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Search of human proteins with 217330557
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217330557 unc-51-like kinase 2 [Homo sapiens]
(1036 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 2087 0.0
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 2087 0.0
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 946 0.0
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 191 3e-48
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 166 1e-40
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 160 4e-39
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 160 6e-39
gi|23943882 serine/threonine kinase 33 [Homo sapiens] 160 6e-39
gi|121114283 polo-like kinase 4 [Homo sapiens] 158 2e-38
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 154 4e-37
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 154 4e-37
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 154 4e-37
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 154 4e-37
gi|115529463 protein kinase D1 [Homo sapiens] 153 9e-37
gi|5031689 protein kinase D3 [Homo sapiens] 152 1e-36
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 152 1e-36
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 152 2e-36
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 152 2e-36
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 152 2e-36
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 152 2e-36
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 152 2e-36
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 152 2e-36
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 151 4e-36
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 149 1e-35
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 149 1e-35
gi|156105707 SNF related kinase [Homo sapiens] 149 2e-35
gi|156105705 SNF related kinase [Homo sapiens] 149 2e-35
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 149 2e-35
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 149 2e-35
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 149 2e-35
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 2087 bits (5408), Expect = 0.0
Identities = 1036/1036 (100%), Positives = 1036/1036 (100%)
Query: 1 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL 60
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
Sbjct: 1 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL 60
Query: 61 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR 120
KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR
Sbjct: 61 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR 120
Query: 121 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY 180
ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
Sbjct: 121 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY 180
Query: 181 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET 240
MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET
Sbjct: 181 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET 240
Query: 241 SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP 300
SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP
Sbjct: 241 SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP 300
Query: 301 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI 360
SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI
Sbjct: 301 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI 360
Query: 361 SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST 420
SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST
Sbjct: 361 SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST 420
Query: 421 ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL 480
ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL
Sbjct: 421 ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL 480
Query: 481 VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ 540
VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ
Sbjct: 481 VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ 540
Query: 541 KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS 600
KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS
Sbjct: 541 KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS 600
Query: 601 PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS 660
PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS
Sbjct: 601 PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS 660
Query: 661 KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS 720
KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS
Sbjct: 661 KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS 720
Query: 721 KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS 780
KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS
Sbjct: 721 KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS 780
Query: 781 PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV 840
PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV
Sbjct: 781 PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV 840
Query: 841 LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH 900
LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH
Sbjct: 841 LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH 900
Query: 901 LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT 960
LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT
Sbjct: 901 LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT 960
Query: 961 AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC 1020
AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC
Sbjct: 961 AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC 1020
Query: 1021 SIERRLSALCHSTATV 1036
SIERRLSALCHSTATV
Sbjct: 1021 SIERRLSALCHSTATV 1036
