Search of human proteins with 217035154

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|217035154 RCSD domain containing 1 [Homo sapiens]
         (416 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|217035154 RCSD domain containing 1 [Homo sapiens]                  841   0.0  
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     79   1e-14
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              65   9e-11
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    60   5e-09
gi|149158690 HLA-B associated transcript-2 [Homo sapiens]              58   2e-08
gi|54124343 hypothetical protein LOC387680 [Homo sapiens]              57   3e-08
gi|154090959 hypothetical protein LOC55747 [Homo sapiens]              57   3e-08
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             57   4e-08
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       56   5e-08
gi|157738619 smoothelin-like 1 [Homo sapiens]                          56   5e-08
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)...    54   3e-07
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)...    54   3e-07
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)...    54   3e-07
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    53   6e-07
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    52   1e-06
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    52   1e-06
gi|150170670 piccolo isoform 2 [Homo sapiens]                          52   1e-06
gi|150378539 piccolo isoform 1 [Homo sapiens]                          52   1e-06
gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Ho...    51   2e-06
gi|46409304 glutamate-rich 1 [Homo sapiens]                            51   2e-06
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    51   2e-06
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    51   2e-06
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    51   2e-06
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    51   2e-06
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    51   2e-06
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    51   2e-06
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi...    50   3e-06
gi|239757898 PREDICTED: similar to testis expressed sequence 13A...    50   5e-06
gi|30795231 brain abundant, membrane attached signal protein 1 [...    49   6e-06
gi|239752412 PREDICTED: similar to testis expressed sequence 13A...    49   6e-06

>gi|217035154 RCSD domain containing 1 [Homo sapiens]
          Length = 416

 Score =  841 bits (2172), Expect = 0.0
 Identities = 416/416 (100%), Positives = 416/416 (100%)

Query: 1   MEERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDL 60
           MEERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDL
Sbjct: 1   MEERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDL 60

Query: 61  GQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHS 120
           GQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHS
Sbjct: 61  GQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHS 120

Query: 121 PPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSD 180
           PPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSD
Sbjct: 121 PPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSD 180

Query: 181 CGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLR 240
           CGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLR
Sbjct: 181 CGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLR 240

Query: 241 RSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPR 300
           RSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPR
Sbjct: 241 RSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPR 300

Query: 301 EEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGD 360
           EEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGD
Sbjct: 301 EEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGD 360

Query: 361 VPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQDTKM 416
           VPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQDTKM
Sbjct: 361 VPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQDTKM 416


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 100/437 (22%), Positives = 158/437 (36%), Gaps = 47/437 (10%)

Query: 7   ETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEE 66
           E     + + SP   + A   +E  +  KE  A  P   K P        K +     E 
Sbjct: 493 EAEGGEEETKSPPAEEAASPEKEAKSPVKEE-AKSPAEAKSP-------EKEEAKSPAEV 544

Query: 67  KSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFH--SPPST 124
           KSP  A  P K + KS P  +  +      PA +      KSP  +   SP    SP   
Sbjct: 545 KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKA 604

Query: 125 PS-------SPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRS 177
            S       SP     P + E    +  + PE +  P   K   +   K + P +   +S
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP--TKEEAKSPEKAKSPEKEEAKS 662

Query: 178 QSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAP-----------GSPLSSEGAAGE 226
                     +A   S +        +   P K+K+P            SP+  E  + E
Sbjct: 663 PEKA--KSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720

Query: 227 GVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARR-SSEEVDGQHPAQEEV---- 281
             ++  P ++       +++  +EE ++ E+AK+ EKA+    +  + + PA+EE     
Sbjct: 721 KAKS--PVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA 778

Query: 282 ---PE---SPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQE 335
              PE   SP     ++  +  SP +E     E E+ K  EVK    + E+       + 
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP 838

Query: 336 TKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSE 395
            KK EE  A            K  + PK+E  K K +E    EP               E
Sbjct: 839 PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKK--EPAVEKPKESKVEAKKEE 896

Query: 396 VQSEPAVPKPEDDTPVQ 412
            + +  VP PE + P +
Sbjct: 897 AEDKKKVPTPEKEAPAK 913



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 87/399 (21%), Positives = 148/399 (37%), Gaps = 35/399 (8%)

Query: 28  REQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIE 87
           +E+A +  E  +      K P  +   P K       E KSP  A  P K + KS    E
Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKS-PEKAKSPTKEEAKSPEKAKSPEKEEAKSP---E 664

Query: 88  KLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFD-Q 146
           K ++ +  +  +     SP     K       SP    S     ++  E  + PV  + +
Sbjct: 665 KAKSPVKAEAKSPEKAKSPVKAEAK-------SPEKAKSPVKEEAKSPEKAKSPVKEEAK 717

Query: 147 PPEGSHLPCYNKVRT----RGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEED 202
            PE +  P   + +T    +  +K    S    +S      L D ++ E+      +   
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL-DVKSPEAKTPAKEEARS 776

Query: 203 GDEVLPSKSKAPGSPLSSEGAAGEGVRT-LGPAEKPPLRRSPSRTEKQ---EEDRATEEA 258
             +  P K+K   SP+  E  + E  ++ L    K P +  P + E +   +E+   +E 
Sbjct: 777 PADKFPEKAK---SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEV 833

Query: 259 KNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVK 318
           K  E  +++ EE     P  EE  +S +   P+ E       E+K    E   E   E K
Sbjct: 834 KVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK 893

Query: 319 GERVQNEEVGPEHD---------SQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKE 369
            E  ++++  P  +          ++ K  E+    K+ P             K+E   E
Sbjct: 894 KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPE 953

Query: 370 KQ--QEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPE 406
           K+  +E    +P   P+T     E    +  EP+ PK E
Sbjct: 954 KKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAE 992



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 68/354 (19%), Positives = 127/354 (35%), Gaps = 16/354 (4%)

Query: 5    PAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNG 64
            P +  A     A   V   A    +  +  KE   S    + P       P K       
Sbjct: 669  PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728

Query: 65   EEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPST 124
            E K+P  A  P K + KS    +  +   T D    +     K+P  +   SP    P  
Sbjct: 729  EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD----VKSPEAKTPAKEEARSPADKFPEK 784

Query: 125  PSSPGVRS-RPSEAEEVPVSFDQPPEGSHLPCYNKVRT-------RGSIKRRPPSRRFRR 176
              SP     +  E  + P+  D       +P   +V++          +K + P ++   
Sbjct: 785  AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE 844

Query: 177  SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEK 236
             ++      + +     ++   KE    +V   K  A   P  S+  A +          
Sbjct: 845  EKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP 904

Query: 237  PPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQ--EEVPESPQTSGPEAEN 294
             P + +P++ E +E+ +  E+ +  +K    ++  +   PA+  E  PE   T   +A+ 
Sbjct: 905  TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKK 964

Query: 295  RCGSPREEKPAGEEAE--MEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVK 346
                P+ E  A E+ +   ++ ++ K E+ +      + DS+  +K  E  A K
Sbjct: 965  PEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 75/300 (25%), Positives = 118/300 (39%), Gaps = 28/300 (9%)

Query: 136 EAEEVPVSFD----QPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVE 191
           E EE  + F       PEG  LP    V T   +K     +   +S+ +   + + +  E
Sbjct: 407 EGEECRIGFGPIPFSLPEG--LPKIPSVSTHIKVKSEEKIKVVEKSEKET-VIVEEQTEE 463

Query: 192 SSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEE 251
           +       EE+  E    + K        E   GE      PAE+       +++  +EE
Sbjct: 464 TQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEE 523

Query: 252 DRATEEAKNGEKAR-RSSEEV----DGQHPAQEEVPESPQTSGPEAENRCGSPREEK--- 303
            ++  EAK+ EK   +S  EV      + PA+EE    P+   PE E    SP E K   
Sbjct: 524 AKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKE-EAKSPAEVKSPE 582

Query: 304 ----PAGEEAEM---EKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGV 356
               PA EEA+     K+ E     V+ E   P       K+  +  A  ++P       
Sbjct: 583 KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPT 642

Query: 357 K-GGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQL--ETSSEVQSEPAVPKPEDDTPVQD 413
           K     P++ K  EK +E    E   SP    A+   +  S V++E   P+ +  +PV++
Sbjct: 643 KEEAKSPEKAKSPEK-EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPE-KAKSPVKE 700



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 59/270 (21%), Positives = 93/270 (34%), Gaps = 32/270 (11%)

Query: 24   AGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPK-FKVKS 82
            A +F E+A +  +     P + K P       P+ ++ +  E KSP      P+  KVK 
Sbjct: 778  ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837

Query: 83   SPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPV 142
             P  +K +     + A   P    K    K       +P      P V  +   A E P 
Sbjct: 838  PP--KKAEE----EKAPATPKTEEKKDSKKE-----EAPKKEAPKPKVEEKKEPAVEKPK 886

Query: 143  SFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEED 202
              +   E       +K +     K  P     +             A    +   AK+E 
Sbjct: 887  --ESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED-----------AKPKEKTEVAKKEP 933

Query: 203  GDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDR--ATEEAK- 259
             D    +K+K P  P   + AA E   T     K P  +  +  + +E+D+  + E +K 
Sbjct: 934  DD----AKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP 989

Query: 260  NGEKARRSSEEVDGQHPAQEEVPESPQTSG 289
              EKA +SS          E+  E     G
Sbjct: 990  KAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 62/235 (26%), Positives = 97/235 (41%), Gaps = 17/235 (7%)

Query: 190  VESSQQNGAKEEDGDEVLPSKSKAPGSPLS----SEGAAGEGVRTLGPA--EKPPLRRSP 243
            VE+ +  G  +E  +E  P        P S    ++   GE  +T G A  E   +    
Sbjct: 2000 VEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPE 2059

Query: 244  SRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRC------G 297
            +  E QE +   +EA+   +A   SE+VD Q    E  PES     PEAE          
Sbjct: 2060 AEEEAQEAEGEVQEAEG--EAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117

Query: 298  SPREEKPAGEEAEMEKATEVKGE-RVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGV 356
            +P  E  A  E+E  +A E +GE + ++E V  +    E +   EG   +E        +
Sbjct: 2118 APETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPEL 2177

Query: 357  KGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPED-DTP 410
            +G + P+ E   + + EG +  P    +  P      +    E A P+PE  +TP
Sbjct: 2178 EGVEAPEAEGEAQPESEG-IEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETP 2231



 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 73/319 (22%), Positives = 108/319 (33%), Gaps = 57/319 (17%)

Query: 104  ASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPC----YNKV 159
            A P+S G++A           P S G  ++  E E      D  PE   +          
Sbjct: 2016 AQPESDGVEAQ----------PKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQ 2065

Query: 160  RTRGSIKR-----RPPSRRFRRSQSDCGELGDFRAVESSQQNG-AKEEDGDEVLPSKSKA 213
               G ++       P S      +++     +   VE+ +  G A++ +G E   ++ +A
Sbjct: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA 2125

Query: 214  PGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDG 273
                   E    EG       E   +    +  E Q E    E  +  E+A+   E V+ 
Sbjct: 2126 QPESEGIEAPEAEGE---AQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182

Query: 274  QHPAQEEVPESPQTSGPEAENRC-------GSPREEKPAGEEAEMEKATEVKGE------ 320
                 E  PES     PEAE           +P  E+ A  E E  +  E +GE      
Sbjct: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESE 2242

Query: 321  -RVQNEEVGPEH----DSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGA 375
               Q E+ G       D Q  +  E  + V E   +PP    GGD P Q  G        
Sbjct: 2243 GETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPS-PGGDTPHQRPGS------- 2294

Query: 376  VLEPGCSPQTGPAQLETSS 394
                    QTGP+    SS
Sbjct: 2295 --------QTGPSSSRASS 2305



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 62/238 (26%), Positives = 88/238 (36%), Gaps = 11/238 (4%)

Query: 179  SDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPG--SPLSSEGAAGEGVRTLGPAEK 236
            S+ GE G   +       G     GD+       A G  +P +   A  E      P  +
Sbjct: 1798 SERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAE 1857

Query: 237  PPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRC 296
               + +    + + ED    EA+   +A+  SE+V+      E  PES     PEAE   
Sbjct: 1858 GDAQEAEGEAQPESEDVEAPEAEG--EAQPESEDVETPEAEWEVQPESEGAEAPEAEKE- 1914

Query: 297  GSPREEKPAGEEAEMEKATEVKGERVQN-EEVGPEHDSQ---ETKKLEEGAAVKET-PHS 351
              P  E     E E E   E +G   Q  EE   E + Q   E++ +E   A +E  P S
Sbjct: 1915 AQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPES 1974

Query: 352  PPGGVKGGDVPKQEKGKEKQQEGAVLE-PGCSPQTGPAQLETSSEVQSEPAVPKPEDD 408
                    +V  QE   E Q E   +E P    +   A+ E   E     A PK E +
Sbjct: 1975 EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGE 2032



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 46/172 (26%), Positives = 70/172 (40%), Gaps = 17/172 (9%)

Query: 246  TEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSG--PEAENRCGSPREEK 303
            T + E +R +EE +      + +E    +    EE  E  +  G   EA     +  EE 
Sbjct: 1271 TNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEG 1330

Query: 304  PAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKK--LEEGAAVKETPHSPPGGVKGGDV 361
               E  ++E+  E +GE  Q EE   E   +   +   EEG  ++E    P GG++G   
Sbjct: 1331 LQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQG--- 1387

Query: 362  PKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQD 413
                   E  +EG  L+    P+ G    +  SE  S       EDD PVQ+
Sbjct: 1388 -------EALEEG--LKEEGLPEEGSVHGQELSEASSPDGKGSQEDD-PVQE 1429



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 64/251 (25%), Positives = 90/251 (35%), Gaps = 57/251 (22%)

Query: 208  PSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRAT--EEAKNGEKAR 265
            P  S+ PG     EG  GEG + L   + P L  +      QE +  T   E   G +  
Sbjct: 1732 PGLSQGPGV---DEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELG 1788

Query: 266  RSSEEVDG---------------------------QHPAQE------EVPES-----PQT 287
             + +E +G                           Q P Q       E PE+     P++
Sbjct: 1789 EAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPES 1848

Query: 288  SGPEAENRCGSPRE-EKPAGEEAEMEKATEVKGERVQNE----------EVGPEHDSQET 336
             G EA    G  +E E  A  E+E  +A E +GE               EV PE +  E 
Sbjct: 1849 EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEA 1908

Query: 337  KKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEV 396
             + E+  A  ET        +G D P+ E  + ++ E A  E     QT P      S+ 
Sbjct: 1909 PEAEK-EAQPETESVEALETEGEDEPESEGAEAQEAEEAAQE--AEGQTQPESEVIESQE 1965

Query: 397  QSEPAVPKPED 407
              E A P+ ED
Sbjct: 1966 AEEEAQPESED 1976



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 76/322 (23%), Positives = 117/322 (36%), Gaps = 41/322 (12%)

Query: 125  PSSPGVRSRPSEAEEVPVSFD----------QPPEGSHLPCYNKVRTRGSIKRRPPSRRF 174
            P S  + S+ +E E  P S D          Q  EG   P    V    +      +   
Sbjct: 1956 PESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEE 2015

Query: 175  RRSQSDCGELGDFRAVESSQQ-NGAKEEDGDEVLPSKS--KAPGSPLSSEGAAGEGVRTL 231
             + +SD  E       E +Q+  G  ++   +  P     +AP +   ++ A GE     
Sbjct: 2016 AQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAE 2075

Query: 232  GPA--EKPPLRRSPSRTEKQEEDRATEEAKNGEKARRS----SEEVDGQ-HPAQE--EVP 282
            G A  E   +    +  E Q E    E  +   +A+++    + E +G+  P  E  E P
Sbjct: 2076 GEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAP 2135

Query: 283  ESPQTSGPEAE-------NRCGSPREEKPAGEEAEMEKATEVKGERVQNE--EVGPEHDS 333
            E+   + PE+E            P  E    +EAE E   E++G        E  PE + 
Sbjct: 2136 EAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEG 2195

Query: 334  QETKKLE-------EGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVL-EPGCSPQT 385
             E  + E       EG    E         +G + P+ E   + + EG    E   SPQ 
Sbjct: 2196 IEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQV 2255

Query: 386  GPAQLETSSEVQSEPAVPKPED 407
                 +  SE  SE + P PED
Sbjct: 2256 SLG--DGQSEEASESSSPVPED 2275



 Score = 38.5 bits (88), Expect = 0.011
 Identities = 56/240 (23%), Positives = 83/240 (34%), Gaps = 48/240 (20%)

Query: 175  RRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPA 234
            +R  S CG  G      +    G+ +E   +  P+ S  P S  S   +A +G  + G +
Sbjct: 864  QRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLS 923

Query: 235  EKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAEN 294
            E                          EK  RS     GQ  A    P S   S PEA  
Sbjct: 924  E--------------------------EKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVV 957

Query: 295  RCGSPR-EEKPAGEEAEM-EKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSP 352
            R       E+P     E+ ++ T   G  ++  EV P  D       E   A +++    
Sbjct: 958  REWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGD 1017

Query: 353  PGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQ 412
            P             G++ + EGA+L    S  TGP     S E   + A P+   + P +
Sbjct: 1018 P-------------GQDPEPEGALLG---SSDTGP----QSGEGVPQGAAPEGVSEAPAE 1057


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 51/188 (27%), Positives = 78/188 (41%), Gaps = 2/188 (1%)

Query: 194 QQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDR 253
           ++N   EE G+E      +  G     E   GEG +  G  E+    R     E+++E+R
Sbjct: 722 ERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEG-KEEGEGEEVEGEREKEEGERKKEER 780

Query: 254 ATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGE-EAEME 312
           A +E K  E+  +   E +      EE  E  +  G E E   G   EE+  GE E E  
Sbjct: 781 AGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG 840

Query: 313 KATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQ 372
           +  E +GE  + E  G   +  E  + EE     E       G   G+   + +G+E++ 
Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 900

Query: 373 EGAVLEPG 380
           EG   E G
Sbjct: 901 EGEGEEEG 908



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 52/194 (26%), Positives = 76/194 (39%), Gaps = 12/194 (6%)

Query: 191  ESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQE 250
            E   + G  EE+G+E      +  G     E   GEG    G  E           E++ 
Sbjct: 859  EEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGE-EEEG 917

Query: 251  EDRATEEAKNGEKARRSSE-EVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEA 309
            E +  EE + GE      E E +G+    E   E  +  G E E       E +  GEE 
Sbjct: 918  EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977

