Guide to the Human Genome
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Search of human proteins with 217035102

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|217035102 pre-mRNA cleavage factor I, 59 kDa subunit isoform
1 [Homo sapiens]
         (514 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|217035102 pre-mRNA cleavage factor I, 59 kDa subunit isoform ...  1049   0.0  
gi|209862881 pre-mRNA cleavage factor I, 59 kDa subunit isoform ...   964   0.0  
gi|217035107 pre-mRNA cleavage factor I, 59 kDa subunit isoform ...   937   0.0  
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ...   397   e-110
gi|150417989 cyclin K isoform 1 [Homo sapiens]                         77   5e-14
gi|11386183 WAS protein family, member 2 [Homo sapiens]                73   5e-13
gi|160707881 formin 2 [Homo sapiens]                                   72   1e-12
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                     69   8e-12
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                     69   8e-12
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap...    68   2e-11
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]                     65   2e-10
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]                     65   2e-10
gi|210032580 SET domain containing 1B [Homo sapiens]                   65   2e-10
gi|157168329 formin 1 [Homo sapiens]                                   64   3e-10
gi|201023339 FIP1 like 1 isoform 2 [Homo sapiens]                      64   3e-10
gi|91208418 transcription elongation regulator 1 isoform 2 [Homo...    64   3e-10
gi|21327715 transcription elongation regulator 1 isoform 1 [Homo...    64   3e-10
gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]                63   6e-10
gi|56549694 enabled homolog isoform a [Homo sapiens]                   63   7e-10
gi|39930375 enabled homolog isoform b [Homo sapiens]                   63   7e-10
gi|33356148 formin-like 1 [Homo sapiens]                               62   2e-09
gi|56118221 amyloid beta (A4) precursor protein-binding, family ...    61   2e-09
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]             60   4e-09
gi|19923345 RNA binding motif protein 12 [Homo sapiens]                60   4e-09
gi|23510462 RNA binding motif protein 12 [Homo sapiens]                60   4e-09
gi|153792074 proline rich 12 [Homo sapiens]                            60   5e-09
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    60   6e-09
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap...    59   8e-09
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]                59   1e-08
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]                59   1e-08

>gi|217035102 pre-mRNA cleavage factor I, 59 kDa subunit isoform 1
           [Homo sapiens]
          Length = 514

 Score = 1049 bits (2713), Expect = 0.0
 Identities = 514/514 (100%), Positives = 514/514 (100%)

Query: 1   MGRPESAGGGSRGPFEGGGRARRAGGIFLTLSILRTRDLPSGAMSEGVDLIDIYADEEFN 60
           MGRPESAGGGSRGPFEGGGRARRAGGIFLTLSILRTRDLPSGAMSEGVDLIDIYADEEFN
Sbjct: 1   MGRPESAGGGSRGPFEGGGRARRAGGIFLTLSILRTRDLPSGAMSEGVDLIDIYADEEFN 60

Query: 61  QDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGL 120
           QDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGL
Sbjct: 61  QDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGL 120

Query: 121 RNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENS 180
           RNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENS
Sbjct: 121 RNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENS 180

Query: 181 VHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDS 240
           VHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDS
Sbjct: 181 VHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDS 240

Query: 241 ADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPP 300
           ADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPP
Sbjct: 241 ADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPP 300

Query: 301 PPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPY 360
           PPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPY
Sbjct: 301 PPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPY 360

Query: 361 NHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAV 420
           NHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAV
Sbjct: 361 NHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAV 420

Query: 421 IKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRR 480
           IKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRR
Sbjct: 421 IKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRR 480

Query: 481 HRDLLHNEDRHDDYFQERNREHERHRDRERDRHH 514
           HRDLLHNEDRHDDYFQERNREHERHRDRERDRHH
Sbjct: 481 HRDLLHNEDRHDDYFQERNREHERHRDRERDRHH 514


>gi|209862881 pre-mRNA cleavage factor I, 59 kDa subunit isoform 2
           [Homo sapiens]
          Length = 471

 Score =  964 bits (2492), Expect = 0.0
 Identities = 471/471 (100%), Positives = 471/471 (100%)

Query: 44  MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPS 103
           MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPS
Sbjct: 1   MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPS 60

Query: 104 PKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRA 163
           PKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRA
Sbjct: 61  PKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRA 120

Query: 164 NGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRV 223
           NGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRV
Sbjct: 121 NGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRV 180

Query: 224 PRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPP 283
           PRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPP
Sbjct: 181 PRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPP 240

Query: 284 PIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPN 343
           PIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPN
Sbjct: 241 PIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPN 300

Query: 344 ATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGAS 403
           ATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGAS
Sbjct: 301 ATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGAS 360

Query: 404 AGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKR 463
           AGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKR
Sbjct: 361 AGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKR 420

Query: 464 HRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH 514
           HRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH
Sbjct: 421 HRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH 471


>gi|217035107 pre-mRNA cleavage factor I, 59 kDa subunit isoform 3
           [Homo sapiens]
          Length = 462

 Score =  937 bits (2421), Expect = 0.0
 Identities = 462/471 (98%), Positives = 462/471 (98%), Gaps = 9/471 (1%)

Query: 44  MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPS 103
           MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPS
Sbjct: 1   MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPS 60

Query: 104 PKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRA 163
           PKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRA
Sbjct: 61  PKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRA 120

Query: 164 NGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRV 223
           NGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKR     
Sbjct: 121 NGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKR----- 175

Query: 224 PRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPP 283
               IPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPP
Sbjct: 176 ----IPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPP 231

Query: 284 PIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPN 343
           PIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPN
Sbjct: 232 PIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPN 291

Query: 344 ATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGAS 403
           ATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGAS
Sbjct: 292 ATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGAS 351

Query: 404 AGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKR 463
           AGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKR
Sbjct: 352 AGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKR 411

Query: 464 HRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH 514
           HRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH
Sbjct: 412 HRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH 462


>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
           subunit [Homo sapiens]
          Length = 551

 Score =  397 bits (1019), Expect = e-110
 Identities = 255/557 (45%), Positives = 314/557 (56%), Gaps = 107/557 (19%)

Query: 44  MSEGVDLIDIYAD--EEFNQDPEFNNTDQIDLYDDVLTATSQPSD---DRSSSTEPPPPV 98
           M++GVD IDIYAD  EEFNQ+ E+   DQIDLYDDV++ ++   D   DR      PP V
Sbjct: 1   MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYMDTLPPTV 60

Query: 99  RQEPSPKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKF 158
             +         P ++YTY+G   +R A+Y+G+ +WWTTD+ L + + S+GV D++E+KF
Sbjct: 61  GDDVG---KGAAPNVVYTYTG---KRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKF 114

Query: 159 AENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKR 218
            ENRANGQSKG+A V V SE S  KL++LLP + L+G+   V P  +Q LSQFE Q+RK 
Sbjct: 115 FENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKT 174

Query: 219 ECVRVPRG---GIPPRAHSRDS-SDSADGR-----ATPSENLVPSSARVDKPPSVLPYFN 269
                  G     PP   SR +      GR     A P  +  P  A    PP   P   
Sbjct: 175 TQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQ 234

Query: 270 RPPSALPLMGLPPPPIPP---------PPPLSSS-----------------FGVPP---- 299
            PP   P +G P PP PP         PPPL+                   FG PP    
Sbjct: 235 TPPR--PPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPL 292

Query: 300 ------------PPPGIHYQHLMPPPP------------------RLPPHLAVPPPGAIP 329
                       PPPG       PPPP                    PPHL  PPPGA P
Sbjct: 293 PPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPP 352

Query: 330 PALHLNPAFFPPP-------NATVGPPPDTYMKASAPYNHHGSRDSGPPP-------STV 375
           PA H+NPAFFPPP       + + GPPP        PY+     D GPP        + +
Sbjct: 353 PAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRG---DYGPPGREMDTARTPL 409

Query: 376 SEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVL 435
           SEAEFE+IM RNRAISSSAIS+AVS ASAGDY  AIETL+TAI++IKQS+V+ D+RC+VL
Sbjct: 410 SEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVL 469

Query: 436 ISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYF 495
           ISSL+DCLHGIE+KSY     GS SR R RSRER  SRSRE SRRH+    + DRHDDY+
Sbjct: 470 ISSLQDCLHGIESKSY-----GSGSR-RERSRERDHSRSREKSRRHKS--RSRDRHDDYY 521

Query: 496 QERNREHERHRDRERDR 512
           +ER+RE ERHRDR+RDR
Sbjct: 522 RERSRERERHRDRDRDR 538


>gi|150417989 cyclin K isoform 1 [Homo sapiens]
          Length = 580

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 47/103 (45%), Positives = 51/103 (49%), Gaps = 21/103 (20%)

Query: 261 PPSVLPYFNR--------PPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPP 312
           PP+ LPY           PP   P    PPP IPPP P     G PPPPP  +  +  PP
Sbjct: 467 PPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTP-----GYPPPPP-TYNPNFPPP 520

Query: 313 PPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVG-----PPP 350
           PPRLPP  AVPP    PP L L PA +PPP    G     PPP
Sbjct: 521 PPRLPPTHAVPPHP--PPGLGLPPASYPPPAVPPGGQPPVPPP 561



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 49/158 (31%), Positives = 64/158 (40%), Gaps = 34/158 (21%)

Query: 229 PPRAHSRDSSDSADGRATPSENLVPSSARVDKPP-SVLPYFNRPPSALPLMGLPPPPIPP 287
           PP ++    S ++   +      + S  + + P    LP    PP+ LP      PP PP
Sbjct: 424 PPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPP 483

Query: 288 PPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPP----- 342
           PPP      VPPPP          PPP +PP    P PG  PP    NP F PPP     
Sbjct: 484 PPP------VPPPPASF-------PPPAIPP----PTPGYPPPPPTYNPNFPPPPPRLPP 526

Query: 343 -NAT-------VGPPPDTYMKASAPYNHHGSRDSGPPP 372
            +A        +G PP +Y   + P    G +   PPP
Sbjct: 527 THAVPPHPPPGLGLPPASYPPPAVP---PGGQPPVPPP 561



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 35/80 (43%), Positives = 40/80 (50%), Gaps = 10/80 (12%)

Query: 261 PPSVLPYFNRPPSALP--LMGLPPPP------IPPPPP-LSSSFGVPP-PPPGIHYQHLM 310
           PP   P  + PP A+P    G PPPP       PPPPP L  +  VPP PPPG+      
Sbjct: 485 PPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPAS 544

Query: 311 PPPPRLPPHLAVPPPGAIPP 330
            PPP +PP    P P  IPP
Sbjct: 545 YPPPAVPPGGQPPVPPPIPP 564



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 43/126 (34%), Positives = 49/126 (38%), Gaps = 45/126 (35%)

Query: 265 LPYFNRPPSALPLMGLPPPPIP---PPPPLSS---------------------------- 293
           LP    PP A P     PPP+P   PPPP SS                            
Sbjct: 396 LPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEG 455

Query: 294 -SFGVPPP---PPGI--HYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVG 347
            S+G  PP   PP    ++ H+ PP P  PP    PPP + PP     PA  PPP     
Sbjct: 456 PSYGALPPAYGPPAHLPYHPHVYPPNPPPPP--VPPPPASFPP-----PAI-PPPTPGYP 507

Query: 348 PPPDTY 353
           PPP TY
Sbjct: 508 PPPPTY 513



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 31/85 (36%), Positives = 34/85 (40%), Gaps = 21/85 (24%)