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 2087 bits (5408), Expect = 0.0
Identities = 1036/1036 (100%), Positives = 1036/1036 (100%)
Query: 1 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL 60
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
Sbjct: 1 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL 60
Query: 61 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR 120
KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR
Sbjct: 61 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR 120
Query: 121 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY 180
ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
Sbjct: 121 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY 180
Query: 181 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET 240
MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET
Sbjct: 181 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET 240
Query: 241 SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP 300
SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP
Sbjct: 241 SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP 300
Query: 301 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI 360
SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI
Sbjct: 301 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI 360
Query: 361 SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST 420
SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST
Sbjct: 361 SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST 420
Query: 421 ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL 480
ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL
Sbjct: 421 ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL 480
Query: 481 VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ 540
VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ
Sbjct: 481 VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ 540
Query: 541 KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS 600
KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS
Sbjct: 541 KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS 600
Query: 601 PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS 660
PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS
Sbjct: 601 PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS 660
Query: 661 KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS 720
KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS
Sbjct: 661 KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS 720
Query: 721 KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS 780
KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS
Sbjct: 721 KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS 780
Query: 781 PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV 840
PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV
Sbjct: 781 PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV 840
Query: 841 LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH 900
LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH
Sbjct: 841 LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH 900
Query: 901 LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT 960
LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT
Sbjct: 901 LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT 960
Query: 961 AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC 1020
AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC
Sbjct: 961 AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC 1020
Query: 1021 SIERRLSALCHSTATV 1036
SIERRLSALCHSTATV
Sbjct: 1021 SIERRLSALCHSTATV 1036
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 946 bits (2446), Expect = 0.0
Identities = 565/1079 (52%), Positives = 686/1079 (63%), Gaps = 94/1079 (8%)
Query: 2 EVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILK 61
E VG FE+S++DL+GHGAFAVVF+GRHR+K D EVA+K INKKNL+KSQ LLGKEIKILK
Sbjct: 9 ETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILK 68
Query: 62 ELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRI 121
EL+HENIVALYD QE+ NSV+LVMEYCNGGDLADYL A TLSEDTIR+FL QIA AMR+
Sbjct: 69 ELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRL 128
Query: 122 LHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYM 181
LHSKGIIHRDLKPQNILLS R+++ + IR+KIADFGFARYL SNMMAATLCGSPMYM
Sbjct: 129 LHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYM 188
Query: 182 APEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
APEVIMSQHYD KADLWSIGT++YQCL GK PFQA+SPQDLR+FYEKN++L+P+IPRETS
Sbjct: 189 APEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETS 248
Query: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGP-VKKSCPVPVPMYSGSVSGSSCGSSP 300
L LLL LLQRN KDRMDF+ FF HPFL+ P V+KS PVPVP Y S SGSS SS
Sbjct: 249 APLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSS 308
Query: 301 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI 360
+ ASPPSL +MQ +Q+ S P +L S+DS SK+SSCDTDDFV+VP
Sbjct: 309 TSHLASPPSLGEMQQLQKTLAS--PADTAGFLHSSRDSG--GSKDSSCDTDDFVMVPAQF 364
Query: 361 SSDHSCDMP----------------VGTAGRRASNEFLVCGGQCQPTVSPHSE------- 397
D + P V +AG + C + SP
Sbjct: 365 PGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSS 424
Query: 398 ----TAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRS-NTSPMGFLRPGSC 452
+ PIPVPTQ++NYQRIE+NL S T PRS+ +RRS +TSP+GF R
Sbjct: 425 RCGASVPIPVPTQVQNYQRIERNLQSPTQFQT-----PRSSAIRRSGSTSPLGFARASPS 479
Query: 453 SPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNS--SGSP 510
P A+ + R++S G RPY+PSP VGTIPE+ PQG + R S GS
Sbjct: 480 PPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSS 539
Query: 511 VPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRP-G 569
