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Search of human proteins with 21618347
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
(318 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 644 0.0
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 644 0.0
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi... 530 e-151
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 446 e-125
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens] 340 7e-94
gi|239751247 PREDICTED: similar to mitogen-activated protein kin... 310 1e-84
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi... 259 2e-69
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 209 2e-54
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ... 209 2e-54
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi... 205 4e-53
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [... 197 8e-51
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 165 4e-41
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 160 2e-39
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 144 1e-34
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 131 9e-31
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 131 9e-31
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 131 9e-31
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 131 9e-31
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 131 9e-31
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 131 9e-31
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 131 9e-31
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 131 9e-31
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 127 1e-29
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 127 1e-29
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 127 1e-29
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 127 1e-29
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 127 1e-29
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 127 1e-29
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 127 1e-29
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 127 2e-29
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 644 bits (1661), Expect = 0.0
Identities = 318/318 (100%), Positives = 318/318 (100%)
Query: 1 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 60
MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI
Sbjct: 1 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 60
Query: 61 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 120
MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK
Sbjct: 61 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 120
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF
Sbjct: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
Query: 181 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 240
GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE
Sbjct: 181 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 240
Query: 241 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 300
SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK
Sbjct: 241 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 300
Query: 301 TKKTDIAAFVKEILGEDS 318
TKKTDIAAFVKEILGEDS
Sbjct: 301 TKKTDIAAFVKEILGEDS 318
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 644 bits (1661), Expect = 0.0
Identities = 318/318 (100%), Positives = 318/318 (100%)
Query: 1 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 60
MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI
Sbjct: 30 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 89
Query: 61 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 120
MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK
Sbjct: 90 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 149
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF
Sbjct: 150 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 209
Query: 181 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 240
GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE
Sbjct: 210 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE 269
Query: 241 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 300
SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK
Sbjct: 270 SWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK 329
Query: 301 TKKTDIAAFVKEILGEDS 318
TKKTDIAAFVKEILGEDS
Sbjct: 330 TKKTDIAAFVKEILGEDS 347
>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
Length = 334
Score = 530 bits (1366), Expect = e-151
Identities = 258/312 (82%), Positives = 288/312 (92%)
Query: 5 PAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVK 64
P + TPPR+LDS+ I+IG++NFEV+ADDL I ELGRGAYGVVEK+RH SG IMAVK
Sbjct: 23 PQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVK 82
Query: 65 RIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRK 124
RIRATVNSQEQKRLLMDLDI+MRTVDC +TVTFYGALFREGDVWICMELMDTSLDKFY++
Sbjct: 83 RIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQ 142
Query: 125 VLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISG 184
V+DK TIPEDILG+IAVSIV+ALEHLHSKLSVIHRDVKPSNVLIN G VKMCDFGISG
Sbjct: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202
Query: 185 YLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGT 244
YLVDSVAKT+DAGCKPYMAPERINPELNQKGY+VKSD+WSLGITMIE+AILRFPY+SWGT
Sbjct: 203 YLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT 262
Query: 245 PFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKT 304
