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Search of human proteins with 21618349
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
(347 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 700 0.0
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 644 0.0
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi... 537 e-153
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 472 e-133
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens] 342 2e-94
gi|239751247 PREDICTED: similar to mitogen-activated protein kin... 310 2e-84
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi... 259 2e-69
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 209 2e-54
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ... 209 2e-54
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi... 205 4e-53
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [... 197 9e-51
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 165 5e-41
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 160 2e-39
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 144 2e-34
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 131 1e-30
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 131 1e-30
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 131 1e-30
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 131 1e-30
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 131 1e-30
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 131 1e-30
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 131 1e-30
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 131 1e-30
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 127 1e-29
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 127 1e-29
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 127 1e-29
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 127 1e-29
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 127 1e-29
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 127 1e-29
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 127 1e-29
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 127 2e-29
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 700 bits (1807), Expect = 0.0
Identities = 347/347 (100%), Positives = 347/347 (100%)
Query: 1 MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE 60
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE
Sbjct: 1 MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE 60
Query: 61 ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC 120
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
Sbjct: 61 ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC 120
Query: 121 FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL 180
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
Sbjct: 121 FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL 180
Query: 181 HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL 240
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
Sbjct: 181 HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL 240
Query: 241 NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD 300
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
Sbjct: 241 NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD 300
Query: 301 FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS 347
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
Sbjct: 301 FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS 347
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 644 bits (1661), Expect = 0.0
Identities = 318/318 (100%), Positives = 318/318 (100%)
Query: 30 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 89
MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI
Sbjct: 1 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 60
Query: 90 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 149
MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK
Sbjct: 61 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 120
Query: 150 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 209
FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF
Sbjct: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
Query: 210 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 269
GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE
Sbjct: 181 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 240
Query: 270 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 329
SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK
Sbjct: 241 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 300
Query: 330 TKKTDIAAFVKEILGEDS 347
TKKTDIAAFVKEILGEDS
Sbjct: 301 TKKTDIAAFVKEILGEDS 318
>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
Length = 334
Score = 537 bits (1384), Expect = e-153
Identities = 268/335 (80%), Positives = 301/335 (89%), Gaps = 2/335 (0%)
Query: 12 MPQSKGKSKRKKDLRISCMS-KPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISEL 70
M QSKGK KR L+I + + P + TPPR+LDS+ I+IG++NFEV+ADDL I EL
Sbjct: 1 MSQSKGK-KRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMEL 59
Query: 71 GRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGAL 130
GRGAYGVVEK+RH SG IMAVKRIRATVNSQEQKRLLMDLDI+MRTVDC +TVTFYGAL
Sbjct: 60 GRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL 119
Query: 131 FREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRD 190
FREGDVWICMELMDTSLDKFY++V+DK TIPEDILG+IAVSIV+ALEHLHSKLSVIHRD
Sbjct: 120 FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRD 179
Query: 191 VKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSD 250
VKPSNVLIN G VKMCDFGISGYLVDSVAKT+DAGCKPYMAPERINPELNQKGY+VKSD