P+ SP++ G RL SAP L+D++ + KL K +DP+ GA +S PQ S P
Sbjct: 540 APE-HSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPL-----GAVFS-PPQASPPQP 592
Query: 570 SLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHG-- 627
S G ++L SP+ D+ + PLP I+GSPTK F PKT +S NLLAL+ R G
Sbjct: 593 SHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVV 652
Query: 628 ---PAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPI-- 682
P D +E L G R + K FGRS ST +L+D K
Sbjct: 653 MTPPRNRTLPDLSEVGPFHGQPLGPG---LRPGEDPKGPFGRSFSTSRLTDLLLKAAFGT 709
Query: 683 -CRHQGSTDSLNTERPMDIAPAGACGGVLAP--PAGTAASSKAVLFTVGSPPHSAAAPTC 739
GST+SL E+PM+IAP+ GG L P AG +S V+FTVGSPP + P
Sbjct: 710 QAPDPGSTESLQ-EKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQG 768
Query: 740 THMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSP---------PGPGFGSSPPGAEAAPSL 790
RTR S GP+ S S S R V P P PG G S AA
Sbjct: 769 P----RTRMFSAGPTGSASS----SARHLVPGPCSEAPAPELPAPGHGCSFADPIAA--- 817
Query: 791 RYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGN 850
+LEG +TFEAP+LPEETLME+EHT+ LR L L+F + VL++ A++G
Sbjct: 818 ----------NLEGAVTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSA 867
Query: 851 PELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGK 910
E + YQ+QESVV DQIS LS++WG EQLVLY+K A+LL++ L A QI++GK
Sbjct: 868 SE--AAGGPEYQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQSAIDQIRAGK 925
Query: 911 LSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAV 970
L S+ VKQVV+ LNE YK + C+ L+ +L RFF DKQR +D I+S+TAE+LI++ AV
Sbjct: 926 LCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDRIHSITAERLIFSHAV 985
Query: 971 EMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSAL 1029
+MVQSAALDEMFQ E V RYHKA LLLEGL +L D ADIENV K K IERRLSAL
Sbjct: 986 QMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHMLSDQADIENVTKCKLCIERRLSAL 1044
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 191 bits (485), Expect = 3e-48
Identities = 102/259 (39%), Positives = 162/259 (62%), Gaps = 8/259 (3%)
Query: 15 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKELQHENIVALYD 73
+G G +A V++ ++ T VAIK + KK+L+K+ + L EI+ILK ++H +IV L D
Sbjct: 20 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKD 79
Query: 74 VQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLK 133
Q ++++L+ME+C GGDL+ ++ + L E RVF+ Q+A+A++ LH + I H DLK
Sbjct: 80 FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLK 139
Query: 134 PQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDA 193
PQNILLS S+ +K+ADFGFA+++ L GSP+YMAPE++ + YDA
Sbjct: 140 PQNILLS-------SLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDA 192
Query: 194 KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQ 253
+ DLWS+G ++Y+ L G+PPF + S +L NR + + S +LL LL+
Sbjct: 193 RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLE 252
Query: 254 RNQKDRMDFEAFFSHPFLE 272
R+ R+ F+ FF+HP+++
Sbjct: 253 RDPSRRISFQDFFAHPWVD 271
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 166 bits (420), Expect = 1e-40
Identities = 99/266 (37%), Positives = 150/266 (56%), Gaps = 16/266 (6%)
Query: 8 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKELQHE 66
+Y +++G G+F V++GR + VA+K I K S+ ++ L +EI+I++ L+H
Sbjct: 3 KYHVLEMIGEGSFGRVYKGRRKYSAQ-VVALKFIPKLGRSEKELRNLQREIEIMRGLRHP 61
Query: 67 NIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKG 126
NIV + D E V +V +Y G +L L+ G L ED ++ Q+ +A+ LHS
Sbjct: 62 NIVHMLDSFETDKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHR 120
Query: 127 IIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAAT-LCGSPMYMAPEV 185
I+HRD+KPQNILL+ G IK+ DFGFAR + +N M T + G+P+YM+PE+
Sbjct: 121 ILHRDMKPQNILLA---------KGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPEL 171
Query: 186 IMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLA 245
+ + YD ADLWS+G ++Y+ VG PPF A S L K+ PS SP
Sbjct: 172 VEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPS---TISPCFK 228
Query: 246 NLLLGLLQRNQKDRMDFEAFFSHPFL 271
N L GLL ++ + R+ + HPF+
Sbjct: 229 NFLQGLLTKDPRQRLSWPDLLYHPFI 254
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 160 bits (406), Expect = 4e-39
Identities = 156/538 (28%), Positives = 238/538 (44%), Gaps = 68/538 (12%)
Query: 2 EVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKIL 60
+ VG + K +G G +V G H T +VAIK +N++ LS+S ++ + +EI IL
Sbjct: 14 QYVGPYRLEKT--LGKGQTGLVKLGVHCV-TCQKVAIKIVNREKLSESVLMKVEREIAIL 70
Query: 61 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR 120
K ++H +++ L+DV E ++LV+E+ +GG+L DYL KG L+ R F QI +A+
Sbjct: 71 KLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALD 130
Query: 121 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY 180
HS I HRDLKP+N+LL N I+IADFG A + + T CGSP Y
Sbjct: 131 FCHSHSICHRDLKPENLLLDEKN---------NIRIADFGMASLQVGDSLLETSCGSPHY 181
Query: 181 MAPEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRE 239
PEVI + YD KAD+WS G +++ LVG PF +LR EK + + +P
Sbjct: 182 ACPEVIRGEKYDGRKADVWSCGVILFALLVGALPF---DDDNLRQLLEKVKRGVFHMPHF 238
Query: 240 TSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSS 299
P +LL G+++ + R+ E H + G + P+P
Sbjct: 239 IPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIP-------------- 284
Query: 300 PSCRFASPPSLPDMQHIQEENLSS-PPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLV-- 356
R SLP ++ I + L S LG + +K S+ + + + L+
Sbjct: 285 ---RKVQIRSLPSLEDIDPDVLDSMHSLG--CFRDRNKLLQDLLSEEENQEKMIYFLLLD 339
Query: 357 -PHNISSDHSCDMP----VGTAGRRASNEFLVCGGQCQP------TVSPHSETAPIPVPT 405
S D+P + +R + L G+ +P +S +P+P
Sbjct: 340 RKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARR 399
Query: 406 QIRNYQRIEQNLT-STASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVG 464
I Q +++ + S ASSG + SP S+ + SP GS P P T
Sbjct: 400 AIEMAQHGQRSRSISGASSGLST--SPLSSPRVTPHPSPR-----GSPLPTPKGTPVHTP 452
