Search of human proteins with 216548395

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|216548395 dachsous 2 isoform 3 [Homo sapiens]
         (709 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|216548395 dachsous 2 isoform 3 [Homo sapiens]                     1417   0.0  
gi|216548385 dachsous 2 isoform 2 [Homo sapiens]                     1373   0.0  
gi|16933557 dachsous 1 precursor [Homo sapiens]                       398   e-110
gi|94538350 protocadherin 17 precursor [Homo sapiens]                 262   7e-70
gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso...   262   7e-70
gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs...   262   7e-70
gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precurs...   250   3e-66
gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precurs...   250   3e-66
gi|11056032 protocadherin gamma subfamily A, 1 isoform 1 precurs...   250   4e-66
gi|14196459 protocadherin gamma subfamily A, 1 isoform 2 precurs...   250   4e-66
gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precur...   246   4e-65
gi|14196448 protocadherin gamma subfamily A, 10 isoform 2 precur...   246   4e-65
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]       245   1e-64
gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]       245   1e-64
gi|157426847 protocadherin 19 isoform a [Homo sapiens]                241   1e-63
gi|157426845 protocadherin 19 isoform b [Homo sapiens]                241   1e-63
gi|14270484 protocadherin gamma subfamily A, 8 isoform 1 precurs...   241   2e-63
gi|7662056 protocadherin gamma subfamily A, 8 isoform 2 precurso...   241   2e-63
gi|14277677 protocadherin gamma subfamily C, 3 isoform 2 precurs...   240   3e-63
gi|14277675 protocadherin gamma subfamily C, 3 isoform 1 precurs...   240   3e-63
gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precurs...   240   3e-63
gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precurs...   240   3e-63
gi|14589880 protocadherin gamma subfamily A, 3 isoform 1 precurs...   239   5e-63
gi|14196465 protocadherin gamma subfamily A, 3 isoform 2 precurs...   239   5e-63
gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precur...   239   6e-63
gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precur...   239   6e-63
gi|14196455 protocadherin gamma subfamily A, 11 isoform 3 precur...   239   6e-63
gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precurs...   237   3e-62
gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precur...   237   3e-62
gi|14196468 protocadherin gamma subfamily A, 4 isoform 2 precurs...   237   3e-62

>gi|216548395 dachsous 2 isoform 3 [Homo sapiens]
          Length = 709

 Score = 1417 bits (3669), Expect = 0.0
 Identities = 709/709 (100%), Positives = 709/709 (100%)

Query: 1   MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS 60
           MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS
Sbjct: 1   MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS 60

Query: 61  GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120
           GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP
Sbjct: 61  GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120

Query: 121 DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS 180
           DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS
Sbjct: 121 DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS 180

Query: 181 PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS 240
           PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS
Sbjct: 181 PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS 240

Query: 241 SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE 300
           SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE
Sbjct: 241 SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE 300

Query: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
           YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE
Sbjct: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360

Query: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
           LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE
Sbjct: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420

Query: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480
           GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL
Sbjct: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480

Query: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540
           LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS
Sbjct: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540

Query: 541 QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600
           QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA
Sbjct: 541 QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600

Query: 601 ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660
           ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE
Sbjct: 601 ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660

Query: 661 PIFWRQVYNATIAEHAPVGHCFLQLISAQVAFVKIKQKQKEIQEKQNLA 709
           PIFWRQVYNATIAEHAPVGHCFLQLISAQVAFVKIKQKQKEIQEKQNLA
Sbjct: 661 PIFWRQVYNATIAEHAPVGHCFLQLISAQVAFVKIKQKQKEIQEKQNLA 709


>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
          Length = 1369

 Score = 1373 bits (3555), Expect = 0.0
 Identities = 684/688 (99%), Positives = 687/688 (99%)

Query: 1   MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS 60
           MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS
Sbjct: 1   MSPCGRKMGEGRQQRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRSLLWLLVHVWLWAAS 60

Query: 61  GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120
           GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP
Sbjct: 61  GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120

Query: 121 DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS 180
           DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS
Sbjct: 121 DTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS 180

Query: 181 PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS 240
           PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS
Sbjct: 181 PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS 240

Query: 241 SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE 300
           SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE
Sbjct: 241 SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE 300

Query: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
           YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE
Sbjct: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360

Query: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
           LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE
Sbjct: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420

Query: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480
           GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL
Sbjct: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480

Query: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540
           LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS
Sbjct: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540

Query: 541 QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600
           QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA
Sbjct: 541 QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600

Query: 601 ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660
           ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE
Sbjct: 601 ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660

Query: 661 PIFWRQVYNATIAEHAPVGHCFLQLISA 688
           PIFWRQVYNATIAEHAPVGHCFLQ+ ++
Sbjct: 661 PIFWRQVYNATIAEHAPVGHCFLQVTAS 688



 Score =  166 bits (419), Expect = 9e-41
 Identities = 180/579 (31%), Positives = 253/579 (43%), Gaps = 71/579 (12%)

Query: 129 RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           RRLDRE    +        G       ++ VE+RV D ND+ P F  D  +  V E + P
Sbjct: 252 RRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQP 311

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           G       A D D G      Y+ V+   +P   +G                L   +   
Sbjct: 312 GAEVCRVRATDRDLGPNGFVRYS-VRARQVPGAGSGG-------------GALGDAAYFA 357

Query: 243 LEPLDLVLL--RRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPP----VF 296
           +E L  V+   R LDRE  A H+L +EA DGG       + V + VLD NDN P    +F
Sbjct: 358 VEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417

Query: 297 EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL-----G 351
             +   A V E A+PG  V RV  +D D    G       A    G G G G++     G
Sbjct: 418 LTEGGVARVSEGARPGDYVARVSVSDAD----GDWEKEDEATGELGVGLGDGSISLSLEG 473

Query: 352 DAAYFAVEELSG------VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405
               FA+  L G       + V  PLDRE++  ++L++ A D G+ P      + + V D
Sbjct: 474 GEGDFAL--LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVAD 531

Query: 406 VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAD---GDWEKEDEATGELGVGL 462
           +ND  P    LF  +   A VSE A PG  V  VS SDAD    D         +L    
Sbjct: 532 LNDQPP----LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPC 587

Query: 463 GDGSI-SLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLST 521
             GS+ S  +   E   +       G   +     LDRE ++  EL +VA D G PPLS 
Sbjct: 588 NLGSLQSKMVHTAECGPSFAIDSESGA--ISTIRTLDREVQEAVELKVVAQDLGEPPLSA 645

Query: 522 EETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVV 581
              + + V D+ND  P+F +Q Y A+++E A  G   + V+ASDAD     + ++ Y++ 
Sbjct: 646 TCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD--SGLYGFIEYSLY 703

Query: 582 QLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAV-ELKVVAQDLGE 640
                   G L      + E   +F ID   G I   + +DRE   A  +L V A+D G 
Sbjct: 704 D-------GFL------SYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG- 749

Query: 641 PPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVG 679
             LSA   V + ++DVNDN P+F    Y  +I++    G
Sbjct: 750 -GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPG 787



 Score =  146 bits (368), Expect = 7e-35
 Identities = 157/561 (27%), Positives = 222/561 (39%), Gaps = 74/561 (13%)

Query: 131 LDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE RD Y  +          L     + +RV D+ND  P F     +  VSE + PGT
Sbjct: 497 LDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGT 556

Query: 185 AFRLPVAHDPD-AGL-FSTQGYTLVQ---PSDLPKDPAGPFFQLRYRTPGPLPSPLLPGS 239
                 A D D AG   +   YT+VQ   P +L     G        T    PS  +   
Sbjct: 557 VVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL-----GSLQSKMVHTAECGPSFAIDSE 611

Query: 240 SSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQD 299
           S  +  +     R LDRE   A  L++ A D G P  +    V + V D NDN P+F + 
Sbjct: 612 SGAISTI-----RTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666

Query: 300 EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVE 359
            Y A + E A  G    +V A+D D G  GF+ YS+          G  +      F ++
Sbjct: 667 VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY--------DGFLSYEAPQAFRID 718

Query: 360 ELSGVVRVWRPLDREAQ-AWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFL 418
              G + V + +DRE   A + L+VEA+DGG     A VRV +   DVNDN P    +F 
Sbjct: 719 PHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVNDNHP----VFN 772

Query: 419 TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDF 478
               V  +S+  +PG  +  V  +D D             G+    G+++  L  G    
Sbjct: 773 PSTYVTSISDETQPGTEIINVLATDQDS------------GI---YGTVAYELIPGNVSS 817

Query: 479 ALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPL 538
                   G+ +L +  PL         L++ A D G         + + +      P  
Sbjct: 818 LFTIDSTTGIIYLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875

Query: 539 FSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVH 598
           F +  Y   V E     + +  V A +                    P N        + 
Sbjct: 876 FERPKYTFLVYEDVPEDSPIGTVKARE--------------------PLNSSEPIFYRIS 915

Query: 599 TAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVND 658
           + + G  F+I    G I T + LD E Q  V L V AQ LG  P  ++  V+ITV DVND
Sbjct: 916 SGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEVNITVMDVND 974

Query: 659 NEPIFWRQVYNATIAEHAPVG 679
           N P F R      I++  P G
Sbjct: 975 NHPAFLRTSDEIRISQTTPPG 995



 Score =  110 bits (274), Expect = 6e-24
 Identities = 140/548 (25%), Positives = 219/548 (39%), Gaps = 93/548 (16%)

Query: 52   VHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSP 111
            +H++    + +  +    T  V E +P D+ +G ++A  P    +     F    S D  
Sbjct: 864  IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP---IFYRISSGD-- 918

Query: 112  LLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV-----VQVEIRVNDVNDHSPR 166
            L   F +HP  G IRT + LD E +          LG+       +V I V DVND+ P 
Sbjct: 919  LGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA 978

Query: 167  FPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
            F   S ++ +S+ +PPGTA  L  A D D+G      Y++  P                 
Sbjct: 979  FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ---------------- 1022

Query: 227  TPGPLPSPLLPGSSSPLEPLDLVLLR-RLDREEAAAHRLQIEAWDGGRPRRTGLLSVELR 285
                      PG  +    L ++ L   L   E     L + A D G   +  LL + + 
Sbjct: 1023 ----------PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV- 1071

Query: 286  VLDENDNPP--VFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGF---VRYSVRARQV 340
            V+++ ++ P   FE   Y+  V E   P  ++ + +A    LGP      +RYS+     
Sbjct: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSV- 1128

Query: 341  PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEA--RDGGAEPEVATVR 398
                       D+A F +   +G + + R  D E+   +   V A   + G    V+T  
Sbjct: 1129 -----------DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT- 1176

Query: 399  VSIAVLDVNDNRPAI--HVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATG 456
            V + V D NDN P     VLFL      +V E   P   + +++  D D    K  +   
Sbjct: 1177 VIVRVWDENDNSPTFLHDVLFL------KVEESPVPQGVIGKITAIDMDSG--KNGQLLY 1228

Query: 457  ELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGS 516
             L   L DG            F + P     + ++     LDRE R  +E+ ++ TD GS
Sbjct: 1229 FL---LSDGKF----------FKMNPNTGELINWVA----LDREHRGHHEMTVLVTDRGS 1271

Query: 517  PPLSTEETLLLRVADLNDQPPLFSQ----QHYKASVSEAAAPGTVVMWVSASDADEAGSD 572
            PP +    + + V D+ND  P F Q    +     V E      +V  V A D DE   +
Sbjct: 1272 PPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDE--GN 1329

Query: 573  HAWLRYTV 580
            +A + Y+V
Sbjct: 1330 NAEVTYSV 1337



 Score =  104 bits (259), Expect = 3e-22
 Identities = 155/593 (26%), Positives = 235/593 (39%), Gaps = 112/593 (18%)

Query: 116  FHVHPDTGIIRTARRLDRERRDH-YSFVAATL----LGAVVQVEIRVNDVNDHSPRFPLD 170
            F + P  G I  ++ +DRER    Y  +        L A   V + + DVND+ P F   
Sbjct: 715  FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPS 774

Query: 171  SLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGP 230
            +    +S+ + PGT     +A D D+G++ T  Y L+                       
Sbjct: 775  TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI----------------------- 811

Query: 231  LPSPLLPGSSSPLEPLD-----LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELR 285
                  PG+ S L  +D     + L   L   E+    L + A DGG         V + 
Sbjct: 812  ------PGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIH 865

Query: 286  VLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGS 345
            +      P  FE+ +Y   V ED    + +  V+A +  L  +  + Y +       +G 
Sbjct: 866  IFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRI------SSGD 918

Query: 346  GGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405
             GG       F++    G +R  +PLD E Q    L V+A+ G A P  ++  V+I V+D
Sbjct: 919  LGGK------FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEVNITVMD 971

Query: 406  VNDNRPAIHVLFLTEGGVARVSEGARPGD--YVARVSVSDADGDWEKEDEATGELGVGLG 463
            VNDN PA    FL      R+S+   PG   Y+AR            ED  +G       
Sbjct: 972  VNDNHPA----FLRTSDEIRISQTTPPGTALYLARA-----------EDRDSGR------ 1010

Query: 464  DGSISLSLEGGE-GDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
            +G I  S+   + G FA+      GV FL   G L    +    L L A D G  P +  
Sbjct: 1011 NGLIRYSIASPQPGVFAI--DRALGVLFL--NGSLGAGEQRELTLTLRAEDQGVHPQAAL 1066

Query: 523  ETLLLRVADLNDQPPLFSQQH--YKASVSEAAAPGTVVMWVSASDADEAGSDHAW--LRY 578
              L + V +  +  P ++ +H  Y+  VSE+ +P T ++    + A   G   A   LRY
Sbjct: 1067 LVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQML---QTQAHPLGPQRAASPLRY 1122

Query: 579  TVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVA--- 635
            ++          S+ S M         F I   +G I   R  D E  +    +V A   
Sbjct: 1123 SLEP--------SVDSAM---------FGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIP 1165

Query: 636  QDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISA 688
            +D     +S T +V +   D NDN P F   V    + E +PV    +  I+A
Sbjct: 1166 EDGFLQNVSTTVIVRVW--DENDNSPTFLHDVLFLKV-EESPVPQGVIGKITA 1215



 Score =  103 bits (256), Expect = 7e-22
 Identities = 123/480 (25%), Positives = 192/480 (40%), Gaps = 76/480 (15%)

Query: 199  FSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPL--------LPGSSSPLEPLDLVL 250
            F    YT +   D+P+D   P   ++ R P     P+        L G  S    L  + 
Sbjct: 876  FERPKYTFLVYEDVPED--SPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR 933

Query: 251  LRR-LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDA 309
             R+ LD E      L ++A  G  P  +    V + V+D NDN P F +      + +  
Sbjct: 934  TRKPLDHETQPVVVLTVQAQLGSAPACSST-EVNITVMDVNDNHPAFLRTSDEIRISQTT 992

Query: 310  QPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWR 369
             PG  +   RA DRD G NG +RYS+ + Q PG             FA++   GV+ +  
Sbjct: 993  PPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGV------------FAIDRALGVLFLNG 1039

Query: 370  PLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA---IHVLFLTEGGVARV 426
             L    Q    L + A D G  P+ A + +++ V++  ++ P+    H+++  E     V
Sbjct: 1040 SLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVE-----V 1093

Query: 427  SEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486
            SE   P   + +                   LG       +  SLE    D A+  G  P
Sbjct: 1094 SESLSPMTQMLQTQAH--------------PLGPQRAASPLRYSLEPSV-DSAMF-GIRP 1137

Query: 487  GVFFLCVEGPLDRESRDLYELLLVA---TDAGSPPLSTEETLLLRVADLNDQPPLFSQQH 543
               ++ +    D ES   Y   + A    D     +ST  T+++RV D ND  P F    
Sbjct: 1138 YTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST--TVIVRVWDENDNSPTFLHDV 1195

Query: 544  YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603
                V E+  P  V+  ++A D D +G +   L + +                      G
Sbjct: 1196 LFLKVEESPVPQGVIGKITAIDMD-SGKNGQLLYFLLSD--------------------G 1234

Query: 604  PSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIF 663
              F ++  +G +     LDRE +   E+ V+  D G PP +AT  V ++V D+NDN P F
Sbjct: 1235 KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF 1294


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score =  398 bits (1022), Expect = e-110
 Identities = 257/641 (40%), Positives = 351/641 (54%), Gaps = 67/641 (10%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
           LL LL+ +      G+  Q  +L L +DE  P  TL+GDI AGLPA        F  +++
Sbjct: 25  LLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQE 84

Query: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPR 166
              S +  D  +   +G++RTAR LDRE+RD Y F A T  GA V+V +RV D+NDH+P 
Sbjct: 85  G--SGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPA 142

Query: 167 FPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYR 226
           FP     L V E +  GT + L  A D DAG   TQGY L        D AG  F+L  R
Sbjct: 143 FPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYAL------SGDGAGETFRLETR 196

Query: 227 TPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRV 286
            PGP  +P+           +LV+   LDRE  + + LQ+EA+DGG P R     +++ +
Sbjct: 197 -PGPDGTPVP----------ELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTL 245

Query: 287 LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
           LD ND+ P F Q  Y A V E   PG+ V +V A+D D G NG V Y +  RQ  G G  
Sbjct: 246 LDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGP- 304

Query: 347 GGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDV 406
                    F+++  +G++++ RPLD E +  H+LVV+ARDGGA PE+ +  V++ V D 
Sbjct: 305 ---------FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDA 355

Query: 407 NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDA-DGDWEKEDEATGELGVGLGDG 465
           NDN+P++ V+FL+  G  +VSE A PG  VAR+SVSD  DGD+                 
Sbjct: 356 NDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDF----------------A 399

Query: 466 SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
            +++SLEGGEG FAL       ++ +CV   LDRE RD Y L + ATD+GSPPL  E   
Sbjct: 400 HVNVSLEGGEGHFALSTQDSV-IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAF 458

Query: 526 LLRVADLNDQPPLFSQQHYKAS-VSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLS 584
           +L V D+ND  P F +Q Y+   + E A PG+ V+ V+A D D+  +        V    
Sbjct: 459 VLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQ------VTYSL 512

Query: 585 APCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLS 644
           AP           HT      F+ID  SG I+T  +LD E++   +L VVA D G PPL+
Sbjct: 513 AP---------GAHT----HWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLA 559

Query: 645 ATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
           ++  VS+ + DVNDNEP F R  YNA++ E    G CFLQ+
Sbjct: 560 SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQV 600



 Score =  215 bits (548), Expect = 1e-55
 Identities = 199/629 (31%), Positives = 274/629 (43%), Gaps = 100/629 (15%)

Query: 69   LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTA 128
            LT++  EGL P +L+G + A  PA             D + +  LD       +G +  A
Sbjct: 1337 LTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALD-----AASGRLYLA 1391

Query: 129  RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
            R LD E    +  +     G       +++V+++V D N+H+P F  D L L + E   P
Sbjct: 1392 RPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEP 1451

Query: 183  GTAFRLPVAHDPDA-GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
            G A     A D D  G  S   Y L++     ++P  P  +L  RT G L +P       
Sbjct: 1452 GAALYTFRASDADGPGPNSDVRYRLLR-----QEPPVPALRLDART-GALSAP------- 1498

Query: 242  PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP-----RRTGLLSVELRVLDENDNPPVF 296
                      R LDRE   A  L +EA D  RP     RR   +S  + V DENDN PVF
Sbjct: 1499 ----------RGLDRETTPALLLLVEATD--RPANASRRRAARVSARVFVTDENDNAPVF 1546

Query: 297  EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
                 R  + ED  PG     V A D DLG    V Y +             A G   +F
Sbjct: 1547 ASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRL-------------ASGGDGHF 1592

Query: 357  AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVL 416
             +   +G + V RPLDRE +A H L V A D G+ P  AT  ++++V DVND  P     
Sbjct: 1593 RLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPT---- 1648

Query: 417  FLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEG 476
            F  +     + E   PG  +  +  +D D        A G++  G G  S S SL+   G
Sbjct: 1649 FQQQEYSVLLRENNPPGTSLLTLRATDPDVG------ANGQVTYG-GVSSESFSLDPDTG 1701

Query: 477  DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
                L               LDRE ++   L + A D GSPP  T  T+ + V D ND  
Sbjct: 1702 VLTTLRA-------------LDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHA 1748

Query: 537  PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
            P F   H    V E   P T+ M + ASD D   +                  G LQ ++
Sbjct: 1749 PTFGSAHLSLEVPEGQDPQTLTM-LRASDPDVGAN------------------GQLQYRI 1789

Query: 597  VHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDV 656
            +     G +F +D  SG   T+R LDREV+ A +L++ A+D G+P LSAT L+++TV D 
Sbjct: 1790 LDGDPSG-AFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDA 1848

Query: 657  NDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
            ND+ P F    Y+  + E  P G   LQL
Sbjct: 1849 NDHAPAFPVPAYSVEVPEDVPAGTLLLQL 1877



 Score =  183 bits (465), Expect = 4e-46
 Identities = 169/554 (30%), Positives = 231/554 (41%), Gaps = 97/554 (17%)

Query: 122  TGIIRTARRLDRERRDHYSFV---------AATLLGAVVQVEIRVNDVNDHSPRFPLDSL 172
            TG +   R LDRE       +         A+    A V   + V D ND++P F   S 
Sbjct: 1492 TGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS- 1550

Query: 173  QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
            ++ + E  PPG A    VA DPD G  +   Y L    D         F+L   T     
Sbjct: 1551 RVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGD-------GHFRLHSSTGA--- 1600

Query: 233  SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
                           L ++R LDRE+ A H L + A D G P R+    + + V D ND 
Sbjct: 1601 ---------------LSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDE 1645

Query: 293  PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
             P F+Q EY   +RE+  PG  +  +RATD D+G NG V Y             GG   +
Sbjct: 1646 APTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY-------------GGVSSE 1692

Query: 353  AAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA 412
            +  F+++  +GV+   R LDRE Q    L V A+D G+ P++  V V +AV D ND+ P 
Sbjct: 1693 S--FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPT 1750

Query: 413  IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGL--GDGSISLS 470
                 L+      V EG  P   +  +  SD D        A G+L   +  GD S +  
Sbjct: 1751 FGSAHLS----LEVPEGQDP-QTLTMLRASDPDVG------ANGQLQYRILDGDPSGAFV 1799

Query: 471  LEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVA 530
            L+   G+F  +              PLDRE    ++L + A D G P LS    L + V 
Sbjct: 1800 LDLASGEFGTMR-------------PLDREVEPAFQLRIEARDGGQPALSATLLLTVTVL 1846

Query: 531  DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
            D ND  P F    Y   V E    GT+++ + A D D   + H               LG
Sbjct: 1847 DANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGH-----------VTYYLG 1895

Query: 591  SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQD-LGEPPLSATCLV 649
                     A    +F ++  SG + T   LDRE   +    V A D     PLS T  V
Sbjct: 1896 ---------AGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSV 1946

Query: 650  SITVDDVNDNEPIF 663
            +ITV DVND+ P F
Sbjct: 1947 TITVRDVNDHAPTF 1960



 Score =  182 bits (463), Expect = 7e-46
 Identities = 171/567 (30%), Positives = 239/567 (42%), Gaps = 84/567 (14%)

Query: 131 LDRERRDHYSFVAATLLG------AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE R HY        G      A   +++ + D+NDH+P F        VSE   PG+
Sbjct: 213 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
                 A D DAG+     Y + +      +  GPF                   S    
Sbjct: 273 PVLQVFASDADAGVNGAVTYEINRRQS---EGDGPF-------------------SIDAH 310

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPP----VFEQDE 300
              L L R LD E+   H L ++A DGG     G   V + V D NDN P    +F   +
Sbjct: 311 TGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSAD 370

Query: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
               V E A PG  V R+  +D D G    V  S+            G  G  A    + 
Sbjct: 371 GSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLE-----------GGEGHFALSTQDS 419

Query: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLT 419
           +  +V V R LDRE +  + L V A D G+ P  A     + V DVNDN PA    L+  
Sbjct: 420 VIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRP 479

Query: 420 EGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFA 479
           E     + E A PG +V RV+  D D       + T        +G ++ SL  G     
Sbjct: 480 EP----LPEVALPGSFVVRVTARDPD-------QGT--------NGQVTYSLAPGAHTHW 520

Query: 480 LLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLF 539
                  G+  +     LD E     +L++VATD G PPL++  T+ + + D+ND  P F
Sbjct: 521 FSIDPTSGI--ITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQF 578

Query: 540 SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHT 599
            +  Y AS+ E   PGT  + V+A+DAD          + ++  S    LGS  S     
Sbjct: 579 QRTFYNASLPEGTQPGTCFLQVTATDADSG-------PFGLLSYSLGAGLGSSGS----- 626

Query: 600 AECGPSFAIDSESGAISTIRTLDREV-QEAVELKVVAQDLGEPPLSATCLVSITVDDVND 658
               P F ID+ SG + T RTLDR+    + +  V A D G   L +   V + + D ND
Sbjct: 627 ----PPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDEND 680

Query: 659 NEPIFWRQVYNATIAEHAPVGHCFLQL 685
           N P F+ + Y A+I+  +P G   L+L
Sbjct: 681 NPPQFYPREYAASISAQSPPGTAVLRL 707



 Score =  173 bits (438), Expect = 6e-43
 Identities = 198/688 (28%), Positives = 276/688 (40%), Gaps = 103/688 (14%)

Query: 24   LLPGRRDTPHGRSGSSGARTQRSLLWL------LVHVWLWAASGSSAQLFNLTLSVDEGL 77
            +L G          S+GA T RS   L       + + L A SG +     LTL++ +  
Sbjct: 2106 ILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDAN 2165

Query: 78   P--PDTLVGDIRAGLPAAQQQEGSGFFLSEDSDD----------------SPLLDDFHVH 119
               P  L     A LP ++  EG    L  ++DD                 P    FHV 
Sbjct: 2166 DNAPRFLRPHYVAFLPESRPLEGP--LLQVEADDLDQGSGGQISYSLAASQPARGLFHVD 2223

Query: 120  PDTGIIRTARRLDRERRDHYSFV-------AATLLGAVVQVEIRVNDVNDHSPRFPLDSL 172
            P TG I T   LDRE       V       +  L+G+   + + V D ND+ P  P    
Sbjct: 2224 PTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSAT-LTVMVIDTNDNRPTIP-QPW 2281

Query: 173  QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
            +L VSE +  G+       +D D+G      Y L      P  P  PF   RY     L 
Sbjct: 2282 ELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLS-----PSGPQDPFSVGRYGGRVSLT 2334

Query: 233  SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
             PL                   D E+   ++LQ+ A DG    R  L  +   V D NDN
Sbjct: 2335 GPL-------------------DFEQCDRYQLQLLAHDGPHEGRANLTVL---VEDVNDN 2372

Query: 293  PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
             P F Q  Y+  + E   PG+ +  V ATDRD G NG + Y +       A    G   D
Sbjct: 2373 APAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL-------ASPADGFSVD 2425

Query: 353  AAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA 412
                 +  + G V     L  +      +V+EARD GA    A   V + + D ND+ P+
Sbjct: 2426 PNNGTLFTIVGTVA----LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPS 2481

Query: 413  IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLE 472
                 L+   VA V+E   PG  +  +  +DADG       A  +  +  G+      LE
Sbjct: 2482 FT---LSHYRVA-VTEDLPPGSTLLTLEATDADGS---RSHAAVDYSIISGNWGRVFQLE 2534

Query: 473  GGEGDFALLPG-GPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVAD 531
                +     G GP  +  L +  PLD ES   Y L + A D G PP S+   + + V D
Sbjct: 2535 PRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLD 2594

Query: 532  LNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGS 591
            +ND PP+F++  Y+ +V E    G  ++ V ASDAD     H  +R+TV     P  L  
Sbjct: 2595 VNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPG--PHGLVRFTVSS-GDPSGL-- 2649

Query: 592  LQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSI 651
                          F +D  SG +     LD E Q   +L V A D       A   V+I
Sbjct: 2650 --------------FELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF-ALAPVTI 2694

Query: 652  TVDDVNDNEPIFWRQVYNATIAEHAPVG 679
             V DVND+ P F   + + ++AE+ P G
Sbjct: 2695 EVQDVNDHGPAFPLNLLSTSVAENQPPG 2722



 Score =  164 bits (416), Expect = 2e-40
 Identities = 192/658 (29%), Positives = 272/658 (41%), Gaps = 133/658 (20%)

Query: 74   DEGLPPDTL-------VGDIRAGLPAAQQQEGSGFFLSEDSDDSPLL------------- 113
            D G PP +        V D+    P  QQQE S      +   + LL             
Sbjct: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANG 1682

Query: 114  ---------DDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLGAVVQ-----VEIRVN 158
                     + F + PDTG++ T R LDRE ++  +  V A   G+  Q     V + V 
Sbjct: 1683 QVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVE 1742

Query: 159  DVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAG 218
            D NDH+P F    L L+V E   P T   L  A DPD G      Y +     L  DP+G
Sbjct: 1743 DENDHAPTFGSAHLSLEVPEGQDPQTLTMLR-ASDPDVGANGQLQYRI-----LDGDPSG 1796

Query: 219  PFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTG 278
             F              L  G    + PLD        RE   A +L+IEA DGG+P  + 
Sbjct: 1797 AFVL-----------DLASGEFGTMRPLD--------REVEPAFQLRIEARDGGQPALSA 1837

Query: 279  LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
             L + + VLD ND+ P F    Y   V ED   G  + +++A D D G NG V Y +   
Sbjct: 1838 TLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--- 1894

Query: 339  QVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE-PEVATV 397
               GAG+ G        F +E  SG +R    LDRE    +   V A DG A  P   TV
Sbjct: 1895 ---GAGTAGA-------FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTV 1944

Query: 398  RVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGE 457
             V+I V DVND+ P     F T     R+    RPG   +  +++ A      ED   G 
Sbjct: 1945 SVTITVRDVNDHAPT----FPTSPLRLRL---PRPGPSFSTPTLALA--TLRAEDRDAG- 1994

Query: 458  LGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEG-------PLDRESRDLYELLLV 510
                  + SI   L G           PPG       G       P+    RD   L +V
Sbjct: 1995 -----ANASILYRLAGTP---------PPGTTVDSYTGEIRVARSPVALGPRDRV-LFIV 2039

Query: 511  ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
            ATD G P  S    +++ +    ++ P F +   +A++ E A PGT ++   +  A  AG
Sbjct: 2040 ATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV---SPRAVHAG 2096

Query: 571  SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQE 627
              +  + Y+++        G+ +           +F+I   +GAI T+R+   LD EV  
Sbjct: 2097 GTNGPITYSILS-------GNEKG----------TFSIQPSTGAI-TVRSAEGLDFEVSP 2138

Query: 628  AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
             + L + A+  G     A  ++++T+ D NDN P F R  Y A + E  P+    LQ+
Sbjct: 2139 RLRLVLQAESGG---AFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQV 2193



 Score =  163 bits (412), Expect = 6e-40
 Identities = 167/562 (29%), Positives = 243/562 (43%), Gaps = 81/562 (14%)

Query: 114  DDFHVHPDTGIIRT-------------ARRLDRERRDHYSFVAATLLGAVVQVEIRVNDV 160
            D F V P+ G + T             A  +  E RDH     A    A   V +++ D 
Sbjct: 2420 DGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDH----GAPGRAARATVHVQLQDQ 2475

Query: 161  NDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGL-FSTQGYTLVQPSDLPKDPAGP 219
            NDH+P F L   ++ V+E  PPG+      A D D     +   Y+++  +       G 
Sbjct: 2476 NDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGN------WGR 2529

Query: 220  FFQLRYR------TPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGR 273
             FQL  R      + GP P  L  G         LVLL  LD E    + L + A D G+
Sbjct: 2530 VFQLEPRLAEAGESAGPGPRAL--GC--------LVLLEPLDFESLTQYNLTVAAADRGQ 2579

Query: 274  PRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRY 333
            P ++ ++ V + VLD NDNPPVF +  YR  V ED   GAE+  V A+D D GP+G VR+
Sbjct: 2580 PPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRF 2639

Query: 334  SVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE 393
            +V +    G             F ++E SG +R+   LD E QA HQLVV+A D  A   
Sbjct: 2640 TVSSGDPSG------------LFELDESSGTLRLAHALDCETQARHQLVVQAAD-PAGAH 2686

Query: 394  VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAD-GDWEKED 452
             A   V+I V DVND+ PA  +  L+      V+E   PG  V  +   D D G + +  
Sbjct: 2687 FALAPVTIEVQDVNDHGPAFPLNLLS----TSVAENQPPGTLVTTLHAIDGDAGAFGRLR 2742

Query: 453  EATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVAT 512
             +  E G G  +G  + +L    G+             L    P D E  + + LL+ A 
Sbjct: 2743 YSLLEAGPG-PEGREAFALNSSTGE-------------LRARVPFDYEHTESFRLLVGAA 2788

Query: 513  DAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSD 572
            DAG+  LS   T+ + V   ++  P+F    +   V E A  G  +  V A+D D  G  
Sbjct: 2789 DAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDED--GGA 2844

Query: 573  HAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELK 632
               + Y++   S    +      +    +     +  + SG     R   RE    + L+
Sbjct: 2845 DGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTR---REAPRELRLE 2901

Query: 633  VVAQDLGEPPLSATCLVSITVD 654
            V+A+  G  P S +  V +TVD
Sbjct: 2902 VIAR--GPLPGSRSATVPVTVD 2921



 Score =  160 bits (405), Expect = 4e-39
 Identities = 174/637 (27%), Positives = 250/637 (39%), Gaps = 143/637 (22%)

Query: 116  FHVHPDTGIIRTARRLDRERR-DHYSFVAATLLG----AVVQVEIRVNDVNDHSPRFPLD 170
            F +   +G + T R LDR++    + F    + G    ++V V++ ++D ND+ P+F   
Sbjct: 629  FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPR 688

Query: 171  SLQLDVSELSPPGTAFRLPVAHDP------------------------------------ 194
                 +S  SPPGTA     AHDP                                    
Sbjct: 689  EYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPL 748

