbjct: 961  CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 1020

Query: 508  IKELRQLRQKYQELTQECDEKKSQY----DSCAAGLESNRSKLEQEVRRLREECLQEESR 563
              E     +    L    +E++ ++    ++ A  L     K +QE+ +LR         
Sbjct: 1021 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK-DQELAKLR--------- 1070

Query: 564  YHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQK 623
                   IK LE +LR+   ++K  ++  ++E       Q ++     E  G KL   + 
Sbjct: 1071 -GLEAAQIKELE-ELRQTVKQLKEQLAKKEKEHASGSGAQ-SEAAGRTEPTGPKLEALRA 1127

Query: 624  VIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQS--QTSIGQVIQEGGE 671
             + +      KQ +    LE+ +E ++    ++ S  +T  GQ+ ++  E
Sbjct: 1128 EVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 149/601 (24%), Positives = 251/601 (41%), Gaps = 98/601 (16%)

Query: 142  KQYEELMEAFKTLH-----KEYEQLKISGF-STAEIRKDISA--MEEEKDQLIKRVEHLK 193
            K+ EEL +  K L      KE E    SG  S A  R + +   +E  + ++ K  +  +
Sbjct: 1078 KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ 1137

Query: 194  KRVETAQNHQWMLKIARQLRVEKERE-EYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ 252
            K+ E A + +  L+  R  R E++   E L  Q +E+  +L H+   L   Q +L + R 
Sbjct: 1138 KQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRT 1197

Query: 253  AAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLEL 312
               D        + E+E K  +     +  +E E K   +  L++ VS   + +  +LE 
Sbjct: 1198 KVQDHS------KAEDEWKAQV----ARGRQEAERKNSLISSLEEEVS---ILNRQVLEK 1244

Query: 313  ESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASL 372
            E +    + E+ +L+  +  +++ +E +L L   QA   S    A AE     +E++ SL
Sbjct: 1245 EGE----SKELKRLVMAESEKSQKLEERLRLL--QAETASNSARA-AERSSALREEVQSL 1297

Query: 373  EREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQR-T 431
              EA  +R  +         + +  +    +L++    F +K Q ++ L+ E    Q   
Sbjct: 1298 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357

Query: 432  EELLKQRHENIQQQLQT------------MEEKKGISG-----YSYTQEELERVSALKSE 474
             ELL  +H  + QQLQ             +E+ K  +G         Q EL  +  L+ +
Sbjct: 1358 SELLPAKH--LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQK 1415

Query: 475  VDEMKGRTLDDMS----------EMVKKLYSLVSEKKSALASVIK--------ELRQLRQ 516
            V E + RT   +            M+KK + L++E+   L             EL Q R+
Sbjct: 1416 VAEQE-RTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE 1474

Query: 517  KY-QELTQ-------ECDEKKSQYDSCAAGLESNRSKLE-QEVRRLREECLQEESRYHYT 567
            KY QEL            E + +  S A  LE   +K E  +V+ L E    +E R   T
Sbjct: 1475 KYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLT 1534

Query: 568  NCMIKNLEVQLRRATDEM----KAYISSDQ-----QEKRKAIREQYTKNTAEQENLGKKL 618
               ++ LEV  R  T ++    K    SDQ     Q+K KA++ Q  ++  E + L  +L
Sbjct: 1535 -AQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQL 1593

Query: 619  REKQKVI------RESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGED 672
             E Q  +       E +   M++AK   D +     K+Q    Q+   S+ Q+ +E  E 
Sbjct: 1594 NELQAQLSQKEQAAEHYKLQMEKAKTHYDAK-----KQQNQELQEQLRSLEQLQKENKEL 1648

Query: 673  R 673
            R
Sbjct: 1649 R 1649



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 104/507 (20%), Positives = 219/507 (43%), Gaps = 47/507 (9%)

Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQK 230
           ++++ + +     QL  RVE L    ET +  Q    +A +   E+E+     QQ     
Sbjct: 418 LKQEAATLAANNTQLQARVEML----ETERGQQEAKLLAERGHFEEEK-----QQLSSLI 468

Query: 231 NQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKK 290
             L  ++  L + + +L+   QA   A+  + +  L  E+   L    ++  +EL   K+
Sbjct: 469 TDLQSSISNLSQAKEELEQASQAHG-ARLTAQVASLTSELT-TLNATIQQQDQELAGLKQ 526

Query: 291 ELHFLQKVVSEPAMGHSDLLE-LESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS 349
           +    Q  +++         + L  ++ ++++ + Q  ++     E  E     + QQ +
Sbjct: 527 QAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLA 586

Query: 350 IISRKKEAKAEELQEAKEKLASLEREASVK----------RNQTREFDGTEVLKGD---- 395
             + ++EA   E   A ++L +LE+E + K           N+ R+   T V +      
Sbjct: 587 TAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKA 646

Query: 396 EFKRYVNKLRS-KSTVFKKKHQIIAELKAEFGLLQRTE-------ELLKQRHENIQQQLQ 447
           E  R V +L++   T  +++H+  A++ AE  L  R+E       E + Q  + +Q+QLQ
Sbjct: 647 ELSRKVEELQACVETARQEQHEAQAQV-AELELQLRSEQQKATEKERVAQEKDQLQEQLQ 705

Query: 448 TMEEKKGISGYSYTQEELERVSALKSE---VDEMKGRTLDDMSEMVKKLYSLVSEKKSAL 504
            ++E   ++  S  +E+     AL+ +   + E+K  T   + E  K+    + E+++  
Sbjct: 706 ALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET-RSLVEQHKRERKELEEERAGR 764

Query: 505 ASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEV---RRLREECLQEE 561
             +   L+QL + +Q  T+    + ++  +     ES   +L +EV   R   E+  QEE
Sbjct: 765 KGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEE 824

Query: 562 SRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQEN-LGKKLRE 620
           ++Y     M +   + L+   ++ +  +  + +EK   I        + Q+N L +    
Sbjct: 825 AQY---GAMFQEQLMTLKEECEKARQEL-QEAKEKVAGIESHSELQISRQQNELAELHAN 880

Query: 621 KQKVIRESHGPNMKQAKMWRDLEQLME 647
             + +++     ++  K+  DL  L E
Sbjct: 881 LARALQQVQEKEVRAQKLADDLSTLQE 907



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 113/535 (21%), Positives = 224/535 (41%), Gaps = 74/535 (13%)

Query: 161 LKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREE 220
           L+   F    ++K ++     +D+L          +E A+N + + +   Q+ + ++R +
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDEL---------ELELAENRKLLTEKDAQIAMMQQRID 259

Query: 221 YLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEK 280
            LA   ++Q      A   L+    +L+ +R      K ESL  RL E +K    + TEK
Sbjct: 260 RLALLNEKQ------AASPLE--PKELEELRD-----KNESLTMRLHETLKQCQDLKTEK 306

Query: 281 FP-----KELENKKKELHF-----------LQKVVSEPAMGHSDLL-ELESKINEINTEI 323
                   +L  +  +L F           LQ  ++E    HS    E   K  ++  E+
Sbjct: 307 SQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKEL 366

Query: 324 NQLIEKKMM---RNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE-ASVK 379
           +  ++ K     +NE ++GKLS   +  S +      +  E+     +L +L++E A++ 
Sbjct: 367 SAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLA 426

Query: 380 RNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRH 439
            N T+     E+L+ +  ++   KL ++   F+++ Q ++ L  +          L+   
Sbjct: 427 ANNTQLQARVEMLETERGQQEA-KLLAERGHFEEEKQQLSSLITD----------LQSSI 475

Query: 440 ENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSE 499
            N+ Q  + +E+     G   T +    V++L SE+  +   T+    + +  L     E
Sbjct: 476 SNLSQAKEELEQASQAHGARLTAQ----VASLTSELTTLNA-TIQQQDQELAGLKQQAKE 530

Query: 500 KKSALASVIKELRQ----LRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLRE 555
           K++ LA  +++  Q    LR + ++L+    +K+ Q    A   E+ R    Q++    E
Sbjct: 531 KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE 590

Query: 556 ECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ--QEKRKAIREQYTKNTAEQEN 613
           E    E+     +  +K LE   +    +++      Q   E R + +   T+   E+  
Sbjct: 591 E---REASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAE 647

Query: 614 LGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQE 668
           L +K+ E Q  + E+      +A+      Q+ E + Q   +QQ  T   +V QE
Sbjct: 648 LSRKVEELQACV-ETARQEQHEAQ-----AQVAELELQLRSEQQKATEKERVAQE 696



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 116/552 (21%), Positives = 228/552 (41%), Gaps = 67/552 (12%)

Query: 132  LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEH 191
            ++  +    ++Q  EL E    L +  +Q++       ++  D+S ++E+     K V  
Sbjct: 859  IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918

Query: 192  LKKRVETAQNHQWMLK---IARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQR----VQ 244
            L+  V  A   Q       +    R    + E+L +Q+  Q      A+Q ++R    + 
Sbjct: 919  LETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG 978

Query: 245  NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304
            N+L+ +R A  +++ +   +R ++E             +E+    +E    Q  ++    
Sbjct: 979  NELERLRAALMESQGQQQEERGQQE-------------REVARLTQERGRAQADLALEKA 1025

Query: 305  GHSDL-LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ 363
              ++L + L++ +NE   E   L E         EGK     Q+ + +   + A+ +EL+
Sbjct: 1026 ARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK----DQELAKLRGLEAAQIKELE 1081

Query: 364  EAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKA 423
            E ++ +  L+ + + K  +     G +       +    KL +      K  Q   + + 
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141

Query: 424  EFGLLQRTEELLKQRHENIQQQLQTM----EEKKGISGYSYT-----QEELE----RVSA 470
            +   L+R+ E  +         L+T+    EEK    G+S +     Q EL     +V  
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201

Query: 471  LKSEVDEMKGRTLDDMSEMVKK--LYSLVSEKKSALASVI-------KELRQLRQKYQEL 521
                 DE K +      E  +K  L S + E+ S L   +       KEL++L     E 
Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEK 1261

Query: 522  TQECDEK----KSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQ 577
            +Q+ +E+    +++  S +A      S L +EV+ LREE   E+ R    N + + L  Q
Sbjct: 1262 SQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEA--EKQRVASEN-LRQELTSQ 1318

Query: 578  LRRATD---EMKAYISSDQQEKRKAIREQYTKNTAEQ---------ENLGKKLREKQKVI 625
              RA +   E+KA+     Q K +A+     ++T+ Q         ++L ++L+ +Q   
Sbjct: 1319 AERAEELGQELKAWQEKFFQ-KEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAA 1377

Query: 626  RESHGPNMKQAK 637
             + H   ++Q+K
Sbjct: 1378 EKRHREELEQSK 1389



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 93/463 (20%), Positives = 188/463 (40%), Gaps = 68/463 (14%)

Query: 124  KLEVPSEFLQDETVADTNKQYEE---LMEAFKTLHKEYEQLKISGFS-----------TA 169
            KLE     LQ ET +++ +  E    L E  ++L +E E+ +++  +             
Sbjct: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323

Query: 170  EIRKDISAMEE---EKDQLIK--RVEHLKKRVETAQ----NHQWMLKIARQLRVEKEREE 220
            E+ +++ A +E   +K+Q +   ++EH   +   ++     H      A Q   EK   E
Sbjct: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383

Query: 221  YLAQQKQEQ---KNQLFHAVQRL-------QRVQNQLKSMRQAAAD----AKPESLMKR- 265
             L Q KQ     + +L  A + L       Q+V  Q ++ +Q  A+    A+  S++K+ 
Sbjct: 1384 ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKA 1443

Query: 266  ---LEEE--------------IKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSD 308
               L EE              ++  L    EK+ +EL   + +       V   A   + 
Sbjct: 1444 HGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAR 1503

Query: 309  LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEK 368
             LE+ +   E   ++  L E++  + E    KL+   +Q  +  R++  + EEL +   K
Sbjct: 1504 ELEVMTAKYE-GAKVKVLEERQRFQEE--RQKLTAQVEQLEVFQREQTKQVEELSK---K 1557

Query: 369  LASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL 428
            LA  ++ + V++ + +           E +R   +L        +K Q     K +    
Sbjct: 1558 LADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA 1617

Query: 429  QRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSE 488
            +   +  KQ+++ +Q+QL+++E+           +EL   +       +  G    +  +
Sbjct: 1618 KTHYDAKKQQNQELQEQLRSLEQ------LQKENKELRAEAERLGHELQQAGLKTKEAEQ 1671

Query: 489  MVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQ 531
              + L + V   ++ +A   ++LR L  K+Q  T     ++ Q
Sbjct: 1672 TCRHLTAQVRSLEAQVAHADQQLRDL-GKFQVATDALKSREPQ 1713


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 109/512 (21%), Positives = 225/512 (43%), Gaps = 57/512 (11%)

Query: 178 MEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQL-RVEKERE------EYLAQQKQEQK 230
           +E EK  L K++  L+ ++  +     + ++ R + R +KE+       E L ++ +  +
Sbjct: 354 VEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGE 413

Query: 231 NQLFHAVQRLQRVQNQLKSMR--QAAADAKPESLMKRLEEEIK-----FNLYMVTEKFPK 283
            Q    + RL+ +QN   +    +  AD +   L +  E+  K      +    +E   +
Sbjct: 414 KQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKE 473

Query: 284 ELENKKKELHF-LQKVVSEPAMGHSDL---LELESK-INEINTEINQLIEKKMMRNEPIE 338
           E E ++++L    Q+ + +  + H  L   LE +S+ ++E+  + NQ++++K       E
Sbjct: 474 EAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKD------E 527

Query: 339 GKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFK 398
            K  LY     I + +KE     L +   K A  E E   K  + R+    +     E K
Sbjct: 528 LKTQLYAALQQIENLRKE-----LNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVK 582

Query: 399 RYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGY 458
             ++ +    +  KK+ +I +++K E   L+  EE+ + +    Q + + +E ++ I   
Sbjct: 583 NSLDTIHRLESELKKQSKIQSQMKVEKAHLE--EEIAELKKSQAQDKAKLLEMQESIKDL 640

Query: 459 SYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKY 518
           S  + +L    A   E +  K   L D+S++  +  S   E  + +  +  E    +++ 
Sbjct: 641 SAIRADLANKLA---EEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQREL 697

Query: 519 QELTQECDEKKSQYDSCAAGL----ESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNL 574
           ++LT      K++++     L    +  +S+ E  +R L+ E L+E++        ++ L
Sbjct: 698 KDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKL 757

Query: 575 EVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMK 634
           + Q  R T+E+     ++ + K+  ++ Q  K+  E+       REK   I E H   M+
Sbjct: 758 KSQCDRLTEEL---TQNENENKKLKLKYQCLKDQLEE-------REKHISIEEEHLRRME 807

Query: 635 QAKMWRDLEQLMECKKQCFLKQQSQTSIGQVI 666
           +A+        ++ K Q    +  Q SI  VI
Sbjct: 808 EAR--------LQLKDQLLCLETEQESILGVI 831



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 116/566 (20%), Positives = 229/566 (40%), Gaps = 55/566 (9%)

Query: 39   SDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILK-YKPSGNATDMSTFRQGLVIGSKPV 97
            S+ L E   K+  D++ +  E   +  L    + +  +      D  T +   ++  K  
Sbjct: 468  SEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDE 527

Query: 98   IYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFL--QDETVADTNKQYEEL----MEAF 151
            +   L+  LQ+   L+K   L   L K  +  E L  ++E + D      +L      + 
Sbjct: 528  LKTQLYAALQQIENLRKE--LNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSL 585

Query: 152  KTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQ 211
             T+H+   +LK       +  K  S M+ EK  L + +  LKK    AQ+   +L++   
Sbjct: 586  DTIHRLESELK-------KQSKIQSQMKVEKAHLEEEIAELKK--SQAQDKAKLLEMQES 636

Query: 212  LRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKR--LEEE 269
            ++        LA +  E++      ++ L  +  Q KS  +  A    +  ++R   + E
Sbjct: 637  IKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRE 696

Query: 270  IKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELES------------KIN 317
            +K     +     K  +N ++ +   +K  SE A  H   L+ ES            ++ 
Sbjct: 697  LKDLTSSLQSVKTKHEQNIQELMKHFKKEKSE-AENHIRTLKAESLEEKNMAKIHRGQLE 755

Query: 318  EINTEINQLIEKKMMRNEPIEGKLSLYRQ--QASIISRKKEAKAEE-----LQEA----K 366
            ++ ++ ++L E ++ +NE    KL L  Q  +  +  R+K    EE     ++EA    K
Sbjct: 756  KLKSQCDRLTE-ELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLK 814

Query: 367  EKLASLERE-ASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425
            ++L  LE E  S+     +E D        +    +    S   +    H+ +AE K + 
Sbjct: 815  DQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKL 874

Query: 426  GLLQRTEELLKQRHENI-------QQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEM 478
              L    +  + R +N+       +QQL+ + E K  S      +++ER   L  E+   
Sbjct: 875  QWLCEELKERENREKNLRHQLMLCRQQLRNLTENKE-SELQCLFQQIERQEQLLDEIHRE 933

Query: 479  KGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAG 538
            K   L++     +++ SL  ++  AL +  +      +   E     ++ K   DSC++ 
Sbjct: 934  KRDLLEETQRKDEEMGSL-QDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSS 992

Query: 539  LESNRSKLEQEVRRLREECLQEESRY 564
              ++    +  VRR   +  Q++++Y
Sbjct: 993  ERTDGRYSKYRVRRNSLQHHQDDTKY 1018



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 65/346 (18%), Positives = 138/346 (39%), Gaps = 51/346 (14%)

Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQ-QASIISRKKEAKAEELQEAKEK 368
           +E+  K+N I + + Q   + + + + + G+   Y   QA  I   KE+  + + + + +
Sbjct: 35  VEVTEKVNTITSTL-QDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQ 93

Query: 369 LA---SLEREASVKRNQTREFDG-----------TEVLKGDEFKRYVNKLRSKSTV-FKK 413
                S  R  SV      + DG           T  LK     + + ++RS++ V F +
Sbjct: 94  RLLRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQ 153

Query: 414 KHQIIAELKAEFGLLQRTEELLKQR--------HENIQQQLQTMEEKKGISGYSYTQEEL 465
           +   + +L    G  Q   +L  ++         E  ++     E K+ +   +    E 
Sbjct: 154 ETDDMTQLH---GFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEA 210

Query: 466 ERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQEC 525
           ++   +   V+    R L ++   ++    LV  ++  L  +  +L++  +K +    + 
Sbjct: 211 QKQEVVSDRVE----RRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEA---KA 263

Query: 526 DEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEM 585
           DE +    +     E+ +++LEQE+   R    Q E         ++ L  QL +A  + 
Sbjct: 264 DEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGD- 322

Query: 586 KAYISSDQQEKRKAIREQYTKNTAEQENL----GKKLREKQKVIRE 627
                      RK ++ Q ++ + +Q N     G+  R ++ V RE
Sbjct: 323 -----------RKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVERE 357


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 118/530 (22%), Positives = 240/530 (45%), Gaps = 55/530 (10%)

Query: 126 EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185
           E P + L  E    T+ +  +L    ++L K  E+L+ +  S       I  ME+E  +L
Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503

Query: 186 IKRVEHLKKR-VETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQ 244
            K+VE L+   V+  Q+ Q    +++ L  EK + E   +  +E   +    +++     
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563

Query: 245 NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304
           NQ  S  +  +    E+ +K +E+E K     +  +  KE  +K  ++ F ++ + +   
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENK-----ILHESIKETSSKLSKIEFEKRQIKKELE 618

Query: 305 GHSD----LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
            + +      ELE++++ +  E N+L++KK+   +    K+    Q+ S + R+     +
Sbjct: 619 HYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677

Query: 361 ELQEAKE---KLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQI 417
            L   K    +L SLE+E S       + D   +    E +R V  L+  S         
Sbjct: 678 TLDSFKNLTFQLESLEKENS-------QLDEENL----ELRRNVESLKCAS-------MK 719

Query: 418 IAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDE 477
           +A+L+ E   L+  +E LK+  E ++   +  E  +     SY   ++E         ++
Sbjct: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTERLE----VSYQGLDIE---------NQ 766

Query: 478 MKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAA 537
              +TL++ ++ +++L S + + +    ++ K L +L+   + L Q   E KS  +   +
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS-LEQETS 825

Query: 538 GLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISS--DQQE 595
            LE ++ +LE+E +RLR++   +++     N  I NLE + +  + E+  Y  S    +E
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885

Query: 596 KRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645
             K  +E   + T + + L   +  ++ ++ E     +K  +M  DLE+L
Sbjct: 886 LEKENKELVKRATIDIKTL---VTLREDLVSE----KLKTQQMNNDLEKL 928



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 113/568 (19%), Positives = 251/568 (44%), Gaps = 64/568 (11%)

Query: 125  LEVPSEFLQDETVADTNKQYEELMEAFK-------TLHKEYEQLKISGFSTAEIRKDISA 177
            L++ ++ LQ +T+ ++NK+ ++L    +       TL K  E+LKIS     ++ K+  +
Sbjct: 761  LDIENQRLQ-KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819

Query: 178  MEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV 237
            +E+E  QL K  + L+K               ++LR + E ++   ++   +   L    
Sbjct: 820  LEQETSQLEKDKKQLEKE-------------NKRLRQQAEIKDTTLEENNVKIGNLEKEN 866

Query: 238  QRLQRVQNQLKS--MRQAAADAKPESLMKRLEEEIK----FNLYMVTEKFPKELENK--K 289
            + L +     K   +R    + + + L+KR   +IK        +V+EK   +  N   +
Sbjct: 867  KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926

Query: 290  KELHFLQKV-VSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQA 348
            K  H L+K+ +++  + H +    +S+   + +++   ++K +   E  E K++    + 
Sbjct: 927  KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL---EIKEEKIAALEARL 983

Query: 349  SIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS 408
               +   +   +EL+  K+   +L++    ++++ R    +  + G++ K       +  
Sbjct: 984  EESTNYNQQLRQELKTVKKNYEALKQ----RQDEERMVQSSPPISGEDNKWERESQETTR 1039

Query: 409  TVFKKKHQII------AELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYT- 461
             + K K ++I      A L+AE   L+   + L+ ++ N+Q Q+  ++ +        T 
Sbjct: 1040 ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTT 1099

Query: 462  -QEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQE 520
             Q +  ++    S ++      ++  ++++ +  SL +E +    SVIKE   L+  Y  
Sbjct: 1100 LQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE----SVIKEREDLKSLYDS 1155

Query: 521  LTQECDEKKSQYDSCAAGLESNRSK---LEQEVRRLREECLQEESRYHY---TNCMIKNL 574
            L ++ ++ +  ++  A+  ES  SK   L+   + L  E    E RY+        +++L
Sbjct: 1156 LIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL 1215

Query: 575  EVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLG---KKLREKQKVIRESHGP 631
            E  L+   ++M       + +  + +  +Y K   E + L     +L ++ +V++  H  
Sbjct: 1216 EKMLKVEQEKMLL-----ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH-K 1269

Query: 632  NMKQAKMWRDLEQLMECKKQCFLKQQSQ 659
            N+K       LEQ     +   LK+Q Q
Sbjct: 1270 NLKSLLNNSKLEQTRLEAEFSKLKEQYQ 1297



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 95/462 (20%), Positives = 193/462 (41%), Gaps = 71/462 (15%)

Query: 194 KRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQA 253
           KR E+ Q+      ++ +L   K +   L Q+ +E+  QL    Q L++++ +LK ++Q 
Sbjct: 241 KRTESRQH------LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294

Query: 254 ----AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309
                +DA+   + +   + ++     V +K   E+   K+ LH              D+
Sbjct: 295 NMNLLSDARSARMYRDELDALREKAVRV-DKLESEVSRYKERLH--------------DI 339

Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ----EA 365
              ++++ E+  +   L+E K M  + +EG            +R +  K  EL+    + 
Sbjct: 340 EFYKARVEELKEDNQVLLETKTMLEDQLEG------------TRARSDKLHELEKENLQL 387

Query: 366 KEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425
           K KL  +E E  + R +  E            +    ++  K ++ +  H     L  E 
Sbjct: 388 KAKLHDMEMERDMDRKKIEEL---------MEENMTLEMAQKQSMDESLH-----LGWEL 433

Query: 426 GLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD 485
             + RT EL +   +++  ++  +   + +      Q   + V  L++ VD ++G     
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493

Query: 486 MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSK 545
           +   ++K    +S+K   L + I + +Q  Q  Q L+++  ++K+Q +     L  N  +
Sbjct: 494 LK--MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551

Query: 546 ----LEQEVRRLRE--ECLQEESRYHYTNCMIKNLEVQ---LRRATDEMKAYISSDQQEK 596
               LEQE   L +    L++ S+       +K++E +   L  +  E  + +S  + EK
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQIS-AEARVKDIEKENKILHESIKETSSKLSKIEFEK 610

Query: 597 R--KAIREQYTKNTAEQENLGKKLR--EKQKVIRESHGPNMK 634
           R  K   E Y +     E L  +L   EK+  + +    N+K
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 117/629 (18%), Positives = 255/629 (40%), Gaps = 71/629 (11%)

Query: 105  LLQRTNELKK-RAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKI 163
            L Q T++L+K +  L +   +L   +E ++D T+ + N +   L +  KTL KE    K 
Sbjct: 820  LEQETSQLEKDKKQLEKENKRLRQQAE-IKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878

Query: 164  SGFSTAEIRKDISAMEEEKDQLIK-----RVEHLKKRVETAQNHQWMLKIARQLRVEKER 218
            S     E+ K+   + +     IK     R + + ++++T Q +  + K+  +L      
Sbjct: 879  SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938

Query: 219  EEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPE---SLMKRLEEEIKFNLY 275
            +E L   +Q   +       R + ++++L+S  + + + K E   +L  RLEE   +N  
Sbjct: 939  KERLLHDEQSTDDS------RYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 992

Query: 276  MVTE-----KFPKELENKKKELHFLQKVVSEPAMGHSDLLELESK--INEINTEINQLIE 328
            +  E     K  + L+ ++ E   +Q   S P  G  +  E ES+    E+    ++LIE
Sbjct: 993  LRQELKTVKKNYEALKQRQDEERMVQS--SPPISGEDNKWERESQETTRELLKVKDRLIE 1050

Query: 329  KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDG 388
             +   N  ++ +    + Q   +  +      ++   + +  SL+ + +  + Q  +   
Sbjct: 1051 VER-NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109

Query: 389  TEVLKGDEFKRYVNK----LRSKSTVFKKKHQIIAE---LKAEFGLLQRTEELLKQRHEN 441
                   +    +N+    L  +S++  +   +I E   LK+ +  L +  E L+  HE 
Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1169

Query: 442  IQQQLQTMEEKKGISGYSYTQ----------------------EELERVSALKSEVDEMK 479
               + +++  K G    ++                        E+LE++  ++ E   ++
Sbjct: 1170 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1229

Query: 480  GRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGL 539
             +  + ++   KKL           + ++KE   L+  ++ L    +  K +       L
Sbjct: 1230 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE----QTRL 1285

Query: 540  ESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISS-----DQQ 594
            E+  SKL+++ ++L     +  ++    + +  NLE + R   D+++  +       +Q 
Sbjct: 1286 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1345

Query: 595  EKRKAI----REQYTKNTAEQENLGKKLREK---QKVIRESHGPNMKQAKMWRDLEQLME 647
             + K +    + QY     E     +KL EK   Q    +   P  +   +   + +L++
Sbjct: 1346 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIK 1405

Query: 648  CKKQCFLKQQSQTSIGQVIQEGGEDRLIL 676
             KK    ++Q   ++     +  E  L L
Sbjct: 1406 SKKDINRERQKSLTLTPTRSDSSEGFLQL 1434



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 61/296 (20%), Positives = 123/296 (41%), Gaps = 33/296 (11%)

Query: 316 INEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRK-KEAKAEELQEAKEKLASLER 374
           +N++  +IN  +E + + N+ +    SL     SI+ R+ K    E LQ+    + SL  
Sbjct: 48  LNQVMLQINPKLESQRV-NKKVNNDASLRMHNLSILVRQIKFYYQETLQQLI--MMSLPN 104

Query: 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEEL 434
              + +N   E  GTE     E K+ +  L   +   +KK + I  ++   GL   T+  
Sbjct: 105 VLIIGKNPFSE-QGTE-----EVKKLLLLLLGCAVQCQKKEEFIERIQ---GLDFDTKAA 155

Query: 435 LKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLY 494
           +    + +    + + + + +     +QE++E +  LK+    +K R +D+  E  + + 
Sbjct: 156 VAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPL--LKNMALHLK-RLIDERDEHSETII 212

Query: 495 SLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLR 554
            L  E+          L  L          C     +       L    +  + ++RRLR
Sbjct: 213 ELSEERDG--------LHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLR 264

Query: 555 EECLQEESRYHYTNCM--IKNLEVQLRRATDEMKAYISSDQ-----QEKRKAIREQ 603
           +E   EE      +C   ++ +E++L+R   E    +S  +     +++  A+RE+
Sbjct: 265 QEL--EEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 118/530 (22%), Positives = 240/530 (45%), Gaps = 55/530 (10%)

Query: 126 EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185
           E P + L  E    T+ +  +L    ++L K  E+L+ +  S       I  ME+E  +L
Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503

Query: 186 IKRVEHLKKR-VETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQ 244
            K+VE L+   V+  Q+ Q    +++ L  EK + E   +  +E   +    +++     
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563

Query: 245 NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304
           NQ  S  +  +    E+ +K +E+E K     +  +  KE  +K  ++ F ++ + +   
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENK-----ILHESIKETSSKLSKIEFEKRQIKKELE 618

Query: 305 GHSD----LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
            + +      ELE++++ +  E N+L++KK+   +    K+    Q+ S + R+     +
Sbjct: 619 HYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677

Query: 361 ELQEAKE---KLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQI 417
            L   K    +L SLE+E S       + D   +    E +R V  L+  S         
Sbjct: 678 TLDSFKNLTFQLESLEKENS-------QLDEENL----ELRRNVESLKCAS-------MK 719

Query: 418 IAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDE 477
           +A+L+ E   L+  +E LK+  E ++   +  E  +     SY   ++E         ++
Sbjct: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTERLE----VSYQGLDIE---------NQ 766

Query: 478 MKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAA 537
              +TL++ ++ +++L S + + +    ++ K L +L+   + L Q   E KS  +   +
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS-LEQETS 825

Query: 538 GLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISS--DQQE 595
            LE ++ +LE+E +RLR++   +++     N  I NLE + +  + E+  Y  S    +E
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885

Query: 596 KRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645
             K  +E   + T + + L   +  ++ ++ E     +K  +M  DLE+L
Sbjct: 886 LEKENKELVKRATIDIKTL---VTLREDLVSE----KLKTQQMNNDLEKL 928



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 112/567 (19%), Positives = 245/567 (43%), Gaps = 63/567 (11%)

Query: 125  LEVPSEFLQDETVADTNKQYEELMEAFK-------TLHKEYEQLKISGFSTAEIRKDISA 177
            L++ ++ LQ +T+ ++NK+ ++L    +       TL K  E+LKIS     ++ K+  +
Sbjct: 761  LDIENQRLQ-KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819

Query: 178  MEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV 237
            +E+E  QL K  + L+K               ++LR + E ++   ++   +   L    
Sbjct: 820  LEQETSQLEKDKKQLEKE-------------NKRLRQQAEIKDTTLEENNVKIGNLEKEN 866

Query: 238  QRLQRVQNQLKS--MRQAAADAKPESLMKRLEEEIK----FNLYMVTEKFPKELENK--K 289
            + L +     K   +R    + + + L+KR   +IK        +V+EK   +  N   +
Sbjct: 867  KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926

Query: 290  KELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS 349
            K  H L+K+         D    + +   + +++   ++K +   E  E K++    +  
Sbjct: 927  KLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL---EIKEEKIAALEARLE 983

Query: 350  IISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKST 409
              +   +   +EL+  K+   +L++    ++++ R    +  + G++ K       +   
Sbjct: 984  ESTNYNQQLRQELKTVKKNYEALKQ----RQDEERMVQSSPPISGEDNKWERESQETTRE 1039