PFQQLKQVVEEPSPQLPAD+FS EFVDFT+QCL+KN ER +Y ELM+HPFFTLH++K T
Sbjct: 263 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322
Query: 305 DIAAFVKEILGE 316
D+A+FVK ILG+
Sbjct: 323 DVASFVKLILGD 334
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 446 bits (1147), Expect = e-125
Identities = 223/236 (94%), Positives = 224/236 (94%)
Query: 1 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 60
MSKPPAPNPT PRNLDSRTFITIGD NFEVEADDLVTI ELGRGAYGVVEKVRH QSGTI
Sbjct: 35 MSKPPAPNPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTI 94
Query: 61 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 120
MAVK I ATVNS EQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK
Sbjct: 95 MAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 154
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF
Sbjct: 155 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 214
Query: 181 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILR 236
GISGYLVDSVAK MDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITM +LR
Sbjct: 215 GISGYLVDSVAKMMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMGRALLLR 270
>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
Length = 399
Score = 340 bits (873), Expect = 7e-94
Identities = 171/327 (52%), Positives = 233/327 (71%), Gaps = 19/327 (5%)
Query: 7 PNPTPPRN----------LDSRTFITIG-DRNFEVEADDLVTISELGRGAYGVVEKVRHA 55
PNPT +N ++S + I +++++ A+DL + E+GRGAYG V K+ H
Sbjct: 63 PNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHK 122
Query: 56 QSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMD 115
SG IMAVKRIR+TV+ +EQK+LLMDLD+ MR+ DC Y V FYGALFREGD WICMELM
Sbjct: 123 PSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMS 182
Query: 116 TSLDKFYR---KVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKE 172
TS DKFY+ VLD IPE+ILG+I ++ V+AL HL L +IHRD+KPSN+L+++
Sbjct: 183 TSFDKFYKYVYSVLDD--VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS 240
Query: 173 GHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEM 232
G++K+CDFGISG LVDS+AKT DAGC+PYMAPERI+P +++GY+V+SDVWSLGIT+ E+
Sbjct: 241 GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL 300
Query: 233 AILRFPYESWGTPFQQLKQVVEEPSPQLPAD---RFSPEFVDFTAQCLRKNPAERMSYLE 289
A RFPY W + F QL QVV+ PQL FSP F++F CL K+ ++R Y E
Sbjct: 301 ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE 360
Query: 290 LMEHPFFTLHKTKKTDIAAFVKEILGE 316
L++HPF +++ + ++A +V +IL +
Sbjct: 361 LLKHPFILMYEERAVEVACYVCKILDQ 387
>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
kinase 3 [Homo sapiens]
Length = 198
Score = 310 bits (793), Expect = 1e-84
Identities = 150/150 (100%), Positives = 150/150 (100%)
Query: 80 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 139
MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE
Sbjct: 1 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
Query: 140 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 199
IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK
Sbjct: 61 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
Query: 200 PYMAPERINPELNQKGYNVKSDVWSLGITM 229
PYMAPERINPELNQKGYNVKSDVWSLGITM
Sbjct: 121 PYMAPERINPELNQKGYNVKSDVWSLGITM 150
>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
Length = 419
Score = 259 bits (663), Expect = 2e-69
Identities = 130/299 (43%), Positives = 202/299 (67%), Gaps = 5/299 (1%)
Query: 20 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 79
++TIG + ++ E +DL + E+G G G V K+R ++G ++AVK++R + N +E KR+L
Sbjct: 105 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL 164
Query: 80 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 139
MDLD+ +++ DC Y V +G DV+I MELM T +K +++ IPE ILG+
Sbjct: 165 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP---IPERILGK 221
Query: 140 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 199
+ V+IV+AL +L K VIHRDVKPSN+L+++ G +K+CDFGISG LVDS AKT AGC
Sbjct: 222 MTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA 281
Query: 200 PYMAPERIN-PELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSP 258
YMAPERI+ P+ + Y++++DVWSLGI+++E+A +FPY++ T F+ L +V++E P
Sbjct: 282 AYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPP 341
Query: 259 QLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGE 316
LP FS +F F CL K+ +R Y +L+EH F ++T + D+A++ K+++ +
Sbjct: 342 LLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK 400
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 209 bits (533), Expect = 2e-54
Identities = 124/338 (36%), Positives = 187/338 (55%), Gaps = 52/338 (15%)
Query: 20 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 79
F+T + E++ DD ISELG G GVV KV H SG +MA K I + + +++
Sbjct: 53 FLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII 112
Query: 80 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILG 138
+L + + + Y V FYGA + +G++ ICME MD SLD+ VL K IPE ILG
Sbjct: 113 RELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKKAGRIPEQILG 167
Query: 139 EIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGC 198
++++++++ L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G
Sbjct: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 226
Query: 199 KPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPY------------------E 240
+ YM+PER L Y+V+SD+WS+G++++EMA+ R+P +
Sbjct: 227 RSYMSPER----LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGD 282
Query: 241 SWGTP-----------------------FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCL 277
