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Search of human proteins with 217416374
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217416374 hypothetical protein LOC92749 [Homo sapiens]
(740 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217416374 hypothetical protein LOC92749 [Homo sapiens] 1451 0.0
gi|224586875 coiled-coil domain containing 65 [Homo sapiens] 84 6e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 76 1e-13
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 74 6e-13
gi|71061468 centromere protein E [Homo sapiens] 72 1e-12
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 70 5e-12
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 70 7e-12
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 70 7e-12
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 70 7e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 69 1e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 69 1e-11
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 69 1e-11
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 69 1e-11
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 69 2e-11
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 68 3e-11
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 67 6e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 67 6e-11
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 67 6e-11
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 67 6e-11
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 67 6e-11
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 67 8e-11
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 66 1e-10
gi|148746195 trichohyalin [Homo sapiens] 66 1e-10
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 65 2e-10
gi|21735548 centrosomal protein 2 [Homo sapiens] 65 2e-10
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 64 5e-10
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 64 7e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 64 7e-10
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 63 9e-10
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens] 63 9e-10
>gi|217416374 hypothetical protein LOC92749 [Homo sapiens]
Length = 740
Score = 1451 bits (3757), Expect = 0.0
Identities = 740/740 (100%), Positives = 740/740 (100%)
Query: 1 MNPPGSLEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLD 60
MNPPGSLEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLD
Sbjct: 1 MNPPGSLEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLD 60
Query: 61 GKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRI 120
GKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRI
Sbjct: 61 GKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRI 120
Query: 121 EKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQ 180
EKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQ
Sbjct: 121 EKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQ 180
Query: 181 ELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASN 240
ELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASN
Sbjct: 181 ELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASN 240
Query: 241 KKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQ 300
KKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQ
Sbjct: 241 KKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQ 300
Query: 301 QLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIK 360
QLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIK
Sbjct: 301 QLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIK 360
Query: 361 QFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVD 420
QFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVD
Sbjct: 361 QFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVD 420
Query: 421 RIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESY 480
RIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESY
Sbjct: 421 RIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESY 480
Query: 481 LDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESE 540
LDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESE
Sbjct: 481 LDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESE 540
Query: 541 DDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEE 600
DDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEE
Sbjct: 541 DDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEE 600
Query: 601 SLVEGEKEEEEETPPSPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSE 660
SLVEGEKEEEEETPPSPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSE
Sbjct: 601 SLVEGEKEEEEETPPSPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSE 660
Query: 661 YWQALTTVIPSSKQNLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLN 720
YWQALTTVIPSSKQNLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLN
Sbjct: 661 YWQALTTVIPSSKQNLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLN 720
Query: 721 SKINSELQVPPTQVLRVPTK 740
SKINSELQVPPTQVLRVPTK
Sbjct: 721 SKINSELQVPPTQVLRVPTK 740
>gi|224586875 coiled-coil domain containing 65 [Homo sapiens]
Length = 484
Score = 83.6 bits (205), Expect = 6e-16
Identities = 65/316 (20%), Positives = 148/316 (46%), Gaps = 1/316 (0%)
Query: 82 KLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKW 141
K+AK L + + Q + E + +E + + +KL E S ++I ++W
Sbjct: 6 KMAKTPLSDEKQLLLFQQKLLAEEEMAKKKERLLSQFLKDKLAKEEHNSALNLNKINTQW 65
Query: 142 EEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDIC 201
++ +EL + + +++ K+ +I L ++L ++QY L+ ++
Sbjct: 66 RTVLREVKTRELHKDIEILSQTFERVVDCKDNVIKSLAKDLSEAEEQYAHALRSHLHNVD 125
Query: 202 LLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNN 261
LL ++ + +++ EL + K FE ER+ ++ ++K+ A E Y+++
Sbjct: 126 QLLALQRHRLSLLEESYNMELEALTKEFETERKTIIDQHEKEIHYLQDIFMAMEQNYIDS 185
Query: 262 RMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQ 321
+ +++ N + + EE + +++ LE V+ L ++ Q Y E + +
Sbjct: 186 EYESKLEFQSMWNDLKNMNLEEKHFLRLHLENRVEDLWRKFQDVLKNYTDATEDRKAAFE 245
Query: 322 VLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFK 381
L+ +DE+S+ Q +KI +L D + + K ++ ++EN+ + +D + +++Q +
Sbjct: 246 TLQVKDEKSSKEIEVQMKKIQKLQDAITISKGKIMIHSRESEDENRYIRNDKELVLVQLR 305
Query: 382 ELQKAMRHFALIDDEK 397
+L KA R A +K
Sbjct: 306 KL-KAQRTQARAASQK 320
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 76.3 bits (186), Expect = 1e-13
Identities = 159/702 (22%), Positives = 300/702 (42%), Gaps = 118/702 (16%)
Query: 91 TELVTNIQVAIDIRE-----IHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEE-G 144
T+ V ++ +D E I + +E + +++E LENE+ + + ++
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
Query: 145 KQKRIPQELWEMLNTQQLHCAGLLEDKNK----LISELQQELKTKDDQYVKDLKKQSDDI 200
K+K ++ E L +LE +N+ +S L+Q + + VKD++K++ +
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL 592
Query: 201 ----------CLLLERMEEQVKNVMKTFRE----------ELYNIEKAFEVERQEL--LA 238
+E + Q+K ++ ++E EL+++EK E+ ++++ L
Sbjct: 593 HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652
Query: 239 SNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMI---KIKLEQDV 295
+K E AL+ N+ ELE N ++KK D K L Q +E + + ++L ++V
Sbjct: 653 ITCEKIE-ALEQENS-ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 296 QILE------QQLQQRKAIYQLNQEKLEYNLQVLK---KRDEESTVIKSQQKRKINRLHD 346
+ L+ QLQ + +E+L+ L++LK K+ E V + RL
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 347 ILNNLRSKYAK---QIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDE--KFWEI 401
L N K + +++ + ENQ+L + + L + K L++ + ++ E + +
Sbjct: 771 TLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830
Query: 402 WLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQI--VE 459
E+E K L +A D + +++ +G + ++ + + +I +
Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNV-------------KIGNLEKENKTLSKEIGIYK 877
Query: 460 EMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLE 519
E +R +E E E K++ ++ T I L+ + L+S L +
Sbjct: 878 ESCVRLKELEKEN------------KELVKRATIDIKTLVT------LREDLVSEKLKTQ 919
Query: 520 QNECYLLRLDAIFSALGIESE---------DDLYKLVNFFLKYRAHRLSSSLQIKPCSQA 570
Q L +L +G+ E DD YKL+ L+ L SL+IK A
Sbjct: 920 QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLE---STLKKSLEIKEEKIA 976
Query: 571 SMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKILE 630
++E A +EE ST +L ++ + + E+L + + EE P N + +
Sbjct: 977 ALE-ARLEE-STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1034
Query: 631 AFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPS--SKQNLWDALYTALEKYH 688
L K +D R+ + R+N+ QAL T + ++ N A AL++
Sbjct: 1035 ETTRELLKVKD-----RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1089
Query: 689 LVL--------TQRAKLLLENSSLEQQNTEL-----QALLQQ 717
+ L TQ AKL +ENS+L Q+T L Q L+QQ
Sbjct: 1090 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ 1131
Score = 56.2 bits (134), Expect = 1e-07
Identities = 149/757 (19%), Positives = 303/757 (40%), Gaps = 83/757 (10%)
Query: 12 PNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSK 71
P+ + +P + S++ + A++ R+E E + +Q
Sbjct: 225 PHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQEL---------EEKTEQLL 275
Query: 72 SYKQK-EESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTS 130
KQ+ E+ ++L +L L+++ + A R+ + E+ + R++KLE+EV
Sbjct: 276 DCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAV---RVDKLESEVSRY 332
Query: 131 QDKFDEI---TSKWEEGKQ-KRIPQELWEMLNTQQLHCAGLLEDKNKLISE-LQQELKTK 185
+++ +I ++ EE K+ ++ E ML Q + ++L E LQ + K
Sbjct: 333 KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLH 392
Query: 186 DDQYVKDL-KKQSDDIC---LLLERMEEQVKNVMKTFREELYNIEKAFEV---------- 231
D + +D+ +K+ +++ + LE ++Q + EL I + E+
Sbjct: 393 DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 452
Query: 232 ERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKL 291
E EL +S K E Q+ K +E L + VE N +I E+ N +L
Sbjct: 453 EVNELTSSRLLKLEMENQS-LTKTVEELRTTVDSVEG-----NASKILKMEKENQ---RL 503
Query: 292 EQDVQILEQQLQQRKAIYQ--------LNQEK--LEYNLQVLKKRDEESTVIKSQQKRKI 341
+ V+ILE ++ Q K Q L +EK LE ++ L++ E I Q+ +
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 342 NRLHDILNNLRSKYAK-QIKQFQEENQSL-------TSDYKRLVMQFKELQKAMRHFALI 393
N+ L A+ ++K ++EN+ L +S ++ + ++++K + H+
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 394 DDE-KFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQK 452
+ + E L + E+ +L+ + +I L N+ + K
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE-------NSELERENRKLK 676
Query: 453 SATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLL 512
+ + + E E E + + E+ L+L + + + M +ES+
Sbjct: 677 KTLDSFKNLTFQLESLEKENSQLDEEN-LELRRNVESLKCASMKMAQLQLENKELESEKE 735
Query: 513 SLLLPLEQNECYLL---RLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQ 569
L LE + RL+ + L IE++ L N K + +L S LQ
Sbjct: 736 QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ--QLESELQDLEMEN 793
Query: 570 ASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKIL 629
+++K E + LE E+ E+E S +E +K++ E+ N L+
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK---------ENKRLR-Q 843
Query: 630 EAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDALYTALEKYHL 689
+A + ++ ++K + SK+ ++ + ++ + + A
Sbjct: 844 QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903
Query: 690 VLTQRAKLLLENSSLEQQNTELQALLQQYLNSKINSE 726
++T R L+ E +Q N +L+ L + +N E
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Score = 46.2 bits (108), Expect = 1e-04
Identities = 86/392 (21%), Positives = 163/392 (41%), Gaps = 71/392 (18%)
Query: 8 EALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEE 67
EAL DE Q P DN ER R +++ R E E
Sbjct: 1004 EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV-----------ER 1052
Query: 68 DQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIE-KLENE 126
+ + +K+ + +L +L L I +A+ + + + + ++ Q + ++EN
Sbjct: 1053 NNATLQAEKQALKTQLKQLETQNNNLQAQI-LALQRQTVSLQEQNTTLQTQNAKLQVENS 1111
Query: 127 VKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKD 186
SQ TS + Q I Q LE++N+ + + +++LK+
Sbjct: 1112 TLNSQS-----TSLMNQNAQLLIQQSS--------------LENENESVIKEREDLKSLY 1152
Query: 187 DQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQ 246
D +KD +K + LL ER + ++++ L + K EVE ++L + ++ Q
Sbjct: 1153 DSLIKDHEK----LELLHERQASEYESLISK-HGTLKSAHKNLEVEHRDL----EDRYNQ 1203
Query: 247 ALQAHNAKELEYLNNRMKKVEDYEKQL--NRQRIWDCEEY----------NMIKIKLEQD 294
L+ +LE L +M KVE EK L N+ EY N +L ++
Sbjct: 1204 LLKQKG--QLEDL-EKMLKVEQ-EKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1259
Query: 295 VQILEQQLQQRKAIY---QLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNL 351
++L+ + K++ +L Q +LE LK++ ++ + + K+N ++L+ L
Sbjct: 1260 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST----KLNNQCELLSQL 1315
Query: 352 RSKYAKQIKQFQEENQSLTSDYKRLVMQFKEL 383
+ +EEN+ L + L++Q + L
Sbjct: 1316 KG-------NLEEENRHLLDQIQTLMLQNRTL 1340
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 73.6 bits (179), Expect = 6e-13
Identities = 158/703 (22%), Positives = 299/703 (42%), Gaps = 119/703 (16%)
Query: 91 TELVTNIQVAIDIRE-----IHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEE-G 144
T+ V ++ +D E I + +E + +++E LENE+ + + ++
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
Query: 145 KQKRIPQELWEMLNTQQLHCAGLLEDKNK----LISELQQELKTKDDQYVKDLKKQSDDI 200
K+K ++ E L +LE +N+ +S L+Q + + VKD++K++ +
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL 592
Query: 201 ----------CLLLERMEEQVKNVMKTFRE----------ELYNIEKAFEVERQEL--LA 238
+E + Q+K ++ ++E EL+++EK E+ ++++ L
Sbjct: 593 HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652
Query: 239 SNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMI---KIKLEQDV 295
+K E AL+ N+ ELE N ++KK D K L Q +E + + ++L ++V
Sbjct: 653 ITCEKIE-ALEQENS-ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 296 QILE------QQLQQRKAIYQLNQEKLEYNLQVLK---KRDEESTVIKSQQKRKINRLHD 346
+ L+ QLQ + +E+L+ L++LK K+ E V + RL
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 347 ILNNLRSKYAK---QIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDE--KFWEI 401
L N K + +++ + ENQ+L + + L + K L++ + ++ E + +
Sbjct: 771 TLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830
Query: 402 WLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQI--VE 459
E+E K L +A D + +++ +G + ++ + + +I +
Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNV-------------KIGNLEKENKTLSKEIGIYK 877
Query: 460 EMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLE 519
E +R +E E E K++ ++ T I L+ + L+S L +
Sbjct: 878 ESCVRLKELEKEN------------KELVKRATIDIKTLVT------LREDLVSEKLKTQ 919
Query: 520 QNECYLLRLDAIFSALGIESE----------DDLYKLVNFFLKYRAHRLSSSLQIKPCSQ 569
Q L +L +G+ E D YKL+ L+ L SL+IK
Sbjct: 920 QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE---STLKKSLEIKEEKI 976
Query: 570 ASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKIL 629
A++E A +EE ST +L ++ + + E+L + + EE P N +
Sbjct: 977 AALE-ARLEE-STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1034
Query: 630 EAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPS--SKQNLWDALYTALEKY 687
+ L K +D R+ + R+N+ QAL T + ++ N A AL++
Sbjct: 1035 QETTRELLKVKD-----RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
Query: 688 HLVL--------TQRAKLLLENSSLEQQNTEL-----QALLQQ 717
+ L TQ AKL +ENS+L Q+T L Q L+QQ
Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ 1132
Score = 56.2 bits (134), Expect = 1e-07
Identities = 149/757 (19%), Positives = 303/757 (40%), Gaps = 83/757 (10%)
Query: 12 PNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSK 71
P+ + +P + S++ + A++ R+E E + +Q
Sbjct: 225 PHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQEL---------EEKTEQLL 275
Query: 72 SYKQK-EESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTS 130
KQ+ E+ ++L +L L+++ + A R+ + E+ + R++KLE+EV
Sbjct: 276 DCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAV---RVDKLESEVSRY 332
Query: 131 QDKFDEI---TSKWEEGKQ-KRIPQELWEMLNTQQLHCAGLLEDKNKLISE-LQQELKTK 185
+++ +I ++ EE K+ ++ E ML Q + ++L E LQ + K
Sbjct: 333 KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLH 392
Query: 186 DDQYVKDL-KKQSDDIC---LLLERMEEQVKNVMKTFREELYNIEKAFEV---------- 231
D + +D+ +K+ +++ + LE ++Q + EL I + E+
Sbjct: 393 DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 452
Query: 232 ERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKL 291
E EL +S K E Q+ K +E L + VE N +I E+ N +L
Sbjct: 453 EVNELTSSRLLKLEMENQS-LTKTVEELRTTVDSVEG-----NASKILKMEKENQ---RL 503
Query: 292 EQDVQILEQQLQQRKAIYQ--------LNQEK--LEYNLQVLKKRDEESTVIKSQQKRKI 341
+ V+ILE ++ Q K Q L +EK LE ++ L++ E I Q+ +
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 342 NRLHDILNNLRSKYAK-QIKQFQEENQSL-------TSDYKRLVMQFKELQKAMRHFALI 393
N+ L A+ ++K ++EN+ L +S ++ + ++++K + H+
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 394 DDE-KFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQK 452
+ + E L + E+ +L+ + +I L N+ + K
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE-------NSELERENRKLK 676
Query: 453 SATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLL 512
+ + + E E E + + E+ L+L + + + M +ES+
Sbjct: 677 KTLDSFKNLTFQLESLEKENSQLDEEN-LELRRNVESLKCASMKMAQLQLENKELESEKE 735
Query: 513 SLLLPLEQNECYLL---RLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQ 569
L LE + RL+ + L IE++ L N K + +L S LQ
Sbjct: 736 QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ--QLESELQDLEMEN 793
Query: 570 ASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKIL 629
+++K E + LE E+ E+E S +E +K++ E+ N L+
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK---------ENKRLR-Q 843
Query: 630 EAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDALYTALEKYHL 689
+A + ++ ++K + SK+ ++ + ++ + + A
Sbjct: 844 QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903
Query: 690 VLTQRAKLLLENSSLEQQNTELQALLQQYLNSKINSE 726
++T R L+ E +Q N +L+ L + +N E
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Score = 46.2 bits (108), Expect = 1e-04
Identities = 86/392 (21%), Positives = 163/392 (41%), Gaps = 71/392 (18%)
Query: 8 EALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEE 67
EAL DE Q P DN ER R +++ R E E
Sbjct: 1005 EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV-----------ER 1053
Query: 68 DQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIE-KLENE 126
+ + +K+ + +L +L L I +A+ + + + + ++ Q + ++EN
Sbjct: 1054 NNATLQAEKQALKTQLKQLETQNNNLQAQI-LALQRQTVSLQEQNTTLQTQNAKLQVENS 1112
Query: 127 VKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKD 186
SQ TS + Q I Q LE++N+ + + +++LK+
Sbjct: 1113 TLNSQS-----TSLMNQNAQLLIQQSS--------------LENENESVIKEREDLKSLY 1153
Query: 187 DQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQ 246
D +KD +K + LL ER + ++++ L + K EVE ++L + ++ Q
Sbjct: 1154 DSLIKDHEK----LELLHERQASEYESLISK-HGTLKSAHKNLEVEHRDL----EDRYNQ 1204
Query: 247 ALQAHNAKELEYLNNRMKKVEDYEKQL--NRQRIWDCEEY----------NMIKIKLEQD 294
L+ +LE L +M KVE EK L N+ EY N +L ++
Sbjct: 1205 LLKQKG--QLEDL-EKMLKVEQ-EKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1260
Query: 295 VQILEQQLQQRKAIY---QLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNL 351
++L+ + K++ +L Q +LE LK++ ++ + + K+N ++L+ L
Sbjct: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST----KLNNQCELLSQL 1316
Query: 352 RSKYAKQIKQFQEENQSLTSDYKRLVMQFKEL 383
+ +EEN+ L + L++Q + L
Sbjct: 1317 KG-------NLEEENRHLLDQIQTLMLQNRTL 1341
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 72.4 bits (176), Expect = 1e-12
Identities = 159/735 (21%), Positives = 315/735 (42%), Gaps = 95/735 (12%)
Query: 30 DNSQERIQARRLRIAARLEARRREALG---EYLDGKKESEEDQSKSYKQKEESRLKLAKL 86
D++ RI+ L ++ RL+ E E D ++ E QS+S + KE + +AK
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 87 LLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIE--KLENEVKTSQDKFDEITSKWEEG 144
L EL + + +EE I R+ + E E+ T Q + + I K +
Sbjct: 1473 LETEEEL--------KVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNK 1524
Query: 145 KQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLL 204
Q+ +E E N +Q+ +++K + + ++ K KD ++ ++ + ++ L
Sbjct: 1525 IQEIYEKE--EQFNIKQI---SEVQEKVNELKQFKEHRKAKDSA-LQSIESKMLELTNRL 1578
Query: 205 ERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMK 264
+ +E+++ ++K +EE+ +++A ++ER +L + K E + ++E EY +M
Sbjct: 1579 QESQEEIQIMIKE-KEEMKRVQEALQIERDQLKENTK---EIVAKMKESQEKEYQFLKMT 1634
Query: 265 KVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLK 324
V + ++++ C E +K + E LE + + Q+ E LE V K
Sbjct: 1635 AVNETQEKM-------C-EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTK 1686
Query: 325 KRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQ 384
+RD+ +V ++ K+ R + NLR + +++ +E K + M KE Q
Sbjct: 1687 ERDDLRSV---EETLKVER-DQLKENLRETITRDLEKQEE--------LKIVHMHLKEHQ 1734
Query: 385 KAMRHFALIDDEKFWEIWLMNE--EEAKD-LIARAFDVDRIIHTHHLGLPWAAPDFWFLN 441
+ + I EK EI M + E + D L A+ + + H+ L L
Sbjct: 1735 ETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR 1794
Query: 442 NVGPISQQPQK-SATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTK-----RI 495
G +S++ K S Q E +E+ +E A + L K ++E K ++
Sbjct: 1795 --GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQL 1852
Query: 496 LMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRA 555
+ D+S L + ++ +L L + +E L+ + S + E D + V LK
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHE----NLEEMKSVM---KERDNLRRVEETLKLER 1905
Query: 556 HRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPP 615
+L SLQ + + + EL+ A + E +E++ + ++ E+T
Sbjct: 1906 DQLKESLQ----------ETKARDLEIQQELKTARM--LSKEHKETVDKLREKISEKT-- 1951
Query: 616 SPWVIHPNDVLKILEAFVMGLKK-----PRDSRAPLRVQKNVRDNSKD-------SEYWQ 663
I +D+ K L+ L+K + LRV+++V + K + ++
Sbjct: 1952 ----IQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFE 2007
Query: 664 ALTTVIPSSKQN---LWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLN 720
A + S + + L L+ +LE+ +V +R +L SL+ + + A L++ +
Sbjct: 2008 AQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMI- 2066
Query: 721 SKINSELQVPPTQVL 735
++ QV P + L
Sbjct: 2067 ARDRQNHQVKPEKRL 2081
Score = 71.6 bits (174), Expect = 2e-12
Identities = 107/563 (19%), Positives = 246/563 (43%), Gaps = 65/563 (11%)
Query: 91 TELVTNIQVAIDIREIHRRVEEEEIKRQRIE--------KLENEVKTSQDKFDEITSKWE 142
T+L NI++ I+ +E R + +E K+Q I K E E+ + D+ E+ K +
Sbjct: 1071 TDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLK 1130
Query: 143 EGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICL 202
E K +++ ++ ++LN Q+ ++ K I L+ ELK K + ++ ++ + ++
Sbjct: 1131 E-KSQQLQEKQQQLLNVQEE--MSEMQKKINEIENLKNELKNK-ELTLEHMETERLELAQ 1186
Query: 203 LLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNR 262
L E+VK++ K R+ L ++K+FE ER L ++ LQ +EL+ +
Sbjct: 1187 KLNENYEEVKSITKE-RKVLKELQKSFETERDHLRGYIREIEATGLQ--TKEELKIAHIH 1243
Query: 263 MKKVEDYEKQLNRQ------RIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKL 316
+K+ ++ +L R +I + ++ KL++++ +L ++ + + ++++
Sbjct: 1244 LKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE--T 1301
Query: 317 EYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRL 376
+ + L+ E+ST S +I LN + ++IK +E +L + + L
Sbjct: 1302 QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL 1361
Query: 377 VMQFKELQKAMRH-FALI----------------DDEKFWEIWLMNEEEAKDLIARAFDV 419
++ +L++ +R A I D+E + M + + KD ++
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI 1421
Query: 420 DRI-----IHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAA 474
+ + + H + A + L + + Q + ++E++ + E E E
Sbjct: 1422 EMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKV 1481
Query: 475 A------EPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRL 528
A + E+ +L +SEK T+ + + I KL + + + + E
Sbjct: 1482 AHCCLKEQEETINELRVNLSEKETE---ISTIQKQLEAINDKLQNKIQEIYEKE------ 1532
Query: 529 DAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKAS-MEETSTRSELE 587
I+ ++ + VN +++ HR + ++ +E + ++E+ ++
Sbjct: 1533 ----EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
Query: 588 LAEQTEMEGEKEESLVEGEKEEE 610
+ E+ EM+ +E +E ++ +E
Sbjct: 1589 IKEKEEMKRVQEALQIERDQLKE 1611
Score = 55.5 bits (132), Expect = 2e-07
Identities = 84/374 (22%), Positives = 157/374 (41%), Gaps = 73/374 (19%)
Query: 59 LDGKKESEEDQSKSYKQKEESRLKLAKL--------LLCGTEL---VTNIQVAIDIREIH 107
L+ KK+ + D K + KL L LLC EL +T++Q +E++
Sbjct: 676 LEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQ-----KELN 730
Query: 108 RRVEEEEIKRQRI-------------EKLENEVKTSQDKFDEITSKWEEGKQKRIPQELW 154
+ VEE E R+ + E+L E++ ++ ITS+ ++ L+
Sbjct: 731 KEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDK---------LF 781
Query: 155 EMLNTQQLHCAGLLEDKNKLISEL---QQELKTKDDQYVK------DLKKQSDDICLLLE 205
+ ++ GLLE+ K +L Q K+ D ++ D +++ + E
Sbjct: 782 SEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENE 841
Query: 206 RMEEQVKNVMKT---FREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKE-LEYLNN 261
RM +++ N+ K F L ++ + QEL ++ E+ + KE LE ++
Sbjct: 842 RMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDS 901
Query: 262 RMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLN--------- 312
++ VE EK L +++ E + + D++ L++ LQ + + +
Sbjct: 902 TLQTVER-EKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
Query: 313 --QEKLEYNLQVLKKRDEESTVIKSQQKRKINR-LHDILNNLRSKYAKQIKQF------- 362
QE+L L+ LK+ E +KS+ +++R LH N +K Q K
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Query: 363 --QEENQSLTSDYK 374
+ Q+LT+D K
Sbjct: 1021 LEAKNTQTLTADVK 1034
Score = 52.4 bits (124), Expect = 2e-06
Identities = 132/647 (20%), Positives = 261/647 (40%), Gaps = 122/647 (18%)
Query: 33 QERIQARRLR----IAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLL 88
QE+IQ + I + + + ++ K+ +DQS + + E L LA+ L
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL- 1877
Query: 89 CGTELVTNIQVAIDIREIHRRVEEE-EIKRQRIEKLENEVKTSQDKFDEI--TSKWEEGK 145
E + ++ + R+ RRVEE +++R ++++ E K + + T++ +
Sbjct: 1878 --HENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKE 1935
Query: 146 QKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQ---QELKTKDDQYVK----------- 191
K +L E ++ + + + + +D +K ELQ QEL+ K+ Q ++
Sbjct: 1936 HKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKK 1995
Query: 192 -----DLKKQ--SDDICLLLERME------------EQVKNVMKTFREELYNIEKAFEVE 232
LKKQ + ++ + RM+ E+++ V K R+EL I+++ ++E
Sbjct: 1996 INEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE-RDELRRIKESLKME 2054
Query: 233 RQELLASNKKKWEQALQAHNAKE------------LEYLNNRMKKVEDYEKQLNR-QRIW 279
R + +A+ ++ + Q H K E L + ++++ K+ + +
Sbjct: 2055 RDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY 2114
Query: 280 DCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKR 339
+C N + + LE++++ +++L R K +L L+ + E +Q R
Sbjct: 2115 EC--LNRLSLDLEKEIE-FQKELSMR--------VKANLSLPYLQTKHIEKLFTANQ--R 2161
Query: 340 KINRLHDILNNLR--SKYAKQIKQFQEEN-QSLTSDYKRLVMQFKELQKAMRHFALIDDE 396
H I+ L+ Y +IK+ Q E+ D+ V + KEL ++H D
Sbjct: 2162 CSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD- 2220
Query: 397 KFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQ 456
+ E +DL + + +H + ++ +F + +K TQ
Sbjct: 2221 -------VPSRELRDL---KLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQ 2270
Query: 457 IVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLL 516
+EE L + E + + E+ D Q++ RI+ ++ + + F S +S
Sbjct: 2271 FLEEWLNTRFDIEKLKNGIQKEN--DRICQVNNFFNNRIIAIMNESTEFEERSATISK-- 2326
Query: 517 PLEQNECYLLRLDAIFSALGIESEDDLYKL----VNFFLKYRAHR--LSSSLQIKPCSQA 570
E E DL L F Y+ + L+S Q+ P +Q
Sbjct: 2327 ---------------------EWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQD 2365
Query: 571 S-----MEKASMEETSTRSELE--LAEQTEMEGEKEESLVEGEKEEE 610
+ +A+ T ELE L E E KE +++ +KE E
Sbjct: 2366 NKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELE 2412
Score = 51.6 bits (122), Expect = 3e-06
Identities = 81/397 (20%), Positives = 167/397 (42%), Gaps = 76/397 (19%)
Query: 62 KKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIE 121
KKE E ++ + E +LK +L Q ++++E + E + K IE
Sbjct: 1110 KKEGELSRTCDRLAEVEEKLKEKS-----QQLQEKQQQLLNVQE---EMSEMQKKINEIE 1161
Query: 122 KLENEVKTSQDKFD-------EITSKWEEG--------KQKRIPQELWEMLNTQQLHCAG 166
L+NE+K + + E+ K E K++++ +EL + T++ H G
Sbjct: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1221
Query: 167 LLEDKNKLISELQQELK-----TKDDQYVKDLKKQS-----------DDICLLLERMEEQ 210
+ + + ++ELK K+ Q D ++S D+ +++E+
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE 1281
Query: 211 VKNVMKTFREELYNIEKAFEVERQ----ELLASNKKKWEQALQAHNAKELEYLNNRMKKV 266
+ V+ +E L N+++ E + ELL + A E LN + ++
Sbjct: 1282 IP-VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQES 1340
Query: 267 EDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKR 326
++ K L ++R + IK LE L++ +++ A Q +Q K E +L +K++
Sbjct: 1341 QEEIKSLTKER----DNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN-MKEK 1395
Query: 327 DEESTVIKSQQK--------------------RKINRLHDILNNLRSKYAKQIKQFQE-- 364
D E+T I S+ + +++ HD + ++ +K +++ QE
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV-AKEKDDLQRLQEVL 1454
Query: 365 --ENQSLTSDYKRLVMQFKELQKAMR--HFALIDDEK 397
E+ L + K +V + E ++ ++ H L + E+
Sbjct: 1455 QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEE 1491
Score = 40.4 bits (93), Expect = 0.006
Identities = 65/316 (20%), Positives = 130/316 (41%), Gaps = 56/316 (17%)
Query: 121 EKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQ 180
E +E+E+ + + +D + +E+ + ++ EL L++KN L
Sbjct: 494 ENIESELNSLRADYDNLVLDYEQLRTEKEEMEL-------------KLKEKNDLDEFEAL 540
Query: 181 ELKTKDDQ--------------------YVKDLKKQSDDICLLLERMEEQVKNVMKTF-R 219
E KTK DQ Y +DL+ + LL E+Q+K + +
Sbjct: 541 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS 600
Query: 220 EELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIW 279
++L NI+ + + + K+ +Q L L+ K+ + + N +
Sbjct: 601 QKLENIKMDLSYSLESI--EDPKQMKQTLFDAETVALD-----AKRESAFLRSENLELKE 653
Query: 280 DCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKR 339
+E ++E D+Q+ + QL+ +K + Q++ EK L+ E T + S
Sbjct: 654 KMKELATTYKQMENDIQLYQSQLEAKKKM-QVDLEK------ELQSAFNEITKLTSLIDG 706
Query: 340 KINRLHDILNNLR-----SKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALID 394
K+ + D+L NL + K++ + EEN++L + L+ + K L +
Sbjct: 707 KVPK--DLLCNLELEGKITDLQKELNKEVEENEALREEV-ILLSELKSLPSEVERLRKEI 763