Query: 286 PPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLA----VPPPG----------AIPPA 331
           PPPP +       PP P  H     PPP R PP  A      PPG           IPP 
Sbjct: 350 PPPPKIPKIETTHPPLPPAH-----PPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPP 404

Query: 332 LHLNPAFFPP--PNATVGPPPDTYM 354
            H  P   PP  P+    PPP +YM
Sbjct: 405 AHPAPVHQPPPLPHRPPPPPPSSYM 429



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 28/79 (35%), Positives = 36/79 (45%), Gaps = 10/79 (12%)

Query: 253 PSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPP---PPPGIHYQHL 309
           P+      PP+  P F  PP  LP    P   +PP PP     G+PP   PPP +     
Sbjct: 502 PTPGYPPPPPTYNPNFPPPPPRLP----PTHAVPPHPP--PGLGLPPASYPPPAVPPGGQ 555

Query: 310 MPPPPRLPPHLAVPPPGAI 328
            P PP +PP   +PP G +
Sbjct: 556 PPVPPPIPPP-GMPPVGGL 573



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 24/66 (36%), Positives = 28/66 (42%), Gaps = 16/66 (24%)

Query: 247 PSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHY 306
           P   L P+ A    PP   P    PP++ P   +PP   PP PP       P PPPG   
Sbjct: 520 PPPRLPPTHAVPPHPP---PGLGLPPASYPPPAVPPGGQPPVPP-------PIPPPG--- 566

Query: 307 QHLMPP 312
              MPP
Sbjct: 567 ---MPP 569


>gi|11386183 WAS protein family, member 2 [Homo sapiens]
          Length = 498

 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 67/211 (31%), Positives = 84/211 (39%), Gaps = 30/211 (14%)

Query: 229 PPRAHSRDSSDS--ADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIP 286
           PP A      D+    G A P  + V S +     P   P    PP   P    PP P P
Sbjct: 269 PPPAEFSYPVDNQRGSGLAGPKRSSVVSPSH----PPPAPPLGSPPGPKPGFAPPPAPPP 324

Query: 287 PPPPLSSSFGVPPPPPGIHY----QHLMPPPPRLPPH--LAVPPPGAIPPALHLNPAFFP 340
           PPPP+    G+PPPPP + +        P PP  PPH   A PPP   PPA     A +P
Sbjct: 325 PPPPM---IGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPA-----ADYP 376

Query: 341 PPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVS 400
               T+ PPP +     AP         GPPP   + A+ +       AI          
Sbjct: 377 ----TLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQP------AIPPPLSDTTKP 426

Query: 401 GASAGDYSDAIETLLTAIAVIKQSRVANDER 431
            +S    SDA   LL+AI    Q R   ++R
Sbjct: 427 KSSLPAVSDARSDLLSAIRQGFQLRRVEEQR 457



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 35/110 (31%), Positives = 39/110 (35%), Gaps = 22/110 (20%)

Query: 287 PPPPLSSSFGVPPPPPGIHYQHLMPPPPRL--------------PPHLAVPPPGAIPPAL 332
           PPPP S S     P P     +L PPP                 P   +V  P   PPA 
Sbjct: 247 PPPPQSDS--ASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHPPPAP 304

Query: 333 HL------NPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVS 376
            L       P F PPP     PPP   +    P    GS  + PPPS  S
Sbjct: 305 PLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPS 354


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 54/143 (37%), Positives = 66/143 (46%), Gaps = 27/143 (18%)

Query: 223  VPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPP 282
            +P  GIPP            G   P    +P  A +  PP +      PP  LP +G+PP
Sbjct: 1102 LPGVGIPP-------PPPLPGAGIPPPPPLPG-AGIPPPPPLPGAGIPPPPPLPRVGIPP 1153

Query: 283  PP------IPPPPPLSSSFGVPPPPP--GIHYQHLMPPPPRLPPHLAVPPP-----GAIP 329
            PP      IPPPPPL  + G+PPPPP  G+     +PPPP LP  + +PPP       IP
Sbjct: 1154 PPPLPGAGIPPPPPLPGA-GIPPPPPLPGVG----IPPPPPLPG-VGIPPPPPLPGAGIP 1207

Query: 330  PALHLNPAFFPPPNATVGPPPDT 352
            P   L     PP  A   PPP T
Sbjct: 1208 PPPPLPGMGIPPAPAPPLPPPGT 1230



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 56/151 (37%), Positives = 63/151 (41%), Gaps = 26/151 (17%)

Query: 223  VPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPP 282
            +P  GIPP            G A P    +P  A +  PP +      PP  LP  G+PP
Sbjct: 937  LPGAGIPP-------PPPLPGAAIPPPPPLPG-AGIPLPPPLPGAGIPPPPPLPGAGIPP 988

Query: 283  PP------IPPPPPL-SSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPP----GAIPPA 331
            PP      IPPPPPL  +    PPP PG      +PPPP LP     PPP      IPP 
Sbjct: 989  PPPLPGAGIPPPPPLPGAGIPPPPPLPGAG----IPPPPPLPGAGIPPPPPLPGAGIPPP 1044

Query: 332  LHLNPAFFPPPNATVG---PPPDTYMKASAP 359
              L  A  PPP    G   PPP     A  P
Sbjct: 1045 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1075



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 59/177 (33%), Positives = 70/177 (39%), Gaps = 39/177 (22%)

Query: 223  VPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPP 282
            +P  GIPP            G   P    +P  A +  PP +      PP  LP  G+PP
Sbjct: 1047 LPGAGIPP-------PPPLPGAGIPPPPPLPG-AGIPPPPPLPGAGIPPPPPLPGAGIPP 1098

Query: 283  PP------IPPPPPL-SSSFGVPPPPPGIHYQHLMPPPPRLP----------PHLAVPPP 325
            PP      IPPPPPL  +    PPP PG      +PPPP LP          P + +PPP
Sbjct: 1099 PPPLPGVGIPPPPPLPGAGIPPPPPLPGAG----IPPPPPLPGAGIPPPPPLPRVGIPPP 1154

Query: 326  -----GAIPPALHLNPAFFPPPNATVG-----PPPDTYMKASAPYNHHGSRDSGPPP 372
                   IPP   L  A  PPP    G     PPP   +    P    G+    PPP
Sbjct: 1155 PPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPP 1211



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 52/143 (36%), Positives = 61/143 (42%), Gaps = 27/143 (18%)

Query: 223  VPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPP 282
            +P  GIPP            G   P    +P  A +  PP +      PP  LP  G+PP
Sbjct: 1025 LPGAGIPP-------PPPLPGAGIPPPPPLPG-AGIPPPPPLPGAGIPPPPPLPGAGIPP 1076

Query: 283  PP------IPPPPPL-SSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPP----GAIPPA 331
            PP      IPPPPPL  +    PPP PG+     +PPPP LP     PPP      IPP 
Sbjct: 1077 PPPLPGAGIPPPPPLPGAGIPPPPPLPGVG----IPPPPPLPGAGIPPPPPLPGAGIPPP 1132

Query: 332  LHLNPAFFPP----PNATVGPPP 350
              L  A  PP    P   + PPP
Sbjct: 1133 PPLPGAGIPPPPPLPRVGIPPPP 1155



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 48/114 (42%), Positives = 51/114 (44%), Gaps = 19/114 (16%)

Query: 261  PPSVLPYFN-RPPSALPLMGLPPPP------IPPPPPL-SSSFGVPPPPPGIHYQHLMPP 312
            PP  LP     PP  LP  G+PPPP      IPPPPPL  +    PPP PG      +PP
Sbjct: 988  PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG----IPP 1043

Query: 313  PPRLPPHLAVPPP----GAIPPALHLNPAFFPPPNATVG---PPPDTYMKASAP 359
            PP LP     PPP      IPP   L  A  PPP    G   PPP     A  P
Sbjct: 1044 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1097



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 47/114 (41%), Positives = 51/114 (44%), Gaps = 19/114 (16%)

Query: 261  PPSVLPYFN-RPPSALPLMGLPPPP------IPPPPPL-SSSFGVPPPPPGIHYQHLMPP 312
            PP  LP     P   LP  G+PPPP      IPPPPPL  +   +PPP PG      +PP
Sbjct: 922  PPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAG----IPP 977

Query: 313  PPRLPPHLAVPPP----GAIPPALHLNPAFFPPPNATVG---PPPDTYMKASAP 359
            PP LP     PPP      IPP   L  A  PPP    G   PPP     A  P
Sbjct: 978  PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1031



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 53/155 (34%), Positives = 61/155 (39%), Gaps = 34/155 (21%)

Query: 223  VPRGGIPPRAHSRDSSDSADGRATPSENLVP----SSARVDKPPSVLPYFNRPPSALPLM 278
            +P  GIPP                P   ++P      A +  PP +      PP  LP  
Sbjct: 915  LPGAGIPPPP------------PLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGA 962

Query: 279  GLPPPP------IPPPPPL-SSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPP----GA 327
            G+P PP      IPPPPPL  +    PPP PG      +PPPP LP     PPP      
Sbjct: 963  GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG----IPPPPPLPGAGIPPPPPLPGAG 1018

Query: 328  IPPALHLNPAFFPPPNATVG---PPPDTYMKASAP 359
            IPP   L  A  PPP    G   PPP     A  P
Sbjct: 1019 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1053



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 51/136 (37%), Positives = 59/136 (43%), Gaps = 17/136 (12%)

Query: 246 TPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIH 305
           T S + +P    V  PP  LP    P        LP   IP PPPL  +  +PPPPP + 
Sbjct: 864 TESSSSMPGLGMVPPPPPPLPGMTVPT-------LPSTAIPQPPPLQGTEMLPPPPPPLP 916

Query: 306 YQHLMPPPPRLPPH--LAVPP-PGA-IPPALHLNPAFFPPPNATVG-----PPPDTYMKA 356
              + PPPP LP    L +PP PGA IPP   L  A  PPP    G     PPP      
Sbjct: 917 GAGI-PPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI 975

Query: 357 SAPYNHHGSRDSGPPP 372
             P    G+    PPP
Sbjct: 976 PPPPPLPGAGIPPPPP 991



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 34/80 (42%), Positives = 40/80 (50%), Gaps = 17/80 (21%)

Query: 261  PPSVLPYFN-RPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMP--PPPRLP 317
            PP  LP     PP  LP MG+PP P PP PP  +  G+PPPP       L+P   PP LP
Sbjct: 1197 PPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGT--GIPPPP-------LLPVSGPPLLP 1247

Query: 318  P--HLAVPPP---GAIPPAL 332
                  +P P   G +PP L
Sbjct: 1248 QVGSSTLPTPQVCGFLPPPL 1267



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 38/128 (29%), Positives = 48/128 (37%), Gaps = 27/128 (21%)

Query: 223  VPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPP 282
            +P  GIPP            G   P    +P    +  PP +      PP  LP  G   
Sbjct: 1157 LPGAGIPP-------PPPLPGAGIPPPPPLPGVG-IPPPPPLPGVGIPPPPPLPGAG--- 1205

Query: 283  PPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPP 342
              IPPPPPL    G+PP           P PP  PP   +PPP  +P +    P   P  
Sbjct: 1206 --IPPPPPL-PGMGIPP----------APAPPLPPPGTGIPPPPLLPVS---GPPLLPQV 1249

Query: 343  NATVGPPP 350
             ++  P P
Sbjct: 1250 GSSTLPTP 1257


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 43/102 (42%), Positives = 50/102 (49%), Gaps = 15/102 (14%)