Query: 195  ---------------DAGLFSTQGYTLVQPSDLPKDPAGPFF-QLRY------------- 225
                           D G    +    V  S +P  P  P F QL+Y             
Sbjct: 749  ARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTS 808

Query: 226  -------RTPG---PLPSPLLPGSSSPLEPLDLV-----LLRRLDREEAAAHRLQIEAWD 270
                     PG   P+   L  G    L  LD V      LR LDRE      L++E   
Sbjct: 809  VGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRE-LLGPVLELEVRA 867

Query: 271  G-GRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNG 329
            G G P    +  V + + D NDN P F   E    +  +  PG  +  +RA D D G N 
Sbjct: 868  GSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNS 927

Query: 330  FVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGG 389
             V +++ A        GGGA      F V+  +G VR+ RPL       H+L +EARDGG
Sbjct: 928  RVTFTLLA-------GGGGA------FTVDPTTGHVRLMRPLGPSGGPAHELELEARDGG 974

Query: 390  AEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWE 449
            + P  +  R+ + V DV     A    F +      +  G   G  V +V     DG   
Sbjct: 975  SPPRTSHFRLRVVVQDVGTRGLAPR--FNSPTYRVDLPSGTTAGTQVLQVQAQAPDG--- 1029

Query: 450  KEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLL 509
                         G  +  L+ EG    F L P       +L V   LDRE+++LY L +
Sbjct: 1030 -------------GPITYHLAAEGASSPFGLEPQSG----WLWVRAALDREAQELYILKV 1072

Query: 510  VATDAGSPPLSTEE---TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDA 566
            +A       L  +    T+ + + + N+  P  S+     +V+E   PGT V  V A+D 
Sbjct: 1073 MAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDR 1132

Query: 567  DEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQ 626
            D   +    L Y++ QLS                E   +F I  ++G ++T++TLDRE Q
Sbjct: 1133 DSGPNGR--LTYSLQQLS----------------EDSKAFRIHPQTGEVTTLQTLDREQQ 1174

Query: 627  EAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIF 663
             + +L V  QD G PP S T  V + V D+NDN P F
Sbjct: 1175 SSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTF 1211



 Score =  152 bits (384), Expect = 1e-36
 Identities = 161/587 (27%), Positives = 230/587 (39%), Gaps = 122/587 (20%)

Query: 122  TGIIRTARR-LDRERRDHYSFVAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLD 175
            TG IR AR  +    RD   F+ AT LG     A   + + +    +  PRFP  S +  
Sbjct: 2017 TGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEAT 2076

Query: 176  VSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPL 235
            + E +PPGT    P A                                   T GP+   +
Sbjct: 2077 IRENAPPGTPIVSPRAVHAGG------------------------------TNGPITYSI 2106

Query: 236  LPGSSS---PLEPLDLVLLRR----LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
            L G+      ++P    +  R    LD E +   RL ++A  GG    T L    L + D
Sbjct: 2107 LSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLT---LTLQD 2163

Query: 289  ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
             NDN P F +  Y A + E       + +V A D D G  G + YS+ A Q P  G    
Sbjct: 2164 ANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQ-PARG---- 2218

Query: 349  ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVND 408
                   F V+  +G +     LDRE  A  +LV+ A D G+   V +  +++ V+D ND
Sbjct: 2219 ------LFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272

Query: 409  NRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS 468
            NRP I      +    RVSE A  G  +A+V+ +D D                       
Sbjct: 2273 NRPTI-----PQPWELRVSEDALLGSEIAQVTGNDVDS---------------------- 2305

Query: 469  LSLEGGEGDFALLPGGPPGVFFL-------CVEGPLDRESRDLYELLLVATDAGSPPLST 521
                G    + L P GP   F +        + GPLD E  D Y+L L+A D    P   
Sbjct: 2306 ----GPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEG 2358

Query: 522  EETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVV 581
               L + V D+ND  P FSQ  Y+  + E   PG+ ++ VSA+D D   + H        
Sbjct: 2359 RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHI------- 2411

Query: 582  QLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIR---TLDREVQEAVELKVVAQDL 638
                            H A     F++D  +G + TI     L  +   AV++ + A+D 
Sbjct: 2412 --------------SYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDH 2457

Query: 639  GEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
            G P  +A   V + + D ND+ P F    Y   + E  P G   L L
Sbjct: 2458 GAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTL 2504



 Score =  149 bits (377), Expect = 7e-36
 Identities = 177/631 (28%), Positives = 262/631 (41%), Gaps = 108/631 (17%)

Query: 70   TLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTAR 129
            ++ V E +P  TL+  ++A  P A       ++L   +  + LL+     P +G +RTA 
Sbjct: 1861 SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLE-----PSSGELRTAA 1915

Query: 130  RLDRERRDHYSF-------VAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
             LDRE+   Y+F        AA  L   V V I V DVNDH+P FP   L+L    L  P
Sbjct: 1916 ALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRL---RLPRP 1972

Query: 183  GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
            G +F  P           T     ++  D     AG    + YR  G  P    PG++  
Sbjct: 1973 GPSFSTP-----------TLALATLRAEDRD---AGANASILYRLAGTPP----PGTTVD 2014

Query: 243  LEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRR--TGLLSVELRVLDENDNPPVFEQDE 300
                ++ + R           L I A D GRP R  TG++ V L+   E +  P F +  
Sbjct: 2015 SYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQ--GEAERGPRFPRAS 2072

Query: 301  YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
              A +RE+A PG  +   RA     G NG + YS+ +    G             F+++ 
Sbjct: 2073 SEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGT------------FSIQP 2119

Query: 361  LSGV--VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI----H 414
             +G   VR    LD E     +LV++A  GGA    A   +++ + D NDN P      +
Sbjct: 2120 STGAITVRSAEGLDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHY 2176

Query: 415  VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG 474
            V FL E   +R  EG      + +V   D D       + +G        G IS SL   
Sbjct: 2177 VAFLPE---SRPLEGP-----LLQVEADDLD-------QGSG--------GQISYSLAAS 2213

Query: 475  EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLND 534
            +    L    P     +     LDRE      L+L+ATD GSP L    TL + V D ND
Sbjct: 2214 QPARGLFHVDPT-TGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272

Query: 535  QPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQS 594
              P   Q  ++  VSE A  G+ +  V+ +D D        + + V+  S P +      
Sbjct: 2273 NRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGP-----VLWYVLSPSGPQD------ 2320

Query: 595  KMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
                       F++    G +S    LD E  +  +L+++A D    P      +++ V+
Sbjct: 2321 ----------PFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPHEGRANLTVLVE 2367

Query: 655  DVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
            DVNDN P F + +Y   + EH P G   L +
Sbjct: 2368 DVNDNAPAFSQSLYQVMLLEHTPPGSAILSV 2398



 Score =  149 bits (375), Expect = 1e-35
 Identities = 169/663 (25%), Positives = 252/663 (38%), Gaps = 103/663 (15%)

Query: 39   SGARTQRSLLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEG 98
            SG+   R+    ++HV        +A  F+  L   E LP   L G     + A    +G
Sbjct: 447  SGSPPLRAEAAFVLHV---TDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQG 503

Query: 99   SGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV------VQ 152
            +   ++           F + P +GII TA  LD E       +     G +        
Sbjct: 504  TNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSAT 563

Query: 153  VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDL 212
            V + + DVND+ P+F        + E + PGT F    A D D+G               
Sbjct: 564  VSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSG--------------- 608

Query: 213  PKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEA-AAHRLQIEAWDG 271
                  PF  L Y     L S   P         D+   R LDR++  ++    + A DG
Sbjct: 609  ------PFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDG 662

Query: 272  GRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFV 331
            G  +   ++ V++ + DENDNPP F   EY A++   + PG  V R+RA D D G +G +
Sbjct: 663  GGLK--SMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRL 720

Query: 332  RYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE 391
             Y + A   P              F ++E SG++ V  PL R A +  QL + A DGG  
Sbjct: 721  SYHILAGNSP------------PLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGL 768

Query: 392  PEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKE 451
                + RV I+++      P    L      V  V E   PG  V  V   +  G     
Sbjct: 769  QAEPSARVDISIVPGTPTPPIFEQLQY----VFSVPEDVAPGTSVGIVQAHNPPGRL--- 821

Query: 452  DEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFL-CVEG------PLDRESRDL 504
                           ++LSL GG+         P G+F L  V G      PLDRE    
Sbjct: 822  -------------APVTLSLSGGD---------PRGLFSLDAVSGLLQTLRPLDRELLGP 859

Query: 505  YELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSAS 564
               L V   +G PP      + + + D+ND  P F        +    APGT +  + A 
Sbjct: 860  VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRAL 919

Query: 565  DADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDRE 624
            D D   +    + +T++                  A  G +F +D  +G +  +R L   
Sbjct: 920  DPDSGVNSR--VTFTLL------------------AGGGGAFTVDPTTGHVRLMRPLGPS 959

Query: 625  VQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDN--EPIFWRQVYNATIAEHAPVGHCF 682
               A EL++ A+D G PP ++   + + V DV      P F    Y   +      G   
Sbjct: 960  GGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQV 1019

Query: 683  LQL 685
            LQ+
Sbjct: 1020 LQV 1022



 Score =  144 bits (363), Expect = 3e-34
 Identities = 161/597 (26%), Positives = 235/597 (39%), Gaps = 90/597 (15%)

Query: 106  DSDDSPLL----------DDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLG---AVVQ 152
            D D  P+L          D F V    G +     LD E+ D Y        G       
Sbjct: 2302 DVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRAN 2361

Query: 153  VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSD- 211
            + + V DVND++P F     Q+ + E +PPG+A     A D D+G      Y L  P+D 
Sbjct: 2362 LTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG 2421

Query: 212  LPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDG 271
               DP            G L                +V    L  + + A  + +EA D 
Sbjct: 2422 FSVDPNN----------GTL--------------FTIVGTVALGHDGSGAVDVVLEARDH 2457

Query: 272  GRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLG-PNGF 330
            G P R    +V +++ D+ND+ P F    YR AV ED  PG+ +  + ATD D    +  
Sbjct: 2458 GAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAA 2517

Query: 331  VRYSV------RARQV-PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVV 383
            V YS+      R  Q+ P     G + G           G + +  PLD E+   + L V
Sbjct: 2518 VDYSIISGNWGRVFQLEPRLAEAGESAGPGP-----RALGCLVLLEPLDFESLTQYNLTV 2572

Query: 384  EARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSD 443
             A D G  P+ + V V++ VLDVNDN P    +F        V E    G  +  V  SD
Sbjct: 2573 AAADRGQPPQSSVVPVTVTVLDVNDNPP----VFTRASYRVTVPEDTPVGAELLHVEASD 2628

Query: 444  ADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRD 503
            AD              V  GD S    L+   G   L                LD E++ 
Sbjct: 2629 ADPG----PHGLVRFTVSSGDPSGLFELDESSGTLRLAHA-------------LDCETQA 2671

Query: 504  LYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSA 563
             ++L++ A D      +    + + V D+ND  P F       SV+E   PGT+V  + A
Sbjct: 2672 RHQLVVQAADPAGAHFALAP-VTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHA 2730

Query: 564  SDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDR 623
             D D        LRY++++                  E   +FA++S +G +      D 
Sbjct: 2731 IDGDAGAFGR--LRYSLLEAGPG-------------PEGREAFALNSSTGELRARVPFDY 2775

Query: 624  EVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGH 680
            E  E+  L V A D G   LSA+  VS+ V   ++ +P+F    ++  + E A  GH
Sbjct: 2776 EHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGH 2830



 Score =  141 bits (356), Expect = 2e-33
 Identities = 170/617 (27%), Positives = 246/617 (39%), Gaps = 138/617 (22%)

Query: 72   SVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRL 131
            SV E + P T VG ++A  P  +    +   LS    D   L  F +   +G+++T R L
Sbjct: 798  SVPEDVAPGTSVGIVQAHNPPGRLAPVT---LSLSGGDPRGL--FSLDAVSGLLQTLRPL 852

Query: 132  DRERRDHYSFVAATLLGAVVQVEIR-----------------VNDVNDHSPRFPLDSLQL 174
            DRE           LLG V+++E+R                 ++DVND+SP FP     +
Sbjct: 853  DRE-----------LLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTV 901

Query: 175  DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSP 234
             +   + PGT      A DPD+G+ S   +TL+                           
Sbjct: 902  LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG------------------------ 937

Query: 235  LLPGSSSPLEPLD--LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
               G +  ++P    + L+R L      AH L++EA DGG P RT    + + V D    
Sbjct: 938  ---GGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTR 994

Query: 293  --PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL 350
               P F    YR  +      G +V +V+A   D GP   + Y + A             
Sbjct: 995  GLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAE------------ 1039

Query: 351  GDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDG-----GAEPEVATVRVSIAVLD 405
            G ++ F +E  SG + V   LDREAQ  + L V A  G     G +   ATVRVSI  L+
Sbjct: 1040 GASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSI--LN 1097

Query: 406  VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGL--- 462
             N++ P +      +     V+E   PG  V RV  +D D          G L   L   
Sbjct: 1098 QNEHSPRLS----EDPTFLAVAENQPPGTSVGRVFATDRDSG------PNGRLTYSLQQL 1147

Query: 463  GDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
             + S +  +    G+   L               LDRE +  Y+LL+   D GSPP ST 
Sbjct: 1148 SEDSKAFRIHPQTGEVTTLQ-------------TLDREQQSSYQLLVQVQDGGSPPRSTT 1194

Query: 523  ETLLLRVADLNDQPPLFSQQHYKA------SVSEAAAPGTVVMWVSASDADEAGSDHAWL 576
             T+ + V DLND  P F Q    A       V +   PGT+V  + A D DE   ++  +
Sbjct: 1195 GTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDE--GENGTI 1252

Query: 577  RYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQ 636
             YT+                  T      F++   SG + T   L R  +    L + A 
Sbjct: 1253 LYTL------------------TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAH 1294

Query: 637  DLGEPPLSATCLVSITV 653
            D G PP SA+  + + V
Sbjct: 1295 DQGSPPRSASLQLLVQV 1311



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 58/199 (29%), Positives = 84/199 (42%), Gaps = 32/199 (16%)

Query: 497 LDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGT 556
           LDRE RD Y    V  D  +  ++      +RVAD+ND  P F Q      V E  A GT
Sbjct: 107 LDREQRDRYRFTAVTPDGATVEVT------VRVADINDHAPAFPQARAALQVPEHTAFGT 160

Query: 557 VVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIS 616
                 A DAD                     LG+ Q   +     G +F +++  G   
Sbjct: 161 RYPLEPARDADAG------------------RLGT-QGYALSGDGAGETFRLETRPGPDG 201

Query: 617 T-------IRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYN 669
           T          LDRE +    L++ A D G PP  A  L+ +T+ D+ND+ P F +  Y+
Sbjct: 202 TPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYH 261

Query: 670 ATIAEHAPVGHCFLQLISA 688
           A ++E    G   LQ+ ++
Sbjct: 262 AVVSESLAPGSPVLQVFAS 280



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 39/154 (25%), Positives = 58/154 (37%), Gaps = 4/154 (2%)

Query: 61   GSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHP 120
            G +  L  L+ SV E  PP TLV  + A    A       + L E        + F ++ 
Sbjct: 2703 GPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNS 2762

Query: 121  DTGIIRTARRLDRERRDHYSFVA----ATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDV 176
             TG +R     D E  + +  +     A  L A V V + V   +++ P F   +    V
Sbjct: 2763 STGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQV 2822

Query: 177  SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
             E +  G +     A D D G      Y+L   S
Sbjct: 2823 PEGARRGHSLGHVQATDEDGGADGLVLYSLATSS 2856


>gi|94538350 protocadherin 17 precursor [Homo sapiens]
          Length = 1159

 Score =  262 bits (670), Expect = 7e-70
 Identities = 200/624 (32%), Positives = 313/624 (50%), Gaps = 69/624 (11%)

Query: 56  LWAASGSSAQLFNLTLSVDEGLPPDTLVGDI------RAGLPAAQQQEG----SGFFLSE 105
           LWA +     L NL  SV E     T++G+I      + GLP A++  G    SG +   
Sbjct: 11  LWAPA---LTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVL 67

Query: 106 DSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGA------VVQVEIRVND 159
           ++    LLD   V  D+G++ T +R+DRE    ++      L        +  +++ + D
Sbjct: 68  ENSAPHLLD---VDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQD 124

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           +ND++P F  D +++D+SE + PGT F L  AHDPDAG    + Y L       +D  G 
Sbjct: 125 INDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLT------RDDHG- 177

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL 279
            F L  ++ G        G+  P    +LV+ + LDRE+   H L + A DGG P R+  
Sbjct: 178 LFGLDVKSRGD-------GTKFP----ELVIQKALDREQQNHHTLVLTALDGGEPPRSAT 226

Query: 280 LSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQ 339
           + + ++V+D NDN PVFE   Y   + E+A  G  V  + ATD D GPNG V YS  +  
Sbjct: 227 VQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSF-SSY 285

Query: 340 VPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRV 399
           VP              F+++  +G++RV   LD E     ++ V+ARD G  P  A  +V
Sbjct: 286 VPDR--------VRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKV 337

Query: 400 SIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELG 459
           ++ ++D NDN P+I  + + +G    +SE A PG  +A V V+D D     + +     G
Sbjct: 338 TVKLIDRNDNAPSIGFVSVRQGA---LSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGG 394

Query: 460 VGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPL 519
            G G G   L   GG   F  L       + +  + PLDRE++D Y + +VA D GSPPL
Sbjct: 395 GGTGGGG-GLGGPGGSVPFK-LEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPL 452

Query: 520 STEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYT 579
           ++ ++  +++ D ND PP F++  Y   V E   PG  +  V A D D     +  + Y+
Sbjct: 453 NSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDL--GQNGTVSYS 510

Query: 580 VVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLG 639
           ++    P ++G +    ++T       +++  +GAI  +R+ + E  +A E KV+A+D G
Sbjct: 511 IL----PSHIGDVS---IYT-----YVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSG 558

Query: 640 EPP-LSATCLVSITVDDVNDNEPI 662
            P  L +   V +TV DVNDN P+
Sbjct: 559 APAHLESNATVRVTVLDVNDNAPV 582



 Score =  144 bits (364), Expect = 2e-34
 Identities = 155/546 (28%), Positives = 225/546 (41%), Gaps = 86/546 (15%)

Query: 129 RRLDRERRDHYSFVAATLLG------AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           + LDRE+++H++ V   L G      A VQ+ ++V D ND+SP F   S  +++ E +P 
Sbjct: 199 KALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPL 258

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           GT      A D D G     G  L   S    D     F +  +T               
Sbjct: 259 GTVVIDLNATDADEG---PNGEVLYSFSSYVPDRVRELFSIDPKT--------------- 300

Query: 243 LEPLDLVLLR-RLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
                L+ ++  LD EE     + ++A D G         V ++++D NDN P       
Sbjct: 301 ----GLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSV 356

Query: 302 R-AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
           R  A+ E A PG  +  VR TDRD G NG ++  V      G G G G  G +  F +EE
Sbjct: 357 RQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEE 416

Query: 361 LSG---VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417
                  V   RPLDRE Q  + + + ARDGG+ P  +T   +I +LD NDN P      
Sbjct: 417 NYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRF---- 472

Query: 418 LTEG-GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLG-DGSISLSLE--- 472
            T+G  V +V E   PG+Y+  V   D D                LG +G++S S+    
Sbjct: 473 -TKGLYVLQVHENNIPGEYLGSVLAQDPD----------------LGQNGTVSYSILPSH 515

Query: 473 -GGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPP-LSTEETLLLRVA 530
            G    +  +   P       +    + E    +E  ++A D+G+P  L +  T+ + V 
Sbjct: 516 IGDVSIYTYVSVNPTNGAIYALRS-FNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVL 574

Query: 531 DLNDQPPLFSQQHYKASVSEAAAP-----GTVVMWVSASDADEAGSDHAWLRYTVVQLSA 585
           D+ND  P+      +   +E   P     G +V  V A D+D   S    L Y +V    
Sbjct: 575 DVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGR--LTYEIVD--- 629

Query: 586 PCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSA 645
                               F ID  SG I T+     +V   VEL V   D G+P LSA
Sbjct: 630 --------------GNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSA 675

Query: 646 TCLVSI 651
              + I
Sbjct: 676 VAKLII 681



 Score =  134 bits (338), Expect = 2e-31
 Identities = 118/444 (26%), Positives = 185/444 (41%), Gaps = 67/444 (15%)

Query: 252 RRLDREEAAAH----RLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVRE 307
           +R+DRE    H    +L +E +   +     +  +++ + D NDN P F  D+    + E
Sbjct: 88  QRIDRESLCRHNAKCQLSLEVFANDKE----ICMIKVEIQDINDNAPSFSSDQIEMDISE 143

Query: 308 DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367
           +A PG       A D D G NG   Y +        G    + GD   F        + +
Sbjct: 144 NAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPE------LVI 197

Query: 368 WRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVS 427
            + LDRE Q  H LV+ A DGG  P  ATV++++ V+D NDN P    +F     +  + 
Sbjct: 198 QKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSP----VFEAPSYLVELP 253

Query: 428 EGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL-LPGGPP 486
           E A  G  V  ++ +DAD                  +G +  S      D    L    P
Sbjct: 254 ENAPLGTVVIDLNATDADEG---------------PNGEVLYSFSSYVPDRVRELFSIDP 298

Query: 487 GVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYK- 545
               + V+G LD E   + E+ + A D G  P+     + +++ D ND  P       + 
Sbjct: 299 KTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQ 358

Query: 546 ASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS 605
            ++SEAA PGTV+  V  +D D   +                  G LQ +++     G  
Sbjct: 359 GALSEAAPPGTVIALVRVTDRDSGKN------------------GQLQCRVLGGGGTGGG 400

Query: 606 FAIDSESGAIS--------------TIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSI 651
             +    G++               T R LDRE Q+   + +VA+D G PPL++T   +I
Sbjct: 401 GGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAI 460

Query: 652 TVDDVNDNEPIFWRQVYNATIAEH 675
            + D NDN P F + +Y   + E+
Sbjct: 461 KILDENDNPPRFTKGLYVLQVHEN 484



 Score =  117 bits (294), Expect = 3e-26
 Identities = 138/472 (29%), Positives = 193/472 (40%), Gaps = 61/472 (12%)

Query: 77  LPPDTLVGDIRAGLPAAQQQEG-SGFFLSEDSDDSP--LLDDFHVHPDTGIIRTARRLDR 133
           LP +  +G +   L A    EG +G  L   S   P  + + F + P TG+IR    LD 
Sbjct: 252 LPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDY 311

Query: 134 ERRDHYSF-VAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSL-QLDVSELSPPGTAF 186
           E        V A  LG     A  +V +++ D ND++P     S+ Q  +SE +PPGT  
Sbjct: 312 EENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVI 371

Query: 187 RLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL 246
            L    D D+G         +Q   L     G          G L  P   G S P +  
Sbjct: 372 ALVRVTDRDSGKNGQ-----LQCRVLGGGGTGG--------GGGLGGP---GGSVPFKLE 415

Query: 247 D-------LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQD 299
           +       +V  R LDRE    + + I A DGG P      S  +++LDENDNPP F + 
Sbjct: 416 ENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKG 475

Query: 300 EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVE 359
            Y   V E+  PG  +  V A D DLG NG V YS+    +       G +    Y +V 
Sbjct: 476 LYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHI-------GDVSIYTYVSVN 528

Query: 360 ELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV---ATVRVSIAVLDVNDNRPAIHVL 416
             +G +   R  + E     +  V A+D GA   +   ATVRV+  VLDVNDN P I VL
Sbjct: 529 PTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVT--VLDVNDNAPVI-VL 585

Query: 417 FLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEG 476
              +   A +      G      +V   D D+ +    T E+  G  D    +    GE 
Sbjct: 586 PTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGE- 644

Query: 477 DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLR 528
                         +    P   +   + EL++  TD G P LS    L++R
Sbjct: 645 --------------IRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIR 682



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 55/159 (34%), Positives = 72/159 (45%), Gaps = 13/159 (8%)

Query: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
           + + D+ND  P FS    +  +SE AAPGT     SA D D AG +   LR T +     
Sbjct: 120 VEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPD-AGENG--LR-TYLLTRDD 175

Query: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646
             L  L  K        P   I          + LDRE Q    L + A D GEPP SAT
Sbjct: 176 HGLFGLDVKSRGDGTKFPELVIQ---------KALDREQQNHHTLVLTALDGGEPPRSAT 226

Query: 647 CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
             +++ V D NDN P+F    Y   + E+AP+G   + L
Sbjct: 227 VQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDL 265



 Score = 37.7 bits (86), Expect = 0.037
 Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 12/81 (14%)

Query: 608 IDSESGAISTIRTLDRE------VQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
           +D++SG + T + +DRE       +  + L+V A D         C++ + + D+NDN P
Sbjct: 77  VDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFAND------KEICMIKVEIQDINDNAP 130

Query: 662 IFWRQVYNATIAEHAPVGHCF 682
            F        I+E+A  G  F
Sbjct: 131 SFSSDQIEMDISENAAPGTRF 151


>gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor
           [Homo sapiens]
          Length = 1007

 Score =  262 bits (670), Expect = 7e-70
 Identities = 214/666 (32%), Positives = 319/666 (47%), Gaps = 91/666 (13%)

Query: 42  RTQRSLLWLLVH----VWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQE 97
           R +R + WLL+     + L    G +A    L  SV E   P  LVG++   L    ++ 
Sbjct: 15  RLRRPMPWLLLLPLLLLLLLLLPGPAAS--QLRYSVPEEQAPGALVGNVARALGLELRRL 72

Query: 98  GSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRE---RRDHYSFVAATLLG----AV 150
           G G  L  +   +P      +   +G +    R+DRE    +     ++  +L     AV
Sbjct: 73  GPGC-LRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAV 131

Query: 151 VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
             VE+ + D+ND+SPRFP  + QL VSE   PG  F +  A DPD G  S Q Y L  PS
Sbjct: 132 SAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYEL-SPS 190

Query: 211 DLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD 270
           +         F+L  +       PL   S    + L+LVL + LDRE+AA H L + A D
Sbjct: 191 E--------HFELDLK-------PLQENS----KVLELVLRKGLDREQAALHHLVLTAVD 231

Query: 271 GGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGF 330
           GG P R+G   + +RVLD NDN P F+Q  YR  +RED+ PG  V ++ A+D D G NG 
Sbjct: 232 GGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGE 291

Query: 331 VRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGA 390
           +RYS+         S   +  +   F+++  +G VRV   LD E  + +Q+ V+A D G 
Sbjct: 292 LRYSL---------SSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGP 342

Query: 391 EPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEK 450
            P     +V + ++DVNDN P + +  L     + V E A P   VA +SV+D D    +
Sbjct: 343 VPMAGHCKVLVDIVDVNDNAPEVVLTDL----YSPVPENATPNTIVAVLSVNDQDSGPNR 398

Query: 451 EDEATGELGVGLGDGSISLSLEGGEGDFALLP---GGPPGVFFLCVEGPLDRESRDLYEL 507
           +               +SL LE      A LP    G    + L V GPLDRE   +Y +
Sbjct: 399 K---------------VSLGLE------ATLPFRLNGFGNSYTLVVSGPLDRERVAVYNI 437

Query: 508 LLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDAD 567
            + ATD G P L++  TL + ++D+ND PP F +  Y   + E   PG ++  V A+D D
Sbjct: 438 TVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPD 497

Query: 568 EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQE 627
           E   ++A + Y            SL  + +         +I+S SG++  + + D E   
Sbjct: 498 E--KENAEVTY------------SLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFR 543

Query: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP-IFWRQVYNATIA-----EHAPVGHC 681
              + V AQD G PPLS+T   ++ V D+ND+ P I +    N++ A       AP G+ 
Sbjct: 544 EFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYL 603

Query: 682 FLQLIS 687
             ++I+
Sbjct: 604 VTKVIA 609



 Score =  138 bits (348), Expect = 2e-32
 Identities = 149/548 (27%), Positives = 226/548 (41%), Gaps = 103/548 (18%)

Query: 131 LDRERRDHYSFVAATLLGAV------VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE+   +  V   + G +       Q+ +RV D ND+SP F   + ++ + E SPPGT
Sbjct: 215 LDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGT 274

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
                 A DPD G      Y+L   S    D     F +   T                 
Sbjct: 275 LVVKLNASDPDEGSNGELRYSL---SSYTSDRERQLFSIDASTG---------------- 315

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
             ++ ++  LD EEA+++++ ++A D G     G   V + ++D NDN P     +  + 
Sbjct: 316 --EVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP 373

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           V E+A P   V  +   D+D GPN  V   + A  +P   +G G             S  
Sbjct: 374 VPENATPNTIVAVLSVNDQDSGPNRKVSLGLEAT-LPFRLNGFGN------------SYT 420

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVR-VSIAVLDVNDNRPAIHVLFLTEGGV 423
           + V  PLDRE  A + + V A DGG  P++ ++R + + + D+NDN P+    FL +   
Sbjct: 421 LVVSGPLDRERVAVYNITVTATDGGI-PQLTSLRTLKVEISDINDNPPS----FLEDSYS 475

Query: 424 ARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS-------LSLEGGEG 476
             + E   PG  +  V  +D D   EKE+    E+   L +  I        +S+    G
Sbjct: 476 IYIQENNLPGVLLCTVQATDPD---EKEN---AEVTYSLLEREIQGLPVTSYVSINSASG 529

Query: 477 DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
                         L      D E    + + + A D GSPPLS+  T  + V D+ND  
Sbjct: 530 S-------------LYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHA 576

Query: 537 PLFSQQHYKASVSEAAA---------PGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPC 587
           P      Y  S + +AA          G +V  V A D+D     +AWL Y + Q S   
Sbjct: 577 PHIL---YPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSG--QNAWLFYHLAQTSDL- 630

Query: 588 NLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATC 647
                             F ++  +G I T R +  E      L VV +D GEP LSA+ 
Sbjct: 631 ----------------DLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASV 674

Query: 648 LVSITVDD 655
            +++ V D
Sbjct: 675 AITVAVVD 682


>gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor
           [Homo sapiens]
          Length = 884

 Score =  262 bits (670), Expect = 7e-70
 Identities = 214/666 (32%), Positives = 319/666 (47%), Gaps = 91/666 (13%)

Query: 42  RTQRSLLWLLVH----VWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQE 97
           R +R + WLL+     + L    G +A    L  SV E   P  LVG++   L    ++ 
Sbjct: 15  RLRRPMPWLLLLPLLLLLLLLLPGPAAS--QLRYSVPEEQAPGALVGNVARALGLELRRL 72

Query: 98  GSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRE---RRDHYSFVAATLLG----AV 150
           G G  L  +   +P      +   +G +    R+DRE    +     ++  +L     AV
Sbjct: 73  GPGC-LRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAV 131

Query: 151 VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
             VE+ + D+ND+SPRFP  + QL VSE   PG  F +  A DPD G  S Q Y L  PS
Sbjct: 132 SAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYEL-SPS 190

Query: 211 DLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD 270
           +         F+L  +       PL   S    + L+LVL + LDRE+AA H L + A D
Sbjct: 191 E--------HFELDLK-------PLQENS----KVLELVLRKGLDREQAALHHLVLTAVD 231

Query: 271 GGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGF 330
           GG P R+G   + +RVLD NDN P F+Q  YR  +RED+ PG  V ++ A+D D G NG 
Sbjct: 232 GGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGE 291

Query: 331 VRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGA 390
           +RYS+         S   +  +   F+++  +G VRV   LD E  + +Q+ V+A D G 
Sbjct: 292 LRYSL---------SSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGP 342

Query: 391 EPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEK 450
            P     +V + ++DVNDN P + +  L     + V E A P   VA +SV+D D    +
Sbjct: 343 VPMAGHCKVLVDIVDVNDNAPEVVLTDL----YSPVPENATPNTIVAVLSVNDQDSGPNR 398

Query: 451 EDEATGELGVGLGDGSISLSLEGGEGDFALLP---GGPPGVFFLCVEGPLDRESRDLYEL 507
           +               +SL LE      A LP    G    + L V GPLDRE   +Y +
Sbjct: 399 K---------------VSLGLE------ATLPFRLNGFGNSYTLVVSGPLDRERVAVYNI 437

Query: 508 LLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDAD 567
            + ATD G P L++  TL + ++D+ND PP F +  Y   + E   PG ++  V A+D D
Sbjct: 438 TVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPD 497

Query: 568 EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQE 627
           E   ++A + Y            SL  + +         +I+S SG++  + + D E   
Sbjct: 498 E--KENAEVTY------------SLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFR 543

Query: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP-IFWRQVYNATIA-----EHAPVGHC 681
              + V AQD G PPLS+T   ++ V D+ND+ P I +    N++ A       AP G+ 
Sbjct: 544 EFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYL 603

Query: 682 FLQLIS 687
             ++I+
Sbjct: 604 VTKVIA 609



 Score =  138 bits (348), Expect = 2e-32
 Identities = 149/548 (27%), Positives = 226/548 (41%), Gaps = 103/548 (18%)

Query: 131 LDRERRDHYSFVAATLLGAV------VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE+   +  V   + G +       Q+ +RV D ND+SP F   + ++ + E SPPGT
Sbjct: 215 LDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGT 274

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
                 A DPD G      Y+L   S    D     F +   T                 
Sbjct: 275 LVVKLNASDPDEGSNGELRYSL---SSYTSDRERQLFSIDASTG---------------- 315

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
             ++ ++  LD EEA+++++ ++A D G     G   V + ++D NDN P     +  + 
Sbjct: 316 --EVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP 373

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           V E+A P   V  +   D+D GPN  V   + A  +P   +G G             S  
Sbjct: 374 VPENATPNTIVAVLSVNDQDSGPNRKVSLGLEAT-LPFRLNGFGN------------SYT 420