Query: 395 DEKFWEIWLMNEEEAK 410
+K E+ ++ E+ K
Sbjct: 764 QDKSEELHIITSEKDK 779
Score = 30.8 bits (68), Expect = 4.7
Identities = 53/267 (19%), Positives = 116/267 (43%), Gaps = 27/267 (10%)
Query: 116 KRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLI 175
K +++ K +KTS ++ ++ K + + L T+++ LE+
Sbjct: 2338 KNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQ-LTTEKIR---ELENSLHEA 2393
Query: 176 SELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQE 235
E ++K + K+L+ +D I L ++ E K + KT ++ +V Q+
Sbjct: 2394 KESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKT--------KETIQV-LQD 2444
Query: 236 LLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDV 295
+A K +++ ++ K ++ +MK +++EK+++ + EY I+L ++
Sbjct: 2445 KVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKA--TVEYQKEVIRLLREN 2502
Query: 296 QILEQQLQQRKAIY-----QLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNN 350
QQ Q I Q + + L ++ ++ ++KS+ RL ++
Sbjct: 2503 LRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEH----IRLEKEISK 2558
Query: 351 LRSKYAKQIKQFQE---ENQSLTSDYK 374
L+ + + IKQ E NQ L+++ K
Sbjct: 2559 LKQQNEQLIKQKNELLSNNQHLSNEVK 2585
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 70.5 bits (171), Expect = 5e-12
Identities = 147/746 (19%), Positives = 294/746 (39%), Gaps = 118/746 (15%)
Query: 1 MNPPGSLEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLD 60
M P SL D+H ++I + D + ++A+ +L+ + + + L+
Sbjct: 231 MTPKFSLRKSSSFHDDHFLSRIREKEL--DMKTKMMEAKFHEEKLKLQQKHDADVQKILE 288
Query: 61 GKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRI 120
K E+ Y+ K+ + + +L +Q I ++ R +E++I +
Sbjct: 289 RKNNEIEELKTLYRSKQHETEETIR------KLEKKVQTLIRDCQVIRETKEDQIAELK- 341
Query: 121 EKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAG---LLEDKNKLISE 177
K + + + + WE+ + + E + Q+ H LLED N +++
Sbjct: 342 -------KICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNK 394
Query: 178 LQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELL 237
++ E Y+ + + I L R+++ + + I++ E+ER +
Sbjct: 395 MESE-------YMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQI 447
Query: 238 ASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQI 297
++ + +A + KE ++L V DYE+ + +++ K + D+ +
Sbjct: 448 TCSELQEVKARRNTLHKEKDHL------VNDYEQNM-----------KLLQTKYDADINL 490
Query: 298 LEQQ--LQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKR-KINRLHDILNNLRSK 354
L+Q+ L KA + E+LE N+ LK++ +ES + + QQ R + N+ ++L+
Sbjct: 491 LKQEHALSASKASSMI--EELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHI 548
Query: 355 YAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIA 414
Y K+ Q E D ++ + +F+E K E ++ +
Sbjct: 549 YEKKAHDLQSELDKGKEDTQKKIHKFEEALK----------------------EKEEQLT 586
Query: 415 RAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAE--E 472
R +V R+ +QQ + + ++ + SE+ AE E
Sbjct: 587 RVTEVQRL-----------------------QAQQADAALEEFKRQVELNSEKVYAEMKE 623
Query: 473 AAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRL-DAI 531
+ E+ L K + EK +K L L ++ E +++ L L EQ + +LL+ +A
Sbjct: 624 QMEKVEADLTRSKSLREKQSKEFLWQL-EDIRQRYEQQIVELKLEHEQEKTHLLQQHNAE 682
Query: 532 FSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQ 591
+L + E ++ L + RA + QI+ + + + E E E
Sbjct: 683 KDSLVRDHEREIENLEK---QLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLRE--EL 737
Query: 592 TEMEGEKEESLVEGE--KEEEEETPPSPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQ 649
+ ++++ LVE +EEE++ I N + E + LKK + + ++
Sbjct: 738 INVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLE 797
Query: 650 K-NVRDNSKDSEYWQALT----------TVIPSSKQNLWDALYTALEKYHLVLTQRAKLL 698
K N + + EY Q L T I S K+ A + V R K
Sbjct: 798 KANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDV---RQKFE 854
Query: 699 LENSSLEQQNTELQALLQQYLNSKIN 724
E L + N + +LQ L ++ N
Sbjct: 855 DEKKQLIRDNDQAIKVLQDELENRSN 880
Score = 40.0 bits (92), Expect = 0.008
Identities = 41/258 (15%), Positives = 123/258 (47%), Gaps = 11/258 (4%)
Query: 16 EHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEED--QSKSY 73
E+L Q+ A ++ +N + + R ++ A +EA+ + E ++ + ++ +
Sbjct: 695 ENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLL 754
Query: 74 KQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKR--QRIEKLENEVKTSQ 131
+++E+ R ++ + ++ I++++ H E +++ +++++E E
Sbjct: 755 REEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKL 814
Query: 132 DKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVK 191
K +I ++ + L E + QQL L+D + + +++L +DQ +K
Sbjct: 815 AKSSQIIAELQT-----TISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIK 869
Query: 192 DLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELL-ASNKKKWEQALQA 250
L+ + ++ + E+++++ +E++ I + +E + + L+ AS +++ E + +
Sbjct: 870 VLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISS 929
Query: 251 HNAKELEYLNNRMKKVED 268
+ ++ +L R +++
Sbjct: 930 LKS-QVNFLQKRASILQE 946
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 70.1 bits (170), Expect = 7e-12
Identities = 86/416 (20%), Positives = 191/416 (45%), Gaps = 60/416 (14%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
Q+++QA + L++ + L + E E ++ +Q+EE + + + E
Sbjct: 260 QQQLQAEADHLGKELQS-----VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE 314
Query: 93 LVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWE-EGKQKRIPQ 151
+ + I RE ++ E+E K +R E++ E + + +E+ WE E K +R+ +
Sbjct: 315 KIQEQEEKI--REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM--WEKEEKMRRLEE 370
Query: 152 ELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQV 211
+WE ++ L E ++ +QE K ++++ +++ +K+ + + R EE++
Sbjct: 371 MMWE----KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW-RQEEKI 425
Query: 212 KNVMKTFREE----------LYNIEKAFEVER----------QELLASNKKKWEQALQAH 251
+ + RE+ ++ EK E E+ +E + ++ W Q + H
Sbjct: 426 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMH 485
Query: 252 NAKELEYLNNRM----KKVEDYEKQLNRQ--RIWDCEEYNMIKIKLEQDVQILEQQ--LQ 303
+++ ++ +K+ D E+++ Q ++W EE KI+ EQ+ +I EQ+ ++
Sbjct: 486 EQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEE----KIR-EQEEKIREQEEKIR 540
Query: 304 QRKAIYQLNQEKL---EYNLQVLKKRDEESTVIKSQ------QKRKINRLHDILNNLRSK 354
+++ + Q +EK+ E +Q +K + I+ Q QK KI + + K
Sbjct: 541 EQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEK 600
Query: 355 YAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFW--EIWLMNEEE 408
+Q + QE+ + + +++ Q +++Q+ +EK W E+ L +EE
Sbjct: 601 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR-QEEKMWEQEVRLRQQEE 655
Score = 68.9 bits (167), Expect = 2e-11
Identities = 75/378 (19%), Positives = 173/378 (45%), Gaps = 56/378 (14%)
Query: 64 ESEEDQSKSYKQKEESRLKLAKLLL-----------CGTELVT---NIQVAIDIREIHRR 109
ESE+ + + ++ + +L+ AKLLL G EL + +Q ++ E+ R
Sbjct: 234 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 293
Query: 110 V---EEEEIKRQ---------RIEKLENEVKTSQDKFDEITSK--------WE-EGKQKR 148
+ +EE++ RQ +I++ E +++ ++K E K WE E K +R
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353
Query: 149 IPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERME 208
+ +WE + ++ +K + I EL++++ ++ ++ K+Q ++ E+ +
Sbjct: 354 QEEMMWEK-EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 412
Query: 209 EQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVED 268
EQ +++ E+ + +++ KK W Q + H +++ R ++ E
Sbjct: 413 EQ--------EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 464
Query: 269 Y---EKQLNRQRIWDCEE--YNMIKI-KLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQV 322
+ EK ++ IW +E + KI K E+ V E+++ ++ + +EK+ +
Sbjct: 465 WRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEK 524
Query: 323 LKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKE 382
+++++E+ +Q+ KI +++ K +Q ++ QE+ + + K + + +E
Sbjct: 525 IREQEEKI----REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEK--IREQEE 578
Query: 383 LQKAMRHFALIDDEKFWE 400
+ + +EK WE
Sbjct: 579 KIREQKEKIREQEEKIWE 596
Score = 56.2 bits (134), Expect = 1e-07
Identities = 67/349 (19%), Positives = 166/349 (47%), Gaps = 51/349 (14%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
+E+I+ + +I + E RR+ E + K+E Q + +KEE +L +++ E
Sbjct: 320 EEKIREQEEKIREQEEKMRRQE--EMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE 377
Query: 93 LVTNIQVAIDIREIHRRVEEEEIKRQRIEKL----------------ENEVKTSQDKFDE 136
+ ++ + +E ++ E+E KRQ EK+ E +++ ++K E
Sbjct: 378 KIRELEEKMHEQE---KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 434
Query: 137 ITSK-WEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISEL---------QQELKTKD 186
K W + ++ +++ E Q+ E+K + E+ Q++++ ++
Sbjct: 435 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494
Query: 187 DQYVKDLKKQSDDICLLLE------RMEEQVKNVMKTFREELYNIEKAFEV--ERQELLA 238
++ + +K D + E R EE+++ + RE+ I + E+ E++E +
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG 554
Query: 239 SNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQ--RIWDCEEYNMIKIKLEQD-V 295
++K ++ Q ++ E + + +K+ + ++++ Q +IW+ EE KI+ +++ +
Sbjct: 555 EQEEKMQE--QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEE----KIREQEEMM 608
Query: 296 QILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDE---ESTVIKSQQKRKI 341
Q E+++ +++ +EK++ + +++++E E V QQ+ K+
Sbjct: 609 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKM 657
Score = 46.6 bits (109), Expect = 8e-05
Identities = 52/282 (18%), Positives = 135/282 (47%), Gaps = 24/282 (8%)
Query: 48 EARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTEL---VTNIQVAIDIR 104
E +R+E E + +++ +E ++K ++Q+E+ R + K+ ++ I IR
Sbjct: 396 EEKRQEE--EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 453
Query: 105 EIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHC 164
E +R E+EE+ RQ E +++ ++ + + E+ K ++ +++W
Sbjct: 454 EEEKRQEQEEMWRQ-----EEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE 508
Query: 165 AGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEE---------QVKNVM 215
+ E + K+ Q+E + ++ +++ +++ + +++ EE Q + M
Sbjct: 509 EKIREQEEKMWR--QEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKM 566
Query: 216 KTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNR 275
+ E++ E+ +++++ +K WEQ + +E+ + + +K+ + E+++
Sbjct: 567 RRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEM--MQEQEEKMWEQEEKMCE 624
Query: 276 QRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLE 317
Q E+ ++ + E+ + E +L+Q++ Q +QE LE
Sbjct: 625 QEEKMQEQEEKMR-RQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 36.6 bits (83), Expect = 0.086
Identities = 29/162 (17%), Positives = 84/162 (51%), Gaps = 7/162 (4%)
Query: 227 KAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNM 286
K E E ++L++ W+ A + A L + + KK + Y ++L ++R D +
Sbjct: 154 KQLEGEARDLISRLHDSWKFAGELEQA--LSAVATQKKKADRYIEELTKER--DALSLEL 209
Query: 287 IKIKL-EQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQ--KRKINR 343
+ + +++++ +LQ++ + + + +++ N++ LK++ E + ++ QQ + + +
Sbjct: 210 YRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 269
Query: 344 LHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQK 385
L L ++ +K Q+++ + N+ +++ Q +++Q+
Sbjct: 270 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 311
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 70.1 bits (170), Expect = 7e-12
Identities = 158/752 (21%), Positives = 310/752 (41%), Gaps = 142/752 (18%)
Query: 30 DNSQERIQARRLRIAARLEARRREAL-----GEYLDGKKESEEDQSKSYK----QKEESR 80
+++++++Q ++ A+L+ E + L +K+ ED+ + ++EE
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015
Query: 81 LKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEK----LENEVKTSQDKFDE 136
LAKL ++T+++ R+ EE +RQ +EK LE + D+ E
Sbjct: 1016 KSLAKLKNKHEAMITDLE---------ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 137 ITSKWEEGKQK--RIPQELWEMLNTQQLHCAGL------LEDKNKLISELQQELKTKDDQ 188
+ ++ E K + + +EL L + A + + ISELQ++L+++
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 189 YVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQAL 248
K +KQ D+ LE ++ ++++ + + + + +R++ + KK E+
Sbjct: 1127 RNK-AEKQKRDLGEELEALKTELEDTLDSTAAQ-----QELRSKREQEVNILKKTLEEEA 1180
Query: 249 QAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQ------- 301
+ H A+ E + VE+ +QL E+ +K LE+ Q LE +
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQL--------EQTKRVKANLEKAKQTLENERGELANE 1232
Query: 302 ---LQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQ 358
L Q K + ++K+E LQ L+ + E ++++ K+ +L L+N+
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG----L 1288
Query: 359 IKQFQEENQSLTSDYKRLVMQFKELQKAMRH-----------FALIDDEK-FWEIWLMNE 406
+ Q ++ LT D+ L Q ++ Q+ ++ ++DEK + L E
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348
Query: 407 EEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPI--SQQPQKSATQIVEEMLMR 464
EEAK ++++ I T H + A ++VG + +++ ++ + +E + R
Sbjct: 1349 EEAK------HNLEKQIATLHAQV--ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR 1400
Query: 465 SEEEEAEEAAAE----------PESYLDLPKQIS-----EKTTKRILMLLCDESGFLI-- 507
EE+ A E + +DL Q EK K+ LL +E
Sbjct: 1401 HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKY 1460
Query: 508 --------------ESKLLSLLLPLE---QNECYLLRLDAIFSALG---IESEDDLYKLV 547
E+K LSL LE + + L RL+ F + S+DD+ K V
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 1520
Query: 548 NFF-------------LKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEM 594
+ +K + L LQ ++ +E +++ + E +L + E
Sbjct: 1521 HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE-VNLQAMKAQFERDLQGRDEQ 1579
Query: 595 EGEKEESLV----EGEKEEEEETPPSPWVIHPNDV----LKILEAFVMGLKKPRDS--RA 644
EK++ LV E E E E+E + LK LEA + K RD +
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639
Query: 645 PLRVQKNVRDNSKDSEYWQA-LTTVIPSSKQN 675
++Q ++D ++ + +A ++ +K+N
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKEN 1671
Score = 61.6 bits (148), Expect = 3e-09
Identities = 89/407 (21%), Positives = 165/407 (40%), Gaps = 78/407 (19%)
Query: 33 QERIQARRLRIAARLEARRR-----EALGEYLDGKKESEEDQSKSYKQK-EESRLKLAKL 86
Q ++ A +L++ +L+A E L L KK+ E+ + + EE + L
Sbjct: 875 QSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL 934
Query: 87 LLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIE------------------------- 121
++ NIQ E+ ++EEEE RQ+++
Sbjct: 935 QAEKKKMQQNIQ------ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC 988
Query: 122 KLENEVKTSQDKFDEITSKW--EEGKQKRIPQ----------ELWEMLNTQQLHCAGLLE 169
KL E K +D+ E T+ EE K K + + +L E L ++ L +
Sbjct: 989 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 170 DKNKL------ISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQV--KNV-MKTFRE 220
+ KL +S+ EL+ + + L K+ +++ L R+EE+ KN+ +K RE
Sbjct: 1049 TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108
Query: 221 ---ELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQR 277
++ +++ E ER + K+K + +ELE L ++ D R
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLG------EELEALKTELEDTLDSTAAQQELR 1162
Query: 278 IWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQ 337
+E N++K LE++ + E Q+Q+ + + E+L L+ K+
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR-----------V 1211
Query: 338 KRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQ 384
K + + L N R + A ++K + K++ Q +ELQ
Sbjct: 1212 KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ 1258
Score = 51.2 bits (121), Expect = 3e-06
Identities = 43/215 (20%), Positives = 103/215 (47%), Gaps = 18/215 (8%)
Query: 175 ISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQ 234
+S ++E+ K+++ VK +KQ L E +++ + E +++ + E +
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQ-----LAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894
Query: 235 ELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQD 294
L + ++ L A + E ++ +VE+ E++ C+ K K++Q+
Sbjct: 895 --LCAEAEELRARLTAKKQELEEICHDLEARVEEEEER--------CQHLQAEKKKMQQN 944
Query: 295 VQILEQQLQQRKAIYQ-LNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRS 353
+Q LE+QL++ ++ Q L EK+ ++ K+ EE +I Q K+ + +L + +
Sbjct: 945 IQELEEQLEEEESARQKLQLEKVTTEAKL--KKLEEEQIILEDQNCKLAKEKKLLEDRIA 1002
Query: 354 KYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMR 388
++ + + +E+++SL + +L++ +R
Sbjct: 1003 EFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLR 1037
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 70.1 bits (170), Expect = 7e-12
Identities = 121/607 (19%), Positives = 251/607 (41%), Gaps = 102/607 (16%)
Query: 42 RIAARLEARRREALGEYLDGKKESEEDQSK---SYKQKEESRLKLAKL---LLCGTELVT 95
R A LE R E L KK++ E Q K + +K E +L + +L L L+
Sbjct: 206 RDALSLELYRNTITNEEL--KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLP 263
Query: 96 NIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWE 155
+Q E+ R+ EE + ++I K E ++ +++ E +EGK + +++W
Sbjct: 264 QVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE-----QEGKMREQEEKMWR 318
Query: 156 MLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVM 215
L ++ K + E ++EL+ + K+L++Q + + E+M EQ + +
Sbjct: 319 QEKR--------LREQEKELREQEKELREQ-----KELREQEEQMQEQEEKMWEQEEKMR 365
Query: 216 ----KTFREE--LYNIEKAFEVERQELLASNKKKWEQA-----------------LQAHN 252
K +R+E L+ EK + Q++ ++ WEQ Q
Sbjct: 366 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK 425
Query: 253 AKELEYLNNRMKKVEDYEKQL-NRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQL 311
+E + + + KK D E+++ +RI + E+ K++ E++ +++ Q++
Sbjct: 426 MREEKKMQEQEKKTRDQEEKMQEEERIREREK----KMREEEETMREQEEKMQKQEENMW 481
Query: 312 NQEKLEYNLQVLKKRDEE--STVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSL 369
QE+ E+ Q L ++ E+ +Q+ KI + + + + ++ K +++E
Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 541
Query: 370 TSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLG 429
D Q E ++ MR ++K W+ E++ ++ + +D + +
Sbjct: 542 QED------QMWEQEEKMRD----QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE--- 588
Query: 430 LPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEE---EAEEAAAEPESYL-DLPK 485
+ ++ EE +MR +EE E EE E E + + +
Sbjct: 589 -----------------ERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Query: 486 QISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYK 545
++ E+ K M +E + E K+ EQ E L + + ++ +++
Sbjct: 632 KMQEQEEK---MWEQEEKMWEQEEKMWEQQRLPEQKE-KLWEHEKMQEQEKMQEQEEKI- 686
Query: 546 LVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESLVEG 605
+ ++ Q + EK EE+ E ++ E+ EM E+EE + E
Sbjct: 687 -------WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ 739
Query: 606 EKEEEEE 612
E++ +E+
Sbjct: 740 EEKMQEQ 746
Score = 65.1 bits (157), Expect = 2e-10
Identities = 76/389 (19%), Positives = 171/389 (43%), Gaps = 49/389 (12%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
+ERI+ R ++ E R + E + ++E+ +Q + K+ ++ RL K L E
Sbjct: 449 EERIREREKKMREEEETMREQE--EKMQKQEENMWEQEE--KEWQQQRLPEQKEKLWEQE 504
Query: 93 LVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQE 152
+ + I +E R +EE +++ + +++ +D+ E K + +QK QE
Sbjct: 505 KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE 564
Query: 153 LWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVK 212
TQ+ +++ E +E + K + + +++Q + + E+M+EQ
Sbjct: 565 ERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQ-- 622
Query: 213 NVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQ 272
E+++ E+ + + +++ +K WEQ K E
Sbjct: 623 ------EEKMWEQEEKMQEQEEKMWEQEEKMWEQ---------------EEKMWEQQRLP 661
Query: 273 LNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTV 332
++++W+ E+ + EQ+ +I EQ+ ++K QEK ++ + K R+EES
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKT---QEQEKKTWDQE--KMREEES-- 714
Query: 333 IKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKEL--------- 383
++++K+ +++ K +Q ++ QE+ + + +++ Q +++
Sbjct: 715 -MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQ 773
Query: 384 -QKAMRHFALIDDEKFWEIWLMNEEEAKD 411
+K H + + EK WE EE+ +D
Sbjct: 774 KEKLWEHEKMQEQEKIWE----QEEKMRD 798
Score = 58.5 bits (140), Expect = 2e-08
Identities = 61/338 (18%), Positives = 164/338 (48%), Gaps = 37/338 (10%)
Query: 62 KKESEEDQSKSY----KQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKR 117
+K+++E + K++ K +EE R++ + + E + +RE +++E+E K
Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM--------MREQEEKMQEQEEKM 619
Query: 118 QRIEKL----ENEVKTSQDKFDEITSK-WEEGK----QKRIPQE---LWEMLNTQQLHCA 165
Q E+ E +++ ++K E K WE+ + Q+R+P++ LWE Q+
Sbjct: 620 QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE-- 677
Query: 166 GLLEDKNKLISELQQELKTKDDQ---YVKDLKKQSDDICLLLERMEEQVKNVMKTFREEL 222
+ E + K+ + + E KT++ + + ++ ++ + + ++M E+ + +M+ E++
Sbjct: 678 KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREE-EEMMREQEEKM 736
Query: 223 YNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCE 282
E+ + + +E+ +K WE Q E + L + +K+ ++EK +++IW+ E
Sbjct: 737 QEQEEKMQEQEEEMWEQEEKMWE---QEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE 793
Query: 283 EYNMIKIK----LEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQK 338
E + + E+ ++ E++++ ++ +EK+ + + ++E+ + + +
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKME 853
Query: 339 RKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRL 376
K+ + + K Q ++ +E+ + + +++
Sbjct: 854 EKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 69.3 bits (168), Expect = 1e-11
Identities = 72/343 (20%), Positives = 159/343 (46%), Gaps = 50/343 (14%)
Query: 37 QARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTN 96
+A +R+ + + E + ++ + E EED+ + Q + R K+A+ +L
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ---QLQAERKKMAQQML-------- 953
Query: 97 IQVAIDIREIHRRVEEEEIKRQR-----------IEKLENEVKTSQDKFDEITSKWEEGK 145
++ ++EEEE RQ+ I+KLE+E+ D+ +++ SK +
Sbjct: 954 --------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-SKERKLL 1004
Query: 146 QKRIPQELWEMLNTQQLHCAGLLEDKNK---LISELQQELKTKDDQYVKDLKKQSDDICL 202
++RI +L L ++ L + KNK +ISEL+ LK K+ K + +
Sbjct: 1005 EERI-SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK-------KEEKSRQE---- 1052
Query: 203 LLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNR 262
LE+++ +++ F E++ +++ ++ ++ + K++ QA A E+ NN
Sbjct: 1053 -LEKLKRKLEGDASDFHEQIADLQA--QIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 263 MKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQV 322
+KK+ + E ++ + D + + K E+ + L ++L+ K + + ++
Sbjct: 1110 LKKIRELEGHISDLQE-DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 323 LKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
KR++E TV+K + + +R K+A+ +++ E+
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Score = 59.7 bits (143), Expect = 1e-08
Identities = 137/628 (21%), Positives = 255/628 (40%), Gaps = 93/628 (14%)
Query: 41 LRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVA 100
L + + E + R+ L + K++ E D S ++Q + + ++A+L + + +Q A
Sbjct: 1039 LEVRLKKEEKSRQELEKL---KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 101 IDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFD-EITSKWEEGKQKRIPQELWEMLNT 159
+ + + ++ ++I +LE + Q+ D E ++ + KQKR E E L T
Sbjct: 1096 L--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1153
Query: 160 QQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFR 219
+ LED + QQEL+ K +Q V LKK D+ E ++++
Sbjct: 1154 E-------LEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 220 EELYNIEKAFEVERQELLASNKKKWEQALQAHNAK---ELEYLNNRMKKVEDYEKQLNRQ 276
EEL ++E+ + +N K +Q L+ NA EL L ++VE +K+L Q
Sbjct: 1206 EELTE-----QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 277 ------RIWDCEE------------YNMIK-------------IKLEQDVQILEQQLQ-- 303
+ D E N ++ IKL +DV L QLQ
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 304 ----QRKAIYQLN----QEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSK- 354
Q + +LN +LE L+ + +E K +R I+ L+ L++ + K
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 355 --YAKQI-------KQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMN 405
+A + K+FQ+E ++LT Y+ + +L+K D+ + L N
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV--VDLDN 1438
Query: 406 EEE-AKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMR 464
+ + +L + D+++ A + + S + +EE L
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 465 SEEEEAEEAAAEPE------SYLDLPKQISE-KTTKRILMLLCDESGFLIESKLLSLLLP 517
EE E + E S D+ K + E + +KR L +E ++++L L
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE----MKTQLEELEDE 1554
Query: 518 LEQNECYLLRLDAIFSAL------GIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQAS 571
L+ E LRL+ AL +++ D+ + L+ + H + L+ + +A
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 572 MEKASMEETSTRSELELAEQTEMEGEKE 599
A + +LEL + ++G +E
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREE 1642
Score = 59.3 bits (142), Expect = 1e-08
Identities = 71/317 (22%), Positives = 141/317 (44%), Gaps = 36/317 (11%)
Query: 91 TELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEIT-SKWEEGKQKRI 149
T++ +QV E+ + +E + ++R +K ENE+K + K ++T K +Q +
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 150 PQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDD---QYVKDLKKQSDDICLLLER 206
EL+ ++ A ++ +++ E++ L+ ++D Q + KK + + L E+
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 207 MEEQVKNVMKTFREELYNIEKAFEVERQEL--------LASNKKKWEQ---------ALQ 249
+EE+ K E++ K ++E + L L+ +K E+ A +
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 250 AHNAKELEYLNNRMKK-VEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQ---LQQR 305
AK L L N+ + + + E +L ++ +E +K KLE D +Q LQ +
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEE-KSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 306 KAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNL----------RSKY 355
A ++ K E LQ R ++ K+ +KI L +++L R+K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 356 AKQIKQFQEENQSLTSD 372
KQ + EE ++L ++
Sbjct: 1138 EKQKRDLGEELEALKTE 1154
Score = 58.5 bits (140), Expect = 2e-08
Identities = 132/624 (21%), Positives = 255/624 (40%), Gaps = 98/624 (15%)
Query: 13 NVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKS 72
N++ H+ST ++ +S++++Q + A E ++R + ++ + E+++ +
Sbjct: 1361 NLERHISTL----NIQLSDSKKKLQDFASTVEALEEGKKR--FQKEIENLTQQYEEKAAA 1414
Query: 73 YKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQD 132
Y + E+++ +L + L + +D+ + V E K+++ ++L E K
Sbjct: 1415 YDKLEKTKNRLQQEL---------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 133 KF-DEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLI-SELQQELKTKDD--Q 188
K+ DE E ++K + L LE NK++ +E++ + +KDD +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525
Query: 189 YVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKA---FEVERQELLASNKKKWE 245
V +L+K LE E++K ++ +EL E A EV Q L K ++E
Sbjct: 1526 NVHELEKSKR----ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL----KGQFE 1577
Query: 246 QALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQR 305
+ LQA + + E +++ +YE +L +R K KLE D++ LE LQ
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA-AAAKKKLEGDLKDLE--LQAD 1634
Query: 306 KAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
AI + E ++ L+K +++Q K L D + R + K+ +++
Sbjct: 1635 SAI-----KGREEAIKQLRK-------LQAQMKDFQRELEDARAS-RDEIFATAKENEKK 1681
Query: 366 NQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWL------MNEEEAKDLIARAFDV 419
+SL +D +L ++A + L +E E+ ++E + L AR +
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 420 DRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPES 479
+ + N+ +S + +K ATQ E++ S E E + A+
Sbjct: 1742 EEELEEEQ-------------GNMEAMSDRVRK-ATQQAEQL---SNELATERSTAQKN- 1783
Query: 480 YLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIES 539
+ +Q E+ K + L + G ++SK S + LE L +E
Sbjct: 1784 --ESARQQLERQNKELRSKLHEMEG-AVKSKFKSTIAALEAKIAQLEE--------QVEQ 1832
Query: 540 EDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKE 599
E + LK + +L L E ++AEQ + + EK
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEIL-----------------LQVEDERKMAEQYKEQAEKG 1875
Query: 600 ESLVEGEKEEEEETPPSPWVIHPN 623
+ V+ K + EE I+ N
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINAN 1899
Score = 37.4 bits (85), Expect = 0.051
Identities = 102/524 (19%), Positives = 200/524 (38%), Gaps = 85/524 (16%)
Query: 245 EQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQI------- 297
E+ +QA EL+ R +K E+ K+L ++ EE N+++ +L+ + ++
Sbjct: 851 EEEMQAKE-DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 298 ----------LEQQLQQRKAI--------YQLNQEKLEYNLQVL----KKRDEESTVIKS 335
LE+ L + +A QL E+ + Q+L + +EE+ K
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 336 QQKR-----KINRLHD---ILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAM 387
Q ++ KI +L D ++++ +K +K+ K +E LT++ + K L K
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 388 -RHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPI 446
+H ++I + E+ L EE+++ + + L A DF
Sbjct: 1030 NKHESMISE---LEVRLKKEEKSRQELEKL----------KRKLEGDASDF--------- 1067
Query: 447 SQQPQKSATQIVE-EMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGF 505
+Q QI E +M + +EEE + A A L +I++K L + + G
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALAR------LDDEIAQK--NNALKKIRELEGH 1119
Query: 506 L--IESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQ 563
+ ++ L S + E L AL E ED L L+
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT----------QQELR 1169
Query: 564 IKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESL---VEGEKEEEEETPPSPWVI 620
K + ++ K +++E + E ++ E + + E L +E K + + +
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 621 HPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDAL 680
+ E V+G K +++ V++ + + L + +
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 681 YTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLNSKIN 724
+ + + KL + +SL Q + Q LLQ+ K+N
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Score = 35.0 bits (79), Expect = 0.25
Identities = 79/403 (19%), Positives = 164/403 (40%), Gaps = 66/403 (16%)
Query: 339 RKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKF 398
R ++ +L R + Q K+ +E Q ++ + KEL++ +H L +++
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQ--KHSQLTEEKNL 891
Query: 399 W--------EIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQP 450
E++ EE L A+ +++ I+H L QQ