Query: 310  EMEKATEVKGERVQNEEVGPEHDSQETKKLEEG---------AAVKETPHSPPGGVKGGD 360
            E E   E +GE    EE G E   +E +  EEG           V+       G  +G +
Sbjct: 978  EGE-GEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEE 1036

Query: 361  VPKQEKGKEKQQEG 374
               +E+G+E+++EG
Sbjct: 1037 EEGEEEGEEREKEG 1050



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 59/230 (25%), Positives = 85/230 (36%), Gaps = 32/230 (13%)

Query: 183 ELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAA-------------GEGVR 229
           E GD    E  +  G +E +G+EV   + K  G     E A              GE   
Sbjct: 741 EEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEE 800

Query: 230 TLGPAEKPPL----------RRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQE 279
           T G  E+                  R E++EE    EE   GE+     EE +G+   +E
Sbjct: 801 TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE 860

Query: 280 EVPESP--------QTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEH 331
           E  E          +  G E E       E +  GEE E E   E +GE    EE G   
Sbjct: 861 EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGK 920

Query: 332 DSQETKKLE-EGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPG 380
             +E ++ E EG   +       G  +G +   + +G+E++ EG   E G
Sbjct: 921 GEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG 970



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 51/217 (23%), Positives = 84/217 (38%), Gaps = 16/217 (7%)

Query: 179 SDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPP 238
           +D  E+ + +A    +     E  GD      S         E   GE  +  G  E+P 
Sbjct: 631 TDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERP- 689

Query: 239 LRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGS 298
                   EK+  ++   + ++GE+  +   E   Q    +E+ E  +    E E   G 
Sbjct: 690 -----GEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGD 744

Query: 299 PREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKG 358
             EE    EE E E   E +GE V+      E + +E ++ +E  A KE      G    
Sbjct: 745 REEE----EEKEGEGKEEGEGEEVEG-----EREKEEGERKKEERAGKEEKGEEEGDQGE 795

Query: 359 GDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSE 395
           G+  + E   E+++EG  +E G   + G  + E   E
Sbjct: 796 GEEEETEGRGEEKEEGGEVEGG-EVEEGKGEREEEEE 831



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 46/193 (23%), Positives = 75/193 (38%), Gaps = 20/193 (10%)

Query: 182  GELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRR 241
            GE G+    E   +   +EE+G+     + +  G     EG   EG    G  E+     
Sbjct: 941  GEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE---GEGEEE---- 993

Query: 242  SPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPRE 301
                 E+ EE+   EE   GE       EV+G+   +E   E  +  G E     G  RE
Sbjct: 994  --EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEE----GEERE 1047

Query: 302  EKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDV 361
            ++  GEE    +  E + E    E    E++ Q+ ++ ++ + +K       G VK G  
Sbjct: 1048 KEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIK-------GSVKYGKH 1100

Query: 362  PKQEKGKEKQQEG 374
               +K      +G
Sbjct: 1101 KTYQKKSVTNTQG 1113


>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
          Length = 2157

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 101/425 (23%), Positives = 156/425 (36%), Gaps = 64/425 (15%)

Query: 29  EQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQN-GEEKSPPNA---------SHPPKF 78
           E    +KE P  +P    PP + P  P     G   G  + PP+          S PP+F
Sbjct: 590 EPQLPSKEGP--EPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRF 647

Query: 79  KVKSSPLIEKLQANLTFD-------PAALLPGASPKSPGLKAMVSPFHSPPSTPSS--PG 129
           + +    + K Q    +        P   +P + P+   L A+ +P  +PP  P +  PG
Sbjct: 648 QRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAP-QAPPPPPKALYPG 706

Query: 130 VRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRA 189
              RP      P++FD  P    +P Y   R    ++ RPP   +       G +     
Sbjct: 707 ALGRPPPMP--PMNFD--PRWMMIPPYVDPRL---LQGRPPLDFYPPGVHPSGLVPR--- 756

Query: 190 VESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEG-VRTLGPAEKPPLRRSPSRTEK 248
            E S   G+  E  D   P+  +  G+P      A  G V T  PAE  PL  SP R   
Sbjct: 757 -ERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLT-SPLRQAA 814

Query: 249 QEEDRATEE-------------AKNGEKARRSSEEVDGQHPAQEEVPES---PQTSGPEA 292
            E+D+                 +  G     +      + P +E  P     P  S   A
Sbjct: 815 DEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPLEEPGPRPLPWPPGSDEVA 874

Query: 293 ENRCGSPREEKPAGEEAEM--EKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPH 350
           + +   P++E P  E A++   +A       V +   GP    +E++         ET  
Sbjct: 875 KIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPPPPRRESR--------TETRW 926

Query: 351 SPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTP 410
            P  G     +P +E G   ++ G + +P   P T   +L      Q +   PKP    P
Sbjct: 927 GPRPGSSRRGIPPEEPGAPPRRAGPIKKP--PPPTKVEELPPKPLEQGD-ETPKPPKPDP 983

Query: 411 VQDTK 415
           ++ TK
Sbjct: 984 LKITK 988



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 77/346 (22%), Positives = 103/346 (29%), Gaps = 47/346 (13%)

Query: 96  DP-AALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLP 154
           DP   L P   P+ P  + M+ PF  PP  P        P    + P  +  P   S  P
Sbjct: 230 DPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFP------PPYGPQGPYRYPTPDGPSRFP 283

Query: 155 CYNKVRTRGSIKR--RPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEE-DGDEVLPSKS 211
                R  G   R   P  R     + +  E             GA EE D  E L    
Sbjct: 284 RVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSD 343

Query: 212 KAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEV 271
           +  G     EGA G         E+ P      +      +  T +    E +R    E 
Sbjct: 344 EEDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETE- 402

Query: 272 DGQHPAQEEVPESPQTSGP--------EAENRCG------SPREEKPAGEEAEMEKATEV 317
               P   + P  P   GP        +  +R G      +P +E  A  +   + ++E+
Sbjct: 403 --PGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEI 460

Query: 318 K--GERVQNEEVGPEHDSQE---------TKKLEE--GAAVKETPHSPPGGVKGGDVPKQ 364
               ER +      E   QE          K+L+E  GA  K     P         P  
Sbjct: 461 SLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAP 520

Query: 365 EKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTP 410
                K       E    P   PA   T      EPA   P   TP
Sbjct: 521 PPAVPK-------ELPAPPAPPPASAPTPETEPEEPAQAPPAQSTP 559



 Score = 29.3 bits (64), Expect = 6.9
 Identities = 39/169 (23%), Positives = 66/169 (39%), Gaps = 14/169 (8%)

Query: 198  AKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEE 257
            +KE   ++++P     P SP++  G+ G     +   E+P  RR     ++ +  R    
Sbjct: 1205 SKEPLKEKLIPG----PLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRL 1260

Query: 258  AKNGEKARRSSE-EVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEM-EKAT 315
             +  E A R SE +     PA    PE   T+   A      P   + A +  ++  + +
Sbjct: 1261 KQERENAARGSEGKPSLTLPASAPGPEEALTTVTVA------PAPRRAAAKSPDLSNQNS 1314

Query: 316  EVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHS--PPGGVKGGDVP 362
            +   E  +      +  S+     E    V  TP +   PGG  GG VP
Sbjct: 1315 DQANEEWETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVP 1363


>gi|54124343 hypothetical protein LOC387680 [Homo sapiens]
          Length = 1341

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 58/185 (31%), Positives = 82/185 (44%), Gaps = 11/185 (5%)

Query: 67   KSPPNASHPPKFKVKS-SPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPST- 124
            ++P ++S    FK K  S  I K+QANL  +PAALLP A+ +   +K ++     P S  
Sbjct: 934  ETPQDSSGLAPFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEH 993

Query: 125  PSSPGVRSRP--SEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRR----SQ 178
              S G+ S P    + E  VSFD P +   L   NK R +   KRRP +R  RR      
Sbjct: 994  RRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGKRRPQTRAARRLAAQES 1053

Query: 179  SDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPP 238
            S+  ++   R   +   +GA   +G    P    A G   + E  A       G    P 
Sbjct: 1054 SETEDMSVPRGPIAQWADGAISPNGHR--PQLRAASGEDSTEEALAAAAAPWEG-GPVPG 1110

Query: 239  LRRSP 243
            + RSP
Sbjct: 1111 VDRSP 1115


>gi|154090959 hypothetical protein LOC55747 [Homo sapiens]
          Length = 1253

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 58/185 (31%), Positives = 82/185 (44%), Gaps = 11/185 (5%)

Query: 67   KSPPNASHPPKFKVKS-SPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPST- 124
            ++P ++S    FK K  S  I K+QANL  +PAALLP A+ +   +K ++     P S  
Sbjct: 846  ETPQDSSGLAPFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEH 905

Query: 125  PSSPGVRSRP--SEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRR----SQ 178
              S G+ S P    + E  VSFD P +   L   NK R +   KRRP +R  RR      
Sbjct: 906  RRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGKRRPQTRAARRLAAQES 965

Query: 179  SDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPP 238
            S+  ++   R   +   +GA   +G    P    A G   + E  A       G    P 
Sbjct: 966  SETEDMSVPRGPIAQWADGAISPNGHR--PQLRAASGEDSTEEALAAAAAPWEG-GPVPG 1022

Query: 239  LRRSP 243
            + RSP
Sbjct: 1023 VDRSP 1027


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 102/426 (23%), Positives = 159/426 (37%), Gaps = 62/426 (14%)

Query: 5    PAETNANVDNSASPSV-----AQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVD 59
            PA T A V  S S  V     A ++      A+    T A+  T    P S P   P + 
Sbjct: 1786 PASTLAPVLASTSAPVPASPLAPVSASASVSASVPASTSAAAITSSSAPASAPAPTPIL- 1844

Query: 60   LGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANL--TFDPAALLPGASPKSPGLKAMVSP 117
                       + S P    + +S  I  L + L  T  P      +SP +P + A   P
Sbjct: 1845 ----------ASVSTPASVTILASASIPILASALASTSAPTPAPAASSPAAPVITAPTIP 1894

Query: 118  FHSPP-STPSSPGVRSRPSEAEEVPVSFDQPPEGS--------HLPCYNKVRTRG-SIKR 167
              +P  S P +P   S P+ A   PVS   P   +        H P  N ++T   S K+
Sbjct: 1895 ASAPTASVPLAPASASAPAPAP-TPVSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQ 1953

Query: 168  RPPSRRFRRSQSDCGE--LGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAG 225
             PPS R   +Q+  G   +   +++++ Q +G    +    L     AP + L+      
Sbjct: 1954 PPPSIRLPSAQTPNGTDYVASGKSIQTPQSHGTLTAE----LWDNKVAPPAVLNDIS--- 2006

Query: 226  EGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESP 285
               + LGP   PP   S S   K      +  +  G K        +GQ    E   ++ 
Sbjct: 2007 ---KKLGPI-SPPQPPSVSAWNKPLTSFGSAPSSEGAK--------NGQESGLEIGTDTI 2054

Query: 286  QTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAV 345
            Q   P +    G+  E  P   E   +K  E K +R +    GP     + +KL + + V
Sbjct: 2055 QFGAPASN---GNENEVVPVLSEKSADKIPEPKEQRQKQPRAGP----IKAQKLPDLSPV 2107

Query: 346  KETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKP 405
            +   H  PG +      K  K K+ QQ    +EP    +  PA + ++  V ++      
Sbjct: 2108 ENKEHK-PGPIGKERSLKNRKVKDAQQ----VEPEGQEKPSPATVRSTDPVTTKETKAVS 2162

Query: 406  EDDTPV 411
            E  T +
Sbjct: 2163 EMSTEI 2168



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 42/176 (23%), Positives = 74/176 (42%), Gaps = 23/176 (13%)

Query: 240 RRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPE------------SPQT 287
           +R   +  KQE+++  E  K  EK  +  +E + +   ++E  +             P  
Sbjct: 552 QREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMV 611

Query: 288 SGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKE 347
              E+EN C   +EE+P     +  ++ +     V   E  PE  SQ    +  G   + 
Sbjct: 612 EKQESENSCN--KEEEPVFTRQDSNRSEKEATPVVHETE--PESGSQPRPAVLSGYFKQF 667

Query: 348 TPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVP 403
               PP   +  +  KQ++ +++QQ+G +      PQT P+Q  +SS V   P  P
Sbjct: 668 QKSLPPRFQRQQEQMKQQQWQQQQQQGVL------PQTVPSQ-PSSSTVPPPPHRP 716



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 76/318 (23%), Positives = 120/318 (37%), Gaps = 53/318 (16%)

Query: 115 VSPFHSPPSTPSSPGVRS-----RPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRP 169
           VS   S    P+ P V        PS  +E   S   PP    L   +    R ++  RP
Sbjct: 370 VSNTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRP 429

Query: 170 PSRRFRRSQSDCGELGDFRAVESSQQNGAKE------EDGDEVLPSKSKAPGSPLSSEGA 223
                ++  +D  E+   R  + S+ + A E      E+ +  +  + KA         A
Sbjct: 430 GPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKA---------A 480

Query: 224 AGEGVRTL----GPAEKPPLRRSPSRTEKQEE-DRATEEAKNGEKARRSSEEVDGQHPAQ 278
             E ++ L    G  EK P        E+++E +R  E  K  E+ R    E D +   +
Sbjct: 481 CAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQE 540

Query: 279 EEVP-ESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETK 337
           +E   E  Q    E E      ++EK    E + EK  E++  + Q +E   E   +E +
Sbjct: 541 KEKELEKEQEKQREMEKE---RKQEKEKELERQKEKEKELQKMKEQEKECELE---KERE 594

Query: 338 KLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPA---QLETSS 394
           KLEE    +E              P  E   EKQ+     E  C+ +  P    Q    S
Sbjct: 595 KLEEKIEPRE--------------PNLEPMVEKQES----ENSCNKEEEPVFTRQDSNRS 636

Query: 395 EVQSEPAVPKPEDDTPVQ 412
           E ++ P V + E ++  Q
Sbjct: 637 EKEATPVVHETEPESGSQ 654



 Score = 37.0 bits (84), Expect = 0.033
 Identities = 51/198 (25%), Positives = 77/198 (38%), Gaps = 22/198 (11%)

Query: 204  DEVLPSKSKAPGSPLSSEGAAGE----GVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAK 259
            ++V  SKS+    P  S     E     VR  GP +KP LR         +E+R   + K
Sbjct: 982  EKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLR-------DMKEEREQRKEK 1034

Query: 260  NGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKG 319
             GEKA + +E+V  +    E+    P    P+            P   EAE   +TE   
Sbjct: 1035 EGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTET-- 1092

Query: 320  ERVQNEEVGPEHDSQETKK-LEEGAAVKETP--HSPPGGVKGGDVPKQEKGKEKQQEGAV 376
                      +  SQ+T+K LE  + V+  P   +         V K+EK  EK     +
Sbjct: 1093 ------ATLAQKPSQDTEKPLEPVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDL 1146

Query: 377  LEPGCSPQTGPAQLETSS 394
            +     P + PA  + S+
Sbjct: 1147 VIERPRPDSRPAVKKEST 1164



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 32/154 (20%), Positives = 64/154 (41%), Gaps = 9/154 (5%)

Query: 194  QQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDR 253
            Q    K EDG+   P +      P++++    +  R   PA + P R+ P+R  +Q++  
Sbjct: 1379 QSEVPKPEDGE---PPRRHEQFIPIAADKRPPKFERKFDPARERPRRQRPTRPPRQDKPP 1435

Query: 254  ATEEAKNGEKARRSSEEV------DGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGE 307
                 +  E A +S+E V         + AQE V      SG +  +       ++   E
Sbjct: 1436 RFRRLREREAASKSNEVVAVPTNGTVNNVAQEPVNTLGDISGNKTPDLSNQNSSDQANEE 1495

Query: 308  EAEMEKATEVKGERVQNEEVGPEHDSQETKKLEE 341
                 ++++    R ++E+   + ++Q   K+ E
Sbjct: 1496 WETASESSDFNERRERDEKKNADLNAQTVVKVGE 1529



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 37/181 (20%), Positives = 69/181 (38%), Gaps = 55/181 (30%)

Query: 242 SPSRTEKQEEDRATEEAKNGEKARRSSE----EVDGQHPAQEEVPESPQTSGPEAENRCG 297
           S S  E   ED+ ++ ++N E  + + E    +   Q PAQ  V + P   GP      G
Sbjct: 342 SNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPSFNQERG 401

Query: 298 S------------------------------PREEKPAGE----------EAEMEKATEV 317
           +                              P +++ A E          ++E+  A E 
Sbjct: 402 TSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVER 461

Query: 318 KGERVQNEEVGPEHD-----SQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQ 372
             +R + EE   E       +++ K+L+E   + E   SP       ++ ++E+ KE+++
Sbjct: 462 ARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPE------EIREREREKERER 515

Query: 373 E 373
           E
Sbjct: 516 E 516



 Score = 30.4 bits (67), Expect = 3.1
 Identities = 73/341 (21%), Positives = 109/341 (31%), Gaps = 62/341 (18%)

Query: 25   GRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNA----------SH 74
            G FR         P+   T R+P      + P+       E+  PP              
Sbjct: 1346 GTFRRGGRDPGGRPSRPSTLRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFIPIAADKR 1405

Query: 75   PPKFKVKSSPLIEKLQANLTFDPAALLPGAS-PKSPGLKAMVSPFHSPPSTPSSPGVRSR 133
            PPKF+ K             FDPA   P    P  P       P    P        R  
Sbjct: 1406 PPKFERK-------------FDPARERPRRQRPTRP-------PRQDKPPRFRRLREREA 1445

Query: 134  PSEAEEVPVSFDQPPEGS-HLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVES 192
             S++ EV      P  G+ +      V T G I          ++ SD        A ES
Sbjct: 1446 ASKSNEVVAV---PTNGTVNNVAQEPVNTLGDISGNKTPDLSNQNSSDQANEEWETASES 1502

Query: 193  SQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEED 252
            S  N  +E D         +   + L+++     G   L P  +   R   S + ++  D
Sbjct: 1503 SDFNERRERD---------EKKNADLNAQTVVKVGENVLPPKREIAKR---SFSSQRPVD 1550

Query: 253  RATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEME 312
            R      NG    +S     G        P + + SGP +++    P +++PAG      
Sbjct: 1551 RQNRRGNNGPP--KSGRNFSG--------PRNERRSGPPSKSGKRGPFDDQPAGTTG--- 1597