+ TP F+ L +V EP P+LP+ FS EF DF +CL
Sbjct: 283 AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCL 342
Query: 278 RKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILG 315
KNPAER +LM H F ++ D A ++ +G
Sbjct: 343 IKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380
>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
Length = 448
Score = 209 bits (533), Expect = 2e-54
Identities = 124/275 (45%), Positives = 166/275 (60%), Gaps = 20/275 (7%)
Query: 27 NFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINM 86
N ++ D+ LG G G V K H SG I+AVK I + + QK+++ +L+I +
Sbjct: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
Query: 87 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 146
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
Query: 147 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER 206
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AKT G YMAPER
Sbjct: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
Query: 207 INPELNQKGYNVKSDVWSLGITMIEMAILRFPY----ESWGT--PFQQLKQVVEEPSPQL 260
I+ E Y + SDVWSLGI+ +E+A+ RFPY ++ G+ P Q L+ +V+E SP L
Sbjct: 328 ISGE----QYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVL 383
Query: 261 PADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
P FS FV F QC+RK P ER + ELM HPF
Sbjct: 384 PVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPF 418
>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
Length = 400
Score = 205 bits (522), Expect = 4e-53
Identities = 122/341 (35%), Positives = 187/341 (54%), Gaps = 56/341 (16%)
Query: 20 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 79
F+T + E++ DD ISELG G GVV KV+H SG IMA K I + + +++
Sbjct: 57 FLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQII 116
Query: 80 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILG 138
+L + + + Y V FYGA + +G++ ICME MD SLD+ VL + IPE+ILG
Sbjct: 117 RELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKEAKRIPEEILG 171
Query: 139 EIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGC 198
+++++++R L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G
Sbjct: 172 KVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 230
Query: 199 KPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYES---------WGTP---- 245
+ YMAPER L Y+V+SD+WS+G++++E+A+ R+P +G P
Sbjct: 231 RSYMAPER----LQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDG 286
Query: 246 --------------------------------FQQLKQVVEEPSPQLPADRFSPEFVDFT 273
F+ L +V EP P+LP F+P+F +F
Sbjct: 287 EEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFV 346
Query: 274 AQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEIL 314
+CL KNPAER L H F + ++ D A ++ + L
Sbjct: 347 NKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTL 387
>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
Length = 438
Score = 197 bits (502), Expect = 8e-51
Identities = 119/271 (43%), Positives = 160/271 (59%), Gaps = 22/271 (8%)
Query: 27 NFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINM 86
N ++ D+ LG G G V K H SG I+AVK I + + QK+++ +L+I +
Sbjct: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
Query: 87 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 146
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
Query: 147 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER 206
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AKT G YMAPER
Sbjct: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
Query: 207 INPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGT--PFQQLKQVVEEPSPQLPADR 264
I+ E Y + SDVWSLGI+ +E+ ++ G+ P Q L+ +V+E SP LP
Sbjct: 328 ISGE----QYGIHSDVWSLGISFMEI------QKNQGSLMPLQLLQCIVDEDSPVLPVGE 377
Query: 265 FSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
FS FV F QC+RK P ER + ELM HPF
Sbjct: 378 FSEPFVHFITQCMRKQPKERPAPEELMGHPF 408
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 165 bits (418), Expect = 4e-41
Identities = 106/298 (35%), Positives = 164/298 (55%), Gaps = 24/298 (8%)
Query: 1 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 60
M +PPAP + + L + + F+V + +LG G+YG V K H +SG +
Sbjct: 1 MEQPPAPK-SKLKKLSEDSLTKQPEEVFDV-------LEKLGEGSYGSVFKAIHKESGQV 52
Query: 61 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLD 119
+A+K++ + QE ++ ++ I M+ D Y V +YG+ F+ D+WI ME S+
Sbjct: 53 VAIKQVPVESDLQE---IIKEISI-MQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVS 108
Query: 120 KFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCD 179
R +N T+ ED + I S ++ LE+LH + IHRD+K N+L+N EGH K+ D
Sbjct: 109 DIIRL---RNKTLIEDEIATILKSTLKGLEYLHF-MRKIHRDIKAGNILLNTEGHAKLAD 164
Query: 180 FGISGYLVDSVAKTMDA-GCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFP 238
FG++G L D++AK G +MAPE I + GYN +D+WSLGIT IEMA + P
Sbjct: 165 FGVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEIGYNCVADIWSLGITSIEMAEGKPP 220
Query: 239 YESWGTPFQQLKQVVEEPSPQL-PADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
Y P + + + P P + +S +F DF +CL KNP +R + +L++HPF
Sbjct: 221 YADI-HPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPF 277
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 160 bits (404), Expect = 2e-39
Identities = 97/261 (37%), Positives = 149/261 (57%), Gaps = 16/261 (6%)
Query: 38 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTF 97
+ +LG G+YG V K H ++G I+A+K++ + QE ++ ++ I M+ D + V +
Sbjct: 33 LEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE---IIKEISI-MQQCDSPHVVKY 88