Query: 410  VFKKKHQII------AELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYT-- 461
            + K K ++I      A L+AE   L+   + L+ ++ N+Q Q+  ++ +        T  
Sbjct: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099

Query: 462  QEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQEL 521
            Q +  ++    S ++      ++  ++++ +  SL +E +    SVIKE   L+  Y  L
Sbjct: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE----SVIKEREDLKSLYDSL 1155

Query: 522  TQECDEKKSQYDSCAAGLESNRSK---LEQEVRRLREECLQEESRYHY---TNCMIKNLE 575
             ++ ++ +  ++  A+  ES  SK   L+   + L  E    E RY+        +++LE
Sbjct: 1156 IKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE 1215

Query: 576  VQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLG---KKLREKQKVIRESHGPN 632
              L+   ++M       + +  + +  +Y K   E + L     +L ++ +V++  H  N
Sbjct: 1216 KMLKVEQEKMLL-----ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH-KN 1269

Query: 633  MKQAKMWRDLEQLMECKKQCFLKQQSQ 659
            +K       LEQ     +   LK+Q Q
Sbjct: 1270 LKSLLNNSKLEQTRLEAEFSKLKEQYQ 1296



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 95/462 (20%), Positives = 193/462 (41%), Gaps = 71/462 (15%)

Query: 194 KRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQA 253
           KR E+ Q+      ++ +L   K +   L Q+ +E+  QL    Q L++++ +LK ++Q 
Sbjct: 241 KRTESRQH------LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294

Query: 254 ----AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309
                +DA+   + +   + ++     V +K   E+   K+ LH              D+
Sbjct: 295 NMNLLSDARSARMYRDELDALREKAVRV-DKLESEVSRYKERLH--------------DI 339

Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ----EA 365
              ++++ E+  +   L+E K M  + +EG            +R +  K  EL+    + 
Sbjct: 340 EFYKARVEELKEDNQVLLETKTMLEDQLEG------------TRARSDKLHELEKENLQL 387

Query: 366 KEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425
           K KL  +E E  + R +  E            +    ++  K ++ +  H     L  E 
Sbjct: 388 KAKLHDMEMERDMDRKKIEEL---------MEENMTLEMAQKQSMDESLH-----LGWEL 433

Query: 426 GLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD 485
             + RT EL +   +++  ++  +   + +      Q   + V  L++ VD ++G     
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493

Query: 486 MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSK 545
           +   ++K    +S+K   L + I + +Q  Q  Q L+++  ++K+Q +     L  N  +
Sbjct: 494 LK--MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551

Query: 546 ----LEQEVRRLRE--ECLQEESRYHYTNCMIKNLEVQ---LRRATDEMKAYISSDQQEK 596
               LEQE   L +    L++ S+       +K++E +   L  +  E  + +S  + EK
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQIS-AEARVKDIEKENKILHESIKETSSKLSKIEFEK 610

Query: 597 R--KAIREQYTKNTAEQENLGKKLR--EKQKVIRESHGPNMK 634
           R  K   E Y +     E L  +L   EK+  + +    N+K
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 120/629 (19%), Positives = 256/629 (40%), Gaps = 72/629 (11%)

Query: 105  LLQRTNELKK-RAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKI 163
            L Q T++L+K +  L +   +L   +E ++D T+ + N +   L +  KTL KE    K 
Sbjct: 820  LEQETSQLEKDKKQLEKENKRLRQQAE-IKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878

Query: 164  SGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI-ARQLRVEKEREEYL 222
            S     E+       E+E  +L+KR     K + T +      K+  +Q+  + E+  + 
Sbjct: 879  SCVRLKEL-------EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931

Query: 223  AQQKQEQKNQLFHAVQ----RLQRVQNQLKSMRQAAADAKPE---SLMKRLEEEIKFNLY 275
             ++    K +L H  Q    R + ++++L+S  + + + K E   +L  RLEE   +N  
Sbjct: 932  LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991

Query: 276  MVTE-----KFPKELENKKKELHFLQKVVSEPAMGHSDLLELESK--INEINTEINQLIE 328
            +  E     K  + L+ ++ E   +Q   S P  G  +  E ES+    E+    ++LIE
Sbjct: 992  LRQELKTVKKNYEALKQRQDEERMVQS--SPPISGEDNKWERESQETTRELLKVKDRLIE 1049

Query: 329  KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDG 388
             +   N  ++ +    + Q   +  +      ++   + +  SL+ + +  + Q  +   
Sbjct: 1050 VER-NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108

Query: 389  TEVLKGDEFKRYVNK----LRSKSTVFKKKHQIIAE---LKAEFGLLQRTEELLKQRHEN 441
                   +    +N+    L  +S++  +   +I E   LK+ +  L +  E L+  HE 
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1168

Query: 442  IQQQLQTMEEKKGISGYSYTQ----------------------EELERVSALKSEVDEMK 479
               + +++  K G    ++                        E+LE++  ++ E   ++
Sbjct: 1169 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1228

Query: 480  GRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGL 539
             +  + ++   KKL           + ++KE   L+  ++ L    +  K +       L
Sbjct: 1229 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE----QTRL 1284

Query: 540  ESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISS-----DQQ 594
            E+  SKL+++ ++L     +  ++    + +  NLE + R   D+++  +       +Q 
Sbjct: 1285 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1344

Query: 595  EKRKAI----REQYTKNTAEQENLGKKLREK---QKVIRESHGPNMKQAKMWRDLEQLME 647
             + K +    + QY     E     +KL EK   Q    +   P  +   +   + +L++
Sbjct: 1345 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIK 1404

Query: 648  CKKQCFLKQQSQTSIGQVIQEGGEDRLIL 676
             KK    ++Q   ++     +  E  L L
Sbjct: 1405 SKKDINRERQKSLTLTPTRSDSSEGFLQL 1433



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 61/296 (20%), Positives = 123/296 (41%), Gaps = 33/296 (11%)

Query: 316 INEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRK-KEAKAEELQEAKEKLASLER 374
           +N++  +IN  +E + + N+ +    SL     SI+ R+ K    E LQ+    + SL  
Sbjct: 48  LNQVMLQINPKLESQRV-NKKVNNDASLRMHNLSILVRQIKFYYQETLQQLI--MMSLPN 104

Query: 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEEL 434
              + +N   E  GTE     E K+ +  L   +   +KK + I  ++   GL   T+  
Sbjct: 105 VLIIGKNPFSE-QGTE-----EVKKLLLLLLGCAVQCQKKEEFIERIQ---GLDFDTKAA 155

Query: 435 LKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLY 494
           +    + +    + + + + +     +QE++E +  LK+    +K R +D+  E  + + 
Sbjct: 156 VAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPL--LKNMALHLK-RLIDERDEHSETII 212

Query: 495 SLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLR 554
            L  E+          L  L          C     +       L    +  + ++RRLR
Sbjct: 213 ELSEERDG--------LHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLR 264

Query: 555 EECLQEESRYHYTNCM--IKNLEVQLRRATDEMKAYISSDQ-----QEKRKAIREQ 603
           +E   EE      +C   ++ +E++L+R   E    +S  +     +++  A+RE+
Sbjct: 265 QEL--EEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 115/550 (20%), Positives = 254/550 (46%), Gaps = 65/550 (11%)

Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAE 170
           ELK++   A+FL+  +V +  LQ+E      +Q EEL E  K + K+ E++         
Sbjct: 212 ELKRKLERAKFLLP-QVQTNTLQEEMW----RQEEELREQEKKIRKQEEKM---WRQEER 263

Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVE----KEREEYLAQQK 226
           +R+    M E+++++ ++ + L+++ +  +  +  L+  ++LR +    +E+EE + +Q+
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323

Query: 227 Q---EQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283
           +   EQ+ +++   +RL   + Q++   Q   D   E  M   +E ++     + E+   
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRD--QEERMWEQDERLREKEERMREQEKM 381

Query: 284 -ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLS 342
            E E K +E   +++   +       + E E K+ +    + +  EK+  +    E K  
Sbjct: 382 WEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 441

Query: 343 LYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVN 402
           L+ Q+      K + + E++ E +EK+   E     ++   R+    E  + D+      
Sbjct: 442 LWEQE------KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE--QEDQMWEQEE 493

Query: 403 KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQ 462
           K+R +      + + + E       L+  EE ++++ +  QQ+ +  EEKK       TQ
Sbjct: 494 KMRDQEQKMWDQEERMWEQDER---LREKEERMREQKKMWQQEEKMREEKK-------TQ 543

Query: 463 EELERVSALKSEVDEMKGRTLDDMSEMVKKL---YSLVSEKKSALASVIKELRQLRQK-- 517
           E+ +     K+   E K R  + M E  KK+     ++ E++  +    +++R+  +K  
Sbjct: 544 EQEK-----KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMW 598

Query: 518 -YQELTQECDEKK-SQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLE 575
             +E  QE +EK   Q +      E ++ + ++E+   +EE +QE+    +        E
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQ------E 652

Query: 576 VQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQ 635
            ++R   ++M+     +Q+EK +   E+  +   + +   +K+RE+++ +R       ++
Sbjct: 653 EKMREQEEKMR-----EQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRG------QE 701

Query: 636 AKMWRDLEQL 645
            KMW   E++
Sbjct: 702 EKMWGQEEKM 711



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 96/525 (18%), Positives = 241/525 (45%), Gaps = 71/525 (13%)

Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE---REEYLAQQ 225
           AE+++ +   E EK ++   V+ LK+++E A+   ++L   +   +++E   +EE L +Q
Sbjct: 190 AELQEKLRLAESEKSEIQLNVKELKRKLERAK---FLLPQVQTNTLQEEMWRQEEELREQ 246

Query: 226 KQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKEL 285
           +++ + Q     ++ +R++ Q   MR+       E  M+R E+ ++        +  KEL
Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMREQ------EEKMRRQEKRLR--------EQEKEL 292

Query: 286 ENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYR 345
             ++KEL   +K+  +       + E E K+ E   ++ +  EK             ++R
Sbjct: 293 REQEKELREQKKLREQ----EEQMQEQEEKMWEQEEKMREQEEK-------------MWR 335

Query: 346 QQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLR 405
           Q+  +  ++K+ + +E +   ++    E++  ++  + R  +  ++ + +E  +   ++R
Sbjct: 336 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIR 395

Query: 406 SKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEEL 465
            +    +++ + + E + +   +Q+ EE + ++ E   QQ +  E+K+ +      QE+ 
Sbjct: 396 EREKKMREEEETMREQEEK---MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE 452

Query: 466 ERVSALKSEV---DEMKGRTL------------DDMSEMVKKLYSLVS----------EK 500
           E++   + ++   +EM G+              D M E  +K+               E+
Sbjct: 453 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512

Query: 501 KSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQE 560
              L    + +R+ ++ +Q+  +  +EKK+Q        +  + + E+ +R   ++  +E
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572

Query: 561 ESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLRE 620
           E         ++  E ++R   ++M       Q+++ K   ++      E+E+   K++E
Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED---KMQE 629

Query: 621 KQKVIRESHGPNMKQA-KMWRDLEQLMECKKQCFLKQQSQTSIGQ 664
           +++++ E      +Q  KMW   E++ E +++  +++Q +   GQ
Sbjct: 630 QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK--MREQEEKMQGQ 672



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 103/501 (20%), Positives = 208/501 (41%), Gaps = 99/501 (19%)

Query: 179 EEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQ---QKQEQKN---- 231
           E+EK    +  E L++ +E AQ+H   ++I    + E E   Y +Q   +K E  N    
Sbjct: 70  EDEKKASHQHQEALRREIE-AQDHT--IRILTCQKTELETALYYSQDAARKFEDGNLGES 126

Query: 232 --------QLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283
                     +H    LQR  + + +  + A D   E L K   + +   LY  T    +
Sbjct: 127 KDLAGRLHHSWHFAGELQRALSAVSTWHKKA-DRYIEELTKE-RDALSLELYRNTIT-NE 183

Query: 284 ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSL 343
           EL+ K  EL                L   ES+ +EI   + +L ++K+ R      K  L
Sbjct: 184 ELKKKNAELQ-------------EKLRLAESEKSEIQLNVKEL-KRKLER-----AKFLL 224

Query: 344 YRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK 403
            + Q + +  +   + EEL+E ++K+   E +   +  + RE +G    + ++ +R   +
Sbjct: 225 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKR 284

Query: 404 LRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQE 463
           LR +    +++ + + E K            L+++ E +Q+Q + M E++          
Sbjct: 285 LREQEKELREQEKELREQKK-----------LREQEEQMQEQEEKMWEQE---------- 323

Query: 464 ELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQ 523
                               + M E  +K++     ++  L    K++R+  QK +    
Sbjct: 324 --------------------EKMREQEEKMW----RQEERLWEQEKQMREQEQKMR---- 355

Query: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATD 583
             D+++  ++      E      EQE    +EE +QEE R       ++  E  +R   +
Sbjct: 356 --DQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEE 413

Query: 584 EMKAYISSDQQEKRKAIREQ----YTKNTAEQENL---GKKLREKQKVIRESHGPNMKQA 636
           +M+    +  +++ K  ++Q      +   EQE +    +K+ E+++ IR+      ++ 
Sbjct: 414 KMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK 473

Query: 637 KMWRDLEQLMECKKQCFLKQQ 657
           KMWR  E++ E + Q + +++
Sbjct: 474 KMWRQ-EKMREQEDQMWEQEE 493



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 59/247 (23%), Positives = 110/247 (44%), Gaps = 48/247 (19%)

Query: 426 GLLQRTEELLKQRHENIQQQLQTM-EEKKGISGYSY----TQEELERVSALKSEVDEMKG 480
           G LQR    +   H+   + ++ + +E+  +S   Y    T EEL++ +A          
Sbjct: 141 GELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNA---------- 190

Query: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540
                  E+ +KL  L   +KS +   +KEL++  ++ + L  +      Q +      E
Sbjct: 191 -------ELQEKL-RLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ--E 240

Query: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600
               + E+++R+  E+  ++E R       ++  E ++RR    ++        E+ K +
Sbjct: 241 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR--------EQEKEL 292

Query: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQ--------AKMWRDLEQLMECKKQC 652
           REQ  K   EQ    KKLRE+++ ++E      +Q         KMWR  E+L E +KQ 
Sbjct: 293 REQ-EKELREQ----KKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ- 346

Query: 653 FLKQQSQ 659
            +++Q Q
Sbjct: 347 -MREQEQ 352



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 46/192 (23%), Positives = 86/192 (44%), Gaps = 26/192 (13%)

Query: 485 DMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRS 544
           D++  +   +    E + AL++V    ++  +  +ELT+E D         A  LE  R+
Sbjct: 128 DLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERD---------ALSLELYRN 178

Query: 545 KLEQEVRRLREECLQE-----ESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE---- 595
            +  E  + +   LQE     ES        +K L+ +L RA   +    ++  QE    
Sbjct: 179 TITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWR 238

Query: 596 KRKAIREQYTKNTAEQENLGK---KLREKQKVIRESHGPNMKQAKMWRD-----LEQLME 647
           + + +REQ  K   ++E + +   +LRE++  +RE      +Q K  R+      EQ  E
Sbjct: 239 QEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE 298

Query: 648 CKKQCFLKQQSQ 659
            ++Q  L++Q +
Sbjct: 299 LREQKKLREQEE 310


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 115/506 (22%), Positives = 231/506 (45%), Gaps = 46/506 (9%)

Query: 180 EEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239
           +E+DQ  +R E   +++E     +      RQ R E+ERE  LA+ +++ + Q     + 
Sbjct: 115 QEEDQ--RRFEPRDRQLEEEPGQR-----RRQKRQEQERE--LAEGEEQSEKQERLEQRD 165

Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV 299
            QR   +L   RQ   + +     +  EE+++      TE+FP E + +++EL  L++  
Sbjct: 166 RQRRDEELWRQRQEWQEREER---RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222

Query: 300 SEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKA 359
            E         E + +  E    + Q  E+K  R        ++ R++   +  ++  + 
Sbjct: 223 RE---------EKQQQRRERQDRVFQEEEEKEWRKRE-----TVLRKEEEKLQEEEPQRQ 268

Query: 360 EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIA 419
            ELQE +E+L  LER+   +  Q  E     + +  + +R   + R +    +++ Q   
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERR 328

Query: 420 ELKAEFGLLQRTEELLKQRHENIQQQL-QTMEEKKGISGYSYTQEELERVSALKSEVDEM 478
           E + E    +R ++L +++ E  +QQL +  EE++        QEE  R   L+ E    
Sbjct: 329 EQQEE----RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384

Query: 479 KGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAG 538
           + + L    + +++   L  E++      ++  +QLR++ Q+L +E +E++ +       
Sbjct: 385 REQQL-RREQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRREQEEERHEQKHEQER 442

Query: 539 LESNRSKLEQEVRR---LREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE 595
            E  R K EQE RR    REE  +   +      + ++ E + R    +++     +QQE
Sbjct: 443 RE-QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501

Query: 596 KR--------KAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLME 647
           +R        +  REQ  K   E+E L ++LR +Q++ RE      +Q     + ++L +
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE-ERREQLLKREEEKRLEQ 560

Query: 648 CKKQCFLKQQSQTSIGQVIQEGGEDR 673
            +++  LK++ +    Q+++   E R
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERR 586



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 96/452 (21%), Positives = 216/452 (47%), Gaps = 45/452 (9%)

Query: 180 EEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239
           +E+++ ++++E  + R E  +  Q   ++ R+ ++ +++EE   +Q++E++ Q     Q+
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331

Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV 299
            +R + QL+  +    + + E  ++R +EE +    +  E   +E E ++++L   Q++ 
Sbjct: 332 EERREQQLRREQ----EERREQQLRREQEEERREQQLRRE---QEEERREQQLRREQQLR 384

Query: 300 SEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKA 359
            E  +     L  E ++           E+++ R + +  +  L R+Q  +   ++E + 
Sbjct: 385 REQQLRREQQLRREQQLRR---------EQQLRREQQLRREQQLRREQ-QLRREQEEERH 434

Query: 360 EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIA 419
           E+  E + +   L+RE   +R+  +  + TE  + ++ +R     R +    +++   + 
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETE--RHEQERRKQQLKRDQEEERRERWLKLE 492

Query: 420 ELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMK 479
           E +      +R ++L +++ E  +Q+L+  EE++ +     ++++L R    + E  ++ 
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE--QLL 550

Query: 480 GRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGL 539
            R  +   E  ++   L  E++     ++K   + RQ  Q L +E +E+  Q        
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ--QRLKREQEERLEQRLK----- 603

Query: 540 ESNRSKLEQEVR---RLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEK 596
                +LEQE R   RL+ E  +EE R      ++K+ E + RR     +  +  +QQE+
Sbjct: 604 REEVERLEQEERREQRLKREEPEEERRQQ----LLKSEEQEERR-----QQQLRREQQER 654

Query: 597 RKAIREQYTKNTAEQENLGKKL-REKQKVIRE 627
               REQ  K   E+E L ++L RE ++  RE
Sbjct: 655 ----REQRLKREEEEERLEQRLKREHEEERRE 682



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 108/543 (19%), Positives = 242/543 (44%), Gaps = 41/543 (7%)

Query: 126 EVPSEFLQDETVA--DTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183
           E   E+ + ETV   +  K  EE  +  + L +E EQL+       E+R++    EE++ 
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR--KLERQELRRERQE-EEQQQ 297

Query: 184 QLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRV 243
           Q ++R + L+++ E  +  Q   +  +Q R E++ E    Q ++EQ+ +    ++R Q  
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357

Query: 244 QNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELE-NKKKELHFLQKVVSEP 302
           + + + +R+   + + E  ++R ++  +       ++  +E +  ++++L   Q++  E 
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 417

Query: 303 AMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS----IISRKKEAK 358
            +     L  E +      +  Q   ++ ++ E  E +  L R++ +       RK++ K
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477

Query: 359 AEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQII 418
            ++ +E +E+   LE E   ++ + RE    + L+ ++ +R   +L+ +    + + ++ 
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERRE----QQLRREQEERREQRLKRQEEEERLQQRLR 533

Query: 419 AELKAEFGLLQRTEELLK----QRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474
           +E +      +R E+LLK    +R E  +++ +   E++        +EE  R   LK E
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE 593

Query: 475 VDE-----MKGRTLDDMSEMVKKLYSLVSE--KKSALASVIKELRQLRQKYQELTQECDE 527
            +E     +K   ++ + +  ++   L  E  ++     ++K   Q  ++ Q+L +E  E
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653

Query: 528 KKSQYDSCAAGLESNRSKLEQEVRRLREECLQE--------ESRYHYTNCMIKNLEVQLR 579
           ++ Q        E    +LEQ ++R  EE  +E        E         I   + QL 
Sbjct: 654 RREQ----RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLE 709

Query: 580 RATD--EMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAK 637
              D  + K Y    +QE ++  +EQ  K    +  L  + +E+++  R+      ++  
Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL--QWQEEERAHRQQQEEEQRRDF 767

Query: 638 MWR 640
            W+
Sbjct: 768 TWQ 770



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 136/600 (22%), Positives = 260/600 (43%), Gaps = 73/600 (12%)

Query: 107 QRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGF 166
           QR  EL++     R L + E+  E  ++E      +Q + L    +   K+ E+ +    
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEE------QQQQRLRREQQLRRKQEEERREQQE 319

Query: 167 STAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE---REEYLA 223
              E ++     EE ++Q ++R E  ++R +  +  Q   +  +QLR E+E   RE+ L 
Sbjct: 320 ERREQQERREQQEERREQQLRR-EQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378

Query: 224 QQKQEQKNQLFHAVQRLQRVQ-----NQLKSMRQAAAD--AKPESLMKRLEEEIKFNLYM 276
           +++Q ++ Q     Q+L+R Q      QL+  +Q   +   + E  ++R +EE +     
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438

Query: 277 VTEKFPKELENKKKELHFLQKVVSEPAMGHSD-----------------LLELES----- 314
             E+  + L+ +++E     K   E      +                  L+LE      
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498

Query: 315 ----KINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEEL--QEAKEK 368
               +  ++  E  +  E+++ R E  E +L    +    + R++E + E+L  +E +++
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEE-EERLQQRLRSEQQLRREQEERREQLLKREEEKR 557

Query: 369 LASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKK--KHQIIAELKAEFG 426
           L    RE  +KR Q    D  ++LK +E +R     R +    ++  K + +  L+ E  
Sbjct: 558 LEQERREQRLKREQEERRD--QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE-- 613

Query: 427 LLQRTEELLKQR--HENIQQQLQTMEEKKGISGYSYTQEELE-RVSALKSEVDEMK-GRT 482
             +R E+ LK+    E  +QQL   EE++        +E+ E R   LK E +E +  + 
Sbjct: 614 --ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671

Query: 483 LDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESN 542
           L    E  ++   L  E++      IK   ++ +   +L  E D ++S+  S     E  
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKS--RIPKWQWQLESEADARQSKVYSRPRKQEGQ 729

Query: 543 RSKLEQEVRRLREEC---LQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKA 599
           R + EQE +R R E     QEE R H      +  E Q R  T + +A      +EK + 
Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQ----QQEEEQRRDFTWQWQA------EEKSER 779

Query: 600 IREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659
            R++ +     +E   ++LR +++  RE      ++ K  R  ++    K+  FL+++ Q
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 106/534 (19%), Positives = 226/534 (42%), Gaps = 71/534 (13%)

Query: 122  LIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEE 181
            L + E   +F ++E      ++  + +E  + L +E  +         + R++   ++E 
Sbjct: 1423 LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR---------KFREEEQLLQER 1473

Query: 182  KDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQK----NQLFHAV 237
            ++Q + R E  +K +E  Q      ++ RQ R  K RE+ L  Q+ E+K     Q  H  
Sbjct: 1474 EEQQLHRQERDRKFLEEEQ------QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527

Query: 238  QRLQR-VQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQ 296
            QR ++ +Q + +  RQ     + +   ++  EE +       ++  ++  ++K  L   Q
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE-Q 1586

Query: 297  KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKE 356
            KV  +         E E K  E   ++ +   ++ +R E    +   +R+   ++  ++E
Sbjct: 1587 KVRRQ---------EQERKFMEDEQQLRRQEGQQQLRQE----RDRKFREDEQLLQEREE 1633

Query: 357  AKAEELQ------EAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTV 410
             +    +      E + +L   ERE  ++ ++ R+F   E L  +  ++ + + + +   
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR-QERDRK 1692

Query: 411  FKKKHQIIAELKAEFGLLQRTEELLKQ------------RHENIQQQLQTMEEKKGISGY 458
            F+++ Q +   + E   LQ  ++L +Q            R E  Q+QL+  E  + I   
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE 1752

Query: 459  SYTQEELERVSALKSEVDEMKGRTLDDMSEM--VKKLYSLVSEKKSALASVIKELRQLRQ 516
               + E E     + E D  K R  + + +    ++L S  S++K       +E  QLRQ
Sbjct: 1753 EQLRPEREEQQLRRQERDR-KFREEEQLRQEREEQQLRSQESDRK------FREEEQLRQ 1805

Query: 517  KYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEV 576
            + +E      ++  +Y       E  + +LE++ +RLR    QE  R +         E 
Sbjct: 1806 EREEQQLRPQQRDGKYR-----WEEEQLQLEEQEQRLR----QERDRQYRAEEQFATQEK 1856

Query: 577  QLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHG 630
              R   +  +      +QE+ + +RE++ +   ++E   +++ E +    + HG
Sbjct: 1857 SRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHG 1910



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 101/547 (18%), Positives = 238/547 (43%), Gaps = 53/547 (9%)

Query: 130  EFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRV 189
            +FL++E      ++ ++L E    L ++ E+ +     + E R+D     + +++  +R 
Sbjct: 832  QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR-----SQEQRRDQKWRWQLEEERKRRR 886

Query: 190  EHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249
              L  +    +  +   ++ ++   E +REE   +++QEQ+ Q +   ++LQ+ + QL  
Sbjct: 887  HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ-YREEEQLQQEEEQLLR 945

Query: 250  MRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309
              +     +      R +++++     +  + P++   +++E  + ++   E      + 
Sbjct: 946  EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE---EELQQEEEQ 1002

Query: 310  LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEE-LQEAKEK 368
            L  E +      E  +   KK    +  E  L   R++  +  R+++ + EE LQ+ +E+
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062

Query: 369  LASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL 428
            L   ERE   ++   R++   E L+ +E      +L  +    +++ +   + + E  L 
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEE-----EQLLREEPEKRRRQERERQCREEEELQ 1117

Query: 429  QRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSE 488
            Q  E+LL++  E  ++Q                  ELER    + EV + + + L +  E
Sbjct: 1118 QEEEQLLREEREKRRRQ------------------ELERQYREEEEVQQEEEQLLREEPE 1159

Query: 489  MVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQ 548
                       ++  L    +E  +L+Q+ ++L +E  EK+ Q +      E    + ++
Sbjct: 1160 ---------KRRRQELERQYREEEELQQEEEQLLREEQEKRRQ-ERERQYREEEELQRQK 1209

Query: 549  EVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNT 608
              +R R+E  + + ++ +        E +   A  + K Y    + E+ + + +   ++ 
Sbjct: 1210 RKQRYRDEDQRSDLKWQW--------EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261

Query: 609  AEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTS--IGQVI 666
              Q++L   L E+Q+  RE      +Q       E+ +E ++Q   K++ + S    Q++
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321

Query: 667  QEGGEDR 673
            +E  E++
Sbjct: 1322 REEREEK 1328



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 134/634 (21%), Positives = 264/634 (41%), Gaps = 101/634 (15%)

Query: 107  QRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNK--QYEELMEAFKTLHKEYEQLKIS 164
            +R   LK+     R  +K E  +E  + E      K  Q EE  E +  L +E E+ +  
Sbjct: 442  RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE-ERREQQ 500

Query: 165  GFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE-REEYLA 223
                 ++R++    EE ++Q +KR E  ++        Q  L+  +QLR E+E R E L 
Sbjct: 501  ERREQQLRRE---QEERREQRLKRQEEEERL-------QQRLRSEQQLRREQEERREQLL 550

Query: 224  QQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283
            ++++E++ +     QRL+R Q + +       + + +  +KR E+E +    +  E+  +
Sbjct: 551  KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR-EQEERLEQRLKREEVER 609

Query: 284  ELENKKKELHFLQKVVSEPAMGHSDLLELES----KINEINTEINQLIEKKMMRNEPIEG 339
              + +++E    ++   E       LL+ E     +  ++  E  +  E+++ R E  E 
Sbjct: 610  LEQEERREQRLKREEPEEER--RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667

Query: 340  KLSLYRQQASIISRKKEAKAEELQEAKEKLAS--------LEREASVKRNQT----REFD 387
                 +++     R++E   EE ++A+E++ S        LE EA  ++++     R+ +
Sbjct: 668  LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727

Query: 388  GTEVLKGDEFKRYVNKLRSKSTVFKKKH--------------QIIAELKAEFG------- 426
            G    +  E KR   +   +    ++ H              Q  AE K+E G       
Sbjct: 728  GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787

Query: 427  ---------------LLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEEL---ERV 468
                             QR +  L +  E  Q++ Q  E +K +  +   +E+L   ER 
Sbjct: 788  PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ-FLEEEEQLQRRERA 846

Query: 469  SALKSEVD----EMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKE--LRQLRQKYQELT 522
              L+ E D    + + R   +     K  + L  E+K    ++  +  L++  +K Q+L 
Sbjct: 847  QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906

Query: 523  QECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRAT 582
            QE +E+  + +         R + EQE +   EE LQ+E             E QL R  
Sbjct: 907  QEEEEELQREE------REKRRRQEQERQYREEEQLQQE-------------EEQLLREE 947

Query: 583  DEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMW--- 639
             E +     ++Q ++    +Q  +    +E   ++ +E++K  RE      ++ ++    
Sbjct: 948  REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007

Query: 640  RDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDR 673
            R+  +  E ++Q   K + Q    Q+++E  E R
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 119/542 (21%), Positives = 244/542 (45%), Gaps = 63/542 (11%)

Query: 142  KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201
            ++ E+  E  K+   ++ Q ++   + A   K  S   +++ Q  +R E  +KR      
Sbjct: 688  EEQEQARERIKSRIPKW-QWQLESEADARQSKVYSRPRKQEGQR-RRQEQEEKRRRRESE 745

Query: 202  HQWML--KIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQ-RVQNQLKSMRQAAADAK 258
             QW    +  RQ + E++R ++  Q + E+K++     QRL  R   + +  RQ  A+ +
Sbjct: 746  LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE--RGRQRLSARPPLREQRERQLRAEER 803

Query: 259  PESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINE 318
             +   + L EE +       E+  ++   ++KEL FL++         +  L+ E    +
Sbjct: 804  QQREQRFLPEEEE------KEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857

Query: 319  INTEIN-------------QLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEA 365
             + E               QL E++  R   +  K +L  Q      RK++   + LQE 
Sbjct: 858  EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ-----LRKEQ---QLLQEE 909

Query: 366  KEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425
            +E+L   ERE   ++ Q R++   E L+ +E ++ + + R K    +++ Q   + K   
Sbjct: 910  EEELQREEREKRRRQEQERQYREEEQLQQEE-EQLLREEREKRRRQERERQYRKDKK--- 965

Query: 426  GLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD 485
             L Q+ E+LL +  E  ++Q     EKK      Y +EE  +    +   +E + R   +
Sbjct: 966  -LQQKEEQLLGEEPEKRRRQ---EREKK------YREEEELQQEEEQLLREEREKRRRQE 1015

Query: 486  MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE---SN 542
                 +K   L  E++  L    +E R+L+++ ++  +E  E+  Q +    G E     
Sbjct: 1016 WERQYRKKDELQQEEEQLLREE-REKRRLQERERQYREE--EELQQEEEQLLGEERETRR 1072

Query: 543  RSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ---QEKRKA 599
            R +LE++ R+  EE  QEE +        +  + + R+  +E +     +Q   +E+ K 
Sbjct: 1073 RQELERQYRK-EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131