Query: 313  KATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPP 353
                + G    ++E  P    Q+  K   G   +E P   P
Sbjct: 1598 -VDLINGSSAHHQEGVPNGTGQKNSKDSTGKK-REDPKPGP 1636


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 98/395 (24%), Positives = 146/395 (36%), Gaps = 59/395 (14%)

Query: 29  EQAAAAKETPASKPTRRKPPCS--LPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLI 86
           E  A A+  PA +   +  P +   P       + +N  +  PP A        + +PL+
Sbjct: 276 EATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPA--------EEAPLV 327

Query: 87  EKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQ 146
           E         PA + P ++ +SP ++ +      PPS   SP        +EE P     
Sbjct: 328 EF--------PAEIQPPSAEESPSVELLAEIL--PPSAEESP--------SEEPPAEI-L 368

Query: 147 PPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEV 206
           PP     P    V   G I  R PS +    +           V+     GA EE   +V
Sbjct: 369 PPPAEKSP---SVELLGEI--RSPSAQKAPIE-----------VQPLPAEGALEEAPAKV 412

Query: 207 LP---SKSKAPGSPLSSEGAAGEGVRTL--GPAEKPPLRRSPSRTEKQEEDRATEEAKNG 261
            P    ++ A   PL  E A  E  R L    A + P   +P+  +       T E  + 
Sbjct: 413 EPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEEASA 472

Query: 262 E-KARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEME----KATE 316
           E +   ++E    + PA+   P S +TS  EA     SP  E+   EEA  E     A E
Sbjct: 473 EIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIE 532

Query: 317 VKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQ-EKGKEKQQEGA 375
              +    E   P   S+ET   EE  A  ++P +    ++   +  Q   G+E   E A
Sbjct: 533 APADETPAEAQSPL--SEET-SAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEA 589

Query: 376 VLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTP 410
                    T  +  E  +EVQ  PA   P +  P
Sbjct: 590 SAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQP 624



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 73/326 (22%), Positives = 111/326 (34%), Gaps = 57/326 (17%)

Query: 111 LKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVR---------- 160
           +K + S    PPST   P     P   E    +  +P E +H+                 
Sbjct: 249 VKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDAEAATA 308

Query: 161 -TRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVL-----PSKSKAP 214
               S+K +PP        ++   L +F A    Q   A+E    E+L     PS  ++P
Sbjct: 309 VAENSVKVQPPP-------AEEAPLVEFPA--EIQPPSAEESPSVELLAEILPPSAEESP 359

Query: 215 GSPLSSE-----GAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSE 269
                +E           V  LG    P  +++P   +    + A EEA           
Sbjct: 360 SEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAP---------- 409

Query: 270 EVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGP 329
               + P  EE     Q   PE      +PREE     E ++  A E   E    E   P
Sbjct: 410 -AKVEPPTVEETLADVQPLLPEE-----APREE---ARELQLSTAMETPAEEAPTEFQSP 460

Query: 330 EHDSQETKKLEEGAAVKETPHS-PPGGVKGGDV--PKQEKGKEKQQEGAVLEPGCSPQTG 386
               +ET   E  A ++    + PP      +   P  E+   ++    V  P     T 
Sbjct: 461 L--PKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTA 518

Query: 387 PAQLETSSEVQSEPAVPKPEDDTPVQ 412
               E S+E+Q   A+  P D+TP +
Sbjct: 519 E---EASAEIQLLAAIEAPADETPAE 541


>gi|157738619 smoothelin-like 1 [Homo sapiens]
          Length = 512

 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 46/201 (22%), Positives = 81/201 (40%), Gaps = 5/201 (2%)

Query: 190 VESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQ 249
           VES ++ G KE+   E+     +   + + S+   G    T    ++   + S   +EKQ
Sbjct: 96  VESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQ 155

Query: 250 EEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENR---CGSPREEKPAG 306
           + +    + ++G+KA   + + D   P      E  +T+  E   +   C +  +EK   
Sbjct: 156 KAEEKEAKPESGQKA--DANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATD 213

Query: 307 EEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEK 366
           EEA+ E    V  +  + E   P+   +     +E A  KE          G    +QE+
Sbjct: 214 EEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQ 273

Query: 367 GKEKQQEGAVLEPGCSPQTGP 387
             EK+ EG       SP+  P
Sbjct: 274 DVEKEPEGGAGVIPSSPEEWP 294



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 56/238 (23%), Positives = 86/238 (36%), Gaps = 20/238 (8%)

Query: 191 ESSQQNGAKEEDG--DEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEK 248
           ES +Q  A  EDG   E+    +      + S+  AG         +K    +  +    
Sbjct: 67  ESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGS 126

Query: 249 QEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEE 308
           QE     EE K+  K     E        + E  E+   SG +A+       E K   EE
Sbjct: 127 QEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEE 186

Query: 309 AEMEKAT-EVKGERVQNEEVGPEHDSQETKKLEEGAAV-----KETPHSPPGGVKGGDVP 362
            + + A+ E  G+R +      E  + E  K E   AV     K  P  P G  +     
Sbjct: 187 EDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGA 246

Query: 363 KQEK-GKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEP-----AVPKPEDDTPVQDT 414
           K+E   KE+ ++    EPG   +      E   +V+ EP      +P   ++ P   T
Sbjct: 247 KEEADAKEEAEDAEEAEPGSPSE------EQEQDVEKEPEGGAGVIPSSPEEWPESPT 298



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 51/226 (22%), Positives = 82/226 (36%), Gaps = 25/226 (11%)

Query: 191 ESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQE 250
           ES Q+  A + D  E   +  +      S E        +  P EK     + + ++K  
Sbjct: 165 ESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAV 224

Query: 251 -EDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEA 309
            ED A  E K  +       + + +H A+EE     +    E E   GSP EE+    E 
Sbjct: 225 VEDEAKAEPKEPD------GKEEAKHGAKEEADAKEEAEDAE-EAEPGSPSEEQEQDVEK 277

Query: 310 EMEKATEV--------------KGERVQNEEVGPE-HDSQETKKLEEGAAVKETPHSPPG 354
           E E    V              +G  +  + +GP+   S +T      ++  + P SPP 
Sbjct: 278 EPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPE 337

Query: 355 GVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEP 400
               G+  K+EK  E++        G   Q   A ++      S P
Sbjct: 338 SPSSGE--KKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGP 381


>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 54/193 (27%), Positives = 80/193 (41%), Gaps = 27/193 (13%)

Query: 205  EVLPSKSKAPG-SPLSSEGAAG------EGVRTLGPAEKPPLRRSPSRTEKQEEDRATEE 257
            E++P  ++A    P+ S   AG      E   T+ P E  PL     R E++E     EE
Sbjct: 1178 EIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEE--RKEEEEMQAEAEE 1235

Query: 258  AKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPR---------EEKPAGEE 308
            A+ GE+   +S EV    PA        +T  PE E     PR         EE+   EE
Sbjct: 1236 AEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEE 1295

Query: 309  AEMEKATEVKGERVQNEEVGPEH------DSQETKKLEEGAA---VKETPHSPPGGVKGG 359
             E E+  +   E  QN++   +       +S + K+LEE      VKE P      +   
Sbjct: 1296 PEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDAN 1355

Query: 360  DVPKQEKGKEKQQ 372
                +EK K+K++
Sbjct: 1356 MQKSREKIKDKEE 1368



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 40/252 (15%)

Query: 191  ESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPA-----EKPPLRRSPSR 245
            E  Q    + E+G+E   + S+ P +  +    + E   T  P      EKP +     +
Sbjct: 1227 EEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE-TETKEPEVEEEEEKPRVSEEQRQ 1285

Query: 246  TEKQ-----------EEDRATEEAKNGEKARRSSEEVDG-----------QHPAQEEVPE 283
            +E++           EED A E A+N +    + +E DG           + P +E+V E
Sbjct: 1286 SEEEQQELEEPEPEEEEDAAAETAQNDD--HDADDEDDGHLESTKKKELEEQPTREDVKE 1343

Query: 284  SPQTSGPEAENRCGSPREEKPAGEEAEMEKA-------TEVKGERVQNEEVGPEHDSQET 336
             P       +      RE+    EE E++         T V  E++   E   E DS   
Sbjct: 1344 EPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTK 1403

Query: 337  KKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQ-LETSSE 395
            ++L E    +E PHS         V    + +  + EGA  +  C       Q L++ ++
Sbjct: 1404 EELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQD--CEETLAACQTLQSYTQ 1461

Query: 396  VQSEPAVPKPED 407
               +P +   ED
Sbjct: 1462 ADEDPQMSMVED 1473



 Score = 32.3 bits (72), Expect = 0.81
 Identities = 48/199 (24%), Positives = 83/199 (41%), Gaps = 27/199 (13%)

Query: 180  DCGELGDF---RAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTL-GPAE 235
            +CGE  +    +  ES +Q  A EE      PS+   P  P   +    EGV    G  +
Sbjct: 901  ECGEKSEATQEQYTESEEQLVASEEQ-----PSQDGKPDLP---KRRLSEGVEPWRGQLK 952

Query: 236  KPPLRRSPSRTEKQEEDRATEEAKNGEKA--RRSSEEVDGQHPAQEEVPESPQTSGPEAE 293
            K P       TE  E  R       G++A  R  SE  +     +EE PESP++S P   
Sbjct: 953  KSPEALKCRLTEGSE--RLPRRYSEGDRAVLRGFSESSE-----EEEEPESPRSSSPPIL 1005

Query: 294  NRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPP 353
             +  + + +KP      + +   V+  +  N  V  E  S+ T+ L+E     ++    P
Sbjct: 1006 TK-PTLKRKKPF-----LHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMP 1059

Query: 354  GGVKGGDVPKQEKGKEKQQ 372
                  ++ ++E+ +++ +
Sbjct: 1060 RLEPTFEIDEEEEEEDENE 1078


>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 54/193 (27%), Positives = 80/193 (41%), Gaps = 27/193 (13%)

Query: 205  EVLPSKSKAPG-SPLSSEGAAG------EGVRTLGPAEKPPLRRSPSRTEKQEEDRATEE 257
            E++P  ++A    P+ S   AG      E   T+ P E  PL     R E++E     EE
Sbjct: 1178 EIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEE--RKEEEEMQAEAEE 1235

Query: 258  AKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPR---------EEKPAGEE 308
            A+ GE+   +S EV    PA        +T  PE E     PR         EE+   EE
Sbjct: 1236 AEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEE 1295

Query: 309  AEMEKATEVKGERVQNEEVGPEH------DSQETKKLEEGAA---VKETPHSPPGGVKGG 359
             E E+  +   E  QN++   +       +S + K+LEE      VKE P      +   
Sbjct: 1296 PEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDAN 1355

Query: 360  DVPKQEKGKEKQQ 372
                +EK K+K++
Sbjct: 1356 MQKSREKIKDKEE 1368



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 40/252 (15%)

Query: 191  ESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPA-----EKPPLRRSPSR 245
            E  Q    + E+G+E   + S+ P +  +    + E   T  P      EKP +     +
Sbjct: 1227 EEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE-TETKEPEVEEEEEKPRVSEEQRQ 1285

Query: 246  TEKQ-----------EEDRATEEAKNGEKARRSSEEVDG-----------QHPAQEEVPE 283
            +E++           EED A E A+N +    + +E DG           + P +E+V E
Sbjct: 1286 SEEEQQELEEPEPEEEEDAAAETAQNDD--HDADDEDDGHLESTKKKELEEQPTREDVKE 1343

Query: 284  SPQTSGPEAENRCGSPREEKPAGEEAEMEKA-------TEVKGERVQNEEVGPEHDSQET 336
             P       +      RE+    EE E++         T V  E++   E   E DS   
Sbjct: 1344 EPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTK 1403

Query: 337  KKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQ-LETSSE 395
            ++L E    +E PHS         V    + +  + EGA  +  C       Q L++ ++
Sbjct: 1404 EELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQD--CEETLAACQTLQSYTQ 1461

Query: 396  VQSEPAVPKPED 407
               +P +   ED
Sbjct: 1462 ADEDPQMSMVED 1473



 Score = 32.3 bits (72), Expect = 0.81
 Identities = 48/199 (24%), Positives = 83/199 (41%), Gaps = 27/199 (13%)

Query: 180  DCGELGDF---RAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTL-GPAE 235
            +CGE  +    +  ES +Q  A EE      PS+   P  P   +    EGV    G  +
Sbjct: 901  ECGEKSEATQEQYTESEEQLVASEEQ-----PSQDGKPDLP---KRRLSEGVEPWRGQLK 952

Query: 236  KPPLRRSPSRTEKQEEDRATEEAKNGEKA--RRSSEEVDGQHPAQEEVPESPQTSGPEAE 293
            K P       TE  E  R       G++A  R  SE  +     +EE PESP++S P   
Sbjct: 953  KSPEALKCRLTEGSE--RLPRRYSEGDRAVLRGFSESSE-----EEEEPESPRSSSPPIL 1005

Query: 294  NRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPP 353
             +  + + +KP      + +   V+  +  N  V  E  S+ T+ L+E     ++    P
Sbjct: 1006 TK-PTLKRKKPF-----LHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMP 1059

Query: 354  GGVKGGDVPKQEKGKEKQQ 372
                  ++ ++E+ +++ +
Sbjct: 1060 RLEPTFEIDEEEEEEDENE 1078


>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 54/193 (27%), Positives = 80/193 (41%), Gaps = 27/193 (13%)

Query: 205  EVLPSKSKAPG-SPLSSEGAAG------EGVRTLGPAEKPPLRRSPSRTEKQEEDRATEE 257
            E++P  ++A    P+ S   AG      E   T+ P E  PL     R E++E     EE
Sbjct: 1178 EIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEE--RKEEEEMQAEAEE 1235

Query: 258  AKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPR---------EEKPAGEE 308
            A+ GE+   +S EV    PA        +T  PE E     PR         EE+   EE
Sbjct: 1236 AEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEE 1295

Query: 309  AEMEKATEVKGERVQNEEVGPEH------DSQETKKLEEGAA---VKETPHSPPGGVKGG 359
             E E+  +   E  QN++   +       +S + K+LEE      VKE P      +   
Sbjct: 1296 PEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDAN 1355

Query: 360  DVPKQEKGKEKQQ 372
                +EK K+K++
Sbjct: 1356 MQKSREKIKDKEE 1368



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 40/252 (15%)

Query: 191  ESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPA-----EKPPLRRSPSR 245
            E  Q    + E+G+E   + S+ P +  +    + E   T  P      EKP +     +
Sbjct: 1227 EEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE-TETKEPEVEEEEEKPRVSEEQRQ 1285

Query: 246  TEKQ-----------EEDRATEEAKNGEKARRSSEEVDG-----------QHPAQEEVPE 283
            +E++           EED A E A+N +    + +E DG           + P +E+V E
Sbjct: 1286 SEEEQQELEEPEPEEEEDAAAETAQNDD--HDADDEDDGHLESTKKKELEEQPTREDVKE 1343

Query: 284  SPQTSGPEAENRCGSPREEKPAGEEAEMEKA-------TEVKGERVQNEEVGPEHDSQET 336
             P       +      RE+    EE E++         T V  E++   E   E DS   
Sbjct: 1344 EPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTK 1403

Query: 337  KKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQ-LETSSE 395
            ++L E    +E PHS         V    + +  + EGA  +  C       Q L++ ++
Sbjct: 1404 EELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQD--CEETLAACQTLQSYTQ 1461

Query: 396  VQSEPAVPKPED 407
               +P +   ED
Sbjct: 1462 ADEDPQMSMVED 1473



 Score = 32.3 bits (72), Expect = 0.81
 Identities = 48/199 (24%), Positives = 83/199 (41%), Gaps = 27/199 (13%)

Query: 180  DCGELGDF---RAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTL-GPAE 235
            +CGE  +    +  ES +Q  A EE      PS+   P  P   +    EGV    G  +
Sbjct: 901  ECGEKSEATQEQYTESEEQLVASEEQ-----PSQDGKPDLP---KRRLSEGVEPWRGQLK 952

Query: 236  KPPLRRSPSRTEKQEEDRATEEAKNGEKA--RRSSEEVDGQHPAQEEVPESPQTSGPEAE 293
            K P       TE  E  R       G++A  R  SE  +     +EE PESP++S P   
Sbjct: 953  KSPEALKCRLTEGSE--RLPRRYSEGDRAVLRGFSESSE-----EEEEPESPRSSSPPIL 1005

Query: 294  NRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPP 353
             +  + + +KP      + +   V+  +  N  V  E  S+ T+ L+E     ++    P
Sbjct: 1006 TK-PTLKRKKPF-----LHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMP 1059

Query: 354  GGVKGGDVPKQEKGKEKQQ 372
                  ++ ++E+ +++ +
Sbjct: 1060 RLEPTFEIDEEEEEEDENE 1078


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 85/397 (21%), Positives = 146/397 (36%), Gaps = 44/397 (11%)

Query: 42  PTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALL 101
           P RR+P  S      K D  +  E++    A      K +S P   +  A L+   A+ L
Sbjct: 402 PVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPR--ARLSASTASEL 459

Query: 102 PGASPKSPGLKAMVSP-FHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVR 160
              SPKS    +  S  +H P S   SPG           P      P+G       +VR
Sbjct: 460 ---SPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKG-------RVR 509

Query: 161 TRGSIKRRPPSRRFR-RSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLS 219
            +   K  P +     +SQS        R   + +++ A         PS + AP     
Sbjct: 510 RKEEAKESPSAAGPEDKSQSK-------RRASNEKESAAPASPAPSPAPSPTPAPPQKEQ 562

Query: 220 --SEGAAGEGVRTLGPAEKPPLRRSP---SRTEKQEEDRATEEAKNGEKARRSSEEVDGQ 274
             +E      V T  PA  PP+  S      T+++E  R   E +   + +R  EE + +
Sbjct: 563 PPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERR 622

Query: 275 HPAQEEVPESPQTSGPEAENRC-----GSPREEKPAGEEAEMEKATEVKGERVQNEEVGP 329
             A+ +     +    EAE R         REE+ A E+A+ E+  + + ++ + E    
Sbjct: 623 LQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEAR 682

Query: 330 EHDSQETKKLEEGAAVKETPHSPPGGVKG-------------GDVPKQEKGKEKQQEGAV 376
             +  E ++LE     ++         K               +  +++  KE    G+ 
Sbjct: 683 SREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSS 742

Query: 377 LEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQD 413
            EP  + +     L+  +  + EP   +P+   P ++
Sbjct: 743 PEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKE 779