Query: 98 YGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLS 156
YG+ F+ D+WI ME S+ R +N T+ ED + I S ++ LE+LH +
Sbjct: 89 YGSYFKNTDLWIVMEYCGAGSVSDIIRL---RNKTLTEDEIATILQSTLKGLEYLHF-MR 144
Query: 157 VIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDA-GCKPYMAPERINPELNQKG 215
IHRD+K N+L+N EGH K+ DFG++G L D++AK G +MAPE I + G
Sbjct: 145 KIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEIG 200
Query: 216 YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQL-PADRFSPEFVDFTA 274
YN +D+WSLGIT IEMA + PY P + + + P P + +S F DF
Sbjct: 201 YNCVADIWSLGITAIEMAEGKPPYADI-HPMRAIFMIPTNPPPTFRKPELWSDNFTDFVK 259
Query: 275 QCLRKNPAERMSYLELMEHPF 295
QCL K+P +R + +L++HPF
Sbjct: 260 QCLVKSPEQRATATQLLQHPF 280
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 144 bits (362), Expect = 1e-34
Identities = 96/284 (33%), Positives = 151/284 (53%), Gaps = 10/284 (3%)
Query: 38 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTF 97
+ ELG GA+G V K ++ ++G + A K I T + +E + +++++I + T D Y V
Sbjct: 39 VGELGDGAFGKVYKAKNKETGALAAAKVIE-TKSEEELEDYIVEIEI-LATCDHPYIVKL 96
Query: 98 YGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSV 157
GA + +G +WI +E LD+ +T P+ + + ++ AL LHSK +
Sbjct: 97 LGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQ--IQVVCRQMLEALNFLHSK-RI 153
Query: 158 IHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERINPE-LNQKG 215
IHRD+K NVL+ EG +++ DFG+S + ++ K PY MAPE + E +
Sbjct: 154 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 213
Query: 216 YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQ 275
Y+ K+D+WSLGIT+IEMA + P+ LK +P L ++S EF DF
Sbjct: 214 YDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKI 273
Query: 276 CLRKNPAERMSYLELMEHPF---FTLHKTKKTDIAAFVKEILGE 316
L KNP R S +L+EHPF T +K + +A E++ E
Sbjct: 274 ALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEE 317
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 131 bits (329), Expect = 9e-31
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 10 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 69
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 70 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 120
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 181 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 238
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 239 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 131 bits (329), Expect = 9e-31
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 10 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 69
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 70 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 120
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 181 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 238
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 239 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 131 bits (329), Expect = 9e-31
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 10 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 69
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 70 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 120
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 181 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 238
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 239 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 131 bits (329), Expect = 9e-31
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 10 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 69
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 70 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 120
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 181 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 238
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 239 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 131 bits (329), Expect = 9e-31
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 10 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 69
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 70 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 120
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 181 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 238
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 239 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 131 bits (329), Expect = 9e-31
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 10 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 69
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 70 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 120
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 181 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 238
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 239 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 131 bits (329), Expect = 9e-31
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 10 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 69
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 70 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 120
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 181 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 238
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 239 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 131 bits (329), Expect = 9e-31
Identities = 100/297 (33%), Positives = 149/297 (50%), Gaps = 24/297 (8%)