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVR-VSIAVLDVNDNRPAIHVLFLTEGGV 423
           + V  PLDRE  A + + V A DGG  P++ ++R + + + D+NDN P+    FL +   
Sbjct: 421 LVVSGPLDRERVAVYNITVTATDGGI-PQLTSLRTLKVEISDINDNPPS----FLEDSYS 475

Query: 424 ARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS-------LSLEGGEG 476
             + E   PG  +  V  +D D   EKE+    E+   L +  I        +S+    G
Sbjct: 476 IYIQENNLPGVLLCTVQATDPD---EKEN---AEVTYSLLEREIQGLPVTSYVSINSASG 529

Query: 477 DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
                         L      D E    + + + A D GSPPLS+  T  + V D+ND  
Sbjct: 530 S-------------LYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHA 576

Query: 537 PLFSQQHYKASVSEAAA---------PGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPC 587
           P      Y  S + +AA          G +V  V A D+D     +AWL Y + Q S   
Sbjct: 577 PHIL---YPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSG--QNAWLFYHLAQTSDL- 630

Query: 588 NLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATC 647
                             F ++  +G I T R +  E      L VV +D GEP LSA+ 
Sbjct: 631 ----------------DLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASV 674

Query: 648 LVSITVDD 655
            +++ V D
Sbjct: 675 AITVAVVD 682


>gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precursor
           [Homo sapiens]
          Length = 871

 Score =  250 bits (639), Expect = 3e-66
 Identities = 191/604 (31%), Positives = 285/604 (47%), Gaps = 87/604 (14%)

Query: 84  GDIRAGLPAAQQQEGS-------GFFLSEDSDDSPLLD--------DFHVHPDTGIIRTA 128
           G IR  +P  + QEG+        F L  DS  +  L          F V  D+G +   
Sbjct: 29  GQIRYPVPE-ESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIK 87

Query: 129 RRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
             +DRE     S      L  V +        E+ + DVNDH+PRFP   L L++ E +P
Sbjct: 88  NPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAP 147

Query: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
           PG  F L  A D D G  S   Y L        D       ++ R+ G L   LL     
Sbjct: 148 PGQRFPLEKAQDADVGSNSISSYRLSSNEHFALD-------VKKRSDGSLVPELL----- 195

Query: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
                   L + LDRE+ + +RL + A DGG P R+G   + + VLD NDN P F+Q  Y
Sbjct: 196 --------LEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 247

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
           R +V E A  G  + ++ A+D DLGP+G V +           SG         F++   
Sbjct: 248 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYF---------SGHTPDRVRNLFSLHPT 298

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +G + +  PLD E++ +++  V ARDGG+        + + +LDVNDN P I V      
Sbjct: 299 TGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVT----S 354

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
            +  + E A PG  VA +SV D D                  +G +SL +      FAL 
Sbjct: 355 ELGTLPESAEPGTVVALISVQDPDSG---------------SNGDVSLRIPD-HLPFAL- 397

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
                  F L   GPLDRE++  Y++++ A+DAG+PPLST  T+ L ++D+ND PP F Q
Sbjct: 398 KSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQ 457

Query: 542 QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
           + ++  V E   PG ++  ++ASD D     +A + Y++++   P N     S  +    
Sbjct: 458 RSHEVFVPENNRPGDLLCSLAASDPD--SGLNALISYSLLE---PRNRDVSASSFI---- 508

Query: 602 CGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
                +++ ++GA+   R+ D E  + ++ +V A+D G PPLS+T  V + V D+NDN P
Sbjct: 509 -----SLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAP 563

Query: 662 IFWR 665
              R
Sbjct: 564 AVLR 567



 Score =  138 bits (348), Expect = 2e-32
 Identities = 116/419 (27%), Positives = 179/419 (42%), Gaps = 71/419 (16%)

Query: 283 ELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPG 342
           E+ ++D ND+ P F + +    + E A PG      +A D D+G N    Y + + +   
Sbjct: 120 EVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNE--- 176

Query: 343 AGSGGGALGDAAYFAVE-------ELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVA 395
                       +FA++        L   + + +PLDRE Q+ ++LV+ A DGG  P   
Sbjct: 177 ------------HFALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSG 224

Query: 396 TVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEAT 455
           T  + ++VLDVNDN PA    F        V E A  G  + +++ SD D          
Sbjct: 225 TAELRVSVLDVNDNAPA----FQQSSYRISVLESAPAGMVLIQLNASDPD---------- 270

Query: 456 GELGVGLG-DGSISLSLEGGEGD-----FALLPGGPPGVFFLCVEGPLDRESRDLYELLL 509
                 LG  G+++    G   D     F+L P        L + GPLD ES + YE  +
Sbjct: 271 ------LGPSGNVTFYFSGHTPDRVRNLFSLHPTTGK----LTLLGPLDFESENYYEFDV 320

Query: 510 VATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEA 569
            A D GSP +    +L + + D+ND  P  +      ++ E+A PGTVV  +S  D D  
Sbjct: 321 RARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSG 380

Query: 570 GSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAV 629
            +    LR   +    P  L S           GP                LDRE + + 
Sbjct: 381 SNGDVSLR---IPDHLPFALKSAFRNQFSLVTAGP----------------LDREAKSSY 421

Query: 630 ELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISA 688
           ++ V A D G PPLS    + + + DVNDN P F+++ +   + E+   G     L ++
Sbjct: 422 DIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAAS 480



 Score =  127 bits (319), Expect = 4e-29
 Identities = 149/549 (27%), Positives = 219/549 (39%), Gaps = 91/549 (16%)

Query: 71  LSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARR 130
           +SV E  P   ++  + A  P         F+ S  + D  + + F +HP TG +     
Sbjct: 249 ISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDR-VRNLFSLHPTTGKLTLLGP 307

Query: 131 LDRERRDHYSFVAATLLGAVVQVE----IRVN--DVNDHSPRFPLDSLQLDVSELSPPGT 184
           LD E  ++Y F      G    +E    +RV+  DVND++P   + S    + E + PGT
Sbjct: 308 LDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGT 367

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
              L    DPD+G  S    +L  P  LP       F L+               S+   
Sbjct: 368 VVALISVQDPDSG--SNGDVSLRIPDHLP-------FALK---------------SAFRN 403

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
              LV    LDRE  +++ + + A D G P  +   ++ L + D NDNPP F Q  +   
Sbjct: 404 QFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVF 463

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSV---RARQVPGAGSGGGALGDAAYFAVEEL 361
           V E+ +PG  +C + A+D D G N  + YS+   R R V  +          ++ ++   
Sbjct: 464 VPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSAS----------SFISLNPQ 513

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +G V   R  D E     Q  V+ARD G  P  +TV V + VLD+NDN PA+       G
Sbjct: 514 TGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPG 573

Query: 422 GVA--RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFA 479
            +    +      G  + +V+  D D  +               +  +S  L        
Sbjct: 574 SLCPQALPPSVGAGHLITKVTAVDLDSGY---------------NAWVSYQLLEAPDPSL 618

Query: 480 LLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLF 539
                  G     V  P D   +   +L++V  D+GSPPLST  TLL+            
Sbjct: 619 FAVSRYAGEVRTAVPIPADLPPQ---KLVIVVKDSGSPPLSTSVTLLV------------ 663

Query: 540 SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPC--NLGS---LQS 594
                  S+ E   P  VV  +  S A   G     L Y  V L A C  + GS   L S
Sbjct: 664 -------SLEEDTHP--VVPDLRESSAPREGESRLTL-YLAVSLVAICFVSFGSFVALLS 713

Query: 595 KMVHTAECG 603
           K +  A CG
Sbjct: 714 KCLRGAACG 722



 Score =  124 bits (311), Expect = 3e-28
 Identities = 142/550 (25%), Positives = 211/550 (38%), Gaps = 95/550 (17%)

Query: 131 LDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE++  Y  V   + G         ++ + V DVND++P F   S ++ V E +P G 
Sbjct: 200 LDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGM 259

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
                 A DPD G     G      S    D     F L   T                 
Sbjct: 260 VLIQLNASDPDLG---PSGNVTFYFSGHTPDRVRNLFSLHPTTG---------------- 300

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
              L LL  LD E    +   + A DGG P      S+ + +LD NDN P          
Sbjct: 301 --KLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGT 358

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           + E A+PG  V  +   D D G NG V   +              L  A   A      +
Sbjct: 359 LPESAEPGTVVALISVQDPDSGSNGDVSLRIPDH-----------LPFALKSAFRNQFSL 407

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVA 424
           V    PLDREA++ + ++V A D G  P      + + + DVNDN P+    F       
Sbjct: 408 VTAG-PLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPS----FFQRSHEV 462

Query: 425 RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSL------EGGEGDF 478
            V E  RPGD +  ++ SD D               GL +  IS SL      +     F
Sbjct: 463 FVPENNRPGDLLCSLAASDPDS--------------GL-NALISYSLLEPRNRDVSASSF 507

Query: 479 ALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPL 538
             L    P    +      D E     +  + A D G+PPLS+  T+ L V DLND  P 
Sbjct: 508 ISLN---PQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPA 564

Query: 539 FSQQHYK-ASVSEAAAP-----GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592
             +   +  S+   A P     G ++  V+A D D   +  AW+ Y +++   P      
Sbjct: 565 VLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYN--AWVSYQLLEAPDPS----- 617

Query: 593 QSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSIT 652
                        FA+   +G + T   +  ++    +L +V +D G PPLS +  + ++
Sbjct: 618 ------------LFAVSRYAGEVRTAVPIPADLPPQ-KLVIVVKDSGSPPLSTSVTLLVS 664

Query: 653 VDDVNDNEPI 662
           +++  D  P+
Sbjct: 665 LEE--DTHPV 672


>gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precursor
           [Homo sapiens]
          Length = 938

 Score =  250 bits (639), Expect = 3e-66
 Identities = 191/604 (31%), Positives = 285/604 (47%), Gaps = 87/604 (14%)

Query: 84  GDIRAGLPAAQQQEGS-------GFFLSEDSDDSPLLD--------DFHVHPDTGIIRTA 128
           G IR  +P  + QEG+        F L  DS  +  L          F V  D+G +   
Sbjct: 29  GQIRYPVPE-ESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIK 87

Query: 129 RRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
             +DRE     S      L  V +        E+ + DVNDH+PRFP   L L++ E +P
Sbjct: 88  NPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAP 147

Query: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
           PG  F L  A D D G  S   Y L        D       ++ R+ G L   LL     
Sbjct: 148 PGQRFPLEKAQDADVGSNSISSYRLSSNEHFALD-------VKKRSDGSLVPELL----- 195

Query: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
                   L + LDRE+ + +RL + A DGG P R+G   + + VLD NDN P F+Q  Y
Sbjct: 196 --------LEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 247

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
           R +V E A  G  + ++ A+D DLGP+G V +           SG         F++   
Sbjct: 248 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYF---------SGHTPDRVRNLFSLHPT 298

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +G + +  PLD E++ +++  V ARDGG+        + + +LDVNDN P I V      
Sbjct: 299 TGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVT----S 354

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
            +  + E A PG  VA +SV D D                  +G +SL +      FAL 
Sbjct: 355 ELGTLPESAEPGTVVALISVQDPDSG---------------SNGDVSLRIPD-HLPFAL- 397

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
                  F L   GPLDRE++  Y++++ A+DAG+PPLST  T+ L ++D+ND PP F Q
Sbjct: 398 KSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQ 457

Query: 542 QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
           + ++  V E   PG ++  ++ASD D     +A + Y++++   P N     S  +    
Sbjct: 458 RSHEVFVPENNRPGDLLCSLAASDPD--SGLNALISYSLLE---PRNRDVSASSFI---- 508

Query: 602 CGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
                +++ ++GA+   R+ D E  + ++ +V A+D G PPLS+T  V + V D+NDN P
Sbjct: 509 -----SLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAP 563

Query: 662 IFWR 665
              R
Sbjct: 564 AVLR 567



 Score =  138 bits (348), Expect = 2e-32
 Identities = 116/419 (27%), Positives = 179/419 (42%), Gaps = 71/419 (16%)

Query: 283 ELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPG 342
           E+ ++D ND+ P F + +    + E A PG      +A D D+G N    Y + + +   
Sbjct: 120 EVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNE--- 176

Query: 343 AGSGGGALGDAAYFAVE-------ELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVA 395
                       +FA++        L   + + +PLDRE Q+ ++LV+ A DGG  P   
Sbjct: 177 ------------HFALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSG 224

Query: 396 TVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEAT 455
           T  + ++VLDVNDN PA    F        V E A  G  + +++ SD D          
Sbjct: 225 TAELRVSVLDVNDNAPA----FQQSSYRISVLESAPAGMVLIQLNASDPD---------- 270

Query: 456 GELGVGLG-DGSISLSLEGGEGD-----FALLPGGPPGVFFLCVEGPLDRESRDLYELLL 509
                 LG  G+++    G   D     F+L P        L + GPLD ES + YE  +
Sbjct: 271 ------LGPSGNVTFYFSGHTPDRVRNLFSLHPTTGK----LTLLGPLDFESENYYEFDV 320

Query: 510 VATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEA 569
            A D GSP +    +L + + D+ND  P  +      ++ E+A PGTVV  +S  D D  
Sbjct: 321 RARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSG 380

Query: 570 GSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAV 629
            +    LR   +    P  L S           GP                LDRE + + 
Sbjct: 381 SNGDVSLR---IPDHLPFALKSAFRNQFSLVTAGP----------------LDREAKSSY 421

Query: 630 ELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISA 688
           ++ V A D G PPLS    + + + DVNDN P F+++ +   + E+   G     L ++
Sbjct: 422 DIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAAS 480



 Score =  127 bits (319), Expect = 4e-29
 Identities = 149/549 (27%), Positives = 219/549 (39%), Gaps = 91/549 (16%)

Query: 71  LSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARR 130
           +SV E  P   ++  + A  P         F+ S  + D  + + F +HP TG +     
Sbjct: 249 ISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDR-VRNLFSLHPTTGKLTLLGP 307

Query: 131 LDRERRDHYSFVAATLLGAVVQVE----IRVN--DVNDHSPRFPLDSLQLDVSELSPPGT 184
           LD E  ++Y F      G    +E    +RV+  DVND++P   + S    + E + PGT
Sbjct: 308 LDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGT 367

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
              L    DPD+G  S    +L  P  LP       F L+               S+   
Sbjct: 368 VVALISVQDPDSG--SNGDVSLRIPDHLP-------FALK---------------SAFRN 403

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
              LV    LDRE  +++ + + A D G P  +   ++ L + D NDNPP F Q  +   
Sbjct: 404 QFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVF 463

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSV---RARQVPGAGSGGGALGDAAYFAVEEL 361
           V E+ +PG  +C + A+D D G N  + YS+   R R V  +          ++ ++   
Sbjct: 464 VPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSAS----------SFISLNPQ 513

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +G V   R  D E     Q  V+ARD G  P  +TV V + VLD+NDN PA+       G
Sbjct: 514 TGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPG 573

Query: 422 GVA--RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFA 479
            +    +      G  + +V+  D D  +               +  +S  L        
Sbjct: 574 SLCPQALPPSVGAGHLITKVTAVDLDSGY---------------NAWVSYQLLEAPDPSL 618

Query: 480 LLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLF 539
                  G     V  P D   +   +L++V  D+GSPPLST  TLL+            
Sbjct: 619 FAVSRYAGEVRTAVPIPADLPPQ---KLVIVVKDSGSPPLSTSVTLLV------------ 663

Query: 540 SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPC--NLGS---LQS 594
                  S+ E   P  VV  +  S A   G     L Y  V L A C  + GS   L S
Sbjct: 664 -------SLEEDTHP--VVPDLRESSAPREGESRLTL-YLAVSLVAICFVSFGSFVALLS 713

Query: 595 KMVHTAECG 603
           K +  A CG
Sbjct: 714 KCLRGAACG 722



 Score =  124 bits (311), Expect = 3e-28
 Identities = 142/550 (25%), Positives = 211/550 (38%), Gaps = 95/550 (17%)

Query: 131 LDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE++  Y  V   + G         ++ + V DVND++P F   S ++ V E +P G 
Sbjct: 200 LDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGM 259

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
                 A DPD G     G      S    D     F L   T                 
Sbjct: 260 VLIQLNASDPDLG---PSGNVTFYFSGHTPDRVRNLFSLHPTTG---------------- 300

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
              L LL  LD E    +   + A DGG P      S+ + +LD NDN P          
Sbjct: 301 --KLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGT 358

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           + E A+PG  V  +   D D G NG V   +              L  A   A      +
Sbjct: 359 LPESAEPGTVVALISVQDPDSGSNGDVSLRIPDH-----------LPFALKSAFRNQFSL 407

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVA 424
           V    PLDREA++ + ++V A D G  P      + + + DVNDN P+    F       
Sbjct: 408 VTAG-PLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPS----FFQRSHEV 462

Query: 425 RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSL------EGGEGDF 478
            V E  RPGD +  ++ SD D               GL +  IS SL      +     F
Sbjct: 463 FVPENNRPGDLLCSLAASDPDS--------------GL-NALISYSLLEPRNRDVSASSF 507

Query: 479 ALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPL 538
             L    P    +      D E     +  + A D G+PPLS+  T+ L V DLND  P 
Sbjct: 508 ISLN---PQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPA 564

Query: 539 FSQQHYK-ASVSEAAAP-----GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592
             +   +  S+   A P     G ++  V+A D D   +  AW+ Y +++   P      
Sbjct: 565 VLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYN--AWVSYQLLEAPDPS----- 617

Query: 593 QSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSIT 652
                        FA+   +G + T   +  ++    +L +V +D G PPLS +  + ++
Sbjct: 618 ------------LFAVSRYAGEVRTAVPIPADLPPQ-KLVIVVKDSGSPPLSTSVTLLVS 664

Query: 653 VDDVNDNEPI 662
           +++  D  P+
Sbjct: 665 LEE--DTHPV 672


>gi|11056032 protocadherin gamma subfamily A, 1 isoform 1 precursor
           [Homo sapiens]
          Length = 931

 Score =  250 bits (638), Expect = 4e-66
 Identities = 195/627 (31%), Positives = 288/627 (45%), Gaps = 93/627 (14%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
           LL L + + L A +G      N+  SV E     + VG+I   L    Q+   G      
Sbjct: 15  LLCLSLELLLEAGAG------NIHYSVPEETDKGSFVGNIAKDLGLQPQELADGGVRIVS 68

Query: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVND 159
               PL   F ++P +G + TARR+DRE     S         +V+       VE+ + D
Sbjct: 69  RGRMPL---FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIID 125

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           +ND++P+F L+ L+  ++E++ PGT   LP   D D G+ S Q Y L          + P
Sbjct: 126 INDNTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQL---------SSNP 176

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL 279
            F L  +           G+  P  P ++VL   LDREE A H L + A DGG P R+G 
Sbjct: 177 HFSLDVQQ----------GADGPQHP-EMVLQSPLDREEEAVHHLILTASDGGEPVRSGT 225

Query: 280 LSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV---- 335
           L + ++V+D NDNPP F Q +Y   V E+   G ++  V ATD D G NG V YS     
Sbjct: 226 LRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVD 285

Query: 336 -RARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV 394
            R  Q+               F ++  +G +    PLD E    + + V+A+DG     +
Sbjct: 286 HRVAQI---------------FRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAG--LM 328

Query: 395 ATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEA 454
           A V+V I VLDVNDN P + +  +T      V E   PG  +A +SV D D         
Sbjct: 329 AKVKVLIKVLDVNDNAPEVTITSVT----TAVPENFPPGTIIALISVHDQDS-------- 376

Query: 455 TGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDA 514
                   GD   +     G   F  L       + L  E  LDRE    Y + + A D 
Sbjct: 377 --------GDNGYTTCFIPGNLPFK-LEKLVDNYYRLVTERTLDRELISGYNITITAIDQ 427

Query: 515 GSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
           G+P LSTE  + L V D+ND  P+F Q  Y A + E    G  +  V A D D   +++A
Sbjct: 428 GTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLD--SNENA 485

Query: 575 WLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV 634
            + Y++++              +  A      +I+S++G +  +R+ D E    ++LKV+
Sbjct: 486 QITYSLIE------------DTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVM 533

Query: 635 AQDLGEPPLSATCLVSITVDDVNDNEP 661
           A+D G+PPLS+   +S+ + D NDN P
Sbjct: 534 ARDSGDPPLSSNVSLSLFLLDQNDNAP 560



 Score =  132 bits (333), Expect = 8e-31
 Identities = 119/433 (27%), Positives = 180/433 (41%), Gaps = 49/433 (11%)

Query: 248 LVLLRRLDREEAAAHRLQ-IEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306
           L+  RR+DREE  A  +  + +++     +  L  VE+ ++D NDN P F+ +E    + 
Sbjct: 84  LITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQLEELEFKMN 143

Query: 307 EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
           E   PG  V      D D+G N    Y + +          GA G      V +      
Sbjct: 144 EITTPGTRVSLPFGQDLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQ------ 197

Query: 367 VWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARV 426
              PLDRE +A H L++ A DGG      T+R+ I V+D NDN PA    F        V
Sbjct: 198 --SPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPA----FTQAQYHINV 251

Query: 427 SEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486
            E    G  +  V+ +D D                  +G ++ S    +   A +     
Sbjct: 252 PENVPLGTQLLMVNATDPDEG---------------ANGEVTYSFHNVDHRVAQIFRLDS 296

Query: 487 GVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKA 546
               +  + PLD E   +Y + + A D     L  +  +L++V D+ND  P  +      
Sbjct: 297 YTGEISNKEPLDFEEYKMYSMEVQAQDGAG--LMAKVKVLIKVLDVNDNAPEVTITSVTT 354

Query: 547 SVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSF 606
           +V E   PGT++  +S  D D   +      YT   +  P NL     K+V         
Sbjct: 355 AVPENFPPGTIIALISVHDQDSGDNG-----YTTCFI--PGNLPFKLEKLVDNYY----- 402

Query: 607 AIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666
                   + T RTLDRE+     + + A D G P LS    +S+ V D+NDN P+F + 
Sbjct: 403 -------RLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQD 455

Query: 667 VYNATIAEHAPVG 679
            Y+A I E+ P G
Sbjct: 456 SYSAYIPENNPRG 468



 Score =  121 bits (303), Expect = 3e-27
 Identities = 145/541 (26%), Positives = 218/541 (40%), Gaps = 90/541 (16%)

Query: 131 LDRERRD-HYSFVAAT-----LLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE    H+  + A+     +    +++ I+V D ND+ P F      ++V E  P GT
Sbjct: 200 LDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGT 259

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
              +  A DPD G      Y+              F  + +R           G  S  E
Sbjct: 260 QLLMVNATDPDEGANGEVTYS--------------FHNVDHRVAQIFRLDSYTGEISNKE 305

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS---VELRVLDENDNPPVFEQDEY 301
           PLD         EE   + ++++A DG      GL++   V ++VLD NDN P       
Sbjct: 306 PLDF--------EEYKMYSMEVQAQDGA-----GLMAKVKVLIKVLDVNDNAPEVTITSV 352

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
             AV E+  PG  +  +   D+D G NG+    +    +P        L D  Y  V E 
Sbjct: 353 TTAVPENFPPGTIIALISVHDQDSGDNGYTTCFIPGN-LPFKLE---KLVDNYYRLVTE- 407

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
                  R LDRE  + + + + A D G         +S+ V D+NDN P  H     + 
Sbjct: 408 -------RTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFH----QDS 456

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
             A + E    G  +  V   D D +  +  + T  L        I  +++G      L 
Sbjct: 457 YSAYIPENNPRGASIFSVRAHDLDSN--ENAQITYSL--------IEDTIQGAPLSAYLS 506

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
                GV +       + + RD+ +L ++A D+G PPLS+  +L L + D ND  P    
Sbjct: 507 INSDTGVLYALRSFDYE-QFRDM-QLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILY 564

Query: 542 QHYKASVSE-------AAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQS 594
                  S        +A PG +V  V A D D     +AWL Y +++ S P     L S
Sbjct: 565 PALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSG--QNAWLSYRLLKASEP----GLFS 618

Query: 595 KMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
             +HT E   + A+            LDR+  +   L V  QD G+PPLSAT  +++ V 
Sbjct: 619 VGLHTGEVRTARAL------------LDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVA 665

Query: 655 D 655
           D
Sbjct: 666 D 666



 Score = 30.4 bits (67), Expect = 5.9
 Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 1/61 (1%)

Query: 604 PSFAIDSESGAISTIRTLDREVQEAVELK-VVAQDLGEPPLSATCLVSITVDDVNDNEPI 662
           P FA++  SG++ T R +DRE   A  +  +V+ ++          V + + D+NDN P 
Sbjct: 73  PLFALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQ 132

Query: 663 F 663
           F
Sbjct: 133 F 133


>gi|14196459 protocadherin gamma subfamily A, 1 isoform 2 precursor
           [Homo sapiens]
          Length = 823

 Score =  250 bits (638), Expect = 4e-66
 Identities = 195/627 (31%), Positives = 288/627 (45%), Gaps = 93/627 (14%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
           LL L + + L A +G      N+  SV E     + VG+I   L    Q+   G      
Sbjct: 15  LLCLSLELLLEAGAG------NIHYSVPEETDKGSFVGNIAKDLGLQPQELADGGVRIVS 68

Query: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVND 159
               PL   F ++P +G + TARR+DRE     S         +V+       VE+ + D
Sbjct: 69  RGRMPL---FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIID 125

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           +ND++P+F L+ L+  ++E++ PGT   LP   D D G+ S Q Y L          + P
Sbjct: 126 INDNTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQL---------SSNP 176

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL 279
            F L  +           G+  P  P ++VL   LDREE A H L + A DGG P R+G 
Sbjct: 177 HFSLDVQQ----------GADGPQHP-EMVLQSPLDREEEAVHHLILTASDGGEPVRSGT 225

Query: 280 LSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV---- 335
           L + ++V+D NDNPP F Q +Y   V E+   G ++  V ATD D G NG V YS     
Sbjct: 226 LRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVD 285

Query: 336 -RARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV 394
            R  Q+               F ++  +G +    PLD E    + + V+A+DG     +
Sbjct: 286 HRVAQI---------------FRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAG--LM 328

Query: 395 ATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEA 454
           A V+V I VLDVNDN P + +  +T      V E   PG  +A +SV D D         
Sbjct: 329 AKVKVLIKVLDVNDNAPEVTITSVT----TAVPENFPPGTIIALISVHDQDS-------- 376

Query: 455 TGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDA 514
                   GD   +     G   F  L       + L  E  LDRE    Y + + A D 
Sbjct: 377 --------GDNGYTTCFIPGNLPFK-LEKLVDNYYRLVTERTLDRELISGYNITITAIDQ 427

Query: 515 GSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
           G+P LSTE  + L V D+ND  P+F Q  Y A + E    G  +  V A D D   +++A
Sbjct: 428 GTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLD--SNENA 485

Query: 575 WLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV 634
            + Y++++              +  A      +I+S++G +  +R+ D E    ++LKV+
Sbjct: 486 QITYSLIE------------DTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVM 533

Query: 635 AQDLGEPPLSATCLVSITVDDVNDNEP 661
           A+D G+PPLS+   +S+ + D NDN P
Sbjct: 534 ARDSGDPPLSSNVSLSLFLLDQNDNAP 560



 Score =  132 bits (333), Expect = 8e-31
 Identities = 119/433 (27%), Positives = 180/433 (41%), Gaps = 49/433 (11%)

Query: 248 LVLLRRLDREEAAAHRLQ-IEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306
           L+  RR+DREE  A  +  + +++     +  L  VE+ ++D NDN P F+ +E    + 
Sbjct: 84  LITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQLEELEFKMN 143

Query: 307 EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
           E   PG  V      D D+G N    Y + +          GA G      V +      
Sbjct: 144 EITTPGTRVSLPFGQDLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQ------ 197

Query: 367 VWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARV 426
              PLDRE +A H L++ A DGG      T+R+ I V+D NDN PA    F        V
Sbjct: 198 --SPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPA----FTQAQYHINV 251

Query: 427 SEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486
            E    G  +  V+ +D D                  +G ++ S    +   A +     
Sbjct: 252 PENVPLGTQLLMVNATDPDEG---------------ANGEVTYSFHNVDHRVAQIFRLDS 296

Query: 487 GVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKA 546
               +  + PLD E   +Y + + A D     L  +  +L++V D+ND  P  +      
Sbjct: 297 YTGEISNKEPLDFEEYKMYSMEVQAQDGAG--LMAKVKVLIKVLDVNDNAPEVTITSVTT 354

Query: 547 SVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSF 606
           +V E   PGT++  +S  D D   +      YT   +  P NL     K+V         
Sbjct: 355 AVPENFPPGTIIALISVHDQDSGDNG-----YTTCFI--PGNLPFKLEKLVDNYY----- 402

Query: 607 AIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666
                   + T RTLDRE+     + + A D G P LS    +S+ V D+NDN P+F + 
Sbjct: 403 -------RLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQD 455

Query: 667 VYNATIAEHAPVG 679
            Y+A I E+ P G
Sbjct: 456 SYSAYIPENNPRG 468



 Score =  121 bits (303), Expect = 3e-27
 Identities = 145/541 (26%), Positives = 218/541 (40%), Gaps = 90/541 (16%)

Query: 131 LDRERRD-HYSFVAAT-----LLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE    H+  + A+     +    +++ I+V D ND+ P F      ++V E  P GT
Sbjct: 200 LDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGT 259

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
              +  A DPD G      Y+              F  + +R           G  S  E
Sbjct: 260 QLLMVNATDPDEGANGEVTYS--------------FHNVDHRVAQIFRLDSYTGEISNKE 305

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS---VELRVLDENDNPPVFEQDEY 301
           PLD         EE   + ++++A DG      GL++   V ++VLD NDN P       
Sbjct: 306 PLDF--------EEYKMYSMEVQAQDGA-----GLMAKVKVLIKVLDVNDNAPEVTITSV 352

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
             AV E+  PG  +  +   D+D G NG+    +    +P        L D  Y  V E 
Sbjct: 353 TTAVPENFPPGTIIALISVHDQDSGDNGYTTCFIPGN-LPFKLE---KLVDNYYRLVTE- 407

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
                  R LDRE  + + + + A D G         +S+ V D+NDN P  H     + 
Sbjct: 408 -------RTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFH----QDS 456

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
             A + E    G  +  V   D D +  +  + T  L        I  +++G      L 
Sbjct: 457 YSAYIPENNPRGASIFSVRAHDLDSN--ENAQITYSL--------IEDTIQGAPLSAYLS 506

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
                GV +       + + RD+ +L ++A D+G PPLS+  +L L + D ND  P    
Sbjct: 507 INSDTGVLYALRSFDYE-QFRDM-QLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILY 564

Query: 542 QHYKASVSE-------AAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQS 594
                  S        +A PG +V  V A D D     +AWL Y +++ S P     L S
Sbjct: 565 PALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSG--QNAWLSYRLLKASEP----GLFS 618

Query: 595 KMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
             +HT E   + A+            LDR+  +   L V  QD G+PPLSAT  +++ V 
Sbjct: 619 VGLHTGEVRTARAL------------LDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVA 665

Query: 655 D 655
           D
Sbjct: 666 D 666



 Score = 30.4 bits (67), Expect = 5.9
 Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 1/61 (1%)

Query: 604 PSFAIDSESGAISTIRTLDREVQEAVELK-VVAQDLGEPPLSATCLVSITVDDVNDNEPI 662
           P FA++  SG++ T R +DRE   A  +  +V+ ++          V + + D+NDN P 
Sbjct: 73  PLFALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQ 132

Query: 663 F 663
           F
Sbjct: 133 F 133


>gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precursor
           [Homo sapiens]
          Length = 936

 Score =  246 bits (629), Expect = 4e-65
 Identities = 189/604 (31%), Positives = 287/604 (47%), Gaps = 85/604 (14%)

Query: 69  LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTA 128
           ++ S+ E L   + VG+I   L  A ++             + L   F ++P +G + TA
Sbjct: 35  ISYSIPEELEKGSFVGNISKDLGLAPRELAERGVRIVSRGRTQL---FSLNPRSGSLITA 91

Query: 129 RRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
            R+DRE     S         +V+       +EI V D+ND++P+F  ++L + ++E   
Sbjct: 92  GRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVA 151

Query: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
            G  F LP A DPD G+ S Q Y L              F LR ++            ++
Sbjct: 152 AGMRFPLPEAIDPDVGVNSLQSYQL---------SPNKHFSLRVQS-----------RAN 191

Query: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
            ++  +LVL   LDREE A H L + A DGG P R+G + V + V D NDN PVF   EY
Sbjct: 192 GVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEY 251

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
           R +V E+   G ++  V ATDRD G NG V YS   R++P              F + + 
Sbjct: 252 RVSVPENLPVGTQLLTVTATDRDEGANGEVTYSF--RKLPDT--------QLLKFQLNKY 301

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +G +++   LD E   ++++ ++A DGGA   +AT +V I V DVNDN P + +  L   
Sbjct: 302 TGEIKISENLDYEETGFYEIEIQAEDGGA--YLATAKVLITVEDVNDNSPELTITSL--- 356

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
             + V+E +  G  VA ++V D D +                +G ++ S+       A L
Sbjct: 357 -FSPVTEDSPLGTVVALLNVHDLDSE---------------QNGQVTCSI------LAYL 394

Query: 482 P----GGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
           P          + L +   LDRE    Y + + ATD GSPPLSTE   +L+VAD+ND PP
Sbjct: 395 PFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPP 454

Query: 538 LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
            FSQ  Y   + E  A G  +  V+A D D    ++A + Y            SL    +
Sbjct: 455 TFSQVSYFTYIPENNARGASIFSVTALDPD--SKENAQIIY------------SLAEDTI 500

Query: 598 HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
                    +I+S++G +  +R+ D E    ++++V A D G+PPLS+   +S+ V D N
Sbjct: 501 QGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQN 560