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 47/203 (23%), Positives = 73/203 (35%), Gaps = 35/203 (17%)

Query: 222 GAAGEGVRTLGPAEKPPLRRSP-----SRTEKQEEDRATEEAKN---------------- 260
           G  GE  +        P+RR P      + EK++++R  E+ K+                
Sbjct: 386 GERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPA 445

Query: 261 GEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGS--------PREEKPAGEEAEME 312
             +AR S+       P  +  P SP TS     + C S        P+   P G  A  +
Sbjct: 446 SPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPK 505

Query: 313 KATEVKGERVQN-EEVGPEHDSQETKKL---EEGAAVKETPHSPPGGVKGGDVPKQEKGK 368
                K E  ++    GPE  SQ  ++    +E AA      SP          K++   
Sbjct: 506 GRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPA 565

Query: 369 EKQQEGAVL--EPGCSPQTGPAQ 389
           E   + AVL   P  +P   P++
Sbjct: 566 ETPTDAAVLTSPPAPAPPVTPSK 588


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 70/328 (21%), Positives = 118/328 (35%), Gaps = 54/328 (16%)

Query: 132 SRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVE 191
           S  S++E+ P   ++PP  S  P   +     S+     S     ++S+     D  + +
Sbjct: 432 SEDSDSEQTP---EKPPSSSAPPSAPQ-----SLPEPVASAHSSSAESESTSDSDSSS-D 482

Query: 192 SSQQNGAKEEDGDEVLPSKSKAPGSP-------------LSSEGAAGEGVRTLGPAEKPP 238
           S  ++ + + + +E L + +  P  P             +S   A  EG R+  P  + P
Sbjct: 483 SESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHP 542

Query: 239 LRR--SPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRC 296
             +  S S T ++  +      K+  KA R+  E    HP +    +SP    P      
Sbjct: 543 ESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAP--HPGKRSCQKSPAQQEPPQRQTV 600

Query: 297 GSPREEKPAGEEAEMEKATEVKGERV-------QNEEVGPEHDSQETKKLEEGAAVKE-T 348
           G+ + +KP    A     T ++GER          ++   +    +TK     AA  E  
Sbjct: 601 GTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPK 660

Query: 349 PHSPPGGVK--------------GGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSS 394
           P  PP   K               G  P ++  +++  E   L P    Q  P     S 
Sbjct: 661 PAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR 720

Query: 395 EVQSEPAVPKPEDD------TPVQDTKM 416
                 AV   ED        P++DTK+
Sbjct: 721 TSGCRQAVVVQEDSRKDRLPLPLRDTKL 748



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 92/447 (20%), Positives = 156/447 (34%), Gaps = 59/447 (13%)

Query: 6   AETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGE 65
           AE+ +  D+ +S      +     +     ETPA +P   +PP +      K  L     
Sbjct: 469 AESESTSDSDSSSDSESESSSSDSEENEPLETPAPEP---EPPTT-----NKWQLDNWLT 520

Query: 66  EKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTP 125
           + S P A  PP+    + P     ++  + D A     +  K P  K+      +PP  P
Sbjct: 521 KVSQPAA--PPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAP 578

Query: 126 SSPGVRS-RPSEAEEVP-----VSFDQPPEGSHLPCYNKVRTRGSIKRRP---PSRRFRR 176
             PG RS + S A++ P     V   QP +          RT    +R P   P     +
Sbjct: 579 H-PGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQ 637

Query: 177 SQSDCGEL---GDFRAVESSQQNGAKEEDGDEVLPSKS-KAPGSPLSSEGAAGEGVRTLG 232
           +  D  ++   G  RA  S++   A     ++     S  AP   LS    A + V    
Sbjct: 638 TSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRT 697

Query: 233 P----------AEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVP 282
           P          ++ PP   S SRT    +    +E    ++      +     P ++  P
Sbjct: 698 PEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPP 757

Query: 283 ES--------------PQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVG 328
                           PQ  G  +  R    ++  PAG++   EK +     ++  +  G
Sbjct: 758 PQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQP-PAGKKHSSEKRSSDSSSKLAKKRKG 816

Query: 329 PEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPA 388
                 + KK+     +K    S     K     K  +   +  +  +L         P 
Sbjct: 817 EAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLP--------PP 868

Query: 389 QLETSSEVQSEPAVPKP--EDDTPVQD 413
            + +SS+  ++PA+ +   E DT  QD
Sbjct: 869 PVSSSSQKPAKPALKRSRREADTCGQD 895



 Score = 36.6 bits (83), Expect = 0.043
 Identities = 63/348 (18%), Positives = 123/348 (35%), Gaps = 53/348 (15%)

Query: 102 PGASPKSPGLK---------AMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSH 152
           P  SPK   +K         ++V+P   P  T   P + S+    ++ P ++ +P +G  
Sbjct: 242 PAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQD 301

Query: 153 LPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELG------------DFRAVESSQQNGAKE 200
                      S + +P    +R+   +  +L               ++VE +  N  + 
Sbjct: 302 QA------PSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSN--EV 353

Query: 201 EDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEE-DRATEEAK 259
              +E+L   + +   PL++         +  P      +   S T+ Q++ D +++   
Sbjct: 354 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS 413

Query: 260 NGEKARRSSEE-----VDGQHPAQEEVPESPQTSG--PEAENRCGSP------------- 299
           N ++   S  E      D +    E+ PE P +S   P A      P             
Sbjct: 414 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES 473

Query: 300 REEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKK--LEEGAAVKETPHSPPGGVK 357
             +  +  ++E E ++    E    E   PE +   T K  L+        P +PP G +
Sbjct: 474 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR 533

Query: 358 GGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKP 405
             + P++    +   + A  +   S    P    +S   ++ P  P P
Sbjct: 534 STEPPRRHPESKGSSDSATSQEH-SESKDPPPKSSSKAPRAPPEAPHP 580



 Score = 30.0 bits (66), Expect = 4.0
 Identities = 39/212 (18%), Positives = 81/212 (38%), Gaps = 16/212 (7%)

Query: 125 PSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKV--RTRGSIKRRPPSRRFR-----RS 177
           P   G R R +E ++ P       E       +K+  + +G  +R   +++ R     +S
Sbjct: 776 PPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKS 835

Query: 178 QSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKP 237
           QS         + ++     + +    E+LP    +  S   ++ A     R      + 
Sbjct: 836 QSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQD 895

Query: 238 PLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCG 297
           P + + S     ++    ++ +   K  RSS E  G   + +     P  S P   ++ G
Sbjct: 896 PPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGS--SGDTANPFPVPSLPNGNSKPG 953

Query: 298 SPR---EEKPAG----EEAEMEKATEVKGERV 322
            P+   +++ A     E  +M++  E+  +RV
Sbjct: 954 KPQVKFDKQQADLHMREAKKMKQKAELMTDRV 985


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 108/440 (24%), Positives = 148/440 (33%), Gaps = 97/440 (22%)

Query: 47  PPCSLPLFPPKVDLGQNGEEKSPPNASH--PPKFKVKSSPLIEKLQANLTFDPAALLPG- 103
           PP   PL PP     +      PP AS   PP  ++ +SPL E L  +   + + L P  
Sbjct: 443 PPEESPLSPPP----EESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPP 498

Query: 104 ----------ASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEA-------EEVPVS--- 143
                     +SP SP  ++ +SP    P +P+     S P EA       EE P+S   
Sbjct: 499 EESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPP 558

Query: 144 ----FDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAK 199
                  PPE S L          S    PP         +   L  F   E S  +   
Sbjct: 559 EELPTSPPPEASRL----SPPPEESPMSPPPEESPMSPPPEASRL--FPPFEESPLSPPP 612

Query: 200 EE-------DGDEVLPSKSKAPGSPLSSEGAAGEG------------VRTLGPAEKPPLR 240
           EE       +   + P    +P SP   E                   R   P E+ PL 
Sbjct: 613 EESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLS 672

Query: 241 RSP-----------SRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEE----VPESP 285
             P           SR     ED  T        A    E+     P +E     +PE P
Sbjct: 673 PPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEP 732

Query: 286 QTSGPEAENRCGSPREEK----PAGEEAEMEKATEVKGERVQNEE-----------VGPE 330
           Q   P +E    SPR E+    P  EE  +    E      Q EE           + P+
Sbjct: 733 QLC-PRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQ 791

Query: 331 ----HDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTG 386
               H S + ++L      +E PH  P   +    P+ E+     Q     EP  SP+  
Sbjct: 792 AEGPHLSPQPEELHLSPQTEE-PHLSPVPEEPCLSPQPEESHLSPQSE---EPCLSPR-- 845

Query: 387 PAQLETSSEVQSEPAVPKPE 406
           P +   S E++  P  P+PE
Sbjct: 846 PEESHLSPELEKPPLSPRPE 865



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 65/302 (21%), Positives = 100/302 (33%), Gaps = 34/302 (11%)

Query: 35  KETPASKPTRRKP----PCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQ 90
           +E+P S P    P    P +  L PP  D   +   +  P +  P   ++   P++ +L 
Sbjct: 604 EESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLS 663

Query: 91  ANLTFDPAALLPGASPKSPGLKA---MVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQP 147
                 P +  P  SP SP  +A      P  SP S P      S P E   + +  ++ 
Sbjct: 664 PPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEES 723

Query: 148 P--------------EGSHL---PCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAV 190
           P              EG HL   P    +  R       P            E       
Sbjct: 724 PLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEE--PCLCA 781

Query: 191 ESSQQNGAKEEDGDEVLPSKSKAPGSPLSSE----GAAGEGVRTLGPAEK--PPLRRSPS 244
              + + + + +G  + P   +   SP + E        E   +  P E    P    P 
Sbjct: 782 VPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPC 841

Query: 245 RTEKQEEDRATEEAKNGEKARRSSE--EVDGQHPAQEEVPESPQTSGPEAENRCGSPREE 302
            + + EE   + E +    + R  +  E  GQ PA EE+P  P    P      G P   
Sbjct: 842 LSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALS 901

Query: 303 KP 304
           +P
Sbjct: 902 EP 903



 Score = 30.0 bits (66), Expect = 4.0
 Identities = 32/106 (30%), Positives = 43/106 (40%), Gaps = 15/106 (14%)

Query: 36  ETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKS---SPLIEKLQAN 92
           E P  +P +   P  LPLFPP       GE    P    P   +      SPL E+L  +
Sbjct: 865 EKPPEEPGQCPAPEELPLFPPP------GEPSLSPLLGEPALSEPGEPPLSPLPEELPLS 918

Query: 93  LTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAE 138
            + +P +L P   P  P     + P  SP  T ++P   S   E E
Sbjct: 919 PSGEP-SLSPQLMPPDP-----LPPPLSPIITAAAPPALSPLGELE 958



 Score = 29.3 bits (64), Expect = 6.9
 Identities = 25/84 (29%), Positives = 36/84 (42%), Gaps = 5/84 (5%)

Query: 318  KGERVQ-NEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAV 376
            +G  VQ N+ +GP+          +G  V++    PP G +G   P Q    ++Q  GA+
Sbjct: 3759 QGPGVQTNQALGPKPQGLMPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGAL 3818

Query: 377  LEPGCSPQTGPAQLETSSEVQSEP 400
               G   Q     L T S V S P
Sbjct: 3819 GPQGPHRQV----LMTQSRVLSSP 3838


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 62/294 (21%), Positives = 107/294 (36%), Gaps = 20/294 (6%)

Query: 40  SKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAA 99
           S P+  KPP   P  P K    Q G EKS P  + PP     + P    L   L   P  
Sbjct: 297 SLPSPSKPPIQQPT-PGKPPAQQPGHEKSQPGPAKPP-----AQP--SGLTKPLAQQPGT 348

Query: 100 LLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKV 159
           + P   P  PG     +    P   P+      +PS  +  P +  QPP     P     
Sbjct: 349 VKPPVQP--PGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTP----A 402

Query: 160 RTRGSIKRRPPSRRFRRSQSDCGELG-DFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPL 218
           +  G  K  PP+++    +    + G    A          ++ G   +P++   PG   
Sbjct: 403 QQPGPAK--PPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTS 460

Query: 219 SSE-GAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPA 277
           + + G      +  GPA+ PP +  P++   Q+   A   ++     +   ++     P+
Sbjct: 461 AQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS 520

Query: 278 QEE--VPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGP 329
            ++    + P      A+     P   KP+ +++    +    G+ +Q   V P
Sbjct: 521 PQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSP 574



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 90/435 (20%), Positives = 160/435 (36%), Gaps = 87/435 (20%)

Query: 31   AAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQ 90
            +A +K +P  + T  K   +     PK DL +  E K PP             PL+++  
Sbjct: 670  SAVSKSSPQPQQTSPKKDAA-----PKQDLSKAPEPKKPP-------------PLVKQ-- 709

Query: 91   ANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEG 150
                      L G    SP  KA   P     S P+ P   S PSE ++ PV+ D+P + 
Sbjct: 710  --------PTLHG----SPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQP 757

Query: 151  SHLPCYNKVRTRGSIKRRP--PSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLP 208
              +     + +  S   +P  PS +  +SQ++       +  +S++ + +    G++V P
Sbjct: 758  KMVKPTTDLVSSSSATTKPDIPSSKV-QSQAEEKTTPPLK-TDSAKPSQSFPPTGEKVSP 815

Query: 209  SKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATE----EAKNGEKA 264
              SKA   P S      + +   GP+ +   ++     +K+EE +  +       + +  
Sbjct: 816  FDSKAIPRPASD----SKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPM 871

Query: 265  RRSSEEVDGQHP-AQEEVPESPQTSGPEAENR---------CGSPREEKPAGEEAEMEKA 314
             + S    G  P A + VP   Q+  P+ ++R           +P+ +    +E    K 
Sbjct: 872  PKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKL 931

Query: 315  --------TEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHS----------PPGGV 356
                    ++         + GP   S     +++  A  + P S          PP   
Sbjct: 932  FGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPA 991

Query: 357  KGGDVPKQEKGK-----EKQQEGAVLEPGCSPQTGPAQLETSSEVQSEP----------A 401
            K   V K+ K       E + E A        +  P  ++ S  + +EP           
Sbjct: 992  KSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEK 1051

Query: 402  VPKPEDDTPVQDTKM 416
             PKPE   P+  T++
Sbjct: 1052 SPKPESTCPLCKTEL 1066



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 102/440 (23%), Positives = 146/440 (33%), Gaps = 83/440 (18%)

Query: 5   PAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNG 64
           PA+  A    S  PS  Q   +   Q     +TPA +P   KPP +  +  PK  L Q  
Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPP-TQQVGTPK-PLAQQP 425

Query: 65  EEKSPPNASHPPKFKV-----------KSSPLIEKLQANLTFDPAALLPGASPKSPGLKA 113
             +SP  A  P K  V           ++ P     Q      P + LPG +   P    
Sbjct: 426 GLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPG 485

Query: 114 MVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRR 173
              P       P  PG    PS+    P S   PP+    P     +  GS K  PP   
Sbjct: 486 PAKP------PPQQPGSAKPPSQQ---PGSTKPPPQQPG-PAKPSPQQPGSTK--PP--- 530

Query: 174 FRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGS--PLSSEGAAGEGVR-- 229
                              SQQ G+ +    +  P+K  A  S  P+S  G +G+ ++  
Sbjct: 531 -------------------SQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTG-SGKPLQPP 570

Query: 230 TLGPAEKPPLRRSPSRT-----EKQEEDRATEEAKNGEKARRSSEEV-----DGQHPAQE 279
           T+ P+ K P  +   +T        E      E  N          V        +P   
Sbjct: 571 TVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLT 630

Query: 280 EVPE----SPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQE 335
           EV E    + Q       +    P   +P  + A +   + V     Q ++  P+ D+  
Sbjct: 631 EVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAP 690

Query: 336 TKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSE 395
            + L +       P  PP  VK   +      K KQ       P     + PA       
Sbjct: 691 KQDLSKA----PEPKKPPPLVKQPTLHGSPSAKAKQ------PPEADSLSKPAP------ 734

Query: 396 VQSEPAVPKPEDDTPVQDTK 415
              EP+VP  +D  PV D K
Sbjct: 735 -PKEPSVPSEQDKAPVADDK 753



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 97/417 (23%), Positives = 131/417 (31%), Gaps = 72/417 (17%)

Query: 20  VAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNAS-HPPKF 78
           ++QL+   R Q AA        P    PP +     P +   Q  +   PP  S  PP  
Sbjct: 45  LSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAE--SPSMHRKQELDSSHPPKQSGRPPDP 102

Query: 79  KVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSS--PGVRSRPSE 136
              + P + K +   TF     LPG SP +  LK   S         SS  PG  S  + 
Sbjct: 103 GRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNA 162

Query: 137 AEEV--------PVSFDQPPEGSHLPCYNKVRTRGSIKRRP-----PSRRFRRSQSDCGE 183
              V        P       E S      K +     + +P     P  + +  +    +
Sbjct: 163 LSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQ 222

Query: 184 LGDFRAVESSQQNGA-KEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKP----- 237
            G  R  +  QQ+G  K     +    KS+ PG+          G    GP + P     
Sbjct: 223 QGPGR--DPLQQDGTPKSISSQQPEKIKSQPPGT----------GKPIQGPTQTPQTDHA 270

Query: 238 --PLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENR 295
             PL+R  SR + ++ D        GE  + S      + P Q+  P  P    P  E  
Sbjct: 271 KLPLQRDASRPQTKQAD-----IVRGESVKPSLPS-PSKPPIQQPTPGKPPAQQPGHEK- 323

Query: 296 CGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGG 355
              P   KP                        P   S  TK L +     + P  PPG 
Sbjct: 324 -SQPGPAKP------------------------PAQPSGLTKPLAQQPGTVKPPVQPPGT 358

Query: 356 VKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQ 412
            K    P        QQ G+  E   S Q GP  L     V   PA        P Q
Sbjct: 359 TKPPAQPLGPAKPPAQQTGS--EKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQ 413



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 57/279 (20%), Positives = 102/279 (36%), Gaps = 28/279 (10%)

Query: 123  STPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCG 182
            ST        R S  +E   +FD+ PE  +    ++      +      RRF+  + +  
Sbjct: 1616 STSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELN-S 1674

Query: 183  ELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRS 242
             + D  + ESSQ+  +   D +  L  +S    SP   + + GEG  +L  +   P    
Sbjct: 1675 TIADKYSAESSQKKTSLYFDEEPELEMESLTD-SP--EDRSRGEGSSSLHASSFTPGTSP 1731

