Search of human proteins with 217272867

Search of human proteins with 217272867

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|217272867 solute carrier family 26, member 9 isoform b [Homo
sapiens]
         (887 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|217272867 solute carrier family 26, member 9 isoform b [Homo ...  1757   0.0  
gi|16418413 solute carrier family 26, member 9 isoform a [Homo s...  1568   0.0  
gi|217272870 solute carrier family 26, member 9 isoform c [Homo ...   914   0.0  
gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo s...   504   e-142
gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo s...   504   e-142
gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo s...   502   e-142
gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo s...   495   e-140
gi|39752683 prestin isoform a [Homo sapiens]                          492   e-139
gi|45827800 prestin isoform b [Homo sapiens]                          467   e-131
gi|4505697 pendrin [Homo sapiens]                                     459   e-129
gi|4557535 solute carrier family 26, member 3 [Homo sapiens]          439   e-123
gi|45827802 prestin isoform c [Homo sapiens]                          388   e-107
gi|100913030 solute carrier family 26 member 2 [Homo sapiens]         358   1e-98
gi|16418457 solute carrier family 26, member 8 isoform a [Homo s...   308   2e-83
gi|47131207 solute carrier family 26, member 1 isoform a [Homo s...   302   1e-81
gi|20336272 solute carrier family 26, member 1 isoform a [Homo s...   302   1e-81
gi|16306483 solute carrier family 26, member 7 isoform a [Homo s...   278   1e-74
gi|20336282 solute carrier family 26, member 7 isoform b [Homo s...   278   1e-74
gi|45827804 prestin isoform d [Homo sapiens]                          243   7e-64
gi|65506789 solute carrier family 26, member 10 [Homo sapiens]        228   2e-59
gi|20336285 solute carrier family 26, member 8 isoform b [Homo s...   179   1e-44
gi|85540447 solute carrier family 26, member 11 [Homo sapiens]        134   5e-31
gi|20336274 solute carrier family 26, member 1 isoform b [Homo s...    81   4e-15
gi|119943102 CREB binding protein isoform b [Homo sapiens]             35   0.24 
gi|119943104 CREB binding protein isoform a [Homo sapiens]             35   0.24 
gi|150170729 microtubule associated serine/threonine kinase 3 [H...    34   0.69 
gi|50054477 olfactory receptor, family 5, subfamily AS, member 1...    34   0.69 
gi|122891870 melanoma inhibitory activity family, member 3 [Homo...    33   0.90 
gi|157743257 POU domain, class 6, transcription factor 2 [Homo s...    33   0.90 
gi|226498466 T-cell immunoglobulin and mucin domain containing 4...    33   1.2  

>gi|217272867 solute carrier family 26, member 9 isoform b [Homo
           sapiens]
          Length = 887

 Score = 1757 bits (4551), Expect = 0.0
 Identities = 887/887 (100%), Positives = 887/887 (100%)

Query: 1   MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS 60
           MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS
Sbjct: 1   MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS 60

Query: 61  WLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV 120
           WLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV
Sbjct: 61  WLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV 120

Query: 121 HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT 180
           HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT
Sbjct: 121 HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT 180

Query: 181 AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT 240
           AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT
Sbjct: 181 AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT 240

Query: 241 FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG 300
           FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG
Sbjct: 241 FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG 300

Query: 301 CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG 360
           CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG
Sbjct: 301 CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG 360

Query: 361 YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML 420
           YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML
Sbjct: 361 YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML 420

Query: 421 VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPY 480
           VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPY
Sbjct: 421 VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPY 480

Query: 481 GVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYF 540
           GVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYF
Sbjct: 481 GVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYF 540

Query: 541 ANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQ 600
           ANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQ
Sbjct: 541 ANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQ 600

Query: 601 DFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFV 660
           DFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFV
Sbjct: 601 DFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFV 660

Query: 661 TFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS 720
           TFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS
Sbjct: 661 TFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS 720

Query: 721 LECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFG 780
           LECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFG
Sbjct: 721 LECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFG 780

Query: 781 SMFHAETLTALESLSAAGGCYPYRSESLVSPLFTRQALAAMDKPPAHSTPPTSALSLAAE 840
           SMFHAETLTALESLSAAGGCYPYRSESLVSPLFTRQALAAMDKPPAHSTPPTSALSLAAE
Sbjct: 781 SMFHAETLTALESLSAAGGCYPYRSESLVSPLFTRQALAAMDKPPAHSTPPTSALSLAAE 840

Query: 841 GHLDFQLLRVSQKQKDKYNCAGLLYKLQKVSQSPHGSVSDGVRLSRT 887
           GHLDFQLLRVSQKQKDKYNCAGLLYKLQKVSQSPHGSVSDGVRLSRT
Sbjct: 841 GHLDFQLLRVSQKQKDKYNCAGLLYKLQKVSQSPHGSVSDGVRLSRT 887


>gi|16418413 solute carrier family 26, member 9 isoform a [Homo
           sapiens]
          Length = 791

 Score = 1568 bits (4061), Expect = 0.0
 Identities = 791/791 (100%), Positives = 791/791 (100%)

Query: 1   MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS 60
           MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS
Sbjct: 1   MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLS 60

Query: 61  WLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV 120
           WLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV
Sbjct: 61  WLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGV 120

Query: 121 HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT 180
           HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT
Sbjct: 121 HQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLT 180

Query: 181 AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT 240
           AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT
Sbjct: 181 AIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFT 240

Query: 241 FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG 300
           FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG
Sbjct: 241 FIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGG 300

Query: 301 CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG 360
           CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG
Sbjct: 301 CKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHG 360

Query: 361 YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML 420
           YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML
Sbjct: 361 YDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITML 420

Query: 421 VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPY 480
           VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPY
Sbjct: 421 VLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPY 480

Query: 481 GVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYF 540
           GVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYF
Sbjct: 481 GVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYF 540

Query: 541 ANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQ 600
           ANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQ
Sbjct: 541 ANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQ 600

Query: 601 DFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFV 660
           DFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFV
Sbjct: 601 DFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFV 660

Query: 661 TFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS 720
           TFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS
Sbjct: 661 TFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS 720

Query: 721 LECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFG 780
           LECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFG
Sbjct: 721 LECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFG 780

Query: 781 SMFHAETLTAL 791
           SMFHAETLTAL
Sbjct: 781 SMFHAETLTAL 791


>gi|217272870 solute carrier family 26, member 9 isoform c [Homo
           sapiens]
          Length = 459

 Score =  914 bits (2361), Expect = 0.0
 Identities = 459/459 (100%), Positives = 459/459 (100%)

Query: 333 MIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALS 392
           MIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALS
Sbjct: 1   MIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALS 60

Query: 393 VTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDP 452
           VTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDP
Sbjct: 61  VTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDP 120

Query: 453 YYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTD 512
           YYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTD
Sbjct: 121 YYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTD 180

Query: 513 IYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQ 572
           IYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQ
Sbjct: 181 IYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQ 240

Query: 573 EKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDSS 632
           EKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDSS
Sbjct: 241 EKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDSS 300

Query: 633 SPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGK 692
           SPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGK
Sbjct: 301 SPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGK 360

Query: 693 IGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDVTPGHNFQG 752
           IGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDVTPGHNFQG
Sbjct: 361 IGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDVTPGHNFQG 420

Query: 753 APGDAELSLYDSEEDIRSYWDLEQEMFGSMFHAETLTAL 791
           APGDAELSLYDSEEDIRSYWDLEQEMFGSMFHAETLTAL
Sbjct: 421 APGDAELSLYDSEEDIRSYWDLEQEMFGSMFHAETLTAL 459


>gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo
           sapiens]
          Length = 738

 Score =  504 bits (1298), Expect = e-142
 Identities = 265/713 (37%), Positives = 433/713 (60%), Gaps = 14/713 (1%)

Query: 32  PVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMA 91
           P   + R   +CS A+  A++   LPVL WLP+Y ++D+++ DLL GLS   +Q+PQG+A
Sbjct: 30  PRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLA 89