Query: 658 DNEP 661
           DN P
Sbjct: 561 DNAP 564



 Score =  127 bits (318), Expect = 5e-29
 Identities = 145/502 (28%), Positives = 205/502 (40%), Gaps = 81/502 (16%)

Query: 50  LLVHVWLWAASGSSAQLFNLT---LSVDEGLPPDTLVGDIRAGLPAAQQQEGSG---FFL 103
           +LV V ++ A+  +A +F L    +SV E LP    VG     + A  + EG+     + 
Sbjct: 230 VLVSVTVFDAN-DNAPVFTLPEYRVSVPENLP----VGTQLLTVTATDRDEGANGEVTYS 284

Query: 104 SEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLG----AVVQVEIRVND 159
                D+ LL  F ++  TG I+ +  LD E    Y        G    A  +V I V D
Sbjct: 285 FRKLPDTQLLK-FQLNKYTGEIKISENLDYEETGFYEIEIQAEDGGAYLATAKVLITVED 343

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           VND+SP   + SL   V+E SP GT   L   HD D+                  +  G 
Sbjct: 344 VNDNSPELTITSLFSPVTEDSPLGTVVALLNVHDLDS------------------EQNG- 384

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL 279
             Q+       LP  L     S      LV+ R LDRE+ +++ + + A DGG P  +  
Sbjct: 385 --QVTCSILAYLPFKLEKSIDSYYR---LVIHRALDREQVSSYNITVTATDGGSPPLSTE 439

Query: 280 LSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQ 339
               L+V D NDNPP F Q  Y   + E+   GA +  V A D D   N  + YS+    
Sbjct: 440 AHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQIIYSLAEDT 499

Query: 340 VPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRV 399
           + G          ++Y ++   +GV+   R  D E     Q+ V A D G  P  + V +
Sbjct: 500 IQGVPL-------SSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSL 552

Query: 400 SIAVLDVNDNRPAI-HVLFLTEG--GVARVSEGARPGDYVARVSVSDADGDWEKEDEATG 456
           S+ VLD NDN P I +    T+G  GV      A PG  V +V   D D           
Sbjct: 553 SLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRD----------- 601

Query: 457 ELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYE-------LLL 509
                        S +     + LL    PG+F +       R +R L +       L++
Sbjct: 602 -------------SGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVV 648

Query: 510 VATDAGSPPLSTEETLLLRVAD 531
              D G PPLS   TL + VAD
Sbjct: 649 AVQDHGQPPLSATVTLTVAVAD 670



 Score =  116 bits (290), Expect = 8e-26
 Identities = 146/540 (27%), Positives = 214/540 (39%), Gaps = 88/540 (16%)

Query: 131 LDRERRD-HYSFVAAT-----LLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE    H+  + A+     L    V V + V D ND++P F L   ++ V E  P GT
Sbjct: 204 LDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGT 263

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
                 A D D G      Y+  +   LP D     FQL   T                 
Sbjct: 264 QLLTVTATDRDEGANGEVTYSFRK---LP-DTQLLKFQLNKYTG---------------- 303

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
             ++ +   LD EE   + ++I+A DGG    T    V + V D NDN P        + 
Sbjct: 304 --EIKISENLDYEETGFYEIEIQAEDGGAYLATA--KVLITVEDVNDNSPELTITSLFSP 359

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           V ED+  G  V  +   D D   NG V  S+ A            L      +++    +
Sbjct: 360 VTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAY-----------LPFKLEKSIDSYYRL 408

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLTEGGV 423
           V + R LDRE  + + + V A DGG+ P        + V D+NDN P    V + T    
Sbjct: 409 V-IHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTY--- 464

Query: 424 ARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPG 483
             + E    G  +  V+  D D       +   ++   L + +I    +G      +   
Sbjct: 465 --IPENNARGASIFSVTALDPDS------KENAQIIYSLAEDTI----QGVPLSSYISIN 512

Query: 484 GPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP--LFSQ 541
              GV +       D E     ++ + A+D+G PPLS+  +L L V D ND  P  L+  
Sbjct: 513 SDTGVLYALRS--FDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPA 570

Query: 542 QHYKASVS-----EAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
                S        +A PG +V  V A D D     +AWL Y +++ S P          
Sbjct: 571 LPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG--QNAWLSYRLLKASEP---------- 618

Query: 597 VHTAECGPSFAIDSESGAISTIRTL-DREVQEAVELKVVAQDLGEPPLSATCLVSITVDD 655
                    FA+   +G + T R L DR+  +   L V  QD G+PPLSAT  +++ V D
Sbjct: 619 -------GLFAVGEHTGEVRTARALLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 670



 Score =  105 bits (263), Expect = 1e-22
 Identities = 122/438 (27%), Positives = 177/438 (40%), Gaps = 67/438 (15%)

Query: 248 LVLLRRLDREEAAAHRLQ-IEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306
           L+   R+DREE  A   + + +++     R  L  +E+ V D NDN P F+ +     + 
Sbjct: 88  LITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKIN 147

Query: 307 EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
           E+   G       A D D+G N    Y +   +         A G      V E S    
Sbjct: 148 ENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHS---- 203

Query: 367 VWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARV 426
               LDRE +A H LV+ A DGG      TV VS+ V D NDN P   V  L E  V+ V
Sbjct: 204 ----LDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAP---VFTLPEYRVS-V 255

Query: 427 SEGARPGDYVARVSVSDADGDWEKEDEATGELGVG---LGDGSI---SLSLEGGEGDFAL 480
            E    G  +  V+ +D D      + A GE+      L D  +    L+   GE     
Sbjct: 256 PENLPVGTQLLTVTATDRD------EGANGEVTYSFRKLPDTQLLKFQLNKYTGE----- 304

Query: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540
                     + +   LD E    YE+ + A D G+  L+T + +L+ V D+ND  P  +
Sbjct: 305 ----------IKISENLDYEETGFYEIEIQAEDGGAY-LATAK-VLITVEDVNDNSPELT 352

Query: 541 QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAW---LRYTVVQLSAPCNLGSLQSKMV 597
                + V+E +  GTVV  ++  D D   +       L Y   +L    ++ S    ++
Sbjct: 353 ITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEK--SIDSYYRLVI 410

Query: 598 HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
           H                    R LDRE   +  + V A D G PPLS      + V D+N
Sbjct: 411 H--------------------RALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADIN 450

Query: 658 DNEPIFWRQVYNATIAEH 675
           DN P F +  Y   I E+
Sbjct: 451 DNPPTFSQVSYFTYIPEN 468



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 79/292 (27%), Positives = 119/292 (40%), Gaps = 42/292 (14%)

Query: 391 EPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEK 450
           E  V    + I V D+NDN P     F  E    +++E    G         D D     
Sbjct: 115 EDRVKLFGIEIEVTDINDNAPK----FQAENLDVKINENVAAGMRFPLPEAIDPD----- 165

Query: 451 EDEATGELGVGLGDGSISLSLEGGEGDFAL-LPGGPPGVFF--LCVEGPLDRESRDLYEL 507
                      +G  S+          F+L +     GV +  L +E  LDRE   ++ L
Sbjct: 166 -----------VGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHHL 214

Query: 508 LLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDAD 567
           +L A+D G P  S    + + V D ND  P+F+   Y+ SV E    GT ++ V+A+D D
Sbjct: 215 VLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRD 274

Query: 568 EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQE 627
           E  +    + Y+  +L     L                F ++  +G I     LD E   
Sbjct: 275 EGANGE--VTYSFRKLPDTQLL---------------KFQLNKYTGEIKISENLDYEETG 317

Query: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVG 679
             E+++ A+D G     AT  V ITV+DVNDN P        + + E +P+G
Sbjct: 318 FYEIEIQAEDGGA--YLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLG 367


>gi|14196448 protocadherin gamma subfamily A, 10 isoform 2 precursor
           [Homo sapiens]
          Length = 850

 Score =  246 bits (629), Expect = 4e-65
 Identities = 189/604 (31%), Positives = 287/604 (47%), Gaps = 85/604 (14%)

Query: 69  LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTA 128
           ++ S+ E L   + VG+I   L  A ++             + L   F ++P +G + TA
Sbjct: 35  ISYSIPEELEKGSFVGNISKDLGLAPRELAERGVRIVSRGRTQL---FSLNPRSGSLITA 91

Query: 129 RRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSP 181
            R+DRE     S         +V+       +EI V D+ND++P+F  ++L + ++E   
Sbjct: 92  GRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVA 151

Query: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
            G  F LP A DPD G+ S Q Y L              F LR ++            ++
Sbjct: 152 AGMRFPLPEAIDPDVGVNSLQSYQL---------SPNKHFSLRVQS-----------RAN 191

Query: 242 PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
            ++  +LVL   LDREE A H L + A DGG P R+G + V + V D NDN PVF   EY
Sbjct: 192 GVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEY 251

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
           R +V E+   G ++  V ATDRD G NG V YS   R++P              F + + 
Sbjct: 252 RVSVPENLPVGTQLLTVTATDRDEGANGEVTYSF--RKLPDT--------QLLKFQLNKY 301

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +G +++   LD E   ++++ ++A DGGA   +AT +V I V DVNDN P + +  L   
Sbjct: 302 TGEIKISENLDYEETGFYEIEIQAEDGGA--YLATAKVLITVEDVNDNSPELTITSL--- 356

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
             + V+E +  G  VA ++V D D +                +G ++ S+       A L
Sbjct: 357 -FSPVTEDSPLGTVVALLNVHDLDSE---------------QNGQVTCSI------LAYL 394

Query: 482 P----GGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
           P          + L +   LDRE    Y + + ATD GSPPLSTE   +L+VAD+ND PP
Sbjct: 395 PFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPP 454

Query: 538 LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
            FSQ  Y   + E  A G  +  V+A D D    ++A + Y            SL    +
Sbjct: 455 TFSQVSYFTYIPENNARGASIFSVTALDPD--SKENAQIIY------------SLAEDTI 500

Query: 598 HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
                    +I+S++G +  +R+ D E    ++++V A D G+PPLS+   +S+ V D N
Sbjct: 501 QGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQN 560

Query: 658 DNEP 661
           DN P
Sbjct: 561 DNAP 564



 Score =  127 bits (318), Expect = 5e-29
 Identities = 145/502 (28%), Positives = 205/502 (40%), Gaps = 81/502 (16%)

Query: 50  LLVHVWLWAASGSSAQLFNLT---LSVDEGLPPDTLVGDIRAGLPAAQQQEGSG---FFL 103
           +LV V ++ A+  +A +F L    +SV E LP    VG     + A  + EG+     + 
Sbjct: 230 VLVSVTVFDAN-DNAPVFTLPEYRVSVPENLP----VGTQLLTVTATDRDEGANGEVTYS 284

Query: 104 SEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLG----AVVQVEIRVND 159
                D+ LL  F ++  TG I+ +  LD E    Y        G    A  +V I V D
Sbjct: 285 FRKLPDTQLLK-FQLNKYTGEIKISENLDYEETGFYEIEIQAEDGGAYLATAKVLITVED 343

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           VND+SP   + SL   V+E SP GT   L   HD D+                  +  G 
Sbjct: 344 VNDNSPELTITSLFSPVTEDSPLGTVVALLNVHDLDS------------------EQNG- 384

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL 279
             Q+       LP  L     S      LV+ R LDRE+ +++ + + A DGG P  +  
Sbjct: 385 --QVTCSILAYLPFKLEKSIDSYYR---LVIHRALDREQVSSYNITVTATDGGSPPLSTE 439

Query: 280 LSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQ 339
               L+V D NDNPP F Q  Y   + E+   GA +  V A D D   N  + YS+    
Sbjct: 440 AHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQIIYSLAEDT 499

Query: 340 VPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRV 399
           + G          ++Y ++   +GV+   R  D E     Q+ V A D G  P  + V +
Sbjct: 500 IQGVPL-------SSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSL 552

Query: 400 SIAVLDVNDNRPAI-HVLFLTEG--GVARVSEGARPGDYVARVSVSDADGDWEKEDEATG 456
           S+ VLD NDN P I +    T+G  GV      A PG  V +V   D D           
Sbjct: 553 SLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRD----------- 601

Query: 457 ELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYE-------LLL 509
                        S +     + LL    PG+F +       R +R L +       L++
Sbjct: 602 -------------SGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVV 648

Query: 510 VATDAGSPPLSTEETLLLRVAD 531
              D G PPLS   TL + VAD
Sbjct: 649 AVQDHGQPPLSATVTLTVAVAD 670



 Score =  116 bits (290), Expect = 8e-26
 Identities = 146/540 (27%), Positives = 214/540 (39%), Gaps = 88/540 (16%)

Query: 131 LDRERRD-HYSFVAAT-----LLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE    H+  + A+     L    V V + V D ND++P F L   ++ V E  P GT
Sbjct: 204 LDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGT 263

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
                 A D D G      Y+  +   LP D     FQL   T                 
Sbjct: 264 QLLTVTATDRDEGANGEVTYSFRK---LP-DTQLLKFQLNKYTG---------------- 303

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
             ++ +   LD EE   + ++I+A DGG    T    V + V D NDN P        + 
Sbjct: 304 --EIKISENLDYEETGFYEIEIQAEDGGAYLATA--KVLITVEDVNDNSPELTITSLFSP 359

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           V ED+  G  V  +   D D   NG V  S+ A            L      +++    +
Sbjct: 360 VTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAY-----------LPFKLEKSIDSYYRL 408

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLTEGGV 423
           V + R LDRE  + + + V A DGG+ P        + V D+NDN P    V + T    
Sbjct: 409 V-IHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTY--- 464

Query: 424 ARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPG 483
             + E    G  +  V+  D D       +   ++   L + +I    +G      +   
Sbjct: 465 --IPENNARGASIFSVTALDPDS------KENAQIIYSLAEDTI----QGVPLSSYISIN 512

Query: 484 GPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP--LFSQ 541
              GV +       D E     ++ + A+D+G PPLS+  +L L V D ND  P  L+  
Sbjct: 513 SDTGVLYALRS--FDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPA 570

Query: 542 QHYKASVS-----EAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
                S        +A PG +V  V A D D     +AWL Y +++ S P          
Sbjct: 571 LPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG--QNAWLSYRLLKASEP---------- 618

Query: 597 VHTAECGPSFAIDSESGAISTIRTL-DREVQEAVELKVVAQDLGEPPLSATCLVSITVDD 655
                    FA+   +G + T R L DR+  +   L V  QD G+PPLSAT  +++ V D
Sbjct: 619 -------GLFAVGEHTGEVRTARALLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 670



 Score =  105 bits (263), Expect = 1e-22
 Identities = 122/438 (27%), Positives = 177/438 (40%), Gaps = 67/438 (15%)

Query: 248 LVLLRRLDREEAAAHRLQ-IEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306
           L+   R+DREE  A   + + +++     R  L  +E+ V D NDN P F+ +     + 
Sbjct: 88  LITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKIN 147

Query: 307 EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
           E+   G       A D D+G N    Y +   +         A G      V E S    
Sbjct: 148 ENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHS---- 203

Query: 367 VWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARV 426
               LDRE +A H LV+ A DGG      TV VS+ V D NDN P   V  L E  V+ V
Sbjct: 204 ----LDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAP---VFTLPEYRVS-V 255

Query: 427 SEGARPGDYVARVSVSDADGDWEKEDEATGELGVG---LGDGSI---SLSLEGGEGDFAL 480
            E    G  +  V+ +D D      + A GE+      L D  +    L+   GE     
Sbjct: 256 PENLPVGTQLLTVTATDRD------EGANGEVTYSFRKLPDTQLLKFQLNKYTGE----- 304

Query: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540
                     + +   LD E    YE+ + A D G+  L+T + +L+ V D+ND  P  +
Sbjct: 305 ----------IKISENLDYEETGFYEIEIQAEDGGAY-LATAK-VLITVEDVNDNSPELT 352

Query: 541 QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAW---LRYTVVQLSAPCNLGSLQSKMV 597
                + V+E +  GTVV  ++  D D   +       L Y   +L    ++ S    ++
Sbjct: 353 ITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEK--SIDSYYRLVI 410

Query: 598 HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
           H                    R LDRE   +  + V A D G PPLS      + V D+N
Sbjct: 411 H--------------------RALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADIN 450

Query: 658 DNEPIFWRQVYNATIAEH 675
           DN P F +  Y   I E+
Sbjct: 451 DNPPTFSQVSYFTYIPEN 468



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 79/292 (27%), Positives = 119/292 (40%), Gaps = 42/292 (14%)

Query: 391 EPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEK 450
           E  V    + I V D+NDN P     F  E    +++E    G         D D     
Sbjct: 115 EDRVKLFGIEIEVTDINDNAPK----FQAENLDVKINENVAAGMRFPLPEAIDPD----- 165

Query: 451 EDEATGELGVGLGDGSISLSLEGGEGDFAL-LPGGPPGVFF--LCVEGPLDRESRDLYEL 507
                      +G  S+          F+L +     GV +  L +E  LDRE   ++ L
Sbjct: 166 -----------VGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHHL 214

Query: 508 LLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDAD 567
           +L A+D G P  S    + + V D ND  P+F+   Y+ SV E    GT ++ V+A+D D
Sbjct: 215 VLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRD 274

Query: 568 EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQE 627
           E  +    + Y+  +L     L                F ++  +G I     LD E   
Sbjct: 275 EGANGE--VTYSFRKLPDTQLL---------------KFQLNKYTGEIKISENLDYEETG 317

Query: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVG 679
             E+++ A+D G     AT  V ITV+DVNDN P        + + E +P+G
Sbjct: 318 FYEIEIQAEDGGA--YLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLG 367


>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
          Length = 1040

 Score =  245 bits (625), Expect = 1e-64
 Identities = 205/642 (31%), Positives = 301/642 (46%), Gaps = 97/642 (15%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
           ++ LL+   LW   G  +QL     +V E     T VG+I   L     +  +  F +  
Sbjct: 1   MIVLLLFALLWMVEGVFSQLH---YTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVP 57

Query: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVV-------QVEIRVND 159
           +  +P LD   ++ +TG++    ++DRE+    S      L   +       QVEI V D
Sbjct: 58  NSRTPYLD---LNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLD 114

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           +ND+ P FP   L +++SE + PGT F L  A DPD G  S + Y +   S         
Sbjct: 115 INDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNS--------- 165

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGG------- 272
           +F L  +T G        G+       +LVL + LDRE+ A HR  + A DGG       
Sbjct: 166 YFSLDVQTQGD-------GNRFA----ELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGE 214

Query: 273 ------------RPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRA 320
                       + +RTG   + +RVLD NDN P F+Q  Y  ++ E++ PG  V ++ A
Sbjct: 215 GGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNA 274

Query: 321 TDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQ 380
           TD D G NG V YS  +   P A            F +   +G + V   LD E    +Q
Sbjct: 275 TDPDEGQNGEVVYSFSSHISPRARE---------LFGLSPRTGRLEVSGELDYEESPVYQ 325

Query: 381 LVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVS 440
           + V+A+D G     A  +V + VLD NDN P I    + E     VSEGA PG  VA  S
Sbjct: 326 VYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEA----VSEGAAPGTVVALFS 381

Query: 441 VSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRE 500
           V+D D   E+  +   EL   LGD  +   L+    ++          + +  E PLDRE
Sbjct: 382 VTDRDS--EENGQVQCEL---LGD--VPFRLKSSFKNY----------YTIVTEAPLDRE 424

Query: 501 SRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMW 560
           + D Y L +VA D G P LST +++ ++V+D+ND  P FSQ  Y   V+E   PG  +  
Sbjct: 425 AGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYA 484

Query: 561 VSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT 620
           VSA+D DE    +A L Y++++         +Q   V T       +I+SE+G +  +R+
Sbjct: 485 VSATDRDEGA--NAQLAYSILEC-------QIQGMSVFT-----YVSINSENGYLYALRS 530

Query: 621 LDREVQEAVELKVVAQDLGEP-PLSATCLVSITVDDVNDNEP 661
            D E  +    +V A+D G P  L+    V+I + D NDN P
Sbjct: 531 FDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAP 572



 Score =  143 bits (361), Expect = 5e-34
 Identities = 150/525 (28%), Positives = 214/525 (40%), Gaps = 85/525 (16%)

Query: 197 GLFSTQGYTLVQPSD-------LPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLV 249
           G+FS   YT+ +  +       + +D      +L  R    +P+   P     LE   L 
Sbjct: 15  GVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLY 74

Query: 250 LLRRLDREEAAAHR----LQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAV 305
           +  ++DRE+         L +E +         L  VE+ VLD NDNPP F + +    +
Sbjct: 75  VNEKIDREQICKQSPSCVLHLEVF---LENPLELFQVEIEVLDINDNPPSFPEPDLTVEI 131

Query: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVV 365
            E A PG       A D D+G N    Y +               GD   FA   L    
Sbjct: 132 SESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQ--TQGDGNRFAELVLE--- 186

Query: 366 RVWRPLDREAQAWHQLVVEARDGGA-------------------EPEVATVRVSIAVLDV 406
              +PLDRE QA H+ V+ A DGG                    +    T  ++I VLD 
Sbjct: 187 ---KPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRVLDS 243

Query: 407 NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS 466
           NDN PA      T      + E + PG  V +++ +D D          G+ G  +   S
Sbjct: 244 NDNVPAFDQPVYT----VSLPENSPPGTLVIQLNATDPD---------EGQNGEVVYSFS 290

Query: 467 ISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLL 526
             +S    E     L G  P    L V G LD E   +Y++ + A D G   +     +L
Sbjct: 291 SHISPRARE-----LFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVL 345

Query: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
           +RV D ND  P  S    K +VSE AAPGTVV   S +D D   +               
Sbjct: 346 VRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEEN--------------- 390

Query: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQEAVELKVVAQDLGEPPL 643
              G +Q +++        F + S      TI T   LDRE  ++  L VVA+D GEP L
Sbjct: 391 ---GQVQCELLGDVP----FRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443

Query: 644 SATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISA 688
           S +  + + V DVNDN P F + VY+  + E+   G  ++  +SA
Sbjct: 444 STSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPG-AYIYAVSA 487



 Score =  121 bits (303), Expect = 3e-27
 Identities = 142/518 (27%), Positives = 210/518 (40%), Gaps = 92/518 (17%)

Query: 155 IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214
           IRV D ND+ P F      + + E SPPGT      A DPD G     G  +   S    
Sbjct: 238 IRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEG---QNGEVVYSFSSHIS 294

Query: 215 DPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP 274
             A   F L  RT                    L +   LD EE+  +++ ++A D G  
Sbjct: 295 PRARELFGLSPRTGR------------------LEVSGELDYEESPVYQVYVQAKDLGPN 336

Query: 275 RRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYS 334
                  V +RVLD NDN P       + AV E A PG  V     TDRD   NG V+  
Sbjct: 337 AVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCE 396

Query: 335 VRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWR--PLDREAQAWHQLVVEARDGGAEP 392
           +              LGD  +           +    PLDREA   + L V ARD G EP
Sbjct: 397 L--------------LGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG-EP 441

Query: 393 EVATVR-VSIAVLDVNDNRPA----IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGD 447
            ++T + + + V DVNDN P     ++ +++TE  V        PG Y+  VS +D D  
Sbjct: 442 ALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNV--------PGAYIYAVSATDRD-- 491

Query: 448 WEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYEL 507
               + A  +L   + +  I      G   F  +       +   +    D E    +  
Sbjct: 492 ----EGANAQLAYSILECQIQ-----GMSVFTYVSINSENGYLYALRS-FDYEQLKDFSF 541

Query: 508 LLVATDAGSPP-LSTEETLLLRVADLNDQPPLF-------SQQHYKASVSEAAAPGTVVM 559
            + A DAGSP  L+   T+ + + D ND  P         +    +  +  +A PG ++ 
Sbjct: 542 QVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLT 601

Query: 560 WVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIR 619
            V+A DAD+   ++A L Y++V+     NL                F +D  +G + T R
Sbjct: 602 RVAAVDADDG--ENARLTYSIVR-GNEMNL----------------FRMDWRTGELRTAR 642

Query: 620 TLD--REVQEAVELKVVAQDLGEPPLSATCLVSITVDD 655
            +   R+ Q   EL +  +D G+PPLS+T  + + + D
Sbjct: 643 RVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680


>gi|14589914 protocadherin 10 isoform 2 precursor [Homo sapiens]
          Length = 896

 Score =  245 bits (625), Expect = 1e-64
 Identities = 205/642 (31%), Positives = 301/642 (46%), Gaps = 97/642 (15%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSED 106
           ++ LL+   LW   G  +QL     +V E     T VG+I   L     +  +  F +  
Sbjct: 1   MIVLLLFALLWMVEGVFSQLH---YTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVP 57

Query: 107 SDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVV-------QVEIRVND 159
           +  +P LD   ++ +TG++    ++DRE+    S      L   +       QVEI V D
Sbjct: 58  NSRTPYLD---LNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLD 114

Query: 160 VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP 219
           +ND+ P FP   L +++SE + PGT F L  A DPD G  S + Y +   S         
Sbjct: 115 INDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNS--------- 165

Query: 220 FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGG------- 272
           +F L  +T G        G+       +LVL + LDRE+ A HR  + A DGG       
Sbjct: 166 YFSLDVQTQGD-------GNRFA----ELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGE 214

Query: 273 ------------RPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRA 320
                       + +RTG   + +RVLD NDN P F+Q  Y  ++ E++ PG  V ++ A
Sbjct: 215 GGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNA 274

Query: 321 TDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQ 380
           TD D G NG V YS  +   P A            F +   +G + V   LD E    +Q
Sbjct: 275 TDPDEGQNGEVVYSFSSHISPRARE---------LFGLSPRTGRLEVSGELDYEESPVYQ 325

Query: 381 LVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVS 440
           + V+A+D G     A  +V + VLD NDN P I    + E     VSEGA PG  VA  S
Sbjct: 326 VYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEA----VSEGAAPGTVVALFS 381

Query: 441 VSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRE 500
           V+D D   E+  +   EL   LGD  +   L+    ++          + +  E PLDRE
Sbjct: 382 VTDRDS--EENGQVQCEL---LGD--VPFRLKSSFKNY----------YTIVTEAPLDRE 424

Query: 501 SRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMW 560
           + D Y L +VA D G P LST +++ ++V+D+ND  P FSQ  Y   V+E   PG  +  
Sbjct: 425 AGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYA 484

Query: 561 VSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT 620
           VSA+D DE    +A L Y++++         +Q   V T       +I+SE+G +  +R+
Sbjct: 485 VSATDRDEGA--NAQLAYSILEC-------QIQGMSVFT-----YVSINSENGYLYALRS 530

Query: 621 LDREVQEAVELKVVAQDLGEP-PLSATCLVSITVDDVNDNEP 661
            D E  +    +V A+D G P  L+    V+I + D NDN P
Sbjct: 531 FDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAP 572



 Score =  143 bits (361), Expect = 5e-34
 Identities = 150/525 (28%), Positives = 214/525 (40%), Gaps = 85/525 (16%)

Query: 197 GLFSTQGYTLVQPSD-------LPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLV 249
           G+FS   YT+ +  +       + +D      +L  R    +P+   P     LE   L 
Sbjct: 15  GVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLY 74

Query: 250 LLRRLDREEAAAHR----LQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAV 305
           +  ++DRE+         L +E +         L  VE+ VLD NDNPP F + +    +
Sbjct: 75  VNEKIDREQICKQSPSCVLHLEVF---LENPLELFQVEIEVLDINDNPPSFPEPDLTVEI 131

Query: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVV 365
            E A PG       A D D+G N    Y +               GD   FA   L    
Sbjct: 132 SESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQ--TQGDGNRFAELVLE--- 186

Query: 366 RVWRPLDREAQAWHQLVVEARDGGA-------------------EPEVATVRVSIAVLDV 406
              +PLDRE QA H+ V+ A DGG                    +    T  ++I VLD 
Sbjct: 187 ---KPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRVLDS 243

Query: 407 NDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS 466
           NDN PA      T      + E + PG  V +++ +D D          G+ G  +   S
Sbjct: 244 NDNVPAFDQPVYT----VSLPENSPPGTLVIQLNATDPD---------EGQNGEVVYSFS 290

Query: 467 ISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLL 526
             +S    E     L G  P    L V G LD E   +Y++ + A D G   +     +L
Sbjct: 291 SHISPRARE-----LFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVL 345

Query: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
           +RV D ND  P  S    K +VSE AAPGTVV   S +D D   +               
Sbjct: 346 VRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEEN--------------- 390

Query: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQEAVELKVVAQDLGEPPL 643
              G +Q +++        F + S      TI T   LDRE  ++  L VVA+D GEP L
Sbjct: 391 ---GQVQCELLGDVP----FRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443

Query: 644 SATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISA 688
           S +  + + V DVNDN P F + VY+  + E+   G  ++  +SA
Sbjct: 444 STSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPG-AYIYAVSA 487



 Score =  121 bits (303), Expect = 3e-27
 Identities = 142/518 (27%), Positives = 210/518 (40%), Gaps = 92/518 (17%)

Query: 155 IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214
           IRV D ND+ P F      + + E SPPGT      A DPD G     G  +   S    
Sbjct: 238 IRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEG---QNGEVVYSFSSHIS 294

Query: 215 DPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP 274
             A   F L  RT                    L +   LD EE+  +++ ++A D G  
Sbjct: 295 PRARELFGLSPRTGR------------------LEVSGELDYEESPVYQVYVQAKDLGPN 336

Query: 275 RRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYS 334
                  V +RVLD NDN P       + AV E A PG  V     TDRD   NG V+  
Sbjct: 337 AVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCE 396

Query: 335 VRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWR--PLDREAQAWHQLVVEARDGGAEP 392
           +              LGD  +           +    PLDREA   + L V ARD G EP
Sbjct: 397 L--------------LGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG-EP 441

Query: 393 EVATVR-VSIAVLDVNDNRPA----IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGD 447
            ++T + + + V DVNDN P     ++ +++TE  V        PG Y+  VS +D D  
Sbjct: 442 ALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNV--------PGAYIYAVSATDRD-- 491

Query: 448 WEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYEL 507
               + A  +L   + +  I      G   F  +       +   +    D E    +  
Sbjct: 492 ----EGANAQLAYSILECQIQ-----GMSVFTYVSINSENGYLYALRS-FDYEQLKDFSF 541

Query: 508 LLVATDAGSPP-LSTEETLLLRVADLNDQPPLF-------SQQHYKASVSEAAAPGTVVM 559
            + A DAGSP  L+   T+ + + D ND  P         +    +  +  +A PG ++ 
Sbjct: 542 QVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLT 601

Query: 560 WVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIR 619
            V+A DAD+   ++A L Y++V+     NL                F +D  +G + T R
Sbjct: 602 RVAAVDADDG--ENARLTYSIVR-GNEMNL----------------FRMDWRTGELRTAR 642

Query: 620 TLD--REVQEAVELKVVAQDLGEPPLSATCLVSITVDD 655
            +   R+ Q   EL +  +D G+PPLS+T  + + + D
Sbjct: 643 RVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680


>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
          Length = 1101

 Score =  241 bits (616), Expect = 1e-63
 Identities = 194/629 (30%), Positives = 306/629 (48%), Gaps = 87/629 (13%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDI-----RAGLPAAQQQEGSGF 101
           +L LL  +W  AA+     L NL  SV+E     T++ ++      AG  A   ++ S F
Sbjct: 8   VLLLLAILWTQAAA-----LINLKYSVEEEQRAGTVIANVAKDAREAGF-ALDPRQASAF 61

Query: 102 FLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRE---RRDHYSFVAATLLGAVVQV---EI 155
            +  +S  +P L D  ++P +G++ T +++DR+   R+     ++  ++ + +++   ++
Sbjct: 62  RVVSNS--APHLVD--INPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKV 117

Query: 156 RVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKD 215
            + D+ND++P FP   ++L++SE + PGT   L  A+DPD+G F  Q Y L  P++L   
Sbjct: 118 EIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELT-PNEL--- 173

Query: 216 PAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPR 275
                F L  +T G        GS       +LV+ + LDRE  + +  +I A DGG P 
Sbjct: 174 -----FGLEIKTRGD-------GSRFA----ELVVEKSLDRETQSHYSFRITALDGGDPP 217

Query: 276 RTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV 335
           R G + + ++V D NDN PVF +  Y  +V E++ P   V R+ A+D D G NG V YS 
Sbjct: 218 RLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSF 277

Query: 336 RARQVPGAGSGGGALGDAA--YFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE 393
                       G + D     F ++  SG+V V   LD E    ++L V+A+D G    
Sbjct: 278 Y-----------GYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSI 326

Query: 394 VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453
            A  +V+++VLD NDN P I++L +    +  VSE A PG  +A V VSD D        
Sbjct: 327 PAHCKVTVSVLDTNDNPPVINLLSVNSE-LVEVSESAPPGYVIALVRVSDRDSG------ 379

Query: 454 ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
             G +   L  G++   L+  E    +L           V+G LDRE  D Y L + A D
Sbjct: 380 LNGRVQCRLL-GNVPFRLQEYESFSTIL-----------VDGRLDREQHDQYNLTIQARD 427

Query: 514 AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDH 573
            G P L + ++  + + D ND  P FS+ +Y+  V E   PG  ++ VSA D D   +  
Sbjct: 428 GGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGS 487

Query: 574 AWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKV 633
             + Y +V               V         +I+  SG I  +R+ + E  +A E KV
Sbjct: 488 --VSYQIVP------------SQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKV 533

Query: 634 VAQDLGEPPLSATCLVSITVDDVNDNEPI 662
           +A+D G P L +   V + + DVNDN P+
Sbjct: 534 LAKDGGLPSLQSNATVRVIILDVNDNTPV 562



 Score =  132 bits (333), Expect = 8e-31
 Identities = 148/549 (26%), Positives = 214/549 (38%), Gaps = 94/549 (17%)

Query: 129 RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           + LDRE + HYSF    L G        V + I+V D ND++P F   +  + V E SPP
Sbjct: 194 KSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPP 253

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
            T      A DPD G   T G  +        D     FQ+                  P
Sbjct: 254 NTPVIRLNASDPDEG---TNGQVVYSFYGYVNDRTRELFQI-----------------DP 293