Query: 243  PSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREE 302
             S +   E+  ++   K GE  ++         P    + +S                EE
Sbjct: 1732 TSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSS---------------EE 1776

Query: 303  KPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKG-GDV 361
            +   EE E+ K  E + E  Q +       S++ K        +E P +PP  +    D 
Sbjct: 1777 EELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDA 1836

Query: 362  PKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEP 400
               E+ ++  +   +    CS        E S  ++S+P
Sbjct: 1837 SPTEELRQAAEMEELHRSSCS--------EYSPSIESDP 1867



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 101/443 (22%), Positives = 155/443 (34%), Gaps = 83/443 (18%)

Query: 5    PAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNG 64
            P  T ++   +A P   +L  +  ++     E    +    K   S+   PP V   Q  
Sbjct: 1138 PVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKV--KETLSMEKIPPMVTTDQKQ 1195

Query: 65   EE----KSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHS 120
            EE    K   +A    K   +   LI + +   + +   LL    P     K +     S
Sbjct: 1196 EESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTS 1255

Query: 121  PPSTPSSPGVRSRPSEAEE------VPVSFD---QP-------PEGS--HLPCYNKVRTR 162
             P       ++S+   AEE       P +     QP       P G+   LP  +   T+
Sbjct: 1256 APEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTK 1315

Query: 163  GSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSP--LSS 220
             +IK +P        Q  C    D   VE  ++   KE+D  +   S S+ P SP  LS 
Sbjct: 1316 -TIKEQP--------QPPCTAKPD--QVEPGKEKTEKEDDKSDT--SSSQQPKSPQGLSD 1362

Query: 221  EGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEE 280
             G + +G+ +        L   PS     E+D        G K    S+E     P+   
Sbjct: 1363 TGYSSDGISS-------SLGEIPSLIPTDEKD-----ILKGLKKDSFSQESSPSSPSDLA 1410

Query: 281  VPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEH--DSQETKK 338
              ES   S  EA+                    A E   ++ Q  EV PE   D ++T+ 
Sbjct: 1411 KLESTVLSILEAQ----------------ASTLADEKSEKKTQPHEVSPEQPKDQEKTQS 1454

Query: 339  LEE-------GAAVKETPHSPPGGVKGG---DVPKQEKGKEKQQEGAVLEPGCSPQTGPA 388
            L E          +KE+        K     D+P  +  KEK +    +     P     
Sbjct: 1455 LSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYD--- 1511

Query: 389  QLETSSEVQSEPAVPKPEDDTPV 411
             +E SSE ++ P VP+ +  T V
Sbjct: 1512 SVEESSESENSP-VPQRKRRTSV 1533



 Score = 31.2 bits (69), Expect = 1.8
 Identities = 21/59 (35%), Positives = 30/59 (50%), Gaps = 7/59 (11%)

Query: 71   NASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPG 129
            +A+ PPK K + +PL     ++L  D    L  + PKSP  K + SP      +P SPG
Sbjct: 3582 SATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSP--KVLYSPI-----SPLSPG 3633


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 62/294 (21%), Positives = 107/294 (36%), Gaps = 20/294 (6%)

Query: 40  SKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAA 99
           S P+  KPP   P  P K    Q G EKS P  + PP     + P    L   L   P  
Sbjct: 297 SLPSPSKPPIQQPT-PGKPPAQQPGHEKSQPGPAKPP-----AQP--SGLTKPLAQQPGT 348

Query: 100 LLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKV 159
           + P   P  PG     +    P   P+      +PS  +  P +  QPP     P     
Sbjct: 349 VKPPVQP--PGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTP----A 402

Query: 160 RTRGSIKRRPPSRRFRRSQSDCGELG-DFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPL 218
           +  G  K  PP+++    +    + G    A          ++ G   +P++   PG   
Sbjct: 403 QQPGPAK--PPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTS 460

Query: 219 SSE-GAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPA 277
           + + G      +  GPA+ PP +  P++   Q+   A   ++     +   ++     P+
Sbjct: 461 AQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPS 520

Query: 278 QEE--VPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGP 329
            ++    + P      A+     P   KP+ +++    +    G+ +Q   V P
Sbjct: 521 PQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSP 574



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 90/435 (20%), Positives = 160/435 (36%), Gaps = 87/435 (20%)

Query: 31   AAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQ 90
            +A +K +P  + T  K   +     PK DL +  E K PP             PL+++  
Sbjct: 670  SAVSKSSPQPQQTSPKKDAA-----PKQDLSKAPEPKKPP-------------PLVKQ-- 709

Query: 91   ANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEG 150
                      L G    SP  KA   P     S P+ P   S PSE ++ PV+ D+P + 
Sbjct: 710  --------PTLHG----SPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQP 757

Query: 151  SHLPCYNKVRTRGSIKRRP--PSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLP 208
              +     + +  S   +P  PS +  +SQ++       +  +S++ + +    G++V P
Sbjct: 758  KMVKPTTDLVSSSSATTKPDIPSSKV-QSQAEEKTTPPLK-TDSAKPSQSFPPTGEKVSP 815

Query: 209  SKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATE----EAKNGEKA 264
              SKA   P S      + +   GP+ +   ++     +K+EE +  +       + +  
Sbjct: 816  FDSKAIPRPASD----SKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPM 871

Query: 265  RRSSEEVDGQHP-AQEEVPESPQTSGPEAENR---------CGSPREEKPAGEEAEMEKA 314
             + S    G  P A + VP   Q+  P+ ++R           +P+ +    +E    K 
Sbjct: 872  PKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKL 931

Query: 315  --------TEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHS----------PPGGV 356
                    ++         + GP   S     +++  A  + P S          PP   
Sbjct: 932  FGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPA 991

Query: 357  KGGDVPKQEKGK-----EKQQEGAVLEPGCSPQTGPAQLETSSEVQSEP----------A 401
            K   V K+ K       E + E A        +  P  ++ S  + +EP           
Sbjct: 992  KSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEK 1051

Query: 402  VPKPEDDTPVQDTKM 416
             PKPE   P+  T++
Sbjct: 1052 SPKPESTCPLCKTEL 1066



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 102/440 (23%), Positives = 146/440 (33%), Gaps = 83/440 (18%)

Query: 5   PAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNG 64
           PA+  A    S  PS  Q   +   Q     +TPA +P   KPP +  +  PK  L Q  
Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPP-TQQVGTPK-PLAQQP 425

Query: 65  EEKSPPNASHPPKFKV-----------KSSPLIEKLQANLTFDPAALLPGASPKSPGLKA 113
             +SP  A  P K  V           ++ P     Q      P + LPG +   P    
Sbjct: 426 GLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPG 485

Query: 114 MVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRR 173
              P       P  PG    PS+    P S   PP+    P     +  GS K  PP   
Sbjct: 486 PAKP------PPQQPGSAKPPSQQ---PGSTKPPPQQPG-PAKPSPQQPGSTK--PP--- 530

Query: 174 FRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGS--PLSSEGAAGEGVR-- 229
                              SQQ G+ +    +  P+K  A  S  P+S  G +G+ ++  
Sbjct: 531 -------------------SQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTG-SGKPLQPP 570

Query: 230 TLGPAEKPPLRRSPSRT-----EKQEEDRATEEAKNGEKARRSSEEV-----DGQHPAQE 279
           T+ P+ K P  +   +T        E      E  N          V        +P   
Sbjct: 571 TVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLT 630

Query: 280 EVPE----SPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQE 335
           EV E    + Q       +    P   +P  + A +   + V     Q ++  P+ D+  
Sbjct: 631 EVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAP 690

Query: 336 TKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSE 395
            + L +       P  PP  VK   +      K KQ       P     + PA       
Sbjct: 691 KQDLSKA----PEPKKPPPLVKQPTLHGSPSAKAKQ------PPEADSLSKPAP------ 734

Query: 396 VQSEPAVPKPEDDTPVQDTK 415
              EP+VP  +D  PV D K
Sbjct: 735 -PKEPSVPSEQDKAPVADDK 753



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 97/417 (23%), Positives = 131/417 (31%), Gaps = 72/417 (17%)

Query: 20  VAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNAS-HPPKF 78
           ++QL+   R Q AA        P    PP +     P +   Q  +   PP  S  PP  
Sbjct: 45  LSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAE--SPSMHRKQELDSSHPPKQSGRPPDP 102

Query: 79  KVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSS--PGVRSRPSE 136
              + P + K +   TF     LPG SP +  LK   S         SS  PG  S  + 
Sbjct: 103 GRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNA 162

Query: 137 AEEV--------PVSFDQPPEGSHLPCYNKVRTRGSIKRRP-----PSRRFRRSQSDCGE 183
              V        P       E S      K +     + +P     P  + +  +    +
Sbjct: 163 LSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQ 222

Query: 184 LGDFRAVESSQQNGA-KEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKP----- 237
            G  R  +  QQ+G  K     +    KS+ PG+          G    GP + P     
Sbjct: 223 QGPGR--DPLQQDGTPKSISSQQPEKIKSQPPGT----------GKPIQGPTQTPQTDHA 270

Query: 238 --PLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENR 295
             PL+R  SR + ++ D        GE  + S      + P Q+  P  P    P  E  
Sbjct: 271 KLPLQRDASRPQTKQAD-----IVRGESVKPSLPS-PSKPPIQQPTPGKPPAQQPGHEK- 323

Query: 296 CGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGG 355
              P   KP                        P   S  TK L +     + P  PPG 
Sbjct: 324 -SQPGPAKP------------------------PAQPSGLTKPLAQQPGTVKPPVQPPGT 358

Query: 356 VKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQ 412
            K    P        QQ G+  E   S Q GP  L     V   PA        P Q
Sbjct: 359 TKPPAQPLGPAKPPAQQTGS--EKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQ 413



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 57/279 (20%), Positives = 102/279 (36%), Gaps = 28/279 (10%)

Query: 123  STPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCG 182
            ST        R S  +E   +FD+ PE  +    ++      +      RRF+  + +  
Sbjct: 1616 STSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELN-S 1674

Query: 183  ELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRS 242
             + D  + ESSQ+  +   D +  L  +S    SP   + + GEG  +L  +   P    
Sbjct: 1675 TIADKYSAESSQKKTSLYFDEEPELEMESLTD-SP--EDRSRGEGSSSLHASSFTPGTSP 1731

Query: 243  PSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREE 302
             S +   E+  ++   K GE  ++         P    + +S                EE
Sbjct: 1732 TSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSS---------------EE 1776

Query: 303  KPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKG-GDV 361
            +   EE E+ K  E + E  Q +       S++ K        +E P +PP  +    D 
Sbjct: 1777 EELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDA 1836

Query: 362  PKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEP 400
               E+ ++  +   +    CS        E S  ++S+P
Sbjct: 1837 SPTEELRQAAEMEELHRSSCS--------EYSPSIESDP 1867



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 101/443 (22%), Positives = 155/443 (34%), Gaps = 83/443 (18%)

Query: 5    PAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNG 64
            P  T ++   +A P   +L  +  ++     E    +    K   S+   PP V   Q  
Sbjct: 1138 PVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKV--KETLSMEKIPPMVTTDQKQ 1195

Query: 65   EE----KSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHS 120
            EE    K   +A    K   +   LI + +   + +   LL    P     K +     S
Sbjct: 1196 EESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTS 1255

Query: 121  PPSTPSSPGVRSRPSEAEE------VPVSFD---QP-------PEGS--HLPCYNKVRTR 162
             P       ++S+   AEE       P +     QP       P G+   LP  +   T+
Sbjct: 1256 APEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTK 1315

Query: 163  GSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSP--LSS 220
             +IK +P        Q  C    D   VE  ++   KE+D  +   S S+ P SP  LS 
Sbjct: 1316 -TIKEQP--------QPPCTAKPD--QVEPGKEKTEKEDDKSDT--SSSQQPKSPQGLSD 1362

Query: 221  EGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEE 280
             G + +G+ +        L   PS     E+D        G K    S+E     P+   
Sbjct: 1363 TGYSSDGISS-------SLGEIPSLIPTDEKD-----ILKGLKKDSFSQESSPSSPSDLA 1410

Query: 281  VPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEH--DSQETKK 338
              ES   S  EA+                    A E   ++ Q  EV PE   D ++T+ 
Sbjct: 1411 KLESTVLSILEAQ----------------ASTLADEKSEKKTQPHEVSPEQPKDQEKTQS 1454

Query: 339  LEE-------GAAVKETPHSPPGGVKGG---DVPKQEKGKEKQQEGAVLEPGCSPQTGPA 388
            L E          +KE+        K     D+P  +  KEK +    +     P     
Sbjct: 1455 LSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYD--- 1511

Query: 389  QLETSSEVQSEPAVPKPEDDTPV 411
             +E SSE ++ P VP+ +  T V
Sbjct: 1512 SVEESSESENSP-VPQRKRRTSV 1533



 Score = 31.2 bits (69), Expect = 1.8
 Identities = 21/59 (35%), Positives = 30/59 (50%), Gaps = 7/59 (11%)

Query: 71   NASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPG 129
            +A+ PPK K + +PL     ++L  D    L  + PKSP  K + SP      +P SPG
Sbjct: 3582 SATSPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSP--KVLYSPI-----SPLSPG 3633


>gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Homo
           sapiens]
          Length = 1632

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 60/262 (22%), Positives = 98/262 (37%), Gaps = 35/262 (13%)

Query: 103 GASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTR 162
           G   +S   +  ++  +SPP   S P    R     E   S D P   S +         
Sbjct: 110 GNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVT-------- 161

Query: 163 GSIKRRP-PSRRFRRSQSDCGELGDFRAVESSQQNGAKEED---GDEVLPSKSKAPGSPL 218
             I+  P PS R  R  +    +    A   +++   +E +    DE +  + K      
Sbjct: 162 -GIRAEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKR 220

Query: 219 SSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQ 278
               +     R L PAE+P   +S +RTEK+EE             R   EE   +   +
Sbjct: 221 RRVTSRERVARPL-PAEEPERAKSGTRTEKEEE-------------RDEKEEKRLRSQTK 266

Query: 279 EEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEK--------ATEVKGERVQNEEVGPE 330
           E  P+      P+ E R G   +E   G+E + +K        A + + E  + E+V P+
Sbjct: 267 EPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQ 326

Query: 331 HDSQETKKLEEGAAVKETPHSP 352
              ++ +  +E    K TP  P
Sbjct: 327 ISDEKDEDEKEEKRRKTTPKEP 348


>gi|46409304 glutamate-rich 1 [Homo sapiens]
          Length = 443

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 78/340 (22%), Positives = 134/340 (39%), Gaps = 40/340 (11%)

Query: 53  LFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASP--KSPG 110
           LFPP V  GQ   E       +PPK KV S  + +K    LT D  +  P A     + G
Sbjct: 17  LFPP-VPSGQGKREPQTLAVQNPPK-KVTSEKVSQKHAEPLT-DTGSETPTARRLYTASG 73

Query: 111 LKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPP 170
                 P    PS+  SP   S   + E+     DQP              R  I++   
Sbjct: 74  PPEGYVPCWPEPSSCGSPENASSGDDTEDQD-PHDQPK-------------RRRIRKHKS 119

Query: 171 SRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKA----PGSPLSSEGAAGE 226
            ++F+   +   E  +    +S  Q  ++ +  D    SK+K         +  + AAG 
Sbjct: 120 KKKFKNPNNVLIEQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGL 179

Query: 227 GVRTLGPA----EKPPLRRSPSRTEKQEEDRATEEAKN----GEKARRSSEEVDGQHPAQ 278
             +  G +     +          E  EED      ++    GE+  + + E DG   ++
Sbjct: 180 AAKAAGVSFMYQPEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASE 239

Query: 279 EEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEV--GPEHDSQET 336
           E++  + Q  G +A     S  +  PAGEE +++ A E  G     E++    E D ++T
Sbjct: 240 EDLTRARQEEGADA-----SEEDPTPAGEE-DVKDAREEDGVDTIEEDLTRAGEEDGKDT 293

Query: 337 KKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAV 376
           ++ E+GA   E   +  G  +G D  +++     +++  +
Sbjct: 294 RE-EDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTI 332


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 90/413 (21%), Positives = 145/413 (35%), Gaps = 50/413 (12%)

Query: 38  PASKPTRRKPPCSLPLFPPKVDLG--QNGEEKSPPNASHPPKFKVKSS--PLIEK----- 88
           P  K     PP  +    P   +G  +   E S   +S     +V ++  P  EK     
Sbjct: 439 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 498

Query: 89  LQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFD--Q 146
           LQA  T  PA       P+  G  A+      P     S    S  +++EE P +    Q
Sbjct: 499 LQAKPTSSPAK----GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 554

Query: 147 PPEGSHLP----CYNKVRTRGSIKRRPP---SRRFRRSQSDCGELGDFRAVESSQQNGAK 199
                 +P    C  K  T  S K  P    ++  R++ +     G   AV    Q  A+
Sbjct: 555 AKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAE 614

Query: 200 EEDGDE------------VLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKP--PLRRSPSR 245
           +    E            V   ++K+ G  L  + A+     +LG    P  P +  P+ 
Sbjct: 615 DSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTV 674

Query: 246 T----EKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPRE 301
           T    EKQE+  ++EE  + E+A  S  +V       +          P A+    +P +
Sbjct: 675 TQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 734

Query: 302 EKPAGEEAEMEKATEVKG--ERVQNEEV---GPEHDSQETKKLEEGAAVKETPHSPPGGV 356
              A  +A+    ++VK      QN  V   GP       K +   A  +  P    G  
Sbjct: 735 VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSS 794

Query: 357 KGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDT 409
           +     ++   +E+ +  A ++P        A L  + E   + A P P   T
Sbjct: 795 E-----EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 842



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 51/216 (23%), Positives = 83/216 (38%), Gaps = 12/216 (5%)

Query: 200 EEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAK 259
           E   +  L S+++  GS  +   AA  G+ + G A+      S S  E   E +A+E+  
Sbjct: 162 EPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKIL 221

Query: 260 NGEKARRSSEEVDGQHPAQEEVPESPQTSGPEA-ENRCGSPREEKPAGEEAEMEKATEVK 318
              + R +S    G  P +   P  P  +G  A + + G P E+  +  E   +   E  
Sbjct: 222 ---QVRAASAPAKGT-PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 277

Query: 319 GERVQNEEVGPEHDSQETKKLEEGAAVKETPHS----PPGGVKGGDVPKQEKGKEKQQEG 374
             +   +       SQ        A  KE+P       P G  G  V K + GK ++   
Sbjct: 278 AAKALLQAKASGKTSQVGAA---SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ 334

