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Search of human proteins with 217330641
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217330641 IWS1 homolog [Homo sapiens]
(819 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217330641 IWS1 homolog [Homo sapiens] 1628 0.0
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 149 1e-35
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo... 119 1e-26
gi|24415404 MDN1, midasin homolog [Homo sapiens] 103 8e-22
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 100 9e-21
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu... 99 2e-20
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre... 99 2e-20
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 94 5e-19
gi|239753963 PREDICTED: similar to apopolysialoglycoprotein [Hom... 91 3e-18
gi|4504487 histidine rich calcium binding protein precursor [Hom... 89 2e-17
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens] 87 6e-17
gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens] 87 6e-17
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 86 2e-16
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 86 2e-16
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 85 2e-16
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 84 4e-16
gi|58082089 hypothetical protein LOC161394 [Homo sapiens] 82 3e-15
gi|148746195 trichohyalin [Homo sapiens] 80 6e-15
gi|16445033 ACRC protein [Homo sapiens] 80 6e-15
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 80 1e-14
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 80 1e-14
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi... 80 1e-14
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 80 1e-14
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 80 1e-14
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 79 1e-14
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 79 2e-14
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 78 3e-14
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 77 5e-14
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 77 5e-14
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 77 8e-14
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 1628 bits (4216), Expect = 0.0
Identities = 819/819 (100%), Positives = 819/819 (100%)
Query: 1 MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL 60
MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL
Sbjct: 1 MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL 60
Query: 61 PKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS 120
PKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS
Sbjct: 61 PKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS 120
Query: 121 ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP 180
ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP
Sbjct: 121 ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP 180
Query: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE 240
QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE
Sbjct: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE 240
Query: 241 ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS 300
ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS
Sbjct: 241 ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS 300
Query: 301 DSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF 360
DSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF
Sbjct: 301 DSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF 360
Query: 361 HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS 420
HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS
Sbjct: 361 HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS 420
Query: 421 DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGES 480
DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGES
Sbjct: 421 DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGES 480
Query: 481 GDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMS 540
GDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMS
Sbjct: 481 GDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMS 540
Query: 541 GKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKK 600
GKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKK
Sbjct: 541 GKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKK 600
Query: 601 QDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRA 660
QDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRA
Sbjct: 601 QDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRA 660
Query: 661 VMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNS 720
VMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNS
Sbjct: 661 VMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNS 720
Query: 721 TGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQAT 780
TGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQAT
Sbjct: 721 TGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQAT 780
Query: 781 SKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL 819
SKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL
Sbjct: 781 SKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL 819
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 149 bits (375), Expect = 1e-35
Identities = 126/542 (23%), Positives = 216/542 (39%), Gaps = 29/542 (5%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSG------SDTGSVERHSENETSD 55
DS+ D SD T D +G++G DD ++ SG SD+ S + + +++SD
Sbjct: 506 DSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSD 565
Query: 56 REDG-LPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVN 114
D + +DS++ + + ++SDS+S + DS S+ +SDS + +
Sbjct: 566 SSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSD 625
Query: 115 QHGSDSESEET-RKLPGSDSENEELL-NGHASDSENEDVGKHPASDSEIEELQKSPASDS 172
S+S+S ++ K SDS + + N +SDS N +SDS S + S
Sbjct: 626 SSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSS-NSSDSSDSSDSSDSSSSSDSS 684
Query: 173 ETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRH 232
+ D+ S + SE +SDS++ + S+S + S S
Sbjct: 685 NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744
Query: 233 QASDSENEELPKPRISDSESED----PPRHQASDSENEELPKPRISDSESEDPPRNQASD 288
+SDS N S S D +SDS N + S+S D + S
Sbjct: 745 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSS 804
Query: 289 SENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDD-----DSDRENKGEDTE 343
+ ++ SDS+S ++ S++ D+S +S D DSD N+ + +
Sbjct: 805 NSSDSSDSSDSSDSDSSN-SSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSN 863
Query: 344 MQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDE 403
+ S SDS SSDS E + DS + ++ S+S D
Sbjct: 864 SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDS 923
Query: 404 EKA--------SAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEE 455
++ S+ S +D SDS SD S + + +SDS + + SD N
Sbjct: 924 SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSS 983
Query: 456 KDLFGSD-SESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSD 514
SD S+S + ++ + +S D + + + + ++ SDS
Sbjct: 984 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSS 1043
Query: 515 DN 516
D+
Sbjct: 1044 DS 1045
Score = 147 bits (371), Expect = 4e-35
Identities = 118/523 (22%), Positives = 203/523 (38%), Gaps = 26/523 (4%)
Query: 7 SGDQSDDGGATPVQDERDSGSDGEDDVNEQHS-----GSDTGSVERHSENETSDREDGLP 61
S D+S+ + + +S S G+ N S GSD+ E + TSD +
Sbjct: 467 SSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDS 526
Query: 62 KGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSE 121
G+ +++++ + S+S + DS S +SDS++ D N SDS+
Sbjct: 527 NGNGNNGNDDNDKSDSGKGKSDSSD----SDSSDSSNSSDSSDSSDSDSSDSNS-SSDSD 581
Query: 122 SEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQ 181
S ++ SDS++ + N S ++ +SDS + S + ++ K
Sbjct: 582 SSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSD 641
Query: 182 ISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEE 241
SDS S + +SD+ + + S+S + S S S+ +SDS +
Sbjct: 642 SSDSNSSD-----SSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSS 696
Query: 242 LPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSD 301
S+S D +SDS N S+S N + S++ + SD
Sbjct: 697 NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSD--SSNSSD 754
Query: 302 SESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFH 361
S + S++ D+S S D +D N + ++ N S S+S
Sbjct: 755 SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSD 814
Query: 362 SSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSD-ADDS 420
SSDS+ SD + + ++ SDS+ ++ + S SD +D S
Sbjct: 815 SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSS 874
Query: 421 DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSD-------SESGNEEENLI 473
+S SD S E + +SDS + + SD + SD SES N +N
Sbjct: 875 NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSN 934
Query: 474 ADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDN 516
+ S D + + N D + ++ DS+S D+
Sbjct: 935 SSDSSNSSDSSDSSDSS-NSSDSSNSSDSSNSSDSSDSNSSDS 976
Score = 145 bits (366), Expect = 1e-34
Identities = 115/556 (20%), Positives = 210/556 (37%), Gaps = 13/556 (2%)
Query: 7 SGDQSDDGGATPVQDERDSG--SDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGH 64
S D SD ++ D DS SD D + S + S + + + +SD D
Sbjct: 743 SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDS----S 798
Query: 65 HVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEE 124
+ +DS N + ++SDS + DS + S+ +SDS + + GSDS+S
Sbjct: 799 NSSDSSNSSDSS-DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSN 857
Query: 125 TRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDS-ETEDALKPQIS 183
S ++ + ++SDS + ++ S+ + S SDS ++ ++ S
Sbjct: 858 RSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDS 917
Query: 184 DSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELP 243
+ S+ +SD+ N S+S + S + S+ +SDS + +
Sbjct: 918 SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977
Query: 244 KPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSE 303
S S+ +SDS + S+S D + S + ++ SDS
Sbjct: 978 DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSS 1037
Query: 304 SEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSS 363
+ S++ D+S +S D SD + + ++ + S SDS SS
Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSS 1097
Query: 364 DSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSD 423
DS + DS + + + + S + S+ S +D SDS
Sbjct: 1098 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSS 1157
Query: 424 AVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGS--DSESGNEEENLIADIFGESG 481
SD S + + +SDS + + S ++ D S S+S + ++ + +S
Sbjct: 1158 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1217
Query: 482 DEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSG 541
D + + + + E ++ S+S D+ D SD S S
Sbjct: 1218 DSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSN---DESDSQSK 1274
Query: 542 KRRRNRDGGTFISDAD 557
N +G SD++
Sbjct: 1275 SGNGNNNGSDSDSDSE 1290
Score = 143 bits (360), Expect = 7e-34
Identities = 110/515 (21%), Positives = 196/515 (38%), Gaps = 21/515 (4%)
Query: 7 SGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHV 66
S D SD ++ D + S E D ++ S SD+ ++ SD D +
Sbjct: 607 SSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSS 666
Query: 67 TDSENDEPLNLNASDSESEELHRQKDSD----SESEERAEPPASDSENEDVNQHGSDSES 122
S++ + + ++S S SD SES + ++ SDS + + + + S+S
Sbjct: 667 DSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDS 726
Query: 123 EETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASD-SETEDALKPQ 181
+ + SDS N + + S + D S + + S +SD S++ ++
Sbjct: 727 DSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSN 786
Query: 182 ISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEE 241
S + S+ +SDS N S+S+ S + S+ +SDS N
Sbjct: 787 DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSD-------SSNSSDSSNSSDSSDSSNSS 839
Query: 242 LPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSD 301
S+ D SDS N SDS + + + +E+ S
Sbjct: 840 DSSDSSDSSDGSDSDSSNRSDSSNSS-DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSS 898
Query: 302 SESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFH 361
+ S+ ++ S++ D+S ES + SD N + + + S SDS +
Sbjct: 899 NSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN 958
Query: 362 SSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSD 421
SSDS SD + + ++ SDS D S+ S +D SD
Sbjct: 959 SSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSD----SSNSSDSSDSSDSSD 1014
Query: 422 SDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESG 481
S SD S + + +SDS + + S ++ D S+S N ++ + +S
Sbjct: 1015 SSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSD----SSDSSNSSDSSDSSDSSDSS 1070
Query: 482 DEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDN 516
D + + + E + ++ SDS D+
Sbjct: 1071 DSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDS 1105
Score = 142 bits (359), Expect = 1e-33
Identities = 127/531 (23%), Positives = 212/531 (39%), Gaps = 26/531 (4%)
Query: 40 SDTGSVERHSENETSDREDGLPKGHHVTDS-ENDEPLNLNASDSESEELHRQKDSDSESE 98
S+ G+ HS + DG S + D+P N+SD + +SD+ S
Sbjct: 430 SEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDP---NSSDESNGNDDANSESDNNSS 486
Query: 99 ERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHAS----DSENEDVGKH 154
R + + E++D N +GSDS+ E + N NG+ + D++ D GK
Sbjct: 487 SRGDASYNSDESKD-NGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKG 545
Query: 155 PASDSEIEELQKSPASDS----ETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSD 210
+ S+ + S +SDS +++ + SDS+S + +SDS++ + S
Sbjct: 546 KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605
Query: 211 SESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQ-ASDSENEELP 269
S+ SDS + ++ ++ K SDS S D + +SDS N
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665
Query: 270 KPRISDSESEDPPRNQASDSENE-ELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPE 328
S+S D + +SDS N + S + SE +SDS++ D+S
Sbjct: 666 SDSSDSSDSSDS--SSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNS 723
Query: 329 SDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDS-DEDEKEGEEE 387
SD DS + D+ +DS SDS SSDS + + DS D +
Sbjct: 724 SDSDSSNSSDSSDSSNSSDS--SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN 781
Query: 388 KVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKE 447
++ SDS D +S + SD+ DS + SD S + + +SDS + +
Sbjct: 782 SSDSNDSSNSSDSSDSSNSSDSSNS--SDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSS 839
Query: 448 LSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKE 507
S ++ D GSDS+S N ++ + +S D + + + E
Sbjct: 840 DSSDSSDSSD--GSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDS 897
Query: 508 AEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADD 558
+ SDSD + + SD +S + N + SD+ D
Sbjct: 898 SNSSDSDSS--DSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD 946
Score = 142 bits (358), Expect = 1e-33
Identities = 116/525 (22%), Positives = 205/525 (39%), Gaps = 24/525 (4%)
Query: 7 SGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHV 66
S D S+ ++ D DS SD + +S + S + + +E+SD D
Sbjct: 656 SSDSSNSSNSSDSSDSSDS-SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDS---- 710
Query: 67 TDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS-----E 121
S++ + N N+SDS+S DS + S+ +SDS N + SDS
Sbjct: 711 DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSD---SSDSSDSSNSSDSSDSSDSSNSSDS 767
Query: 122 SEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQ 181
S+ + SDS N N ++ S++ D S + + S +SDS++ ++
Sbjct: 768 SDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSS 827
Query: 182 ISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSD-------SESEEPPRHQA 234
S S+ +SDS + S + S+ SD S+S +
Sbjct: 828 NSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNE 887
Query: 235 SDSENEELPKPRISDSESEDPPR-HQASDSEN--EELPKPRISDSESEDPPRNQASDSEN 291
S + ++ SDS+S D +SDS N + SD+ + N + S++
Sbjct: 888 SSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDS 947
Query: 292 EELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHS 351
+ S + S+ +SDS + D+S +S D SD + + ++ N S S
Sbjct: 948 SDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSS 1007
Query: 352 DSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKS 411
DS +SSDS DS + + + + S + + S+ S
Sbjct: 1008 DSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1067
Query: 412 RVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEEN 471
+D SDS S+ S + + +SDS + + S ++ D S S+S N ++
Sbjct: 1068 DSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS-SDSSNSSDS 1126
Query: 472 LIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDN 516
+ +S D + + E + ++ SDS D+
Sbjct: 1127 SDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDS 1171
Score = 141 bits (356), Expect = 2e-33
Identities = 127/536 (23%), Positives = 211/536 (39%), Gaps = 49/536 (9%)
Query: 9 DQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTD 68
D + DG + D++ D + +E + D S S+N +S R D + +D
Sbjct: 444 DSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANS---ESDNNSSSRGDA----SYNSD 496
Query: 69 SENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETR-- 126
D N N SDS+ E D DS+S SD+ N D N +G++ + +
Sbjct: 497 ESKD---NGNGSDSKGAE-----DDDSDS-------TSDTNNSDSNGNGNNGNDDNDKSD 541
Query: 127 ----KLPGSDSENEELLNGH----ASDSENEDVGKHPASDSEIEELQKSPASDSETEDAL 178
K SDS++ + N +SDS++ D + +SDS+ + S +SDS++ D+
Sbjct: 542 SGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD--SNSSSDSDSSDSDSSDSSDSDSSDSS 599
Query: 179 KPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDS-ESEEPPRHQASDS 237
S S+ +SDS + + + S+ K SDS S+ +SDS
Sbjct: 600 NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDS 659
Query: 238 ENEELPKPRISDSESED----PPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEE 293
N S+S D +SDS + S+S D + +SDS +
Sbjct: 660 SNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSS 719
Query: 294 LPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDS 353
SDS + ++ S++ D+S +S D SD N + ++ + S SDS
Sbjct: 720 NSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDS 779
Query: 354 HMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKAS-AKKSR 412
SS+S + DS + + ++ SDS + +S + S
Sbjct: 780 SNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSS 839
Query: 413 VVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENL 472
SD+ DS + SD S + + + +SDS SD + SDS NE N
Sbjct: 840 DSSDSSDSSDGSDSDSSNRSDSSNSSDS--------SDSSDSSNSSDSSDSSDSNESSN- 890
Query: 473 IADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSD 528
+D S + + N D + + E+ +S + N + SD
Sbjct: 891 SSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD 946
Score = 141 bits (356), Expect = 2e-33
Identities = 126/583 (21%), Positives = 214/583 (36%), Gaps = 20/583 (3%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSG--SDGEDDVNEQHSGSDTGSVERHSENETSDREDG 59
DS S S D ++ D DS SD D + +S + S + + +++SD D
Sbjct: 714 DSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDS 773
Query: 60 LPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSD 119
+DS N N +++ S+S + DS + S+ +SDS++ + + +
Sbjct: 774 SDS----SDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS 829
Query: 120 SESEETRKLPGSDSENEELLNGHASDSEN-EDVGKHPASDSEIEELQKSPASDSETEDAL 178
S+S ++ S S++ + +G SDS N D S + S +SDS +
Sbjct: 830 SDSSDSSNSSDS-SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES 888
Query: 179 KPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKP---QVSDSESEEPPRHQAS 235
S+S +SDS N + S+S E S S +S
Sbjct: 889 SNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSS 948
Query: 236 DSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELP 295
DS N S S D +SDS + S+S D + S + ++
Sbjct: 949 DSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD 1008
Query: 296 KPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHM 355
SDS + + S + D+S +S D SD + + + + S SDS
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1068
Query: 356 DRKKFHSSDSEEEEHKKQKMD----SDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKS 411
SSDS + D SD + + ++ SDS D S+ S
Sbjct: 1069 SSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSN-SSDSS 1127
Query: 412 RVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEEN 471
+D SDS SD S E + +SDS + + S ++ D S+S N ++
Sbjct: 1128 DSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSD----SSDSSNSSDS 1183
Query: 472 LIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEM 531
+ +S D + + + + + ++ SDS D+ + D +
Sbjct: 1184 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDS 1243
Query: 532 MLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEED 574
S S + D + +D D S N ++ D
Sbjct: 1244 SDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSD 1286
Score = 140 bits (353), Expect = 5e-33
Identities = 114/527 (21%), Positives = 196/527 (37%), Gaps = 15/527 (2%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLP 61
DS+ D SD + S S D ++ SD+ + S SD D
Sbjct: 579 DSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDS 638
Query: 62 KGHHVTDSENDEPLNLNASDSE-----SEELHRQKDSDSESEERAEPPASDSENEDVNQH 116
K + +D N ++SDS S+ SDS S + + S++ D +
Sbjct: 639 KSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNS 698
Query: 117 GSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETED 176
S+S ++ SDS + N SDS N ++ S+ + S ++ S++ D
Sbjct: 699 SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS-SNSSDSSD 757
Query: 177 ALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASD 236
+ S S+ +SDS N + S+S + S + S+ +SD
Sbjct: 758 SSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSD 817
Query: 237 SENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPK 296
S++ S S+ +SDS + S + S+ + +SDS +
Sbjct: 818 SDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSS 877
Query: 297 PRVSDSES-EGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHM 355
S+S E +SDS S S D SD N + +E N S +S+S
Sbjct: 878 DSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSD 937
Query: 356 DRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKAS-----AKK 410
SSDS + + +S + + ++ S+S D +S +
Sbjct: 938 SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDS 997
Query: 411 SRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEE 470
S + +D SDS SD S + + +SDS + S ++ D SDS ++
Sbjct: 998 SDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSD--SSDSSDSSDSS 1055
Query: 471 NLI-ADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDN 516
N + +S D + + + + E ++ SDS D+
Sbjct: 1056 NSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDS 1102
Score = 140 bits (352), Expect = 6e-33
Identities = 116/530 (21%), Positives = 207/530 (39%), Gaps = 29/530 (5%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSG--SDTGSVERHSENETSDREDG 59
DS+ S D + D DS S + D ++ S SD+ S + + +++SD D
Sbjct: 551 DSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDS 610
Query: 60 LPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSD 119
+DS + ++S SES+ DSDS+S+ + S+N D + +
Sbjct: 611 SDS----SDSSDSSDSKSDSSKSESDS----SDSDSKSDSSDSNSSDSSDNSDSSDSSNS 662
Query: 120 SESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALK 179
S S ++ S + + ++SDS + + + S+ + S +SDS
Sbjct: 663 SNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSN 722
Query: 180 PQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSEN 239
SDS + ++ S++ + S S+ SDS S+ +SDS N
Sbjct: 723 SSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDS-SDSSDSSDSSDSSN 781
Query: 240 EELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRV 299
+ S+S D S + ++ SDS+S N + S + +
Sbjct: 782 SSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSS----NSSDSSNSSDSSDSSN 837
Query: 300 SDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGE--DTEMQNDSFHSDSHMDR 357
S S+ SDS++ + S +S D SD N + D+ N+S +S D
Sbjct: 838 SSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDS 897
Query: 358 KKFHSSDSEEEEHKKQKMD----SDEDEKEGEEEKVAKRKAAVLSDSED-------EEKA 406
SDS + + D SD E + ++ SDS D + +
Sbjct: 898 SNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSS 957
Query: 407 SAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESG 466
++ S SD+ DS+S SD S + + +SDS + + S ++ D S S+S
Sbjct: 958 NSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS-SDSS 1016
Query: 467 NEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDN 516
N ++ + S D + + + + + ++ SDS D+
Sbjct: 1017 NSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1066
Score = 140 bits (352), Expect = 6e-33
Identities = 113/516 (21%), Positives = 204/516 (39%), Gaps = 30/516 (5%)
Query: 3 SEYYSGDQSDDGGATPVQDERDSGSDGED-DVNEQHSGSDTGSVERHSENETSDREDGLP 61
S+ D S+ ++ D DS + + D ++ GSD+ S R + +SD D
Sbjct: 813 SDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSD 872
Query: 62 KGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSE 121
+ +DS + N +++ S+S + DSDS + + S + D ++ + S+
Sbjct: 873 SSNS-SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSD 931
Query: 122 SEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQ 181
+ + S ++ + ++SDS N +SDS S +SDS + D+
Sbjct: 932 NSNSSDSSNSSDSSDSSDSSNSSDSSN-------SSDSS----NSSDSSDSNSSDSSDSS 980
Query: 182 ISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEE 241
S S+ +SDS + S+S + S + S+ +SDS +
Sbjct: 981 NSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSD-- 1038
Query: 242 LPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSD 301
S S+ +SDS N S+S D + S +E SD
Sbjct: 1039 ------SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES------SD 1086
Query: 302 SESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFH 361
S + S++ D+S +S D SD N + ++ + S SDS
Sbjct: 1087 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSD 1146
Query: 362 SSDSEEEEHKKQKMDS-DEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS 420
SS+S + DS D + + ++ SDS D S+ S +D S
Sbjct: 1147 SSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD-SSDSSDSSDSSDSS 1205
Query: 421 DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGES 480
DS SD S + + +SDS + + S ++ D S + S + + + +D +S
Sbjct: 1206 DSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDS 1265
Query: 481 GDEEEEEF-TGFNQEDLEEEKGETQVKEAEDSDSDD 515
DE + + +G + + +++ ++ S SDD
Sbjct: 1266 NDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301
Score = 137 bits (344), Expect = 5e-32
Identities = 107/514 (20%), Positives = 190/514 (36%), Gaps = 11/514 (2%)
Query: 7 SGDQSDDGGATPVQDERDSG----SDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPK 62
S D SD ++ D DS SD D N S SD+ + S++ S
Sbjct: 689 SSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSD 748
Query: 63 GHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSES 122
+ +DS + + ++ S+S + DS + S+ +SDS + N S + S
Sbjct: 749 SSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSS-NSSDSSNSS 807
Query: 123 EETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQI 182
+ + SDS++ + S ++ +SDS S SDS++ +
Sbjct: 808 DSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS----DSSDGSDSDSSNRSDSSN 863
Query: 183 SDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEEL 242
S S+ +SDS + + S+S + SDS S+ +SDS N
Sbjct: 864 SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDS-SDSSNSSDSSDSSNSSD 922
Query: 243 PKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDS 302
+ S++ + S ++ SDS + N + S++ S+S
Sbjct: 923 SSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNS 982
Query: 303 ESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHS 362
+ S++ D+S +S D SD N + + + S SDS S
Sbjct: 983 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDS 1042
Query: 363 SDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDS 422
SDS + +S + + + + S E S+ S +D SDS
Sbjct: 1043 SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDS 1102
Query: 423 DAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGD 482
SD S + + +SDS + S ++ D S S + E + +D +S D
Sbjct: 1103 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSD-SSDSSD 1161
Query: 483 EEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDN 516
+ + + + + ++ SDS D+
Sbjct: 1162 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1195
Score = 136 bits (342), Expect = 9e-32
Identities = 127/540 (23%), Positives = 204/540 (37%), Gaps = 31/540 (5%)
Query: 7 SGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPK-GHH 65
S D SD ++ D +S SD D N S + S + + +++SD D +
Sbjct: 764 SSDSSDSSDSSDSSDSSNS-SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSN 822
Query: 66 VTDSENDEPLNLNASDSESEELHRQKD-SDSESEERAEPP-------ASDSENEDVNQHG 117
+DS N + +++ S+S + D SDS+S R++ +SDS N +
Sbjct: 823 SSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS 882
Query: 118 SDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDA 177
SDS +E + SDS N + +SDS N ++ S+ E S + + ++ +
Sbjct: 883 SDS-NESSNSSDSSDSSNSS--DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSS 939
Query: 178 LKPQISDSE--SEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQAS 235
SDS S +SDS N S S+ SDS +
Sbjct: 940 NSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSD 999
Query: 236 DSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPP-RNQASDSEN--E 292
S + + S S +SDS N S+S D + +SDS N +
Sbjct: 1000 SSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1059
Query: 293 ELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSD 352
SDS + SE+ D+S +S D SD + + ++ + S SD
Sbjct: 1060 SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1119
Query: 353 SHMDRKKFHSSDSEEEEHKKQKMDS-DEDEKEGEEEKVAKRKAAVLSDSEDEEKAS---- 407
S SSDS + DS D E + ++ SDS D +S
Sbjct: 1120 SSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSN 1179
Query: 408 ----AKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEA-GKELSDKKNEEKDLFGSD 462
+ S +D SDS SD S + + +SDS + + + SD + + SD
Sbjct: 1180 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSD 1239
Query: 463 SESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKH 522
S ++ N + +S D + ++ D + + G DSDSD H
Sbjct: 1240 SSDSSDSSN--SSDSSDSSDSSDSTSDSNDESDSQSKSGNGN-NNGSDSDSDSEGSDSNH 1296
Score = 117 bits (293), Expect = 4e-26
Identities = 111/553 (20%), Positives = 201/553 (36%), Gaps = 72/553 (13%)
Query: 4 EYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKG 63
EYY + +D D+ + + E + ++ + E+ E+ + K
Sbjct: 303 EYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKE 362
Query: 64 H--HVTDSENDEPLNLNASDSESEELHRQKDSDSESEE---------------------R 100
H D+ + + S + + ++ +E +E
Sbjct: 363 SETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVN 422
Query: 101 AEPPASDSE----------NEDVNQHGSDSESEETRKLPGSDSENEELLNGH---ASDSE 147
E P SE D N G DS + + + G D + + NG+ S+S+
Sbjct: 423 IEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESD 482
Query: 148 NEDVGKHPASDSEIEELQKSPASDSE-TEDALKPQISD---SESEEPPRHQASDSENEEP 203
N + AS + E SDS+ ED SD S+S + D++ +
Sbjct: 483 NNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDS 542
Query: 204 PKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDS 263
K + S+S+ SDS +SDS++ + SDS+S D +SDS
Sbjct: 543 GKGKSDSSDSDSSDSSNSSDSS-------DSSDSDSSD--SNSSSDSDSSDSDSSDSSDS 593
Query: 264 ENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRH 323
++ + S S+ + +SDS + + + S+ K +SDS + D+S
Sbjct: 594 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS-- 651
Query: 324 KQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKE 383
++ D SD N ++ + S SDS +SSDS + +S +