Query: 600  IREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQ--AKMWRDLEQLMECKKQCFLKQQ 657
             R++  +   E+E +    +E+++++RE      +Q   + +R+ E+L + ++Q   ++Q
Sbjct: 1132 RRQELERQYREEEEV---QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188

Query: 658  SQ 659
             +
Sbjct: 1189 EK 1190



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 112/530 (21%), Positives = 220/530 (41%), Gaps = 81/530 (15%)

Query: 130  EFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRV 189
            E L+ E   +  ++  +  E  + L +E E+ +    +  + R++   ++E ++Q ++R 
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356

Query: 190  EHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249
            E  +K  E    HQ       Q R   E E+ L +Q++E+K        R Q  + QL+ 
Sbjct: 1357 ERDRKFREEELRHQ------EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410

Query: 250  MRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309
             R      + E  + R E + KF       +  +++  +++E  FL++        H   
Sbjct: 1411 DRDRKF-REEEQQLSRQERDRKFR------EEEQQVRRQERERKFLEEEQQLRQERHRKF 1463

Query: 310  LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKL 369
             E E  + E      Q + ++    + +E +  L RQ+     R ++ + +EL+  + + 
Sbjct: 1464 REEEQLLQERE---EQQLHRQERDRKFLEEEQQLRRQE-----RDRKFREQELRSQEPER 1515

Query: 370  ASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQ 429
              LE E  + R Q +           +F +   +LR +    ++  Q   +   +F    
Sbjct: 1516 KFLEEEQQLHRQQRQR----------KFLQEEQQLRRQ----ERGQQRRQDRDRKF---- 1557

Query: 430  RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEM 489
            R EE L+Q  E  Q   Q  + K  +      ++E ER    K   DE + R  +   ++
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER----KFMEDEQQLRRQEGQQQL 1613

Query: 490  VKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQE 549
             ++      E +        +L Q R++ Q   QE D K  + +      +  R + EQ+
Sbjct: 1614 RQERDRKFREDE--------QLLQEREEQQLHRQERDRKFLEEEP-----QLRRQEREQQ 1660

Query: 550  VRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTA 609
            +R  R+   +EE +      + +  E QLRR             QE+ +  RE       
Sbjct: 1661 LRHDRDRKFREEEQL-----LQEGEEQQLRR-------------QERDRKFRE------- 1695

Query: 610  EQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659
            E++ L ++ RE++ +  E      +  + +R+ EQL +  +Q  L++Q +
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER 1745



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 122/604 (20%), Positives = 256/604 (42%), Gaps = 91/604 (15%)

Query: 107  QRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGF 166
            +R  + ++R Y     ++ E   + L++E      ++ E      K L ++ EQL +   
Sbjct: 920  KRRRQEQERQYREEEQLQQE-EEQLLREEREKRRRQERERQYRKDKKLQQKEEQL-LGEE 977

Query: 167  STAEIRKDISAMEEEKDQLIKRVEHL-KKRVETAQNHQWMLKIARQLRVEKEREEYLAQQ 225
                 R++      E+++L +  E L ++  E  +  +W  +  ++  +++E E+ L ++
Sbjct: 978  PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037

Query: 226  KQ----EQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKF 281
            ++    +++ + +   + LQ+ + QL    +     +      R EEE++     +  + 
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097

Query: 282  PKELENKKKELHFLQKVVSEPAMGHSDLL----------ELESKINEINTEINQLIEKKM 331
            P++   +++E    ++   E       LL          ELE +  E   E  Q  E+++
Sbjct: 1098 PEKRRRQERERQCREE--EELQQEEEQLLREEREKRRRQELERQYRE--EEEVQQEEEQL 1153

Query: 332  MRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEV 391
            +R EP + +    RQ+      ++  + EELQ+ +E+L   E+E   KR Q RE    + 
Sbjct: 1154 LREEPEKRR----RQELE----RQYREEEELQQEEEQLLREEQE---KRRQERE---RQY 1199

Query: 392  LKGDEFKRYVNKLRSKSTVFK---------KKHQIIAELKA--------EFGLLQRTEEL 434
             + +E +R   K R +    +         +K   + + K         +F  L+ ++  
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259

Query: 435  LKQRHENIQQQLQTMEEK---------KGISGYSYTQEELERVSALKSEVDEMKGRTLDD 485
             +Q  +++Q  L   +E+         +    +   +E+LER      E  E K R  D 
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLER-----EEQKEAKRR--DR 1312

Query: 486  MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELT------QECDEKKSQYDSCAAGL 539
             S+  K+L     E+K       ++ R+  Q  QE        QE D K  + +      
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEE--LRHQ 1370

Query: 540  ESNRSKLEQEVRRLREE----CLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE 595
            E  R  LE+E R  R+E     L+EE +        +  E QLR+  D         ++E
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLR-----CQEREQQLRQDRDR------KFREE 1419

Query: 596  KRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLK 655
            +++  R++  +   E+E   ++   ++K + E      ++ + +R+ EQL++ +++  L 
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479

Query: 656  QQSQ 659
            +Q +
Sbjct: 1480 RQER 1483



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 106/526 (20%), Positives = 224/526 (42%), Gaps = 77/526 (14%)

Query: 180  EEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239
            +E++Q +++    K R E  Q       ++RQ R  K REE    ++QE++ +     Q+
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQ-------LSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454

Query: 240  L----------------QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFP- 282
            L                +R + QL    +     + E  ++R E + KF    +  + P 
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE 1514

Query: 283  -------KELENKKKELHFLQ--KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMR 333
                   ++L  ++++  FLQ  + +     G     + + K  E   ++ Q  E++ + 
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE-EEQLRQEREEQQLS 1573

Query: 334  NEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLK 393
             +  + K  L  Q+      +++ +  +  E +++L   E +  +++ + R+F   E L 
Sbjct: 1574 RQERDRKFRLEEQKV-----RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL 1628

Query: 394  GDEFKRYVNK-------------LRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHE 440
             +  ++ +++             LR +    + +H    + + E  LLQ  EE   +R E
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQE 1688

Query: 441  ------NIQQQLQTMEEKKGI--SGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKK 492
                    +QQL+  E ++          ++ELER      E ++++  T  +     ++
Sbjct: 1689 RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF---REEEQLRQETEQEQLRRQER 1745

Query: 493  LYSLVSEKKSALASVIKELRQLR--QKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEV 550
               ++ E++       ++LR+    +K++E  Q   E++ Q        ES+R   E+E 
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ---LRSQESDRKFREEE- 1801

Query: 551  RRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQ---EKRKAIREQYTKN 607
             +LR+E  +++ R    +   +  E QL+    E +     D+Q   E++ A +E+  + 
Sbjct: 1802 -QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE 1860

Query: 608  TAE--QENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQ 651
              E  QE   K+ +E+++ +RE H    +Q K  +   Q+ E K Q
Sbjct: 1861 EQELWQEEEQKRRQERERKLREEH--IRRQQKEEQRHRQVGEIKSQ 1904



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 84/381 (22%), Positives = 162/381 (42%), Gaps = 41/381 (10%)

Query: 148  MEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLK 207
            +E  K   +E E+  +        ++    + +E+D+  +  E L +  E  Q H     
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH----- 1637

Query: 208  IARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQL------KSMRQAAADAK--- 258
              RQ R  K  EE    ++QE++ QL H   R  R + QL      + +R+   D K   
Sbjct: 1638 --RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695

Query: 259  PESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLE--LESKI 316
             E  ++R E E KF L    +   +ELE K +E   L++   +  +   +     LE + 
Sbjct: 1696 EEQQLRRQERERKF-LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754

Query: 317  NEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREA 376
                 E  QL  ++  R    E +L   R++  + S++ + K  E ++ ++     ERE 
Sbjct: 1755 LRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ-----EREE 1809

Query: 377  SVKRNQTREFDG-----TEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRT 431
               R Q R  DG      E L+ +E ++ + + R +   ++ + Q   + K+     +  
Sbjct: 1810 QQLRPQQR--DGKYRWEEEQLQLEEQEQRLRQERDRQ--YRAEEQFATQEKSR----REE 1861

Query: 432  EELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVK 491
            +EL ++  +  +Q+ +    ++ I      ++   +V  +KS+  +  GR L+  +    
Sbjct: 1862 QELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQ-- 1919

Query: 492  KLYSLVSEKKSALASVIKELR 512
              ++ V  + S L   I+E R
Sbjct: 1920 --FASVPVRSSPLYEYIQEQR 1938



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 69/329 (20%), Positives = 133/329 (40%), Gaps = 81/329 (24%)

Query: 349 SIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS 408
           S++  +++ + +   E +++   LE E   +R Q R+    E+ +G+E      +L  + 
Sbjct: 108 SLLQDRRQEEDQRRFEPRDR--QLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165

Query: 409 TVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERV 468
                               +R EEL +QR     Q+ Q  EE++         EE +  
Sbjct: 166 RQ------------------RRDEELWRQR-----QEWQEREERRA--------EEEQLQ 194

Query: 469 SALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEK 528
           S    E +E          E +++                +EL +LR+K +E  Q+  ++
Sbjct: 195 SCKGHETEEFPDE------EQLRR----------------RELLELRRKGREEKQQ--QR 230

Query: 529 KSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAY 588
           + + D      E    +  + V R  EE LQEE             E Q +R   E    
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE-------------EPQRQRELQE---- 273

Query: 589 ISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRD----LEQ 644
              ++++ RK  R++  +   E+E   ++LR +Q++ R+      +Q +  R+     EQ
Sbjct: 274 ---EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330

Query: 645 LMECKKQCFLKQQSQTSIGQVIQEGGEDR 673
             E ++Q   ++Q +    Q+ +E  E+R
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEER 359


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 116/563 (20%), Positives = 259/563 (46%), Gaps = 63/563 (11%)

Query: 133  QDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHL 192
            ++E  ++   +   L +   +L ++ + L+++     ++ K+  A E +   L + +  L
Sbjct: 933  EEEMNSELVAKKRNLEDKCSSLKRDIDDLELT---LTKVEKEKHATENKVKNLSEEMTAL 989

Query: 193  KKRVETAQNHQWMLKIARQ-----LRVEKEREEYLAQ---QKQEQKNQLFHAVQRLQRVQ 244
            ++ +      +  L+ A Q     L+VE+++   L +   + ++Q + L  ++++ ++++
Sbjct: 990  EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLR 1049

Query: 245  NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304
              L+  ++     K E  +K  +E I  +L    ++  ++L+ K+ EL  LQ  + +  +
Sbjct: 1050 ADLERAKR-----KLEGDLKMSQESI-MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103

Query: 305  GHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQE 364
             HS  L+ + KI E+   I +L        E IE + +L  +    I +++   A EL+E
Sbjct: 1104 -HS--LQFQKKIKELQARIEEL-------EEEIEAEHTLRAK----IEKQRSDLARELEE 1149

Query: 365  AKEKL--ASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELK 422
              E+L  AS    A ++ N+ RE +  + ++ D  +  +    + +T+ KK+   +AEL 
Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAE-FQKMRRDLEEATLQHEATAATLRKKQADSVAELG 1208

Query: 423  AEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERV--------SALKSE 474
             +   LQR ++ L++    ++ ++  M     I   S ++  +ER         S +K++
Sbjct: 1209 EQIDNLQRVKQKLEKEKSELKMEIDDMASN--IEALSKSKSNIERTCRTVEDQFSEIKAK 1266

Query: 475  VDEMKGRTLDDMSEMVKKLYSL-------VSEKKSALASVIKELRQLRQKYQELTQECDE 527
             DE + + + D++    +L +        V EK+S ++ + K  + L Q+ +EL ++ +E
Sbjct: 1267 -DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEE 1325

Query: 528  KKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIK-NLEVQLRRATDEMK 586
            +    ++ A  L+S+R   +    +  EE   +E++      + K N EV   R   E  
Sbjct: 1326 ETKAKNAMAHALQSSRHDCDLLREQYEEE---QEAKAELQRALSKANSEVAQWRTKYETD 1382

Query: 587  AYISSDQ-QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645
            A   +++ +E +K + ++  +     E    K    +K  +   G   +   + RDLE+ 
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQG---EVEDLMRDLER- 1438

Query: 646  MECKKQCFLKQQSQTSIGQVIQE 668
                  C    + Q +  +V+ E
Sbjct: 1439 --SHTACATLDKKQRNFDKVLAE 1459



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 108/535 (20%), Positives = 229/535 (42%), Gaps = 67/535 (12%)

Query: 168  TAEIRKDISAMEEEKDQL---IKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQ 224
            +AE  K+++ M+E+ ++    + R E  +K +E         K   QL+V+ E E  +  
Sbjct: 846  SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905

Query: 225  QKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKE 284
            +               +R +  +KS  +   +AK + L +RLEEE + N  +V +K  + 
Sbjct: 906  E---------------ERCEGLIKS--KILLEAKVKELTERLEEEEEMNSELVAKK--RN 946

Query: 285  LENK----KKELHFLQ----KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEP 336
            LE+K    K+++  L+    KV  E     + +  L  ++  +   I++L ++K    E 
Sbjct: 947  LEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEA 1006

Query: 337  IEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVK---RNQTREFDGTEVLK 393
             +  L   + +   ++   +  A+  Q+  +   SLE+E  ++       R+ +G   + 
Sbjct: 1007 HQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMS 1066

Query: 394  GDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKK 453
             +      N  +      KKK   +++L+A+    Q      +++ + +Q +++ +E   
Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE--- 1123

Query: 454  GISGYSYTQEELERVSALKSEVDEMK---GRTLDDMSEMVKKLYSLVSEKKSALASVIKE 510
                     EE+E    L++++++ +    R L+++SE +++     S +         E
Sbjct: 1124 ---------EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAE 1174

Query: 511  LRQLRQKYQELTQECDE-----KKSQYDSCAA------GLESNRSKLEQEVRRLREECLQ 559
             +++R+  +E T + +      +K Q DS A        L+  + KLE+E   L+ E   
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDD 1234

Query: 560  EESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKR--KAIREQYTKNTAEQENLGKK 617
              S     +    N+E   R   D+     + D+Q+ +    +  Q  +   +   L  +
Sbjct: 1235 MASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHR 1294

Query: 618  LREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGED 672
            + EK+ +I  S     KQA      +QL E K+Q   + +++ ++   +Q    D
Sbjct: 1295 VEEKESLI--SQLTKSKQAL----TQQLEELKRQMEEETKAKNAMAHALQSSRHD 1343



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 110/478 (23%), Positives = 213/478 (44%), Gaps = 88/478 (18%)

Query: 144  YEELMEAFKTLHKEY-----------EQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHL 192
            YEE+++  +TL +E            EQ+  +G +  E  K    +E+EK  L   +E +
Sbjct: 1492 YEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEV 1551

Query: 193  KKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ 252
            +  +E  +        ++ LRV+ E    L+Q K E   ++    + ++    QLK   Q
Sbjct: 1552 EGSLEHEE--------SKILRVQLE----LSQVKSELDRKVIEKDEEIE----QLKRNSQ 1595

Query: 253  AAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLEL 312
             AA    E+L   L+ EI+     +  +  K++E    E+        E  +GHS+    
Sbjct: 1596 RAA----EALQSVLDAEIRSRNDAL--RLKKKMEGDLNEM--------EIQLGHSNRQMA 1641

Query: 313  ESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASL 372
            E++   + T   QL + ++  ++ +     L ++Q +I+ R+     EEL+E K  L   
Sbjct: 1642 ETQ-KHLRTVQGQLKDSQLHLDDALRSNEDL-KEQLAIVERRNGLLLEELEEMKVALEQT 1699

Query: 373  EREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQI-IAELKAEFGLLQRT 431
            ER        TR     E+L   +  + ++   +     KKK +  IA+ +AE       
Sbjct: 1700 ER--------TRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEV------ 1745

Query: 432  EELLKQRHENIQQQLQTMEE--KKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEM 489
                    EN  Q+ +  EE  KK I+  +   EEL++     + ++ MK     ++ + 
Sbjct: 1746 --------ENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK----KNLEQT 1793

Query: 490  VKKLYSLVSE-KKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQ 548
            VK L   + E ++ AL    K++++L  + +EL  E D ++ +      G E+ +   + 
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKR------GAEALKGAHKY 1847

Query: 549  EVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTK 606
            E R+++E   Q E  +       KN+ ++L+   D+++A + S +++  +A  +  T+
Sbjct: 1848 E-RKVKEMTYQAEEDH-------KNI-LRLQDLVDKLQAKVKSYKRQAEEAEEQANTQ 1896



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 68/285 (23%), Positives = 122/285 (42%), Gaps = 55/285 (19%)

Query: 396  EFKRYVNKLRSKSTVFKKKHQIIAELKAE----FGLLQRTEELLKQRHENIQQQLQTMEE 451
            EFK+ + +   + ++F  ++ I + +  +      L  + + LLK      ++++ TM+E
Sbjct: 804  EFKKMMER---RDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEA--EKEMATMKE 858

Query: 452  KKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKEL 511
                  +  T+EEL R  A + E++E              K+ SL+ EK      V  E 
Sbjct: 859  D-----FERTKEELARSEARRKELEE--------------KMVSLLQEKNDLQLQVQSET 899

Query: 512  RQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMI 571
              L     +  + C+           GL  ++  LE +V+ L E   +EE          
Sbjct: 900  ENL----MDAEERCE-----------GLIKSKILLEAKVKELTERLEEEEEMNSELVAKK 944

Query: 572  KNLE---VQLRRATDEMKAYISSDQQEKRKAIREQYTKN-----TAEQENLGKKLREKQK 623
            +NLE     L+R  D+++  ++  + EK K   E   KN     TA +EN+ K  +EK K
Sbjct: 945  RNLEDKCSSLKRDIDDLE--LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK-K 1001

Query: 624  VIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQE 668
             ++E+H   +   ++  D    +  K    L+QQ+    G + QE
Sbjct: 1002 SLQEAHQQTLDDLQVEEDKVNGL-IKINAKLEQQTDDLEGSLEQE 1045



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 66/337 (19%), Positives = 140/337 (41%), Gaps = 55/337 (16%)

Query: 111  ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYE--QLKISGF-- 166
            E++ R    R   K+E     ++ + +  +N+Q  E  +  +T+  + +  QL +     
Sbjct: 1608 EIRSRNDALRLKKKMEGDLNEMEIQ-LGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666

Query: 167  STAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQ-----NHQWMLKIARQLRV------- 214
            S  ++++ ++ +E     L++ +E +K  +E  +     + Q +L  + ++++       
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726

Query: 215  ----EKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPES--------L 262
                +K+ E  +AQ + E +N +  +    ++ +  +      A + K E         +
Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786

Query: 263  MKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSE-----------PAMGHSDLLE 311
             K LE+ +K   + + E     L+  KK++  L+  V E            A       +
Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHK 1846

Query: 312  LESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLAS 371
             E K+ E+  +  +   K ++R + +  KL     QA + S K++  AEE +E      S
Sbjct: 1847 YERKVKEMTYQAEE-DHKNILRLQDLVDKL-----QAKVKSYKRQ--AEEAEEQANTQLS 1898

Query: 372  LEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS 408
              R    +  +  E       + D  +  VNKLR+KS
Sbjct: 1899 RCRRVQHELEEAAE-------RADIAESQVNKLRAKS 1928



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 27/114 (23%), Positives = 52/114 (45%), Gaps = 16/114 (14%)

Query: 149  EAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI 208
            EA K  HK   ++K   +   E  K+I  +++  D+L  +V+  K++ E A+  Q   ++
Sbjct: 1839 EALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAE-EQANTQL 1897

Query: 209  ARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESL 262
            +R  RV+ E EE               A +R    ++Q+  +R  + D   + +
Sbjct: 1898 SRCRRVQHELEE---------------AAERADIAESQVNKLRAKSRDVGSQKM 1936


>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
           b [Homo sapiens]
          Length = 882

 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 118/611 (19%), Positives = 261/611 (42%), Gaps = 84/611 (13%)

Query: 106 LQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISG 165
           L+  +E K+   + + ++KLE+    L++ET A   ++ +++      L    ++L++  
Sbjct: 191 LEAVSEQKRN--IMKDMMKLELDLHGLREETSAHIERKDKDIT----ILQCRLQELQLEF 244

Query: 166 FSTAEIRKDISAMEEEKDQ---------------LIKRVEHLKKRVETAQNHQWMLKIAR 210
             T ++        +EKD+               L+K+ + L+K+   A   +  +K A+
Sbjct: 245 TETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK 304

Query: 211 QLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADA--KPESLMKRLEE 268
           Q + ++   + L  + Q+ KN L  A Q+ +    Q    ++ AA A    E   ++L++
Sbjct: 305 QDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK 364

Query: 269 EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLI- 327
            +     ++ ++    ++  ++EL  LQK   E +M   +      ++ E++ E+++ + 
Sbjct: 365 GL-----LLDKQKADTIQELQRELQMLQK---ESSMAEKEQTSNRKRVEELSLELSEALR 416

Query: 328 -----------------EKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLA 370
                            E+ M  N+ ++     +R+Q SI    K    E+LQEA + L 
Sbjct: 417 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI----KCKLEEDLQEATKLLE 472

Query: 371 SLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQR 430
               +    +   +  +G       EFK+    L+  S   +++++    L+AE      
Sbjct: 473 DKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE---NLRAELQCCST 529

Query: 431 TEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMV 490
             E    ++   QQ +Q + ++  +   S    + +   AL+ E   ++       + + 
Sbjct: 530 QLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQ-------TTIT 582

Query: 491 KKLYSLVSEKKSA----LASVIKELRQLRQKYQELTQ---ECDEKKSQYDSCAAGLESNR 543
           K+ Y  +S K +A    L   +++L  +  + + L Q   +  EKK+Q +      E   
Sbjct: 583 KEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERM 642

Query: 544 SKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQL----RRATDEMKAYISSDQQEKRKA 599
            KL  E+R+LR    + E   H  +  ++ +  Q+    ++  +++K   + ++Q     
Sbjct: 643 KKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQ----- 697

Query: 600 IREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQ-- 657
           +RE   +  A +ENL +   +K+              +++R  +Q+M   +Q + KQQ  
Sbjct: 698 LREFQEEMAALKENLLED--DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQ-WAKQQKV 754

Query: 658 SQTSIGQVIQE 668
           +   +G  ++E
Sbjct: 755 ANEKLGNQLRE 765



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 102/472 (21%), Positives = 207/472 (43%), Gaps = 70/472 (14%)

Query: 215 EKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNL 274
           E E  + + +  QEQK+     V+  Q +   L+   +A ++ K  ++MK + + ++ +L
Sbjct: 155 ECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQK-RNIMKDMMK-LELDL 212

Query: 275 YMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLEL---ESKINEINTEINQLIEKKM 331
           + + E+    +E K K++  LQ  + E  +  ++  +L   + K  +   E+ Q +EKK+
Sbjct: 213 HGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKL 272

Query: 332 --MRNEPIEGKLSLYRQQASIISRK---KEAKAE------------ELQEAKEKLASLER 374
             ++N  ++ +  L +QQ      +   KEAK +            E+Q+ K  L   ++
Sbjct: 273 TQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQ 332

Query: 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQ----- 429
           +  +   Q  +      L G   +    KL+    + K+K   I EL+ E  +LQ     
Sbjct: 333 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSM 392

Query: 430 ----------RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQ-----EELERVSALKSE 474
                     R EEL  +  E +++   + +EK+ +      Q     + L+R+     E
Sbjct: 393 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 452

Query: 475 VDEMKGRTLDDMSEMVKKL------YSLVSEKKSALASVIKELRQ--------LRQKYQE 520
              +K +  +D+ E  K L           E +  +   ++ LRQ        L++  ++
Sbjct: 453 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 512

Query: 521 LTQECDEKKSQYDSCAAGLESNRSKL---EQEVRRLREE-CLQEESRYHYTNCMIKNLEV 576
           L +E +  +++   C+  LES+ +K    +Q ++ L +E  LQ+ES        + +L+ 
Sbjct: 513 LEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKES--------LMSLQA 564

Query: 577 QLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRES 628
           QL +A  + K Y+ +     ++A      K+ A Q++L + L +   V  E+
Sbjct: 565 QLDKALQKEKHYLQT--TITKEAYDALSRKSAACQDDLTQALEKLNHVTSET 614



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 105/560 (18%), Positives = 227/560 (40%), Gaps = 60/560 (10%)

Query: 154 LHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNH------QWMLK 207
           LH   EQL ++G   A + + ++   ++    +  +E L+ +V+  Q        Q    
Sbjct: 12  LHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPEN 71

Query: 208 IARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKR-- 265
                +V       + Q+ QE + +L    Q++ +  + ++ +R   A +    L +   
Sbjct: 72  KGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKA 131

Query: 266 -LEEEIKFNLYMVTEKFP----KELENKKKELHFLQ------------------------ 296
            ++ +  F     T ++P    +E E+ KK L  LQ                        
Sbjct: 132 LIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVEL 191

Query: 297 KVVSEPAMG-HSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355
           + VSE       D+++LE  ++ +  E +  IE+K      ++ +L   + + +   +  
Sbjct: 192 EAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLT 251

Query: 356 EAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKH 415
             K + LQE  E L  LE++ +  +N   + +  E+ K       +     ++   K K 
Sbjct: 252 LKKDKFLQEKDEMLQELEKKLTQVQNSLLKKE-KELEKQQCMATELEMTVKEAKQDKSKE 310

Query: 416 QIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISG--YSYTQEELERVSALKS 473
                L+AE   L+ + E  KQ+     QQ    +E+  ++G     TQ +L++   L  
Sbjct: 311 AECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL-- 368

Query: 474 EVDEMKGRTLDDMS---EMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS 530
             D+ K  T+ ++    +M++K  S+  +++++    ++EL     +     +  D++K 
Sbjct: 369 --DKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKR 426

Query: 531 QYDSCAAGLESNRSKLEQEVRRLREE-----CLQEESRYHYTNCMIKNLEVQLRRATDEM 585
           Q     A  +   + +   ++    E     C  EE     T  ++++   QL+++ +  
Sbjct: 427 QLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATK-LLEDKREQLKKSKEHE 485

Query: 586 KAY------ISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMW 639
           K        +  + ++K K ++E   K   E ENL  +L+     +  S        ++ 
Sbjct: 486 KLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVI 545

Query: 640 RDLEQLMECKKQCFLKQQSQ 659
           +DL + +  +K+  +  Q+Q
Sbjct: 546 QDLNKEIALQKESLMSLQAQ 565


>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
           a [Homo sapiens]
          Length = 1007

 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 118/611 (19%), Positives = 261/611 (42%), Gaps = 84/611 (13%)

Query: 106 LQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISG 165
           L+  +E K+   + + ++KLE+    L++ET A   ++ +++      L    ++L++  
Sbjct: 336 LEAVSEQKRN--IMKDMMKLELDLHGLREETSAHIERKDKDIT----ILQCRLQELQLEF 389

Query: 166 FSTAEIRKDISAMEEEKDQ---------------LIKRVEHLKKRVETAQNHQWMLKIAR 210
             T ++        +EKD+               L+K+ + L+K+   A   +  +K A+
Sbjct: 390 TETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK 449

Query: 211 QLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADA--KPESLMKRLEE 268
           Q + ++   + L  + Q+ KN L  A Q+ +    Q    ++ AA A    E   ++L++
Sbjct: 450 QDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK 509

Query: 269 EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLI- 327
            +     ++ ++    ++  ++EL  LQK   E +M   +      ++ E++ E+++ + 
Sbjct: 510 GL-----LLDKQKADTIQELQRELQMLQK---ESSMAEKEQTSNRKRVEELSLELSEALR 561

Query: 328 -----------------EKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLA 370
                            E+ M  N+ ++     +R+Q SI    K    E+LQEA + L 
Sbjct: 562 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI----KCKLEEDLQEATKLLE 617

Query: 371 SLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQR 430
               +    +   +  +G       EFK+    L+  S   +++++    L+AE      
Sbjct: 618 DKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE---NLRAELQCCST 674

Query: 431 TEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMV 490
             E    ++   QQ +Q + ++  +   S    + +   AL+ E   ++       + + 
Sbjct: 675 QLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQ-------TTIT 727

Query: 491 KKLYSLVSEKKSA----LASVIKELRQLRQKYQELTQ---ECDEKKSQYDSCAAGLESNR 543
           K+ Y  +S K +A    L   +++L  +  + + L Q   +  EKK+Q +      E   
Sbjct: 728 KEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERM 787

Query: 544 SKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQL----RRATDEMKAYISSDQQEKRKA 599
            KL  E+R+LR    + E   H  +  ++ +  Q+    ++  +++K   + ++Q     
Sbjct: 788 KKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQ----- 842

Query: 600 IREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQ-- 657
           +RE   +  A +ENL +   +K+              +++R  +Q+M   +Q + KQQ  
Sbjct: 843 LREFQEEMAALKENLLED--DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQ-WAKQQKV 899

Query: 658 SQTSIGQVIQE 668
           +   +G  ++E
Sbjct: 900 ANEKLGNQLRE 910



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 102/472 (21%), Positives = 207/472 (43%), Gaps = 70/472 (14%)

Query: 215 EKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNL 274
           E E  + + +  QEQK+     V+  Q +   L+   +A ++ K  ++MK + + ++ +L
Sbjct: 300 ECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQK-RNIMKDMMK-LELDL 357

Query: 275 YMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLEL---ESKINEINTEINQLIEKKM 331
           + + E+    +E K K++  LQ  + E  +  ++  +L   + K  +   E+ Q +EKK+
Sbjct: 358 HGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKL 417

Query: 332 --MRNEPIEGKLSLYRQQASIISRK---KEAKAE------------ELQEAKEKLASLER 374
             ++N  ++ +  L +QQ      +   KEAK +            E+Q+ K  L   ++
Sbjct: 418 TQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQ 477

Query: 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQ----- 429
           +  +   Q  +      L G   +    KL+    + K+K   I EL+ E  +LQ     
Sbjct: 478 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSM 537

Query: 430 ----------RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQ-----EELERVSALKSE 474
                     R EEL  +  E +++   + +EK+ +      Q     + L+R+     E
Sbjct: 538 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 597

Query: 475 VDEMKGRTLDDMSEMVKKL------YSLVSEKKSALASVIKELRQ--------LRQKYQE 520
              +K +  +D+ E  K L           E +  +   ++ LRQ        L++  ++
Sbjct: 598 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 657

Query: 521 LTQECDEKKSQYDSCAAGLESNRSKL---EQEVRRLREE-CLQEESRYHYTNCMIKNLEV 576
           L +E +  +++   C+  LES+ +K    +Q ++ L +E  LQ+ES        + +L+ 
Sbjct: 658 LEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKES--------LMSLQA 709

Query: 577 QLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRES 628
           QL +A  + K Y+ +     ++A      K+ A Q++L + L +   V  E+
Sbjct: 710 QLDKALQKEKHYLQT--TITKEAYDALSRKSAACQDDLTQALEKLNHVTSET 759



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 111/590 (18%), Positives = 238/590 (40%), Gaps = 66/590 (11%)

Query: 124 KLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183
           KL+     L +E + + N+   E       LH   EQL ++G   A + + ++   ++  
Sbjct: 133 KLKEDEVILYEEEMGNHNENTGE------KLHLAQEQLALAGDKIASLERSLNLYRDKYQ 186

Query: 184 QLIKRVEHLKKRVETAQNH------QWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV 237
             +  +E L+ +V+  Q        Q         +V       + Q+ QE + +L    
Sbjct: 187 SSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVW 246

Query: 238 QRLQRVQNQLKSMRQAAADAKPESLMKR---LEEEIKFNLYMVTEKFP----KELENKKK 290
           Q++ +  + ++ +R   A +    L +    ++ +  F     T ++P    +E E+ KK
Sbjct: 247 QKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKK 306

Query: 291 ELHFLQ------------------------KVVSEPAMG-HSDLLELESKINEINTEINQ 325
            L  LQ                        + VSE       D+++LE  ++ +  E + 
Sbjct: 307 ILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSA 366

Query: 326 LIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTRE 385
            IE+K      ++ +L   + + +   +    K + LQE  E L  LE++ +  +N   +
Sbjct: 367 HIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLK 426