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQ---D 299
              L + +   LD EE   + L ++A D G         V + VLD NDNPPV      +
Sbjct: 294 HSGL-VTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVN 352

Query: 300 EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVE 359
                V E A PG  +  VR +DRD G NG V+  +              LG+  +   E
Sbjct: 353 SELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRL--------------LGNVPFRLQE 398

Query: 360 -ELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFL 418
            E    + V   LDRE    + L ++ARDGG     +    ++ + D NDN P     + 
Sbjct: 399 YESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYY 458

Query: 419 TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGD- 477
                  V E   PG Y+  VS  D D              +GL +GS+S  +   +   
Sbjct: 459 Q----VIVQENNTPGAYLLSVSARDPD--------------LGL-NGSVSYQIVPSQVRD 499

Query: 478 ---FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLND 534
              F  +   P       +    + E    +E  ++A D G P L +  T+ + + D+ND
Sbjct: 500 MPVFTYVSINPNSGDIYALRS-FNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVND 558

Query: 535 QPPLFSQQHYKASVSEAAAP-----GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL 589
             P+ +        +E   P     G +V  V A D DE   ++  + Y + +       
Sbjct: 559 NTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEG--ENGRVTYDMTE------- 609

Query: 590 GSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLV 649
                      + G  F ID  +G + T RT     + + EL VVA D G+  LSA+ LV
Sbjct: 610 ----------GDRG-FFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658

Query: 650 SITVDDVND 658
            I +    D
Sbjct: 659 LIYLSPALD 667



 Score =  117 bits (293), Expect = 4e-26
 Identities = 118/415 (28%), Positives = 169/415 (40%), Gaps = 58/415 (13%)

Query: 282 VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVP 341
           +++ + D NDN P F   +    + E A PG  +    A D D G  G   Y +   ++ 
Sbjct: 115 IKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELF 174

Query: 342 GAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSI 401
           G        GD + FA       + V + LDRE Q+ +   + A DGG  P + TV +SI
Sbjct: 175 GLEIK--TRGDGSRFAE------LVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSI 226

Query: 402 AVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVG 461
            V D NDN P    +F        V E + P   V R++ SD D       E T      
Sbjct: 227 KVTDSNDNNP----VFSESTYAVSVPENSPPNTPVIRLNASDPD-------EGT------ 269

Query: 462 LGDGSISLSLEGGEGDFAL-LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLS 520
             +G +  S  G   D    L    P    + V G LD E   +YEL + A D G   + 
Sbjct: 270 --NGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIP 327

Query: 521 TEETLLLRVADLNDQPP---LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLR 577
               + + V D ND PP   L S       VSE+A PG V+  V  SD D   +     R
Sbjct: 328 AHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCR 387

Query: 578 YTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQEAVELKVV 634
                      LG++  ++              E  + STI     LDRE  +   L + 
Sbjct: 388 L----------LGNVPFRL-------------QEYESFSTILVDGRLDREQHDQYNLTIQ 424

Query: 635 AQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISAQ 689
           A+D G P L +    ++ + D NDN P F +  Y   + E+   G  +L  +SA+
Sbjct: 425 ARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPG-AYLLSVSAR 478



 Score =  115 bits (287), Expect = 2e-25
 Identities = 130/475 (27%), Positives = 191/475 (40%), Gaps = 63/475 (13%)

Query: 71  LSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARR 130
           +SV E  PP+T V  + A  P  +   G   +      +    + F + P +G++     
Sbjct: 245 VSVPENSPPNTPVIRLNASDPD-EGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGA 303

Query: 131 LDRERRDHYSF-VAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQ---LDVSELSP 181
           LD E    Y   V A  LG     A  +V + V D ND+ P   L S+    ++VSE +P
Sbjct: 304 LDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAP 363

Query: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
           PG    L    D D+GL                       +++ R  G +P  L      
Sbjct: 364 PGYVIALVRVSDRDSGLNG---------------------RVQCRLLGNVPFRL-----Q 397

Query: 242 PLEPLDLVLLR-RLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE 300
             E    +L+  RLDRE+   + L I+A DGG P      S  + + DENDN P F +  
Sbjct: 398 EYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPY 457

Query: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
           Y+  V+E+  PGA +  V A D DLG NG V Y +   QV         +    Y ++  
Sbjct: 458 YQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRD-------MPVFTYVSINP 510

Query: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
            SG +   R  + E     +  V A+DGG     +   V + +LDVNDN P I    L  
Sbjct: 511 NSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLIN 570

Query: 421 G-GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFA 479
           G     +   +  G  V  V   D D          GE      +G ++  +  G+  F 
Sbjct: 571 GTAEVYIPRNSGIGYLVTVVKAEDYD---------EGE------NGRVTYDMTEGDRGFF 615

Query: 480 LLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLND 534
            +      V      G     S+  YEL++VA D G   LS    +L+ ++   D
Sbjct: 616 EIDQVNGEVRTTRTFG---ESSKSSYELIVVAHDHGKTSLSASALVLIYLSPALD 667



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 91/330 (27%), Positives = 141/330 (42%), Gaps = 52/330 (15%)

Query: 362 SGVVRVWRPLDRE--AQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLT 419
           SG++   + +DR+   +   + ++      +  E+  ++V I   D+NDN P+     + 
Sbjct: 78  SGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK--DLNDNAPSFPAAQIE 135

Query: 420 EGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS------ISLSLEG 473
                 +SE A PG  +   S  D D         +G  GV   + +      + +   G
Sbjct: 136 ----LEISEAASPGTRIPLDSAYDPD---------SGSFGVQTYELTPNELFGLEIKTRG 182

Query: 474 GEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLN 533
               FA L           VE  LDRE++  Y   + A D G PP      L ++V D N
Sbjct: 183 DGSRFAEL----------VVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSN 232

Query: 534 DQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQ 593
           D  P+FS+  Y  SV E + P T V+ ++ASD DE  +      +           G + 
Sbjct: 233 DNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSF----------YGYVN 282

Query: 594 SKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITV 653
            +   T E    F ID  SG ++    LD E     EL V A+DLG   + A C V+++V
Sbjct: 283 DR---TREL---FQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSV 336

Query: 654 DDVNDNEPIFWRQVYNA---TIAEHAPVGH 680
            D NDN P+      N+    ++E AP G+
Sbjct: 337 LDTNDNPPVINLLSVNSELVEVSESAPPGY 366


>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
          Length = 1100

 Score =  241 bits (616), Expect = 1e-63
 Identities = 194/629 (30%), Positives = 306/629 (48%), Gaps = 87/629 (13%)

Query: 47  LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDI-----RAGLPAAQQQEGSGF 101
           +L LL  +W  AA+     L NL  SV+E     T++ ++      AG  A   ++ S F
Sbjct: 8   VLLLLAILWTQAAA-----LINLKYSVEEEQRAGTVIANVAKDAREAGF-ALDPRQASAF 61

Query: 102 FLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRE---RRDHYSFVAATLLGAVVQV---EI 155
            +  +S  +P L D  ++P +G++ T +++DR+   R+     ++  ++ + +++   ++
Sbjct: 62  RVVSNS--APHLVD--INPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKV 117

Query: 156 RVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKD 215
            + D+ND++P FP   ++L++SE + PGT   L  A+DPD+G F  Q Y L  P++L   
Sbjct: 118 EIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELT-PNEL--- 173

Query: 216 PAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPR 275
                F L  +T G        GS       +LV+ + LDRE  + +  +I A DGG P 
Sbjct: 174 -----FGLEIKTRGD-------GSRFA----ELVVEKSLDRETQSHYSFRITALDGGDPP 217

Query: 276 RTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV 335
           R G + + ++V D NDN PVF +  Y  +V E++ P   V R+ A+D D G NG V YS 
Sbjct: 218 RLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSF 277

Query: 336 RARQVPGAGSGGGALGDAA--YFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE 393
                       G + D     F ++  SG+V V   LD E    ++L V+A+D G    
Sbjct: 278 Y-----------GYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSI 326

Query: 394 VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453
            A  +V+++VLD NDN P I++L +    +  VSE A PG  +A V VSD D        
Sbjct: 327 PAHCKVTVSVLDTNDNPPVINLLSVNSE-LVEVSESAPPGYVIALVRVSDRDSG------ 379

Query: 454 ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
             G +   L  G++   L+  E    +L           V+G LDRE  D Y L + A D
Sbjct: 380 LNGRVQCRLL-GNVPFRLQEYESFSTIL-----------VDGRLDREQHDQYNLTIQARD 427

Query: 514 AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDH 573
            G P L + ++  + + D ND  P FS+ +Y+  V E   PG  ++ VSA D D   +  
Sbjct: 428 GGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGS 487

Query: 574 AWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKV 633
             + Y +V               V         +I+  SG I  +R+ + E  +A E KV
Sbjct: 488 --VSYQIVP------------SQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKV 533

Query: 634 VAQDLGEPPLSATCLVSITVDDVNDNEPI 662
           +A+D G P L +   V + + DVNDN P+
Sbjct: 534 LAKDGGLPSLQSNATVRVIILDVNDNTPV 562



 Score =  132 bits (333), Expect = 8e-31
 Identities = 148/549 (26%), Positives = 214/549 (38%), Gaps = 94/549 (17%)

Query: 129 RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           + LDRE + HYSF    L G        V + I+V D ND++P F   +  + V E SPP
Sbjct: 194 KSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPP 253

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
            T      A DPD G   T G  +        D     FQ+                  P
Sbjct: 254 NTPVIRLNASDPDEG---TNGQVVYSFYGYVNDRTRELFQI-----------------DP 293

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQ---D 299
              L + +   LD EE   + L ++A D G         V + VLD NDNPPV      +
Sbjct: 294 HSGL-VTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVN 352

Query: 300 EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVE 359
                V E A PG  +  VR +DRD G NG V+  +              LG+  +   E
Sbjct: 353 SELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRL--------------LGNVPFRLQE 398

Query: 360 -ELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFL 418
            E    + V   LDRE    + L ++ARDGG     +    ++ + D NDN P     + 
Sbjct: 399 YESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYY 458

Query: 419 TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGD- 477
                  V E   PG Y+  VS  D D              +GL +GS+S  +   +   
Sbjct: 459 Q----VIVQENNTPGAYLLSVSARDPD--------------LGL-NGSVSYQIVPSQVRD 499

Query: 478 ---FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLND 534
              F  +   P       +    + E    +E  ++A D G P L +  T+ + + D+ND
Sbjct: 500 MPVFTYVSINPNSGDIYALRS-FNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVND 558

Query: 535 QPPLFSQQHYKASVSEAAAP-----GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL 589
             P+ +        +E   P     G +V  V A D DE   ++  + Y + +       
Sbjct: 559 NTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEG--ENGRVTYDMTE------- 609

Query: 590 GSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLV 649
                      + G  F ID  +G + T RT     + + EL VVA D G+  LSA+ LV
Sbjct: 610 ----------GDRG-FFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALV 658

Query: 650 SITVDDVND 658
            I +    D
Sbjct: 659 LIYLSPALD 667



 Score =  117 bits (293), Expect = 4e-26
 Identities = 118/415 (28%), Positives = 169/415 (40%), Gaps = 58/415 (13%)

Query: 282 VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVP 341
           +++ + D NDN P F   +    + E A PG  +    A D D G  G   Y +   ++ 
Sbjct: 115 IKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELF 174

Query: 342 GAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSI 401
           G        GD + FA       + V + LDRE Q+ +   + A DGG  P + TV +SI
Sbjct: 175 GLEIK--TRGDGSRFAE------LVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSI 226

Query: 402 AVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVG 461
            V D NDN P    +F        V E + P   V R++ SD D       E T      
Sbjct: 227 KVTDSNDNNP----VFSESTYAVSVPENSPPNTPVIRLNASDPD-------EGT------ 269

Query: 462 LGDGSISLSLEGGEGDFAL-LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLS 520
             +G +  S  G   D    L    P    + V G LD E   +YEL + A D G   + 
Sbjct: 270 --NGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIP 327

Query: 521 TEETLLLRVADLNDQPP---LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLR 577
               + + V D ND PP   L S       VSE+A PG V+  V  SD D   +     R
Sbjct: 328 AHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCR 387

Query: 578 YTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQEAVELKVV 634
                      LG++  ++              E  + STI     LDRE  +   L + 
Sbjct: 388 L----------LGNVPFRL-------------QEYESFSTILVDGRLDREQHDQYNLTIQ 424

Query: 635 AQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISAQ 689
           A+D G P L +    ++ + D NDN P F +  Y   + E+   G  +L  +SA+
Sbjct: 425 ARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPG-AYLLSVSAR 478



 Score =  115 bits (287), Expect = 2e-25
 Identities = 130/475 (27%), Positives = 191/475 (40%), Gaps = 63/475 (13%)

Query: 71  LSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARR 130
           +SV E  PP+T V  + A  P  +   G   +      +    + F + P +G++     
Sbjct: 245 VSVPENSPPNTPVIRLNASDPD-EGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGA 303

Query: 131 LDRERRDHYSF-VAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQ---LDVSELSP 181
           LD E    Y   V A  LG     A  +V + V D ND+ P   L S+    ++VSE +P
Sbjct: 304 LDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAP 363

Query: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
           PG    L    D D+GL                       +++ R  G +P  L      
Sbjct: 364 PGYVIALVRVSDRDSGLNG---------------------RVQCRLLGNVPFRL-----Q 397

Query: 242 PLEPLDLVLLR-RLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDE 300
             E    +L+  RLDRE+   + L I+A DGG P      S  + + DENDN P F +  
Sbjct: 398 EYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPY 457

Query: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
           Y+  V+E+  PGA +  V A D DLG NG V Y +   QV         +    Y ++  
Sbjct: 458 YQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRD-------MPVFTYVSINP 510

Query: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
            SG +   R  + E     +  V A+DGG     +   V + +LDVNDN P I    L  
Sbjct: 511 NSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLIN 570

Query: 421 G-GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFA 479
           G     +   +  G  V  V   D D          GE      +G ++  +  G+  F 
Sbjct: 571 GTAEVYIPRNSGIGYLVTVVKAEDYD---------EGE------NGRVTYDMTEGDRGFF 615

Query: 480 LLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLND 534
            +      V      G     S+  YEL++VA D G   LS    +L+ ++   D
Sbjct: 616 EIDQVNGEVRTTRTFG---ESSKSSYELIVVAHDHGKTSLSASALVLIYLSPALD 667



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 91/330 (27%), Positives = 141/330 (42%), Gaps = 52/330 (15%)

Query: 362 SGVVRVWRPLDRE--AQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLT 419
           SG++   + +DR+   +   + ++      +  E+  ++V I   D+NDN P+     + 
Sbjct: 78  SGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK--DLNDNAPSFPAAQIE 135

Query: 420 EGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGS------ISLSLEG 473
                 +SE A PG  +   S  D D         +G  GV   + +      + +   G
Sbjct: 136 ----LEISEAASPGTRIPLDSAYDPD---------SGSFGVQTYELTPNELFGLEIKTRG 182

Query: 474 GEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLN 533
               FA L           VE  LDRE++  Y   + A D G PP      L ++V D N
Sbjct: 183 DGSRFAEL----------VVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSN 232

Query: 534 DQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQ 593
           D  P+FS+  Y  SV E + P T V+ ++ASD DE  +      +           G + 
Sbjct: 233 DNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSF----------YGYVN 282

Query: 594 SKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITV 653
            +   T E    F ID  SG ++    LD E     EL V A+DLG   + A C V+++V
Sbjct: 283 DR---TREL---FQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSV 336

Query: 654 DDVNDNEPIFWRQVYNA---TIAEHAPVGH 680
            D NDN P+      N+    ++E AP G+
Sbjct: 337 LDTNDNPPVINLLSVNSELVEVSESAPPGY 366


>gi|14270484 protocadherin gamma subfamily A, 8 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  241 bits (615), Expect = 2e-63
 Identities = 177/556 (31%), Positives = 276/556 (49%), Gaps = 80/556 (14%)

Query: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFP 168
           F ++P +G + TA R+DRE     S      +  +V+       VEI + D+ND++P+F 
Sbjct: 75  FALNPRSGSLITAGRIDREELCAQSPRCLININTLVEDKGKLFGVEIEIIDINDNNPKFQ 134

Query: 169 LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
           ++ L++ ++E++ PG  + LP A DPD G+ S Q Y L              F L  +T 
Sbjct: 135 VEDLEVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQL---------SPNHHFSLDVQT- 184

Query: 229 GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
                    G +  + P +LVL R LDREE AAH L + A DGG+P R+  + + + VLD
Sbjct: 185 ---------GDNGAINP-ELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVLD 234

Query: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVR---ARQVPGAGS 345
            NDN PVF    YR  V E+  PG  +  V A+D D G NG V Y  R    +Q P    
Sbjct: 235 TNDNAPVFPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTP---- 290

Query: 346 GGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405
                     F + E +G + + + LD E  +++++ ++A D GA   +   ++ I+V D
Sbjct: 291 ---------LFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGA--LLGRTKLLISVED 339

Query: 406 VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDG 465
           VNDNRP + +  L     + V E + PG  +A +SV D D          G++     D 
Sbjct: 340 VNDNRPEVIITSL----FSPVLENSLPGTVIAFLSVHDQDSG------KNGQVVCYTRD- 388

Query: 466 SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
           ++   LE   G++          + L     LDRE+  +Y + ++A+D G+PPLSTE  +
Sbjct: 389 NLPFKLEKSIGNY----------YRLVTRKYLDRENVSIYNITVMASDLGTPPLSTETQI 438

Query: 526 LLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSA 585
            L VAD+ND PP F    Y A + E    G  +  ++A D D    ++A + Y+V +   
Sbjct: 439 ALHVADINDNPPTFPHASYSAYILENNLRGASIFSLTAHDPD--SQENAQVTYSVTE--- 493

Query: 586 PCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSA 645
                +LQ      A      +I+S++G +  +++ D E    ++L V A D G+PPLS+
Sbjct: 494 ----DTLQG-----APLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTASDSGDPPLSS 544

Query: 646 TCLVSITVDDVNDNEP 661
              +S+ V D NDN P
Sbjct: 545 NMSLSLFVLDQNDNAP 560



 Score =  131 bits (329), Expect = 2e-30
 Identities = 128/442 (28%), Positives = 180/442 (40%), Gaps = 75/442 (16%)

Query: 248 LVLLRRLDREEAAAH------RLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
           L+   R+DREE  A        +     D G+     L  VE+ ++D NDN P F+ ++ 
Sbjct: 84  LITAGRIDREELCAQSPRCLININTLVEDKGK-----LFGVEIEIIDINDNNPKFQVEDL 138

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
              + E A PGA      A D D+G N    Y +            G  G      V E 
Sbjct: 139 EVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLSPNHHFSLDVQTGDNGAINPELVLE- 197

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLTE 420
                  R LDRE +A H LV+ A DGG  P  +TVR+ + VLD NDN P   H ++   
Sbjct: 198 -------RALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRV- 249

Query: 421 GGVARVSEGARPGDYVARVSVSDAD----GDWEKEDEATGELGVGLGDGSISLSLEGGEG 476
               +V E   PG  +  V+ SD D    G    +     E    L      L+   GE 
Sbjct: 250 ----KVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTPL----FQLNENTGE- 300

Query: 477 DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
                         + +   LD E    YE+ + A D G+  L     LL+ V D+ND  
Sbjct: 301 --------------ISIAKSLDYEECSFYEMEIQAEDVGA--LLGRTKLLISVEDVNDNR 344

Query: 537 PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
           P        + V E + PGTV+ ++S  D D +G +   + YT   L             
Sbjct: 345 PEVIITSLFSPVLENSLPGTVIAFLSVHDQD-SGKNGQVVCYTRDNLP------------ 391

Query: 597 VHTAECGPSFAIDSESG---AISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITV 653
                    F ++   G    + T + LDRE      + V+A DLG PPLS    +++ V
Sbjct: 392 ---------FKLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHV 442

Query: 654 DDVNDNEPIFWRQVYNATIAEH 675
            D+NDN P F    Y+A I E+
Sbjct: 443 ADINDNPPTFPHASYSAYILEN 464



 Score =  124 bits (312), Expect = 2e-28
 Identities = 149/546 (27%), Positives = 225/546 (41%), Gaps = 96/546 (17%)

Query: 129 RRLDRERRDHYSFVAATLLG------AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           R LDRE    +  V     G      + V++ + V D ND++P FP    ++ V E  PP
Sbjct: 198 RALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPP 257

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           GT      A DPD G+     Y   + ++       P FQL   T               
Sbjct: 258 GTRLLTVTASDPDEGINGKVAYKFRKINEKQT----PLFQLNENTG-------------- 299

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWD-GGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
               ++ + + LD EE + + ++I+A D G    RT LL   + V D NDN P       
Sbjct: 300 ----EISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLL---ISVEDVNDNRPEVIITSL 352

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
            + V E++ PG  +  +   D+D G NG V    R               D   F +E+ 
Sbjct: 353 FSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTR---------------DNLPFKLEKS 397

Query: 362 SG-----VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVL 416
            G     V R +  LDRE  + + + V A D G  P     ++++ V D+NDN P     
Sbjct: 398 IGNYYRLVTRKY--LDRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPT---- 451

Query: 417 FLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEG 476
           F      A + E    G  +  ++  D D       +   ++   + + +    L+G   
Sbjct: 452 FPHASYSAYILENNLRGASIFSLTAHDPDS------QENAQVTYSVTEDT----LQGAPL 501

Query: 477 DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
              +      GV +       + + RDL +LL+ A+D+G PPLS+  +L L V D ND  
Sbjct: 502 SSYISINSDTGVLYALQSFDYE-QIRDL-QLLVTASDSGDPPLSSNMSLSLFVLDQNDNA 559

Query: 537 P--LFSQQHYKASVSEAAAP-----GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL 589
           P  L+       S     AP     G +V  V A D D     +AWL Y +++ S P   
Sbjct: 560 PEILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSG--QNAWLSYRLLKASEP--- 614

Query: 590 GSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLV 649
             L S  +HT E   + A+            LDR+  +   L V  QD G+PPLSAT  +
Sbjct: 615 -GLFSVGLHTGEVRTARAL------------LDRDALKQ-SLVVAVQDHGQPPLSATVTL 660

Query: 650 SITVDD 655
           ++ V D
Sbjct: 661 TVAVAD 666



 Score =  118 bits (295), Expect = 2e-26
 Identities = 132/476 (27%), Positives = 191/476 (40%), Gaps = 73/476 (15%)

Query: 71  LSVDEGLPPDTLVGDIRAGLPAAQQQEGSGF-FLSEDSDDSPLLDDFHVHPDTGIIRTAR 129
           + V E +PP T +  + A  P         + F   +   +PL   F ++ +TG I  A+
Sbjct: 249 VKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTPL---FQLNENTGEISIAK 305

Query: 130 RLDRERRDHYSF-VAATLLGAVV---QVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTA 185
            LD E    Y   + A  +GA++   ++ I V DVND+ P   + SL   V E S PGT 
Sbjct: 306 SLDYEECSFYEMEIQAEDVGALLGRTKLLISVEDVNDNRPEVIITSLFSPVLENSLPGTV 365

Query: 186 FRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEP 245
                 HD D+G                        Q+   T   LP  L     +    
Sbjct: 366 IAFLSVHDQDSGKNG---------------------QVVCYTRDNLPFKLEKSIGNYYR- 403

Query: 246 LDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAV 305
             LV  + LDRE  + + + + A D G P  +    + L V D NDNPP F    Y A +
Sbjct: 404 --LVTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYI 461

Query: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVV 365
            E+   GA +  + A D D   N  V YSV    + GA         ++Y ++   +GV+
Sbjct: 462 LENNLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGAPL-------SSYISINSDTGVL 514

Query: 366 RVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLTEG--G 422
              +  D E     QL+V A D G  P  + + +S+ VLD NDN P I +    T+G  G
Sbjct: 515 YALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPEILYPALPTDGSTG 574

Query: 423 VARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLP 482
           V      A  G  V +V   D D                        S +     + LL 
Sbjct: 575 VELAPRSAERGYLVTKVVAVDRD------------------------SGQNAWLSYRLLK 610

Query: 483 GGPPGVFFLCVEGPLDRESRDLYE-------LLLVATDAGSPPLSTEETLLLRVAD 531
              PG+F + +     R +R L +       L++   D G PPLS   TL + VAD
Sbjct: 611 ASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 666



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 53/190 (27%), Positives = 83/190 (43%), Gaps = 32/190 (16%)

Query: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
           + + D+ND  P F  +  +  ++E A PG       A D D                   
Sbjct: 121 IEIIDINDNNPKFQVEDLEVKINEIAVPGARYPLPEAVDPD------------------- 161

Query: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTI-------RTLDREVQEAVELKVVAQDLG 639
             + SLQS  +        F++D ++G    I       R LDRE + A  L + A D G
Sbjct: 162 VGVNSLQSYQLSPNH---HFSLDVQTGDNGAINPELVLERALDREEEAAHHLVLTASDGG 218

Query: 640 EPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISA---QVAFVKIK 696
           +PP S+T  + +TV D NDN P+F   +Y   + E+ P G   L + ++   +    K+ 
Sbjct: 219 KPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVA 278

Query: 697 QKQKEIQEKQ 706
            K ++I EKQ
Sbjct: 279 YKFRKINEKQ 288


>gi|7662056 protocadherin gamma subfamily A, 8 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  241 bits (615), Expect = 2e-63
 Identities = 177/556 (31%), Positives = 276/556 (49%), Gaps = 80/556 (14%)

Query: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFP 168
           F ++P +G + TA R+DRE     S      +  +V+       VEI + D+ND++P+F 
Sbjct: 75  FALNPRSGSLITAGRIDREELCAQSPRCLININTLVEDKGKLFGVEIEIIDINDNNPKFQ 134

Query: 169 LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
           ++ L++ ++E++ PG  + LP A DPD G+ S Q Y L              F L  +T 
Sbjct: 135 VEDLEVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQL---------SPNHHFSLDVQT- 184

Query: 229 GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
                    G +  + P +LVL R LDREE AAH L + A DGG+P R+  + + + VLD
Sbjct: 185 ---------GDNGAINP-ELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVLD 234

Query: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVR---ARQVPGAGS 345
            NDN PVF    YR  V E+  PG  +  V A+D D G NG V Y  R    +Q P    
Sbjct: 235 TNDNAPVFPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTP---- 290

Query: 346 GGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405
                     F + E +G + + + LD E  +++++ ++A D GA   +   ++ I+V D
Sbjct: 291 ---------LFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGA--LLGRTKLLISVED 339

Query: 406 VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDG 465
           VNDNRP + +  L     + V E + PG  +A +SV D D          G++     D 
Sbjct: 340 VNDNRPEVIITSL----FSPVLENSLPGTVIAFLSVHDQDSG------KNGQVVCYTRD- 388

Query: 466 SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETL 525
           ++   LE   G++          + L     LDRE+  +Y + ++A+D G+PPLSTE  +
Sbjct: 389 NLPFKLEKSIGNY----------YRLVTRKYLDRENVSIYNITVMASDLGTPPLSTETQI 438

Query: 526 LLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSA 585
            L VAD+ND PP F    Y A + E    G  +  ++A D D    ++A + Y+V +   
Sbjct: 439 ALHVADINDNPPTFPHASYSAYILENNLRGASIFSLTAHDPD--SQENAQVTYSVTE--- 493

Query: 586 PCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSA 645
                +LQ      A      +I+S++G +  +++ D E    ++L V A D G+PPLS+
Sbjct: 494 ----DTLQG-----APLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTASDSGDPPLSS 544

Query: 646 TCLVSITVDDVNDNEP 661
              +S+ V D NDN P
Sbjct: 545 NMSLSLFVLDQNDNAP 560



 Score =  131 bits (329), Expect = 2e-30
 Identities = 128/442 (28%), Positives = 180/442 (40%), Gaps = 75/442 (16%)

Query: 248 LVLLRRLDREEAAAH------RLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
           L+   R+DREE  A        +     D G+     L  VE+ ++D NDN P F+ ++ 
Sbjct: 84  LITAGRIDREELCAQSPRCLININTLVEDKGK-----LFGVEIEIIDINDNNPKFQVEDL 138

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
              + E A PGA      A D D+G N    Y +            G  G      V E 
Sbjct: 139 EVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLSPNHHFSLDVQTGDNGAINPELVLE- 197

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLTE 420
                  R LDRE +A H LV+ A DGG  P  +TVR+ + VLD NDN P   H ++   
Sbjct: 198 -------RALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRV- 249

Query: 421 GGVARVSEGARPGDYVARVSVSDAD----GDWEKEDEATGELGVGLGDGSISLSLEGGEG 476
               +V E   PG  +  V+ SD D    G    +     E    L      L+   GE 
Sbjct: 250 ----KVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTPL----FQLNENTGE- 300

Query: 477 DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
                         + +   LD E    YE+ + A D G+  L     LL+ V D+ND  
Sbjct: 301 --------------ISIAKSLDYEECSFYEMEIQAEDVGA--LLGRTKLLISVEDVNDNR 344

Query: 537 PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
           P        + V E + PGTV+ ++S  D D +G +   + YT   L             
Sbjct: 345 PEVIITSLFSPVLENSLPGTVIAFLSVHDQD-SGKNGQVVCYTRDNLP------------ 391

Query: 597 VHTAECGPSFAIDSESG---AISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITV 653
                    F ++   G    + T + LDRE      + V+A DLG PPLS    +++ V
Sbjct: 392 ---------FKLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHV 442

Query: 654 DDVNDNEPIFWRQVYNATIAEH 675
            D+NDN P F    Y+A I E+
Sbjct: 443 ADINDNPPTFPHASYSAYILEN 464



 Score =  124 bits (312), Expect = 2e-28
 Identities = 149/546 (27%), Positives = 225/546 (41%), Gaps = 96/546 (17%)

Query: 129 RRLDRERRDHYSFVAATLLG------AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           R LDRE    +  V     G      + V++ + V D ND++P FP    ++ V E  PP
Sbjct: 198 RALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPP 257

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           GT      A DPD G+     Y   + ++       P FQL   T               
Sbjct: 258 GTRLLTVTASDPDEGINGKVAYKFRKINEKQT----PLFQLNENTG-------------- 299

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWD-GGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
               ++ + + LD EE + + ++I+A D G    RT LL   + V D NDN P       
Sbjct: 300 ----EISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLL---ISVEDVNDNRPEVIITSL 352

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
            + V E++ PG  +  +   D+D G NG V    R               D   F +E+ 
Sbjct: 353 FSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTR---------------DNLPFKLEKS 397

Query: 362 SG-----VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVL 416
            G     V R +  LDRE  + + + V A D G  P     ++++ V D+NDN P     
Sbjct: 398 IGNYYRLVTRKY--LDRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPT---- 451

Query: 417 FLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEG 476
           F      A + E    G  +  ++  D D       +   ++   + + +    L+G   
Sbjct: 452 FPHASYSAYILENNLRGASIFSLTAHDPDS------QENAQVTYSVTEDT----LQGAPL 501

Query: 477 DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
              +      GV +       + + RDL +LL+ A+D+G PPLS+  +L L V D ND  
Sbjct: 502 SSYISINSDTGVLYALQSFDYE-QIRDL-QLLVTASDSGDPPLSSNMSLSLFVLDQNDNA 559

Query: 537 P--LFSQQHYKASVSEAAAP-----GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL 589
           P  L+       S     AP     G +V  V A D D     +AWL Y +++ S P   
Sbjct: 560 PEILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSG--QNAWLSYRLLKASEP--- 614

Query: 590 GSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLV 649
             L S  +HT E   + A+            LDR+  +   L V  QD G+PPLSAT  +
Sbjct: 615 -GLFSVGLHTGEVRTARAL------------LDRDALKQ-SLVVAVQDHGQPPLSATVTL 660

Query: 650 SITVDD 655
           ++ V D
Sbjct: 661 TVAVAD 666



 Score =  118 bits (295), Expect = 2e-26
 Identities = 132/476 (27%), Positives = 191/476 (40%), Gaps = 73/476 (15%)

Query: 71  LSVDEGLPPDTLVGDIRAGLPAAQQQEGSGF-FLSEDSDDSPLLDDFHVHPDTGIIRTAR 129
           + V E +PP T +  + A  P         + F   +   +PL   F ++ +TG I  A+
Sbjct: 249 VKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTPL---FQLNENTGEISIAK 305

Query: 130 RLDRERRDHYSF-VAATLLGAVV---QVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTA 185
            LD E    Y   + A  +GA++   ++ I V DVND+ P   + SL   V E S PGT 
Sbjct: 306 SLDYEECSFYEMEIQAEDVGALLGRTKLLISVEDVNDNRPEVIITSLFSPVLENSLPGTV 365

Query: 186 FRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEP 245
                 HD D+G                        Q+   T   LP  L     +    
Sbjct: 366 IAFLSVHDQDSGKNG---------------------QVVCYTRDNLPFKLEKSIGNYYR- 403

Query: 246 LDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAV 305
             LV  + LDRE  + + + + A D G P  +    + L V D NDNPP F    Y A +
Sbjct: 404 --LVTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYI 461

Query: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVV 365
            E+   GA +  + A D D   N  V YSV    + GA         ++Y ++   +GV+
Sbjct: 462 LENNLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGAPL-------SSYISINSDTGVL 514

Query: 366 RVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLTEG--G 422
              +  D E     QL+V A D G  P  + + +S+ VLD NDN P I +    T+G  G
Sbjct: 515 YALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPEILYPALPTDGSTG 574

Query: 423 VARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLP 482
           V      A  G  V +V   D D                        S +     + LL 
Sbjct: 575 VELAPRSAERGYLVTKVVAVDRD------------------------SGQNAWLSYRLLK 610

Query: 483 GGPPGVFFLCVEGPLDRESRDLYE-------LLLVATDAGSPPLSTEETLLLRVAD 531
              PG+F + +     R +R L +       L++   D G PPLS   TL + VAD
Sbjct: 611 ASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 666