Query: 261 PPSVLPYFNRPPSALPLMG----LPPPPIP-------PPPPLSSSFGVPPPPPGIHYQHL 309
           PP  LP     PS   L G     PPPP+P       PPPPL  S G+PPPPP +  +  
Sbjct: 644 PPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAG 703

Query: 310 MPP-PPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPP 350
           MPP PP LP    +PPP   P    + P   PPP   + PPP
Sbjct: 704 MPPPPPPLPGGPGIPPPPPFPGGPGIPP---PPPGMGMPPPP 742



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 38/101 (37%), Positives = 49/101 (48%), Gaps = 7/101 (6%)

Query: 242 DGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPP 301
           +G   PS + +P    +  PP +      PP   PL G    P PPPPPL    G+PPPP
Sbjct: 650 EGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIP-PPPPPLPGEAGMPPPP 708

Query: 302 PGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPP 342
           P +     +PPPP  P    +PPP   PP + + P   PPP
Sbjct: 709 PPLPGGPGIPPPPPFPGGPGIPPP---PPGMGMPP---PPP 743



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 44/166 (26%), Positives = 64/166 (38%), Gaps = 18/166 (10%)

Query: 196 EKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSS 255
           EK D+     Q   +     ++ E  +     +   A +   S  +     P+  L   S
Sbjct: 524 EKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDS 583

Query: 256 ARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGV--PP---------PPPGI 304
             +  PP        PP        PPPP PPPPPL     +  PP         PPP +
Sbjct: 584 GTIIPPPPAPGDSTTPPP-------PPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPL 636

Query: 305 HYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPP 350
                +PPPP LP  + +P P ++P    + P    P +A + PPP
Sbjct: 637 SGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPP 682



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 45/147 (30%), Positives = 59/147 (40%), Gaps = 38/147 (25%)

Query: 228 IPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIP- 286
           +PP   SR           P    +P  +    PP   P  +  P   P    PPPP+P 
Sbjct: 563 VPPSVPSR--------APVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPG 614

Query: 287 -----------------PPPPLSSSFGVPPPPP---GIHYQHLMPPPPRLPPHLAVPPPG 326
                            PPPPLS    +PPPPP   G+     +P P  LP   A+PPP 
Sbjct: 615 GVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVG----IPSPSSLPGGTAIPPPP 670

Query: 327 AIPPALHLNPAFFPPP---NATVGPPP 350
            +P +  + P   PPP   +A + PPP
Sbjct: 671 PLPGSARIPPP--PPPLPGSAGIPPPP 695



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 34/85 (40%), Positives = 40/85 (47%), Gaps = 17/85 (20%)

Query: 244 RATPSENLVPSSARVDKPPSVLP-YFNRPPSALPLMG---LPPPP-------IPPPPPLS 292
           R  P    +P SA +  PP  LP     PP   PL G   +PPPP       IPPPPP  
Sbjct: 677 RIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPP-- 734

Query: 293 SSFGVPPPPPGIHYQHLMPPPPRLP 317
              G+PPPPP   +   +P  P LP
Sbjct: 735 -GMGMPPPPP---FGFGVPAAPVLP 755



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 37/111 (33%), Positives = 41/111 (36%), Gaps = 38/111 (34%)

Query: 223 VPRG-GIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPY---FNRPPSALP-L 277
           +P G GIP        S    G A P    +P SAR+  PP  LP       PP  LP  
Sbjct: 648 LPEGVGIP------SPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGE 701

Query: 278 MGLPPPP--------IPPPPPLSS-------------------SFGVPPPP 301
            G+PPPP        IPPPPP                       FGVP  P
Sbjct: 702 AGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP 752



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 29/102 (28%), Positives = 36/102 (35%), Gaps = 14/102 (13%)

Query: 277 LMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNP 336
           +  L    I  PP + S   VPP PP       + PPP  P     PPP           
Sbjct: 553 MASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPP----------- 601

Query: 337 AFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEA 378
              PPP     PP    +  S+P +  G     PPP    +A
Sbjct: 602 ---PPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDA 640


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 43/102 (42%), Positives = 50/102 (49%), Gaps = 15/102 (14%)

Query: 261 PPSVLPYFNRPPSALPLMG----LPPPPIP-------PPPPLSSSFGVPPPPPGIHYQHL 309
           PP  LP     PS   L G     PPPP+P       PPPPL  S G+PPPPP +  +  
Sbjct: 653 PPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAG 712

Query: 310 MPP-PPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPP 350
           MPP PP LP    +PPP   P    + P   PPP   + PPP
Sbjct: 713 MPPPPPPLPGGPGIPPPPPFPGGPGIPP---PPPGMGMPPPP 751



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 38/101 (37%), Positives = 49/101 (48%), Gaps = 7/101 (6%)

Query: 242 DGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPP 301
           +G   PS + +P    +  PP +      PP   PL G    P PPPPPL    G+PPPP
Sbjct: 659 EGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIP-PPPPPLPGEAGMPPPP 717

Query: 302 PGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPP 342
           P +     +PPPP  P    +PPP   PP + + P   PPP
Sbjct: 718 PPLPGGPGIPPPPPFPGGPGIPPP---PPGMGMPP---PPP 752



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 44/166 (26%), Positives = 64/166 (38%), Gaps = 18/166 (10%)

Query: 196 EKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSS 255
           EK D+     Q   +     ++ E  +     +   A +   S  +     P+  L   S
Sbjct: 533 EKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDS 592

Query: 256 ARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGV--PP---------PPPGI 304
             +  PP        PP        PPPP PPPPPL     +  PP         PPP +
Sbjct: 593 GTIIPPPPAPGDSTTPPP-------PPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPL 645

Query: 305 HYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPP 350
                +PPPP LP  + +P P ++P    + P    P +A + PPP
Sbjct: 646 SGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPP 691



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 45/147 (30%), Positives = 59/147 (40%), Gaps = 38/147 (25%)

Query: 228 IPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIP- 286
           +PP   SR           P    +P  +    PP   P  +  P   P    PPPP+P 
Sbjct: 572 VPPSVPSR--------APVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPG 623

Query: 287 -----------------PPPPLSSSFGVPPPPP---GIHYQHLMPPPPRLPPHLAVPPPG 326
                            PPPPLS    +PPPPP   G+     +P P  LP   A+PPP 
Sbjct: 624 GVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVG----IPSPSSLPGGTAIPPPP 679

Query: 327 AIPPALHLNPAFFPPP---NATVGPPP 350
            +P +  + P   PPP   +A + PPP
Sbjct: 680 PLPGSARIPPP--PPPLPGSAGIPPPP 704



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 34/85 (40%), Positives = 40/85 (47%), Gaps = 17/85 (20%)

Query: 244 RATPSENLVPSSARVDKPPSVLP-YFNRPPSALPLMG---LPPPP-------IPPPPPLS 292
           R  P    +P SA +  PP  LP     PP   PL G   +PPPP       IPPPPP  
Sbjct: 686 RIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPP-- 743

Query: 293 SSFGVPPPPPGIHYQHLMPPPPRLP 317
              G+PPPPP   +   +P  P LP
Sbjct: 744 -GMGMPPPPP---FGFGVPAAPVLP 764



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 37/111 (33%), Positives = 41/111 (36%), Gaps = 38/111 (34%)

Query: 223 VPRG-GIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPY---FNRPPSALP-L 277
           +P G GIP        S    G A P    +P SAR+  PP  LP       PP  LP  
Sbjct: 657 LPEGVGIP------SPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGE 710

Query: 278 MGLPPPP--------IPPPPPLSS-------------------SFGVPPPP 301
            G+PPPP        IPPPPP                       FGVP  P
Sbjct: 711 AGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP 761



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 29/102 (28%), Positives = 36/102 (35%), Gaps = 14/102 (13%)

Query: 277 LMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNP 336
           +  L    I  PP + S   VPP PP       + PPP  P     PPP           
Sbjct: 562 MASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPP----------- 610

Query: 337 AFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEA 378
              PPP     PP    +  S+P +  G     PPP    +A
Sbjct: 611 ---PPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDA 649


>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
           sapiens]
          Length = 505

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 59/199 (29%), Positives = 78/199 (39%), Gaps = 26/199 (13%)

Query: 212 EAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRP 271
           EAQ + RE  +V    I          +    +A P     P  +R   PP   P  N  
Sbjct: 243 EAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPP----PPPSRGGPPPPPPPPHNSG 298

Query: 272 PSALPLMGL---PPPPI-------PPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLA 321
           P   P  G    PPPP        PPPPP   S  VPPPPP   Y    PPPP LP    
Sbjct: 299 PPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYP---PPPPALPSSAP 355

Query: 322 VPPPGAIPPALHLNPAFFPPPNAT---VGPPPDTYMKASAPYNHHGSRDSGPPPSTVSE- 377
             PP   P  L + P   PPP       GPPP   + +    +H     +G   + + + 
Sbjct: 356 SGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDG--DHQVPTTAGNKAALLDQI 413

Query: 378 ---AEFEDIMKRNRAISSS 393
              A+ + + + +R +S S
Sbjct: 414 REGAQLKKVEQNSRPVSCS 432


>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
          Length = 1096

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 34/80 (42%), Positives = 39/80 (48%), Gaps = 14/80 (17%)

Query: 271 PPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPP 330
           PP+A PL G+ PPP PP PPL     +PPPPP +     +PPPP  P     PPP     
Sbjct: 551 PPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPP----- 605

Query: 331 ALHLNPAFFPPPNATVGPPP 350
                    PPP   V PPP
Sbjct: 606 ---------PPPLGGVPPPP 616



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 35/85 (41%), Positives = 40/85 (47%), Gaps = 10/85 (11%)

Query: 279 GLPPPPIPPPPPLSSSFGVPPPPPGIHY---QHLMPPPPRLPPHLAVPPPGAIPPALHLN 335
           G+P PP  PP P     G PPPPP         L PPPP LP  + +PPP   PP L   
Sbjct: 547 GIPGPPAAPPLP---GVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPP-PPLLFGG 602

Query: 336 PAFFPPPNATVGPPPDTYMKASAPY 360
           P   PPP    G PP   +  + PY
Sbjct: 603 P---PPPPPLGGVPPPPGISLNLPY 624



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 37/92 (40%), Positives = 45/92 (48%), Gaps = 18/92 (19%)

Query: 251 LVPSSARVDKPPSVLPYFN----RPPSALPLMG---LPPPPIPPPPPLSSSFGVPPPPPG 303
           ++ SS+ +  PP+  P        PP A PL G   LPPPP PP P +    G+PPPPP 
Sbjct: 541 VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPP-PPLPGM---MGIPPPPPP 596

Query: 304 IHYQHLMPPPPRLPPHLAVPPPGAIPPALHLN 335
                L   PP  PP   VPP    PP + LN
Sbjct: 597 ---PLLFGGPPPPPPLGGVPP----PPGISLN 621



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 26/51 (50%), Positives = 32/51 (62%), Gaps = 9/51 (17%)

Query: 271 PPSALP-LMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHL 320
           PP  LP +MG+PP   PPPPPL   FG PPPPP +     +PPPP +  +L
Sbjct: 580 PPPPLPGMMGIPP---PPPPPL--LFGGPPPPPPLGG---VPPPPGISLNL 622


>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
          Length = 1101

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 34/80 (42%), Positives = 39/80 (48%), Gaps = 14/80 (17%)

Query: 271 PPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPP 330
           PP+A PL G+ PPP PP PPL     +PPPPP +     +PPPP  P     PPP     
Sbjct: 551 PPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPP----- 605