Query: 375 AVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTP 410
           +  E   S +  PAQ + S +     A   P  ++P
Sbjct: 335 SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 370



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 52/235 (22%), Positives = 92/235 (39%), Gaps = 25/235 (10%)

Query: 191 ESSQQNGAKEEDGDEVLPS-----KSKAPG--SPLSSEGAAGEGVRTLGPAEKPPLRRSP 243
           E S+ +  +  D +E  P+     ++KA G  S + +  A  +     G A  PP +  P
Sbjct: 260 EDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGP 319

Query: 244 SRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAEN-RCGS---- 298
           +   K +  +  E++++  +   S EE   Q     + P+    S P  E+ R G+    
Sbjct: 320 A-VAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAP 378

Query: 299 PREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKG 358
           PR+  PA  + ++ K  E    R  +EE   + ++       +   + ++P   P    G
Sbjct: 379 PRKTGPAAAQVQVGKQEE--DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 436

Query: 359 GDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQL---ETSSEVQSEPAVPKPEDDTP 410
                   G   +  G V      P T  AQ+   E  SE  SE +    + + P
Sbjct: 437 -------MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVP 484



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 94/408 (23%), Positives = 147/408 (36%), Gaps = 78/408 (19%)

Query: 29  EQAAAAKETPA-SKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIE 87
           E++ + +E PA +KP+ + P       P K +  + G   +PP  + P   +V+     E
Sbjct: 338 EESDSEEEAPAQAKPSGKAPQVRAASAPAK-ESPRKGAAPAPPRKTGPAAAQVQVGKQEE 396

Query: 88  KLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQP 147
             +++     +     A+  +    A V P    P    +  +   P      PV    P
Sbjct: 397 DSRSSSEESDSDREALAAMNA----AQVKPLGKSPQVKPASTMGMGPLGKGAGPV----P 448

Query: 148 PEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGD--- 204
           P              G +    PS +  + + D          ESS +  +   DG+   
Sbjct: 449 P--------------GKVGPATPSAQVGKWEEDS---------ESSSEESSDSSDGEVPT 485

Query: 205 EVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTE-KQEEDRATEEAKNGEK 263
            V P++ K+ G+ L ++        T  PA+ PP +  P   + K E+     E+     
Sbjct: 486 AVAPAQEKSLGNILQAK-------PTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESS 538

Query: 264 ARRSSEEVDGQHPAQEEVP--ESPQTSG-PEAENRCGS------------PRE----EKP 304
               SEE      A +  P  + PQT   P+  N   S            PR+      P
Sbjct: 539 DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP 598

Query: 305 AGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPG---GVKGGDV 361
           AG    +   T+   E   + E   E DS+E K    G AV        G    VK   V
Sbjct: 599 AGSSPAVAGGTQRPAEDSSSSE---ESDSEEEK---TGLAVTVGQAKSVGKGLQVKAASV 652

Query: 362 PKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDT 409
           P   KG   Q    VL PG   +TGP   +  +E Q +    + E D+
Sbjct: 653 P--VKGSLGQGTAPVL-PG---KTGPTVTQVKAEKQEDSESSEEESDS 694



 Score = 32.7 bits (73), Expect = 0.62
 Identities = 83/443 (18%), Positives = 148/443 (33%), Gaps = 64/443 (14%)

Query: 3    ERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQ 62
            +RPAE +++ + S S           E+   A     +K   +         P K  LGQ
Sbjct: 610  QRPAEDSSSSEESDSEE---------EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 660

Query: 63   NGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPP 122
                         P    K+ P + +++A    D  +    +  +S   +A  SP     
Sbjct: 661  GTA----------PVLPGKTGPTVTQVKAEKQEDSES----SEEESDSEEAAASPAQVKT 706

Query: 123  STPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRR------FRR 176
            S   +   ++ P+ A            G  +    + + R   K +PP R         R
Sbjct: 707  SVKKTQA-KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 765

Query: 177  SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVR---TLGP 233
              +    +G   A  +  Q G +E+ G     S S+     L+    +G+  +    L P
Sbjct: 766  GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 825

Query: 234  AEK---------PPLRRSPSRTEKQEED---RATEEAKNGEKARRSSEEVDGQHPAQEEV 281
            A++         PP +  PS  +  ++D    ++EE+ +  +A  +        P    V
Sbjct: 826  AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFV 885

Query: 282  PESPQTSGPEA----ENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETK 337
              +   +GP A         +PR+ + +      E          ++E+V P      T 
Sbjct: 886  DPNRSPAGPAATPAQAQAASTPRKARAS------ESTARSSSSESEDEDVIPATQCL-TP 938

Query: 338  KLEEGAAVKETPH---SPPGGVKGGDVPKQEK--GKEKQQEGAVLEPGCSPQTGPAQLET 392
             +        T H   +P   + G    K+       K+QEG   +     +  PA L  
Sbjct: 939  GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVS---KKNPASLPL 995

Query: 393  SSEVQSEPAVPKPEDDTPVQDTK 415
            +       A    E   PV  T+
Sbjct: 996  TQAALKVLAQKASEAQPPVARTQ 1018


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 90/413 (21%), Positives = 145/413 (35%), Gaps = 50/413 (12%)

Query: 38  PASKPTRRKPPCSLPLFPPKVDLG--QNGEEKSPPNASHPPKFKVKSS--PLIEK----- 88
           P  K     PP  +    P   +G  +   E S   +S     +V ++  P  EK     
Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575

Query: 89  LQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFD--Q 146
           LQA  T  PA       P+  G  A+      P     S    S  +++EE P +    Q
Sbjct: 576 LQAKPTSSPAK----GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 147 PPEGSHLP----CYNKVRTRGSIKRRPP---SRRFRRSQSDCGELGDFRAVESSQQNGAK 199
                 +P    C  K  T  S K  P    ++  R++ +     G   AV    Q  A+
Sbjct: 632 AKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAE 691

Query: 200 EEDGDE------------VLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKP--PLRRSPSR 245
           +    E            V   ++K+ G  L  + A+     +LG    P  P +  P+ 
Sbjct: 692 DSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTV 751

Query: 246 T----EKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPRE 301
           T    EKQE+  ++EE  + E+A  S  +V       +          P A+    +P +
Sbjct: 752 TQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811

Query: 302 EKPAGEEAEMEKATEVKG--ERVQNEEV---GPEHDSQETKKLEEGAAVKETPHSPPGGV 356
              A  +A+    ++VK      QN  V   GP       K +   A  +  P    G  
Sbjct: 812 VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSS 871

Query: 357 KGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDT 409
           +     ++   +E+ +  A ++P        A L  + E   + A P P   T
Sbjct: 872 E-----EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 919



 Score = 48.9 bits (115), Expect = 8e-06
 Identities = 90/450 (20%), Positives = 160/450 (35%), Gaps = 60/450 (13%)

Query: 3   ERPAETNANVDNSAS-PSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLF-----PP 56
           E+  +T  ++ + A+  +VA L      + +A      +  +  +   S+P F     P 
Sbjct: 130 EKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPG 189

Query: 57  KVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVS 116
            V  GQ  +  S   +S   +  V+  P ++  Q   +         ++ +SP  KA  +
Sbjct: 190 MVSAGQ-ADSSSEDTSSSSDETDVEGKPSVKPAQVKAS-------SVSTKESPARKAAPA 241

Query: 117 PFHSPPSTPSSPGVRSRPSEAEEVPVS-FDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFR 175
           P      TP   G    P++  + P    +   EGS         TR  +K      + R
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVR 301

Query: 176 RSQSDC----------GELGDFRAVESSQQNGAKEEDGDE-----------------VLP 208
            + +               G   AV S  + G  EED +                  +L 
Sbjct: 302 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361

Query: 209 SKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSS 268
           +K+    S + +  A  +     G A  PP +  P+   K +  +  E++++  +   S 
Sbjct: 362 AKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA-VAKAQAGKREEDSQSSSEESDSE 420

Query: 269 EEVDGQHPAQEEVPESPQTSGPEAEN-RCGS----PREEKPAGEEAEMEKATEVKGERVQ 323
           EE   Q     + P+    S P  E+ R G+    PR+  PA  + ++ K  E    R  
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE--DSRSS 478

Query: 324 NEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSP 383
           +EE   + ++       +   + ++P   P    G        G   +  G V      P
Sbjct: 479 SEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG-------MGPLGKGAGPVPPGKVGP 531

Query: 384 QTGPAQL---ETSSEVQSEPAVPKPEDDTP 410
            T  AQ+   E  SE  SE +    + + P
Sbjct: 532 ATPSAQVGKWEEDSESSSEESSDSSDGEVP 561



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 86/453 (18%), Positives = 154/453 (33%), Gaps = 77/453 (16%)

Query: 3    ERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQ 62
            +RPAE +++ + S S           E+   A     +K   +         P K  LGQ
Sbjct: 687  QRPAEDSSSSEESDSEE---------EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737

Query: 63   NGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPP 122
                         P    K+ P + +++A    D  +    +  +S   +A  SP     
Sbjct: 738  GTA----------PVLPGKTGPTVTQVKAEKQEDSES----SEEESDSEEAAASPAQVKT 783

Query: 123  STPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRR------FRR 176
            S   +   ++ P+ A            G  +    + + R   K +PP R         R
Sbjct: 784  SVKKTQA-KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 842

Query: 177  SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVR---TLGP 233
              +    +G   A  +  Q G +E+ G     S S+     L+    +G+  +    L P
Sbjct: 843  GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902

Query: 234  AEK---------PPLRRSPSRTEKQEED---RATEEAKNGEKARRSSEEVDGQHPAQEEV 281
            A++         PP +  PS  +  ++D    ++EE+ +  +A  +        P    V
Sbjct: 903  AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFV 962

Query: 282  PESPQTSGPEA----ENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETK 337
              +   +GP A         +PR+ + +      E          ++E+V P      T 
Sbjct: 963  DPNRSPAGPAATPAQAQAASTPRKARAS------ESTARSSSSESEDEDVIPATQCL-TP 1015

Query: 338  KLEEGAAVKETPH---SPPGGVKGGDVPKQEK--GKEKQQEGAVLE--------PGCSPQ 384
             +        T H   +P   + G    K+       K+QEG   +        P  SPQ
Sbjct: 1016 GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQ 1075

Query: 385  TGPAQLETSS--------EVQSEPAVPKPEDDT 409
            +   Q + ++        EVQ     P+  DD+
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDS 1108


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 90/413 (21%), Positives = 145/413 (35%), Gaps = 50/413 (12%)

Query: 38  PASKPTRRKPPCSLPLFPPKVDLG--QNGEEKSPPNASHPPKFKVKSS--PLIEK----- 88
           P  K     PP  +    P   +G  +   E S   +S     +V ++  P  EK     
Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575

Query: 89  LQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFD--Q 146
           LQA  T  PA       P+  G  A+      P     S    S  +++EE P +    Q
Sbjct: 576 LQAKPTSSPAK----GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 147 PPEGSHLP----CYNKVRTRGSIKRRPP---SRRFRRSQSDCGELGDFRAVESSQQNGAK 199
                 +P    C  K  T  S K  P    ++  R++ +     G   AV    Q  A+
Sbjct: 632 AKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAE 691

Query: 200 EEDGDE------------VLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKP--PLRRSPSR 245
           +    E            V   ++K+ G  L  + A+     +LG    P  P +  P+ 
Sbjct: 692 DSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTV 751

Query: 246 T----EKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPRE 301
           T    EKQE+  ++EE  + E+A  S  +V       +          P A+    +P +
Sbjct: 752 TQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811

Query: 302 EKPAGEEAEMEKATEVKG--ERVQNEEV---GPEHDSQETKKLEEGAAVKETPHSPPGGV 356
              A  +A+    ++VK      QN  V   GP       K +   A  +  P    G  
Sbjct: 812 VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSS 871

Query: 357 KGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDT 409
           +     ++   +E+ +  A ++P        A L  + E   + A P P   T
Sbjct: 872 E-----EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 919



 Score = 48.9 bits (115), Expect = 8e-06
 Identities = 90/450 (20%), Positives = 160/450 (35%), Gaps = 60/450 (13%)

Query: 3   ERPAETNANVDNSAS-PSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLF-----PP 56
           E+  +T  ++ + A+  +VA L      + +A      +  +  +   S+P F     P 
Sbjct: 130 EKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPG 189

Query: 57  KVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVS 116
            V  GQ  +  S   +S   +  V+  P ++  Q   +         ++ +SP  KA  +
Sbjct: 190 MVSAGQ-ADSSSEDTSSSSDETDVEGKPSVKPAQVKAS-------SVSTKESPARKAAPA 241

Query: 117 PFHSPPSTPSSPGVRSRPSEAEEVPVS-FDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFR 175
           P      TP   G    P++  + P    +   EGS         TR  +K      + R
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVR 301

Query: 176 RSQSDC----------GELGDFRAVESSQQNGAKEEDGDE-----------------VLP 208
            + +               G   AV S  + G  EED +                  +L 
Sbjct: 302 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361

Query: 209 SKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSS 268
           +K+    S + +  A  +     G A  PP +  P+   K +  +  E++++  +   S 
Sbjct: 362 AKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA-VAKAQAGKREEDSQSSSEESDSE 420

Query: 269 EEVDGQHPAQEEVPESPQTSGPEAEN-RCGS----PREEKPAGEEAEMEKATEVKGERVQ 323
           EE   Q     + P+    S P  E+ R G+    PR+  PA  + ++ K  E    R  
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE--DSRSS 478

Query: 324 NEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSP 383
           +EE   + ++       +   + ++P   P    G        G   +  G V      P
Sbjct: 479 SEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG-------MGPLGKGAGPVPPGKVGP 531

Query: 384 QTGPAQL---ETSSEVQSEPAVPKPEDDTP 410
            T  AQ+   E  SE  SE +    + + P
Sbjct: 532 ATPSAQVGKWEEDSESSSEESSDSSDGEVP 561



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 74/356 (20%), Positives = 130/356 (36%), Gaps = 62/356 (17%)

Query: 5    PAETNANVDNSASPSVAQLAGRFREQAAAAKE-----------TPASKPTRRKPPCSLPL 53
            PA T A    +++P  A+ +      +++  E           TP  +      P + P 
Sbjct: 971  PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 1030

Query: 54   FPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKA 113
              PK  +      K     S   K +  ++ + +K  A+L    AAL      K    KA
Sbjct: 1031 IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAAL------KVLAQKA 1084

Query: 114  MVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRR 173
                     S    P  R++PS   +  V     P  S  P    V+ +G+ K R P   
Sbjct: 1085 ---------SEAQPPVARTQPSSGVDSAVG--TLPATS--PQSTSVQAKGTNKLRKPK-- 1129

Query: 174  FRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAG-EGVRTLG 232
                            +   QQ     E  D+   S   + GS    EG  G +   TLG
Sbjct: 1130 ----------------LPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLG 1173

Query: 233  PAEKPPLRRSPSRTEKQEEDRATEEAKNG----EKARRSSEEVDGQHPAQEEVPE-SPQT 287
            P        +PSRTE   E+ A E +++      ++  S     G  PA  +  + +P+ 
Sbjct: 1174 P--------TPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKL 1225

Query: 288  SGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGA 343
                + +   + +++    +EA+ ++A  +   +   +E       Q+++K ++GA
Sbjct: 1226 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGA 1281



 Score = 32.7 bits (73), Expect = 0.62
 Identities = 83/443 (18%), Positives = 148/443 (33%), Gaps = 64/443 (14%)

Query: 3    ERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQ 62
            +RPAE +++ + S S           E+   A     +K   +         P K  LGQ
Sbjct: 687  QRPAEDSSSSEESDSEE---------EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737

Query: 63   NGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPP 122
                         P    K+ P + +++A    D  +    +  +S   +A  SP     
Sbjct: 738  GTA----------PVLPGKTGPTVTQVKAEKQEDSES----SEEESDSEEAAASPAQVKT 783

Query: 123  STPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRR------FRR 176
            S   +   ++ P+ A            G  +    + + R   K +PP R         R
Sbjct: 784  SVKKTQA-KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 842

Query: 177  SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVR---TLGP 233
              +    +G   A  +  Q G +E+ G     S S+     L+    +G+  +    L P
Sbjct: 843  GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902

Query: 234  AEK---------PPLRRSPSRTEKQEED---RATEEAKNGEKARRSSEEVDGQHPAQEEV 281
            A++         PP +  PS  +  ++D    ++EE+ +  +A  +        P    V
Sbjct: 903  AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFV 962

Query: 282  PESPQTSGPEA----ENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETK 337
              +   +GP A         +PR+ + +      E          ++E+V P      T 
Sbjct: 963  DPNRSPAGPAATPAQAQAASTPRKARAS------ESTARSSSSESEDEDVIPATQCL-TP 1015

Query: 338  KLEEGAAVKETPH---SPPGGVKGGDVPKQEK--GKEKQQEGAVLEPGCSPQTGPAQLET 392
             +        T H   +P   + G    K+       K+QEG   +     +  PA L  
Sbjct: 1016 GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVS---KKNPASLPL 1072

Query: 393  SSEVQSEPAVPKPEDDTPVQDTK 415
            +       A    E   PV  T+
Sbjct: 1073 TQAALKVLAQKASEAQPPVARTQ 1095


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 90/413 (21%), Positives = 145/413 (35%), Gaps = 50/413 (12%)

Query: 38  PASKPTRRKPPCSLPLFPPKVDLG--QNGEEKSPPNASHPPKFKVKSS--PLIEK----- 88
           P  K     PP  +    P   +G  +   E S   +S     +V ++  P  EK     
Sbjct: 439 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 498

Query: 89  LQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFD--Q 146
           LQA  T  PA       P+  G  A+      P     S    S  +++EE P +    Q
Sbjct: 499 LQAKPTSSPAK----GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 554

Query: 147 PPEGSHLP----CYNKVRTRGSIKRRPP---SRRFRRSQSDCGELGDFRAVESSQQNGAK 199
                 +P    C  K  T  S K  P    ++  R++ +     G   AV    Q  A+
Sbjct: 555 AKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAE 614

Query: 200 EEDGDE------------VLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKP--PLRRSPSR 245
           +    E            V   ++K+ G  L  + A+     +LG    P  P +  P+ 
Sbjct: 615 DSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTV 674

Query: 246 T----EKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPRE 301
           T    EKQE+  ++EE  + E+A  S  +V       +          P A+    +P +
Sbjct: 675 TQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 734