Query: 92  FALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVF 151
           +ALLA LP V GLYSSF+P+  YF  G    +  GTFAV+S++VG++   LAP+      
Sbjct: 90  YALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ------ 143

Query: 152 NNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAA 211
             A N+S ++  A +A R+ V++TL+ L  + Q+GLG + FGFV  YLSE  +RG+ TAA
Sbjct: 144 --ALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAA 201

Query: 212 GLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKE 271
            +Q+ +S LKY+FGL + S++GP S+++T +++C  LP + + +++ A ++G  LV+VK 
Sbjct: 202 AVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKL 261

Query: 272 LNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWK 331
           LN +   ++  PIP E++ ++ AT IS G  +  ++ + +VG I  G   PV+P    + 
Sbjct: 262 LNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFS 321

Query: 332 DMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCAL 391
            ++G+AF++A+V + I +++G+  A +HGY VDSNQE++ALG SN  G  F+   + C++
Sbjct: 322 KLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSM 381

Query: 392 SVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTD 451
           S +L  +  GG SQVA    SL +++ ++ LG   + LPK+VL A+I VNLK  L+QL+D
Sbjct: 382 SRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSD 441

Query: 452 PYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDT 511
              LW+ ++ D  IW+V+F ++  L+L  G+ V V FS+L+VV +TQ  +   L QV DT
Sbjct: 442 MRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDT 501

Query: 512 DIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKK 571
           DIY +   Y+ A++++G+K+    + +YFAN+E +   +  + G+D   ++  K+K LKK
Sbjct: 502 DIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKK 561

Query: 572 QEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDS 631
           QE+ +++  Q+   L  +  +     +  +   +     +NN        VS    S D 
Sbjct: 562 QEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVS----SGDK 617

Query: 632 SSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYG 691
              A +     ++AP + S + A   P   FH+LILD+  +SFVD + +K+L  +   + 
Sbjct: 618 MEDATANGQEDSKAP-DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFR 676

Query: 692 KIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDV 744
           +I V+V++   H+ V + +  G  F D S+  KH+F S+HDAV FA  + R V
Sbjct: 677 EIEVEVYMAACHSPVVSQLEAGHFF-DASITKKHLFASVHDAVTFALQHPRPV 728


>gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo
           sapiens]
          Length = 759

 Score =  504 bits (1298), Expect = e-142
 Identities = 265/713 (37%), Positives = 433/713 (60%), Gaps = 14/713 (1%)

Query: 32  PVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMA 91
           P   + R   +CS A+  A++   LPVL WLP+Y ++D+++ DLL GLS   +Q+PQG+A
Sbjct: 51  PRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLA 110

Query: 92  FALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVF 151
           +ALLA LP V GLYSSF+P+  YF  G    +  GTFAV+S++VG++   LAP+      
Sbjct: 111 YALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ------ 164

Query: 152 NNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAA 211
             A N+S ++  A +A R+ V++TL+ L  + Q+GLG + FGFV  YLSE  +RG+ TAA
Sbjct: 165 --ALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAA 222

Query: 212 GLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKE 271
            +Q+ +S LKY+FGL + S++GP S+++T +++C  LP + + +++ A ++G  LV+VK 
Sbjct: 223 AVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKL 282

Query: 272 LNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWK 331
           LN +   ++  PIP E++ ++ AT IS G  +  ++ + +VG I  G   PV+P    + 
Sbjct: 283 LNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFS 342

Query: 332 DMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCAL 391
            ++G+AF++A+V + I +++G+  A +HGY VDSNQE++ALG SN  G  F+   + C++
Sbjct: 343 KLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSM 402

Query: 392 SVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTD 451
           S +L  +  GG SQVA    SL +++ ++ LG   + LPK+VL A+I VNLK  L+QL+D
Sbjct: 403 SRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSD 462

Query: 452 PYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDT 511
              LW+ ++ D  IW+V+F ++  L+L  G+ V V FS+L+VV +TQ  +   L QV DT
Sbjct: 463 MRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDT 522

Query: 512 DIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKK 571
           DIY +   Y+ A++++G+K+    + +YFAN+E +   +  + G+D   ++  K+K LKK
Sbjct: 523 DIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKK 582

Query: 572 QEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDS 631
           QE+ +++  Q+   L  +  +     +  +   +     +NN        VS    S D 
Sbjct: 583 QEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVS----SGDK 638

Query: 632 SSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYG 691
              A +     ++AP + S + A   P   FH+LILD+  +SFVD + +K+L  +   + 
Sbjct: 639 MEDATANGQEDSKAP-DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFR 697

Query: 692 KIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDV 744
           +I V+V++   H+ V + +  G  F D S+  KH+F S+HDAV FA  + R V
Sbjct: 698 EIEVEVYMAACHSPVVSQLEAGHFF-DASITKKHLFASVHDAVTFALQHPRPV 749


>gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo
           sapiens]
          Length = 758

 Score =  502 bits (1293), Expect = e-142
 Identities = 265/713 (37%), Positives = 433/713 (60%), Gaps = 15/713 (2%)

Query: 32  PVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMA 91
           P   + R   +CS A+  A++   LPVL WLP+Y ++D+++ DLL GLS   +Q+PQG+A
Sbjct: 51  PRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLA 110

Query: 92  FALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVF 151
           +ALLA LP V GLYSSF+P+  YF  G    +  GTFAV+S++VG++   LAP+      
Sbjct: 111 YALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ------ 164

Query: 152 NNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAA 211
             A N+S ++  A +A R+ V++TL+ L  + Q+GLG + FGFV  YLSE  +RG+ TAA
Sbjct: 165 --ALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAA 222

Query: 212 GLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKE 271
            +Q+ +S LKY+FGL + S++GP S+++T +++C  LP + + +++ A ++G  LV+VK 
Sbjct: 223 AVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKL 282

Query: 272 LNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWK 331
           LN +   ++  PIP E++ ++ AT IS G  +  ++ + +VG I  G   PV+P    + 
Sbjct: 283 LNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFS 342

Query: 332 DMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCAL 391
            ++G+AF++A+V + I +++G+  A +HGY VDSNQE++ALG SN  G  F+   + C++
Sbjct: 343 KLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSM 402

Query: 392 SVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTD 451
           S +L  +  GG SQVA    SL +++ ++ LG   + LPK+VL A+I VNLK  L+QL+D
Sbjct: 403 SRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSD 462

Query: 452 PYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDT 511
              LW+ ++ D  IW+V+F ++  L+L  G+ V V FS+L+VV +TQ  +   L QV DT
Sbjct: 463 MRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDT 522

Query: 512 DIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKK 571
           DIY +   Y+ A++++G+K+    + +YFAN+E +   +  + G+D   ++  K+K LKK
Sbjct: 523 DIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKK 582

Query: 572 QEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDS 631
           QE+ +++  Q+   L  +  +     +  +  N    D  +N    N      +  S D 
Sbjct: 583 QEQLKLKQLQKEEKLRKQAASPKGASVSINV-NTSLEDMRSN----NVEDCKMMVSSGDK 637

Query: 632 SSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYG 691
              A +     ++AP + S + A   P   FH+LILD+  +SFVD + +K+L  +   + 
Sbjct: 638 MEDATANGQEDSKAP-DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFR 696

Query: 692 KIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDV 744
           +I V+V++   H+ V + +  G  F D S+  KH+F S+HDAV FA  + R V
Sbjct: 697 EIEVEVYMAACHSPVVSQLEAGHFF-DASITKKHLFASVHDAVTFALQHPRPV 748


>gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo
           sapiens]
          Length = 740

 Score =  495 bits (1274), Expect = e-140
 Identities = 265/713 (37%), Positives = 431/713 (60%), Gaps = 33/713 (4%)

Query: 32  PVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMA 91
           P   + R   +CS A+  A++   LPVL WLP+Y ++D+++ DLL GLS   +Q+PQG+A
Sbjct: 51  PRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLA 110

Query: 92  FALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVF 151
           +ALLA LP V GLYSSF+P+  YF  G    +  GTFAV+S++VG++   LAP+      
Sbjct: 111 YALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ------ 164