Query: 331 ALHLNPAFFPPPNATVGPPP 350
                    PPP   V PPP
Sbjct: 606 ---------PPPLGGVPPPP 616



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 35/85 (41%), Positives = 40/85 (47%), Gaps = 10/85 (11%)

Query: 279 GLPPPPIPPPPPLSSSFGVPPPPPGIHY---QHLMPPPPRLPPHLAVPPPGAIPPALHLN 335
           G+P PP  PP P     G PPPPP         L PPPP LP  + +PPP   PP L   
Sbjct: 547 GIPGPPAAPPLP---GVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPP-PPLLFGG 602

Query: 336 PAFFPPPNATVGPPPDTYMKASAPY 360
           P   PPP    G PP   +  + PY
Sbjct: 603 P---PPPPPLGGVPPPPGISLNLPY 624



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 37/92 (40%), Positives = 45/92 (48%), Gaps = 18/92 (19%)

Query: 251 LVPSSARVDKPPSVLPYFN----RPPSALPLMG---LPPPPIPPPPPLSSSFGVPPPPPG 303
           ++ SS+ +  PP+  P        PP A PL G   LPPPP PP P +    G+PPPPP 
Sbjct: 541 VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPP-PPLPGM---MGIPPPPPP 596

Query: 304 IHYQHLMPPPPRLPPHLAVPPPGAIPPALHLN 335
                L   PP  PP   VPP    PP + LN
Sbjct: 597 ---PLLFGGPPPPPPLGGVPP----PPGISLN 621



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 26/51 (50%), Positives = 32/51 (62%), Gaps = 9/51 (17%)

Query: 271 PPSALP-LMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHL 320
           PP  LP +MG+PP   PPPPPL   FG PPPPP +     +PPPP +  +L
Sbjct: 580 PPPPLPGMMGIPP---PPPPPL--LFGGPPPPPPLGG---VPPPPGISLNL 622


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 39/98 (39%), Positives = 45/98 (45%), Gaps = 13/98 (13%)

Query: 251 LVPSSARVDKPPSVLPYFNRPPSALPLMGLPP-PPIPPPPPLSSSFGVPPP-------PP 302
           + P +A V  P  + P    PP      G PP PP PPPPP    F +PPP       PP
Sbjct: 662 VTPGAAAVAAPSVLAPTLPLPPPP----GFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPP 717

Query: 303 GIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFP 340
             H    +PPPP LP    VPPP  +PP     P  FP
Sbjct: 718 PAHPAVTVPPPP-LPAPPGVPPPPILPPLPPFPPGLFP 754



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 47/134 (35%), Positives = 55/134 (41%), Gaps = 15/134 (11%)

Query: 226 GGIPPRAHSRDSSDSADGRATP-SENLVPS----SARVDKPPSVLPYFNRPPSALPLMGL 280
           G   P +   D    + G     S++ +PS    SA   KP  V P       A P +  
Sbjct: 619 GDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTP--GAAAVAAPSVLA 676

Query: 281 PPPPIPPP---PPLSSSFGVPPPPPGIHYQHLMPPPPRLPP--HLAVPPPGAIPPALHLN 335
           P  P+PPP   PPL      PPP PG      +PPPP  PP  H AV  P   PP L   
Sbjct: 677 PTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVP---PPPLPAP 733

Query: 336 PAFFPPPNATVGPP 349
           P   PPP     PP
Sbjct: 734 PGVPPPPILPPLPP 747



 Score = 36.2 bits (82), Expect = 0.073
 Identities = 29/79 (36%), Positives = 35/79 (44%), Gaps = 10/79 (12%)

Query: 260  KPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPH 319
            +PP +LP   +PP  LP    P PP PPP P ++    P  PP    +   P  P L   
Sbjct: 1269 EPPMMLPLPLQPP--LPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGS 1326

Query: 320  LA-------VP-PPGAIPP 330
            LA       VP  PG  PP
Sbjct: 1327 LAKSQSTETVPATPGGEPP 1345



 Score = 33.9 bits (76), Expect = 0.36
 Identities = 29/102 (28%), Positives = 40/102 (39%), Gaps = 23/102 (22%)

Query: 227 GIPPRAHSRDSSDSAD----GRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGL-- 280
           G P +A  +DS+  A      +ATP+     + +    P +  P     P+A    G   
Sbjct: 365 GPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARD 424

Query: 281 --------PPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPP 314
                    PPP+PP  PL+     P  PPG       PPPP
Sbjct: 425 SGEFRRAPAPPPLPPAEPLAKE--KPGTPPG-------PPPP 457



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 23/71 (32%), Positives = 26/71 (36%), Gaps = 3/71 (4%)

Query: 283  PPIPPPPPLSSSFGVPPPPPGIHYQHLMPP-PPRLPPHLAVPPPGAIPPALHLNPAFFPP 341
            PP+ P         V P PP +    L PP PP  PP    PPP   P     +    PP
Sbjct: 1252 PPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPE--PETTDASHPSVPP 1309

Query: 342  PNATVGPPPDT 352
                   PP T
Sbjct: 1310 EPLAEDHPPHT 1320



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 30/98 (30%), Positives = 34/98 (34%), Gaps = 29/98 (29%)

Query: 279 GLPPPPIPPPPPLSSSFGVPPPP------PGIH-----YQHLM---PPPPRLPPHLA--- 321
           G   PP    P  S++F   PPP      PG       YQ  +   PPPP  P   A   
Sbjct: 362 GSSGPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFG 421

Query: 322 ---------VPPPGAIPPALHLNPAFFPPPNATVGPPP 350
                     P P  +PPA    P     P    GPPP
Sbjct: 422 ARDSGEFRRAPAPPPLPPA---EPLAKEKPGTPPGPPP 456



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 33/119 (27%), Positives = 37/119 (31%), Gaps = 25/119 (21%)

Query: 247  PSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLS-------------- 292
            P +   P       P +V   F       P   LPP P PPPPP                
Sbjct: 1510 PGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELDNQ 1569

Query: 293  -SSFGVPPPPPG-----IHYQHLMPP--PPRLPP---HLAVPPPGAIPPALHLNPAFFP 340
              S  +PP P G       Y  L     P R PP   H  + PP   P      P F P
Sbjct: 1570 WPSEAIPPGPRGRDEVTEEYMELAKSRGPWRRPPKKRHEDLVPPAGSPELSPPQPLFRP 1628



 Score = 29.3 bits (64), Expect = 9.0
 Identities = 39/119 (32%), Positives = 45/119 (37%), Gaps = 26/119 (21%)

Query: 239  DSADGRATPSE-NLVPSSARVDKP-PSVLPYFNRPPSA---LPLMGL---PPPPIPPPPP 290
            + AD R  P E  L    A +  P P       RPP +    P   L   P PP+  P P
Sbjct: 1218 EPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLP 1277

Query: 291  LSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPP 349
            L      PP PP        P PPR P   + PP      A H  P+  P P A   PP
Sbjct: 1278 LQ-----PPLPP--------PRPPRPP---SPPPEPETTDASH--PSVPPEPLAEDHPP 1318


>gi|157168329 formin 1 [Homo sapiens]
          Length = 1196

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 45/133 (33%), Positives = 53/133 (39%), Gaps = 23/133 (17%)

Query: 229 PPRAHS--RDSSDSADGRATPSENLVPSSARVDKPPSVLPY----FNRPPSALPLMGLPP 282
           PP  H     +    +G A+  +  +P       PP  LP      +  P   P+   PP
Sbjct: 620 PPNDHKDIHAALQPMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPP 679

Query: 283 --PPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFP 340
             PP PPPPPL       PPPP        PPPP LP   A P PG  PPA        P
Sbjct: 680 LPPPPPPPPPLPPPSSAGPPPP--------PPPPPLPNSPAPPNPGGPPPAP-------P 724

Query: 341 PPNATVGPPPDTY 353
           PP     PPP  +
Sbjct: 725 PPGLAPPPPPGLF 737



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 49/146 (33%), Positives = 63/146 (43%), Gaps = 28/146 (19%)

Query: 241 ADGRATPSENLVPSSARVDKPPSVLP---YFNRPPSALPLMG--------LPPPP--IPP 287
           ++ + T S  LVP    +     + P   + +   +  P+ G        LPPPP  IPP
Sbjct: 595 SESKTTRSNQLVPKKLNISSLSQLSPPNDHKDIHAALQPMEGMASNQQKALPPPPASIPP 654

Query: 288 PPPLSSSFG-VPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATV 346
           PPPL S  G + P PP       MPP    PP   +PPP   PP L    +  PPP    
Sbjct: 655 PPPLPSGLGSLSPAPP-------MPPVSAGPP---LPPPPPPPPPLPPPSSAGPPP---- 700

Query: 347 GPPPDTYMKASAPYNHHGSRDSGPPP 372
            PPP     + AP N  G   + PPP
Sbjct: 701 PPPPPPLPNSPAPPNPGGPPPAPPPP 726



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 36/131 (27%), Positives = 49/131 (37%), Gaps = 29/131 (22%)

Query: 215 ARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSA 274
           + +++ +  P   IPP         S  G  +P+  + P SA    PP   P    PP  
Sbjct: 639 SNQQKALPPPPASIPPPP----PLPSGLGSLSPAPPMPPVSAGPPLPPPPPP----PPPL 690

Query: 275 LPLMGLPPPPIPPPPPLSSSFG----------------VPPPPPGIHY-----QHLMPPP 313
            P     PPP PPPPPL +S                   PPPPPG+ +         P  
Sbjct: 691 PPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCPRK 750

Query: 314 PRLPPHLAVPP 324
           P + P   + P
Sbjct: 751 PAIEPSCPMKP 761


>gi|201023339 FIP1 like 1 isoform 2 [Homo sapiens]
          Length = 588

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 70/254 (27%), Positives = 91/254 (35%), Gaps = 39/254 (15%)

Query: 260 KPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPH 319
           KPP   P+F  PP A P   LPPPP  PPPP  S+     PPPGI    +  PPP  PP 
Sbjct: 340 KPP---PFF--PPGAPPTH-LPPPPFLPPPPTVSTAPPLIPPPGI---PITVPPPGFPPP 390

Query: 320 LAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAE 379
              PPP  IP     + + +   +A   P    Y   + P+   GS  S   PS V  ++
Sbjct: 391 PGAPPPSLIPTIESGHSSGYDSRSARAFP----YGNVAFPH-LPGSAPSW--PSLVDTSK 443

Query: 380 FEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSL 439
             D   R          +        D                + R    ER R    S 
Sbjct: 444 QWDYYARREKDRDRERDRDRERDRDRD----------------RERERTRERERERDHSP 487

Query: 440 KDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERN 499
              +   + + Y          +RHR+       SRE   RHR+  H E     +   R+
Sbjct: 488 TPSVFNSDEERYRYREYAERGYERHRA-------SREKEERHRERRHREKEETRHKSSRS 540

Query: 500 REHERHRDRERDRH 513
               RH   E D H
Sbjct: 541 NSRRRHESEEGDSH 554



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 58/234 (24%), Positives = 85/234 (36%), Gaps = 55/234 (23%)

Query: 291 LSSSFGVPPP--PPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGP 348
           + ++F  PPP  PPG    HL PPPP LPP          PP +   P   PPP   +  
Sbjct: 334 VDNNFSKPPPFFPPGAPPTHL-PPPPFLPP----------PPTVSTAPPLIPPPGIPITV 382

Query: 349 PPDTYMKASAPYNHHGSRDSGPPPS---TVSEAEFEDIMKRN-RAISSSAISKAVSGASA 404
           PP  +                PPPS   T+          R+ RA     ++      SA
Sbjct: 383 PPPGFPPP----------PGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSA 432