Sbjct: 180 VKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSD 239
Query: 251 VWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNP 310
+WSLGITMIE+AILRFPY+SWGTPFQQLKQVVEEPSPQLPAD+FS EFVDFT+QCL+KN
Sbjct: 240 IWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNS 299
Query: 311 AERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGE 345
ER +Y ELM+HPFFTLH++K TD+A+FVK ILG+
Sbjct: 300 KERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 472 bits (1214), Expect = e-133
Identities = 236/249 (94%), Positives = 237/249 (95%)
Query: 17 GKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYG 76
GKSKRKKDLRISCMSKPPAPNPT PRNLDSRTFITIGD NFEVEADDLVTI ELGRGAYG
Sbjct: 22 GKSKRKKDLRISCMSKPPAPNPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYG 81
Query: 77 VVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDV 136
VVEKVRH QSGTIMAVK I ATVNS EQKRLLMDLDINMRTVDCFYTVTFYGALFREGDV
Sbjct: 82 VVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDV 141
Query: 137 WICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNV 196
WICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNV
Sbjct: 142 WICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNV 201
Query: 197 LINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGI 256
LINKEGHVKMCDFGISGYLVDSVAK MDAGCKPYMAPERINPELNQKGYNVKSDVWSLGI
Sbjct: 202 LINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGI 261
Query: 257 TMIEMAILR 265
TM +LR
Sbjct: 262 TMGRALLLR 270
>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
Length = 399
Score = 342 bits (878), Expect = 2e-94
Identities = 182/369 (49%), Positives = 251/369 (68%), Gaps = 33/369 (8%)
Query: 3 SPASSQPASMPQSKGKSKRKKDLRISCMSKPPA---------PNPTPPRN---------- 43
SPA PA + +GK +K L+++ + PP PNPT +N
Sbjct: 26 SPAPGHPA-VSSMQGK---RKALKLN-FANPPFKSTARFTLNPNPTGVQNPHIERLRTHS 80
Query: 44 LDSRTFITIG-DRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQ 102
++S + I +++++ A+DL + E+GRGAYG V K+ H SG IMAVKRIR+TV+ +
Sbjct: 81 IESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEK 140
Query: 103 EQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYR---KVLDKNM 159
EQK+LLMDLD+ MR+ DC Y V FYGALFREGD WICMELM TS DKFY+ VLD
Sbjct: 141 EQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDD-- 198
Query: 160 TIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSV 219
IPE+ILG+I ++ V+AL HL L +IHRD+KPSN+L+++ G++K+CDFGISG LVDS+
Sbjct: 199 VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSI 258
Query: 220 AKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLK 279
AKT DAGC+PYMAPERI+P +++GY+V+SDVWSLGIT+ E+A RFPY W + F QL
Sbjct: 259 AKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLT 318
Query: 280 QVVEEPSPQLPAD---RFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIA 336
QVV+ PQL FSP F++F CL K+ ++R Y EL++HPF +++ + ++A
Sbjct: 319 QVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVA 378
Query: 337 AFVKEILGE 345
+V +IL +
Sbjct: 379 CYVCKILDQ 387
>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
kinase 3 [Homo sapiens]
Length = 198
Score = 310 bits (793), Expect = 2e-84
Identities = 150/150 (100%), Positives = 150/150 (100%)
Query: 109 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 168
MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE
Sbjct: 1 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
Query: 169 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 228
IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK
Sbjct: 61 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
Query: 229 PYMAPERINPELNQKGYNVKSDVWSLGITM 258
PYMAPERINPELNQKGYNVKSDVWSLGITM
Sbjct: 121 PYMAPERINPELNQKGYNVKSDVWSLGITM 150
>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
Length = 419
Score = 259 bits (663), Expect = 2e-69
Identities = 130/299 (43%), Positives = 202/299 (67%), Gaps = 5/299 (1%)
Query: 49 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 108
++TIG + ++ E +DL + E+G G G V K+R ++G ++AVK++R + N +E KR+L
Sbjct: 105 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL 164
Query: 109 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 168
MDLD+ +++ DC Y V +G DV+I MELM T +K +++ IPE ILG+
Sbjct: 165 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP---IPERILGK 221
Query: 169 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 228
+ V+IV+AL +L K VIHRDVKPSN+L+++ G +K+CDFGISG LVDS AKT AGC
Sbjct: 222 MTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA 281
Query: 229 PYMAPERIN-PELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSP 287
YMAPERI+ P+ + Y++++DVWSLGI+++E+A +FPY++ T F+ L +V++E P
Sbjct: 282 AYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPP 341
Query: 288 QLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGE 345
LP FS +F F CL K+ +R Y +L+EH F ++T + D+A++ K+++ +
Sbjct: 342 LLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK 400
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 209 bits (533), Expect = 2e-54
Identities = 124/338 (36%), Positives = 187/338 (55%), Gaps = 52/338 (15%)
Query: 49 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 108
F+T + E++ DD ISELG G GVV KV H SG +MA K I + + +++
Sbjct: 53 FLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII 112
Query: 109 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILG 167
+L + + + Y V FYGA + +G++ ICME MD SLD+ VL K IPE ILG
Sbjct: 113 RELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKKAGRIPEQILG 167
Query: 168 EIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGC 227
++++++++ L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G