Sbjct: 652 ----DNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDS 707
Query: 384 GEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEE 443
+ + SDS D +++ S + +D SDS SD S + + +SDS +
Sbjct: 708 SDSDS---------SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758
Query: 444 AGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGET 503
+ S ++ D S S + + N + N D +
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSSNSSDSN--------DSSNSSDSSDSSNSSDSSNSSDSS 810
Query: 504 QVKEAEDSDSDDN 516
++ DSDS ++
Sbjct: 811 DSSDSSDSDSSNS 823
Score = 113 bits (282), Expect = 8e-25
Identities = 115/556 (20%), Positives = 202/556 (36%), Gaps = 64/556 (11%)
Query: 9 DQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTD 68
D SD + DE + G+D+ E +G D+ + + E + +ED +
Sbjct: 240 DNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIG-QN 298
Query: 69 SENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKL 128
S++ E + + E+ K S SE P + S+ + Q + ES+
Sbjct: 299 SDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENR 358
Query: 129 PGSDSENEEL---------LNGHASDSEN------------EDVGKH------------- 154
+SE + + G +S + N ED G+H
Sbjct: 359 ITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQG 418
Query: 155 -------PASDSEI-EELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKP 206
P SE ++ S D D +S + +SD N
Sbjct: 419 EVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDAN 478
Query: 207 RMSDSESEELPKPQVSDSESEE----PPRHQASDSENEELPKPRISDSESEDPPRHQASD 262
SD+ S + ES++ A D +++ SDS + +D
Sbjct: 479 SESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDND 538
Query: 263 SENEELPKPRISDSESEDPPRNQAS--DSENEELPKPRVSDSESEGPQKGPASDSETEDA 320
+ K SDS+S D + S S+++ SDS+S +SDS++ D+
Sbjct: 539 KSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDS 598
Query: 321 SRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDED 380
S +S D SD + + ++ ++DS S+S SSDS+ + SD
Sbjct: 599 SNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSES-------DSSDSDSKSDSSDSNSSDSS 651
Query: 381 EKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDS 440
+ + ++ SDS D +S+ ++ SDS SD S E + +SDS
Sbjct: 652 DNSDSSDSSNSSNSSDSSDSSDSSDSSSSS----DSSNSSDSSDSSDSSNSSESSDSSDS 707
Query: 441 EEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEK 500
+ + SD N SDS+S N ++ + +S D + + + + +
Sbjct: 708 SDSDSSDSSDSSNSN----SSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSN 763
Query: 501 GETQVKEAEDSDSDDN 516
++ SDS D+
Sbjct: 764 SSDSSDSSDSSDSSDS 779
Score = 91.3 bits (225), Expect = 3e-18
Identities = 116/541 (21%), Positives = 209/541 (38%), Gaps = 85/541 (15%)
Query: 12 DDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDG--LPKGHHVTDS 69
D+ GAT S ++G D N Q+ D G H+E+ +EDG + ++ TD+
Sbjct: 144 DNAGAT-----NRSNTNGNTDKNTQNG--DVGDAG-HNEDVAVVQEDGPQVAGSNNSTDN 195
Query: 70 ENDEPLNLNASDSESEELHRQKDSDSESEERAE----------------PPASDSENEDV 113
E++ N ++ + E+ Q +S + AE P+ + +ED
Sbjct: 196 EDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDE 255
Query: 114 NQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSE 173
++ D E EE G DS N ++ E +D GK DS I +S+
Sbjct: 256 DEGSGDDEDEEAGN--GKDSSN------NSKGQEGQDHGKEDDHDSSI-------GQNSD 300
Query: 174 TEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQ 233
+++ P+ + E + S SE P + S+ E +++ ES+
Sbjct: 301 SKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIE-DTQKLNHRESKRVENRI 359
Query: 234 ASDSENEELPKPRISDSESEDP-------PRHQASDSENEE--------LPKPRISDS-- 276
+SE + K + E + P + +E +E L K +
Sbjct: 360 TKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGE 419
Query: 277 --ESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETE-DASRHKQKPESDDDS 333
E P Q S+ N+ SDS S+G D + D + +DD+
Sbjct: 420 VVNIEGP--GQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDA 477
Query: 334 DRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRK 393
+ E+ + + S++SD D S E++ D++ + G
Sbjct: 478 NSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGN------ 531
Query: 394 AAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKN 453
+ ++D +K+ + K + SD+ DSDS SD S + + +SDS+ SD +
Sbjct: 532 ----NGNDDNDKSDSGKGK--SDSSDSDS---SDSSNSSDSSDSSDSDSSDSNSSSDSDS 582
Query: 454 EEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDS 513
+ D SDS + ++ + +S D + + D + K ++ E++ SDS
Sbjct: 583 SDSD--SSDSSDSDSSDSSNSSDSSDSSDSSDSS----DSSDSSDSKSDSSKSESDSSDS 636
Query: 514 D 514
D
Sbjct: 637 D 637
Score = 35.8 bits (81), Expect = 0.17
Identities = 31/142 (21%), Positives = 61/142 (42%), Gaps = 15/142 (10%)
Query: 376 DSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKT 435
D+ +E ++ + A + +++E++ R + + S ++G +E
Sbjct: 169 DAGHNEDVAVVQEDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAE 228
Query: 436 IASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQED 495
+ + E+AG + SD GS S +G +E D SGD+E+EE G ++
Sbjct: 229 VTPGTGEDAGLDNSD---------GSPSGNGADE-----DEDEGSGDDEDEE-AGNGKDS 273
Query: 496 LEEEKGETQVKEAEDSDSDDNI 517
KG+ ++ D D +I
Sbjct: 274 SNNSKGQEGQDHGKEDDHDSSI 295
>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
[Homo sapiens]
Length = 666
Score = 119 bits (297), Expect = 1e-26
Identities = 106/415 (25%), Positives = 177/415 (42%), Gaps = 72/415 (17%)
Query: 76 NLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSEN 135
+L SD++SE + DS S+S+ SD EN + S SES++ + N
Sbjct: 6 DLFGSDADSEAERKDSDSGSDSD-------SDQENAASGSNASGSESDQDERGDSGQPSN 58
Query: 136 EELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQA 195
+EL DSE+E H SD+ E SD+ +E + + D++ + +H
Sbjct: 59 KELFG---DDSEDEGASHHSGSDNHSER------SDNRSEASERSDHEDNDPSDVDQHSG 109
Query: 196 SDSENEEPPKPRMSD--SESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESE 253
S++ N++ + SD S E + + S+ E+ R SD ++E +I +S+ E
Sbjct: 110 SEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDE----KIQNSDDE 165
Query: 254 DPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPAS 313
+ R Q SD + + ++D R Q SD E ++L + ++S+ E P AS
Sbjct: 166 E--RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERP---VAS 220
Query: 314 DSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQ 373
D++ E ++ DD ++ ++ +MQN D + HS D EE++HK +
Sbjct: 221 DNDDE--------KQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSE 272
Query: 374 KMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDAD-DSDSDAVSDKSGKR 432
+A SDSEDE +K+ + SD++ DSD++ D SG
Sbjct: 273 --------------------SARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTM 312
Query: 433 EKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEE 487
+ +D GSD E D G D++EEE
Sbjct: 313 DLFGGADDISS----------------GSDGEDKPPTPGQPVDENGLPQDQQEEE 351
Score = 102 bits (255), Expect = 1e-21
Identities = 94/331 (28%), Positives = 157/331 (47%), Gaps = 52/331 (15%)
Query: 13 DGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRED-GLPKGHHV--TDS 69
D + + + DSGSD + D SGS+ SE++ +R D G P + DS
Sbjct: 11 DADSEAERKDSDSGSDSDSDQENAASGSNASG----SESDQDERGDSGQPSNKELFGDDS 66
Query: 70 ENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLP 129
E++ + + SD+ SE + D+ SE+ ER++ D++ DV+QH
Sbjct: 67 EDEGASHHSGSDNHSE----RSDNRSEASERSD--HEDNDPSDVDQHS------------ 108
Query: 130 GSDSENEELLNGHASD-----SENEDVGKHPASDSEIEELQKSPASDSE----TEDALKP 180
GS++ N++ GH SD SE E K + D + KS SD E ++D +
Sbjct: 109 GSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERA 168
Query: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSE-- 238
Q SD + + ++ +P++SD E ++L + + ++S+ E P D +
Sbjct: 169 QGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQN 228
Query: 239 NEELPKPRISDSE---SEDPPRHQASDSENEELPKPRISDSESEDPPRNQA---SDSENE 292
+++ +P++SD E + D R QASD E+ R SD E E ++++ SDSE+E
Sbjct: 229 SDDEEQPQLSDEEKMQNSDDERPQASDEEH------RHSDDEEEQDHKSESARGSDSEDE 282
Query: 293 ELPKPR----VSDSESEGPQKGPASDSETED 319
L R SDSE++ + P +S T D
Sbjct: 283 VLRMKRKNAIASDSEADSDTEVPKDNSGTMD 313
Score = 94.7 bits (234), Expect = 3e-19
Identities = 117/446 (26%), Positives = 192/446 (43%), Gaps = 68/446 (15%)
Query: 11 SDDGGATPVQDERDS----------GSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL 60
S+ G+ QDER G D ED+ HSGSD S + +E S+R D
Sbjct: 38 SNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSD-- 95
Query: 61 PKGHHVTD-SENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSD 119
H D S+ D+ A + + +E HR SD S +E S+ + D + G +
Sbjct: 96 ---HEDNDPSDVDQHSGSEAPNDDEDEGHR---SDGGS-HHSEAEGSEKAHSDDEKWGRE 148
Query: 120 SESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASD--SETEDA 177
+S++ S++E++ N SD E A S+ ++LQ S + T+D
Sbjct: 149 DKSDQ--------SDDEKIQN---SDDEER------AQGSDEDKLQNSDDDEKMQNTDDE 191
Query: 178 LKPQISDSESEEPPRHQASDSENEEPPKPRMSDSE--SEELPKPQVSDSE---SEEPPRH 232
+PQ+SD E ++ + ++S++E P D + S++ +PQ+SD E + + R
Sbjct: 192 ERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERP 251
Query: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPR----ISDSESEDPPRNQASD 288
QASD E+ D +SE + SDSE+E L R SDSE++ +
Sbjct: 252 QASDEEHRHSDDEEEQDHKSESA---RGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDN 308
Query: 289 SENEEL-----PKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTE 343
S +L SD E + P G D + +++P + + E +T+
Sbjct: 309 SGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTD 368
Query: 344 MQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSD---- 399
+ ND + + F S + + + + D EDE+ +EE + K V +
Sbjct: 369 LGNDLY----FVKLPNFLSVEPRPFDPQYYE-DEFEDEEMLDEEGRTRLKLKVENTIRWR 423
Query: 400 -SEDEEKASAKKS--RVVSDADDSDS 422
DEE K+S R+V +D S S
Sbjct: 424 IRRDEEGNEIKESNARIVKWSDGSMS 449
Score = 83.6 bits (205), Expect = 7e-16
Identities = 78/326 (23%), Positives = 139/326 (42%), Gaps = 49/326 (15%)
Query: 209 SDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEEL 268
SD++SE K S S+S+ + AS S S SES+ R + N+EL
Sbjct: 10 SDADSEAERKDSDSGSDSDSDQENAASGSN--------ASGSESDQDERGDSGQPSNKEL 61
Query: 269 PKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPE 328
DSE E + SD+ +E SD+ SE ++ D++ D +H
Sbjct: 62 FG---DDSEDEGASHHSGSDNHSER------SDNRSEASERSDHEDNDPSDVDQHSGSEA 112
Query: 329 SDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEK 388
+DD D ++ + S HS++ + E+ H +DEK G E+K
Sbjct: 113 PNDDEDEGHRSD-----GGSHHSEA----------EGSEKAHS-------DDEKWGREDK 150
Query: 389 VAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKEL 448
+ + +S+DEE+A + ++DD D + E+ SD E + E
Sbjct: 151 SDQSDDEKIQNSDDEERAQGSDEDKLQNSDD---DEKMQNTDDEERPQLSDDERQQLSEE 207
Query: 449 SDKKNEEKDLFGSDSE-----SGNEEENLIAD--IFGESGDEEEEEFTGFNQEDLEEEKG 501
++++ SD++ S +EE+ ++D S DE + ++ +EE+
Sbjct: 208 EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQ 267
Query: 502 ETQVKEAEDSDSDDNIKRGKHMDFLS 527
+ + + A SDS+D + R K + ++
Sbjct: 268 DHKSESARGSDSEDEVLRMKRKNAIA 293
Score = 60.8 bits (146), Expect = 5e-09
Identities = 125/533 (23%), Positives = 210/533 (39%), Gaps = 90/533 (16%)
Query: 9 DQSDDGGATPVQDE-RDSGSDGE----DDVNEQHSGSDTGSVERHSENET---SDREDGL 60
DQSDD DE R GSD + D +E+ +D + S++E S+ E
Sbjct: 152 DQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKAN 211
Query: 61 PKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS 120
S+ND+ N+ D E +L ++ + +ER P ASD E+ +H D
Sbjct: 212 SDDERPVASDNDDEKQ-NSDDEEQPQLSDEEKMQNSDDER--PQASDEEH----RHSDDE 264
Query: 121 ESEE--TRKLPGSDSENEELL----NGHASDSENEDVGKHPASDSEIEEL---QKSPASD 171
E ++ + GSDSE+E L N ASDSE + + P +S +L +S
Sbjct: 265 EEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSG 324
Query: 172 SETEDALKPQISDSESEEPPRHQASDSENEEP-PK-------PRMSDSESEELPKPQVSD 223
S+ ED KP +E Q D + EEP P+ P+++ +L ++ +
Sbjct: 325 SDGED--KPPTPGQPVDENGLPQ--DQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPN 380
Query: 224 SESEEP----PRHQASDSENEEL----PKPRISDSESEDPPRHQASDSENEELPKPRISD 275
S EP P++ + E+EE+ + R+ D E E+ +
Sbjct: 381 FLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARI 440
Query: 276 SESEDPPRNQASDSENEELPK-PRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDS- 333
+ D + +E ++ K P D ++G + ++ +P S D +
Sbjct: 441 VKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSAT 500
Query: 334 ---------DRENK----------GEDTEMQN-DSFHSDSHMDRKKFHSSDSEEEEHKKQ 373
DR +K G D E Q + + R + +KQ
Sbjct: 501 HRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQ 560
Query: 374 KM----------DSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSD 423
D ++E+EGEE + L+ ++ K ++ R + DSD
Sbjct: 561 HQRGLSASYLEPDRYDEEEEGEE-------SISLAAIKNRYKGGIREERARIYSSDSDEG 613
Query: 424 AVSDKSGK--REKTIASDSE-EEAGK---ELSDKKNEE-KDLFGSDSESGNEE 469
+ DK+ + + K + SD E E +GK E DK N++ K SD E +++
Sbjct: 614 SEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD 666
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 103 bits (256), Expect = 8e-22
Identities = 131/549 (23%), Positives = 217/549 (39%), Gaps = 89/549 (16%)
Query: 14 GGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDR-------EDGLPKGHHV 66
G P + DS +G + ++ G G E + SD+ ED KG
Sbjct: 4653 GFCLPKEFMEDSAGEGATEFHDYEGG---GIGEGEGMKDVSDQIGNEEQVEDTFQKGQEK 4709
Query: 67 TDSENDEPLNLNASDS--ESEELHRQKDSDSESEERAEPPA-SDSENEDVNQHGSDSESE 123
+ D ++ D+ E E K D E EE+ E SDSE D+++H D E
Sbjct: 4710 DKEDPDSKSDIKGEDNAIEMSEDFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGE 4769
Query: 124 ETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQIS 183
E KL +E L G D E ED E EE D++TE+ P +
Sbjct: 4770 EADKL-------DERLWG--DDDEEED---------EEEE-------DNKTEET-GPGMD 4803
Query: 184 DSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELP 243
+ +SE + DS N K + E +E E+E Q D NE++
Sbjct: 4804 EEDSELVAKDDNLDSGNSNKDKSQQDKKEEKE---------EAEADDGGQGEDKINEQID 4854
Query: 244 KPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSE 303
+ ++E + +Q E E L P + +SED +N D++NEE + + +
Sbjct: 4855 ERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSED--KNGGEDTDNEEGEEENPLEIK 4912
Query: 304 SEGPQKGPASDS--ETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFH 361
+ + G ++ ETE Q P+ ++ E+ + E + D+ D D +
Sbjct: 4913 EKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHP 4972
Query: 362 SSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSD 421
SEE++ ++ D + DE+ GE + E+EE+ + V +A +
Sbjct: 4973 EEHSEEQQQSVEEKDKEADEEGGENGPADQG----FQPQEEEEREDSDTEEQVPEALERK 5028
Query: 422 SDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNE----EENLIADIF 477
A ++G E + + E AG + +K + K+ GS + N+ E N IA +
Sbjct: 5029 EHASCGQTGV-ENMQNTQAMELAG--AAPEKEQGKEEHGSGAADANQAEGHESNFIAQLA 5085
Query: 478 GES-------------GDEEEEEFTGFNQE-----------DLEEEKGETQVKEA--EDS 511
+ G + E G + E D E+G Q +A ED+
Sbjct: 5086 SQKHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDA 5145
Query: 512 DSDDNIKRG 520
D+ ++IK+G
Sbjct: 5146 DAFEHIKQG 5154
Score = 82.4 bits (202), Expect = 2e-15
Identities = 103/502 (20%), Positives = 201/502 (40%), Gaps = 69/502 (13%)
Query: 18 PVQDERDSGSDGEDD-VNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLN 76
P DE DS +DD ++ +S D ++ E E ++ +DG + ++ +N
Sbjct: 4800 PGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDG---------GQGEDKIN 4850
Query: 77 LNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENE 136
+ + +E + D ++E+ P + +D+N D K G D++NE
Sbjct: 4851 EQIDERDYDE--NEVDPYHGNQEKVPEPEALDLPDDLNLDSED-------KNGGEDTDNE 4901
Query: 137 ELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQAS 196
E + EN +E +K + E E+ + + +ES+ P +
Sbjct: 4902 E------GEEEN-----------PLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEG 4944
Query: 197 DSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSE-SEDP 255
SE+++ D+ +++ D ++ + P + + + K + +D E E+
Sbjct: 4945 PSEDDKAEGEEEMDTGADD------QDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENG 4998
Query: 256 PRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDS 315
P Q + EE E ED SD+E E++P+ + Q G +
Sbjct: 4999 PADQGFQPQEEE---------ERED------SDTE-EQVPEALERKEHASCGQTGVENMQ 5042
Query: 316 ETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKM 375
T+ PE + + G Q + S+ + + K++
Sbjct: 5043 NTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPG 5102
Query: 376 DSDEDEKEGE-EEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDS-DAVSDKSGKRE 433
+D + G+ E+V KR V +DS E+ + + V DAD + SD +
Sbjct: 5103 QADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQT 5162
Query: 434 KTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFT---G 490
+AS ++++ K+ S K EE+++ + ++ +EE AD+ +E + T G
Sbjct: 5163 YDVASKEQQQSAKD-SGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPEEIKSGTTAPLG 5221
Query: 491 FNQEDLEEEKGETQVKEAEDSD 512
F++ ++E + VK ED D
Sbjct: 5222 FDEMEVEIQ----TVKTEEDQD 5239
Score = 67.0 bits (162), Expect = 7e-11
Identities = 114/524 (21%), Positives = 196/524 (37%), Gaps = 78/524 (14%)
Query: 2 DSEYYSGDQSDDGGATPVQDER-----DSGSDGEDDVNEQHSGSDT---------GSVER 47
D SG+ + D ++E+ D G GED +NEQ D G+ E+
Sbjct: 4813 DDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDERDYDENEVDPYHGNQEK 4872
Query: 48 HSENETSDREDGL------PKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERA 101
E E D D L G TD+E E ++ E + +++ E+EER
Sbjct: 4873 VPEPEALDLPDDLNLDSEDKNGGEDTDNEEGE------EENPLEIKEKPEEAGHEAEERG 4926
Query: 102 EPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEI 161
E +E++ Q + SE+ + +E EE ++ A D + D +HP SE
Sbjct: 4927 ETETDQNESQSP-QEPEEGPSEDDK------AEGEEEMDTGADDQDG-DAAQHPEEHSE- 4977
Query: 162 EELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQV 221
E+ Q D E ++ E P Q + EE DS++EE +
Sbjct: 4978 EQQQSVEEKDKEADE--------EGGENGPADQGFQPQEEE----EREDSDTEEQVPEAL 5025
Query: 222 SDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDP 281
E + + +N + + + E E S + + + S+ ++
Sbjct: 5026 ERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLA 5085
Query: 282 PRNQASDSENEELPKPRVSDSE-SEGPQK----------GPASDSETEDASRHKQKPESD 330
+ + KP +D+E S G S +E A + + + E
Sbjct: 5086 SQKHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDA 5145
Query: 331 DDSDRENKGEDT-EMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDE-------K 382
D + +G D + Q S K D EEEE + MD++E E +
Sbjct: 5146 DAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVE 5205
Query: 383 EGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSD--ADDSDSDAVSDKSGK-REKTIASD 439
+ + E++ A L E E + K+ D D + + ++K + RE TI +
Sbjct: 5206 QLKPEEIKSGTTAPLGFDEMEVEIQTVKTEEDQDPRTDKAHKETENEKPERSRESTIHTA 5265
Query: 440 SE-------EEAGKELSDKKNE-EKDL-FGSDSESGNEEENLIA 474
+ + K++++ + E E+ L ESGN EE +A
Sbjct: 5266 HQFLMDTIFQPFLKDVNELRQELERQLEMWQPRESGNPEEEKVA 5309
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 99.8 bits (247), Expect = 9e-21
Identities = 115/552 (20%), Positives = 213/552 (38%), Gaps = 103/552 (18%)
Query: 3 SEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPK 62
+E++ ++ + G + E + +GE ++ E+ E E +RE G K
Sbjct: 666 AEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDG----EEQEQKEREQGHQK 721
Query: 63 GHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSES 122
+ E E + + E EE R+++ + E E + E + E E + G +
Sbjct: 722 ERNQEMEEGGEEEH---GEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKE 778
Query: 123 EETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIE--ELQKSPASDSETEDALKP 180
E K + E ++ G + E E G+ E+E E+++ E E+ +
Sbjct: 779 ERAGKEEKGEEEGDQ---GEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEG 835
Query: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE 240
+ + E EE + E EE + E EE E EE + + E E
Sbjct: 836 EEEEGEGEE------EEGEGEEEEGEGKGEEEGEE--------GEGEE--EGEEGEGEGE 879
Query: 241 ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS 300
E + E E + + E EE + + E E + + E E
Sbjct: 880 EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEG------E 933
Query: 301 DSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF 360
+ E EG + + E E+ ++ E + + + E +GE E + +
Sbjct: 934 EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG------------ 981
Query: 361 HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS 420
EEEE + + +E+E E E E+ + + + E+EE+ +
Sbjct: 982 -----EEEEGEGE---GEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVE----------- 1022
Query: 421 DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGES 480
V + G+ E EEE G+E +++ +E + G ++ EEE + E+
Sbjct: 1023 --GEVEGEEGEGE------GEEEEGEEEGEEREKEGE--GEENRRNREEEEEEEGKYQET 1072
Query: 481 GDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSM- 539
G+EE E ++D EE K +++K ++K GKH + +KKS+
Sbjct: 1073 GEEENE------RQDGEEYKKVSKIK--------GSVKYGKHKTY---------QKKSVT 1109
Query: 540 ----SGKRRRNR 547
+GK +R++
Sbjct: 1110 NTQGNGKEQRSK 1121
Score = 97.8 bits (242), Expect = 4e-20
Identities = 111/508 (21%), Positives = 199/508 (39%), Gaps = 47/508 (9%)
Query: 27 SDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASD-SESE 85
SD E ++ E+ G++ E E E+ + H E E L+ + +D +E
Sbjct: 580 SDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKV--HGGRKEKTEILSDDLTDKAEVS 637
Query: 86 ELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASD 145
E + ++E + E +H D E E+ K G E E G
Sbjct: 638 EGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGR-GEMERPGEGEKEL 696
Query: 146 SENEDVGKHPASDSEIEELQKSPASD--SETEDALKPQISDSESEEPPRHQASDSENEEP 203
+E E+ K + E +E ++ + E E+ + + + E EE R + + E E
Sbjct: 697 AEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGK 756
Query: 204 PKPR----MSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQ 259
+ + E EE + + + EE + E EE ++E + +
Sbjct: 757 EEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE------EETEGRGEEKEE 810
Query: 260 ASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETED 319
+ E E+ + + E E+ + + E EE E EG KG E E
Sbjct: 811 GGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEE---EEGEGEEEEGEGKGEEEGEEGEG 867
Query: 320 ASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHK-KQKMDSD 378
++ ++ + E +GE+ E + + + + ++ + EEEE + K + + +
Sbjct: 868 EEEGEEGEGEGEEEEGEGEGEE-EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE 926
Query: 379 EDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIAS 438
E E EGEEE+ + E+EE + ++ + + + G+ E+
Sbjct: 927 EGEGEGEEEEGEGEGEDGEGEGEEEE------GEWEGEEEEGEGEGEEEGEGEGEEGEGE 980
Query: 439 DSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEE----------EEF 488
EEE E +++ EE+ G + G EE GE G+EEE EE
Sbjct: 981 GEEEEGEGEGEEEEGEEE---GEEEGEGEEEGE------GE-GEEEEEGEVEGEVEGEEG 1030
Query: 489 TGFNQEDLEEEKGETQVKEAEDSDSDDN 516
G +E+ EE+GE + KE E ++ N
Sbjct: 1031 EGEGEEEEGEEEGEEREKEGEGEENRRN 1058
Score = 94.4 bits (233), Expect = 4e-19
Identities = 115/560 (20%), Positives = 209/560 (37%), Gaps = 45/560 (8%)
Query: 17 TPVQDERDSGSDGE---DDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDS--EN 71
+PVQ ++ + GE D ++ SD E S+ ++G HV+
Sbjct: 518 SPVQKQKKQQTIGELTQDTALTENDDSD-------EYEEMSEMKEGKACKQHVSQGIFMT 570
Query: 72 DEPLNLNASDSESEELHRQKDSDSESEERA-EPPASDSENEDVNQHGSDSESEETRKLPG 130
+ A E E+ +K+ +S+ E ++ E+V HG E+T L
Sbjct: 571 QPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGG--RKEKTEILSD 628
Query: 131 SDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPA--SDSETEDALKPQISDSESE 188
++ E+ G A + G D EE D E E K + E E
Sbjct: 629 DLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDK-GRGEME 687
Query: 189 EPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRIS 248
P + +E EE K + E +E + + E + E EE R
Sbjct: 688 RPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREE 747
Query: 249 DSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQ 308
+ E E + + E E + + + E+ + E + + ++E G +
Sbjct: 748 EEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEE 807
Query: 309 K---GPASDSETEDASRHKQKPESDDDSDREN-KGEDTEMQNDSFHSDSHMDRKKFHSSD 364
K G E E+ +++ E + + + E +GE+ E + + + + +
Sbjct: 808 KEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEG 867
Query: 365 SEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDA 424
EE E + + + +E E EGEEE + + + E EE+ + + +
Sbjct: 868 EEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEE-GEGEGEEEGEGEGEEEEGEGKGEEEGE 926
Query: 425 VSDKSGKREKTIAS------DSEEEAGK------ELSDKKNEEKDLFGSDSESGNEEENL 472
+ G+ E+ + EEE G+ E + EE + G + E EEE
Sbjct: 927 EGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEE- 985
Query: 473 IADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIK----RGKHMDFLSD 528
GE EEEE +E EE+GE + +E E+ + + ++ G+ + +
Sbjct: 986 -----GEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGE 1040
Query: 529 FEMMLQRKKSMSGKRRRNRD 548
E + K+ + RRNR+
Sbjct: 1041 EEGEEREKEGEGEENRRNRE 1060
Score = 38.9 bits (89), Expect = 0.020
Identities = 30/161 (18%), Positives = 59/161 (36%), Gaps = 17/161 (10%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLP 61
+ E G+ ++ G ++E + +GE + E+ G G VE + E+G
Sbjct: 982 EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE 1041
Query: 62 KGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSE 121
+G + E EE R ++ + E E + + E+ N+ E
Sbjct: 1042 EGEE------------REKEGEGEENRRNREEEEEEEGKYQ-----ETGEEENERQDGEE 1084
Query: 122 SEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIE 162
++ K+ GS + S + + GK S ++
Sbjct: 1085 YKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQ 1125
>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
precursor [Homo sapiens]
Length = 513
Score = 98.6 bits (244), Expect = 2e-20
Identities = 106/433 (24%), Positives = 171/433 (39%), Gaps = 42/433 (9%)
Query: 8 GDQSDDGGATPVQDERDSGSD--GEDDVNEQHSGSDTGSVERHSENETSD-----REDGL 60
GD DD DE DSG D G+DD G R +E SD E+
Sbjct: 99 GDDKDD-------DEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESA 151
Query: 61 PKGHHVTDSENDEPLNLNASDS-ESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSD 119
P+G E L+ D +S+ +SESEE SD E+ HG
Sbjct: 152 PQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESS----HGDG 207
Query: 120 SESEETRKLPGSDSENEELLNGHASDSENEDVG---KHPASDSEIEELQKSPASDSETED 176
SE ++ G S++ E + +S G K +SE Q S S
Sbjct: 208 SELDDE----GMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP 263
Query: 177 ALKPQISDSESEEPPRHQASDSENEEPPKP---RMSDSESEELPKPQV-SDSESEEPPRH 232
+ K SEE R + D+ E K S+S L +P+ S +S+E +
Sbjct: 264 SRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKE 323
Query: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSE-- 290
S E++ + P S+ + + S EE+ S ++ DP + D E
Sbjct: 324 NLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSE--SRGDNPDPTTSYVEDQEDS 381
Query: 291 --NEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDS 348
+EE +S S+SE ++ S+S +E + ++ PES +D EN +Q+ S
Sbjct: 382 DSSEEDSSHTLSHSKSESREEQADSES-SESLNFSEESPESPED---ENSSSQEGLQSHS 437
Query: 349 FHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASA 408
++S + DS+ ++ + K DS+ E + E+ + K + + A
Sbjct: 438 SSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESR--KLTVDA 495
Query: 409 KKSRVVSDADDSD 421
++ + D DD+D
Sbjct: 496 YHNKPIGDQDDND 508
Score = 82.4 bits (202), Expect = 2e-15
Identities = 115/496 (23%), Positives = 181/496 (36%), Gaps = 64/496 (12%)
Query: 45 VERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPP 104
V R+ NE+ D E+ KGH PL SES E S SEE+A
Sbjct: 19 VTRYQNNESEDSEEW--KGHLA--QAPTPPLE----SSESSE-----GSKVSSEEQANED 65
Query: 105 ASDSENEDVNQHGSDSE---------SEETRKLPGSDSENEELLNGHASDSENEDVGKHP 155
SDS + D + S T K G D +++E +G D D P
Sbjct: 66 PSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGK-GGDDKDDDEDDSG---DDTFGDDDSGP 121
Query: 156 ASDSEIEELQKSPASDSETEDALK------PQISDSESEEPPRHQASDSENEEPPKPRMS 209
E SD +++D ++ PQ DS + + D+E+ KP
Sbjct: 122 GPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGG 181
Query: 210 DSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDS--ESEDPP--RHQASDSE- 264
DS E SESEE SD E+ + D +S+DP R + +S
Sbjct: 182 DSTQE---------SESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRM 232
Query: 265 NEELPKPRISDSESEDPPRNQASDSENEELP------KPRVS--DSESEGPQKGPASDSE 316
N K + S SE + S+ E P K R+S D SE + +
Sbjct: 233 NSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVK 292
Query: 317 TEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMD 376
++ + R++KG+ E ++ S SS+S +E + + +
Sbjct: 293 SDSTENSNSRDTGLSQPRRDSKGDSQEDSKENL-SQEESQNVDGPSSESSQEANLSSQEN 351
Query: 377 SDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTI 436
S E ++E E S ED+E SD+ + DS S +
Sbjct: 352 SSESQEEVVSESRGDNPDPTTSYVEDQED---------SDSSEEDSSHTLSHSKSESREE 402
Query: 437 ASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDL 496
+DSE S++ E + S S+ G + + A+ E EE++ +
Sbjct: 403 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRS 462
Query: 497 EEEKGETQVKEAEDSD 512
+E+ T+ K + + D
Sbjct: 463 KEDSNSTESKSSSEED 478
Score = 66.2 bits (160), Expect = 1e-10
Identities = 85/380 (22%), Positives = 148/380 (38%), Gaps = 38/380 (10%)
Query: 161 IEELQKSPASDSET-----EDALKPQISDSESEEPPRHQASDSENEEPPKPRMSD----S 211
+ Q + + DSE A P + SES E + + + NE+P S+ S
Sbjct: 19 VTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGS 78
Query: 212 ESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKP 271
+ + D + ++ D +S P+ + + N L
Sbjct: 79 DDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDR-QEGGNSRLGSD 137
Query: 272 RISD----SESEDPPRNQAS----DSENEELPKPRVSDSESEGPQKGPASDSE------- 316
SD + E P+ Q S SE+ EL DS+ EG S+SE
Sbjct: 138 EDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGG 197
Query: 317 TEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMD 376
++ S H E DD+ + + E S +S M+ S +S E + D
Sbjct: 198 SDGESSHGDGSELDDEGMQSDDPESIR----SERGNSRMNSAGMKSKESGENSEQANTQD 253
Query: 377 SDEDE-KEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKT 435
S + E K+ ++ D E + V SD+ ++ + + S R +
Sbjct: 254 SGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDS 313
Query: 436 IASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQED 495
DS+E++ + LS ++++ D G SES ++E NL + E+ E +EE ++ D
Sbjct: 314 -KGDSQEDSKENLSQEESQNVD--GPSSES-SQEANLSSQ---ENSSESQEEVVSESRGD 366
Query: 496 LEEEKGETQVKEAEDSDSDD 515
+ + V++ EDSDS +
Sbjct: 367 -NPDPTTSYVEDQEDSDSSE 385
Score = 54.3 bits (129), Expect = 4e-07
Identities = 74/325 (22%), Positives = 118/325 (36%), Gaps = 45/325 (13%)
Query: 231 RHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSE 290
R+Q ++SE+ E K ++ + + PP + SE ++ SE+ SDS
Sbjct: 21 RYQNNESEDSEEWKGHLAQAPT--PPLESSESSEGSKV--------SSEEQANEDPSDST 70
Query: 291 NEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFH 350
E E G SR K D D D ++ G+DT +DS
Sbjct: 71 QSE---------EGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGP 121
Query: 351 SDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKK 410
D +E + + D D D+ E+ A + D+ E + +
Sbjct: 122 G----------PKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNE 171
Query: 411 SRVVSDADDSDSDAVSDKSGKREKTIASDSEEEA----GKELSDKKNEEKDLFGSDSESG 466
RV S + DS + +S E + S+ E+ G EL D+ + D SE G
Sbjct: 172 DRVDSKPEGGDS---TQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERG 228
Query: 467 NEEENLIADIFGESGDEEEEEFT-GFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDF 525
N N ESG+ E+ T L E +++ S+ DD +
Sbjct: 229 NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSE------- 281
Query: 526 LSDFEMMLQRKKSMSGKRRRNRDGG 550
D ++ KS S + +RD G
Sbjct: 282 -LDDNNTMEEVKSDSTENSNSRDTG 305
Score = 52.4 bits (124), Expect = 2e-06
Identities = 64/292 (21%), Positives = 114/292 (39%), Gaps = 64/292 (21%)
Query: 242 LPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSD 301
LP R ++ESED + ++ P P + SES + + + + NE+
Sbjct: 17 LPVTRYQNNESEDSEEWKGHLAQ---APTPPLESSESSEGSKVSSEEQANED-------P 66