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL----------EEEEDRGQQL 941
Query: 451 QKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRI---LMLLCDESGFLI 507
Q ++ ++ML E+ E EEAA + L L K +E K++ ++++ D++ L
Sbjct: 942 QAERKKMAQQMLDLEEQLEEEEAARQK---LQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 508 ESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPC 567
+ + L LE+ R+ + + L E E+ L LK + + S L+++
Sbjct: 999 KERKL-----LEE------RISDLTTNLA-EEEEKAKNLTK--LKNKHESMISELEVR-L 1043
Query: 568 SQASMEKASMEETSTRSELELAEQTEMEGEKEESLVE-----GEKEEEEETPPS---PWV 619
+ + +E+ + E + ++ E + + + E +KEEE + + +
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 620 IHPNDVLK---ILEAFVMGLKKPRDSRAPLR--VQKNVRDNSKDSEYWQALTTVIPSSKQ 674
N+ LK LE + L++ DS R +K RD ++ E + K
Sbjct: 1104 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE----------ALKT 1153
Query: 675 NLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQ 717
L D L + + L + ++ + +L+++ +A +Q+
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 69.3 bits (168), Expect = 1e-11
Identities = 72/343 (20%), Positives = 159/343 (46%), Gaps = 50/343 (14%)
Query: 37 QARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTN 96
+A +R+ + + E + ++ + E EED+ + Q + R K+A+ +L
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ---QLQAERKKMAQQML-------- 960
Query: 97 IQVAIDIREIHRRVEEEEIKRQR-----------IEKLENEVKTSQDKFDEITSKWEEGK 145
++ ++EEEE RQ+ I+KLE+E+ D+ +++ SK +
Sbjct: 961 --------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-SKERKLL 1011
Query: 146 QKRIPQELWEMLNTQQLHCAGLLEDKNK---LISELQQELKTKDDQYVKDLKKQSDDICL 202
++RI +L L ++ L + KNK +ISEL+ LK K+ K + +
Sbjct: 1012 EERI-SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK-------KEEKSRQE---- 1059
Query: 203 LLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNR 262
LE+++ +++ F E++ +++ ++ ++ + K++ QA A E+ NN
Sbjct: 1060 -LEKLKRKLEGDASDFHEQIADLQA--QIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 263 MKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQV 322
+KK+ + E ++ + D + + K E+ + L ++L+ K + + ++
Sbjct: 1117 LKKIRELEGHISDLQE-DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 323 LKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
KR++E TV+K + + +R K+A+ +++ E+
Sbjct: 1176 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Score = 59.7 bits (143), Expect = 1e-08
Identities = 137/628 (21%), Positives = 255/628 (40%), Gaps = 93/628 (14%)
Query: 41 LRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVA 100
L + + E + R+ L + K++ E D S ++Q + + ++A+L + + +Q A
Sbjct: 1046 LEVRLKKEEKSRQELEKL---KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 101 IDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFD-EITSKWEEGKQKRIPQELWEMLNT 159
+ + + ++ ++I +LE + Q+ D E ++ + KQKR E E L T
Sbjct: 1103 L--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1160
Query: 160 QQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFR 219
+ LED + QQEL+ K +Q V LKK D+ E ++++
Sbjct: 1161 E-------LEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 220 EELYNIEKAFEVERQELLASNKKKWEQALQAHNAK---ELEYLNNRMKKVEDYEKQLNRQ 276
EEL ++E+ + +N K +Q L+ NA EL L ++VE +K+L Q
Sbjct: 1213 EELTE-----QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 277 ------RIWDCEE------------YNMIK-------------IKLEQDVQILEQQLQ-- 303
+ D E N ++ IKL +DV L QLQ
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 304 ----QRKAIYQLN----QEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSK- 354
Q + +LN +LE L+ + +E K +R I+ L+ L++ + K
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 355 --YAKQI-------KQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMN 405
+A + K+FQ+E ++LT Y+ + +L+K D+ + L N
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV--VDLDN 1445
Query: 406 EEE-AKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMR 464
+ + +L + D+++ A + + S + +EE L
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 465 SEEEEAEEAAAEPE------SYLDLPKQISE-KTTKRILMLLCDESGFLIESKLLSLLLP 517
EE E + E S D+ K + E + +KR L +E ++++L L
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE----MKTQLEELEDE 1561
Query: 518 LEQNECYLLRLDAIFSAL------GIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQAS 571
L+ E LRL+ AL +++ D+ + L+ + H + L+ + +A
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 572 MEKASMEETSTRSELELAEQTEMEGEKE 599
A + +LEL + ++G +E
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREE 1649
Score = 59.3 bits (142), Expect = 1e-08
Identities = 71/317 (22%), Positives = 141/317 (44%), Gaps = 36/317 (11%)
Query: 91 TELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEIT-SKWEEGKQKRI 149
T++ +QV E+ + +E + ++R +K ENE+K + K ++T K +Q +
Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 150 PQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDD---QYVKDLKKQSDDICLLLER 206
EL+ ++ A ++ +++ E++ L+ ++D Q + KK + + L E+
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 207 MEEQVKNVMKTFREELYNIEKAFEVERQEL--------LASNKKKWEQ---------ALQ 249
+EE+ K E++ K ++E + L L+ +K E+ A +
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 250 AHNAKELEYLNNRMKK-VEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQ---LQQR 305
AK L L N+ + + + E +L ++ +E +K KLE D +Q LQ +
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEE-KSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 306 KAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNL----------RSKY 355
A ++ K E LQ R ++ K+ +KI L +++L R+K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 356 AKQIKQFQEENQSLTSD 372
KQ + EE ++L ++
Sbjct: 1145 EKQKRDLGEELEALKTE 1161
Score = 58.5 bits (140), Expect = 2e-08
Identities = 132/624 (21%), Positives = 255/624 (40%), Gaps = 98/624 (15%)
Query: 13 NVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKS 72
N++ H+ST ++ +S++++Q + A E ++R + ++ + E+++ +
Sbjct: 1368 NLERHISTL----NIQLSDSKKKLQDFASTVEALEEGKKR--FQKEIENLTQQYEEKAAA 1421
Query: 73 YKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQD 132
Y + E+++ +L + L + +D+ + V E K+++ ++L E K
Sbjct: 1422 YDKLEKTKNRLQQEL---------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 133 KF-DEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLI-SELQQELKTKDD--Q 188
K+ DE E ++K + L LE NK++ +E++ + +KDD +
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1532
Query: 189 YVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKA---FEVERQELLASNKKKWE 245
V +L+K LE E++K ++ +EL E A EV Q L K ++E
Sbjct: 1533 NVHELEKSKR----ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL----KGQFE 1584
Query: 246 QALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQR 305
+ LQA + + E +++ +YE +L +R K KLE D++ LE LQ
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA-AAAKKKLEGDLKDLE--LQAD 1641
Query: 306 KAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
AI + E ++ L+K +++Q K L D + R + K+ +++
Sbjct: 1642 SAI-----KGREEAIKQLRK-------LQAQMKDFQRELEDARAS-RDEIFATAKENEKK 1688
Query: 366 NQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWL------MNEEEAKDLIARAFDV 419
+SL +D +L ++A + L +E E+ ++E + L AR +
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 420 DRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPES 479
+ + N+ +S + +K ATQ E++ S E E + A+
Sbjct: 1749 EEELEEEQ-------------GNMEAMSDRVRK-ATQQAEQL---SNELATERSTAQKN- 1790
Query: 480 YLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIES 539
+ +Q E+ K + L + G ++SK S + LE L +E
Sbjct: 1791 --ESARQQLERQNKELRSKLHEMEG-AVKSKFKSTIAALEAKIAQLEE--------QVEQ 1839
Query: 540 EDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKE 599
E + LK + +L L E ++AEQ + + EK
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEIL-----------------LQVEDERKMAEQYKEQAEKG 1882
Query: 600 ESLVEGEKEEEEETPPSPWVIHPN 623
+ V+ K + EE I+ N
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINAN 1906
Score = 37.4 bits (85), Expect = 0.051
Identities = 102/524 (19%), Positives = 200/524 (38%), Gaps = 85/524 (16%)
Query: 245 EQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQI------- 297
E+ +QA EL+ R +K E+ K+L ++ EE N+++ +L+ + ++
Sbjct: 858 EEEMQAKE-DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 298 ----------LEQQLQQRKAI--------YQLNQEKLEYNLQVL----KKRDEESTVIKS 335
LE+ L + +A QL E+ + Q+L + +EE+ K
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 336 QQKR-----KINRLHD---ILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAM 387
Q ++ KI +L D ++++ +K +K+ K +E LT++ + K L K
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 388 -RHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPI 446
+H ++I + E+ L EE+++ + + L A DF
Sbjct: 1037 NKHESMISE---LEVRLKKEEKSRQELEKL----------KRKLEGDASDF--------- 1074
Query: 447 SQQPQKSATQIVE-EMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGF 505
+Q QI E +M + +EEE + A A L +I++K L + + G
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALAR------LDDEIAQK--NNALKKIRELEGH 1126
Query: 506 L--IESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQ 563
+ ++ L S + E L AL E ED L L+
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT----------QQELR 1176
Query: 564 IKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESL---VEGEKEEEEETPPSPWVI 620
K + ++ K +++E + E ++ E + + E L +E K + + +
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 621 HPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDAL 680
+ E V+G K +++ V++ + + L + +
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 681 YTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLNSKIN 724
+ + + KL + +SL Q + Q LLQ+ K+N
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Score = 35.0 bits (79), Expect = 0.25
Identities = 79/403 (19%), Positives = 164/403 (40%), Gaps = 66/403 (16%)
Query: 339 RKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKF 398
R ++ +L R + Q K+ +E Q ++ + KEL++ +H L +++
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQ--KHSQLTEEKNL 898
Query: 399 W--------EIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQP 450
E++ EE L A+ +++ I+H L QQ
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL----------EEEEDRGQQL 948
Query: 451 QKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRI---LMLLCDESGFLI 507
Q ++ ++ML E+ E EEAA + L L K +E K++ ++++ D++ L
Sbjct: 949 QAERKKMAQQMLDLEEQLEEEEAARQK---LQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 508 ESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPC 567
+ + L LE+ R+ + + L E E+ L LK + + S L+++
Sbjct: 1006 KERKL-----LEE------RISDLTTNLA-EEEEKAKNLTK--LKNKHESMISELEVR-L 1050
Query: 568 SQASMEKASMEETSTRSELELAEQTEMEGEKEESLVE-----GEKEEEEETPPS---PWV 619
+ + +E+ + E + ++ E + + + E +KEEE + + +
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 620 IHPNDVLK---ILEAFVMGLKKPRDSRAPLR--VQKNVRDNSKDSEYWQALTTVIPSSKQ 674
N+ LK LE + L++ DS R +K RD ++ E + K
Sbjct: 1111 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE----------ALKT 1160
Query: 675 NLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQ 717
L D L + + L + ++ + +L+++ +A +Q+
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 69.3 bits (168), Expect = 1e-11
Identities = 72/343 (20%), Positives = 159/343 (46%), Gaps = 50/343 (14%)
Query: 37 QARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTN 96
+A +R+ + + E + ++ + E EED+ + Q + R K+A+ +L
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ---QLQAERKKMAQQML-------- 960
Query: 97 IQVAIDIREIHRRVEEEEIKRQR-----------IEKLENEVKTSQDKFDEITSKWEEGK 145
++ ++EEEE RQ+ I+KLE+E+ D+ +++ SK +
Sbjct: 961 --------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-SKERKLL 1011
Query: 146 QKRIPQELWEMLNTQQLHCAGLLEDKNK---LISELQQELKTKDDQYVKDLKKQSDDICL 202
++RI +L L ++ L + KNK +ISEL+ LK K+ K + +
Sbjct: 1012 EERI-SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK-------KEEKSRQE---- 1059
Query: 203 LLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNR 262
LE+++ +++ F E++ +++ ++ ++ + K++ QA A E+ NN
Sbjct: 1060 -LEKLKRKLEGDASDFHEQIADLQA--QIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 263 MKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQV 322
+KK+ + E ++ + D + + K E+ + L ++L+ K + + ++
Sbjct: 1117 LKKIRELEGHISDLQE-DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 323 LKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
KR++E TV+K + + +R K+A+ +++ E+
Sbjct: 1176 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Score = 59.7 bits (143), Expect = 1e-08
Identities = 137/628 (21%), Positives = 255/628 (40%), Gaps = 93/628 (14%)
Query: 41 LRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVA 100
L + + E + R+ L + K++ E D S ++Q + + ++A+L + + +Q A
Sbjct: 1046 LEVRLKKEEKSRQELEKL---KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 101 IDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFD-EITSKWEEGKQKRIPQELWEMLNT 159
+ + + ++ ++I +LE + Q+ D E ++ + KQKR E E L T
Sbjct: 1103 L--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1160
Query: 160 QQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFR 219
+ LED + QQEL+ K +Q V LKK D+ E ++++
Sbjct: 1161 E-------LEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 220 EELYNIEKAFEVERQELLASNKKKWEQALQAHNAK---ELEYLNNRMKKVEDYEKQLNRQ 276
EEL ++E+ + +N K +Q L+ NA EL L ++VE +K+L Q
Sbjct: 1213 EELTE-----QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 277 ------RIWDCEE------------YNMIK-------------IKLEQDVQILEQQLQ-- 303
+ D E N ++ IKL +DV L QLQ
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 304 ----QRKAIYQLN----QEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSK- 354
Q + +LN +LE L+ + +E K +R I+ L+ L++ + K
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 355 --YAKQI-------KQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMN 405
+A + K+FQ+E ++LT Y+ + +L+K D+ + L N
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV--VDLDN 1445
Query: 406 EEE-AKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMR 464
+ + +L + D+++ A + + S + +EE L
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 465 SEEEEAEEAAAEPE------SYLDLPKQISE-KTTKRILMLLCDESGFLIESKLLSLLLP 517
EE E + E S D+ K + E + +KR L +E ++++L L
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE----MKTQLEELEDE 1561
Query: 518 LEQNECYLLRLDAIFSAL------GIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQAS 571
L+ E LRL+ AL +++ D+ + L+ + H + L+ + +A
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 572 MEKASMEETSTRSELELAEQTEMEGEKE 599
A + +LEL + ++G +E
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREE 1649
Score = 59.3 bits (142), Expect = 1e-08
Identities = 71/317 (22%), Positives = 141/317 (44%), Gaps = 36/317 (11%)
Query: 91 TELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEIT-SKWEEGKQKRI 149
T++ +QV E+ + +E + ++R +K ENE+K + K ++T K +Q +
Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 150 PQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDD---QYVKDLKKQSDDICLLLER 206
EL+ ++ A ++ +++ E++ L+ ++D Q + KK + + L E+
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 207 MEEQVKNVMKTFREELYNIEKAFEVERQEL--------LASNKKKWEQ---------ALQ 249
+EE+ K E++ K ++E + L L+ +K E+ A +
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 250 AHNAKELEYLNNRMKK-VEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQ---LQQR 305
AK L L N+ + + + E +L ++ +E +K KLE D +Q LQ +
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEE-KSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 306 KAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNL----------RSKY 355
A ++ K E LQ R ++ K+ +KI L +++L R+K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 356 AKQIKQFQEENQSLTSD 372
KQ + EE ++L ++
Sbjct: 1145 EKQKRDLGEELEALKTE 1161
Score = 58.5 bits (140), Expect = 2e-08
Identities = 132/624 (21%), Positives = 255/624 (40%), Gaps = 98/624 (15%)
Query: 13 NVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKS 72
N++ H+ST ++ +S++++Q + A E ++R + ++ + E+++ +
Sbjct: 1368 NLERHISTL----NIQLSDSKKKLQDFASTVEALEEGKKR--FQKEIENLTQQYEEKAAA 1421
Query: 73 YKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQD 132
Y + E+++ +L + L + +D+ + V E K+++ ++L E K
Sbjct: 1422 YDKLEKTKNRLQQEL---------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 133 KF-DEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLI-SELQQELKTKDD--Q 188
K+ DE E ++K + L LE NK++ +E++ + +KDD +
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1532
Query: 189 YVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKA---FEVERQELLASNKKKWE 245
V +L+K LE E++K ++ +EL E A EV Q L K ++E
Sbjct: 1533 NVHELEKSKR----ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL----KGQFE 1584
Query: 246 QALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQR 305
+ LQA + + E +++ +YE +L +R K KLE D++ LE LQ
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA-AAAKKKLEGDLKDLE--LQAD 1641
Query: 306 KAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
AI + E ++ L+K +++Q K L D + R + K+ +++
Sbjct: 1642 SAI-----KGREEAIKQLRK-------LQAQMKDFQRELEDARAS-RDEIFATAKENEKK 1688
Query: 366 NQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWL------MNEEEAKDLIARAFDV 419
+SL +D +L ++A + L +E E+ ++E + L AR +
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 420 DRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPES 479
+ + N+ +S + +K ATQ E++ S E E + A+
Sbjct: 1749 EEELEEEQ-------------GNMEAMSDRVRK-ATQQAEQL---SNELATERSTAQKN- 1790
Query: 480 YLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIES 539
+ +Q E+ K + L + G ++SK S + LE L +E
Sbjct: 1791 --ESARQQLERQNKELRSKLHEMEG-AVKSKFKSTIAALEAKIAQLEE--------QVEQ 1839
Query: 540 EDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKE 599
E + LK + +L L E ++AEQ + + EK
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEIL-----------------LQVEDERKMAEQYKEQAEKG 1882
Query: 600 ESLVEGEKEEEEETPPSPWVIHPN 623
+ V+ K + EE I+ N
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINAN 1906
Score = 37.4 bits (85), Expect = 0.051
Identities = 102/524 (19%), Positives = 200/524 (38%), Gaps = 85/524 (16%)
Query: 245 EQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQI------- 297
E+ +QA EL+ R +K E+ K+L ++ EE N+++ +L+ + ++
Sbjct: 858 EEEMQAKE-DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 298 ----------LEQQLQQRKAI--------YQLNQEKLEYNLQVL----KKRDEESTVIKS 335
LE+ L + +A QL E+ + Q+L + +EE+ K
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 336 QQKR-----KINRLHD---ILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAM 387
Q ++ KI +L D ++++ +K +K+ K +E LT++ + K L K
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 388 -RHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPI 446
+H ++I + E+ L EE+++ + + L A DF
Sbjct: 1037 NKHESMISE---LEVRLKKEEKSRQELEKL----------KRKLEGDASDF--------- 1074
Query: 447 SQQPQKSATQIVE-EMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGF 505
+Q QI E +M + +EEE + A A L +I++K L + + G
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALAR------LDDEIAQK--NNALKKIRELEGH 1126
Query: 506 L--IESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQ 563
+ ++ L S + E L AL E ED L L+
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT----------QQELR 1176
Query: 564 IKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESL---VEGEKEEEEETPPSPWVI 620
K + ++ K +++E + E ++ E + + E L +E K + + +
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 621 HPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDAL 680
+ E V+G K +++ V++ + + L + +
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 681 YTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLNSKIN 724
+ + + KL + +SL Q + Q LLQ+ K+N
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Score = 35.0 bits (79), Expect = 0.25
Identities = 79/403 (19%), Positives = 164/403 (40%), Gaps = 66/403 (16%)
Query: 339 RKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKF 398
R ++ +L R + Q K+ +E Q ++ + KEL++ +H L +++
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQ--KHSQLTEEKNL 898
Query: 399 W--------EIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQP 450
E++ EE L A+ +++ I+H L QQ
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL----------EEEEDRGQQL 948
Query: 451 QKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRI---LMLLCDESGFLI 507
Q ++ ++ML E+ E EEAA + L L K +E K++ ++++ D++ L
Sbjct: 949 QAERKKMAQQMLDLEEQLEEEEAARQK---LQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 508 ESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPC 567
+ + L LE+ R+ + + L E E+ L LK + + S L+++
Sbjct: 1006 KERKL-----LEE------RISDLTTNLA-EEEEKAKNLTK--LKNKHESMISELEVR-L 1050
Query: 568 SQASMEKASMEETSTRSELELAEQTEMEGEKEESLVE-----GEKEEEEETPPS---PWV 619
+ + +E+ + E + ++ E + + + E +KEEE + + +
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 620 IHPNDVLK---ILEAFVMGLKKPRDSRAPLR--VQKNVRDNSKDSEYWQALTTVIPSSKQ 674
N+ LK LE + L++ DS R +K RD ++ E + K
Sbjct: 1111 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE----------ALKT 1160
Query: 675 NLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQ 717
L D L + + L + ++ + +L+++ +A +Q+
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 69.3 bits (168), Expect = 1e-11
Identities = 72/343 (20%), Positives = 159/343 (46%), Gaps = 50/343 (14%)
Query: 37 QARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTN 96
+A +R+ + + E + ++ + E EED+ + Q + R K+A+ +L
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ---QLQAERKKMAQQML-------- 953
Query: 97 IQVAIDIREIHRRVEEEEIKRQR-----------IEKLENEVKTSQDKFDEITSKWEEGK 145
++ ++EEEE RQ+ I+KLE+E+ D+ +++ SK +
Sbjct: 954 --------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-SKERKLL 1004
Query: 146 QKRIPQELWEMLNTQQLHCAGLLEDKNK---LISELQQELKTKDDQYVKDLKKQSDDICL 202
++RI +L L ++ L + KNK +ISEL+ LK K+ K + +
Sbjct: 1005 EERI-SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK-------KEEKSRQE---- 1052
Query: 203 LLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNR 262
LE+++ +++ F E++ +++ ++ ++ + K++ QA A E+ NN
Sbjct: 1053 -LEKLKRKLEGDASDFHEQIADLQA--QIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 263 MKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQV 322
+KK+ + E ++ + D + + K E+ + L ++L+ K + + ++
Sbjct: 1110 LKKIRELEGHISDLQE-DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 323 LKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
KR++E TV+K + + +R K+A+ +++ E+
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Score = 59.7 bits (143), Expect = 1e-08
Identities = 137/628 (21%), Positives = 255/628 (40%), Gaps = 93/628 (14%)
Query: 41 LRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVA 100
L + + E + R+ L + K++ E D S ++Q + + ++A+L + + +Q A
Sbjct: 1039 LEVRLKKEEKSRQELEKL---KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 101 IDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFD-EITSKWEEGKQKRIPQELWEMLNT 159
+ + + ++ ++I +LE + Q+ D E ++ + KQKR E E L T
Sbjct: 1096 L--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1153
Query: 160 QQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFR 219
+ LED + QQEL+ K +Q V LKK D+ E ++++
Sbjct: 1154 E-------LEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 220 EELYNIEKAFEVERQELLASNKKKWEQALQAHNAK---ELEYLNNRMKKVEDYEKQLNRQ 276
EEL ++E+ + +N K +Q L+ NA EL L ++VE +K+L Q
Sbjct: 1206 EELTE-----QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 277 ------RIWDCEE------------YNMIK-------------IKLEQDVQILEQQLQ-- 303
+ D E N ++ IKL +DV L QLQ
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 304 ----QRKAIYQLN----QEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSK- 354
Q + +LN +LE L+ + +E K +R I+ L+ L++ + K
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 355 --YAKQI-------KQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMN 405
+A + K+FQ+E ++LT Y+ + +L+K D+ + L N
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV--VDLDN 1438
Query: 406 EEE-AKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMR 464
+ + +L + D+++ A + + S + +EE L
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 465 SEEEEAEEAAAEPE------SYLDLPKQISE-KTTKRILMLLCDESGFLIESKLLSLLLP 517
EE E + E S D+ K + E + +KR L +E ++++L L
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE----MKTQLEELEDE 1554
Query: 518 LEQNECYLLRLDAIFSAL------GIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQAS 571
L+ E LRL+ AL +++ D+ + L+ + H + L+ + +A
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 572 MEKASMEETSTRSELELAEQTEMEGEKE 599
A + +LEL + ++G +E
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREE 1642
Score = 59.3 bits (142), Expect = 1e-08
Identities = 71/317 (22%), Positives = 141/317 (44%), Gaps = 36/317 (11%)
Query: 91 TELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEIT-SKWEEGKQKRI 149
T++ +QV E+ + +E + ++R +K ENE+K + K ++T K +Q +
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 150 PQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDD---QYVKDLKKQSDDICLLLER 206
EL+ ++ A ++ +++ E++ L+ ++D Q + KK + + L E+
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 207 MEEQVKNVMKTFREELYNIEKAFEVERQEL--------LASNKKKWEQ---------ALQ 249
+EE+ K E++ K ++E + L L+ +K E+ A +
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 250 AHNAKELEYLNNRMKK-VEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQ---LQQR 305
AK L L N+ + + + E +L ++ +E +K KLE D +Q LQ +
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEE-KSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 306 KAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNL----------RSKY 355
A ++ K E LQ R ++ K+ +KI L +++L R+K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 356 AKQIKQFQEENQSLTSD 372
KQ + EE ++L ++
Sbjct: 1138 EKQKRDLGEELEALKTE 1154
Score = 58.5 bits (140), Expect = 2e-08
Identities = 132/624 (21%), Positives = 255/624 (40%), Gaps = 98/624 (15%)
Query: 13 NVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKS 72
N++ H+ST ++ +S++++Q + A E ++R + ++ + E+++ +
Sbjct: 1361 NLERHISTL----NIQLSDSKKKLQDFASTVEALEEGKKR--FQKEIENLTQQYEEKAAA 1414
Query: 73 YKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQD 132
Y + E+++ +L + L + +D+ + V E K+++ ++L E K
Sbjct: 1415 YDKLEKTKNRLQQEL---------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 133 KF-DEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLI-SELQQELKTKDD--Q 188
K+ DE E ++K + L LE NK++ +E++ + +KDD +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525
Query: 189 YVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKA---FEVERQELLASNKKKWE 245
V +L+K LE E++K ++ +EL E A EV Q L K ++E
Sbjct: 1526 NVHELEKSKR----ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL----KGQFE 1577
Query: 246 QALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQR 305
+ LQA + + E +++ +YE +L +R K KLE D++ LE LQ
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA-AAAKKKLEGDLKDLE--LQAD 1634
Query: 306 KAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
AI + E ++ L+K +++Q K L D + R + K+ +++
Sbjct: 1635 SAI-----KGREEAIKQLRK-------LQAQMKDFQRELEDARAS-RDEIFATAKENEKK 1681
Query: 366 NQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWL------MNEEEAKDLIARAFDV 419
+SL +D +L ++A + L +E E+ ++E + L AR +
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 420 DRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPES 479
+ + N+ +S + +K ATQ E++ S E E + A+
Sbjct: 1742 EEELEEEQ-------------GNMEAMSDRVRK-ATQQAEQL---SNELATERSTAQKN- 1783
Query: 480 YLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIES 539
+ +Q E+ K + L + G ++SK S + LE L +E
Sbjct: 1784 --ESARQQLERQNKELRSKLHEMEG-AVKSKFKSTIAALEAKIAQLEE--------QVEQ 1832
Query: 540 EDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKE 599
E + LK + +L L E ++AEQ + + EK
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEIL-----------------LQVEDERKMAEQYKEQAEKG 1875
Query: 600 ESLVEGEKEEEEETPPSPWVIHPN 623
+ V+ K + EE I+ N
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINAN 1899
Score = 37.4 bits (85), Expect = 0.051
Identities = 102/524 (19%), Positives = 200/524 (38%), Gaps = 85/524 (16%)
Query: 245 EQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQI------- 297
E+ +QA EL+ R +K E+ K+L ++ EE N+++ +L+ + ++
Sbjct: 851 EEEMQAKE-DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 298 ----------LEQQLQQRKAI--------YQLNQEKLEYNLQVL----KKRDEESTVIKS 335
LE+ L + +A QL E+ + Q+L + +EE+ K
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 336 QQKR-----KINRLHD---ILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAM 387
Q ++ KI +L D ++++ +K +K+ K +E LT++ + K L K
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 388 -RHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPI 446
+H ++I + E+ L EE+++ + + L A DF
Sbjct: 1030 NKHESMISE---LEVRLKKEEKSRQELEKL----------KRKLEGDASDF--------- 1067
Query: 447 SQQPQKSATQIVE-EMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGF 505
+Q QI E +M + +EEE + A A L +I++K L + + G
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALAR------LDDEIAQK--NNALKKIRELEGH 1119
Query: 506 L--IESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQ 563
+ ++ L S + E L AL E ED L L+
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT----------QQELR 1169
Query: 564 IKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESL---VEGEKEEEEETPPSPWVI 620
K + ++ K +++E + E ++ E + + E L +E K + + +
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 621 HPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDAL 680
+ E V+G K +++ V++ + + L + +
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 681 YTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLNSKIN 724
+ + + KL + +SL Q + Q LLQ+ K+N
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Score = 35.0 bits (79), Expect = 0.25
Identities = 79/403 (19%), Positives = 164/403 (40%), Gaps = 66/403 (16%)
Query: 339 RKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKF 398
R ++ +L R + Q K+ +E Q ++ + KEL++ +H L +++
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQ--KHSQLTEEKNL 891
Query: 399 W--------EIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQP 450
E++ EE L A+ +++ I+H L QQ
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL----------EEEEDRGQQL 941
Query: 451 QKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRI---LMLLCDESGFLI 507