Sbjct: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 226
Query: 228 KPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPY------------------E 269
+ YM+PER L Y+V+SD+WS+G++++EMA+ R+P +
Sbjct: 227 RSYMSPER----LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGD 282
Query: 270 SWGTP-----------------------FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCL 306
+ TP F+ L +V EP P+LP+ FS EF DF +CL
Sbjct: 283 AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCL 342
Query: 307 RKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILG 344
KNPAER +LM H F ++ D A ++ +G
Sbjct: 343 IKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380
>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
Length = 448
Score = 209 bits (533), Expect = 2e-54
Identities = 124/275 (45%), Positives = 166/275 (60%), Gaps = 20/275 (7%)
Query: 56 NFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINM 115
N ++ D+ LG G G V K H SG I+AVK I + + QK+++ +L+I +
Sbjct: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
Query: 116 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 175
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
Query: 176 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER 235
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AKT G YMAPER
Sbjct: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
Query: 236 INPELNQKGYNVKSDVWSLGITMIEMAILRFPY----ESWGT--PFQQLKQVVEEPSPQL 289
I+ E Y + SDVWSLGI+ +E+A+ RFPY ++ G+ P Q L+ +V+E SP L
Sbjct: 328 ISGE----QYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVL 383
Query: 290 PADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
P FS FV F QC+RK P ER + ELM HPF
Sbjct: 384 PVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPF 418
>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
Length = 400
Score = 205 bits (522), Expect = 4e-53
Identities = 122/341 (35%), Positives = 187/341 (54%), Gaps = 56/341 (16%)
Query: 49 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 108
F+T + E++ DD ISELG G GVV KV+H SG IMA K I + + +++
Sbjct: 57 FLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQII 116
Query: 109 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILG 167
+L + + + Y V FYGA + +G++ ICME MD SLD+ VL + IPE+ILG
Sbjct: 117 RELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKEAKRIPEEILG 171
Query: 168 EIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGC 227
+++++++R L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G
Sbjct: 172 KVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 230
Query: 228 KPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYES---------WGTP---- 274
+ YMAPER L Y+V+SD+WS+G++++E+A+ R+P +G P
Sbjct: 231 RSYMAPER----LQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDG 286
Query: 275 --------------------------------FQQLKQVVEEPSPQLPADRFSPEFVDFT 302
F+ L +V EP P+LP F+P+F +F
Sbjct: 287 EEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFV 346
Query: 303 AQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEIL 343
+CL KNPAER L H F + ++ D A ++ + L
Sbjct: 347 NKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTL 387
>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
Length = 438
Score = 197 bits (502), Expect = 9e-51
Identities = 119/271 (43%), Positives = 160/271 (59%), Gaps = 22/271 (8%)
Query: 56 NFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINM 115
N ++ D+ LG G G V K H SG I+AVK I + + QK+++ +L+I +
Sbjct: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
Query: 116 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 175
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
Query: 176 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER 235
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AKT G YMAPER
Sbjct: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
Query: 236 INPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGT--PFQQLKQVVEEPSPQLPADR 293
I+ E Y + SDVWSLGI+ +E+ ++ G+ P Q L+ +V+E SP LP
Sbjct: 328 ISGE----QYGIHSDVWSLGISFMEI------QKNQGSLMPLQLLQCIVDEDSPVLPVGE 377
Query: 294 FSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
FS FV F QC+RK P ER + ELM HPF
Sbjct: 378 FSEPFVHFITQCMRKQPKERPAPEELMGHPF 408
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 165 bits (418), Expect = 5e-41
Identities = 106/298 (35%), Positives = 164/298 (55%), Gaps = 24/298 (8%)
Query: 30 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 89
M +PPAP + + L + + F+V + +LG G+YG V K H +SG +
Sbjct: 1 MEQPPAPK-SKLKKLSEDSLTKQPEEVFDV-------LEKLGEGSYGSVFKAIHKESGQV 52
Query: 90 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLD 148
+A+K++ + QE ++ ++ I M+ D Y V +YG+ F+ D+WI ME S+
Sbjct: 53 VAIKQVPVESDLQE---IIKEISI-MQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVS 108
Query: 149 KFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCD 208
R +N T+ ED + I S ++ LE+LH + IHRD+K N+L+N EGH K+ D
Sbjct: 109 DIIRL---RNKTLIEDEIATILKSTLKGLEYLHF-MRKIHRDIKAGNILLNTEGHAKLAD 164
Query: 209 FGISGYLVDSVAKTMDA-GCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFP 267
FG++G L D++AK G +MAPE I + GYN +D+WSLGIT IEMA + P
Sbjct: 165 FGVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEIGYNCVADIWSLGITSIEMAEGKPP 220
Query: 268 YESWGTPFQQLKQVVEEPSPQL-PADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
Y P + + + P P + +S +F DF +CL KNP +R + +L++HPF
Sbjct: 221 YADI-HPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPF 277
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 160 bits (404), Expect = 2e-39
Identities = 97/261 (37%), Positives = 149/261 (57%), Gaps = 16/261 (6%)
Query: 67 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTF 126