Query: 302 SESEGPQKGPASDSE------TEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHM 355
S+S ++G SD SR K D D D ++ G+DT +DS
Sbjct: 67 SDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDS------- 119
Query: 356 DRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVS 415
+ +E ++ SDED S+D +AS + +
Sbjct: 120 -----GPGPKDRQEGGNSRLGSDED-------------------SDDTIQASEESA---P 152
Query: 416 DADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDL-FGSDSESGNEEENLIA 474
DS D S+ S + + DS+ E G + ++EE + GSD ES +
Sbjct: 153 QGQDSAQDTTSE-SRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSH------- 204
Query: 475 DIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEA--EDSDSDDNIKRGKHMD 524
G+ + ++E + E + E+G +++ A + +S +N ++ D
Sbjct: 205 ---GDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 253
>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
precursor [Homo sapiens]
Length = 497
Score = 98.6 bits (244), Expect = 2e-20
Identities = 106/433 (24%), Positives = 171/433 (39%), Gaps = 42/433 (9%)
Query: 8 GDQSDDGGATPVQDERDSGSD--GEDDVNEQHSGSDTGSVERHSENETSD-----REDGL 60
GD DD DE DSG D G+DD G R +E SD E+
Sbjct: 83 GDDKDD-------DEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESA 135
Query: 61 PKGHHVTDSENDEPLNLNASDS-ESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSD 119
P+G E L+ D +S+ +SESEE SD E+ HG
Sbjct: 136 PQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESS----HGDG 191
Query: 120 SESEETRKLPGSDSENEELLNGHASDSENEDVG---KHPASDSEIEELQKSPASDSETED 176
SE ++ G S++ E + +S G K +SE Q S S
Sbjct: 192 SELDDE----GMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP 247
Query: 177 ALKPQISDSESEEPPRHQASDSENEEPPKP---RMSDSESEELPKPQV-SDSESEEPPRH 232
+ K SEE R + D+ E K S+S L +P+ S +S+E +
Sbjct: 248 SRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKE 307
Query: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSE-- 290
S E++ + P S+ + + S EE+ S ++ DP + D E
Sbjct: 308 NLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSE--SRGDNPDPTTSYVEDQEDS 365
Query: 291 --NEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDS 348
+EE +S S+SE ++ S+S +E + ++ PES +D EN +Q+ S
Sbjct: 366 DSSEEDSSHTLSHSKSESREEQADSES-SESLNFSEESPESPED---ENSSSQEGLQSHS 421
Query: 349 FHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASA 408
++S + DS+ ++ + K DS+ E + E+ + K + + A
Sbjct: 422 SSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESR--KLTVDA 479
Query: 409 KKSRVVSDADDSD 421
++ + D DD+D
Sbjct: 480 YHNKPIGDQDDND 492
Score = 80.1 bits (196), Expect = 8e-15
Identities = 111/490 (22%), Positives = 186/490 (37%), Gaps = 68/490 (13%)
Query: 45 VERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDS-ESEE---------LHRQKDSD 94
V R+ NE+ D E+ KGH + + N + SDS +SEE ++R
Sbjct: 19 VTRYQNNESEDSEEW--KGH-LAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGF 75
Query: 95 SESEERAEPPASDSENEDVNQHGSDSES--------EETRKLPGSDSENEELLNGHASDS 146
S S + D E++ + D +S E GSD ++++ + +
Sbjct: 76 SRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ---ASE 132
Query: 147 ENEDVGKHPASD--SEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPP 204
E+ G+ A D SE EL DS+ E Q +SESEE SD E+
Sbjct: 133 ESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQ--ESESEEHWVGGGSDGES---- 186
Query: 205 KPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSE 264
S + EL + + E + + N K + S SE + S+
Sbjct: 187 ----SHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQ 242
Query: 265 NEELPKPRISDSE--SEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASR 322
E P +I SE+ R++ D+ E K SDS +S + D
Sbjct: 243 LLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVK---SDS---------TENSNSRDTGL 290
Query: 323 HKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEK 382
+ + +S DS ++K +N S ++D SS+S +E + + +S E ++
Sbjct: 291 SQPRRDSKGDSQEDSK------ENLSQEESQNVDGP---SSESSQEANLSSQENSSESQE 341
Query: 383 EGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEE 442
E E S ED+E SD+ + DS S + +DSE
Sbjct: 342 EVVSESRGDNPDPTTSYVEDQED---------SDSSEEDSSHTLSHSKSESREEQADSES 392
Query: 443 EAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGE 502
S++ E + S S+ G + + A+ E EE++ + +E+
Sbjct: 393 SESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNS 452
Query: 503 TQVKEAEDSD 512
T+ K + + D
Sbjct: 453 TESKSSSEED 462
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 94.0 bits (232), Expect = 5e-19
Identities = 100/477 (20%), Positives = 196/477 (41%), Gaps = 34/477 (7%)
Query: 28 DGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEEL 87
+G+ +E +GS+ G E+ E + E G H + + + + +S+
Sbjct: 1773 EGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGA 1832
Query: 88 HRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSE 147
+ ++E E + E SE + + D++ E P S+ G A E
Sbjct: 1833 EGIEAPEAEGEAQPE-----SEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQP-E 1886
Query: 148 NEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPR 207
+EDV + P ++ E++ + A E E +P+ E+ E +SE E +
Sbjct: 1887 SEDV-ETPEAEWEVQP-ESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE 1944
Query: 208 MSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEE 267
+ E+E +P+ ES+E +SE+ E + + E+E + ++ D E E
Sbjct: 1945 EAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPE 2004
Query: 268 LPKPRISDSESEDPPRNQASD----SENEELPKPRVSDSESEGPQKGPASDSETEDASRH 323
+ + ++E E P + + SE EE + ++EG + + E +A
Sbjct: 2005 -AEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEE 2063
Query: 324 KQKPESD-DDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEK 382
Q+ E + +++ E E ++ ++ + + + ++E E K + +++ E E
Sbjct: 2064 AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEG 2123
Query: 383 EGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEE 442
E + E + E E +A + V +A D++ +A + G A ++EE
Sbjct: 2124 EAQPESEG------IEAPEAEGEAQPESEGV--EAQDAEGEAQPESEGIE----AQEAEE 2171
Query: 443 EAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEE 499
EA EL + E ++ E+ E E + A E+ E + E G + EEE
Sbjct: 2172 EAQPELEGVEAPE-----AEGEAQPESEGIEAP---EAEGEAQPELEGVEAPEAEEE 2220
Score = 86.7 bits (213), Expect = 8e-17
Identities = 113/541 (20%), Positives = 207/541 (38%), Gaps = 61/541 (11%)
Query: 19 VQDERDSGSDGED-DVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNL 77
+Q +R +DGE +V + +D S R + GL +G V + E+ E
Sbjct: 1693 LQRKRGEHTDGEAAEVAPGKTHTDPTST-RTVQGAEGGLGPGLSQGPGVDEGEDGEG--- 1748
Query: 78 NASDSESEELHRQKD---SDSESEERAEPPASDSENEDVNQHGSDSESE-------ETRK 127
S+ L+R KD ++E + A+ + N + + E+E E +
Sbjct: 1749 ------SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGE 1802
Query: 128 LPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSES 187
G S +E+ L G A+ ++D G+ ++ IE + + E+E P+
Sbjct: 1803 TGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEG-IEAPEAEGEAQPESEGVEAPEAEGDAQ 1861
Query: 188 EEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPR- 246
E Q + E P + ESE++ P+ E +A ++E E P+
Sbjct: 1862 EAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETES 1921
Query: 247 --ISDSESEDPPRHQASDSENEE--------LPKPRISDSESEDPPRNQASDSENEELPK 296
++E ED P + ++++ E +P ES++ +SE+ E +
Sbjct: 1922 VEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALE 1981
Query: 297 PRVSDSESEGPQKGPASDSETEDASRHKQK------PESDD-DSDRENKGEDT---EMQN 346
V E+EG + + D E +A Q+ PESD ++ +++GE+ E +
Sbjct: 1982 VEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGET 2041
Query: 347 DSFHSDSHMDRKKFHSSDSEEE-------------EHKKQKMDSDEDEKEGEEEKVAKRK 393
D+ + + ++EEE E + D D E EGE + ++
Sbjct: 2042 QKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGV 2101
Query: 394 AAVLSDSEDEEKASAKKSRVVSDADDSDS-----DAVSDKSGKREKTIASDSEEEAGKEL 448
A ++ E ++ + +A +A + + E A D+E EA E
Sbjct: 2102 EAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPES 2161
Query: 449 SDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEA 508
+ +E + G E + ES E E G Q +LE + +EA
Sbjct: 2162 EGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEA 2221
Query: 509 E 509
+
Sbjct: 2222 Q 2222
Score = 84.0 bits (206), Expect = 5e-16
Identities = 112/514 (21%), Positives = 211/514 (41%), Gaps = 58/514 (11%)
Query: 7 SGDQSDDGGATPVQDERDSG-SDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHH 65
SG + + G ++D G SDG + + +E E +G+
Sbjct: 1808 SGHEDNLQGEAAAGGDQDPGQSDGAEGIEAP-----------EAEGEAQPESEGV----E 1852
Query: 66 VTDSENDEPLNLNASDSESEELHRQKDSDS-ESEERAEPPASDSENE----DVNQHGSDS 120
++E D A ++E E +D ++ E+E A+P + D E +V +
Sbjct: 1853 APEAEGD------AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGA 1906
Query: 121 ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP 180
E+ E K ++E+ E L ++E ED +SE E Q++ + E E +P
Sbjct: 1907 EAPEAEKEAQPETESVEAL-----ETEGED-----EPESEGAEAQEAEEAAQEAEGQTQP 1956
Query: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE 240
+ ES+E +SE+ E + + E+E +P +SE E P + E E
Sbjct: 1957 ESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQP---ESEDVEAPEAEGEMQEAE 2013
Query: 241 ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS 300
E +P E++ P+ + +++ E + + +A ++E EE +
Sbjct: 2014 EEAQPESDGVEAQ--PKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE-EEAQEAEGE 2070
Query: 301 DSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF 360
E+EG + D + ++A Q PES+ E +GE + + + +
Sbjct: 2071 VQEAEGEAHPESEDVDAQEAEGEAQ-PESEGVEAPEAEGEAQKAEGIEAPETEGEAQPES 2129
Query: 361 HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS 420
++ E E + Q + ++ E E A+ ++ + E EE+A + V +A ++
Sbjct: 2130 EGIEAPEAEGEAQPESEGVEAQDAEGE--AQPESEGIEAQEAEEEAQPELEGV--EAPEA 2185
Query: 421 DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENL-IADIFGE 479
+ +A + G A ++E EA EL + E ++ E+ E E + + GE
Sbjct: 2186 EGEAQPESEGIE----APEAEGEAQPELEGVEAPE-----AEEEAQPEPEGVETPEAEGE 2236
Query: 480 SGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDS 513
+ E E E G + + G+ Q +EA +S S
Sbjct: 2237 AQPESEGETQGEKKGSPQVSLGDGQSEEASESSS 2270
Score = 72.8 bits (177), Expect = 1e-12
Identities = 94/445 (21%), Positives = 172/445 (38%), Gaps = 53/445 (11%)
Query: 20 QDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNA 79
Q+ + +DV +T E ++ E+ D E +G E +P +
Sbjct: 1964 QEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGV 2023
Query: 80 S---DSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESE----ETRKLPGSD 132
SE EE + ++E A+P + E + + ++E E E P S+
Sbjct: 2024 EAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESE 2083
Query: 133 SENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETE---DALKPQISDSESEE 189
+ + G A E+E V + P ++ E ++ + A ++E E ++ + ++E E
Sbjct: 2084 DVDAQEAEGEAQP-ESEGV-EAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEA 2141
Query: 190 PPRHQ---ASDSENEEPPKPR-MSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKP 245
P + A D+E E P+ + E+EE +P++ E+ E +SE E P
Sbjct: 2142 QPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAP-- 2199
Query: 246 RISDSESEDPPRHQ---ASDSENEELPKP---RISDSESEDPPRNQASDSENEELPKPRV 299
++E E P + A ++E E P+P ++E E P ++ +++ E+ P+V
Sbjct: 2200 ---EAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESE-GETQGEKKGSPQV 2255
Query: 300 SDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDT----------------E 343
S + + + +S ED R P D+ + G T +
Sbjct: 2256 SLGDGQSEEASESSSPVPED--RPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKD 2313
Query: 344 MQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSD---- 399
+ND D+ K S+ + E K +M + E EE + R +
Sbjct: 2314 SENDHVLGDTRSPDAK--STGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYD 2371
Query: 400 -SEDEEKASAKKSRVVSDADDSDSD 423
ED+ S + V AD D
Sbjct: 2372 LQEDQALGSLAPTEAVGRADGFGQD 2396
Score = 50.1 bits (118), Expect = 8e-06
Identities = 115/564 (20%), Positives = 202/564 (35%), Gaps = 77/564 (13%)
Query: 8 GDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVT 67
G Q ++ +++ G E E+ G ++ + E +E+GLP+ V
Sbjct: 1348 GQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGL-KEEGLPEEGSVH 1406
Query: 68 DSENDEPLNLNASDSESEELHRQKDSDSES-----------EERAEPPASDSENE-DVNQ 115
E E + + S+ ++ +++++ S EE EPP+ SE + ++
Sbjct: 1407 GQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASE 1466
Query: 116 HGSDSESEE-TRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDS-- 172
S S+ E K PG+ +E H + + +S + L P S
Sbjct: 1467 RQSGSQLEPGLEKPPGATMMGQE----HTQAQPTQGAAERSSSVACSAALDCDPIWVSVL 1522
Query: 173 --ETEDALKPQISDSESEEPPRHQASD--------SENEEPPKPRMSDSESEELPKPQVS 222
+TE A ++ + +E R D +E ++ R+ DS EL K Q
Sbjct: 1523 LKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGR 1582
Query: 223 DSESE-EPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPR------ISD 275
EPPR E L + ++ RH+ N R +S
Sbjct: 1583 AGRMVLEPPR--------EALTGELLLQTQQR---RHRLRGLRNLSAFSERTLGLGPLSF 1631
Query: 276 SESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDR 335
+ ++P + A S+ E E+EG + P E R K P S +
Sbjct: 1632 TLEDEPALSTALGSQLGE---------EAEGEEFCPC-----EACVRKKVSPMSPKATMG 1677
Query: 336 ENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEK---EGEEEKVAKR 392
+G E +F + RK+ +D E E K +D +G E +
Sbjct: 1678 ATRGPIKE----AFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPG 1733
Query: 393 KAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKK 452
+ DE + R+ D D +A D + + +SE AG EL + +
Sbjct: 1734 LSQ--GPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE 1791
Query: 453 NEEKDLF--GSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVK---- 506
E + + G G+ E+ + GD++ + G + E +GE Q +
Sbjct: 1792 QEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGV 1851
Query: 507 EAEDSDSDDNIKRGKHMDFLSDFE 530
EA +++ D G+ D E
Sbjct: 1852 EAPEAEGDAQEAEGEAQPESEDVE 1875
>gi|239753963 PREDICTED: similar to apopolysialoglycoprotein [Homo
sapiens]
Length = 538
Score = 91.3 bits (225), Expect = 3e-18
Identities = 74/347 (21%), Positives = 157/347 (45%), Gaps = 8/347 (2%)
Query: 82 SESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNG 141
SE+ + D+ SE+ +R P + SE +H +D+ SE ++ +D+ +E +
Sbjct: 2 SEAVQRRHPADTMSEAVQRRHPADTMSEAAQ-RRHPADTTSEAAQRRHPADTTSEPVQRR 60
Query: 142 HASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENE 201
H +D+ +E + +D+ E +Q+ +D+ +E A + +D+ SE R +D+ +E
Sbjct: 61 HPADTMSEAAQRRHPADTMSEAVQRRHPADTMSEAAQRRHPADTMSEAVQRRHPADTMSE 120
Query: 202 EPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQAS 261
+ +D+ SE + +D+ SE R +D+ +E + + +D+ SE R +
Sbjct: 121 AAQRRHPADTMSEAAQRRHPADTMSEAVQRRHPADTMSEAVQRRDPADTMSEAVQRRHPA 180
Query: 262 DSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDAS 321
D+ +E + +D+ SE R +D+ +E + +D+ SE Q+ +D+ +E A
Sbjct: 181 DTMSEAAQRRHPADTMSEAAQRRDPADTMSEAAQRRDPADTISEAAQRRDPADTMSEAAQ 240
Query: 322 RHKQKPESDDDSDRENKGE---DTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSD 378
R + + R + + + + D + S +++ + E ++ D+
Sbjct: 241 RRHPADTMSEAAQRRDPADTISEAAQRRDPADTMSEAAQRRDPADTISEAAQRRDPADTM 300
Query: 379 EDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAV 425
+ + +AA D D +A++ D D+ S+AV
Sbjct: 301 SEAAQRRHPADTMSEAAQRRDPADTMSEAAQR----RDPADTMSEAV 343
>gi|4504487 histidine rich calcium binding protein precursor [Homo
sapiens]
Length = 699
Score = 89.0 bits (219), Expect = 2e-17
Identities = 120/536 (22%), Positives = 191/536 (35%), Gaps = 85/536 (15%)
Query: 24 DSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHV----TDSENDEPLNLNA 79
D G GE+ V +H G G H + + D ED HH+ + S DE +
Sbjct: 115 DEGVSGEE-VFAEHGGQARG----HRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVV 169
Query: 80 SDSESEEL--HRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDS-ENE 136
S + H + D E +E E + E E+ + S + + G S E+E
Sbjct: 170 SSEHHHHILRHGHRGHDGEDDEGEE----EEEEEEEEEEASTEYGHQAHRHRGHGSEEDE 225
Query: 137 ELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQ-- 194
++ +GH + H D + D + +D +S + RHQ
Sbjct: 226 DVSDGHHHHGPSHRHQGHEEDDDD---------DDDDDDDDDDDDVSIEYRHQAHRHQGH 276
Query: 195 -------ASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRI 247
SD + P R E ++ VS + RHQ D EE+
Sbjct: 277 GIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQ--DHRKEEVEAVSG 334
Query: 248 SDSESEDPPRHQA--SDSENEELPKPR------------ISDSESEDPPRNQASDSENEE 293
RHQ + E+E++ R + + E E+ Q
Sbjct: 335 EHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASH 394
Query: 294 LPKPRVSDSE-------SEGP----QKGPASDSETEDASRHKQKP-----ESDDDSDREN 337
P+ SD E +E P + P + E A Q P D+++
Sbjct: 395 QPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQ 454
Query: 338 KGEDTEMQNDSFHSDSH---MDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEE--EKVAKR 392
+G EM S H H DR DSEEE+ K++ S E++ E E EK
Sbjct: 455 RGSIKEM---SHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHH 511
Query: 393 KAAVLSDSEDEEKA-SAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDK 451
+ D EDEE+ ++ + +D + + + +RE+ E G LS
Sbjct: 512 GSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREE------RAEVGAPLSPD 565
Query: 452 KNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKE 507
+EE++ + E G EE+ I D EE ++E+ E+ G +E
Sbjct: 566 HSEEEE----EEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQE 617
Score = 86.7 bits (213), Expect = 8e-17
Identities = 112/524 (21%), Positives = 191/524 (36%), Gaps = 64/524 (12%)
Query: 28 DGEDDVNEQHSGSDTGSVERHSENETSDREDG-LPKGHHVTDSE-------NDEPLNLNA 79
D DV+ ++ +R E+E +E G L GH D + +E +
Sbjct: 69 DENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHG 128
Query: 80 SDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELL 139
+ H +D++ +E R P+ S H E E+ ++ S+ + L
Sbjct: 129 GQARGHRGHGSEDTEDSAEHRHHLPSHRS-------HSHQDEDED--EVVSSEHHHHILR 179
Query: 140 NGHASDSENEDVGKHPASDSEIEE---------LQKSPASDSETEDALKPQISDSESEEP 190
+GH +D G+ + E EE + SE ++ +SD
Sbjct: 180 HGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDE----DVSDGHHHHG 235
Query: 191 PRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDS 250
P H+ E ++ D + ++ VS + RHQ E +E +SD
Sbjct: 236 PSHRHQGHEEDDDDDDDDDDDDDDD----DVSIEYRHQAHRHQGHGIEEDE----DVSDG 287
Query: 251 ESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKG 310
P H+ E ++ +S R+Q E E + +G
Sbjct: 288 HHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQG 347
Query: 311 PASDSETEDAS--RHKQKPESDDDS--DRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSE 366
+ E ED S R Q P+ D E + E+ +Q + + SH R H SD E
Sbjct: 348 HRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVA-SHQPRG--HKSDEE 404
Query: 367 EEE---------HKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDA 417
+ + H ++ +EDE+ E + + + +DEE ++ + +
Sbjct: 405 DFQDEYKTEVPHHHHHRVPREEDEEVSAE--LGHQAPSHRQSHQDEETGHGQRGSIKEMS 462
Query: 418 DDSDSDAV-SDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADI 476
V D+S R+ DSEEE KE +EE D E G + +
Sbjct: 463 HHPPGHTVVKDRSHLRK----DDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQE- 517
Query: 477 FGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRG 520
+ DEEE NQE+ EEE E + +E ++ ++ + G
Sbjct: 518 --DEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVG 559
Score = 79.3 bits (194), Expect = 1e-14
Identities = 94/456 (20%), Positives = 167/456 (36%), Gaps = 78/456 (17%)
Query: 3 SEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPK 62
S + G + DD D+ D D +DDV+ ++ RH + + ED +
Sbjct: 237 SHRHQGHEEDDD-----DDDDDDDDDDDDDVSIEYRHQ----AHRHQGHGIEEDED-VSD 286
Query: 63 GHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSES 122
GHH D S H + D+D + S ++H D
Sbjct: 287 GHHHRDP------------SHRHRSHEEDDNDDDD-------VSTEYGHQAHRH-QDHRK 326
Query: 123 EETRKLPGSDSEN--EELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP 180
EE + G + + GH + E+EDV + + + E E+ +
Sbjct: 327 EEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGP-QHVHHGLVDEEEEEEEITV 385
Query: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE 240
Q + PR SD E+ D E+P H+ E+E
Sbjct: 386 QFGHYVASHQPRGHKSDEED-------FQDEYKTEVPHHH----------HHRVPREEDE 428
Query: 241 ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS 300
E +S P H+ S + E R S E P + L K
Sbjct: 429 E-----VSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRK---D 480
Query: 301 DSESEGP-QKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKK 359
DSE E ++ P S E +++S +K D+E++ ++ E S + +
Sbjct: 481 DSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEE------ 534
Query: 360 FHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADD 419
EEEE K+++ + +++E+ E +V + S+ E+EE+ ++ D+
Sbjct: 535 ------EEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEE-------DE 581
Query: 420 SDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEE 455
+ + +RE+ + SEEE+G++ + +E
Sbjct: 582 PRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQE 617
>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 87.0 bits (214), Expect = 6e-17
Identities = 85/327 (25%), Positives = 141/327 (43%), Gaps = 32/327 (9%)
Query: 219 PQVSDSESEEPPRHQASDSENEELPKPRISDSES--EDPPRHQASDSENEELPKPRISDS 276
P S ++E A + +E + D E + A +S E+ + +
Sbjct: 406 PSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEK 465
Query: 277 ESED--PPRN-QASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDS 333
ESE+ P R + S S+ E V SE + P+K + D + ES+DD
Sbjct: 466 ESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDL 525
Query: 334 DRENK---GEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVA 390
++E++ G E + D +S D + S D E E ++ ++ D DE EG E+++
Sbjct: 526 NKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDE-EGSEKELH 584
Query: 391 KR---KAAVLSDSEDEEKASAKKSRVVSDAD-----DSDSDAVSDKSGKREKTIASDSEE 442
+ K +DSE+ E +V+ + D DSD ++ EK +S+E
Sbjct: 585 ENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDE 644
Query: 443 EAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEE---- 498
+ +E +D+K E +E G+ +E L F ES D+E+E+ G ED +E
Sbjct: 645 KEDEEYADEKGLEAA--DKKAEEGDADEKL----FEESDDKEDEDADGKEVEDADEKLFE 698
Query: 499 --EKGETQVKEAEDSDS---DDNIKRG 520
+ E E EDS DD+ +RG
Sbjct: 699 DDDSNEKLFDEEEDSSEKLFDDSDERG 725
Score = 85.9 bits (211), Expect = 1e-16
Identities = 76/336 (22%), Positives = 135/336 (40%), Gaps = 36/336 (10%)
Query: 21 DERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPK--------------GHHV 66
++ + G + E+ +E ++ + E + E+G PK G+ V
Sbjct: 432 EKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPV 491
Query: 67 TDSENDEPLNLN-----ASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSE 121
SE D P + +D E L ++ + D E E + ED ++ SD +
Sbjct: 492 RGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDED 551
Query: 122 SEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQ 181
E + GS+ E EE NG D + E K + +EL+++ + +SE ED +
Sbjct: 552 CSEKQSEDGSEREFEE--NGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEK 609
Query: 182 ISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEE 241
+ D E E + SD + E EE +V D ES+E + +D + E
Sbjct: 610 VLDEEGSEREFDEDSD------------EKEEEEDTYEKVFDDESDEKEDEEYADEKGLE 657
Query: 242 LPKPRISDSESEDPPRHQASDSENEELPKPRISDSES---EDPPRNQASDSENEELPKPR 298
+ + ++++ ++ D E+E+ + D++ ED N+ E E+ +
Sbjct: 658 AADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKL 717
Query: 299 VSDSESEGPQKGPASDSETEDASRHKQKPESDDDSD 334
DS+ G G S E ++ SDDD D
Sbjct: 718 FDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDD 753
Score = 79.0 bits (193), Expect = 2e-14
Identities = 99/406 (24%), Positives = 165/406 (40%), Gaps = 42/406 (10%)
Query: 123 EETRKLPGSDSENEELLNGHASDSENEDVGKHPA-SDSEIEELQKSPASDSETEDALKPQ 181
E R L SDS + + A S +HP+ S +E A + ++ +
Sbjct: 377 EANRGLRRSDSVSA---SERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEK 433
Query: 182 ISDS-ESEE-PPRHQASDSENEEPPKPRMSDSESEE-LPKP----QVSDSESEE--PPRH 232
D E EE + A +S E+ + + ESEE PK S ESEE P R
Sbjct: 434 TEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRG 493
Query: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENE 292
DS +E K + + E+ ++ D N+E + ESE+ + SD +
Sbjct: 494 SEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCS 553
Query: 293 ELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHS- 351
E K SE E + G D + E + + + D + + EN E++E ++D
Sbjct: 554 E--KQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELE-ENDSENSEFEDDGSEKV 610
Query: 352 --DSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAK 409
+ +R+ SD +EEE + D++ E E+E+ A K +D + EE
Sbjct: 611 LDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEE----- 665
Query: 410 KSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEE 469
DAD+ + DK + E+ GKE+ D + + S+ + +EE
Sbjct: 666 -----GDADEKLFEESDDK----------EDEDADGKEVEDADEKLFEDDDSNEKLFDEE 710
Query: 470 ENLIADIFGESGDEEEEEFTGFNQ-EDLEEEKGETQVKEAEDSDSD 514
E+ +F +S +E GF E+ G + + ++D D D
Sbjct: 711 EDSSEKLFDDS--DERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/197 (23%), Positives = 88/197 (44%), Gaps = 25/197 (12%)
Query: 9 DQSDDGGATPVQDERDSGSDGEDDVNEQHS--GSDT----GSVERHSENETSDRE---DG 59
+ ++ G T +E DS + ++D +E+ S GS+ +E+ + E S++E +
Sbjct: 528 ESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENV 587
Query: 60 LPKGHHVTDSENDE--------PLNLNASDSESEELHRQKDSDSESEERAEPPASDSENE 111
L K DSEN E L+ S+ E +E +K+ + ++ E+ SD E E
Sbjct: 588 LDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESD-EKE 646
Query: 112 DVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASD 171
D + +D + E + + +E L + D E+ED A E+E+ + D
Sbjct: 647 D--EEYADEKGLEAADKKAEEGDADEKLFEESDDKEDED-----ADGKEVEDADEKLFED 699
Query: 172 SETEDALKPQISDSESE 188
++ + L + DS +
Sbjct: 700 DDSNEKLFDEEEDSSEK 716
Score = 44.3 bits (103), Expect = 5e-04
Identities = 41/149 (27%), Positives = 70/149 (46%), Gaps = 12/149 (8%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRED--- 58
DSE + + DDG V DE S + ++D +E+ DT E+ ++E+ ++ED
Sbjct: 596 DSE--NSEFEDDGSEK-VLDEEGSEREFDEDSDEKEEEEDT--YEKVFDDESDEKEDEEY 650
Query: 59 GLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGS 118
KG D + +E +A + EE ++D D++ +E + E++D N+
Sbjct: 651 ADEKGLEAADKKAEEG---DADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLF 707
Query: 119 DSESEETRKLPGSDSENEELLNGHASDSE 147
D E + + KL DS+ L G S E
Sbjct: 708 DEEEDSSEKL-FDDSDERGTLGGFGSVEE 735
>gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 87.0 bits (214), Expect = 6e-17
Identities = 85/327 (25%), Positives = 141/327 (43%), Gaps = 32/327 (9%)
Query: 219 PQVSDSESEEPPRHQASDSENEELPKPRISDSES--EDPPRHQASDSENEELPKPRISDS 276
P S ++E A + +E + D E + A +S E+ + +
Sbjct: 406 PSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEK 465
Query: 277 ESED--PPRN-QASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDS 333
ESE+ P R + S S+ E V SE + P+K + D + ES+DD
Sbjct: 466 ESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDL 525
Query: 334 DRENK---GEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVA 390
++E++ G E + D +S D + S D E E ++ ++ D DE EG E+++
Sbjct: 526 NKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDE-EGSEKELH 584
Query: 391 KR---KAAVLSDSEDEEKASAKKSRVVSDAD-----DSDSDAVSDKSGKREKTIASDSEE 442
+ K +DSE+ E +V+ + D DSD ++ EK +S+E
Sbjct: 585 ENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDE 644
Query: 443 EAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEE---- 498
+ +E +D+K E +E G+ +E L F ES D+E+E+ G ED +E
Sbjct: 645 KEDEEYADEKGLEAA--DKKAEEGDADEKL----FEESDDKEDEDADGKEVEDADEKLFE 698
Query: 499 --EKGETQVKEAEDSDS---DDNIKRG 520
+ E E EDS DD+ +RG
Sbjct: 699 DDDSNEKLFDEEEDSSEKLFDDSDERG 725
Score = 85.9 bits (211), Expect = 1e-16
Identities = 76/336 (22%), Positives = 135/336 (40%), Gaps = 36/336 (10%)
Query: 21 DERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPK--------------GHHV 66
++ + G + E+ +E ++ + E + E+G PK G+ V
Sbjct: 432 EKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPV 491
Query: 67 TDSENDEPLNLN-----ASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSE 121
SE D P + +D E L ++ + D E E + ED ++ SD +
Sbjct: 492 RGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDED 551
Query: 122 SEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQ 181
E + GS+ E EE NG D + E K + +EL+++ + +SE ED +
Sbjct: 552 CSEKQSEDGSEREFEE--NGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEK 609
Query: 182 ISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEE 241
+ D E E + SD + E EE +V D ES+E + +D + E
Sbjct: 610 VLDEEGSEREFDEDSD------------EKEEEEDTYEKVFDDESDEKEDEEYADEKGLE 657
Query: 242 LPKPRISDSESEDPPRHQASDSENEELPKPRISDSES---EDPPRNQASDSENEELPKPR 298
+ + ++++ ++ D E+E+ + D++ ED N+ E E+ +
Sbjct: 658 AADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKL 717
Query: 299 VSDSESEGPQKGPASDSETEDASRHKQKPESDDDSD 334
DS+ G G S E ++ SDDD D
Sbjct: 718 FDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDD 753
Score = 79.0 bits (193), Expect = 2e-14
Identities = 99/406 (24%), Positives = 165/406 (40%), Gaps = 42/406 (10%)
Query: 123 EETRKLPGSDSENEELLNGHASDSENEDVGKHPA-SDSEIEELQKSPASDSETEDALKPQ 181
E R L SDS + + A S +HP+ S +E A + ++ +
Sbjct: 377 EANRGLRRSDSVSA---SERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEK 433
Query: 182 ISDS-ESEE-PPRHQASDSENEEPPKPRMSDSESEE-LPKP----QVSDSESEE--PPRH 232
D E EE + A +S E+ + + ESEE PK S ESEE P R
Sbjct: 434 TEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRG 493
Query: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENE 292
DS +E K + + E+ ++ D N+E + ESE+ + SD +
Sbjct: 494 SEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCS 553
Query: 293 ELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHS- 351
E K SE E + G D + E + + + D + + EN E++E ++D
Sbjct: 554 E--KQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELE-ENDSENSEFEDDGSEKV 610
Query: 352 --DSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAK 409
+ +R+ SD +EEE + D++ E E+E+ A K +D + EE
Sbjct: 611 LDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEE----- 665
Query: 410 KSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEE 469
DAD+ + DK + E+ GKE+ D + + S+ + +EE
Sbjct: 666 -----GDADEKLFEESDDK----------EDEDADGKEVEDADEKLFEDDDSNEKLFDEE 710
Query: 470 ENLIADIFGESGDEEEEEFTGFNQ-EDLEEEKGETQVKEAEDSDSD 514
E+ +F +S +E GF E+ G + + ++D D D
Sbjct: 711 EDSSEKLFDDS--DERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/197 (23%), Positives = 88/197 (44%), Gaps = 25/197 (12%)
Query: 9 DQSDDGGATPVQDERDSGSDGEDDVNEQHS--GSDT----GSVERHSENETSDRE---DG 59
+ ++ G T +E DS + ++D +E+ S GS+ +E+ + E S++E +
Sbjct: 528 ESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENV 587
Query: 60 LPKGHHVTDSENDE--------PLNLNASDSESEELHRQKDSDSESEERAEPPASDSENE 111
L K DSEN E L+ S+ E +E +K+ + ++ E+ SD E E
Sbjct: 588 LDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESD-EKE 646
Query: 112 DVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASD 171
D + +D + E + + +E L + D E+ED A E+E+ + D
Sbjct: 647 D--EEYADEKGLEAADKKAEEGDADEKLFEESDDKEDED-----ADGKEVEDADEKLFED 699
Query: 172 SETEDALKPQISDSESE 188
++ + L + DS +
Sbjct: 700 DDSNEKLFDEEEDSSEK 716
Score = 44.3 bits (103), Expect = 5e-04
Identities = 41/149 (27%), Positives = 70/149 (46%), Gaps = 12/149 (8%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRED--- 58
DSE + + DDG V DE S + ++D +E+ DT E+ ++E+ ++ED
Sbjct: 596 DSE--NSEFEDDGSEK-VLDEEGSEREFDEDSDEKEEEEDT--YEKVFDDESDEKEDEEY 650
Query: 59 GLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGS 118
KG D + +E +A + EE ++D D++ +E + E++D N+
Sbjct: 651 ADEKGLEAADKKAEEG---DADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLF 707
Query: 119 DSESEETRKLPGSDSENEELLNGHASDSE 147