Query: 152 NNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAA 211
             A N+S ++  A +A R+ V++TL+ L  + Q+GLG + FGFV  YLSE  +RG+ TAA
Sbjct: 165 --ALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAA 222

Query: 212 GLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKE 271
            +Q+ +S LKY+FGL + S++GP S+++T +++C  LP + + +++ A ++G  LV+VK 
Sbjct: 223 AVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKL 282

Query: 272 LNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWK 331
           LN +   ++  PIP E++ ++ AT IS G  +  ++ + +VG I  G   PV+P    + 
Sbjct: 283 LNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFS 342

Query: 332 DMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCAL 391
            ++G+AF++A+V + I +++G+  A +HGY VDSNQE++ALG SN  G  F+   + C++
Sbjct: 343 KLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSM 402

Query: 392 SVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTD 451
           S +L  +  GG SQVA    SL +++ ++ LG   + LPK+VL A+I VNLK  L+QL+D
Sbjct: 403 SRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSD 462

Query: 452 PYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDT 511
              LW+ ++ D  IW+V+F ++  L+L  G+ V V FS+L+VV +TQ  +   L QV DT
Sbjct: 463 MRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDT 522

Query: 512 DIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKK 571
           DIY +   Y+ A++++G+K+    + +YFAN+E +   +  + G+D   ++  K+K LKK
Sbjct: 523 DIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKK 582

Query: 572 QEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDS 631
           QE+ +++  Q+   L  +   +    L      AP       Q  ++G          D 
Sbjct: 583 QEQLKLKQLQKEEKLRKQAGPLLSACL------AP-------QQVSSG----------DK 619

Query: 632 SSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYG 691
              A +     ++AP + S + A   P   FH+LILD+  +SFVD + +K+L  +   + 
Sbjct: 620 MEDATANGQEDSKAP-DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFR 678

Query: 692 KIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDV 744
           +I V+V++   H+ V + +  G  F D S+  KH+F S+HDAV FA  + R V
Sbjct: 679 EIEVEVYMAACHSPVVSQLEAGHFF-DASITKKHLFASVHDAVTFALQHPRPV 730


>gi|39752683 prestin isoform a [Homo sapiens]
          Length = 744

 Score =  492 bits (1266), Expect = e-139
 Identities = 273/764 (35%), Positives = 437/764 (57%), Gaps = 47/764 (6%)

Query: 7   RYVVDRAAYSLTLFDDEFEKKDRTYP-VGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKY 65
           RY V+R  +S  +  +    KD+    + +KL+ AF C+  KI+ +++  LP+  WLP Y
Sbjct: 15  RYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAY 74

Query: 66  KIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVP 125
           K K+Y++ DL+ G+S G +Q+PQG+AFA+LA +P + GLYSSF+P++ Y FLG    +  
Sbjct: 75  KFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISI 134

Query: 126 GTFAVISILVGNICLQLAPESKFQVFN-NATNESYVDTAAMEAERLHVSATLACLTAIIQ 184
           G FAVIS+++G + ++L P+        NATN     T A +A R+ V+ ++  L+ IIQ
Sbjct: 135 GPFAVISLMIGGVAVRLVPDDIVIPGGVNATN----GTEARDALRVKVAMSVTLLSGIIQ 190

Query: 185 MGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDI 244
             LG  +FGFVAIYL+E  +RGF TAA + +  S+LKY+FG+    Y+G  S+V++ + +
Sbjct: 191 FCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAV 250

Query: 245 CKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMP 304
            +N+ + N+ SL   L+    L+  KE N R+  K+  PIP E   VV+ T IS G  + 
Sbjct: 251 LQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLK 310

Query: 305 KKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVD 364
           + Y++ +VG +  G   P +P  S +  +   A ++AIV + + ++M +TLANKHGY VD
Sbjct: 311 ESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVD 370

Query: 365 SNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGI 424
            NQE+IALG  N  GS F+   I C+LS +L  +G GGK+Q+A    SL++++ +L  G 
Sbjct: 371 GNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGF 430

Query: 425 YLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAV 484
               LP++VL A++ VNLK    Q +D  + WR SK++  IW+ +F+SS FL L YG+  
Sbjct: 431 LFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLIT 490

Query: 485 GVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSE 544
            V  ++L V+++TQ  +   L ++ +TD+Y++   Y   ++I GIKI    +P+Y+ANS+
Sbjct: 491 AVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSD 550

Query: 545 IFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFEN 604
           ++   +  KTG++P  ++ A++K ++K  K       +  +  M   TV   + + D E+
Sbjct: 551 LYSNALKRKTGVNPAVIMGARRKAMRKYAK-------EVGNANMANATVVKADAEVDGED 603

Query: 605 APPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHT 664
           A                       P+        PP   ++   P +M   +PP    HT
Sbjct: 604 AT---------------------KPEEEDGEVKYPPIVIKST-FPEEMQRFMPPGDNVHT 641

Query: 665 LILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECK 724
           +ILD + V+F+D +G+K LA +   YG +G+ V+L    AQV ND++    FE+ +L  +
Sbjct: 642 VILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPAL-WE 700

Query: 725 HVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDI 768
            +F SIHDAVL           G   + A  + E S   S+ED+
Sbjct: 701 LLFHSIHDAVL-----------GSQLREALAEQEASAPPSQEDL 733


>gi|45827800 prestin isoform b [Homo sapiens]
          Length = 685

 Score =  467 bits (1202), Expect = e-131
 Identities = 251/700 (35%), Positives = 405/700 (57%), Gaps = 35/700 (5%)

Query: 7   RYVVDRAAYSLTLFDDEFEKKDRTYP-VGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKY 65
           RY V+R  +S  +  +    KD+    + +KL+ AF C+  KI+ +++  LP+  WLP Y
Sbjct: 15  RYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAY 74

Query: 66  KIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVP 125
           K K+Y++ DL+ G+S G +Q+PQG+AFA+LA +P + GLYSSF+P++ Y FLG    +  
Sbjct: 75  KFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISI 134

Query: 126 GTFAVISILVGNICLQLAPESKFQVFN-NATNESYVDTAAMEAERLHVSATLACLTAIIQ 184
           G FAVIS+++G + ++L P+        NATN     T A +A R+ V+ ++  L+ IIQ
Sbjct: 135 GPFAVISLMIGGVAVRLVPDDIVIPGGVNATN----GTEARDALRVKVAMSVTLLSGIIQ 190

Query: 185 MGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDI 244
             LG  +FGFVAIYL+E  +RGF TAA + +  S+LKY+FG+    Y+G  S+V++ + +
Sbjct: 191 FCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAV 250

Query: 245 CKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMP 304
            +N+ + N+ SL   L+    L+  KE N R+  K+  PIP E   VV+ T IS G  + 
Sbjct: 251 LQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLK 310

Query: 305 KKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVD 364
           + Y++ +VG +  G   P +P  S +  +   A ++AIV + + ++M +TLANKHGY VD
Sbjct: 311 ESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVD 370

Query: 365 SNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGI 424
            NQE+IALG  N  GS F+   I C+LS +L  +G GGK+Q+A    SL++++ +L  G 
Sbjct: 371 GNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGF 430

Query: 425 YLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAV 484
               LP++VL A++ VNLK    Q +D  + WR SK++  IW+ +F+SS FL L YG+  
Sbjct: 431 LFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLIT 490

Query: 485 GVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSE 544
            V  ++L V+++TQ  +   L ++ +TD+Y++   Y   ++I GIKI    +P+Y+ANS+
Sbjct: 491 AVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSD 550

Query: 545 IFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFEN 604
           ++   +  KTG++P  ++ A++K ++K  K       +  +  M   TV   + + D E+
Sbjct: 551 LYSNALKRKTGVNPAVIMGARRKAMRKYAK-------EVGNANMANATVVKADAEVDGED 603

Query: 605 APPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHT 664
           A                       P+        PP   ++   P +M   +PP    HT
Sbjct: 604 AT---------------------KPEEEDGEVKYPPIVIKST-FPEEMQRFMPPGDNVHT 641

Query: 665 LILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHA 704
           +ILD + V+F+D +G+K LA +   YG +G+ V+L    A
Sbjct: 642 VILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSA 681