Q ++ ++ML E+ E EEAA + L L K +E K++ ++++ D++ L
Sbjct: 942 QAERKKMAQQMLDLEEQLEEEEAARQK---LQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 508 ESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPC 567
+ + L LE+ R+ + + L E E+ L LK + + S L+++
Sbjct: 999 KERKL-----LEE------RISDLTTNLA-EEEEKAKNLTK--LKNKHESMISELEVR-L 1043
Query: 568 SQASMEKASMEETSTRSELELAEQTEMEGEKEESLVE-----GEKEEEEETPPS---PWV 619
+ + +E+ + E + ++ E + + + E +KEEE + + +
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 620 IHPNDVLK---ILEAFVMGLKKPRDSRAPLR--VQKNVRDNSKDSEYWQALTTVIPSSKQ 674
N+ LK LE + L++ DS R +K RD ++ E + K
Sbjct: 1104 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE----------ALKT 1153
Query: 675 NLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQ 717
L D L + + L + ++ + +L+++ +A +Q+
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 68.6 bits (166), Expect = 2e-11
Identities = 124/577 (21%), Positives = 262/577 (45%), Gaps = 81/577 (14%)
Query: 62 KKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIE 121
KK E++++ ++++E+ +L KL +L + + +D R++H +E+ ++ Q+++
Sbjct: 212 KKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMH--IEQLGLQSQKVQ 269
Query: 122 KLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQE 181
L +++ ++K ITSK +E +QK + E+ E K S+ +E
Sbjct: 270 DLTQKLREEEEKLKAITSKSKEDRQKLLKLEV-------------DFEHKASRFSQEHEE 316
Query: 182 LKTK---DDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAF---EVERQE 235
+ K + + + L+ + + +E +EE KN+ K EEL + E
Sbjct: 317 MNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKA-EEELQELRDKIAKGECGNSS 375
Query: 236 LLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDV 295
L+A + ++ L E+E + + K E ++L R+++ + EE++ +++LE
Sbjct: 376 LMAEVENLRKRVL------EMEGKDEEITKTESQCREL-RKKLQE-EEHHSKELRLE--- 424
Query: 296 QILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKY 355
++LQ+R + EKLE + K E T + +++ N D+LN L
Sbjct: 425 ---VEKLQKRMS----ELEKLE---EAFSKSKSECTQLHLNLEKEKNLTKDLLNEL---- 470
Query: 356 AKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFA--LIDDEKFWEIWLMNEEEAKDLI 413
+ +K +E + S ++ + K+ ++ F L+D+ K + EE D +
Sbjct: 471 -EVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGL 529
Query: 414 ARAFDVDR---IIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEML--MRSEEE 468
+ F V++ + T L + L + ++ + T+ +E++ ++SEEE
Sbjct: 530 NKNFKVEQGKVMDVTEKL-----IEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEE 584
Query: 469 EAEEAAAEP-------ESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQN 521
++ E + + ++ ++I+ +++ L C E ++K+ L L +E+
Sbjct: 585 KSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPE-----DNKIKELTLEIERL 639
Query: 522 ECYLLRLDAIFSALGIESEDDLYKLVNFFL--KYRAHRLSSSL-QIKPCSQASMEKASME 578
+ L +L+ + L +++ED+ +L F + +A+ LS L +IK Q + KA +
Sbjct: 640 KKRLQQLEVVEGDL-MKTEDEYDQLEQKFRTEQDKANFLSQQLEEIK--HQIAKNKAIEK 696
Query: 579 ETSTRSELELAEQTEMEGEKEESL---VEGEKEEEEE 612
E EL + +E K L V+ KE+ E
Sbjct: 697 GEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHE 733
Score = 58.5 bits (140), Expect = 2e-08
Identities = 84/370 (22%), Positives = 168/370 (45%), Gaps = 46/370 (12%)
Query: 53 EALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEE 112
E L + + ++ EE SKS + + L L K +L+ ++V + RV+E
Sbjct: 426 EKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEV------VKSRVKE 479
Query: 113 EEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQ---KRIPQELWEM--LNTQ-QLHCAG 166
E R+EK E +K K T + ++ ++I QE ++ LN ++
Sbjct: 480 LECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGK 539
Query: 167 LLEDKNKLISELQQELKTKDD--QYVKDLKKQSDDICLLLERMEEQVKNV---MKTFREE 221
+++ KLI E ++ LK K + + V +L ++ D++ L+ EE+ + + ++
Sbjct: 540 VMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKR 599
Query: 222 LYNIEKAFEVERQELLASNKKKWEQALQAHNA---------------KELEYLNNRMKKV 266
L IE EVER+ ++K E N ++LE + + K
Sbjct: 600 LDGIE---EVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKT 656
Query: 267 EDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQ---LNQE---KLEYNL 320
ED QL ++ + ++ N + +LE+ ++ Q+ + KAI + ++QE + + L
Sbjct: 657 EDEYDQLEQKFRTEQDKANFLSQQLEE----IKHQIAKNKAIEKGEVVSQEAELRHRFRL 712
Query: 321 QVLKKRDEESTVIKSQQK-RKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQ 379
+ K RD ++ V ++K ++ D L+ L+ Y+ ++F EE + + ++
Sbjct: 713 EEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNL 772
Query: 380 FKELQKAMRH 389
KEL+ + R+
Sbjct: 773 TKELELSKRY 782
Score = 47.4 bits (111), Expect = 5e-05
Identities = 117/571 (20%), Positives = 232/571 (40%), Gaps = 126/571 (22%)
Query: 63 KESEEDQSKSYKQKEESRLKLAKLL------LCGTELVTNI----QVAIDIREIHR-RVE 111
K S E + K+ K E S+ L +LL L E V ++ + ++ E H E
Sbjct: 60 KTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAE 119
Query: 112 EEEIKR--QRIEKLENEVKTSQDKFDEITSKWE--EGKQKRIPQELWEMLNTQQLHCAGL 167
E++ R R L E +D +++ S+ + E KQK + + E L L
Sbjct: 120 PEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQL---------L 170
Query: 168 LEDK--NKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNI 225
L +K + + EL+ E K K Y+ +SDD LLE+ E++K +++
Sbjct: 171 LAEKCHRRTVYELENE-KHKHTDYMN----KSDDFTNLLEQERERLKKLLEQ-------- 217
Query: 226 EKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYN 285
EKA++ +++ NAK L L + + K++ + L +R E+
Sbjct: 218 EKAYQARKEK---------------ENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLG 262
Query: 286 MIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLH 345
+ K++ Q L ++ ++ KAI ++E + L+ ++ + K +R
Sbjct: 263 LQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLK-----------LEVDFEHKASRFS 311
Query: 346 DILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMN 405
+ +K A Q + N+ L L + +EL++ ++ ++E
Sbjct: 312 QEHEEMNAKLANQ----ESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEEL-------- 359
Query: 406 EEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRS 465
+E +D IA+ G + + + + ++
Sbjct: 360 -QELRDKIAK----------------------------GECGNSSLMAEVENLRKRVLEM 390
Query: 466 EEEEAEEAAAEPESYLDLPKQISEKT--TKRILMLLCDESGFLIESKLLSLLLPLEQNEC 523
E ++ E E + +L K++ E+ +K + + + + E + L ++EC
Sbjct: 391 EGKDEEITKTESQC-RELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSEC 449
Query: 524 YLLRLDAIFSALGIESEDDLYK-LVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETST 582
L L+ +E E +L K L+N + S ++ CS++ +EKA E S
Sbjct: 450 TQLHLN-------LEKEKNLTKDLLN-----ELEVVKSRVKELECSESRLEKA---ELSL 494
Query: 583 RSEL-ELAEQTEMEGEKEESLVEGEKEEEEE 612
+ +L +L T M ++ ++++E K+EE +
Sbjct: 495 KDDLTKLKSFTVMLVDERKNMMEKIKQEERK 525
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 67.8 bits (164), Expect = 3e-11
Identities = 89/382 (23%), Positives = 169/382 (44%), Gaps = 48/382 (12%)
Query: 50 RRREALGEYLDGKKESEEDQSKSYKQKEESRLKL---AKLLL-----CGTELVTNIQVAI 101
+ +E L + +KE EE ++K + +L++ A L C + T IQ+
Sbjct: 862 KTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEA 921
Query: 102 DIREIHRRVEEEE-------IKRQRIEKLENEVKTSQDKFDEITSKWE------EGKQKR 148
I+E+ R E+EE K++++E +E+K D + +K E E K K
Sbjct: 922 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 981
Query: 149 IPQE---LWEMLNTQQLHCAGLLEDKNKLISELQQE---------LKTKDDQYVKDLK-- 194
+ +E L E + L E + + +LQ E KTK +Q V DL+
Sbjct: 982 LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGS 1041
Query: 195 -KQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFE-----VERQELLASN---KKKWE 245
+Q +C+ LER + +++ +K +E + E + ++++E SN K + E
Sbjct: 1042 LEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDE 1101
Query: 246 QALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQR 305
QAL K+++ L R++++E+ + R ++ + + +LE+ + LE+
Sbjct: 1102 QALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1161
Query: 306 KAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
A ++N +K E Q +++ EEST+ + + H + ++ +QI Q
Sbjct: 1162 SAQIEMN-KKREAEFQKMRRDLEESTLQHEATAAALRKKH---ADSVAELGEQIDSLQRV 1217
Query: 366 NQSLTSDYKRLVMQFKELQKAM 387
Q L + L M+ +L M
Sbjct: 1218 KQKLEKEKSELKMEINDLASNM 1239
Score = 46.6 bits (109), Expect = 8e-05
Identities = 75/355 (21%), Positives = 154/355 (43%), Gaps = 40/355 (11%)
Query: 32 SQERIQARRLRIAARLEARRREALGEY---LDGKKESEEDQSKSYK----QKEESRLKLA 84
++E Q R + + +AR GE+ LD K S+ + Q EE + +L
Sbjct: 1265 TKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 85 KLLLCGTELVTNIQVAID----IREIHRRVEEEEIKRQR-IEKLENEVKTSQDKFD---- 135
+ + L +Q A +RE + +E + + QR + K +EV + K++
Sbjct: 1325 EETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAI 1384
Query: 136 EITSKWEEGKQKRIP--QELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDL 193
+ T + EE K+K Q+ E + CA L + K +L +E++ + +
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVE------- 1437
Query: 194 KKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNA 253
+S+ C+ L++ + V+ ++++ +E + EL AS K+ + +
Sbjct: 1438 --RSNAACIALDKKQRNFDKVLAEWKQK-------YEETQAELEASQKESRSLSTELFKV 1488
Query: 254 KEL-EYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLN 312
K E + ++ ++ K L +Q I D E K +++ +++QL K+ Q +
Sbjct: 1489 KNAYEESLDHLETLKRENKNL-QQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTS 1547
Query: 313 QEKLEYNLQ----VLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQ 363
E+ E +L+ + + E +KS+ RKI + L+ L+ + + ++ Q
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQ 1602
Score = 32.7 bits (73), Expect = 1.2
Identities = 41/226 (18%), Positives = 99/226 (43%), Gaps = 28/226 (12%)
Query: 121 EKLENEVKTSQDKFDEITSKWEEGKQKR---------IPQELWEMLNTQQLHCAGLLEDK 171
+KLE ++ Q + ++I + ++K + +EL + +T H + ++
Sbjct: 1732 KKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNM 1790
Query: 172 NKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEV 231
+ + +LQ L + +K KKQ + + +E +V++ E+ +N+E +
Sbjct: 1791 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVES------EQKHNVEAVKGL 1844
Query: 232 ERQELLASNKKKWEQALQAHNAKELEYLNNRMK-KVEDYEKQLNRQRIWDCEEYNMIKIK 290
+ E + ++ N L+ L ++++ KV+ Y++Q + EE + + +
Sbjct: 1845 RKHERRV-KELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAE-----EAEEQSNVNLA 1898
Query: 291 LEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQ 336
+ +Q ++ ++R I + KL +K R+ + VI +
Sbjct: 1899 KFRKLQHELEEAKERADIAESQVNKLR-----VKSREVHTKVISEE 1939
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 67.0 bits (162), Expect = 6e-11
Identities = 71/365 (19%), Positives = 166/365 (45%), Gaps = 48/365 (13%)
Query: 62 KKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIE 121
+K EE++ + ++++E K+ + IRE ++ E+E K R E
Sbjct: 411 EKRQEEEKIREQEKRQEQEAKMWRQ-------------EEKIREQEEKIREQEKKMWRQE 457
Query: 122 KL--ENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQ 179
+ E E ++K E W + ++ +E+W +++H E + K+ Q
Sbjct: 458 EKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQ--KEKMH-----EQEEKI--RKQ 508
Query: 180 QELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREE--LYNIEKAFEVERQELL 237
+E + ++ +++ +++ + + R EE+++ + +REE ++ EK +E E+++
Sbjct: 509 EEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQ-- 566
Query: 238 ASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQI 297
K W Q + +E + + ++ ++Q +++W EE KI+ EQ+ +I
Sbjct: 567 EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEE----KIR-EQEEKI 621
Query: 298 LEQQ---------LQQRKAIYQLNQEKL---EYNLQVLKKRDEESTVIKSQQKRKINRLH 345
EQ+ +++++ + Q +EK+ E + +++ +E +Q+ KI
Sbjct: 622 QEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQE 681
Query: 346 DILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFW--EIWL 403
+ K +Q + QE+ + + +++ Q +++Q+ +EK W E+ L
Sbjct: 682 KKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR-QEEKMWEQEVRL 740
Query: 404 MNEEE 408
+EE
Sbjct: 741 RQQEE 745
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/334 (17%), Positives = 151/334 (45%), Gaps = 37/334 (11%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
Q+++QA + L++ + L + E E ++ +Q+EE + + + E
Sbjct: 260 QQQLQAEADHLGKELQS-----VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE 314
Query: 93 LVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWE-EGKQKRIPQ 151
+ + I +E R +EE+++RQ E E K + + WE E K +R +
Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE----EMMWEKEEKMRRQEE 370
Query: 152 ELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQV 211
+WE + ++ +K + I EL++++ ++ ++ K+Q ++ E+ +EQ
Sbjct: 371 MMWEK-EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ- 428
Query: 212 KNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEK 271
+++ E+ + +++ KK W Q + H +K+ + EK
Sbjct: 429 -------EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH----------EQEKIREEEK 471
Query: 272 QLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEEST 331
+ ++ +W EE KI ++++ ++++ +++ + +EK+ + +++++E+
Sbjct: 472 RQEQEEMWRQEE----KIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKI- 526
Query: 332 VIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
+Q+ K+ R + + + ++ K ++E
Sbjct: 527 ---REQEEKMWRQEEKIREQEEMWREEEKMHEQE 557
Score = 57.8 bits (138), Expect = 4e-08
Identities = 71/366 (19%), Positives = 169/366 (46%), Gaps = 45/366 (12%)
Query: 76 KEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFD 135
KE++ KL L +E ++ ++++E+ R++E ++ + ++L+ E +
Sbjct: 220 KEKNAKLQEKLQLVESE---KSEIQLNVKELKRKLERAKLLLPQ-QQLQAEADHLGKELQ 275
Query: 136 EITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKK 195
+++K + ++ ELW LN QQ E+K + E QE + K + + +++
Sbjct: 276 SVSAKLQAQVEEN---ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIRE 332
Query: 196 QSDDICLLLERMEEQV-KNVMKTFREELYNIEKAFEVERQELLASNKKK---------WE 245
Q + + R EE + + K R+E EK ++ RQE + K++ WE
Sbjct: 333 QEEK----MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 388
Query: 246 QALQAHNAKELEYLNNRMKKV-EDYEKQLNRQRIWDCEEYNMIKIKL---EQDVQILEQQ 301
+ +ELE + +K+ E EK+ ++I + E+ + K+ E+ ++ E++
Sbjct: 389 ---KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 302 LQQRKAIYQLNQEKL--EYNLQVLKKRDEESTVIKSQ-----------QKRKINRLHDIL 348
+++++ +EK+ + ++ +KR E+ + + + QK K++ + +
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKI 505
Query: 349 NNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHF----ALIDDEKFWEIWLM 404
K +Q ++ +E+ + + +++ Q +++++ + + + EK WE
Sbjct: 506 RKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKR 565
Query: 405 NEEEAK 410
E+E K
Sbjct: 566 QEQEDK 571
Score = 37.7 bits (86), Expect = 0.039
Identities = 46/227 (20%), Positives = 96/227 (42%), Gaps = 37/227 (16%)
Query: 31 NSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCG 90
+ QE+I R + R+E E + ++E Q + +++EE R + + +
Sbjct: 554 HEQEKIWEEEKRQEQEDKMWRQE---EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 91 TELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIP 150
E + + I +E R +EE+I+ Q E + ++K E K E ++K
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQ-----EEMTQEQEEKMGEQEEKMCEQEEKMQE 665
Query: 151 QE--LWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERME 208
QE +W +QE K ++ + K +++Q + I E M+
Sbjct: 666 QEETMW------------------------RQEEKIREQE--KKIREQEEKIREQEEMMQ 699
Query: 209 EQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKE 255
EQ + + + E++ E+ + + +++ +K WEQ ++ +E
Sbjct: 700 EQEEKMWEQ-EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 745
Score = 36.6 bits (83), Expect = 0.086
Identities = 29/162 (17%), Positives = 84/162 (51%), Gaps = 7/162 (4%)
Query: 227 KAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNM 286
K E E ++L++ W+ A + A L + + KK + Y ++L ++R D +
Sbjct: 154 KQLEGEARDLISRLHDSWKFAGELEQA--LSAVATQKKKADRYIEELTKER--DALSLEL 209
Query: 287 IKIKL-EQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQ--KRKINR 343
+ + +++++ +LQ++ + + + +++ N++ LK++ E + ++ QQ + + +
Sbjct: 210 YRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 269
Query: 344 LHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQK 385
L L ++ +K Q+++ + N+ +++ Q +++Q+
Sbjct: 270 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 311
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 67.0 bits (162), Expect = 6e-11
Identities = 159/766 (20%), Positives = 321/766 (41%), Gaps = 122/766 (15%)
Query: 30 DNSQERIQARRLRIAARLEA--RRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLL 87
D +++ ++ ++ LE R+ + L E + E + +++ + + EE R +LA
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLA--- 914
Query: 88 LCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIE----KLENEVKTSQDKFDE------- 136
++ + ++ RVEEEE + Q ++ K++ ++ +++ DE
Sbjct: 915 ------AKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK 968
Query: 137 --ITSKWEEGKQKRIPQE--LWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKD 192
+ E K K++ +E L E N++ + L+ED+ I+E +L ++++ K+
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR---IAECSSQL-AEEEEKAKN 1024
Query: 193 LKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQEL---------------- 236
L K + +++ +EE++K KT R+EL ++ + E +L
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKT-RQELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083
Query: 237 -LASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQL-NRQRIWDCEEYNMIKIK---- 290
LA +++ + AL A E + NN +K V + + Q+ Q ++ E+ + K +
Sbjct: 1084 QLAKKEEELQGAL-ARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 291 -LEQDVQILEQQLQQRKAIYQLNQE---KLEYNLQVLKKRDEESTVIKSQQKRKINRLHD 346
L ++++ L+ +L+ QE K E + LKK EE T Q + + + H
Sbjct: 1143 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202
Query: 347 ILNNLRSKYAKQIKQF----QEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIW 402
S+ +Q K+F ++ Q L +D K L + K LQ+ + K ++
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE----SEHKRKKL- 1257
Query: 403 LMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFW-FLNNVGPISQQPQKSATQIVEEM 461
+ + ++L A+ + DR+ + L A L+NV + ++ +K + ++
Sbjct: 1258 ---DAQVQELHAKVSEGDRL----RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 462 L-MRSEEEEAEE-AAAEPESYLDLPKQI----SEKTTKRILMLLCDESGFLIESKLLSLL 515
+ S+ ++ +E E L+L +I EK + + +E+ +E ++L+L
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370
Query: 516 LPLEQNECYLLRLDAIFSALG-IESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEK 574
L + + LG IES ++ K L A LS L+ K + +EK
Sbjct: 1371 SQLADTK------KKVDDDLGTIESLEEAKKK----LLKDAEALSQRLEEKALAYDKLEK 1420
Query: 575 ASMEETSTRSEL--------ELAEQTEMEGEKEESLVEGEKE------EEEETPPSPWVI 620
+L ++A E + +K + L+ EK EE + +
Sbjct: 1421 TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE 1480
Query: 621 HPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDAL 680
L + A L+ + R K +R + +D + SSK ++ +
Sbjct: 1481 KETKALSLARALEEALEAKEEFE---RQNKQLRADMED----------LMSSKDDVGKNV 1527
Query: 681 YTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLNSKINSE 726
+ LEK L Q+ + + + LE+ ELQA L ++N +
Sbjct: 1528 H-ELEKSKRALEQQVEEM--RTQLEELEDELQATEDAKLRLEVNMQ 1570
Score = 63.9 bits (154), Expect = 5e-10
Identities = 158/699 (22%), Positives = 285/699 (40%), Gaps = 140/699 (20%)
Query: 48 EARRREALGEYLDGKKESEEDQSKSYKQKEESRLKL--AKLLLCG--TEL---VTNIQVA 100
E + + L + + ++ D + K++E++R +L AK L G T+L + +Q
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077
Query: 101 IDIREIHRRVEEEEIKR----------------QRIEKLENEVKTSQDKFD-EITSKWEE 143
ID ++ +EEE++ + + +L+ ++ Q+ F+ E S+ +
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 144 GKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKK-------- 195
KQKR E E L T+ LED + QQEL+TK +Q V +LKK
Sbjct: 1138 EKQKRDLSEELEALKTE-------LEDTLDTTAA-QQELRTKREQEVAELKKALEEETKN 1189
Query: 196 ---QSDDI----CLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLAS--------- 239
Q D+ LE + EQ++ K F+ L ++ E + +EL
Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQA-KRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248
Query: 240 ----NKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWD-----CEEYNMIKIK 290
+KK + +Q +AK E +R+ +VE EK Q D EE IK
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSE--GDRL-RVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 291 LEQDVQILEQQLQQRKAIYQ-LNQEKLEYNLQVLKKRDEESTVIKSQQKRKINR--LHDI 347
+D LE QLQ + + Q ++KL + ++ + +E++++ + Q++ + R L
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ 1365
Query: 348 LNNLRSKYAKQIKQFQEE---NQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLM 404
+ L+S+ A K+ ++ +SL K+L+ + L + + AL D+
Sbjct: 1366 VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL------- 1418
Query: 405 NEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMR 464
E+ K+ + + D D + H V ++ QK Q++ E
Sbjct: 1419 --EKTKNRLQQELD-DLTVDLDH------------QRQVASNLEKKQKKFDQLLAEEKSI 1463
Query: 465 SEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECY 524
S E AE E+ EK TK + + E +E+K E+ E
Sbjct: 1464 SARYAEERDRAEAEA--------REKETKALSLARALEEA--LEAK--------EEFERQ 1505
Query: 525 LLRLDAIFSALGIESEDDLYKLVNFF-------------LKYRAHRLSSSLQIKPCSQAS 571
+L A L + S+DD+ K V+ ++ + L LQ ++
Sbjct: 1506 NKQLRADMEDL-MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564
Query: 572 MEKASMEETSTRSELELAEQTEMEGEKEESLV----EGEKEEEEETPPSPWVIHPNDVLK 627
+E +M+ + E +L + E EK+ L+ E E E E+E + ++
Sbjct: 1565 LE-VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKME 1623
Query: 628 I----LEAFVMGLKKPRDS--RAPLRVQKNVRDNSKDSE 660
I LEA + K RD + ++Q ++D ++ E
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662
Score = 55.5 bits (132), Expect = 2e-07
Identities = 92/415 (22%), Positives = 172/415 (41%), Gaps = 68/415 (16%)
Query: 33 QERIQARRLRIAARLEARRRE----------ALGEYLDGKKESEEDQSKSYKQKEESRLK 82
++ I AR R EA RE AL E L+ K+E E +Q ++ R
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE-------RQNKQLRAD 1512
Query: 83 LAKLLLCGTELVTNIQVAIDIREIHRRVEEE-EIKRQRIEKLENEVKTSQD-------KF 134
+ L+ ++ N+ ++ + R +E++ E R ++E+LE+E++ ++D
Sbjct: 1513 MEDLMSSKDDVGKNVH---ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 135 DEITSKWEEGKQKRIPQ--ELWEMLNTQQLHCAGLLEDKNK-----LISELQQELKTKD- 186
+ +++E Q R Q E +L Q LED+ K + S+ + E+ KD
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629
Query: 187 DQYVKDLKKQSDDICLLLERMEEQVKNVMKTF------REELYNIEKAFE---------- 230
+ ++ K D++ L +++ Q+K+ + R+E++ K E
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 231 VERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDY-EKQLNRQRIWDCEEY----- 284
++ QE LAS+++ A Q + E N+ K EK+ RI EE
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 285 -NMIKI-----KLEQDVQILEQQLQQRKAIYQLN----QEKLEYNLQVLKKRDEESTVIK 334
NM + K V L +L ++ Q + Q+ N ++ K E +K
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK 1809
Query: 335 SQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRH 389
S+ K I+ L + L + ++ K+ N+ + K+L F +++ RH
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRH 1864
Score = 46.6 bits (109), Expect = 8e-05
Identities = 78/349 (22%), Positives = 150/349 (42%), Gaps = 52/349 (14%)
Query: 175 ISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVM--KTFREELYNIEKAFEVE 232
++ ++EL+ KD++ +K +K++ + LE ME + + ++ K E E E
Sbjct: 847 VTRQEEELQAKDEELLK-VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 233 RQEL---LASNKKKWEQALQ------AHNAKELEYLNNRMKK----VEDYEKQLN----- 274
+E+ LA+ K++ E+ L + + L N KK ++D E+QL+
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 275 RQRIWDCEEYNMIKI-KLEQDVQILEQQLQQRKAIYQLNQEKL-EYNLQVLKKRDEESTV 332
RQ++ + KI K+E+++ +LE Q + +L ++++ E + Q+ ++ ++ +
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 333 IKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFAL 392
K + K+++ + D+ L+ K K ++ ++ + L + L Q ELQ A
Sbjct: 1026 AKIRNKQEV-MISDLEERLK-KEEKTRQELEKAKRKLDGETTDLQDQIAELQ------AQ 1077
Query: 393 IDDEKFWEIWLMNEEEAKDLIARAFDVD-------RIIHTHHLGLPWAAPDFWFLNNVGP 445
ID+ K EEE + +AR D +++ + DF
Sbjct: 1078 IDELKLQ--LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDF-------- 1127
Query: 446 ISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKR 494
+ A++ E R EE E E E LD E TKR
Sbjct: 1128 ----ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 67.0 bits (162), Expect = 6e-11
Identities = 162/766 (21%), Positives = 327/766 (42%), Gaps = 126/766 (16%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
+++++A R +LE + + +D + + ++ + K K++ E AK+ E
Sbjct: 1045 EKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKI---DDE 1101
Query: 93 LVTNIQVAIDIREIHRRVEE--EEIK-----RQRIEK----LENEVKTSQDKFDEIT--- 138
V ++Q I+E+ R+EE EEI+ R +IEK L E++ ++ +E +
Sbjct: 1102 QVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGAT 1161
Query: 139 ------SKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQEL------KTKD 186
+K E + +++ ++L E + A L + + ++EL +++ K K
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKL 1221
Query: 187 DQYVKDLKKQSDDICLLLERMEEQVKNVMKTFR--EELYNIEKAFEVERQELLASNKKKW 244
++ +LK + DD+ +E + + N+ +T R E+ ++ KA + E+Q L +
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD-EQQTQLIHDLNMQ 1280
Query: 245 EQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQ 304
+ LQ N + L++R+++ E QL + + + +LE+ + +E++ +
Sbjct: 1281 KARLQTQNGE----LSHRVEEKESLISQLTKSK-------QALTQQLEELKRQMEEETKA 1329
Query: 305 RKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQE 364
+ A+ Q ++ +L+++ EE K++ +R +++ + + R+KY Q E
Sbjct: 1330 KNAMAHALQSS-RHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388
Query: 365 ENQSLTSDYKRLVMQFKELQK----AMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVD 420
E L K+L + +E ++ A A ++ K + E +DL+ D++
Sbjct: 1389 E---LEEAKKKLAQRLQEAEENTETANSKCASLEKTK-----QRLQGEVEDLMR---DLE 1437
Query: 421 RIIHTHHLGLPWAAPDF------W--FLNNVGPISQQPQKSATQIVEEML-MRSEEEEA- 470
R HT L +F W L+ + QK + + E+ MR+ EE
Sbjct: 1438 R-SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV 1496
Query: 471 -------EEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNEC 523
E E DL +QI+E T K + +++ L+E + L + LE+ E
Sbjct: 1497 DQLETLRRENKNLQEEISDLTEQIAE-TGKNLQE--AEKTKKLVEQEKSDLQVALEEVEG 1553
Query: 524 YL-----------LRLDAIFSALG---IESEDDLYKLVNFFLKYRAHRLSSSLQ------ 563
L L L + S L IE ++++ + LK + R + +LQ
Sbjct: 1554 SLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQ-----LKRNSQRAAEALQSVLDAE 1608
Query: 564 IKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESL--VEGEKEEEEETPPSPWVIH 621
I+ + A K ME E++L E ++ L V+G+ ++ + +H
Sbjct: 1609 IRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQ--------LH 1660
Query: 622 PNDVLKILEAFVMGLK-KPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDAL 680
+D L+ E L R + L + ++ + +E + L S+Q L D
Sbjct: 1661 LDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRL------SEQELLD-- 1712
Query: 681 YTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLNSKINSE 726
A ++ L+ +Q L+ LE + QA ++ + N+E
Sbjct: 1713 --ASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAE 1756
Score = 45.8 bits (107), Expect = 1e-04
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 63/300 (21%)
Query: 111 EEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQL-----HCA 165
+E ++ E+ + E+ S+ + E+ K Q++ +L T+ L C
Sbjct: 851 KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCE 910
Query: 166 GL-----------------LEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERME 208
GL LE++ ++ SEL + + +D+ LK+ DD+ L L ++E
Sbjct: 911 GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDK-CSSLKRDIDDLELTLTKVE 969
Query: 209 EQ---VKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKK 265
++ +N +K EE+ +E+ S K +++LQ + + L+ L K
Sbjct: 970 KEKHATENKVKNLSEEMTALEENI---------SKLTKEKKSLQEAHQQTLDDLQVEEDK 1020
Query: 266 VEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRK---AIYQLNQEKLEYNLQV 322
V K I KLEQ LE L+Q K A + + KLE +L++
Sbjct: 1021 VNGLIK---------------INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKM 1065
Query: 323 LKKRDEESTVIKSQQKRKINRLHDILNNLRSK----------YAKQIKQFQEENQSLTSD 372
++ + K Q + K+ + L+ L++K + K+IK+ Q + L +
Sbjct: 1066 SQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEE 1125
Score = 32.7 bits (73), Expect = 1.2
Identities = 48/219 (21%), Positives = 94/219 (42%), Gaps = 30/219 (13%)
Query: 31 NSQERIQARRLRIAARLEARRREALGEYLDGKKESEED--QSKSYKQKEESRLKLAKLLL 88
N++++++A + A +E +E+ KK + ++ K+++++ L ++
Sbjct: 1729 NTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Query: 89 CGTELVTNIQVAIDIREIHRRVEEEEIK----RQRIEKLENEVKTSQDKFDEITSKWEEG 144
+ V ++Q HR E E++ +++I+KLEN V+ +++ D + E
Sbjct: 1789 NLEQTVKDLQ--------HRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEA 1840
Query: 145 KQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLL 204
+ E T Q E+ +K I L Q+L K VK K+Q+
Sbjct: 1841 LKGAHKYERKVKEMTYQ------AEEDHKNILRL-QDLVDKLQAKVKSYKRQA------- 1886
Query: 205 ERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKK 243
E EEQ + R + +E+A ER ++ S K
Sbjct: 1887 EEAEEQANTQLSRCRRVQHELEEA--AERADIAESQVNK 1923
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 67.0 bits (162), Expect = 6e-11
Identities = 94/442 (21%), Positives = 191/442 (43%), Gaps = 48/442 (10%)
Query: 6 SLEALDPNVDEHLSTQILAPSVHSDNSQERIQAR-RLRIAARLEARRREALGEYLDGKKE 64
+++ L +D+ ++ S H + E AR RL+ A + +G L +
Sbjct: 216 NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIG-MLQATQM 274
Query: 65 SEE------DQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQ 118
++E + KS + S+L+ + L + + I E+ ++V E KR
Sbjct: 275 TQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEA--KRT 332
Query: 119 RIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISEL 178
+ E E E+K Q + +E ++ E K + + W+ + + + DK KL +L
Sbjct: 333 QQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDL 392
Query: 179 QQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQEL-- 236
+++ KD +++ K Q LE ++E +++ + T +E+ +++ Q L
Sbjct: 393 EEQ-HNKDKLNLEEDKNQLQQ---ELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGS 448
Query: 237 ---LASNKKKWEQALQAHNAKELEYLNNRMKKVED----------YEKQLNRQRIWDCEE 283
L ++ + ++ LQ EL+ + +K+ +D E+Q + + I +E
Sbjct: 449 AEGLIASLQDSQERLQ----NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 504
Query: 284 YNMIKI-KLEQDVQI-----LEQQLQQRKAIYQLNQE--KLEYNLQVLKKRDEESTVIKS 335
+K+ K+ D++I L Q+ + + +L E K Q+L+ +D E +
Sbjct: 505 EEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARD 564
Query: 336 QQKRKINRLHDILNNLRSKYAKQIKQFQEENQSL----TSDYKRLVMQFKEL--QKAMRH 389
++K+ L + ++ L+ Q+ Q Q Q L T + +RL + +EL Q RH