Query: 302 EKPAGEEAEMEKATEVKG--ERVQNEEV---GPEHDSQETKKLEEGAAVKETPHSPPGGV 356
              A  +A+    ++VK      QN  V   GP       K +   A  +  P    G  
Sbjct: 735 VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSS 794

Query: 357 KGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDT 409
           +     ++   +E+ +  A ++P        A L  + E   + A P P   T
Sbjct: 795 E-----EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 842



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 51/216 (23%), Positives = 83/216 (38%), Gaps = 12/216 (5%)

Query: 200 EEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAK 259
           E   +  L S+++  GS  +   AA  G+ + G A+      S S  E   E +A+E+  
Sbjct: 162 EPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKIL 221

Query: 260 NGEKARRSSEEVDGQHPAQEEVPESPQTSGPEA-ENRCGSPREEKPAGEEAEMEKATEVK 318
              + R +S    G  P +   P  P  +G  A + + G P E+  +  E   +   E  
Sbjct: 222 ---QVRAASAPAKGT-PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 277

Query: 319 GERVQNEEVGPEHDSQETKKLEEGAAVKETPHS----PPGGVKGGDVPKQEKGKEKQQEG 374
             +   +       SQ        A  KE+P       P G  G  V K + GK ++   
Sbjct: 278 AAKALLQAKASGKTSQVGAA---SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ 334

Query: 375 AVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTP 410
           +  E   S +  PAQ + S +     A   P  ++P
Sbjct: 335 SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 370



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 52/235 (22%), Positives = 92/235 (39%), Gaps = 25/235 (10%)

Query: 191 ESSQQNGAKEEDGDEVLPS-----KSKAPG--SPLSSEGAAGEGVRTLGPAEKPPLRRSP 243
           E S+ +  +  D +E  P+     ++KA G  S + +  A  +     G A  PP +  P
Sbjct: 260 EDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGP 319

Query: 244 SRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAEN-RCGS---- 298
           +   K +  +  E++++  +   S EE   Q     + P+    S P  E+ R G+    
Sbjct: 320 A-VAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAP 378

Query: 299 PREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKG 358
           PR+  PA  + ++ K  E    R  +EE   + ++       +   + ++P   P    G
Sbjct: 379 PRKTGPAAAQVQVGKQEE--DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 436

Query: 359 GDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQL---ETSSEVQSEPAVPKPEDDTP 410
                   G   +  G V      P T  AQ+   E  SE  SE +    + + P
Sbjct: 437 -------MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVP 484



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 74/356 (20%), Positives = 130/356 (36%), Gaps = 62/356 (17%)

Query: 5    PAETNANVDNSASPSVAQLAGRFREQAAAAKE-----------TPASKPTRRKPPCSLPL 53
            PA T A    +++P  A+ +      +++  E           TP  +      P + P 
Sbjct: 894  PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 953

Query: 54   FPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKA 113
              PK  +      K     S   K +  ++ + +K  A+L    AAL      K    KA
Sbjct: 954  IAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAAL------KVLAQKA 1007

Query: 114  MVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRR 173
                     S    P  R++PS   +  V     P  S  P    V+ +G+ K R P   
Sbjct: 1008 ---------SEAQPPVARTQPSSGVDSAVG--TLPATS--PQSTSVQAKGTNKLRKPK-- 1052

Query: 174  FRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAG-EGVRTLG 232
                            +   QQ     E  D+   S   + GS    EG  G +   TLG
Sbjct: 1053 ----------------LPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLG 1096

Query: 233  PAEKPPLRRSPSRTEKQEEDRATEEAKNG----EKARRSSEEVDGQHPAQEEVPE-SPQT 287
            P        +PSRTE   E+ A E +++      ++  S     G  PA  +  + +P+ 
Sbjct: 1097 P--------TPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKL 1148

Query: 288  SGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGA 343
                + +   + +++    +EA+ ++A  +   +   +E       Q+++K ++GA
Sbjct: 1149 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGA 1204



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 94/408 (23%), Positives = 147/408 (36%), Gaps = 78/408 (19%)

Query: 29  EQAAAAKETPA-SKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIE 87
           E++ + +E PA +KP+ + P       P K +  + G   +PP  + P   +V+     E
Sbjct: 338 EESDSEEEAPAQAKPSGKAPQVRAASAPAK-ESPRKGAAPAPPRKTGPAAAQVQVGKQEE 396

Query: 88  KLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQP 147
             +++     +     A+  +    A V P    P    +  +   P      PV    P
Sbjct: 397 DSRSSSEESDSDREALAAMNA----AQVKPLGKSPQVKPASTMGMGPLGKGAGPV----P 448

Query: 148 PEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGD--- 204
           P              G +    PS +  + + D          ESS +  +   DG+   
Sbjct: 449 P--------------GKVGPATPSAQVGKWEEDS---------ESSSEESSDSSDGEVPT 485

Query: 205 EVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTE-KQEEDRATEEAKNGEK 263
            V P++ K+ G+ L ++        T  PA+ PP +  P   + K E+     E+     
Sbjct: 486 AVAPAQEKSLGNILQAK-------PTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESS 538

Query: 264 ARRSSEEVDGQHPAQEEVP--ESPQTSG-PEAENRCGS------------PRE----EKP 304
               SEE      A +  P  + PQT   P+  N   S            PR+      P
Sbjct: 539 DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP 598

Query: 305 AGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPG---GVKGGDV 361
           AG    +   T+   E   + E   E DS+E K    G AV        G    VK   V
Sbjct: 599 AGSSPAVAGGTQRPAEDSSSSE---ESDSEEEK---TGLAVTVGQAKSVGKGLQVKAASV 652

Query: 362 PKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDT 409
           P   KG   Q    VL PG   +TGP   +  +E Q +    + E D+
Sbjct: 653 P--VKGSLGQGTAPVL-PG---KTGPTVTQVKAEKQEDSESSEEESDS 694



 Score = 32.7 bits (73), Expect = 0.62
 Identities = 83/443 (18%), Positives = 148/443 (33%), Gaps = 64/443 (14%)

Query: 3    ERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQ 62
            +RPAE +++ + S S           E+   A     +K   +         P K  LGQ
Sbjct: 610  QRPAEDSSSSEESDSEE---------EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 660

Query: 63   NGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPP 122
                         P    K+ P + +++A    D  +    +  +S   +A  SP     
Sbjct: 661  GTA----------PVLPGKTGPTVTQVKAEKQEDSES----SEEESDSEEAAASPAQVKT 706

Query: 123  STPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRR------FRR 176
            S   +   ++ P+ A            G  +    + + R   K +PP R         R
Sbjct: 707  SVKKTQA-KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 765

Query: 177  SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVR---TLGP 233
              +    +G   A  +  Q G +E+ G     S S+     L+    +G+  +    L P
Sbjct: 766  GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 825

Query: 234  AEK---------PPLRRSPSRTEKQEED---RATEEAKNGEKARRSSEEVDGQHPAQEEV 281
            A++         PP +  PS  +  ++D    ++EE+ +  +A  +        P    V
Sbjct: 826  AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFV 885

Query: 282  PESPQTSGPEA----ENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETK 337
              +   +GP A         +PR+ + +      E          ++E+V P      T 
Sbjct: 886  DPNRSPAGPAATPAQAQAASTPRKARAS------ESTARSSSSESEDEDVIPATQCL-TP 938

Query: 338  KLEEGAAVKETPH---SPPGGVKGGDVPKQEK--GKEKQQEGAVLEPGCSPQTGPAQLET 392
             +        T H   +P   + G    K+       K+QEG   +     +  PA L  
Sbjct: 939  GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVS---KKNPASLPL 995

Query: 393  SSEVQSEPAVPKPEDDTPVQDTK 415
            +       A    E   PV  T+
Sbjct: 996  TQAALKVLAQKASEAQPPVARTQ 1018


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 90/413 (21%), Positives = 145/413 (35%), Gaps = 50/413 (12%)

Query: 38  PASKPTRRKPPCSLPLFPPKVDLG--QNGEEKSPPNASHPPKFKVKSS--PLIEK----- 88
           P  K     PP  +    P   +G  +   E S   +S     +V ++  P  EK     
Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575

Query: 89  LQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFD--Q 146
           LQA  T  PA       P+  G  A+      P     S    S  +++EE P +    Q
Sbjct: 576 LQAKPTSSPAK----GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 147 PPEGSHLP----CYNKVRTRGSIKRRPP---SRRFRRSQSDCGELGDFRAVESSQQNGAK 199
                 +P    C  K  T  S K  P    ++  R++ +     G   AV    Q  A+
Sbjct: 632 AKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAE 691

Query: 200 EEDGDE------------VLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKP--PLRRSPSR 245
           +    E            V   ++K+ G  L  + A+     +LG    P  P +  P+ 
Sbjct: 692 DSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTV 751

Query: 246 T----EKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPRE 301
           T    EKQE+  ++EE  + E+A  S  +V       +          P A+    +P +
Sbjct: 752 TQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811

Query: 302 EKPAGEEAEMEKATEVKG--ERVQNEEV---GPEHDSQETKKLEEGAAVKETPHSPPGGV 356
              A  +A+    ++VK      QN  V   GP       K +   A  +  P    G  
Sbjct: 812 VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSS 871

Query: 357 KGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDT 409
           +     ++   +E+ +  A ++P        A L  + E   + A P P   T
Sbjct: 872 E-----EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 919



 Score = 48.9 bits (115), Expect = 8e-06
 Identities = 90/450 (20%), Positives = 160/450 (35%), Gaps = 60/450 (13%)

Query: 3   ERPAETNANVDNSAS-PSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLF-----PP 56
           E+  +T  ++ + A+  +VA L      + +A      +  +  +   S+P F     P 
Sbjct: 130 EKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPG 189

Query: 57  KVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVS 116
            V  GQ  +  S   +S   +  V+  P ++  Q   +         ++ +SP  KA  +
Sbjct: 190 MVSAGQ-ADSSSEDTSSSSDETDVEGKPSVKPAQVKAS-------SVSTKESPARKAAPA 241

Query: 117 PFHSPPSTPSSPGVRSRPSEAEEVPVS-FDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFR 175
           P      TP   G    P++  + P    +   EGS         TR  +K      + R
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVR 301

Query: 176 RSQSDC----------GELGDFRAVESSQQNGAKEEDGDE-----------------VLP 208
            + +               G   AV S  + G  EED +                  +L 
Sbjct: 302 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361

Query: 209 SKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSS 268
           +K+    S + +  A  +     G A  PP +  P+   K +  +  E++++  +   S 
Sbjct: 362 AKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA-VAKAQAGKREEDSQSSSEESDSE 420

Query: 269 EEVDGQHPAQEEVPESPQTSGPEAEN-RCGS----PREEKPAGEEAEMEKATEVKGERVQ 323
           EE   Q     + P+    S P  E+ R G+    PR+  PA  + ++ K  E    R  
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE--DSRSS 478

Query: 324 NEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSP 383
           +EE   + ++       +   + ++P   P    G        G   +  G V      P
Sbjct: 479 SEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG-------MGPLGKGAGPVPPGKVGP 531

Query: 384 QTGPAQL---ETSSEVQSEPAVPKPEDDTP 410
            T  AQ+   E  SE  SE +    + + P
Sbjct: 532 ATPSAQVGKWEEDSESSSEESSDSSDGEVP 561



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 68/353 (19%), Positives = 134/353 (37%), Gaps = 57/353 (16%)

Query: 18   PSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPK 77
            PS AQ AG+  +  ++++E+ +          +  + PP + +  N     P  A+ P +
Sbjct: 921  PSAAQ-AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGP--AATPAQ 977

Query: 78   FKVKSSPLIEKLQANLTFDPAA------LLPGASPKSPGLKAMV--SPFHSPPSTPSSPG 129
             +  S+P   +   +     ++      ++P     +PG++  V   P   P   P +  
Sbjct: 978  AQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKA-S 1036

Query: 130  VRSRPSEAEEVPVSFDQPPEG-------------SHLPCYNKVRTRGSIKRRPPSRRFRR 176
            +    S  E   +S  +  EG             +  P    V+ +G+ K R P      
Sbjct: 1037 MAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPK----- 1091

Query: 177  SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAG-EGVRTLGPAE 235
                         +   QQ     E  D+   S   + GS    EG  G +   TLGP  
Sbjct: 1092 -------------LPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGP-- 1136

Query: 236  KPPLRRSPSRTEKQEEDRATEEAKNG----EKARRSSEEVDGQHPAQEEVPE-SPQTSGP 290
                  +PSRTE   E+ A E +++      ++  S     G  PA  +  + +P+    
Sbjct: 1137 ------TPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSS 1190

Query: 291  EAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGA 343
             + +   + +++    +EA+ ++A  +   +   +E       Q+++K ++GA
Sbjct: 1191 PSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGA 1243



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 86/453 (18%), Positives = 154/453 (33%), Gaps = 77/453 (16%)

Query: 3    ERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQ 62
            +RPAE +++ + S S           E+   A     +K   +         P K  LGQ
Sbjct: 687  QRPAEDSSSSEESDSEE---------EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737

Query: 63   NGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPP 122
                         P    K+ P + +++A    D  +    +  +S   +A  SP     
Sbjct: 738  GTA----------PVLPGKTGPTVTQVKAEKQEDSES----SEEESDSEEAAASPAQVKT 783

Query: 123  STPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRR------FRR 176
            S   +   ++ P+ A            G  +    + + R   K +PP R         R
Sbjct: 784  SVKKTQA-KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 842

Query: 177  SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVR---TLGP 233
              +    +G   A  +  Q G +E+ G     S S+     L+    +G+  +    L P
Sbjct: 843  GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902

Query: 234  AEK---------PPLRRSPSRTEKQEED---RATEEAKNGEKARRSSEEVDGQHPAQEEV 281
            A++         PP +  PS  +  ++D    ++EE+ +  +A  +        P    V
Sbjct: 903  AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFV 962

Query: 282  PESPQTSGPEA----ENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETK 337
              +   +GP A         +PR+ + +      E          ++E+V P      T 
Sbjct: 963  DPNRSPAGPAATPAQAQAASTPRKARAS------ESTARSSSSESEDEDVIPATQCL-TP 1015

Query: 338  KLEEGAAVKETPH---SPPGGVKGGDVPKQEK--GKEKQQEGAVLE--------PGCSPQ 384
             +        T H   +P   + G    K+       K+QEG   +        P  SPQ
Sbjct: 1016 GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQ 1075

Query: 385  TGPAQLETSS--------EVQSEPAVPKPEDDT 409
            +   Q + ++        EVQ     P+  DD+
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDS 1108


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 90/413 (21%), Positives = 145/413 (35%), Gaps = 50/413 (12%)

Query: 38  PASKPTRRKPPCSLPLFPPKVDLG--QNGEEKSPPNASHPPKFKVKSS--PLIEK----- 88
           P  K     PP  +    P   +G  +   E S   +S     +V ++  P  EK     
Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575

Query: 89  LQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFD--Q 146
           LQA  T  PA       P+  G  A+      P     S    S  +++EE P +    Q
Sbjct: 576 LQAKPTSSPAK----GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631

Query: 147 PPEGSHLP----CYNKVRTRGSIKRRPP---SRRFRRSQSDCGELGDFRAVESSQQNGAK 199
                 +P    C  K  T  S K  P    ++  R++ +     G   AV    Q  A+
Sbjct: 632 AKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAE 691

Query: 200 EEDGDE------------VLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKP--PLRRSPSR 245
           +    E            V   ++K+ G  L  + A+     +LG    P  P +  P+ 
Sbjct: 692 DSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTV 751

Query: 246 T----EKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPRE 301
           T    EKQE+  ++EE  + E+A  S  +V       +          P A+    +P +
Sbjct: 752 TQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811

Query: 302 EKPAGEEAEMEKATEVKG--ERVQNEEV---GPEHDSQETKKLEEGAAVKETPHSPPGGV 356
              A  +A+    ++VK      QN  V   GP       K +   A  +  P    G  
Sbjct: 812 VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSS 871

Query: 357 KGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDT 409
           +     ++   +E+ +  A ++P        A L  + E   + A P P   T
Sbjct: 872 E-----EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 919



 Score = 48.9 bits (115), Expect = 8e-06
 Identities = 90/450 (20%), Positives = 160/450 (35%), Gaps = 60/450 (13%)

Query: 3   ERPAETNANVDNSAS-PSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLF-----PP 56
           E+  +T  ++ + A+  +VA L      + +A      +  +  +   S+P F     P 
Sbjct: 130 EKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPG 189

Query: 57  KVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVS 116
            V  GQ  +  S   +S   +  V+  P ++  Q   +         ++ +SP  KA  +
Sbjct: 190 MVSAGQ-ADSSSEDTSSSSDETDVEGKPSVKPAQVKAS-------SVSTKESPARKAAPA 241

Query: 117 PFHSPPSTPSSPGVRSRPSEAEEVPVS-FDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFR 175
           P      TP   G    P++  + P    +   EGS         TR  +K      + R
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVR 301

Query: 176 RSQSDC----------GELGDFRAVESSQQNGAKEEDGDE-----------------VLP 208
            + +               G   AV S  + G  EED +                  +L 
Sbjct: 302 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361

Query: 209 SKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSS 268
           +K+    S + +  A  +     G A  PP +  P+   K +  +  E++++  +   S 
Sbjct: 362 AKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA-VAKAQAGKREEDSQSSSEESDSE 420

Query: 269 EEVDGQHPAQEEVPESPQTSGPEAEN-RCGS----PREEKPAGEEAEMEKATEVKGERVQ 323
           EE   Q     + P+    S P  E+ R G+    PR+  PA  + ++ K  E    R  
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE--DSRSS 478

Query: 324 NEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSP 383
           +EE   + ++       +   + ++P   P    G        G   +  G V      P
Sbjct: 479 SEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG-------MGPLGKGAGPVPPGKVGP 531

Query: 384 QTGPAQL---ETSSEVQSEPAVPKPEDDTP 410
            T  AQ+   E  SE  SE +    + + P
Sbjct: 532 ATPSAQVGKWEEDSESSSEESSDSSDGEVP 561



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 56/304 (18%), Positives = 105/304 (34%), Gaps = 50/304 (16%)

Query: 3   ERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQ 62
           +RPAE +++ + S S           E+   A     +K   +         P K  LGQ
Sbjct: 687 QRPAEDSSSSEESDSEE---------EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737