>gi|4505697 pendrin [Homo sapiens]
          Length = 780

 Score =  459 bits (1180), Expect = e-129
 Identities = 259/739 (35%), Positives = 409/739 (55%), Gaps = 36/739 (4%)

Query: 8   YVVDRAAYSLTLFDDEFEKK-DRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYK 66
           Y+V R  YS   F  + E++      + E L     CS  +   V+  L+P+L WLPKY+
Sbjct: 20  YMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYR 79

Query: 67  IKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPG 126
           +K++++ D++ G+S G +   QGMA+ALLA +P   GLYS+FFP+LTYF  G    +  G
Sbjct: 80  VKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVG 139

Query: 127 TFAVISILVGNICLQLAPESKFQVFNN---ATNESYVDTAAMEAERLHVSATLACLTAII 183
            F V+S++VG++ L +AP+  F V ++     N + +DTAA +  R+ +++ L  L  II
Sbjct: 140 PFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGII 199

Query: 184 QMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFID 243
           Q+  G +Q GF+  YL++  + GF TAA  Q+L+S LK +  ++  +Y G  SI++T ++
Sbjct: 200 QLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVE 259

Query: 244 ICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKM 303
           I +N+  TN+A     L++    + VKELN R+ HKI  PIP E+IV ++ATAIS G  +
Sbjct: 260 IFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANL 319

Query: 304 PKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDV 363
            K Y+  IV  I RGF  P  P VS + +M+  +FS+A+V+Y I +++G+  A K+ Y +
Sbjct: 320 EKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTI 379

Query: 364 DSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLG 423
           D NQE IA G SN F  FF   V   ALS T   +  GGK+QVA +  + +VMI +L LG
Sbjct: 380 DGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALG 439

Query: 424 IYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVA 483
             L PL KSVL A++  NLK    QL D   LWR++K+D  IWV + + S  L L  G+ 
Sbjct: 440 KLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLL 499

Query: 484 VGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANS 543
            G+ F +L VV + QF +   L  +  TDIY + K Y   ++ QG+KI+ + SP+++ N 
Sbjct: 500 AGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNV 559

Query: 544 EIFRQKVIAKTGMDPQKVLLAKQKYLKKQEK----RRMRPTQQRRSLFMKTKTVSLQELQ 599
           + F++ + +  G D  +V   + K L+K +K     ++R T +   +     T +  E  
Sbjct: 560 DGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRAT-KNGIISDAVSTNNAFEPD 618

Query: 600 QDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPF 659
           +D E+    D    +          I    D +    SE P     P  P          
Sbjct: 619 EDIEDLEELDIPTKE----------IEIQVDWN----SELPVKVNVPKVP---------- 654

Query: 660 VTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDG 719
              H+L+LD   +SF+D++G+++L  +   + +I V V+  ++   V   +   G F+D 
Sbjct: 655 --IHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDD- 711

Query: 720 SLECKHVFPSIHDAVLFAQ 738
           ++     F ++HDA+L+ Q
Sbjct: 712 NIRKDTFFLTVHDAILYLQ 730


>gi|4557535 solute carrier family 26, member 3 [Homo sapiens]
          Length = 764

 Score =  439 bits (1128), Expect = e-123
 Identities = 254/737 (34%), Positives = 399/737 (54%), Gaps = 34/737 (4%)

Query: 7   RYVVDRAAYSLTLFDDEFEKKDRTYPVG-EKLRNAFRCSSAKIKAVVFGLLPVLSWLPKY 65
           +Y+V R  YS   F++  +K  R +    + L+    CS  K K +V  L P+ SWLP Y
Sbjct: 8   QYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAY 67

Query: 66  KIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVP 125
           ++K++++ D++ G+S G + V QG+AFALL ++P V GLY+SFFP + Y F G    +  
Sbjct: 68  RLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISV 127

Query: 126 GTFAVISILVG----NICLQLAPESKFQVF---NNATNESYVDTAAMEAERLHVSATLAC 178
           G F ++S++VG        +  P+         NN+ N S +D    E  R+  +A++  
Sbjct: 128 GPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDD---ERVRVAAAASVTV 184

Query: 179 LTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIV 238
           L+ IIQ+  G ++ GFV IYLSES I GF TAA + +L+S LK+IF LT+PS+T P SI 
Sbjct: 185 LSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIF 244

Query: 239 FTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAIS 298
                +   +  TNIA L+ ALI    + +VKE+N R+  K+  PIP E I+ V+A  +S
Sbjct: 245 KVLYSVFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVS 304

Query: 299 GGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANK 358
            GC    ++ + +VG++  GF  P++P V  +++ +G  F +A+V++ +  ++    + K
Sbjct: 305 YGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLK 364

Query: 359 HGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMIT 418
           + Y +D NQE+IALG  N     F+      ALS +   +  GGK+Q+A L  +++V+I 
Sbjct: 365 YDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIV 424

Query: 419 MLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSL 478
           +L +G  L PL KSVL AL   NLK  L Q  +   LWRK K DC IW+++F+ +  L L
Sbjct: 425 VLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGL 484

Query: 479 PYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPL 538
             G+A  VAF +L +VF+TQF     LA +  T+IY N K Y    + +G+KI    SP+
Sbjct: 485 GLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPI 544

Query: 539 YFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQEL 598
           YFAN   FR+K+I   G  P ++L  + K L+K  K       Q++ L   T    +  +
Sbjct: 545 YFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRK------LQKQGLLQVTPKGFICTV 598

Query: 599 QQDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPP 658
               ++    D N  +      + + + F  D +     + P + E P            
Sbjct: 599 DTIKDSDEELDNNQIEVLDQPINTTDLPFHIDWN----DDLPLNIEVPK----------- 643

Query: 659 FVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFED 718
            ++ H+LILD S VSF+D+  ++ L  +   + +I V V++V         ++    F D
Sbjct: 644 -ISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFF-D 701

Query: 719 GSLECKHVFPSIHDAVL 735
           G ++    F +IHDAVL
Sbjct: 702 GEVKSSIFFLTIHDAVL 718


>gi|45827802 prestin isoform c [Homo sapiens]
          Length = 516

 Score =  388 bits (996), Expect = e-107
 Identities = 197/494 (39%), Positives = 307/494 (62%), Gaps = 6/494 (1%)

Query: 7   RYVVDRAAYSLTLFDDEFEKKDRTYP-VGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKY 65
           RY V+R  +S  +  +    KD+    + +KL+ AF C+  KI+ +++  LP+  WLP Y
Sbjct: 15  RYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAY 74

Query: 66  KIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVP 125
           K K+Y++ DL+ G+S G +Q+PQG+AFA+LA +P + GLYSSF+P++ Y FLG    +  
Sbjct: 75  KFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISI 134

Query: 126 GTFAVISILVGNICLQLAPESKFQVFN-NATNESYVDTAAMEAERLHVSATLACLTAIIQ 184
           G FAVIS+++G + ++L P+        NATN     T A +A R+ V+ ++  L+ IIQ
Sbjct: 135 GPFAVISLMIGGVAVRLVPDDIVIPGGVNATN----GTEARDALRVKVAMSVTLLSGIIQ 190

Query: 185 MGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDI 244
             LG  +FGFVAIYL+E  +RGF TAA + +  S+LKY+FG+    Y+G  S+V++ + +
Sbjct: 191 FCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAV 250

Query: 245 CKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMP 304
            +N+ + N+ SL   L+    L+  KE N R+  K+  PIP E   VV+ T IS G  + 
Sbjct: 251 LQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLK 310

Query: 305 KKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVD 364
           + Y++ +VG +  G   P +P  S +  +   A ++AIV + + ++M +TLANKHGY VD
Sbjct: 311 ESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVD 370

Query: 365 SNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGI 424
            NQE+IALG  N  GS F+   I C+LS +L  +G GGK+Q+A    SL++++ +L  G 
Sbjct: 371 GNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGF 430

Query: 425 YLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAV 484
               LP++VL A++ VNLK    Q +D  + WR SK++  IW+ +F+SS FL L YG+  
Sbjct: 431 LFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLIT 490