+ +LG G+YG V K H ++G I+A+K++ + QE ++ ++ I M+ D + V +
Sbjct: 33 LEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE---IIKEISI-MQQCDSPHVVKY 88
Query: 127 YGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLS 185
YG+ F+ D+WI ME S+ R +N T+ ED + I S ++ LE+LH +
Sbjct: 89 YGSYFKNTDLWIVMEYCGAGSVSDIIRL---RNKTLTEDEIATILQSTLKGLEYLHF-MR 144
Query: 186 VIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDA-GCKPYMAPERINPELNQKG 244
IHRD+K N+L+N EGH K+ DFG++G L D++AK G +MAPE I + G
Sbjct: 145 KIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEIG 200
Query: 245 YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQL-PADRFSPEFVDFTA 303
YN +D+WSLGIT IEMA + PY P + + + P P + +S F DF
Sbjct: 201 YNCVADIWSLGITAIEMAEGKPPYADI-HPMRAIFMIPTNPPPTFRKPELWSDNFTDFVK 259
Query: 304 QCLRKNPAERMSYLELMEHPF 324
QCL K+P +R + +L++HPF
Sbjct: 260 QCLVKSPEQRATATQLLQHPF 280
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 144 bits (362), Expect = 2e-34
Identities = 96/284 (33%), Positives = 151/284 (53%), Gaps = 10/284 (3%)
Query: 67 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTF 126
+ ELG GA+G V K ++ ++G + A K I T + +E + +++++I + T D Y V
Sbjct: 39 VGELGDGAFGKVYKAKNKETGALAAAKVIE-TKSEEELEDYIVEIEI-LATCDHPYIVKL 96
Query: 127 YGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSV 186
GA + +G +WI +E LD+ +T P+ + + ++ AL LHSK +
Sbjct: 97 LGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQ--IQVVCRQMLEALNFLHSK-RI 153
Query: 187 IHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERINPE-LNQKG 244
IHRD+K NVL+ EG +++ DFG+S + ++ K PY MAPE + E +
Sbjct: 154 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 213
Query: 245 YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQ 304
Y+ K+D+WSLGIT+IEMA + P+ LK +P L ++S EF DF
Sbjct: 214 YDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKI 273
Query: 305 CLRKNPAERMSYLELMEHPF---FTLHKTKKTDIAAFVKEILGE 345
L KNP R S +L+EHPF T +K + +A E++ E
Sbjct: 274 ALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEE 317
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 131 bits (329), Expect = 1e-30
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 39 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 98
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 99 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 149
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 150 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 209
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 210 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 267
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 268 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 131 bits (329), Expect = 1e-30
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 39 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 98
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 99 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 149
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 150 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 209
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 210 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 267
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 268 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 131 bits (329), Expect = 1e-30
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 39 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 98
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 99 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 149
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 150 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 209
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 210 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 267
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 268 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 131 bits (329), Expect = 1e-30
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 39 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 98
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 99 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 149
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 150 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 209
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 210 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 267
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 268 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 131 bits (329), Expect = 1e-30
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 39 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 98
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 99 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 149
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 150 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 209
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 210 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 267
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 268 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 131 bits (329), Expect = 1e-30
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 39 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 98
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 99 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 149
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 150 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 209
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 210 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 267