D E + + KL DS+ L G S E
Sbjct: 708 DEEEDSSEKL-FDDSDERGTLGGFGSVEE 735
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 85.5 bits (210), Expect = 2e-16
Identities = 126/589 (21%), Positives = 228/589 (38%), Gaps = 95/589 (16%)
Query: 4 EYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETS------DRE 57
++ DQSD+ T D++ S E+ +E+ E+ + +RE
Sbjct: 929 KFLKKDQSDE---TSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPERE 985
Query: 58 D--GLPKG-----HHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSEN 110
+ PKG + TD E + + + +EL SD + + + DS
Sbjct: 986 EICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDEL-----SDYAEKSTGKGDSCDSSE 1040
Query: 111 EDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSE-----IEELQ 165
+ +++G+ ++ KL G S + + +SD+E + + + S+ IE +
Sbjct: 1041 DKKSKNGAYGREKKRCKLLGKSSRKRQ--DCSSSDTEKYSMKEDGCNSSDKRLKRIELRE 1098
Query: 166 KSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSE 225
+ S ++ S S++EE SE+ + K R S + + K + +S
Sbjct: 1099 RRNLSSKRNTKEIQSGSSSSDAEE-------SSEDNKKKKQRTSSKKKAVIVKEKKRNSL 1151
Query: 226 SEEPPRHQA-----SDSENEELPKPRISDSESEDPPRHQASD-------------SENEE 267
R QA S S+ E+ + I + S++ ++ S +E
Sbjct: 1152 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEA 1211
Query: 268 LPKP---RISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHK 324
L K + D + ++ P N+ + E K +S E +SD E E+ +
Sbjct: 1212 LSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDG------SSDDEPEEGKKRT 1265
Query: 325 QKPESDDDSDRENKGE-DTEMQNDSFHSDS-----HMDRKKFHSSDSEEEEHKKQKMDSD 378
K ++ D E K + ++E +DS S + R K SD E E KK K
Sbjct: 1266 GKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTK---- 1321
Query: 379 EDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIAS 438
KE +E K R+ DSED + + S VS+++D +S K+ +
Sbjct: 1322 --PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRT--RSAKKAEL--- 1374
Query: 439 DSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEE 498
EE + KK + DS S N+ + +EEEEE +E+ EE
Sbjct: 1375 ---EENQRSYKQKKKRRRIKVQEDSSSENKSNS----------EEEEEEK---EEEEEEE 1418
Query: 499 EKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNR 547
E+ E + ++ D R K L D ++ + + ++ + R +
Sbjct: 1419 EEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRK 1467
Score = 81.3 bits (199), Expect = 3e-15
Identities = 116/554 (20%), Positives = 217/554 (39%), Gaps = 72/554 (12%)
Query: 19 VQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNL- 77
++ + +S SDG + + E+ + +N T+D E K T + DE +
Sbjct: 967 MEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYA 1026
Query: 78 -----------NASDSESE------ELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS 120
++ D +S+ E R K S +R + +SD+E + + G +S
Sbjct: 1027 EKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNS 1086
Query: 121 ESEETRKLPGSDSEN-------EELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSE 173
+ +++ + N +E+ +G +S E SE + +K S +
Sbjct: 1087 SDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES--------SEDNKKKKQRTSSKK 1138
Query: 174 TEDALKPQISDSESEEPPRHQA-----SDSENEEPPKPRMSDSESEELPKPQVSDSE--S 226
+K + +S R QA S S+ E+ + + + S+E V+++ S
Sbjct: 1139 KAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLS 1198
Query: 227 EEPPRHQASDSE--NEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSE--SEDPP 282
Q+S E ++ +P D + DP A EE+ SD + S+D P
Sbjct: 1199 SHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEP 1258
Query: 283 RN--QASDSENEELPKPRVSDSESEGPQKGPASDSETEDAS----RHKQKPESDDDSDRE 336
+ + +NEE P D E++ Q SDS++E++ RH+ SD E
Sbjct: 1259 EEGKKRTGKQNEENP----GDEEAKN-QVNSESDSDSEESKKPRYRHRLLRHKLTVSDGE 1313
Query: 337 NKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEE-KVAKRKAA 395
+ GE+ + + +R+K S DSE+ + ++ + + E E E+ + K A
Sbjct: 1314 S-GEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKA 1372
Query: 396 VLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEE 455
L +++ K K+ R+ D S + + + + EK + EEE +E D+ ++
Sbjct: 1373 ELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDS 1432
Query: 456 K---------------DLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEK 500
K D +++++ +EE E E E+ ED K
Sbjct: 1433 KSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTK 1492
Query: 501 GETQVKEAEDSDSD 514
K D D +
Sbjct: 1493 CPITTKLVLDEDEE 1506
Score = 75.1 bits (183), Expect = 2e-13
Identities = 106/468 (22%), Positives = 175/468 (37%), Gaps = 77/468 (16%)
Query: 2 DSEYYS----GDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRE 57
D+E YS G S D ++ + + E SGS + E SE+ ++
Sbjct: 1073 DTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQ 1132
Query: 58 DGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHG 117
K V E + + +Q D S S +SD E++D N G
Sbjct: 1133 RTSSKKKAVIVKEKKR------NSLRTSTKRKQADITSSS-------SSDIEDDDQNSIG 1179
Query: 118 SDSESEE-----TRKLPGSD------SENEELLNGHA-----SDSENEDVGKHPASDSEI 161
S E+ T L S S +E L+ D ++ D A +
Sbjct: 1180 EGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL 1239
Query: 162 EELQ------KSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEE 215
EE++ + +SD E E+ K + E P +A + N E SDS+SEE
Sbjct: 1240 EEIKANLSSDEDGSSDDEPEEG-KKRTGKQNEENPGDEEAKNQVNSE------SDSDSEE 1292
Query: 216 LPKPQ-----------VSDSESEE-----PPRHQASDSENEELPKPRISDSESEDPPRHQ 259
KP+ VSD ES E P H+ N ++S +SED +
Sbjct: 1293 SKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRR----KVSSEDSEDSDFQE 1348
Query: 260 ASDSENEELPKPRISDSESEDPPRNQ-ASDSENEELPKPRVSDSESEGPQKGPASDSETE 318
+ SE +S+SE E PR + A +E EE + + + S SE +
Sbjct: 1349 SGVSEE-------VSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENK 1401
Query: 319 DASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRK--KFHSSDSEEEEHKKQKMD 376
S +++ + +++ + E + E+ E +ND S +K K D E + +
Sbjct: 1402 SNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKE 1461
Query: 377 SDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAK-KSRVVSDADDSDSD 423
+E K E + + K + + ED +++V D D+ +
Sbjct: 1462 EEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKE 1509
Score = 65.5 bits (158), Expect = 2e-10
Identities = 160/779 (20%), Positives = 287/779 (36%), Gaps = 125/779 (16%)
Query: 30 EDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHR 89
E+D+N + D + E+++ K H V D++ A E
Sbjct: 372 EEDLNSEFRAMDAVNKEKNT------------KEHKVIDAK----FETKARKGEKPCALE 415
Query: 90 QKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENE 149
+KD S+SE + DSE+ N +E + T K G + H E
Sbjct: 416 KKDI-SKSEAKLSRKQVDSEHMHQNV---PTEEQRTNKSTGGE---------HKKSDRKE 462
Query: 150 DVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMS 209
+ PA+ SE ++ S ED + + E + HQ S E
Sbjct: 463 EPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTE------Q 516
Query: 210 DSESEELPKPQVSDSESEEPPRHQASDSENEE---------LPKPRISDSESEDPPRHQ- 259
+ ES + K +S ++ + + + +E L I ++ ++ P+ +
Sbjct: 517 EVESSSV-KLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKD 575
Query: 260 --ASDSENEELPKPRI--SDSESEDPPRNQAS--DSENEELPKPRVSDSESEGP-QKGPA 312
S N +L K + +S++E N+ S E++ PRV + P + P
Sbjct: 576 GYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPV 635
Query: 313 ---SDSETEDASRHKQK---------PESDDDSDREN-------KGEDTEMQNDSFHSDS 353
SD E + + KQK + DS +N K + +E + + SD
Sbjct: 636 TSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDE 695
Query: 354 HMD-----RKKFHSSDSE---EEEHKKQKMDSDEDEKEGEEEK-VAKRKAAVLSDSEDEE 404
+ + HSS S+ E H K D + G+++K KRK++ D +
Sbjct: 696 MLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTK 755
Query: 405 KASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSE 464
K + KS ++S S+ + EK I S S+ A + + KD S+ E
Sbjct: 756 KGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDE 815
Query: 465 SGNEE-------ENLIADIFGESGD-EEEEEFTGFNQEDLEEEKGETQV-------KEAE 509
+++ +NL G S D E ++E F+ + +K T + K+ +
Sbjct: 816 KHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQ 875
Query: 510 DSDSDDNIKR--GKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVK- 566
S S D + + GK F S E+ + K + + D+ + K
Sbjct: 876 ASASTDGVDKLSGKEQSFTS-LEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKD 934
Query: 567 -MNEAAEEDRQ-----LNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVM----SAI 616
+E +E+D++ +KKP+ K ++ + D E + + I
Sbjct: 935 QSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGI 994
Query: 617 KEWLSPLPDRSLPALKIREELLKILQELPSVSQETL--------------KHSGIGRAVM 662
K+ + D + KIR++ K EL ++++ K+ GR
Sbjct: 995 KQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKK 1054
Query: 663 YLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTR-EEREQRDLEQMPQRRRMNS 720
K SR +D + ++S G S+ K + R E RE+R+L + + S
Sbjct: 1055 RCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQS 1113
Score = 65.5 bits (158), Expect = 2e-10
Identities = 130/656 (19%), Positives = 251/656 (38%), Gaps = 133/656 (20%)
Query: 10 QSDDG----GATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLP---- 61
Q DG G P ++ G + D NE ++ + S+ S R P
Sbjct: 572 QDKDGYKSCGLNPKLEKCGLGQENSD--NEHLVENEVSLLLEESDLRRSPRVKTTPLRRP 629
Query: 62 -KGHHVTDSENDEPLNLNASDSESEELH---RQKDSDSESEERAEPPASDS-----ENED 112
+ + VT + ++E N + E ++L R+KD + S+ + P + ++E
Sbjct: 630 TETNPVTSNSDEE---CNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSET 686
Query: 113 VNQHGSDSES----EETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSP 168
V+Q+ E +E ++ S S + ++ H + D+ D + + +KS
Sbjct: 687 VDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSS 746
Query: 169 ASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEE 228
S S+ + S + R S+S N DSE E+ E +
Sbjct: 747 TSGSDFDTKKGKSAKSSIISKKKRQTQSESSNY--------DSELEK---------EIKS 789
Query: 229 PPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASD 288
+ A+ + + +P + DS SE+E+ K + + ++ +Q
Sbjct: 790 MSKIGAARTTKKRIPNTKDFDS------------SEDEKHSKKGMDNQGHKNLKTSQEGS 837
Query: 289 SENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGED------- 341
S++ E + R + S +EG + E D KQ+ + D + G++
Sbjct: 838 SDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLE 897
Query: 342 ----TEMQNDSFHSDSHMDRK-------------KFHSSDSEEEEHKKQKMDSDEDEKEG 384
E + S H + +K K SD E+ KKQ E++K+
Sbjct: 898 VRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP 957
Query: 385 EE--EKVAKRKAAVLSDSEDEEKASAKK---------SRVVSDADDSD--SDAVSDKSGK 431
+ +KV K + S S+ EK ++ ++ + D + S + DK+ K
Sbjct: 958 SDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSK 1017
Query: 432 REKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGF 491
++ ++ +E+ GK D + +D + G E++ + G+S + ++
Sbjct: 1018 KKDELSDYAEKSTGK--GDSCDSSEDKKSKNGAYGREKKR--CKLLGKSSRKRQD----C 1069
Query: 492 NQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRR-RNRDGG 550
+ D E + +KE + SD +KR + L+ ++++S KR + G
Sbjct: 1070 SSSDTE----KYSMKEDGCNSSDKRLKR-----------IELRERRNLSSKRNTKEIQSG 1114
Query: 551 TFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKET 606
+ SDA E + ED + Q+ + KK AV++ KK++ T
Sbjct: 1115 SSSSDA------------EESSEDNKKKKQRTSSKKK-----AVIVKEKKRNSLRT 1153
Score = 35.0 bits (79), Expect = 0.28
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 7/116 (6%)
Query: 73 EPLNLNASDSESEELHR-QKDSDSESEERAEPP--ASDSENEDVNQHGSDSESEETRKLP 129
EP++ + ++ ++LH S ESEE + PP A + + ++ GS+S+ E K
Sbjct: 4 EPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEE 63
Query: 130 GSDSENEELLNGHA-SDSENEDVGKHPASDSE---IEELQKSPASDSETEDALKPQ 181
G+ S + +G + S + V K+ SD E +E AS+ +E+ + Q
Sbjct: 64 GTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQ 119
Score = 32.7 bits (73), Expect = 1.4
Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 4/133 (3%)
Query: 356 DRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVS 415
D KK H + E+ + + MD+ EK +E KV K + ++ A KK S
Sbjct: 363 DIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKS 422
Query: 416 DADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIAD 475
+A S S+ + T + + G E KK++ K+ E N E+L D
Sbjct: 423 EAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGE--HKKSDRKE--EPQYEPANTSEDLDMD 478
Query: 476 IFGESGDEEEEEF 488
I E+ F
Sbjct: 479 IVSVPSSVPEDIF 491
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 85.5 bits (210), Expect = 2e-16
Identities = 126/589 (21%), Positives = 228/589 (38%), Gaps = 95/589 (16%)
Query: 4 EYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETS------DRE 57
++ DQSD+ T D++ S E+ +E+ E+ + +RE
Sbjct: 967 KFLKKDQSDE---TSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPERE 1023
Query: 58 D--GLPKG-----HHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSEN 110
+ PKG + TD E + + + +EL SD + + + DS
Sbjct: 1024 EICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDEL-----SDYAEKSTGKGDSCDSSE 1078
Query: 111 EDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSE-----IEELQ 165
+ +++G+ ++ KL G S + + +SD+E + + + S+ IE +
Sbjct: 1079 DKKSKNGAYGREKKRCKLLGKSSRKRQ--DCSSSDTEKYSMKEDGCNSSDKRLKRIELRE 1136
Query: 166 KSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSE 225
+ S ++ S S++EE SE+ + K R S + + K + +S
Sbjct: 1137 RRNLSSKRNTKEIQSGSSSSDAEE-------SSEDNKKKKQRTSSKKKAVIVKEKKRNSL 1189
Query: 226 SEEPPRHQA-----SDSENEELPKPRISDSESEDPPRHQASD-------------SENEE 267
R QA S S+ E+ + I + S++ ++ S +E
Sbjct: 1190 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEA 1249
Query: 268 LPKP---RISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHK 324
L K + D + ++ P N+ + E K +S E +SD E E+ +
Sbjct: 1250 LSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDG------SSDDEPEEGKKRT 1303
Query: 325 QKPESDDDSDRENKGE-DTEMQNDSFHSDS-----HMDRKKFHSSDSEEEEHKKQKMDSD 378
K ++ D E K + ++E +DS S + R K SD E E KK K
Sbjct: 1304 GKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTK---- 1359
Query: 379 EDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIAS 438
KE +E K R+ DSED + + S VS+++D +S K+ +
Sbjct: 1360 --PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRT--RSAKKAEL--- 1412
Query: 439 DSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEE 498
EE + KK + DS S N+ + +EEEEE +E+ EE
Sbjct: 1413 ---EENQRSYKQKKKRRRIKVQEDSSSENKSNS----------EEEEEEK---EEEEEEE 1456
Query: 499 EKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNR 547
E+ E + ++ D R K L D ++ + + ++ + R +
Sbjct: 1457 EEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRK 1505
Score = 81.3 bits (199), Expect = 3e-15
Identities = 116/554 (20%), Positives = 217/554 (39%), Gaps = 72/554 (12%)
Query: 19 VQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNL- 77
++ + +S SDG + + E+ + +N T+D E K T + DE +
Sbjct: 1005 MEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYA 1064
Query: 78 -----------NASDSESE------ELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS 120
++ D +S+ E R K S +R + +SD+E + + G +S
Sbjct: 1065 EKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNS 1124
Query: 121 ESEETRKLPGSDSEN-------EELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSE 173
+ +++ + N +E+ +G +S E SE + +K S +
Sbjct: 1125 SDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES--------SEDNKKKKQRTSSKK 1176
Query: 174 TEDALKPQISDSESEEPPRHQA-----SDSENEEPPKPRMSDSESEELPKPQVSDSE--S 226
+K + +S R QA S S+ E+ + + + S+E V+++ S
Sbjct: 1177 KAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLS 1236
Query: 227 EEPPRHQASDSE--NEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSE--SEDPP 282
Q+S E ++ +P D + DP A EE+ SD + S+D P
Sbjct: 1237 SHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEP 1296
Query: 283 RN--QASDSENEELPKPRVSDSESEGPQKGPASDSETEDAS----RHKQKPESDDDSDRE 336
+ + +NEE P D E++ Q SDS++E++ RH+ SD E
Sbjct: 1297 EEGKKRTGKQNEENP----GDEEAKN-QVNSESDSDSEESKKPRYRHRLLRHKLTVSDGE 1351
Query: 337 NKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEE-KVAKRKAA 395
+ GE+ + + +R+K S DSE+ + ++ + + E E E+ + K A
Sbjct: 1352 S-GEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKA 1410
Query: 396 VLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEE 455
L +++ K K+ R+ D S + + + + EK + EEE +E D+ ++
Sbjct: 1411 ELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDS 1470
Query: 456 K---------------DLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEK 500
K D +++++ +EE E E E+ ED K
Sbjct: 1471 KSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTK 1530
Query: 501 GETQVKEAEDSDSD 514
K D D +
Sbjct: 1531 CPITTKLVLDEDEE 1544
Score = 75.1 bits (183), Expect = 2e-13
Identities = 106/468 (22%), Positives = 175/468 (37%), Gaps = 77/468 (16%)
Query: 2 DSEYYS----GDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRE 57
D+E YS G S D ++ + + E SGS + E SE+ ++
Sbjct: 1111 DTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQ 1170
Query: 58 DGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHG 117
K V E + + +Q D S S +SD E++D N G
Sbjct: 1171 RTSSKKKAVIVKEKKR------NSLRTSTKRKQADITSSS-------SSDIEDDDQNSIG 1217
Query: 118 SDSESEE-----TRKLPGSD------SENEELLNGHA-----SDSENEDVGKHPASDSEI 161
S E+ T L S S +E L+ D ++ D A +
Sbjct: 1218 EGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL 1277
Query: 162 EELQ------KSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEE 215
EE++ + +SD E E+ K + E P +A + N E SDS+SEE
Sbjct: 1278 EEIKANLSSDEDGSSDDEPEEG-KKRTGKQNEENPGDEEAKNQVNSE------SDSDSEE 1330
Query: 216 LPKPQ-----------VSDSESEE-----PPRHQASDSENEELPKPRISDSESEDPPRHQ 259
KP+ VSD ES E P H+ N ++S +SED +
Sbjct: 1331 SKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRR----KVSSEDSEDSDFQE 1386
Query: 260 ASDSENEELPKPRISDSESEDPPRNQ-ASDSENEELPKPRVSDSESEGPQKGPASDSETE 318
+ SE +S+SE E PR + A +E EE + + + S SE +
Sbjct: 1387 SGVSEE-------VSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENK 1439
Query: 319 DASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRK--KFHSSDSEEEEHKKQKMD 376
S +++ + +++ + E + E+ E +ND S +K K D E + +
Sbjct: 1440 SNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKE 1499
Query: 377 SDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAK-KSRVVSDADDSDSD 423
+E K E + + K + + ED +++V D D+ +
Sbjct: 1500 EEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKE 1547
Score = 65.5 bits (158), Expect = 2e-10
Identities = 160/779 (20%), Positives = 287/779 (36%), Gaps = 125/779 (16%)
Query: 30 EDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHR 89
E+D+N + D + E+++ K H V D++ A E
Sbjct: 410 EEDLNSEFRAMDAVNKEKNT------------KEHKVIDAK----FETKARKGEKPCALE 453
Query: 90 QKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENE 149
+KD S+SE + DSE+ N +E + T K G + H E
Sbjct: 454 KKDI-SKSEAKLSRKQVDSEHMHQNV---PTEEQRTNKSTGGE---------HKKSDRKE 500
Query: 150 DVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMS 209
+ PA+ SE ++ S ED + + E + HQ S E
Sbjct: 501 EPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTE------Q 554
Query: 210 DSESEELPKPQVSDSESEEPPRHQASDSENEE---------LPKPRISDSESEDPPRHQ- 259
+ ES + K +S ++ + + + +E L I ++ ++ P+ +
Sbjct: 555 EVESSSV-KLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKD 613
Query: 260 --ASDSENEELPKPRI--SDSESEDPPRNQAS--DSENEELPKPRVSDSESEGP-QKGPA 312
S N +L K + +S++E N+ S E++ PRV + P + P
Sbjct: 614 GYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPV 673
Query: 313 ---SDSETEDASRHKQK---------PESDDDSDREN-------KGEDTEMQNDSFHSDS 353
SD E + + KQK + DS +N K + +E + + SD
Sbjct: 674 TSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDE 733
Query: 354 HMD-----RKKFHSSDSE---EEEHKKQKMDSDEDEKEGEEEK-VAKRKAAVLSDSEDEE 404
+ + HSS S+ E H K D + G+++K KRK++ D +
Sbjct: 734 MLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTK 793
Query: 405 KASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSE 464
K + KS ++S S+ + EK I S S+ A + + KD S+ E
Sbjct: 794 KGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDE 853
Query: 465 SGNEE-------ENLIADIFGESGD-EEEEEFTGFNQEDLEEEKGETQV-------KEAE 509
+++ +NL G S D E ++E F+ + +K T + K+ +
Sbjct: 854 KHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQ 913
Query: 510 DSDSDDNIKR--GKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVK- 566
S S D + + GK F S E+ + K + + D+ + K
Sbjct: 914 ASASTDGVDKLSGKEQSFTS-LEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKD 972
Query: 567 -MNEAAEEDRQ-----LNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVM----SAI 616
+E +E+D++ +KKP+ K ++ + D E + + I
Sbjct: 973 QSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGI 1032
Query: 617 KEWLSPLPDRSLPALKIREELLKILQELPSVSQETL--------------KHSGIGRAVM 662
K+ + D + KIR++ K EL ++++ K+ GR
Sbjct: 1033 KQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKK 1092
Query: 663 YLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTR-EEREQRDLEQMPQRRRMNS 720
K SR +D + ++S G S+ K + R E RE+R+L + + S
Sbjct: 1093 RCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQS 1151
Score = 65.5 bits (158), Expect = 2e-10
Identities = 130/656 (19%), Positives = 251/656 (38%), Gaps = 133/656 (20%)
Query: 10 QSDDG----GATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLP---- 61
Q DG G P ++ G + D NE ++ + S+ S R P
Sbjct: 610 QDKDGYKSCGLNPKLEKCGLGQENSD--NEHLVENEVSLLLEESDLRRSPRVKTTPLRRP 667
Query: 62 -KGHHVTDSENDEPLNLNASDSESEELH---RQKDSDSESEERAEPPASDS-----ENED 112
+ + VT + ++E N + E ++L R+KD + S+ + P + ++E
Sbjct: 668 TETNPVTSNSDEE---CNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSET 724
Query: 113 VNQHGSDSES----EETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSP 168
V+Q+ E +E ++ S S + ++ H + D+ D + + +KS
Sbjct: 725 VDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSS 784
Query: 169 ASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEE 228
S S+ + S + R S+S N DSE E+ E +
Sbjct: 785 TSGSDFDTKKGKSAKSSIISKKKRQTQSESSNY--------DSELEK---------EIKS 827
Query: 229 PPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASD 288
+ A+ + + +P + DS SE+E+ K + + ++ +Q
Sbjct: 828 MSKIGAARTTKKRIPNTKDFDS------------SEDEKHSKKGMDNQGHKNLKTSQEGS 875
Query: 289 SENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGED------- 341
S++ E + R + S +EG + E D KQ+ + D + G++
Sbjct: 876 SDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLE 935
Query: 342 ----TEMQNDSFHSDSHMDRK-------------KFHSSDSEEEEHKKQKMDSDEDEKEG 384
E + S H + +K K SD E+ KKQ E++K+
Sbjct: 936 VRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP 995
Query: 385 EE--EKVAKRKAAVLSDSEDEEKASAKK---------SRVVSDADDSD--SDAVSDKSGK 431
+ +KV K + S S+ EK ++ ++ + D + S + DK+ K
Sbjct: 996 SDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSK 1055
Query: 432 REKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGF 491
++ ++ +E+ GK D + +D + G E++ + G+S + ++
Sbjct: 1056 KKDELSDYAEKSTGK--GDSCDSSEDKKSKNGAYGREKKR--CKLLGKSSRKRQD----C 1107
Query: 492 NQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRR-RNRDGG 550
+ D E + +KE + SD +KR + L+ ++++S KR + G
Sbjct: 1108 SSSDTE----KYSMKEDGCNSSDKRLKR-----------IELRERRNLSSKRNTKEIQSG 1152
Query: 551 TFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKET 606
+ SDA E + ED + Q+ + KK AV++ KK++ T
Sbjct: 1153 SSSSDA------------EESSEDNKKKKQRTSSKKK-----AVIVKEKKRNSLRT 1191
Score = 35.0 bits (79), Expect = 0.28
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 7/116 (6%)
Query: 73 EPLNLNASDSESEELHR-QKDSDSESEERAEPP--ASDSENEDVNQHGSDSESEETRKLP 129
EP++ + ++ ++LH S ESEE + PP A + + ++ GS+S+ E K
Sbjct: 4 EPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEE 63
Query: 130 GSDSENEELLNGHA-SDSENEDVGKHPASDSE---IEELQKSPASDSETEDALKPQ 181
G+ S + +G + S + V K+ SD E +E AS+ +E+ + Q
Sbjct: 64 GTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQ 119
Score = 32.7 bits (73), Expect = 1.4
Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 4/133 (3%)
Query: 356 DRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVS 415
D KK H + E+ + + MD+ EK +E KV K + ++ A KK S
Sbjct: 401 DIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKS 460
Query: 416 DADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIAD 475
+A S S+ + T + + G E KK++ K+ E N E+L D
Sbjct: 461 EAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGE--HKKSDRKE--EPQYEPANTSEDLDMD 516
Query: 476 IFGESGDEEEEEF 488
I E+ F
Sbjct: 517 IVSVPSSVPEDIF 529
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 85.1 bits (209), Expect = 2e-16
Identities = 162/759 (21%), Positives = 303/759 (39%), Gaps = 106/759 (13%)
Query: 86 ELHRQKDSDS--ESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHA 143
EL RQK + E+E A D E E + + E R+ + EE G
Sbjct: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ------KQEEESLGQV 62
Query: 144 SDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEP 203
+D + A +S +E K+ ++++ E D E+ R + EE
Sbjct: 63 TDQVEVN-----AQNSVPDEEAKTTTTNTQVE-------GDDEAAFLERL----ARREER 106
Query: 204 PKPRMSDS-ESEELPKPQVSDSESEEPPRHQASDS-ENEELPKPRISDSESEDPPRHQAS 261
+ R+ ++ E ++ P ++D+ P R +D+ ENE K S+S R +
Sbjct: 107 RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSES------RQERY 160
Query: 262 DSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDAS 321
+ E E ++ D N+ D E EE E E P++G +++ E
Sbjct: 161 EIEETETVTKSYQKNDWRDAEENKKEDKEKEE--------EEEEKPKRGSIGENQVEVMV 212
Query: 322 RHKQKPESDDD----------SDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHK 371
K ++ S E K E+ Q SD +K D E E +
Sbjct: 213 EEKTTESQEETVVMSLKNGQISSEEPKQEEEREQG----SDEISHHEKMEEEDKERAEAE 268
Query: 372 KQKMDSDEDE--KEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKS 429
+ +++++E E K +++K+A +A + E EEKA+A++ R +A++ + +K
Sbjct: 269 RARLEAEERERIKAEQDKKIADERARI----EAEEKAAAQE-RERREAEERERMREEEKR 323
Query: 430 GKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFT 489
E+ + E+ A +E K EEK + + EEE A+ + EEEE+
Sbjct: 324 AAEERQRIKEEEKRAAEERQRIKEEEKRA-AEERQRIKEEEKRAAEERQRARAEEEEK-- 380
Query: 490 GFNQEDLEEEKGETQVKEAEDSDSDDNIK--------RGKHMDFLSDFEMMLQRK----- 536
+EE+K Q++E + + + IK GK ++ E LQ
Sbjct: 381 ----AKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQ 436
Query: 537 ------KSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTL 590
K + + + D TF +++ I K E EE + ++KK + +
Sbjct: 437 GEEKGTKVQAKREKLQEDKPTF--KKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
Query: 591 LPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQE 650
+ H K + + TF G +++ + + A K EEL + E S E
Sbjct: 495 NGEFMTH-KLKHTENTFSRPGGRASV-DTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 552
Query: 651 TLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLE 710
LK A+ +E + ++ K++ E + ++ K REE E+R L+
Sbjct: 553 KLKQKQQEAALEL-----EELKKKREERRKVLEEEEQRRKQEEADRK--LREEEEKRRLK 605
Query: 711 QMPQRRRMNSTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNV 770
+ +RRR + + ++ E L+ ++K + P + + + +++ +
Sbjct: 606 EEIERRR--AEAAEKRQKMPEDGLSDDKKPFKCFTP---KGSSLKIEERAEFLNKSVQKS 660
Query: 771 EMESSRFQATSKKGISRLDKQMRKFTDIRKKSRSAHAVK 809
S QA +S++D ++ ++T + ++SA K
Sbjct: 661 SGVKSTHQAAI---VSKIDSRLEQYTSAIEGTKSAKPTK 696
Score = 79.0 bits (193), Expect = 2e-14
Identities = 120/629 (19%), Positives = 226/629 (35%), Gaps = 67/629 (10%)
Query: 49 SENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDS 108
+ENET+++E+ + E E + + ++ + K D E EE
Sbjct: 142 AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE--------- 192
Query: 109 ENEDVNQHGSDSESEETRKLPGSDSENEE------LLNGHASDSENEDVGKHPASDSEIE 162
E E+ + GS E++ + +E++E L NG S E + + EI
Sbjct: 193 EEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEIS 252
Query: 163 ELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVS 222
+K D E +A + ++ E+EE R +A + + R+ E + +
Sbjct: 253 HHEKMEEEDKERAEAERARL---EAEERERIKAEQDKKIADERARIEAEEKAAAQERERR 309
Query: 223 DSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELP--KPRISDSESED 280
++E E R + + E + RI + E Q E + + RI + E
Sbjct: 310 EAEERERMREEEKRAAEE---RQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 366
Query: 281 PPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPES---DDDSDREN 337
Q + +E EE K + +K A + +QK E ++ +E+
Sbjct: 367 AEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQED 426
Query: 338 K---------GEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDE-----DEKE 383
K GE+ + + D+ F + ++E+ KK K +E D K+
Sbjct: 427 KLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKK 486
Query: 384 GEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEE 443
G E ++ + + E ++ S A ++GKR + + E
Sbjct: 487 GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGET 546
Query: 444 AGKELSD--KKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKG 501
+E +K +E L + + EE + + + +EE + +E+ K
Sbjct: 547 ESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 606
Query: 502 ETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRN-------RDGGTFIS 554
E + + AE ++ + D F+ + S+ + R + G +
Sbjct: 607 EIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKST 666
Query: 555 DADDVVSAMIVKMNE--AAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDS-- 610
+VS + ++ + +A E + KPA L + V ++K K S
Sbjct: 667 HQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPT 726
Query: 611 --------------GVMSAIKEWLSPLPD 625
GV S I EWL+ PD
Sbjct: 727 AAGTPNKETAGLKVGVSSRINEWLTKTPD 755
Score = 72.8 bits (177), Expect = 1e-12
Identities = 102/520 (19%), Positives = 208/520 (40%), Gaps = 68/520 (13%)
Query: 35 EQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSD 94
E+ G T VE +++N D E + + + DE L E ++
Sbjct: 56 EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGD-DEAAFLERLARREERRQKRLQEA 114
Query: 95 SESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKH 154
E ++ +P +D+ S S +R++ +ENE S+S E +
Sbjct: 115 LERQKEFDPTITDA-----------SLSLPSRRMQNDTAENETTEKEEKSESRQERY-EI 162
Query: 155 PASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESE 214
+++ + QK+ D+E E+ + + + E EE P+ + S EN+ +ES+
Sbjct: 163 EETETVTKSYQKNDWRDAE-ENKKEDKEKEEEEEEKPK-RGSIGENQVEVMVEEKTTESQ 220
Query: 215 E------LPKPQVSDSE----------SEEPPRHQASDSENEELPKPRISDSESEDPPRH 258
E L Q+S E S+E H+ + E++E + + E+E+ R
Sbjct: 221 EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI 280
Query: 259 QASDSENEELPKPRISDSESEDPPRNQASDSENEEL----------PKPRVSDSESEGPQ 308
+A + + RI E + ++E E + R+ + E +
Sbjct: 281 KAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAE 340
Query: 309 KGPASDSETEDASRHKQKPESD-----DDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSS 363
+ E + A+ +Q+ + + ++ R E+ + + + + ++ KK
Sbjct: 341 ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQ 400
Query: 364 DSE-EEEHKKQKMDSD-EDEKEGEEEKVAKRKAAVLSDSEDEE--KASAKKSRVVSDADD 419
+++ + E +QK++ +EK+ +E+K+ + AVL +E+ K AK+ ++ D
Sbjct: 401 ETKIKGEKVEQKIEGKWVNEKKAQEDKL---QTAVLKKQGEEKGTKVQAKREKLQEDKPT 457
Query: 420 SDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGE 479
+ + D+ K++K +E K D+K ++ + E + + F
Sbjct: 458 FKKEEIKDEKIKKDK-----EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR 512
Query: 480 SG-----DEEEEE-----FTGFNQEDLEEEKGETQVKEAE 509
G D +E E G E+L +GET+ +E E
Sbjct: 513 PGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 552
Score = 44.3 bits (103), Expect = 5e-04
Identities = 62/385 (16%), Positives = 149/385 (38%), Gaps = 35/385 (9%)
Query: 43 GSVERHSENETSDREDGLPK--GHHVTDSENDEPLNLNASDSESEELHRQKDSDSE--SE 98
G + + +RE G + H + E+ E + E+EE R K + ++
Sbjct: 231 GQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIAD 290
Query: 99 ERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENE-----DVGK 153
ERA A + + E E R+ +E + + + E + K
Sbjct: 291 ERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEK 350