Query: 485 GVAFSVLVVVFQTQ 498
            V  ++L V+++TQ
Sbjct: 491 AVIIALLTVIYRTQ 504


>gi|100913030 solute carrier family 26 member 2 [Homo sapiens]
          Length = 739

 Score =  358 bits (919), Expect = 1e-98
 Identities = 220/730 (30%), Positives = 365/730 (50%), Gaps = 81/730 (11%)

Query: 25  EKKDRTYP--VGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGG 82
           EK D  +   V +KL+   +CS AK K ++ G LPVL WLPKY +K  I+ D++ GL  G
Sbjct: 60  EKSDTNFKEFVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVG 119

Query: 83  SIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQL 142
            + VPQ +A++LLA    V GLY+SFF  + YF LG    +  G F V+ +++G    + 
Sbjct: 120 ILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLCLMIGETVDRE 179

Query: 143 APESKFQVFNNATNESYVDTAAM------------EAERLHVSATLACLTAIIQMGLGFM 190
             ++ +   ++A +   V   +                 + V +T+  +  + Q+ +GF 
Sbjct: 180 LQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRICDKSCYAIMVGSTVTFIAGVYQVAMGFF 239

Query: 191 QFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPH 250
           Q GFV++YLS++ + GF+T A   IL S  KY+ GL +P   G GS++ T+I + +N+  
Sbjct: 240 QVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTWIHVFRNIHK 299

Query: 251 TNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQ 310
           TN+  LI +L+    L+  KELN  +  K++ PIP E++VVV AT  S   K+ + Y+  
Sbjct: 300 TNLCDLITSLLCLLVLLPTKELNEHFKSKLKAPIPIELVVVVAATLASHFGKLHENYNSS 359

Query: 311 IVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMI 370
           I G I  GF  P  P  +    +   A +++I+ + I +++    A KHGY V +NQEM 
Sbjct: 360 IAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMY 419

Query: 371 ALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLP 430
           A+G  N   SFF       AL+ TL  +  G  +Q++ +  +LV+++ +LV+    Y L 
Sbjct: 420 AIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQ 479

Query: 431 KSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSV 490
           KSVLG +  VNL+ +L++  D   +W  S++D  IW V+ LSS  LS   G+ VGV FS+
Sbjct: 480 KSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSI 539

Query: 491 LVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKV 550
             V+ +TQ      L  V +++++ +   Y   Q   GIKI  + +PLY+ N E F+  +
Sbjct: 540 FCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSAL 599

Query: 551 IAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDP 610
             +T ++P  + +A +K  K++               +K K V+L  +Q +       DP
Sbjct: 600 YKQT-VNPILIKVAWKKAAKRK---------------IKEKVVTLGGIQDEMSVQLSHDP 643

Query: 611 NNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMS 670
                                                            +  HT+++D S
Sbjct: 644 -------------------------------------------------LELHTIVIDCS 654

Query: 671 GVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSI 730
            + F+D  GI  L ++   Y  IG++V L   +  V + +++G   +    E   +F S+
Sbjct: 655 AIQFLDTAGIHTLKEVRRDYEAIGIQVLLAQCNPTVRDSLTNGEYCK--KEEENLLFYSV 712

Query: 731 HDAVLFAQAN 740
           ++A+ FA+ +
Sbjct: 713 YEAMAFAEVS 722


>gi|16418457 solute carrier family 26, member 8 isoform a [Homo
           sapiens]
          Length = 970

 Score =  308 bits (788), Expect = 2e-83
 Identities = 226/778 (29%), Positives = 382/778 (49%), Gaps = 74/778 (9%)

Query: 42  RCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLAN--LP 99
           RCS  +    V  + P L W+  Y++KD+++ DLL G+S G +QVPQG+  +LLA   +P
Sbjct: 63  RCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIP 122

Query: 100 AVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNA--TNE 157
            +N  Y++F   + Y   G  HQM  G+F ++S L+ N+ L+++P +  Q+   +   NE
Sbjct: 123 PLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINV-LKVSPFNNGQLVMGSFVKNE 181

Query: 158 SYVDTAAMEAER-LHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQIL 216
               +  M   + L V AT   LT IIQ+ +G +  GF+A YL ES +  ++ A  L I+
Sbjct: 182 FSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIM 241

Query: 217 ISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARY 276
           +S L +IFG+ I  + GP S  +  I+ C  LP  N  S++       FL +V  L    
Sbjct: 242 LSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSIL------VFLTVVVALRINK 295

Query: 277 MHKIRF---PI--PTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWK 331
             +I F   PI  P E+ +++  T I+    M  +    ++  I   F  PV+P  S   
Sbjct: 296 CIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLP 355

Query: 332 DMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCAL 391
            +I  AFSL++VS  + + +G+ +A+ H Y V+SNQ++IA+G  N   SFF+  V   A+
Sbjct: 356 KIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAI 415

Query: 392 SVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTD 451
           + T+  D +GG+ Q ASL  + V+++ M+ +G + Y LP +VL  +I  N+   L+ +++
Sbjct: 416 ARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISN 475

Query: 452 PYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDT 511
              LWR+ + DC +W+++F SS FL L  G+ + V  +  +   ++       L Q+ +T
Sbjct: 476 LPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNT 535

Query: 512 DIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLK- 570
           +IY +   Y     I G+KI   CS + F N    + K++ +  +D  KV L +++    
Sbjct: 536 NIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKE--VDMVKVPLKEEEIFSL 593

Query: 571 --------------------------------KQEKRRMRPTQQRRSLFMKTKTVSLQEL 598
                                           ++ + ++ P     +L   +   S+   
Sbjct: 594 FNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTS 653

Query: 599 QQDFENAPPTDPNNNQTPANGTSVSYI--TFSPDSSSPAQSEP--PASAEAPGEPSDML- 653
           Q   E+  P   ++      G     +   + P++SS   S P  P  AE+ G  S +  
Sbjct: 654 QTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSS-RNSSPGLPDVAESQGRRSLIPY 712

Query: 654 --ASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDIS 711
             AS+ P V  HT+ILD S V +VD  G+  L ++ + +    + + +   H+ +     
Sbjct: 713 SDASLLPSV--HTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFE 770

Query: 712 HGGVFEDGSLECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIR 769
               F+ G  + + +F S+HDAVLFA +           +   G +ELS+ +SE  IR
Sbjct: 771 RNDFFDAGITKTQ-LFLSVHDAVLFALS-----------RKVIGSSELSIDESETVIR 816


>gi|47131207 solute carrier family 26, member 1 isoform a [Homo
           sapiens]
          Length = 701

 Score =  302 bits (773), Expect = 1e-81
 Identities = 166/525 (31%), Positives = 291/525 (55%), Gaps = 10/525 (1%)

Query: 43  CSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVN 102
           CS   ++A+V  LLP   WL +Y+ ++Y+  D++ GL  G I VPQ +A++LLA L  + 
Sbjct: 41  CSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIY 100

Query: 103 GLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNIC---LQLA--PESKFQVFNNATNE 157
            LY+SFF  L YF +G    +  G F+++ ++VG +    LQLA    S+  +   A + 
Sbjct: 101 SLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSS 160

Query: 158 SYVDTAAM-----EAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAG 212
           +   +AAM     +   + V+  L  +T + Q+ +G ++ GFV+ YLS+  + GF   A 
Sbjct: 161 TLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGAS 220

Query: 213 LQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKEL 272
           + IL S LK++ G+ IP + GPG +V T++ + +     N+  ++ + +  A L+  KEL
Sbjct: 221 VTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKEL 280

Query: 273 NARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKD 332
           + RY H++R P+PTE++V+VVAT +S   ++ K++   + G+I  GF  P  P     + 
Sbjct: 281 SDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQR 340

Query: 333 MIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALS 392
           +   A +LA+V+   ++++    A  HGY V +NQE++A+GC N   +F        AL+
Sbjct: 341 VALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALA 400

Query: 393 VTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDP 452
            +L     G ++Q++S+  + VV++ +L L    + L +SVL  +I V+L+ +L+++ D 
Sbjct: 401 KSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDL 460