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 53/190 (27%), Positives = 83/190 (43%), Gaps = 32/190 (16%)

Query: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
           + + D+ND  P F  +  +  ++E A PG       A D D                   
Sbjct: 121 IEIIDINDNNPKFQVEDLEVKINEIAVPGARYPLPEAVDPD------------------- 161

Query: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTI-------RTLDREVQEAVELKVVAQDLG 639
             + SLQS  +        F++D ++G    I       R LDRE + A  L + A D G
Sbjct: 162 VGVNSLQSYQLSPNH---HFSLDVQTGDNGAINPELVLERALDREEEAAHHLVLTASDGG 218

Query: 640 EPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISA---QVAFVKIK 696
           +PP S+T  + +TV D NDN P+F   +Y   + E+ P G   L + ++   +    K+ 
Sbjct: 219 KPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVA 278

Query: 697 QKQKEIQEKQ 706
            K ++I EKQ
Sbjct: 279 YKFRKINEKQ 288


>gi|14277677 protocadherin gamma subfamily C, 3 isoform 2 precursor
           [Homo sapiens]
          Length = 863

 Score =  240 bits (613), Expect = 3e-63
 Identities = 187/553 (33%), Positives = 265/553 (47%), Gaps = 71/553 (12%)

Query: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFP 168
           F V+ +TG +    RLDRE            L  VV+       VE+ + D+ND++P FP
Sbjct: 77  FEVNRETGEMFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFP 136

Query: 169 LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
              ++L++SE   PGT F L  AHDPD G  S Q Y L +           +F LR +T 
Sbjct: 137 TQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSR---------NEYFALRVQT- 186

Query: 229 GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
                          +  +LVL R LDRE   + +L + A DGG P  +  L + ++VLD
Sbjct: 187 ----------REDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLD 236

Query: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
            NDN PVF Q  YRA V EDA  G  V +V ATD D GPNG + YS         GS   
Sbjct: 237 ANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSF--------GSHNR 288

Query: 349 ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVND 408
           A G    FA++ ++G++ +   LD E    H++ ++A+D GA PE A  +V + V+DVND
Sbjct: 289 A-GVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVND 347

Query: 409 NRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS 468
           N P I V  +     + V E A  G  +A +SV+D D    +    T E+  GL   S++
Sbjct: 348 NAPEITVTSV----YSPVPEDAPLGTVIALLSVTDLDAG--ENGLVTCEVPPGL-PFSLT 400

Query: 469 LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLR 528
            SL+                F L     LDRE+   Y L + A DAG+P LS    + ++
Sbjct: 401 SSLK--------------NYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQ 446

Query: 529 VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
           V+D+ND PP  SQ  Y   + E   PG  ++ +S  D D     +A L + +++  A   
Sbjct: 447 VSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPD--APQNARLSFFLLEQGA--- 501

Query: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
                     T   G  F I+ ++G +S++  LD E +   EL     D G P L+    
Sbjct: 502 ---------ETGLVGRYFTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTPVLATNIS 552

Query: 649 VSITVDDVNDNEP 661
           V+I V D NDN P
Sbjct: 553 VNIFVTDRNDNAP 565



 Score =  124 bits (311), Expect = 3e-28
 Identities = 124/418 (29%), Positives = 174/418 (41%), Gaps = 67/418 (16%)

Query: 279 LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
           L SVE+ + D NDN P F   E +  + E   PG       A D D+G N    Y +   
Sbjct: 118 LFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSRN 177

Query: 339 QVPGAGSGGGALGDAAYFAVEELS-------GVVRVWRPLDREAQAWHQLVVEARDGGAE 391
           +               YFA+   +         + + R LDRE +   QLV+ A DGG  
Sbjct: 178 E---------------YFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTP 222

Query: 392 PEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKE 451
              A++ + I VLD NDN P  +         ARV E A  G  V +V  +D D      
Sbjct: 223 ALSASLPIHIKVLDANDNAPVFNQSLYR----ARVLEDAPSGTRVVQVLATDLD------ 272

Query: 452 DEATGELGVGLGDGSISLSLEGGEGDFAL-LPGGPPGVFFLCVEGPLDRESRDLYELLLV 510
           +   GE+    G    S +  G    FAL L  G      L ++G LD E   L+E+ + 
Sbjct: 273 EGPNGEIIYSFG----SHNRAGVRQLFALDLVTG-----MLTIKGRLDFEDTKLHEIYIQ 323

Query: 511 ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
           A D G+ P      +L+ V D+ND  P  +     + V E A  GTV+  +S +D D AG
Sbjct: 324 AKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLD-AG 382

Query: 571 SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQE 627
            +       +V    P  L                F++ S      T++T   LDRE   
Sbjct: 383 ENG------LVTCEVPPGL---------------PFSLTSSLKNYFTLKTSADLDRETVP 421

Query: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
              L + A+D G P LSA  +V + V D+NDN P   +  Y+  I E+   G   L L
Sbjct: 422 EYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSSYDVYIEENNLPGAPILNL 479



 Score =  114 bits (284), Expect = 4e-25
 Identities = 148/538 (27%), Positives = 206/538 (38%), Gaps = 80/538 (14%)

Query: 129 RRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           R LDRER      V   L      L A + + I+V D ND++P F     +  V E +P 
Sbjct: 200 RALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPS 259

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           GT     +A D D G     G  +       +      F L           L+ G    
Sbjct: 260 GTRVVQVLATDLDEG---PNGEIIYSFGSHNRAGVRQLFAL----------DLVTGM--- 303

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYR 302
                L +  RLD E+   H + I+A D G         V + V+D NDN P        
Sbjct: 304 -----LTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVY 358

Query: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAG-SGGGALGDAAYFAVEEL 361
           + V EDA  G  +  +  TD D G NG V   V     PG   S   +L +  YF ++  
Sbjct: 359 SPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVP----PGLPFSLTSSLKN--YFTLKTS 412

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +        LDRE    + L + ARD G     A   V + V D+NDN P          
Sbjct: 413 AD-------LDRETVPEYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSS----QSS 461

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
               + E   PG  +  +SV      W+ +      L   L +      L G    F + 
Sbjct: 462 YDVYIEENNLPGAPILNLSV------WDPDAPQNARLSFFLLEQGAETGLVGRY--FTI- 512

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
                G+    V  PLD E R  +EL    +D G+P L+T  ++ + V D ND  P    
Sbjct: 513 -NRDNGIVSSLV--PLDYEDRREFELTAHISDGGTPVLATNISVNIFVTDRNDNAPQVLY 569

Query: 542 QHYKASVSEAAAPGT----VVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
                S  E    GT    +V  V   DAD     +AWL Y++        LGS    + 
Sbjct: 570 PRPGGSSVEMLPRGTSAGHLVSRVVGWDAD--AGHNAWLSYSL--------LGSPNQSL- 618

Query: 598 HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDD 655
                   FAI   +G IST R +         L V+ +D GEP LS T  ++++V +
Sbjct: 619 --------FAIGLHTGQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTE 668



 Score =  106 bits (264), Expect = 8e-23
 Identities = 117/418 (27%), Positives = 163/418 (38%), Gaps = 58/418 (13%)

Query: 122 TGIIRTARRLDRE-RRDHYSFV-----AATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLD 175
           TG++    RLD E  + H  ++      A   GA  +V + V DVND++P   + S+   
Sbjct: 301 TGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSP 360

Query: 176 VSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPL 235
           V E +P GT   L    D DAG     G    +                   P  LP  L
Sbjct: 361 VPEDAPLGTVIALLSVTDLDAG---ENGLVTCE------------------VPPGLPFSL 399

Query: 236 LPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPV 295
              +SS      L     LDRE    + L I A D G P  + L  V ++V D NDNPP 
Sbjct: 400 ---TSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQ 456

Query: 296 FEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAY 355
             Q  Y   + E+  PGA +  +   D D   N  + + +  +     G+  G +G   Y
Sbjct: 457 SSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQ-----GAETGLVG--RY 509

Query: 356 FAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHV 415
           F +   +G+V    PLD E +   +L     DGG       + V+I V D NDN P   V
Sbjct: 510 FTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTPVLATNISVNIFVTDRNDNAP--QV 567

Query: 416 LFLTEGG--VARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEG 473
           L+   GG  V  +  G   G  V+RV   DAD                  +  +S SL G
Sbjct: 568 LYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAG---------------HNAWLSYSLLG 612

Query: 474 GEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVAD 531
                    G   G   +    P+         L ++  D G P LST  TL + V +
Sbjct: 613 SPNQSLFAIGLHTGQ--ISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTE 668



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 52/162 (32%), Positives = 76/162 (46%), Gaps = 15/162 (9%)

Query: 529 VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
           + D+ND  P F  Q  K  +SEA APGT     SA D D   +          +LS    
Sbjct: 125 IQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNS-----LQTYELSR--- 176

Query: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
                +  V T E    +A       +   R LDRE + +++L + A D G P LSA+  
Sbjct: 177 -NEYFALRVQTREDSTKYA------ELVLERALDREREPSLQLVLTALDGGTPALSASLP 229

Query: 649 VSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISAQV 690
           + I V D NDN P+F + +Y A + E AP G   +Q+++  +
Sbjct: 230 IHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDL 271


>gi|14277675 protocadherin gamma subfamily C, 3 isoform 1 precursor
           [Homo sapiens]
          Length = 934

 Score =  240 bits (613), Expect = 3e-63
 Identities = 187/553 (33%), Positives = 265/553 (47%), Gaps = 71/553 (12%)

Query: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFP 168
           F V+ +TG +    RLDRE            L  VV+       VE+ + D+ND++P FP
Sbjct: 77  FEVNRETGEMFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFP 136

Query: 169 LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
              ++L++SE   PGT F L  AHDPD G  S Q Y L +           +F LR +T 
Sbjct: 137 TQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSR---------NEYFALRVQT- 186

Query: 229 GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
                          +  +LVL R LDRE   + +L + A DGG P  +  L + ++VLD
Sbjct: 187 ----------REDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLD 236

Query: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
            NDN PVF Q  YRA V EDA  G  V +V ATD D GPNG + YS         GS   
Sbjct: 237 ANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSF--------GSHNR 288

Query: 349 ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVND 408
           A G    FA++ ++G++ +   LD E    H++ ++A+D GA PE A  +V + V+DVND
Sbjct: 289 A-GVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVND 347

Query: 409 NRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS 468
           N P I V  +     + V E A  G  +A +SV+D D    +    T E+  GL   S++
Sbjct: 348 NAPEITVTSV----YSPVPEDAPLGTVIALLSVTDLDAG--ENGLVTCEVPPGL-PFSLT 400

Query: 469 LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLR 528
            SL+                F L     LDRE+   Y L + A DAG+P LS    + ++
Sbjct: 401 SSLK--------------NYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQ 446

Query: 529 VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
           V+D+ND PP  SQ  Y   + E   PG  ++ +S  D D     +A L + +++  A   
Sbjct: 447 VSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPD--APQNARLSFFLLEQGA--- 501

Query: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
                     T   G  F I+ ++G +S++  LD E +   EL     D G P L+    
Sbjct: 502 ---------ETGLVGRYFTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTPVLATNIS 552

Query: 649 VSITVDDVNDNEP 661
           V+I V D NDN P
Sbjct: 553 VNIFVTDRNDNAP 565



 Score =  124 bits (311), Expect = 3e-28
 Identities = 124/418 (29%), Positives = 174/418 (41%), Gaps = 67/418 (16%)

Query: 279 LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
           L SVE+ + D NDN P F   E +  + E   PG       A D D+G N    Y +   
Sbjct: 118 LFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSRN 177

Query: 339 QVPGAGSGGGALGDAAYFAVEELS-------GVVRVWRPLDREAQAWHQLVVEARDGGAE 391
           +               YFA+   +         + + R LDRE +   QLV+ A DGG  
Sbjct: 178 E---------------YFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTP 222

Query: 392 PEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKE 451
              A++ + I VLD NDN P  +         ARV E A  G  V +V  +D D      
Sbjct: 223 ALSASLPIHIKVLDANDNAPVFNQSLYR----ARVLEDAPSGTRVVQVLATDLD------ 272

Query: 452 DEATGELGVGLGDGSISLSLEGGEGDFAL-LPGGPPGVFFLCVEGPLDRESRDLYELLLV 510
           +   GE+    G    S +  G    FAL L  G      L ++G LD E   L+E+ + 
Sbjct: 273 EGPNGEIIYSFG----SHNRAGVRQLFALDLVTG-----MLTIKGRLDFEDTKLHEIYIQ 323

Query: 511 ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
           A D G+ P      +L+ V D+ND  P  +     + V E A  GTV+  +S +D D AG
Sbjct: 324 AKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLD-AG 382

Query: 571 SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT---LDREVQE 627
            +       +V    P  L                F++ S      T++T   LDRE   
Sbjct: 383 ENG------LVTCEVPPGL---------------PFSLTSSLKNYFTLKTSADLDRETVP 421

Query: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
              L + A+D G P LSA  +V + V D+NDN P   +  Y+  I E+   G   L L
Sbjct: 422 EYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSSYDVYIEENNLPGAPILNL 479



 Score =  114 bits (284), Expect = 4e-25
 Identities = 148/538 (27%), Positives = 206/538 (38%), Gaps = 80/538 (14%)

Query: 129 RRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           R LDRER      V   L      L A + + I+V D ND++P F     +  V E +P 
Sbjct: 200 RALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPS 259

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           GT     +A D D G     G  +       +      F L           L+ G    
Sbjct: 260 GTRVVQVLATDLDEG---PNGEIIYSFGSHNRAGVRQLFAL----------DLVTGM--- 303

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYR 302
                L +  RLD E+   H + I+A D G         V + V+D NDN P        
Sbjct: 304 -----LTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVY 358

Query: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAG-SGGGALGDAAYFAVEEL 361
           + V EDA  G  +  +  TD D G NG V   V     PG   S   +L +  YF ++  
Sbjct: 359 SPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVP----PGLPFSLTSSLKN--YFTLKTS 412

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
           +        LDRE    + L + ARD G     A   V + V D+NDN P          
Sbjct: 413 AD-------LDRETVPEYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSS----QSS 461

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
               + E   PG  +  +SV      W+ +      L   L +      L G    F + 
Sbjct: 462 YDVYIEENNLPGAPILNLSV------WDPDAPQNARLSFFLLEQGAETGLVGRY--FTI- 512

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
                G+    V  PLD E R  +EL    +D G+P L+T  ++ + V D ND  P    
Sbjct: 513 -NRDNGIVSSLV--PLDYEDRREFELTAHISDGGTPVLATNISVNIFVTDRNDNAPQVLY 569

Query: 542 QHYKASVSEAAAPGT----VVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
                S  E    GT    +V  V   DAD     +AWL Y++        LGS    + 
Sbjct: 570 PRPGGSSVEMLPRGTSAGHLVSRVVGWDAD--AGHNAWLSYSL--------LGSPNQSL- 618

Query: 598 HTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDD 655
                   FAI   +G IST R +         L V+ +D GEP LS T  ++++V +
Sbjct: 619 --------FAIGLHTGQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTE 668



 Score =  106 bits (264), Expect = 8e-23
 Identities = 117/418 (27%), Positives = 163/418 (38%), Gaps = 58/418 (13%)

Query: 122 TGIIRTARRLDRE-RRDHYSFV-----AATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLD 175
           TG++    RLD E  + H  ++      A   GA  +V + V DVND++P   + S+   
Sbjct: 301 TGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSP 360

Query: 176 VSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPL 235
           V E +P GT   L    D DAG     G    +                   P  LP  L
Sbjct: 361 VPEDAPLGTVIALLSVTDLDAG---ENGLVTCE------------------VPPGLPFSL 399

Query: 236 LPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPV 295
              +SS      L     LDRE    + L I A D G P  + L  V ++V D NDNPP 
Sbjct: 400 ---TSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQ 456

Query: 296 FEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAY 355
             Q  Y   + E+  PGA +  +   D D   N  + + +  +     G+  G +G   Y
Sbjct: 457 SSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQ-----GAETGLVG--RY 509

Query: 356 FAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHV 415
           F +   +G+V    PLD E +   +L     DGG       + V+I V D NDN P   V
Sbjct: 510 FTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTPVLATNISVNIFVTDRNDNAP--QV 567

Query: 416 LFLTEGG--VARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEG 473
           L+   GG  V  +  G   G  V+RV   DAD                  +  +S SL G
Sbjct: 568 LYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAG---------------HNAWLSYSLLG 612

Query: 474 GEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVAD 531
                    G   G   +    P+         L ++  D G P LST  TL + V +
Sbjct: 613 SPNQSLFAIGLHTGQ--ISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTE 668



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 52/162 (32%), Positives = 76/162 (46%), Gaps = 15/162 (9%)

Query: 529 VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
           + D+ND  P F  Q  K  +SEA APGT     SA D D   +          +LS    
Sbjct: 125 IQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNS-----LQTYELSR--- 176

Query: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
                +  V T E    +A       +   R LDRE + +++L + A D G P LSA+  
Sbjct: 177 -NEYFALRVQTREDSTKYA------ELVLERALDREREPSLQLVLTALDGGTPALSASLP 229

Query: 649 VSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISAQV 690
           + I V D NDN P+F + +Y A + E AP G   +Q+++  +
Sbjct: 230 IHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDL 271


>gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precursor
           [Homo sapiens]
          Length = 818

 Score =  240 bits (613), Expect = 3e-63
 Identities = 188/597 (31%), Positives = 275/597 (46%), Gaps = 85/597 (14%)

Query: 73  VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
           + E +P  ++VG++   L  + Q+  +       S + P    F V  ++G +  + RLD
Sbjct: 37  IPEEMPKGSVVGNLATDLGFSVQELPTRKL--RVSSEKPY---FTVSAESGELLVSSRLD 91

Query: 133 RERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTA 185
           RE         A    AV +       V + + D+NDH+P+F  +S +L +SE + PGT 
Sbjct: 92  REEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTR 151

Query: 186 FRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEP 245
           F L VA D D GL S Q Y L            P F L  +           GS  P   
Sbjct: 152 FILEVAEDADIGLNSLQKYKL---------SLNPSFSLIIKEKQD-------GSKYP--- 192

Query: 246 LDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAV 305
            +L L + LDRE+ + HRL + A DGG P  +G   + ++V D NDNPPVF +D YR ++
Sbjct: 193 -ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSL 251

Query: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYS-VRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           RE+  PG  V +V ATD+D G N  + YS  R  Q+               F++   SG 
Sbjct: 252 RENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI---------------FSLNSKSGE 296

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVA 424
           +   + LD E    + +VVE RDGG    VA   V I + D NDN P +    L E    
Sbjct: 297 ITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQDENDNSPEVTFHSLLE---- 350

Query: 425 RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGG 484
            + E A PG  +A + + D D         +GE      +G ++  L+ GE  F ++   
Sbjct: 351 MILENAVPGTLIALIKIHDQD---------SGE------NGEVNCQLQ-GEVPFKII-SS 393

Query: 485 PPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHY 544
               + L  +G LDRE    Y + + ATD G PPLS+  +++L + D+ND  P+F Q  Y
Sbjct: 394 SKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASY 453

Query: 545 KASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGP 604
             SV E   PG  +  V ASD D             + L+   +   + S +   A    
Sbjct: 454 LVSVPENNPPGASIAQVCASDLD-------------LGLNGQVSYSIMASDLEPLA-LAS 499

Query: 605 SFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
             ++ ++SG +   R  D E     EL + A+D G P LSA   + + V D NDN P
Sbjct: 500 YVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 556



 Score =  147 bits (372), Expect = 3e-35
 Identities = 141/475 (29%), Positives = 198/475 (41%), Gaps = 75/475 (15%)

Query: 71  LSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARR 130
           +S+ E +PP T V  + A      Q EG    ++     +  +  F ++  +G I T ++
Sbjct: 249 VSLRENVPPGTTVLQVSA----TDQDEGINSEITYSFYRTGQI--FSLNSKSGEITTQKK 302

Query: 131 LDRERRDHYSFVAATLLG----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAF 186
           LD E    YS V     G    A   VEI + D ND+SP     SL   + E + PGT  
Sbjct: 303 LDFEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLI 362

Query: 187 RLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL 246
            L   HD D+G                        ++  +  G +P  ++  S +  +  
Sbjct: 363 ALIKIHDQDSGENG---------------------EVNCQLQGEVPFKIISSSKNSYK-- 399

Query: 247 DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306
            LV    LDRE+   + + I A D G+P  +  +SV L + D NDN PVF Q  Y  +V 
Sbjct: 400 -LVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVP 458

Query: 307 EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
           E+  PGA + +V A+D DLG NG V YS+ A  +         L  A+Y ++   SGVV 
Sbjct: 459 ENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLE-------PLALASYVSMSAQSGVVF 511

Query: 367 VWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVA-- 424
             R  D E     +L ++ARD G+    A V + + V D NDN P +    L   G A  
Sbjct: 512 AQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALF 571

Query: 425 -RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPG 483
             V   A PG  V +V   DAD                        S       + +L  
Sbjct: 572 DMVPRAAEPGYLVTKVVAVDAD------------------------SGHNAWLSYHVLQA 607

Query: 484 GPPGVFFLCVEGPLDRESRDL-------YELLLVATDAGSPPLSTEETLLLRVAD 531
             PG+F L +     R +R L         LL+   D G PPLS   TL L  AD
Sbjct: 608 SEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFAD 662



 Score =  145 bits (367), Expect = 1e-34
 Identities = 149/560 (26%), Positives = 226/560 (40%), Gaps = 111/560 (19%)

Query: 119 HPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSL 172
           +P+  + +T   LDRE++ ++  V   L      L    ++ I+V D ND+ P F  D  
Sbjct: 191 YPELALEKT---LDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVY 247

Query: 173 QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
           ++ + E  PPGT      A D D G+ S   Y+  +         G  F L  ++     
Sbjct: 248 RVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYR--------TGQIFSLNSKSG---- 295

Query: 233 SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS---VELRVLDE 289
                         ++   ++LD EE   + + +E  DGG     GL++   VE+ + DE
Sbjct: 296 --------------EITTQKKLDFEETKEYSMVVEGRDGG-----GLVAQCTVEINIQDE 336

Query: 290 NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
           NDN P          + E+A PG  +  ++  D+D G NG V   ++             
Sbjct: 337 NDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQ------------- 383

Query: 350 LGDAAYFAVEELSGVVRVWRP--LDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVN 407
            G+  +  +       ++     LDRE    + + + A D G  P  +++ V + + DVN
Sbjct: 384 -GEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVN 442

Query: 408 DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI 467
           DN P  H        +  V E   PG  +A+V  SD D              +GL +G +
Sbjct: 443 DNAPVFH----QASYLVSVPENNPPGASIAQVCASDLD--------------LGL-NGQV 483

Query: 468 SLSLEGGEGDFALLPG-----GPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
           S S+   + +   L          GV F   +   D E    +EL L A D GSP LS  
Sbjct: 484 SYSIMASDLEPLALASYVSMSAQSGVVF--AQRAFDYEQLRTFELTLQARDQGSPALSAN 541

Query: 523 ETLLLRVADLNDQPP--LFSQQHYKAS-----VSEAAAPGTVVMWVSASDADEAGSDHAW 575
            +L + V D ND  P  L+       S     V  AA PG +V  V A DAD     +AW
Sbjct: 542 VSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSG--HNAW 599

Query: 576 LRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVA 635
           L Y V+Q S P                   F++   +G + T R L         L V  
Sbjct: 600 LSYHVLQASEP-----------------GLFSLGLRTGEVRTARALGDRDAARQRLLVAV 642

Query: 636 QDLGEPPLSATCLVSITVDD 655
           +D G+PPLSAT  + +   D
Sbjct: 643 RDGGQPPLSATATLHLVFAD 662



 Score =  127 bits (319), Expect = 4e-29
 Identities = 120/460 (26%), Positives = 191/460 (41%), Gaps = 83/460 (18%)

Query: 247 DLVLLRRLDREEAAAHR----LQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYR 302
           +L++  RLDREE    +    L+ EA             V + + D ND+ P F Q+ + 
Sbjct: 83  ELLVSSRLDREEICGKKPACALEFEAV---AENPLNFYHVNVEIEDINDHTPKFTQNSFE 139

Query: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
             + E AQPG       A D D+G N   +Y +             +L  +    ++E  
Sbjct: 140 LQISESAQPGTRFILEVAEDADIGLNSLQKYKL-------------SLNPSFSLIIKEKQ 186

Query: 363 G-----VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417
                  + + + LDRE Q++H+LV+ A DGG  P   T  + I V D NDN P  +   
Sbjct: 187 DGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFN--- 243

Query: 418 LTEGGVARVS--EGARPGDYVARVSVSDADGDWEKEDE----ATGELGVGLGDGSISLSL 471
                V RVS  E   PG  V +VS +D D     E       TG++         SL+ 
Sbjct: 244 ---RDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI--------FSLNS 292

Query: 472 EGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVAD 531
           + GE               +  +  LD E    Y +++   D G   L  + T+ + + D
Sbjct: 293 KSGE---------------ITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQD 335

Query: 532 LNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL-G 590
            ND  P  +       + E A PGT++  +   D D   +               C L G
Sbjct: 336 ENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEV-----------NCQLQG 384

Query: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVS 650
            +  K++ +++          S  + T  TLDRE      + + A D G+PPLS++  V 
Sbjct: 385 EVPFKIISSSK---------NSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVI 435

Query: 651 ITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISAQV 690
           + + DVNDN P+F +  Y  ++ E+ P G    Q+ ++ +
Sbjct: 436 LHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDL 475


>gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precursor
           [Homo sapiens]
          Length = 923

 Score =  240 bits (613), Expect = 3e-63
 Identities = 188/597 (31%), Positives = 275/597 (46%), Gaps = 85/597 (14%)

Query: 73  VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
           + E +P  ++VG++   L  + Q+  +       S + P    F V  ++G +  + RLD
Sbjct: 37  IPEEMPKGSVVGNLATDLGFSVQELPTRKL--RVSSEKPY---FTVSAESGELLVSSRLD 91

Query: 133 RERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTA 185
           RE         A    AV +       V + + D+NDH+P+F  +S +L +SE + PGT 
Sbjct: 92  REEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTR 151

Query: 186 FRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEP 245
           F L VA D D GL S Q Y L            P F L  +           GS  P   
Sbjct: 152 FILEVAEDADIGLNSLQKYKL---------SLNPSFSLIIKEKQD-------GSKYP--- 192

Query: 246 LDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAV 305
            +L L + LDRE+ + HRL + A DGG P  +G   + ++V D NDNPPVF +D YR ++
Sbjct: 193 -ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSL 251

Query: 306 REDAQPGAEVCRVRATDRDLGPNGFVRYS-VRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           RE+  PG  V +V ATD+D G N  + YS  R  Q+               F++   SG 
Sbjct: 252 RENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI---------------FSLNSKSGE 296

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVA 424
           +   + LD E    + +VVE RDGG    VA   V I + D NDN P +    L E    
Sbjct: 297 ITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQDENDNSPEVTFHSLLE---- 350

Query: 425 RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGG 484
            + E A PG  +A + + D D         +GE      +G ++  L+ GE  F ++   
Sbjct: 351 MILENAVPGTLIALIKIHDQD---------SGE------NGEVNCQLQ-GEVPFKII-SS 393

Query: 485 PPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHY 544
               + L  +G LDRE    Y + + ATD G PPLS+  +++L + D+ND  P+F Q  Y
Sbjct: 394 SKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASY 453

Query: 545 KASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGP 604
             SV E   PG  +  V ASD D             + L+   +   + S +   A    
Sbjct: 454 LVSVPENNPPGASIAQVCASDLD-------------LGLNGQVSYSIMASDLEPLA-LAS 499

Query: 605 SFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
             ++ ++SG +   R  D E     EL + A+D G P LSA   + + V D NDN P
Sbjct: 500 YVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 556



 Score =  147 bits (372), Expect = 3e-35
 Identities = 141/475 (29%), Positives = 198/475 (41%), Gaps = 75/475 (15%)

Query: 71  LSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARR 130
           +S+ E +PP T V  + A      Q EG    ++     +  +  F ++  +G I T ++
Sbjct: 249 VSLRENVPPGTTVLQVSA----TDQDEGINSEITYSFYRTGQI--FSLNSKSGEITTQKK 302

Query: 131 LDRERRDHYSFVAATLLG----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAF 186
           LD E    YS V     G    A   VEI + D ND+SP     SL   + E + PGT  
Sbjct: 303 LDFEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLI 362

Query: 187 RLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL 246
            L   HD D+G                        ++  +  G +P  ++  S +  +  
Sbjct: 363 ALIKIHDQDSGENG---------------------EVNCQLQGEVPFKIISSSKNSYK-- 399

Query: 247 DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306
            LV    LDRE+   + + I A D G+P  +  +SV L + D NDN PVF Q  Y  +V 
Sbjct: 400 -LVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVP 458

Query: 307 EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
           E+  PGA + +V A+D DLG NG V YS+ A  +         L  A+Y ++   SGVV 
Sbjct: 459 ENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLE-------PLALASYVSMSAQSGVVF 511

Query: 367 VWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVA-- 424
             R  D E     +L ++ARD G+    A V + + V D NDN P +    L   G A  
Sbjct: 512 AQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALF 571

Query: 425 -RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPG 483
             V   A PG  V +V   DAD                        S       + +L  
Sbjct: 572 DMVPRAAEPGYLVTKVVAVDAD------------------------SGHNAWLSYHVLQA 607

Query: 484 GPPGVFFLCVEGPLDRESRDL-------YELLLVATDAGSPPLSTEETLLLRVAD 531
             PG+F L +     R +R L         LL+   D G PPLS   TL L  AD
Sbjct: 608 SEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFAD 662



 Score =  145 bits (367), Expect = 1e-34
 Identities = 149/560 (26%), Positives = 226/560 (40%), Gaps = 111/560 (19%)

Query: 119 HPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSL 172
           +P+  + +T   LDRE++ ++  V   L      L    ++ I+V D ND+ P F  D  
Sbjct: 191 YPELALEKT---LDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVY 247

Query: 173 QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP 232
           ++ + E  PPGT      A D D G+ S   Y+  +         G  F L  ++     
Sbjct: 248 RVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYR--------TGQIFSLNSKSG---- 295

Query: 233 SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS---VELRVLDE 289
                         ++   ++LD EE   + + +E  DGG     GL++   VE+ + DE
Sbjct: 296 --------------EITTQKKLDFEETKEYSMVVEGRDGG-----GLVAQCTVEINIQDE 336

Query: 290 NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
           NDN P          + E+A PG  +  ++  D+D G NG V   ++             
Sbjct: 337 NDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQ------------- 383

Query: 350 LGDAAYFAVEELSGVVRVWRP--LDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVN 407
            G+  +  +       ++     LDRE    + + + A D G  P  +++ V + + DVN
Sbjct: 384 -GEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVN 442

Query: 408 DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI 467
           DN P  H        +  V E   PG  +A+V  SD D              +GL +G +
Sbjct: 443 DNAPVFH----QASYLVSVPENNPPGASIAQVCASDLD--------------LGL-NGQV 483

Query: 468 SLSLEGGEGDFALLPG-----GPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
           S S+   + +   L          GV F   +   D E    +EL L A D GSP LS  
Sbjct: 484 SYSIMASDLEPLALASYVSMSAQSGVVF--AQRAFDYEQLRTFELTLQARDQGSPALSAN 541

Query: 523 ETLLLRVADLNDQPP--LFSQQHYKAS-----VSEAAAPGTVVMWVSASDADEAGSDHAW 575
            +L + V D ND  P  L+       S     V  AA PG +V  V A DAD     +AW
Sbjct: 542 VSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSG--HNAW 599

Query: 576 LRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVA 635
           L Y V+Q S P                   F++   +G + T R L         L V  
Sbjct: 600 LSYHVLQASEP-----------------GLFSLGLRTGEVRTARALGDRDAARQRLLVAV 642

Query: 636 QDLGEPPLSATCLVSITVDD 655
           +D G+PPLSAT  + +   D
Sbjct: 643 RDGGQPPLSATATLHLVFAD 662



 Score =  127 bits (319), Expect = 4e-29
 Identities = 120/460 (26%), Positives = 191/460 (41%), Gaps = 83/460 (18%)

Query: 247 DLVLLRRLDREEAAAHR----LQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYR 302
           +L++  RLDREE    +    L+ EA             V + + D ND+ P F Q+ + 
Sbjct: 83  ELLVSSRLDREEICGKKPACALEFEAV---AENPLNFYHVNVEIEDINDHTPKFTQNSFE 139

Query: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
             + E AQPG       A D D+G N   +Y +             +L  +    ++E  
Sbjct: 140 LQISESAQPGTRFILEVAEDADIGLNSLQKYKL-------------SLNPSFSLIIKEKQ 186

Query: 363 G-----VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417
                  + + + LDRE Q++H+LV+ A DGG  P   T  + I V D NDN P  +   
Sbjct: 187 DGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFN--- 243

Query: 418 LTEGGVARVS--EGARPGDYVARVSVSDADGDWEKEDE----ATGELGVGLGDGSISLSL 471
                V RVS  E   PG  V +VS +D D     E       TG++         SL+ 
Sbjct: 244 ---RDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI--------FSLNS 292

Query: 472 EGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVAD 531
           + GE               +  +  LD E    Y +++   D G   L  + T+ + + D
Sbjct: 293 KSGE---------------ITTQKKLDFEETKEYSMVVEGRDGGG--LVAQCTVEINIQD 335

Query: 532 LNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL-G 590
            ND  P  +       + E A PGT++  +   D D   +               C L G
Sbjct: 336 ENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEV-----------NCQLQG 384

Query: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVS 650
            +  K++ +++          S  + T  TLDRE      + + A D G+PPLS++  V 
Sbjct: 385 EVPFKIISSSK---------NSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVI 435