Query: 10 TPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT 69
+P R+LD + D E +LV G G YG V K RH ++G + A+K + T
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELV-----GNGTYGQVYKGRHVKTGQLAAIKVMDVT 59
Query: 70 VNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SLDK 120
+ +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 60 GDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTD 115
Query: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
+ K T+ E+ + I I+R L HLH VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LIKNT--KGNTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 181 GISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFP 238
G+S L +V + PY MAPE I + N Y+ KSD+WSLGIT IEMA P
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 239 YESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
P + L + P+P+L + ++S +F F CL KN ++R + +LM+HPF
Sbjct: 233 LCDMH-PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPF 288
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 127 bits (319), Expect = 1e-29
Identities = 97/307 (31%), Positives = 148/307 (48%), Gaps = 24/307 (7%)
Query: 8 NPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIR 67
+P P R+LD + D A + +G G YG V K RH ++G + A+K +
Sbjct: 3 DPAPARSLDDIDLSALRD-----PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 68 ATVNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SL 118
T + +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 58 VTEDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSV 113
Query: 119 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 178
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+
Sbjct: 114 TDLVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLV 170
Query: 179 DFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILR 236
DFG+S L +V + PY MAPE I + N Y+ +SD+WSLGIT IEMA
Sbjct: 171 DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGA 230
Query: 237 FPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF 296
P P + L + P P+L + ++S +F+DF CL K R +L++ PF
Sbjct: 231 PPLCDM-HPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
Query: 297 TLHKTKK 303
T++
Sbjct: 290 RDQPTER 296
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 127 bits (319), Expect = 1e-29
Identities = 97/307 (31%), Positives = 148/307 (48%), Gaps = 24/307 (7%)
Query: 8 NPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIR 67
+P P R+LD + D A + +G G YG V K RH ++G + A+K +
Sbjct: 3 DPAPARSLDDIDLSALRD-----PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 68 ATVNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SL 118
T + +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 58 VTEDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSV 113
Query: 119 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 178
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+
Sbjct: 114 TDLVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLV 170
Query: 179 DFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILR 236
DFG+S L +V + PY MAPE I + N Y+ +SD+WSLGIT IEMA
Sbjct: 171 DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGA 230
Query: 237 FPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF 296
P P + L + P P+L + ++S +F+DF CL K R +L++ PF
Sbjct: 231 PPLCDM-HPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
Query: 297 TLHKTKK 303
T++
Sbjct: 290 RDQPTER 296
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 127 bits (319), Expect = 1e-29
Identities = 97/307 (31%), Positives = 148/307 (48%), Gaps = 24/307 (7%)
Query: 8 NPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIR 67
+P P R+LD + D A + +G G YG V K RH ++G + A+K +
Sbjct: 3 DPAPARSLDDIDLSALRD-----PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 68 ATVNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SL 118
T + +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 58 VTEDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSV 113
Query: 119 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 178
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+
Sbjct: 114 TDLVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLV 170
Query: 179 DFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILR 236
DFG+S L +V + PY MAPE I + N Y+ +SD+WSLGIT IEMA
Sbjct: 171 DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGA 230
Query: 237 FPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF 296
P P + L + P P+L + ++S +F+DF CL K R +L++ PF
Sbjct: 231 PPLCDM-HPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
Query: 297 TLHKTKK 303
T++
Sbjct: 290 RDQPTER 296
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 127 bits (319), Expect = 1e-29
Identities = 97/307 (31%), Positives = 148/307 (48%), Gaps = 24/307 (7%)
Query: 8 NPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIR 67
+P P R+LD + D A + +G G YG V K RH ++G + A+K +
Sbjct: 3 DPAPARSLDDIDLSALRD-----PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 68 ATVNSQEQKRLLMDLDINMRTVDCFYT--VTFYGALFREG------DVWICMELMDT-SL 118
T + +E+ + +INM + T+YGA ++ +W+ ME S+
Sbjct: 58 VTEDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSV 113
Query: 119 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 178
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+
Sbjct: 114 TDLVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLV 170
Query: 179 DFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGITMIEMAILR 236