Query: 465 RRLSTGSSRPYSP-SPLVGTIP-----EQFSQCCCGHPQGHDSRSRNSSGSPVPQAQS 516
+ G+ P P SP VG +P G P+ H R P P+ S
Sbjct: 453 KESPAGTPNPTPPSSPSVGGVPWRARLNSIKNSFLGSPRFH----RRKLQVPTPEEMS 506
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 160 bits (405), Expect = 6e-39
Identities = 103/287 (35%), Positives = 154/287 (53%), Gaps = 18/287 (6%)
Query: 2 EVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKIL 60
+ VG + K +G G +V G H T +VAIK +N++ LS+S ++ + +EI IL
Sbjct: 29 QYVGPYRLEKT--LGKGQTGLVKLGVHCI-TGQKVAIKIVNREKLSESVLMKVEREIAIL 85
Query: 61 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR 120
K ++H +++ L+DV E ++LV+E+ +GG+L DYL KG L+ R F QI +A+
Sbjct: 86 KLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALD 145
Query: 121 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY 180
HS I HRDLKP+N+LL N I+IADFG A + + T CGSP Y
Sbjct: 146 FCHSYSICHRDLKPENLLLDEKN---------NIRIADFGMASLQVGDSLLETSCGSPHY 196
Query: 181 MAPEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRE 239
PEVI + YD +AD+WS G +++ LVG PF +LR EK + + +P
Sbjct: 197 ACPEVIKGEKYDGRRADMWSCGVILFALLVGALPF---DDDNLRQLLEKVKRGVFHMPHF 253
Query: 240 TSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKS-CPVPVP 285
P +LL G+++ + R+ E HP+ G + C P P
Sbjct: 254 IPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAP 300
>gi|23943882 serine/threonine kinase 33 [Homo sapiens]
Length = 514
Score = 160 bits (405), Expect = 6e-39
Identities = 84/217 (38%), Positives = 131/217 (60%), Gaps = 4/217 (1%)
Query: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQI-LLGKEIKILKELQHEN 67
Y+ ++G G+F +V ++ T+ + AIK +NK+ S + LL +E+ ILK ++HE+
Sbjct: 116 YTFGRILGKGSFGIVIEATDKE-TETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEH 174
Query: 68 IVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGI 127
I+ L V E P ++LVME C G+L + L KG SE+ R + +A+A+ LH+ I
Sbjct: 175 IIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDI 234
Query: 128 IHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFA--RYLHSNMMAATLCGSPMYMAPEV 185
+HRDLK +NI++ + ++ + IK+ DFG A + S M CG+P+YMAPEV
Sbjct: 235 VHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEV 294
Query: 186 IMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDL 222
I + Y + D+WSIG V+Y L G+PPF A+S + L
Sbjct: 295 ISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKL 331
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 158 bits (400), Expect = 2e-38
Identities = 115/358 (32%), Positives = 186/358 (51%), Gaps = 27/358 (7%)
Query: 2 EVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKI 59
E + DF+ +L+G G+FA V+R T EVAIK I+KK + K+ ++ + E+KI
Sbjct: 7 EKIEDFKVG--NLLGKGSFAGVYRAESIH-TGLEVAIKMIDKKAMYKAGMVQRVQNEVKI 63
Query: 60 LKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAK-GTLSEDTIRVFLHQIAAA 118
+L+H +I+ LY+ E N V+LV+E C+ G++ YL+ + SE+ R F+HQI
Sbjct: 64 HCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITG 123
Query: 119 MRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHS-NMMAATLCGS 177
M LHS GI+HRDL N+LL+ + IKIADFG A L + TLCG+
Sbjct: 124 MLYLHSHGILHRDLTLSNLLLT---------RNMNIKIADFGLATQLKMPHEKHYTLCGT 174
Query: 178 PMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMP--S 235
P Y++PE+ + ++D+WS+G + Y L+G+PPF ++ ++ N+ ++
Sbjct: 175 PNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKN-----TLNKVVLADYE 229
Query: 236 IPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSS 295
+P S +L+ LL+RN DR+ + HPF+ + KS + S+
Sbjct: 230 MPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKS--KDLGTVEDSIDSGH 287
Query: 296 CGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDF 353
S + +S S+ + L PL PN + V + S++ +SS D + F
Sbjct: 288 ATISTAITASSSTSISGSLFDKRRLLIGQPL--PNKMTVFPKNKSSTDFSSSGDGNSF 343
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 154 bits (389), Expect = 4e-37
Identities = 95/264 (35%), Positives = 148/264 (56%), Gaps = 12/264 (4%)
Query: 13 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNL-SKSQILLGKEIKILKELQHENIVAL 71
+++G G F VV+ G+HR KT +VA+K I+K +K + L E+ IL+ L+H IV L
Sbjct: 398 EVLGSGQFGVVYGGKHR-KTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNL 456
Query: 72 YDVQELPNSVFLVMEYCNGGDLADYLQA-KGTLSEDTIRVFLHQIAAAMRILHSKGIIHR 130
+ E P VF+VME +G L L + KG L E + + QI A+R LH K I+H
Sbjct: 457 ECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHC 516
Query: 131 DLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQH 190
DLKP+N+LL+ A+ ++K+ DFGFAR + ++ G+P Y+APEV+++Q
Sbjct: 517 DLKPENVLLASADPFP------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQG 570
Query: 191 YDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIP-RETSPYLANLLL 249
Y+ D+WS+G ++Y L G PF N +D+ + + P+ P S +L+
Sbjct: 571 YNRSLDMWSVGVIMYVSLSGTFPF--NEDEDINDQIQNAAFMYPASPWSHISAGAIDLIN 628
Query: 250 GLLQRNQKDRMDFEAFFSHPFLEQ 273
LLQ + R + SHP+L++
Sbjct: 629 NLLQVKMRKRYSVDKSLSHPWLQE 652
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 154 bits (389), Expect = 4e-37
Identities = 95/264 (35%), Positives = 148/264 (56%), Gaps = 12/264 (4%)
Query: 13 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNL-SKSQILLGKEIKILKELQHENIVAL 71
+++G G F VV+ G+HR KT +VA+K I+K +K + L E+ IL+ L+H IV L
Sbjct: 555 EVLGSGQFGVVYGGKHR-KTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNL 613
Query: 72 YDVQELPNSVFLVMEYCNGGDLADYLQA-KGTLSEDTIRVFLHQIAAAMRILHSKGIIHR 130
+ E P VF+VME +G L L + KG L E + + QI A+R LH K I+H
Sbjct: 614 ECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHC 673
Query: 131 DLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQH 190
DLKP+N+LL+ A+ ++K+ DFGFAR + ++ G+P Y+APEV+++Q
Sbjct: 674 DLKPENVLLASADPFP------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQG 727
Query: 191 YDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIP-RETSPYLANLLL 249