Query: 386 FDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQ 445
            +  E+ K       +     ++   K K      L+AE   L+ + E  KQ+     QQ
Sbjct: 427 KE-KELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQ 485

Query: 446 LQTMEEKKGISG--YSYTQEELERVSALKSEVDEMKGRTLDDMS---EMVKKLYSLVSEK 500
               +E+  ++G     TQ +L++   L    D+ K  T+ ++    +M++K  S+  ++
Sbjct: 486 AAQCKEEAALAGCHLEDTQRKLQKGLLL----DKQKADTIQELQRELQMLQKESSMAEKE 541

Query: 501 KSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREE---- 556
           +++    ++EL     +     +  D++K Q     A  +   + +   ++    E    
Sbjct: 542 QTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI 601

Query: 557 -CLQEESRYHYTNCMIKNLEVQLRRATDEMKAY------ISSDQQEKRKAIREQYTKNTA 609
            C  EE     T  ++++   QL+++ +  K        +  + ++K K ++E   K   
Sbjct: 602 KCKLEEDLQEATK-LLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE 660

Query: 610 EQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659
           E ENL  +L+     +  S        ++ +DL + +  +K+  +  Q+Q
Sbjct: 661 ENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQ 710



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 102/539 (18%), Positives = 214/539 (39%), Gaps = 85/539 (15%)

Query: 208 IARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMK--- 264
           ++ QL ++   +    Q+K  Q NQL      ++   N     +QA A A  ES ++   
Sbjct: 20  LSLQLDIKNLHDVCKRQRKTLQDNQLC-----MEEAMNSSHDKKQAQALAFEESEVEFGS 74

Query: 265 ------RLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINE 318
                 R  +++K  L ++ ++     E  +   + L++  S      SDL+ L      
Sbjct: 75  SKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKL 134

Query: 319 INTEINQLIEKKMMRNEPIEGKLSLYRQQASI-------ISRKKEAKAEELQEAKEKLAS 371
              E+    E+    NE    KL L ++Q ++       + R      ++ Q +   +  
Sbjct: 135 KEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIEL 194

Query: 372 LEREASVKRNQTREFDGTE-VLKGDEFKRYV----------------------------- 401
           LE +  + + +     G E   KGD  K  +                             
Sbjct: 195 LECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDD 254

Query: 402 ------NKLRSKSTVFKKKHQIIAELKAEFGLLQRTEEL---LKQRHENIQQQLQTMEEK 452
                 NKL   + +  ++ + + +L+A+F     T        +  E+I++ L+ ++E+
Sbjct: 255 LIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQ 314

Query: 453 KGISGYSYTQEELERVSALKSE---VDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIK 509
           K  S   + +E    V  L+ E   V E K   + DM ++   L+ L  E  + +    K
Sbjct: 315 KD-SQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDK 373

Query: 510 ELRQLRQKYQELTQECDEKKS---QYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHY 566
           ++  L+ + QEL  E  E +    + D      +    +LE+++ +++   L++E     
Sbjct: 374 DITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEK 433

Query: 567 TNCMIKNLEVQLRRA----------------TDEMKAYISSDQQEKRKAIREQYTKNTAE 610
             CM   LE+ ++ A                  ++K  +   +Q++R A  +Q  +   E
Sbjct: 434 QQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLA-AQQAAQCKEE 492

Query: 611 QENLGKKLREKQKVIRESHGPNMKQAKMWRDLE-QLMECKKQCFLKQQSQTSIGQVIQE 668
               G  L + Q+ +++    + ++A   ++L+ +L   +K+  + ++ QTS  + ++E
Sbjct: 493 AALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEE 551


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 122/616 (19%), Positives = 255/616 (41%), Gaps = 87/616 (14%)

Query: 48  KQLVDIREEMPEQTAKRMLSLLGI------LKYKPSGNATDMSTFRQGLVIGSKPVIYPV 101
           K+LV ++  M   T +R      +      L+ + + +   +S  R  L  G + V   V
Sbjct: 228 KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287

Query: 102 --LHWLLQRTNEL-KKRAYLARFLIKLEVPSEFLQD----ETVADTN------------K 142
             L  L    NEL +K   L   L+K E     L++    E+V+  N            +
Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347

Query: 143 QYEELMEAFKT-LHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201
           Q +  + A +T LH+ + +L   G +T ++++++S +E        + +HLK        
Sbjct: 348 QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVET-------KYQHLKAEF----- 395

Query: 202 HQWMLKIARQLRVEKEREEYLAQQKQEQKNQ----LFHAVQRLQRVQNQLKSMRQAAADA 257
                   +QL+ ++E +E    Q Q + NQ    L    ++L     +LK  RQ ++  
Sbjct: 396 --------KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS-- 445

Query: 258 KPESLMKRLEE--EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESK 315
             E LM + ++  +++  L  + E+  +++ N  +  H L K   +     +      +K
Sbjct: 446 --EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK 503

Query: 316 INEINTEINQLIEK---KMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASL 372
           + E   ++ Q++ +   K  + + +E  L   ++  S++ +++E    ++Q  + + A L
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 563

Query: 373 EREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTE 432
            +    ++N T +   T++      ++  N+  S     +  H  + E KA     Q   
Sbjct: 564 NQ--LQEKNHTLQEQVTQLT-----EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616

Query: 433 ELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKK 492
             L+     +  QL   +EK      S    +++  + L    +  K     D+   +  
Sbjct: 617 LSLETSVNELNSQLNESKEK-----VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT 671

Query: 493 LYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS---QYDSCAAGLESNRSKLEQE 549
             + + +K+  L  +  +L Q+  K Q+  + C + +S   +Y      LE    +LE +
Sbjct: 672 AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ 731

Query: 550 VRRL----------REECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISS---DQQEK 596
           +++L          +E+ LQ+  +    N  ++    +L +  +  K  +SS   D Q+K
Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791

Query: 597 RKAIREQYTKNTAEQE 612
            +A+     K T ++E
Sbjct: 792 SEALESIKQKLTKQEE 807



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 90/493 (18%), Positives = 208/493 (42%), Gaps = 62/493 (12%)

Query: 132 LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVE- 190
           LQ  T A   +   +L +  + +  + ++++       + +++IS +E+E++ L  +++ 
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555

Query: 191 ---------HLKKRVETAQNHQWML--KIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239
                     L+++  T Q     L  K+  Q    K+ +E L  Q QEQK  L  A  R
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615

Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFP---------------KE 284
           +  ++  +  +     ++K +     ++ + K  L +  E                    
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675

Query: 285 LENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKM---MRNEPIEGKL 341
           L++K++EL+   K+ ++     + L + +   +++ + + +  EK +    + E +EG++
Sbjct: 676 LQDKQQELN---KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732

Query: 342 SLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYV 401
                 +  +   KE   ++LQ+ ++    LE  A            TE+ K  E ++ +
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA------------TELSKQLEMEKEI 780

Query: 402 NKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYT 461
             + S     +KK + +  +K +    +  +++LKQ  E + Q+ +   E+   +    T
Sbjct: 781 --VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELN-NRIQTT 837

Query: 462 QEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQEL 521
             EL++V   K  +       + ++S +  KL  +    K++ +   KE ++ +    +L
Sbjct: 838 VTELQKVKMEKEAL-------MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL 890

Query: 522 TQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRA 581
            + C E K Q       L+       +E + L++   +E+   H     + +++ QL +A
Sbjct: 891 EKTCKELKHQ-------LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA 943

Query: 582 TDEMKAYISSDQQ 594
            + +K     +QQ
Sbjct: 944 QNTLKQNEKEEQQ 956



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 104/538 (19%), Positives = 222/538 (41%), Gaps = 72/538 (13%)

Query: 135 ETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKK 194
           + V D     +E     + L KE E  K  G    E + D    +   +     ++ L++
Sbjct: 90  QEVQDLQASLKEEKWYSEELKKELE--KYQGLQQQEAKPDGLVTDSSAE-----LQSLEQ 142

Query: 195 RVETAQNHQWMLKIARQLRVEKERE-----EYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249
           ++E AQ   + +K  + L  +K  +       +  +  E+++    A Q++ R+  +L  
Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK 202

Query: 250 MRQAAADAKPESLMKRLEEEIKF-------------NLYMVTEKFPKELENKKKELHF-- 294
                 D K E L +   E++               N+ +  E+  ++L+++ K+L    
Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQY 262

Query: 295 -------------LQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKL 341
                        L K   E A+   +L +L+S +NE+ T+ NQ + + +++ E    KL
Sbjct: 263 ASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL-TQKNQTLTENLLKKEQDYTKL 321

Query: 342 SLYRQQASIISRKKEA----KAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEF 397
                + S+  +  +A    K  + Q+ + +L++ E        +  E       KG+  
Sbjct: 322 EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE-------KGEA- 373

Query: 398 KRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISG 457
                KL+ + +  + K+Q    LKAEF  LQ+  E  +Q    +Q ++  +  K     
Sbjct: 374 ---TQKLKEELSEVETKYQ---HLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK----- 422

Query: 458 YSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQK 517
              T+ +L        E  ++    L D  + V  L   +S  +  L   +    +L+ +
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482

Query: 518 YQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLRE--------ECLQEESRYHYTNC 569
             +  Q+  E+++   S  A L   ++ LEQ +R++ +        E L ++S+ + +  
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542

Query: 570 MIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRE 627
             +  ++  +    E +  + +  QEK   ++EQ T+ T + +N  +  ++ Q+ + +
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 114/564 (20%), Positives = 236/564 (41%), Gaps = 82/564 (14%)

Query: 114  KRAYLARFLIKLEVPSEFLQD--ETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEI 171
            K+  L +   +L+  +  LQD  E  +      +E  E + +L ++ E+L+         
Sbjct: 679  KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738

Query: 172  RKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKN 231
              ++ A +E+  Q +++   L   +E         ++++QL +EKE         Q++  
Sbjct: 739  SLEVKASKEQALQDLQQQRQLNTDLELRAT-----ELSKQLEMEKEIVSSTRLDLQKKSE 793

Query: 232  QLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLE-------------------EEIKF 272
             L    Q+L + + + + ++Q       E+ ++  E                   E +  
Sbjct: 794  ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMT 853

Query: 273  NLYMVTEKFPK---ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEK 329
             L  V +K  K    L+N K E         E   G + +L+LE    E+  ++   +E 
Sbjct: 854  ELSTVKDKLSKVSDSLKNSKSEFE------KENQKGKAAILDLEKTCKELKHQLQVQMEN 907

Query: 330  KMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREA--------SVKRN 381
             +   + ++  L   ++ +  +  +  +  E+L +A+  L   E+E          +K++
Sbjct: 908  TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967

Query: 382  QTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAE---FGLLQ----RTEEL 434
              ++    E L+G+     + K   ++ + ++  Q   EL AE     +LQ    +++E 
Sbjct: 968  SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027

Query: 435  LKQRHENI----------QQQLQTMEEKKGISGYSYTQEEL----ERVSALKSEVDEMKG 480
             KQ   +           +Q L+++EEK      S  QE+L     ++      + E+K 
Sbjct: 1028 FKQLQSDFYGRESELLATRQDLKSVEEK-----LSLAQEDLISNRNQIGNQNKLIQELKT 1082

Query: 481  RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540
                   +  KK   L  E+  AL  + KE + L++K  EL  E   K ++ +      E
Sbjct: 1083 AKATLEQDSAKKEQQL-QERCKALQDIQKE-KSLKEK--ELVNE-KSKLAEIEEIKCRQE 1137

Query: 541  SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKR--K 598
               +KL +E++  + E ++E +       ++   +++L+   D +KA +   +QEKR  +
Sbjct: 1138 KEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV---EQEKRNQQ 1194

Query: 599  AIREQYTKNTAEQENLGKKLREKQ 622
             +++Q  K   E+E L K+  EK+
Sbjct: 1195 ILKDQVKK---EEEELKKEFIEKE 1215



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 99/498 (19%), Positives = 208/498 (41%), Gaps = 55/498 (11%)

Query: 123  IKLEVPSEFLQDETVADT-NKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDIS-AMEE 180
            +K+E  +   +  TV D  +K  + L  +     KE ++ K +     +  K++   ++ 
Sbjct: 844  VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903

Query: 181  EKDQLIKRVEHLKKRVETAQNHQWMLKIA-RQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239
            + +  +K  + LKK +E  +     LK+    ++ +  + +   +Q ++++ QL   +  
Sbjct: 904  QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963

Query: 240  LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV 299
            L++   Q K   +A       +++++ E E K    +   +  +EL  +K+++  LQ   
Sbjct: 964  LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT--QAAQELAAEKEKISVLQNNY 1021

Query: 300  SEPAMG----HSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355
             +         SD    ES++     ++  + EK  +  E +    +    Q  +I   K
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK 1081

Query: 356  EAKA----------EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLR 405
             AKA          ++LQE  + L  +++E S+K  +    + +++ + +E K    K  
Sbjct: 1082 TAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN-EKSKLAEIEEIKCRQEKEI 1140

Query: 406  SKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEEL 465
            +K     K H++  E   E   L+  ++LL      IQQ+L+   + K  S  +  ++E 
Sbjct: 1141 TKLNEELKSHKL--ESIKEITNLKDAKQLL------IQQKLEL--QGKADSLKAAVEQEK 1190

Query: 466  ERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKK---------------------SAL 504
                 LK +V + +     +  E   KL+S + EK+                       L
Sbjct: 1191 RNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL 1250

Query: 505  ASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRY 564
             +V KE +  +++  EL ++ D+ + +     A +++N    + E R L E CL+ E   
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNN----QDERRALLERCLKGEGEI 1306

Query: 565  HYTNCMIKNLEVQLRRAT 582
                  +  L+ +L   T
Sbjct: 1307 EKLQTKVLELQRKLDNTT 1324



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 111/528 (21%), Positives = 226/528 (42%), Gaps = 71/528 (13%)

Query: 124  KLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183
            +LE+  E +   T  D  K+ E L    + L K+ E+ +I       +++D   + +E  
Sbjct: 773  QLEMEKEIVSS-TRLDLQKKSEALESIKQKLTKQEEEKQI-------LKQDFETLSQET- 823

Query: 184  QLIKRVEH--LKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQ 241
                +++H  L  R++T            +L+  K  +E L  +    K++L      L+
Sbjct: 824  ----KIQHEELNNRIQTT---------VTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870

Query: 242  RVQNQLKSMRQA--AADAKPESLMKRLEEEIKF---NLYMVTEKFPKELENKKKELHFLQ 296
              +++ +   Q   AA    E   K L+ +++    N     ++  K LE +K+  H L+
Sbjct: 871  NSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLK 930

Query: 297  ----KVVSEPAMGHSDLLELESKINEINTEINQL---IEKKMMRNEPIEGKLSLYRQQAS 349
                 +  +     + L + E +  ++   IN+L    E+K  + E ++G+L +   Q +
Sbjct: 931  LELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT 990

Query: 350  IISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKST 409
             +  K +   ++L +A ++LA+ + + SV +N   +   T       FK+  +    + +
Sbjct: 991  ELENKLQ---QQLTQAAQELAAEKEKISVLQNNYEKSQET-------FKQLQSDFYGRES 1040

Query: 410  VFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVS 469
                  Q +  ++ +  L Q  E+L+  R++ I  Q + ++E K        +  LE+ S
Sbjct: 1041 ELLATRQDLKSVEEKLSLAQ--EDLISNRNQ-IGNQNKLIQELKT------AKATLEQDS 1091

Query: 470  ALKSEVDEMKGRTLDDMS-EMVKKLYSLVSEKKSALASVI-------KELRQLRQKYQEL 521
            A K +  + + + L D+  E   K   LV+EK S LA +        KE+ +L ++ +  
Sbjct: 1092 AKKEQQLQERCKALQDIQKEKSLKEKELVNEK-SKLAEIEEIKCRQEKEITKLNEELKSH 1150

Query: 522  TQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRA 581
              E  ++ +        L   + +L+ +   L+    QE+         +K  E +L++ 
Sbjct: 1151 KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKE 1210

Query: 582  TDEMKAYISSDQQEKRKAIREQYTKN-------TAEQENLGKKLREKQ 622
              E +A + S+ +EK   +++            TA  ENLG   +E Q
Sbjct: 1211 FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQ 1258



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 61/314 (19%), Positives = 144/314 (45%), Gaps = 24/314 (7%)

Query: 366 KEKLASLEREASVKRNQTREFDGT---EVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELK 422
           +  LA    + ++ R + ++   +   E    +E K+ + K +       K   ++ +  
Sbjct: 75  ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134

Query: 423 AEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRT 482
           AE   L++  E  +  + NI+Q     E+K          +    ++ +KS+ DE +   
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAA--------QLATEIADIKSKYDEERS-- 184

Query: 483 LDDMSEMVKKLYSLVSEKKSALASVIKELR-QLRQKYQELTQECDEKKSQYDSCAAGLES 541
              + E  ++  + ++E+ +  A+VI++L+ +L Q+     ++    K +       +++
Sbjct: 185 ---LREAAEQKVTRLTEELNKEATVIQDLKTELLQRPG--IEDVAVLKKELVQVQTLMDN 239

Query: 542 NRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIR 601
              + E+E  +L++EC + +S+Y  +   I  L  +L +   E+  Y+  + Q+ + ++ 
Sbjct: 240 MTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV-QELQKLKSSVN 298

Query: 602 EQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL-MECKKQCFLKQQSQT 660
           E   KN    ENL KK ++  K+  + +  ++ +  +   L Q  ++C++       S+T
Sbjct: 299 ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASET 358

Query: 661 SIGQV---IQEGGE 671
           S+ ++   + E GE
Sbjct: 359 SLHRIHVELSEKGE 372



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 103/491 (20%), Positives = 220/491 (44%), Gaps = 64/491 (13%)

Query: 214 VEKEREEYLAQQKQEQ--KNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIK 271
           + +E ++  A  K+E+    +L   +++ Q +Q Q         +AKP+ L+     E++
Sbjct: 88  LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQ---------EAKPDGLVTDSSAELQ 138

Query: 272 FNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKM 331
                + E   +    K+ +  F QK     A   +++ +++SK +E    + +  E+K+
Sbjct: 139 SLEQQLEEAQTENFNIKQMKDLFEQKA----AQLATEIADIKSKYDE-ERSLREAAEQKV 193

Query: 332 MRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAK-EKLASLEREA----SVKRNQTREF 386
            R   +  +L+   ++A++I   ++ K E LQ    E +A L++E     ++  N T E 
Sbjct: 194 TR---LTEELN---KEATVI---QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLER 244

Query: 387 DGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQL 446
           +       DE K+  ++  S      +    +A+   E  +  +  + LK     + Q+ 
Sbjct: 245 ERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304

Query: 447 QTMEEK--KGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSAL 504
           QT+ E   K    Y+  +E+    S  K  +      TL       ++L S +S  +++L
Sbjct: 305 QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA----TLHQKDLDCQQLQSRLSASETSL 360

Query: 505 ASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRY 564
             +  EL +      E TQ+  E+ S+ ++    L++   +L+Q+     +  LQ +S  
Sbjct: 361 HRIHVELSEKG----EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI 416

Query: 565 HYTNCMIKNLEVQLRRATDEMK--AYISSDQ---QEKRKA------------IREQYTKN 607
           +  +  +   E QL  A   +K    +SS++   +E++ A            ++E+ T +
Sbjct: 417 NQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNS 476

Query: 608 TAEQENLG--KKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQV 665
           T  Q  L   K+  ++Q+ +++S    +++A+   DLEQ++   +Q   K Q   ++  +
Sbjct: 477 TELQHQLDKTKQQHQEQQALQQSTTAKLREAQ--NDLEQVL---RQIGDKDQKIQNLEAL 531

Query: 666 IQEGGEDRLIL 676
           +Q+  E+  +L
Sbjct: 532 LQKSKENISLL 542


>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
          Length = 2479

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 109/508 (21%), Positives = 223/508 (43%), Gaps = 64/508 (12%)

Query: 111  ELKKRAY-LARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTA 169
            ELKKR   L   ++ +       +D  V D + Q   L E    L K++ +   S  S +
Sbjct: 1988 ELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSIS 2047

Query: 170  EIRKDISAMEEE---KDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQK 226
             I  D     E+   K+ L    E+++ + +  Q ++ + ++  Q+R  KE  E+L ++K
Sbjct: 2048 GIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEK 2107

Query: 227  QEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEI--------KFNLYMVT 278
             E + +L H       V+   +S +      K   LMK++ E++        K +  + +
Sbjct: 2108 AEVQRKLGH-------VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS 2160

Query: 279  EKFPK-ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEI--NQLIEKKMMRNE 335
            EK    E EN+K +   L+K+ +   +GH   +  ESK       I  N+ + K++ +  
Sbjct: 2161 EKMANIEQENEKLKAE-LEKLKAH--LGHQLSMHYESKTKGTEKIIAENERLRKELKKET 2217

Query: 336  PIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGD 395
                KL + +    I++ K   + EE  +  +   S  R   ++   ++ +    V +  
Sbjct: 2218 DAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAES--RGPQLEGADSKSWKSIVVTR-- 2273

Query: 396  EFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGI 455
                Y  KL+   T   KK+Q I +LK         E+ + + +E+++QQ++ ++     
Sbjct: 2274 ---MYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILK----- 2325

Query: 456  SGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEK-KSALASVIKELRQL 514
                +  E  E    LK E+  ++        E  + ++ + + K +S   S I +  QL
Sbjct: 2326 ----HVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQL 2381

Query: 515  RQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQ---------EESRYH 565
            ++K ++L  E   K S  +         +  L++E+++L++E            E+ +Y+
Sbjct: 2382 KEKIKDL--ETQLKMSDLE---------KQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430

Query: 566  YTNCMIKN--LEVQLRRATDEMKAYISS 591
            Y   + KN  LE ++++ ++++   ++S
Sbjct: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTS 2458



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 121/596 (20%), Positives = 241/596 (40%), Gaps = 77/596 (12%)

Query: 129 SEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKR 188
           + FL++E +    KQ E+     + + KE E+ K       ++ + ++   EE +    +
Sbjct: 110 TRFLRNE-ICQLEKQLEQKDRELEDMEKELEKEK-------KVNEQLALRNEEAENENSK 161

Query: 189 VEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQ--KNQLFHAVQRLQRVQNQ 246
           +    KR++          I  Q +++ ++E  L+++ ++   ++QL      L +  ++
Sbjct: 162 LRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDE 221

Query: 247 LKSMRQA--AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304
           ++++ +A    + + + + K LEE ++       EK   E    K  +H    V+     
Sbjct: 222 IQTLTEANEKIEVQNQEMRKNLEESVQ-----EMEKMTDEYNRMKAIVHQTDNVI----- 271

Query: 305 GHSDLLELESKINEINT-EINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ 363
              D L+ E+   ++   E+  L++ K   ++PI   ++   ++  +I   K+ +  E Q
Sbjct: 272 ---DQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQ 328

Query: 364 EA----KEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIA 419
           +     +EKL + + +A  K N      G +  +  + K    ++   +   +K   II 
Sbjct: 329 QMLHNLREKLKNAQLDAD-KSNVMALQQGIQE-RDSQIKMLTEQVEQYTKEMEKNTCIIE 386

Query: 420 ELKAEFGLLQRTEELLKQRHENIQQQLQTMEEK-------KGISGYSYTQEELERVSALK 472
           +LK E    +    L +Q H  IQ  L  ++EK         ++     +++ E V ALK
Sbjct: 387 DLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALK 446

Query: 473 SEVDEMKG-RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECD----- 526
              D   G   L+D    +K   + +  +   +  + KE+ +L  K  +   E +     
Sbjct: 447 RLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRER 506

Query: 527 ---EKKSQYDSC----AAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLR 579
              E K+  D      +  L+  + + E ++     E L+EE             E   R
Sbjct: 507 VGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKR 566

Query: 580 RATD-------EMKAYISSDQQEKRKAIREQYTKNTAE----QENLGKKLREKQKVIRES 628
            AT         +   IS   +   + +     KN +E     E L ++L EK++ +  S
Sbjct: 567 SATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERS 626

Query: 629 HGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQE--------GGEDRLIL 676
                  AK    L++L+E  KQ    ++    I Q I+E        GGE  LI+
Sbjct: 627 ---RTVIAKFQNKLKELVEENKQL---EEGMKEILQAIKEMQKDPDVKGGETSLII 676



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 136/627 (21%), Positives = 248/627 (39%), Gaps = 149/627 (23%)

Query: 147  LMEAFKT-LHKEYEQLKISGFSTAEIRKDISAMEEEK--------------DQLIKR-VE 190
            L+E  K+ L  + +Q K    +  E+R +++A  EE+               Q++ R   
Sbjct: 1726 LVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTR 1785

Query: 191  HLKKRVETAQNHQWMLKIARQLRVEKEREEYLA----------QQKQEQKNQLFHAVQRL 240
             LK +VE    +  +LK+   L+  K RE  L           Q+KQ+  N++    + +
Sbjct: 1786 ELKTQVEDLNEN--LLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEI 1843

Query: 241  QRVQNQLKSMRQ---AAADAKP-----ESLMKRLEEEIK------------FNLYMVTEK 280
             +  ++LK   +   +    KP     +SL++ L+ ++K             +L  + EK
Sbjct: 1844 DQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEK 1903

Query: 281  FPKE---------------------LENKKKELHFLQKVVSEP----AMGHSDLLELESK 315
              KE                     L+ K+ E+  L K ++      A    + L L+ K
Sbjct: 1904 NAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRK 1963

Query: 316  INEINTEINQL-----------IEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQE 364
            +      ++Q+           +E+   RN  +E  + LY +    + R    +   LQ 
Sbjct: 1964 LKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDI-LYMRAHQALPRDSVVEDLHLQN 2022

Query: 365  --AKEKLASLEREASVKRNQTREFDGTE----VLKGDEFKRYVNKLRSKSTVFK----KK 414
               +EKL +LE++ S          G E      +  E ++   KL S++   K    + 
Sbjct: 2023 RYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQA 2082

Query: 415  HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474
            ++ +  LK +   L+   E LK+    +Q++L  +   +G      T  ELE+   L  +
Sbjct: 2083 NKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHV---RGSGRSGKTIPELEKTIGLMKK 2139

Query: 475  VDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS-QYD 533
            V E   R     +E +KK   +++ +K  +A++ +E  +L+ + ++L      + S  Y+
Sbjct: 2140 VVEKVQRE----NEQLKKASGILTSEK--MANIEQENEKLKAELEKLKAHLGHQLSMHYE 2193

Query: 534  SCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ 593
            S   G E    K+  E  RLR+E  +E            NLE+                 
Sbjct: 2194 SKTKGTE----KIIAENERLRKELKKETDAAEKLRIAKNNLEI----------------- 2232

Query: 594  QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQA--KMWRDL-------EQ 644
                  + E   K T + E  GK+L+       ES GP ++ A  K W+ +        +
Sbjct: 2233 ------LNE---KMTVQLEETGKRLQ-----FAESRGPQLEGADSKSWKSIVVTRMYETK 2278

Query: 645  LMECKKQCFLKQQSQTSIGQVIQEGGE 671
            L E +     K QS T + Q+++E  E
Sbjct: 2279 LKELETDIAKKNQSITDLKQLVKEATE 2305



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 89/444 (20%), Positives = 187/444 (42%), Gaps = 56/444 (12%)

Query: 212 LRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIK 271
           + + K     L  +KQE    LF       R+   L  M+    +   E + K  EE+ K
Sbjct: 30  ISLSKVEVNELKSEKQENVIHLF-------RITQSLMKMKAQEVELALEEVEKAGEEQAK 82

Query: 272 FNLYMVTE--KFPKELENKK-----KELHFLQKVVS--EPAMGHSDLLELESKINEINTE 322
           F   + T+  K   ELE  +     ++  FL+  +   E  +   D  ELE    E+  E
Sbjct: 83  FENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKD-RELEDMEKELEKE 141

Query: 323 INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382
             ++ E+  +RNE  E + S  R++   + +K E   +++ + ++++ S +     +R +
Sbjct: 142 -KKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGE 200

Query: 383 TREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENI 442
             ++      K  E  +Y++++++ +   +K             +  + +E+ K   E++
Sbjct: 201 DSDYRSQLSKKNYELIQYLDEIQTLTEANEK-------------IEVQNQEMRKNLEESV 247

Query: 443 QQQLQTMEEKKGISGYSYTQEELERVSALKSE-----------VDEMKGRTLDDMSEMVK 491
           Q+  +  +E   +    +  + +  +  LK E            D +K +  +D   MV 
Sbjct: 248 QEMEKMTDEYNRMKAIVHQTDNV--IDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMV- 304

Query: 492 KLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYD---SCAAGLESNRSKLEQ 548
            + + V E K  L+S   E+ + +Q    L ++   K +Q D   S    L+    + + 
Sbjct: 305 AVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKL--KNAQLDADKSNVMALQQGIQERDS 362

Query: 549 EVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNT 608
           +++ L E+  Q         C+I++L+ +L+R  ++  + +S     K ++  +   + T
Sbjct: 363 QIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR--NKGASTLSQQTHMKIQSTLDILKEKT 420

Query: 609 AEQENLGK----KLREKQKVIRES 628
            E E   +      REK K + E+
Sbjct: 421 KEAERTAELAEADAREKDKELVEA 444



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 119/597 (19%), Positives = 233/597 (39%), Gaps = 107/597 (17%)

Query: 105  LLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYE-QLKI 163
            L++   E+K   YL   + + E     L++E V   NK +EE   A+     + E QL I
Sbjct: 1365 LVKDKEEIK---YLNNIISEYERTISSLEEEIVQQ-NKFHEERQMAWDQREVDLERQLDI 1420

Query: 164  SGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKERE---E 220
                  EI       EE    +      L  ++E A     + KI   +R+  E     +
Sbjct: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIA-----LRKIKENIRIILETRATCK 1475

Query: 221  YLAQQKQEQKNQLFHAVQRL---QRVQNQLKSMRQAAADAKP---ESLMKRLEEEIKFNL 274
             L ++ +E+++ L  A Q +    +V N+L+    A A+ +    E   K +E +    L
Sbjct: 1476 SLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTL 1535

Query: 275  YM-----------------VTEKFPKELENKKKELHFLQKVVSEPA--MGHSDLLELESK 315
             +                 V +K+ + LE  ++E   + K   E    + H   L+ +S 
Sbjct: 1536 KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSS 1595

Query: 316  INEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE 375
            +N+       L+ K+     P         +    ++ + ++ +  L + K+    LER+
Sbjct: 1596 LNKFKQTAWDLM-KQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQ 1654

Query: 376  ASVKRNQTREFDGTEVLKGDEFKRYVNKLRS-------------------KSTVFKKK-- 414
              +   + +EF+  ++   +  +  V K+++                   KS +  +K  
Sbjct: 1655 REITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEA 1714

Query: 415  ---------HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEEL 465
                       ++  LK++  L ++ ++ L +    ++ ++    E++ IS  S  +  L
Sbjct: 1715 NSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHL 1774

Query: 466  ERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQ------ 519
                 +     E+K + ++D++E + KL   +   K+   S+   L  L  + Q      
Sbjct: 1775 NVQQIVDRHTRELKTQ-VEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY 1833

Query: 520  --------ELTQECDEKKSQYDSCAAGLE-----SNRSKLEQEVRRLREECLQEESRYHY 566
                    E+ QE DE K Q     +GL+      N+  L +E++R              
Sbjct: 1834 NKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQR-------------- 1879

Query: 567  TNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIR-EQYTKNTAEQENLGKKLREKQ 622
                +K LE QL    +E+      ++  K + IR E+  K  A+ E +  KL+EK+
Sbjct: 1880 ---KVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKE 1933



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 115/570 (20%), Positives = 235/570 (41%), Gaps = 104/570 (18%)

Query: 98  IYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKE 157
           I   L  L ++T E ++ A LA                  AD  ++ +EL+EA K L K+
Sbjct: 409 IQSTLDILKEKTKEAERTAELAE-----------------ADAREKDKELVEALKRL-KD 450

Query: 158 YE------------------QLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETA 199
           YE                  Q+KI       + K+I+ +E +    +   E L++RV   
Sbjct: 451 YESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERV--G 508