Query: 154 HPASDSE-IEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSE 212
A + + I+E +K A E + A + ++ EE R++ + + + ++ +
Sbjct: 351 RAAEERQRIKEEEKRAAE--ERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEK 408
Query: 213 SEE-LPKPQVSDSESEEPPRHQASDSENEELPKPRIS---DSESEDPPRHQASDSENEEL 268
E+ + V++ +++E A + E ++ + ED P + + ++E++
Sbjct: 409 VEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKI 468
Query: 269 PKPRISDSESEDPPRNQAS----DSENEELPKPRVSDSESEGPQKGPASDSETEDAS--- 321
K + E + + S+N E ++ +E+ + G + +T++A
Sbjct: 469 KKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAP 528
Query: 322 ------------RHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEE 369
R + + ES++ + K ++ ++ + RK + ++
Sbjct: 529 QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ 588
Query: 370 HKKQKMDSDEDEKEGEEEKVAKRKA 394
+ + +E+EK +E++ +R+A
Sbjct: 589 EEADRKLREEEEKRRLKEEIERRRA 613
Score = 39.7 bits (91), Expect = 0.011
Identities = 44/228 (19%), Positives = 89/228 (39%), Gaps = 7/228 (3%)
Query: 347 DSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKA 406
D F + R+K E E Q+ D DE+E E + A+++ L ++EE
Sbjct: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQER--LRQKQEEESL 59
Query: 407 SAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESG 466
+V +A +S D + K+ + D E + L+ ++ + E
Sbjct: 60 GQVTDQVEVNAQNSVPDEEA-KTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118
Query: 467 NEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFL 526
E + I D + T N+ +EEK E++ + E +++ K + D+
Sbjct: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
Query: 527 SDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEED 574
E + K+ + + + G S ++ V M+ + ++E+
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRG----SIGENQVEVMVEEKTTESQEE 222
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 84.3 bits (207), Expect = 4e-16
Identities = 112/571 (19%), Positives = 225/571 (39%), Gaps = 81/571 (14%)
Query: 9 DQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL-PKGHHVT 67
+Q+++ T E + E++ E+ G + + E ++ E+ P+ +
Sbjct: 459 EQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKS 518
Query: 68 DSENDEPLNLNASDSESEELHR-------QKDSDSESEERAEPPASDSENEDVNQHGSDS 120
+ + A E EE +K EE PP + S ++ + ++
Sbjct: 519 PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV 578
Query: 121 ESEETRKLPGSDSENE--ELLNGHASDSENEDVGKHPA-SDSEIEELQKSPASDSETEDA 177
+S E K P + E + + S ++ K PA + S ++E KSPA E A
Sbjct: 579 KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKA 638
Query: 178 LKPQISDSESEE----PPRHQASDSENEEPP------------KPRMSDSESEELPKPQV 221
P +++S E P + +A E + P P ++++S E K V
Sbjct: 639 KSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPV 698
Query: 222 -----SDSESEEPPRHQASDSENEELP--KPRISDSESEDPPRHQASDSENEELPKPR-- 272
S +++ P + +A E + P + + +++ P + +A E + P+
Sbjct: 699 KEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKT 758
Query: 273 --ISDSESEDPPRNQASDSEN-----------EELPKPRVSDS----ESEGPQKGPASDS 315
+ E++ P + +A + EE+ P + S +++ P+K
Sbjct: 759 LDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE 818
Query: 316 ETEDASRHKQKPESDDDSDRENKGED--------TEMQNDSFHSDS--------HMDRKK 359
E + + ++KP+ + K E+ TE + DS ++ ++ KK
Sbjct: 819 EVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKK 878
Query: 360 FHSSDSEEEEHKKQKMDSDEDEKE-GEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDAD 418
+ + +E + K + ED+K+ EK A K V D++ +EK K + D
Sbjct: 879 EPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK----EPD 934
Query: 419 DSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFG 478
D+ + S + K+E E++ KE KK EEK E++ ++
Sbjct: 935 DAKAKEPSKPAEKKEAA----PEKKDTKEEKAKKPEEKP---KTEAKAKEDDKTLSKEPS 987
Query: 479 ESGDEEEEEFTGFNQEDLEEEKGETQVKEAE 509
+ E+ E+ + +Q+D + + T+ K A+
Sbjct: 988 KPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
Score = 66.2 bits (160), Expect = 1e-10
Identities = 66/347 (19%), Positives = 139/347 (40%), Gaps = 31/347 (8%)
Query: 10 QSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDS 69
+S + +PV++E S + V E+ + E +T ++ K +
Sbjct: 689 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPE 748
Query: 70 ENDEPLNLNASDSESEELHR--QKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRK 127
+ P D +S E ++++ S +++ E S + E + + S +E K
Sbjct: 749 KAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAK 808
Query: 128 LPGSDSENEELLNGHASDSEN--EDVGKHPASDSEIEELQKSPASDSETEDALKPQISDS 185
P + +E + + E E K P +E E+ +P ++ E +D+ K +
Sbjct: 809 APEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE-EKKDSKKEEAPKK 867
Query: 186 ESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPP----RHQASDSENEE 241
E+ +P + + E+P + ++ + E K +V E E P + A E E
Sbjct: 868 EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTE 927
Query: 242 LPKPRISDSESEDPPR--------HQASDSENEELPKPRISDSESEDPPRNQASDSENEE 293
+ K D+++++P + + D++ E+ KP E+ P+ +A E+++
Sbjct: 928 VAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKP-------EEKPKTEAKAKEDDK 980
Query: 294 LPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGE 340
S ++E +K ++D + KP D+ KG+
Sbjct: 981 TLSKEPSKPKAEKAEKSSSTDQK-------DSKPPEKATEDKAAKGK 1020
Score = 60.1 bits (144), Expect = 8e-09
Identities = 60/317 (18%), Positives = 123/317 (38%), Gaps = 22/317 (6%)
Query: 142 HASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENE 201
H E + S+ E +++ TE+ + + +++ EE + + E
Sbjct: 435 HIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA 494
Query: 202 EPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQAS 261
E + +EE P + E++ P + +A S +E++ P + +A
Sbjct: 495 EGGEEETKSPPAEEAASP---EKEAKSPVKEEAK------------SPAEAKSPEKEEAK 539
Query: 262 DSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDA- 320
+ P+ S ++ E +A E EE P ++ +S K PA + A
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSP--AEVKSPEKAKSPAKEEAKSPAE 597
Query: 321 SRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDED 380
++ +K +S + ++ E + S + + + S ++EE +K S E
Sbjct: 598 AKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEK 657
Query: 381 EKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSD-KSGKREKTIASD 439
E+ EK K+ V ++++ EKA + + + S + KS ++ K+ +
Sbjct: 658 EEAKSPEKA---KSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714
Query: 440 SEEEAGKELSDKKNEEK 456
+ K S K E K
Sbjct: 715 EAKSPEKAKSPVKEEAK 731
Score = 39.3 bits (90), Expect = 0.015
Identities = 65/332 (19%), Positives = 123/332 (37%), Gaps = 18/332 (5%)
Query: 194 QASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESE 253
Q +E + R ++ E+ + K + SE RHQA + +E + D+E
Sbjct: 315 QEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQL--DAELR 372
Query: 254 DPPRHQASD-SENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPA 312
+ A+ E ++L +++ + E + + E + + S EG K P+
Sbjct: 373 NTKWEMAAQLREYQDLLNVKMA-LDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPS 431
Query: 313 SDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKK 372
+ + S K K + + E TE + +++ EEE ++
Sbjct: 432 VSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEE 491
Query: 373 QKMDSDEDE-----------KEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSD 421
++ + E+E E E + K +A ++++ EK AK V + +
Sbjct: 492 EEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAK 551
Query: 422 SDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESG 481
S A + E A E+E K ++ K+ EK + E+ + E +
Sbjct: 552 SPAKEEAKSPPE---AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV 608
Query: 482 DEEEEEFTGFNQEDLEEEKGETQVKEAEDSDS 513
EE + EE K +VK E + S
Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKS 640
>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
Length = 674
Score = 81.6 bits (200), Expect = 3e-15
Identities = 115/549 (20%), Positives = 217/549 (39%), Gaps = 73/549 (13%)
Query: 1 MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENET-SDREDG 59
+ +E Y Q + T +D ++ D +V + G+ + + S+ + S+ E G
Sbjct: 47 LPAEIYQEPQPE----TEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPG 102
Query: 60 LPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEP---------PASDSEN 110
+ H SE + D E+ K+SD E E A+P A +++
Sbjct: 103 I---HQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDP 159
Query: 111 EDVNQHGSDSE----SEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQK 166
+ V + SE + R L + E E + + ++E+ G P ++ + +
Sbjct: 160 DPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSE 219
Query: 167 SPASDSETEDALKPQISDSESEEPPRHQASDSENEEPP----------KPRMSDSESEEL 216
E D P+++ E+ E + ++++ + EPP +PR S SE L
Sbjct: 220 KLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKS-SEEAGL 278
Query: 217 PKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKP----R 272
P+ + E E + +A++ + ELP + D P H+ S +E +P+P +
Sbjct: 279 EPPEETQPEVPEEMQRKATEEKGTELP-----ERTKPDFPDHKPRKSTDENVPEPLEEIK 333
Query: 273 ISDSESEDPPRNQASDSENEELPKPRVSDS-ESEGPQKGPASDSETEDASRHKQKPESDD 331
+ E E N+ + E E+ KP + +K P ET + P+ ++
Sbjct: 334 LEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEE 393
Query: 332 DSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDE----DEKEGE-- 385
+ + + E+ +++ ++H++ F D E K + +DE + K G+
Sbjct: 394 KTQTKPTEKILELPDETKPRETHVE---FSKEDRPEPIKSKYSVGNDELEHREPKRGKLS 450
Query: 386 -EEKVAKRKAAVLSDSEDEEKASAK---KSRVVSDADDSDSDAVSDKSGKREKTIASDSE 441
+K K A+ S E EE + + S+ + SD S + + SE
Sbjct: 451 LSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTEL----SE 506
Query: 442 EEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEE--- 498
KE+ D E K+ D E+ E+ G E + E ++ E++ E
Sbjct: 507 FVHEKEVVDLSQELKERVSEDDETQPEK-----------GTELQFEHLNWDPEEVAEWIS 555
Query: 499 EKGETQVKE 507
+ G Q KE
Sbjct: 556 QLGFPQYKE 564
Score = 62.0 bits (149), Expect = 2e-09
Identities = 108/600 (18%), Positives = 215/600 (35%), Gaps = 30/600 (5%)
Query: 70 ENDEPLNLNASDSE-SEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSES---EET 125
EN EP + +DS+ E++++ ++E E+ E ++N + G+ E E
Sbjct: 33 ENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESK 92
Query: 126 RKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDS 185
R +P SE E ++ + ++G+ D E + SD E + KP +++
Sbjct: 93 RDVP---SETEPGIHQEVKSETSREMGEF-FKDLEAPMDETHKESDLEPPEEAKPNVTED 148
Query: 186 ESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPR--HQASDSENEELP 243
E D PP MS+ + + + E E P ++ ++EE
Sbjct: 149 VFLESAMETDPDPV---PPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETG 205
Query: 244 KPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSE 303
++ + P E +L P+++ E+ + + ++++ + E P+ +
Sbjct: 206 LEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFL 265
Query: 304 SEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSS 363
+ P+K + PE E KG + + D H RK +
Sbjct: 266 EKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPD-HKPRKSTDEN 324
Query: 364 DSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSD 423
E E K + +E K EE + + + E+ K++ KK+ +
Sbjct: 325 VPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKN---PQPPEETGP 381
Query: 424 AVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDE 483
+ + + + E EL D+ + E E I + DE
Sbjct: 382 VLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEP---IKSKYSVGNDE 438
Query: 484 EEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMML--QRKKSMSG 541
E + L ++ + +S+++I G H +FL + +L + S S
Sbjct: 439 LEHREPKRGKLSLSDKFRKEYYALGSLRESEESI--GTHYEFLQPLQKLLNVSEECSYSD 496
Query: 542 KRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQ 601
+ F+ + + V + +K + +++ Q + + L P V Q
Sbjct: 497 PSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTELQFEHLNWDPEEVAEWISQ 556
Query: 602 ----DLKETFIDSGV--MSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHS 655
KE FI + + I S LP + + + + + QEL + + K S
Sbjct: 557 LGFPQYKECFITNFISGRKLIHVNCSNLPQMGITNFEDMKAISRHTQELLEIEEPLFKRS 616
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 80.5 bits (197), Expect = 6e-15
Identities = 110/630 (17%), Positives = 252/630 (40%), Gaps = 39/630 (6%)
Query: 46 ERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPA 105
E+ + E +R D L K + + L + + L R++ E EER E
Sbjct: 564 EQRLKREQEERRDQLLKRE---EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Query: 106 SDSE-NEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEEL 164
E E+ Q SE +E R+ E +E E E+ + EE
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 165 QKSPASDSETEDA---LKPQIS------DSESEEPPRHQASDSENEEPPKPRMSDSESEE 215
++ ++ E E A +K +I +SE++ S +E + R E
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 216 LPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISD 275
+ ++ E E R Q + + + ++ +SE + ++ E + ++
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 276 SESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDD--DS 333
E + R Q E EE + R E E + + + + R +Q E +D
Sbjct: 801 EERQQ--REQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 334 DRENKGEDTEMQNDSFHSDSHMDRKK-----FHSSDSEEEEHKKQKMDSDEDEKEGEEEK 388
D+E + + ++ + +RK+ + +E+ K+Q++ +E+E+ EE+
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918
Query: 389 VAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKEL 448
+R+ +EE+ ++ +++ + + ++ +++K + E+ G+E
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEP 978
Query: 449 SDKKNEEKD-LFGSDSESGNEEENLIADIFGESGDEE-------EEEFTGFNQEDLEEEK 500
++ +E++ + + E EEE L+ + + +E ++E ++ L EE+
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038
Query: 501 GETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVV 560
+ +++E E ++ + + L + E +R++ + + R+ + + ++ +
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGE-ERETRRRQELERQYRKEEE----LQQEEEQL 1093
Query: 561 SAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWL 620
+ E +RQ +++ ++ LL ++Q+L+ + + + +E L
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 621 SPLPDRSLPALKIREELLKILQELPSVSQE 650
R P + R+EL + +E + QE
Sbjct: 1154 L----REEPEKRRRQELERQYREEEELQQE 1179
Score = 77.8 bits (190), Expect = 4e-14
Identities = 95/518 (18%), Positives = 190/518 (36%), Gaps = 51/518 (9%)
Query: 13 DGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSEND 72
DG + +QD R + ++ + G R E +E L +G SE
Sbjct: 104 DGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQE---QERELAEGEE--QSEKQ 158
Query: 73 EPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSD 132
E L EEL RQ+ E EER +E E + + ET + P +
Sbjct: 159 ERLEQRDRQRRDEELWRQRQEWQEREERR------AEEEQL----QSCKGHETEEFPDEE 208
Query: 133 S-ENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPP 191
ELL E + + D +E ++ ET L+ + + EEP
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRET--VLRKEEEKLQEEEPQ 266
Query: 192 RHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSE 251
R + E E+ + E +EL + + + + ++ R + +E + +
Sbjct: 267 RQRELQEEEEQ-----LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 252 SEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGP 311
E R + + E+ + R E + + + E E R + E Q
Sbjct: 322 REQQERREQQEERREQ--QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 312 ASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHK 371
E R +Q+ + RE + + + + R++ + EEE H
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQ----LRREQQLRREQQLRREQQLRREQEEERH- 434
Query: 372 KQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS--------DSD 423
+QK + + E+ + E+ +R + + + +K ++ D ++ + +
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE 494
Query: 424 AVSDKSGKREKTIASDSEEEAGKELSDKKNEEK--DLFGSDSESGNEEENLIADIFGESG 481
++ +RE+ + + EE + L ++ EE+ S+ + E+E
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE----------- 543
Query: 482 DEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKR 519
+ E+ ++ LE+E+ E ++K ++ D +KR
Sbjct: 544 ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR 581
Score = 71.2 bits (173), Expect = 4e-12
Identities = 130/707 (18%), Positives = 264/707 (37%), Gaps = 57/707 (8%)
Query: 83 ESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGH 142
+ EE H QK E+R + + + + ++ +E RK + EE
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 143 ASDSENEDVGKHPASDSEI----EELQKSPASDSETEDALKPQISDSESEEPPRHQASDS 198
E E + + ++ EE ++ E E+ L+ ++ + + + +
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 199 ENEEPPKPRMSDSESEELPKPQVSDSES-----EEPPRHQASDSENEE-----LPKPRIS 248
+ + R+ E+ K + + EE R Q E EE L + +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 249 DSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQ 308
E E+ + E EE + ++ SE ++ R Q E +E + R+ E E +
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE-ER 667
Query: 309 KGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEE 368
E E+ R ++ E + + RE S++ + K +S ++E
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Query: 369 -----EHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSED-------EEKASAKKSRVVSD 416
+ +++K E E + +EE+ A R+ D EEK+ + R+ +
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787
Query: 417 ---ADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLI 473
+ + +++ +RE+ + EEE + ++ EK+L + E +
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPE-EEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846
Query: 474 ADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKR-------GKHMDFL 526
+ E +E++ +QE ++K Q++E + K L
Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906
Query: 527 SDFEMMLQRKKSMSGKRRRNRDGGTF-----ISDADDVVSAMIVKMNEAAEEDRQLNNQK 581
+ E LQR++ KRRR + + ++ + + E +RQ K
Sbjct: 907 QEEEEELQREE--REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Query: 582 KPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKIL 641
K K+ LL ++Q+ ++ + + + +E L +R + E +
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL-REEREKRRRQEWERQYRKK 1023
Query: 642 QELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINE--WSRPIFGLTSNYKGM 699
EL ++ L+ R + + +E + +L+ E +R L Y+
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR-- 1081
Query: 700 TREEREQRDLEQM----PQRRRMNSTGGQTPRRDLEKVLTGEEKALR 742
+EE Q++ EQ+ P++RR Q R+ E++ EE+ LR
Sbjct: 1082 -KEEELQQEEEQLLREEPEKRRRQERERQC--REEEELQQEEEQLLR 1125
Score = 62.8 bits (151), Expect = 1e-09
Identities = 69/431 (16%), Positives = 171/431 (39%), Gaps = 11/431 (2%)
Query: 85 EELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHAS 144
E R++ E EE+ + E E Q + E + R+ E E+ L
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Query: 145 DSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPP 204
+++ + ++EE +K + AL+ Q+ + ++ + + + + EE
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR--KEQQLLQEEEEELQREERE 919
Query: 205 KPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSE 264
K R + E + + Q+ E E+ R + +E + D + + +
Sbjct: 920 KRRRQEQERQYREEEQLQQEE-EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEP 978
Query: 265 NEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHK 324
+ + R E+ + + EE K R + E + +K E + +
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038
Query: 325 QKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEG 384
+K + + + E+ + + + + R++ E +++K++ E+E+
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGEERETRRR----QELERQYRKEEELQQEEEQLL 1094
Query: 385 EEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEA 444
EE +R+ +EE+ ++ +++ + + ++ + E+ + + E+
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 445 GKELSDKKNEEKD-LFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGET 503
+E ++ +E + + + E EEE L+ + + E E ++ +E+L+ +K +
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR--EEEELQRQKRKQ 1212
Query: 504 QVKEAEDSDSD 514
+ ++ ED SD
Sbjct: 1213 RYRD-EDQRSD 1222
Score = 62.4 bits (150), Expect = 2e-09
Identities = 93/524 (17%), Positives = 191/524 (36%), Gaps = 35/524 (6%)
Query: 46 ERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPA 105
E E + +PK +SE D + S +E R++ E R E
Sbjct: 687 EEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746
Query: 106 SDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQ 165
E E H E E+ R E+ G S + + EE Q
Sbjct: 747 QWQEEE--RAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQ 804
Query: 166 KSPASDSETEDALKPQISDSESEEPPRHQASDS----ENEEPPKPRMSDSESEELPKPQV 221
+ E P+ + E R + E EE + R + +E
Sbjct: 805 -------QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857
Query: 222 SDSE---SEEPPRHQASDSENEE---------LPKPRISDSESEDPPRHQASDSE--NEE 267
D E S+E R Q + EE KP + + ++ Q + E EE
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 268 LPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDS-ETEDASRHKQK 326
K R + E + Q E + L + R E ++ + ++ ++
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 327 PESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDE---KE 383
PE +RE K + E +R+K + E + KK ++ +E++ +E
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 384 GEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEE 443
E+ ++ +R+ +EE+ ++ +++ + ++ ++ ++E+ + + E+
Sbjct: 1038 REKRRLQERERQY----REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Query: 444 AGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGET 503
+E ++ +E++ + E +EE + E +E E +E++++E+ +
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 504 QVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNR 547
+E E + ++ + + L E L R++ ++ R R
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Score = 60.5 bits (145), Expect = 6e-09
Identities = 76/473 (16%), Positives = 183/473 (38%), Gaps = 33/473 (6%)
Query: 85 EELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEET----RKLPGSDSENEELLN 140
EE +++ + E + R E E + + + +E RK E E+LL
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 141 GHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSEN 200
++ + + E+++ ++ + + + EE + +
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 201 EEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQA 260
EEP K R + E + + ++ + EE + + +E + + E + R Q
Sbjct: 1156 EEPEKRRRQELERQYREEEELQ--QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 261 SDSENEELPKPRISDSESEDPPRNQ---ASDSENEE---LPKPRVSDSESEGPQKGPASD 314
E++ + E E+ R+ ENE+ L ++ D +S+ + +
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273
Query: 315 SETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQK 374
+ D + +++ + D E + + E Q ++ D +K + EE+ ++Q+
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333
Query: 375 MDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREK 434
D E EE+ + +R+ L E + K ++ R + + +RE+
Sbjct: 1334 TDRKFRE---EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERER 1390
Query: 435 TIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQE 494
+ ++ +E + +++ D + EE+ L S E + +F
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDR-----DRKFREEEQQL-------SRQERDRKFRE---- 1434
Query: 495 DLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNR 547
EE++ Q +E + + + +++ +H F + +++ +R++ ++ R+R
Sbjct: 1435 --EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Score = 60.1 bits (144), Expect = 8e-09
Identities = 74/411 (18%), Positives = 154/411 (37%), Gaps = 23/411 (5%)
Query: 46 ERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPA 105
E + + RE L + E E E +E R++ E EER E
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQL 351
Query: 106 SDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQ 165
+ E+ + E EE R+ E+ L + + + E ++L+
Sbjct: 352 RREQEEERREQQLRREQEEERR--EQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLR 408
Query: 166 KSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSE 225
+ E + + Q+ + EE RH+ + + + E + K +
Sbjct: 409 REQQLRREQQLRREQQLRREQEEE--RHEQKHEQERREQRLKREQEERRDWLKREEETER 466
Query: 226 SEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQ 285
E+ R Q + EE + R E E+ R + + ++L + E E+ +
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLEEEE--RREQQERREQQLRR------EQEERREQR 518
Query: 286 ASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQ 345
E EE + R+ SE + + + R ++K + ++ K E E +
Sbjct: 519 LKRQEEEERLQQRL---RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575
Query: 346 NDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEK 405
+ + +++ E+EE +Q++ +E E+ +EE+ +R L E EE+
Sbjct: 576 DQLLKREEERRQQRLKR---EQEERLEQRLKREEVERLEQEERREQR----LKREEPEEE 628
Query: 406 ASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEK 456
+ + + ++ +RE+ + + EEE ++ +++EE+
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679
Score = 48.1 bits (113), Expect = 3e-05
Identities = 109/635 (17%), Positives = 229/635 (36%), Gaps = 52/635 (8%)
Query: 186 ESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSE--NEELP 243
+ E+ R + D + EE P R E+ + + +SE+ R + D + +EEL
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW 174
Query: 244 KPRISDSE-----SEDPPRHQASDSENEELPKP-----------RISDSESEDPPRNQAS 287
+ R E +E+ E EE P R E + R +
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 288 D------SENEELPKPRVSDSESEGPQKG-PASDSETEDASRHKQKPESDDDSDRENKGE 340
D E E + V E E Q+ P E ++ +K E + RE + E
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE-LRRERQEE 293
Query: 341 DTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQ--KMDSDEDEKEGEEEKVAKRKAAVLS 398
E Q + + RK+ ++EE ++Q + + E+ +E + + + +
Sbjct: 294 --EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQL 351
Query: 399 DSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDL 458
E EE+ ++ R + + + ++ +RE+ + + + ++L ++ ++
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411
Query: 459 FGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIK 518
+ E+ L + E +++ E+ + E+E+ +K E+++ + +
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 519 RGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLN 578
R + + + E + K +RR ++ ++ + +++L
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQER-----------REQQLRREQEERREQRLK 520
Query: 579 NQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELL 638
Q++ + L + ++++ +E + +++ +R LK +E
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQ------ERREQRLKREQEER 574
Query: 639 K--ILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNY 696
+ +L+ Q+ LK R L + E ++ + +
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 697 KGMTREEREQRDLEQMPQRRRMNSTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPM 756
K +EER Q+ L + Q RR + LE+ L E + R A
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE--LAEEEQEQ 692
Query: 757 PSNKDYVVRPKWNVEMESSRFQATSKKGISRLDKQ 791
+ PKW ++ES A K SR KQ
Sbjct: 693 ARERIKSRIPKWQWQLESEA-DARQSKVYSRPRKQ 726
Score = 43.5 bits (101), Expect = 8e-04
Identities = 72/432 (16%), Positives = 157/432 (36%), Gaps = 26/432 (6%)
Query: 83 ESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDS---ENEELL 139
+ + H ++ E EE+ E D ++++ Q + E EE R+ +D E E+LL
Sbjct: 1287 QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE-EREEKRRRQETDRKFREEEQLL 1345
Query: 140 NGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSE 199
+ E+ Q+ E E L+ Q + + + +
Sbjct: 1346 QEREEQPLRRQERDRKFREEELRH-QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404
Query: 200 NEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQ 259
++ + R EE Q+S E + R + +E + + + + RH+
Sbjct: 1405 EQQLRQDRDRKFREEE---QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461
Query: 260 ASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETED 319
E + L + ++ R + + + E E + P E+
Sbjct: 1462 KFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE 1521
Query: 320 ASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDR-KKFHSSDSEEEEHKKQKMDSD 378
H+Q+ + R+ E+ +++ DR +KF + +E ++Q++
Sbjct: 1522 QQLHRQQRQ------RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ 1575
Query: 379 E-DEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIA 437
E D K EE+ +R+ EDE++ ++ + D+ + ++ +
Sbjct: 1576 ERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ-------QQLRQERDRKFREDEQLL 1628
Query: 438 SDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLE 497
+ EE+ +L ++ + K L E E + EEE+ ++ L
Sbjct: 1629 QEREEQ---QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685
Query: 498 EEKGETQVKEAE 509
++ + + +E E
Sbjct: 1686 RQERDRKFREEE 1697
Score = 38.9 bits (89), Expect = 0.020
Identities = 51/295 (17%), Positives = 109/295 (36%), Gaps = 21/295 (7%)
Query: 81 DSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLN 140
+ E ++LHRQ+ EE EP E E +H D + E +L + E ++L
Sbjct: 1630 EREEQQLHRQERDRKFLEE--EPQLRRQEREQQLRHDRDRKFREEEQLL-QEGEEQQLRR 1686
Query: 141 GHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSEN 200
E+ + + E + LQ+ + Q+ E E R + +
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQE------------EQQLRRQELERKFREEEQLRQE 1734
Query: 201 EEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQA 260
E + R + + L + Q+ E+ R Q D + E + ++ E R Q
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE--EEQLRQEREEQQLRSQE 1792
Query: 261 SDSENEELPKPRISDSESEDPPRNQAS----DSENEELPKPRVSDSESEGPQKGPASDSE 316
SD + E + R E + P+ + + E +L + + Q
Sbjct: 1793 SDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFA 1852
Query: 317 TEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHK 371
T++ SR +++ ++ + + + +++ + +++ + + +E K
Sbjct: 1853 TQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
Score = 37.0 bits (84), Expect = 0.074
Identities = 54/325 (16%), Positives = 122/325 (37%), Gaps = 22/325 (6%)
Query: 83 ESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGH 142
E E+L ++++ S + + E + Q E+ ++L + + +
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 143 ASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEE 202
E+E + + E ++L + E+ +PQ+ E E+ RH EE
Sbjct: 1619 RKFREDEQL----LQEREEQQLHRQERDRKFLEE--EPQLRRQEREQQLRHDRDRKFREE 1672
Query: 203 PPKPRMSDSESEELPKPQVSDS--ESEEPPRHQASD----SENEELPKPRISDSESEDPP 256
+ + + E ++L + + E E+ R Q + E ++L + + E+
Sbjct: 1673 --EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730
Query: 257 RHQASDSEN--------EELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQ 308
Q ++ E + L + ++ E R Q D + E + R E +
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790
Query: 309 KGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEE 368
+ E+ R +++ + R+ K E Q + + +++ +EE+
Sbjct: 1791 QESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850
Query: 369 EHKKQKMDSDEDEKEGEEEKVAKRK 393
++K +E E EEE+ +++
Sbjct: 1851 FATQEKSRREEQELWQEEEQKRRQE 1875
Score = 36.6 bits (83), Expect = 0.097
Identities = 48/282 (17%), Positives = 106/282 (37%), Gaps = 47/282 (16%)
Query: 266 EELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQ 325
+E + R ES R Q D E PR E E Q+ E E ++
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFE---PRDRQLEEEPGQRRRQKRQEQE-----RE 147
Query: 326 KPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGE 385
E ++ S+++ + E + Q +EE ++++ + +E+ E
Sbjct: 148 LAEGEEQSEKQERLEQRDRQR------------------RDEELWRQRQEWQEREERRAE 189
Query: 386 EEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAG 445
EE++ K + DEE+ ++ ++ + + ++++ + E+E
Sbjct: 190 EEQLQSCKGHETEEFPDEEQ--LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR 247
Query: 446 KELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQV 505
K + + EE+ L + + E + EEEE+ +++L E+
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQ------------EEEEQLRKLERQELRRER----- 290
Query: 506 KEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNR 547
E+ ++R + + + E Q+++ + RR +
Sbjct: 291 --QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Score = 34.7 bits (78), Expect = 0.37