Y+ D+WS+G ++Y L G PF N +D+ + + P+ P S +L+
Sbjct: 728 YNRSLDMWSVGVIMYVSLSGTFPF--NEDEDINDQIQNAAFMYPASPWSHISAGAIDLIN 785
Query: 250 GLLQRNQKDRMDFEAFFSHPFLEQ 273
LLQ + R + SHP+L++
Sbjct: 786 NLLQVKMRKRYSVDKSLSHPWLQE 809
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 154 bits (389), Expect = 4e-37
Identities = 95/264 (35%), Positives = 148/264 (56%), Gaps = 12/264 (4%)
Query: 13 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNL-SKSQILLGKEIKILKELQHENIVAL 71
+++G G F VV+ G+HR KT +VA+K I+K +K + L E+ IL+ L+H IV L
Sbjct: 555 EVLGSGQFGVVYGGKHR-KTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNL 613
Query: 72 YDVQELPNSVFLVMEYCNGGDLADYLQA-KGTLSEDTIRVFLHQIAAAMRILHSKGIIHR 130
+ E P VF+VME +G L L + KG L E + + QI A+R LH K I+H
Sbjct: 614 ECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHC 673
Query: 131 DLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQH 190
DLKP+N+LL+ A+ ++K+ DFGFAR + ++ G+P Y+APEV+++Q
Sbjct: 674 DLKPENVLLASADPFP------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQG 727
Query: 191 YDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIP-RETSPYLANLLL 249
Y+ D+WS+G ++Y L G PF N +D+ + + P+ P S +L+
Sbjct: 728 YNRSLDMWSVGVIMYVSLSGTFPF--NEDEDINDQIQNAAFMYPASPWSHISAGAIDLIN 785
Query: 250 GLLQRNQKDRMDFEAFFSHPFLEQ 273
LLQ + R + SHP+L++
Sbjct: 786 NLLQVKMRKRYSVDKSLSHPWLQE 809
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 154 bits (389), Expect = 4e-37
Identities = 95/264 (35%), Positives = 148/264 (56%), Gaps = 12/264 (4%)
Query: 13 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNL-SKSQILLGKEIKILKELQHENIVAL 71
+++G G F VV+ G+HR KT +VA+K I+K +K + L E+ IL+ L+H IV L
Sbjct: 555 EVLGSGQFGVVYGGKHR-KTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNL 613
Query: 72 YDVQELPNSVFLVMEYCNGGDLADYLQA-KGTLSEDTIRVFLHQIAAAMRILHSKGIIHR 130
+ E P VF+VME +G L L + KG L E + + QI A+R LH K I+H
Sbjct: 614 ECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHC 673
Query: 131 DLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQH 190
DLKP+N+LL+ A+ ++K+ DFGFAR + ++ G+P Y+APEV+++Q
Sbjct: 674 DLKPENVLLASADPFP------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQG 727
Query: 191 YDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIP-RETSPYLANLLL 249
Y+ D+WS+G ++Y L G PF N +D+ + + P+ P S +L+
Sbjct: 728 YNRSLDMWSVGVIMYVSLSGTFPF--NEDEDINDQIQNAAFMYPASPWSHISAGAIDLIN 785
Query: 250 GLLQRNQKDRMDFEAFFSHPFLEQ 273
LLQ + R + SHP+L++
Sbjct: 786 NLLQVKMRKRYSVDKSLSHPWLQE 809
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 153 bits (386), Expect = 9e-37
Identities = 95/263 (36%), Positives = 146/263 (55%), Gaps = 12/263 (4%)
Query: 13 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNL-SKSQILLGKEIKILKELQHENIVAL 71
+++G G F +V+ G+HR KT +VAIK I+K +K + L E+ IL+ L H +V L
Sbjct: 587 EVLGSGQFGIVYGGKHR-KTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNL 645
Query: 72 YDVQELPNSVFLVMEYCNGGDLADYLQA-KGTLSEDTIRVFLHQIAAAMRILHSKGIIHR 130
+ E P VF+VME +G L L + KG L E + + QI A+R LH K I+H
Sbjct: 646 ECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHC 705
Query: 131 DLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQH 190
DLKP+N+LL+ A+ ++K+ DFGFAR + ++ G+P Y+APEV+ ++
Sbjct: 706 DLKPENVLLASADPFP------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKG 759
Query: 191 YDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIP-RETSPYLANLLL 249
Y+ D+WS+G +IY L G PF N +D+ + + P P +E S +L+
Sbjct: 760 YNRSLDMWSVGVIIYVSLSGTFPF--NEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLIN 817
Query: 250 GLLQRNQKDRMDFEAFFSHPFLE 272
LLQ + R + SHP+L+
Sbjct: 818 NLLQVKMRKRYSVDKTLSHPWLQ 840
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 152 bits (385), Expect = 1e-36
Identities = 97/263 (36%), Positives = 144/263 (54%), Gaps = 12/263 (4%)
Query: 13 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNL-SKSQILLGKEIKILKELQHENIVAL 71
+++G G F +V+ G+HR KT +VAIK I+K +K + L E+ IL+ L H IV L
Sbjct: 580 EVLGSGQFGIVYGGKHR-KTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNL 638
Query: 72 YDVQELPNSVFLVMEYCNGGDLADYLQA-KGTLSEDTIRVFLHQIAAAMRILHSKGIIHR 130
+ E P VF+VME +G L L + K L E + + QI A+R LH K I+H
Sbjct: 639 ECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHC 698
Query: 131 DLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQH 190
DLKP+N+LL+ A ++K+ DFGFAR + ++ G+P Y+APEV+ S+
Sbjct: 699 DLKPENVLLASAEPFP------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKG 752
Query: 191 YDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIP-RETSPYLANLLL 249
Y+ D+WS+G +IY L G PF N +D+ + + P P RE S +L+
Sbjct: 753 YNRSLDMWSVGVIIYVSLSGTFPF--NEDEDINDQIQNAAFMYPPNPWREISGEAIDLIN 810
Query: 250 GLLQRNQKDRMDFEAFFSHPFLE 272
LLQ + R + SHP+L+
Sbjct: 811 NLLQVKMRKRYSVDKSLSHPWLQ 833
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 152 bits (385), Expect = 1e-36
Identities = 94/245 (38%), Positives = 131/245 (53%), Gaps = 12/245 (4%)
Query: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQI-LLGKEIKILKELQHEN 67
Y +G G FAVV GRHR T EVAIK I+K L + + +E++I+K L H +
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRI-TKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPH 78
Query: 68 IVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGI 127
I+ LY V E + ++LV EY G++ DYL G L+E R QI +A+ H + I
Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138
Query: 128 IHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIM 187
+HRDLK +N+LL + + IKIADFGF + S + AT CGSP Y APEV
Sbjct: 139 VHRDLKAENLLLD---------NNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFE 189
Query: 188 SQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLAN 246
Q Y+ + D+WS+G V+Y + G PF + LR + R +P E +L