Query: 651 ITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISAQV 690
           + + DVNDN P+F +  Y  ++ E+ P G    Q+ ++ +
Sbjct: 436 LHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDL 475


>gi|14589880 protocadherin gamma subfamily A, 3 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  239 bits (611), Expect = 5e-63
 Identities = 190/627 (30%), Positives = 291/627 (46%), Gaps = 81/627 (12%)

Query: 42  RTQRSLLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGF 101
           R  R L  L   +     +GS    ++++  +D+G     +  D+  GL   +  E    
Sbjct: 8   RNGRGLALLCALLGTLCETGSGQIRYSVSEELDKGSFVGNIANDL--GLEPRELAERGVR 65

Query: 102 FLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VE 154
            +S           F ++P +G + TA R+DRE       +    +  +V+       VE
Sbjct: 66  IVSRGRTQL-----FSLNPQSGSLVTAERIDREELCAQIPLCLVKINILVEDKLKIFEVE 120

Query: 155 IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214
           I + D+ND++P FP + L++ + EL+ PGT F +  A DPD G+ S Q Y L  P+D   
Sbjct: 121 IEIKDINDNAPNFPTEELEIKIGELTVPGTRFPIKTAFDPDVGINSLQNYKL-SPND--- 176

Query: 215 DPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP 274
                +F L   +       +  G+  P    +LVL R LDRE+   H+L + A DGG P
Sbjct: 177 -----YFSLAVNS-------VSEGAKYP----ELVLERALDREKKEIHQLVLVASDGGDP 220

Query: 275 RRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYS 334
             +G L +++ VLD NDNPP+F Q EYR +V E+   G  +  V ATD D G N  V Y 
Sbjct: 221 VHSGNLHIQVIVLDANDNPPMFTQPEYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYI 280

Query: 335 VRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV 394
           +   ++PG          A  F +  +SG V + + LD E   ++++ +EA+DG     +
Sbjct: 281 L--DKMPGK--------IAEIFHLNSVSGEVSILKSLDYEDAMFYEIKIEAQDGPG--LL 328

Query: 395 ATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEA 454
           +  ++ + VLDVNDN P I +  LT    + V E    G  +A + V D D     + E 
Sbjct: 329 SRAKILVTVLDVNDNAPEITITSLT----SSVPEEGTVGREIALIDVHDRDSGQNGQVEV 384

Query: 455 TGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDA 514
                     G++   LE     +          + L     LDRE    Y + L A+D 
Sbjct: 385 -------FVLGNLPFKLEKSIDQY----------YRLVTATSLDREQISEYNISLRASDG 427

Query: 515 GSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
           GSPPLSTE  + L V D+ND PP F    Y A + E    G  +  V+A D D   +++A
Sbjct: 428 GSPPLSTETHITLHVIDINDNPPTFPHLSYSAYIPENNPRGASIFSVTAQDPD--SNNNA 485

Query: 575 WLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV 634
            + Y            +L    +  A      +I+S +G +  +R+ D E    ++L V 
Sbjct: 486 RITY------------ALTEDTLQGAPLSSFVSINSNTGVLYALRSFDYEQFRDLKLLVT 533

Query: 635 AQDLGEPPLSATCLVSITVDDVNDNEP 661
           A D G PPLS+   +++ V D NDN P
Sbjct: 534 ASDSGNPPLSSNVSLNLFVLDQNDNAP 560



 Score =  132 bits (333), Expect = 8e-31
 Identities = 149/545 (27%), Positives = 229/545 (42%), Gaps = 94/545 (17%)

Query: 129 RRLDRERRDHYSFVAATLLGAV------VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           R LDRE+++ +  V     G        + +++ V D ND+ P F     ++ V E  P 
Sbjct: 198 RALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLDANDNPPMFTQPEYRVSVWENVPV 257

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           GT      A DPD G  +   Y L                   + PG +       S S 
Sbjct: 258 GTRLLTVNATDPDEGFNAQVSYILD------------------KMPGKIAEIFHLNSVSG 299

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS---VELRVLDENDNPPVFEQD 299
               ++ +L+ LD E+A  + ++IEA DG      GLLS   + + VLD NDN P     
Sbjct: 300 ----EVSILKSLDYEDAMFYEIKIEAQDG-----PGLLSRAKILVTVLDVNDNAPEITIT 350

Query: 300 EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVE 359
              ++V E+   G E+  +   DRD G NG V   V              LG+  +   +
Sbjct: 351 SLTSSVPEEGTVGREIALIDVHDRDSGQNGQVEVFV--------------LGNLPFKLEK 396

Query: 360 ELSGVVRVWRP--LDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417
            +    R+     LDRE  + + + + A DGG+ P      +++ V+D+NDN P    L 
Sbjct: 397 SIDQYYRLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDINDNPPTFPHLS 456

Query: 418 LTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGD 477
            +    A + E    G  +  V+  D D +          +   L + +    L+G    
Sbjct: 457 YS----AYIPENNPRGASIFSVTAQDPDSN------NNARITYALTEDT----LQGAPLS 502

Query: 478 FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
             +      GV +       + + RDL +LL+ A+D+G+PPLS+  +L L V D ND  P
Sbjct: 503 SFVSINSNTGVLYALRSFDYE-QFRDL-KLLVTASDSGNPPLSSNVSLNLFVLDQNDNAP 560

Query: 538 --LFSQQHYKASVS-----EAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
             L+       S        +A PG +V  V A D D     +AWL Y +++ S P    
Sbjct: 561 EILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG--QNAWLSYRLLKASEP---- 614

Query: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVS 650
            L S  +HT E   + A+            LDR+  +   L V  QD G+PPLSAT  ++
Sbjct: 615 GLFSVGLHTGEVRTARAL------------LDRDALKQ-SLVVAVQDHGQPPLSATVTLT 661

Query: 651 ITVDD 655
           + V D
Sbjct: 662 VAVAD 666



 Score =  117 bits (292), Expect = 5e-26
 Identities = 127/477 (26%), Positives = 190/477 (39%), Gaps = 75/477 (15%)

Query: 71  LSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSP--LLDDFHVHPDTGIIRTA 128
           +SV E +P  T +  + A  P     EG    +S   D  P  + + FH++  +G +   
Sbjct: 249 VSVWENVPVGTRLLTVNATDP----DEGFNAQVSYILDKMPGKIAEIFHLNSVSGEVSIL 304

Query: 129 RRLDRERRDHYSFVAATLLG----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           + LD E    Y        G    +  ++ + V DVND++P   + SL   V E    G 
Sbjct: 305 KSLDYEDAMFYEIKIEAQDGPGLLSRAKILVTVLDVNDNAPEITITSLTSSVPEEGTVGR 364

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
              L   HD D+G                        Q+     G LP  L     S  +
Sbjct: 365 EIALIDVHDRDSGQNG---------------------QVEVFVLGNLPFKL---EKSIDQ 400

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
              LV    LDRE+ + + + + A DGG P  +    + L V+D NDNPP F    Y A 
Sbjct: 401 YYRLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDINDNPPTFPHLSYSAY 460

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           + E+   GA +  V A D D   N  + Y++    + GA         +++ ++   +GV
Sbjct: 461 IPENNPRGASIFSVTAQDPDSNNNARITYALTEDTLQGAPL-------SSFVSINSNTGV 513

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLTEG-- 421
           +   R  D E     +L+V A D G  P  + V +++ VLD NDN P I +    T+G  
Sbjct: 514 LYALRSFDYEQFRDLKLLVTASDSGNPPLSSNVSLNLFVLDQNDNAPEILYPALPTDGST 573

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
           GV      A PG  V +V   D D                        S +     + LL
Sbjct: 574 GVELAPRSAEPGYLVTKVVAVDRD------------------------SGQNAWLSYRLL 609

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYE-------LLLVATDAGSPPLSTEETLLLRVAD 531
               PG+F + +     R +R L +       L++   D G PPLS   TL + VAD
Sbjct: 610 KASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 666



 Score =  107 bits (267), Expect = 4e-23
 Identities = 114/443 (25%), Positives = 171/443 (38%), Gaps = 69/443 (15%)

Query: 248 LVLLRRLDREEAAAH------RLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
           LV   R+DREE  A       ++ I   D     +  +  VE+ + D NDN P F  +E 
Sbjct: 84  LVTAERIDREELCAQIPLCLVKINILVED-----KLKIFEVEIEIKDINDNAPNFPTEEL 138

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
              + E   PG       A D D+G N    Y +             + G      V E 
Sbjct: 139 EIKIGELTVPGTRFPIKTAFDPDVGINSLQNYKLSPNDYFSLAVNSVSEGAKYPELVLE- 197

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
                  R LDRE +  HQLV+ A DGG       + + + VLD NDN P    +F    
Sbjct: 198 -------RALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLDANDNPP----MFTQPE 246

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKE-----DEATGELGVGLGDGSISLSLEGGEG 476
               V E    G  +  V+ +D D  +  +     D+  G++       S+S       G
Sbjct: 247 YRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMPGKIAEIFHLNSVS-------G 299

Query: 477 DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
           + ++L               LD E    YE+ + A D   P L +   +L+ V D+ND  
Sbjct: 300 EVSILKS-------------LDYEDAMFYEIKIEAQDG--PGLLSRAKILVTVLDVNDNA 344

Query: 537 PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
           P  +     +SV E    G  +  +   D D   +    +            LG+L  K+
Sbjct: 345 PEITITSLTSSVPEEGTVGREIALIDVHDRDSGQNGQVEVFV----------LGNLPFKL 394

Query: 597 VHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDV 656
             + +         +   + T  +LDRE      + + A D G PPLS    +++ V D+
Sbjct: 395 EKSID---------QYYRLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDI 445

Query: 657 NDNEPIFWRQVYNATIAEHAPVG 679
           NDN P F    Y+A I E+ P G
Sbjct: 446 NDNPPTFPHLSYSAYIPENNPRG 468



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 49/182 (26%), Positives = 79/182 (43%), Gaps = 23/182 (12%)

Query: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
           + + D+ND  P F  +  +  + E   PGT     +A D D     ++   Y +    +P
Sbjct: 121 IEIKDINDNAPNFPTEELEIKIGELTVPGTRFPIKTAFDPDVG--INSLQNYKL----SP 174

Query: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646
            +  SL    V      P   ++         R LDRE +E  +L +VA D G+P  S  
Sbjct: 175 NDYFSLAVNSVSEGAKYPELVLE---------RALDREKKEIHQLVLVASDGGDPVHSGN 225

Query: 647 CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL--------ISAQVAFVKIKQK 698
             + + V D NDN P+F +  Y  ++ E+ PVG   L +         +AQV+++  K  
Sbjct: 226 LHIQVIVLDANDNPPMFTQPEYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMP 285

Query: 699 QK 700
            K
Sbjct: 286 GK 287


>gi|14196465 protocadherin gamma subfamily A, 3 isoform 2 precursor
           [Homo sapiens]
          Length = 829

 Score =  239 bits (611), Expect = 5e-63
 Identities = 190/627 (30%), Positives = 291/627 (46%), Gaps = 81/627 (12%)

Query: 42  RTQRSLLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGF 101
           R  R L  L   +     +GS    ++++  +D+G     +  D+  GL   +  E    
Sbjct: 8   RNGRGLALLCALLGTLCETGSGQIRYSVSEELDKGSFVGNIANDL--GLEPRELAERGVR 65

Query: 102 FLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VE 154
            +S           F ++P +G + TA R+DRE       +    +  +V+       VE
Sbjct: 66  IVSRGRTQL-----FSLNPQSGSLVTAERIDREELCAQIPLCLVKINILVEDKLKIFEVE 120

Query: 155 IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214
           I + D+ND++P FP + L++ + EL+ PGT F +  A DPD G+ S Q Y L  P+D   
Sbjct: 121 IEIKDINDNAPNFPTEELEIKIGELTVPGTRFPIKTAFDPDVGINSLQNYKL-SPND--- 176

Query: 215 DPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP 274
                +F L   +       +  G+  P    +LVL R LDRE+   H+L + A DGG P
Sbjct: 177 -----YFSLAVNS-------VSEGAKYP----ELVLERALDREKKEIHQLVLVASDGGDP 220

Query: 275 RRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYS 334
             +G L +++ VLD NDNPP+F Q EYR +V E+   G  +  V ATD D G N  V Y 
Sbjct: 221 VHSGNLHIQVIVLDANDNPPMFTQPEYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYI 280

Query: 335 VRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV 394
           +   ++PG          A  F +  +SG V + + LD E   ++++ +EA+DG     +
Sbjct: 281 L--DKMPGK--------IAEIFHLNSVSGEVSILKSLDYEDAMFYEIKIEAQDGPG--LL 328

Query: 395 ATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEA 454
           +  ++ + VLDVNDN P I +  LT    + V E    G  +A + V D D     + E 
Sbjct: 329 SRAKILVTVLDVNDNAPEITITSLT----SSVPEEGTVGREIALIDVHDRDSGQNGQVEV 384

Query: 455 TGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDA 514
                     G++   LE     +          + L     LDRE    Y + L A+D 
Sbjct: 385 -------FVLGNLPFKLEKSIDQY----------YRLVTATSLDREQISEYNISLRASDG 427

Query: 515 GSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
           GSPPLSTE  + L V D+ND PP F    Y A + E    G  +  V+A D D   +++A
Sbjct: 428 GSPPLSTETHITLHVIDINDNPPTFPHLSYSAYIPENNPRGASIFSVTAQDPD--SNNNA 485

Query: 575 WLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVV 634
            + Y            +L    +  A      +I+S +G +  +R+ D E    ++L V 
Sbjct: 486 RITY------------ALTEDTLQGAPLSSFVSINSNTGVLYALRSFDYEQFRDLKLLVT 533

Query: 635 AQDLGEPPLSATCLVSITVDDVNDNEP 661
           A D G PPLS+   +++ V D NDN P
Sbjct: 534 ASDSGNPPLSSNVSLNLFVLDQNDNAP 560



 Score =  132 bits (333), Expect = 8e-31
 Identities = 149/545 (27%), Positives = 229/545 (42%), Gaps = 94/545 (17%)

Query: 129 RRLDRERRDHYSFVAATLLGAV------VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           R LDRE+++ +  V     G        + +++ V D ND+ P F     ++ V E  P 
Sbjct: 198 RALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLDANDNPPMFTQPEYRVSVWENVPV 257

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           GT      A DPD G  +   Y L                   + PG +       S S 
Sbjct: 258 GTRLLTVNATDPDEGFNAQVSYILD------------------KMPGKIAEIFHLNSVSG 299

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS---VELRVLDENDNPPVFEQD 299
               ++ +L+ LD E+A  + ++IEA DG      GLLS   + + VLD NDN P     
Sbjct: 300 ----EVSILKSLDYEDAMFYEIKIEAQDG-----PGLLSRAKILVTVLDVNDNAPEITIT 350

Query: 300 EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVE 359
              ++V E+   G E+  +   DRD G NG V   V              LG+  +   +
Sbjct: 351 SLTSSVPEEGTVGREIALIDVHDRDSGQNGQVEVFV--------------LGNLPFKLEK 396

Query: 360 ELSGVVRVWRP--LDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417
            +    R+     LDRE  + + + + A DGG+ P      +++ V+D+NDN P    L 
Sbjct: 397 SIDQYYRLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDINDNPPTFPHLS 456

Query: 418 LTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGD 477
            +    A + E    G  +  V+  D D +          +   L + +    L+G    
Sbjct: 457 YS----AYIPENNPRGASIFSVTAQDPDSN------NNARITYALTEDT----LQGAPLS 502

Query: 478 FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
             +      GV +       + + RDL +LL+ A+D+G+PPLS+  +L L V D ND  P
Sbjct: 503 SFVSINSNTGVLYALRSFDYE-QFRDL-KLLVTASDSGNPPLSSNVSLNLFVLDQNDNAP 560

Query: 538 --LFSQQHYKASVS-----EAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
             L+       S        +A PG +V  V A D D     +AWL Y +++ S P    
Sbjct: 561 EILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG--QNAWLSYRLLKASEP---- 614

Query: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVS 650
            L S  +HT E   + A+            LDR+  +   L V  QD G+PPLSAT  ++
Sbjct: 615 GLFSVGLHTGEVRTARAL------------LDRDALKQ-SLVVAVQDHGQPPLSATVTLT 661

Query: 651 ITVDD 655
           + V D
Sbjct: 662 VAVAD 666



 Score =  117 bits (292), Expect = 5e-26
 Identities = 127/477 (26%), Positives = 190/477 (39%), Gaps = 75/477 (15%)

Query: 71  LSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSP--LLDDFHVHPDTGIIRTA 128
           +SV E +P  T +  + A  P     EG    +S   D  P  + + FH++  +G +   
Sbjct: 249 VSVWENVPVGTRLLTVNATDP----DEGFNAQVSYILDKMPGKIAEIFHLNSVSGEVSIL 304

Query: 129 RRLDRERRDHYSFVAATLLG----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           + LD E    Y        G    +  ++ + V DVND++P   + SL   V E    G 
Sbjct: 305 KSLDYEDAMFYEIKIEAQDGPGLLSRAKILVTVLDVNDNAPEITITSLTSSVPEEGTVGR 364

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
              L   HD D+G                        Q+     G LP  L     S  +
Sbjct: 365 EIALIDVHDRDSGQNG---------------------QVEVFVLGNLPFKL---EKSIDQ 400

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
              LV    LDRE+ + + + + A DGG P  +    + L V+D NDNPP F    Y A 
Sbjct: 401 YYRLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDINDNPPTFPHLSYSAY 460

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGV 364
           + E+   GA +  V A D D   N  + Y++    + GA         +++ ++   +GV
Sbjct: 461 IPENNPRGASIFSVTAQDPDSNNNARITYALTEDTLQGAPL-------SSFVSINSNTGV 513

Query: 365 VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLTEG-- 421
           +   R  D E     +L+V A D G  P  + V +++ VLD NDN P I +    T+G  
Sbjct: 514 LYALRSFDYEQFRDLKLLVTASDSGNPPLSSNVSLNLFVLDQNDNAPEILYPALPTDGST 573

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
           GV      A PG  V +V   D D                        S +     + LL
Sbjct: 574 GVELAPRSAEPGYLVTKVVAVDRD------------------------SGQNAWLSYRLL 609

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYE-------LLLVATDAGSPPLSTEETLLLRVAD 531
               PG+F + +     R +R L +       L++   D G PPLS   TL + VAD
Sbjct: 610 KASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 666



 Score =  107 bits (267), Expect = 4e-23
 Identities = 114/443 (25%), Positives = 171/443 (38%), Gaps = 69/443 (15%)

Query: 248 LVLLRRLDREEAAAH------RLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
           LV   R+DREE  A       ++ I   D     +  +  VE+ + D NDN P F  +E 
Sbjct: 84  LVTAERIDREELCAQIPLCLVKINILVED-----KLKIFEVEIEIKDINDNAPNFPTEEL 138

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
              + E   PG       A D D+G N    Y +             + G      V E 
Sbjct: 139 EIKIGELTVPGTRFPIKTAFDPDVGINSLQNYKLSPNDYFSLAVNSVSEGAKYPELVLE- 197

Query: 362 SGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
                  R LDRE +  HQLV+ A DGG       + + + VLD NDN P    +F    
Sbjct: 198 -------RALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLDANDNPP----MFTQPE 246

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKE-----DEATGELGVGLGDGSISLSLEGGEG 476
               V E    G  +  V+ +D D  +  +     D+  G++       S+S       G
Sbjct: 247 YRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMPGKIAEIFHLNSVS-------G 299

Query: 477 DFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQP 536
           + ++L               LD E    YE+ + A D   P L +   +L+ V D+ND  
Sbjct: 300 EVSILKS-------------LDYEDAMFYEIKIEAQDG--PGLLSRAKILVTVLDVNDNA 344

Query: 537 PLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKM 596
           P  +     +SV E    G  +  +   D D   +    +            LG+L  K+
Sbjct: 345 PEITITSLTSSVPEEGTVGREIALIDVHDRDSGQNGQVEVFV----------LGNLPFKL 394

Query: 597 VHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDV 656
             + +         +   + T  +LDRE      + + A D G PPLS    +++ V D+
Sbjct: 395 EKSID---------QYYRLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDI 445

Query: 657 NDNEPIFWRQVYNATIAEHAPVG 679
           NDN P F    Y+A I E+ P G
Sbjct: 446 NDNPPTFPHLSYSAYIPENNPRG 468



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 49/182 (26%), Positives = 79/182 (43%), Gaps = 23/182 (12%)

Query: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
           + + D+ND  P F  +  +  + E   PGT     +A D D     ++   Y +    +P
Sbjct: 121 IEIKDINDNAPNFPTEELEIKIGELTVPGTRFPIKTAFDPDVG--INSLQNYKL----SP 174

Query: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646
            +  SL    V      P   ++         R LDRE +E  +L +VA D G+P  S  
Sbjct: 175 NDYFSLAVNSVSEGAKYPELVLE---------RALDREKKEIHQLVLVASDGGDPVHSGN 225

Query: 647 CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL--------ISAQVAFVKIKQK 698
             + + V D NDN P+F +  Y  ++ E+ PVG   L +         +AQV+++  K  
Sbjct: 226 LHIQVIVLDANDNPPMFTQPEYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMP 285

Query: 699 QK 700
            K
Sbjct: 286 GK 287


>gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precursor
           [Homo sapiens]
          Length = 837

 Score =  239 bits (610), Expect = 6e-63
 Identities = 200/628 (31%), Positives = 290/628 (46%), Gaps = 81/628 (12%)

Query: 42  RTQRSLLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGF 101
           R  RS L LL+ ++L    G  A+   +  SV E     + VG+I   L    ++     
Sbjct: 7   RGDRSRLLLLLCIFLGTLRGFRAR--QIRYSVPEETEKGSFVGNISKDLGLEPRELAKRG 64

Query: 102 FLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHY---SFVAATLLGA----VVQVE 154
                   + L   F V+P +G + TA R+DRE         F+   LL      +  VE
Sbjct: 65  VRIVSRGKTQL---FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVE 121

Query: 155 IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214
           + + D+ND++P F  D +++ VSE + PG  F LP A DPD G+ S Q Y L        
Sbjct: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-------- 173

Query: 215 DPAGPF-FQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGR 273
            P   F  QLR RT G         + +P    +LVL   LDRE+ AAH L + A DGG 
Sbjct: 174 SPNNYFSLQLRGRTDG---------AKNP----ELVLEGSLDREKEAAHLLLLTALDGGD 220

Query: 274 PRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRY 333
           P R G + + + VLD ND+ P+F Q  YR +V E+   G  V  V ATD D G NG V Y
Sbjct: 221 PIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMY 280

Query: 334 SVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE 393
           S R  +             +  F ++  +G V+V   LD E   ++++ ++ +DGG    
Sbjct: 281 SFRNMESKA----------SEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--L 328

Query: 394 VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453
             T  + I V+DVNDN P I +       +  + E + PG  +A ++V D D        
Sbjct: 329 FTTTTMLITVVDVNDNAPEITI----TSSINSILENSPPGTVIALLNVQDQDSG------ 378

Query: 454 ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
             G++   +    +   LE   G++          + L     LDRE    Y + L ATD
Sbjct: 379 ENGQVSCFI-PNHLPFKLEKTYGNY----------YKLITSRVLDRELVQSYNITLTATD 427

Query: 514 AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDH 573
            GSPPLS E  + L VAD ND PP+F    Y A + E    G  +  V+A D D     +
Sbjct: 428 QGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPD--SKQN 485

Query: 574 AWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKV 633
           A + Y            SL    V         +I+S +G +  +++ D E    +EL+V
Sbjct: 486 ALVTY------------SLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRV 533

Query: 634 VAQDLGEPPLSATCLVSITVDDVNDNEP 661
           +A+D G+PPLS+   +S+ V D NDN P
Sbjct: 534 IARDSGDPPLSSNVSLSLFVLDQNDNAP 561



 Score =  126 bits (316), Expect = 8e-29
 Identities = 117/404 (28%), Positives = 162/404 (40%), Gaps = 54/404 (13%)

Query: 279 LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
           +  VE+ ++D NDN P F++DE    V E A PGA      A D D+G N    Y +   
Sbjct: 117 IYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPN 176

Query: 339 QVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVR 398
                   G   G      V E S        LDRE +A H L++ A DGG       V 
Sbjct: 177 NYFSLQLRGRTDGAKNPELVLEGS--------LDREKEAAHLLLLTALDGGDPIRKGAVP 228

Query: 399 VSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGEL 458
           + + VLDVND+ P    +F        V E    G  V  V+ +D D     E   +   
Sbjct: 229 IRVVVLDVNDHIP----MFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRN 284

Query: 459 GVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPP 518
                     L  + GE               + V G LD E    YE+ +   D G   
Sbjct: 285 MESKASEIFQLDSQTGE---------------VQVRGSLDFEKYRFYEMEIQGQDGGG-- 327

Query: 519 LSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRY 578
           L T  T+L+ V D+ND  P  +      S+ E + PGTV+  ++  D D   +       
Sbjct: 328 LFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQ----- 382

Query: 579 TVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESG---AISTIRTLDREVQEAVELKVVA 635
             V    P +L                F ++   G    + T R LDRE+ ++  + + A
Sbjct: 383 --VSCFIPNHL---------------PFKLEKTYGNYYKLITSRVLDRELVQSYNITLTA 425

Query: 636 QDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVG 679
            D G PPLSA   V + V D NDN P+F    Y+A I E+ P G
Sbjct: 426 TDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRG 469



 Score =  119 bits (298), Expect = 1e-26
 Identities = 126/444 (28%), Positives = 176/444 (39%), Gaps = 83/444 (18%)

Query: 109 DSPLLDDFHVHPDTGIIRTARRLDRERRDHYS-----------FVAATLLGAVVQVEIRV 157
           +S   + F +   TG ++    LD E+   Y            F   T+L  VV      
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVV------ 339

Query: 158 NDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPA 217
            DVND++P   + S    + E SPPGT   L    D D+G       +   P+ LP    
Sbjct: 340 -DVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSG--ENGQVSCFIPNHLP---- 392

Query: 218 GPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRT 277
              F+L  +T G                  L+  R LDRE   ++ + + A D G P  +
Sbjct: 393 ---FKLE-KTYGNY--------------YKLITSRVLDRELVQSYNITLTATDQGSPPLS 434

Query: 278 GLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRA 337
               V L V D+NDNPPVF    Y A + E+   GA +  V A D D   N  V YS+  
Sbjct: 435 AETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTD 494

Query: 338 RQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATV 397
             V G          ++Y ++   +GV+   +  D E     +L V ARD G  P  + V
Sbjct: 495 DTVQGVPL-------SSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNV 547

Query: 398 RVSIAVLDVNDNRPAI-HVLFLTEG--GVARVSEGARPGDYVARVSVSDADGDWEKEDEA 454
            +S+ VLD NDN P I +    T+G  GV      A PG  V +V   D D         
Sbjct: 548 SLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKD--------- 598

Query: 455 TGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYE-------L 507
                          S +     + LL    PG+F +       R +R L +       L
Sbjct: 599 ---------------SGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSL 643

Query: 508 LLVATDAGSPPLSTEETLLLRVAD 531
           ++   D G PPLS   TL + VAD
Sbjct: 644 VVAVQDHGQPPLSATVTLTVAVAD 667



 Score =  113 bits (282), Expect = 7e-25
 Identities = 142/542 (26%), Positives = 216/542 (39%), Gaps = 92/542 (16%)

Query: 131 LDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE+   +  +   L G        V + + V DVNDH P F     ++ V E    GT
Sbjct: 201 LDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGT 260

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
              +  A DPD G+     Y+        +  A   FQL  +T                 
Sbjct: 261 RVLMVNATDPDEGINGEVMYSFRNM----ESKASEIFQLDSQTG---------------- 300

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
             ++ +   LD E+   + ++I+  DGG    T  + +   V+D NDN P         +
Sbjct: 301 --EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLIT--VVDVNDNAPEITITSSINS 356

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSG- 363
           + E++ PG  +  +   D+D G NG V   +    +P              F +E+  G 
Sbjct: 357 ILENSPPGTVIALLNVQDQDSGENGQVSCFI-PNHLP--------------FKLEKTYGN 401

Query: 364 --VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
              +   R LDRE    + + + A D G+ P  A   V + V D NDN P    +F    
Sbjct: 402 YYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP----VFPHSS 457

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
             A + E    G  +  V+  D D       +    +   L D ++    +G      + 
Sbjct: 458 YSAYIPENNPRGASIFSVTALDPDS------KQNALVTYSLTDDTV----QGVPLSSYVS 507

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP--LF 539
                GV +       + + RDL EL ++A D+G PPLS+  +L L V D ND  P  L+
Sbjct: 508 INSNTGVLYALQSFDYE-QFRDL-ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILY 565

Query: 540 SQQHYKASVS-----EAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQS 594
                  S        +A PG +V  V A D D     +AWL Y +++ S P        
Sbjct: 566 PALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG--QNAWLSYRLLKASEP-------- 615

Query: 595 KMVHTAECGPSFAIDSESGAISTIRTL-DREVQEAVELKVVAQDLGEPPLSATCLVSITV 653
                      FA+   +G + T R L DR+  +   L V  QD G+PPLSAT  +++ V
Sbjct: 616 ---------GLFAVGEHTGEVRTARALLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAV 665

Query: 654 DD 655
            D
Sbjct: 666 AD 667



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 56/194 (28%), Positives = 84/194 (43%), Gaps = 24/194 (12%)

Query: 491 LCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLL-----RVADLNDQPPLFSQQHYK 545
           L   G +DRE  +L E   V++   +  L  E+TL +      + D+ND  P F +   +
Sbjct: 85  LITAGRIDRE--ELCET--VSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVE 140

Query: 546 ASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS 605
             VSE A PG      +A D D   +          QLS P N  SLQ +        P 
Sbjct: 141 IKVSEHAIPGARFALPNARDPDVGVNS-----LQSYQLS-PNNYFSLQLRGRTDGAKNPE 194

Query: 606 FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWR 665
             ++          +LDRE + A  L + A D G+P       + + V DVND+ P+F +
Sbjct: 195 LVLEG---------SLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQ 245

Query: 666 QVYNATIAEHAPVG 679
            VY  ++ E+   G
Sbjct: 246 SVYRVSVPENISSG 259



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 23/78 (29%), Positives = 36/78 (46%), Gaps = 1/78 (1%)

Query: 606 FAIDSESGAISTIRTLDRE-VQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFW 664
           FA++  SG++ T   +DRE + E V    +  +L          V + + D+NDN P F 
Sbjct: 76  FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQ 135

Query: 665 RQVYNATIAEHAPVGHCF 682
                  ++EHA  G  F
Sbjct: 136 EDEVEIKVSEHAIPGARF 153


>gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precursor
           [Homo sapiens]
          Length = 935

 Score =  239 bits (610), Expect = 6e-63
 Identities = 200/628 (31%), Positives = 290/628 (46%), Gaps = 81/628 (12%)

Query: 42  RTQRSLLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGF 101
           R  RS L LL+ ++L    G  A+   +  SV E     + VG+I   L    ++     
Sbjct: 7   RGDRSRLLLLLCIFLGTLRGFRAR--QIRYSVPEETEKGSFVGNISKDLGLEPRELAKRG 64

Query: 102 FLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHY---SFVAATLLGA----VVQVE 154
                   + L   F V+P +G + TA R+DRE         F+   LL      +  VE
Sbjct: 65  VRIVSRGKTQL---FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVE 121

Query: 155 IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214
           + + D+ND++P F  D +++ VSE + PG  F LP A DPD G+ S Q Y L        
Sbjct: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-------- 173

Query: 215 DPAGPF-FQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGR 273
            P   F  QLR RT G         + +P    +LVL   LDRE+ AAH L + A DGG 
Sbjct: 174 SPNNYFSLQLRGRTDG---------AKNP----ELVLEGSLDREKEAAHLLLLTALDGGD 220

Query: 274 PRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRY 333
           P R G + + + VLD ND+ P+F Q  YR +V E+   G  V  V ATD D G NG V Y
Sbjct: 221 PIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMY 280

Query: 334 SVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE 393
           S R  +             +  F ++  +G V+V   LD E   ++++ ++ +DGG    
Sbjct: 281 SFRNMESKA----------SEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--L 328

Query: 394 VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453
             T  + I V+DVNDN P I +       +  + E + PG  +A ++V D D        
Sbjct: 329 FTTTTMLITVVDVNDNAPEITI----TSSINSILENSPPGTVIALLNVQDQDSG------ 378

Query: 454 ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
             G++   +    +   LE   G++          + L     LDRE    Y + L ATD
Sbjct: 379 ENGQVSCFI-PNHLPFKLEKTYGNY----------YKLITSRVLDRELVQSYNITLTATD 427

Query: 514 AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDH 573
            GSPPLS E  + L VAD ND PP+F    Y A + E    G  +  V+A D D     +
Sbjct: 428 QGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPD--SKQN 485

Query: 574 AWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKV 633
           A + Y            SL    V         +I+S +G +  +++ D E    +EL+V
Sbjct: 486 ALVTY------------SLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRV 533

Query: 634 VAQDLGEPPLSATCLVSITVDDVNDNEP 661
           +A+D G+PPLS+   +S+ V D NDN P
Sbjct: 534 IARDSGDPPLSSNVSLSLFVLDQNDNAP 561



 Score =  126 bits (316), Expect = 8e-29
 Identities = 117/404 (28%), Positives = 162/404 (40%), Gaps = 54/404 (13%)

Query: 279 LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
           +  VE+ ++D NDN P F++DE    V E A PGA      A D D+G N    Y +   
Sbjct: 117 IYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPN 176

Query: 339 QVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVR 398
                   G   G      V E S        LDRE +A H L++ A DGG       V 
Sbjct: 177 NYFSLQLRGRTDGAKNPELVLEGS--------LDREKEAAHLLLLTALDGGDPIRKGAVP 228

Query: 399 VSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGEL 458
           + + VLDVND+ P    +F        V E    G  V  V+ +D D     E   +   
Sbjct: 229 IRVVVLDVNDHIP----MFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRN 284