Sbjct: 565 SWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRH 624
Query: 390 FALIDDEKFWEIWLMNEEEAKD 411
+L + M EE+ K+
Sbjct: 625 KSL-KEAHVLAFQTMEEEKEKE 645
Score = 54.3 bits (129), Expect = 4e-07
Identities = 141/690 (20%), Positives = 280/690 (40%), Gaps = 98/690 (14%)
Query: 94 VTNIQVAIDIREIHRRV----EEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRI 149
V ++Q+ + + + R V E EEI+R+ EKL + + Q +F++ E Q
Sbjct: 16 VEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQL-QVQFEKDKRLALEDLQAAH 74
Query: 150 PQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICL----LLE 205
+E+ E+L +QQ H A + + + K +EL + V+ L K +++ L L+E
Sbjct: 75 RREIQELLKSQQDHSASVNKGQEK-----AEELHRME---VESLNKMLEELRLERKKLIE 126
Query: 206 RMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWE-----QALQAHNAKELEYLN 260
E ++ + EL ++++ + L AS +K+ + Q +A K + L
Sbjct: 127 DYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLK 186
Query: 261 NRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRK----AIYQLNQEKL 316
++ V+D L + C++ E +VQ+L++QL K A+ ++E +
Sbjct: 187 TELQMVQDEAGSL----LDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE-V 241
Query: 317 EYNLQVLKKRDEEST-----------VIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEE 365
E L ++R ++ ++++ Q + + D L + +S+ +++ Q +EE
Sbjct: 242 ESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKD-LESEKSRVNERLSQLEEE 300
Query: 366 NQSLTSDYKRL----VMQFKELQKAMRHFALIDDEKFWEIWLMN-----EEEAKDL-IAR 415
L S + L Q EL+K + A ++++E L N EEE L A
Sbjct: 301 RAFLRSKTQSLDEEQKQQILELEKKVNE-AKRTQQEYYERELKNLQSRLEEEVTQLNEAH 359
Query: 416 AFDVDRIIHTHHLGLPWA-----------APDFWFLNNVGPISQQPQKSATQIVEEMLMR 464
+ ++ + HH+ + D +N ++ + K+ Q E L
Sbjct: 360 SKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKE 419
Query: 465 SEEEEAEEAAAEPESYLDLPKQISEKT-TKRILMLLCDESGFLIESKLLSLLLPLEQNEC 523
E++ A E D+ ++ + + L+ +S ++++L L++ +
Sbjct: 420 VLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKD 479
Query: 524 YLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTR 583
LL ++ + E+ + + K + +++ L+IK E + + E
Sbjct: 480 ALLNVEGELEQERQQHEETIAAMKE-EEKLKVDKMAHDLEIKWTENLRQECSKLRE---- 534
Query: 584 SELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKILEAFVMGLKKPRDSR 643
EL Q E + + S + K+ E+ W D+L + +
Sbjct: 535 ---ELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLL----------K 581
Query: 644 APLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDALYTALEKYHLVLTQRAKLLLEN-- 701
L +Q S+ Q L +Q L L LE+ H QR K L E
Sbjct: 582 QNLEIQL-----SQSQTSLQQLQAQFTQERQRLTQEL-EELEEQH---QQRHKSLKEAHV 632
Query: 702 ---SSLEQQNTELQALLQQYLNSKINSELQ 728
++E++ + Q L+ +L K ++ELQ
Sbjct: 633 LAFQTMEEEKEKEQRALENHLQQKHSAELQ 662
Score = 50.4 bits (119), Expect = 6e-06
Identities = 86/419 (20%), Positives = 183/419 (43%), Gaps = 62/419 (14%)
Query: 31 NSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLL-C 89
+SQER+Q L+ + L + ++E ++ + KEE +LK+ K+
Sbjct: 458 DSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDL 517
Query: 90 GTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKL-------ENEVKTS-QDKFDEITSKW 141
+ N++ R++ EE K+ + +L +N + S Q K +++ ++
Sbjct: 518 EIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQI 577
Query: 142 EEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDIC 201
KQ Q + QQL A +++ +L EL+ EL+ + Q K LK+
Sbjct: 578 SLLKQNLEIQLSQSQTSLQQLQ-AQFTQERQRLTQELE-ELEEQHQQRHKSLKEAHVLAF 635
Query: 202 LLLERMEEQVKNVMKTFREELYNIE------------KAFEVERQELLASNKKKWEQALQ 249
+E +E+ + ++ ++ ++ E + F +E ++ L + + + E +
Sbjct: 636 QTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGK 695
Query: 250 AHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQI------------ 297
A A LN++ D + + Q E K++LE+ + I
Sbjct: 696 AMLASLRSELNHQHAAAIDLLRHNHHQ------ELAAAKMELERSIDISRRQSKEHICRI 749
Query: 298 --LEQQLQQRKA-IYQLNQE--KLEYNLQVLKK----RDEESTVIKSQQKRKINRLHDIL 348
L+++L+ R+ I +L++E L N+ L K + +E I+S+ ++I L
Sbjct: 750 TDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIR-----L 804
Query: 349 NNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEE 407
+ KY +++ + E+ + ++ K ++ + ++ K LI+D KF+++ L+N E
Sbjct: 805 EEMEEKYL--MRESKPEDIQMITELKAMLTERDQIIKK-----LIEDNKFYQLELVNRE 856
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 67.0 bits (162), Expect = 6e-11
Identities = 94/442 (21%), Positives = 191/442 (43%), Gaps = 48/442 (10%)
Query: 6 SLEALDPNVDEHLSTQILAPSVHSDNSQERIQAR-RLRIAARLEARRREALGEYLDGKKE 64
+++ L +D+ ++ S H + E AR RL+ A + +G L +
Sbjct: 336 NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIG-MLQATQM 394
Query: 65 SEE------DQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQ 118
++E + KS + S+L+ + L + + I E+ ++V E KR
Sbjct: 395 TQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEA--KRT 452
Query: 119 RIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISEL 178
+ E E E+K Q + +E ++ E K + + W+ + + + DK KL +L
Sbjct: 453 QQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDL 512
Query: 179 QQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQEL-- 236
+++ KD +++ K Q LE ++E +++ + T +E+ +++ Q L
Sbjct: 513 EEQ-HNKDKLNLEEDKNQLQQ---ELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGS 568
Query: 237 ---LASNKKKWEQALQAHNAKELEYLNNRMKKVED----------YEKQLNRQRIWDCEE 283
L ++ + ++ LQ EL+ + +K+ +D E+Q + + I +E
Sbjct: 569 AEGLIASLQDSQERLQ----NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 624
Query: 284 YNMIKI-KLEQDVQI-----LEQQLQQRKAIYQLNQE--KLEYNLQVLKKRDEESTVIKS 335
+K+ K+ D++I L Q+ + + +L E K Q+L+ +D E +
Sbjct: 625 EEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARD 684
Query: 336 QQKRKINRLHDILNNLRSKYAKQIKQFQEENQSL----TSDYKRLVMQFKEL--QKAMRH 389
++K+ L + ++ L+ Q+ Q Q Q L T + +RL + +EL Q RH
Sbjct: 685 SWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRH 744
Query: 390 FALIDDEKFWEIWLMNEEEAKD 411
+L + M EE+ K+
Sbjct: 745 KSL-KEAHVLAFQTMEEEKEKE 765
Score = 48.1 bits (113), Expect = 3e-05
Identities = 77/414 (18%), Positives = 185/414 (44%), Gaps = 65/414 (15%)
Query: 29 SDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLL 88
++N ++ R + + E ++ A+ + L K + S+++K E L LL
Sbjct: 642 TENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLK 701
Query: 89 CGTELVTNIQVAIDIREIHRRVEEEEIK-RQRIEKLENEVKTSQDKFDEI------TSKW 141
E+ + Q ++++ + +E + Q +E+LE + + E T +
Sbjct: 702 QNLEIQLS-QSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEE 760
Query: 142 EEGKQKRIPQELWEMLNTQQLHCAGL--LEDKNKLISELQQELKTKDDQYVKDLKKQSDD 199
E+ K++R + + QQ H A L L+D ++ E + + + +Q ++ L+ +
Sbjct: 761 EKEKEQRALEN-----HLQQKHSAELQSLKDAHR---ESMEGFRIEMEQELQTLRFE--- 809
Query: 200 ICLLLERMEEQVKNVMKTFREELYNIEKAFEVE-----RQELLASNKKKWEQALQAHNAK 254
+E++ K ++ + R EL N + A ++ + LA+ K + E+++ +
Sbjct: 810 -------LEDEGKAMLASLRSEL-NHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ 861
Query: 255 ELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQR-KAIYQLNQ 313
E++ ++ D +++L R R E + L +++ L ++L+ + K I ++
Sbjct: 862 SKEHIC----RITDLQEEL-RHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRS 916
Query: 314 E---KLEYNLQVLKKRDEESTVI--------KSQQKRKINRLHDILNNLRSKYAKQIKQF 362
E ++ + Q L KR E+ + K+ + N+ +++L + + +++
Sbjct: 917 ESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEM 976
Query: 363 QE---------ENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEE 407
+E E+ + ++ K ++ + ++ K LI+D KF+++ L+N E
Sbjct: 977 EEKYLMRESKPEDIQMITELKAMLTERDQIIKK-----LIEDNKFYQLELVNRE 1025
Score = 44.7 bits (104), Expect = 3e-04
Identities = 114/570 (20%), Positives = 232/570 (40%), Gaps = 101/570 (17%)
Query: 72 SYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQ 131
S +E LK++K + +T + A++ + + +K E+++ + ++
Sbjct: 33 SMDYSQEMHLKMSKKIA----QLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETR 88
Query: 132 DKFDEITSK-WEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDD--- 187
+K + SK EE +R Q L L ++ K + ++E + +D
Sbjct: 89 EKILQYKSKVTEELDLRRKIQVLESSLEDH-------IKMKQQALTEFEAYKHRVEDMQL 141
Query: 188 ----QYVKDLKKQSDDICLLLERMEEQVKNV-------MKTFREELYNIEKAFEVERQEL 236
Q+V+ + S ++ + + EE++++ K R L +++ A E QEL
Sbjct: 142 CAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQEL 201
Query: 237 L-------ASNKKKWEQALQAHNAKELEYLNN--------RMKKVEDYEKQLNRQRIWDC 281
L AS K E+A + H E+E LN R K +EDYE +LN+ + +
Sbjct: 202 LKSQQDHSASVNKGQEKAEELHRM-EVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYE 260
Query: 282 EEYNMIK---IKLEQDVQI-------LEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEEST 331
E + +K + + +Q L ++ Q ++AI + KL+ LQ++ +DE +
Sbjct: 261 RELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMV--QDEAGS 318
Query: 332 VIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFA 391
++ Q K+ I N KQ+ +E +L S +K + + ++ +
Sbjct: 319 LLDKCQ--KLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERL---- 372
Query: 392 LIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAA--PDFWFLNNVGPISQQ 449
+++A DL+ +A H+G+ A + ++ +
Sbjct: 373 --------------QQQASDLVLKA---------SHIGMLQATQMTQEVTIKDLESEKSR 409
Query: 450 PQKSATQIVEE-MLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIE 508
+ +Q+ EE +RS+ + +E + + L+L K+++E KR + ++
Sbjct: 410 VNERLSQLEEERAFLRSKTQSLDE--EQKQQILELEKKVNE--AKRTQQEYYERELKNLQ 465
Query: 509 SKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCS 568
S+L + L + L A + IE+ + A R LQ+
Sbjct: 466 SRLEEEVTQLNEAHSKTLEELAWKHHMAIEA-----------VHSNAIRDKKKLQMDLEE 514
Query: 569 QASMEKASMEETSTRSELELAEQTEMEGEK 598
Q + +K ++EE + + EL E+ +K
Sbjct: 515 QHNKDKLNLEEDKNQLQQELENLKEVLEDK 544
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 66.6 bits (161), Expect = 8e-11
Identities = 153/689 (22%), Positives = 270/689 (39%), Gaps = 129/689 (18%)
Query: 113 EEIKRQRIEKLENEV-------KTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCA 165
+E+K+ R +++++ Q K EI+ + E + + + E+ N Q +
Sbjct: 219 KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHRE-ELSDYEERIEELENLLQQGGS 277
Query: 166 GLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTF------- 218
G++E I E+Q+ ++ + V+ KK +E++E+++K++ K
Sbjct: 278 GVIETDLSKIYEMQKTIQVLQIEKVESTKK--------MEQLEDKIKDINKKLSSAENDR 329
Query: 219 -----REELYNIEKAFEVERQELLASNKKKWEQAL--QAHNAKELEYLNNRMKKVEDYEK 271
+E N+EK +E E L K + + Q+ E E + + VE+ +
Sbjct: 330 DILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFR 389
Query: 272 QLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAI-------YQLNQEKLEYNLQVLK 324
+Q + D E M L QD + E L+ + I L+QEK E + +LK
Sbjct: 390 L--QQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLK 447
Query: 325 KRDEESTVIKSQQKRKI---NRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFK 381
+E VIKS R I + LHD+ NL +K QE NQS+ S+ + L+ + +
Sbjct: 448 LNNEYE-VIKSTATRDISLDSELHDLRLNLEAKE-------QELNQSI-SEKETLIAEIE 498
Query: 382 EL----QKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDF 437
EL Q+A +H LI D+ L ++ D I D
Sbjct: 499 ELDRQNQEATKHMILIKDQ------LSKQQNEGDSIISKLKQD----------------- 535
Query: 438 WFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILM 497
LN+ Q + I +E+ ++ E+ E A L L KQ E + ++
Sbjct: 536 --LNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALND---LHLTKQKLEDKVENLVD 590
Query: 498 LL--CDESGFLIESKLLSLLLPLEQNECYLLRL-DAIFSALG------------------ 536
L ES I+ + L L + QNE L R+ + + +L
Sbjct: 591 QLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAE 650
Query: 537 ----------IESEDDLYKLVNFFLKYRAHRLSSSL-----QIKPC----SQASMEKASM 577
+E ++ K V F +K +L + Q++ C +Q S+EK ++
Sbjct: 651 VRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTI 710
Query: 578 EETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKILEAFVMGLK 637
ET + E+ + E+ K+ L E K E+ S L++ ++ L
Sbjct: 711 VETLKMEKGEI--EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLN 768
Query: 638 KPRDSRAPLRVQKNVRDNSKD-SEYWQALTTVIPSSKQNLWDALYTALEKYHLVLTQRAK 696
+ +D ++KN+ D E L++ + KQ L E + L +R+
Sbjct: 769 QKKDMEI-AELKKNIEQMDTDHKETKDVLSSSLEEQKQ--LTQLINKKEIFIEKLKERSS 825
Query: 697 LLLENSSLEQQNTELQALLQQYLNSKINS 725
L E Q +L+Q + K S
Sbjct: 826 KLQEELDKYSQALRKNEILRQTIEEKDRS 854
Score = 62.4 bits (150), Expect = 1e-09
Identities = 148/734 (20%), Positives = 295/734 (40%), Gaps = 126/734 (17%)
Query: 74 KQKEESRLK-LAKLLLCGTELVTNIQVA-IDIREIHRRVEEEEIKRQRIEKLENEVKTSQ 131
KQK E +++ L L E +IQ ++++E H R EEE+ R R E +++ + S
Sbjct: 578 KQKLEDKVENLVDQLNKSQESNVSIQKENLELKE-HIRQNEEELSRIRNELMQSLNQDSN 636
Query: 132 DKFDEITSKWEEGKQKRIPQELWEM---------------LNTQQLHCAGLLEDKNKLIS 176
F + K E + + + Q L E+ + ++L A ED +
Sbjct: 637 SNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLA--CEDVRHQLE 694
Query: 177 EL---QQELKTKDDQYVKDLKKQSDDI----CLLLERMEEQVKNVMKTFREELYNIEK-- 227
E +L + + V+ LK + +I C +R+ E+ KT EEL N
Sbjct: 695 ECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTI-EELSNARNLN 753
Query: 228 --AFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDY-------EKQL----N 274
A ++E + L+ N+KK + A K +E ++ K+ +D +KQL N
Sbjct: 754 TSALQLEHEHLIKLNQKKDMEI--AELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLIN 811
Query: 275 RQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRD----EES 330
++ I+ E+ KL++++ Q L++ + + Q +EK + +L +K+ + EE
Sbjct: 812 KKEIF-IEKLKERSSKLQEELDKYSQALRKNEILRQTIEEK-DRSLGSMKEENNHLQEEL 869
Query: 331 TVIKSQQKR------------------KINRLHDILNNLRSKYAKQIKQFQEENQSLTSD 372
++ +Q R ++++L+ I +L + K +++NQS
Sbjct: 870 ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQS---- 925
Query: 373 YKRLVMQFKELQKAMRHFALIDDE---KFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLG 429
+L+ +E +K M F ++ +++L +EE K L + +H
Sbjct: 926 KMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQD 985
Query: 430 LPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISE 489
+ D + V ++ + + L ++E E + E E + L + +
Sbjct: 986 IQTDNSDIFQETKVQSLNIENGSE-----KHDLSKAETERLVKGIKERELEIKLLNEKNI 1040
Query: 490 KTTKRILMLLCDESGFLIE-------------------SKLLSLLLPLEQNECYLLRLDA 530
TK+I L DE G L + S ++ +Q + Y + +
Sbjct: 1041 SLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREK 1100
Query: 531 IFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAE 590
+F+ L ++ + N LK H++ + I +A++ K E + E +
Sbjct: 1101 VFAVLNEKTRE------NSHLKTEYHKM---MDIVAAKEAALIKLQDENKKLSTRFESSG 1151
Query: 591 QTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKILEAFVMGLK----KPRDSRAPL 646
Q +M E ++L +E++ E +L +L+ G + L
Sbjct: 1152 Q-DMFRETIQNLSRIIREKDIEIDALSQKC--QTLLAVLQTSSTGNEAGGVNSNQFEELL 1208
Query: 647 RVQKNVRDNSKDSEYW--QALTTVIPSSKQNLWDALYTALEKYHLVLTQRAKLLLENSSL 704
+ + ++ K E W Q +TTV QN+ E+ H + +A++L+++ +
Sbjct: 1209 QERDKLKQQVKKMEEWKQQVMTTV-----QNMQHESAQLQEELHQL---QAQVLVDSDNN 1260
Query: 705 EQQNTELQALLQQY 718
+ + L+Q Y
Sbjct: 1261 SKLQVDYTGLIQSY 1274
Score = 49.7 bits (117), Expect = 1e-05
Identities = 131/633 (20%), Positives = 250/633 (39%), Gaps = 115/633 (18%)
Query: 66 EEDQSKSYKQKEESRLKLAKL--------------LLCGTELVT-NIQVAIDIREIHRRV 110
E+++S ++KEE ++ L KL + +EL + + +E+++ +
Sbjct: 428 EKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSI 487
Query: 111 EEEEIKRQRIEKLENEVKTSQDKF----DEITSKWEEGKQKRIPQELWEMLNTQQLHCAG 166
E+E IE+L+ + + + D+++ + EG I +L + LN ++
Sbjct: 488 SEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDS--IISKLKQDLNDEKKRVHQ 545
Query: 167 LLEDKNKLISEL--------------------QQELKTKDDQYVKDLKK-QSDDICLLLE 205
L +DK + EL +Q+L+ K + V L K Q ++ + E
Sbjct: 546 LEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKE 605
Query: 206 RMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKW---EQALQAHNAK----ELEY 258
+E +K ++ EEL I + SN K E+ + N K ELE
Sbjct: 606 NLE--LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQ 663
Query: 259 LNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQ-QLQQRKAIYQLNQEK-- 315
LN +KKV K N + + CE+ ++ +LE+ + Q L++ + L EK
Sbjct: 664 LNENLKKVAFDVKMENEKLVLACED---VRHQLEECLAGNNQLSLEKNTIVETLKMEKGE 720
Query: 316 LEYNLQVLKKR------DEESTVIKSQQKRKINRL-----HDILNNLRSKYAKQIKQFQE 364
+E L KKR E T+ + R +N H+ L L K +I + ++
Sbjct: 721 IEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780
Query: 365 ENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAK-----DLIARAFDV 419
+ + +D+K + + + ++K I + E +K D ++A
Sbjct: 781 NIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840
Query: 420 DRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEA-AAEP- 477
+ I+ S K ++E L R EE++ A A+P
Sbjct: 841 NEILRQ--------------TIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPK 886
Query: 478 --ESYLDLPKQISE-KTTKRILMLLCDESGFLIESK---LLSLLLPLEQNECYL------ 525
+S +L ++S+ T K L +IE + + LL L++ + +
Sbjct: 887 TLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQ 946
Query: 526 -LRLDAIFSALGIESEDDLYKLVNFF--LKYRAHRLSSSLQIKPC---SQASMEKASMEE 579
+++A + L +E ++++ L +K + H +Q + ++ ++E
Sbjct: 947 HEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIEN 1006
Query: 580 TSTRSELELAEQTEMEGEKEESLVEGEKEEEEE 612
S + +L AE E LV+G KE E E
Sbjct: 1007 GSEKHDLSKAE--------TERLVKGIKERELE 1031
Score = 40.4 bits (93), Expect = 0.006
Identities = 90/448 (20%), Positives = 176/448 (39%), Gaps = 75/448 (16%)
Query: 4 PGSLEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRR--EALGEYLDG 61
P S E L + E LS + ++ +Q + I E R +++ +
Sbjct: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383
Query: 62 KKESEEDQSKSYKQKEESRLKLAKLLLCGTELVT--NIQVAIDIREIHRRVEEEEIKRQR 119
+++ E KQ +E + L KLL L+ + Q+ +V E E+ RQ
Sbjct: 1384 ERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQA 1443
Query: 120 IEKLENEVKTSQDKFDEITSKWEE------GKQKRIPQELWE-------MLNTQQLHCAG 166
+ L+ + + ++ + E+ GK+ Q L E ML ++ C
Sbjct: 1444 VTNLKERILILEMDIGKLKGENEKIVETYRGKETEY-QALQETNMKFSMMLREKEFECHS 1502
Query: 167 LLEDK---NKLISELQQELKTKDDQYVKDLK----------KQSDDICLLLERMEEQ--- 210
+ E +L+ E +Q + +Q + +K ++ D + L L++ + +
Sbjct: 1503 MKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTA 1562
Query: 211 VKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAK------------ELEY 258
++N ++ R++ + + E R LL S +AL A + + +L
Sbjct: 1563 LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVS 1622
Query: 259 LNNRMK--------KVEDYEKQLN---RQRIWDC-------EEYNMIKIKLEQDVQILEQ 300
+N M+ +VE ++QLN +QR E+ + L +LE
Sbjct: 1623 SSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEH 1682
Query: 301 QLQQRKAIYQLNQEKLEYNLQVLKKRDE--ESTVIKSQQ--------KRKINRLHDILNN 350
Q+ KA+Y EK + + KK E E VI Q+ +RL + L +
Sbjct: 1683 FQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQL-D 1741
Query: 351 LRSKYAKQIKQFQEENQSLTSDYKRLVM 378
++ + +++K+ E Q + D ++ +M
Sbjct: 1742 VKEEQIEELKRQNELRQEMLDDVQKKLM 1769
Score = 36.2 bits (82), Expect = 0.11
Identities = 61/319 (19%), Positives = 130/319 (40%), Gaps = 25/319 (7%)
Query: 105 EIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHC 164
E H+ ++ K + KL++E K +F+ S ++ ++ I Q L ++ + +
Sbjct: 1118 EYHKMMDIVAAKEAALIKLQDENKKLSTRFE---SSGQDMFRETI-QNLSRIIREKDIEI 1173
Query: 165 AGLLEDKNKLISELQ-----QELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFR 219
L + L++ LQ E + ++L ++ D + +++MEE + VM T +
Sbjct: 1174 DALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQ 1233
Query: 220 ----EELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNR 275
E E+ +++ Q L+ S+ Q + E ++K Q+
Sbjct: 1234 NMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQH 1293
Query: 276 QRIWDCEEYNMIKIKLEQDVQILEQQL--------QQRKAIYQLNQEKLEYNLQVLKKRD 327
C +++ KL+ I+ QL Q + + E L + ++L++
Sbjct: 1294 SIGQLCNTKDLLLGKLD----IISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQEL 1349
Query: 328 EESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAM 387
EE ++ I L + + L A + ++E++ S+ K+L + LQK +
Sbjct: 1350 EELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLL 1409
Query: 388 RHFALIDDEKFWEIWLMNE 406
+ L+ K ++ NE
Sbjct: 1410 KEKDLLIKAKSDQLLSSNE 1428
Score = 34.3 bits (77), Expect = 0.43
Identities = 30/178 (16%), Positives = 87/178 (48%), Gaps = 11/178 (6%)
Query: 221 ELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLN------ 274
+L NI K + R + + ++ + AH K E +++ DYE+++
Sbjct: 213 KLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLL 272
Query: 275 RQRIWDCEEYNMIKI-KLEQDVQILE-QQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTV 332
+Q E ++ KI ++++ +Q+L+ ++++ K + QL + + N ++ ++ +
Sbjct: 273 QQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDIL 332
Query: 333 IKSQQKRKINR--LHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMR 388
+ Q++ + + + + NL+ + +K +++ ++T + +R++ Q +++ R
Sbjct: 333 RREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMT-EKERILAQSASVEEVFR 389
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 66.2 bits (160), Expect = 1e-10
Identities = 82/411 (19%), Positives = 189/411 (45%), Gaps = 55/411 (13%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
Q+++QA + L++ + L + E E ++ +Q+EE + + + E
Sbjct: 321 QQQLQAEADHLGKELQS-----VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE 375
Query: 93 LVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWE-EGKQKRIPQ 151
+ + I +E R +EE+++RQ E E K + + WE E K +R +
Sbjct: 376 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE----EMMWEKEEKMRRQEE 431
Query: 152 ELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQV 211
+WE ++ L E ++ +QE K ++++ +++ +K+ + + R EE++
Sbjct: 432 MMWE----KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW-RQEEKI 486
Query: 212 KNVMKTFREE----------LYNIEKAFEVER----------QELLASNKKKWEQALQAH 251
+ + RE+ ++ EK E E+ +E + ++ W Q + H
Sbjct: 487 REQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIH 546
Query: 252 N-----AKELEYLNNRMKKVEDYEKQLNRQ--RIWDCEEYNMIKIKLEQDVQILEQQ--L 302
K+ E + + +K+ D E+++ Q ++W EE KI+ EQ+ +I EQ+ +
Sbjct: 547 EQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEE----KIR-EQEEKIREQEEKI 601
Query: 303 QQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLR---SKYAKQI 359
++++ + Q +EK+ + + +++E+ + + +R+ ++ + +R K +Q
Sbjct: 602 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 661
Query: 360 KQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFW--EIWLMNEEE 408
+ QE+ + + +++ Q +++Q+ +EK W E+ L +EE
Sbjct: 662 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR-QEEKMWEQEVRLRQQEE 711
Score = 55.1 bits (131), Expect = 2e-07
Identities = 74/355 (20%), Positives = 164/355 (46%), Gaps = 38/355 (10%)
Query: 76 KEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFD 135
KE++ KL L +E ++ ++++E+ R++E ++ + ++L+ E +
Sbjct: 281 KEKNAKLQEKLQLVESE---KSEIQLNVKELKRKLERAKLLLPQ-QQLQAEADHLGKELQ 336
Query: 136 EITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKK 195
+++K + ++ ELW LN QQ E+K + E QE + K + + +++
Sbjct: 337 SVSAKLQAQVEEN---ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIRE 393
Query: 196 QSDDICLLLERMEEQV-KNVMKTFREELYNIEKAFEVERQELLASNKKK-----WEQALQ 249
Q + + R EE + + K R+E EK ++ RQE + K++ E+ +
Sbjct: 394 QEEK----MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 449
Query: 250 AHNAKELEYLNNRMKKVEDYEKQLNRQ-RIWDCEEYNMIKIKLEQDVQILEQQ---LQQR 305
+E E +K+ + EK+ ++ ++W EE KI+ EQ+ +I EQ+ +Q
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE----KIR-EQEEKIREQEEKMWRQE 504
Query: 306 KAIYQLNQEKLEYNLQVLKKRDEESTVIKSQ-----QKRKINRLHDILNNLRSKYAKQIK 360
+ I++ + + E Q ++ + I+ Q QK KI+ + + K +Q +
Sbjct: 505 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEE 564
Query: 361 QFQEENQSLTSDYKRLVMQ---FKELQKAMRHFALIDDEKFWEIWLMNEEEAKDL 412
+ ++ + + +++ Q +E ++ +R +EK E M +E+ + +
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIRE----QEEKIREQEEMTQEQEEKM 615
Score = 53.5 bits (127), Expect = 7e-07
Identities = 62/332 (18%), Positives = 155/332 (46%), Gaps = 38/332 (11%)
Query: 40 RLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQV 99
++R + + E + E + E E+ + + K++EE +++ + + +
Sbjct: 425 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 484
Query: 100 AIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNT 159
I +E R +EE++ RQ + E E ++K E W + ++ R +E+W
Sbjct: 485 KIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWR---- 540
Query: 160 QQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFR 219
+ + I E +++++ ++++ + +K D E++ EQ + K +R
Sbjct: 541 -----------QKEKIHEQEEKIRKQEEKMWRQEEKMHDQ----EEKIREQEE---KVWR 582
Query: 220 EELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIW 279
+E E+ ++ QE +++ Q + ++ E + + +K+++ E+++ RQ
Sbjct: 583 QEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQ--- 639
Query: 280 DCEEYNMIKIKLEQDVQILEQQ--LQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQ 337
EE KI+ EQ+ +I EQ+ +++++ + Q +EK+ + + +++E+ +Q
Sbjct: 640 --EE----KIR-EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK----MQEQ 688
Query: 338 KRKINRLHDILNNLRSKYAKQIKQFQEENQSL 369
+ K+ R + + + +Q ++ QE + L
Sbjct: 689 EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720
Score = 40.8 bits (94), Expect = 0.005
Identities = 65/305 (21%), Positives = 115/305 (37%), Gaps = 60/305 (19%)
Query: 107 HRRVEEEEIKRQRIEKLENEVKTSQDKFDEIT-SKWEEGKQKRIPQELWEMLNTQQLHCA 165
H +E++ Q E L E++ +T K E Q + L +
Sbjct: 166 HSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 225
Query: 166 GLLEDKNKLISELQQEL------KTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFR 219
L D K EL+Q L K K D+Y+++L K+ D + L L R T
Sbjct: 226 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYR---------NTIT 276
Query: 220 EELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIW 279
+E + A E+ +L+ S K + + N KEL
Sbjct: 277 DEELKEKNAKLQEKLQLVESEKSEIQL-----NVKEL----------------------- 308
Query: 280 DCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQ-EKLEYNLQVLKKRDEESTVIKSQQK 338
K KLE+ +L QQ Q +A + + + + LQ + +E + QQ+
Sbjct: 309 --------KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE 360
Query: 339 RKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFK---ELQKAMRHFALIDD 395
K+ R + + K +Q ++ +E+ + + +++ Q + E ++ MR +
Sbjct: 361 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR----QE 416
Query: 396 EKFWE 400
E WE
Sbjct: 417 EMMWE 421
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 66.2 bits (160), Expect = 1e-10
Identities = 84/373 (22%), Positives = 178/373 (47%), Gaps = 30/373 (8%)
Query: 48 EARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIH 107
E R+RE + + K + EE Q + Q+EE +L+ + E Q +R
Sbjct: 245 EWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ 304
Query: 108 --RRVEEEEIKRQRIEKLENEVKTSQD---KFDEITSKWEEGKQKRIPQELWEMLNTQQL 162
RR +EEE + Q+ E+ E + + Q + ++ + EE +++++ +E E QQL
Sbjct: 305 QLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQL 364
Query: 163 HCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREEL 222
+++ + +L++E + + +Q ++ ++ + L R E+Q++ + RE+
Sbjct: 365 RRE---QEEERREQQLRREQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQQ 418
Query: 223 YNIEKAFEVERQELLASNK---KKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRI- 278
E+ E++E K ++ EQ L+ + ++L R ++ E +E++ +Q++
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWL-KREEETERHEQERRKQQLK 477
Query: 279 WDCEEYNMIK-IKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQ 337
D EE + +KLE++ E++ QQ + QL +E+ E Q LK+++EE + QQ
Sbjct: 478 RDQEEERRERWLKLEEE----ERREQQERREQQLRREQEERREQRLKRQEEEE---RLQQ 530
Query: 338 KRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEK 397
+ + + LR + ++ +Q + + + +R + K Q+ R L +E+
Sbjct: 531 RLRSEQ------QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 398 FWEIWLMNEEEAK 410
+ L E+E +
Sbjct: 585 RRQQRLKREQEER 597
Score = 62.8 bits (151), Expect = 1e-09
Identities = 124/588 (21%), Positives = 232/588 (39%), Gaps = 109/588 (18%)
Query: 60 DGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQR 119
D + E E Q + K++E+ R L E + Q ++ R+ RR +EE+ RQR
Sbjct: 126 DRQLEEEPGQRRRQKRQEQERE------LAEGEEQSEKQERLEQRDRQRR--DEELWRQR 177
Query: 120 IEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQ 179
E E E + ++ EE Q E E + +QL LLE + K E Q
Sbjct: 178 QEWQEREERRAE----------EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ 227
Query: 180 QELKTKDDQYV-----KDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQ 234
Q+ + + D+ K+ +K+ + E+++E+ + +EE + K +ERQ
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK---LERQ 284
Query: 235 ELLASNKKKWEQALQAHNAKEL----------------EYLNNRMKKVEDYEKQLNRQ-- 276
EL +++ +Q + ++L E R ++ E E+QL R+
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Query: 277 -------RIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEE 329
R EE +++ EQ+ + EQQL++ + + + Q + E L+ ++ E
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 330 STVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQ-SLTSDYKRLVMQFKELQKAMR 388
+ + QQ R+ +L + +Q+++ QEE + + +R + K Q+ R
Sbjct: 405 QQLRREQQLRREQQL---------RREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 389 HFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQ 448
+ ++E +E K + R + +R + W + +
Sbjct: 456 DWLKREEETERH----EQERRKQQLKRDQEEER-------------RERWL-----KLEE 493
Query: 449 QPQKSATQIVEEMLMRSEEEEAEEAAAEPE------SYLDLPKQISEKTTKRILMLLCDE 502
+ ++ + E+ L R +EE E+ E L +Q+ + +R LL E
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 503 SGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSL 562
+E + L EQ E D L K + R RL
Sbjct: 554 EEKRLEQERREQRLKREQE----------------ERRDQLLKREE---ERRQQRLKREQ 594
Query: 563 QIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEE 610
+ + + E+ E R E L ++ E E E+ + L++ E++EE
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRL-KREEPEEERRQQLLKSEEQEE 641
Score = 59.7 bits (143), Expect = 1e-08
Identities = 83/353 (23%), Positives = 159/353 (45%), Gaps = 38/353 (10%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
QER + + LR R R E L G+K EE+Q +++E LK + L C
Sbjct: 1346 QER-EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404
Query: 93 LVTNIQVAIDIREIHRRVEEEEIKRQ------RIEKLENEVKTSQDKF--DEITSKWEEG 144
Q+ D R+ R EE+++ RQ R E+ + + + KF +E + E
Sbjct: 1405 ---EQQLRQD-RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 145 KQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLL 204
++ R ++L + QQLH E K + E QQ + + D+ ++ + +S +
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQ---ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517
Query: 205 ERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMK 264