Sbjct: 190 GQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIR 249
Query: 247 LLLGL 251
+L L
Sbjct: 250 RMLVL 254
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 152 bits (383), Expect = 2e-36
Identities = 99/273 (36%), Positives = 143/273 (52%), Gaps = 17/273 (6%)
Query: 4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKE 62
+G++ K +G G FA V RH T EVA+K I+K L+ S + L +E++I+K
Sbjct: 50 IGNYRLLKT--IGKGNFAKVKLARHIL-TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKV 106
Query: 63 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 122
L H NIV L++V E +++LVMEY +GG++ DYL A G + E R QI +A++
Sbjct: 107 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 166
Query: 123 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMA 182
H K I+HRDLK +N+LL + + IKIADFGF+ T CGSP Y A
Sbjct: 167 HQKFIVHRDLKAENLLLD---------ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217
Query: 183 PEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
PE+ + YD + D+WS+G ++Y + G PF + ++LR E+ IP S
Sbjct: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR---ERVLRGKYRIPFYMS 274
Query: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 274
NLL L N R E ++ G
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVG 307
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 152 bits (383), Expect = 2e-36
Identities = 99/273 (36%), Positives = 143/273 (52%), Gaps = 17/273 (6%)
Query: 4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKE 62
+G++ K +G G FA V RH T EVA+K I+K L+ S + L +E++I+K
Sbjct: 50 IGNYRLLKT--IGKGNFAKVKLARHIL-TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKV 106
Query: 63 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 122
L H NIV L++V E +++LVMEY +GG++ DYL A G + E R QI +A++
Sbjct: 107 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 166
Query: 123 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMA 182
H K I+HRDLK +N+LL + + IKIADFGF+ T CGSP Y A
Sbjct: 167 HQKFIVHRDLKAENLLLD---------ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217
Query: 183 PEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
PE+ + YD + D+WS+G ++Y + G PF + ++LR E+ IP S
Sbjct: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR---ERVLRGKYRIPFYMS 274
Query: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 274
NLL L N R E ++ G
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVG 307
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 152 bits (383), Expect = 2e-36
Identities = 99/273 (36%), Positives = 143/273 (52%), Gaps = 17/273 (6%)
Query: 4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKE 62
+G++ K +G G FA V RH T EVA+K I+K L+ S + L +E++I+K
Sbjct: 50 IGNYRLLKT--IGKGNFAKVKLARHIL-TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKV 106
Query: 63 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 122
L H NIV L++V E +++LVMEY +GG++ DYL A G + E R QI +A++
Sbjct: 107 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 166
Query: 123 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMA 182
H K I+HRDLK +N+LL + + IKIADFGF+ T CGSP Y A
Sbjct: 167 HQKFIVHRDLKAENLLLD---------ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217
Query: 183 PEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
PE+ + YD + D+WS+G ++Y + G PF + ++LR E+ IP S
Sbjct: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR---ERVLRGKYRIPFYMS 274
Query: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 274
NLL L N R E ++ G
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVG 307
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 152 bits (383), Expect = 2e-36
Identities = 99/273 (36%), Positives = 143/273 (52%), Gaps = 17/273 (6%)
Query: 4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKE 62
+G++ K +G G FA V RH T EVA+K I+K L+ S + L +E++I+K
Sbjct: 50 IGNYRLLKT--IGKGNFAKVKLARHIL-TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKV 106
Query: 63 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 122
L H NIV L++V E +++LVMEY +GG++ DYL A G + E R QI +A++
Sbjct: 107 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 166
Query: 123 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMA 182
H K I+HRDLK +N+LL + + IKIADFGF+ T CGSP Y A
Sbjct: 167 HQKFIVHRDLKAENLLLD---------ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217
Query: 183 PEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
PE+ + YD + D+WS+G ++Y + G PF + ++LR E+ IP S
Sbjct: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR---ERVLRGKYRIPFYMS 274
Query: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 274
NLL L N R E ++ G
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVG 307
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 152 bits (383), Expect = 2e-36
Identities = 99/273 (36%), Positives = 143/273 (52%), Gaps = 17/273 (6%)
Query: 4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKE 62
+G++ K +G G FA V RH T EVA+K I+K L+ S + L +E++I+K
Sbjct: 17 IGNYRLLKT--IGKGNFAKVKLARHIL-TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKV 73
Query: 63 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 122
L H NIV L++V E +++LVMEY +GG++ DYL A G + E R QI +A++
Sbjct: 74 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 133
Query: 123 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMA 182
H K I+HRDLK +N+LL + + IKIADFGF+ T CGSP Y A
Sbjct: 134 HQKFIVHRDLKAENLLLD---------ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 184
Query: 183 PEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
PE+ + YD + D+WS+G ++Y + G PF + ++LR E+ IP S
Sbjct: 185 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR---ERVLRGKYRIPFYMS 241
Query: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 274
NLL L N R E ++ G
Sbjct: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVG 274