Identities = 39/223 (17%), Positives = 88/223 (39%), Gaps = 10/223 (4%)
Query: 330 DDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKV 389
D++ G+++ +Q+ D + + E + ++QK E E EE+
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 390 AKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGK--- 446
K++ D + ++ ++ + + ++ ++ +S K +T EE+ +
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 447 -ELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQV 505
EL K EEK + E ++ + E + E +E L+EE+ + Q
Sbjct: 216 LELRRKGREEK------QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 506 KEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRD 548
+ E+ + ++R + + E QR + RR+ +
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312
>gi|16445033 ACRC protein [Homo sapiens]
Length = 691
Score = 80.5 bits (197), Expect = 6e-15
Identities = 89/377 (23%), Positives = 153/377 (40%), Gaps = 47/377 (12%)
Query: 66 VTDSENDEPLNLNASDSESEELHRQKDSDSESEERA-------EPPASDSENEDVNQHGS 118
V DS++DE + + E + + +SD ES E EPP S++++ + +G+
Sbjct: 78 VIDSDSDEECHTH---EEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDNDDDNGN 134
Query: 119 DSESEETRKLPGSDSENEELLNGHASDSE----NEDVGKHPASDSEIEELQKSPASDSET 174
D E +P +S++ E + ++ DSE N D + P +S+ E + DS+
Sbjct: 135 DLE------VPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDV 188
Query: 175 EDALKPQISDSESEEPPRHQASDSE--NEEPPKPRMSDSESEELPKPQVSDSESEEPPRH 232
D SD S++ + DS+ +++ + D S++ P S +SE P
Sbjct: 189 PDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSDDSEAP--- 245
Query: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPR--NQASDSE 290
D +++ P S +SE P S++ E P DSE+ D ++ASD
Sbjct: 246 ---DDSSDDSEAPDDSSDDSEAPD----DSSDDSEAPDDSSDDSEASDDSSDDSEASDDS 298
Query: 291 NEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDD--------SDRENKGEDT 342
+++ P +S+ P+ +D S + P +D SD E E
Sbjct: 299 SDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEAA 358
Query: 343 E--MQNDSFHSDSHMDRKKFHS---SDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVL 397
Q+DS D + S SD E ++ E+E E+ KRK+
Sbjct: 359 AAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVSERKLPTEEEPAPVVEQSGKRKSKTK 418
Query: 398 SDSEDEEKASAKKSRVV 414
+ E K K +V
Sbjct: 419 TIVEPPRKRQTKTKNIV 435
Score = 74.3 bits (181), Expect = 4e-13
Identities = 86/351 (24%), Positives = 149/351 (42%), Gaps = 64/351 (18%)
Query: 185 SESEEPPRHQAS-------DSENE----EPPKPRM----SDSESEEL--PKPQVSDSESE 227
S + P+ QAS DS+ E E K ++ SD ES E KP + +
Sbjct: 63 SVARRAPKRQASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAI-----Q 117
Query: 228 EPPRHQASDSENE------ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDP 281
EPP + D ++ E+P DSE+ D +S++ E P DSE+ D
Sbjct: 118 EPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPD------DNSDDSEAPDDNSDDSEAPD- 170
Query: 282 PRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSD-RENKGE 340
+S++ E P DS+ +SD ++D+S ++ DDSD ++K +
Sbjct: 171 -----DNSDDSEAPDDNSDDSDVPDDNSDDSSDDNSDDSS-----DDNSDDSDVPDDKSD 220
Query: 341 DTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDS 400
D+++ +DS D S ++ + D D+ E ++ +A DS
Sbjct: 221 DSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAP--DDS 278
Query: 401 EDEEKASAKKSRVVSDADDS--DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDL 458
D+ +AS S +DDS DS+A DKS + + D +++ ++ D +++ ++
Sbjct: 279 SDDSEASDDSSDDSEASDDSSDDSEAPDDKSD--DSDVPEDKSDDS--DVPDDNSDDLEV 334
Query: 459 FGSDSESGNEEENLIADIFGESGDEEE--EEFTGFNQEDLEEEKGETQVKE 507
+ NE + + DEEE E +Q D ++ GE + E
Sbjct: 335 PVPAEDLCNEGQ--------IASDEEELVEAAAAVSQHDSSDDAGEQDLGE 377
Score = 73.6 bits (179), Expect = 7e-13
Identities = 78/357 (21%), Positives = 143/357 (40%), Gaps = 40/357 (11%)
Query: 7 SGDQSDD--GGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGH 64
S D +DD G V D+ S+ DD ++ D S + + ++ SD +
Sbjct: 124 SDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNS 183
Query: 65 HVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSD--SES 122
+D +D N+ DS + D +S+ + + + DS+ D + SD +S
Sbjct: 184 DDSDVPDD-----NSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDS 238
Query: 123 EETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQI 182
+ + P S++ E + + DSE D S++ + S ASD ++D+
Sbjct: 239 SDDSEAPDDSSDDSEAPDDSSDDSEAPD-DSSDDSEAPDDSSDDSEASDDSSDDSEASDD 297
Query: 183 SDSESEEP-PRHQASDSENEEPPKPRMSDSESEELPKP----------QVSDSESE---- 227
S +SE P + SD ++ + D S++L P Q++ E E
Sbjct: 298 SSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEA 357
Query: 228 --EPPRHQASDSENEELPKPRISDSESEDPPRHQASDSE--NEELPKPRISDSESE---- 279
+H +SD E+ +S S+ + S+ + EE P P + S
Sbjct: 358 AAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVSERKLPTEEEPAPVVEQSGKRKSKT 417
Query: 280 ----DPPRNQASDSEN-EELPKPRVSDSES--EGPQKGPASDSETEDASRHKQKPES 329
+PPR + + ++N E P+ R + +++ E +K A HK++ S
Sbjct: 418 KTIVEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLRKRKAKTKNVSVTPGHKKRGPS 474
Score = 70.9 bits (172), Expect = 5e-12
Identities = 82/371 (22%), Positives = 144/371 (38%), Gaps = 59/371 (15%)
Query: 153 KHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSE 212
+ P D + L +SD + S + P+ QAS N + S S
Sbjct: 12 QEPEEDEDCYILNVQSSSDDTS--------GSSVARRAPKRQASCILNVQSRSGDTSGSS 63
Query: 213 -SEELPKPQVS-----DSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENE 266
+ PK Q S DS+S+E + E K ++ + S+D
Sbjct: 64 VARRAPKRQASSVVVIDSDSDE-------ECHTHEEKKAKLLEINSDDESPECCHVKPAI 116
Query: 267 ELPKPRISDSESEDPPRN--QASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHK 324
+ P ISD +++D N + D +++ P + +SE P + DSE D +
Sbjct: 117 QEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDN-SDDSEAPDDN--- 172
Query: 325 QKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEG 384
SDD ++ +D+++ +D+ SD +++ D + D+ +
Sbjct: 173 ----SDDSEAPDDNSDDSDVPDDN--------------SDDSSDDNSDDSSDDNSDDSDV 214
Query: 385 EEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEA 444
++K SD D S+ S V D+ D DS+A D S E S + EA
Sbjct: 215 PDDK---------SDDSDVPDDSSDDSDVPDDSSD-DSEAPDDSSDDSEAPDDSSDDSEA 264
Query: 445 GKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQ 504
+ SD D SD +++ + ++ +S D+ E + D+ E+K +
Sbjct: 265 PDDSSDDSEAPDD--SSDDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDD- 321
Query: 505 VKEAEDSDSDD 515
+ D +SDD
Sbjct: 322 -SDVPDDNSDD 331
Score = 65.1 bits (157), Expect = 3e-10
Identities = 71/315 (22%), Positives = 140/315 (44%), Gaps = 36/315 (11%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLP 61
+S+ S D SDD + V D++ SD DD ++ D S + + +++SD +
Sbjct: 200 NSDDSSDDNSDD---SDVPDDKSDDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPD 256
Query: 62 KGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSE 121
+++ +D + A D S++ DS +SE ASD ++D D +
Sbjct: 257 DSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSE------ASDDSSDD--SEAPDDK 308
Query: 122 SEETRKLPGSDSENEELLNGHASDSE----NEDVGKHPASDSEIEELQKSPASDSE---T 174
S+++ +P S++ ++ + ++ D E ED+ S+ EEL ++ A+ S+ +
Sbjct: 309 SDDS-DVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEAAAAVSQHDSS 367
Query: 175 EDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESE------- 227
+DA + + ++ S+ P S+ E P+ +EE P P V S
Sbjct: 368 DDAGEQDLGENLSKPP-------SDPEANPEVSERKLPTEEEPAPVVEQSGKRKSKTKTI 420
Query: 228 -EPPRHQASDSEN-EELPKPRISDSES-EDPPRHQASDSENEELPKPRISDSESEDPPRN 284
EPPR + + ++N E P+ R + +++ +P R + + ++N + S+ P
Sbjct: 421 VEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLRKRKAKTKNVSVTPGHKKRGPSKKKPGA 480
Query: 285 QASDSENEELPKPRV 299
+ PK +V
Sbjct: 481 AKVEKRKTRTPKCKV 495
Score = 62.0 bits (149), Expect = 2e-09
Identities = 76/339 (22%), Positives = 134/339 (39%), Gaps = 41/339 (12%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHS--GSDTGSVERHSENETSDREDG 59
DSE + D D+ D D DD ++ +S SD S + ++ SD D
Sbjct: 165 DSEAPDDNSDDSEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDV 224
Query: 60 LPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSD 119
+D +D + A D S++ DS +SE P S ++E + D
Sbjct: 225 PDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSE---APDDSSDDSEAPDDSSDD 281
Query: 120 SESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALK 179
SE+ + S++ E + + DSE D K SD ++ S D ++D
Sbjct: 282 SEASD------DSSDDSEASDDSSDDSEAPD-DKSDDSDVPEDKSDDSDVPDDNSDDLEV 334
Query: 180 P----------QISDSESE------EPPRHQASDSENEEPPKPRMSDSESEELPKPQVSD 223
P QI+ E E +H +SD E+ +S S+ P+VS+
Sbjct: 335 PVPAEDLCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVSE 394
Query: 224 SE--SEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSEN-EELPKPRISDSES-E 279
+ +EE P E+ K + +PPR + + ++N E P+ R + +++
Sbjct: 395 RKLPTEEEPAPVV-----EQSGKRKSKTKTIVEPPRKRQTKTKNIVEPPRKRQTKTKNIV 449
Query: 280 DPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETE 318
+P R + + ++N + + GP K ++ E
Sbjct: 450 EPLRKRKAKTKNVSV----TPGHKKRGPSKKKPGAAKVE 484
Score = 59.3 bits (142), Expect = 1e-08
Identities = 93/405 (22%), Positives = 156/405 (38%), Gaps = 52/405 (12%)
Query: 210 DSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELP 269
D +ELP+ Q + + + + S S++ S + P+ QAS N +
Sbjct: 2 DGCKKELPRLQEPEEDEDCYILNVQSSSDDTS------GSSVARRAPKRQASCILNVQSR 55
Query: 270 KPRISDSE-SEDPPRNQAS-----DSENEELPKPRVSDSESEGPQKGPASDSETEDASRH 323
S S + P+ QAS DS+++E + E + SD E+ +
Sbjct: 56 SGDTSGSSVARRAPKRQASSVVVIDSDSDEECH---THEEKKAKLLEINSDDESPECCHV 112
Query: 324 K---QKPE---SDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDS 377
K Q+P SDDD+D +N G D E+ +D+ D S ++ + D
Sbjct: 113 KPAIQEPPIVISDDDNDDDN-GNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDD 171
Query: 378 DEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIA 437
+ D+ E ++ + V D+ D+ +S S SD + DSD DKS +
Sbjct: 172 NSDDSEAPDDN--SDDSDVPDDNSDD--SSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDD 227
Query: 438 SDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLE 497
S + + + SD +E D DSE+ ++ + D ++ E + +D E
Sbjct: 228 SSDDSDVPDDSSDD-SEAPDDSSDDSEAPDDSSD---DSEAPDDSSDDSEAPDDSSDDSE 283
Query: 498 EEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDG-------- 549
+ EA D SDD+ + D SD + + K S N D
Sbjct: 284 ASDDSSDDSEASDDSSDDS----EAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAE 339
Query: 550 -----GTFISDADDVVSAMIV-----KMNEAAEEDRQLNNQKKPA 584
G SD +++V A ++A E+D N K P+
Sbjct: 340 DLCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPS 384
Score = 58.5 bits (140), Expect = 2e-08
Identities = 77/330 (23%), Positives = 127/330 (38%), Gaps = 36/330 (10%)
Query: 206 PRMSDSESEE----LPKPQVSDSES-----EEPPRHQASDSENEELPKPRISDSE-SEDP 255
PR+ + E +E L SD S P+ QAS N + S S +
Sbjct: 9 PRLQEPEEDEDCYILNVQSSSDDTSGSSVARRAPKRQASCILNVQSRSGDTSGSSVARRA 68
Query: 256 PRHQAS-------DSENE----ELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSES 304
P+ QAS DS+ E E K ++ + S+D + P +SD ++
Sbjct: 69 PKRQASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDN 128
Query: 305 EGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSD 364
+ +D E D + SDD ++ +D+E +D+ D +S D
Sbjct: 129 DDDN---GNDLEVPDDN-------SDDSEAPDDNSDDSEAPDDNSDDSEAPDD---NSDD 175
Query: 365 SEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDA 424
SE + D +D + + + + SD D + S V D+ D DSD
Sbjct: 176 SEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSD-DSDV 234
Query: 425 VSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEE 484
D S E S + EA + SD +E D DSE+ ++ + S D E
Sbjct: 235 PDDSSDDSEAPDDSSDDSEAPDDSSD-DSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSE 293
Query: 485 EEEFTGFNQEDLEEEKGETQVKEAEDSDSD 514
+ + + E +++ ++ V E + DSD
Sbjct: 294 ASDDSSDDSEAPDDKSDDSDVPEDKSDDSD 323
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 79.7 bits (195), Expect = 1e-14
Identities = 106/499 (21%), Positives = 199/499 (39%), Gaps = 73/499 (14%)
Query: 47 RHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPAS 106
R ++ S R GL + H +D + E +RQK+ + E+R +
Sbjct: 29 RRPGSQESPRRRGLGQAH-------------KDADGDDRERNRQKERERRREKRQTERET 75
Query: 107 DSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQK 166
D + E + + + R+ + E D + E +E +
Sbjct: 76 DRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQRE------------KERNR 123
Query: 167 SPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSES 226
+ ETE + + R + D+E E + R +D E + Q +
Sbjct: 124 QKERERETEREGERGRDRQTDGQRERERQRDAEKE---RERQTDRERQR----QTERNRQ 176
Query: 227 EEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQA 286
+E R + + E E + R ++++ED RH E E + R +++E+E R +
Sbjct: 177 KERER-EKNRQERRERERQREKENKTED--RHSERGRERE---RERETETETE---RKRQ 227
Query: 287 SDSENEELPKPRVSDSESE-GPQKGPASDSETE-DASRHKQKPESDDDSDRENKGEDTEM 344
+D E + + R ++ E E ++ AS+ ETE D R + E D D DR+ + ++ E
Sbjct: 228 TDRERD---RQRKTEREREKQAERERASERETERDKERER---ERDRDRDRDRRQKERER 281
Query: 345 QND-----SFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSD 399
Q D D +RK+ + E E + +K E+E E E+ +R+ D
Sbjct: 282 QTDRKRQRRTERDRETERKRERQRERERERERNRKR-----ERERERERERERQRETERD 336
Query: 400 SEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLF 459
E E + K+ + D + + + + G+R+ + E E ++ S ++ EE++
Sbjct: 337 REKERERKRKRQTEM----DRERNRQTGREGRRQAERERERERERDRQ-SAREREERERD 391
Query: 460 GSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKR 519
E D G+ E++ E ++D E E+G + +E E R
Sbjct: 392 RDRDRQKERERQTEKDRDGQRETEKQRE----REKDRESERGRERGREREKQKG-----R 442
Query: 520 GKHMDFLSDFEMMLQRKKS 538
+ + +D + QRK+S
Sbjct: 443 ERDRERQTDRQAGRQRKRS 461
Score = 76.6 bits (187), Expect = 8e-14
Identities = 90/467 (19%), Positives = 184/467 (39%), Gaps = 43/467 (9%)
Query: 125 TRKLPGSDSENEELLNGHA-SDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQIS 183
+R+ PGS G A D++ +D ++ E E ++ ++ ET+ + +
Sbjct: 27 SRRRPGSQESPRRRGLGQAHKDADGDDRERN--RQKERERRREKRQTERETDRKRERRRE 84
Query: 184 DSESEEPPRHQASDSENEEPPKPRMSDSESE-----ELPKPQVSDSESE---EPPRHQAS 235
+ RH+ + E+ + R +D E + E + + + E+E E R + +
Sbjct: 85 KDRHRKRDRHRERQRDREKE-RERQTDRERDRQREKERNRQKERERETEREGERGRDRQT 143
Query: 236 DSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELP 295
D + E + R D+E E R + +D E + + + R + + E +
Sbjct: 144 DGQRE---RERQRDAEKE---RERQTDRERQRQTERNRQKEREREKNRQERRERERQREK 197
Query: 296 KPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHM 355
+ + D SE +G + E E + ++K ++D + DR+ K E + S
Sbjct: 198 ENKTEDRHSE---RGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASER 254
Query: 356 DRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVS 415
+ ++ D E E + + D D +KE E + KR+ D E E K ++ R
Sbjct: 255 ETER----DKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRER--- 307
Query: 416 DADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIAD 475
+ +++ KRE+ + E E +E + +E++ + E N
Sbjct: 308 -------ERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQT- 359
Query: 476 IFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQR 535
G G + E + + E E+ +E E+ + D + R K + ++ + QR
Sbjct: 360 --GREGRRQAE-----RERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412
Query: 536 KKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKK 582
+ +R ++R+ + + + + DRQ Q+K
Sbjct: 413 ETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459
Score = 72.4 bits (176), Expect = 2e-12
Identities = 92/446 (20%), Positives = 172/446 (38%), Gaps = 64/446 (14%)
Query: 27 SDGEDDVNEQHSGSDTGSVERHSENETS-DREDGLPKGHHVT-----------DSENDEP 74
+DG+D + + +R +E ET RE K H + E +
Sbjct: 49 ADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQ 108
Query: 75 LNLNASDSESEELHRQKDSDSESE---ERAEPPASDSENEDVNQHGSDSESEETRKLPGS 131
+ +E +RQK+ + E+E ER +D + E Q D+E E R+ +
Sbjct: 109 TDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR--DAEKERERQ---T 163
Query: 132 DSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPP 191
D E + ++ + + + E E ++ +++TED E
Sbjct: 164 DRERQ-----RQTERNRQKEREREKNRQERRERERQREKENKTEDR-----HSERGRERE 213
Query: 192 RHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSE 251
R + +++E E + R +D E + K + + E R +AS+ E E D E
Sbjct: 214 RERETETETE---RKRQTDRERDRQRKTEREREKQAE--RERASERETER-------DKE 261
Query: 252 SEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGP 311
E R + D + + K R ++ + R + + + R + E E +K
Sbjct: 262 RE---RERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRK-R 317
Query: 312 ASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHK 371
+ E E +++ E D + +RE K + + MDR++ + E
Sbjct: 318 ERERERERERERQRETERDREKERERKRK----------RQTEMDRERNRQTGREGRRQA 367
Query: 372 KQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGK 431
++ E E+E E ++ + R+ + E + +K R D D ++K +
Sbjct: 368 ER-----ERERERERDRQSARER---EERERDRDRDRQKERERQTEKDRDGQRETEKQRE 419
Query: 432 REKTIASDSEEEAGKELSDKKNEEKD 457
REK S+ E G+E +K E+D
Sbjct: 420 REKDRESERGRERGREREKQKGRERD 445
Score = 63.9 bits (154), Expect = 6e-10
Identities = 89/424 (20%), Positives = 161/424 (37%), Gaps = 57/424 (13%)
Query: 22 ERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASD 81
ER++ +GE + Q G +R +E E + TD E N
Sbjct: 128 ERETEREGERGRDRQTDGQRERERQRDAEKERERQ----------TDRERQRQTERNRQK 177
Query: 82 SESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESE-ETRKLPGSDSENEELLN 140
E +RQ+ + E + E D +E + + E+E ET + +D E +
Sbjct: 178 EREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERD---R 234
Query: 141 GHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSEN 200
++ E E ++ ++ AS+ ETE D E E R + D +
Sbjct: 235 QRKTERERE------------KQAERERASERETE-------RDKERER-ERDRDRDRDR 274
Query: 201 EEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQA 260
+ + R +D + + + D E+E Q E + R + E E Q
Sbjct: 275 RQKERERQTDRKRQRRTE---RDRETERKRERQRERERERERNRKRERERERERERERQR 331
Query: 261 SDSENEELPKPRISDSESE-DPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETED 319
+ E + R ++E D RN+ + E R ++ E E ++
Sbjct: 332 ETERDREKERERKRKRQTEMDRERNRQTGREGR-----RQAERERERERE------RDRQ 380
Query: 320 ASRHKQKPESDDDSDRENKGE-DTEMQND-SFHSDSHMDRKKFHSSDSEEE---EHKKQK 374
++R +++ E D D DR+ + E TE D ++ +R+K S+ E E +KQK
Sbjct: 381 SAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQK 440
Query: 375 MDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREK 434
+ E++ + + +RK + L + A +S VV + + + KS +
Sbjct: 441 GRERDRERQTDRQAGRQRKRSTLYVNPPPRTA---RSGVVQSDPNRPTRGIRWKSSPEDP 497
Query: 435 TIAS 438
AS
Sbjct: 498 KAAS 501
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 79.7 bits (195), Expect = 1e-14
Identities = 102/505 (20%), Positives = 187/505 (37%), Gaps = 52/505 (10%)
Query: 68 DSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRK 127
D ++D L + + R++DS + + P ++ D S+ E+T K
Sbjct: 867 DMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEK 926
Query: 128 ---LPGSDSENEELLNGHA-----------SDSENEDVGKHPASDSEIEELQK------- 166
+PG SE ++ A S E D G+ ++ EEL++
Sbjct: 927 HKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRD-GRAKPEEAHREELKECGCESGF 985
Query: 167 SPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSES 226
SD + L+P + E + D E +E KP +S + K + S E
Sbjct: 986 KDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEK 1045
Query: 227 EEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPK--PRISDSESEDPPRN 284
+ + + ++ K + D+ +D R + D E+ K P I + + +
Sbjct: 1046 CQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDD 1105
Query: 285 QASDSENEELPKPRVSDSESE-------GPQKGPASDSETEDASRHKQKPESDDDSDREN 337
+ ++ + +SE + G + G ASD D + K++ SDR
Sbjct: 1106 KKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHR 1165
Query: 338 KGEDT---EMQNDSFHSDSHMDRKKFHSSDSEEE---EHKKQKMDSDEDEK--------- 382
K D E Q D D DR + ++E E K+K D + EK
Sbjct: 1166 KSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRAS 1225
Query: 383 -EGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSE 441
+ ++K K+K ++ + + AK + + S +S EK++ E
Sbjct: 1226 VDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLE 1285
Query: 442 EEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGES-----GDEEEEEFTGFNQEDL 496
EEA E + N++ SDS + +E + S GD++ E ++
Sbjct: 1286 EEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLK 1345
Query: 497 EEEKGETQVKEAEDSDSDDNIKRGK 521
E+E+ ++ S + K+ K
Sbjct: 1346 EKERHRHSSSSSKKSHDRERAKKEK 1370
Score = 65.9 bits (159), Expect = 1e-10
Identities = 119/570 (20%), Positives = 222/570 (38%), Gaps = 70/570 (12%)
Query: 13 DGGATPVQDERDSGSD-----GEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVT 67
DG A P + R+ + G D ++ G ERH +++DG K
Sbjct: 963 DGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERK-- 1020
Query: 68 DSENDEPLNLNASDSE-SEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETR 126
+ E +SD + SE+ +K + ++ D++ + + HG D E + +
Sbjct: 1021 EKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKAS- 1079
Query: 127 KLPGSDSENEELLNGHASD--SENEDVGKHPASDSEIEEL-----------------QKS 167
L + E+ G S+ SE +D K I ++ +
Sbjct: 1080 -LDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMG 1138
Query: 168 PASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVS----- 222
ASD D L+ + E+ RH+ S S+ + P R D E + K + +
Sbjct: 1139 EASDLPRTDGLQEKEEGREAYASDRHRKS-SDKQHPE--RQKDKEPRDRRKDRGAADAGR 1195
Query: 223 DSESEEPPRH-QASDSENEELPKPRISDSESEDPPRHQASDSENEE-LPKPRISDSESED 280
D + + +H + D E+ E K R D S D D +N++ LP+ +ED
Sbjct: 1196 DKKEKVFEKHKEKKDKESTEKYKDR-KDRASVD----STQDKKNKQKLPEKAEKKHAAED 1250
Query: 281 PPRNQASDSENEELPKPRVSDSESEGPQ------KGPASDSETEDASRHKQKPESDDDSD 334
+++ + ++E K R S ++ + + A ED++ + SD +D
Sbjct: 1251 KAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTD 1310
Query: 335 RENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEE-EEHKKQKMDSDEDEKEGEEEKVAKRK 393
R + T SF D+ + + E+ +E ++ + S +K + E+ K K
Sbjct: 1311 RGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEK 1370
Query: 394 AAVLSDSEDEEKASAKKSRVVSDADDSDSDAV-------SDKSGKREKTIASDSEEEAGK 446
A ED ++ ++K + D ++DA +D + +KTI S E+ K
Sbjct: 1371 AEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDK 1430
Query: 447 ELSDK---KNEEKDL--FGSDSESGNEEENLIADIFGESGDEEE-------EEFTGFNQE 494
S++ K EK+L +GS + + +E+ + DE+E + +++
Sbjct: 1431 NDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRD 1490
Query: 495 DLEEEKGETQVKEAEDSDSDDNIKRGKHMD 524
+L + Q D DS + + K D
Sbjct: 1491 ELLRHHRDEQKPATRDKDSPPRVLKDKSRD 1520
Score = 59.3 bits (142), Expect = 1e-08
Identities = 95/495 (19%), Positives = 177/495 (35%), Gaps = 57/495 (11%)
Query: 20 QDERDSGSDGEDDVNEQHSGSDTGSVERHSE---------NETSDREDGLPKGHHVTDSE 70
+D ++ D E+ + D G ++ +E D + G K ++ D
Sbjct: 1060 KDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIF 1119
Query: 71 NDEP-------LNLNASDSESEELHRQKDSDSESEERAEPPASD----SENEDVNQHGSD 119
DE + E+ +L R D E EE E ASD S ++ + D
Sbjct: 1120 TDESEDDRDSCMGSGFKMGEASDLPRT-DGLQEKEEGREAYASDRHRKSSDKQHPERQKD 1178
Query: 120 SESEETRKLPGSDS----ENEELLNGHASDSENEDVGKHP--ASDSEIEELQKSPASDSE 173
E + RK G+ + E++ H + E K+ + ++ Q
Sbjct: 1179 KEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKL 1238
Query: 174 TEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSD-----SESEE 228
E A K ++ +++ + ++ ++E R +D+E L K + +S +
Sbjct: 1239 PEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSND 1298
Query: 229 PPRHQASDSENEELPKPRIS--------DSESEDPPRHQASDSENEELPKPRISDSESED 280
+SDS + +P ++ + +D PR A E + K R S S
Sbjct: 1299 KISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLK-EKERHRHSSSSS 1357
Query: 281 PPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETE----DAS--RHKQKPESDDDSD 334
+ ++ E+ K + EG + + E + DA + K + +D+ D
Sbjct: 1358 KKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELD 1417
Query: 335 RENKGEDTEMQ--NDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKR 392
+ + TE + NDS S K+ S K+K ++ ++ +EK R
Sbjct: 1418 KTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHR 1477
Query: 393 KAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKK 452
D + + ++ D A DK + D + G L D K
Sbjct: 1478 ------DRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPR--VLKDKSRDEGPRLGDAK 1529
Query: 453 NEEKDLFGSDSESGN 467
+EK G++ E G+
Sbjct: 1530 LKEKFKDGAEKEKGD 1544
Score = 46.6 bits (109), Expect = 9e-05
Identities = 113/591 (19%), Positives = 216/591 (36%), Gaps = 92/591 (15%)
Query: 80 SDSESEELHRQKDSDSE--SEERAEPPASDSENE---DVNQHGSDSESEETRKLPGSDSE 134
SDS L + D SE S E +P E+ +++ S S +P D E
Sbjct: 566 SDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKE 625
Query: 135 NEELLNGHASDSENEDVGKHPASDSEIEELQ------KSPASDSETEDALKPQISDSESE 188
+ ++ H + ++++ K S S+ +L+ + S+ L+ +S
Sbjct: 626 GK-VVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKL 684
Query: 189 EPPRHQASDSENEEP-PKPRMSDSE---SEELPKPQVSDSESEEPPRHQASDSENEELPK 244
+ +H + EE K ++ + E +E ++ D+ + + + + K
Sbjct: 685 KVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEK 744
Query: 245 PRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSES 304
R +S + + E ++ K R S E ++ + E E++ K D E
Sbjct: 745 ERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFK---EDKEK 801
Query: 305 EGPQKGPASDSETEDASRHKQKPESDD------------------DSDRENKGEDT---- 342
+K DS ++ Q E++D DS + KGED+
Sbjct: 802 LKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSP 861
Query: 343 -----EMQNDSF-----------HSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEE 386
+M++DS + D + D E +K+ D + E +
Sbjct: 862 VTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRK 921
Query: 387 EKVAKRKAA--VLSDSEDEEKASAKKSRVVSDADDS-----DSDAVSDKSGKRE------ 433
E+ K K+ LS+ + + + SA+ R DA +S D A +++ + E
Sbjct: 922 EQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGC 981
Query: 434 -KTIASDSEEEAGKELS-----------------DKKNEEKDLFGSDSESGNEEENLIAD 475
S+ + GK L DK+ +EK E ++++
Sbjct: 982 ESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKS 1041
Query: 476 IFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDF-EMMLQ 534
I + ++E + ++D +E+ +T K+ E S D K K F E +
Sbjct: 1042 ILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSE 1101
Query: 535 RKKSMSGKRRRNRDGGTFISDADDVVSAMI---VKMNEAAEEDRQLNNQKK 582
+K GK + F +++D + + KM EA++ R Q+K
Sbjct: 1102 KKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEK 1152
Score = 45.4 bits (106), Expect = 2e-04
Identities = 114/614 (18%), Positives = 221/614 (35%), Gaps = 111/614 (18%)
Query: 2 DSEYYSG------DQSDDGGATPVQDERDSGSDGEDD----VNEQH-----------SGS 40
DSE+ G + PV+DE + D E D V+++H S S
Sbjct: 320 DSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNS 379
Query: 41 DTGSVERHSENETSDREDGLPKGHH--VTDSENDEPLNLNASDSESEELHRQKD-SDSES 97
+ ++ T + K H ++D+ ++E ++ E L S++
Sbjct: 380 FISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKT 439
Query: 98 EERAEPPASDSENEDVNQHGSDSESEETR------KLPGSDSENEELLNGHASDSENEDV 151
E + +N+ + +++ E R K S+SE+E +G + + + +
Sbjct: 440 REPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESG---EDDRDSL 496
Query: 152 GKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDS 211
G L+ S + + S + ++ P H +++ + S
Sbjct: 497 GSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISS 556
Query: 212 ESEELPKPQVSD-SESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPK 270
+ +VS S+S SD +E + R +AS SE +
Sbjct: 557 PAWS----EVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKS--- 609
Query: 271 PRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSE-------TEDASRH 323
P +S +E P D E + + K + + +KG S S+ T +
Sbjct: 610 PFLSSAEGAVPKL----DKEGKVVKKHKTKHKH-KNKEKGQCSISQELKLKSFTYEYEDS 664
Query: 324 KQKPES----DDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSD--SEEEEHKKQKMDS 377
KQK + ++D ENK + + D F + + + K + ++E+ K+ D+
Sbjct: 665 KQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDT 724
Query: 378 DED----------------------EKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVS 415
++D EK +EEK+ K S+D KK
Sbjct: 725 NKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKK----- 779
Query: 416 DADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIAD 475
+D DK K ++ I + +E+ KE +++ D + + ++ E+
Sbjct: 780 ------NDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTK--- 830
Query: 476 IFGESGDEEEEEFTGFNQEDLE---EEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMM 532
F S D+ + F+ + + E+ ++ V + D SD K ++
Sbjct: 831 -FSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAK------------LI 877
Query: 533 LQRKKSMSGKRRRN 546
L+ K S +RRR+
Sbjct: 878 LETVKEDSKERRRD 891
Score = 45.1 bits (105), Expect = 3e-04
Identities = 100/519 (19%), Positives = 186/519 (35%), Gaps = 79/519 (15%)
Query: 165 QKSPASDSETEDA--LKPQIS------DSESEEPPRHQASDSENEEPPKPRM------SD 210
++S SE EDA P S DSE E+ +H+A + E ++ P D
Sbjct: 293 EESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDED 352
Query: 211 SESEELP-------------KPQVSDSESEEPPRHQASDSENEELPKPR-----ISDSES 252
E + +P K S+S P S ++N + + +SD+
Sbjct: 353 DEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASHRILSDTSD 412
Query: 253 EDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPA 312
E+ E L I P N E ++ K R +++ + G
Sbjct: 413 EEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKR 472
Query: 313 SDSETEDASRHKQKPESDDDSDREN-----KGEDTEMQNDSFHSDSHMDRKKFHSSDSEE 367
SD S + +DD D KG +++ S S H S + +
Sbjct: 473 SDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQ 532
Query: 368 EEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDA--- 424
K+ +D+ K + + + + SE + + ++R+ S++D S +
Sbjct: 533 ---KQNPSHTDQHTKHWRTDN--WKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVE 587
Query: 425 ----VSDKSGKREKTIASD------SEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIA 474
V + R++ S+ S E DK+ + + + N+E+
Sbjct: 588 SLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEK---- 643
Query: 475 DIFGESGDEEEEEFTGFNQE-DLEEEKGETQVKEAEDSDSDDNIKRGKH----------- 522
G+ +E + F E + ++K + + D +++ +K KH
Sbjct: 644 ---GQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKL 700
Query: 523 -MDFLSDFEMMLQRKKSMSGKRRRNRD-GGTFISDADDVVSAMIVK-MNEAAEEDRQLNN 579
L + E + + +KS+ + N+D +F + D A + + E + ++ +L
Sbjct: 701 SKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRL 760
Query: 580 QKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKE 618
K+ KK P+ + KK DLKE I KE
Sbjct: 761 YKEERKKKSKDRPSKLE--KKNDLKEDKISKEKEKIFKE 797
Score = 30.0 bits (66), Expect = 9.1
Identities = 55/263 (20%), Positives = 91/263 (34%), Gaps = 44/263 (16%)
Query: 22 ERDSGSDGEDDVNEQHSGSDTGSVERH---------SENETSDREDGLPKGHHV------ 66
E+ + +D E S D+G E+ S N +D ED L K +
Sbjct: 1369 EKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKK 1428
Query: 67 --TDSEND---------EPLNLNA----SDSESEELHRQK--DSDSESEERAEPPASDSE 109
DSE + +P +A + + E HR+K D +R
Sbjct: 1429 DKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHH 1488
Query: 110 NEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKS-- 167
+++ +H D + TR D ++ + S E +G + + +K
Sbjct: 1489 RDELLRHHRDEQKPATR-----DKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKG 1543
Query: 168 -PASDSETEDALKPQISDSESEEPPRHQA-SDSENEEPPKPRM---SDSESEELPKPQVS 222
P S D + P + + PR + D + RM D E EE K
Sbjct: 1544 DPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKE 1603
Query: 223 DSESEEPPRHQASDSENEELPKP 245
+ E RH++ D + +E KP
Sbjct: 1604 RMKQMEKLRHRSGDPKLKEKAKP 1626
>gi|195976782 Paf1/RNA polymerase II complex component [Homo
sapiens]
Length = 710
Score = 79.7 bits (195), Expect = 1e-14
Identities = 77/315 (24%), Positives = 139/315 (44%), Gaps = 39/315 (12%)
Query: 171 DSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPP 230
DS+TED+ + D E + + SDSE +EPP + + S E SDS+ E