Query: 405 GDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRH 464
             +   ++T        ++ +  + ER R                           R R 
Sbjct: 433 PSWPSLVDTSKQWDYYARREKDRDRERDR------------------------DRERDRD 468

Query: 465 RSRERSPSRSRESSRRHR---DLLHNEDRHDDYFQERNREHERHR-DRERDRHH 514
           R RER  +R RE  R H     + ++++    Y +   R +ERHR  RE++  H
Sbjct: 469 RDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERH 522


>gi|91208418 transcription elongation regulator 1 isoform 2 [Homo
           sapiens]
          Length = 1077

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 43/121 (35%), Positives = 56/121 (46%), Gaps = 10/121 (8%)

Query: 243 GRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPP 302
           G    SE   P   R+ +  ++      PP    + G PPP + PPPP     G PPPPP
Sbjct: 6   GDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRG-PPPLMRPPPPFGMMRG-PPPPP 63

Query: 303 GIHYQHLMPPPPRLPPHLAVPPPGAIPPAL---HL-NPAFFPPPNATVGPPPDTYMKASA 358
              +    P  P +PP   +PPPG IPP +   HL  P F PPP +++ PPP        
Sbjct: 64  RPPFGR-PPFDPNMPP---MPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGM 119

Query: 359 P 359
           P
Sbjct: 120 P 120



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 33/84 (39%), Positives = 41/84 (48%), Gaps = 25/84 (29%)

Query: 261 PPSVLPYFNRPP--SALPLM----GLPPPPIPP--------PPPLSSSFGVPPPPPGIHY 306
           PP   P F RPP    +P M    G+PPP  PP        PPP+SS     PPPPG+ +
Sbjct: 60  PPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSM----PPPPGMMF 115

Query: 307 QHLMPPPPRLPPHLAVPPPGAIPP 330
                 PP +PP +  P   A+PP
Sbjct: 116 ------PPGMPP-VTAPGTPALPP 132



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 67/318 (21%), Positives = 107/318 (33%), Gaps = 62/318 (19%)

Query: 91  STEPPPPVRQEPSPKP------------------NNKTPAILYTYSGLRNRRAAVYVGSF 132
           S+ PPPP    P   P                   NKTP     Y   R R +A      
Sbjct: 105 SSMPPPPGMMFPPGMPPVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESA------ 158

Query: 133 SWWTTDQQLIQVIRSIGVYDVVELKF---AENRANGQSKGYAEVVVASENSVHKLLELLP 189
             WT     ++VI+   +  ++  +    A+ +A  Q++  A+    ++       +   
Sbjct: 159 --WTKPDG-VKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQA 215

Query: 190 GKVLNGEKVDVRPATRQNLSQFEAQARKRECVRV-----------PRGGIPPRAHSRDSS 238
                 +      A  Q  +Q +AQA+ +  V+            P    P  A S  +S
Sbjct: 216 QAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTS 275

Query: 239 DSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFG-V 297
            S     T +     S A+    P+     ++ PS+   +  P   +  P P ++    V
Sbjct: 276 SSTPSSTTSTTTTATSVAQTVSTPTTQ---DQTPSSAVSVATPTVSVSTPAPTATPVQTV 332

Query: 298 PPP-----PPGIHYQHLMPP------PPRLPPHLAVPPPGAIPPALHLNPAFFPP----- 341
           P P     PP + +    P       PP + P   VP PG   P   + P   PP     
Sbjct: 333 PQPHPQTLPPAVPHSVPQPTTAIPAFPPVMVPPFRVPLPGMPIPLPGVLPGMAPPIVPMI 392

Query: 342 -PNATVGPPPDTYMKASA 358
            P   +   P T   A+A
Sbjct: 393 HPQVAIAASPATLAGATA 410


>gi|21327715 transcription elongation regulator 1 isoform 1 [Homo
           sapiens]
          Length = 1098

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 43/121 (35%), Positives = 56/121 (46%), Gaps = 10/121 (8%)

Query: 243 GRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPP 302
           G    SE   P   R+ +  ++      PP    + G PPP + PPPP     G PPPPP
Sbjct: 6   GDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRG-PPPLMRPPPPFGMMRG-PPPPP 63

Query: 303 GIHYQHLMPPPPRLPPHLAVPPPGAIPPAL---HL-NPAFFPPPNATVGPPPDTYMKASA 358
              +    P  P +PP   +PPPG IPP +   HL  P F PPP +++ PPP        
Sbjct: 64  RPPFGR-PPFDPNMPP---MPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGM 119

Query: 359 P 359
           P
Sbjct: 120 P 120



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 33/84 (39%), Positives = 41/84 (48%), Gaps = 25/84 (29%)

Query: 261 PPSVLPYFNRPP--SALPLM----GLPPPPIPP--------PPPLSSSFGVPPPPPGIHY 306
           PP   P F RPP    +P M    G+PPP  PP        PPP+SS     PPPPG+ +
Sbjct: 60  PPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSM----PPPPGMMF 115

Query: 307 QHLMPPPPRLPPHLAVPPPGAIPP 330
                 PP +PP +  P   A+PP
Sbjct: 116 ------PPGMPP-VTAPGTPALPP 132



 Score = 30.4 bits (67), Expect = 4.0
 Identities = 31/116 (26%), Positives = 46/116 (39%), Gaps = 12/116 (10%)

Query: 245 ATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGI 304
           ATP +  VP       PP+V     +P +A+P      PP+  PP      G+P P PG+
Sbjct: 326 ATPVQT-VPQPHPQTLPPAVPHSVPQPTTAIPAF----PPVMVPPFRVPLPGMPIPLPGV 380

Query: 305 HYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFP--PPNATVGPPPDTYMKASA 358
               ++  P      +A    G +P    + P   P   P   +   P T   A+A
Sbjct: 381 AMMQIVSCP--YVKTVATTKTGVLP---GMAPPIVPMIHPQVAIAASPATLAGATA 431


>gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]
          Length = 424

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 69/249 (27%), Positives = 96/249 (38%), Gaps = 52/249 (20%)

Query: 125 AAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKL 184
           A +++G+      ++ L     + GV  +   K   +   G SKGYA +  AS ++    
Sbjct: 100 ANIFIGNLDPEIDEKLLYDTFSAFGVI-LQTPKIMRDPDTGNSKGYAFINFASFDASDAA 158

Query: 185 LELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGR 244
           +E      +NG+ +  RP T                           A  +DS     G 
Sbjct: 159 IE-----AMNGQYLCNRPITVSY------------------------AFKKDSKGERHGS 189

Query: 245 ATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGI 304
           A  +E L+ +        + L   +RP     L    PPP   P P+ SS G   PPPG 
Sbjct: 190 A--AERLLAAQ-------NPLSQADRPHQ---LFADAPPPPSAPNPVVSSLGSGLPPPG- 236

Query: 305 HYQHLMPPPPRLPPHLAVPPPGAIPPAL--HLNPAFFPPPNATVGPPPDTYMKASAPYNH 362
                MPPP   PP   VPPPGA+PP +   + P   PP  A  GPP      A  P + 
Sbjct: 237 -----MPPPGSFPP--PVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHG 289

Query: 363 HGSRDSGPP 371
           H      PP
Sbjct: 290 HSHPHPFPP 298



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 32/81 (39%), Positives = 36/81 (44%), Gaps = 6/81 (7%)

Query: 270 RPPSALPLMGLPPPPIPPP-PPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAI 328
           RPP  +P  G PP  +PP  PP  S  G P P P      +  PPP +PPH    PP   
Sbjct: 336 RPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPP---HGMRGPPPLMPPHGYTGPPRPP 392

Query: 329 PPALHLNPAFFPPPNATVGPP 349
           P      P   PPP  T  PP
Sbjct: 393 PYGYQRGP--LPPPRPTPRPP 411



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 32/83 (38%), Positives = 38/83 (45%), Gaps = 14/83 (16%)

Query: 260 KPPSVLPYFNRPPSALPLMGLP-------PPPIPP-----PPPLSSSFGV--PPPPPGIH 305
           +PP  +P+   PP  +P  G P       P P+PP     PPPL    G   PP PP   
Sbjct: 336 RPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYG 395

Query: 306 YQHLMPPPPRLPPHLAVPPPGAI 328
           YQ    PPPR  P   VPP G +
Sbjct: 396 YQRGPLPPPRPTPRPPVPPRGPL 418


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 34/81 (41%), Positives = 40/81 (49%), Gaps = 4/81 (4%)

Query: 246 TPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIH 305
           TPS+  +        PP  LP    P  A   + LPPPP PPPPP   S G PPPPP   
Sbjct: 300 TPSQQGIVLGPLAPPPPPPLP----PGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPP 355

Query: 306 YQHLMPPPPRLPPHLAVPPPG 326
             + +PPPP  PP   +P  G
Sbjct: 356 LPNQVPPPPPPPPAPPLPASG 376



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 74/317 (23%), Positives = 122/317 (38%), Gaps = 33/317 (10%)

Query: 205 RQNLSQFEAQARKRECV-RVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPS 263
           R+ L + E + ++RE   ++ R  +      R SS +A        N V   +   +P  
Sbjct: 232 RERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPG- 290

Query: 264 VLPYFNRPPSALPLMGL------PPPPIP-PPPPLSSSFGVPPPPPGIHYQHLMPPPPRL 316
            L   ++P       G+      PPPP P PP P  +S  +PPPP         PPPP  
Sbjct: 291 -LQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPG--------PPPPPP 341

Query: 317 PPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKA----SAPYNHHGSRDSGPPP 372
            P    PPP   PP  +  P   PPP A   P    ++ +    + P     +  +G   
Sbjct: 342 LPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKL 401

Query: 373 STVSEAEFEDIMKRNRAIS-SSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDER 431
             VS  E         AI  +SA SK  +G   G        L+  ++ +   R    E+
Sbjct: 402 RKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEK 461

Query: 432 CRVLISSLKDCLHGIEAKSYSVGASGSSS---------RKRHRSRERSPSRSRESSRRHR 482
              + +  K+   G +++  +  AS +S+         R    +  +SP  SR  S R  
Sbjct: 462 GSTIETEQKED-KGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKN 520

Query: 483 DLLHNEDRHDDYFQERN 499
            ++ +   +D   + ++
Sbjct: 521 QIVFDNRSYDSLHRPKS 537


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 34/81 (41%), Positives = 40/81 (49%), Gaps = 4/81 (4%)

Query: 246 TPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIH 305
           TPS+  +        PP  LP    P  A   + LPPPP PPPPP   S G PPPPP   
Sbjct: 300 TPSQQGIVLGPLAPPPPPPLP----PGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPP 355

Query: 306 YQHLMPPPPRLPPHLAVPPPG 326
             + +PPPP  PP   +P  G
Sbjct: 356 LPNQVPPPPPPPPAPPLPASG 376



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 51/174 (29%), Positives = 71/174 (40%), Gaps = 25/174 (14%)

Query: 205 RQNLSQFEAQARKRECV-RVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPS 263
           R+ L + E + ++RE   ++ R  +      R SS +A        N V   +   +P  
Sbjct: 232 RERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPG- 290

Query: 264 VLPYFNRPPSALPLMGL------PPPPIP-PPPPLSSSFGVPPPPPGIHYQHLMPPPPRL 316
            L   ++P       G+      PPPP P PP P  +S  +PPPP         PPPP  
Sbjct: 291 -LQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPG--------PPPPPP 341