E+Q+ + ++ F E Q+L ++ E+ Q ++ ++
Sbjct: 1518 LEEEQQLHRQQR---------QRKFLQEEQQL-----RRQERGQQRRQDRDRKFREEEQL 1563
Query: 265 KVEDYEKQLNRQ---RIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQE---KLEY 318
+ E E+QL+RQ R + EE + + + E+ EQQL++++ QL QE K
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Query: 319 NLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAK--QIKQFQEENQSL 369
+ Q+L++R+E+ + + ++ + + R + + + ++F+EE Q L
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLL 1676
Score = 57.8 bits (138), Expect = 4e-08
Identities = 77/386 (19%), Positives = 171/386 (44%), Gaps = 51/386 (13%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
QE+++ + + E +RE + +K ++Q + Y+++E+ + + +LL
Sbjct: 896 QEQLRKEQQLLQEEEEELQRE------EREKRRRQEQERQYREEEQLQQEEEQLL----- 944
Query: 93 LVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQE 152
R E E+ +RQ E+ + K Q K +++ E +KR QE
Sbjct: 945 ----------------REEREKRRRQERERQYRKDKKLQQKEEQLLG---EEPEKRRRQE 985
Query: 153 LWEMLNTQQLHCAGLLEDKNKLISELQQELKTKD--DQYVKDLKKQSDDICLLLERMEEQ 210
+ ++ L +++ +L+ E +++ + ++ QY K + Q ++ LL E E++
Sbjct: 986 REKKYREEE----ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 211 VKNVMKTFREELYNIEKAFEVERQELLASNKK-KWEQALQAHNAKELEYLNNRMKKV-ED 268
RE Y E+ + E ++LL ++ + Q L+ KE E + + E+
Sbjct: 1042 RLQE----RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Query: 269 YEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQE-KLEYNLQVLKKRD 327
EK+ ++R C E E+++Q E+QL + + + QE + +Y + +++
Sbjct: 1098 PEKRRRQERERQCRE--------EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE 1149
Query: 328 EESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAM 387
EE + + +KR+ L ++ + +EE + + +R + +ELQ+
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQK 1209
Query: 388 RHFALIDDEKFWEIWLMNEEEAKDLI 413
R D+++ ++ E E ++ +
Sbjct: 1210 RKQRYRDEDQRSDLKWQWEPEKENAV 1235
Score = 57.4 bits (137), Expect = 5e-08
Identities = 145/703 (20%), Positives = 277/703 (39%), Gaps = 103/703 (14%)
Query: 37 QARRLRIAARLEARRREALG----EYLDGKKESEEDQSKSYKQKEESRLKLAK------- 85
+ RR ++ R E RR++ L E L+ + + EE + +++ E RLK +
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 86 LLLCGTELVTNIQVAIDIREIHRRV------EEEEIKRQRIEKLENEVKTSQDKFDEITS 139
LL E Q + + RR EEEE QR+++ E + Q+ +E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 140 KWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISE-LQQELKTKDDQYVKDLKKQSD 198
+ E + RIP+ W++ + + + K + +QE + K + +L+ Q +
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 199 DICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEY 258
+ ++ EEQ ++ ++ E EK+ E RQ L A + EQ + A+E +
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAE----EKS-ERGRQRLSARPPLR-EQRERQLRAEERQQ 805
Query: 259 LNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQIL--EQQLQQRKAIYQLNQEKL 316
R E+ ++Q RQR + E+++Q L E+QLQ+R+ QL +E+
Sbjct: 806 REQRFLPEEEEKEQRRRQR-----------REREKELQFLEEEEQLQRRERAQQLQEEED 854
Query: 317 EYNLQVLKKRDEEST-------VIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSL 369
++R +E ++ ++KR+ + L+ L+ + K+ + QEE + L
Sbjct: 855 GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY-AKPALQEQLRKEQQLLQEEEEEL 913
Query: 370 TSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLG 429
+ +R + +E ++ R + E+ + E+ + R + D+ +
Sbjct: 914 QRE-EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972
Query: 430 LPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISE 489
L + ++P+K Q E+ EE + EE E +Q E
Sbjct: 973 L---------------LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 490 KTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNF 549
+ ++ DE L+Q E LLR E + +L
Sbjct: 1018 RQYRK-----KDE---------------LQQEEEQLLR-----------EEREKRRLQE- 1045
Query: 550 FLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEE 609
+ R +R LQ + E+ ET R ELE + E E ++EE + E+ E
Sbjct: 1046 --RERQYREEEELQQEEEQLLGEER----ETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Query: 610 EEETPPSPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVI 669
+ + L+ E + L++ R+ R +++ R+ + + + L
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQL--LREEREKRRRQELERQYREEEEVQQEEEQLLREE 1157
Query: 670 PSSKQNLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQ 712
P ++ L + + + +LL E +Q E Q
Sbjct: 1158 PEKRRR--QELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198
Score = 54.3 bits (129), Expect = 4e-07
Identities = 72/349 (20%), Positives = 161/349 (46%), Gaps = 53/349 (15%)
Query: 21 QILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESR 80
Q+L QER R+ R +L+ + + LGE + +K +++ K Y+++EE +
Sbjct: 942 QLLREEREKRRRQER--ERQYRKDKKLQQKEEQLLGE--EPEKRRRQEREKKYREEEELQ 997
Query: 81 LKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSK 140
+ +LL R E E+ +RQ E+ + Q + +++
Sbjct: 998 QEEEQLL---------------------REEREKRRRQEWERQYRKKDELQQEEEQLLR- 1035
Query: 141 WEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKD--DQYVKDLKKQSD 198
EE +++R+ + + ++L +++ +L+ E ++ + ++ QY K+ + Q +
Sbjct: 1036 -EEREKRRLQERERQYREEEELQ-----QEEEQLLGEERETRRRQELERQYRKEEELQQE 1089
Query: 199 DICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEY 258
+ LL E E++ + RE E+ + E ++LL ++K +ELE
Sbjct: 1090 EEQLLREEPEKRRRQE----RERQCREEEELQQEEEQLLREEREK-------RRRQELER 1138
Query: 259 LNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEY 318
++V+ E+QL R+ E + +LE+ + E++LQQ + QL +E+ E
Sbjct: 1139 QYREEEEVQQEEEQLLRE-----EPEKRRRQELERQYR-EEEELQQEEE--QLLREEQEK 1190
Query: 319 NLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQ 367
Q +++ E ++ Q++++ R D ++L+ ++ + + +N+
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239
Score = 53.9 bits (128), Expect = 5e-07
Identities = 83/399 (20%), Positives = 177/399 (44%), Gaps = 44/399 (11%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
+E+ Q RR R R RE ++L+ +++ + + Q+EE L+ + E
Sbjct: 815 EEKEQRRRQR-------REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE 867
Query: 93 LVTNIQVAIDIREIHRRVEEEEIKRQRI-EKLENEVKTSQDKFDEITSKWEEGKQKRIPQ 151
+ + + E +R + + E+L E + Q++ +E+ EE +++R +
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR--EEREKRRRQE 925
Query: 152 ELWEMLNTQQLHCAGLLEDKNKLISELQQELKT--KDDQYVKDLKKQSDDICLLLERMEE 209
+ + +QL +++ +L+ E +++ + ++ QY KD K Q + LL E E+
Sbjct: 926 QERQYREEEQLQ-----QEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 210 QVKNVMKTFREELYNIEKAFEVERQELLASNKKK-----WEQALQAHNA--KELEYL--- 259
+ + RE+ Y E+ + E ++LL ++K WE+ + + +E E L
Sbjct: 981 RRRQE----REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 260 NNRMKKVEDYEKQLNRQRIWDCEEYNMI--------KIKLEQDVQILEQQLQQRKAIYQL 311
+++++ E+Q + EE ++ + +LE+ + E+ Q+ + + +
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 312 NQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTS 371
EK + + R+EE + +Q + R L +Y ++ + QEE Q L
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 372 DYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAK 410
+ ++ Q EL++ R + E E L+ EE+ K
Sbjct: 1157 EPEKRRRQ--ELERQYREEEELQQE---EEQLLREEQEK 1190
Score = 53.1 bits (126), Expect = 9e-07
Identities = 79/400 (19%), Positives = 169/400 (42%), Gaps = 44/400 (11%)
Query: 48 EARRREALGEYLDGKKESEEDQSKSYKQKEESRLK--LAKLLLCGTELVTNIQVAIDIRE 105
E RRR+ L ++E ++++ + +++ E R + L + EL + + +
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Query: 106 IHRRVE-------EEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRI--------- 149
RR E EEE++RQ+ ++ + +D+ ++ +WE K+ +
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRD----EDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 150 -PQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKD-------DQYVKD---LKKQSD 198
E + L QL +D L+ E Q+ + ++ D++ + L+++
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 199 DICLLLERMEEQVKNVMKTFREEL---YNIEKAFEVERQELLASNKKKWEQALQAHNAKE 255
+R ++ K +++ REE ++ F E Q L ++ + + +E
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364
Query: 256 LEYLNNRM-KKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQ-RKAIYQLNQ 313
E + +K + E++L RQ E +K + + Q EQQL+Q R ++ +
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQE----RERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Query: 314 EKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDY 373
++L + K R+EE V + +++RK L R + ++ +Q +E +
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 374 KRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLI 413
+ +F E ++ +R D KF E L ++E + +
Sbjct: 1481 QERDRKFLEEEQQLRRQE--RDRKFREQELRSQEPERKFL 1518
Score = 52.0 bits (123), Expect = 2e-06
Identities = 69/365 (18%), Positives = 162/365 (44%), Gaps = 37/365 (10%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
QER + + R +L + E + L ++E E + + +++EE R +
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE---------- 374
Query: 93 LVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQE 152
++ +R + E++++R++ + E +++ Q E + E+ ++ +E
Sbjct: 375 --QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 153 LWEMLNTQQLHCAGLLEDKNKLISELQQELKT-------KDDQYVKDLKKQSDDICLLLE 205
E + Q+ L ++ + L++E +T + Q +D +++ + L LE
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE 492
Query: 206 ---RMEEQVKNVMKTFREE----LYNIEKAFEVER--------QELLASNKKKWEQALQA 250
R E+Q + + RE+ +++ E ER Q+L +++ EQ L+
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Query: 251 HNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQ 310
K LE R ++++ +++ Q + EE ++K EQ+ + LEQ+L++ +
Sbjct: 553 EEEKRLEQ-ERREQRLKREQEERRDQLLKREEERRQQRLKREQE-ERLEQRLKREEVERL 610
Query: 311 LNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLT 370
+E+ E L+ + +E + ++++ R + + + +++K+ +EE + L
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR-EEEEERLE 669
Query: 371 SDYKR 375
KR
Sbjct: 670 QRLKR 674
Score = 45.8 bits (107), Expect = 1e-04
Identities = 71/389 (18%), Positives = 171/389 (43%), Gaps = 49/389 (12%)
Query: 48 EARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIH 107
+ RR+E ++L+ +++ +++ + ++++E+ + + L E + + + +++
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE--RDRKFLEEEQQLR 1495
Query: 108 RRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGL 167
R+ + + + Q + E E K +++ ++ + + K + Q+L QQ
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEE-QQLHRQQRQRKFLQEEQQLRRQERGQQRR---- 1550
Query: 168 LEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEK 227
+D+++ E +Q + +++Q L +Q D LE + + + + F E+ + +
Sbjct: 1551 -QDRDRKFREEEQLRQEREEQ---QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606
Query: 228 AFEVERQELLASNKKKW---EQALQAHNAKELEYLNNRMKKVEDYEKQLNRQR------- 277
+ +Q+L +K+ EQ LQ ++L + R +K + E QL RQ
Sbjct: 1607 --QEGQQQLRQERDRKFREDEQLLQEREEQQL-HRQERDRKFLEEEPQLRRQEREQQLRH 1663
Query: 278 ------------IWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKK 325
+ + EE + + + ++ + EQQL++++ + QE+ + Q L++
Sbjct: 1664 DRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER 1723
Query: 326 RDEESTVIK----SQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFK 381
+ E ++ +Q R+ R IL +Q++ +EE Q + R + +
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEE------EQLRPEREEQQLRRQERDRKFREEE 1777
Query: 382 ELQKAMRHFAL---IDDEKFWEIWLMNEE 407
+L++ L D KF E + +E
Sbjct: 1778 QLRQEREEQQLRSQESDRKFREEEQLRQE 1806
Score = 40.0 bits (92), Expect = 0.008
Identities = 61/319 (19%), Positives = 154/319 (48%), Gaps = 25/319 (7%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKE-SEEDQSKSYKQKEESRLKLAKLLLCGT 91
QER + RL + RR+E ++++ +++ ++ + +Q+ + + + + LL
Sbjct: 1575 QERDRKFRLE---EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631
Query: 92 ELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQD-KFDEITSKWEEGKQKRIP 150
E + + +E R+ EEE + +R E+ E +++ +D KF E +EG+++++
Sbjct: 1632 E-----EQQLHRQERDRKFLEEEPQLRRQER-EQQLRHDRDRKFREEEQLLQEGEEQQLR 1685
Query: 151 QELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQ 210
++ + ++ E + K + E +Q+L+ ++ + +K ++ L E +EQ
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQE-EQQLRRQELE-----RKFREEEQLRQETEQEQ 1739
Query: 211 VKNVMKTFREELYNIEKAFEVERQELLASNK-KKWEQALQAHNAKELEYLNN-----RMK 264
++ + +R+ L + E E Q+L + +K+ + Q +E + L + + +
Sbjct: 1740 LRR-QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798
Query: 265 KVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLK 324
+ E ++ Q++ + + + EQ +Q+ EQ+ + R+ + + + ++ Q
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQ-LQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857
Query: 325 KRDEESTVIKSQQKRKINR 343
+R+E+ + +QKR+ R
Sbjct: 1858 RREEQELWQEEEQKRRQER 1876
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 65.5 bits (158), Expect = 2e-10
Identities = 92/423 (21%), Positives = 185/423 (43%), Gaps = 80/423 (18%)
Query: 50 RRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLL--------LCGTELVTNIQVAI 101
R +EAL + +KE EE ++K + +L++ C + IQ+
Sbjct: 858 RLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEA 917
Query: 102 DIREIHRRVEEEE-------IKRQRIEKLENEVKTSQDKFDEITSKWE------EGKQKR 148
++E++ R+E+EE K++++E +E+K D + +K E E K K
Sbjct: 918 KVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKN 977
Query: 149 IPQE---LWEMLNTQQLHCAGLLEDKNKLISELQQE---------LKTKDDQYVKDLK-- 194
+ +E L E++ L E + + +LQ E K K +Q V DL+
Sbjct: 978 LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGS 1037
Query: 195 -KQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKK---------- 243
+Q + + LER + +++ +K +E + ++E ++Q+L KKK
Sbjct: 1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN----DKQQLDERLKKKDFELNALNAR 1093
Query: 244 --WEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQ 301
EQAL + K+L+ L R +E+ E++L +R + ++ L ++++ + ++
Sbjct: 1094 IEDEQALGSQLQKKLKELQAR---IEELEEELEAERTARA-KVEKLRSDLSRELEEISER 1149
Query: 302 LQQRKAIYQLNQE---KLEYNLQVLKKRDEESTVIKSQQKRKINRLH-----------DI 347
L++ + E K E Q +++ EE+T+ + + H D
Sbjct: 1150 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1209
Query: 348 LNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEE 407
L ++ K K+ +F+ E +TS+ ++++ L+K R ++D+ MNE
Sbjct: 1210 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCR---TLEDQ-------MNEH 1259
Query: 408 EAK 410
+K
Sbjct: 1260 RSK 1262
Score = 57.4 bits (137), Expect = 5e-08
Identities = 70/304 (23%), Positives = 137/304 (45%), Gaps = 43/304 (14%)
Query: 92 ELVTNIQVAIDIREIHRRVEEEEIKRQRIEK--LENEVKTSQDKFDEITSKWEEGKQKRI 149
E T ++ A++ E R+ EE++ EK L+ +V+ QD + + ++ + +I
Sbjct: 854 EEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI 913
Query: 150 PQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEE 209
L + LED+ ++ +EL + + +D+ +LK+ DD+ L L ++E+
Sbjct: 914 ------QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE-CSELKRDIDDLELTLAKVEK 966
Query: 210 Q---VKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKV 266
+ +N +K EE+ ++ E++A K+ ++ALQ + + L+ L KV
Sbjct: 967 EKHATENKVKNLTEEMAGLD--------EIIAKLTKE-KKALQEAHQQALDDLQAEEDKV 1017
Query: 267 EDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAI---YQLNQEKLEYNLQVL 323
K K+KLEQ V LE L+Q K + + + KLE +L++
Sbjct: 1018 NTLTKA---------------KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLT 1062
Query: 324 KKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKEL 383
++ + K Q ++ + LN L ++ I+ Q L K L + +EL
Sbjct: 1063 QESIMDLENDKQQLDERLKKKDFELNALNAR----IEDEQALGSQLQKKLKELQARIEEL 1118
Query: 384 QKAM 387
++ +
Sbjct: 1119 EEEL 1122
Score = 57.0 bits (136), Expect = 6e-08
Identities = 68/327 (20%), Positives = 141/327 (43%), Gaps = 42/327 (12%)
Query: 45 ARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIR 104
A L+ +A E + + E D + ++ EE++ KLA+ L E V +
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414
Query: 105 E-----IHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNT 159
E + +E+ + +R + Q FD+I ++W KQK +E L +
Sbjct: 1415 EKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW---KQKY--EESQSELES 1469
Query: 160 QQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFR 219
Q L + KL + ++ L ++++ K+++ ++ + + EQ+ + KT
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESL-----EHLETFKRENKNLQEEISDLTEQLGSSGKTI- 1523
Query: 220 EELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIW 279
EL + K E E+ EL + AL+ A +E E ++ R ++
Sbjct: 1524 HELEKVRKQLEAEKMEL--------QSALEEAEA-----------SLEHEEGKILRAQL- 1563
Query: 280 DCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKR 339
E+N IK ++E+ + +++++Q K + + L+ +L + E+ +K + +
Sbjct: 1564 ---EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG 1620
Query: 340 KINRLHDIL---NNLRSKYAKQIKQFQ 363
+N + L N + ++ KQ+K Q
Sbjct: 1621 DLNEMEIQLSHANRMAAEAQKQVKSLQ 1647
Score = 44.7 bits (104), Expect = 3e-04
Identities = 121/595 (20%), Positives = 243/595 (40%), Gaps = 97/595 (16%)
Query: 67 EDQSKSYKQK-EESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLEN 125
EDQ ++ K EE++ + L +L T + E+ R+++E+E I +L
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQT------ENGELSRQLDEKEAL---ISQLTR 1303
Query: 126 EVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGL---LEDKNKLISELQQEL 182
T + +++ + EE + + L L + + C L E++ + +ELQ+ L
Sbjct: 1304 GKLTYTQQLEDLKRQLEE--EVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1361
Query: 183 KTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFRE----------ELYNIEKA---- 228
+ + + K D E +EE K + + +E + ++EK
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRL 1421
Query: 229 --------FEVER---------------QELLASNKKKWE--QALQAHNAKELEYLNNRM 263
+VER ++LA K+K+E Q+ + KE L+ +
Sbjct: 1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481
Query: 264 KKVED-YEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQL-QQRKAIYQLN--QEKLEYN 319
K+++ YE+ L + E N L++++ L +QL K I++L +++LE
Sbjct: 1482 FKLKNAYEESLEHLETFKRENKN-----LQEEISDLTEQLGSSGKTIHELEKVRKQLEAE 1536
Query: 320 LQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQ 379
L+ EE+ ++ KI R N ++++ +++ + EE + ++ R+V
Sbjct: 1537 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS 1596
Query: 380 FK---ELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPD 436
+ + + R+ AL +K +NE E + ++ A + L D
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGD--LNEMEIQ--LSHANRMAAEAQKQVKSLQSLLKD 1652
Query: 437 FWFLNNVGPISQQPQKSATQIVEEM--LMRSEEEEAEEAAAEPESYLDLPKQISEKTTKR 494
+ + K IVE L+++E EE + E L +Q +T++R
Sbjct: 1653 TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER 1712
Query: 495 ILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYR 554
+ +L + + + K ++DA S L E E+ + + N K +
Sbjct: 1713 VQLLHSQNTSLINQKK----------------KMDADLSQLQTEVEEAVQECRNAEEKAK 1756
Query: 555 -----AHRLSSSLQIKPCSQASME--KASMEET--STRSELELAEQTEMEGEKEE 600
A ++ L+ + + A +E K +ME+T + L+ AEQ ++G K++
Sbjct: 1757 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811
Score = 40.0 bits (92), Expect = 0.008
Identities = 70/398 (17%), Positives = 171/398 (42%), Gaps = 52/398 (13%)
Query: 44 AARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDI 103
AA L+ ++R + K++ EE QS+ ++E+R +L +L + +++
Sbjct: 1439 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELF----KLKNAYEESLEH 1494
Query: 104 REIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLH 163
E +R E + ++ I L ++ +S E+ E +K++ E E+ + +
Sbjct: 1495 LETFKR--ENKNLQEEISDLTEQLGSSGKTIHEL-----EKVRKQLEAEKMELQSALEEA 1547
Query: 164 CAGLLEDKNKLI----------SELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKN 213
A L ++ K++ +E++++L KD++ + + + L ++ + ++
Sbjct: 1548 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS 1607
Query: 214 VMKTFREELYNIEKAFEVERQEL---------LASNKKKWEQALQAHNAKELEYLNNRMK 264
R E ++K E + E+ +A+ +K ++LQ+ L++ ++
Sbjct: 1608 -----RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1662
Query: 265 KVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLK 324
+D ++ + N+++ +LE+ ++EQ + RK QE +E + +V
Sbjct: 1663 ANDDLKENIAIVE----RRNNLLQAELEELRAVVEQTERSRKL---AEQELIETSERVQL 1715
Query: 325 KRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQ 384
+ +++I QK+K++ L + ++ + +E+ + +D + + K+ Q
Sbjct: 1716 LHSQNTSLI--NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1773
Query: 385 KAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRI 422
H + E+ KDL R + ++I
Sbjct: 1774 DTSAHLERMKKNM--------EQTIKDLQHRLDEAEQI 1803
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 65.1 bits (157), Expect = 2e-10
Identities = 114/561 (20%), Positives = 237/561 (42%), Gaps = 64/561 (11%)
Query: 92 ELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQ 151
+LVT +A+++ E H ++E +++ I++LE + +T + +T EE Q+ Q
Sbjct: 1551 QLVTLECLALELEENHHKME---CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ 1607
Query: 152 --ELWEMLNTQQLHCAGLLEDKNKLISELQQ--ELKTKDDQYVKDLKKQSDDICLLLER- 206
++ ++ + + L E ++ S+ +Q EL+ + + +DL+++ ++ L ER
Sbjct: 1608 SSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERI 1667
Query: 207 --MEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNA----------- 253
+E+Q K E+L I+ + +EL + E+A +
Sbjct: 1668 QVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHM 1727
Query: 254 --------KELEYLNNRMKKVEDYEKQLNRQRIW---DCEEYNMIKIKLEQDVQILEQQL 302
KE+E + ++++ + QL +Q E +++ + EQ++ +L+QQL
Sbjct: 1728 KLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQL 1787
Query: 303 QQRKAIYQLNQEKLEYNL----QVLKKRDEESTVIKSQQKR------KINRLHDILNNLR 352
Q+ + +L ++ L+ L + L +RD+E ++ +Q++ ++ D L
Sbjct: 1788 QEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGAL 1847
Query: 353 SKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDL 412
+ +K+ E Q +RL +EL R + +E ++ + E+ K L
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLE---EELAVEGRRVQAL-EEVLGDLRAESREQEKAL 1903
Query: 413 IARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEE 472
+A H + A D W L + ++ Q+ E R +EE A
Sbjct: 1904 LALQQQCAEQAQEHEVETR-ALQDSW-LQAQAVLKERDQELEALRAESQSSRHQEEAARA 1961
Query: 473 AAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIF 532
A + L K + K +L E +E+ +L L+ + + +L+
Sbjct: 1962 RAEALQEALG--KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE--- 2016
Query: 533 SALGIESEDDLYKLVNFFLKYR--AHRLSSSLQIKPCSQASMEKASMEETSTRSELELAE 590
AL I+ + + + L+Y+ +L +L +Q E +E E LA+
Sbjct: 2017 EALRIQEGE----IQDQDLRYQEDVQQLQQAL-----AQRDEELRHQQEREQLLEKSLAQ 2067
Query: 591 QTEMEGEKEESLVEGEKEEEE 611
+ + +E+ + E+EEEE
Sbjct: 2068 RVQENMIQEKQNLGQEREEEE 2088
Score = 63.2 bits (152), Expect = 9e-10
Identities = 123/585 (21%), Positives = 244/585 (41%), Gaps = 73/585 (12%)
Query: 43 IAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAID 102
+A LE+ RE + E KE + + Q+EE R + A+ LC +L T +
Sbjct: 873 LAKALESLEREKM-ELEMRLKEQQTEMEAIQAQREEERTQ-AESALCQMQLETEKERVSL 930
Query: 103 IREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQL 162
+ + + +E Q++E+L ++K + K E T + Q+ +EL E +
Sbjct: 931 LETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQE-AQRELKEAARQHRD 989
Query: 163 HCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREEL 222
A L E+ + L+ + + +L+ + + L Q D L+ + ++E+++ +E
Sbjct: 990 DLAALQEESSSLLQD-KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET-----QEY 1043
Query: 223 YNIEKAFEVERQELLASNKKKWEQALQAHNA-----KELEYLNNRMKKVEDYEKQLNRQR 277
I+K E E+ L S +K ++ L A +EL L M++ + +K+L+ Q
Sbjct: 1044 NRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQ- 1102
Query: 278 IWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQ 337
+++L Q++++++A + + +L L+ +++ Q
Sbjct: 1103 -----------------MELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQ 1145
Query: 338 KRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAM------RHFA 391
+ K +L L + S+ + Q NQ+ +L + LQ+A+ R
Sbjct: 1146 EAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ--AQLASLYSALQQALGSVCESRPEL 1203
Query: 392 LIDDEKFWEIWLMNEEE--AKDLIAR--------AFDVDRIIHTHHLGLPWAAPDFWFLN 441
+ +W + ++ A+ L R A V +H H D W
Sbjct: 1204 SGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH-------QDLW--- 1253
Query: 442 NVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCD 501
+QQ + V+++ R + EAE++ E DL +Q+S+ ++
Sbjct: 1254 ----KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTE-LQDLQRQLSQNQEEKSKWEGKQ 1308
Query: 502 ESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSS 561
S +ES+L+ L + + L R A + + E +L + L + L ++
Sbjct: 1309 NS---LESELMELHETMASLQSRLRR--AELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363
Query: 562 LQIKPCSQASMEKASMEETST-RSELELA-EQTEMEGEKEESLVE 604
+ ++ +QAS E+ T RS L+L E+ E E E+ ++L E
Sbjct: 1364 V-VEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQE 1407
Score = 60.8 bits (146), Expect = 4e-09
Identities = 150/721 (20%), Positives = 288/721 (39%), Gaps = 113/721 (15%)
Query: 36 IQARRLRIAAR-LEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELV 94
++AR AA LE R A +E E ++ ++ +E+ LK+A+ G L
Sbjct: 1365 VEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ----GKALQ 1420
Query: 95 TNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQK-RIPQEL 153
N+ A+ + + R EE E R +I++LE + + + + ++ ++ Q+ + QE
Sbjct: 1421 ENL--ALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ 1478
Query: 154 WEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKN 213
+ L C +LE + E +Q+L + +Q +++L+K E +N
Sbjct: 1479 IQELEK----CRSVLEHLPMAVQEREQKLTVQREQ-IRELEKD-----------RETQRN 1522
Query: 214 VMKTFREELYNIEKAFE-VERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQ 272
V++ +L +EK + +E Q + KK L+ A ELE +++M+ + K+
Sbjct: 1523 VLE---HQLLELEKKDQMIESQRGQVQDLKKQLVTLECL-ALELEENHHKMECQQKLIKE 1578
Query: 273 LNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTV 332
L QR + + LE+ Q L+ Q Q I+ L + L++RD+E
Sbjct: 1579 LEGQRETQRVALTHLTLDLEERSQELQAQSSQ---IHDLESHSTVLARE-LQERDQE--- 1631
Query: 333 IKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFAL 392
+KSQ++ QI++ Q + + LT D +R + +EL +
Sbjct: 1632 VKSQRE-------------------QIEELQRQKEHLTQDLER---RDQELMLQKERIQV 1669
Query: 393 IDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQK 452
++D++ + ++ EE+ + + + R + T + A + + P K
Sbjct: 1670 LEDQRTRQTKIL-EEDLEQIKLSLRERGRELTTQRQLMQERAEE----------GKGPSK 1718
Query: 453 SATQIVEEM--LMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESK 510
+ +E M ++R +E+E E +L Q+ ++ L E+ L+ +
Sbjct: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQG--LHRKVGETSLLLSQR 1776
Query: 511 LLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQA 570
+++ Q + R ++S+ D + L R L + Q + +Q
Sbjct: 1777 EQEIVVL--QQQLQEAREQGELKEQSLQSQLDEAQRA---LAQRDQELEALQQEQQQAQG 1831
Query: 571 SMEKASMEETSTRSELELAEQT--EMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKI 628
E+ + + + LE A T E GE ++ + + EEE V +VL
Sbjct: 1832 QEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGD 1891
Query: 629 LEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEY--------WQALTTVIPSSKQNLW--- 677
L A + +A L +Q+ + +++ E W V+ Q L
Sbjct: 1892 LRA-----ESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR 1946
Query: 678 -----------------DALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLN 720
+AL AL K H L + + LLE + L + A LQ L+
Sbjct: 1947 AESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLD 2006
Query: 721 S 721
+
Sbjct: 2007 A 2007
Score = 56.6 bits (135), Expect = 8e-08
Identities = 97/435 (22%), Positives = 199/435 (45%), Gaps = 66/435 (15%)
Query: 14 VDEHLSTQILAPSVHSDNSQ-ERIQARRLRIAARLEARRREALGEYLD------GKKESE 66
++E L T A + ++ + ER +A+ L+ L+ + +AL E L ++E E
Sbjct: 1377 LEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEE 1436
Query: 67 EDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEK---- 122
+ + Q+ E + ++ K L EL++ +D+++ ++ V+ ++ + Q +EK
Sbjct: 1437 VETLRGQIQELEKQREMQKAAL---ELLS-----LDLKKRNQEVDLQQEQIQELEKCRSV 1488
Query: 123 LENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQEL 182
LE+ Q++ ++T + E+ ++ +E + QL LE K+++I + +
Sbjct: 1489 LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL---ELEKKDQMIESQRGQ- 1544
Query: 183 KTKDDQYVKDLKKQSDDI-CLLLE------RMEEQVKNVMK------TFREELYNIEKAF 229
V+DLKKQ + CL LE +ME Q K + + T R L ++
Sbjct: 1545 -------VQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDL 1597
Query: 230 EVERQELLASNKKKWEQALQAHN---AKELEYLNNRMKKVEDYEKQLNRQR--------- 277
E QEL A + + + L++H+ A+EL+ + +K + ++L RQ+
Sbjct: 1598 EERSQELQAQSSQIHD--LESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLER 1655
Query: 278 -----IWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTV 332
+ E +++ + + +ILE+ L+Q K + +L Q++++R EE
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEG-- 1713
Query: 333 IKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFAL 392
K K + L + LR K K+++ QE L +L Q + L + + +L
Sbjct: 1714 -KGPSKAQRGSLEHMKLILRDK-EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSL 1771
Query: 393 IDDEKFWEIWLMNEE 407
+ ++ EI ++ ++
Sbjct: 1772 LLSQREQEIVVLQQQ 1786
Score = 51.6 bits (122), Expect = 3e-06
Identities = 95/501 (18%), Positives = 209/501 (41%), Gaps = 39/501 (7%)
Query: 35 RIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELV 94
+++ + +R+EA + +D E+E+ + +++ +L K G EL
Sbjct: 621 QLEEENQSVCSRMEAAEQARNALQVD-LAEAEKRREALWEKNTHLEAQLQKAEEAGAELQ 679
Query: 95 TNIQVAIDIREIHRRVEEEEIKRQRIE-KLENEVKTSQDKFDEITSKWEEGKQKRIPQEL 153
+++ DI+E E+EEI+++ E + + E T+Q + +K +E R QE
Sbjct: 680 ADLR---DIQE-----EKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK 731
Query: 154 WEMLNTQ---QLHCAGLLEDKNKLISELQQELKTKD--DQYVKDLKKQSDDICLLLERME 208
++ + ++ + D+ L +LQ K+ + + + ++Q+ I + ++E
Sbjct: 732 EALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLE 791
Query: 209 EQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVED 268
Q++ V + +E + + ++E L + + + EQ A A++L K +
Sbjct: 792 VQIQTVTQA-KEVIQGEVRCLKLE----LDTERSQAEQERDAA-ARQLAQAEQEGKTALE 845
Query: 269 YEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDE 328
+K + + E N ++ K E++ +Q+L KA+ L +EK+E ++ LK++
Sbjct: 846 QQKAAHEK------EVNQLREKWEKERSWHQQELA--KALESLEREKMELEMR-LKEQQT 896
Query: 329 ESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMR 388
E I++Q++ + + L ++ + K+ E + Q + L++ M+
Sbjct: 897 EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMK 956
Query: 389 HFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQ 448
L + E + +E ++L A H L + + Q
Sbjct: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQ-----HRDDLAALQEESSSLLQDKMDLQKQ 1011