Query: 200 QNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQ-LFHAVQRLQRVQNQLKS-MRQAAADA 257
              + M+ +      E    ++L QQ+   +NQ L   ++ L+  +  LK  +RQ A + 
Sbjct: 509 LEPKTMIDLT-----EFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563

Query: 258 KPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKIN 317
              S    L  E   NL   TE   +     +++L  L            ++ E +SK  
Sbjct: 564 GKRSATSGLTTE-DLNL---TENISQGDRISERKLDLLSL---------KNMSEAQSKNE 610

Query: 318 EINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREAS 377
            ++ E+ +  E+ + R+  +  K     +   ++   K+ + E ++E  + +  ++++  
Sbjct: 611 FLSRELIEK-ERDLERSRTVIAKFQ--NKLKELVEENKQLE-EGMKEILQAIKEMQKDPD 666

Query: 378 VKRNQTREFDGTEVLKGDEFKRYVNKLRSKST--VFKKKHQIIAELKAEFGLLQRTEELL 435
           VK  +T        L     +R VN + SK+   +F     + A++    G   R EEL 
Sbjct: 667 VKGGETS-------LIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTG---RNEELR 716

Query: 436 KQRHENIQQQLQTMEEKKGISGYSYTQEELERVSAL--KSEVDEMKGRTLDDMSEMVKKL 493
           ++  E+ ++ +   ++   ++  +   + LE+ ++L  +SE   +  + +D    +    
Sbjct: 717 QELRESRKEAINYSQQ---LAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSS 773

Query: 494 YSLVSEKKSALASVIKELRQLRQKYQELTQECDEKK--------------SQYDSCAAGL 539
            S+++ +   L  +++EL    +K + L    ++                 +Y S     
Sbjct: 774 ASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETW 833

Query: 540 ESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ------ 593
           ++    +++E R+L ++  Q+  +    N ++  L++     +DEMK  ++ +       
Sbjct: 834 KTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMD----SDEMKKILAENSRKITVL 889

Query: 594 QEKRKAIREQYTKNTAEQENLGKKLREKQK 623
           Q   K++  QYT    E E   +K  EKQK
Sbjct: 890 QVNEKSLIRQYT-TLVELERQLRKENEKQK 918



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 105/575 (18%), Positives = 238/575 (41%), Gaps = 81/575 (14%)

Query: 117  YLARFLIKLEVPSEFLQ--DETVADTNKQYEELMEAFKTLHKEY---------------- 158
            YL   L +LE   + L+  ++++ D N+++  +      L+KEY                
Sbjct: 783  YLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKE 842

Query: 159  ------EQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQL 212
                  +Q++       E    ++A++ + D++ K +    +++   Q ++    + RQ 
Sbjct: 843  EKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNE--KSLIRQY 900

Query: 213  RVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKF 272
                E E  L ++ ++QKN+L      +      L+  ++ A   K  +L K ++  +  
Sbjct: 901  TTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAI-FKIAALQKVVDNSVSL 959

Query: 273  NLYMVTEKFPKELENKKKEL----HFLQKVVSEPAMGHSDLLELESKINEINTEINQLIE 328
            +   +  K   EL  K +++    + L +  S       + + L+ ++  IN E+ ++ +
Sbjct: 960  SELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKEL-EITK 1018

Query: 329  KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDG 388
            +K+   E    + +    ++S+   KK     ++    +K+  LE +   +R        
Sbjct: 1019 EKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQ------- 1071

Query: 389  TEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQT 448
                + +  ++    LR   T  K+  +   EL+ +F       EL K   +   Q+++ 
Sbjct: 1072 ----RAEHCQKMYEHLR---TSLKQMEERNFELETKFA------ELTKINLD--AQKVEQ 1116

Query: 449  MEEKKGISGYSYTQEELERVSALKSEVDEMKGRT----LDDMSEMVKKLYSLVSEKKSAL 504
            M   +     S    + +R   L+ E +EM+ +     L ++S++ ++   +++ ++   
Sbjct: 1117 MLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQ-- 1174

Query: 505  ASVIKELRQLRQKYQELTQECDEKK------------SQYDSCAAG-LESNRSKLEQEVR 551
             S  KE+  LR +  +   + DEK                ++ A G LES  SKL++   
Sbjct: 1175 -SRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEA 1233

Query: 552  ---RLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNT 608
               RL ++  ++E   +Y     +N    LR+    ++   S        A +E+++K  
Sbjct: 1234 YNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSG---ALPLAQQEKFSKTM 1290

Query: 609  AEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLE 643
             + +N   K+ ++ K  ++ H  NM+   +  +L+
Sbjct: 1291 IQLQNDKLKIMQEMKNSQQEH-RNMENKTLEMELK 1324



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 93/439 (21%), Positives = 178/439 (40%), Gaps = 60/439 (13%)

Query: 145 EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQW 204
           +E     K L ++ EQ       T E+ K+   +E+ K++L +         +T    Q 
Sbjct: 358 QERDSQIKMLTEQVEQY------TKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411

Query: 205 MLKIARQLRVEKEREEYLAQQKQEQKN-QLFHAVQRLQRVQNQLKSMRQAAADAKPESLM 263
            L I ++   E ER   LA+    +K+ +L  A++RL+  ++ +  +  A  +      +
Sbjct: 412 TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVE------I 465

Query: 264 KRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINE-INTE 322
           K  + +IK                + +E+  L K +++  +  SD L+    + E +  E
Sbjct: 466 KNCKNQIKI---------------RDREIEILTKEINKLELKISDFLDENEALRERVGLE 510

Query: 323 INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382
              +I+    RN     K   YR +  I+ ++ E+  EE  + K+K+  + +E   KR+ 
Sbjct: 511 PKTMIDLTEFRNSK-HLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERG-KRSA 568

Query: 383 TREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF---GLLQRTEELLKQRH 439
           T      ++   +   +       K  +   K+   A+ K EF    L+++  +L + R 
Sbjct: 569 TSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRT 628

Query: 440 --ENIQQQLQTM-EEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSL 496
                Q +L+ + EE K +      +E L+ +  ++ + D   G T    S ++  L  L
Sbjct: 629 VIAKFQNKLKELVEENKQLE--EGMKEILQAIKEMQKDPDVKGGET----SLIIPSLERL 682

Query: 497 VSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREE 556
           V+  +S  A  I +                  K+Q D     L     +L QE+R  R+E
Sbjct: 683 VNAIESKNAEGIFDASL-------------HLKAQVDQ----LTGRNEELRQELRESRKE 725

Query: 557 CLQEESRYHYTNCMIKNLE 575
            +    +    N  I +LE
Sbjct: 726 AINYSQQLAKANLKIDHLE 744



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 102/566 (18%), Positives = 236/566 (41%), Gaps = 83/566 (14%)

Query: 141  NKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVET-A 199
            NKQY EL   ++ + ++   L     +   +  +  +++E+ + + K +E  K+++ T  
Sbjct: 966  NKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIE 1025

Query: 200  QNHQWMLKIARQLRVEKEREE--------------YLAQQKQEQKNQLFHAVQRLQRVQN 245
            Q  +   K+  +  ++K ++                L  ++  ++ +  H  +  + ++ 
Sbjct: 1026 QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRT 1085

Query: 246  QLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMG 305
             LK M +     +   L  +  E  K NL    +K  + L ++  +   + K VS+    
Sbjct: 1086 SLKQMEE-----RNFELETKFAELTKINL--DAQKVEQMLRDELAD--SVSKAVSD--AD 1134

Query: 306  HSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEA 365
               +LELE    E+  E+++L E              + R+Q  I++ +++++ +E++  
Sbjct: 1135 RQRILELEKNEMELKVEVSKLREIS-----------DIARRQVEILNAQQQSRDKEVESL 1183

Query: 366  KEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425
            + +L   + ++  K    +       L+  E    + KL S ++  +K       L+ + 
Sbjct: 1184 RMQLLDYQAQSDEKSLIAKLHQHNVSLQLSE-ATALGKLESITSKLQKMEAYNLRLEQK- 1241

Query: 426  GLLQRTEELL-------KQRHENIQQQLQTM------------EEKKGISGYSYTQEELE 466
              L   E+ L       + R ++++Q +Q++            +EK   +      ++L+
Sbjct: 1242 --LDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLK 1299

Query: 467  RVSALKSEVDE---MKGRTLDDMSEMVKKLYSLVSEKKSALAS--VIK---ELRQLRQKY 518
             +  +K+   E   M+ +TL +M   +K L  L+S  K    +  VI    ++ +LR + 
Sbjct: 1300 IMQEMKNSQQEHRNMENKTL-EMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQE 1358

Query: 519  QELTQEC--DEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEV 576
             +L +E   D+++ +Y      L +  S+ E+ +  L EE +Q+   +          EV
Sbjct: 1359 LKLNRELVKDKEEIKY------LNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREV 1412

Query: 577  QLRRATD----EMKAYISSDQ--QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHG 630
             L R  D    +    +++ Q  +E   +I +       + E   +K++E  ++I E+  
Sbjct: 1413 DLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRA 1472

Query: 631  PNMKQAKMWRDLEQLMECKKQCFLKQ 656
                  +  ++ E  +   +Q  L +
Sbjct: 1473 TCKSLEEKLKEKESALRLAEQNILSR 1498


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 123/584 (21%), Positives = 252/584 (43%), Gaps = 65/584 (11%)

Query: 126 EVPSEFLQ--DETVADTNKQYEELMEAFKTLHKEYE---------QLKISGFSTAEIRKD 174
           +VPS   Q  D T+ D   Q +EL      L KE +            I  F + E++K+
Sbjct: 134 QVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKE 193

Query: 175 ISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIAR-QLRVEKEREEYLAQQKQEQKNQL 233
               +EE  ++    E ++   E  Q+ Q  ++  + +LR +++   +L QQ+   +   
Sbjct: 194 RVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLN-HLLQQESGNRGAE 252

Query: 234 FHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELH 293
              ++  +  +N  +   +    AK   L+++  EE++  +    +      E+ KK L 
Sbjct: 253 HFTIELTE--ENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE 310

Query: 294 FLQ------KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQ 347
            LQ      K + +       + E ES+++ +   ++Q  ++ +   E +  +  L  + 
Sbjct: 311 MLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEP 370

Query: 348 ASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKL--- 404
           A     K +A    ++    K+ASLER      ++ +      VL  ++ +  + ++   
Sbjct: 371 A-----KTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 425

Query: 405 RSKSTVFKKK----HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSY 460
           +S S   K K     Q +++ ++E   LQ   E L  ++ + +Q ++ ++E       S 
Sbjct: 426 KSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKE-------SL 478

Query: 461 TQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSL--VSEKKSALASVIKELRQ----- 513
           T +E +R + L++EVD ++ R  +  S + KK   L  ++E+K  LA  I++++      
Sbjct: 479 TAKE-QRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVK 537

Query: 514 ------LRQKYQELTQECDEKKSQYDSC---AAGLESNRSKLEQEVRRLREECLQEESRY 564
                 L++K + L ++  +K  Q  +       L+++ S  +  +  L EE L E+ R 
Sbjct: 538 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATL-EEALSEKER- 595

Query: 565 HYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKV 624
                +I+ L+ Q  R   E    I S ++E  K ++E+     AE       L + ++ 
Sbjct: 596 -----IIERLKEQRERDDRERLEEIESFRKE-NKDLKEKVNALQAELTEKESSLIDLKEH 649

Query: 625 IRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQE 668
                   +K+    + LE  +E KK+   K ++Q      I++
Sbjct: 650 ASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIED 693


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 121/548 (22%), Positives = 236/548 (43%), Gaps = 59/548 (10%)

Query: 146  ELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWM 205
            E  +A K    E E+L++       ++++ +   E +++L K   H  + +   +N    
Sbjct: 1159 ESEKAIKEKEYEIERLRVL------LQEEGTRKREYENELAKVRNHYNEEMSNLRN---- 1208

Query: 206  LKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKR 265
             K   ++ + K   + ++ QK++    L + + RL R    LK       D    S+++ 
Sbjct: 1209 -KYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLND----SILQA 1263

Query: 266  LEEEIKFNLYMVTEKF-PKELENKKKELHFLQKVV----SEPAMGHSDLLELESK-INEI 319
             E+  +     + +K    E+  KK+ L    K V    SE    H   LE  +K I + 
Sbjct: 1264 TEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDK 1323

Query: 320  NTEINQL---IEKKMMRNEPIEGKLSLYRQQ--ASIISRKKEAKAEELQEAKEKLASL-- 372
            N EI +L    +++  R    E +LS  R      IIS K + + E +   K  +  L  
Sbjct: 1324 NKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETE-INITKTTIHQLTM 1382

Query: 373  --EREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQR 430
              E + S  R Q            +E KR  N L   +   ++  + I + KA    + +
Sbjct: 1383 QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQ 1442

Query: 431  TEELLKQRHENIQQQL--QTMEEKKGISGYSYT-QEELERVSALKSEVDEMKG--RTLDD 485
             ++ L+     + Q    +++  K+ +   + T Q++ + +  LK  +D+     + L+D
Sbjct: 1443 RKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLED 1502

Query: 486  MSEMVKKL-YSLVSEKKSALASVIK------ELRQLRQKYQELTQEC---DEKKSQYDSC 535
             +  ++++ Y L     SA  ++ K      EL +LR  Y+ ++QE    D+  +++ + 
Sbjct: 1503 ENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNS 1562

Query: 536  AAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQL---RRATDEMKAYISS- 591
               L+  + K+E+E+ RL+    ++       +C  K LE +L   RR+  E    I++ 
Sbjct: 1563 LKELQLQKQKVEEELNRLKRTASED-------SCKRKKLEEELEGMRRSLKEQAIKITNL 1615

Query: 592  -DQQEKRKAIREQYTKNTAEQEN-LGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECK 649
              Q E+   ++++   +  +Q + L   LREKQ+   E    + +   + R L Q  E  
Sbjct: 1616 TQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESV 1675

Query: 650  KQCFLKQQ 657
            KQ  L+ +
Sbjct: 1676 KQAHLRNE 1683



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 113/524 (21%), Positives = 235/524 (44%), Gaps = 51/524 (9%)

Query: 124  KLEVPSEFLQDETVADTNKQYEELMEAFKTL---HKEYEQLKISGFSTAEIRKDISAMEE 180
            +LEV    +      ++ +  + L +A KT+   +KE E+LK         RK +    E
Sbjct: 1446 QLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL----E 1501

Query: 181  EKDQLIKRVEH-LKKRVETAQNHQWMLKIARQ----LRVEKEREEYLAQQKQEQKNQLFH 235
            +++  ++RV++ L+K   +A      LK+  Q    LR++ ER       K +   +  +
Sbjct: 1502 DENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQN 1561

Query: 236  AVQRLQ----RVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK--ELENKK 289
            +++ LQ    +V+ +L  +++ A++   +   K+LEEE++     + E+  K   L  + 
Sbjct: 1562 SLKELQLQKQKVEEELNRLKRTASEDSCKR--KKLEEELEGMRRSLKEQAIKITNLTQQL 1619

Query: 290  KELHFLQKVVSEPAMGHSDLLE--------LESKINEINTEINQLIEKKMMRNEPIEGKL 341
            ++   ++K   +      D+L+         + ++  +++E+  L  + +   E +  K 
Sbjct: 1620 EQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESV--KQ 1677

Query: 342  SLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYV 401
            +  R +     +  E K+  L E+K     +ER  S+  N T+E    E    +    Y 
Sbjct: 1678 AHLRNEH--FQKAIEDKSRSLNESK---IEIERLQSLTENLTKEHLMLEEELRNLRLEYD 1732

Query: 402  NKLRSKSTVFKKKHQIIAELKAEFGLLQ-RTEEL------LKQRHENIQQQLQTMEEKKG 454
            +  R +S     K+  I EL+++  +   RT EL      L++  EN++Q+++  + K+ 
Sbjct: 1733 DLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQ-KQA 1791

Query: 455  ISGYSYTQEELERVSALKSEVDEM--KGRTLDDMSEMVKKLYSLVSEKKSALASVIKELR 512
            +   +  QE   + + +  E + +  K + L+     +++L   ++  KS L +  +  +
Sbjct: 1792 LEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQ 1851

Query: 513  QLRQKYQELTQECDEKKSQY---DSCAAGLESNRSKLEQEVRRLREEC--LQEESRYHYT 567
            +L  + Q++  + ++ K+QY   +     +ES R K E+E   LR E   LQ E +    
Sbjct: 1852 RLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEE 1911

Query: 568  NCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQ 611
             C  + LE   R    +++   S  Q+E  K  +  Y  +   Q
Sbjct: 1912 RCR-RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1954



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 110/566 (19%), Positives = 232/566 (40%), Gaps = 66/566 (11%)

Query: 150  AFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIA 209
            A + L K Y Q+K       E+ + I+ +  E +   +R + ++ R +  +N    L+ A
Sbjct: 1093 AKQNLDKCYGQIK-------ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA 1145

Query: 210  RQLRVE-----KEREEYLAQQKQEQKNQLFHAVQ----RLQRVQNQLKSMRQAAADAKPE 260
            RQ   E     K   E   ++K+ +  +L   +Q    R +  +N+L  +R    + +  
Sbjct: 1146 RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNE-EMS 1204

Query: 261  SLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEIN 320
            +L  + E EI      + E   ++ ++ K   + L ++  E      +++ L   I +  
Sbjct: 1205 NLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQA- 1263

Query: 321  TEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKR 380
            TE  +  E+  ++ +    ++   +Q   I    K+   +  ++      SLE  A   +
Sbjct: 1264 TEQRRRAEENALQQKACGSEIMQKKQHLEI--ELKQVMQQRSEDNARHKQSLEEAAKTIQ 1321

Query: 381  NQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHE 440
            ++ +E +  +    +E KR        S V     + I  LK +F      E  +     
Sbjct: 1322 DKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQF------ETEINITKT 1375

Query: 441  NIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEK 500
             I Q   TM++++  SGY    + L R +   SE  +    TL   +E ++++   + ++
Sbjct: 1376 TIHQL--TMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQ 1433

Query: 501  KSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLRE----- 555
            K+  + V +  +QL  + +++TQ   E+  +Y               +E+ RL++     
Sbjct: 1434 KATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKE 1493

Query: 556  ----ECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYIS--SDQQEKRKAIREQYTKNTA 609
                +CL++E      N  ++ ++  L++A       I+    Q+++   +R  Y + + 
Sbjct: 1494 TNDRKCLEDE------NARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547

Query: 610  E-----------QENLGKKLREKQKVIRE-------SHGPNMKQAKMWRDLEQLMECKKQ 651
            E           Q +L +   +KQKV  E       +   + K+ K+  +LE +    K+
Sbjct: 1548 ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE 1607

Query: 652  CFLK---QQSQTSIGQVIQEGGEDRL 674
              +K      Q     ++++  ED L
Sbjct: 1608 QAIKITNLTQQLEQASIVKKRSEDDL 1633



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 77/379 (20%), Positives = 162/379 (42%), Gaps = 47/379 (12%)

Query: 112  LKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEI 171
            LK++A     L +    +  ++  +  D  +Q + L    +   +  E+L+        +
Sbjct: 1605 LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEAL 1664

Query: 172  RKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKN 231
            R+ +   +E   Q   R EH +K +E         +   + ++E ER + L +   ++  
Sbjct: 1665 RRQLLQEQESVKQAHLRNEHFQKAIEDKS------RSLNESKIEIERLQSLTENLTKEHL 1718

Query: 232  QLFHAVQRLQRVQNQLKSMRQAAADAKPESLMK-RLEEEIKFN----LYMVTEKFPKELE 286
             L   ++ L+   + L+  R  A   K  ++++ R + +I  N    L  +     +E E
Sbjct: 1719 MLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERE 1778

Query: 287  NKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQ 346
            N ++E+   QK            LE  ++I E   +  Q+++++    E +  K+ +  Q
Sbjct: 1779 NLRQEIEKFQK----------QALEASNRIQESKNQCTQVVQER----ESLLVKIKVLEQ 1824

Query: 347  QASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRS 406
              + + R +    +EL  AK   ++LE E  VK+               E ++  N L  
Sbjct: 1825 DKARLQRLE----DELNRAK---STLEAETRVKQRLE-----------CEKQQIQNDLNQ 1866

Query: 407  KSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEE---KKGISGYSYTQE 463
              T + +K + I ++++E    +R +  L+   E +Q +++ +EE   +K       TQ 
Sbjct: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926

Query: 464  ELE-RVSALKSEVDEMKGR 481
            +LE   S  + E+D+++ R
Sbjct: 1927 QLETERSRYQREIDKLRQR 1945



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 54/276 (19%), Positives = 114/276 (41%), Gaps = 30/276 (10%)

Query: 418 IAELKAEFGLLQRTEELLKQRHENIQ--QQLQTMEEKKGISGYSYTQEELERVSALKSEV 475
           + E  A + L +  E LLK   E +   +QLQ + +         T  E+  ++  + E 
Sbjct: 242 LREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQA--------TSREIMWINDCEEE- 292

Query: 476 DEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSC 535
            E+     D  + + +K  +  S + S L    KEL +L+Q+  +L         + ++ 
Sbjct: 293 -ELLYDWSDKNTNIAQKQEAF-SIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAY 350

Query: 536 AAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE 595
              L++  S + Q + +  +  L+E + Y       ++ E  L+   D ++     D+  
Sbjct: 351 MDTLQTQWSWILQ-ITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNM 409

Query: 596 KRKAIREQYTKNTAEQENLGKKLREKQKVIRES--------HGPNMKQAKM--------W 639
             + + EQ  +   E+E + +  R+ Q ++ +S          P+ +  K         +
Sbjct: 410 PLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDY 469

Query: 640 RDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDRLI 675
           +  ++++    +C LK  ++ S   V   GG D L+
Sbjct: 470 KQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLV 505


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 110/537 (20%), Positives = 228/537 (42%), Gaps = 71/537 (13%)

Query: 168  TAEIRKDISAMEEE----KDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLA 223
            +AE  K+++ M+EE    KD+L K      KR E  +    +LK    L+++ + E    
Sbjct: 848  SAETEKEMATMKEEFQKIKDELAKSEA---KRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 224  QQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283
               +E+ +QL     +L+    ++K + + A D          EEEI   L     K   
Sbjct: 905  ADAEERCDQLIKTKIQLEA---KIKEVTERAED----------EEEINAELTAKKRKLED 951

Query: 284  ELENKKKELHFLQ----KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEG 339
            E    KK++  L+    KV  E     + +  L  ++  ++  I +L ++K    E  + 
Sbjct: 952  ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011

Query: 340  KLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVK---RNQTREFDGTEVLKGDE 396
             L   + +   ++   +AK +  Q+  +   SLE+E  ++       R+ +G   L  + 
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071

Query: 397  FKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGIS 456
                 N+ +      KKK   I+ L+++    Q     L+++ + +Q +++ +EE     
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE----- 1126

Query: 457  GYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQ 516
                 + E ER S  K+E      +   D+S  ++++   + E   A ++ I+  ++   
Sbjct: 1127 -----EIEAERASRAKAE------KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175

Query: 517  KYQELTQECDEKKSQYDSCAA------------------GLESNRSKLEQEVRRLREECL 558
            ++Q++ ++ +E   Q+++ AA                   L+  + KLE+E   ++ E  
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235

Query: 559  QEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKR--KAIREQYTKNTAEQENLGK 616
               S     +    NLE   R   D++    S +++++R    +  Q  +   E     +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295

Query: 617  KLREKQKVIRE-SHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGED 672
            +L EK+ ++ + S G   KQA      +Q+ E K+Q   + +++ ++   +Q    D
Sbjct: 1296 QLDEKEALVSQLSRG---KQA----FTQQIEELKRQLEEEIKAKNALAHALQSSRHD 1345



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 137/559 (24%), Positives = 243/559 (43%), Gaps = 60/559 (10%)

Query: 111  ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYE----QLKISGF 166
            E K R  L R   KLE   +  Q E++ D   + ++L E  K   KE+E    Q KI   
Sbjct: 1047 EKKLRMDLERAKRKLEGDLKLAQ-ESIMDIENEKQQLDEKLKK--KEFEISNLQSKIEDE 1103

Query: 167  STA--EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYL-- 222
                 +++K I  ++   ++L + +E   +R   A+  +    ++R+L    ER E    
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIE--AERASRAKAEKQRSDLSRELEEISERLEEAGG 1161

Query: 223  AQQKQEQKNQLFHA-VQRLQRVQNQLKSMRQAAADA---KPESLMKRLEEEIKFNLYMVT 278
            A   Q + N+   A  Q+++R   +     +A A     K    +  L E+I  NL  V 
Sbjct: 1162 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID-NLQRVK 1220

Query: 279  EKFPKELENKKKELHFLQKVVS--EPAMGHSD---------LLELESKINEINTEINQLI 327
            +K  KE    K E+  L   V     A G+ +         L EL+SK  E    IN L 
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280

Query: 328  EKK-MMRNEPIEGKLSLYRQQASI--ISRKKEAKAEELQEAKEKLASLEREASVKRNQTR 384
             ++  ++ E  E    L  ++A +  +SR K+A  ++++E K +L   E E   K     
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL---EEEIKAKNALAH 1337

Query: 385  EFDGT----EVLKGDEFKRYVNKLRSKSTVFKKKHQIIA-ELKAEFGLLQRTEELLKQRH 439
                +    ++L+    +   +K   +  + K   ++     K E   +QRTEEL ++  
Sbjct: 1338 ALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL-EEAK 1396

Query: 440  ENIQQQLQTMEEKKGISGYSYTQEELERVSA-LKSEVDEMK---GRTLDDMSEMVKKLYS 495
            + + Q+LQ  EE   +   +     LE+    L++EV+++     RT    + + KK  +
Sbjct: 1397 KKLAQRLQAAEEH--VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN 1454

Query: 496  ---LVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLES---NRSKLEQE 549
               +++E K        EL   +++ + L  E  + K+ Y+     LE+       L+QE
Sbjct: 1455 FDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQE 1514

Query: 550  VRRLREECLQEESRYHYTNCMIKNLE---VQLRRATDEMKAYISSDQQEKRKAIREQYTK 606
            +  L E+  +   R H    + K +E    +L+ A +E +A   S + E+ K +R Q   
Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571

Query: 607  NTAEQENLGKKLREKQKVI 625
            N  + E + +K+ EK + I
Sbjct: 1572 NQVKSE-VDRKIAEKDEEI 1589



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 94/468 (20%), Positives = 195/468 (41%), Gaps = 62/468 (13%)

Query: 144  YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQ 203
            YEE ++  +TL +E + L+          ++IS + E+  +  KR+  L+K  +  +  +
Sbjct: 1494 YEESLDQLETLKRENKNLQ----------QEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1543

Query: 204  WMLKIA-RQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESL 262
              L+ A  +     E EE    + Q + NQ+   V R    +++     +       ES+
Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603

Query: 263  MKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTE 322
               L+ EI+     +  K  K++E    E+        E  + H++ +  E+  N  NT+
Sbjct: 1604 QSTLDAEIRSRNDAIRLK--KKMEGDLNEM--------EIQLNHANRMAAEALRNYRNTQ 1653

Query: 323  INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382
               L + ++  ++ +  +  L ++Q +++ R+      E++E +  L   ER        
Sbjct: 1654 -GILKDTQIHLDDALRSQEDL-KEQLAMVERRANLLQAEIEELRATLEQTER-------- 1703

Query: 383  TREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQI-IAELKAEF-GLLQRTEELLKQRHE 440
            +R+    E+L   E  + ++   +     KKK +  I++++ E   +LQ      ++  +
Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763

Query: 441  NIQQQLQTMEEKKGISGYSYTQEELER-----VSALKSEVDEMKGRTLDDMSEMVKKLYS 495
             I       EE K     S   E +++     V  L+  +DE +   L    + ++KL +
Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823

Query: 496  LVSEKKSAL-------ASVIKELRQLRQKYQELTQECDEKKSQY-------DSCAAGLES 541
             V E +  +       A  +K LR+  ++ +ELT + +E +          D   A ++S
Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1883

Query: 542  NRSKLEQ----------EVRRLREECLQEESRYHYTNCMIKNLEVQLR 579
             + + E+          + R+L+ E  + E R       +  L V+ R
Sbjct: 1884 YKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSR 1931



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 69/312 (22%), Positives = 146/312 (46%), Gaps = 33/312 (10%)

Query: 368  KLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS-TVFKKKHQIIAELKAEFG 426
            K A  E+E +  + + ++    + L   E KR   +L  K  T+ K+K+ +  +++AE  
Sbjct: 847  KSAETEKEMATMKEEFQKIK--DELAKSEAKR--KELEEKMVTLLKEKNDLQLQVQAEAE 902

Query: 427  LL----QRTEELLK---QRHENIQQQLQTMEEKKGISG-YSYTQEELE-RVSALKSEVDE 477
             L    +R ++L+K   Q    I++  +  E+++ I+   +  + +LE   S LK ++D+
Sbjct: 903  GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962

Query: 478  MKGRTLDDMSE-------MVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS 530
            ++  TL  + +        VK L   ++     +A + KE + L++ +Q+   +   ++ 
Sbjct: 963  LE-LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021

Query: 531  QYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYIS 590
            + ++    L   + KLEQ+V  L     QE+          + LE  L+ A + +     
Sbjct: 1022 KVNT----LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI----- 1072

Query: 591  SDQQEKRKAIREQYTKNTAEQENLGKKLREKQKV-IRESHGPNMKQAKMWRDLEQLMECK 649
             D + +++ + E+  K   E  NL  K+ ++Q + I+        QA++  +LE+ +E +
Sbjct: 1073 MDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI-EELEEEIEAE 1131

Query: 650  KQCFLKQQSQTS 661
            +    K + Q S
Sbjct: 1132 RASRAKAEKQRS 1143



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 5/111 (4%)

Query: 124  KLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183
            KLE     L+ E  ++  +      EA K L K   ++K   + T E RK+I  +++  D
Sbjct: 1820 KLEARVRELEGEVESEQKRN----AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1875

Query: 184  QLIKRVEHLKKRVETAQNH-QWMLKIARQLRVEKEREEYLAQQKQEQKNQL 233
            +L  +V+  K++ E A+      L   R+L+ E E  E  A   + Q N+L
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 46/244 (18%), Positives = 106/244 (43%), Gaps = 24/244 (9%)

Query: 145  EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQW 204
            +EL++A + +   + Q      +  ++  DIS M+ E + +++   + +++ + A     
Sbjct: 1710 QELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAA 1769

Query: 205  MLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN-QLKSMRQAAA--DAKPES 261
            M+  A +L+ E++   +L + K+  +  +     RL   +   LK  ++     +A+   
Sbjct: 1770 MM--AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1827

Query: 262  LMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINT 321
            L   +E E K N   V  K  ++ E + KEL +      +      ++L L+  ++++  
Sbjct: 1828 LEGEVESEQKRNAEAV--KGLRKHERRVKELTY------QTEEDRKNILRLQDLVDKLQA 1879

Query: 322  EINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRN 381
            ++     +     E     L+ +R+              EL+EA+E+    E + +  R 
Sbjct: 1880 KVKSYKRQAEEAEEQSNTNLAKFRKLQ-----------HELEEAEERADIAESQVNKLRV 1928

Query: 382  QTRE 385
            ++RE
Sbjct: 1929 KSRE 1932


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 110/537 (20%), Positives = 228/537 (42%), Gaps = 71/537 (13%)

Query: 168  TAEIRKDISAMEEE----KDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLA 223
            +AE  K+++ M+EE    KD+L K      KR E  +    +LK    L+++ + E    
Sbjct: 848  SAETEKEMATMKEEFQKIKDELAKSEA---KRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 224  QQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283
               +E+ +QL     +L+    ++K + + A D          EEEI   L     K   
Sbjct: 905  ADAEERCDQLIKTKIQLEA---KIKEVTERAED----------EEEINAELTAKKRKLED 951

Query: 284  ELENKKKELHFLQ----KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEG 339
            E    KK++  L+    KV  E     + +  L  ++  ++  I +L ++K    E  + 
Sbjct: 952  ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011