Query: 317 PPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGP 370
            P    PPP   PP  +  P   PPP     PPP   + AS  +    S D+ P
Sbjct: 342 LPSTGPPPPPPPPPLPNQVPP--PPP-----PPPAPPLPASGFFLASMSEDNRP 388


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 46/121 (38%), Positives = 56/121 (46%), Gaps = 30/121 (24%)

Query: 224 PRGGIPPRAHSRD---SSDSADGRATPSENLVPS-SARVDKPPSVLPYFNRPPSALPLMG 279
           P  G+P  + S D   +++ A G A P    +P   +  + PPS       PP A PL G
Sbjct: 517 PTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSA------PPQAPPLPG 570

Query: 280 LPPPP--------IPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPA 331
            P PP        +PPPPP       PPPPPG      +PPPP  PP    PPPG  P A
Sbjct: 571 SPEPPPAPPLPGDLPPPPP------PPPPPPGT--DGPVPPPPPPPP----PPPGGPPDA 618

Query: 332 L 332
           L
Sbjct: 619 L 619



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 48/140 (34%), Positives = 54/140 (38%), Gaps = 14/140 (10%)

Query: 235 RDSSDSADGRATPSENLVPSSARVDKP--PSVLPYFNRPPSALPLMGLPPPPIPPPPPLS 292
           R   D+      P     PS      P  P+  P  +  P+A P  G  PPP PP P L 
Sbjct: 493 RGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLP 552

Query: 293 SSFGVPP--PP--PGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGP 348
           S    PP  PP  P +      PP P LP  L  PPP   PP     P   PPP     P
Sbjct: 553 SPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPV--PPPPPPPPP 610

Query: 349 PPDTYMKASAPYNHHGSRDS 368
           PP        P +  G RDS
Sbjct: 611 PP------GGPPDALGRRDS 624


>gi|56118221 amyloid beta (A4) precursor protein-binding, family B,
           member 1 interacting protein [Homo sapiens]
          Length = 666

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 46/134 (34%), Positives = 55/134 (41%), Gaps = 13/134 (9%)

Query: 224 PRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPP 283
           P+  +PP    R SSD++   ATP +        +  PP        PP  L    LPPP
Sbjct: 512 PKSSLPPPPPVRRSSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDDPELPPP 571

Query: 284 P---IPPPPPLSSSFGVPPPPP---GIHYQHLMPPPPRLPPHLAVPPPGAI--PPALHLN 335
           P   + PPP       VPPPPP   GI    L PPPP  P     P P +   PPA+   
Sbjct: 572 PPDFMEPPPDF-----VPPPPPSYAGIAGSELPPPPPPPPAPAPAPVPDSARPPPAVAKR 626

Query: 336 PAFFPPPNATVGPP 349
           P   P      G P
Sbjct: 627 PPVPPKRQENPGHP 640



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 50/162 (30%), Positives = 64/162 (39%), Gaps = 36/162 (22%)

Query: 224 PRGGIPPRAHSRDSS-DSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPP 282
           P G IP   HS  +    A   A  S++  P+       P+V    + P S+LP    PP
Sbjct: 465 PNGQIPQATHSVSAVLQEAQRHAETSKDKKPALGN-HHDPAVPRAPHAPKSSLP----PP 519

Query: 283 PPI--------PPPPPLSSSF----GVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPP 330
           PP+         P  PL +      G+P PP        +PPPP  PP   +  P   PP
Sbjct: 520 PPVRRSSDTSGSPATPLKAKGTGGGGLPAPP-----DDFLPPPPPPPP---LDDPELPPP 571

Query: 331 ALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPP 372
                P F  PP   V PPP +Y   +      GS    PPP
Sbjct: 572 P----PDFMEPPPDFVPPPPPSYAGIA------GSELPPPPP 603



 Score = 30.4 bits (67), Expect = 4.0
 Identities = 14/22 (63%), Positives = 16/22 (72%), Gaps = 1/22 (4%)

Query: 271 PPSALPLMGLPPPPIPPPPPLS 292
           PP A P++ LP PP PPP PLS
Sbjct: 130 PPPADPVLDLPLPP-PPPEPLS 150


>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
          Length = 502

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 56/168 (33%), Positives = 71/168 (42%), Gaps = 17/168 (10%)

Query: 240 SADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPP----PIPPPPPLSSSF 295
           S  G   P   +V  +     P   +P    PP   P  G PPP    P PPPPP +   
Sbjct: 320 SRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTP-RGPPPPGRGGPPPPPPPATGRS 378

Query: 296 G-VPPPPPGIHYQHLMPPPPRLPPHLAV---PPPGAIPPALHLNPAFFPPPNATVGPPPD 351
           G +PPPPPG     + PPPP  PP  +    P P  +PPA  L PA    P    G   D
Sbjct: 379 GPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPA--LVPAGGLAPGGGRGALLD 436

Query: 352 TYMKASAPYNHHGSRDSG---PPPST---VSEAEFEDIMKRNRAISSS 393
              +        G+ +S    PPP +   +  A    + KR+RAI SS
Sbjct: 437 QIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRAIHSS 484



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/96 (35%), Positives = 39/96 (40%), Gaps = 6/96 (6%)

Query: 284 PIPPPPPLSSSFGVPPPPP--GIHYQHLMPPPPRLPPHLAVPPP---GAIPPALHLNPAF 338
           P+PPPPP S      P PP  G +     P PP +P  +A PPP   G  PP     P  
Sbjct: 312 PLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPP-VPLGIAPPPPTPRGPPPPGRGGPPPP 370

Query: 339 FPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPST 374
            PP     GP P     A  P          PPPS+
Sbjct: 371 PPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSS 406


>gi|19923345 RNA binding motif protein 12 [Homo sapiens]
          Length = 932

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 61/238 (25%), Positives = 96/238 (40%), Gaps = 48/238 (20%)

Query: 165 GQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVP 224
           G   G A +V A++    +L  +  G  + G KV +  +++  +      +R+R      
Sbjct: 37  GGELGEAFIVFATDEDA-RLGMMRTGGTIKGSKVTLLLSSKTEMQNMIELSRRR--FETA 93

Query: 225 RGGIPPRAHSRDSSDSADGRAT-------------PSENLVPSSARVDK----------- 260
              IPP   SR     + G ++             PS ++V ++  V +           
Sbjct: 94  NLDIPPANASRSGPPPSSGMSSRVNLPTTVSNFNNPSPSVVTATTSVHESNKNIQTFSTA 153

Query: 261 -----PPSVLPYFNRPP-------SALPLMGLPPPPIPPPPPLSSSFGVP-----PPPPG 303
                PP++   F  P        +A P+  +PPPPIPP P + S   +P     P PP 
Sbjct: 154 SVGTAPPNMGASFGSPTFSSTVPSTASPMNTVPPPPIPPIPAMPSLPPMPSIPPIPVPPP 213

Query: 304 IHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYN 361
           +     +PP P +PP  +VPP   +PP   + P   PPP   V P P     + AP N
Sbjct: 214 VPTLPPVPPVPPIPPVPSVPPMTPLPPMSGM-PPLNPPP---VAPLPAGMNGSGAPMN 267



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 70/292 (23%), Positives = 109/292 (37%), Gaps = 46/292 (15%)

Query: 113 ILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAE 172
           IL     + + +   ++ +  +  T   ++Q +  I V +       +N  NGQ  G A 
Sbjct: 532 ILNPEGDVNSAKVCAHITNIPFSITKMDVLQFLEGIPVDENAVHVLVDN--NGQGLGQAL 589

Query: 173 VVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQ--ARKRECVRVPRGGIPP 230
           V   +E+   K  E L  K LNG +  V   T +++ + E    A+ ++ +++P  G P 
Sbjct: 590 VQFKNEDDARKS-ERLHRKKLNGREAFVHVVTLEDMREIEKNPPAQGKKGLKMPVPGNP- 647

Query: 231 RAHSRDSSDSADGRATPSENL----VPSSARVDKPPSVLPYFNRPPSALPLMGLPP---- 282
            A     +    G   PS  L    +PS+     P S +     P + +P  G+P     
Sbjct: 648 -AVPGMPNAGLPGVGLPSAGLPGAGLPSTGL---PGSAITSAGLPGAGMPSAGIPSAGGE 703

Query: 283 ---------------PPIPPPPPL--SSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPP 325
                          PP   P     S++FG P PPPG+         P +P   +V   
Sbjct: 704 EHAFLTVGSKEANNGPPFNFPGNFGGSNAFGPPIPPPGLGGGAFGDARPGMP---SVGNS 760

Query: 326 GAIPPALHLN-PAFFPPPNATVGPP-----PDTYMKASAPYNHHGSRDSGPP 371
           G   P L L+ P F   PN   GP      P  +              SGPP
Sbjct: 761 GL--PGLGLDVPGFGGGPNNLSGPSGFGGGPQNFGNGPGSLGGPPGFGSGPP 810


>gi|23510462 RNA binding motif protein 12 [Homo sapiens]
          Length = 932

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 61/238 (25%), Positives = 96/238 (40%), Gaps = 48/238 (20%)

Query: 165 GQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVP 224
           G   G A +V A++    +L  +  G  + G KV +  +++  +      +R+R      
Sbjct: 37  GGELGEAFIVFATDEDA-RLGMMRTGGTIKGSKVTLLLSSKTEMQNMIELSRRR--FETA 93

Query: 225 RGGIPPRAHSRDSSDSADGRAT-------------PSENLVPSSARVDK----------- 260
              IPP   SR     + G ++             PS ++V ++  V +           
Sbjct: 94  NLDIPPANASRSGPPPSSGMSSRVNLPTTVSNFNNPSPSVVTATTSVHESNKNIQTFSTA 153

Query: 261 -----PPSVLPYFNRPP-------SALPLMGLPPPPIPPPPPLSSSFGVP-----PPPPG 303
                PP++   F  P        +A P+  +PPPPIPP P + S   +P     P PP 
Sbjct: 154 SVGTAPPNMGASFGSPTFSSTVPSTASPMNTVPPPPIPPIPAMPSLPPMPSIPPIPVPPP 213

Query: 304 IHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYN 361
           +     +PP P +PP  +VPP   +PP   + P   PPP   V P P     + AP N
Sbjct: 214 VPTLPPVPPVPPIPPVPSVPPMTPLPPMSGM-PPLNPPP---VAPLPAGMNGSGAPMN 267



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 70/292 (23%), Positives = 109/292 (37%), Gaps = 46/292 (15%)

Query: 113 ILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAE 172
           IL     + + +   ++ +  +  T   ++Q +  I V +       +N  NGQ  G A 
Sbjct: 532 ILNPEGDVNSAKVCAHITNIPFSITKMDVLQFLEGIPVDENAVHVLVDN--NGQGLGQAL 589

Query: 173 VVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQ--ARKRECVRVPRGGIPP 230
           V   +E+   K  E L  K LNG +  V   T +++ + E    A+ ++ +++P  G P 
Sbjct: 590 VQFKNEDDARKS-ERLHRKKLNGREAFVHVVTLEDMREIEKNPPAQGKKGLKMPVPGNP- 647

Query: 231 RAHSRDSSDSADGRATPSENL----VPSSARVDKPPSVLPYFNRPPSALPLMGLPP---- 282
            A     +    G   PS  L    +PS+     P S +     P + +P  G+P     
Sbjct: 648 -AVPGMPNAGLPGVGLPSAGLPGAGLPSTGL---PGSAITSAGLPGAGMPSAGIPSAGGE 703

Query: 283 ---------------PPIPPPPPL--SSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPP 325
                          PP   P     S++FG P PPPG+         P +P   +V   
Sbjct: 704 EHAFLTVGSKEANNGPPFNFPGNFGGSNAFGPPIPPPGLGGGAFGDARPGMP---SVGNS 760