Query: 449 QPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIE 508
+ + ++ R E+E +E E + Y + K++ + L L+ E L+
Sbjct: 1012 VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVL 1071
Query: 509 SKLLSLLLPLEQNECYLLRLD 529
+ S + Q E LR D
Sbjct: 1072 QEADS----IRQQELSALRQD 1088
Score = 43.1 bits (100), Expect = 0.001
Identities = 80/371 (21%), Positives = 164/371 (44%), Gaps = 46/371 (12%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEES---RLKLAKLLLC 89
+E+ +L A R A+R + L E L +++ + Q + K+K ++ L+ A + L
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQEL-EALQQEQQQAQGQEERVKEKADALQGALEQAHMTL- 1854
Query: 90 GTELVTNIQVAIDIREIHRRVEEE-EIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKR 148
E +Q D +E RR+EEE ++ +R++ LE + + + S+ +E
Sbjct: 1855 -KERHGELQ---DHKEQARRLEEELAVEGRRVQALEEVLGDLRAE-----SREQEKALLA 1905
Query: 149 IPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKD-DQYVKDLKKQSDDICLLLERM 207
+ Q+ E ++ L + S LQ + K+ DQ ++ L+ +S
Sbjct: 1906 LQQQCAEQAQEHEVETRALQD------SWLQAQAVLKERDQELEALRAESQSS----RHQ 1955
Query: 208 EEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVE 267
EE + + +E L A + + Q LL + + ++L+A A L + +
Sbjct: 1956 EEAARARAEALQEALGKAHAALQGKEQHLL--EQAELSRSLEASTAT----LQASLDACQ 2009
Query: 268 DYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRD 327
+ +QL E ++ ++DVQ L+Q L QR + QE+ + + L +R
Sbjct: 2010 AHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV 2069
Query: 328 EESTVIKSQ------QKRKINRLHDILNNLRSKYAK------QIKQFQEEN--QSLTSDY 373
+E+ + + Q ++ +I LH + L+ A+ ++++ Q+ N ++L +
Sbjct: 2070 QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSH 2129
Query: 374 KRLVMQFKELQ 384
K M+ + L+
Sbjct: 2130 KTSPMEEQSLK 2140
Score = 35.4 bits (80), Expect = 0.19
Identities = 51/248 (20%), Positives = 99/248 (39%), Gaps = 38/248 (15%)
Query: 175 ISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQ 234
+ +LQ++L ++ K KQ+ L+E E + R EL +E E E
Sbjct: 1287 LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELL 1346
Query: 235 ELLASNKKKWEQALQA------HNAKELEYLNNRMK------KVEDYEKQLNRQRIWDCE 282
+ N + LQA A L ++ K+++ E + R+R +
Sbjct: 1347 QAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQ 1406
Query: 283 EYNMIKI------------------KLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLK 324
E +K+ + E++V+ L Q+Q+ + ++ + LE LK
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466
Query: 325 KRDEESTVIKSQQKRKINRLHDILNNL-------RSKYAKQIKQFQEENQSLTSDYKRLV 377
KR++E ++ +Q +++ + +L +L K Q +Q +E + + L
Sbjct: 1467 KRNQE-VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLE 1525
Query: 378 MQFKELQK 385
Q EL+K
Sbjct: 1526 HQLLELEK 1533
Score = 33.1 bits (74), Expect = 0.96
Identities = 90/452 (19%), Positives = 171/452 (37%), Gaps = 92/452 (20%)
Query: 20 TQILAPSVHSDNSQERIQARRLRIAARLEARRREA-LGEYLDGKKESEEDQSKSYKQKEE 78
TQ L H + SQE IQ + + E + R L L ++ ED K K E
Sbjct: 253 TQELEKEAH-ERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE 311
Query: 79 SRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEIT 138
+ + L TEL+ + + R +EE++ Q++ K +V + D I
Sbjct: 312 T---VEILETNHTELMEHEA------SLSRNAQEEKLSLQQVIKDITQVMVEEG--DNIA 360
Query: 139 SKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQ-- 196
+ ++ + Q D +K ++ L + + T+ Q V+DL++Q
Sbjct: 361 QGSGHENSLELDSSIFSQFDYQ---------DADKALT-LVRSVLTRRRQAVQDLRQQLA 410
Query: 197 -SDDICLLLERMEEQVKNVMKTFREELYNI----------------------------EK 227
+ LL++ +Q + K R+ L + +K
Sbjct: 411 GCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
Query: 228 AFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMI 287
A E RQ+L ++ W L+ N EL+ + + ++ +++ + + E +
Sbjct: 471 AREELRQQLEVLEQEAWR--LRRVNV-ELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
Query: 288 KIKLE-QDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHD 346
+ LE + + L + + R+A+ + E ++L++ E T ++ ++ I L
Sbjct: 528 LMGLEAKQSESLSELITLREALESSHLEG-----ELLRQEQTEVTAALARAEQSIAELSS 582
Query: 347 ILNNLRSKYA------------------------KQIKQFQEENQSLTS-----DYKRLV 377
N L+++ A +Q+ Q +EENQS+ S + R
Sbjct: 583 SENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNA 642
Query: 378 MQFKELQKAMRHFALIDDEKFWEIWLMNEEEA 409
+Q + R AL + E L EEA
Sbjct: 643 LQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 63.9 bits (154), Expect = 5e-10
Identities = 147/706 (20%), Positives = 286/706 (40%), Gaps = 81/706 (11%)
Query: 45 ARLEARRREALGEYLDGK-KESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDI 103
A+ E + ++ + + L G+ KE ++ S+ +LAKL +EL + D+
Sbjct: 2268 AQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKL---ESELKSLKDQLTDL 2324
Query: 104 REIHRRVEEEEIKRQRI-EKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQL 162
+ +E++ + I + E +++ S+ ++++ + + ++ + L E +N ++
Sbjct: 2325 SNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRE--LTSRLHEEINMKEQ 2382
Query: 163 HCAGLLEDKNKLISELQQELKTKDDQYVKDLK---KQSDDICLLLERMEEQVKNVMKT-- 217
LL K + I EL+ + D+ +K+L+ Q ++ ++LE EE K V KT
Sbjct: 2383 KIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLE--EENKKAVDKTNQ 2440
Query: 218 FREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQR 277
E L I+K E +Q+ + K +LQ N+R + V DY++ R
Sbjct: 2441 LMETLKTIKK--ENIQQKAQLDSFVKSMSSLQ----------NDRDRIVGDYQQLEERHL 2488
Query: 278 IWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVI---K 334
E+ +I+ ++ ++ E+ R + LN E + + ++++ R++ + VI
Sbjct: 2489 SIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKD 2548
Query: 335 SQQKRKINRLHDILNNLRSKYAK---QIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFA 391
SQQK+ + L +KYAK ++K+ +E N+ L + L + ++L K +
Sbjct: 2549 SQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLK 2608
Query: 392 LIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWF------------ 439
+ + ++ + EE L V + H L +++
Sbjct: 2609 VSISQLTRQVTALQEEGTLGLYHAQLKV-KEEEVHRLSALFSSSQKRIAELEEELVCVQK 2667
Query: 440 --LNNVGPISQQPQKSATQIVEEM-LMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRIL 496
VG I + +K + + +MR+E E AEE AE L + + E K +L
Sbjct: 2668 EAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAE------LARDLVEMEQK-LL 2720
Query: 497 MLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAH 556
M+ + G + + + QN E D+L + + LK A
Sbjct: 2721 MVTKENKGLTAQIQSFGRSMSSLQNS----------RDHANEELDELKRKYDASLKELAQ 2770
Query: 557 RLSSSLQIKPCSQASMEKA-SMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPP 615
L + E A SM T S L + + K+E L+ + E+
Sbjct: 2771 LKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSY-- 2828
Query: 616 SPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQN 675
N V +A + L+ RD + R + + + A + P+ Q+
Sbjct: 2829 -------NQVQSFSKA-MASLQNERDHL--WNELEKFRKSEEGKQRSAAQPSTSPAEVQS 2878
Query: 676 LWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTE---LQALLQQY 718
L A+ + +L + L + + Q+ TE L+A LQ+Y
Sbjct: 2879 LKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEY 2924
Score = 59.3 bits (142), Expect = 1e-08
Identities = 75/377 (19%), Positives = 173/377 (45%), Gaps = 43/377 (11%)
Query: 16 EHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQ 75
E L +QIL ++ +QE I + L A+ + + + E+ K++ ++ S ++
Sbjct: 687 ERLKSQILELELNFHKAQE-IYEKNLDEKAKEISNLNQLIEEF----KKNADNNSSAFTA 741
Query: 76 KEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKF- 134
E R +L V + + ++R +++E + +R +L+ E +T+ D
Sbjct: 742 LSEERDQLLSQ-------VKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLL 794
Query: 135 -DEITSKWEEGKQKRIPQE-LWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQY--- 189
++I S E K K + E L L+ QL +++ LI LQ +L+ K+ +
Sbjct: 795 TEQIHSLSIEAKSKDVKIEVLQNELDDVQLQ----FSEQSTLIRSLQSQLQNKESEVLEG 850
Query: 190 ---VKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIE---KAFEVERQELLASNKKK 243
V+ + + +++ L + E ++ + + E+ ++E + E + Q++ +
Sbjct: 851 AERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSM 910
Query: 244 WEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQI-LEQQL 302
E+ +Q + K L +K +++ L+R EE +++ + +V L+Q
Sbjct: 911 TEKMVQLNEEKFS--LGVEIKTLKEQLNLLSR-----AEEAKKEQVEEDNEVSSGLKQNY 963
Query: 303 QQRKAIYQLNQEKLEYNLQVLKKRDEE-------STVIKSQQKRKINRLHDILNNLRSKY 355
+ Q+++E+L++ +LKK +E+ + + + + ++++RL + L NL+ +
Sbjct: 964 DEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 1023
Query: 356 AKQIKQFQEENQSLTSD 372
K+I + E + D
Sbjct: 1024 KKEIPLSETERGEVEED 1040
Score = 52.0 bits (123), Expect = 2e-06
Identities = 88/408 (21%), Positives = 180/408 (44%), Gaps = 75/408 (18%)
Query: 11 DPNVDEHLSTQILAPSVHSDN-------SQERIQARRLRIAARLEARRREALGE---YLD 60
D + D+++ L P +H ++ +QE +Q RL A +L ++ + + L
Sbjct: 19 DDDTDQNMRAP-LDPELHQESDMEFNNTTQEDVQ-ERLAYAEQLVVELKDIIRQKDVQLQ 76
Query: 61 GKKESEEDQSKSY-----KQKEESRLKLAKL--------LLCGTELVTNIQVAIDIREIH 107
K E+ +++ K+ K K ++ KL L GT L T Q + +
Sbjct: 77 QKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHD 136
Query: 108 RRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGL 167
+ EEE++ IEK++++++ ++ + ++ + + ++ Q EM + +
Sbjct: 137 KSSTEEEME---IEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEM--EEFVMMKQQ 191
Query: 168 LEDKNKLISELQQEL-KTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIE 226
L++K + IS LQ +L +T+ +Q + + ++ D R E QV+ +EL +
Sbjct: 192 LQEKEEFISTLQAQLSQTQAEQAAQQVVREKD------ARFETQVR----LHEDELLQLV 241
Query: 227 KAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQL-NRQRIWDCEEYN 285
+VE + +Q L+ +K+E++E+ L R ++ D +
Sbjct: 242 TQADVETE---------MQQKLRV-----------LQRKLEEHEESLVGRAQVVDLLQQE 281
Query: 286 MIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLH 345
+ EQ QIL QQLQQ +A + + +E EES ++ + + ++
Sbjct: 282 LTAA--EQRNQILSQQLQQMEAEHNTLRNTVE-------TEREESKILLEKMELEVAERK 332
Query: 346 DILNNLRSKYAKQIKQFQEENQS---LTSDYKRLVMQFK-ELQKAMRH 389
+NL+ + ++QF++ Q+ L S Y L + K E+++ H
Sbjct: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/380 (20%), Positives = 157/380 (41%), Gaps = 66/380 (17%)
Query: 40 RLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQV 99
+L + A+ R + L L K+ E+ + + K++ + KL L+ E
Sbjct: 1442 QLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA------ 1495
Query: 100 AIDIREIHRRVEEEEIKRQRIEKL-------ENEVKTSQDKFDEITSKW---EEGKQKRI 149
++E EE + R IE+L E++V + D + + +E + K I
Sbjct: 1496 ---LKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI 1552
Query: 150 PQELWEMLNTQQLHCA---------GLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDI 200
+ +L Q L + GL EDK KL+ E+ + LK+ + +++ ++
Sbjct: 1553 TEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEI-ESLKSSKIAESTEWQEKHKEL 1611
Query: 201 CLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLA------SNKKKWEQALQAHNAK 254
E + + +NV E + ++ +A E+QEL +NKK+ E+ LQ +
Sbjct: 1612 QKEYEILLQSYENVSNE-AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQ-EAEQ 1669
Query: 255 ELEYLNNRMKKVEDYEKQLNRQRIWDCEEYN----------------MIKIKLEQDVQIL 298
E+E + +M+K + +Q+I + EE N ++ L + +
Sbjct: 1670 EMEEMKEKMRKF----AKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNAS-M 1724
Query: 299 EQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINR--------LHDILNN 350
+++L++ K Y+ +K + + EE +K Q + +++ HD N
Sbjct: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784
Query: 351 LRSKYAKQIKQFQEENQSLT 370
+ + + I EE SL+
Sbjct: 1785 VTEEGTQSIPGETEEQDSLS 1804
Score = 48.5 bits (114), Expect = 2e-05
Identities = 81/361 (22%), Positives = 158/361 (43%), Gaps = 55/361 (15%)
Query: 70 SKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEK-LENEVK 128
S+S + + ++K E+ +Q ++E +EEE+ K + + LENE
Sbjct: 1812 SESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKN 1871
Query: 129 TSQDKFDEITSKWEEGKQKRIPQELWEM-LNTQQLHCAGLLEDKNKLISELQQELKTKDD 187
T +I++K +G+ K + +E+ +M L QQ+ L KL ++E ++
Sbjct: 1872 TL---LSQISTK--DGELKMLQEEVTKMNLLNQQIQEE--LSRVTKLKETAEEEKDDLEE 1924
Query: 188 QYVKDLKKQSDDICLLLERMEE-QVKNVMKTFREELYNIEKA---FEVERQELLASN--- 240
+ + L + + I + + + Q+KN + E+ N++K E E+Q+L+
Sbjct: 1925 RLMNQLAELNGSIGNYCQDVTDAQIKNEL--LESEMKNLKKCVSELEEEKQQLVKEKTKV 1982
Query: 241 ----KKKWEQALQA--------HNAKEL-EYLNNRMKKVEDYEKQLNR--QRIWDCEE-- 283
+K++ + +Q +AKEL E L + ++V+ +K R ++I E
Sbjct: 1983 ESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTV 2042
Query: 284 --YNMIKIKLEQDVQILEQQLQQ-----RKAIYQLNQEK-------------LEYNLQVL 323
++ + ++D++I ++ L Q +KA +L K L NL++
Sbjct: 2043 KALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLK 2102
Query: 324 KKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKEL 383
K+ +KSQ K+K L L K+ K+ K QE+ +L + L E+
Sbjct: 2103 KELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEI 2162
Query: 384 Q 384
Q
Sbjct: 2163 Q 2163
Score = 48.1 bits (113), Expect = 3e-05
Identities = 141/733 (19%), Positives = 281/733 (38%), Gaps = 137/733 (18%)
Query: 67 EDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAID-----IREIHRRVEEEEIKRQRIE 121
E+ S++ QKE K+ +LLL V +Q I+ + EI + E+ ++ +
Sbjct: 862 EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEK 921
Query: 122 -KLENEVKTSQDKFDEITSKWEEGKQKRIPQ--ELWEML--NTQQLHCAGLLEDKNKLIS 176
L E+KT +++ + + S+ EE K++++ + E+ L N ++ AG + +
Sbjct: 922 FSLGVEIKTLKEQLN-LLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKE----- 975
Query: 177 ELQQE---LKTKDDQYVKDLKK---QSDDICLLLERMEEQVKNVMKTFREELYNIEKAFE 230
ELQ E LK +++Q + L+ ++ + R+EE++ N+ ++E+ E
Sbjct: 976 ELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEI----PLSE 1031
Query: 231 VERQELLASNK-KKWEQALQAHNAKELE-YLNNRMKKVEDYEKQLNRQRIW-DCEEYNMI 287
ER E+ + K++ + +E+E YL + EK++ Q I D EE
Sbjct: 1032 TERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTIS-----EKEVELQHIRKDLEEKLAA 1086
Query: 288 KIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKR--------------------- 326
+ + + V+ + Q LQ + L Q ++ N +++K
Sbjct: 1087 EEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVV 1146
Query: 327 ----------------DEESTVIKSQQKRKINRLHDILNNLRS---KYAKQIKQFQEENQ 367
+E+ ++ ++++ +L + L + ++ K ++ + +EE +
Sbjct: 1147 ISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELK 1206
Query: 368 SLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHH 427
DY RL QF E K + D + +I + + K
Sbjct: 1207 QQKDDYNRLQEQFDEQSKENENIG--DQLRQLQIQVRESIDGK----------------- 1247
Query: 428 LGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQI 487
LP QQ S+T +EE L ++ E+ + E D P
Sbjct: 1248 --LP-------------STDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHS 1292
Query: 488 SEKTTK---------RILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIE 538
+ + + + + +E K+ S L + + +L + G+E
Sbjct: 1293 EDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLE 1352
Query: 539 SEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEK 598
E K V+ + A L L+ A +E + +L+ ++ + E+
Sbjct: 1353 IES--LKTVSHEAEVHAESLQQKLESSQLQIAGLEHL----RELQPKLDELQKLISKKEE 1406
Query: 599 EESLVEGEKEEEEE--TPPSPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNS 656
+ S + G+ E+E T +I D++K L + K D R +
Sbjct: 1407 DVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQ 1466
Query: 657 KDSEYWQALTTVIPSSKQNLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQ 716
K E + +KQ + L A L R + L EN SL+++ + + ++
Sbjct: 1467 KPEEIGEE-----SRAKQQIQRKLQAA-------LISRKEALKENKSLQEELSLARGTIE 1514
Query: 717 QYLNSKINSELQV 729
+ S + E QV
Sbjct: 1515 RLTKSLADVESQV 1527
Score = 46.6 bits (109), Expect = 8e-05
Identities = 97/473 (20%), Positives = 198/473 (41%), Gaps = 65/473 (13%)
Query: 33 QERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
QE+I A + A LE + E+ + L+ KE+ Q+ +++K ++ L K+LL T+
Sbjct: 2032 QEKISALERTVKA-LEFVQTESQKD-LEITKENLA-QAVEHRKKAQAELASFKVLLDDTQ 2088
Query: 93 ------LVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQ 146
L N+++ +++ V+ + +Q+ E LE ++ +++K K+
Sbjct: 2089 SEAARVLADNLKLKKELQSNKESVKSQ--MKQKDEDLERRLEQAEEK---------HLKE 2137
Query: 147 KRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLER 206
K+ QE + L +++H + I E+Q L KD + V+ L++ D L
Sbjct: 2138 KKNMQEKLDALRREKVHL-------EETIGEIQVTLNKKDKE-VQQLQENLDSTVTQLAA 2189
Query: 207 MEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKV 266
+ + ++ + ++ + KKWE+ + E + +
Sbjct: 2190 FTKSMSSLQ----------------DDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNC 2233
Query: 267 EDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLE-YNLQVLKK 325
+ QL + I EE + +LE D QI E + Q + Q + L+ N ++L +
Sbjct: 2234 SVLKDQLRQMSI-HMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQ 2292
Query: 326 RDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQK 385
+E + S Q N +K ++K +++ L++ ++ Q L+
Sbjct: 2293 LEETRHLYHSSQ------------NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEG 2340
Query: 386 AMR-HFALIDDEKF-WEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNV 443
+R A I + KF +E + + +++L +R + + + L + + +
Sbjct: 2341 IIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISL-LSGKEEAIQVAI 2399
Query: 444 GPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISE--KTTKR 494
+ QQ K ++ E L+ EEEE E + +D Q+ E KT K+
Sbjct: 2400 AELRQQHDKEIKEL--ENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKK 2450
Score = 45.1 bits (105), Expect = 2e-04
Identities = 83/376 (22%), Positives = 154/376 (40%), Gaps = 42/376 (11%)
Query: 7 LEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESE 66
L L ++EH + + V QE A + + ++ EA L E+E
Sbjct: 254 LRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETE 313
Query: 67 EDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENE 126
++SK +K E + KL N+Q E+H +E+ E Q +LE+
Sbjct: 314 REESKILLEKMELEVAERKLSF------HNLQ-----EEMHHLLEQFEQAGQAQAELESR 362
Query: 127 VKTSQDK----FDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQEL 182
+ K +E TS ++ QEL + + + LL+DKN+ + Q +
Sbjct: 363 YSALEQKHKAEMEEKTS--HILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI 420
Query: 183 KTKDDQYVKDLKKQSDDICLLLERME-EQVKNVMKTFREELYNIEKAFEVERQELLASNK 241
+ +DQ L+++S +I L R+ +Q + +T ++YN + + +E +AS +
Sbjct: 421 QQLEDQ----LQQKSKEISQFLNRLPLQQHETASQTSFPDVYN--EGTQAVTEENIASLQ 474
Query: 242 K--------KWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCE--EYNMIKIKL 291
K K L + +EL+ N ++ + NR D E E +++ I
Sbjct: 475 KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIAN 534
Query: 292 EQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIK--SQQKRKINRLHDILN 349
++ E + + ++L L +K+ EE +K Q KR H++L+
Sbjct: 535 KRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLD 594
Query: 350 NLRSKYAKQIKQFQEE 365
K++KQ + E
Sbjct: 595 Q------KEMKQMEGE 604
Score = 41.2 bits (95), Expect = 0.004
Identities = 121/564 (21%), Positives = 217/564 (38%), Gaps = 90/564 (15%)
Query: 62 KKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIE 121
K E EE K+KE+ + KL + L ++ Q +E H R EE+K+Q+
Sbjct: 1159 KPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQE----KERHLR---EELKQQK-- 1209
Query: 122 KLENEVKTSQDKFDEITSKWEE-GKQKRIPQ-ELWEMLN------TQQLHCAGL--LEDK 171
++ Q++FDE + + E G Q R Q ++ E ++ QQ C+ LE+
Sbjct: 1210 ---DDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEP 1266
Query: 172 NKLISELQQELKTKDDQYVKDLKKQSDDICLLLERME-EQVKNVMKTFREELYNIEKAFE 230
+E + D S+D L Q+K +K E +E
Sbjct: 1267 LFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVS 1326
Query: 231 VERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIK 290
EL KK E+ Q ++Q+N+Q + E +K
Sbjct: 1327 STTSELT----KKSEEVFQL-------------------QEQINKQGL----EIESLKT- 1358
Query: 291 LEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNN 350
+ + ++ + LQQ+ QL LE+ ++ K DE +I S+++ ++ L L+
Sbjct: 1359 VSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLI-SKKEEDVSYLSGQLSE 1417
Query: 351 LRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFAL-IDDEKFWEIWLMNEEEA 409
+ K + E+ + + + +L MQ KE + ++ + + + K + E A
Sbjct: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
Query: 410 KDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEM-LMRSEEE 468
K I R I L K + EE+ L R E
Sbjct: 1478 KQQIQRKLQAALISRKEAL-----------------------KENKSLQEELSLARGTIE 1514
Query: 469 EAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRL 528
++ A+ ES + + + R L LL +E LI SLL +N+
Sbjct: 1515 RLTKSLADVESQVSAQNKEKDTVLGR-LALLQEERDKLITEMDRSLL----ENQSLSSSC 1569
Query: 529 DAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELEL 588
+++ AL +ED KLV ++ +++ S + + EK + L+
Sbjct: 1570 ESLKLALEGLTEDK-EKLVKEIESLKSSKIAESTEWQ-------EKHKELQKEYEILLQS 1621
Query: 589 AEQTEMEGEKEESLVEGEKEEEEE 612
E E E+ + +VE ++E++E
Sbjct: 1622 YENVSNEAERIQHVVEAVRQEKQE 1645
Score = 40.4 bits (93), Expect = 0.006
Identities = 73/376 (19%), Positives = 150/376 (39%), Gaps = 34/376 (9%)
Query: 59 LDGKKESEEDQS----KSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEE 114
L GK+ E D K KQ E + K+ + + + + + VE+E+
Sbjct: 580 LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ 639
Query: 115 IKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKL 174
+ + E+ + D E+ S ++G + L + + Q H L K+++
Sbjct: 640 ASTEHQSRTSEEISLN-DAGVELKSTKQDGDKS-----LSAVPDIGQCHQDELERLKSQI 693
Query: 175 ISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQ 234
+ EL+ + Y K+L +++ +I L + +EE KN + + A ER
Sbjct: 694 L-ELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNA-----DNNSSAFTALSEERD 747
Query: 235 ELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQD 294
+LL+ Q + L ++K++E + RQR D E L +
Sbjct: 748 QLLS----------QVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQ 797
Query: 295 VQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLR-- 352
+ L + + + ++ Q +L+ V + E+ST+I+S Q + N+ ++L
Sbjct: 798 IHSLSIEAKSKDVKIEVLQNELD---DVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERV 854
Query: 353 ---SKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEA 409
S +++ Q + + + +L+++ K + ++ D++ EI E+
Sbjct: 855 RHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Query: 410 KDLIARAFDVDRIIHT 425
L F + I T
Sbjct: 915 VQLNEEKFSLGVEIKT 930
Score = 37.0 bits (84), Expect = 0.066
Identities = 142/763 (18%), Positives = 304/763 (39%), Gaps = 116/763 (15%)
Query: 64 ESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQ-----VAIDIREIHRRVE----EEE 114
E + D + EE ++ ++ TE + + + ++I+ + ++ EE
Sbjct: 884 EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEE 943
Query: 115 IKRQRIEKLENEVKTS-QDKFDEITSKWEEGKQKRIPQ-ELWEMLNTQQLHC--AGLLED 170
K++++E+ +NEV + + +DE++ + K++ + +L + N Q+ A L+
Sbjct: 944 AKKEQVEE-DNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINR 1002
Query: 171 KNKL--ISELQQELKTKDDQYVKDL---------------KKQSDDICLL--LERMEEQV 211
K L +S L++EL D+ K++ K+ + C+ + +E +
Sbjct: 1003 KELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYL 1062
Query: 212 KNVMKTFREELYNIEKAFE--VERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDY 269
K + EL +I K E + +E + K+ Q LQ +++ L + + +
Sbjct: 1063 KQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQ-DKTNQIDLLQAEISENQAI 1121
Query: 270 EKQL--NRQRIWDCEEYNMIK------------------------IKLEQDVQILEQQLQ 303
++L + D + ++K + LE++ + L+++LQ
Sbjct: 1122 IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQ 1181
Query: 304 Q----RKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQ---QKRKINRLHDILNNLRSKYA 356
+ RKAI + QEK + + LK++ ++ ++ Q Q ++ + D L L+ +
Sbjct: 1182 EALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVR 1241
Query: 357 KQI-----KQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKD 411
+ I Q+E+ S T + + + E H + + W + E+A
Sbjct: 1242 ESIDGKLPSTDQQESCSSTPGLEEPLFKATE----QHHTQPVLESNLCPDWPSHSEDASA 1297
Query: 412 LIA-----------RAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEE 460
L + + +++ L L ++ + Q ++ Q +E
Sbjct: 1298 LQGGTSVAQIKAQLKEIEAEKV----ELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
Query: 461 MLMRSEEEEAEEAAAEPESYLDLPK-QISEKTTKRILMLLCDESGFLIESK---LLSLLL 516
+++ EAE A + L+ + QI+ R L DE LI K + L
Sbjct: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSG 1413
Query: 517 PLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLS---SSLQIKPCSQASME 573
L + E L ++ I ++DL K ++ L+ +A LQ++ C
Sbjct: 1414 QLSEKEAALTKIQT-----EIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP 1468
Query: 574 KASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKILEAFV 633
+ EE+ + +++ Q + K E+L E + +EE + + L +E+ V
Sbjct: 1469 EEIGEESRAKQQIQRKLQAALISRK-EALKENKSLQEELSLARGTIERLTKSLADVESQV 1527
Query: 634 MGLKKPRDS----RAPLRVQKNVRDNSKDSEYW--QALTTVIPSSKQNLWDALYTALEKY 687
K +D+ A L+ +++ D Q+L++ S K L +
Sbjct: 1528 SAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV 1587
Query: 688 HLVLTQRAKLLLENSSLEQQNTELQ----ALLQQYLNSKINSE 726
+ + ++ + E++ ++++ ELQ LLQ Y N +E
Sbjct: 1588 KEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE 1630
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 63.5 bits (153), Expect = 7e-10
Identities = 94/419 (22%), Positives = 196/419 (46%), Gaps = 65/419 (15%)
Query: 50 RRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKL--LLCG-----TELVTNIQVAID 102
R+++ E L ++E E + + +E+ ++L+K ++ G T IQ D
Sbjct: 1884 RQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTD 1943
Query: 103 IREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQL 162
I I R +E R+++LE E + Q++ + ++ + E K + P E + T++L
Sbjct: 1944 I--IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKL 2001
Query: 163 ---------HCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLER---MEEQ 210
+ +D K + L+ +++ + ++++ ++++ ++ L ++ +E+Q
Sbjct: 2002 MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ 2061
Query: 211 VKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQA---------HNAKELEYLNN 261
++ + K E+ + E +V +QE+ +K EQ L+ H +E+E L N
Sbjct: 2062 LEKMRKFLDEQAIDREHERDVFQQEI-----QKLEQQLKVVPRFQPISEHQTREVEQLAN 2116
Query: 262 RMKKVEDY--EKQLNRQRIW-DCEEYNMIKIKLEQDVQILEQQL--QQRK---AIYQLNQ 313
+K+ D E L+++++ D +E N KLE V+ LEQ L + RK A+ +
Sbjct: 2117 HLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPE 2176
Query: 314 EKLEYNLQV----LKKRDEESTVIKSQ----------QKRKINRLHDILNNLRSKYAKQI 359
LE LQ + ++++E T ++ Q + ++ +LH L + + ++
Sbjct: 2177 LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2236
Query: 360 KQFQEENQSLTSDYKRLVMQFKE---LQKAMRH-----FALIDDEKFWEIWLMNEEEAK 410
++ ++EN+ D ++L + KE + +H FA I EK EI +NE+ K
Sbjct: 2237 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 2295
Score = 59.3 bits (142), Expect = 1e-08
Identities = 126/592 (21%), Positives = 246/592 (41%), Gaps = 132/592 (22%)
Query: 102 DIREIHRRVE-EEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQ 160
+++++H ++E +++ R+++LE E K +D +++ +E + ++TQ
Sbjct: 2217 EVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES----------DAMSTQ 2266
Query: 161 QLHC-----AGLLEDK-------NKLISELQQELKTKDD--------QYVKDLKKQ---- 196
H A ++++K N+ +++LQQ+LK D + ++DL+ Q
Sbjct: 2267 DQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2326
Query: 197 -SDDICLLLERME--EQVKNVMKTFREELYNI------------EKAFEVERQ-ELLASN 240
SD C+ R E EQ+ V++ ++EL NI E+A ++ Q +++ +
Sbjct: 2327 MSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE 2386
Query: 241 KKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQ 300
K EQ ++ N +E+ ++ N +K+ QL ++ + +K E++ Q
Sbjct: 2387 KLALEQQVETAN-EEMTFMKNVLKETNFKMNQLTQE---------LFSLKRERESVEKIQ 2436
Query: 301 QLQQRK---AIYQLNQEKLEYNLQVLK---KRDEESTVIKSQQ---KRKINRLHDILNNL 351
+ + AI L+++K E + + + K E T KS + K I L L L
Sbjct: 2437 SIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQL 2496
Query: 352 RSKYA----------KQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEI 401
S + KQIK QE+ Q T ++ ++ +++ + AL+ + +
Sbjct: 2497 ESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV 2556
Query: 402 WLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEM 461
+E AK F + IS +P+++ Q + ++
Sbjct: 2557 ----QEYAK----------------------------FCQDNQTISSEPERTNIQNLNQL 2584
Query: 462 LMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRIL----MLLCDESGFLIESKLLSLLLP 517
E+E + +A +L Q+ E T IL + + +++ E KLL L
Sbjct: 2585 ---REDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKL 2641
Query: 518 LEQNECYLLRLDAIFSALGIESEDDLYKLVN------FFLKYRAHRLSS------SLQIK 565
LE NE + S +E +L + FF + A R S K
Sbjct: 2642 LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYK 2701
Query: 566 PCSQASMEKASMEETS-TRSELELAEQTEMEGEKEESLVEGEKEEEEETPPS 616
++ E+ ++ET+ T + +L++ + E +E L EKE+E E S
Sbjct: 2702 EKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2753
Score = 55.5 bits (132), Expect = 2e-07
Identities = 87/438 (19%), Positives = 189/438 (43%), Gaps = 57/438 (13%)
Query: 19 STQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKES-------EEDQSK 71
+++ L S HS + + +QA++ + + + ++ L E KKE +++ K
Sbjct: 247 ASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIK 306
Query: 72 SYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRI-EKLENEVKTS 130
Y+ +++ +++ + E + + I+ E++ ++ EEE K + +KL K
Sbjct: 307 VYEMEQDKKVENS-----NKEEIQEKETIIE--ELNTKIIEEEKKTLELKDKLTTADKLL 359
Query: 131 QDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKL--ISELQQELKTKDDQ 188
+ ++I K +E K ++ E+ N++Q E K + + ELQ+ KD Q
Sbjct: 360 GELQEQIVQKNQEIKNMKL-----ELTNSKQKERQSSEEIKQLMGTVEELQKR-NHKDSQ 413
Query: 189 YVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVE-RQELLASNKKKWEQA 247
+ D +++RME++ + ++ R EL + V+ +QEL+ + + E+
Sbjct: 414 FETD----------IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM 463
Query: 248 LQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQ---- 303
H E+E + E Q+ + N + IKL QD +++L+
Sbjct: 464 KTRHKG-EMENALRSYSNITVNEDQIKLMNV----AINELNIKL-QDTNSQKEKLKEELG 517
Query: 304 ---QRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQI- 359
+ K Q E L L +++ + + ++Q+ K+N H L+ + A+ +
Sbjct: 518 LILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVS 577
Query: 360 -----KQFQEENQSLTSDYK-RLVMQFKELQKAMRHFALIDD---EKFWEIWLMNEEEAK 410
K+ + ++++ ++YK +L M KE + A + E+ L + EE
Sbjct: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637
Query: 411 DLIARAFDVDRIIHTHHL 428
+ +++ I+ L
Sbjct: 638 SKLKEDLEIEHRINIEKL 655
Score = 47.4 bits (111), Expect = 5e-05
Identities = 78/322 (24%), Positives = 140/322 (43%), Gaps = 51/322 (15%)
Query: 7 LEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESE 66
LE D + HL LA E+ ++R L+ A E + LG + KE
Sbjct: 3186 LEVKDKTDEVHLLNDTLA--------SEQKKSRELQWALEKEKAK---LGRSEERDKEEL 3234