Query: 453 YYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTD 512
             LWR S  D  +W  +  +   +S   G+  GV  S+L +  +TQ      LA++ DT 
Sbjct: 461 PRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTA 520

Query: 513 IYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMD 557
            Y +   +       G+++  +  PLY+AN + F Q + + TG+D
Sbjct: 521 FYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLD 565



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 36/108 (33%), Positives = 56/108 (51%), Gaps = 3/108 (2%)

Query: 640 PASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFL 699
           PA  E  G  S   A VP    FHT+++D + + F+D  G+  L  L   YG +G+ + L
Sbjct: 587 PAQGEDLGPVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLL 646

Query: 700 VNIHAQVYNDISHGGVFEDG---SLECKHVFPSIHDAVLFAQANARDV 744
                 V + +S GG   +G   + E + +F S+HDAV  A+A  R++
Sbjct: 647 ACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARARHREL 694


>gi|20336272 solute carrier family 26, member 1 isoform a [Homo
           sapiens]
          Length = 701

 Score =  302 bits (773), Expect = 1e-81
 Identities = 166/525 (31%), Positives = 291/525 (55%), Gaps = 10/525 (1%)

Query: 43  CSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVN 102
           CS   ++A+V  LLP   WL +Y+ ++Y+  D++ GL  G I VPQ +A++LLA L  + 
Sbjct: 41  CSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIY 100

Query: 103 GLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNIC---LQLA--PESKFQVFNNATNE 157
            LY+SFF  L YF +G    +  G F+++ ++VG +    LQLA    S+  +   A + 
Sbjct: 101 SLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSS 160

Query: 158 SYVDTAAM-----EAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAG 212
           +   +AAM     +   + V+  L  +T + Q+ +G ++ GFV+ YLS+  + GF   A 
Sbjct: 161 TLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGAS 220

Query: 213 LQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKEL 272
           + IL S LK++ G+ IP + GPG +V T++ + +     N+  ++ + +  A L+  KEL
Sbjct: 221 VTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKEL 280

Query: 273 NARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKD 332
           + RY H++R P+PTE++V+VVAT +S   ++ K++   + G+I  GF  P  P     + 
Sbjct: 281 SDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQR 340

Query: 333 MIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALS 392
           +   A +LA+V+   ++++    A  HGY V +NQE++A+GC N   +F        AL+
Sbjct: 341 VALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALA 400

Query: 393 VTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDP 452
            +L     G ++Q++S+  + VV++ +L L    + L +SVL  +I V+L+ +L+++ D 
Sbjct: 401 KSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDL 460

Query: 453 YYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTD 512
             LWR S  D  +W  +  +   +S   G+  GV  S+L +  +TQ      LA++ DT 
Sbjct: 461 PRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTA 520

Query: 513 IYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMD 557
            Y +   +       G+++  +  PLY+AN + F Q + + TG+D
Sbjct: 521 FYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLD 565



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 36/108 (33%), Positives = 56/108 (51%), Gaps = 3/108 (2%)

Query: 640 PASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFL 699
           PA  E  G  S   A VP    FHT+++D + + F+D  G+  L  L   YG +G+ + L
Sbjct: 587 PAQGEDLGPVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLL 646

Query: 700 VNIHAQVYNDISHGGVFEDG---SLECKHVFPSIHDAVLFAQANARDV 744
                 V + +S GG   +G   + E + +F S+HDAV  A+A  R++
Sbjct: 647 ACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARARHREL 694


>gi|16306483 solute carrier family 26, member 7 isoform a [Homo
           sapiens]
          Length = 656

 Score =  278 bits (712), Expect = 1e-74
 Identities = 153/491 (31%), Positives = 266/491 (54%), Gaps = 3/491 (0%)

Query: 56  LPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYF 115
           LP+L W P Y +K+ ++PD + G+     QV QG+AFA+L+++  V GLY S FP + Y 
Sbjct: 32  LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91

Query: 116 FLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSAT 175
             G  H +  GTFA+ S++  N   ++ P++  Q     +N S +  +  E +R+HV+A 
Sbjct: 92  IFGMGHHVATGTFALTSLISANAVERIVPQN-MQNLTTQSNTSVLGLSDFEMQRIHVAAA 150

Query: 176 LACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPG 235
           ++ L  +IQ+ +  +Q G     ++E  I    T A   ++ S +KY+ G+ +P  +GP 
Sbjct: 151 VSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPL 210

Query: 236 SIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVAT 295
              + +  + +N+    + +L+ +L+S   LVLVKELN ++  KI+  +P ++++++ A+
Sbjct: 211 GFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAAS 270

Query: 296 AISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTL 355
                  M   Y +++VG I +G P+P +P ++    +I  AF +A+V YV +LA+ +  
Sbjct: 271 FACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGS 330

Query: 356 ANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVV 415
           A K  Y +D NQE +A G SN   SFF       A+  T  +   G K+QVA L   + V
Sbjct: 331 AKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFV 390

Query: 416 MITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFF 475
           +I +  +G  LY LP  VL ++I V LK  L Q  D    W   K+D  IWV +++ +  
Sbjct: 391 LIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTIC 450

Query: 476 LSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYC 535
            +   G+  GV  ++ +V+ +       ++  + + +  V  KT   ++ +Q +KII+  
Sbjct: 451 FAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKV--KTEMDSETLQQVKIISIN 508

Query: 536 SPLYFANSEIF 546
           +PL F N++ F
Sbjct: 509 NPLVFLNAKKF 519


>gi|20336282 solute carrier family 26, member 7 isoform b [Homo
           sapiens]
          Length = 663

 Score =  278 bits (712), Expect = 1e-74
 Identities = 153/491 (31%), Positives = 266/491 (54%), Gaps = 3/491 (0%)

Query: 56  LPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYF 115
           LP+L W P Y +K+ ++PD + G+     QV QG+AFA+L+++  V GLY S FP + Y 
Sbjct: 32  LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91

Query: 116 FLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSAT 175
             G  H +  GTFA+ S++  N   ++ P++  Q     +N S +  +  E +R+HV+A 
Sbjct: 92  IFGMGHHVATGTFALTSLISANAVERIVPQN-MQNLTTQSNTSVLGLSDFEMQRIHVAAA 150

Query: 176 LACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPG 235
           ++ L  +IQ+ +  +Q G     ++E  I    T A   ++ S +KY+ G+ +P  +GP 
Sbjct: 151 VSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPL 210

Query: 236 SIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVAT 295
              + +  + +N+    + +L+ +L+S   LVLVKELN ++  KI+  +P ++++++ A+
Sbjct: 211 GFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAAS 270

Query: 296 AISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTL 355
                  M   Y +++VG I +G P+P +P ++    +I  AF +A+V YV +LA+ +  
Sbjct: 271 FACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGS 330

Query: 356 ANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVV 415
           A K  Y +D NQE +A G SN   SFF       A+  T  +   G K+QVA L   + V
Sbjct: 331 AKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFV 390

Query: 416 MITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFF 475
           +I +  +G  LY LP  VL ++I V LK  L Q  D    W   K+D  IWV +++ +  
Sbjct: 391 LIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTIC 450

Query: 476 LSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYC 535
            +   G+  GV  ++ +V+ +       ++  + + +  V  KT   ++ +Q +KII+  
Sbjct: 451 FAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKV--KTEMDSETLQQVKIISIN 508

Query: 536 SPLYFANSEIF 546
           +PL F N++ F
Sbjct: 509 NPLVFLNAKKF 519


>gi|45827804 prestin isoform d [Homo sapiens]
          Length = 335

 Score =  243 bits (619), Expect = 7e-64
 Identities = 125/320 (39%), Positives = 198/320 (61%), Gaps = 6/320 (1%)

Query: 7   RYVVDRAAYSLTLFDDEFEKKDRTYP-VGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKY 65
           RY V+R  +S  +  +    KD+    + +KL+ AF C+  KI+ +++  LP+  WLP Y
Sbjct: 15  RYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAY 74

Query: 66  KIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVP 125
           K K+Y++ DL+ G+S G +Q+PQG+AFA+LA +P + GLYSSF+P++ Y FLG    +  
Sbjct: 75  KFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISI 134