Query: 326 GAIPPALHLN-PAFFPPPNATVGPP-----PDTYMKASAPYNHHGSRDSGPP 371
           G   P L L+ P F   PN   GP      P  +              SGPP
Sbjct: 761 GL--PGLGLDVPGFGGGPNNLSGPSGFGGGPQNFGNGPGSLGGPPGFGSGPP 810


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 50/163 (30%), Positives = 64/163 (39%), Gaps = 20/163 (12%)

Query: 234  SRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLM---GLP-PPPIP--- 286
            S D  DS        E++  + + +D PP   P     P   PL     +P PPP+P   
Sbjct: 1381 SSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLP 1440

Query: 287  -------PPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFF 339
                   P PPL      P PPP    Q   PPPP  PP  A+P P   PP +   P+  
Sbjct: 1441 SANSNGTPEPPLLEEKPPPTPPPAPTPQP-QPPPPPPPPQPALPSP---PPLVAPTPSSP 1496

Query: 340  PPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFED 382
            PPP   + PPP   M +  P     +     PP   +    ED
Sbjct: 1497 PPP--PLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPED 1537



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 43/130 (33%), Positives = 52/130 (40%), Gaps = 16/130 (12%)

Query: 229  PPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVL-------PYFNRPPSALPLMGLP 281
            PP A  +D+S + DG        VP    +   PS         P     P   P     
Sbjct: 1408 PPLAGPKDTS-TPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPT 1466

Query: 282  PPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPP 341
            P P PPPPP      +P PPP +      PPPP LPP    PPP A+P      P   PP
Sbjct: 1467 PQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPP----PPPPAMPSP----PPPPPP 1518

Query: 342  PNATVGPPPD 351
              A +  PP+
Sbjct: 1519 AAAPLAAPPE 1528



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 32/103 (31%), Positives = 41/103 (39%), Gaps = 17/103 (16%)

Query: 287 PPPPLSSSFGVPPPPPGIHYQH--------LMPPPPRLPP----HLAVPPPGAIPPALH- 333
           PPPP  ++    P P G+  +         L PPPP+L P    H   P P A    +H 
Sbjct: 764 PPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHL 823

Query: 334 LNPAFF----PPPNATVGPPPDTYMKASAPYNHHGSRDSGPPP 372
           L PA       PP     PPP   ++  A    HG   + P P
Sbjct: 824 LEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSP 866



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 49/177 (27%), Positives = 66/177 (37%), Gaps = 42/177 (23%)

Query: 275 LPLMGLPPPPI----------PPPPPLSSSFGV------------------PPPPPGIHY 306
           LPL+ LPPPP           P P P +S  GV                  PPPPP +  
Sbjct: 790 LPLV-LPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPL 848

Query: 307 Q---HL-------MPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNAT-VGPPPDTYMK 355
           Q   HL         P PRL P  ++ PPGA+   L       P P  T VGPP      
Sbjct: 849 QLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKD 908

Query: 356 ASAPYNHHGSRDSGPPPST-VSEAEFEDIMKRNRAIS-SSAISKAVSGASAGDYSDA 410
            +  Y     + +  P    ++   F D + ++   S    + +   G +A DY  A
Sbjct: 909 PAGAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYGKA 965



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 26/73 (35%), Positives = 30/73 (41%), Gaps = 5/73 (6%)

Query: 253  PSSARVDKPPSVLPYFNRPPSALPLMGLPPPPI----PPPPPLSSSFGVPPPPPGIHYQH 308
            P  A    PP V P  + PP   PL   PPP +    PPPPP ++    PP  P      
Sbjct: 1478 PQPALPSPPPLVAPTPSSPPPP-PLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPE 1536

Query: 309  LMPPPPRLPPHLA 321
                P   P HLA
Sbjct: 1537 DPELPDTRPLHLA 1549



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 22/55 (40%), Positives = 24/55 (43%), Gaps = 9/55 (16%)

Query: 240  SADGRATPSENLVPSSARVDKPPSVLPYFNRPPSAL----PLMGLPPPPIPPPPP 290
            S  G  TP   L P+     KPP +    N  P  L    P    PPPP PPPPP
Sbjct: 999  SGAGPETPGLGLDPN-----KPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPP 1048



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 43/176 (24%), Positives = 54/176 (30%), Gaps = 54/176 (30%)

Query: 245 ATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPP---------------- 288
           A P  +  PSS+ +        + +RP      + L  PP  PP                
Sbjct: 135 ALPGSSTFPSSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPANGLLSPHDVLHLKPS 194

Query: 289 --PPLSSSFG-------------------VPPPPPGIHYQHLMPPPPRLPP---HLAVPP 324
             P + SS G                    PP  PG       PPPPR  P   +L    
Sbjct: 195 QAPTVPSSLGFERLAGGGVLGPAGLGPAQTPPYRPG---PPDPPPPPRHLPTQFNLLASS 251

Query: 325 PGAIPPALHLNPAFFPPPNATVGPPP--------DTYMKASAPYNHHGSRDSGPPP 372
             A   A   +P  +    A  GPPP        DT +K    Y    S    PPP
Sbjct: 252 SAAAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTVIK---HYQRPASAQPPPPP 304



 Score = 30.4 bits (67), Expect = 4.0
 Identities = 27/87 (31%), Positives = 29/87 (33%), Gaps = 31/87 (35%)

Query: 276  PLMGLPPPPIPP------PPPLSSSFGVPPPPPGIHYQHLMPPPPRLP------------ 317
            P  G  PPP PP      P     + G  P  PG+        PP LP            
Sbjct: 974  PKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDP--NKPPELPSTVNAEPLGLIQ 1031

Query: 318  --PHLAVPPPGAIPPALHLNPAFFPPP 342
              PH A PPP   PP         PPP
Sbjct: 1032 SGPHQAAPPPPPPPP---------PPP 1049



 Score = 30.0 bits (66), Expect = 5.3
 Identities = 28/105 (26%), Positives = 36/105 (34%), Gaps = 26/105 (24%)

Query: 281 PPPPIPPPPP--LSSSFGV------------PPPPPGIHYQHLMPPPPRLPPHLAVPPPG 326
           P PP PPPPP  L + F +               P   ++    P PP  PP  A+P   
Sbjct: 229 PGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPP--PPERALPRQD 286

Query: 327 AIPPALHLNPAFFPPPNATVGPPPDT-----YMKASAPYNHHGSR 366
            +        +  PPP     PPP       Y+     Y   G R
Sbjct: 287 TVIKHYQRPASAQPPP-----PPPPAHALQHYLSCGGSYPSMGHR 326



 Score = 29.6 bits (65), Expect = 6.9
 Identities = 17/39 (43%), Positives = 18/39 (46%), Gaps = 3/39 (7%)

Query: 289  PPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGA 327
            PPLS    VPP  P    + L P PP  P     PP GA
Sbjct: 1305 PPLSPPKSVPPSVPA---RGLQPQPPATPAVPHPPPSGA 1340



 Score = 29.6 bits (65), Expect = 6.9
 Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 9/71 (12%)

Query: 268  FNRPPSALPLMGLPPPPIPP-----PPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAV 322
            ++RPP  +   G    P+       PPP + +   PPP P    +     PP   P  A+
Sbjct: 1667 WHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPA---PPPKPETPEKTTSEKPPEQTPETAM 1723

Query: 323  P-PPGAIPPAL 332
            P PP    P+L
Sbjct: 1724 PEPPAPEKPSL 1734



 Score = 29.3 bits (64), Expect = 9.0
 Identities = 21/77 (27%), Positives = 29/77 (37%), Gaps = 5/77 (6%)

Query: 218  RECVRVP--RGGIPPRAHSRDSSD-SADGRATPSENLVPSSARVDKPPSVLPYFNRPPSA 274
            R C R P  R  +P R   +  +  SA G + P         + + P        +PP  
Sbjct: 1660 RVCARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTS--EKPPEQ 1717

Query: 275  LPLMGLPPPPIPPPPPL 291
             P   +P PP P  P L
Sbjct: 1718 TPETAMPEPPAPEKPSL 1734


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
           sapiens]
          Length = 1560

 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 42/118 (35%), Positives = 50/118 (42%), Gaps = 19/118 (16%)

Query: 260 KPPSVLPYFNRPPSALPLMGLPPPPIPPPPP----LSSSFGVPPPPPGIHYQHLMPPPPR 315
           +PPS     +RPPS  PL   PPP  PP  P    + +  GVPPP          PP P 
Sbjct: 802 RPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPP 861

Query: 316 LPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPS 373
           L P  + PP G +PPA HL              PP +   A A  +   SR   P PS
Sbjct: 862 LRPQ-SQPPEGPLPPAPHL--------------PPSSTSSAVASSSETSSRLPAPTPS 904



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 40/130 (30%), Positives = 52/130 (40%), Gaps = 22/130 (16%)

Query: 224 PRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPP 283
           P G +PP  H   SS S+   A+ SE    +S+R+  P         PPS  P     PP
Sbjct: 869 PEGPLPPAPHLPPSSTSS-AVASSSE----TSSRLPAPTPSDFQLQFPPSQGPHKSPTPP 923

Query: 284 P----IPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFF 339
           P    +P P         PPPPP   +Q +  P P      A+P P A+    H  P+  
Sbjct: 924 PTLHLVPEP-------AAPPPPPPRTFQMVTTPFP------ALPQPKALLERFHQVPSGI 970

Query: 340 PPPNATVGPP 349
              N   G P
Sbjct: 971 ILQNKAGGAP 980



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 21/51 (41%), Positives = 25/51 (49%), Gaps = 4/51 (7%)

Query: 271  PPSALPLMGLPPPPIPPPPPLSSSFG-VPPPPPGIHYQHLM---PPPPRLP 317
            PP+ L +   PP P PPPPP     G V  PPP    +  +   P  PRLP
Sbjct: 1336 PPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAPHCPRLP 1386



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 37/119 (31%), Positives = 40/119 (33%), Gaps = 29/119 (24%)

Query: 266  PYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPP 325
            P    PP    L    PPP PPP         PPPP G     +  PPP  P      P 
Sbjct: 1329 PVHQPPPPPATLKVAEPPPRPPP---------PPPPTGQMNGTVDHPPPAAPER---KPL 1376

Query: 326  GAIP--PALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSG----PPPSTVSEA 378
            G  P  P L L   +       VG P        AP      R  G    P P+ V EA
Sbjct: 1377 GTAPHCPRLPLRKTY----RENVGGP-------GAPEGTPAGRARGGSPAPLPAKVDEA 1424



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 27/116 (23%), Positives = 42/116 (36%), Gaps = 7/116 (6%)

Query: 263 SVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAV 322
           +VL     PPSA+ ++  P   + P  P +++    P          + P P+ PP ++ 
Sbjct: 581 TVLQGVTLPPSAVAMLNTPDGLVQPATPAAATGEAAPVLT-------VQPAPQAPPAVST 633

Query: 323 PPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEA 378
           P P  +       P   P P A   P   T   +    +       G PPS    A
Sbjct: 634 PLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTA 689



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 45/192 (23%), Positives = 67/192 (34%), Gaps = 39/192 (20%)

Query: 212 EAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVL------ 265
           + QA++      P+   PP+A +   S    G A+  E +V        P ++L      
Sbjct: 641 QPQAQQPPQAPTPQAAAPPQATTPQPSP---GLASSPEKIVLGQPPSATPTAILTQDSLQ 697