DFG+S L +V + PY MAPE I + N Y+ +SD+WSLGIT IEMA
Sbjct: 171 DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGA 230
Query: 237 FPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF 296
P P + L + P P+L + ++S +F+DF CL K R +L++ PF
Sbjct: 231 PPLCDM-HPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
Query: 297 TLHKTKK 303
T++
Sbjct: 290 RDQPTER 296
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 127 bits (319), Expect = 1e-29
Identities = 92/269 (34%), Positives = 138/269 (51%), Gaps = 19/269 (7%)
Query: 38 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYT--V 95
+ +G G YG V K RH ++G + A+K + T + +E+ + L+INM +
Sbjct: 28 VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE----IKLEINMLKKYSHHRNIA 83
Query: 96 TFYGALFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRAL 148
T+YGA ++ +W+ ME S+ + K T+ ED + I+ I+R L
Sbjct: 84 TYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT--KGNTLKEDWIAYISREILRGL 141
Query: 149 EHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERI 207
HLH VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I
Sbjct: 142 AHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200
Query: 208 NPELNQKG-YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFS 266
+ N Y+ +SD+WS GIT IEMA P P + L + P P+L + ++S
Sbjct: 201 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDM-HPMRALFLIPRNPPPRLKSKKWS 259
Query: 267 PEFVDFTAQCLRKNPAERMSYLELMEHPF 295
+F F CL KN +R S +L++HPF
Sbjct: 260 KKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 127 bits (319), Expect = 1e-29
Identities = 92/269 (34%), Positives = 138/269 (51%), Gaps = 19/269 (7%)
Query: 38 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYT--V 95
+ +G G YG V K RH ++G + A+K + T + +E+ + L+INM +
Sbjct: 28 VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE----IKLEINMLKKYSHHRNIA 83
Query: 96 TFYGALFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRAL 148
T+YGA ++ +W+ ME S+ + K T+ ED + I+ I+R L
Sbjct: 84 TYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT--KGNTLKEDWIAYISREILRGL 141
Query: 149 EHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERI 207
HLH VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I
Sbjct: 142 AHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200
Query: 208 NPELNQKG-YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFS 266
+ N Y+ +SD+WS GIT IEMA P P + L + P P+L + ++S
Sbjct: 201 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDM-HPMRALFLIPRNPPPRLKSKKWS 259
Query: 267 PEFVDFTAQCLRKNPAERMSYLELMEHPF 295
+F F CL KN +R S +L++HPF
Sbjct: 260 KKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 127 bits (319), Expect = 1e-29
Identities = 92/269 (34%), Positives = 138/269 (51%), Gaps = 19/269 (7%)
Query: 38 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYT--V 95
+ +G G YG V K RH ++G + A+K + T + +E+ + L+INM +
Sbjct: 28 VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE----IKLEINMLKKYSHHRNIA 83
Query: 96 TFYGALFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRAL 148
T+YGA ++ +W+ ME S+ + K T+ ED + I+ I+R L
Sbjct: 84 TYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT--KGNTLKEDWIAYISREILRGL 141
Query: 149 EHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERI 207
HLH VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I
Sbjct: 142 AHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200
Query: 208 NPELNQKG-YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFS 266
+ N Y+ +SD+WS GIT IEMA P P + L + P P+L + ++S
Sbjct: 201 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDM-HPMRALFLIPRNPPPRLKSKKWS 259
Query: 267 PEFVDFTAQCLRKNPAERMSYLELMEHPF 295
+F F CL KN +R S +L++HPF
Sbjct: 260 KKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 127 bits (318), Expect = 2e-29
Identities = 87/281 (30%), Positives = 143/281 (50%), Gaps = 13/281 (4%)
Query: 38 ISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTF 97
I ELG GA+G V K ++ ++ + A K I T + +E + ++++DI + + D V
Sbjct: 37 IGELGDGAFGKVYKAQNKETSVLAAAKVID-TKSEEELEDYMVEIDI-LASCDHPNIVKL 94
Query: 98 YGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSV 157
A + E ++WI +E L++ +T E + + + AL +LH +
Sbjct: 95 LDAFYYENNLWILIEFCAGGAVDAVMLELERPLT--ESQIQVVCKQTLDALNYLHDN-KI 151
Query: 158 IHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERINPELNQ-KG 215
IHRD+K N+L +G +K+ DFG+S ++ + PY MAPE + E ++ +
Sbjct: 152 IHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRP 211
Query: 216 YNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQ 275
Y+ K+DVWSLGIT+IEMA + P+ LK EP R+S F DF +
Sbjct: 212 YDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKK 271
Query: 276 CLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGE 316
CL KN R + +L++HPF T+ K ++E++ E
Sbjct: 272 CLEKNVDARWTTSQLLQHPFVTVDSNKP------IRELIAE 306
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,278,571
Number of Sequences: 37866
Number of extensions: 535760
Number of successful extensions: 3656
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 564
Number of HSP's successfully gapped in prelim test: 221
Number of HSP's that attempted gapping in prelim test: 1753
Number of HSP's gapped (non-prelim): 978
length of query: 318
length of database: 18,247,518
effective HSP length: 102
effective length of query: 216
effective length of database: 14,385,186
effective search space: 3107200176
effective search space used: 3107200176
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.