Query: 126 GTFAVISILVGNICLQLAPESKFQVFN-NATNESYVDTAAMEAERLHVSATLACLTAIIQ 184
           G FAVIS+++G + ++L P+        NATN     T A +A R+ V+ ++  L+ IIQ
Sbjct: 135 GPFAVISLMIGGVAVRLVPDDIVIPGGVNATN----GTEARDALRVKVAMSVTLLSGIIQ 190

Query: 185 MGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDI 244
             LG  +FGFVAIYL+E  +RGF TAA + +  S+LKY+FG+    Y+G  S+V++ + +
Sbjct: 191 FCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAV 250

Query: 245 CKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMP 304
            +N+ + N+ SL   L+    L+  KE N R+  K+  PIP E   VV+ T IS G  + 
Sbjct: 251 LQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLK 310

Query: 305 KKYHMQIVGEIQRGFPTPVS 324
           + Y++ +VG +  GF T ++
Sbjct: 311 ESYNVDVVGTLPLGFHTEMT 330


>gi|65506789 solute carrier family 26, member 10 [Homo sapiens]
          Length = 563

 Score =  228 bits (580), Expect = 2e-59
 Identities = 129/385 (33%), Positives = 220/385 (57%), Gaps = 7/385 (1%)

Query: 83  SIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQL 142
           S  +P GMAFALLA++P V GLY+SFFP+L Y  LG    +  GTFA++S++ G+   +L
Sbjct: 36  STSIP-GMAFALLASVPPVFGLYTSFFPVLIYSLLGTGRHLSTGTFAILSLMTGSAVERL 94

Query: 143 APESKFQVFNNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSES 202
            PE          N S ++   ++A+R+ V+A +A  +  + +G+  +Q G ++ +LSE 
Sbjct: 95  VPEPL------VGNLSGIEKEQLDAQRVGVAAAVAFGSGALMLGMFVLQLGVLSTFLSEP 148

Query: 203 FIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALIS 262
            ++   + A L +L+S L  + GL++P   G  S+  T   +   LP ++ A L  + +S
Sbjct: 149 VVKALTSGAALHVLLSQLPSLLGLSLPRQIGCFSLFKTLASLLTALPRSSPAELTISALS 208

Query: 263 GAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTP 322
            A LV VKELN R+  ++  PIP E+++V++A+ +     +  +Y +QIVG +  GFP P
Sbjct: 209 LALLVPVKELNVRFRDRLPTPIPGEVVLVLLASVLCFTSSVDTRYQVQIVGLLPGGFPQP 268

Query: 323 VSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFF 382
           + P +++   ++  +  +A+VS+ ++ ++    A+K+ Y +DSNQE +A G SN   S F
Sbjct: 269 LLPNLAELPRILADSLPIALVSFAVSASLASIHADKYSYTIDSNQEFLAHGASNLISSLF 328

Query: 383 KIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNL 442
                   L+ T  +  AGGK+Q+A L    VV+  +L LG + Y LPK+VL  +   ++
Sbjct: 329 SCFPNSATLATTNLLVDAGGKTQLAGLFSCTVVLSVLLWLGPFFYYLPKAVLACINISSM 388

Query: 443 KNSLKQLTDPYYLWRKSKLDCCIWV 467
           +    Q+ +   LW  S++D  + V
Sbjct: 389 RQVFCQMQELPQLWHISRVDFLLQV 413



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 19/77 (24%), Positives = 38/77 (49%), Gaps = 6/77 (7%)

Query: 665 LILDMSGVSFVDLMG----IKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGS 720
           ++LD SGV+F D  G    ++   +L+S      +++ L   +A V   ++  G+ +   
Sbjct: 467 VVLDFSGVTFADAAGAREVVQVRERLASRCRDARIRLLLAQCNALVQGTLTRVGLLD--R 524

Query: 721 LECKHVFPSIHDAVLFA 737
           +    +F S+ DA  +A
Sbjct: 525 VTPDQLFVSVQDAAAYA 541


>gi|20336285 solute carrier family 26, member 8 isoform b [Homo
           sapiens]
          Length = 865

 Score =  179 bits (453), Expect = 1e-44
 Identities = 139/524 (26%), Positives = 246/524 (46%), Gaps = 57/524 (10%)

Query: 286 TEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSY 345
           T +I ++  T I+    M  +    ++  I   F  PV+P  S    +I  AFSL++VS 
Sbjct: 205 TGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSS 264

Query: 346 VINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQ 405
            + + +G+ +A+ H Y V+SNQ++IA+G  N   SFF+  V   A++ T+  D +GG+ Q
Sbjct: 265 FLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQ 324

Query: 406 VASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCI 465
            ASL  + V+++ M+ +G + Y LP +VL  +I  N+   L+ +++   LWR+ + DC +
Sbjct: 325 FASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCAL 384

Query: 466 WVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQD 525
           W+++F SS FL L  G+ + V  +  +   ++       L Q+ +T+IY +   Y     
Sbjct: 385 WMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIIT 444

Query: 526 IQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLK--------------- 570
           I G+KI   CS + F N    + K++ +  +D  KV L +++                  
Sbjct: 445 IPGVKIFQCCSSITFVNVYYLKHKLLKE--VDMVKVPLKEEEIFSLFNSSDTNLQGGKIC 502

Query: 571 ------------------KQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNN 612
                             ++ + ++ P     +L   +   S+   Q   E+  P   ++
Sbjct: 503 RCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSS 562

Query: 613 NQTPANGTSVSYI--TFSPDSSSPAQSEP--PASAEAPGEPSDML---ASVPPFVTFHTL 665
                 G     +   + P++SS   S P  P  AE+ G  S +    AS+ P V  HT+
Sbjct: 563 VSQKNQGQQYEEVEEVWLPNNSS-RNSSPGLPDVAESQGRRSLIPYSDASLLPSV--HTI 619

Query: 666 ILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKH 725
           ILD S V +VD  G+  L ++ + +    + + +   H+ +         F+ G  + + 
Sbjct: 620 ILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQ- 678

Query: 726 VFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIR 769
           +F S+HDAVLFA +           +   G +ELS+ +SE  IR
Sbjct: 679 LFLSVHDAVLFALS-----------RKVIGSSELSIDESETVIR 711



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 63/192 (32%), Positives = 98/192 (51%), Gaps = 17/192 (8%)

Query: 42  RCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLAN--LP 99
           RCS  +    +  + P L W+  Y++KD+++ DLL G+S G +QVPQG+  +LLA   +P
Sbjct: 63  RCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIP 122

Query: 100 AVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNA--TNE 157
            +N  Y++F   + Y   G  HQM  G+F ++S L+ N+ L+++P +  Q+   +   NE
Sbjct: 123 PLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINV-LKVSPFNNGQLVMGSFVKNE 181

Query: 158 SYVDTAAMEAER-LHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQIL 216
               +  M   + L V AT   LT IIQ+       GF  I    S     M     Q L
Sbjct: 182 FSAPSYLMGYNKSLSVVATTTFLTGIIQI------IGFTVIANKIS-----MATETSQTL 230

Query: 217 ISVLKYIFGLTI 228
           I ++ Y F L +
Sbjct: 231 IDMIPYSFLLPV 242


>gi|85540447 solute carrier family 26, member 11 [Homo sapiens]
          Length = 606

 Score =  134 bits (336), Expect = 5e-31
 Identities = 115/470 (24%), Positives = 207/470 (44%), Gaps = 69/470 (14%)

Query: 56  LPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYF 115
           LP+L+WLP Y ++ ++  D + GLS G   +PQ +A+A +A LP   GLYS+F     YF
Sbjct: 34  LPILAWLPSYSLQ-WLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYF 92

Query: 116 FLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSAT 175
           FLG    +  G  A++S+LV            F  F+                    +  
Sbjct: 93  FLGTSRDVTLGPTAIMSLLV-----------SFYTFHEPA----------------YAVL 125

Query: 176 LACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPG 235
           LA L+  IQ+ +G ++ GF+  ++S   I+GF +AA + I    +K + GL         
Sbjct: 126 LAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFL 185