Query: 340  KLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVK---RNQTREFDGTEVLKGDE 396
             L   + +   ++   +AK +  Q+  +   SLE+E  ++       R+ +G   L  + 
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071

Query: 397  FKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGIS 456
                 N+ +      KKK   I+ L+++    Q     L+++ + +Q +++ +EE     
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE----- 1126

Query: 457  GYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQ 516
                 + E ER S  K+E      +   D+S  ++++   + E   A ++ I+  ++   
Sbjct: 1127 -----EIEAERASRAKAE------KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175

Query: 517  KYQELTQECDEKKSQYDSCAA------------------GLESNRSKLEQEVRRLREECL 558
            ++Q++ ++ +E   Q+++ AA                   L+  + KLE+E   ++ E  
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235

Query: 559  QEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKR--KAIREQYTKNTAEQENLGK 616
               S     +    NLE   R   D++    S +++++R    +  Q  +   E     +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295

Query: 617  KLREKQKVIRE-SHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGED 672
            +L EK+ ++ + S G   KQA      +Q+ E K+Q   + +++ ++   +Q    D
Sbjct: 1296 QLDEKEALVSQLSRG---KQA----FTQQIEELKRQLEEEIKAKNALAHALQSSRHD 1345



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 137/559 (24%), Positives = 243/559 (43%), Gaps = 60/559 (10%)

Query: 111  ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYE----QLKISGF 166
            E K R  L R   KLE   +  Q E++ D   + ++L E  K   KE+E    Q KI   
Sbjct: 1047 EKKLRMDLERAKRKLEGDLKLAQ-ESIMDIENEKQQLDEKLKK--KEFEISNLQSKIEDE 1103

Query: 167  STA--EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYL-- 222
                 +++K I  ++   ++L + +E   +R   A+  +    ++R+L    ER E    
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIE--AERASRAKAEKQRSDLSRELEEISERLEEAGG 1161

Query: 223  AQQKQEQKNQLFHA-VQRLQRVQNQLKSMRQAAADA---KPESLMKRLEEEIKFNLYMVT 278
            A   Q + N+   A  Q+++R   +     +A A     K    +  L E+I  NL  V 
Sbjct: 1162 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID-NLQRVK 1220

Query: 279  EKFPKELENKKKELHFLQKVVS--EPAMGHSD---------LLELESKINEINTEINQLI 327
            +K  KE    K E+  L   V     A G+ +         L EL+SK  E    IN L 
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280

Query: 328  EKK-MMRNEPIEGKLSLYRQQASI--ISRKKEAKAEELQEAKEKLASLEREASVKRNQTR 384
             ++  ++ E  E    L  ++A +  +SR K+A  ++++E K +L   E E   K     
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL---EEEIKAKNALAH 1337

Query: 385  EFDGT----EVLKGDEFKRYVNKLRSKSTVFKKKHQIIA-ELKAEFGLLQRTEELLKQRH 439
                +    ++L+    +   +K   +  + K   ++     K E   +QRTEEL ++  
Sbjct: 1338 ALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL-EEAK 1396

Query: 440  ENIQQQLQTMEEKKGISGYSYTQEELERVSA-LKSEVDEMK---GRTLDDMSEMVKKLYS 495
            + + Q+LQ  EE   +   +     LE+    L++EV+++     RT    + + KK  +
Sbjct: 1397 KKLAQRLQAAEEH--VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN 1454

Query: 496  ---LVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLES---NRSKLEQE 549
               +++E K        EL   +++ + L  E  + K+ Y+     LE+       L+QE
Sbjct: 1455 FDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQE 1514

Query: 550  VRRLREECLQEESRYHYTNCMIKNLE---VQLRRATDEMKAYISSDQQEKRKAIREQYTK 606
            +  L E+  +   R H    + K +E    +L+ A +E +A   S + E+ K +R Q   
Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571

Query: 607  NTAEQENLGKKLREKQKVI 625
            N  + E + +K+ EK + I
Sbjct: 1572 NQVKSE-VDRKIAEKDEEI 1589



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 94/468 (20%), Positives = 195/468 (41%), Gaps = 62/468 (13%)

Query: 144  YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQ 203
            YEE ++  +TL +E + L+          ++IS + E+  +  KR+  L+K  +  +  +
Sbjct: 1494 YEESLDQLETLKRENKNLQ----------QEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1543

Query: 204  WMLKIA-RQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESL 262
              L+ A  +     E EE    + Q + NQ+   V R    +++     +       ES+
Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603

Query: 263  MKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTE 322
               L+ EI+     +  K  K++E    E+        E  + H++ +  E+  N  NT+
Sbjct: 1604 QSTLDAEIRSRNDAIRLK--KKMEGDLNEM--------EIQLNHANRMAAEALRNYRNTQ 1653

Query: 323  INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382
               L + ++  ++ +  +  L ++Q +++ R+      E++E +  L   ER        
Sbjct: 1654 -GILKDTQIHLDDALRSQEDL-KEQLAMVERRANLLQAEIEELRATLEQTER-------- 1703

Query: 383  TREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQI-IAELKAEF-GLLQRTEELLKQRHE 440
            +R+    E+L   E  + ++   +     KKK +  I++++ E   +LQ      ++  +
Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763

Query: 441  NIQQQLQTMEEKKGISGYSYTQEELER-----VSALKSEVDEMKGRTLDDMSEMVKKLYS 495
             I       EE K     S   E +++     V  L+  +DE +   L    + ++KL +
Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823

Query: 496  LVSEKKSAL-------ASVIKELRQLRQKYQELTQECDEKKSQY-------DSCAAGLES 541
             V E +  +       A  +K LR+  ++ +ELT + +E +          D   A ++S
Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1883

Query: 542  NRSKLEQ----------EVRRLREECLQEESRYHYTNCMIKNLEVQLR 579
             + + E+          + R+L+ E  + E R       +  L V+ R
Sbjct: 1884 YKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSR 1931



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 69/312 (22%), Positives = 146/312 (46%), Gaps = 33/312 (10%)

Query: 368  KLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS-TVFKKKHQIIAELKAEFG 426
            K A  E+E +  + + ++    + L   E KR   +L  K  T+ K+K+ +  +++AE  
Sbjct: 847  KSAETEKEMATMKEEFQKIK--DELAKSEAKR--KELEEKMVTLLKEKNDLQLQVQAEAE 902

Query: 427  LL----QRTEELLK---QRHENIQQQLQTMEEKKGISG-YSYTQEELE-RVSALKSEVDE 477
             L    +R ++L+K   Q    I++  +  E+++ I+   +  + +LE   S LK ++D+
Sbjct: 903  GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962

Query: 478  MKGRTLDDMSE-------MVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS 530
            ++  TL  + +        VK L   ++     +A + KE + L++ +Q+   +   ++ 
Sbjct: 963  LE-LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021

Query: 531  QYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYIS 590
            + ++    L   + KLEQ+V  L     QE+          + LE  L+ A + +     
Sbjct: 1022 KVNT----LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI----- 1072

Query: 591  SDQQEKRKAIREQYTKNTAEQENLGKKLREKQKV-IRESHGPNMKQAKMWRDLEQLMECK 649
             D + +++ + E+  K   E  NL  K+ ++Q + I+        QA++  +LE+ +E +
Sbjct: 1073 MDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI-EELEEEIEAE 1131

Query: 650  KQCFLKQQSQTS 661
            +    K + Q S
Sbjct: 1132 RASRAKAEKQRS 1143



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 5/111 (4%)

Query: 124  KLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183
            KLE     L+ E  ++  +      EA K L K   ++K   + T E RK+I  +++  D
Sbjct: 1820 KLEARVRELEGEVESEQKRN----AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1875

Query: 184  QLIKRVEHLKKRVETAQNH-QWMLKIARQLRVEKEREEYLAQQKQEQKNQL 233
            +L  +V+  K++ E A+      L   R+L+ E E  E  A   + Q N+L
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 46/244 (18%), Positives = 106/244 (43%), Gaps = 24/244 (9%)

Query: 145  EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQW 204
            +EL++A + +   + Q      +  ++  DIS M+ E + +++   + +++ + A     
Sbjct: 1710 QELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAA 1769

Query: 205  MLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN-QLKSMRQAAA--DAKPES 261
            M+  A +L+ E++   +L + K+  +  +     RL   +   LK  ++     +A+   
Sbjct: 1770 MM--AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1827

Query: 262  LMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINT 321
            L   +E E K N   V  K  ++ E + KEL +      +      ++L L+  ++++  
Sbjct: 1828 LEGEVESEQKRNAEAV--KGLRKHERRVKELTY------QTEEDRKNILRLQDLVDKLQA 1879

Query: 322  EINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRN 381
            ++     +     E     L+ +R+              EL+EA+E+    E + +  R 
Sbjct: 1880 KVKSYKRQAEEAEEQSNTNLAKFRKLQ-----------HELEEAEERADIAESQVNKLRV 1928

Query: 382  QTRE 385
            ++RE
Sbjct: 1929 KSRE 1932


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 100/525 (19%), Positives = 237/525 (45%), Gaps = 62/525 (11%)

Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQ------------NH--QWMLKIARQLRV 214
           A++++ +  +E EK ++   V+ LK+++E A+            +H  + +  ++ +L+ 
Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 283

Query: 215 EKEREEYLAQQKQEQKNQLFHAVQRLQ----RVQNQLKSMRQAAADAKPESLMKRLEEEI 270
           + E  E   +  Q+Q+ +++   +++Q    ++Q Q + +R+     + +    R +EE+
Sbjct: 284 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343

Query: 271 KFNLYMVTEKFPKELENKKKELHFLQKVV--SEPAMGHSD--LLELESKINEINTEINQL 326
            +       +  + +  K++++   ++++   E  M   +  + E E KI E+       
Sbjct: 344 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL------- 396

Query: 327 IEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREF 386
            E+KM   E I               R++E K +E ++ +E+    E+EA + R + +  
Sbjct: 397 -EEKMHEQEKI---------------REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 440

Query: 387 DGTEVLKGDEFK--RYVNKLRSKSTVFKK-KHQIIAELKAEFGLLQRTEELLKQRHENIQ 443
           +  E ++  E K  R   K+  +  + ++ K Q   E+  +   +   EE+ +Q+ +  +
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE 500

Query: 444 QQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMK----GRTLDDMSEMVKKLYSLVSE 499
           Q+ +  ++++ +    + QEE  R    K    E K       + +  EM ++   +  +
Sbjct: 501 QEEKIRKQEEKV----WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ 556

Query: 500 KKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQ 559
           +K       +E      + +E  +E +EK  + +      E  R + E+++ +  E+  +
Sbjct: 557 EKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIRE 616

Query: 560 EESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGK--- 616
           +E +       I+  E ++R   +EM         E+ + + EQ  K   ++E + +   
Sbjct: 617 QEEKIQEQEEKIREQEEKIREQ-EEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEE 675

Query: 617 KLREKQKVIRESHGPNMKQAKMWRDLEQLM--ECKKQCFLKQQSQ 659
           K+RE++K IRE      +Q +M ++ E+ M  + +K C  +++ Q
Sbjct: 676 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 720



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 95/466 (20%), Positives = 217/466 (46%), Gaps = 48/466 (10%)

Query: 197 ETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLF---HAVQRLQRVQNQLKSMRQA 253
           E   +HQ    + R+L  +      L  QK E +  L+   HAV++L+     L S    
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 169

Query: 254 A---ADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLL 310
           +   A    ++L     ++ K + Y+  E+  KE +    EL+  +  +++  +   +  
Sbjct: 170 SWKFAGELEQALSAVATQKKKADRYI--EELTKERDALSLELY--RNTITDEELKEKN-A 224

Query: 311 ELESKINEINTEINQL-IEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKL 369
           +L+ K+  + +E +++ +  K ++ +    KL L +QQ   +  + +   +ELQ    KL
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQ---LQAEADHLGKELQSVSAKL 281

Query: 370 ASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQ 429
            +   E  +     ++ +     + ++ + +  K++ +    +++ + I E + +   ++
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK---MR 338

Query: 430 RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEM 489
           R EE++ ++ E +++Q + M EK         +E++ R   +  E +E   R  + M E 
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEK---------EEKMRRQEEMMWEKEEKMRRQEEMMWEK 389

Query: 490 VKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQE 549
            +K+  L  E+K      I+E  + RQ+ +++ ++  EK+ + ++     E    + E++
Sbjct: 390 EEKIREL--EEKMHEQEKIREQEEKRQEEEKIREQ--EKRQEQEAKMWRQEEKIREQEEK 445

Query: 550 VRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEM-----KAYISSDQQEKRKAIREQY 604
           +R   ++  ++E + H      K  E + R+  +EM     K +   +   +++ + EQ 
Sbjct: 446 IREQEKKMWRQEEKIHEQE---KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQE 502

Query: 605 TKNTAEQENLGK---KLREKQKVIRESHGPNMKQAKMWRDLEQLME 647
            K   ++E + +   K+RE+++ IRE      ++ KMWR  E++ E
Sbjct: 503 EKIRKQEEKVWRQEEKIREQEEKIRE------QEEKMWRQEEKIRE 542



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 112/551 (20%), Positives = 242/551 (43%), Gaps = 62/551 (11%)

Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAE 170
           ELK++   A+ L+    P + LQ    A+ +   +EL      L  + E+         E
Sbjct: 246 ELKRKLERAKLLL----PQQQLQ----AEADHLGKELQSVSAKLQAQVEE--------NE 289

Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQK 230
           +   ++  +EEK         + ++ E  Q  +W  KI  Q    +E+EE + +Q+++ +
Sbjct: 290 LWNRLNQQQEEK---------MWRQEEKIQ--EWEEKIQEQEEKIREQEEKIREQEEKMR 338

Query: 231 NQLFHAVQRLQRVQNQLKSMRQAAADAK-PESLMKRLEEEIKFNLYMVTEKFPK--ELEN 287
            Q     ++ ++++ Q + M +     +  E +M   EE+++    M+ EK  K  ELE 
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 398

Query: 288 KKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPI-EGKLSLYRQ 346
           K  E   +++   E      + +  + K  E   ++ +  EK   + E I E +  ++RQ
Sbjct: 399 KMHEQEKIRE--QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 456

Query: 347 QASIISRKKEAKAEELQEAKEKLASLER---EASVKRNQTREFDGTEVLKGDEFK--RYV 401
           +  I  ++K  + E+ QE +E     E+   +  + R + +  +  E ++  E K  R  
Sbjct: 457 EEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQE 516

Query: 402 NKLRSKSTVFKKKHQII---AELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGY 458
            K+R +    +++ + +    E   E   + R EE + ++ +  +++ +  +E K     
Sbjct: 517 EKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE 576

Query: 459 SYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSL--VSEKKSALASVIKELRQLRQ 516
              +E+ E+V   + ++ E + +  +   +M K+   +    EK       I+E  +  +
Sbjct: 577 EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIR 636

Query: 517 KYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEV 576
           + +E+TQE +EK  + +      E    + E+ + R  E+  ++E +       I+  E 
Sbjct: 637 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKK-------IREQEE 689

Query: 577 QLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQA 636
           ++R   + M        QE+ + + EQ  K   ++E    K++E+++ +R       +Q 
Sbjct: 690 KIREQEEMM--------QEQEEKMWEQEEKMCEQEE----KMQEQEEKMRRQEEKMWEQE 737

Query: 637 KMWRDLEQLME 647
              R  E+ M+
Sbjct: 738 VRLRQQEEKMQ 748



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 101/534 (18%), Positives = 245/534 (45%), Gaps = 45/534 (8%)

Query: 149 EAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI 208
           EA   + + ++  K +G    E+ + +SA+  +K +  + +E L K  +        L++
Sbjct: 159 EARDLISRLHDSWKFAG----ELEQALSAVATQKKKADRYIEELTKERDALS-----LEL 209

Query: 209 ARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAK---PESLMKR 265
            R    ++E +E  A  K ++K QL  + +    +Q  +K +++    AK   P+  ++ 
Sbjct: 210 YRNTITDEELKEKNA--KLQEKLQLVESEK--SEIQLNVKELKRKLERAKLLLPQQQLQA 265

Query: 266 LEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQ 325
             + +   L  V+ K   ++E  +      Q+   +       + E E KI E   +I +
Sbjct: 266 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325

Query: 326 LIEKKMMRNEPIEGKLSLYRQQASIISRKKEA---KAEELQEAKEKLASLEREASVKRNQ 382
             EK   + E +  +  +  ++   + R++E    K E+++  +E +   E+E  ++R +
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM--WEKEEKMRRQE 383

Query: 383 TREFDGTEVLKGDEFKRYVN-KLRSKSTVFKKKHQIIAELKAEF--GLLQRTEELLKQRH 439
              ++  E ++  E K +   K+R +    +++ +I  + K +     + R EE ++++ 
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 443

Query: 440 ENIQQQLQTM-EEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVS 498
           E I++Q + M  +++ I      +EE +R    +    E K    +++    +K++    
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503

Query: 499 EKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECL 558
           + +     V ++  ++R++ +++ ++ ++   Q +      E  R   E+E    +E+  
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR---EEEKMHEQEKIW 560

Query: 559 QEESRYHYTNCM------IKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQE 612
           +EE R    + M      I+  E ++ R  ++++     +Q+EKR+   E+  K   +  
Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIR-----EQEEKRQEQEEKMWKQEEKIR 615

Query: 613 NLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLM------ECKKQCFLKQQSQT 660
              +K++E+++ IRE      +Q +M ++ E+ M       C+++  +++Q +T
Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEET 669



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 102/436 (23%), Positives = 194/436 (44%), Gaps = 61/436 (13%)

Query: 226 KQEQKNQLFHAVQRLQRVQNQLK-SMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKE 284
           K+ ++++L  A ++L     Q   S+  AA+D K + +      E        T      
Sbjct: 53  KETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPET------TTSGGCHS 106

Query: 285 LENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLY 344
            E+++K  H  Q+ +           ELE++++ I     Q  E +M           L 
Sbjct: 107 PEDEQKASHQHQEALRR---------ELEAQVHTIRILTCQKTELQMALYYSQHAVKQLE 157

Query: 345 RQQASIISRKKEAK--AEELQEAKEKLASLEREASVKRNQ-TREFDGTEVLKGDEFKRYV 401
            +   +ISR  ++   A EL++A   +A+ +++A     + T+E D   +   + ++  +
Sbjct: 158 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNTI 214

Query: 402 N--KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENI-----QQQLQTMEEKKG 454
              +L+ K+   ++K Q++   K+E   +Q   + LK++ E       QQQLQ   +  G
Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSE---IQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271

Query: 455 ISGYSYTQEELERVSA-LKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQ 513
                   +EL+ VSA L+++V+E         +E+  +L     EK       I+E  +
Sbjct: 272 --------KELQSVSAKLQAQVEE---------NELWNRLNQQQEEKMWRQEEKIQEWEE 314

Query: 514 LRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKN 573
             Q+ +E  +E +EK  + +      E    + E+++RR  E   ++E +      M+  
Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 374

Query: 574 LEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENL--GKKLREKQKVIRESHGP 631
            E ++RR  + M         EK + IRE   K   EQE +   ++ R++++ IRE    
Sbjct: 375 KEEKMRRQEEMM--------WEKEEKIRELEEK-MHEQEKIREQEEKRQEEEKIREQEKR 425

Query: 632 NMKQAKMWRDLEQLME 647
             ++AKMWR  E++ E
Sbjct: 426 QEQEAKMWRQEEKIRE 441



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 67/330 (20%), Positives = 144/330 (43%), Gaps = 43/330 (13%)

Query: 355 KEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK-LRSKSTVFKK 413
           KE +  +L EAKE+L            QT    GT     D  K+ +N     ++T    
Sbjct: 53  KETRQSKLAEAKEQLTD-------HHPQTNPSVGTAA--SDTKKKKINNGTNPETTTSGG 103

Query: 414 KHQIIAELKAEFGLLQRTEELLKQRHENIQQ-QLQTMEEKKGISGYSYTQEELERVSALK 472
            H    E KA     Q  E L ++    +   ++ T ++ +      Y+Q  +++   L+
Sbjct: 104 CHSPEDEQKASH---QHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQ---LE 157

Query: 473 SEVDEMKGRTLDDMS---EMVKKLYSLVSEKKSA---LASVIKELRQLRQKYQELT---Q 523
            E  ++  R  D      E+ + L ++ ++KK A   +  + KE   L  +    T   +
Sbjct: 158 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE 217

Query: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREEC---------LQEESRYHYTNCMIKNL 574
           E  EK ++       +ES +S+++  V+ L+ +           Q ++   +    ++++
Sbjct: 218 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 277

Query: 575 EVQLRRATDEMKAYISSDQQEKRKAIREQ-----YTKNTAEQENLGKKLREKQKVIRESH 629
             +L+   +E + +   +QQ++ K  R++     + +   EQE   +K+RE+++ IRE  
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQE 334

Query: 630 GPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659
               +Q +M  + E+ M  +++   +++ +
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 364



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 42/225 (18%), Positives = 102/225 (45%), Gaps = 16/225 (7%)

Query: 460 YTQEELERVSALKSEV--DEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQK 517
           Y +E  +   AL  E+  + +    L + +  +++   LV  +KS +   +KEL++  ++
Sbjct: 194 YIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER 253

Query: 518 ------YQELTQECDEKKSQYDSCAAGLESN--RSKLEQEVRRLREECL-QEESRYHYTN 568
                  Q+L  E D    +  S +A L++    ++L   + + +EE + ++E +     
Sbjct: 254 AKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE 313

Query: 569 CMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRES 628
             I+  E ++R   ++++     +Q+EK +   E   +   +     + + EK++ +R  
Sbjct: 314 EKIQEQEEKIREQEEKIR-----EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368

Query: 629 HGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDR 673
                ++ +  R  E++M  K++   + + +    + I+E  E R
Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 413


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
            [Homo sapiens]
          Length = 1388

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 102/498 (20%), Positives = 221/498 (44%), Gaps = 50/498 (10%)

Query: 175  ISAMEEEKDQLIKRVEHLKKRVETAQ-NHQWMLKIARQLRVEKEREEYLAQQKQEQKNQL 233
            ++ +E EK QL +R   L+K     + +  + LK+ +Q   ++E E    + +   KN++
Sbjct: 662  LAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKI 721

Query: 234  FHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELH 293
            + +++             +A ++A  E   K LEE        + +K    L   +K   
Sbjct: 722  YESIE-------------EAKSEAMKEMEKKLLEERT------LKQKVENLLLEAEKRCS 762

Query: 294  FLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISR 353
             L   + +     ++LL+ +  +NE    +   IE++  +    +  L +  QQ + +  
Sbjct: 763  LLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKM 822

Query: 354  KKEAKAEELQEAKEKLASLEREASVKRNQTREFDG--TEVLKGDEFKRYVNKLRSKSTVF 411
             ++   +E     E   +LE++ +  R + ++ DG   E+    E ++Y + L  K+ V 
Sbjct: 823  SEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTL-YKTQVR 881

Query: 412  KKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEK-------KGISGYSYTQEE 464
            + K +   + K    L Q+ +EL  +R +++  QL+    K       + I+   Y+  E
Sbjct: 882  ELKEECEEKTKLGKELQQKKQELQDER-DSLAAQLEITLTKADSEQLARSIAEEQYSDLE 940

Query: 465  LERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKK---SALASVIKELRQLRQKYQEL 521
             E++   + E+ EM  R   +++E    + SL    +   S +A++  E  +L  K +++
Sbjct: 941  KEKIMK-ELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDV 999

Query: 522  TQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRA 581
             ++    K +  S AA       K + E + L E  L+       T  + K  E+  R+ 
Sbjct: 1000 QEQLSRLKDEEISAAA------IKAQFEKQLLTERTLK-------TQAVNKLAEIMNRK- 1045

Query: 582  TDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRD 641
             + +K    +D + K K  R+ + +  +E+E L +++ + QK + E      +++++  +
Sbjct: 1046 -EPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIE 1104

Query: 642  LEQLMECKKQCFLKQQSQ 659
            L+  ++ K     + +SQ
Sbjct: 1105 LQMTLDSKDSDIEQLRSQ 1122



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 90/429 (20%), Positives = 186/429 (43%), Gaps = 61/429 (14%)

Query: 137  VADTNKQYEELMEA--------------FKTLHKEYEQLKISGFSTAEI--------RKD 174
            +AD NK YE + EA               +TL ++ E L +       +        ++ 
Sbjct: 715  LADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQK 774

Query: 175  ISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLF 234
            I+ + ++KD L + V +L  ++E  Q  Q        L+++ ++   L   +++ K +  
Sbjct: 775  INELLKQKDVLNEDVRNLTLKIE--QETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENN 832

Query: 235  HAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVT--EKFPKELENKKKEL 292
            H ++    ++ Q   +R+   DA  +  MK L+++++   Y  T  +   +EL+ + +E 
Sbjct: 833  HLMEMKMNLEKQNAELRKERQDA--DGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEK 890

Query: 293  HFLQKVVSEPAMGHSDLLELESKINEINTEINQL---IEKKMMRNEPIEGKLSLYRQQAS 349
              L K             EL+ K  E+  E + L   +E  + + +  +   S+  +Q S
Sbjct: 891  TKLGK-------------ELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYS 937

Query: 350  IISRKKEAKAEELQE--AKEKLASLEREASV----KRNQTREFDGTEVL-KGDEFKRYVN 402
             + ++K  K  E++E  A+ K    E++A++    + N+T   D   +  + +E    + 
Sbjct: 938  DLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLK 997

Query: 403  KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEE--KKGISGYSY 460
             ++ + +  K +    A +KA+F     TE  LK +  N   ++   +E  K+G      
Sbjct: 998  DVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVR 1057

Query: 461  TQEELERV--SALKSEVDEMK------GRTLDDMSEMVKKLYSLVSEKKSALASVIKELR 512
             +E+  R     LKSE +++        + L++M   + +   +  E +  L S   ++ 
Sbjct: 1058 RKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIE 1117

Query: 513  QLRQKYQEL 521
            QLR + Q L
Sbjct: 1118 QLRSQLQAL 1126



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 44/226 (19%), Positives = 99/226 (43%), Gaps = 36/226 (15%)

Query: 457 GYSYTQEELERVSALKS-EVDEMKGRTLDDMSEMVKKLYSL---VSEKKSALASVIKELR 512
           G++Y +E L    +    E D ++ R  ++  E+ KKLY+L   +S +  A   + ++ +
Sbjct: 412 GFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCK 471

Query: 513 QLRQKYQELTQECDE------------------------KKSQYDSCAAGLESNRSKLEQ 548
            +  + ++  +E +E                        K ++Y   A      +  LE 
Sbjct: 472 SVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLEN 531

Query: 549 EVRRLREECLQEESRYHYTNCMIKNLEV-QLRRATDEMKAYI--SSDQQEKRKAIREQYT 605
           +V  L+++   E+ +    N  I   +V QL+R  DE  A +   SD   + +  + + +
Sbjct: 532 DVNSLKDQL--EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESS 589

Query: 606 KNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQ 651
           K   + E+  + L++K  ++  +    +K  K + +L+  +E +++
Sbjct: 590 KQIQQLESNNRDLQDKNCLLETA---KLKLEKEFINLQSALESERR 632



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 81/430 (18%), Positives = 174/430 (40%), Gaps = 75/430 (17%)

Query: 29   LEPMQLLQVLSDVLAEIDPK-QLVDIREEMPEQTAKRMLSLLGILKYKPSGNAT---DMS 84
            LE   L Q + ++L E + +  L+D   +  +Q    +L    +L  +   N T   +  
Sbjct: 741  LEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLN-EDVRNLTLKIEQE 799

Query: 85   TFRQGLVIGSKPVIYPVLHWLLQRTNELKKRA-YLARFLIKLEVPSEFLQDETVADTNKQ 143
            T ++ L      +    ++ L     +LK+   +L    + LE  +  L+ E   D + Q
Sbjct: 800  TQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKER-QDADGQ 858

Query: 144  YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQ 203
             +EL +          QL+   + +   +  +  ++EE ++  K  + L+++ +  Q+ +
Sbjct: 859  MKELQD----------QLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDER 908

Query: 204  WMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLM 263
              L    ++ + K   E LA+   E++                        +D + E +M
Sbjct: 909  DSLAAQLEITLTKADSEQLARSIAEEQ-----------------------YSDLEKEKIM 945

Query: 264  KRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEI 323
            K LE      +  +  +  +EL  K   +  L++         SD+  L ++  E+N ++
Sbjct: 946  KELE------IKEMMARHKQELTEKDATIASLEETNRTLT---SDVANLANEKEELNNKL 996

Query: 324  NQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQT 383
               +++++ R         L  ++ S  + K + + + L E   K  ++ + A +   + 
Sbjct: 997  KD-VQEQLSR---------LKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRK- 1045

Query: 384  REFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQ 443
                   V +G++       +R K    +K H    ELK+E   L  T++++K + E  +
Sbjct: 1046 -----EPVKRGND-----TDVRRKEKENRKLHM---ELKSEREKL--TQQMIKYQKELNE 1090

Query: 444  QQLQTMEEKK 453
             Q Q  EE +
Sbjct: 1091 MQAQIAEESQ 1100


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 92/466 (19%), Positives = 206/466 (44%), Gaps = 64/466 (13%)

Query: 136  TVADTNKQYEELMEAFKTLHKEYE----QLKISGFSTAEIRKDISAMEEE----KDQLIK 187
            ++++  K  E+++E  + + +E E    + +++   +   R+ +  +E E    +D L  
Sbjct: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244

Query: 188  RVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQL 247
              E ++   +T   H+ ++K    + V  E  + L ++K+  +  L     ++++++  +
Sbjct: 1245 EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI 1304

Query: 248  KSMRQAAADAKPESLM-----KRLEEEIKF----NLYMV-------TEKFPKELENKKKE 291
              +++A A+   +S M     K LEE++K     N ++V       TE++ K L  K+  
Sbjct: 1305 LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVH 1364

Query: 292  LHFLQKVV-------SEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLY 344
               +Q++        +E A  ++ L   ++ I  +  ++N++  +K    + ++ K+   
Sbjct: 1365 TKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDI 1424

Query: 345  RQ------QASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFK 398
            ++      Q   I R+ + + EEL+  ++K+     E S + +   +     V +  E K
Sbjct: 1425 QEKVKTITQVKKIGRRYKTQYEELKAQQDKVM----ETSAQSSGDHQEQHVSVQEMQELK 1480

Query: 399  RYVNKLRSKSTVFKKK----HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKG 454
              +N+  +KS   + +     + ++E + E   LQ     L+     ++Q LQ       
Sbjct: 1481 ETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRT---- 1536

Query: 455  ISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQL 514
                  TQEE      L+ ++ E + +T   +     K+  L   K      + KE  +L
Sbjct: 1537 ------TQEE-----QLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQ----LTKENEEL 1581

Query: 515  RQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQE 560
            +Q+   L Q+ DE   +  +  +  E   S+LE+E+R  +E  L++
Sbjct: 1582 KQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQ 1627



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 97/428 (22%), Positives = 188/428 (43%), Gaps = 49/428 (11%)

Query: 197  ETAQNHQWMLKIARQLRVEKEREEY---LAQQKQEQKNQLFHAVQR-LQRVQNQLKSMRQ 252
            E  ++ + +L+I R +R EKE  E    +AQ +  +  Q    ++R LQ +Q+ L + R+
Sbjct: 1188 EEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAERE 1247

Query: 253  -----AAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHS 307
                 A   A+ E LMK+ E     N+ M T K  +E   K++    LQ++ ++      
Sbjct: 1248 KVQVTAKTMAQHEELMKKTET---MNVVMETNKMLRE--EKERLEQDLQQMQAKVRKLEL 1302

Query: 308  DLLELESKINEINTEINQL-IEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAK 366
            D+L L+    E++ +   L  EKK++  +    K     +   ++S++K+   EE +   
Sbjct: 1303 DILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKA----RNQHLVSQQKDPDTEEYR--- 1355

Query: 367  EKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFG 426
             KL S E+E   KR Q            +E  R   ++   +        +I  LK +  
Sbjct: 1356 -KLLS-EKEVHTKRIQQLT---------EEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404