Sbjct: 52 DSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSE-----TSDSDDEW-- 104
Query: 231 RHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSE 290
+ N+ K + E + + QA+ + + + S +ES P + SDS+
Sbjct: 105 ----TFGSNKNKKKGKARKIEKKGTMKKQANKTASSG-SSDKDSSAESSAPEEGEVSDSD 159
Query: 291 NEELPKPRVSDSESEGPQ--KGPASD--SETEDASRHKQKPESDDDSDRENKGEDTEMQN 346
+ SDS SE + G D + ED +R +Q E + + + N+ E E+
Sbjct: 160 SNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLK 219
Query: 347 DSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKE-----------GEEEKVAKRKAA 395
F +KK ++ +E++ KK+K + ++++K+ +E+ +KR
Sbjct: 220 RRFEI-----KKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEK 274
Query: 396 VLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEE 455
+ S+ E+ A++ + + ++ ++ K + + SD EEE E DK +E+
Sbjct: 275 LDKKSQAMEELKAEREK----RKNRTAELLAKKQPLKTSEVYSDDEEE---EEDDKSSEK 327
Query: 456 KDLFGSDSESGNEEE 470
D S S EEE
Sbjct: 328 SDRSSRTSSSDEEEE 342
Score = 70.1 bits (170), Expect = 8e-12
Identities = 68/307 (22%), Positives = 131/307 (42%), Gaps = 30/307 (9%)
Query: 221 VSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESED 280
V DS++E+ + D E L K + SDSE ++PP Q + S SDSE+ D
Sbjct: 50 VIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAAS----------SDSETSD 99
Query: 281 PPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGE 340
++ + N+ K + E +G K A+ + + +S ES + E
Sbjct: 100 SD-DEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDS 158
Query: 341 DTEMQNDSFHSDSHMDRKKFHSS------DSEEEEHKKQKMDSDEDEKE----GEEEKVA 390
D+ + S SDS + ++FH EE+ + ++M E E+E E+ +V
Sbjct: 159 DSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVL 218
Query: 391 KRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGK--EL 448
KR+ + + + K + KK + + + +E + S ++E K E
Sbjct: 219 KRRFEI----KKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEK 274
Query: 449 SDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEA 508
DKK++ + ++ E + +N A++ + + E ++E+ E++K + +
Sbjct: 275 LDKKSQAMEELKAERE---KRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRS 331
Query: 509 EDSDSDD 515
+ S D
Sbjct: 332 SRTSSSD 338
Score = 66.2 bits (160), Expect = 1e-10
Identities = 77/359 (21%), Positives = 140/359 (38%), Gaps = 46/359 (12%)
Query: 62 KGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEE-RAEPPASDSENEDVNQHGSDS 120
KG V DS+ ++ + D E L ++K SDSE +E PA+ S++E SDS
Sbjct: 46 KGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSET-----SDS 100
Query: 121 ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP 180
+ E T N+ G A E + K A+ K+ +S S +D
Sbjct: 101 DDEWT------FGSNKNKKKGKARKIEKKGTMKKQAN--------KTASSGSSDKD---- 142
Query: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE 240
S +ES P + SDS++ SDS SE+ EE D +
Sbjct: 143 --SSAESSAPEEGEVSDSDSNSSSSSSDSDSSSED-----------EEFHDGYGEDLMGD 189
Query: 241 ELPKPRISDSESEDPPRHQASDSENEELPKPRI---------SDSESEDPPRNQASDSEN 291
E + R+ ++ + + E E+ K R E ++ + Q + E
Sbjct: 190 EEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEK 249
Query: 292 EELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHS 351
++L + + S S ++ D + + S+ ++ +++ + + E + S
Sbjct: 250 KKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTS 309
Query: 352 DSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKK 410
+ + D ++ D E+ + S DE+E +EE K + L + + + S K
Sbjct: 310 EVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHK 368
Score = 62.4 bits (150), Expect = 2e-09
Identities = 70/313 (22%), Positives = 118/313 (37%), Gaps = 52/313 (16%)
Query: 145 DSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSE----- 199
DS+ ED G D E+ L K SDSE ++ P +S + SD E
Sbjct: 52 DSDTEDSGSDENLDQELLSLAKRKRSDSEEKE---PPVSQPAASSDSETSDSDDEWTFGS 108
Query: 200 NEEPPKPRMSDSESEELPKPQV------------SDSESEEPPRHQASDSENEELPKPRI 247
N+ K + E + K Q S +ES P + SDS++
Sbjct: 109 NKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSD 168
Query: 248 SDSESEDPPRHQA--SDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESE 305
SDS SED H D +E + R+ ++ + + E E+ K R
Sbjct: 169 SDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEI---- 224
Query: 306 GPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDS 365
K ++ ++ K+K E + + + + +++++ + + S D K S +
Sbjct: 225 ---KKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQA 281
Query: 366 EEE---EHKKQKM--------------------DSDEDEKEGEEEKVAKRKAAVLSDSED 402
EE E +K+K D +E+E + EK + SD E+
Sbjct: 282 MEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEE 341
Query: 403 EEKASAKKSRVVS 415
E++ KS+ VS
Sbjct: 342 EKEEIPPKSQPVS 354
Score = 52.8 bits (125), Expect = 1e-06
Identities = 61/304 (20%), Positives = 128/304 (42%), Gaps = 31/304 (10%)
Query: 299 VSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRK 358
++ + P G T + K + D D++ E+ + + S D +
Sbjct: 21 LAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSE 80
Query: 359 K-------------FHSSDSEEE-----EHKKQKMDSDEDEKEGEEEKVAKRKAAV-LSD 399
+ +SDS++E K+K + + EK+G +K A + A+ SD
Sbjct: 81 EKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSD 140
Query: 400 SEDEEKASAKKSRVVSDADDSDSDAVSDKSGKRE---------KTIASDSEEEAGKELSD 450
+ ++SA + VSD+D + S + SD E + + D E+ A E
Sbjct: 141 KDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMT 200
Query: 451 KKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAED 510
+K E++LF + + ++ ++E++ QE+ +E+K TQ++E++
Sbjct: 201 EKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQV 260
Query: 511 SDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEA 570
+ S + +R K + L ++ K+ ++R+NR ++ + ++ + +E
Sbjct: 261 T-SHNKERRSKRDEKLDKKSQAMEELKA-EREKRKNRT-AELLAKKQPLKTSEVYSDDEE 317
Query: 571 AEED 574
EED
Sbjct: 318 EEED 321
Score = 52.8 bits (125), Expect = 1e-06
Identities = 55/302 (18%), Positives = 124/302 (41%), Gaps = 24/302 (7%)
Query: 27 SDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEP-------LNLNA 79
SD ED ++++ + S+ + +++ ++E + + +DSE + N N
Sbjct: 53 SDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNK 112
Query: 80 SDSESEELHRQKDSDSESEERAEPPASDSEN-------EDVNQHGSDSESEETRKLPGSD 132
++ ++ ++ ++ + A +SD ++ E+ SDS S + S
Sbjct: 113 KKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSS 172
Query: 133 SENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQI-------SDS 185
SE+EE +G+ D ++ + +E ++ + E + LK + +
Sbjct: 173 SEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAK 232
Query: 186 ESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKP 245
+ E+ + + + E E+ ++ +S+ K + S + + + QA + E K
Sbjct: 233 KKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKR 292
Query: 246 RISDSE---SEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDS 302
+ +E + P + S++EE + S +S+ R +SD E E+ P S
Sbjct: 293 KNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQP 352
Query: 303 ES 304
S
Sbjct: 353 VS 354
Score = 48.9 bits (115), Expect = 2e-05
Identities = 65/307 (21%), Positives = 122/307 (39%), Gaps = 23/307 (7%)
Query: 10 QSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDS 69
+SD P + + SD E ++ + ++ + +++ + K + T S
Sbjct: 76 RSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTAS 135
Query: 70 ENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQ-HGSD---SESEET 125
+ +A S EE DSDS S + S SE+E+ + +G D E +
Sbjct: 136 SGSSDKDSSAESSAPEE-GEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRA 194
Query: 126 RKLPGSDSENEELLNGHASDSE----NEDVGKHPASDSEIEELQKSPASDSETEDALKPQ 181
R ++ E E+ L E ++ K + + E+ +K + E E Q
Sbjct: 195 RLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQ 254
Query: 182 ISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSE---SEEPPRHQASDSE 238
I +S+ + + S + + K + + E K + +E ++P + S+
Sbjct: 255 IQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSD 314
Query: 239 NEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPR 298
+EE + S +S+ R +SD E E + E PP++Q S EEL + R
Sbjct: 315 DEEEEEDDKSSEKSDRSSRTSSSDEEEE----------KEEIPPKSQPV-SLPEELNRVR 363
Query: 299 VSDSESE 305
+S + E
Sbjct: 364 LSRHKLE 370
Score = 41.2 bits (95), Expect = 0.004
Identities = 47/248 (18%), Positives = 97/248 (39%), Gaps = 11/248 (4%)
Query: 9 DQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTD 68
+++ G++ +S + E +V++ S S + S + S +E + DG G +
Sbjct: 131 NKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGY--GEDLMG 188
Query: 69 SENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKL 128
E D A + E R+++ + E+R E E + + E +E +K
Sbjct: 189 DEEDR-----ARLEQMTEKEREQELFNRIEKR-EVLKRRFEIKKKLKTAKKKEKKEKKKK 242
Query: 129 PGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESE 188
+ E ++L S + + + D ++++ ++ + K + ++ ++
Sbjct: 243 QEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAK 302
Query: 189 EPPRHQA---SDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKP 245
+ P + SD E EE S+ + E EE P S EEL +
Sbjct: 303 KQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRV 362
Query: 246 RISDSESE 253
R+S + E
Sbjct: 363 RLSRHKLE 370
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 79.7 bits (195), Expect = 1e-14
Identities = 96/427 (22%), Positives = 158/427 (37%), Gaps = 42/427 (9%)
Query: 51 NETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQ--KDSDSESEERA------- 101
N+ +GL + + + P +++SDSE+ E + D+D + E+R
Sbjct: 72 NKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAV 131
Query: 102 -EPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSE 160
ASD D + S S RK P + +SD + V S SE
Sbjct: 132 TATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASV-----SPSE 186
Query: 161 IEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQ 220
E + S S+ ++ P+ + P R + ++ P SDS+++
Sbjct: 187 EENSESSSESEKTSDQDFTPE-KKAAVRAPRRGPLGGRKKKKAPSASDSDSKAD------ 239
Query: 221 VSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESED 280
SD EP S S + SD + PPR + + LPKPR + E
Sbjct: 240 -SDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKP--AEKPLPKPRGRKPKPER 296
Query: 281 PPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQ-----------KPES 329
PP + +SDS+++E+ D SE ++ A E E R +Q K E
Sbjct: 297 PPSSSSSDSDSDEV------DRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEK 350
Query: 330 DDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKV 389
+ +R ++GE S + D + + E E E E E
Sbjct: 351 ERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAK 410
Query: 390 AKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELS 449
K S +E K K+ RV + +++ KR + + D + E KE S
Sbjct: 411 KSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPS 470
Query: 450 DKKNEEK 456
++ +K
Sbjct: 471 VEEKLQK 477
Score = 57.0 bits (136), Expect = 7e-08
Identities = 122/591 (20%), Positives = 229/591 (38%), Gaps = 82/591 (13%)
Query: 163 ELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVS 222
E+Q +P + P +S S+SE P + A S+ +E + R + + + S
Sbjct: 83 EIQNNPHASYSAP----PPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTA-VTATAAS 137
Query: 223 DSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPP 282
D + ++SD+ + P + S S+ R +SD L + +S SE E+
Sbjct: 138 DRMESDSDSDKSSDNSGLKRKTPALKMSVSKRA-RKASSD-----LDQASVSPSEEENSE 191
Query: 283 RNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDT 342
+ S+ +++ P + P++GP R K+K S DSD + +
Sbjct: 192 SSSESEKTSDQDFTPE-KKAAVRAPRRGPLG-------GRKKKKAPSASDSDSKADSDGA 243
Query: 343 EMQNDSFHSDSHMDRKKFHSSDSEEEEHK----KQKMDSDEDEKEGEEEKVAKRKAAVLS 398
+ + + + SSDS+ K ++ + + G + K + ++ S
Sbjct: 244 KPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSS 303
Query: 399 DSEDEE--KASAKKSRVVSDADDSDSDAVSDKSGKRE-KTIASDSEEEAGKELSDKKNEE 455
DS+ +E + S K R D++ +RE + +EE + L +++ EE
Sbjct: 304 DSDSDEVDRISEWKRR--------------DEARRRELEARRRREQEEELRRLREQEKEE 349
Query: 456 KDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLE-EEKGETQVKEAE-DSDS 513
K+ ++ G E G SGDE E+ + + +G ++E +++
Sbjct: 350 KERRRERADRGEAERG----SGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAEL 405
Query: 514 DDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEE 573
+ K+ S E RK KR R + A V K +E
Sbjct: 406 EREAKKSAKKPQSSSTEP--ARKPGQKEKRVRPEEK----QQAKPVKVERTRKRSEGFSM 459
Query: 574 DRQLNNQKKPAL-KKLTLLPAVVMHLKKQDLKE------TFIDSGVMSAIKEWLSPLPDR 626
DR++ +K+P++ +KL L + + K D + + G + + L D
Sbjct: 460 DRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDV 519
Query: 627 SLPALKIRE-ELLKILQELPSVSQETLKHSGIGRAVMYLYKHPK---------ESRSNKD 676
KIR + K + E + LK +G + + K K E + ++
Sbjct: 520 VATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEE 579
Query: 677 MAG----------KLINEWSRPIFGLTSNYKGMTREEREQ---RDLEQMPQ 714
+AG K + S P+ G ++ KG + E++E RD E+ P+
Sbjct: 580 LAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPR 630
Score = 33.9 bits (76), Expect = 0.63
Identities = 66/335 (19%), Positives = 122/335 (36%), Gaps = 62/335 (18%)
Query: 30 EDDVNEQHSGSDTGSVERHSENETSD--REDGLPKGHHVTDSENDEPLNLNASDSESEEL 87
+++ + +D G ER S + D RED P P + + S+ E+E
Sbjct: 347 KEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELE 406
Query: 88 HRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSE 147
K S + + + PA ++ + + + K+ + +E G + D +
Sbjct: 407 REAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSE----GFSMDRK 462
Query: 148 NEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSES-------------------- 187
E K P+ + ++++L SE + ALK D +
Sbjct: 463 VEKK-KEPSVEEKLQKLH------SEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQK 515
Query: 188 --------EEPPRHQASDSENEEPP------KPRMSDSESEELPKPQVSDSESEEPPRHQ 233
++ R++A+ E+ K R+ + E + K + E E+
Sbjct: 516 NTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKL 575
Query: 234 ASDS-ENEELPKPRISDSESED---PPRHQASDSENEELP-KPRISDSESEDPPRNQASD 288
A + EE P+ + D S D P +A+ + E K +SE+ PR +S+
Sbjct: 576 AGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSE 635
Query: 289 SENEELPKPRVSDSESEGPQ-KGPASDSETEDASR 322
+ DS EGP P SD + + +R
Sbjct: 636 D---------LHDSVREGPDLDRPGSDRQERERAR 661
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 79.7 bits (195), Expect = 1e-14
Identities = 96/427 (22%), Positives = 158/427 (37%), Gaps = 42/427 (9%)
Query: 51 NETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQ--KDSDSESEERA------- 101
N+ +GL + + + P +++SDSE+ E + D+D + E+R
Sbjct: 72 NKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAV 131
Query: 102 -EPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSE 160
ASD D + S S RK P + +SD + V S SE
Sbjct: 132 TATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASV-----SPSE 186
Query: 161 IEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQ 220
E + S S+ ++ P+ + P R + ++ P SDS+++
Sbjct: 187 EENSESSSESEKTSDQDFTPE-KKAAVRAPRRGPLGGRKKKKAPSASDSDSKAD------ 239
Query: 221 VSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESED 280
SD EP S S + SD + PPR + + LPKPR + E
Sbjct: 240 -SDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKP--AEKPLPKPRGRKPKPER 296
Query: 281 PPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQ-----------KPES 329
PP + +SDS+++E+ D SE ++ A E E R +Q K E
Sbjct: 297 PPSSSSSDSDSDEV------DRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEK 350
Query: 330 DDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKV 389
+ +R ++GE S + D + + E E E E E
Sbjct: 351 ERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAK 410
Query: 390 AKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELS 449
K S +E K K+ RV + +++ KR + + D + E KE S
Sbjct: 411 KSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPS 470
Query: 450 DKKNEEK 456
++ +K
Sbjct: 471 VEEKLQK 477
Score = 57.0 bits (136), Expect = 7e-08
Identities = 122/591 (20%), Positives = 229/591 (38%), Gaps = 82/591 (13%)
Query: 163 ELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVS 222
E+Q +P + P +S S+SE P + A S+ +E + R + + + S
Sbjct: 83 EIQNNPHASYSAP----PPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTA-VTATAAS 137
Query: 223 DSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPP 282
D + ++SD+ + P + S S+ R +SD L + +S SE E+
Sbjct: 138 DRMESDSDSDKSSDNSGLKRKTPALKMSVSKRA-RKASSD-----LDQASVSPSEEENSE 191
Query: 283 RNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDT 342
+ S+ +++ P + P++GP R K+K S DSD + +
Sbjct: 192 SSSESEKTSDQDFTPE-KKAAVRAPRRGPLG-------GRKKKKAPSASDSDSKADSDGA 243
Query: 343 EMQNDSFHSDSHMDRKKFHSSDSEEEEHK----KQKMDSDEDEKEGEEEKVAKRKAAVLS 398
+ + + + SSDS+ K ++ + + G + K + ++ S
Sbjct: 244 KPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSS 303
Query: 399 DSEDEE--KASAKKSRVVSDADDSDSDAVSDKSGKRE-KTIASDSEEEAGKELSDKKNEE 455
DS+ +E + S K R D++ +RE + +EE + L +++ EE
Sbjct: 304 DSDSDEVDRISEWKRR--------------DEARRRELEARRRREQEEELRRLREQEKEE 349
Query: 456 KDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLE-EEKGETQVKEAE-DSDS 513
K+ ++ G E G SGDE E+ + + +G ++E +++
Sbjct: 350 KERRRERADRGEAERG----SGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAEL 405
Query: 514 DDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEE 573
+ K+ S E RK KR R + A V K +E
Sbjct: 406 EREAKKSAKKPQSSSTEP--ARKPGQKEKRVRPEEK----QQAKPVKVERTRKRSEGFSM 459
Query: 574 DRQLNNQKKPAL-KKLTLLPAVVMHLKKQDLKE------TFIDSGVMSAIKEWLSPLPDR 626
DR++ +K+P++ +KL L + + K D + + G + + L D
Sbjct: 460 DRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDV 519
Query: 627 SLPALKIRE-ELLKILQELPSVSQETLKHSGIGRAVMYLYKHPK---------ESRSNKD 676
KIR + K + E + LK +G + + K K E + ++
Sbjct: 520 VATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEE 579
Query: 677 MAG----------KLINEWSRPIFGLTSNYKGMTREEREQ---RDLEQMPQ 714
+AG K + S P+ G ++ KG + E++E RD E+ P+
Sbjct: 580 LAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPR 630
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 79.3 bits (194), Expect = 1e-14
Identities = 122/559 (21%), Positives = 222/559 (39%), Gaps = 79/559 (14%)
Query: 9 DQSDDGGATPVQDERDSGSDGE-DDVNEQHSGSDTGS-VERHSEN----ETSDREDGLPK 62
++S + + ++++R S G ++ E+ S GS ++ HS N ++ + P+
Sbjct: 545 NESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPE 604
Query: 63 GHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSES 122
+ +N + A DS E H ++D ++ ER + P+S ++ N E
Sbjct: 605 RDRYPERDNRD----QARDSSFERRHGERDR-RDNRERDQRPSSPIRHQGRNDELERDER 659
Query: 123 EETRKLPGSDSENEELLNGHASDSENE---DVGKHPASDSEIE---ELQKSPASDSETE- 175
E R++ D +E + E + + + D E E EL++ A + E E
Sbjct: 660 REERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERER 719
Query: 176 ----DALKPQISDSESE-----EPPRHQASDSENEEPPKPRMSDSESE-----ELPKPQV 221
D + + D + E E R + + E EE + R + E E E + +
Sbjct: 720 EKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARE 779
Query: 222 SDSESEEPPRHQASDSENEELPKPRISDSESEDP-----PRHQASDSENEELPKPRISDS 276
D E E + D ++ + R E +P R NE P PR S
Sbjct: 780 RDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPK 839
Query: 277 E----SEDPPRNQASDSENE------ELPKPRVSDSES--------EGPQKGPASDSETE 318
S D + D +NE ++ +P+ S S S +G K E +
Sbjct: 840 RRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERK 899
Query: 319 DASRHKQKPESDDD-SDRENKGEDTEMQNDSFHSDS----HMDRKKFHSSDSEEEEHKKQ 373
++SR ++ E + S + + E TE+ S H + +SD +E+KK+
Sbjct: 900 ESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKK 959
Query: 374 KMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKRE 433
+ K+ +E+ V + + + SED + S KK + +K K+
Sbjct: 960 AKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSI---------EKKRKKS 1010
Query: 434 KTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESG---DEEEEEFTG 490
K + S+EEA ++ K+ G + +E L+ G++G D +++E T
Sbjct: 1011 KGDSDISDEEAAQQSKKKR-------GPRTPPITTKEELVEMCNGKNGILEDSQKKEDTA 1063
Query: 491 FNQEDLEEEKGETQVKEAE 509
F+ E+ T+V EAE
Sbjct: 1064 FSDWSDEDVPDRTEVTEAE 1082
Score = 70.1 bits (170), Expect = 8e-12
Identities = 108/574 (18%), Positives = 200/574 (34%), Gaps = 63/574 (10%)
Query: 38 SGSDTGS-VERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSE 96
S S +GS ++RHS + R +T PL +AS S L S
Sbjct: 334 SSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTP-----PLRRSASPYPSHSL-------SS 381
Query: 97 SEERAEPPASDSENEDVNQHGSD--SESEETRKLPGSDSENEELLNGHASDSENEDVGKH 154
+ + PP S + +H + S+S + R D+ + DS E +
Sbjct: 382 PQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKR---DREKDSREEREYEQ 438
Query: 155 PASDSEIEELQKSPASDSETEDAL----KPQISDSESEEPPRHQ---ASDSENEEPPKPR 207
S S + P + DA + ++ DS R + D++ P+
Sbjct: 439 DQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDS 498
Query: 208 MSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEE 267
S ++ + + D+ +E E+ + + + S R+++ + E
Sbjct: 499 RSTRDAHDYRDREGRDTHRKE----DTYPEESRSYGRNHLREESSRTEIRNESRNESRSE 554
Query: 268 LPKPRISDSESEDPP---------RNQASDSENEELPKPRVSDSESEGPQKGPASDSETE 318
+ R+ S P R DS + ++ S P++ + +
Sbjct: 555 IRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNR 614
Query: 319 DASRHKQKPESDDDSDRENKGEDTEM---------QNDSFHSDSHMDRKKFHSSDSEEEE 369
D +R + DR + E + +ND D + ++ D +E
Sbjct: 615 DQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDE 674
Query: 370 HKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKS 429
+++ E ++E E E+ +R + E E + + ++ R D + D D
Sbjct: 675 RARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHD 734
Query: 430 GKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFT 489
+RE+ D E+E +E +++ E + + E E E D+E E
Sbjct: 735 RERERERERDREKEREREREERERERERERERERERERERER------ARERDKERE--- 785
Query: 490 GFNQEDLEE-EKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKS--MSGKRRRN 546
Q D E+ +KG +E + +D R H + S + S S KRRR
Sbjct: 786 --RQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRRE 843
Query: 547 R--DGGTFISDADDVVSAMIVKMNEAAEEDRQLN 578
D + S D ++ +E R L+
Sbjct: 844 HSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLS 877
Score = 65.5 bits (158), Expect = 2e-10
Identities = 67/341 (19%), Positives = 139/341 (40%), Gaps = 27/341 (7%)
Query: 186 ESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKP 245
E E P D+++ +P + S S + P A S +++ +
Sbjct: 1166 EKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRK 1225
Query: 246 RISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESE 305
R+ S S D + ++ + E K RI + +P R+ +SD ++ R S ES+
Sbjct: 1226 RVLHSGSRDREKTKSLEITGER--KSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESD 1283
Query: 306 GPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDS----HMDRKKFH 361
+ ++ D + + + E D + +RE + DT + +D + DR +
Sbjct: 1284 RQVHSRSGSFDSRDRLQERDRYEHDRERERERR--DTRQREWDRDADKDWPRNRDRDRLR 1341
Query: 362 SSDSEEEEHKKQKMD-------SDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAK-KSRV 413
+ E E K++ +D SD E++ + + + + S E ++ AK +
Sbjct: 1342 ERERERERDKRRDLDRERERLISDSVERDRDRD---RDRTFESSQIESVKRCEAKLEGEH 1398
Query: 414 VSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLI 473
D + + D+++ + +K + S G E ++K + L D ES ++ + +
Sbjct: 1399 ERDLESTSRDSLALDKERMDKDLGS----VQGFEETNKSERTESLEAGDDESKLDDAHSL 1454
Query: 474 ADIFGES----GDEEEEEFTGFNQEDLEEEKGETQVKEAED 510
GE D+E +E + E E+++ E ++ + D
Sbjct: 1455 GSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPLD 1495
Score = 60.1 bits (144), Expect = 8e-09
Identities = 107/538 (19%), Positives = 184/538 (34%), Gaps = 79/538 (14%)
Query: 42 TGSVERHSENETSDREDGLPKGHHVTDSE----NDEPLNLNASDSESEELHRQKDSDSES 97
+ + R E T D + + D+E N E + S HR+K+ +
Sbjct: 71 SSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKIT 130
Query: 98 EERAEPPASDSENEDV----NQHGSDS----------------ESEETRKLPGSDSENEE 137
+ER +SE E+V N+ SD+ + R+L + EN E
Sbjct: 131 KERTP----ESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENME 186
Query: 138 -----LLNGHASD-------SENEDVGKHPASDSEIEELQKSPAS--DSETEDALKPQIS 183
++ S S + + K S + S AS D +T P +
Sbjct: 187 KREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLD 246
Query: 184 DSESEEPPRHQASDSENEEPPKPRMSD------SESEELPKPQVSDSESEEPPRHQASDS 237
+ + + + PP P D + + K ++ + + R + +
Sbjct: 247 QQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFER 306
Query: 238 ENEELPKPR----ISDSESEDPPRHQASDSEN-----EELPKPRISDSESEDPPRNQASD 288
+ E+ KPR S RH +S S++ P PR + S R
Sbjct: 307 QREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPP 366
Query: 289 SENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDS 348
P P S S + Q P S + RH + S R + EDT + D
Sbjct: 367 LRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDR 426
Query: 349 FHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAK--RKAAVLSDSEDEEKA 406
DS +R ++ S +H+ D + ++G + + A+ R L DS D
Sbjct: 427 -EKDSREER-EYEQDQSSSRDHR-----DDREPRDGRDRRDARDTRDRRELRDSRD---- 475
Query: 407 SAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESG 466
+ SR + D D+ D R A D + G++ K++ + S +
Sbjct: 476 -MRDSREMRDY-SRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNH 533
Query: 467 NEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMD 524
EE+ +I ES +E E + G ++ + E + RG +D
Sbjct: 534 LREESSRTEIRNESRNESRSEIR-------NDRMGRSRGRVPELPEKGSRGSRGSQID 584
Score = 33.9 bits (76), Expect = 0.63
Identities = 61/280 (21%), Positives = 106/280 (37%), Gaps = 38/280 (13%)
Query: 204 PKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQAS-- 261
P PR S P+ + E +++ D + E P+ R ++ ES P R ++S
Sbjct: 63 PSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTE--PQKRNTE-ESSSPVRKESSRG 119
Query: 262 ---DSENEELPKPRISDSESEDPP-RNQASDSENEELPKPRVSDSESEGPQKGPASDSET 317
+ E+ ++ K R +SE E+ DS+N ++ V + E +
Sbjct: 120 RHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLE---------MKR 170
Query: 318 EDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDS 377
+ R K E ++ RE E+ + + R K S S + K K S
Sbjct: 171 QKIQRELMKLEQENMEKREEIIIKKEVSPE-------VVRSKLSPSPSLRKSSKSPKRKS 223
Query: 378 DEDEKEGEEEKVAKRKAAVLSDSEDEEKAS------AKKSRVVSDADDSDSDAVSDKSGK 431
K K ++ +AV S D+++ S K R S D K K
Sbjct: 224 --SPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYK 281
Query: 432 REKTIASDSEEEA--GKELS---DKKNEEKDLFGSDSESG 466
+ + EE+ GK+ +++ E++D S S +G
Sbjct: 282 EKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAG 321
Score = 32.7 bits (73), Expect = 1.4
Identities = 66/341 (19%), Positives = 113/341 (33%), Gaps = 44/341 (12%)
Query: 21 DERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHH--------------- 65
D++ S S G + N H+ S S + + D + G + H
Sbjct: 1185 DQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEIT 1244
Query: 66 ------VTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSD 119
+ + EP +SD + H + S ES+ + + ++ D Q
Sbjct: 1245 GERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDR 1304
Query: 120 SESEETRKLPGSDSENEELLNGHASD-SENEDVGKHPASDSEIEELQKSPASDSETEDAL 178
E + R+ D+ E D N D + + E E K D E E
Sbjct: 1305 YEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERE-RERDKRRDLDRERERL- 1362
Query: 179 KPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSE 238
ISDS + R + R +S E K + E E +++ +
Sbjct: 1363 ---ISDSVERDRDR-----------DRDRTFESSQIESVKRCEAKLEGEHERDLESTSRD 1408
Query: 239 NEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPR 298
+ L K R+ + + SE E + +S+ +D + E E
Sbjct: 1409 SLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYE----P 1464
Query: 299 VSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKG 339
+SD E + G A + ED ++ P+ D D + G
Sbjct: 1465 ISDDELDEILAGDA--EKREDQQDEEKMPDPLDVIDVDWSG 1503
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 78.6 bits (192), Expect = 2e-14
Identities = 107/547 (19%), Positives = 193/547 (35%), Gaps = 89/547 (16%)
Query: 22 ERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASD 81
++ S SD ED E+ + + + GLP G + ++ D
Sbjct: 80 KKASSSDSEDSSEEEEEVQGPPA----KKAAVPAKRVGLPPGKAAAKASESSSSEESSDD 135
Query: 82 SESEELHRQ----------------------KDSDSESEERAEPPASDSENEDVNQHGSD 119
+ E+ +Q DSDS+S EPP +
Sbjct: 136 DDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT-----PV 190
Query: 120 SESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSP----------- 168
+ +T+ P ++ NG A+ S + + DSE E+ +P
Sbjct: 191 TVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVA 250
Query: 169 -----ASDSETEDALKPQISDSESEE---------PPRHQASDSENEEPPKPRMSDSESE 214
A+ + T + + S S+ EE P + + + PPK + +
Sbjct: 251 KAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK 310
Query: 215 ELPKPQVSDSESEEPPRHQASDSENEELP--KPRISDSESEDPPRHQASDSENEELPKPR 272
+ + Q SE+ S SE E+ P K +S + ++ PP +A++S ++
Sbjct: 311 KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDS 370
Query: 273 ISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHK---QKPES 329
D E+ P +S N KP V+ ++ P PA+ + K +K +S
Sbjct: 371 SEDDEAPSKPAGTTKNSSN----KPAVT---TKSPAVKPAAAPKQPVGGGQKLLTRKADS 423
Query: 330 DDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEK- 388
+ + E+ + + + K S +++ + SD D EEE+
Sbjct: 424 SSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEE 483
Query: 389 ------VAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEE 442
V K+ V + + ASAKK + S ++ S SD S++ ++ K S +
Sbjct: 484 KTSKSAVKKKPQKVAGGAAPSKPASAKKGKAES-SNSSSSDDSSEEEEEKLKGKGSPRPQ 542
Query: 443 EAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGE 502
+ + +SE EE+ A + +SG L++ K
Sbjct: 543 APKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSG-------------SLKKRKQN 589
Query: 503 TQVKEAE 509
KEAE
Sbjct: 590 EAAKEAE 596
Score = 67.8 bits (164), Expect = 4e-11
Identities = 86/410 (20%), Positives = 158/410 (38%), Gaps = 68/410 (16%)
Query: 89 RQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSEN 148
R+ ++ ++A+ AS S++ED ++ + + +K ++ L G A+ +
Sbjct: 66 RKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKA-AVPAKRVGLPPGKAAAKAS 124
Query: 149 EDVGKHPASDSEIEELQKS--------PASDSETEDALKPQISDSESE-----EPPRHQA 195
E +SD + EE QK P + + K + SDS+S+ EPP++Q
Sbjct: 125 ESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQK 184
Query: 196 SD-------SENEEPPKP-----RMSDSESEELPKPQVSDSESEEPPRHQASDSENEELP 243
++ + PPKP ++++ ++ S S S++ +A+ + + +P
Sbjct: 185 PKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVP 244
Query: 244 KPRI---SDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS 300
K ++ + ++ P ++S SE+ SD E E + +P P
Sbjct: 245 KKQVVAKAPVKAATTPTRKSSSSEDSS------SDEEEEQKKPMKNKPGPYSSVPPP--- 295
Query: 301 DSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF 360
S P K + A +Q ES +DS E+
Sbjct: 296 ---SAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDES----------------------- 329
Query: 361 HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS 420
S SEEE+ K + + K A ++ SDS+ E A + + S
Sbjct: 330 -DSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSS 388
Query: 421 DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEE 470
+ AV+ KS + A G++L +K D S+ ES + EE
Sbjct: 389 NKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRK---ADSSSSEEESSSSEE 435
Score = 66.6 bits (161), Expect = 9e-11
Identities = 98/473 (20%), Positives = 173/473 (36%), Gaps = 59/473 (12%)
Query: 27 SDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEE 86
++G+ + S S + S + E + + +PK V + S SE+
Sbjct: 210 ANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSED 269
Query: 87 LHRQKDSDSESEER------------AEPPASDSENEDVNQHGSDSESEETRKLPGSDSE 134
SD E E++ PP++ + + E+ + + S+
Sbjct: 270 ----SSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDS 325
Query: 135 NEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDS-ESEEPPRH 193
++E SDS +E+ K P + K P + E + SDS E +E P
Sbjct: 326 SDE------SDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK 379