Query: 67 EDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENE 126
ED S + +++ L+L LL +L+ Q I E R + + ++ ++ LE +
Sbjct: 3235 EDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKI---ESQRMLYDAQLSEEQGRNLELQ 3291
Query: 127 VKTSQDK--FDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKT 184
V +K E++S + +++ + +L T Q ED L+ ELQ++L+
Sbjct: 3292 VLLESEKVRIREMSSTLD--RERELHAQLQSSDGTGQSRPPLPSED---LLKELQKQLEE 3346
Query: 185 KDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKW 244
K + V+ LL E+ + ++T ++ +EK +V R+ L
Sbjct: 3347 KHSRIVE-----------LLNETEKYKLDSLQTRQQ----MEKDRQVHRKTL-------- 3383
Query: 245 EQALQAHNAKELEYLNNRMKKVEDYEKQL--NRQRIW--DCEEYNMIKIKLEQDVQIL-- 298
Q Q N + + ++ KVED ++QL RQ+++ D E + I E Q L
Sbjct: 3384 -QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELER 3442
Query: 299 EQQLQQRKAIYQLNQEKLEYNL 320
E++ + R+ +YQ E ++L
Sbjct: 3443 EEKRESRRILYQNLNEPTTWSL 3464
Score = 41.6 bits (96), Expect = 0.003
Identities = 48/217 (22%), Positives = 90/217 (41%), Gaps = 21/217 (9%)
Query: 170 DKNKLISELQ---------------QELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNV 214
D+ L+SE+Q ++ K Q + + Q +L ++E
Sbjct: 3078 DRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKD 3137
Query: 215 MKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNA--KELEYLNNRMKKVEDYEKQ 272
T +E + EK E + LA K + E L+A + KELE +K D
Sbjct: 3138 RATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHL 3197
Query: 273 LNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTV 332
LN + ++ ++ LE++ L + ++ K E L+++L+ K+R+ + +
Sbjct: 3198 LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE----ELEDLKFSLESQKQRNLQLNL 3253
Query: 333 IKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSL 369
+ QQK+ +N + + R Y Q+ + Q N L
Sbjct: 3254 LLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLEL 3290
Score = 40.0 bits (92), Expect = 0.008
Identities = 57/234 (24%), Positives = 105/234 (44%), Gaps = 30/234 (12%)
Query: 170 DKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREE------LY 223
+K+K + L++EL ++ +K+L+K + ++E Q +T E +
Sbjct: 1138 EKDKALCSLKEELIFAQEEKIKELQK--------IHQLELQTMKTQETGDEGKPLHLLIG 1189
Query: 224 NIEKAFEVE----RQELLASNKKKWEQALQAH-NAKELEYLNNRMKKVEDYEKQLNRQRI 278
++KA E Q L + + + AL+ NA++ E + + + ED E Q R +
Sbjct: 1190 KLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEV 1249
Query: 279 WDCEE--YNMIKIKLEQDVQILEQQLQQRKAI-YQLNQEKLEYNLQVLKKRDEESTVIKS 335
D +E + ++ E+ ++L Q + K Q + KLE+ + L K + E I S
Sbjct: 1250 QDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHS 1309
Query: 336 QQKRKINRLHDILNNLRSKYAK----QIKQFQEENQSLTSDYKRLVMQFKELQK 385
Q + L DI N +SK + + + +E+ Q L S L Q KE ++
Sbjct: 1310 Q----MTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQ 1359
Score = 36.2 bits (82), Expect = 0.11
Identities = 46/199 (23%), Positives = 81/199 (40%), Gaps = 17/199 (8%)
Query: 220 EELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIW 279
E L +++ F ER LLA+ + + L L R++ E+ + Q
Sbjct: 3017 ELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQ-----EQGVEYQAAM 3071
Query: 280 DCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEK-------LEYNLQVLKKRDEESTV 332
+C + + L ++Q L Q+ RK + QE LEYN+Q + + E V
Sbjct: 3072 ECLQ-KADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3130
Query: 333 IKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFAL 392
S K + L + L++ + A+ + + L + K KEL+ F L
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEA----FRL 3186
Query: 393 IDDEKFWEIWLMNEEEAKD 411
+K E+ L+N+ A +
Sbjct: 3187 EVKDKTDEVHLLNDTLASE 3205
Score = 33.1 bits (74), Expect = 0.96
Identities = 43/198 (21%), Positives = 85/198 (42%), Gaps = 31/198 (15%)
Query: 104 REIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLH 163
+EI +EE E +Q+ +L E++ ++ F +E Q+ + +E +L +
Sbjct: 820 KEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE-LQEEYACLLKVKD-- 876
Query: 164 CAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELY 223
L + KNK E + +LK +++ I +M+ V + KTF E
Sbjct: 877 --DLEDSKNKQELEYKSKLKALNEEL------HLQRINPTTVKMKSSVFDEDKTFVAETL 928
Query: 224 NIEKAFEVERQELL----ASNKKKW----------EQALQAHNAKELEYLNNRMKKVEDY 269
+ + E + EL+ + ++K EQ Q H E+ +LN +K ++
Sbjct: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG--EISFLNEEVKSLKQE 986
Query: 270 EKQLNRQRIWDCEEYNMI 287
++Q++ + C E +I
Sbjct: 987 KEQVSLR----CRELEII 1000
Score = 32.7 bits (73), Expect = 1.2
Identities = 42/213 (19%), Positives = 98/213 (46%), Gaps = 23/213 (10%)
Query: 192 DLKKQSDDICL-LLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQA 250
++ +++++ L + R++ V+ +++ E +E A +V + EL+ + ++ ++A ++
Sbjct: 1834 EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATES 1892
Query: 251 HNAKE------------LEYLNNRMKKVEDY------EKQLNRQRIWDCEEYNMIKIKLE 292
+E E L + K E EK L ++I +E I +LE
Sbjct: 1893 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQI---QEKTDIIDRLE 1949
Query: 293 QDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLR 352
Q++ +LQ+ +A Q QE+ E + + E+ ++ Q ++ +L ++
Sbjct: 1950 QELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQ 2009
Query: 353 SKYAKQIKQFQEENQSLTSDYKRLVMQFKELQK 385
+ K Q++ ++L D + V +F EL++
Sbjct: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
Score = 32.7 bits (73), Expect = 1.2
Identities = 73/368 (19%), Positives = 151/368 (41%), Gaps = 55/368 (14%)
Query: 42 RIAARLEAR-RREALGEY---------LDGKKESEEDQSKSYKQKEESRLKLAKLLLCGT 91
++AA L ++ + EA+ EY + + E Q+ + +++E ++ L L +
Sbjct: 2542 KVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRIS 2601
Query: 92 ELVTNIQVAIDIREIHRRV----EEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQK 147
EL + + E+H + E+ EI + + + E ++ Q + K E ++K
Sbjct: 2602 ELESQVV------EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKK 2655
Query: 148 RIPQELWEMLNTQQLHCAGLLEDKNKLISELQ----QELKTKDD--QYVKDLKKQSDDIC 201
R PQ++ + T +L + +++ +EL+ + + TK + Y + +K +++
Sbjct: 2656 RSPQDVEVLKTTTELFHS---NEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL 2712
Query: 202 L------LLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKE 255
+ L++ QV++ + +E+L +EK E E QE S K + L +K
Sbjct: 2713 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE---SKKACMFEPLPIKLSKS 2769
Query: 256 LEYLNNRMKKVEDYEK-----------QLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQ 304
+ + K+ + Q+N Q EE I + + + +++Q+
Sbjct: 2770 IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI----EKMQE 2825
Query: 305 RKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQE 364
A L+ E + KR E V K + L ++ LRSK I +
Sbjct: 2826 LHAAEILDMESRHISETETLKR--EHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAH 2883
Query: 365 ENQSLTSD 372
+ T +
Sbjct: 2884 SDAYQTRE 2891
Score = 32.0 bits (71), Expect = 2.1
Identities = 54/245 (22%), Positives = 103/245 (42%), Gaps = 41/245 (16%)
Query: 111 EEEEIKR-QRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLE 169
+EE+IK Q+I +LE + +Q+ DE K + + ++ C+ L+
Sbjct: 1154 QEEKIKELQKIHQLELQTMKTQETGDE---------GKPLHLLIGKLQKAVSEECSYFLQ 1204
Query: 170 DKNKLISE-----LQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYN 224
++ E L+ E+ +D + D +++D L R E Q F+E ++
Sbjct: 1205 TLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQ------DFQENMHT 1258
Query: 225 IEKAFEVERQELLASN---KKKWEQALQAHNAK---------ELEYLN--NRMKKVEDYE 270
+ E +LL K W Q + E E+L+ ++M +ED +
Sbjct: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318
Query: 271 KQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDE-- 328
++ ++ ++ K KLE+ VQ LE + + + ++ E + L+KR +
Sbjct: 1319 VN-HKSKLSSLQDLE--KTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAV 1375
Query: 329 -ESTV 332
ESTV
Sbjct: 1376 SESTV 1380
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 63.5 bits (153), Expect = 7e-10
Identities = 131/651 (20%), Positives = 264/651 (40%), Gaps = 100/651 (15%)
Query: 21 QILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESR 80
Q+L D + ++A + + +E E L K ++ E ++ Q +E
Sbjct: 513 QVLRQIGDKDQKIQNLEALLQKSKENISLLEKER--EDLYAKIQAGEGETAVLNQLQEKN 570
Query: 81 LKLAKLLLCGTELVTNIQVAIDIREIHRRVEE---EEIKRQR--IEKLENEVKTSQDKFD 135
L + + TE + N E H++ +E ++++ Q+ + ++ V + + +
Sbjct: 571 HTLQEQVTQLTEKLKNQS------ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
Query: 136 EITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDD------QY 189
E+ S+ E K+K ++ T+ L A + + ++LQ L T + Q
Sbjct: 625 ELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR--ADLQNHLDTAQNALQDKQQE 682
Query: 190 VKDLKKQSDDICLLLERMEE---QVKNVMKTFREELYNIE----------KAFEVERQEL 236
+ + Q D + L+ +E Q+++ +K ++E+ ++E K E + E+
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
Query: 237 LASNKKKWEQALQAHNAK-ELEYLNNRMKKVEDYEKQLNRQRIWDC----EEYNMIKIKL 291
AS ++ + Q +LE + K + EK++ D E IK KL
Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 292 ---EQDVQILEQQLQQRKAIYQLNQEKLE-------YNLQVLKKRDEESTVIKSQQKRKI 341
E++ QIL+Q + ++ E+L LQ +K E S K K+
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 342 NRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFK-ELQKAMRHFALIDDEKFWE 400
+++ D L N +S++ K+ ++ ++ D ++ + K +LQ M + + ++K +
Sbjct: 863 SKVSDSLKNSKSEFEKE----NQKGKAAILDLEKTCKELKHQLQVQMEN--TLKEQKELK 916
Query: 401 IWLMNEEEAKDLIARAFD--VDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQI- 457
L E+EA + + +++I + + N+ + Q ++ QI
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
Query: 458 ---------------VEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDE 502
+E L + + A+E AAE E + + + EK+ + L D
Sbjct: 977 ALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK-ISVLQNNYEKSQETFKQLQSDF 1035
Query: 503 SGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSL 562
G ES+LL+ L+ E L + ED + ++R
Sbjct: 1036 YG--RESELLATRQDLKSVE----------EKLSLAQEDLI-----------SNRNQIGN 1072
Query: 563 QIKPCSQASMEKASMEETSTRSELELAEQTE--MEGEKEESLVEGEKEEEE 611
Q K + KA++E+ S + E +L E+ + + +KE+SL E E E+
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEK 1123
Score = 58.5 bits (140), Expect = 2e-08
Identities = 107/457 (23%), Positives = 199/457 (43%), Gaps = 94/457 (20%)
Query: 36 IQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVT 95
++ R ++ +LE + LD +K+SE +S KQK + + ++L E ++
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEA--LESIKQKLTKQEEEKQILKQDFETLS 820
Query: 96 NIQVAIDIREIHRRVEEEEIKRQRI----EKLENEVKTSQDKFDEIT-------SKWEEG 144
+ I E++ R++ + Q++ E L E+ T +DK +++ S++E+
Sbjct: 821 Q-ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879
Query: 145 KQK---------RIPQELWEMLNTQ-------QLHCAGLLEDKNKLISELQQELKTKDDQ 188
QK + +EL L Q Q LE + + +L+ EL + +Q
Sbjct: 880 NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939
Query: 189 YVK--------------------DLKKQSDDICLLLERMEEQVKNVMKTFREELYNI--- 225
++ +LK+ S+ +E ++ ++K + + EL N
Sbjct: 940 LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK-IAVLQKTELENKLQQ 998
Query: 226 -------EKAFEVERQELLASNKKKWEQALQAHNA----KELEYLNNR--MKKVEDY--- 269
E A E E+ +L +N +K ++ + + +E E L R +K VE+
Sbjct: 999 QLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1058
Query: 270 -EKQL--NRQRIWD----CEEYNMIKIKLEQDVQILEQQLQQR-KAIYQLNQEK--LEYN 319
++ L NR +I + +E K LEQD EQQLQ+R KA+ + +EK E
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE 1118
Query: 320 LQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQ 379
L K + E IK +Q+++I +L++ L + + + K+I ++ Q L+ Q
Sbjct: 1119 LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ-------LLIQQ 1171
Query: 380 FKELQ-KAMRHFALIDDEKFWEIWLMNEEEAKDLIAR 415
ELQ KA A ++ EK N++ KD + +
Sbjct: 1172 KLELQGKADSLKAAVEQEK------RNQQILKDQVKK 1202
Score = 58.2 bits (139), Expect = 3e-08
Identities = 143/722 (19%), Positives = 296/722 (40%), Gaps = 90/722 (12%)
Query: 37 QARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTN 96
+ ++L+ + ++ + L E L K++ + + ++ S+ + L
Sbjct: 289 ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQ 348
Query: 97 IQVAIDIRE--IHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQE-- 152
+Q + E +HR E K + +KL+ E+ + K+ + +++++ +Q+R +E
Sbjct: 349 LQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH 408
Query: 153 -LWEMLNTQQLHCAGLLEDKNKLISELQQELKTK---DDQYVKDLKKQSDDICLLLERME 208
L QLH + LLE + +L E LK + + + D ++Q D+ L L R+E
Sbjct: 409 GLQLQSEINQLH-SKLLETERQL-GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
Query: 209 EQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKE--LEYLNNRMKKV 266
EQ+K + E + ++K + + QE A + + +A N E L + ++ +K+
Sbjct: 467 EQLKEKVTNSTELQHQLDKT-KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 525
Query: 267 EDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKR 326
++ E L + + E ++++ K +D+ Q + A+ QEK + + +
Sbjct: 526 QNLEALLQKSK----ENISLLE-KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL 580
Query: 327 DEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKA 386
E+ K+ LHD + ++ ++ Q+ SL + L Q E ++
Sbjct: 581 TEKLKNQSESHKQAQENLHDQVQEQKA----HLRAAQDRVLSLETSVNELNSQLNESKEK 636
Query: 387 MRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPI 446
+ + K L++ E AK A+ D+ + T N +
Sbjct: 637 VSQLDI--QIKAKTELLLSAEAAK--TAQRADLQNHLDTAQ-------------NALQDK 679
Query: 447 SQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFL 506
Q+ K TQ+ + + ++ ++ +E ++ ES+L K+
Sbjct: 680 QQELNKITTQLDQ---VTAKLQDKQEHCSQLESHLKEYKE-------------------- 716
Query: 507 IESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKL-----VNFFLKYRAHRLSSS 561
K LSL E+ E + +L+A + E L L +N L+ RA LS
Sbjct: 717 ---KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
Query: 562 LQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKE-----EEEETPPS 616
L+ MEK E + + L+L +++E ++ L + E+E ++ ET
Sbjct: 774 LE--------MEK----EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
Query: 617 PWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQ-KNVRDN-SKDSEYWQALTTVIPSSKQ 674
I ++ ++ V L+K + + L + V+D SK S+ + + Q
Sbjct: 822 ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
Query: 675 NLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLNSKINSELQVPPTQV 734
A LEK L + ++ +EN+ EQ+ + ++ + ++ EL Q+
Sbjct: 882 K-GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940
Query: 735 LR 736
++
Sbjct: 941 IQ 942
Score = 48.9 bits (115), Expect = 2e-05
Identities = 135/656 (20%), Positives = 265/656 (40%), Gaps = 77/656 (11%)
Query: 113 EEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQK--RIPQEL------WEMLNTQQLHC 164
+++ Q+ +L E+ + K+DE S E +QK R+ +EL + L T+ L
Sbjct: 158 KDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQR 217
Query: 165 AGLLEDKNKLISELQQELKTKDDQYVKDLKKQSD---DICLLLERMEEQVKNVMKTFREE 221
G +ED L EL Q ++T D + +++S+ D C L+ + + R E
Sbjct: 218 PG-IEDVAVLKKELVQ-VQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSE 275
Query: 222 LYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDC 281
L + V QEL +K + ++ K N +KK +DY K +
Sbjct: 276 LAKGPQEVAVYVQEL-----QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESV 330
Query: 282 EEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKI 341
+ N+ ++D+ QQLQ R + + + ++ L E + K ++
Sbjct: 331 SKKNIQATLHQKDLDC--QQLQSRLSASETSLHRIHVEL-------SEKGEATQKLKEEL 381
Query: 342 NRLHDILNNLRSKYAKQIKQFQEENQ----SLTSDYKRLVMQFKELQKAM--RHFALIDD 395
+ + +L++++ KQ++Q +EE + L S+ +L + E ++ + H L +
Sbjct: 382 SEVETKYQHLKAEF-KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ 440
Query: 396 EKFWEIWLMN-EEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSA 454
+ LM+ E++ DL + ++ + + N + Q K+
Sbjct: 441 RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK-------------VTNSTELQHQLDKTK 487
Query: 455 TQIVEEM-LMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLS 513
Q E+ L +S + EA + E L +QI +K K + + L +SK
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVL---RQIGDKDQK-----IQNLEALLQKSKENI 539
Query: 514 LLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCS-QASM 572
LL E+ + Y I + G + + + N L+ + +L+ L+ + S + +
Sbjct: 540 SLLEKEREDLYA----KIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 573 EKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKILEAF 632
E + ++ L A+ + E + + + E +E + +L A
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE 655
Query: 633 VMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALT-----TVIPSSKQNLWDALYTALEKY 687
+ D + L +N + K E + T T KQ L + L++Y
Sbjct: 656 AAKTAQRADLQNHLDTAQNALQD-KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714
Query: 688 ---HLVLTQRAKLL------LENSSLEQQNTELQALLQQYLNSKINSELQVPPTQV 734
+L L Q+ + L LE SLE + ++ QAL ++N++L++ T++
Sbjct: 715 KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATEL 770
Score = 35.8 bits (81), Expect = 0.15
Identities = 49/221 (22%), Positives = 97/221 (43%), Gaps = 32/221 (14%)
Query: 192 DLKKQSDDICLLLERMEEQVKNVMKTFREEL-YNIEKAFEVERQELLASNKKKWEQALQA 250
+L + DD+ LL ++V+++ + +EE Y+ E E+E+ + L + K L
Sbjct: 77 NLALKRDDVTLL----RQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAK-PDGLVT 131
Query: 251 HNAKELEYL----------NNRMKKVEDYEKQLNRQRIWDC-------EEYNMIKIKLEQ 293
++ EL+ L N +K+++D +Q Q + +E ++ EQ
Sbjct: 132 DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQ 191
Query: 294 DVQILEQQLQQRKAIYQ-LNQEKLEY----NLQVLKKRDEESTVIKS----QQKRKINRL 344
V L ++L + + Q L E L+ ++ VLKK + + +++R+ +L
Sbjct: 192 KVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251
Query: 345 HDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQK 385
D L+S+YA + L + + + +ELQK
Sbjct: 252 KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQK 292
Score = 31.6 bits (70), Expect = 2.8
Identities = 39/162 (24%), Positives = 80/162 (49%), Gaps = 35/162 (21%)
Query: 68 DQSKSYKQ---KEESRLKLAKLLLCGTEL-----VTNIQVAIDIREIHRRV-------EE 112
++ KS+K KE + LK AK LL +L +++ A++ + ++++ EE
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
Query: 113 EEIKRQRIEKLENEVKT-SQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDK 171
EE+K++ IEK E K S+ K E+ K E + ++ ++ +
Sbjct: 1205 EELKKEFIEK---EAKLHSEIKEKEVGMKKHEENEAKLTMQITAL--------------- 1246
Query: 172 NKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKN 213
N+ + +++E ++ + V +L+KQ+DD+ + +E V+N
Sbjct: 1247 NENLGTVKKEWQS-SQRRVSELEKQTDDLRGEIAVLEATVQN 1287
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 63.2 bits (152), Expect = 9e-10
Identities = 74/305 (24%), Positives = 141/305 (46%), Gaps = 50/305 (16%)
Query: 105 EIHRRVEEEEIKR-QRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQ--- 160
+ H+ +E+ I + IE L+NE+ + K+ E + + ++L E +NTQ
Sbjct: 115 DAHKELEQSHINYVKEIENLKNELMAVRSKYSE--------DKANLQKQLEEAMNTQLEL 166
Query: 161 --QLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMK-- 216
QL ED K + E ++++ ++ + L+KQ D + Q++N+++
Sbjct: 167 SEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEAN 226
Query: 217 ---------TFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLN----NRM 263
+ +EEL ++ + E +EL+ + E + + H A E+ LN N +
Sbjct: 227 SQHYQKNINSLQEELLQLKAIHQEEVKELMC----QIEASAKEHEA-EINKLNELKENLV 281
Query: 264 KKVEDYEKQLNRQRIWDCEEYNMIKI--KLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQ 321
K+ E EK N Q+ ++CE N+ K QD QI LQ+ + Q+ EK+++
Sbjct: 282 KQCEASEK--NIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLED 339
Query: 322 VLKKRDEESTVIKSQQKRKINRLHDILNNLRSKY---AKQIK-QFQEENQSLTSDYKRLV 377
LK+ + + +++K + +NNL+ K A+ IK +F E + L L+
Sbjct: 340 TLKELESQHSILKDEV--------TYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELL 391
Query: 378 MQFKE 382
+ +E
Sbjct: 392 LAKEE 396
Score = 55.8 bits (133), Expect = 1e-07
Identities = 150/723 (20%), Positives = 271/723 (37%), Gaps = 122/723 (16%)
Query: 47 LEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREI 106
+E RE +KE E E+ +L L + E N+Q +E
Sbjct: 419 VEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQ-----QEK 473
Query: 107 HRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQ--ELWEMLNTQQLHC 164
+ E R+ +E L+ E+ S K I+ ++E KQ++ EL + L T
Sbjct: 474 QEAILNYESLREIMEILQTELGESAGK---ISQEFESMKQQQASDVHELQQKLRTAFTEK 530
Query: 165 AGLLEDKNKLISE-----LQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFR 219
LLE N+L E QQEL + + +K+L++++ L L + + +K
Sbjct: 531 DALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLK------- 583
Query: 220 EELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNR--QR 277
EL + E+ + + K E+ ++N KK E E+ + ++
Sbjct: 584 -ELEGKINSLTEEKDDFINKLKNSHEE------------MDNFHKKCEREERLILELGKK 630
Query: 278 IWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQ 337
+ +YN +LEQ V L L++ N +KLE + +K E+ V+ +
Sbjct: 631 VEQTIQYNS---ELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA-- 685
Query: 338 KRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDD-- 395
++K EEN L+S+ K+L + L +
Sbjct: 686 --------------------EVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHIT 725
Query: 396 --EKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVG-PISQQPQK 452
EK ++ + ++ L+ + T G FL +G +S+ ++
Sbjct: 726 QLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYG---------FLKEMGSEVSEDSEE 776
Query: 453 ----SATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIE 508
+ Q V E L + EE+ A E L+L K+I K + ++ C+E
Sbjct: 777 KDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEI--KCLQEESVVQCEE------ 828
Query: 509 SKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCS 568
L SLL EQ + L + + + DL ++ N K R + +Q++ S
Sbjct: 829 --LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVS 886
Query: 569 QA--------SMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVI 620
Q EK ++E L EQ E+ + E ++ ++ SP V
Sbjct: 887 QTCSKSEIHNEKEKCFIKEHENLK--PLLEQKELRDRRAELIL-----LKDSLAKSPSVK 939
Query: 621 H-PNDVLKILEAFVMGLKKPRDSR---------APLRVQKNVRDNSKDSEYWQALTTVIP 670
+ P +K LE + L+K + ++ +K + + K+++ + +
Sbjct: 940 NDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLR 999
Query: 671 SSKQNLWDA---LYTALEKYHLVL----TQRAKLLLENSSLEQQNTELQALLQQYLNSKI 723
S K L + L E Y +L Q +L +E ++ L +Q NS +
Sbjct: 1000 SEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTL 1059
Query: 724 NSE 726
E
Sbjct: 1060 QCE 1062
Score = 52.8 bits (125), Expect = 1e-06
Identities = 105/528 (19%), Positives = 217/528 (41%), Gaps = 86/528 (16%)
Query: 117 RQRIEKLENEVKTSQDK-FDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLI 175
+ R +LE E++ + K E T + +R+ L E T+Q C L ++ K+
Sbjct: 45 KSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQ-QCLSLKKENIKMK 103
Query: 176 SELQ----------QELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREEL-YN 224
E++ +EL+ YVK+++ +++ + + E N+ K E +
Sbjct: 104 QEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQ 163
Query: 225 IEKAFEVERQELLASNKKKWEQALQAHN---AKELEYLNNRMKKVEDYEKQLNRQRIWDC 281
+E + +++ Q N KK ++ ++ +++ YL ++ D +K+ Q + +
Sbjct: 164 LELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQ-LQNI 222
Query: 282 EEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKI 341
E N ++++ L+++L Q KAI+Q ++L ++ K E +I
Sbjct: 223 IEAN--SQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHE----------AEI 270
Query: 342 NRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEI 401
N+L+++ NL +KQ + +++ Y+ + + L+KA + D + I
Sbjct: 271 NKLNELKENL-------VKQCEASEKNIQKKYE---CELENLRKATSN--ANQDNQICSI 318
Query: 402 WLMN----EEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQI 457
L E+ + + D + + + H L + ++NN + + + A I
Sbjct: 319 LLQENTFVEQVVNEKVKHLEDTLKELESQHSIL---KDEVTYMNN---LKLKLEMDAQHI 372
Query: 458 VEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLP 517
+E E DL +I+E L+L +E G +IE KL S L
Sbjct: 373 KDEFFHERE---------------DLEFKINE------LLLAKEEQGCVIE-KLKSELAG 410
Query: 518 LEQNECYLL-RLDAIFSALGIESEDDLYKLVNFFLK-YRAHRLSSSLQI----KPCSQAS 571
L + CY + + + +L + + ++ +L FL +L+ +I + C
Sbjct: 411 LNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQ 470
Query: 572 MEK-------ASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEE 612
EK S+ E + EL E ++ ES+ + + + E
Sbjct: 471 QEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHE 518
Score = 48.9 bits (115), Expect = 2e-05
Identities = 71/373 (19%), Positives = 160/373 (42%), Gaps = 50/373 (13%)
Query: 36 IQARRLRIAARLEA---RRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTE 92
+Q + + LEA ++ + + E+ E EE Q + K+K++ + + +L L +
Sbjct: 1092 VQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKD 1151
Query: 93 LVTNIQVAIDIREIHRRVEEEEIK----RQRIEKLENEVKTSQDKFD----EITS----- 139
+ ++I + R ++E K +IE LE E+K + K + EITS
Sbjct: 1152 AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSV 1211
Query: 140 -KWEEGKQKRIPQELW----EMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQY----- 189
++EE K +I Q L E+ +++Q L+ L + L+ EL+ Q
Sbjct: 1212 QQYEE-KNTKIKQLLVKTKKELADSKQAETDHLI-----LQASLKGELEASQQQVEVYKI 1265
Query: 190 -VKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQAL 248
+ ++ + I L+ EQ + + +++ + +++ + E + +
Sbjct: 1266 QLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKV 1325
Query: 249 QAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAI 308
+ HN + + N M + E + R+ + + +KIKL+ L+ + + + +
Sbjct: 1326 RVHNVLK-QQKNKSMSQAETEGAKQEREHLEML--IDQLKIKLQDSQNNLQINVSELQTL 1382
Query: 309 YQLNQEKLEYNLQVLKKR--------------DEESTVIKSQQKRKINRLHDILNNLRSK 354
+ LE + ++L++ E+ ++KS+ + +++L LR+
Sbjct: 1383 QSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNS 1442
Query: 355 YAKQIKQFQEENQ 367
+ Q++ QEE++
Sbjct: 1443 FRDQVRHLQEEHR 1455
>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
Length = 495
Score = 63.2 bits (152), Expect = 9e-10
Identities = 91/405 (22%), Positives = 184/405 (45%), Gaps = 46/405 (11%)
Query: 13 NVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKS 72
NV+ + Q++ +DN +R Q RL + E EA+ + + K+ E
Sbjct: 33 NVNSQIRNQMVQNE--NDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKE----LQ 86
Query: 73 YKQKEESRLKLAKLL---LCGTELVTNIQV-AIDIREIHRRVEEEEIKRQRIEKL--ENE 126
KQ+E+ ++LAKL L ++ ++ +I++RE+ ++++ + ++R ++ ++
Sbjct: 87 LKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDA 146
Query: 127 VKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKD 186
+K Q K D +K + KRI +E + + A D K + E +++ +
Sbjct: 147 IKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAY 206
Query: 187 DQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQ 246
+Q +K+ K D+I + E+Q++ K E N + + E Q+ A +KK +
Sbjct: 207 EQLLKE-KLMIDEIVRKIYE-EDQLEKQQKL---EKMNAMRRYIEEFQKEQALWRKKKRE 261
Query: 247 ALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRK 306
++ N K +E+ N + ++ ED ++ + N + KLE+ ++ E Q R+
Sbjct: 262 EMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQ 321
Query: 307 AIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEEN 366
+YQ +E++ + KS+ K + + + + K++KQ EE
Sbjct: 322 ELYQ----------------EEQAEIYKSKLKEEAEK--------KLRKQKEMKQDFEEQ 357
Query: 367 QSLTSDYKRLVMQ-FKELQKAMRHFALIDDEKFWEIWLMNEEEAK 410
+L K LV+Q KE ++ R L + I LMN ++ +
Sbjct: 358 MAL----KELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQR 398
Score = 52.0 bits (123), Expect = 2e-06
Identities = 67/356 (18%), Positives = 156/356 (43%), Gaps = 61/356 (17%)
Query: 48 EARRREALGEY-LDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREI 106
E +R +A +Y LD +K+ EE + K KQ+ +L KL+ I EI
Sbjct: 177 EDKRNKAKAQYYLDLEKQLEEQEKK--KQEAYEQLLKEKLM---------------IDEI 219
Query: 107 HRRVEEEEI--KRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHC 164
R++ EE+ K+Q++EK+ N ++ ++F + + W + K++ + +E
Sbjct: 220 VRKIYEEDQLEKQQKLEKM-NAMRRYIEEFQKEQALWRKKKREEMEEE------------ 266
Query: 165 AGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICL---LLERMEEQVKNVMKTFREE 221
K+I + + ++D+ K + + + L L +++EE ++ RE+
Sbjct: 267 ------NRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQ-----RED 315
Query: 222 LYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDC 281
L + + E Q + +K K E + KE++ +++ Q ++ +
Sbjct: 316 LEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENF 375
Query: 282 EEYNMIKIKLEQDVQILEQQ------LQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKS 335
+ + K + ++++ Q L+ R+A+ +L +E+ + L ++ EE + +
Sbjct: 376 RKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQR 435
Query: 336 QQ--------KRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKEL 383
+Q + ++ L + NL K + + +++ L +++++ Q E+
Sbjct: 436 RQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKVYQQRSEI 491
Score = 33.1 bits (74), Expect = 0.96
Identities = 68/348 (19%), Positives = 140/348 (40%), Gaps = 75/348 (21%)
Query: 267 EDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKR 326
E+Y K+L+ Q + + + I+ ++ Q+ + ++Q+++ + L E+ E +++ ++
Sbjct: 20 ENYCKKLHVQALKNVN--SQIRNQMVQNEN--DNRVQRKQFLRLLQNEQFELDMEEAIQK 75
Query: 327 DEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKA 386
EE+ +K Q ++ +L L L+ + K K Q+ ++ ++ +EL+K
Sbjct: 76 AEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENS--------IELRELEKK 127
Query: 387 MRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPI 446
++ MN+E A A+ + D I + +
Sbjct: 128 LKAA------------YMNKERA----AQIAEKDAIKYEQ-------------------M 152
Query: 447 SQQPQKSATQIVEEMLMRSEEEEAEEAA--AEPESYLDLPKQISEKTTKRILMLLCDESG 504
+ + + T + E + EE AE+ A+ + YLDL KQ+ E+ K+ +
Sbjct: 153 KRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKK-----QEAYE 207
Query: 505 FLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQI 564
L++ KL+ +D I I ED L K R Q
Sbjct: 208 QLLKEKLM---------------IDEIVRK--IYEEDQLEKQQKLEKMNAMRRYIEEFQK 250
Query: 565 KPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEE 612
+ ++ MEE + + + E M+ ++EE + +E EE+
Sbjct: 251 EQALWRKKKREEMEEENRK----IIEFANMQQQREEDRMAKVQENEEK 294
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,564,131
Number of Sequences: 37866
Number of extensions: 1210268
Number of successful extensions: 13559
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 967
Number of HSP's that attempted gapping in prelim test: 8274
Number of HSP's gapped (non-prelim): 4574
length of query: 740
length of database: 18,247,518
effective HSP length: 110
effective length of query: 630
effective length of database: 14,082,258
effective search space: 8871822540
effective search space used: 8871822540
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.