Query: 266 ----------------PYFNRPPSALPLMGLPPPPIPPPP--PLSSSFGVPPPPPGIHYQ 307
                           P+ + P S +  +  PPP   P P  P++   G+ P  P    Q
Sbjct: 698 MFLPQERSQQPLSAEGPHLSVPASVI--VSAPPPAQDPAPATPVAKGAGLGPQAP--DSQ 753

Query: 308 HLMPPPPRLP--PHLAVPPPGAIPPALHLNP----AFFPPPNATVGP--PPDTYMKASAP 359
               P P++P    L  P P + P   H  P       P P+ T  P  PP      S P
Sbjct: 754 ASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRP 813

Query: 360 YNHHGSRDSGPP 371
            +        PP
Sbjct: 814 PSEPPLHPCPPP 825



 Score = 29.6 bits (65), Expect = 6.9
 Identities = 30/120 (25%), Positives = 46/120 (38%), Gaps = 14/120 (11%)

Query: 224 PRGGIPPRAHSRDSSDSADGRATPSENLVPSSA-RVDKPPSVLPYF--NRPPSALPLMGL 280
           P G +PP+ +       A   AT +    P +  +  K P  L +    +    + L G 
Sbjct: 355 PAGVLPPKLYQLTPKPFAPAGATLTIQGEPGALPQQPKAPQNLTFMAAGKAGQNVVLSGF 414

Query: 281 PPPPIPP----PPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNP 336
           P P +       PP +++   PP PPG     L  P   +  HL       + PA H+ P
Sbjct: 415 PAPALQANVFKQPPATTTGAAPPQPPGA----LSKP---MSVHLLNQGSSIVIPAQHMLP 467


>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo
           sapiens]
          Length = 1792

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 64/246 (26%), Positives = 93/246 (37%), Gaps = 44/246 (17%)

Query: 272 PSALPLMGLPPPPIPPPPP--LSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIP 329
           P+    + +PPPP+ PPPP  L    GVPPP     +    PP    P   +VPPPG   
Sbjct: 551 PATPVFVPVPPPPLYPPPPHTLPLPPGVPPP----QFSPQFPPGQPPPAGYSVPPPG--- 603

Query: 330 PALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRA 389
                    FPP  A +  P   ++ +     H  +     P +       E+  +  R 
Sbjct: 604 ---------FPPAPANLSTP---WVSSGVQTAHSNT----IPTTQAPPLSREEFYREQRR 647

Query: 390 ISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAK 449
           +      K+       D++      L     I++ R  +  R +   S      +   + 
Sbjct: 648 LKEEEKKKSKLDEFTNDFAKE----LMEYKKIQKERRRSFSRSK---SPYSGSSYSRSSY 700

Query: 450 SYSVGASGSS-----SRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHER 504
           +YS   SGS+     SR   RS  RS SRS    RR R    N       ++ R+R H  
Sbjct: 701 TYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRN-------YRSRSRSHGY 753

Query: 505 HRDRER 510
           HR R R
Sbjct: 754 HRSRSR 759



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 27/93 (29%), Positives = 36/93 (38%), Gaps = 6/93 (6%)

Query: 281 PPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFP 340
           PPPPIPPP PL      P     I  Q     P  +P   +   P     +L  N +   
Sbjct: 339 PPPPIPPPRPLIQRNLQPLMRSPISRQQ---DPLMIPVTSSSTHPAPSISSLTSNQSSLA 395

Query: 341 PP---NATVGPPPDTYMKASAPYNHHGSRDSGP 370
           PP   N +  P P   + A+   + H  +  GP
Sbjct: 396 PPVSGNPSSAPAPVPDITATVSISVHSEKSDGP 428



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 37/168 (22%), Positives = 74/168 (44%), Gaps = 17/168 (10%)

Query: 359  PYNHHGSRDSGPPPSTVSEAEFE-DIMKRNRAISSSAISKAVSGASAGDYSDAI-----E 412
            P   H SR S        EA FE D  + +   + S   +  SG  + D  D I     E
Sbjct: 1616 PQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKE 1675

Query: 413  TLLTAIAVIKQSRVANDERCRVLIS-SLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSP 471
            +L TA AV++     N       +S S      G + +S+S  AS + S+   + +++  
Sbjct: 1676 SLDTA-AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKE 1734

Query: 472  SRSRESSRRHRDLLHNEDRHDDYFQERNREH-------ERHRDRERDR 512
             +  +  ++H+   H +    +   E++++H       ++++D+E+++
Sbjct: 1735 KKKHKKHKKHKK--HKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEK 1780



 Score = 30.4 bits (67), Expect = 4.0
 Identities = 16/62 (25%), Positives = 29/62 (46%), Gaps = 4/62 (6%)

Query: 457  GSSSRKRHRSRERSPSRSRESS----RRHRDLLHNEDRHDDYFQERNREHERHRDRERDR 512
            G S  + H S   SPSRS   S    R H     + +  D   +++ +E ++H+  ++ +
Sbjct: 1686 GISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHK 1745

Query: 513  HH 514
             H
Sbjct: 1746 KH 1747


>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
          Length = 1240

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 37/88 (42%), Positives = 40/88 (45%), Gaps = 14/88 (15%)

Query: 272 PSALPLMGLPPPPIPPPPPLSSSFGVPPPPP--------GIHYQHLMPPPPRLPPHLAVP 323
           P AL      PPP PPPP L  S   PPPPP        G       PPPP LP   A+ 
Sbjct: 411 PRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMA 470

Query: 324 PPG-AIPPALHLNPAFFPPPNATVGPPP 350
           PP   +PP L  +  F PPP     PPP
Sbjct: 471 PPAPPLPPPLPGSCEFLPPP-----PPP 493



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 39/93 (41%), Positives = 41/93 (44%), Gaps = 15/93 (16%)

Query: 271 PPSALPLMGLPPPPIPPPPPLSSSFG-----VPPPPPGIHYQHLMPPPPRLPPHLA---- 321
           PP  LP     PPP PPPPPL S         PPPPP      + PP P LPP L     
Sbjct: 426 PPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCE 485

Query: 322 -VPPPGAIPPALHLNPAFFPP---PNATVGPPP 350
            +PPP    P L   P   PP   P    GPPP
Sbjct: 486 FLPPPPPPLPGLGCPPP--PPPLLPGMGWGPPP 516



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 41/111 (36%), Positives = 48/111 (43%), Gaps = 17/111 (15%)

Query: 247 PSENLVPSSARVDKPPSVLPYFNR----------PPSALPLMGL---PPPPIPPPPPLSS 293
           P   L+P S+    PP   P              PP  LP +G    P PP+PPP P S 
Sbjct: 425 PPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSC 484

Query: 294 SFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNA 344
            F +PPPPP +      PPPP L P +   PP   PP L   P    PP A
Sbjct: 485 EF-LPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLL---PCTCSPPVA 531



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 39/109 (35%), Positives = 46/109 (42%), Gaps = 25/109 (22%)

Query: 261 PPSVLPYFNRPPSALPLMGLPPPPIP----------PPPPLSSSFG--------VPPPPP 302
           PP +LP  +  P   P    PPPP+P          PPPP     G        +PPP P
Sbjct: 426 PPPLLPGSSAEPPPPP----PPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLP 481

Query: 303 GIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPP--NATVGPP 349
           G   + L PPPP LP     PPP  + P +   P   PPP    T  PP
Sbjct: 482 G-SCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPP 529



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 38/107 (35%), Positives = 46/107 (42%), Gaps = 23/107 (21%)

Query: 261 PPSVLPYFNR-----PPSALPLMG----LPPPPIPPPPPLSSSFGVPPPP----PGIHYQ 307
           PP  LP         PP   PL G    LPPPP PP P L    G PPPP    PG+ + 
Sbjct: 459 PPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPP-PPLPGL----GCPPPPPPLLPGMGWG 513

Query: 308 HLMPPPPRLPPHLAVPPPGAIPPAL-----HLNPAFFPPPNATVGPP 349
              PPPP LP   + P  G +   +     H   + + P +  V PP
Sbjct: 514 PPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPP 560


>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
          Length = 1249

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 37/88 (42%), Positives = 40/88 (45%), Gaps = 14/88 (15%)

Query: 272 PSALPLMGLPPPPIPPPPPLSSSFGVPPPPP--------GIHYQHLMPPPPRLPPHLAVP 323
           P AL      PPP PPPP L  S   PPPPP        G       PPPP LP   A+ 
Sbjct: 411 PRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMA 470

Query: 324 PPG-AIPPALHLNPAFFPPPNATVGPPP 350
           PP   +PP L  +  F PPP     PPP
Sbjct: 471 PPAPPLPPPLPGSCEFLPPP-----PPP 493



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 39/93 (41%), Positives = 41/93 (44%), Gaps = 15/93 (16%)

Query: 271 PPSALPLMGLPPPPIPPPPPLSSSFG-----VPPPPPGIHYQHLMPPPPRLPPHLA---- 321
           PP  LP     PPP PPPPPL S         PPPPP      + PP P LPP L     
Sbjct: 426 PPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCE 485

Query: 322 -VPPPGAIPPALHLNPAFFPP---PNATVGPPP 350
            +PPP    P L   P   PP   P    GPPP
Sbjct: 486 FLPPPPPPLPGLGCPPP--PPPLLPGMGWGPPP 516



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 41/111 (36%), Positives = 48/111 (43%), Gaps = 17/111 (15%)

Query: 247 PSENLVPSSARVDKPPSVLPYFNR----------PPSALPLMGL---PPPPIPPPPPLSS 293
           P   L+P S+    PP   P              PP  LP +G    P PP+PPP P S 
Sbjct: 425 PPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSC 484

Query: 294 SFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNA 344
            F +PPPPP +      PPPP L P +   PP   PP L   P    PP A
Sbjct: 485 EF-LPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLL---PCTCSPPVA 531



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 39/109 (35%), Positives = 46/109 (42%), Gaps = 25/109 (22%)

Query: 261 PPSVLPYFNRPPSALPLMGLPPPPIP----------PPPPLSSSFG--------VPPPPP 302
           PP +LP  +  P   P    PPPP+P          PPPP     G        +PPP P
Sbjct: 426 PPPLLPGSSAEPPPPP----PPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLP 481

Query: 303 GIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPP--NATVGPP 349
           G   + L PPPP LP     PPP  + P +   P   PPP    T  PP
Sbjct: 482 G-SCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPP 529



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 38/107 (35%), Positives = 46/107 (42%), Gaps = 23/107 (21%)

Query: 261 PPSVLPYFNR-----PPSALPLMG----LPPPPIPPPPPLSSSFGVPPPP----PGIHYQ 307
           PP  LP         PP   PL G    LPPPP PP P L    G PPPP    PG+ + 
Sbjct: 459 PPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPP-PPLPGL----GCPPPPPPLLPGMGWG 513

Query: 308 HLMPPPPRLPPHLAVPPPGAIPPAL-----HLNPAFFPPPNATVGPP 349
              PPPP LP   + P  G +   +     H   + + P +  V PP
Sbjct: 514 PPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPP 560


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.133    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,943,802
Number of Sequences: 37866
Number of extensions: 2069209
Number of successful extensions: 34558
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 674
Number of HSP's successfully gapped in prelim test: 1231
Number of HSP's that attempted gapping in prelim test: 11813
Number of HSP's gapped (non-prelim): 10744
length of query: 514
length of database: 18,247,518
effective HSP length: 107
effective length of query: 407
effective length of database: 14,195,856
effective search space: 5777713392
effective search space used: 5777713392
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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