Query: 63  NGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPP 122
                        P    K+ P + +++A    D  +    +  +S   +A  SP     
Sbjct: 738 GTA----------PVLPGKTGPTVTQVKAEKQEDSES----SEEESDSEEAAASPAQVKT 783

Query: 123 STPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRR------FRR 176
           S   +   ++ P+ A            G  +    + + R   K +PP R         R
Sbjct: 784 SVKKTQA-KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 842

Query: 177 SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVR---TLGP 233
             +    +G   A  +  Q G +E+ G     S S+     L+    +G+  +    L P
Sbjct: 843 GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902

Query: 234 AEK---------PPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPES 284
           A++         PP +  PS  +  ++D +   ++  +         DG+ PA     + 
Sbjct: 903 AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDS--------DGEAPAAVTSAQD 954

Query: 285 PQTS 288
            ++S
Sbjct: 955 QESS 958


>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
          Length = 1790

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 87/368 (23%), Positives = 134/368 (36%), Gaps = 55/368 (14%)

Query: 38   PASKPTRRKP-PCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFD 96
            PA+KP    P P + P  PP            PP  +H   ++      + K +      
Sbjct: 1432 PAAKPAVPAPAPVAAPPPPPP-----------PPPGAH--LYEELGDSSMHKYEMPQYGS 1478

Query: 97   PAALLPGASPKSPG-----LKAMVSPFHSPPSTPSSPGVRSR-PSEAEEVPVSFDQPPEG 150
               LLP A  +  G      +         P     P V  R PSE EEV V+ ++PP  
Sbjct: 1479 RRRLLPPAGQEEYGEVVGEAEEEYEEEEEEPKKIKKPKVEIREPSEEEEVVVTIEKPPAA 1538

Query: 151  SHLPCY-------------NKVR----TRGSIKRRPPSRRFRRSQSDCGELGDFRAVESS 193
               P Y              KVR     RG +       + R  + D     D+  +   
Sbjct: 1539 E--PTYTTWKRARIFPMIFKKVRGLADKRGIVDLEGEEWQRRLEEED----KDYLKLTLD 1592

Query: 194  QQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDR 253
            Q+   +     E   S      S   SE +  E       +E P      S T + EE  
Sbjct: 1593 QEEATESTVESEEESSSDYTEYSEEESEFSESETTEEESESETPS-EEEESSTPESEESE 1651

Query: 254  ATEEAKNGEKARRSSEEVDGQHPAQEEVPE-SPQTSGPEAENRCGSPREEKPAGEE---- 308
            +TE    GEKAR++   +  + P  EEV E   +   P+ E +     EE+ + EE    
Sbjct: 1652 STE--SEGEKARKNI-VLARRRPMVEEVKEVKGRKEEPQEEQKEPKMEEEEHSEEEESGP 1708

Query: 309  AEMEKATEVKGERVQNE---EVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQE 365
            A +E++T+ + + +  E   E        E+++  E  +   +  S  GG  G  VP  +
Sbjct: 1709 APVEESTDPEAQDIPEEGSAESASVEGGVESEEESESGSSSSSSESQSGGPWGYQVPAYD 1768

Query: 366  KGKEKQQE 373
            + K   Q+
Sbjct: 1769 RSKNANQK 1776



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 79/328 (24%), Positives = 122/328 (37%), Gaps = 63/328 (19%)

Query: 99   ALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNK 158
            A LP A P  P    + +P   PP  P  PG        +     ++ P  GS       
Sbjct: 1429 AALPAAKPAVPAPAPVAAP---PPPPPPPPGAHLYEELGDSSMHKYEMPQYGS------- 1478

Query: 159  VRTRGSIKRR--PPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGS 216
                   +RR  PP+      Q + GE+      E+ ++   +EE+     P K K P  
Sbjct: 1479 -------RRRLLPPA-----GQEEYGEV----VGEAEEEYEEEEEE-----PKKIKKPKV 1517

Query: 217  PLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEE-------------DRATEEAKNGEK 263
             +       E V T+   EKPP       T K+               D+       GE+
Sbjct: 1518 EIREPSEEEEVVVTI---EKPPAAEPTYTTWKRARIFPMIFKKVRGLADKRGIVDLEGEE 1574

Query: 264  ARRSSEEVDGQHPA----QEEVPESPQTSGPEAENRCGSPREEKPAGEEAE-MEKATEVK 318
             +R  EE D  +      QEE  ES   S  E+ +      EE+    E+E  E+ +E +
Sbjct: 1575 WQRRLEEEDKDYLKLTLDQEEATESTVESEEESSSDYTEYSEEESEFSESETTEEESESE 1634

Query: 319  GERVQNEEVGPEHDSQETKKLEEGAAVKETPHS-------PPGGVKGGDVPKQEKGKEKQ 371
                + E   PE +  E+ + E   A K    +           VKG     QE+ KE +
Sbjct: 1635 TPSEEEESSTPESEESESTESEGEKARKNIVLARRRPMVEEVKEVKGRKEEPQEEQKEPK 1694

Query: 372  QEGAVLEPGCSPQTGPAQLETSSEVQSE 399
             E    E     ++GPA +E S++ +++
Sbjct: 1695 MEEE--EHSEEEESGPAPVEESTDPEAQ 1720


>gi|239757898 PREDICTED: similar to testis expressed sequence 13A
           [Homo sapiens]
          Length = 652

 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 80/318 (25%), Positives = 116/318 (36%), Gaps = 40/318 (12%)

Query: 92  NLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSS-PGVRSRP----SEAEEVPVSFDQ 146
           ++ + P  L P A    P L  +  PF  PP  P   P +   P    + AE   V    
Sbjct: 202 DVLYVPGPLSPWAQGMQPPLP-VPHPFPHPPPFPMKFPSLPPLPPAVVTGAEAAAVPLQM 260

Query: 147 PPEGSHLPC------YNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRA------VESSQ 194
           PP   H PC      + +       +R        +       LGD R+       E SQ
Sbjct: 261 PPTEIHPPCPWPAVGFQEEMAPPWYQRSYIQEEDSKILQGSFPLGDSRSHSQGEGSERSQ 320

Query: 195 QNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRA 254
           +     + G     S+S    +PL S G   +   T GP    PL            +R 
Sbjct: 321 RMPLPGDSGCHNPLSESPQGTAPLGSSGCHSQEEGTEGPQGMDPLG-----------NRE 369

Query: 255 TEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKA 314
            +  K G K  R    +  +   + E PE PQ + P+ ++R  S   ++   + A+ E A
Sbjct: 370 RQNQKEGPKRARRMHTLVFRRSHKSEGPEGPQGTVPQGDSRSYS---QEGCSDRAQ-EMA 425

Query: 315 TEVKGERVQNEEVGPEHDSQETKKLEEGAAVKET-PHSPPGGVKGGD--VPKQEKGKEKQ 371
           T V   R + E  GP+         +  + +KE  P  P   V  GD     QE   E+ 
Sbjct: 426 TLVFIRRCKPE--GPKRPQWTVPLGDSRSHIKEEGPEGPQRIVLQGDNRSYSQEGSPERA 483

Query: 372 QEGA--VLEPGCSPQTGP 387
           Q  A  V    C P+ GP
Sbjct: 484 QGMATLVFSRSCKPEEGP 501



 Score = 32.3 bits (72), Expect = 0.81
 Identities = 90/429 (20%), Positives = 135/429 (31%), Gaps = 75/429 (17%)

Query: 8   TNANVDNSASPSVAQLAGRFREQAAAAKET-PASKPTRRKPPC-----SLPLFPPKVDLG 61
           T+AN        V  + G     A   +   P   P    PP      SLP  PP V  G
Sbjct: 191 THANAQMPTPTDVLYVPGPLSPWAQGMQPPLPVPHPFPHPPPFPMKFPSLPPLPPAVVTG 250

Query: 62  QNGEE---KSPPNASHPP------KFKVKSSPLIEKLQANLTFDPAALLPGASPKS---- 108
                   + PP   HPP       F+ + +P   + ++ +  + + +L G+ P      
Sbjct: 251 AEAAAVPLQMPPTEIHPPCPWPAVGFQEEMAPPWYQ-RSYIQEEDSKILQGSFPLGDSRS 309

Query: 109 ---------------PGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHL 153
                          PG     +P    P   +  G     S+ E         P G+  
Sbjct: 310 HSQGEGSERSQRMPLPGDSGCHNPLSESPQGTAPLGSSGCHSQEEGTEGPQGMDPLGN-- 367

Query: 154 PCYNKVRTRGSIKRRPPSRR------FRRSQSDCGE--------LGDFRAVESSQQNGAK 199
                 R R + K  P   R      FRRS    G          GD R+      +   
Sbjct: 368 ------RERQNQKEGPKRARRMHTLVFRRSHKSEGPEGPQGTVPQGDSRSYSQEGCSDRA 421

Query: 200 EEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAK 259
           +E    V   + K P  P   +     G       E+ P    P R   Q ++R+  +  
Sbjct: 422 QEMATLVFIRRCK-PEGPKRPQWTVPLGDSRSHIKEEGP--EGPQRIVLQGDNRSYSQEG 478

Query: 260 NGEKARRSSEEVDGQHPAQEEVPESPQTS------------GPEAENRCGSPREEKPAGE 307
           + E+A+  +  V  +    EE PE PQ +            GPE   R     + +   +
Sbjct: 479 SPERAQGMATLVFSRSCKPEEGPERPQDTPLGDSRSHIKEEGPEGPQRIVLQGDNRSYSQ 538

Query: 308 EAEMEKA---TEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQ 364
           E   E+A     +   R    E GPE              V+E+P       +    PK 
Sbjct: 539 EGSRERAQGMATLVFSRSCKPEEGPERPQGTPLGDSRSHGVRESPKKWQPQRQKAKKPKV 598

Query: 365 EKGKEKQQE 373
            K    QQ+
Sbjct: 599 NKVSGSQQQ 607


>gi|30795231 brain abundant, membrane attached signal protein 1
           [Homo sapiens]
          Length = 227

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 45/166 (27%), Positives = 72/166 (43%), Gaps = 17/166 (10%)

Query: 260 NGEKARRSSEEVDGQHPAQEEVPES--PQTSGPEAENRCGSPREEKPAGEEAEMEKATEV 317
           N EKA+   ++ +G    +E  P+   PQ +   AE + G   +EKP  ++AE  KA E 
Sbjct: 15  NDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG---KEKP-DQDAE-GKAEEK 69

Query: 318 KGER--VQNEEVGPEHDSQETKKLEEGAAVKETPHSP------PGGVKGGDVPKQEKGKE 369
           +GE+     +E  P+ + ++T+   E  A  E P +P      PG   GG+ PK  +   
Sbjct: 70  EGEKDAAAAKEEAPKAEPEKTEGAAEAKA--EPPKAPEQEQAAPGPAAGGEAPKAAEAAA 127

Query: 370 KQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQDTK 415
              E A    G  P     + + +    +  A     D  P  D+K
Sbjct: 128 APAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSK 173



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 48/213 (22%), Positives = 83/213 (38%), Gaps = 22/213 (10%)

Query: 198 AKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEE 257
           +K++ G  V   K+K       +EGAA E   T  P E  P   +     K+ +++  ++
Sbjct: 6   SKKKKGYNVNDEKAKEKDK--KAEGAATEEEGT--PKESEPQAAAEPAEAKEGKEKPDQD 61

Query: 258 AKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEV 317
           A+        +EE +G+  A     E+P+    + E    +  E   A E+ +       
Sbjct: 62  AEG------KAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAA 115

Query: 318 KGERVQNEEVGPEHDSQETKKLEEGA-AVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAV 376
            GE        P+         E  A A  E P    G  K  + P     +E + +GA 
Sbjct: 116 GGE-------APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAP 168

Query: 377 L---EPGCSPQTGPAQLETSSEVQSEPAVPKPE 406
               +PG S +  P+  ET +  ++  + PK +
Sbjct: 169 ASDSKPG-SSEAAPSSKETPAATEAPSSTPKAQ 200



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 38/183 (20%), Positives = 65/183 (35%), Gaps = 15/183 (8%)

Query: 126 SSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELG 185
           S P   + P+EA+E     DQ  EG           +   K         + ++   E  
Sbjct: 40  SEPQAAAEPAEAKEGKEKPDQDAEG-----------KAEEKEGEKDAAAAKEEAPKAEPE 88

Query: 186 DFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRS--P 243
                  ++    K  + ++  P  +    +P ++E AA         A + P +    P
Sbjct: 89  KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEP 148

Query: 244 SRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQ--TSGPEAENRCGSPRE 301
            +TE      A E   +G  A  S        P+ +E P + +  +S P+A+    S  E
Sbjct: 149 KKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208

Query: 302 EKP 304
            KP
Sbjct: 209 PKP 211



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 37/162 (22%), Positives = 62/162 (38%), Gaps = 21/162 (12%)

Query: 2   EERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKP---PCSLPLFPPKV 58
           EE+  E +A      +P          E AA AK  P   P + +    P +    P   
Sbjct: 67  EEKEGEKDAAAAKEEAPKAEP---EKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123

Query: 59  DLGQNGEEKSPPNASHPP--------KFKVKSSPLIEKLQANLTFDPAA-LLPGASPKSP 109
           +      E + P A   P        K +  ++P  ++ +++    PA+   PG+S  +P
Sbjct: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGA--PASDSKPGSSEAAP 181

Query: 110 GLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGS 151
             K   +   +P STP + G    P+ + E P   + P   S
Sbjct: 182 SSKETPAATEAPSSTPKAQG----PAASAEEPKPVEAPAANS 219


>gi|239752412 PREDICTED: similar to testis expressed sequence 13A
           [Homo sapiens]
          Length = 652

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 77/318 (24%), Positives = 118/318 (37%), Gaps = 40/318 (12%)

Query: 92  NLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSS-PGVRSRP----SEAEEVPVSFDQ 146
           ++ + P  L P A    P L  +  PF  PP  P   P +   P    + AE   V    
Sbjct: 202 DVLYVPGPLSPWAQGMQPPLP-VPHPFPHPPPFPMKFPSLPPLPPAVVTGAEAAAVPLQM 260

Query: 147 PPEGSHLPC-YNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDE 205
           PP   H PC +  V  +  +      R + + +      G F   +S   +  +  +  +
Sbjct: 261 PPTEIHPPCPWPAVGFQEEMAPLWYQRSYIQEEDSKILQGSFPLGDSRSHSQGEGSERSQ 320

Query: 206 VLP-----------SKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRA 254
            +P           S+S    +PL S G   +   T GP    PL            +R 
Sbjct: 321 RMPLPGDSGCHNPLSESPQGTAPLGSSGCHSQEEGTEGPQGMDPLG-----------NRE 369

Query: 255 TEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKA 314
            +  K G K  R    +  +   + E PE PQ + P+ ++R  S   ++   + A+ E A
Sbjct: 370 RQNQKEGPKRARRMHTLVFRRSHKSEGPEGPQGTVPQGDSRSYS---QEGCSDRAQ-EMA 425

Query: 315 TEVKGERVQNEEVGPEHDSQETKKLEEGAAVKET-PHSPPGGVKGGD--VPKQEKGKEKQ 371
           T V   R + E  GP+         +  + +KE  P  P   V  GD     QE   E+ 
Sbjct: 426 TLVFIRRCKPE--GPKRPQWTVPLGDSRSHIKEEGPEGPQRIVLQGDNRSYSQEGSPERA 483

Query: 372 QEGA--VLEPGCSPQTGP 387
           Q  A  V    C P+ GP
Sbjct: 484 QGMATLVFSRSCKPEEGP 501



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 91/429 (21%), Positives = 136/429 (31%), Gaps = 75/429 (17%)

Query: 8   TNANVDNSASPSVAQLAGRFREQAAAAKET-PASKPTRRKPPC-----SLPLFPPKVDLG 61
           T+AN        V  + G     A   +   P   P    PP      SLP  PP V  G
Sbjct: 191 THANAQMPTPTDVLYVPGPLSPWAQGMQPPLPVPHPFPHPPPFPMKFPSLPPLPPAVVTG 250

Query: 62  QNGEE---KSPPNASHPP------KFKVKSSPLIEKLQANLTFDPAALLPGASPKS---- 108
                   + PP   HPP       F+ + +PL  + ++ +  + + +L G+ P      
Sbjct: 251 AEAAAVPLQMPPTEIHPPCPWPAVGFQEEMAPLWYQ-RSYIQEEDSKILQGSFPLGDSRS 309

Query: 109 ---------------PGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHL 153
                          PG     +P    P   +  G     S+ E         P G+  
Sbjct: 310 HSQGEGSERSQRMPLPGDSGCHNPLSESPQGTAPLGSSGCHSQEEGTEGPQGMDPLGN-- 367

Query: 154 PCYNKVRTRGSIKRRPPSRR------FRRSQSDCGE--------LGDFRAVESSQQNGAK 199
                 R R + K  P   R      FRRS    G          GD R+      +   
Sbjct: 368 ------RERQNQKEGPKRARRMHTLVFRRSHKSEGPEGPQGTVPQGDSRSYSQEGCSDRA 421

Query: 200 EEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAK 259
           +E    V   + K P  P   +     G       E+ P    P R   Q ++R+  +  
Sbjct: 422 QEMATLVFIRRCK-PEGPKRPQWTVPLGDSRSHIKEEGP--EGPQRIVLQGDNRSYSQEG 478

Query: 260 NGEKARRSSEEVDGQHPAQEEVPESPQTS------------GPEAENRCGSPREEKPAGE 307
           + E+A+  +  V  +    EE PE PQ +            GPE   R     + +   +
Sbjct: 479 SPERAQGMATLVFSRSCKPEEGPERPQDTPLGDSRSHIKEEGPEGPQRIVLQGDNRSYSQ 538

Query: 308 EAEMEKA---TEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQ 364
           E   E+A     +   R    E GPE              V+E+P       +    PK 
Sbjct: 539 EGSRERAQGMATLVFSRSCKPEEGPERPQGTPLGDSRSHGVRESPKKWQPQRQKAKKPKV 598

Query: 365 EKGKEKQQE 373
            K    QQ+
Sbjct: 599 NKVSGSQQQ 607


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.302    0.124    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,081,997
Number of Sequences: 37866
Number of extensions: 1359114
Number of successful extensions: 10348
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 220
Number of HSP's successfully gapped in prelim test: 1219
Number of HSP's that attempted gapping in prelim test: 6878
Number of HSP's gapped (non-prelim): 3519
length of query: 416
length of database: 18,247,518
effective HSP length: 105
effective length of query: 311
effective length of database: 14,271,588
effective search space: 4438463868
effective search space used: 4438463868
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.