Query: 427  LLQRTEELLKQRHE----NIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRT 482
             ++  +E +++  +    +IQ++++T+ + K I     TQ   E + A + +V E   ++
Sbjct: 1405 KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ--YEELKAQQDKVMETSAQS 1462

Query: 483  LDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESN 542
              D  E    +  +  E K  L     + + L  + + L +   EK+++    A  L+  
Sbjct: 1463 SGDHQEQHVSVQEM-QELKETLNQAETKSKSLESQVENLQKTLSEKETE----ARNLQEQ 1517

Query: 543  RSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIRE 602
              +L+ E+ RLR++     ++       I   E + R+A    K+ I+         +++
Sbjct: 1518 TVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIA-----HLAGVKD 1572

Query: 603  QYTKNTAE 610
            Q TK   E
Sbjct: 1573 QLTKENEE 1580



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 97/498 (19%), Positives = 208/498 (41%), Gaps = 33/498 (6%)

Query: 142  KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201
            KQ +E+ E +K    E E  KI      ++++ ++ +  +  ++  +++   KR E  Q+
Sbjct: 673  KQLQEIFENYKKEKAENE--KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQD 730

Query: 202  HQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPES 261
            +  +    R++    ER + L    Q+Q+  +    Q L+    +L      A + K E 
Sbjct: 731  N--VEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788

Query: 262  LMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLE-LESKINEIN 320
             M +L E     L    E    E   +   L  LQ +        ++  + L S+I ++ 
Sbjct: 789  EMLKLSE---VRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLE 845

Query: 321  TEINQLIEKKMMRNEPIEGKLSLYRQ-QASIISRKKEAKAEE---------LQEAKEKLA 370
             EI+ L  KK + NE +E + +L R     ++  K++   E          L+ A++++A
Sbjct: 846  HEISHL--KKKLENE-VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902

Query: 371  SLEREASVKRNQTREFDGTEVLKG-----DEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425
            +L++  S    Q          KG     ++    V++LR      ++ + +   LK   
Sbjct: 903  TLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE---EQVNDLKERLKTST 959

Query: 426  GLLQRTEELLKQRHENIQQQLQTMEE-KKGISGYSYTQEELERVSALK-SEVDEMKGRTL 483
              +++ + ++    E++ ++ Q  EE +K I        E +     K  EV++ K    
Sbjct: 960  SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ 1019

Query: 484  DDMSEMVKKLYSLVSEKKSALASVIKELRQ-LRQKYQELTQECDEKKSQYDSCAAGLES- 541
            DD    ++ +   +SE K  L+SV  E+++ L++    L+ E   ++   +     +E+ 
Sbjct: 1020 DDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQ 1079

Query: 542  NRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIR 601
            N+ + E  +     E LQ           ++    +  +  +       +  +E+ + ++
Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139

Query: 602  EQYTKNTAEQENLGKKLR 619
            ++ +K     E+L K+ R
Sbjct: 1140 DEVSKCVCRCEDLEKQNR 1157



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 100/465 (21%), Positives = 183/465 (39%), Gaps = 73/465 (15%)

Query: 124 KLEVPSEFLQDETV---ADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
           +LE   E L  +      +   + +EL+   +    E  +LK +       ++++S +EE
Sbjct: 182 RLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCN---LENKKEEVSRLEE 238

Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
           + + L    EHL+K VE              L   KE +E  A  +++  N+L       
Sbjct: 239 QMNGLKTSNEHLQKHVEDL------------LTKLKEAKEQQASMEEKFHNEL------- 279

Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
                +L ++ ++AAD          + E K N          EL    +ELH L K   
Sbjct: 280 -NAHIKLSNLYKSAAD----------DSEAKSN----------ELTRAVEELHKLLKEAG 318

Query: 301 EPAMGHSD-LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKA 359
           E      D LLE+E   +++  E+ + I +     E     LS  +++ +I+S ++ A  
Sbjct: 319 EANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAM 378

Query: 360 EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIA 419
                A  K+     + +   N   E     +L+  E KR    L       + K  I+ 
Sbjct: 379 SPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILK 438

Query: 420 ELKAEFGLLQRTEELLKQRHENIQQQLQTMEE-----KKGISGYSYTQEELE-------- 466
             + E+   Q+    L  + E   +++Q ++E      K  S        +E        
Sbjct: 439 RQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQ 498

Query: 467 RVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQEL----- 521
           ++  L  E++E +G  +    E+     S  SE  S      + + +L+Q+ Q L     
Sbjct: 499 QIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALR 558

Query: 522 ----TQECDEKK---SQYDSCAAGLESNRSKLEQEVRRLREECLQ 559
               T+E +E++   S+       LES  ++LEQ +R+ R+  +Q
Sbjct: 559 ELGETREREEQETTSSKITELQLKLESALTELEQ-LRKSRQHQMQ 602



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 75/349 (21%), Positives = 145/349 (41%), Gaps = 60/349 (17%)

Query: 343 LYRQQASIISRKKEAKAEE-LQEAKEKLASLE-REASVKRNQTREFDGTEVLKGDEFKRY 400
           L R + + + +  + K E+ L + + ++  L+ R    K    +++   E       +R 
Sbjct: 9   LERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERL 68

Query: 401 VNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSY 460
           VN+ R   ++  +  ++  +LKA   L ++ +EL   +  NI  Q Q          ++ 
Sbjct: 69  VNETRECQSLRLELEKLNNQLKA---LTEKNKELEIAQDRNIAIQSQ----------FTR 115

Query: 461 TQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQ---- 516
           T+EELE         +E   + L+ ++E VK+L   + E  +    +  +L +L+     
Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVS 175

Query: 517 -KYQE--LTQECD-----------EKKSQYDSCAA----------GLESNRSKLEQEVRR 552
            KY+E  L QE +           E K++ D   A           L+ N    ++EV R
Sbjct: 176 VKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSR 235

Query: 553 LREE-----CLQEESRYHYTNCMIKNLEVQLRRAT------DEMKAYIS-----SDQQEK 596
           L E+        E  + H  + + K  E + ++A+      +E+ A+I          + 
Sbjct: 236 LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADD 295

Query: 597 RKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645
            +A   + T+   E   L K+  E  K I++ H   ++Q+K   + E L
Sbjct: 296 SEAKSNELTRAVEELHKLLKEAGEANKAIQD-HLLEVEQSKDQMEKEML 343


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 121/572 (21%), Positives = 264/572 (46%), Gaps = 66/572 (11%)

Query: 126  EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185
            E  ++  Q+E +    K  E+L +  + + +E E+L   G    ++ +    + +++++ 
Sbjct: 1765 EEETKLAQEEELLIQEK--EKLAQHKEKMPEEEERL---GRKREQLIEKKMKLAQKRERW 1819

Query: 186  IKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQE---QKNQLFHAVQRLQR 242
            I  +E L K        + + +  + L  EKE+   LAQ+K+     K +L H+ ++L +
Sbjct: 1820 INSMEELTKNKMILYQKKNLAQEKKNLAQEKEK---LAQRKENLLYNKERLTHSKKQLVQ 1876

Query: 243  VQNQLKSMRQAAADA------KPESLMKRLEE--EIKFNLYMVTEKFPKELENKKKELHF 294
            V+N+L    +  A        + E+++K+ E+  E +  L  V +   K+ E   +E   
Sbjct: 1877 VKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQE--- 1933

Query: 295  LQKVVSEPAM--GHSDL---LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS 349
              K+  E AM  G   L   L++  +   +N E+ +L E+KM     +EGK +L + +  
Sbjct: 1934 KMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKM---RLVEGKETLSKGETP 1990

Query: 350  IISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGD-EFKR----YV--- 401
              SR+++    E QE  E+  SLE +  +  ++    + +E+ KG  EF R    +V   
Sbjct: 1991 ETSRQRKMTQVE-QELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQ 2049

Query: 402  NKLRSKSTVFKKKHQIIAELKAEFG-LLQRTEELLKQRHENIQQQLQTMEEKKGISGYSY 460
             KL   S    KK + +++  A+   +L+  ++L +   +  Q++++  + K+ +    +
Sbjct: 2050 RKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRAL----F 2105

Query: 461  TQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQE 520
             +E   R+S  +S++D  +    +  SE+ K    L  +++     +  ++R++  K ++
Sbjct: 2106 VKE--RRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQR----KLANKMRRMINKEEK 2159

Query: 521  LTQECDEKKSQYDSCAAGLESNRSKLEQEV-------RRLREECLQEESRYHYTNCMIKN 573
            +T+E  +   ++       E      E+EV        R R+E  + +      +  +  
Sbjct: 2160 MTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDE 2219

Query: 574  LE------VQLRRATDEMKAY--ISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVI 625
            +E       ++    DE++    +SS+++E+R+   E+  +   E+E   K+  E ++  
Sbjct: 2220 VESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQ 2279

Query: 626  RESHGPNMKQAKMWRDLEQLMECKKQCFLKQQ 657
             E      K+ K  +  E++ E K++ F +++
Sbjct: 2280 VEKEEEEKKKKKKEKKKEEVQE-KEEVFEEKE 2310



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 118/568 (20%), Positives = 237/568 (41%), Gaps = 72/568 (12%)

Query: 124  KLEVPSEFLQDETVADTNKQYEELMEAFKT-LHKEYEQLKISGFSTAEIRKDISAMEEEK 182
            KL    E LQ+    D   ++EE  + ++  L  + ++ +        + +++S   EEK
Sbjct: 1502 KLSPEEEMLQE----DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEK 1557

Query: 183  DQ-LIKRVEHLKKRVETAQNHQWMLKIARQLRVEKER---EEYLAQQKQ---EQKNQLFH 235
            +Q + +   H++      + H+W     ++ R EK+R   E  LAQ+++   +++ QL  
Sbjct: 1558 EQQVTEEQRHIQ------EEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQ 1611

Query: 236  AVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFL 295
              ++L   Q  +K  +     A+ E    + EE     L    EK  +E E   ++   L
Sbjct: 1612 EERKL--AQAYVKITQDDREMAQAEGKFAQKEE----TLAQRGEKLSQEAEKLAQKRKKL 1665

Query: 296  QKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355
             K   + A     L +   K+ E+   + Q +E+   R + ++               ++
Sbjct: 1666 AKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDW--------------QE 1711

Query: 356  EAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKH 415
            +  A+EL+E +  +     E S K  +  + +G  V   +E K    KL  +      + 
Sbjct: 1712 KELAQELEELEWDM----EELSWKEEELNQEEGKLV---EEKK----KLAEEEEALAWQR 1760

Query: 416  QIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEV 475
            + ++E + +   L + EELL Q  E + Q  + M E++   G      + E++   K ++
Sbjct: 1761 EKLSEEETK---LAQEEELLIQEKEKLAQHKEKMPEEEERLG-----RKREQLIEKKMKL 1812

Query: 476  DEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSC 535
             + + R ++ M E+ K    ++  +K  LA   K L Q ++K  +  +     K +    
Sbjct: 1813 AQKRERWINSMEELTKN--KMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHS 1870

Query: 536  AAGLESNRSKL---EQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSD 592
               L   ++KL    + + ++ E+  QE+         +   E +L +  D +       
Sbjct: 1871 KKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKL 1930

Query: 593  QQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQC 652
             QEK K   E+            K+LR +  + +E    N++  ++  +  +L+E K+  
Sbjct: 1931 AQEKMKLALEKAMVQGK------KRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETL 1984

Query: 653  FLKQQSQTS----IGQVIQEGGEDRLIL 676
               +  +TS    + QV QE  E +L L
Sbjct: 1985 SKGETPETSRQRKMTQVEQELFERKLSL 2012



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 75/353 (21%), Positives = 161/353 (45%), Gaps = 37/353 (10%)

Query: 172  RKDISAMEEEKDQLIKRVEHLKK-RVETAQNHQWMLKIARQLRVEKEREEYLAQQK---- 226
            R+ +S    + ++++K ++ L +   +  Q    M K+ R L V KER   + Q K    
Sbjct: 2063 RESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFV-KERRLSIEQSKLDIK 2121

Query: 227  ----QEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFP 282
                 E++++L    ++L R Q +L +  +   + + +   +  +   K +  ++ ++  
Sbjct: 2122 EWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEE 2181

Query: 283  KELENKKKELHFLQK---VVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEG 339
              +E +++ + FL++      E   G     +  S+++E+ +E +         +E +E 
Sbjct: 2182 GGIE-EEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHF--------SEEMES 2232

Query: 340  KLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKR 399
             L    +Q S+ S ++E + EE +  +E++    RE   +R +  E +  +V K +E K+
Sbjct: 2233 LLDELEKQESLSSEEEEEREEEEEREEEEV----REEEEERKEEEEGEEKQVEKEEEEKK 2288

Query: 400  YVNK------LRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKK 453
               K      ++ K  VF++K +I++E + E    +  EE      E + ++ + ++++K
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEK 2348

Query: 454  GISGYSYTQEEL---ERVSALKSEVDEMKGRT--LDDMSEMVKKLYSLVSEKK 501
                    ++ L   ERV ++   V   KGR   L  +   +KKL S   E K
Sbjct: 2349 QFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMK 2401



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 68/352 (19%), Positives = 149/352 (42%), Gaps = 40/352 (11%)

Query: 322  EINQLIEKKMMRNEPIEGKLSLYRQQ-ASIISRKKEAKAEELQEAKEKLASLEREASVKR 380
            EI++  EKK  +  P +G+ ++ +++    I R+   +  ++ E  E++A+LE +   + 
Sbjct: 1386 EISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQE 1445

Query: 381  NQTREFDGTEVLKG-----DEFKRYVNKLRSKSTVFK------------KKHQIIAELKA 423
             +    + T   +      DE+K+   + R     +K            K HQ   +L  
Sbjct: 1446 GKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSP 1505

Query: 424  EFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTL 483
            E  +LQ  ++L   + E  +Q  + M   K        +EE+     +  E +E + +  
Sbjct: 1506 EEEMLQEDKKL---KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVT 1562

Query: 484  DDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNR 543
            ++   + ++       +K A A      ++  Q+ ++L QE +EK +Q +   A  E   
Sbjct: 1563 EEQRHIQEEHKWARIHRKRARAE-----KKRAQEERKLAQE-EEKLAQEERQLAQEERKL 1616

Query: 544  SKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQ 603
            ++   ++ +   E  Q E ++      +     +L +  +++         +KRK + ++
Sbjct: 1617 AQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLA--------QKRKKLAKK 1668

Query: 604  YTKNTAEQENLGK---KLREKQKVIRE--SHGPNMKQAKMWRDLEQLMECKK 650
            + K   E+E L K   KL E + ++ +     P  +Q   W++ E   E ++
Sbjct: 1669 WEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEE 1720



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 84/474 (17%), Positives = 194/474 (40%), Gaps = 68/474 (14%)

Query: 135  ETVADTNKQYEELMEAFKTLHKEYEQLK---------ISGFSTAEIRKDISAMEEEKDQL 185
            E +A+T K+  ++ ++     ++  Q K         + G        DI+  E+  +  
Sbjct: 1907 EKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLE 1966

Query: 186  IKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN 245
            +KR+   K R+   +       +++    E  R+  + Q +QE   +     +++   ++
Sbjct: 1967 MKRLAEEKMRLVEGKE-----TLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHED 2021

Query: 246  QLKSMRQAA-ADAKPESLM-KRLEEEIKFNLYMVTEKFPKELENKKKE---LHFLQKVVS 300
            ++ +M ++  A  K E    +R+  + +  L   + K  K+ E+  KE   L+ + K + 
Sbjct: 2022 RILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQ 2081

Query: 301  EPAMGHSDLLELESKINEINT-----EINQLIEKKMM----------RNEPIEGKLSLYR 345
            +       L + E K+ ++       E    IE+  +          R+E  + +  L R
Sbjct: 2082 KLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLAR 2141

Query: 346  QQASIISRKKEA--KAEELQEAKEKLASLEREASVKRNQTREFDGTEVL----------- 392
            +Q  + ++ +    K E++ E + KLA    E  +   +    +  EV+           
Sbjct: 2142 KQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRK 2201

Query: 393  ---KGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTM 449
               +GD+ K    K  S+    + +     E+++    L++ E L  +  E  +++ +  
Sbjct: 2202 EAKRGDKPKE---KFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEERE 2258

Query: 450  EEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIK 509
            EE+         +EE      ++ E +E K +  +   E V++   +  EK+  ++    
Sbjct: 2259 EEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMS---- 2314

Query: 510  ELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESR 563
                     +E T+   +++ + +SC+   E +R K  + +++ ++  LQE+ R
Sbjct: 2315 ---------EEETESLSDEEEEEESCSLEEEVDREK--EILKKEKQFKLQEQRR 2357



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 34/144 (23%), Positives = 66/144 (45%), Gaps = 11/144 (7%)

Query: 170  EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQ 229
            E+ K  S   EE+++  +  E  ++ V   +  +   +   + +VEKE EE   ++K+++
Sbjct: 2236 ELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKK 2295

Query: 230  KNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKK 289
            K ++       Q  +   +   +  ++ + ESL    EEE   +L    E+  +E E  K
Sbjct: 2296 KEEV-------QEKEEVFEEKEEIMSEEETESLSDEEEEEESCSL---EEEVDREKEILK 2345

Query: 290  KELHF-LQKVVSEPAMGHSDLLEL 312
            KE  F LQ+   +   G   +L +
Sbjct: 2346 KEKQFKLQEQRRKSLRGRERVLSI 2369


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 132/594 (22%), Positives = 251/594 (42%), Gaps = 115/594 (19%)

Query: 111  ELKKRAYLARFLIKLEVPSEFLQDET------VADTN----KQYEELMEAFKTLHKEYEQ 160
            E K+R  L +   KLE  S  L D+       +A+      K+ EEL  A   + +E  Q
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ 1098

Query: 161  LKISGFSTAEIRKDISAMEEE--------------KDQLIKRVEHLKKRVETAQNHQWML 206
              ++     E+   IS ++E+              K  L + +E LK  +E   +     
Sbjct: 1099 KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST--- 1155

Query: 207  KIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRL 266
               ++LR ++E+E  + ++  E++ +   A         Q++ MRQ  + A  E L ++L
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEA---------QIQEMRQKHSQAV-EELAEQL 1205

Query: 267  EE--EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSD---------LLELESK 315
            E+   +K NL    EK  + LEN++ EL    KV+ +   G S+         L EL+ K
Sbjct: 1206 EQTKRVKANL----EKAKQTLENERGELANEVKVLLQ-GKGDSEHKRKKVEAQLQELQVK 1260

Query: 316  INE---INTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASL 372
             NE   + TE+   + K  +  + + G LS    ++S +++   A   +LQ+ +E L   
Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320

Query: 373  EREA---SVKRNQTREFDGT--EVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGL 427
             R+    S K  Q  +   +  E L+ +E  ++ N  +  +T+  +   +  +++   G 
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH-NLEKQIATLHAQVADMKKKMEDSVGC 1379

Query: 428  LQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEM------KGR 481
            L+  EE+ ++  ++++   Q  EEK  ++ Y   ++   R   L+ E+D++      + +
Sbjct: 1380 LETAEEVKRKLQKDLEGLSQRHEEK--VAAYDKLEKTKTR---LQQELDDLLVDLDHQRQ 1434

Query: 482  TLDDMSEMVKKLYSLVSEKKSALASVIKE------------------------------- 510
            +  ++ +  KK   L++E+K+  A   +E                               
Sbjct: 1435 SACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494

Query: 511  LRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCM 570
            L +L ++++   ++    K         LE ++  LEQ+V  ++ +  + E     T   
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554

Query: 571  IKNLEVQLRRATDEMKAYISSDQQ-------EKRKAIREQYTKNTAEQENLGKK 617
               LEV L+     MKA    D Q       EK+K +  Q  +  AE E+  K+
Sbjct: 1555 KLRLEVNLQ----AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ 1604



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 101/561 (18%), Positives = 232/561 (41%), Gaps = 49/561 (8%)

Query: 138  ADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVE 197
            A+  K  + + E  + L +E    +            +  +EEE  Q+I   ++ K   E
Sbjct: 936  AEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE--QIILEDQNCKLAKE 993

Query: 198  TAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADA 257
                   + +    L  E+E+ + LA+ K + +  +    +RL+R + Q + + +     
Sbjct: 994  KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053

Query: 258  KPESL-MKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKI 316
            + +S  +     E++  +  +  +  K+ E  +  L  +++  ++  M    + ELES+I
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113

Query: 317  NEINTEI-------NQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKL 369
            +E+  ++       N+  ++K    E +E   +         + ++E +++  QE     
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173

Query: 370  ASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQII----AELKAEF 425
             +LE EA     Q +E         +E    + + +      +K  Q +     EL  E 
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233

Query: 426  GLLQRTEELLKQRHENIQQQLQTMEEK---------KGISGYSYTQEELERVSALKSEVD 476
             +L + +   + + + ++ QLQ ++ K         +     +  Q EL+ V+ L S+ D
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293

Query: 477  EMKGRTLDDMSEM------VKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS 530
                +   D S +       ++L    + +K +L++ +K++   +  ++E  +E +E K 
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353

Query: 531  QYDSCAAGLESN----RSKLE---------QEVRRLREECLQEESRYHYTNC----MIKN 573
              +   A L +     + K+E         +EV+R  ++ L+  S+ H         ++ 
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413

Query: 574  LEVQLRRATDEMKAYISSDQQEKRKAIREQ--YTKNTAEQENLGKK-LREKQKVIRESHG 630
             + +L++  D++   +   +Q      ++Q  + +  AE++ +  K   E+ +   E+  
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473

Query: 631  PNMKQAKMWRDLEQLMECKKQ 651
               K   + R LE+ ME K +
Sbjct: 1474 KETKALSLARALEEAMEQKAE 1494



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 116/576 (20%), Positives = 240/576 (41%), Gaps = 55/576 (9%)

Query: 124  KLEVPSEFLQDE-----TVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAM 178
            +L+   E LQ+E     +++   KQ E+   +F+   +E E+ K +      + K I+ +
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHN------LEKQIATL 1362

Query: 179  EEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQ 238
              +   + K++E     +ETA+  +  L+   +   ++  E+  A  K E+        Q
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ--Q 1420

Query: 239  RLQRVQNQLKSMRQAAA--DAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQ 296
             L  +   L   RQ+A   + K +   + L EE   +     E+   E E ++KE   L 
Sbjct: 1421 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480

Query: 297  KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKE 356
                  A    + +E ++++  +N +    +E  M   + + GK          + + K 
Sbjct: 1481 L-----ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV-GK------SVHELEKSKR 1528

Query: 357  AKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQ 416
            A  ++++E K +L  LE E     +     +        +F+R +   R + +  KKK  
Sbjct: 1529 ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG-RDEQSEEKKKQL 1587

Query: 417  I--IAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474
            +  + E++AE    ++   +     + ++  L+ +E     S      E ++++  L+++
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID-SANKNRDEAIKQLRKLQAQ 1646

Query: 475  VDEMKGRTLDDM-----------SEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQ 523
            + +   R LDD             E  KKL S+ +E       +    R  RQ  QE  +
Sbjct: 1647 MKDCM-RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE 1705

Query: 524  ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATD 583
              DE  +     A  LE  R +LE  + +L EE  +E+      N  +K   +Q+ +   
Sbjct: 1706 LADEIANSSGKGALALEEKR-RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT 1764

Query: 584  EMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMK--QAKMWRD 641
            ++   +     +K +  R+Q  +   E   L  KL+E +  ++  +  ++   +AK+ + 
Sbjct: 1765 DLN--LERSHAQKNENARQQLERQNKE---LKVKLQEMEGTVKSKYKASITALEAKIAQL 1819

Query: 642  LEQL----MECKKQCFLKQQSQTSIGQVIQEGGEDR 673
             EQL     E +  C   ++++  +  V+ +  ++R
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER 1855



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 83/409 (20%), Positives = 182/409 (44%), Gaps = 56/409 (13%)

Query: 134  DETVADTNKQYEELMEAFKTLHKEYEQLKIS-GFSTAEIRKDISAM----EEEKDQLIKR 188
            ++ V +   Q EEL +  +       +L+++     A+  +D+       EE+K QL+++
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1590

Query: 189  VEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLK 248
            V  ++  +E  +  + M   AR+ ++E + ++  A      KN+   A+++L+++Q Q+K
Sbjct: 1591 VREMEAELEDERKQRSMAVAARK-KLEMDLKDLEAHIDSANKNR-DEAIKQLRKLQAQMK 1648

Query: 249  -----------SMRQAAADAKP--------ESLMKRLEEEIKFNLYMVTEKFPKELENKK 289
                       S  +  A AK         E+ M +L+EE+        E+  ++ + ++
Sbjct: 1649 DCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL-----AAAERAKRQAQQER 1703

Query: 290  KEL-HFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQA 348
             EL   +     + A+   +   LE++I ++  E+ +      + N+ ++ K +L   Q 
Sbjct: 1704 DELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK-KANLQIDQI 1762

Query: 349  SIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS 408
            +     + + A++ + A+++L    +E  VK    +E +GT   K   +K  +  L +K 
Sbjct: 1763 NTDLNLERSHAQKNENARQQLERQNKELKVK---LQEMEGTVKSK---YKASITALEAKI 1816

Query: 409  TVFKKK-HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYT------ 461
               +++      E +A    ++RTE+ LK     +  + +  E+ K  +  + T      
Sbjct: 1817 AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLK 1876

Query: 462  ------QEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSAL 504
                  +EE +R +A + ++     R L+D +E    +   VS  K+ L
Sbjct: 1877 RQLEEAEEEAQRANASRRKLQ----RELEDATETADAMNREVSSLKNKL 1921



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 87/454 (19%), Positives = 195/454 (42%), Gaps = 68/454 (14%)

Query: 221  YLAQQKQEQKNQLFHAVQRLQRVQNQLKSMR-----QAAADAKPESLMKRLEEEIKFNLY 275
            YLA++   ++ Q   A++ LQR       +R     +     KP   + R EEE+     
Sbjct: 793  YLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEE 852

Query: 276  MVTEKFPKEL--ENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMR 333
             + +   K+L  EN+  E+  LQ  +    +   + L+ E+++                 
Sbjct: 853  ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL--------------CAE 898

Query: 334  NEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLK 393
             E +  +L+  +Q+   I    EA+ EE +E  + L     +A  K+ Q    +  E L+
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEEEERCQHL-----QAEKKKMQQNIQELEEQLE 953

Query: 394  GDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKK 453
             +E  R   +L   +T  K K             L+  + +L+ ++  + ++ + +E++ 
Sbjct: 954  EEESARQKLQLEKVTTEAKLKK------------LEEEQIILEDQNCKLAKEKKLLEDRI 1001

Query: 454  GISGYSYTQEE--LERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKEL 511
                 + T+EE   + ++ LK++ + M    + D+ E +++      E+K       +EL
Sbjct: 1002 AEFTTNLTEEEEKSKSLAKLKNKHEAM----ITDLEERLRR------EEKQR-----QEL 1046

Query: 512  RQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMI 571
             + R+K +  + +  ++ ++  +  A L+   +K E+E++       +E ++ +     I
Sbjct: 1047 EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI 1106

Query: 572  KNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGP 631
            + LE Q+            S+ QE  ++ R    K   ++ +LG++L   +  + ++   
Sbjct: 1107 RELESQI------------SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDS 1154

Query: 632  NMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQV 665
               Q ++    EQ +   K+  L+++++T   Q+
Sbjct: 1155 TAAQQELRSKREQEVNILKKT-LEEEAKTHEAQI 1187


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 140/622 (22%), Positives = 268/622 (43%), Gaps = 82/622 (13%)

Query: 94  SKPVIYPVLHWLLQRTNE---LKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEA 150
           SK  I+   + ++Q  N+   +  +A      I+ ++   F QD +         EL E 
Sbjct: 206 SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEE 265

Query: 151 -FKTLHKEYEQLKISGFSTAEIRKDISA-MEEEKDQLIKRVEHLKKRVE----------- 197
            F+ LH E+E+     F   +  +++   +E +K  L  R E +KK +E           
Sbjct: 266 NFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKA 325

Query: 198 TAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAA-- 255
           T ++H+   ++A +  +     E L +QK+++ + L   + R  R +N   S +  A   
Sbjct: 326 TEEDHERTRRLA-EAEMHVHHLESLLEQKEKENSMLREEMHR--RFENAPDSAKTKALQT 382

Query: 256 -----DAKPESL---MKRLEEEI---KFNLYMVTEKFPKELE-------NKKKELHFLQK 297
                D+K  S+   ++ LEEEI   K N  + TE+  +E++       + K   + +++
Sbjct: 383 VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQ 442

Query: 298 VVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEP----IEGKLSLYRQQASIISR 353
           +  E +   +   EL+ K   +  EI Q +++++ R +     ++ KL     Q S   +
Sbjct: 443 LKEELSSKEAQWEELKKKAAGLQAEIGQ-VKQELSRKDTELLALQTKLETLTNQFSDSKQ 501

Query: 354 KKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKK 413
             E   E L   +++ A L+ E    R +  E    E +   + K+  +    K T   +
Sbjct: 502 HIEVLKESLTAKEQRAAILQTEVDALRLRLEE---KETMLNKKTKQIQDMAEEKGTQAGE 558

Query: 414 KHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEE-----KKGISGYSYTQEELERV 468
            H    +LK    + +R   +L+++ EN+Q+QL+  E+     K+ +          +  
Sbjct: 559 IH----DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 614

Query: 469 SALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEK 528
                E    K RT++ + E   +      EK+  + +  K+L+ L++K   L  +  EK
Sbjct: 615 LTTLEEALAEKERTIERLKEQRDR---DEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEK 671

Query: 529 K----------SQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQL 578
           +          S   S     +S    LE  + + +EECL+ ES+      + K  E  L
Sbjct: 672 EASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ------LKKAHEAAL 725

Query: 579 R-RATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAK 637
             RA+ EM   I   ++E  +  +++ +K  AE + L + L+E   V  E +  + K A+
Sbjct: 726 EARASPEMSDRIQHLEREITR-YKDESSKAQAEVDRLLEILKE---VENEKNDKDKKIAE 781

Query: 638 MWRDLEQLMECKKQCFLKQQSQ 659
           + R ++   + KK   LK + Q
Sbjct: 782 LERQVKD--QNKKVANLKHKEQ 801



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 104/484 (21%), Positives = 202/484 (41%), Gaps = 66/484 (13%)

Query: 132  LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEH 191
            LQ +T  +T+     L EA     +  E+LK       +  +D    +EE D   K ++ 
Sbjct: 604  LQADTT-NTDTALTTLEEALAEKERTIERLK------EQRDRDEREKQEEIDNYKKDLKD 656

Query: 192  LKKRVETAQNHQWMLKIARQLRVEKEREEYLAQ---QKQEQKNQLFHAVQRLQ----RVQ 244
            LK++V   Q    + +    L   KE    LA    +K  +   L  A+++ +    +++
Sbjct: 657  LKEKVSLLQGD--LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME 714

Query: 245  NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304
            +QLK   +AA +A+    M    + ++  +    ++  K      + L  L++V +E   
Sbjct: 715  SQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKND 774

Query: 305  GHSDLLELESKINEINTEINQLIEKKMMRNEPI----------EGKLSLYRQQASIISRK 354
                + ELE ++ + N ++  L  K+ +  +            E  L+   QQ     RK
Sbjct: 775  KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 834

Query: 355  KEAKAEELQEA--------KEKLASLEREASVKRNQTREFD----GTEVLKGDEFKRYVN 402
            K+ + EEL+EA         E+   L +E S + N  ++ +      E +K  E +    
Sbjct: 835  KDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK-QELESMKA 893

Query: 403  KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQ 462
            KL S      +K   +  L+AE    +  EE+L+ + E +   +   +    +   S ++
Sbjct: 894  KLSSTQQSLAEKETHLTNLRAE--RRKHLEEVLEMKQEALLAAISEKDANIALLELSSSK 951

Query: 463  EEL-ERVSALKSE----VDEMKGRTLDDMSEMV--------KKLYSLVSEKKSALASVIK 509
            ++  E V+ALK E    V ++K +T + M  M         K  +S  +  K +   +I+
Sbjct: 952  KKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQ 1011