Query: 459 GVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPP 518
                     L  + GE               + V G LD E    YE+ +   D G   
Sbjct: 285 MESKASEIFQLDSQTGE---------------VQVRGSLDFEKYRFYEMEIQGQDGGG-- 327

Query: 519 LSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRY 578
           L T  T+L+ V D+ND  P  +      S+ E + PGTV+  ++  D D   +       
Sbjct: 328 LFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQ----- 382

Query: 579 TVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESG---AISTIRTLDREVQEAVELKVVA 635
             V    P +L                F ++   G    + T R LDRE+ ++  + + A
Sbjct: 383 --VSCFIPNHL---------------PFKLEKTYGNYYKLITSRVLDRELVQSYNITLTA 425

Query: 636 QDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVG 679
            D G PPLSA   V + V D NDN P+F    Y+A I E+ P G
Sbjct: 426 TDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRG 469



 Score =  119 bits (298), Expect = 1e-26
 Identities = 126/444 (28%), Positives = 176/444 (39%), Gaps = 83/444 (18%)

Query: 109 DSPLLDDFHVHPDTGIIRTARRLDRERRDHYS-----------FVAATLLGAVVQVEIRV 157
           +S   + F +   TG ++    LD E+   Y            F   T+L  VV      
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVV------ 339

Query: 158 NDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPA 217
            DVND++P   + S    + E SPPGT   L    D D+G       +   P+ LP    
Sbjct: 340 -DVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSG--ENGQVSCFIPNHLP---- 392

Query: 218 GPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRT 277
              F+L  +T G                  L+  R LDRE   ++ + + A D G P  +
Sbjct: 393 ---FKLE-KTYGNY--------------YKLITSRVLDRELVQSYNITLTATDQGSPPLS 434

Query: 278 GLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRA 337
               V L V D+NDNPPVF    Y A + E+   GA +  V A D D   N  V YS+  
Sbjct: 435 AETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTD 494

Query: 338 RQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATV 397
             V G          ++Y ++   +GV+   +  D E     +L V ARD G  P  + V
Sbjct: 495 DTVQGVPL-------SSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNV 547

Query: 398 RVSIAVLDVNDNRPAI-HVLFLTEG--GVARVSEGARPGDYVARVSVSDADGDWEKEDEA 454
            +S+ VLD NDN P I +    T+G  GV      A PG  V +V   D D         
Sbjct: 548 SLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKD--------- 598

Query: 455 TGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYE-------L 507
                          S +     + LL    PG+F +       R +R L +       L
Sbjct: 599 ---------------SGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSL 643

Query: 508 LLVATDAGSPPLSTEETLLLRVAD 531
           ++   D G PPLS   TL + VAD
Sbjct: 644 VVAVQDHGQPPLSATVTLTVAVAD 667



 Score =  113 bits (282), Expect = 7e-25
 Identities = 142/542 (26%), Positives = 216/542 (39%), Gaps = 92/542 (16%)

Query: 131 LDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGT 184
           LDRE+   +  +   L G        V + + V DVNDH P F     ++ V E    GT
Sbjct: 201 LDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGT 260

Query: 185 AFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLE 244
              +  A DPD G+     Y+        +  A   FQL  +T                 
Sbjct: 261 RVLMVNATDPDEGINGEVMYSFRNM----ESKASEIFQLDSQTG---------------- 300

Query: 245 PLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAA 304
             ++ +   LD E+   + ++I+  DGG    T  + +   V+D NDN P         +
Sbjct: 301 --EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLIT--VVDVNDNAPEITITSSINS 356

Query: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSG- 363
           + E++ PG  +  +   D+D G NG V   +    +P              F +E+  G 
Sbjct: 357 ILENSPPGTVIALLNVQDQDSGENGQVSCFI-PNHLP--------------FKLEKTYGN 401

Query: 364 --VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEG 421
              +   R LDRE    + + + A D G+ P  A   V + V D NDN P    +F    
Sbjct: 402 YYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP----VFPHSS 457

Query: 422 GVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALL 481
             A + E    G  +  V+  D D       +    +   L D ++    +G      + 
Sbjct: 458 YSAYIPENNPRGASIFSVTALDPDS------KQNALVTYSLTDDTV----QGVPLSSYVS 507

Query: 482 PGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP--LF 539
                GV +       + + RDL EL ++A D+G PPLS+  +L L V D ND  P  L+
Sbjct: 508 INSNTGVLYALQSFDYE-QFRDL-ELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILY 565

Query: 540 SQQHYKASVS-----EAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQS 594
                  S        +A PG +V  V A D D     +AWL Y +++ S P        
Sbjct: 566 PALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG--QNAWLSYRLLKASEP-------- 615

Query: 595 KMVHTAECGPSFAIDSESGAISTIRTL-DREVQEAVELKVVAQDLGEPPLSATCLVSITV 653
                      FA+   +G + T R L DR+  +   L V  QD G+PPLSAT  +++ V
Sbjct: 616 ---------GLFAVGEHTGEVRTARALLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAV 665

Query: 654 DD 655
            D
Sbjct: 666 AD 667



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 56/194 (28%), Positives = 84/194 (43%), Gaps = 24/194 (12%)

Query: 491 LCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLL-----RVADLNDQPPLFSQQHYK 545
           L   G +DRE  +L E   V++   +  L  E+TL +      + D+ND  P F +   +
Sbjct: 85  LITAGRIDRE--ELCET--VSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVE 140

Query: 546 ASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS 605
             VSE A PG      +A D D   +          QLS P N  SLQ +        P 
Sbjct: 141 IKVSEHAIPGARFALPNARDPDVGVNS-----LQSYQLS-PNNYFSLQLRGRTDGAKNPE 194

Query: 606 FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWR 665
             ++          +LDRE + A  L + A D G+P       + + V DVND+ P+F +
Sbjct: 195 LVLEG---------SLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQ 245

Query: 666 QVYNATIAEHAPVG 679
            VY  ++ E+   G
Sbjct: 246 SVYRVSVPENISSG 259



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 23/78 (29%), Positives = 36/78 (46%), Gaps = 1/78 (1%)

Query: 606 FAIDSESGAISTIRTLDRE-VQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFW 664
           FA++  SG++ T   +DRE + E V    +  +L          V + + D+NDN P F 
Sbjct: 76  FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQ 135

Query: 665 RQVYNATIAEHAPVGHCF 682
                  ++EHA  G  F
Sbjct: 136 EDEVEIKVSEHAIPGARF 153


>gi|14196455 protocadherin gamma subfamily A, 11 isoform 3 precursor
           [Homo sapiens]
          Length = 750

 Score =  239 bits (610), Expect = 6e-63
 Identities = 200/628 (31%), Positives = 290/628 (46%), Gaps = 81/628 (12%)

Query: 42  RTQRSLLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGF 101
           R  RS L LL+ ++L    G  A+   +  SV E     + VG+I   L    ++     
Sbjct: 7   RGDRSRLLLLLCIFLGTLRGFRAR--QIRYSVPEETEKGSFVGNISKDLGLEPRELAKRG 64

Query: 102 FLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHY---SFVAATLLGA----VVQVE 154
                   + L   F V+P +G + TA R+DRE         F+   LL      +  VE
Sbjct: 65  VRIVSRGKTQL---FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVE 121

Query: 155 IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214
           + + D+ND++P F  D +++ VSE + PG  F LP A DPD G+ S Q Y L        
Sbjct: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-------- 173

Query: 215 DPAGPF-FQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGR 273
            P   F  QLR RT G         + +P    +LVL   LDRE+ AAH L + A DGG 
Sbjct: 174 SPNNYFSLQLRGRTDG---------AKNP----ELVLEGSLDREKEAAHLLLLTALDGGD 220

Query: 274 PRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRY 333
           P R G + + + VLD ND+ P+F Q  YR +V E+   G  V  V ATD D G NG V Y
Sbjct: 221 PIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMY 280

Query: 334 SVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPE 393
           S R  +             +  F ++  +G V+V   LD E   ++++ ++ +DGG    
Sbjct: 281 SFRNMESKA----------SEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--L 328

Query: 394 VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDE 453
             T  + I V+DVNDN P I +       +  + E + PG  +A ++V D D        
Sbjct: 329 FTTTTMLITVVDVNDNAPEITI----TSSINSILENSPPGTVIALLNVQDQDSG------ 378

Query: 454 ATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
             G++   +    +   LE   G++          + L     LDRE    Y + L ATD
Sbjct: 379 ENGQVSCFI-PNHLPFKLEKTYGNY----------YKLITSRVLDRELVQSYNITLTATD 427

Query: 514 AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDH 573
            GSPPLS E  + L VAD ND PP+F    Y A + E    G  +  V+A D D     +
Sbjct: 428 QGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPD--SKQN 485

Query: 574 AWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKV 633
           A + Y            SL    V         +I+S +G +  +++ D E    +EL+V
Sbjct: 486 ALVTY------------SLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRV 533

Query: 634 VAQDLGEPPLSATCLVSITVDDVNDNEP 661
           +A+D G+PPLS+   +S+ V D NDN P
Sbjct: 534 IARDSGDPPLSSNVSLSLFVLDQNDNAP 561



 Score =  126 bits (316), Expect = 8e-29
 Identities = 117/404 (28%), Positives = 162/404 (40%), Gaps = 54/404 (13%)

Query: 279 LLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
           +  VE+ ++D NDN P F++DE    V E A PGA      A D D+G N    Y +   
Sbjct: 117 IYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPN 176

Query: 339 QVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVR 398
                   G   G      V E S        LDRE +A H L++ A DGG       V 
Sbjct: 177 NYFSLQLRGRTDGAKNPELVLEGS--------LDREKEAAHLLLLTALDGGDPIRKGAVP 228

Query: 399 VSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGEL 458
           + + VLDVND+ P    +F        V E    G  V  V+ +D D     E   +   
Sbjct: 229 IRVVVLDVNDHIP----MFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRN 284

Query: 459 GVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPP 518
                     L  + GE               + V G LD E    YE+ +   D G   
Sbjct: 285 MESKASEIFQLDSQTGE---------------VQVRGSLDFEKYRFYEMEIQGQDGGG-- 327

Query: 519 LSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRY 578
           L T  T+L+ V D+ND  P  +      S+ E + PGTV+  ++  D D   +       
Sbjct: 328 LFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQ----- 382

Query: 579 TVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESG---AISTIRTLDREVQEAVELKVVA 635
             V    P +L                F ++   G    + T R LDRE+ ++  + + A
Sbjct: 383 --VSCFIPNHL---------------PFKLEKTYGNYYKLITSRVLDRELVQSYNITLTA 425

Query: 636 QDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVG 679
            D G PPLSA   V + V D NDN P+F    Y+A I E+ P G
Sbjct: 426 TDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRG 469



 Score =  110 bits (275), Expect = 4e-24
 Identities = 105/351 (29%), Positives = 146/351 (41%), Gaps = 52/351 (14%)

Query: 109 DSPLLDDFHVHPDTGIIRTARRLDRERRDHYS-----------FVAATLLGAVVQVEIRV 157
           +S   + F +   TG ++    LD E+   Y            F   T+L  VV      
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVV------ 339

Query: 158 NDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPA 217
            DVND++P   + S    + E SPPGT   L    D D+G       +   P+ LP    
Sbjct: 340 -DVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSG--ENGQVSCFIPNHLP---- 392

Query: 218 GPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRT 277
              F+L  +T G                  L+  R LDRE   ++ + + A D G P  +
Sbjct: 393 ---FKLE-KTYGNY--------------YKLITSRVLDRELVQSYNITLTATDQGSPPLS 434

Query: 278 GLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRA 337
               V L V D+NDNPPVF    Y A + E+   GA +  V A D D   N  V YS+  
Sbjct: 435 AETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTD 494

Query: 338 RQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATV 397
             V G          ++Y ++   +GV+   +  D E     +L V ARD G  P  + V
Sbjct: 495 DTVQGVPL-------SSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNV 547

Query: 398 RVSIAVLDVNDNRPAI-HVLFLTEG--GVARVSEGARPGDYVARVSVSDAD 445
            +S+ VLD NDN P I +    T+G  GV      A PG  V +V   D D
Sbjct: 548 SLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKD 598



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 66/242 (27%), Positives = 98/242 (40%), Gaps = 34/242 (14%)

Query: 127 TARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS 180
           T+R LDRE    Y+            L A   V + V D ND+ P FP  S    + E +
Sbjct: 407 TSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENN 466

Query: 181 PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG-PLPSPLLPGS 239
           P G +     A DPD+   +   Y+L   +                  G PL S +   S
Sbjct: 467 PRGASIFSVTALDPDSKQNALVTYSLTDDT----------------VQGVPLSSYVSINS 510

Query: 240 SSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVF--- 296
           ++ +    L  L+  D E+     L++ A D G P  +  +S+ L VLD+NDN P     
Sbjct: 511 NTGV----LYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYP 566

Query: 297 ----EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD 352
               +           A+PG  V +V A D+D G N ++ Y +     PG  + G   G+
Sbjct: 567 ALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGE 626

Query: 353 AA 354
            A
Sbjct: 627 QA 628



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 56/194 (28%), Positives = 84/194 (43%), Gaps = 24/194 (12%)

Query: 491 LCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLL-----RVADLNDQPPLFSQQHYK 545
           L   G +DRE  +L E   V++   +  L  E+TL +      + D+ND  P F +   +
Sbjct: 85  LITAGRIDRE--ELCET--VSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVE 140

Query: 546 ASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS 605
             VSE A PG      +A D D   +          QLS P N  SLQ +        P 
Sbjct: 141 IKVSEHAIPGARFALPNARDPDVGVNS-----LQSYQLS-PNNYFSLQLRGRTDGAKNPE 194

Query: 606 FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWR 665
             ++          +LDRE + A  L + A D G+P       + + V DVND+ P+F +
Sbjct: 195 LVLEG---------SLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQ 245

Query: 666 QVYNATIAEHAPVG 679
            VY  ++ E+   G
Sbjct: 246 SVYRVSVPENISSG 259



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 23/78 (29%), Positives = 36/78 (46%), Gaps = 1/78 (1%)

Query: 606 FAIDSESGAISTIRTLDRE-VQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFW 664
           FA++  SG++ T   +DRE + E V    +  +L          V + + D+NDN P F 
Sbjct: 76  FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQ 135

Query: 665 RQVYNATIAEHAPVGHCF 682
                  ++EHA  G  F
Sbjct: 136 EDEVEIKVSEHAIPGARF 153


>gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  237 bits (604), Expect = 3e-62
 Identities = 180/553 (32%), Positives = 263/553 (47%), Gaps = 74/553 (13%)

Query: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFP 168
           F ++P +G + TA R+DRE     +      L  +++       VE+ V D+ND++P F 
Sbjct: 75  FALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFR 134

Query: 169 LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
              L++ +SE +     F LP A DPD G  S Q Y L                    +P
Sbjct: 135 ESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYEL--------------------SP 174

Query: 229 GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
               S ++   +   +  +LVL R LDREE AAH L + A DGG P RTG   + + VLD
Sbjct: 175 NTHFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLD 234

Query: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
            NDN P F Q EYRA+V E+   G ++  V ATD D G N  VRYS R            
Sbjct: 235 ANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKA------ 288

Query: 349 ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVND 408
               A  F ++  SG +     LD E   ++Q+ V+A D       A  +V I VLDVND
Sbjct: 289 ----AQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYS--ARAKVLITVLDVND 342

Query: 409 NRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS 468
           N P + +  L     + V E +  G  +A ++V+D D       E  G++ +    G++ 
Sbjct: 343 NAPEVVLTSL----ASSVPENSPRGTLIALLNVNDQD------SEENGQV-ICFIQGNLP 391

Query: 469 LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLR 528
             LE   G++          + L  +  LDRE    Y + + ATD G+PPLSTE  + L 
Sbjct: 392 FKLEKSYGNY----------YSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLN 441

Query: 529 VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
           VAD ND PP+F Q  Y A + E    G  ++ V+A D D    ++A + Y          
Sbjct: 442 VADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPD--CEENAQITY---------- 489

Query: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
             SL    +  A      +I+S++G +  + + D E    +++KV+A+D G PPLS+   
Sbjct: 490 --SLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVS 547

Query: 649 VSITVDDVNDNEP 661
           +S+ V D NDN P
Sbjct: 548 LSLFVLDQNDNAP 560



 Score =  115 bits (287), Expect = 2e-25
 Identities = 119/445 (26%), Positives = 170/445 (38%), Gaps = 73/445 (16%)

Query: 248 LVLLRRLDREEAAAHRLQIEA-WDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306
           LV   R+DREE     ++ +   D     +  +  VE+ V D NDN P F + E    + 
Sbjct: 84  LVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKIS 143

Query: 307 EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
           E+A          A D D+G N    Y +            GA G      V +      
Sbjct: 144 ENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPELVLK------ 197

Query: 367 VWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARV 426
             R LDRE +A H LV+ A DGG      T R+ + VLD NDN PA    F      A V
Sbjct: 198 --RALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPA----FAQPEYRASV 251

Query: 427 SEGARPGDYVARVSVSDADGDWEKE---------DEATGELGVGLGDGSISLSLEGGEGD 477
            E    G  +  V+ +D D     E         D+A     +    G+IS         
Sbjct: 252 PENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTI------- 304

Query: 478 FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
                            G LD E    Y++ + A D      S    +L+ V D+ND  P
Sbjct: 305 -----------------GELDHEESGFYQMEVQAMDNAG--YSARAKVLITVLDVNDNAP 345

Query: 538 LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
                   +SV E +  GT++  ++ +D D   +         +Q + P           
Sbjct: 346 EVVLTSLASSVPENSPRGTLIALLNVNDQDSEENGQV---ICFIQGNLP----------- 391

Query: 598 HTAECGPSFAIDSESGAISTIRT---LDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
                   F ++   G   ++ T   LDRE   +  + V A D G PPLS    +S+ V 
Sbjct: 392 --------FKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVA 443

Query: 655 DVNDNEPIFWRQVYNATIAEHAPVG 679
           D NDN P+F +  Y+A I E+ P G
Sbjct: 444 DTNDNPPVFPQASYSAYIPENNPRG 468



 Score =  112 bits (279), Expect = 2e-24
 Identities = 145/545 (26%), Positives = 225/545 (41%), Gaps = 94/545 (17%)

Query: 129 RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           R LDRE +  +  V     G         ++ + V D ND++P F     +  V E    
Sbjct: 198 RALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPENLAL 257

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           GT   +  A DPD G+ +   Y+     D     A   F+L   +          G+ S 
Sbjct: 258 GTQLLVVNATDPDEGVNAEVRYSFRYVDD----KAAQVFKLDCNS----------GTIST 303

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWDG-GRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
           +          LD EE+  ++++++A D  G   R  +L   + VLD NDN P       
Sbjct: 304 IG--------ELDHEESGFYQMEVQAMDNAGYSARAKVL---ITVLDVNDNAPEVVLTSL 352

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNG----FVRYSVRARQVPGAGSGGGALGDAAYFA 357
            ++V E++  G  +  +   D+D   NG    F++ ++  +     G+         Y++
Sbjct: 353 ASSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGN---------YYS 403

Query: 358 VEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417
           +  ++ +V     LDRE    + + V A D G  P      +S+ V D NDN P    +F
Sbjct: 404 L--VTDIV-----LDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPP----VF 452

Query: 418 LTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGD 477
                 A + E    G  V+ VSV+  D D E+  + T  L      G+   S      D
Sbjct: 453 PQASYSAYIPENNPRG--VSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSD 510

Query: 478 FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
                    GV +       + + RDL ++ ++A D G PPLS+  +L L V D ND  P
Sbjct: 511 --------TGVLYALSSFDYE-QFRDL-QVKVMARDNGHPPLSSNVSLSLFVLDQNDNAP 560

Query: 538 --LFSQQHYKASVS-----EAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
             L+       S        +A PG +V  V A D D     +AWL Y +++ S P    
Sbjct: 561 EILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG--QNAWLSYRLLKASEP---- 614

Query: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVS 650
            L S  +HT E   + A+            LDR+  +   L V  QD G+PPLSAT  ++
Sbjct: 615 GLFSVGLHTGEVRTARAL------------LDRDALKQ-SLVVAVQDHGQPPLSATVTLT 661

Query: 651 ITVDD 655
           + V D
Sbjct: 662 VAVAD 666



 Score = 30.8 bits (68), Expect = 4.5
 Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 606 FAIDSESGAISTIRTLDRE--VQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIF 663
           FA++  SG++ T   +DRE     A++ ++    L E  +     V + V D+NDN P F
Sbjct: 75  FALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYG-VEVEVRDINDNAPYF 133

Query: 664 WRQVYNATIAEHA 676
                   I+E+A
Sbjct: 134 RESELEIKISENA 146


>gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  237 bits (604), Expect = 3e-62
 Identities = 180/553 (32%), Positives = 263/553 (47%), Gaps = 74/553 (13%)

Query: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQ-------VEIRVNDVNDHSPRFP 168
           F ++P +G + TA R+DRE     +      L  +++       VE+ V D+ND++P F 
Sbjct: 75  FALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFR 134

Query: 169 LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
              L++ +SE +     F LP A DPD G  S Q Y L                    +P
Sbjct: 135 ESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYEL--------------------SP 174

Query: 229 GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
               S ++   +   +  +LVL R LDREE AAH L + A DGG P RTG   + + VLD
Sbjct: 175 NTHFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLD 234

Query: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
            NDN P F Q EYRA+V E+   G ++  V ATD D G N  VRYS R            
Sbjct: 235 ANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKA------ 288

Query: 349 ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVND 408
               A  F ++  SG +     LD E   ++Q+ V+A D       A  +V I VLDVND
Sbjct: 289 ----AQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYS--ARAKVLITVLDVND 342

Query: 409 NRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS 468
           N P + +  L     + V E +  G  +A ++V+D D       E  G++ +    G++ 
Sbjct: 343 NAPEVVLTSL----ASSVPENSPRGTLIALLNVNDQD------SEENGQV-ICFIQGNLP 391

Query: 469 LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLR 528
             LE   G++          + L  +  LDRE    Y + + ATD G+PPLSTE  + L 
Sbjct: 392 FKLEKSYGNY----------YSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLN 441

Query: 529 VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
           VAD ND PP+F Q  Y A + E    G  ++ V+A D D    ++A + Y          
Sbjct: 442 VADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPD--CEENAQITY---------- 489

Query: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
             SL    +  A      +I+S++G +  + + D E    +++KV+A+D G PPLS+   
Sbjct: 490 --SLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVS 547

Query: 649 VSITVDDVNDNEP 661
           +S+ V D NDN P
Sbjct: 548 LSLFVLDQNDNAP 560



 Score =  115 bits (287), Expect = 2e-25
 Identities = 119/445 (26%), Positives = 170/445 (38%), Gaps = 73/445 (16%)

Query: 248 LVLLRRLDREEAAAHRLQIEA-WDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306
           LV   R+DREE     ++ +   D     +  +  VE+ V D NDN P F + E    + 
Sbjct: 84  LVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKIS 143

Query: 307 EDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR 366
           E+A          A D D+G N    Y +            GA G      V +      
Sbjct: 144 ENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPELVLK------ 197

Query: 367 VWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARV 426
             R LDRE +A H LV+ A DGG      T R+ + VLD NDN PA    F      A V
Sbjct: 198 --RALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPA----FAQPEYRASV 251

Query: 427 SEGARPGDYVARVSVSDADGDWEKE---------DEATGELGVGLGDGSISLSLEGGEGD 477
            E    G  +  V+ +D D     E         D+A     +    G+IS         
Sbjct: 252 PENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTI------- 304

Query: 478 FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
                            G LD E    Y++ + A D      S    +L+ V D+ND  P
Sbjct: 305 -----------------GELDHEESGFYQMEVQAMDNAG--YSARAKVLITVLDVNDNAP 345

Query: 538 LFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMV 597
                   +SV E +  GT++  ++ +D D   +         +Q + P           
Sbjct: 346 EVVLTSLASSVPENSPRGTLIALLNVNDQDSEENGQV---ICFIQGNLP----------- 391

Query: 598 HTAECGPSFAIDSESGAISTIRT---LDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654
                   F ++   G   ++ T   LDRE   +  + V A D G PPLS    +S+ V 
Sbjct: 392 --------FKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVA 443

Query: 655 DVNDNEPIFWRQVYNATIAEHAPVG 679
           D NDN P+F +  Y+A I E+ P G
Sbjct: 444 DTNDNPPVFPQASYSAYIPENNPRG 468



 Score =  112 bits (279), Expect = 2e-24
 Identities = 145/545 (26%), Positives = 225/545 (41%), Gaps = 94/545 (17%)

Query: 129 RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           R LDRE +  +  V     G         ++ + V D ND++P F     +  V E    
Sbjct: 198 RALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPENLAL 257

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           GT   +  A DPD G+ +   Y+     D     A   F+L   +          G+ S 
Sbjct: 258 GTQLLVVNATDPDEGVNAEVRYSFRYVDD----KAAQVFKLDCNS----------GTIST 303

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWDG-GRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
           +          LD EE+  ++++++A D  G   R  +L   + VLD NDN P       
Sbjct: 304 IG--------ELDHEESGFYQMEVQAMDNAGYSARAKVL---ITVLDVNDNAPEVVLTSL 352

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNG----FVRYSVRARQVPGAGSGGGALGDAAYFA 357
            ++V E++  G  +  +   D+D   NG    F++ ++  +     G+         Y++
Sbjct: 353 ASSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGN---------YYS 403

Query: 358 VEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLF 417
           +  ++ +V     LDRE    + + V A D G  P      +S+ V D NDN P    +F
Sbjct: 404 L--VTDIV-----LDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPP----VF 452

Query: 418 LTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGD 477
                 A + E    G  V+ VSV+  D D E+  + T  L      G+   S      D
Sbjct: 453 PQASYSAYIPENNPRG--VSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSD 510

Query: 478 FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
                    GV +       + + RDL ++ ++A D G PPLS+  +L L V D ND  P
Sbjct: 511 --------TGVLYALSSFDYE-QFRDL-QVKVMARDNGHPPLSSNVSLSLFVLDQNDNAP 560

Query: 538 --LFSQQHYKASVS-----EAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
             L+       S        +A PG +V  V A D D     +AWL Y +++ S P    
Sbjct: 561 EILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG--QNAWLSYRLLKASEP---- 614

Query: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVS 650
            L S  +HT E   + A+            LDR+  +   L V  QD G+PPLSAT  ++
Sbjct: 615 GLFSVGLHTGEVRTARAL------------LDRDALKQ-SLVVAVQDHGQPPLSATVTLT 661

Query: 651 ITVDD 655
           + V D
Sbjct: 662 VAVAD 666



 Score = 30.8 bits (68), Expect = 4.5
 Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 606 FAIDSESGAISTIRTLDRE--VQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIF 663
           FA++  SG++ T   +DRE     A++ ++    L E  +     V + V D+NDN P F
Sbjct: 75  FALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYG-VEVEVRDINDNAPYF 133

Query: 664 WRQVYNATIAEHA 676
                   I+E+A
Sbjct: 134 RESELEIKISENA 146


>gi|14196468 protocadherin gamma subfamily A, 4 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  237 bits (604), Expect = 3e-62
 Identities = 178/553 (32%), Positives = 263/553 (47%), Gaps = 74/553 (13%)

Query: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGA-------VVQVEIRVNDVNDHSPRFP 168
           F ++P +G + TA R+DRE     S    T L         +++VE+ + DVND+ P F 
Sbjct: 75  FALNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIIDVNDNPPSFG 134

Query: 169 LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
            +  ++ V+E   PG  F LP A DPD G+ S QGY L          +  +F L  ++ 
Sbjct: 135 TEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQL---------NSNGYFSLDVQS- 184

Query: 229 GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLD 288
                      +  ++  +LVL R LDREE A H L + A+DGG P R+G   + + ++D
Sbjct: 185 ----------GADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVD 234

Query: 289 ENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
            NDN PVF Q EY  +VRE+   G  +  V+ATD D G NG V YS R  +         
Sbjct: 235 TNDNAPVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDK------- 287

Query: 349 ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVND 408
               +  F +  LSG + +   LD E   ++ + VEA DG      A  +V + VLD ND
Sbjct: 288 ---ISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHDGPGLR--ARSKVLVTVLDEND 342

Query: 409 NRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSIS 468
           N P + V  LT    + V E + PG  +A  +V D+D          G +   + D ++ 
Sbjct: 343 NAPEVTVTSLT----SSVQESSSPGTVIALFNVHDSDSG------GNGLVTCSIPD-NLP 391

Query: 469 LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLR 528
            +LE   G++          + L     LDRE    Y + + ATD G+PPLSTE  + L+
Sbjct: 392 FTLEKTYGNY----------YRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQ 441

Query: 529 VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
           V D+ND PP F    Y A + E    G  ++ ++A D D    D+A + Y          
Sbjct: 442 VMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPD--SGDNARITY---------- 489

Query: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL 648
             SL       A      +I+S +G +  + + D E    ++L + A D G+PPLS+   
Sbjct: 490 --SLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVS 547

Query: 649 VSITVDDVNDNEP 661
           +S+ V D NDN P
Sbjct: 548 LSLFVLDQNDNVP 560



 Score =  140 bits (352), Expect = 5e-33
 Identities = 132/458 (28%), Positives = 187/458 (40%), Gaps = 87/458 (18%)

Query: 248 LVLLRRLDREEAAAH------RLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEY 301
           LV   R+DREE           L+I   D  +     +L VE+ ++D NDNPP F  ++ 
Sbjct: 84  LVTAGRIDREELCDRSPNCVTNLEILLEDTVK-----ILRVEVEIIDVNDNPPSFGTEQR 138

Query: 302 RAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEEL 361
              V E+  PGA      A D D+G N    Y + +                 YF+++  
Sbjct: 139 EIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSN---------------GYFSLDVQ 183

Query: 362 SGVVRVWRP-------LDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIH 414
           SG   +  P       LDRE +A H LV+ A DGG      T R+ I ++D NDN P   
Sbjct: 184 SGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAP--- 240

Query: 415 VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS---- 470
            +F        V E    G  +  V  +D D      + A G++          +S    
Sbjct: 241 -VFTQPEYHVSVRENVPVGTRLLTVKATDPD------EGANGDVTYSFRKVRDKISQLFQ 293

Query: 471 LEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVA 530
           L    GD  +L G             LD E    Y++ + A D   P L     +L+ V 
Sbjct: 294 LNSLSGDITILGG-------------LDYEDSGFYDIDVEAHDG--PGLRARSKVLVTVL 338

Query: 531 DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
           D ND  P  +     +SV E+++PGTV+   +  D+D  G+        +V  S P NL 
Sbjct: 339 DENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNG-------LVTCSIPDNL- 390

Query: 591 SLQSKMVHTAECGPSFAIDSESG---AISTIRTLDREVQEAVELKVVAQDLGEPPLSATC 647
                          F ++   G    + T RTLDRE      + V A D G PPLS   
Sbjct: 391 --------------PFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTET 436

Query: 648 LVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQL 685
            +S+ V D+NDN P F    Y+A I E+ P G   L +
Sbjct: 437 HISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSM 474



 Score =  134 bits (336), Expect = 4e-31
 Identities = 154/546 (28%), Positives = 220/546 (40%), Gaps = 96/546 (17%)

Query: 129 RRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPP 182
           R LDRE    +  V     G         ++ I + D ND++P F      + V E  P 
Sbjct: 198 RALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPV 257

Query: 183 GTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSP 242
           GT      A DPD G      Y+  +     +D     FQL            L G    
Sbjct: 258 GTRLLTVKATDPDEGANGDVTYSFRKV----RDKISQLFQLNS----------LSG---- 299

Query: 243 LEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYR 302
               D+ +L  LD E++  + + +EA DG  P       V + VLDENDN P        
Sbjct: 300 ----DITILGGLDYEDSGFYDIDVEAHDG--PGLRARSKVLVTVLDENDNAPEVTVTSLT 353

Query: 303 AAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELS 362
           ++V+E + PG  +      D D G NG V  S+                D   F +E+  
Sbjct: 354 SSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIP---------------DNLPFTLEKTY 398

Query: 363 GV---VRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLT 419
           G    +   R LDRE  + + + V A D G  P      +S+ V+D+NDN P     F  
Sbjct: 399 GNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPT----FPH 454

Query: 420 EGGVARVSEGARPGDYVARVSVSDAD-GDWEKEDEATGELGVGLGDGSISLSLEGGEGDF 478
               A + E    G  +  ++  D D GD  +   +  E        S  +S+    G  
Sbjct: 455 ASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINSNTGI- 513

Query: 479 ALLPGGPPGVFFLCVEGPLDRES-RDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPP 537
                    ++ LC     D E  RDL +LL+ A+D+G PPLS+  +L L V D ND  P
Sbjct: 514 ---------LYALC---SFDYEQFRDL-QLLMTASDSGDPPLSSNVSLSLFVLDQNDNVP 560

Query: 538 --LFSQQHYKASVSEAAAP-----GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
             L+       S     AP     G +V  V A D D     +AWL Y++++ S P    
Sbjct: 561 EILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSG--QNAWLSYSLLKSSEP---- 614

Query: 591 SLQSKMVHTAECGPSFAIDSESGAISTIRTL-DREVQEAVELKVVAQDLGEPPLSATCLV 649
                          FA+   +G + T R L DR+  +   L VV QD G+PPLSAT  +
Sbjct: 615 -------------GLFAVGLHTGEVRTARALLDRDALKQ-RLVVVVQDHGQPPLSATVTL 660

Query: 650 SITVDD 655
           ++ V D
Sbjct: 661 TVAVAD 666


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,601,343
Number of Sequences: 37866
Number of extensions: 1581445
Number of successful extensions: 11211
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 4787
Number of HSP's gapped (non-prelim): 1704
length of query: 709
length of database: 18,247,518
effective HSP length: 109
effective length of query: 600
effective length of database: 14,120,124
effective search space: 8472074400
effective search space used: 8472074400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.