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 152 bits (383), Expect = 2e-36
Identities = 98/268 (36%), Positives = 140/268 (52%), Gaps = 15/268 (5%)
Query: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKELQHEN 67
Y + +G G FA V RH T EVA+K I+K L+ + + L +E++I+K L H N
Sbjct: 60 YRLQKTIGKGNFAKVKLARH-VLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 118
Query: 68 IVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGI 127
IV L++V E +++LVMEY +GG++ DYL A G + E R QI +A++ H K I
Sbjct: 119 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 178
Query: 128 IHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIM 187
+HRDLK +N+LL + IKIADFGF+ T CGSP Y APE+
Sbjct: 179 VHRDLKAENLLLD---------GDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQ 229
Query: 188 SQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLAN 246
+ YD + D+WS+G ++Y + G PF + ++LR E+ IP S N
Sbjct: 230 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR---ERVLRGKYRIPFYMSTDCEN 286
Query: 247 LLLGLLQRNQKDRMDFEAFFSHPFLEQG 274
LL LL N R E ++ G
Sbjct: 287 LLKKLLVLNPIKRGSLEQIMKDRWMNVG 314
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 151 bits (381), Expect = 4e-36
Identities = 94/273 (34%), Positives = 144/273 (52%), Gaps = 17/273 (6%)
Query: 4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKE 62
+G +E + +G G FAVV R H T +VAIK I+K L + + + +E++I+K
Sbjct: 5 IGYYEIDRT--IGKGNFAVVKRATHLV-TKAKVAIKIIDKTQLDEENLKKIFREVQIMKM 61
Query: 63 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 122
L H +I+ LY V E ++LV EY +GG++ D+L A G ++E R QI A+
Sbjct: 62 LCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFC 121
Query: 123 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMA 182
H + I+HRDLK +N+LL + + IKIADFGF+ + T CGSP Y A
Sbjct: 122 HCRNIVHRDLKAENLLLD---------ANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAA 172
Query: 183 PEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
PE+ + YD K D+WS+G V+Y + G PF ++ Q+LR + IP S
Sbjct: 173 PELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKF---RIPFFMS 229
Query: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 274
+L+ +L + R+ E H +++ G
Sbjct: 230 TECEHLIRHMLVLDPNKRLSMEQICKHKWMKLG 262
Score = 30.4 bits (67), Expect = 9.0
Identities = 60/273 (21%), Positives = 98/273 (35%), Gaps = 62/273 (22%)
Query: 252 LQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSPSC--------- 302
L++ Q+ M ++ H L+Q CP P S + ++C + P+
Sbjct: 613 LEKTQQQHMLYQQEQHHQILQQQIQDSICP---PQPSPPLQ-AACENQPALLTHQLQRLR 668
Query: 303 -RFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNIS 361
+ +SPP H+ + +SPP P + + A++SS+ + +
Sbjct: 669 IQPSSPPPNHPNNHLFRQPSNSPP--PMSSAMIQPHGAASSSQFQGLPSRSAIFQ----Q 722
Query: 362 SDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTSTA 421
+C P A L C G QP S V Q++ + N+ TA
Sbjct: 723 QPENCSSPPNVA--------LTCLGMQQPAQSQQ-------VTIQVQEPVDMLSNMPGTA 767
Query: 422 --SSGTNVHGSPRSAVVRRSN-TSPMGFLRPGS---CSPVPADTAQTVGRRL-------- 467
SSG + SP + ++ + T+ M L G + AD+A+ +
Sbjct: 768 AGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANY 827
Query: 468 -------------STGSSRPYSPSPLVGTIPEQ 487
S GS YSPS VG P Q
Sbjct: 828 DQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQ 860
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 149 bits (376), Expect = 1e-35
Identities = 89/245 (36%), Positives = 133/245 (54%), Gaps = 13/245 (5%)
Query: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI 68
Y R+ +G GAF+ V + R VA+K I KK L + L+ EI +L+ + H NI
Sbjct: 32 YEIRERLGSGAFSEVVLAQERGSAHL-VALKCIPKKALRGKEALVENEIAVLRRISHPNI 90
Query: 69 VALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGII 128
VAL DV E P+ ++L ME GG+L D + +G+ +E + Q+ A+ LHS GI+
Sbjct: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
Query: 129 HRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMS 188
HRDLKP+N+L YA + S +I ++DFG ++ NM+ T CG+P Y+APE++
Sbjct: 151 HRDLKPENLL--YATPFEDS----KIMVSDFGLSKIQAGNML-GTACGTPGYVAPELLEQ 203
Query: 189 QHYDAKADLWSIGTVIYQCLVGKPPFQANS-----PQDLRMFYEKNRSLMPSIPRETSPY 243
+ Y D+W++G + Y L G PPF S Q LR YE + I +
Sbjct: 204 KPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDF 263
Query: 244 LANLL 248
+ +LL
Sbjct: 264 IRHLL 268
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 149 bits (376), Expect = 1e-35
Identities = 89/245 (36%), Positives = 133/245 (54%), Gaps = 13/245 (5%)
Query: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI 68
Y R+ +G GAF+ V + R VA+K I KK L + L+ EI +L+ + H NI
Sbjct: 98 YEIRERLGSGAFSEVVLAQERGSAHL-VALKCIPKKALRGKEALVENEIAVLRRISHPNI 156
Query: 69 VALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGII 128
VAL DV E P+ ++L ME GG+L D + +G+ +E + Q+ A+ LHS GI+
Sbjct: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216
Query: 129 HRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMS 188
HRDLKP+N+L YA + S +I ++DFG ++ NM+ T CG+P Y+APE++
Sbjct: 217 HRDLKPENLL--YATPFEDS----KIMVSDFGLSKIQAGNML-GTACGTPGYVAPELLEQ 269
Query: 189 QHYDAKADLWSIGTVIYQCLVGKPPFQANS-----PQDLRMFYEKNRSLMPSIPRETSPY 243
+ Y D+W++G + Y L G PPF S Q LR YE + I +
Sbjct: 270 KPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDF 329
Query: 244 LANLL 248
+ +LL
Sbjct: 330 IRHLL 334
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 149 bits (375), Expect = 2e-35
Identities = 93/284 (32%), Positives = 150/284 (52%), Gaps = 17/284 (5%)
Query: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQI-LLGKEIKILKELQHEN 67
Y +G G FAVV RH T +VA+K I+K L L +E++ +K +QH N
Sbjct: 16 YDLDKTLGRGHFAVVKLARH-VFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPN 74
Query: 68 IVALYDVQELPNSVFLVMEYCNGGDLADY-LQAKGTLSEDTIRVFLHQIAAAMRILHSKG 126
IV LY+V + ++L++E +GGD+ DY ++ + L+ED + + QI A+ H
Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134