Query: 194 QASDSENEEPPKPRMSDS----ESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISD 249
A ++N KP ++ + PK V + + +S SE E
Sbjct: 380 PAGTTKNSSN-KPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKT 438
Query: 250 SESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQK 309
+ + +A+ LP + + + +S SE EE + + + PQK
Sbjct: 439 KKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEE--EKTSKSAVKKKPQK 496
Query: 310 GPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSD-------------SHMD 356
+ ++ AS K K ES + S ++ E+ E + S + +
Sbjct: 497 VAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQN 556
Query: 357 RKKFHSSDSEEEEHKK-----------QKMDSDEDEKEGEEEKVAKRKAAVLSD----SE 401
K +S+ EEEE KK +K +E KE E + K K + +
Sbjct: 557 GKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKK 616
Query: 402 DEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNE 454
E++AS+ RV + + DS V+D S ++ A D E A + L K +
Sbjct: 617 GEKRASSPFRRVREEEIEVDS-RVADNSFDAKRGAAGDWGERANQVLKFTKGK 668
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 78.2 bits (191), Expect = 3e-14
Identities = 92/507 (18%), Positives = 207/507 (40%), Gaps = 45/507 (8%)
Query: 36 QHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDS 95
+H + +++ ++ D + G P N + E+ RQ ++D
Sbjct: 101 RHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADK 160
Query: 96 ESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHP 155
+ + +++ ++ +S++ +T S + ++ N +++E +P
Sbjct: 161 TPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNP 220
Query: 156 ASDSEIEELQKSPASDSETEDALKPQI------SDSESEEPP----RHQASDSENEEPPK 205
D + + P S+ +E++L SD ES + ++S+N
Sbjct: 221 KKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKY 280
Query: 206 PRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSEN 265
+ + ++++ K SD+ESE+ + + +++++ K D + +D + S
Sbjct: 281 TKYTKKDTKKNAKKS-SDAESEDS---KDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAE 336
Query: 266 EELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQ 325
K D++ +D + + D + + P +D+ES G A D+ + SR+ +
Sbjct: 337 SGDSKDERKDTK-KDKKKLKKDDKKKDTKKYPESTDTES-----GDAKDARND--SRNLK 388
Query: 326 KPESDDDSDRENK------GEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDE 379
K +DD ++ K ++E+++ D D+K + + + ++ ++ D+D
Sbjct: 389 KASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADS 448
Query: 380 DEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASD 439
+ K ++ K +D++K AKK+ +++ + +SD K K
Sbjct: 449 EPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN---AESTEMESDLELKKDKKH------- 498
Query: 440 SEEEAGKELSDKKNEEKDLFGSDS---ESGNEEENLIADIFGESGDEEEEEFTGFNQEDL 496
S+E+ G + KK+ KD +D+ ES I G + EE + ++ +
Sbjct: 499 SKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKI 558
Query: 497 EEEKGETQVKEAEDSDSDDNIKRGKHM 523
+E G + + E +S KRG M
Sbjct: 559 DESDGTSANSKMEGLES----KRGFRM 581
Score = 50.4 bits (119), Expect = 6e-06
Identities = 68/309 (22%), Positives = 119/309 (38%), Gaps = 37/309 (11%)
Query: 10 QSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRED------GLPKG 63
+S D + +DER + + + DT ++ E+ D +D L K
Sbjct: 331 ESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKA 390
Query: 64 HHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESE 123
D + D ++DSESE ++ D + +++ DS+ ++ +D ES
Sbjct: 391 SKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKK------DSKTDNKKSVKNDEEST 444
Query: 124 ETRKLPGSDS-ENEELLNGHASDSENEDVGKHPASDSEIEELQK----------SPASDS 172
+ P DS + ++ DS+ +D K ++E E++ S
Sbjct: 445 DADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKG 504
Query: 173 ETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEE-LPKPQVSDSESEEPPR 231
+D K D+ES + ++S + + K + SD+ESEE L KP E
Sbjct: 505 SKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGT 564
Query: 232 HQASDSENEELPKP-RISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSE 290
S E E + R+S ++ + + E+ R+ S E PP S
Sbjct: 565 SANSKMEGLESKRGFRMSSKKT-------TFNEKGEKASTGRVPPSR-EKPPLPACEPS- 615
Query: 291 NEELPKPRV 299
LP P+V
Sbjct: 616 ---LPSPKV 621
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 77.4 bits (189), Expect = 5e-14
Identities = 84/364 (23%), Positives = 149/364 (40%), Gaps = 51/364 (14%)
Query: 153 KHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSE 212
K +EI+ L+ S DS+ + + ++ D E R+ S E+ + R + +
Sbjct: 24 KEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRN--SPYRREDSMEDRGEEDD 81
Query: 213 SEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRH-QASDSENEELPKP 271
S + PQ +E H+ + E+ R+ + E E RH + D E +
Sbjct: 82 SLAIKPPQ--QMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQ 139
Query: 272 RISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDD 331
+ + E R + E+L + R + + QK E E + ++K +
Sbjct: 140 KRREMAREHSRRER---DRLEQLERKRERERKMREQQKEQREQKERERRAEERRK---ER 193
Query: 332 DSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAK 391
++ RE M+ D + D+ K +++ + + K +EEK+ +
Sbjct: 194 EARREVSAHHRTMRED------YSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEE 247
Query: 392 RKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDK 451
R +LSD +D +SD++ S A S S +E +G E ++
Sbjct: 248 RD--LLSDLQD-----------ISDSERKTSSAES-----------SSAESGSGSEEEEE 283
Query: 452 KNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDS 511
+ EE++ GS SE EE E +EEEEE TG N E+ E+ E +V E E S
Sbjct: 284 EEEEEEEEGSTSEESEEE---------EEEEEEEEEETGSNSEEASEQSAE-EVSEEEMS 333
Query: 512 DSDD 515
+ ++
Sbjct: 334 EDEE 337
Score = 59.3 bits (142), Expect = 1e-08
Identities = 71/360 (19%), Positives = 138/360 (38%), Gaps = 43/360 (11%)
Query: 121 ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIE-ELQKSP-ASDSETEDAL 178
+ ++ RK +E + L N DS+ + + + D +E ++ SP + ED
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMED-- 75
Query: 179 KPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRH-QASDS 237
+ + DS + +PP+ + +E R + E+ +V + E E RH + D
Sbjct: 76 RGEEDDSLAIKPPQQMS----RKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDK 131
Query: 238 ENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKP 297
E + + + E R + E+L + R + + + + Q E E +
Sbjct: 132 ARREWERQKRREMAREHSRRER---DRLEQLERKRERERKMREQQKEQREQKERERRAEE 188
Query: 298 RVSDSE-------------------------SEGPQKGPASDSETEDASR--HKQKPESD 330
R + E S P + P E D + ++K E
Sbjct: 189 RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEER 248
Query: 331 DDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVA 390
D D+E + S S S + EEEE +++ S+E E+E EEE+
Sbjct: 249 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEE 308
Query: 391 KRKAAVLSDSEDEEKASAKKSRVVSDADDSDSD----AVSDKSGKREKTIASDSEEEAGK 446
+ + S+ E+ A +S+ ++ +++ V + R+ + ++EEE G+
Sbjct: 309 EEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGE 368
Score = 57.4 bits (137), Expect = 5e-08
Identities = 75/374 (20%), Positives = 137/374 (36%), Gaps = 46/374 (12%)
Query: 85 EELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS-ESEETRK------LPGSDSENEE 137
+E+ ++K E EE+AE +N D DS E E R + S E+
Sbjct: 14 DEILQEKKRRKEQEEKAE--IKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRRED 71
Query: 138 LLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASD 197
+ E++ + P +E + E ++ + E E RH+
Sbjct: 72 SMEDRGE--EDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQ 129
Query: 198 S----ENEEPPKPRMSDSES-------EELPKPQVSDSESEEPPRHQASDSENEELPKPR 246
E E + M+ S E+L + + + + E + Q E E + R
Sbjct: 130 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 189
Query: 247 ISDSES--EDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSES 304
+ E+ E H+ + + K PPR + + + K +
Sbjct: 190 RKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD 249
Query: 305 EGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSD 364
SDSE + +S ES S+ E + E+ E + S
Sbjct: 250 LLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEE---------------GST 294
Query: 365 SEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSD---SEDEEKASAKKSRVVS----DA 417
SEE E ++++ + +E+E E+ +++ A +S+ SEDEE+ + VV D
Sbjct: 295 SEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDR 354
Query: 418 DDSDSDAVSDKSGK 431
D +S+ ++ G+
Sbjct: 355 DSGESEEAEEEVGE 368
Score = 52.4 bits (124), Expect = 2e-06
Identities = 66/380 (17%), Positives = 134/380 (35%), Gaps = 39/380 (10%)
Query: 49 SENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERA-EPPASD 107
+ ++ + D L +G D + + +S +D E + A +PP
Sbjct: 37 NSDDRDSKRDSLEEGEL-----RDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQM 91
Query: 108 SENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKS 167
S E V+ + E+ + + E+E E +D + + E+ +
Sbjct: 92 SRKEKVHHRKDEKRKEKWKHARVKEREHER----RKRHREEQDKARREWERQKRREMARE 147
Query: 168 PASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESE 227
+ D L+ E E R Q + ++ + R + E + +VS
Sbjct: 148 HSR--RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS----- 200
Query: 228 EPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQAS 287
H+ + + K PPR E EL R E + R+ S
Sbjct: 201 --AHHRTMREDYSDKVKASHWSRSPPRPPR------ERFELGDGRKPVKEEKMEERDLLS 252
Query: 288 DSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQND 347
D ++ + + S +ES + G S+ E E+ +++ + ++S+ E + E+ E +
Sbjct: 253 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 312
Query: 348 SFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKAS 407
S+SEE + + S+E+ E EE + V D +
Sbjct: 313 G--------------SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 358
Query: 408 AKKSRVVSDADDSDSDAVSD 427
++++ S A+++
Sbjct: 359 SEEAEEEVGEGTPQSSALTE 378
Score = 43.9 bits (102), Expect = 6e-04
Identities = 44/183 (24%), Positives = 70/183 (38%), Gaps = 20/183 (10%)
Query: 41 DTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEER 100
+ G + + E + D L ++DSE S +ES S+ E EE
Sbjct: 232 ELGDGRKPVKEEKMEERDLLSDLQDISDSER------KTSSAESSSAESGSGSEEEEEEE 285
Query: 101 AEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSE 160
E S +E+ + + E EE + GS+SE AS+ E+V + S+ E
Sbjct: 286 EEEEEEGSTSEESEE--EEEEEEEEEEETGSNSE-------EASEQSAEEVSEEEMSEDE 336
Query: 161 IEE----LQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSE-SEE 215
E L P S + + + + E P+ A + P P + E +E
Sbjct: 337 ERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQE 396
Query: 216 LPK 218
LPK
Sbjct: 397 LPK 399
Score = 37.4 bits (85), Expect = 0.057
Identities = 41/156 (26%), Positives = 60/156 (38%), Gaps = 18/156 (11%)
Query: 15 GATPVQDE----RDSGSDGEDDVNEQH-------SGSDTGSVERHSENETSDREDGLPKG 63
G PV++E RD SD +D + + S +++GS E E + E+
Sbjct: 236 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 295
Query: 64 HHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESE 123
+ E +E + S SEE Q + EE +E D E E+ N ES
Sbjct: 296 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE----DEERENENHLLVVPESR 351
Query: 124 ETRKLPGSDSENEELLNGHASDS---ENEDVGKHPA 156
R S+ EE+ G S E + V PA
Sbjct: 352 FDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPA 387
Score = 32.7 bits (73), Expect = 1.4
Identities = 35/159 (22%), Positives = 63/159 (39%), Gaps = 34/159 (21%)
Query: 24 DSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSE 83
+SGS E++ E+ + GS +E S+ E E
Sbjct: 273 ESGSGSEEEEEEEEEEEEEGST-----SEESEEE-------------------------E 302
Query: 84 SEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHA 143
EE ++++ S SEE +E A + E++++ D E E L + +G +
Sbjct: 303 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSE---DEERENENHLLVVPESRFDRDSGES 359
Query: 144 SDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQI 182
++E E+VG+ S + E P S + LK ++
Sbjct: 360 EEAE-EEVGEGTPQSSALTEGDYVPDSPALLPIELKQEL 397
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 77.4 bits (189), Expect = 5e-14
Identities = 84/372 (22%), Positives = 152/372 (40%), Gaps = 55/372 (14%)
Query: 153 KHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSE 212
K +EI+ L+ S DS+ + + ++ D E R+ S E+ + R + +
Sbjct: 24 KEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRN--SPYRREDSMEDRGEEDD 81
Query: 213 SEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPR 272
S + PQ S + H D + +E + R +E R + + E+E + R
Sbjct: 82 SLAIKPPQ---QMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHR 138
Query: 273 ISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDD 332
E +D R + + E+ + S E + + +Q+ E +
Sbjct: 139 ----EEQDKARREWERQKRREMAREH---SRRERDRLEQLERKRERERKMREQQKEQREQ 191
Query: 333 SDRENKGEDTEMQNDSFHSDS-HMDRKKFHSSDSEEEEH--------KKQKMDSDEDEKE 383
+RE + E+ + ++ S H + SD + H +++ + + K
Sbjct: 192 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKP 251
Query: 384 GEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEE 443
+EEK+ +R +LSD +D +SD++ S A S S +E
Sbjct: 252 VKEEKMEERD--LLSDLQD-----------ISDSERKTSSAES-----------SSAESG 287
Query: 444 AGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGET 503
+G E +++ EE++ GS SE EE E +EEEEE TG N E+ E+ E
Sbjct: 288 SGSEEEEEEEEEEEEEGSTSEESEEE---------EEEEEEEEEETGSNSEEASEQSAE- 337
Query: 504 QVKEAEDSDSDD 515
+V E E S+ ++
Sbjct: 338 EVSEEEMSEDEE 349
Score = 62.8 bits (151), Expect = 1e-09
Identities = 72/366 (19%), Positives = 139/366 (37%), Gaps = 43/366 (11%)
Query: 121 ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIE-ELQKSP--ASDS----- 172
+ ++ RK +E + L N DS+ + + + D +E ++ SP DS
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRG 77
Query: 173 ETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRH 232
E +D+L + S + H D + +E + R +E + + + + E E RH
Sbjct: 78 EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRH 137
Query: 233 -QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSEN 291
+ D E + + + E R + E+L + R + + + + Q E
Sbjct: 138 REEQDKARREWERQKRREMAREHSRRER---DRLEQLERKRERERKMREQQKEQREQKER 194
Query: 292 EELPKPRVSDSE-------------------------SEGPQKGPASDSETEDASR--HK 324
E + R + E S P + P E D + +
Sbjct: 195 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 254
Query: 325 QKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEG 384
+K E D D+E + S S S + EEEE +++ S+E E+E
Sbjct: 255 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEE 314
Query: 385 EEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSD----AVSDKSGKREKTIASDS 440
EEE+ + + S+ E+ A +S+ ++ +++ V + R+ + ++
Sbjct: 315 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEA 374
Query: 441 EEEAGK 446
EEE G+
Sbjct: 375 EEEVGE 380
Score = 57.8 bits (138), Expect = 4e-08
Identities = 72/370 (19%), Positives = 137/370 (37%), Gaps = 38/370 (10%)
Query: 83 ESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEEL-LNG 141
E E+ R K+SD +R + + + +S + E++ L +
Sbjct: 28 EKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKP 87
Query: 142 HASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDS--- 198
S E V H D + +E ++ + +E + + + E E RH+
Sbjct: 88 PQQMSRKEKV--HHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKAR 145
Query: 199 -ENEEPPKPRMSDSES-------EELPKPQVSDSESEEPPRHQASDSENEELPKPRISDS 250
E E + M+ S E+L + + + + E + Q E E + R +
Sbjct: 146 REWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKER 205
Query: 251 ES--EDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQ 308
E+ E H+ + + K PPR + + + K +
Sbjct: 206 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSD 265
Query: 309 KGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEE 368
SDSE + +S ES S+ E + E+ E + S SEE
Sbjct: 266 LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEE---------------GSTSEES 310
Query: 369 EHKKQKMDSDEDEKEGEEEKVAKRKAAVLSD---SEDEEKASAKKSRVVS----DADDSD 421
E ++++ + +E+E E+ +++ A +S+ SEDEE+ + VV D D +
Sbjct: 311 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 370
Query: 422 SDAVSDKSGK 431
S+ ++ G+
Sbjct: 371 SEEAEEEVGE 380
Score = 56.2 bits (134), Expect = 1e-07
Identities = 79/405 (19%), Positives = 148/405 (36%), Gaps = 53/405 (13%)
Query: 49 SENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERA-EPPASD 107
+ ++ + D L +G D + + +S +D E + A +PP
Sbjct: 37 NSDDRDSKRDSLEEGEL-----RDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQM 91
Query: 108 SENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKH-PASDSEIEELQK 166
S E V+ H D + +E R+ +E + + E+E +H D E ++
Sbjct: 92 SRKEKVH-HRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWER 150
Query: 167 SPASDSETE------DALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQ 220
+ E D L+ E E R Q + ++ + R + E + +
Sbjct: 151 QKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARRE 210
Query: 221 VSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESED 280
VS H+ + + K PPR E EL R E +
Sbjct: 211 VS-------AHHRTMREDYSDKVKASHWSRSPPRPPR------ERFELGDGRKPVKEEKM 257
Query: 281 PPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGE 340
R+ SD ++ + + S +ES + G S+ E E+ +++ + ++S+ E + E
Sbjct: 258 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 317
Query: 341 DTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEE-----------EKV 389
+ E + S+SEE + + S+E+ E EE E
Sbjct: 318 EEEEEETG--------------SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESR 363
Query: 390 AKRKAAVLSDSEDEEKASAKKSRVVSDAD-DSDSDAVSDKSGKRE 433
R + ++E+E +S +++ D DS A+S K+E
Sbjct: 364 FDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQE 408
Score = 46.2 bits (108), Expect = 1e-04
Identities = 45/183 (24%), Positives = 71/183 (38%), Gaps = 20/183 (10%)
Query: 41 DTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEER 100
+ G + + E + D L ++DSE S +ES S+ E EE
Sbjct: 244 ELGDGRKPVKEEKMEERDLLSDLQDISDSER------KTSSAESSSAESGSGSEEEEEEE 297
Query: 101 AEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSE 160
E S +E+ + + E EE + GS+SE AS+ E+V + S+ E
Sbjct: 298 EEEEEEGSTSEESEE--EEEEEEEEEEETGSNSE-------EASEQSAEEVSEEEMSEDE 348
Query: 161 IEE----LQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSE-SEE 215
E L P S + + + + E P+ A + P P +S E +E
Sbjct: 349 ERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQE 408
Query: 216 LPK 218
LPK
Sbjct: 409 LPK 411
Score = 38.9 bits (89), Expect = 0.020
Identities = 46/168 (27%), Positives = 66/168 (39%), Gaps = 19/168 (11%)
Query: 15 GATPVQDE----RDSGSDGEDDVNEQH-------SGSDTGSVERHSENETSDREDGLPKG 63
G PV++E RD SD +D + + S +++GS E E + E+
Sbjct: 248 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 307
Query: 64 HHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESE 123
+ E +E + S SEE Q + EE +E D E E+ N ES
Sbjct: 308 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE----DEERENENHLLVVPESR 363
Query: 124 ETRKLPGSDSENEELLNGHASDS---ENEDVGKHPASDSEIEELQKSP 168
R S+ EE+ G S E + V PA S IE Q+ P
Sbjct: 364 FDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL-SPIELKQELP 410
Score = 33.5 bits (75), Expect = 0.82
Identities = 35/159 (22%), Positives = 64/159 (40%), Gaps = 34/159 (21%)
Query: 24 DSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSE 83
+SGS E++ E+ + GS +E S+ E E
Sbjct: 285 ESGSGSEEEEEEEEEEEEEGST-----SEESEEE-------------------------E 314
Query: 84 SEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHA 143
EE ++++ S SEE +E A + E++++ D E E L + +G +
Sbjct: 315 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSE---DEERENENHLLVVPESRFDRDSGES 371
Query: 144 SDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQI 182
++E E+VG+ S + E P S + + LK ++
Sbjct: 372 EEAE-EEVGEGTPQSSALTEGDYVPDSPALSPIELKQEL 409
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 76.6 bits (187), Expect = 8e-14
Identities = 101/512 (19%), Positives = 192/512 (37%), Gaps = 76/512 (14%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLP 61
DSE S + E SGSD +DD N+ + G ++ ++ ED
Sbjct: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAK-GKAQKSNKKWDGSEED--- 167
Query: 62 KGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENED--------- 112
+ + E + S ES+E + + ++++ P +S NED
Sbjct: 168 EDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKT 227
Query: 113 VNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEE-LQKS---- 167
V Q ++ + E +K ++ +L ++ +D K S + EE KS
Sbjct: 228 VAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTV 287
Query: 168 -----PASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVS 222
PAS+ + E + + ++ + E EE K + + Q +
Sbjct: 288 DTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEA 347
Query: 223 DSESEEPPRHQASDSEN-----EELPKPRISDSESEDPPRHQASDSENEELPKPR----- 272
++ +E Q + E EEL R + E R + E E + +
Sbjct: 348 LAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKL 407
Query: 273 ISDSESEDPPRNQAS-------------------------DSENEELPKPRVSDSESEGP 307
++ S+ E R +A+ D + +++P+ S SE
Sbjct: 408 LTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESM 467
Query: 308 QKGPASDSETEDASRHKQKP---ESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSD 364
+ A + + ++ P E +++ D E+ G D S ++ K H
Sbjct: 468 ELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV 527
Query: 365 SEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDA 424
E E ++++ + +E+++E EEE+ + ++ E++EK S D+ DS
Sbjct: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVS----------DEKDSGK 577
Query: 425 VSDKSGKREKTIASDSEEEAGKELSDKKNEEK 456
DK K K ++SDSE ++ D+ EE+
Sbjct: 578 TLDK--KPSKEMSSDSEYDSD---DDRTKEER 604
Score = 66.6 bits (161), Expect = 9e-11
Identities = 100/540 (18%), Positives = 200/540 (37%), Gaps = 37/540 (6%)
Query: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLP 61
+ E+ S D+ G Q D+ S+ +D + + + VE +S ++ D + LP
Sbjct: 88 EEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLP 147
Query: 62 KGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSE 121
K ++++ + + D ++ + +++ + S E + D +E + +
Sbjct: 148 KKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGE-----SGDESDEFLQSRKGQKK 202
Query: 122 SEETRKLPGSDSENEE-----LLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETED 176
+++ + P +S NE+ + A + + D E +L+K + E E
Sbjct: 203 NQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKE-ELET 261
Query: 177 ALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASD 236
K Q ES+ + S+ + E E P D+E ++ + +
Sbjct: 262 GKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKK 321
Query: 237 S-ENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELP 295
E EE K E + P + E L K + + E + EEL
Sbjct: 322 KGEKEEKEK------EKKKGPSKATVKAMQEALAK--LKEEEERQKREEEERIKRLEELE 373
Query: 296 KPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDT------EMQNDSF 349
R + E ++ E E R K++ + S RE + + Q
Sbjct: 374 AKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEV 433
Query: 350 HSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAK 409
S + +K+ E+ K++K+ + KE E V+ E++ +
Sbjct: 434 PSKDSLPKKR-----PIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPP 488
Query: 410 KSRVVSDADDSDS---DAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESG 466
+ D D+ D + S + + + + KE +++ EE++ D ES
Sbjct: 489 PVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESE 548
Query: 467 NEEENLIADIFGESGDEEEEEFTGFNQ--EDLEEEKGETQVKEAEDSDSDDNIKRGKHMD 524
EEE + G GDEE+E+ + + L+++ + ++E DD K + D
Sbjct: 549 EEEEEE-GESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYD 607
Score = 65.9 bits (159), Expect = 1e-10
Identities = 102/509 (20%), Positives = 201/509 (39%), Gaps = 58/509 (11%)
Query: 81 DSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLN 140
D++SEEL +D DS+S++ A+P V + + ++ KLP + N
Sbjct: 110 DNDSEEL---EDKDSKSKKTAKPK--------VEMYSGSDDDDDFNKLPKKAKGKAQKSN 158
Query: 141 GHASDSE-NEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSE 199
SE +ED K S I +S E + K Q + +++ P ++ + +
Sbjct: 159 KKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNED 218
Query: 200 NEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQ 259
++ K + + E + + + E+ + E EEL + S+ ++ R
Sbjct: 219 DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLK--EKEELETGKKDQSKQKESQR-- 274
Query: 260 ASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDS-ETE 318
EE K +++ P + E E P D+E + +K E E
Sbjct: 275 ---KFEEETVKSKVTVDTGVIP-----ASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKE 326
Query: 319 DASRHKQKPESD------DDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKK 372
+ + K+K S ++ + K E+ + + + + R + + +EEE +
Sbjct: 327 EKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREE---EERIKRLEELEAKRKEEERLE 383
Query: 373 QKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDA-------- 424
Q+ + +KE E ++ K++ +L+ S+ E +A A+ + + A + +
Sbjct: 384 QEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR 443
Query: 425 --VSDKSGKR------EKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIA-- 474
DK K+ K ++ E A E+ ++ EK+ E EE+ A
Sbjct: 444 PIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL 503
Query: 475 -DIFGESGDEEEEEFTGFN-----QEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSD 528
D + DEE E+ G +E+ EEE+ E + +E ++ ++ + G+ D
Sbjct: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGD 563
Query: 529 FEMMLQRKKSMSGKRRRNRDGGTFISDAD 557
E + SGK + SD++
Sbjct: 564 EEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592
Score = 62.4 bits (150), Expect = 2e-09
Identities = 104/526 (19%), Positives = 207/526 (39%), Gaps = 63/526 (11%)
Query: 46 ERHSENETS-DREDGLPKGHHVTDSENDEPLNLNASDSESE-------ELHRQKDSDSES 97
E + E TS D++ KG + +ND L DS+S+ E++ D D +
Sbjct: 85 ENNEEEFTSKDKKKKGQKGKKQSFDDNDSE-ELEDKDSKSKKTAKPKVEMYSGSDDDDDF 143
Query: 98 EERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPAS 157
+ + ++ + GS+ + + ++K+ E + + S E+++ +
Sbjct: 144 NKLPKKAKGKAQKSNKKWDGSEEDEDNSKKI----KERSRINSSGESGDESDEFLQSRKG 199
Query: 158 DSEIEELQKSP--ASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEE 215
+ ++ + P S +E +DA + ++ + + + +EE K R E EE
Sbjct: 200 QKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL-KEKEE 258
Query: 216 LPKPQVSDSESEEPPRHQASDSENEELPKPR----ISDSESEDPPRHQASDSENEELPKP 271
L + S+ +E R ++ ++ S+ ++E P A++ +NE
Sbjct: 259 LETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPT---AAEDDNE----- 310
Query: 272 RISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDD 331
D + +D + + E E+ K S + + Q+ A E E+ +QK E ++
Sbjct: 311 --GDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE----RQKREEEE 364
Query: 332 DSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKM-DSDEDEKEGEEEKVA 390
R + E + + + +RKK + +E K+ K+ + E E
Sbjct: 365 RIKRLEELEAKRKEEERLEQEKR-ERKKQKEKERKERLKKEGKLLTKSQREARARAEATL 423
Query: 391 K----------------RKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREK 434
K +K + D + ++ +S+ VS++ + + + G EK
Sbjct: 424 KLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEK 483
Query: 435 TIASDS-EEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEE------EEE 487
E E ++ D ++ + SD E+ E N + E+ +EE EEE
Sbjct: 484 EETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEE 543
Query: 488 FTGFNQEDLEEEKGETQVKEAEDSDS--DDNIKRGKHMDFLSDFEM 531
E+ EEE+GE++ E ++ D D GK +D EM
Sbjct: 544 --DEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEM 587
Score = 55.5 bits (132), Expect = 2e-07
Identities = 79/438 (18%), Positives = 161/438 (36%), Gaps = 42/438 (9%)
Query: 126 RKLPGSDSENEEL-LNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISD 184
+K DS +++ L+ A++ E K + +K ED + ++ +
Sbjct: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
Query: 185 SESE------EPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSE 238
E + +EN E + + K Q D E + DS+
Sbjct: 65 LSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSE--ELEDKDSK 122
Query: 239 NEELPKPRISDSESEDPPRHQASDSENEELPKP---RISDSESEDPPRNQASDSENEELP 295
+++ KP++ D D + +LPK + S + + D+ +
Sbjct: 123 SKKTAKPKVEMYSGSD------DDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKE 176
Query: 296 KPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHM 355
+ R++ S G + S K KP + +S E+ D+
Sbjct: 177 RSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNED-------------DDASF 223
Query: 356 DRKKFHSSDSEEEEHKKQKMDSDEDE----KEGEEEKVAKRKAAVLSDSEDEEKASAKKS 411
K +E++E +++K D ++ + KE EE + K+ + +S+ + + KS
Sbjct: 224 KIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKS 283
Query: 412 RVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNE--EKDLFGSDSESGNEE 469
+V D+ + K E A++ + E K+ DKK + EK+ + + G +
Sbjct: 284 KVT-----VDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSK 338
Query: 470 ENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDF 529
+ A + +EEEE +E+ + E + K E+ + + K
Sbjct: 339 ATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERK 398
Query: 530 EMMLQRKKSMSGKRRRNR 547
E + + K ++ +R R
Sbjct: 399 ERLKKEGKLLTKSQREAR 416
Score = 47.4 bits (111), Expect = 5e-05
Identities = 60/268 (22%), Positives = 110/268 (41%), Gaps = 21/268 (7%)
Query: 324 KQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKE 383
KQK +S+D + + + + + + + +K S +++E KKQ D D+ KE
Sbjct: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQK--SKGKKKKEKKKQDFDEDDILKE 61
Query: 384 GEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEE 443
EE LS KA + V ++ + DK K +K ++
Sbjct: 62 LEE----------LSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDN 111
Query: 444 AGKELSDKKNEEKDLFGSDSE--SGNEEENLIADIFGESGDEEEEEFTGFNQE-DLEEEK 500
+EL DK ++ K E SG++++ D F + + + + N++ D EE
Sbjct: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDD----DDFNKLPKKAKGKAQKSNKKWDGSEED 167
Query: 501 GETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVV 560
+ K E S + + + G D + +KK+ K N + G DA +
Sbjct: 168 EDNSKKIKERSRINSSGESGDESD--EFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKI 225
Query: 561 SAMIVKMNEAAEEDRQLNNQKKPALKKL 588
+ K E E +R+ +++K L+KL
Sbjct: 226 KTVAQKKAEKKERERKKRDEEKAKLRKL 253
Score = 32.3 bits (72), Expect = 1.8
Identities = 23/98 (23%), Positives = 40/98 (40%), Gaps = 1/98 (1%)
Query: 30 EDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSEND-EPLNLNASDSESEELH 88
E++ E+ D S E E S+ +G + V+D ++ + L+ S S +
Sbjct: 533 EEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592
Query: 89 RQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETR 126
D D EERA A + +H + +E+ R
Sbjct: 593 YDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630
Score = 30.8 bits (68), Expect = 5.3
Identities = 27/141 (19%), Positives = 52/141 (36%), Gaps = 8/141 (5%)
Query: 45 VERHSENETSDREDGLPKGHHVTDSENDEPLNLNA------SDSESEELHRQKDSDSESE 98
VE E +T D GL + E E + N + E EE +++ + E
Sbjct: 490 VEPEEEEDTEDA--GLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEES 547
Query: 99 ERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASD 158
E E +SE + ++ E+ ++E+ + DS+++ + A D
Sbjct: 548 EEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYD 607
Query: 159 SEIEELQKSPASDSETEDALK 179
++K S+ + K
Sbjct: 608 KAKRRIEKRRLEHSKNVNTEK 628
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.300 0.121 0.324
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,667,324
Number of Sequences: 37866
Number of extensions: 2187557
Number of successful extensions: 45028
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 592
Number of HSP's successfully gapped in prelim test: 1861
Number of HSP's that attempted gapping in prelim test: 11067
Number of HSP's gapped (non-prelim): 14518
length of query: 819
length of database: 18,247,518
effective HSP length: 111
effective length of query: 708
effective length of database: 14,044,392
effective search space: 9943429536
effective search space used: 9943429536
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.