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 268 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 131 bits (329), Expect = 1e-30
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 39 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 98
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 99 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 149
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 150 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 209
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 210 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 267
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 268 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 131 bits (329), Expect = 1e-30
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 39 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 98
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 99 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 149
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 150 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 209
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 210 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 267
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 268 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 127 bits (319), Expect = 1e-29
Identities = 97/307 (31%), Positives = 148/307 (48%), Gaps = 24/307 (7%)
Query: 37 NPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIR 96
+P P R+LD + D A + +G G YG V K RH ++G + A+K +
Sbjct: 3 DPAPARSLDDIDLSALRD-----PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 97 ATVNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SL 147
T + +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 58 VTEDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSV 113
Query: 148 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 207
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+
Sbjct: 114 TDLVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLV 170
Query: 208 DFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILR 265
DFG+S L +V + PY MAPE I + N Y+ +SD+WSLGIT IEMA
Sbjct: 171 DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGA 230
Query: 266 FPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF 325
P P + L + P P+L + ++S +F+DF CL K R +L++ PF
Sbjct: 231 PPLCDM-HPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
Query: 326 TLHKTKK 332
T++
Sbjct: 290 RDQPTER 296
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 127 bits (319), Expect = 1e-29
Identities = 97/307 (31%), Positives = 148/307 (48%), Gaps = 24/307 (7%)
Query: 37 NPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIR 96
+P P R+LD + D A + +G G YG V K RH ++G + A+K +
Sbjct: 3 DPAPARSLDDIDLSALRD-----PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 97 ATVNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SL 147
T + +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 58 VTEDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSV 113
Query: 148 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 207
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+
Sbjct: 114 TDLVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLV 170
Query: 208 DFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILR 265
DFG+S L +V + PY MAPE I + N Y+ +SD+WSLGIT IEMA
Sbjct: 171 DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGA 230
Query: 266 FPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF 325
P P + L + P P+L + ++S +F+DF CL K R +L++ PF
Sbjct: 231 PPLCDM-HPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
Query: 326 TLHKTKK 332
T++
Sbjct: 290 RDQPTER 296
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 127 bits (319), Expect = 1e-29
Identities = 97/307 (31%), Positives = 148/307 (48%), Gaps = 24/307 (7%)
Query: 37 NPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIR 96
+P P R+LD + D A + +G G YG V K RH ++G + A+K +
Sbjct: 3 DPAPARSLDDIDLSALRD-----PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 97 ATVNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SL 147
T + +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 58 VTEDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSV 113
Query: 148 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 207
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+
Sbjct: 114 TDLVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLV 170
Query: 208 DFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILR 265
DFG+S L +V + PY MAPE I + N Y+ +SD+WSLGIT IEMA
Sbjct: 171 DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGA 230
Query: 266 FPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF 325
P P + L + P P+L + ++S +F+DF CL K R +L++ PF
Sbjct: 231 PPLCDM-HPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
Query: 326 TLHKTKK 332
T++
Sbjct: 290 RDQPTER 296
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 127 bits (319), Expect = 1e-29
Identities = 97/307 (31%), Positives = 148/307 (48%), Gaps = 24/307 (7%)
Query: 37 NPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIR 96
+P P R+LD + D A + +G G YG V K RH ++G + A+K +
Sbjct: 3 DPAPARSLDDIDLSALRD-----PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 97 ATVNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SL 147
T + +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 58 VTEDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSV 113
Query: 148 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 207
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+