Query: 127 IIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVI 186
++HRDLKP+N++ K + +K+ DFGF+ T CGS Y APE++
Sbjct: 135 VVHRDLKPENVVFF----EKQGL----VKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEIL 186
Query: 187 MSQHYDAKA-DLWSIGTVIYQCLVGKPPFQ-ANSPQDLRMFYEKNRSLMPSIPRETSPYL 244
+ YDA A D+WS+G +++ + G+PPFQ AN + L M + ++P S
Sbjct: 187 LGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD----CKYTVPSHVSKEC 242
Query: 245 ANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYS 288
+L+ +LQR+ K R E +HP+L+ + +P+ S
Sbjct: 243 KDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVS 286
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 149 bits (375), Expect = 2e-35
Identities = 93/284 (32%), Positives = 150/284 (52%), Gaps = 17/284 (5%)
Query: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQI-LLGKEIKILKELQHEN 67
Y +G G FAVV RH T +VA+K I+K L L +E++ +K +QH N
Sbjct: 16 YDLDKTLGRGHFAVVKLARH-VFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPN 74
Query: 68 IVALYDVQELPNSVFLVMEYCNGGDLADY-LQAKGTLSEDTIRVFLHQIAAAMRILHSKG 126
IV LY+V + ++L++E +GGD+ DY ++ + L+ED + + QI A+ H
Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134
Query: 127 IIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVI 186
++HRDLKP+N++ K + +K+ DFGF+ T CGS Y APE++
Sbjct: 135 VVHRDLKPENVVFF----EKQGL----VKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEIL 186
Query: 187 MSQHYDAKA-DLWSIGTVIYQCLVGKPPFQ-ANSPQDLRMFYEKNRSLMPSIPRETSPYL 244
+ YDA A D+WS+G +++ + G+PPFQ AN + L M + ++P S
Sbjct: 187 LGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD----CKYTVPSHVSKEC 242
Query: 245 ANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYS 288
+L+ +LQR+ K R E +HP+L+ + +P+ S
Sbjct: 243 KDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVS 286
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 149 bits (375), Expect = 2e-35
Identities = 98/273 (35%), Positives = 143/273 (52%), Gaps = 17/273 (6%)
Query: 4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKE 62
+G++ K +G G FA V RH T EVAIK I+K L+ + + L +E++I+K
Sbjct: 53 IGNYRLLKT--IGKGNFAKVKLARHIL-TGREVAIKIIDKTQLNPTSLQKLFREVRIMKI 109
Query: 63 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 122
L H NIV L++V E +++L+MEY +GG++ DYL A G + E R QI +A++
Sbjct: 110 LNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 123 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMA 182
H K I+HRDLK +N+LL + + IKIADFGF+ T CGSP Y A
Sbjct: 170 HQKRIVHRDLKAENLLLD---------ADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220
Query: 183 PEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
PE+ + YD + D+WS+G ++Y + G PF + ++LR E+ IP S
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR---ERVLRGKYRIPFYMS 277
Query: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 274
NLL L N R E ++ G
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWINAG 310
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 149 bits (375), Expect = 2e-35
Identities = 98/273 (35%), Positives = 143/273 (52%), Gaps = 17/273 (6%)
Query: 4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKE 62
+G++ K +G G FA V RH T EVAIK I+K L+ + + L +E++I+K
Sbjct: 53 IGNYRLLKT--IGKGNFAKVKLARHIL-TGREVAIKIIDKTQLNPTSLQKLFREVRIMKI 109
Query: 63 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 122
L H NIV L++V E +++L+MEY +GG++ DYL A G + E R QI +A++
Sbjct: 110 LNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 123 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMA 182
H K I+HRDLK +N+LL + + IKIADFGF+ T CGSP Y A
Sbjct: 170 HQKRIVHRDLKAENLLLD---------ADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220
Query: 183 PEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
PE+ + YD + D+WS+G ++Y + G PF + ++LR E+ IP S
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR---ERVLRGKYRIPFYMS 277
Query: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 274
NLL L N R E ++ G
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWINAG 310
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 149 bits (375), Expect = 2e-35
Identities = 98/273 (35%), Positives = 143/273 (52%), Gaps = 17/273 (6%)
Query: 4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKE 62
+G++ K +G G FA V RH T EVAIK I+K L+ + + L +E++I+K
Sbjct: 53 IGNYRLLKT--IGKGNFAKVKLARHIL-TGREVAIKIIDKTQLNPTSLQKLFREVRIMKI 109
Query: 63 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 122
L H NIV L++V E +++L+MEY +GG++ DYL A G + E R QI +A++
Sbjct: 110 LNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 123 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMA 182
H K I+HRDLK +N+LL + + IKIADFGF+ T CGSP Y A
Sbjct: 170 HQKRIVHRDLKAENLLLD---------ADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220
Query: 183 PEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
PE+ + YD + D+WS+G ++Y + G PF + ++LR E+ IP S
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR---ERVLRGKYRIPFYMS 277
Query: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 274
NLL L N R E ++ G
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWINAG 310
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,923,871
Number of Sequences: 37866
Number of extensions: 2358929
Number of successful extensions: 13539
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 674
Number of HSP's successfully gapped in prelim test: 395
Number of HSP's that attempted gapping in prelim test: 10010
Number of HSP's gapped (non-prelim): 2362
length of query: 1036
length of database: 18,247,518
effective HSP length: 112
effective length of query: 924
effective length of database: 14,006,526
effective search space: 12942030024
effective search space used: 12942030024
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.