Query: 510  ELRQLRQKYQE-------LTQECDEK-----KSQYDSCAAGLESNRSKLEQEVRRLREEC 557
             L +L Q   +       LT  C ++     +      +  L+ +++  E E++++    
Sbjct: 1012 PLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQ 1071

Query: 558  LQEE 561
            LQ+E
Sbjct: 1072 LQDE 1075


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 99/498 (19%), Positives = 221/498 (44%), Gaps = 87/498 (17%)

Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQ------------NH--QWMLKIARQLRV 214
           A++++ +  +E EK ++   V+ LK+++E A+            +H  + +  ++ +L+ 
Sbjct: 285 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 344

Query: 215 EKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNL 274
           + E  E   +  Q+Q+ +++   +++Q  + +++   +   +   E  ++  EE+++   
Sbjct: 345 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ--EEKIREQEEKMRRQE 402

Query: 275 YMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRN 334
            M+ EK  K    ++      +K+  +  M    + E E KI E+        E+KM   
Sbjct: 403 EMMWEKEEKMRRQEEMMWEKEEKMRRQEEM----MWEKEEKIREL--------EEKMHEQ 450

Query: 335 EPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKG 394
           E I               R++E K +E ++ +E+    E+EA + R + +  +  E ++ 
Sbjct: 451 EKI---------------REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495

Query: 395 DEFK--RYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEK 452
            E K  R   K+  +  + +++ +            Q  EE+ +Q  E I++Q +   +K
Sbjct: 496 QEEKMWRQEEKIHEQEKIREEEKR------------QEQEEMWRQE-EKIREQEEIWRQK 542

Query: 453 KGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELR 512
           + I    + QEE  R    K    E K   + D  E +++    V  ++  +    +++R
Sbjct: 543 EKI----HEQEEKIRKQEEKMWRQEEK---MHDQEEKIREQEEKVWRQEEKIREQEEKIR 595

Query: 513 QLRQKY---QELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNC 569
           +  +K    +E+TQE +EK  + +      E    + E+++RR  E+  ++E +      
Sbjct: 596 EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKK------ 649

Query: 570 MIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESH 629
            I+  E ++R   + M        QE+ + + EQ  K   ++E    K++E+++ +R   
Sbjct: 650 -IREQEEKIREQEEMM--------QEQEEKMWEQEEKMCEQEE----KMQEQEEKMRRQE 696

Query: 630 GPNMKQAKMWRDLEQLME 647
               +Q    R  E+ M+
Sbjct: 697 EKMWEQEVRLRQQEEKMQ 714



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 105/523 (20%), Positives = 231/523 (44%), Gaps = 68/523 (13%)

Query: 149 EAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI 208
           EA   + + ++  K +G    E+ + +SA+  +K +  + +E L K  +        L++
Sbjct: 220 EARDLISRLHDSWKFAG----ELEQALSAVATQKKKADRYIEELTKERDALS-----LEL 270

Query: 209 ARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEE 268
            R    ++E +E  A  K ++K QL  + +    +Q  +K +++    AK          
Sbjct: 271 YRNTITDEELKEKNA--KLQEKLQLVESEK--SEIQLNVKELKRKLERAK---------- 316

Query: 269 EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIE 328
                L +  ++   E ++  KEL  +           S  L+ + + NE+   +NQ  E
Sbjct: 317 -----LLLPQQQLQAEADHLGKELQSV-----------SAKLQAQVEENELWNRLNQQQE 360

Query: 329 KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDG 388
           +KM R E    K+  + +       K + + E+++E +EK+   E+E  ++R +   ++ 
Sbjct: 361 EKMWRQEE---KIQEWEE-------KIQEQEEKIREQEEKIR--EQEEKMRRQEEMMWEK 408

Query: 389 TEVLKGDEFKRYVN--KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQL 446
            E ++  E   +    K+R +  +  +K + I EL+ +    ++  E  ++R E  ++++
Sbjct: 409 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE--EEKI 466

Query: 447 QTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALAS 506
           +  E+++      + QEE  R    K    E K    ++     +K+     EK+     
Sbjct: 467 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIRE--EEKRQEQEE 524

Query: 507 VIKELRQLRQ-----KYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEE 561
           + ++  ++R+     + +E   E +EK  + +      E      E+++R   E+  ++E
Sbjct: 525 MWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE 584

Query: 562 SRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGK---KL 618
            +       I+  E ++R   +EM         E+ + + EQ  K   ++E + +   K+
Sbjct: 585 EKIREQEEKIREQEEKIREQ-EEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKI 643

Query: 619 REKQKVIRESHGPNMKQAKMWRDLEQLM--ECKKQCFLKQQSQ 659
           RE++K IRE      +Q +M ++ E+ M  + +K C  +++ Q
Sbjct: 644 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 686



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 102/485 (21%), Positives = 212/485 (43%), Gaps = 52/485 (10%)

Query: 197 ETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAAD 256
           E   +HQ    + R+L  +      L  QK E +  L+++       Q+ +K +   A D
Sbjct: 171 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYS-------QHAVKQLEGEARD 223

Query: 257 AKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKI 316
                L+ RL +  KF    + +        KKK   +++++  E      D L LE   
Sbjct: 224 -----LISRLHDSWKF-AGELEQALSAVATQKKKADRYIEELTKE-----RDALSLELYR 272

Query: 317 NEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLAS--LER 374
           N I  E  +L EK    N  ++ KL L   + S I    +    +L+ AK  L    L+ 
Sbjct: 273 NTITDE--ELKEK----NAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA 326

Query: 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEEL 434
           EA     + +        + +E + +    + +     ++ + I E + +   +Q  EE 
Sbjct: 327 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK---IQEQEEK 383

Query: 435 LKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLY 494
           ++++ E I++Q + M  ++ +      +E++ R   +  E +E   R  + M E  +K+ 
Sbjct: 384 IREQEEKIREQEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441

Query: 495 SLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLR 554
            L  E+K      I+E  + RQ+ +++ ++  EK+ + ++     E    + E+++R   
Sbjct: 442 EL--EEKMHEQEKIREQEEKRQEEEKIREQ--EKRQEQEAKMWRQEEKIREQEEKIREQE 497

Query: 555 EECLQEESRYHYTNCMIKNLEVQLRRATDEM-----KAYISSDQQEKRKAIREQYTKNTA 609
           E+  ++E + H      K  E + R+  +EM     K     +   +++ I EQ  K   
Sbjct: 498 EKMWRQEEKIHEQE---KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554

Query: 610 EQENLGK---KLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVI 666
           ++E + +   K+ ++++ IRE      ++ K+WR  E++ E +++   +++      ++ 
Sbjct: 555 QEEKMWRQEEKMHDQEEKIRE------QEEKVWRQEEKIREQEEKIREQEEKIREQEEMT 608

Query: 667 QEGGE 671
           QE  E
Sbjct: 609 QEQEE 613



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 96/437 (21%), Positives = 193/437 (44%), Gaps = 50/437 (11%)

Query: 226 KQEQKNQLFHAVQRLQRVQNQLK-SMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKE 284
           K+ ++++L  A ++L     Q   S+  AA+D K + +      E        T      
Sbjct: 114 KETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPET------TTSGGCHS 167

Query: 285 LENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLY 344
            E+++K  H  Q+ +           ELE++++ I     Q  E +M           L 
Sbjct: 168 PEDEQKASHQHQEALRR---------ELEAQVHTIRILTCQKTELQMALYYSQHAVKQLE 218

Query: 345 RQQASIISRKKEAK--AEELQEAKEKLASLEREASVKRNQ-TREFDGTEVLKGDEFKRYV 401
            +   +ISR  ++   A EL++A   +A+ +++A     + T+E D   +   + ++  +
Sbjct: 219 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNTI 275

Query: 402 N--KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENI-----QQQLQTMEEKKG 454
              +L+ K+   ++K Q++   K+E   +Q   + LK++ E       QQQLQ   +  G
Sbjct: 276 TDEELKEKNAKLQEKLQLVESEKSE---IQLNVKELKRKLERAKLLLPQQQLQAEADHLG 332

Query: 455 ISGYSYTQEELERVSA-LKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQ 513
                   +EL+ VSA L+++V+E         +E+  +L     EK       I+E  +
Sbjct: 333 --------KELQSVSAKLQAQVEE---------NELWNRLNQQQEEKMWRQEEKIQEWEE 375

Query: 514 LRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKN 573
             Q+ +E  +E +EK  + +      E    + E+++RR  E   ++E +      M+  
Sbjct: 376 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 435

Query: 574 LEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNM 633
            E ++R   ++M       +QE+++   E+  +    QE   K  R+++K+  +      
Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495

Query: 634 KQAKMWRDLEQLMECKK 650
           ++ KMWR  E++ E +K
Sbjct: 496 QEEKMWRQEEKIHEQEK 512



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 68/388 (17%), Positives = 181/388 (46%), Gaps = 33/388 (8%)

Query: 123 IKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEK 182
           +  ++ ++  ++E     N+Q EE M   +   +E+E+ KI      +IR+    + E++
Sbjct: 338 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE-KIQE-QEEKIREQEEKIREQE 395

Query: 183 DQLIKRVEHLKKRVETAQNHQWML-----KIARQLRVEKEREEYLAQQKQEQKNQLFHAV 237
           +++ ++ E + ++ E  +  + M+     K+ RQ  +  E+EE + + +++   Q    +
Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ--EKI 453

Query: 238 QRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQK 297
           +  +  + + + +R+     + E+ M R EE+I+     + E+  +++  +++++H  +K
Sbjct: 454 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ-EEKMWRQEEKIHEQEK 512

Query: 298 V--------------VSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSL 343
           +                E      ++   + KI+E   +I +  EK   + E +  +   
Sbjct: 513 IREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEK 572

Query: 344 YRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK 403
            R+Q   + R++    E+++E +EK+   E +   +   T+E +     + ++      K
Sbjct: 573 IREQEEKVWRQE----EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 628

Query: 404 LRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTM--EEKKGISGYSYT 461
           ++ +    +++ + I E + +   ++  EE ++++ E +Q+Q + M  +E+K        
Sbjct: 629 MQEQEEKMRRQEEKIREQEKK---IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 685

Query: 462 QEELERVSALKSEVDEMKGRTLDDMSEM 489
           QE+ E++   + ++ E + R      +M
Sbjct: 686 QEQEEKMRRQEEKMWEQEVRLRQQEEKM 713



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 67/330 (20%), Positives = 144/330 (43%), Gaps = 43/330 (13%)

Query: 355 KEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK-LRSKSTVFKK 413
           KE +  +L EAKE+L            QT    GT     D  K+ +N     ++T    
Sbjct: 114 KETRQSKLAEAKEQLTD-------HHPQTNPSVGTAA--SDTKKKKINNGTNPETTTSGG 164

Query: 414 KHQIIAELKAEFGLLQRTEELLKQRHENIQQ-QLQTMEEKKGISGYSYTQEELERVSALK 472
            H    E KA     Q  E L ++    +   ++ T ++ +      Y+Q  +++   L+
Sbjct: 165 CHSPEDEQKASH---QHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQ---LE 218

Query: 473 SEVDEMKGRTLDDMS---EMVKKLYSLVSEKKSA---LASVIKELRQLRQKYQELT---Q 523
            E  ++  R  D      E+ + L ++ ++KK A   +  + KE   L  +    T   +
Sbjct: 219 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE 278

Query: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREEC---------LQEESRYHYTNCMIKNL 574
           E  EK ++       +ES +S+++  V+ L+ +           Q ++   +    ++++
Sbjct: 279 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 338

Query: 575 EVQLRRATDEMKAYISSDQQEKRKAIREQ-----YTKNTAEQENLGKKLREKQKVIRESH 629
             +L+   +E + +   +QQ++ K  R++     + +   EQE   +K+RE+++ IRE  
Sbjct: 339 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQE 395

Query: 630 GPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659
               +Q +M  + E+ M  +++   +++ +
Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 425


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 125/534 (23%), Positives = 225/534 (42%), Gaps = 95/534 (17%)

Query: 146  ELMEAFKTLHKEYEQLKIS---GFST-----AEIRKDISAMEEEKDQLIKRVEHLKKRVE 197
            +L  A  +  +  E+LK+S   G  T     AE++  I  M  +    I+ +++ +    
Sbjct: 580  KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSER 639

Query: 198  TAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV-QRLQRVQNQLKSMRQAAAD 256
             A   +     A+ ++V KE+E  L    +  +++L  A  Q L  +++ L  +++A   
Sbjct: 640  AAHAKEMEALRAKLMKVIKEKENSL----EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 695

Query: 257  AKP-ESLMKRLEEEIKFNLYMVTEKFPKEL---ENKKKELHFLQKVVSEPAMGHSDLLEL 312
             K  E L  +  E+ K     V + F  +L   E K  +L  L+K  SE   G S++ +L
Sbjct: 696  VKELEVLQAKCNEQTK-----VIDNFTSQLKATEEKLLDLDALRKASSE---GKSEMKKL 747

Query: 313  -------ESKINEINTEINQLIEKKMMRNEPIEG---KLSLYRQQASIISRKKEAKAEEL 362
                   E +I  +  E N    K       ++G   KL+  ++  S +S+ KE   +EL
Sbjct: 748  RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 807

Query: 363  QEAKEKLASLEREA-SVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVF-------KKK 414
            Q  KEK A    EA SV+R+                +  VNKL  K   F       +K 
Sbjct: 808  QILKEKFAEASEEAVSVQRSM---------------QETVNKLHQKEEQFNMLSSDLEKL 852

Query: 415  HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474
             + +A+++A+F      EE L +  E ++  +  + +  G           +  S L   
Sbjct: 853  RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG-----------DNSSQLTKM 901

Query: 475  VDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELR-QLRQKYQELTQECDEKKSQYD 533
             DE++ +  D + E+  KL +  +E  S L   I+++  +  Q  QE  ++ +E+K +  
Sbjct: 902  NDELRLKERD-VEELQLKL-TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE-- 957

Query: 534  SCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ 593
                 LE   S LE+++     +C + ++RY               RAT E K       
Sbjct: 958  -----LERKLSDLEKKMETSHNQCQELKARYE--------------RATSETKTKHEEIL 998

Query: 594  QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLME 647
            Q  +K + +   K    +E     L+E +++ +++     K A+   D  Q+ME
Sbjct: 999  QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA--DKAKAAQTAEDAMQIME 1050



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 137/668 (20%), Positives = 261/668 (39%), Gaps = 121/668 (18%)

Query: 27   DSLEPMQLLQVLSDVLAEIDPK-----QLVDIREEMPEQTAKRMLSLLGILKYKPSGNAT 81
            D+L  +Q  ++    L  +  K     +++D      + T +++L L  + K    G + 
Sbjct: 684  DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKS- 742

Query: 82   DMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQD------- 134
            +M   RQ L    K +     H  +++  E  K + + R L   E+    LQ+       
Sbjct: 743  EMKKLRQQLEAAEKQI----KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 798

Query: 135  -------------ETVADTNKQ----YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISA 177
                         E  A+ +++       + E    LH++ EQ  +      ++R++++ 
Sbjct: 799  VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 858

Query: 178  ME-------EEKDQLIKRVEHLKKRVE-----TAQNHQWMLKIARQLRVEKEREEYLAQQ 225
            ME       E ++QLIK  E L+  +      +  N   + K+  +LR+ KER+      
Sbjct: 859  MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL-KERDV----- 912

Query: 226  KQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKEL 285
             +E + +L  A +    +Q  ++ M   A  ++ E+  K  EE  K  L        K++
Sbjct: 913  -EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE--KKELERKLSDLEKKM 969

Query: 286  ENKKKELHFL----QKVVSEPAMGHSD--------LLELESKINEINTEINQLIEK-KMM 332
            E    +   L    ++  SE    H +        LL+ E K+     E + L+++ + +
Sbjct: 970  ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029

Query: 333  RNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVL 392
            R +  + K +   + A  I  +        +E  E LASLE           E D    L
Sbjct: 1030 RKQADKAKAAQTAEDAMQIMEQMT------KEKTETLASLEDTKQTNAKLQNELD---TL 1080

Query: 393  KGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL-----QRTEELLKQRHENIQQQLQ 447
            K +  K  V +L     +   ++Q + E + E   L     Q++++L   + EN++   +
Sbjct: 1081 KENNLKN-VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE 1139

Query: 448  TMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASV 507
                +  ++ +   +EE   ++    E+ + + + + D  E    L   +S   + L   
Sbjct: 1140 LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1199

Query: 508  IKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLR------------- 554
              EL +LR +   L  E    KS + S    LES++ KLE +V+ L              
Sbjct: 1200 DAELEKLRNEVTVLRGENASAKSLH-SVVQTLESDKVKLELKVKNLELQLKENKRQLSSS 1258

Query: 555  ---------EECLQEESRYHYTNCMIKNL---------------EVQLRRATDEMKAYIS 590
                     E+   +ES+  + N +I +L               E  L    D++  Y S
Sbjct: 1259 SGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDS 1318

Query: 591  SDQQEKRK 598
             DQ+++ K
Sbjct: 1319 DDQEKQSK 1326



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 121/593 (20%), Positives = 242/593 (40%), Gaps = 88/593 (14%)

Query: 105 LLQRTNELKKRAYLARFLIKLE-VPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKI 163
           LL +  E K++    +F ++ E +    L+  TV++ ++    +ME  K L    +++  
Sbjct: 427 LLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR----IMELEKDLALRVQEV-- 480

Query: 164 SGFSTAEIRKDISAMEEEKD-----QLIKRVEHLKKRVE-TAQNHQWMLKIARQLRVEKE 217
                AE+R+ + + +   D      L++ +  L++++E T  +HQ      R++   KE
Sbjct: 481 -----AELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ------REITSLKE 529

Query: 218 REEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAA-----------------ADAKPE 260
                 +  Q++   L+ A ++L +    LKS  + A                 A A  +
Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ 589

Query: 261 SLMKRLEEEIKFNLYMVTEKFPK-ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEI 319
             M+ L+      L   T +F + + + +K  L +  ++ +      S+      ++  +
Sbjct: 590 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 649

Query: 320 NTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVK 379
             ++ ++I++K    E I  KL     Q  +   + E    +LQEA+ K+  LE   +  
Sbjct: 650 RAKLMKVIKEKENSLEAIRSKLDKAEDQHLV---EMEDTLNKLQEAEIKVKELEVLQAKC 706

Query: 380 RNQTREFDG-TEVLKGDEFKRY-VNKLRSKSTV----FKKKHQIIAELKAEFGLLQRTEE 433
             QT+  D  T  LK  E K   ++ LR  S+      KK  Q +   + +   L+  + 
Sbjct: 707 NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 766

Query: 434 LLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKL 493
               +  +I ++LQ  E K      +  QE L  VS +K         TL+   +++K+ 
Sbjct: 767 AESSKASSITRELQGRELK-----LTNLQENLSEVSQVKE--------TLEKELQILKEK 813

Query: 494 YSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRL 553
           ++  SE          E   +++  QE   +  +K+ Q++  ++ LE  R  L     + 
Sbjct: 814 FAEASE----------EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 863

Query: 554 REECLQEESRYHYTNCMIKNLEVQLRRATDEMK--AYISSDQQEKRKAIREQYTKNTAEQ 611
           RE+  +EE        +  ++   ++ + D       ++ + + K + + E   K T   
Sbjct: 864 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN 923

Query: 612 EN----------LGKKLREKQKVIRESHGPNMKQ-AKMWRDLEQLMECK-KQC 652
           EN          +  K  + Q+   + H    K+  +   DLE+ ME    QC
Sbjct: 924 ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC 976



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 108/505 (21%), Positives = 211/505 (41%), Gaps = 93/505 (18%)

Query: 162 KISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEY 221
           KISG  T  +++ +   ++  +QL+   +  +  V  A +H            E E+E  
Sbjct: 346 KISG--TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVG----------EIEQELA 393

Query: 222 LAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKF 281
           LA+   +Q       V  L+   +QL++M + AAD +   L+ +LEEE            
Sbjct: 394 LARDGHDQH------VLELEAKMDQLRTMVE-AADREKVELLNQLEEE------------ 434

Query: 282 PKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKL 341
                  K+++  LQ  V E ++   DL            E+  + EK   R   +E  L
Sbjct: 435 -------KRKVEDLQFRVEEESITKGDL------------EVATVSEKS--RIMELEKDL 473

Query: 342 SLYRQQASIISRKKEAK-----AEELQEAKEKLASLEREASVKR-NQTREFDGTEVLKGD 395
           +L  Q+ + + R+ E+       +      ++++SL+ +  V R +  RE    +   G 
Sbjct: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA 533

Query: 396 EFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEE----LLKQRHEN-IQQQLQTME 450
             + +  ++++  T  +K  +    LK++     +       L K + E  I    Q ME
Sbjct: 534 REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME 593

Query: 451 EKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKE 510
           E K +S       E    + LK+++++M+   LD   E    + +L +++ S  A+  KE
Sbjct: 594 ELK-VSFSKGLGTETAEFAELKTQIEKMR---LDYQHE----IENLQNQQDSERAAHAKE 645

Query: 511 LRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCM 570
           +  LR K  ++ +E +            LE+ RSKL++   +   E     ++       
Sbjct: 646 MEALRAKLMKVIKEKEN----------SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 695

Query: 571 IKNLEVQLRRATDEMKAYISSDQQEKR--------KAIREQYTKNTAEQENLGKKLREKQ 622
           +K LEV   +  ++ K   +   Q K          A+R+  ++  +E + L ++L   +
Sbjct: 696 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE 755

Query: 623 KVIR----ESHGPNMKQAKMWRDLE 643
           K I+    E +  + K + + R+L+
Sbjct: 756 KQIKHLEIEKNAESSKASSITRELQ 780


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 125/534 (23%), Positives = 225/534 (42%), Gaps = 95/534 (17%)

Query: 146  ELMEAFKTLHKEYEQLKIS---GFST-----AEIRKDISAMEEEKDQLIKRVEHLKKRVE 197
            +L  A  +  +  E+LK+S   G  T     AE++  I  M  +    I+ +++ +    
Sbjct: 615  KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSER 674

Query: 198  TAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV-QRLQRVQNQLKSMRQAAAD 256
             A   +     A+ ++V KE+E  L    +  +++L  A  Q L  +++ L  +++A   
Sbjct: 675  AAHAKEMEALRAKLMKVIKEKENSL----EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 730

Query: 257  AKP-ESLMKRLEEEIKFNLYMVTEKFPKEL---ENKKKELHFLQKVVSEPAMGHSDLLEL 312
             K  E L  +  E+ K     V + F  +L   E K  +L  L+K  SE   G S++ +L
Sbjct: 731  VKELEVLQAKCNEQTK-----VIDNFTSQLKATEEKLLDLDALRKASSE---GKSEMKKL 782

Query: 313  -------ESKINEINTEINQLIEKKMMRNEPIEG---KLSLYRQQASIISRKKEAKAEEL 362
                   E +I  +  E N    K       ++G   KL+  ++  S +S+ KE   +EL
Sbjct: 783  RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 842

Query: 363  QEAKEKLASLEREA-SVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVF-------KKK 414
            Q  KEK A    EA SV+R+                +  VNKL  K   F       +K 
Sbjct: 843  QILKEKFAEASEEAVSVQRSM---------------QETVNKLHQKEEQFNMLSSDLEKL 887

Query: 415  HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474
             + +A+++A+F      EE L +  E ++  +  + +  G           +  S L   
Sbjct: 888  RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG-----------DNSSQLTKM 936

Query: 475  VDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELR-QLRQKYQELTQECDEKKSQYD 533
             DE++ +  D + E+  KL +  +E  S L   I+++  +  Q  QE  ++ +E+K +  
Sbjct: 937  NDELRLKERD-VEELQLKL-TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE-- 992

Query: 534  SCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ 593
                 LE   S LE+++     +C + ++RY               RAT E K       
Sbjct: 993  -----LERKLSDLEKKMETSHNQCQELKARYE--------------RATSETKTKHEEIL 1033

Query: 594  QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLME 647
            Q  +K + +   K    +E     L+E +++ +++     K A+   D  Q+ME
Sbjct: 1034 QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA--DKAKAAQTAEDAMQIME 1085



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 137/668 (20%), Positives = 261/668 (39%), Gaps = 121/668 (18%)

Query: 27   DSLEPMQLLQVLSDVLAEIDPK-----QLVDIREEMPEQTAKRMLSLLGILKYKPSGNAT 81
            D+L  +Q  ++    L  +  K     +++D      + T +++L L  + K    G + 
Sbjct: 719  DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKS- 777

Query: 82   DMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQD------- 134
            +M   RQ L    K +     H  +++  E  K + + R L   E+    LQ+       
Sbjct: 778  EMKKLRQQLEAAEKQI----KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 833

Query: 135  -------------ETVADTNKQ----YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISA 177
                         E  A+ +++       + E    LH++ EQ  +      ++R++++ 
Sbjct: 834  VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 893

Query: 178  ME-------EEKDQLIKRVEHLKKRVE-----TAQNHQWMLKIARQLRVEKEREEYLAQQ 225
            ME       E ++QLIK  E L+  +      +  N   + K+  +LR+ KER+      
Sbjct: 894  MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL-KERDV----- 947

Query: 226  KQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKEL 285
             +E + +L  A +    +Q  ++ M   A  ++ E+  K  EE  K  L        K++
Sbjct: 948  -EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE--KKELERKLSDLEKKM 1004

Query: 286  ENKKKELHFL----QKVVSEPAMGHSD--------LLELESKINEINTEINQLIEK-KMM 332
            E    +   L    ++  SE    H +        LL+ E K+     E + L+++ + +
Sbjct: 1005 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1064

Query: 333  RNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVL 392
            R +  + K +   + A  I  +        +E  E LASLE           E D    L
Sbjct: 1065 RKQADKAKAAQTAEDAMQIMEQMT------KEKTETLASLEDTKQTNAKLQNELD---TL 1115

Query: 393  KGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL-----QRTEELLKQRHENIQQQLQ 447
            K +  K  V +L     +   ++Q + E + E   L     Q++++L   + EN++   +
Sbjct: 1116 KENNLKN-VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE 1174

Query: 448  TMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASV 507
                +  ++ +   +EE   ++    E+ + + + + D  E    L   +S   + L   
Sbjct: 1175 LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234

Query: 508  IKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLR------------- 554
              EL +LR +   L  E    KS + S    LES++ KLE +V+ L              
Sbjct: 1235 DAELEKLRNEVTVLRGENASAKSLH-SVVQTLESDKVKLELKVKNLELQLKENKRQLSSS 1293

Query: 555  ---------EECLQEESRYHYTNCMIKNL---------------EVQLRRATDEMKAYIS 590
                     E+   +ES+  + N +I +L               E  L    D++  Y S
Sbjct: 1294 SGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDS 1353

Query: 591  SDQQEKRK 598
             DQ+++ K
Sbjct: 1354 DDQEKQSK 1361



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 124/611 (20%), Positives = 246/611 (40%), Gaps = 89/611 (14%)

Query: 105  LLQRTNELKKRAYLARFLIKLE-VPSEFLQDETVADTN--KQYEELMEAFKT----LHKE 157
            LL +  E K++    +F ++ E +    L+ +T  +    K+ E+ +   KT    L +E
Sbjct: 427  LLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRE 486

Query: 158  YEQLKISGFSTA----EIRKDISAMEEEKDQLIKRVEHLK------------KRVETAQN 201
             E  +++  S      E+ KD++   +E  +L +R+E  K            + + + Q 
Sbjct: 487  LEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQE 546

Query: 202  HQWMLKIARQLRVEKEREEYLAQQKQEQKN--QLFHAVQRLQRVQNQLKSMRQAA----- 254
               + +   Q  +   +E + A+++  QK    L+ A ++L +    LKS  + A     
Sbjct: 547  KLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 606

Query: 255  ------------ADAKPESLMKRLEEEIKFNLYMVTEKFPK-ELENKKKELHFLQKVVSE 301
                        A A  +  M+ L+      L   T +F + + + +K  L +  ++ + 
Sbjct: 607  DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 666

Query: 302  PAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEE 361
                 S+      ++  +  ++ ++I++K    E I  KL     Q  +   + E    +
Sbjct: 667  QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLV---EMEDTLNK 723

Query: 362  LQEAKEKLASLEREASVKRNQTREFDG-TEVLKGDEFKRY-VNKLRSKSTV----FKKKH 415
            LQEA+ K+  LE   +    QT+  D  T  LK  E K   ++ LR  S+      KK  
Sbjct: 724  LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLR 783

Query: 416  QIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEV 475
            Q +   + +   L+  +     +  +I ++LQ  E K      +  QE L  VS +K   
Sbjct: 784  QQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELK-----LTNLQENLSEVSQVKE-- 836

Query: 476  DEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSC 535
                  TL+   +++K+ ++  SE          E   +++  QE   +  +K+ Q++  
Sbjct: 837  ------TLEKELQILKEKFAEASE----------EAVSVQRSMQETVNKLHQKEEQFNML 880

Query: 536  AAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMK--AYISSDQ 593
            ++ LE  R  L     + RE+  +EE        +  ++   ++ + D       ++ + 
Sbjct: 881  SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 940

Query: 594  QEKRKAIREQYTKNTAEQEN----------LGKKLREKQKVIRESHGPNMKQ-AKMWRDL 642
            + K + + E   K T   EN          +  K  + Q+   + H    K+  +   DL
Sbjct: 941  RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000

Query: 643  EQLMECK-KQC 652
            E+ ME    QC
Sbjct: 1001 EKKMETSHNQC 1011



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 108/525 (20%), Positives = 219/525 (41%), Gaps = 98/525 (18%)

Query: 162 KISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEY 221
           KISG  T  +++ +   ++  +QL+   +  +  V  A +H            E E+E  
Sbjct: 346 KISG--TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVG----------EIEQELA 393

Query: 222 LAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKF 281
           LA+   +Q       V  L+   +QL++M + AAD +   L+ +LEEE            
Sbjct: 394 LARDGHDQH------VLELEAKMDQLRTMVE-AADREKVELLNQLEEE------------ 434

Query: 282 PKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKL 341
                  K+++  LQ  V E ++   D LE ++K+   +  I +L E+ ++  +    KL
Sbjct: 435 -------KRKVEDLQFRVEEESITKGD-LETQTKLE--HARIKEL-EQSLLFEKTKADKL 483

Query: 342 SLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYV 401
               +   + +  ++++  EL+  K+    ++  A ++R         +V       + +
Sbjct: 484 QRELEDTRVATVSEKSRIMELE--KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEI 541

Query: 402 NKLRSKSTVFKKKHQ-IIAELKAEFGLLQRTE-----------ELLKQRHENIQQQLQTM 449
           + L+ K  V +  HQ  I  LK  FG  + T            E L + +E+++ +L+  
Sbjct: 542 SSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHA 601

Query: 450 EEKK-------------GISGYSYTQEELERVSALK------SEVDEMKGRTLDDMSEMV 490
            ++               I+ +    EEL +VS  K      +E  E+K +      +  
Sbjct: 602 NKENSDVIALWKSKLETAIASHQQAMEEL-KVSFSKGLGTETAEFAELKTQIEKMRLDYQ 660

Query: 491 KKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEV 550
            ++ +L +++ S  A+  KE+  LR K  ++ +E +            LE+ RSKL++  
Sbjct: 661 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN----------SLEAIRSKLDKAE 710

Query: 551 RRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKR--------KAIRE 602
            +   E     ++       +K LEV   +  ++ K   +   Q K          A+R+
Sbjct: 711 DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 770

Query: 603 QYTKNTAEQENLGKKLREKQKVIR----ESHGPNMKQAKMWRDLE 643
             ++  +E + L ++L   +K I+    E +  + K + + R+L+
Sbjct: 771 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQ 815


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.128    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,027,224
Number of Sequences: 37866
Number of extensions: 979001
Number of successful extensions: 12619
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 248
Number of HSP's successfully gapped in prelim test: 1144
Number of HSP's that attempted gapping in prelim test: 5653
Number of HSP's gapped (non-prelim): 4348
length of query: 676
length of database: 18,247,518
effective HSP length: 109
effective length of query: 567
effective length of database: 14,120,124
effective search space: 8006110308
effective search space used: 8006110308
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.