Query: 236 SIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIP---------- 285
            +  TF+ I +    T +   +  L+    L+LV +L   ++  +   +P          
Sbjct: 186 QVYHTFLRIAE----TRVGDAVLGLVC-MLLLLVLKLMRDHVPPVHPEMPPGVRLSRGLV 240

Query: 286 ------TEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVS----------- 328
                    +VV  A  ++   ++       + GE   G P    P  S           
Sbjct: 241 WAATTARNALVVSFAALVAYSFEVTGYQPFILTGETAEGLPPVRIPPFSVTTANGTISFT 300

Query: 329 -QWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVI 387
              +DM      + ++  + ++A+ +  A+++ Y +D+NQE++A+G +N  GS    + +
Sbjct: 301 EMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYPV 360

Query: 388 CCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLK 447
             +   T     +G  +    L   ++V++++  L    Y +PKS L A+I +    ++ 
Sbjct: 361 TGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIM----AVA 416

Query: 448 QLTDPYY---LWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVV 494
            L D      LWR  +LD     V+FL  F+  + YG+  G   S+L+++
Sbjct: 417 PLFDTKIFRTLWRVKRLDLLPLCVTFLLCFW-EVQYGILAGALVSLLMLL 465


>gi|20336274 solute carrier family 26, member 1 isoform b [Homo
           sapiens]
          Length = 224

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 52/160 (32%), Positives = 85/160 (53%), Gaps = 10/160 (6%)

Query: 43  CSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVN 102
           CS   ++A+V  LLP   WL +Y+ ++Y+  D++ GL  G I VPQ +A++LLA L  + 
Sbjct: 41  CSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIY 100

Query: 103 GLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNIC---LQLA--PESKFQVFNNATNE 157
            LY+SFF  L YF +G    +  G F+++ ++VG +    LQLA    S+  +   A + 
Sbjct: 101 SLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSS 160

Query: 158 SYVDTAAM-----EAERLHVSATLACLTAIIQMGLGFMQF 192
           +   +AAM     +   + V+  L  +T + Q   G   F
Sbjct: 161 TLNGSAAMLDCGRDCYAIRVATALTLMTGLYQTSWGRNSF 200


>gi|119943102 CREB binding protein isoform b [Homo sapiens]
          Length = 2404

 Score = 35.4 bits (80), Expect = 0.24
 Identities = 28/102 (27%), Positives = 45/102 (44%), Gaps = 9/102 (8%)

Query: 565  KQKYLKKQEKRRMRPTQ--QRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSV 622
            K K  ++Q + R++  Q  +RR   M T+ V  Q L       P T      TP      
Sbjct: 1809 KHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPP 1868

Query: 623  SYITFSPDSSSP------AQSEPPASAEAPGEPSDMLASVPP 658
            +    SP S SP      A+++PP +  + G+P+  + + PP
Sbjct: 1869 AQPQPSPVSMSPAGFPSVARTQPPTTV-STGKPTSQVPAPPP 1909


>gi|119943104 CREB binding protein isoform a [Homo sapiens]
          Length = 2442

 Score = 35.4 bits (80), Expect = 0.24
 Identities = 28/102 (27%), Positives = 45/102 (44%), Gaps = 9/102 (8%)

Query: 565  KQKYLKKQEKRRMRPTQ--QRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSV 622
            K K  ++Q + R++  Q  +RR   M T+ V  Q L       P T      TP      
Sbjct: 1847 KHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPP 1906

Query: 623  SYITFSPDSSSP------AQSEPPASAEAPGEPSDMLASVPP 658
            +    SP S SP      A+++PP +  + G+P+  + + PP
Sbjct: 1907 AQPQPSPVSMSPAGFPSVARTQPPTTV-STGKPTSQVPAPPP 1947


>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
            sapiens]
          Length = 1309

 Score = 33.9 bits (76), Expect = 0.69
 Identities = 30/108 (27%), Positives = 50/108 (46%), Gaps = 20/108 (18%)

Query: 558  PQKVLLAKQKYLKKQEKRRMRPTQQRR-SLFMK-TKTVSLQELQQDFEN----------A 605
            P +  +AK +  ++ ++ R R TQ RR SLF K +K  S+    + F +          +
Sbjct: 1046 PARKNVAKGRMARRSKRSRRRETQDRRKSLFKKISKQTSVLHTSRSFSSGLHHSLSSSES 1105

Query: 606  PPTDPNNNQTPANGTSV--------SYITFSPDSSSPAQSEPPASAEA 645
             P  P ++ +P+  T          +  T SP S+SP+ S P + A A
Sbjct: 1106 LPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSASPSSSSPASPAAA 1153


>gi|50054477 olfactory receptor, family 5, subfamily AS, member 1
           [Homo sapiens]
          Length = 324

 Score = 33.9 bits (76), Expect = 0.69
 Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 5/72 (6%)

Query: 362 DVDSNQEMIALGCSNFFGSFFKIHVIC--CALSVTLAVDGAGGKSQVASLCVSLVVMITM 419
           D   NQ ++   CS    S F +  I   C L   L++  +GG+S+  S C S ++ +T+
Sbjct: 191 DTQINQLLLFALCSFIQTSTFVVIFISYFCILITVLSIKSSGGRSKTFSTCASHLIAVTL 250

Query: 420 L---VLGIYLYP 428
               +L +YL P
Sbjct: 251 FYGALLFMYLQP 262


>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
            sapiens]
          Length = 1907

 Score = 33.5 bits (75), Expect = 0.90
 Identities = 21/92 (22%), Positives = 35/92 (38%), Gaps = 6/92 (6%)

Query: 564  AKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAP------PTDPNNNQTPA 617
            A + +LK +   R    ++R +  ++ K + L +     +  P      P  PN    P 
Sbjct: 1598 AHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPR 1657

Query: 618  NGTSVSYITFSPDSSSPAQSEPPASAEAPGEP 649
             G      +F P   S  +  PP + E P  P
Sbjct: 1658 RGPLSQNGSFGPSPVSGGECSPPLTVEPPVRP 1689


>gi|157743257 POU domain, class 6, transcription factor 2 [Homo
           sapiens]
          Length = 691

 Score = 33.5 bits (75), Expect = 0.90
 Identities = 21/65 (32%), Positives = 29/65 (44%), Gaps = 2/65 (3%)

Query: 593 VSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDM 652
           + LQ+ QQ  +  PP   N +  PA   + S     P   +P Q  PPAS + P  P+  
Sbjct: 184 LQLQQQQQQQQQQPPPSTNQHPQPAP-QAPSQSQQQPLQPTPPQQPPPASQQPPA-PTSQ 241

Query: 653 LASVP 657
           L   P
Sbjct: 242 LQQAP 246


>gi|226498466 T-cell immunoglobulin and mucin domain containing 4
           isoform 2 [Homo sapiens]
          Length = 350

 Score = 33.1 bits (74), Expect = 1.2
 Identities = 26/123 (21%), Positives = 49/123 (39%), Gaps = 1/123 (0%)

Query: 598 LQQDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVP 657
           L  + E   P+D  ++    +  +V   + + D++ P Q++   + +  G P  M   +P
Sbjct: 224 LTAESETVLPSDSWSSVESTSADTVLLTSKASDTAVPEQNKTTKTGQMDGIPMSMKNEMP 283

Query: 658 PFVTFHTLILDMSGVSFVDLMGIKALAKLSSTY-GKIGVKVFLVNIHAQVYNDISHGGVF 716
                  +   +  V F   +      KL  TY  +   ++  +     V ND+ HG   
Sbjct: 284 ISQLLMIIAPSLGFVLFALFVAFLLRGKLMETYCSQKHTRLDYIGDSKNVLNDVQHGRED 343

Query: 717 EDG 719
           EDG
Sbjct: 344 EDG 346


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,613,879
Number of Sequences: 37866
Number of extensions: 1425974
Number of successful extensions: 5707
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 5516
Number of HSP's gapped (non-prelim): 165
length of query: 887
length of database: 18,247,518
effective HSP length: 111
effective length of query: 776
effective length of database: 14,044,392
effective search space: 10898448192
effective search space used: 10898448192
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.