Sbjct: 114 TDLVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLV 170
Query: 208 DFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILR 265
DFG+S L +V + PY MAPE I + N Y+ +SD+WSLGIT IEMA
Sbjct: 171 DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGA 230
Query: 266 FPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF 325
P P + L + P P+L + ++S +F+DF CL K R +L++ PF
Sbjct: 231 PPLCDM-HPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
Query: 326 TLHKTKK 332
T++
Sbjct: 290 RDQPTER 296
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 127 bits (319), Expect = 1e-29
Identities = 92/269 (34%), Positives = 138/269 (51%), Gaps = 19/269 (7%)
Query: 67 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYT--V 124
+ +G G YG V K RH ++G + A+K + T + +E+ + L+INM +
Sbjct: 28 VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE----IKLEINMLKKYSHHRNIA 83
Query: 125 TFYGALFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRAL 177
T+YGA ++ +W+ ME S+ + K T+ ED + I+ I+R L
Sbjct: 84 TYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT--KGNTLKEDWIAYISREILRGL 141
Query: 178 EHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERI 236
HLH VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I
Sbjct: 142 AHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200
Query: 237 NPELNQKG-YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFS 295
+ N Y+ +SD+WS GIT IEMA P P + L + P P+L + ++S
Sbjct: 201 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDM-HPMRALFLIPRNPPPRLKSKKWS 259
Query: 296 PEFVDFTAQCLRKNPAERMSYLELMEHPF 324
+F F CL KN +R S +L++HPF
Sbjct: 260 KKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 127 bits (319), Expect = 1e-29
Identities = 92/269 (34%), Positives = 138/269 (51%), Gaps = 19/269 (7%)
Query: 67 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYT--V 124
+ +G G YG V K RH ++G + A+K + T + +E+ + L+INM +
Sbjct: 28 VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE----IKLEINMLKKYSHHRNIA 83
Query: 125 TFYGALFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRAL 177
T+YGA ++ +W+ ME S+ + K T+ ED + I+ I+R L
Sbjct: 84 TYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT--KGNTLKEDWIAYISREILRGL 141
Query: 178 EHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERI 236
HLH VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I
Sbjct: 142 AHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200
Query: 237 NPELNQKG-YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFS 295
+ N Y+ +SD+WS GIT IEMA P P + L + P P+L + ++S
Sbjct: 201 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDM-HPMRALFLIPRNPPPRLKSKKWS 259
Query: 296 PEFVDFTAQCLRKNPAERMSYLELMEHPF 324
+F F CL KN +R S +L++HPF
Sbjct: 260 KKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 127 bits (319), Expect = 1e-29
Identities = 92/269 (34%), Positives = 138/269 (51%), Gaps = 19/269 (7%)
Query: 67 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYT--V 124
+ +G G YG V K RH ++G + A+K + T + +E+ + L+INM +
Sbjct: 28 VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE----IKLEINMLKKYSHHRNIA 83
Query: 125 TFYGALFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRAL 177
T+YGA ++ +W+ ME S+ + K T+ ED + I+ I+R L
Sbjct: 84 TYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT--KGNTLKEDWIAYISREILRGL 141
Query: 178 EHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERI 236
HLH VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I
Sbjct: 142 AHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200
Query: 237 NPELNQKG-YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFS 295
+ N Y+ +SD+WS GIT IEMA P P + L + P P+L + ++S
Sbjct: 201 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDM-HPMRALFLIPRNPPPRLKSKKWS 259
Query: 296 PEFVDFTAQCLRKNPAERMSYLELMEHPF 324
+F F CL KN +R S +L++HPF
Sbjct: 260 KKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 127 bits (318), Expect = 2e-29
Identities = 87/281 (30%), Positives = 143/281 (50%), Gaps = 13/281 (4%)
Query: 67 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTF 126
I ELG GA+G V K ++ ++ + A K I T + +E + ++++DI + + D V
Sbjct: 37 IGELGDGAFGKVYKAQNKETSVLAAAKVID-TKSEEELEDYMVEIDI-LASCDHPNIVKL 94
Query: 127 YGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSV 186
A + E ++WI +E L++ +T E + + + AL +LH +
Sbjct: 95 LDAFYYENNLWILIEFCAGGAVDAVMLELERPLT--ESQIQVVCKQTLDALNYLHDN-KI 151
Query: 187 IHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQ-KG 244
IHRD+K N+L +G +K+ DFG+S ++ + PY MAPE + E ++ +
Sbjct: 152 IHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRP 211
Query: 245 YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQ 304
Y+ K+DVWSLGIT+IEMA + P+ LK EP R+S F DF +
Sbjct: 212 YDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKK 271
Query: 305 CLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGE 345
CL KN R + +L++HPF T+ K ++E++ E
Sbjct: 272 CLEKNVDARWTTSQLLQHPFVTVDSNKP------IRELIAE 306
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,678,653
Number of Sequences: 37866
Number of extensions: 638757
Number of successful extensions: 4565
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 568
Number of HSP's successfully gapped in prelim test: 228
Number of HSP's that attempted gapping in prelim test: 2614
Number of HSP's gapped (non-prelim): 1032
length of query: 347
length of database: 18,247,518
effective HSP length: 103
effective length of query: 244
effective length of database: 14,347,320
effective search space: 3500746080
effective search space used: 3500746080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.